VictorJuiz/thesis huggingface dataset:
A Trace of Genocide: Racialization, Internal Colonialism and the Politics of Enuncation
Keywords: racialization
internal colonialism
moral welfare work
eugenics
pathologization
Barnardo's
nation state and Britain

This analysis examines the implicatedness of the self as an embodied space of marginality, knowledge, and resistance to the discursive and material effects of systemic oppression. It explores the implications and possibilities as they relate to social collectives [in nation-state contexts] in resisting and contesting the constraining forces of dominant/dominating institutionalized power and authority in the context of speaking and/or enunciating from the space of abjectification, racialization, and outcastness that has been constructed historically by the nation-state of Britain as a body codified as included-as-excluded-as-removed from the dominant sociopolitical collective’s sense of self and identity? This study argues that enunciation in this form carries with it a politics of ontological transformation that has profound implications for the social collective that is Britain as a whole specifically in the context of social justice affirmation and the reclamation [and assertion] of a collective sense of self that is grounded in a refusal and contestation of the multi-layered hegemonic conceptual frameworks that continue to naturalize, {re}produce and sustain systemic oppression as a state of permanency [Bell, 1992]. This study will explore the permanency of oppression further in relation to the discursive and material negation and amputation of social difference [i.e. class, gender, disability, and sexuality] while centering race [and its prostheticization] as a salient organizing tool in the (re)production of a hegemonic social order. To this end this study utilizes two key interconnecting concepts, internal/internalized colonialism, and racialization. ii It suggests that racialization mediated and channeled by and through a process of internal/internalized colonialism underpins the hegemonic social order of Britain and as such both terms are re-conceptualized and subjected to a complex analysis. Finally, this study examines the theoretical possibilities for developing an anti-racialization framework as a politics of enunciation that makes usage of the concept of racialization as a tool for [1] demystifying systems of oppression, [2] understanding the processes of collective implicatedness in oppression, [3] refusing pathologization and [4] mobilizing transformation through and within a refusal of the amputative and negative capacities of the racialization process.
Proliferation and Potential of Neural and Retinal Stem Cells
Keywords: Stem cell
forebrain
retina

The term “stem cell” is often broadly applied to a range of cell types that are relatively undifferentiated and have some capacity for proliferation. In this thesis, I employ a strict definition of stem cells as cells that are capable of both self-renewal and multilineage differentiation. These properties are tested in single precursor cells from the forebrain and its derivative, the retina, using clonal assays. Poor survival is a common problem in single cell cultures, and I show that low oxygen dramatically improves viability in neural stem cells clonally derived from mouse embryonic stem cells, as well as in cultured forebrain neural stem cells. Caspase-dependent and apoptosis-inducing factor-dependent cell death pathways were found to be differentially influenced in low oxygen culture of early, primitive and later, definitive neural stem cells. I isolate precursors from 2 separate regions of the adult mouse forebrain, the lateral ventricle and the hippocampus and argue that only cells resident in the lateral ventricle can be classified as stem cells while the hippocampus contains restricted progenitor cells. Unlike neural stem cells, the very existence of retinal precursors in the adult mammal is controversial. I investigate methods to prospectively identify a rare stem cell population in the pigmented ciliary epithelium of the adult mouse eye and show that, although this population intrinsically gives rise to all retinal cell types, cells can be directed specifically towards a photoreceptor fate by the addition of exogenous factors to the culture media. Pigmentation of retinal stem cells is used as a convenient marker to isolate a retinal stem cell from human embryonic stem cells differentiating under conditions known to promote neural differentiation. Retinal stem cells derived from human embryonic stem cells have highly similar properties to those directly isolated from the eye, and their progeny can similarly be driven to differentiate into photoreceptors. The findings presented in this thesis help to define intrinsic properties of adult neural and retinal precursors and provide a basis for manipulating these cells, potentially for future use in clinical applications.
Search for Contact Interactions using Dijet Angular Distributions with the ATLAS Detector at the CERN Large Hadron Collider
Keywords: Dijet Angular Distributions
Contact Interactions

The LHC, with its center-of-mass energy of 7 TeV, offers the chance to investigate the fundamental constituents of matter at a higher energy scale than ever before. Using the data acquired by the ATLAS detector in the summer of 2010, two different measures of the angular distributions of dijet final states are studied and compared to Standard Model QCD expectations. Such a comparison is used to set new stringent limits on the existence of quark substructure.
Family Members' Use of Private Companions in Nursing Homes: A Mixed Methods Study
Keywords: Private Companions
Nursing Homes
Quality of Care
Caregiving

Families who are dissatisfied with the nursing home care of their family member may supplement their care by hiring a private companion. Families who have the financial resources pay for extra care, while families who cannot afford a private companion receive the current standard of care. Anecdotal evidence suggests that private companion use has increased over time. However, there is no research that examines private companions. The goal of this mixed methods study was to provide empirical evidence about who private companions are, what they do, and why they are needed. Andersen and Newman’s Health Service Utilization Model was used to understand private companion use. This study used both survey research and grounded theory. A mailed survey was completed by 280 of 432 family members of nursing home residents in a Toronto nursing home, yielding a response rate of 65 percent. Grounded theory principles were used to conduct interviews with 10 family members to understand why private companions were hired. Almost two-thirds of nursing home residents had a private companion. Family members reported that they paid about $475 per week for private companions who provided about 40 hours of care per week. Private companions were mostly women and immigrants. Private companions performed many activities including assisting with activities of daily living, toileting, feeding, escorting to activities, and providing social support. In the survey, family members reported hiring a private companion for reasons related to families’ needs (e.g. quality of care concerns), residents’ needs (e.g. deteriorating health); and staff recommendations. The family members reiterated these reasons in the interviews. Quality of care was the overarching theme that captured the reason for private companion use, which encompassed the following themes: inadequate staffing, unmet residents’ needs, overburdened family members, and suboptimal nursing home environment. The qualitative data emphasized the importance of building relationships with nursing home residents. The predictors of private companion use in the multivariate analysis were longer duration of nursing home stay, higher resident dependency, and family members’ concerns with quality of care. This research is among the first to study private companions, and has implications for research, policy, and practice.
Otherworld - Giving Applications a Chance to Survive OS Kernel Crashes
Keywords: Operating Systems
Reliabiltiy
Fault Tolerance
Microreboot

The default behavior of all commodity operating systems today is to restart the system when a critical error is encountered in the kernel. This terminates all running applications with an attendant loss of "work in progress" that is non-persistent. Our thesis is that an operating system kernel is simply a component of a larger software system, which is logically well isolated from other components, such as applications, and therefore it should be possible to reboot the kernel without terminating everything else running on the same system. In order to prove this thesis, we designed and implemented a new mechanism, called Otherworld, that microreboots the operating system kernel when a critical error is encountered in the kernel, and it does so without clobbering the state of the running applications. After the kernel microreboot, Otherworld attempts to resurrect the applications that were running at the time of failure. It does so by restoring the application memory spaces, open files and other resources. In the default case it then continues executing the processes from the point at which they were interrupted by the failure. Optionally, applications can have user-level recovery procedures registered with the kernel, in which case Otherworld passes control to these procedures after having restored their process state. Recovery procedures might check the integrity of application data and restore resources Otherworld was not able to restore. We implemented Otherworld in Linux, but we believe that the technique can be applied to all commodity operating systems. In an extensive set of experiments on real-world applications (MySQL, Apache/PHP, Joe, vi), we show that Otherworld is capable of successfully microrebooting the kernel and restoring the applications in over 97\% of the cases. In the default case, Otherworld adds negligible overhead to normal execution. In an enhanced mode, Otherworld can provide extra application memory protection with overhead of between 4% and 12%.
The Managerial Roles of Academic Deans in Ontario
Keywords: academic dean
managerial role

This thesis examines the managerial roles of the academic deans in Canadian universities, particularly in the province of Ontario. It is important to study the roles of the academic deans since they are pivotal to any higher education institution’s success. Research indicates that organizational performances are very much influenced by what happens in the middle of organizations rather than at the top. (Currie and Procter, 2005) As middle managers, deans are compelled to manage both people and results, while providing vital links to the organization when translating top-level directives of the upper management – president, vice-president academic etc. - into operational plans that need to be understood and implemented by the departmental chairs and program coordinators. Understanding the roles of the academic deans within the context of new public management ideologies will help to increase our understanding about how universities are run and what challenges are presently being faced. The study involved participants from 15 Ontario universities. An online survey has been used in order to collect the data. The response rate was 39%, 41 academic deans out of 105 provided their input between May –July 2009. The data collected was subjected to a quantitative analysis which included descriptive statistics and correlation analysis. The findings confirmed the fact that the role of the academic dean has become more managerial in nature as Canadian universities are moving more towards a managed professional public organization model.
On a Universal Finite Type Invariant of Knotted Trivalent Graphs
Keywords: finite type invariants
knotted trivalent graphs
Kotsevich integral
Drinfeld associator

Knot theory is not generally considered an algebraic subject, due to the fact that knots don’t have much algebraic structure: there are a few operations defined on them (such as connected sum and cabling), but these don’t nearly make the space of knots finitely generated. In this thesis, following an idea of Dror Bar-Natan’s, we develop an algebraic setting for knot theory by considering the larger, richer space of knotted trivalent graphs (KTGs), which includes knots and links. KTGs along with standard operations defined on them form a finitely generated algebraic structure, in which many topological knot properties are definable using simple formulas. Thus, a homomorphic invariant of KTGs provides an algebraic way to study knots. We present a construction for such an invariant. The starting point is extending the Kontsevich integral of knots to KTGs. This was first done in a series of papers by Le, Murakami, Murakami and Ohtsuki in the late 90’s using the theory of associators. We present an elementary construction building on Kontsevich’s original definition, and discuss the homomorphicity properties of the resulting invariant, which turns out to be homomorphic with respect to almost all of the KTG operations except for one, called “edge unzip”. Unfortunately, edge unzip is crucial for finite generation, and we prove that in fact no universal finite type invariant of KTGs can intertwine all the standard operations at once. To fix this, we present an alternative construction of the space of KTGs on which a homomorphic universal finite type invariant exists. This space retains ii all the good properties of the original KTGs: it is finitely generated, includes knots, and is closely related to Drinfel’d associators. The thesis is based on two articles, one published [Da] and one preprint [BD1], the second one joint with Dror Bar-Natan.
Gender and Occupational Riskiness
Keywords: gender
displacement
occupational choice

In this thesis I investigate the relationship between the gender distribution across industries and occupations and the incidence and consequences of displacement. First, I provide empirical evidence to support the idea that women self-select into less risky industries and occupations, that is industries and occupations with lower displacement rates and lower earnings growth. Using data from the Displaced Worker Survey (1984-2002), the corresponding Annual Demographic Supplement to the March Current Population Survey, and the Dictionary of Occupational Titles, I find that, even though women have a lower incidence of displacement in the aggregate, they are more likely to get displaced at the one-digit industry and occupation level than men. Displacement is also more costly for women, in terms of both employment and monetary consequences, which suggests that women’s choice of safer sectors could be an insurance mechanism against the risk of displacement and its costly consequences. I then construct a dynamic occupational choice model in the spirit of Keane and Wolpin (1997), in which occupation(industry) groups differ not only in terms of the rate of human capital accumulation, but also in the risk and associated cost of displacement, as well as in the value of the non-monetary utility component. I calibrate the model for men and perform a number of counterfactual experiments for women. Quantitative results suggest that differences in displacement probabilities, together with differences in re-employment probabilities, and in human capital penalty rates at displacement explain up to 15% of the gender occupational segregation, and up to 10% of the gender industry segregation. Allowing women to also have an extra preference for non-employment explains in a proportion of 60% why women avoid high risk occupations, that is occupations with higher displacement risk, higher earnings growth and higher human capital depreciation (or alternatively, lower human capital transferability).
Structural Evolution of Quiescent Galaxies from the Peak of the Cosmic Star Formation Epoch
Keywords: extragalactic astronomy
galaxy evolution
elliptical galaxies
fundamental parameters
astronomical techniques
astronomical instrumentation
astrophysical data

The main focus of this thesis is the investigation of an interesting new population of massive passively evolving galaxies found at high redshifts. We use a sample of these galaxies at redshifts 1<z<2 drawn from the Gemini Deep Deep Survey sample and measure their structural parameters based on the Hubble Space Telescope imaging in the rest frame visible and ultraviolet wavelength range. Our analysis shows that a fraction of these systems are very compact, with effective radii of R_e<1 kpc, even when observed in rest frame visible light. The average size of these objects is 2-5 times smaller than the typical size of an early-type galaxy of similar mass found locally. We combine the results from our morphological analysis with data from published spectroscopic samples of quiescent systems with known structural parameters. Analysis of these data for galaxies over the redshift range 0<z<2.5 shows that passively evolving galaxies are continuously and gradually growing in size. We also find smooth evolution of the stellar mass density within the central kiloparsec of these systems. The stellar mass density grows by a factor of 3 from z=0 to z~2.5. None of the models proposed to drive the structural evolution of early-type objects can explain all the observed aspects of this process. Because these massive compact galaxies have such small angular sizes, future studies of these systems will benefit from adaptive optics. In order to compile a large statistical sample of these objects suitable for adaptive optics follow-up, we first need to find a large number of targets with nearby bright natural guide stars. As a first step in this process, we describe the properties of a set of one square degree regions of the sky we have located that have a rare combination of high stellar surface density and low levels of extinction. We demonstrate that the adaptive optics-related properties of these fields are in some cases orders of magnitude better than those of existing deep fields.
Understanding Synthetic Speech and Language Processing of Students with and without a Reading Disability
Keywords: Text-To-Speech
Reading Disability
Assitive Technology
Learning Disabilities

To help circumvent reading disability (RD) decoding difficulty, Text-To-Speech (TTS) software can be used to present written language audibly. Although TTS software is currently being used to help RD students, there is a lack of empirically supported literature to inform developers and users of TTS software on best practices. This dissertation investigated two methods to determine whether they increase the effectiveness of TTS for RD and typically-developing students. The first method compared low and high quality TTS voices in regards to understanding. TTS voice quality was identified by having 40 university students listen to and rate the quality of 10 commonly used TTS voices and 2 human voices. Three voices were chosen for the subsequent study based on the ratings; one low quality TTS, one high quality TTS, and one natural voice (Microsoft Mary, AT&T Crystal, and Susan, respectively). Understanding was assessed with tests of intelligibility and comprehensibility. Forty-five grade 6 to 8 students who were identified as having a RD were compared to same-age typically-developing peers. Results showed high quality TTS and natural voice were more intelligible than the low quality TTS voice, and high quality TTS voice resulted in higher comprehensibility scores than low quality TTS and natural voice. The second method investigated whether it is possible to increase a student’s comprehension when using TTS by modifying the presentation style of the TTS voice. The presentation style was manipulated in two ways: varying the speed at which the TTS presented the materials (120, 150, 180 words per minute) and the presence of pauses varied (no pauses inserted, random pauses inserted, or 500 millisecond pauses at the end of noun phrases). Due to a floor effect on the comprehension of the texts the expected results were not obtained. A follow up analysis compared the participants’ prosodic sensitivity skills based on whether they had a specific language impairment, (SLI) a reading impairment (RI), or were typically-developing. Results suggested that SLI has significantly less auditory working memory then RI impacting their auditory processing. Recommendations for future research and the use of TTS based on different learning profiles are provided.
Identification and Analysis of the Folding Determinants of Membrane Proteins
Keywords: membrane proteins
folding

Membrane proteins are responsible for a variety of key cellular functions including transport of essential substrates across the membrane, signal transduction, and maintenance of cellular morphology. However, given the size and high hydrophobicity of membrane proteins, along with demanding expression and solubilization protocols that often preclude biophysical studies, novel approaches must be devised for studies of their structure and function. This thesis addresses these issues through several sets of inter-related experiments. We first examine sequence motifs directing -helix packing, wherein the determinants of glycophorin A (GpA) dimerization were identified via TOXCAT assay and the evaluation of GpA-derived peptides. We found that (i) conservative mutations can have significant effects on the oligomerization of glycophorin A; and (ii) residues that introduce more efficiently packed structures that are poorly solvated by lipid leads to improved transmembrane segment dimerization. In a further study, we inquired into the criteria for selection of membrane-spanning -helices by cellular machinery through investigation of hydrophobic helical segments (termed -helices) that we identified in soluble proteins. We found that the number and location of charged residues in a given hydrophobic helix are related to their insertion propensity as membrane-spanning segments. When we applied this criterion to -helices in their intact protein structures, we successfully determined the extent of -helix mutations necessary to convert a soluble protein, in part, to a membrane-inserted protein. Finally, using a three-transmembrane segment construct from the cystic fibrosis transmembrane conductance regulator (CFTR), we performed experiments aimed at optimizing criteria for protein overexpression, including construct design, choice of expression system, growth media, and expression temperature. The overall findings are interpreted in terms of progress towards defining the fundamental characteristics of membrane-spanning -helices - from their primary amino acid sequence to the helix-helix interactions they display in the assembly of biologically-functional membrane protein structures.