VictorJuiz/thesis huggingface dataset:
Measuring Highway Work Zone Throughput
Keywords: Work Zone
Throughput
Capacity
Road Construction

The focus of this project is highway construction zones and the impact of lane closures on traffic. By measuring throughput (the number of vehicles that can flow through a work zone in a given amount of time), analysis was performed to determine the factors that affect this value. Successful data collection uncovered a paradox. Often work zones would see no queuing, indicating the lane could have been closed for longer hours. Alternatively sites with forced flow allowed fewer vehicles through the site than expected, indicating that the design value is too high, requiring shorter lane closure hours. A generic model for throughput was developed as well as a better functioning highway specific model. In addition to these models, this project developed a spreadsheet-based form of analysis named SZUDA (Simplified work Zone User Delay Analysis) that determines queue length and approximate costs associated with road user delay.
Functional Hydration and Conformational Gating in the D-channel of Cytochrome c Oxidase
Keywords: water-mediated proton transport
free energy simulations
protein hydration

Cytochrome c oxidase couples the reduction of dioxygen to proton pumping against an electrochemical gradient. The D-channel provides the principal uptake pathway for protons. A water chain is thought to mediate the relay of protons through the D-channel, but it is interrupted at N139 in all crystallographic structures. Here, free energy simulations are used to examine the proton uptake pathway in the wild type and in single-point mutants N139V and N139A, where reduction and pumping is compromised. A general approach for the calculation of water occupancy in protein cavities is presented and demonstrates that combining efficient sampling algorithms with long simulation times is required to achieve statistical convergence of equilibrium properties in the protein interior. The relative population of conformational and hydration states of the D-channel is characterized. Results shed light onto the role of N139 in the mechanism of proton uptake and clarify the physical basis for inactive phenotypes.
The Influence of Age and Sector on the Occupational Therapists Labour Market in Ontario
Keywords: Health Care Management
Rehabilitation and Therapy
Labor

The purpose of this thesis was to analyze factors related to labour market survival and withdrawal behaviour in the profession of Occupational Therapy in Ontario from 1997 to 2006. To provide a portrait of the OT labour market in Ontario overall, and in relation to sector and age, three types of analysis were used: descriptive statistics (including “stay, switch, and leave” analysis), “Stickiness” and “Inflow” analysis, and survival analysis. The largest proportion of OTs worked in the Hospital sector, which had a great ability to retain OTs according to the “Stickiness” analysis. However, when controlling for other variables using survival analysis, none of the sector variables had a significant effect on survival. The youngest and oldest age groups had the highest propensity of leave, due to mobility, family commitments, and retiring (oldest group only). Overall, the profession in Ontario had a strong ability to retain OTs working in the profession during the study period.
Using Repositories for Ontology Design and Semantic Mapping
Keywords: ontologies
ontology repository
semantic mapping
ontology reuse
ontology design
knowledge engineering

There are two significant impedances to the realization of the potential of ontologies. First, many ontology designers lack the necessary background in formal logics to express their intuitions clearly and precisely, resulting in the proliferation of ontologies with low expressivity. Concurrently, developing semantic mappings between existing ontologies is difficult, because much of the semantics is external to the representation. This thesis uses the idea of metaphor to develop architectures for ontology repositories to serve as bottom-up reusable resources. Moreover, an ontology design algorithm has been developed that allows designers to communicate their ideas at the semantic level, simply by generating and vetting models. Finally, a semantic mapping algorithm has been developed that uses an ontology repository to determine the similarities and differences between any number of target ontologies. An ontology for partial orders has been elaborated to demonstrate the proof of concept and populate the first iteration of the repository.
Role of Simulation in Rehabilitation: The Effectiveness of Model Hands When Learning to Make Othoses
Keywords: Simulation
Education
Rehabilitation
Orthoses
Motor learning

Simulation has not been extensively studied for teaching rehabilitation practitioners technical skills. The purpose of this study is to test the efficacy of an artificial hand as a teaching tool for orthosis-making. Thirty-four participants were randomized into three groups. The first group made five orthoses on a human hand, the second made five orthoses on a model hand, and the third made one orthosis on a human hand. A one-week transfer test consisted of all participants making one orthosis on a human hand. Their performance and orthoses were evaluated using a validated checklist and global rating scale. No differences were found between groups for process-related measures. The model hand group did better on final product measures and had a larger movement time than the other two groups. Practicing on artificial hands is a useful way of learning to make orthoses. Additionally, higher practice volume did not lead to better performance.
An 8-bit, 12.5GS/s Folding-interpolating Analog-to-digital Converter
Keywords: An 8-bit, 12.5GS/s Folding-Interpolating Analog-to-Digital Converter
high speed ADC
shoreh ghetmiri
Shohreh Ghetmiri
C.A.T Salama
Folding interpolating ADC
8 bit SiGe ADC
IHP ADC

The motivation behind this work is to target the demand for high-speed medium-resolution ADCs for satellite communication systems. An 8-bit, 12.5GS/s folding-interpolating ADC was designed in 0.25µm, 190GHz SiGe BiCMOS technology from IHP. The ADC consists of a THA, a reference resistor ladder, folding amplifiers, an interpolating resistor string, a comparator array, a digital encoder, a coarse quantizer and a bit synchronizer. Post-layout simulation results of the ADC verify that its performance meets all the required specifications. By comparison to other high-speed ADCs, implemented in SiGe technologies, the present design features the highest sampling rate for 8-bit resolution ADCs to date with a good FOM (12.9pJ/conversion). The THA and the comparator were implemented experimentally and characterized to verify their performance and to ascertain the possibility of implementing the complete ADC. The experimental results meet the expected specifications and indicate that both circuits are suitable for the implementation of the ADC.
The Effect of Speaking Rate on Velopharyngeal Function in Healthy Speakers
Keywords: speaking rate
velopharynx
velum
velopharyngeal function
soft palate
VP

This study investigated the effect of speaking rate on aerodynamic and acoustic measures of velopharyngeal (VP) function in 27 adult speakers (14 M, 13 F). The pressure-flow method (Warren & Dubois, 1964) was used to collect aerodynamic data of /m/ and /p/ segments in the word “hamper” and the utterances “Mama made some lemon jam” (MMJ) and “Buy Bobby a puppy” (BBP). A Nasometer was used to collect nasalance scores and nasalance distance for MMJ and BBP. Measures were collected under 4 speaking rate conditions (normal, fast, slow, and slowest). Results indicated that nasal airflow and VP orifice area were unaffected by speaking rate whereas intraoral pressure decreased as speaking rate slowed. Nasalance was greater for BBP at slow speaking rates and nasalance distance (MMJ – BBP) decreased at slow rates. The data was interpreted with respect to expectations set forward in the literature on normal and disordered speech motor control.
Comparisons between MATSim and EMME/2 on the Greater Toronto and Hamilton Area Network
Keywords: agent-based micro-simulation modelling
MATSim
EMME
traffic assignment

The agent-based micro-simulation modelling technique for transportation planning is rapidly developing and is being applied to practice in recent years. In contrast to conventional four-step modelling with static assignment theory, this emerging technique employs a dynamic assignment principle. Based on summary of various types of traffic assignment models and algorithms, the thesis elucidates in detail the theories of two models, MATSim and EMME/2, which represent two genres of traffic assignment, i.e., dynamic stochastic stationary state assignment and static deterministic user equilibrium assignment. In the study, the two models are compared and validated to reflect both spatial and temporal variation of the traffic flow pattern. The comparison results indicate that numerical outputs produced by MATSim are not only compatible to those by EMME/2 but more realistic from a temporal point of view. Therefore, agent-based micro-simulation models reflect a promising direction of next generation of transportation planning models.
Modulation of TGF‐β Receptor 1 signalling in Live Cells
Keywords: TGF-β Inhibition
Peptide
ATP competitive inhibitor
neutralzing antibody

TGF-β negatively affects the maintenance and expansion of hematopoietic stem cells ex vivo and its inhibition has been widely studied as a treatment for numerous hematopoietic disorders and cancers. Current inhibitory strategies (small molecule ATP competitors and neutralizing antibodies) are compared to a novel cell-permeable peptide-based inhibitor of TGF-β RI. Multiple levels of assay from biochemical to functional are utilized with the aim of applying the most successful inhibitor to hematopoietic stem cell culture. The neutralizing antibody proved ineffective in the short-term biochemical assay but was extremely effective at neutralizing TGF-β signalling in proliferation and hematopoietic colony-forming cell assays with no evidence of toxicity. The small molecule inhibitors (SD-208 and Pyrazole TGF-β RI inhibitor) were equally effective at micromolar levels in all forms of assay, with SD-208 being slightly more potent. The novel peptide inhibitor proved ineffective in all assays, which is likely a result of its rapid degradation in live cells.
An In Vitro Model System For Cardiac Cell Therapy
Keywords: Cardiac Tissue Engineering
Embryonic Stem Cells
Cell Therapy
In Vitro Model

Embryonic stem cells (ESC) constitute a promising source of cells for cardiac transplantation strategies. However, complexities associated with in vivo studies have made it difficult to develop a thorough understanding of cell integration. We have engineered an in vitro system that recapitulates the native cardiac environment using 300μm thick collagen scaffolds seeded with neonatal cardiomyocytes (CM) and electrical field stimulation. The injection of undifferentiated ESC served as a baseline to assess the validity of studying cell transplantation in this model. Yfp-ESC survived and proliferated over several days in model tissue. ESC were not observed to significantly differentiate into the cardiac lineage, and did not integrate with the cardiac cell population. While the injection of ESC improved cardiac cell number, tissue functional properties were hindered. The methods developed herein can be readily adapted to study ESC derived progenitor and differentiated cells, to elucidate the optimal cell state for ESC-mediated cell therapy.
Encouraging Energy Conservation Through Information Display: A New Approach
Keywords: behaviour
behavior
feedback
conservation
information
display
energy
consumption
systematic
human
factors
engineering

Much study is required on how human behaviour affects resource consumption. Not only are Human Factors Engineers well equipped to study how to shape human behaviour, but contributors to conservation literature have asked for their involvement in the domain of energy conservation. This study took a novel, systematic, human-factors approach to providing feedback on energy consumption by testing the effects of providing three levels of feedback on conservation performance. The results showed that providing physical, functional, and task-based information aided performance more than physical information alone, but no more than providing physical and functional information together. More research is required to determine if physical and task information alone could achieve the same result, if study results would differ when two opposing task goals were given, and if the varying levels of feedback have a greater effect on novices.
The Effects of Population Density and Knock-downs of Llipid Metabolism Genes on the Expression of Cuticular Hydrocarbons in Drosophila melanogaser
Keywords: hydrocarbons
Drosophila melanogaster
pheromone
population density

In Drosophila melanogaster, chemical cues in the form of cuticular hydrocarbons play an important role in reproductive behavior. The social and genetic processes that regulate their expression, however, are poorly understood. The social environment has been shown to influence hydrocarbon display. In this study, the effect of population density on the expression of hydrocarbons was evaluated. I demonstrate that the production of certain hydrocarbons depends on the population density in which the animal is reared. Individual hydrocarbons fluctuate in quantity independently from one another but the peaks during a light-dark cycle are static depending mostly on chain length. The regulation of fly hydrocarbons which are density-dependent is shown to be sexually dimorphic. The RNAi knockdown of various putative lipid metabolism genes was also used to study hydrocarbon expression. This study reveals that lipid metabolism genes which are not obvious mediators of HC synthesis influence cuticular hydrocarbon profiles.
Spacecraft Thermal Design Optimization
Keywords: Spacecraft Design
Thermal Optimization
0756

Spacecraft thermal design is an inverse problem that requires one to determine the choice of surface properties that yield a desired temperature distribution within a satellite. The current techniques for spacecraft thermal design are very much in the frame of trial and error. The goal of this work is to move away from that procedure, and have the thermal design solely dependent on heat transfer parameters. It will be shown that the only relevant parameters to attain this are ones which pertain to radiation. In particular, these parameters are absorptivity and emissivity. We intend to utilize an optimal/analytical approach, and obtain a solution via optimization. As mentioned in the motivation, having a purely passive thermal system will greatly reduce costs, and our optimization solution will enable that. This topic involves heat transfer (conduction and radiation), spacecraft thermal network models, numerical optimization, and materials selection.
A Study of Soot Cake Formation in a Diesel Particulate Filter
Keywords: Diesel Emissions
Diesel Particulate Filter

A methodology was developed to dissect diesel particulate filters to study the time effect of loading for two different fuels: ULSD and a biodiesel blend. Filters loaded with soot from a diesel engine for exposure times of 1, 2, 5 and 10 hours were fractured and samples of filter substrates were analyzed using Raman spectroscopy and scanning electron microscopy. Observations revealed the sharp rise in pressure drop to be attributable to the clogging of the pores in the channel wall, leading to the formation of a pore-bridge. Cross sectional imaging of wall sections revealed this pore-bridge to be shallow, with significant particulate depositions limited to the first quarter of the depth of the filter walls. Images revealed increasingly dense deposits and the formation of coarse particles and soot cakes. Raman spectroscopy revealed no significant graphitization of the soot cake. The dissection methodology exhibits significant potential for future studies on DPFs.
Towards a Microfluidics-based Nucleic Acid Biosensor Using Immobilized Quantum Dot – DNA Conjugates for FRET Detection of Target Oligonucleotides
Keywords: Analytical
Chemistry

The potential for an electrokinetically driven, FRET-based microfluidic biosensor for SNP discrimination has been explored. The method functionalized the glass wall of a PDMS/glass microfluidics channel with multidentate thiol ligands to noncovalently immobilize MPA capped CdSe/ZnS QDs. Single stranded probe DNA could then be immobilized to QDs and target material could be delivered electrokinetically to the sensing surface. SNP discrimination could then occur by manipulation of shear, electrical and thermal effects derived from the applied voltage. The stability of immobilized QDs was investigated by EOF experiments that applied 500 V and 100 V voltages for 10 minutes to initiate electrokintetic flow. Fluorescence intensity measurements showed nearly complete removal of QDs from slides when compared with controls at both voltages. Pressure driven flow experiments demonstrated reduced dissociation of immobilized of QDs compared to channels exposed to EOF. A covalent approach is likely necessary to ensure stability of immobilized QDs during EOF.
Long-range Rover Localization by Matching Lidar Scans to Orbital Elevation Maps
Keywords: localization
mobile robotics
autonomy
space robotics

Current planetary rover localization techniques are lacking in autonomy and accuracy. An autonomous method of globally localizing a rover is proposed by matching features extractedvfrom a 3D orbital elevation map and rover-based 3D lidar scans. Localization can be further improved by including odometry measurements as well as orientation measurements from an inclinometer and sun sensor. The methodology was tested with real data from a Mars-Moon analogue site on Devon Island, Nunavut. By tying 23 real scans together with simulated odometry over a 10km traverse, the algorithm was able to localize with varying degrees of accuracy. Output uncertainties were large due to large input uncertainties, but these could be reduced in future experimentation by minimizing the use of simulated input data. It was concluded that the architecture could be used to accurately and autonomously localize a rover over long-range traverses.
Peptide Modification of Sodium Alginate To Induce Selective Capture of Cardiac Cell Populations
Keywords: alginate
cardiac
RGDS
adhesion
VAPG
REDV
microfluidics

Isolation of selected populations from heterogeneous cell mixtures and retrieval of the captured population of interest for regenerative medicine and diagnostics applications is one of the challenges that may be addressed by microfluidics. An affinity adhesion strategy was tested using the tetrapeptides RGDS (arg-gly-asp-ser), REDV (arg-glu-asp-val) and VAPG (val-ala-pro-gly) to modify an alginate hydrogel surface layer to selectively adhere fibroblast (FB), endothelial (EC) and smooth muscle cell (SMC) populations, respectively, of the non-myocyte cardiac cell fraction. Incorporation of peptides into sodium alginate gel surface coatings demonstrated a preferential, seeding density-dependent adhesion relationship on alginate-RGDS when tested with a cardiomyocyte-depleted cell suspension in both static culture and in microfluidic devices. Seeding density-dependent attachment was seen with close to 100% release of viable cells from coated surfaces upon application of ethylenediaminetetraacetic acid (EDTA). Further work will optimize the system with REDV and VAPG to capture ECs and SMCs.
HMG-CoA Reductase Inhibition Reduces T-cell Activation, TNFα Production, and MMP-9 Gene Expression in a Superantigen-mediated Mouse Model of Kawasaki Disease
Keywords: Kawasaki Disease
Statins

Kawasaki disease (KD) is a multisystem vasculitis leading to coronary artery aneurysm formation. In a superantigen-mediated murine model of KD, the development of coronary arteritis is mediated by T-cells through the production of TNFα. TNFα localizes to the coronary arteries, where it induces the expression of MMP-9, resulting in the breakdown of elastin and the formation of aneurysms. Statins have been recently shown to have anti-inflammatory and immunomodulatory properties as a result of the inhibition of small GTPases. In our murine model of KD, atorvastatin treatment inhibits superantigen mediated T- cell proliferation and cytokine production, including IL-2 and TNFα. Additionally, statin treatment inhibits TNFα-mediated MMP-9 production by vascular smooth muscle cells, through inhibition of the MEK/ERK pathway. Thus, statins modulate each of the critical steps in the pathogenesis of KD in a disease model, suggesting that statin use could alter the outcome and prognosis of children suffering with this disease.
A Diffusion Tensor Imaging Investigation of White Matter in Pediatric Multiple Sclerosis Patients
Keywords: Multiple Sclerosis
Diffusion Tensor Imaging
Pediatric
MRI

Background: To explore normal-appearing white matter (NAWM) in pediatric-onset multiple sclerosis (MS) patients, using diffusion tensor imaging (DTI). DTI study provides measures of WM integrity in adult MS patients. Pediatric MS patients provide a uniquely early window for exploring pathological components of myelin disruption. Methods: DTI data were obtained for 23 pediatric MS patients and 17 healthy children. Images were acquired using GE LX1.5T scanner (DTI parameters: 25 directions, 5mm slice thickness, b=1000s/mm2). Fractional anisotropy (FA) and apparent diffusion co-efficient (ADC) were analyzed in lesions and NAWM throughout corpus callosum (CC) and hemispheres. Results: Altered NAWM integrity in MS patients relative to controls is demonstrated by: reduced FA values (p<0.0001) and elevated ADC values (p<0.05) throughout CC and hemispheres. Conclusions: DTI measures show widespread disruption of WM integrity in children with MS extending beyond visible lesions. These findings implicate diffuse and potentially very early WM degeneration in MS pathobiology.
A 1Mbps 0.18μm CMOS Soft-output Decoder for Product Turbo Codes
Keywords: error correcting code
ECC
product turbo decoder
vlsi
hamming code

A product turbo code (PTC) decoder application specific integrated circuit (ASIC) is designed in 0.18μm 1P6M CMOS with embedded SRAM. From simulation, an operating frequency of 73.1 MHz at typical conditions is obtained, yielding a throughput of 3.8 Mbps with 4 decoding iterations, while consuming 103.4 mW. The total area is 5.13 mm2. Assuming the ASIC would be used as a hard macro, the area could be reduced to 1.7 mm2. The ASIC was tested at 20 MHz under typical conditions, which resulted in a throughput of 1.0 Mbps at 1.8V supply while consuming 36.6 mW. By making a slight modification, this design can be easily scaled to support IEEE 802.16d WiMAX. Allow for this, and moving to a 45nm process an estimated throughput of 9.44 Mbps with 4 iterations can be obtained. Total macro area would be approximately 0.11 mm2.