VictorJuiz/thesis huggingface dataset:
Rac GTPase Regulation of GLUT4 Traffic in Muscle Cells: Mechanisms and Implications
Keywords: Rac
GTPase
GLUT4
Insulin
Muscle
Actin

One of the hallmarks of postprandial glucose homeostasis is the ability of insulin to promote glucose uptake into skeletal muscles. Insulin achieves this feat by enhancing the recruitment of glucose transporter 4 (GLUT4) from an intracellular compartment to the plasma membrane of muscles in order to create a net increase in surface GLUT4, which results in elevated glucose uptake. From a molecular perspective, this insulin-regulated GLUT4 traffic action requires the independent activation of Akt and Rac-1 in muscle cells because perturbation of either molecule results in an impaired response. Although Rac-1 has been validated as key component of insulin response, its downstream signalling capacity contributing to GLUT4 translocation remains unexplored. Studies on Rac-1 have shown that it is responsible for the formation of cortical remodelled actin that facilitates GLUT4 translocation following insulin stimulation. However, the downstream Rac-dependent molecules governing this actin remodelling are undetermined. Here we identified Arp2/3 and cofilin as the Rac-dependent regulators of insulin-induced actin remodelling in muscle cells. While Arp2/3 acts to initiate a burst of actin polymerization, cofilin balances out the actin dynamics through its severing/depolymerizing activity. Inhibition of either molecule’s function leads to defective GLUT4 translocation mediated by insulin in muscle cells, suggesting the requirement of actin dynamics to facilitate GLUT4 traffic to the plasma membrane. Furthermore, given the importance of Rac-1 in insulin-mediate GLUT4 traffic, its application potential to reverse insulin resistance has never been explored. We discovered that providing muscle cells with additional Rac-1 activity produces an insulin-independent gain in surface GLUT4 with magnitude comparable to that normally elicited by insulin. This phenotype is accomplished because of the concomitant cross-activation of Akt pathway when supplying the cells with active Rac-1. Interestingly, this response can bypass signalling defects imposed by cellular insulin resistance conditions, leading to restoration of GLUT4 translocation in muscle cells. Overall, these results not only reinforce the functional impact of Rac-1 on GLUT4 traffic but also identify additional molecules governed by Rac-1 contributing to the integrity of this insulin-mediated response in muscle cells.
A Unified Geometric Framework for Kinematics, Dynamics and Concurrent Control of Free-base, Open-chain Multi-body Systems with Holonomic and Nonholonomic Constraints
Keywords: Open-chain multi-body systems
Kinematics
Hamiltonian dynamics
Differential geometry
Lie groups
Concurrent control

This thesis presents a geometric approach to studying kinematics, dynamics and controls of open-chain multi-body systems with non-zero momentum and multi-degree-of-freedom joints subject to holonomic and nonholonomic constraints. Some examples of such systems appear in space robotics, where mobile and free-base manipulators are developed. The proposed approach introduces a unified framework for considering holonomic and nonholonomic, multi-degree-of-freedom joints through: (i) generalization of the product of exponentials formula for kinematics, and (ii) aggregation of the dynamical reduction theories, using differential geometry. Further, this framework paves the ground for the input-output linearization and controller design for concurrent trajectory tracking of base-manipulator(s). In terms of kinematics, displacement subgroups are introduced, whose relative configuration manifolds are Lie groups and they are parametrized using the exponential map. Consequently, the product of exponentials formula for forward and differential kinematics is generalized to include multi-degree-of-freedom joints and nonholonomic constraints in open-chain multi-body systems. As for dynamics, it is observed that the action of the relative configuration manifold corresponding to the first joint of an open-chain multi-body system leaves Hamilton's equation invariant. Using the symplectic reduction theorem, the dynamical equations of such systems with constant momentum (not necessarily zero) are formulated in the reduced phase space, which present the system dynamics based on the internal parameters of the system. In the nonholonomic case, a three-step reduction process is presented for nonholonomic Hamiltonian mechanical systems. The Chaplygin reduction theorem eliminates the nonholonomic constraints in the first step, and an almost symplectic reduction procedure in the unconstrained phase space further reduces the dynamical equations. Consequently, the proposed approach is used to reduce the dynamical equations of nonholonomic open-chain multi-body systems. Regarding the controls, it is shown that a generic free-base, holonomic or nonholonomic open-chain multi-body system is input-output linearizable in the reduced phase space. As a result, a feed-forward servo control law is proposed to concurrently control the base and the extremities of such systems. It is shown that the closed-loop system is exponentially stable, using a proper Lyapunov function. In each chapter of the thesis, the developed concepts are illustrated through various case studies.
Effect of Multiple-choice Testing on Memory Retention – Cue-target Symmetry
Keywords: testing effect
retrieval practice
multiple-choice test
memory retention

This thesis investigated the testing effect, which is the tendency of testing to enhance learning and memory retention. Specifically, the thesis examines the extent to which test-induced retention benefits extend to the questions as well as the answers; are these benefits symmetrical? The results in the laboratory experiment (Experiment 1) demonstrated that the symmetry in retention benefits is highly dependent on the accuracy in the initial test. For the items students answered correctly in the initial test, the retention benefit was found to be symmetrical across the questions and answers supporting the retrieval hypothesis of the testing effect. However, for initially incorrect items, the retention performance was substantially better for the questions than the answers suggesting an asymmetrical effect from testing, a result that is also consistent with the retrieval hypothesis. These results were replicated using educationally-relevant materials with a delay up to five and a half months in two hybrid studies combining actual classroom experiences with controlled assessments in the laboratory (Experiment 2A & 2B). A series of follow-up studies were conducted to examine the difference in retention performance of the questions and the answers for the initial incorrect items. Particularly, the experiments focused on investigating various factors that might contribute to or eliminate the difference in retention performance, including prior study (Experiment 3), verification feedback (Experiment 4A & 4B) and answer feedback (Experiment 5). The thesis also touched upon various issues related to the temporal dimension of the testing effect. The previous notion that testing slows down forgetting rate is not supported by the data. Instead, testing seems to provide a short-term insulation against immediate forgetting, but then memory for the tested materials decays in the same way as the non-tested materials.
Mahjonging Together: Distribution, Financial Capacity, and Activities of Asian Nonprofit Organizations in Canada
Keywords: ethnic community
nonprofit organizations
transnationalism
Asian Canadian

Using a nationwide database of nonprofit organizations, this thesis examines the impact of the socio-spatial environment and resource dependency on the development of ethnic organizations among four East Asian communities (Chinese, Japanese, Korean and Vietnamese) across Canadian cities. The thesis makes an original contribution to the theoretical understanding of ethnic communities by evaluating the different perspectives for understanding three related but distinct properties of ethnic organizations (1) distribution – the number of organizations in a given city; (2) financial capacity – total revenue of the organization; and (3) cross-border activities – location and type of activities pursued outside of Canada. The findings suggest that organizations develop more in response to social need rather than group resource, and that the number of organizations is greater in cities where levels of residential concentration are high. The analysis shows that group characteristics such as income and size of enclave do not predict higher revenue among nonprofits. Rather, the effect of government funding is the most consistent predictor of financial capacity across all groups. Overall, the results highlight the importance of inter-group dynamics for institutional development, with traditional predictors such as group resource playing a lesser role. In regards to their activities, the results show that organizations of recent immigrant groups do not necessarily operate programs back home as some groups have more programs in places outside their home country. Additionally, source of funding and religion play a role in determining the location of cross-border activities. These findings challenge the current perspective on transnational linkages as ethnic organizations have the power to mediate group interests away from the host-home nexus. Together, the research offers a novel empirical approach to examine how groups organize at the community level and provides an alternative perspective in the understanding of integration, social cohesion and sense of belonging in multicultural societies.
The Welfare State and Socioeconomic Inequalities in Women’s Health Dynamics: A Comparative Study of Four OECD Countries
Keywords: comparative
feminist welfare state theory
education level

While it is known that social policies influence the organization of employment and family life, this knowledge is rarely used to understand women's health. The current study uses feminist welfare state theory to examine socioeconomic inequalities in women's health dynamics in countries differing by the extent to which their social policies encourage male breadwinning and female caring/homemaking. The pathways underlying these inequalities are also investigated. Socioeconomic inequalities in health are hypothesized to be largest in strong male-breadwinner states (Britain/Germany), smallest in weak male-breadwinner welfare states (Denmark), and intermediate in modified male-breadwinner states (France). Further, family and income will explain more of health inequalities in strong and modified versus weak male-breadwinner regimes. The analysis uses longitudinal data from the European Community Household Panel (1994-2001) for working-aged women from Britain (n=2,193), Germany (n=2,421), France (n=2,400) and Denmark (n=1,412). The effects of socioeconomic position (measured by education) on self-rated health trajectories are examined using Latent Growth Curve Models; model estimates iii are compared cross-nationally using z-scores. Pathways linking education to health are identified by determining how much employment status, family roles and household income attenuate health inequalities in each country. The analyses are repeated for a sub-sample of mothers of young children—a group for whom policies surrounding the integration of employment and family are critical. Low education predicts worse initial health in all countries, but not faster health decline. Against expectations, education-based inequalities in health are largest in weak male-breadwinner states, but income explains virtually none of that inequality. By contrast, income has a larger explanatory role in regimes where women's unpaid caregiving is encouraged. Employment status is a relatively important mediator of the education-health relationship in all policy contexts, while family roles are not. Restricting the analysis to mothers reveals a much smaller education gradient in health in Denmark, providing evidence that weak male-breadwinner states are most effective at reducing health inequalities among mothers, relative to all women. Feminist welfare state theory better predicts cross-national differences in pathways underlying socioeconomic inequalities in health than the magnitude of inequalities, and may be most useful for understanding the health of mothers with young children.
Representations of Antonín Dvořák: A Study of his Music through the Lens of Late Nineteenth-century Czech Criticism
Keywords: Dvořák
Reception
Czech music
Criticism

Commenting on Antonín Dvořák (1841–1904), music critic Václav Juda Novotný declared in 1881 that “a Czech composer has to write, first and foremost, for a Czech audience.” Scholars have given considerable attention to Dvořák’s reception abroad and have shown that his path to success on foreign stages, particularly in Vienna, was not always direct. The composer’s reception in the Czech lands during the late nineteenth century was no less complicated – shaped by various cultural and political factors, as the Czechs sought to assert themselves in the fight for the nationalist cause, while remaining under Habsburg rule. Drawing on the wealth of newspaper and journal articles that were printed in the Czech press at this time, the dissertation places Dvořák’s music into its Czech context. The topic is explored by way of three case studies that deal with Dvořák’s contributions to choral, operatic, and symphonic genres. Each of the works examined came at a significant moment in Dvořák’s career in the Czech lands. The performance in 1873 of the choral cantata Hymnus: Heirs of the White Mountain marked Dvořák’s professional debut; with the 1878 production of the comic opera The Cunning Peasant, Dvořák celebrated his first major triumph on the coveted Czech operatic stage; and the Prague premiere in 1881 of his first widely recognized symphony, the D major, Op. 60, proved to be crucial in defining Dvořák’s role in the concert hall. These case studies reveal that Dvořák’s treatment in the Czech press varied depending on the unique traditions of these genres and their differing status within Czech musical culture. The project highlights the complex relationships and interactions among critics, audiences, and composers. In the politically-charged climate of fin-de-siècle Bohemia, Czech critics took ownership of Dvořák and enlisted his music to advance their own agendas. Dvořák, in turn, was keenly aware of and often catered to public tastes and critical expectations. Intertwining various realms of contextual inquiry, including nationalist rhetoric, contemporary critical discourses, and the musical repertories that were cultivated in the Czech lands, the dissertation draws attention to the multiple agents at play in Dvořák’s nineteenth-century Czech reception.
"Creating Tone": The Relationship Between Beethoven's Piano Sonority and Evolving Instrument Designs, 1800-1810
Keywords: Beethoven
piano
sonority
fortepiano
Erard
Streicher

The concept of “creating tone” indicates the relationship that Beethoven wanted with his main instrument, the fortepiano, and symbolizes his desire for expression when performing on the instrument. The story of Beethoven’s evolving pianistic writing unfolds in tandem with his changing instrument preferences; there is a constant feedback loop between innovations in piano construction and his piano music. This study investigates how Beethoven “created” his own tone when faced with the new Erard and Streicher instrument models in the first decade of the nineteenth century. The first chapter outlines the context of Beethoven’s involvement with contemporary instruments up to the early nineteenth century. His progressive tendencies in relation to the Stein vs. Walter actions and his interest in the English school of playing demonstrate this perspective. His eventual purchase of an Erard instrument in 1803 is an example of his desire to be on the forefront of instrument building developments in his time. The influence of Beethoven’s Erard piano on his pianistic output is assessed in chapter two by examining several compositions written during this period that reflect characteristics of French pianism and instrument building. Many of Beethoven’s pianistic innovations can be understood in the context of this new model. Pianistic devices include the use of register as a compositional dimension; vocal melodic style; textural innovations to enhance the Harmonie of the instrument, such as the tremolo effect; and the use of multiple, colourful pedals. The link between Beethoven and the instruments of the Streicher firm is the subject of the third chapter. The resultant merging of Viennese, English, and French features in piano construction led to the creation of an instrument that was reported as fully “orchestral” in sonority. Pianistic devices of this period include the return to a rapid “Viennese” touch; sustained lyricism; and, in concerto writing, scoring for the piano as an equal to the orchestra. Many of the musical elements that we embrace as characteristically Beethovenian may have their origin in these organologically-inspired pianistic effects.
Northern, Central, Diversified, Specialized: The Archaeology of Fishing Adaptations in the Gulf of Georgia (Salish Sea), British Columbia
Keywords: Coast Salish
Gulf of Georgia
Fishing
Prehistory

The Coast Salish subsistence economy has been characterized by local fishing adaptations to regional ecological variability (Mitchell 1971a.) This dissertation explores the temporal depth of these adaptations in the traditional territory of the Coast Salish, the Gulf of Georgia. Many researchers have used this, Donald Mitchell’s (1971a), model to develop theories of regional cultural development. Many of these interpretations present social complexity or social inequality – a hallmark of Northwest Coast social complexity – as having developed more or less in lock-step with the specialized fishing adaptation described among the Central Coast Salish, around the Fraser River. The temporal depth of this adaptation and the “Diversified” fishing adaptations described among the Northern and Southern Coast Salish, as well as their developmental relationship, are not well understood. In exploring this problem, this study evaluates whether or not the ecological ethnographic model is representative of the archaeology of these cultural subareas. A gap in the regional dataset which corresponds with a large portion of Mitchell’s (1971a) “Northern Diversified” fishing subarea has largely presented a previous study of this type. Recently excavated sites in traditional shíshálh territory provide artifact and archaeofaunal data that fill in this gap. These data are analyzed along with existing data from the Northern subarea and from the Central Gulf of Georgia (River and Straits Fishing subareas). The results of this study significantly broaden our understanding of prehistoric Coast Salish socioeconomic diversity, and test the assumed salmon specialization on the Fraser River and its primacy the development of regional ethnographic characteristics, especially pronounced social inequality. The results also shed light on the prehistoric importance of herring, a decreasingly overlooked resource in Northwest Coast archaeological studies, and advocate for the use of fine mesh recovery for quantifying the relative importance of fish species.
Concerto for Tar and Orchestra
Keywords: concerto
tar
cross-cultural
Persian
fusion
orchestral
musical score
thesis
Canadian

The great challenge that exists in cross-cultural composition is finding commonalities of intonation, style, formality, and instrumentation. In the case of creating a composition for Persian tar and symphony orchestra, a number of challenges emerge. The goal of this composition is to find compatible musical elements between Persian and western music. The most difficult challenge of composing in this genre is finding compatible musical modes to generate optimum intonation. For this piece, the western pitch of Bb is used to help the intonation and tonal production of the tar. My approach to style involves a sensitive application using elements of classical Persian style and formality known as dãstgãh composition. Generally, Persian music places strong emphasis on improvisation, non-repetitive scalar melodies, variation of melodic and rhythmic material, tasteful ornamentation, and creating an inspiring musical atmosphere. Often music is composed with a story, poem or song in the mind of the performer. Typically, the instrumentation is very small and intimate, consisting of a tar performer, accompanied by a musician playing a daff (a Persian frame drum much like an Irish bodhran). I have composed a work that features many of the above characteristics. The Concerto for Tar and Orchestra encompasses many salient features found in Persian classical music, while also providing symphonic orchestration that adds complimentary western musical elements. Most of the instrumentation of the work adheres to standard orchestral instrumentation. I have included some Persian hand-drums to the orchestration (a tombak and a dohol) to play alongside standard symphonic percussion to add a more cross-cultural quality to the orchestration. The concerto also owes its inspiration to the story “Umar and the Harpist”, which is found in Jellaludin Rumi’s revered, masterful literary work entitled the Masnavi. I used the imagery found in this story to generate much of the dramatic contrast contained in the concerto. In the end, a composition has emerged which brings two distinct classical music traditions together in an effective cross-cultural form of expression.