VictorJuiz/thesis huggingface dataset:
Essays on two-sector matching, status rewards and liability
Keywords: Social Status
Matching
Occupational Sorting

This thesis consists of three self-contained chapters.
Chapter 1 develops a two-sector, bivariate matching model, in which each sector uses a different dimension of skill in the production process. I show there exists a unique assignment of agents to sectors and derive comparative statics. The main result is that if jobs are scarce, both an increase in sector one skills' spread and a technological improvement increase the supply of talent in sector one, but decrease it in sector two. In sector two, this raises wages and wage inequality. In sector one, the effects are ambiguous in general, but wages increase for the most and decrease for the least talented agents.
Chapter 2 studies the impact of social status on occupational sorting in a two-sector matching framework. Talent is two-dimensional and thus status is not a zero-sum game; it depends both on occupational prestige and within-sector rank (local status). I show that the weights with which these two components enter -- the structure of status -- crucially influence the way in which agents self-select into sectors and argue that it is likely that these weights differ across occupations. The more important are the individual components of status in a sector, or the less important the collective component, the better the agents who join that industry, which has important implications for total payoffs, wage levels and inequality, and profits. I also show that the stable assignment is typically inefficient, which is driven by the distortion of relative status rewards, not status concerns per se.
Chapter 3 investigates whether directors of companies should have limited liability. I develop a three-player model in which: (a) debtholders and equityholders are defined by their control rights and (b) the project is run by the directors. The main result is that increased liability for directors forces them to internalise more of the downside risk of the project and hence reduces their risk-taking. This is optimal if over-investment was a problem initially. I show that the extent to which over-investment is a problem depends on how well debtholders are protected compared to equityholders. If debtholders are strong, increased liability can cause under-investment.
The role of alpha-synuclein oligomers in Parkinson's disease pathophysiology and biology
Keywords: Parkinson's disease
Pathology
Alpha-synuclein
Drug screen
Oligomers

Accumulating evidence links oligomeric species of the protein alpha-synuclein to the neuronal death associated with Parkinson's disease. However, the direct detection of alpha-synuclein oligomers in post-mortem brain has been challenging and this has limited our understanding of their structure, distribution and effects in Parkinson's disease.
The work presented in this thesis addresses two aspects of the role of alpha-synuclein oligomers in Parkinson's disease. Firstly, I describe the development of a novel technique, the alpha-synuclein proximity ligation assay (AS-PLA), which specifically detected alpha-synuclein oligomers in vitro and in post-mortem brain tissue. In a blinded study with post-mortem brain tissue from eight Parkinson's disease patients and eight controls, AS-PLA revealed widespread, previously unrecognised pathology in the form of extensive diffuse deposition of alpha-synuclein oligomers. Furthermore, AS-PLA preferentially detected early-stage, loosely compacted Parkinson's disease lesions such as pale bodies, whereas Lewy bodies, considered heavily compacted late lesions were only very exceptionally stained. The oligomeric species detected by AS-PLA displayed a unique, intermediate proteinase K resistance profile, suggesting the detection of a conformer that is different from both physiological pre-synaptic alpha-synuclein (proteinase K sensitive) and highly aggregated alpha-synuclein within Lewy bodies (proteinase K resistant). In addition, AS-PLA revealed the age-dependent accumulation of alpha-synuclein oligomers in the substantia nigra of a BAC transgenic mouse model of Parkinson's disease that overexpresses human wild-type alpha-synuclein, SNCA-OVX.
Secondly, the detection of early pathology in Parkinson's disease brain tissue using AS-PLA suggests that oligomeric species of alpha-synuclein could represent a potential target for therapeutic intervention. Therefore, I undertook a screen to identify compounds that can prevent the formation of alpha-synuclein oligomers in vitro. Using bimolecular fluorescence complementation constructs, I identified nine compounds capable of reducing the fluorescence indicative of the formation of alpha-synuclein oligomers. Two of these compounds showed dose-dependent activity. Future work will confirm the hits in vitro before studying whether Parkinson's-like phenotypes in the SNCA-OVX mice can be ameliorated or reversed by treatment with the compounds.
Early microlithic technologies and behavioural variability in southern Africa and South Asia
Keywords: Microlith
Howiesons Poort
Palaeolithic
Lithic technology

Microlith production is a distinctive and significant stone tool technology. However, inter-regional comparative analyses of microlithic industries are rare, and have tended to homogenise these industries by focussing analytical attention on retouched tool typologies alone. This thesis provides the first demonstration and exploration of variability in two of the earliest microlithic industries in the world – the Howiesons Poort of southern Africa and the Late Palaeolithic of South Asia. Analysis of this variation has implications for the long-standing debates concerning modern human behaviour and dispersals.
In order to assess variability in underlying technological processes and manufacturing trajectories, detailed attribute analyses were conducted on lithic assemblages. Metric and qualitative variables were recorded on cores, debitage and tools from three southern African Howiesons Poort sites (Rose Cottage Cave and Umhlatuzana, South Africa, and Ntloana Tsoana, Lesotho) and four South Asian Late Palaeolithic sites (Batadomba-lena and Kitulgala Beli-lena, Sri Lanka, and Patne and Jwalapuram 9, India).
Analysis of the results reveals variability within sites, over time, and between sites and regions, demonstrating that microlith production is not a homogenous technology. Underlying technological processes are shown to differ more between regions than do retouched tool forms. It is argued that this pattern is more parsimoniously explained by independent innovation of microlithic technology situated within local lithic traditions, rather than by cultural diffusion. Additionally, the exploration of variability in microlithic assemblages highlights the benefits of using a methodological approach to the modern human behaviour debate which focusses on technological variability rather than the presence of particular tool types. It is this behavioural and technological variability that is key to understanding our species.
Making ladies of girls : middle-class women and pleasure in urban India
Keywords: young women
India
ethnographic study
femininity
tradition
globalisation
middle class

Current debates in the anthropology of the Indian middle classes suggest a preponderant theme of balance – between 'Indian' and 'Western'; 'traditional’ and ‘modern'; 'global' and 'local'. Scholars like Säävälä (2010) Nisbett (2007, 2009), and Donner (2011) demonstrate a range of practices through which the ideal of middle class life is positioned in a precarious median between the imagined decadence of the upper classes and the perceived immorality and lack of responsibility of the working classes. Sexuality and intimacy, it has been observed, are important sites, where this balancing act is played out and risks to its stability are disciplined. Young women have particularly come under a great deal of pressure to position themselves dually as modern representatives of a global nation, who are, at the same time, epitomes of a nationalised narrative of tradition. In this thesis I examine, through an ethnographic study, the ways in which young women’s bodies are implicated in the normative reproduction of everyday middle class life, as well as unpacking the social meanings of youth and adulthood for women in this context. Further, locating my study in the context of women’s colleges in Chennai, this thesis comments on the significance of educational spaces as sites where normative ideals of middle class life and femininity are both produced and contested. The chief arguments in this thesis are organised into five chapters that draw primarily on ethnographic material to examine categories of risk, danger and pleasure as mutually constituted in young women’s lives through everyday practice, as well as the making of the everyday as a precarious and compositional event.
Imperial infrastructure and spatial resistance in colonial literature (1880-1930)
Keywords: Colonialism
British Empire
South Africa
Colonial Literature
Imperialism
Resistance
Infrastructure
India

Between 1880 and 1930, the British Empire’s vast infrastructural developments facilitated the incorporation of large parts of the globe into what Immanuel Wallerstein and others have called the capitalist 'world-system'. Colonial literature written throughout this period, in recording this vast expansion, repeatedly cites imperial infrastructures to make sense of the various geographies in which it is set. Physical embodiments of empire proliferate in this writing. Railways and trains, telegraph wires and telegrams, roads and bridges, steamships and shipping lines, canals and other forms of irrigation, cantonments, the colonial bungalow and other kinds of colonial urban architecture—all of these infrastructural lines break up the landscape and give shape to the literature’s depiction and production of colonial space.
In order to analyse these physical embodiments of empire in colonial literature, this thesis develops a methodological reading practice called infrastructural reading. Rooted in a dualistic, yet connected use of the word 'infrastructure', this reading strategy works as a critical tool for analysing a mutually sustaining relationship embedded within these literary narratives. It focuses on the infrastructures in the text, both physical and symbolic, in order to excavate the infrastructures of the text, be they geographic, social or economic—namely, the material conditions of the world-system that underpinned Britain's imperial expansion. This methodology is applied to a number of colonial authors including H. Rider Haggard, Olive Schreiner, William Plomer and John Buchan in South Africa and Flora Annie Steel, E.M. Forster, Edmund Candler and Edward Thompson in India. The results show that the infrastructural networks that circulate through colonial fiction are almost always related to some form of anti-imperial resistance, manifestations that include ideological anxieties, limitations and silences, as well as more direct objections to and acts of violent defiance against imperial control and capitalist accumulation. In so doing, the thesis demonstrates how this literary-cultural terrain and the resistance embedded within it has been shaped by, and has in turn shaped, the infrastructure of the capitalist world-system.
Vowed to community or ordained to mission? Aspects of separation and integration in the Lutheran Deaconess Institute Neuendettelsau, Bavaria
Keywords: Collective identity
nineteenth-century deaconess movement
construction of femininity and masculinity
nineteenth-century Lutheran neo-confessionalism
cultural formation
religious identities
historical-theological gender research

This study offers an overdue exploration of the early years of the deaconess community in Neuendettelsau from a gender perspective. Drawing on rich archival material, it focuses on the process of the formation of a distinctive collective identity. Central to this study is the assumption, drawn from the social sciences, that collective identity is a social construction which requires the participation of the whole group through identification and which is consolidated by developing specific rituals, symbols, codes and normative texts, which facilitate integration, and by constructing external boundaries, which separate from the world and wider church. The centrifugal forces which came into play when deaconesses were sent out in isolation were counterbalanced by a communal life which offered forms of participation and identification for the individual members and which consolidated their sense of belonging.
The first chapter introduces the methodology. Chapter Two explores the social, cultural and theological context of the foundation of the Deaconess Institute, and offers a brief outline of the institution's historical development. The third chapter offers an in-depth analysis of the initiation ceremony as a rite which both admitted into the community and conferred an ecclesiastical office. Chapter Four analyses formative and normative texts that shed light on the community's norms, values, and expectations. In the fifth chapter, non-literary means of consolidating and affirming the deaconesses' collective identity are explored. This study concludes that the process of the emergence of a specific deaconess culture was pervaded by bourgeois norms, values, patterns of behaviour and notions about gender roles which measured out the women's radius of action and were at times difficult to reconcile with the deaconess profession.
Mononuclear phagocytes in intestinal homeostasis and inflammation
Keywords: Colitis
Intestinal Immunology
Inflammatory Bowel Disease
Intestinal Inflammation
Mononuclear Phagocytes
Immunology
Macrophages
Monocytes
Interleukin-23 (IL-23)

Changes to the composition and function of the gut mononuclear phagocyte (MNP) compartment are associated with the development of intestinal inflammation. Much work has focused on the role of MNPs in gut-associated lymphoid tissue in maintaining homeostasis, however little is known regarding the roles of MNPs during colitis. We have investigated MNPs in the large intestinal lamina propria during the steady state and inflammation. One of our primary aims was to determine the contribution of MNP subsets to intestinal pathology. For our studies of inflammation, we focused mainly on the Helicobacter hepaticus infection &plus; anti-IL-10R model, which induces inflammation of the colon and caecum (typhlocolitis). We defined the composition of the MNP compartment alongside intestinal pathology scores throughout Hh &plus; anti-IL-10R typhlocolitis. Peak pathology, 2-3 weeks after induction of colitis, coincided with peak frequencies of CX3CR1int Ly6C&plus; MNPs. Having observed the accumulation of CX3CR1int CD64&plus; monocyte/macrophage MNPs in the inflamed lamina propria, we conducted comparative whole genome microarray analysis of these cells isolated from the large intestine three weeks after Hh &plus; anti-IL-10R treatment. CX3CR1int CD64&plus; MNPs selectively expressed a variety of pro- and anti-inflammatory genes, including a number of genes which individually can both promote and negatively regulate inflammation. IL-23 is essential for Hh &plus; anti-IL-10R-induced intestinal pathology. We investigated the role of MNPs as a source of IL-23 which drives Hh &plus; anti-IL-10R colitis. Unexpectedly, our results indicate that normally hyporesponsive CX3CR1hi macrophages may act as the initial source of IL-23, which induces development of colitis. Recruitment of Ly6C&plus; MHCII&plus; MNPs to the lamina propria was IL-23-dependent, and these cells also expressed IL-23, which may establish a positive feedback loop of immune cell recruitment, activation and IL-23 production. Finally, we also examined how MNPs might be recruited to the colonic lamina propria during inflammation. Our studies support the conclusion that CCR6 is not required for accumulation of monocyte-derived populations in the inflamed intestine. We cannot rule out a role for CCR2, however preliminary data from the Hh &plus; anti-IL-10R colitis model suggest a potential role for CCR1 or its close relation CCRL2. Such pathways could represent new therapeutic targets in inflammatory bowel disease.
A burning question
Keywords: Cremation
Radiocarbon
Isotopes

Cremated bone occurs in many archaeological sites as small grey and white fragments. The high temperatures reached during heating induce structural, chemical and isotopic changes to bone apatite (the inorganic fraction of bone). These changes are investigated here by infrared spectroscopy and mass spectrometry (δ13C, δ18O and 87Sr/86Sr) in both modern heated bone and archaeological cremated specimens. The results of various heating experiments (in laboratory and natural conditions) highlight the significant carbon and oxygen exchanges with the fuel used as well as with bone organic matter (mainly collagen). While not informing on dietary practice and hydrology as is the case with unburned bone, the δ13C and δ18O values of calcined samples together with infrared results provide information on the conditions in which the bone was heated (e.g. presence of fuel, size of the pyre, temperatures reached, dry or fresh bone, etc.). In parallel, the effect of heat on the strontium present in bone is minimal, if not undetectable. Furthermore, as observed through artificial contamination experiments, post-burial alterations also appear to be extremely limited, which is to be expected due to the higher crystallinity of calcined bone apatite compared to tooth enamel and unburned bone. These experiments demonstrate that calcined bone provides a reliable substrate for mobility studies using its strontium isotope composition. The application of these results to the study of six Neolithic and one Bronze Age sites from Ireland showed the possibility of discriminating cremated individuals that ate food originating from different regions, as well as highlighting possible variations in cremation practices between different sites. The results of this thesis greatly extend the application of strontium isotopes to places and periods in which cremation was the dominant mortuary practice, or where unburned bone and enamel do not survive. They also provide insights into the reconstruction of ancient cremation practices.
Festal apologetics : Syriac treatises on the Feast of the Discovery of the Cross
Keywords: Moshe bar Kepha
David Eskolaya
Jacob of Serugh
John of Dara
veneration of the cross
Feast of the Discovery of the Cross
Jewish-Christian relations
apologetics
liturgical year
Narsai
Dionysius bar Salibi
Muslim-Christian relations

This thesis argues that the Feast of the Discovery of the Cross offered an occasion to refute religious opposition to the cross and crucifixion in the diverse socio-political contexts encountered by Syriac Christians between the fourth and the ninth centuries. At its inception, the Feast of the Cross promoted the cult of the True Cross, Old Testament typology, and the expansion of the Christian faith, and these features were sufficiently malleable to meet new religious challenges and political contexts. John of Dara’s ninth-century homily On the Cross is a lengthy exposition on the veneration of the cross, and it showcases how the feast could be used for apologetic ends. The first chapter focuses on the relic of the True Cross and the theologies of the cross of Eusebius of Caesarea, Cyril of Jerusalem, and Ephrem the Syrian, which shaped later festal celebrations. The second chapter traces the development of the legend of Helena’s Invention of the Cross and introduces the most popular Syriac invention legends, the Protonike and Judah Kyriakos legends. The third chapter analyses themes in pre-Arab Conquest Syriac homilies for the Feast of the Cross by Narsai, David Eskolaya, Jacob of Serugh, Severus of Antioch, and Pseudo-Chrysostom. The fourth chapter provides an overview of the dramatic changes of the seventh century during the reign of Heraclius and following the Arab Conquest. Chapter five compares inter-religious debate concerning the cross and crucifixion between Christians and Jews and between Christians and Muslims between the seventh and ninth centuries. Chapter six introduces John of Dara’s homily for the Feast of the Cross, which uses the traditional themes, together with apologetic topics, to defend the veneration of the cross. Chapter seven explores the influence of John of Dara’s homily on later Syrian Orthodox writers, Moshe bar Kepha and Dionysius bar Ṣalībī.
Elected Police and Crime Commissioners: an experiment in democratic policing
Keywords: Police

In this thesis, I explore the ways in which Police and Crime Commissioners (PCCs) have met a declared policy intention to create greater democratic accountability around policing and crime. I conceptualise PCCs as a piece of a broader democratic puzzle and explore both how they have been positioned and shaped within the broader policing and crime nexus across England and Wales. In considering the positioning of PCCs, I use data from case studies and interviews with 32 (out of 41) PCCs to identify how they have begun to develop relationships with the public and local, regional and national partners. The findings suggest that with the exception of their abilities to join up local crime reduction services, PCCs occupy an awkward space – not local enough to be meaningfully representative of the public they serve, but not outwardly-facing enough to manage wider co-ordination of policing. Subsequently, I investigate the shape of the PCC model to deliver greater accountability by focusing on the ways in which PCCs have begun to envisage the role and develop relationships with other key stakeholders. Varied responses from PCCs across the country reflected the broad-ranging nature of the role, which in some cases appeared to undermine their ability to fully perform all aspects of the job. I argue that this became particularly accentuated in emerging relationships with chief constables and Police and Crime Panels, where the single PCC model exposes accountability to dangers of personalities and politics. I conclude by arguing that while many PCCs have facilitated various components of democratic accountability within the management of policing and crime-reduction services, the PCC model appears to be misplaced and misshaped to effectively complete the puzzle of democratic policing.