VictorJuiz/thesis huggingface dataset:
The archaeology of Greek warriors and warfare from the eleventh to the early seventh century BCE
Keywords: warriors
Greece
Early Iron Age
warfare
war

This thesis studies the evidence related to warfare and warriors in the Early Iron Age of Greece, from the eleventh to the early seventh century B.C.E. It argues that "warrior" identity, as expressed through burial with weapons or depictions of armed men and combat in pictorial painting and literature, is connected to violent action in order to create, maintain, and reinforce the relationship between authority and violent action. The forms that this violent action took were variable, from interregional conflict to overseas raids. This is outlined in Chapter 1, which is followed by two chapters summarizing the palatial (Chapter 2) and postpalatial (Chapter 3) background to the Early Iron Age.
Chapters 4 to 7 present the evidence. In order to provide a more thorough analysis the focus is limited to the regions of Attica, central Euboea, the Argolid, and Knossos. The study of warfare in this period has been dominated by the study of weapons; in this thesis the approach focuses on the contexts in which these weapons are found, burials (Chapter 4), sanctuaries (Chapter 5), and occasionally settlements (Chapter 6). In these chapters the particular treatment and emphasis on weapons and armour is considered based on an understanding of these contexts in the period. In Chapter 7, representations and the treatment of warriors and warfare in Early Iron Age pictorial pottery is considered, as is briefly the literary evidence from the end of this period, which form the means by which contemporary people came to understand warfare. Chapter 8 discusses the evidence, while Chapter 9 summarizes the conclusions.
This thesis shows that while warrior identity and the practice of war are closely related, in these areas of Early Iron Age Greece there are variations in the identification of men as warriors and in the intensity with which war is fought. Throughout the period, these regions express warrior identity in broadly similar ways, but with variations in duration, accessibility, and meaning. The eighth century is particularly a period of change with the intensification of warfare manifest in the destruction of settlements, but these changes are not restricted to this century, and are in many ways similar to the preceding centuries on a larger scale.
Mathematical modelling of metabolism and acidity in cancer
Keywords: systems biology
partial differential equations
Bayesian methods
acid-mediated tumour invasion
cellular metabolism
asymptotic analysis
cancer
global sensitivity analysis

Human cancers exhibit the common phenotype of elevated glycolytic metabolism, which causes acidification of the tissue microenvironment and may facilitate tumour invasion. In this thesis, we use mathematical models to address a series of open problems underlying the glycolytic tumour phenotype and its attendant acidity.
We first explore tissue-scale consequences of metabolically-derived acid. Incorporating more biological detail into a canonical model of acidity at the tumour-host interface, we extend the range of tumour behaviours captured by the modelling framework. We then carry out an asymptotic travelling wave analysis to express invasive tumour properties in terms of fundamental parameters, and find that interstitial gaps between an advancing tumour and retreating healthy tissue, characteristic of aggressive invasion and comprising a controversial feature of the original model, are less significant under our generalised formulation.
Subsequently, we evaluate a potential role of lactate---historically assumed to be a passive byproduct of glycolytic metabolism---in a perfusion-dependent metabolic symbiosis that was recently proposed as a beneficial tumour behaviour. Upon developing a minimal model of dual glucose-lactate consumption in vivo and employing a multidimensional sensitivity analysis, we find that symbiosis may not be straightforwardly beneficial for our model tumour. Moreover, new in vitro experiments, carried out by an experimental collaborator, place U87 glioblastoma tumours in a weakly symbiotic parameter regime despite their clinical malignancy. These results suggest that intratumoural metabolic cooperation is unlikely to be an important role for lactate.
Finally, we examine the complex pH regulation system that governs expulsion of metabolically derived acid loads across tumour cell membranes. This system differs from the healthy system by expression of only a few key proteins, yet its dynamics are non-intuitive in the crowded and poorly perfused in vivo environment. We systematically develop a model of tumour pH regulation, beginning with a single-cell scenario and progressing to a spheroid, within a Bayesian framework that incorporates information from in vitro data contributed by a second experimental collaborator. We predict that a net effect of pH regulation is a straightforward transmembrane pH gradient, but also that existing treatments are unable to disrupt the system strongly enough to cause tumour cell death.
Taken together, our models help to elucidate previously unresolved features of glycolytic tumour metabolism, and illustrate the utility of a combined mathematical, statistical, and experimental approach for testing biological hypotheses. Opportunities for further investigation are discussed.
Combining regulatory angiogenic gene therapy and virotherapy for the treatment of breast cancer
Keywords: cancer
breast cancer
angionenesis
oncolytic virus
gene therapy

This thesis describes the design of a virotherapy strategy capable of destroying both breast cancer vasculature and tumour cells, using an oncolytic adenovirus expressing angiogenesis-regulating proteins. Five oncolytic adenoviruses were compared to identify the best virotherapy agent for breast cancer, including measurement of cytotoxicity in vitro, and replication, intra-tumoural spread and anticancer efficacy in vivo. The viruses tested were Ad-dl922-947 (targets G1-S checkpoint defects); Ad-Onyx-015 and Ad-Onyx-017 (target p53/mRNA nuclear export defects); Ad-vKH1 (targets Wnt pathway defects) and AdEHE2F (targets estrogen receptor/G1-S checkpoint/hypoxia signalling defects).
AdEHE2F demonstrated optimal oncolytic activity and selectivity against breast cancer, accordingly this virus was engineered to express potent regulatory angiogenic proteins, namely soluble Flt1 and soluble Delta like-4 (Dll4). sFlt1 is the soluble extra-cellular domain of VEGFR1 and binds to and sequesters VEGF-A, thereby preventing VEGFR2 stimulation which is crucial to trigger angiogenesis. sDll4 is the soluble extracellular domain of Dll4 and has been previously shown to block Dll4/Notch signalling. Dll4/Notch signalling increases a chaotic and non-functional angiogenesis which ultimately delays tumour growth. Importantly, VEGF and Dll4 are the only angiogenesis genes reported to be haploinsufficient in vascular development and both have been shown to have a good anti-tumour effect.
sFlt1 and sDll4 genes were substituted for the viral genes E3 6.7K/gp19K of AdEHE2F, thereby using endogenous adenoviral machinery to drive production. The activities of AdEHE2F viruses expressing either sFlt1 or sDll4 were compared in vitro and in vivo. sFlt1 (expressed from AdEHE2F) inhibited endothelial cell proliferation and sprouting whereas sDll4 increased proliferation and branching in vitro. In vivo AdEHE2F expressing sFlt1 or sDll4 both showed superior anticancer activity compared to parental AdEHE2F, indicating at least additive efficacy between virotherapy and regulatory angiogenic approaches.
Local gradient estimate for porous medium and fast diffusion equations by Martingale method
Keywords: Aronson-Benilan estimate
Porous medium equation
Martingale
Curvature-dimension condition
Fast diffusion equation

This thesis focuses on a certain type of nonlinear parabolic partial differential equations, i.e. PME and FDE, which can be written as ∂tu = Δum with m > 0. Our aim is to derive better gradient bound in the form of
|∇u|2 (t,·) ≤ C   ||u(0,·)||k∞ − uk (t,·)
t ,  and   |∇u|2
uk1 ,  (t,·) −   ∂tu
uk2 ,  (t,·) ≤   C1
t ·
Chapter 1 consists of a survey on results related to PME and FDE, and a short review on some works about deriving gradient estimates in probabilistic ways.
In Chapter 2 we estimate gradient on space variables of solutions to the heat equation on Euclidean space. The main idea is to construct two semimartingales by letting the solution and its gradient running backward on the path space of a diffusion process. Estimates derived from decompositions of those two semimartingales are then combined to give rise to an upper bound on gradient that only involves the maximum of the initial data and time variable. In particular, it is independent of the dimension.
In Chapter 3 we carry the idea in Chapter 2 onto the study of positive solutions to PME or FDE, and obtained a similar type of bound on |∇u| for local solutions to PME or FDE on Euclidean space. In existing literature there have always been constraints on m. By considering a more general form of transformation on u and introducing a family of equivalent measures on path space, we add more flexibility to our method. Thus our result is valid for a larger range of m. For global solutions, when m violates our constraint, we need two-sided bound on u to control |∇u|.
In Chapter 4 we utilize maximum principle to derive Li-Yau type gradient estimate for PME on a compact Riemannian manifold with Ricci curvature bounded from below. Our result is able to yield a Harnack inequality possessing the right order in time variable when the lower bound of Ricci curvature is negative.
The God of possibility and promise: Christian eschatology as a response to technological futurism
Keywords: Religion and Culture
Philosophy of Religion
Christian Eschatology
Technology

The explosive growth of technology today is causing extensive speculation about the future. These ‘technological futurisms’—especially transhumanism—are often imbued with religious value by their adherents. How should Christians respond to the content of technological futurisms and also the way the future is constructed? In this thesis I argue that Christian eschatology has a more robust understanding of the future than technological futurism, as championed by transhumanism, and can allow for radical hope while also maintaining important humanistic virtues which are ultimately lost in transhumanism. Christian eschatology does not only depend on what is actual to create its future. Rather, it is open to the God of possibility and promise who can bring the radically new in the Kingdom of God.
This dissertation is broken into three major sections with an introductory and concluding chapter. The first section provides a history of our technological imagination today by looking at visionary approaches to technology and the future in both technological utopias and science fiction. This history provides the conditions for understanding the proposed future of transhumanism. The second section orients the final response by assessing technology and the future in the eschatologies of Pierre Teilhard de Chardin and Jacques Ellul. Both Teilhard and Ellul agree that the technological future without appeal to the Christian God is dangerous. The final section looks at the theological and philosophical issues surrounding technology and the future. Heidegger’s works are used to sharpen themes related to technology and the future; in particular, how technology is related to ontology and how the future is related to possibility. The final chapters construct a Christian response to transhumanism around the themes of possibility and promise by utilising the works of Richard Kearney, Eberhard Jüngel and Jürgen Moltmann. A Christian notion of possibility allows for the radically new in a way transhumanism does not and the Christian idea of promise safeguards human virtues by emphasising the interpersonal as ultimate rather than self-transcendence as with transhumanism.
Surface active polymers as anti-infective and anti-biofouling materials
Keywords: organic chemical coatings
surface chemistry control
antibacterial surfaces

This thesis is concerned with the chemical modification of polymers in the preparation of a library of materials which exhibit altered surface properties as a result of the surface chemical functionality, with particular emphasis on the development of materials that control biofouling and are antibacterial. Chemical modification of crosslinked polystyrene, in film and microsphere form, was carried out by carbene insertion followed by diazonium coupling. This provided access to a collection of materials with varying surface chemistry, whilst the bulk properties of the polystyrene substrates were maintained. Synthesis of the diaryldiazo and the diazonium salts used to perform the surface modifications is described, as well as the preparation and characterisation of the materials.
Analysis of the ability of the materials to adsorb and bind the protein bovine serum albumin (BSA) is presented with data obtained from two methods of observation. Quartz Crystal Microbalance with Dissipation (QCM-D) and a protein assay based on the change in optical density of a BSA/PBS solution are used to demonstrate how the specific surface chemistry of the materials influences the ability to adsorb and bind protein. The behaviour of the materials was time dependent and was rationalised with respect to the surface water contact angle and the calculated parameters polar surface area and % polar surface area of the functional groups added to the surfaces.
Finally, penicillin loaded materials were prepared and their antibacterial activity was tested against E. coli and S. aureus, demonstrating that the antibiotic is still active from within the polystyrene scaffold.
Exploring the roles of LIM domain binding proteins in zebrafish development
Keywords: Zebrafish
Development
Ldb
LIM domain
TGFb
Auto-regulatory feedback loops

As some of the most important and widely utilised intercellular signalling molecules, transforming growth factor βs (TGFβs) play critical roles in normal development and in human disease. Establishing appropriate levels of signalling involves positive and negative feedback, driven by the same signal transduction components, but whether or how the two are distinguished has not previously been understood. Here we show that LIM domain binding proteins (Ldbs) drive the Smad6/7-mediated negative feedback of TGFβ signalling, but they are not required for the ligand-driven positive feedback or other downstream transcriptional activation. In Ldb-deficient zebrafish embryos, the homeostasis of TGFβ signalling is perturbed. As a consequence, signalling of TGFβ family members, Nodal and BMP, is stably enhanced, giving rise to excess mesoderm and endoderm, an effect that can be rescued by reducing Nodal and BMP. Later in development, conditional ldb2a knockdown causes defective vascular, angiogenic and haemogenic development, likely also by elevating TGFβ signalling. Thus, Ldbs control the homeostatic regulation of TGFβ signalling and therefore play critical roles in diverse developmental processes.
Factorisation in relational databases
Keywords: Factorisation
Query Processing
Algorithms
Relational Databases

We study representation systems for relational data based on relational algebra expressions with unions, products, and singleton relations. Algebraic factorisation using the distributivity of product over union allows succinct representation of many-to-many relationships; further succinctness is brought by sharing repeated subexpressions. We show that these techniques are especially applicable to results of conjunctive queries.
In the first part of the dissertation we derive tight asymptotic size bounds for two flavours of factorised representations of results of conjunctive queries. Any conjunctive query is characterised by rational parameters that govern the factorisability of its results independently of the database instance. We relate these parameters to fractional edge covers and fractional hypertree decompositions.
Factorisation naturally extends from relational data to its provenance. We characterise conjunctive queries by tight bounds on their readability, which captures how many times each input tuple is used to contribute to an output tuple, and we define syntactically the class of queries with bounded readability.
In the second part of the dissertation we describe FDB, a relational database engine that uses factorised representations at the physical layer to reduce data redundancy and boost query performance. We develop algorithms for optimisation and evaluation of queries with selection, projection, join, aggregation and order-by clauses on factorised representations. By introducing novel operators for factorisation restructuring and a new optimisation objective to maintain intermediate and final results succinctly factorised, we allow query evaluation with lower time complexity than on flat relations. Experiments show that for data sets with many-to-many relationships, FDB can outperform relational engines by orders of magnitude.
Derived symplectic structures in generalized Donaldson–Thomas theory and categorification
Keywords: derived algebraic geometry
Donaldson-Thomas invariants

This thesis presents a series of results obtained in [13, 18, 19, 23{25, 87]. In [19], we prove a Darboux theorem for derived schemes with symplectic forms of degree k < 0, in the sense of [142]. We use this to show that the classical scheme X = t0(X) has the structure of an algebraic d-critical locus, in the sense of Joyce [87]. Then, if (X, s) is an oriented d-critical locus, we prove in [18] that there is a natural perverse sheaf P•X,s on X, and in [25], we construct a natural motive MFX,s, in a certain quotient ring MμX of the μ-equivariant motivic Grothendieck ring MμX, and used in Kontsevich and Soibelman's theory of motivic Donaldson-Thomas invariants [102]. In [13], we obtain similar results for k-shifted symplectic derived Artin stacks.
We apply this theory to categorifying Donaldson-Thomas invariants of Calabi-Yau 3-folds, and to categorifying Lagrangian intersections in a complex symplectic manifold using perverse sheaves, and to prove the existence of natural motives on moduli schemes of coherent sheaves on a Calabi-Yau 3-fold equipped with 'orientation data', as required in Kontsevich and Soibelman's motivic Donaldson-Thomas theory [102], and on intersections L∩M of oriented Lagrangians L,M in an algebraic symplectic manifold (S,ω). In [23] we show that if (S,ω) is a complex symplectic manifold, and L,M are complex Lagrangians in S, then the intersection X= L∩M, as a complex analytic subspace of S, extends naturally to a complex analytic d-critical locus (X, s) in the sense of Joyce [87]. If the canonical bundles KL,KM have square roots K1/2L, K1/2M then (X, s) is oriented, and we provide a direct construction of a perverse sheaf P•L,M on X, which coincides with the one constructed in [18].
In [24] we have a more in depth investigation in generalized Donaldson-Thomas invariants DTα(τ) defined by Joyce and Song [85]. We propose a new algebraic method to extend the theory to algebraically closed fields K of characteristic zero, rather than K = C, and we conjecture the extension of generalized Donaldson-Thomas theory to compactly supported coherent sheaves on noncompact quasi-projective Calabi-Yau 3-folds, and to complexes of coherent sheaves on Calabi-Yau 3-folds.
Climate change adaptation and tourism in the Mexican Caribbean
Keywords: tourism
adaptation to climate change
climate change policy
Latin America
Mexican Caribbean
climate change
Mexico

The Mexican Caribbean tourism sector is highly exposed to hurricane activity, yet coastal tourism is also a major driver influencing regional biophysical and social vulnerability to climate risks. Drawing on a political ecology approach and a vulnerability assessment, this study asks how experiences with extreme hurricane events in the Mexican Caribbean shape climate change adaptation in the regional tourism sector. This study uses multiple methods, scales and field sites to (a) examine how biophysical vulnerability to extreme hurricanes affects the tourism sector, (b) explain the changing conditions of social vulnerability linked to hurricane damage in the tourism sector and (c) assess the present and future opportunities and obstacles for adaptation planning.
The main findings show that the region is experiencing a phase of unprecedented high intensity hurricanes. It is uncertain, however, whether changes in hurricane activity exceed natural multi-decadal variability. Tourism is one major driver of land use changes which have resulted in some of the world’s fastest increase in coastal urban sprawl. Most tourism infrastructure is located in areas with the greatest exposure to hurricanes. Hurricane Wilma which hit the region in 2005 is the most expensive natural disaster in the history of the Mexican insurance industry. Hotels have showed a high ability to recover operations after hurricanes. There is a high penetration of insurance ownership in hotels and there is substantial mobilization of public and private financial and human resources during hurricane disasters. Hotel responses to hurricanes, however, tend to be reactive and autonomous. One important consequence of hurricanes is that hoteliers in the interest to reduce operational costs, fire those workers with the weakest labour rights. Thus, hotel workers suffer from ‘double exposure’, a situation where hotel workers are confronted with the consequences of climate change while simultaneously suffering the consequences of globalization and neoliberal policies which have reduced the power of unions and weakened access to social security. The Mexican government has created a national climate change strategy and its operational programme which has led to the consolidation of an adaptation organizational structures at the national and state levels. I conclude, however, that adaptation planning may not result in the necessary actions on the ground since local actors are not well integrated yet into such efforts.
This study shows the importance of regional adaptation research that takes into account perspectives from both the physical and social sciences. This study highlights the importance of interactions between local actors, the larger socioeconomic and political economy context to inform adaptation planning and policy.