VictorJuiz/thesis huggingface dataset:
Mathematical problems relating to the fabrication of organic photovoltaic devices
Keywords: evaporating films
confined phase separation
multiphase flow
topological transformation
Marangoni instability
WKB approximation
multiple scales
sharp-interface asymptotics

The photoactive component of a polymeric organic solar cell can be produced by drying a mixture consisting of a volatile solvent and non-volatile polymers. As the solvent evaporates, the polymers demix and self-assemble into microscale structures, the morphology of which plays a pivotal role in determining the efficiency of the resulting device. Thus, a detailed understanding of the physical mechanisms that drive and influence structure formation in evaporating solvent-polymer mixtures is of high scientific and industrial value.
This thesis explores several problems that aim to produce novel insights into the dynamics of evaporating solvent-polymer mixtures. First, the role of compositional Marangoni instabilities in slowly evaporating binary mixtures is studied using the framework of linear stability theory. The analysis is non-trivial because evaporative mass loss naturally leads to a time-dependent base state. In the limit of slow evaporation compared to diffusion, a separation of time scales emerges in the linear stability problem, allowing asymptotic methods to be applied. In particular, an asymptotic solution to linear stability problems that have slowly evolving base states is derived. Using this solution, regions of parameter space where an oscillatory instability occurs are identified and used to formulate appropriate conditions for observing this phenomenon in future experiments.
The second topic of this thesis is the use of multiphase fluid models to study the dynamics of evaporating solvent-polymer mixtures. A two-phase model is used to assess the role of compositional buoyancy and to examine the formation of a polymer-rich skin at the free surface. Then, a three-phase model is used to conduct a preliminary investigation of the link between evaporation and phase separation.
Finally, this thesis explores the dynamics of a binary mixture that is confined between two horizontal walls using a diffusive phase-field model and its sharp-interface and thin-film approximations. We first determine the conditions under which a homogeneous mixture undergoes phase separation to form a metastable bilayer. We then present a novel mechanism for generating a repeating lateral sequence of alternating A-rich and B-rich domains from this bilayer.
Family size and educational consequences in the UK
Keywords: intergenerational relationships
households
children and youth
social mobility
statistics (social sciences)
sociology
families

This thesis investigates in what ways the family matters for educational outcomes. Six research questions are answered. First, is family size associated with familial resources? Second, is having a large family associated with lower levels of objective and subjective educational outcomes and has this changed over the 20th century? Third, is there evidence of an association between family size and emotional health and life perspectives of young people? Fourth, is there any evidence of an association between family size and the degree of confidence and sociability? Fifth, do parenting strategies vary by family size? Sixth, is there evidence if a causal relationship between family size and educational outcomes?
The British Household Panel Survey, the Longitudinal Survey of Young People in England and the ONS Longitudinal Study are used to answer these questions.
The key findings from the observational studies are as follows. First, as family size increases there is a reduction in familial resources. Second, as a result of resource dilution there is a reduction in the highest qualification attained; this finding is robust to alternative measures of educational outcomes. Third, there is a positive relationship between family size and reporting poor emotional health and external locus of control. Fourth, there is some evidence that the manner in which the young person socialises varies by family size. Fifth, parenting strategies vary by family size; these strategies are positively associated with GCSE achievement and ameliorate the negative family size association. Sixth, testing the resource dilution model using twins as an exogenous increase in family size found that there is weak evidence of a causal relationship between family size and educational outcomes.
This thesis addresses the influence of the family on inequalities in education. The findings have important implications for future research on this topic.
Essays in corporate restructuring, reputation and law
Keywords: Reputation
Finance
Law

This dissertation consists of three essays which examine topics at the intersection of law and finance.
The first essay investigates the role of regulatory sanctions and reputational damage in financial markets. We study the impact of the announcement of enforcement of financial and securities regulation by the UK’s financial regulators on the market price of penalized firms. We find that reputational sanctions are very real: their stock price impact is on average almost 9 times larger than the financial penalties imposed. Furthermore, reputational losses are confined to misconduct that directly affects parties who trade with the firm (such as customers and investors).
In the second essay we analyze the costs and benefits associated with secured creditor control in bankruptcy. We do it by studying the highly contested practice of UK pre-packs, where a deal to sell the business is agreed before publicly entering into bankruptcy. Contrary to widespread criticism that this procedure leads to collusion, we find no evidence of exploitation of conflict of interests and we find that it preserves the value of the business and maximizes recovery in circumstances in which a public announcement of bankruptcy would destroy value. In small businesses where secured creditors are concentrated the benefits of their control seem to outweigh the costs.
Finally, in the last essay we examine whether mandatory shareholder voting prevents wealth destruction in corporate acquisitions. We study the UK setting where all large transactions must have shareholder approval. We observe that such Class 1 transactions always get consent. Nevertheless, there is a striking difference between the performance of acquirers between Class 1 and other transactions. The finding is most pronounced for transactions in a narrow neighbourhood of the size threshold, and is robust to a large set of controls for confounding effects.
Political culture and urban space in early Tudor London
Keywords: urban environment
cities and towns
political communication
early modern
civic government

This thesis examines political culture in London, 1500–1550, by looking at different forms of political communication between the civic government and the city’s inhabitants, and at how these acts were situated within the urban environment. Based on the records of the civic government, the body of the work is divided into two halves addressing those acts conducted by the authorities – proclamations, processions, public punishments – and those directed towards the civic government by others, such as petitions, libels, and seditious talk. The study of these acts reveals two important things: first, that they were not only pragmatic attempts to communicate information, but also performances designed either to construct or contest particular images of authority; secondly, that these performances were spatially structured and that the urban environment was an integral aspect of the city’s political culture. It is then demonstrated that, just as political communication was inherently performative and spatial, so the urban environment was itself a medium of political communication.
These observations highlight the importance of political communication to an understanding of the city’s political culture as depicted in the historiography of early modern London. At the same time, recent scholarship on the later sixteenth and early seventeenth centuries has identified an increasingly distinctive culture in towns typified by attitudes to political authority as communal and contingent, and to social identity as performative and self-fashioned. In London in particular, historians have pointed to a radical transformation in the city’s political culture in reaction to dramatic urban growth after 1550. The spatial aspect of this, however, has been neglected. It is argued here that the inherently political nature of urban space and its communicative potential, already in existence, was integral to changing urban values and part of what made rapid change in London after 1550 a politically traumatic and transformative process.
The function of NOD2 in antigen presenting cells
Keywords: LCP1
proteomics
Crohn's disease
NOD2
SHP1
phosphoproteomics
autophagy
DAPK1

Crohn’s disease (CD), a chronic inflammatory condition of the gut affecting 1:1000 of western populations, is thought to arise from a dysregulated immune response in a genetically susceptible individual. Polymorphisms in the ligand recognition domain of an intracellular pattern recognition receptor (PRR), NOD2, remain the strongest genetic risk factor for the development of CD. NOD2 directs autophagy in human DCs to facilitate bacterial destruction and antigen presentation; the CD-variant-NOD2 shows defects in this pathway. Recent work in the laboratory has demonstrated NOD2 signals to control expression induction of microRNA-29, which is impaired in cells from CD patients expressing CD NOD2-variants, and among other immunoregulatory effects, microRNA-29 suppresses IL-12p40/IL-23. Thus NOD2 directs key anti-microbe and immunoregulatory functions whose breakdown in the presence of CD-variant-NOD2 could act as a trigger for inflammation in this disease.
In comparison with other PRRs, relatively little is understood of the hardwiring of NOD2 signalling, the mechanism of NOD2-mediated autophagy induction, the means by which NOD2 recruits a signalling platform within the cytosol and the mechanism of synergy with other PRRs and the inflammasome. In this work I used quantitative proteomics to map the NOD2 signalling cascade and its cross-talk with TLR2, demonstrating novel mediators: LCP1, a plastin, reduced phagocytosis of bacteria but did not alter bacterial killing, and aided control of the release of MCP1 and may be involved in IL-12p40 release. SHP1, a phospho-tyrosine phosphatase, is required for the propagation of signalling cascades via p38, p44/42 MAPK and NF-κB. It controls release of MIP1β and IL-12p40. HMGB1, an alarmin, is dephosphorylated on NOD2 stimulation and would result in changes to cellular location of HMGB1. Lastly, DAPK1, a serine/threonine kinase, is associated with HLA-DM loading compartment on NOD2 triggering, but does not alter CLIP levels on the surface of the cells. Thus, defining the hard wiring of NOD2 signalling in healthy donors, in comparison with CD donors expressing variant NOD2, is important to define targets amenable to drug design within this pathway.
The role of DOCK8 in the maintenance of  CD8+ T cell memory and invariant NKT cells
Keywords: memory CD8 T cells
DOCK8
GEF
NKT cells

The use of genome wide ENU mutagenesis screening has uncovered vast numbers of novel genes involved in the control of the immune system. This thesis describes the characterization of a novel mutant, Captain Morgan (CPM), originally identified in an immunization screen designed to evaluate both the initial antibody response to antigen and the ability to sustain antibody production. Mapping of this mutant lead to the identification of a single base pair mutation in a novel guanine nucleotide exchange factor, dedicator of cytokinesis 8 (DOCK8). The mutation was found to result in altered gene splicing of the DOCK8 protein leading to the truncation of the protein and loss of catalytic function.
The importance of understanding the role of DOCK8 in host immunity has been recently underlined by the discovery that cohorts of patients suffering from autosomal recessive forms of hyper-IgE syndrome have loss-of-function or deletions in this novel guanine nucleotide exchange factor. Disease in these patients is characterised by recurrent viral and bacterial infections mainly of the skin and lungs, with reduced levels of peripheral CD4+ and CD8+ T cells in the blood of patients. Patients also have high levels of IgE and eosinophilia in the blood and are highly atopic with increased prevalence of allergic diseases including asthma.
Loss of DOCK8 function results in a number of phenotypes in CPM mice, which may help understand the immunodeficiency syndrome experienced by DOCK8 deficient patients. CPM mice, like DOCK8 deficient patients, are lymphopenic with losses of both CD4+ and CD8+ T cells in the blood and secondary lymphoid organs. Challenge of CPM mice with modified vaccina virus (MVA) and influenza strain X31 demonstrated normal primary anti-viral responses. However, similar to the loss of germinal centre B cells previously described in these mice, memory T cell responses were diminished, which may explain the susceptibility of DOCK8 deficient patients to recurrent infections. In addition to the loss of peripheral T cells, rare populations of lymphocytes such as invariant natural killer T cells (iNKT) were also reduced in the liver and thymus. Due to their roles in bacterial and viral responses and cancer immunosurveillance it is expected that loss of these cells will contribute to disease severity.
Together these findings illustrate the importance of the ENU mutagenesis model for generating new mutants, which can enhance our understanding of mammalian genes and create disease models of human disease. Further characterization of DOCK8 deficiency and the molecular mechanisms of DOCK8 function will have important implications for disease diagnosis and ongoing treatment for patients.
Nudging young ESL writers: Engaging linguistic assistance and peer interaction in L2 narrative writing at the upper primary school level in Brunei Darussalam
Keywords: young learners
peer interaction
linguistic assistance
second language writing

Motivated primarily by a cognitive approach, with consideration of interactional processes from a sociocultural perspective, the present study examined the use of linguistic assistance and peer interaction to facilitate second language (L2) writing of young ESL learners. A total of 257 Year 5 children (age 10) from twelve intact classes (from six different schools) took part in this eight-week intervention-based study. Using a quasi-experimental design, the classes were randomly assigned to one of three treatment groups or the control group. Pretests, interim tests, immediate posttests and delayed posttests were administered. As the study concerned both the processes and products of L2 development, peer interaction and children's written production were taken as the two primary sources of data for this study.
For the written production, four criteria were used to rate learners’ writings: Quality of ideas, Story shape and structure, Vocabulary and spelling and Implicit grammar. Partial correlation was employed to examine if there were any statistical relationships between treatment and learners’ written performance while controlling for prior attainment. Results show that the provision of enhanced and basic linguistic assistance may have a positive influence on only certain aspects of L2 writing, while opportunities for peer interaction does not appear to have an impact on learners’ L2 performance.
For peer interaction, a subset of 60 learners were selected from the two treatment groups which received basic and enhanced linguistic assistance, to compare their dialogic performance. Based on quantitative analyses of their recorded interactions, the findings suggest that the provision of varying degrees of linguistic assistance may affect, not the content of peer discussions, but how peer assistance is given during task. The results also show that through the provision of linguistic assistance, peer interaction mediates the participants’ performance on Quality of ideas, Story shape and structure and Implicit grammar in their subsequent individual writing.
Essays on the credit channel of monetary transmission
Keywords: policy identification
finance
deregulation
financial intermediation
economics
money and banking

This thesis is a collection of three essays with contributions to the empirical literature on banking and the lending channel of monetary policy. The first essay on monetary policy identification addresses the endogeneity of the monetary policy measure employed in most bank level studies of the lending channel. It shows how an identified, exogenous measure of policy evokes different lending dynamics in U.S. commercial banks compared to the standard endogenous measure of monetary policy. The second essay empirically assesses the impact of financial deregulation on the lending channel in the U.S. In particular, it analyses how the gradual phasing out of deposit rate ceilings commonly known as Regulation Q significantly altered bank level frictions as well as the transmission of monetary policy to individual bank lending. While the first two essays consider U.S. bank level data, the third essay analyses individual bank level lending responses in the euro area. Its contribution lies in the construction of a range of exogenous and unanticipated monetary policy shocks as well as in the introduction of a financial conditions index into standard lending regressions. It finds that the lending responses of individual banks to monetary policy do not support the existence of a separate lending channel in the euro area. Further, equilibrium lending responses to policy as measured by a range of policy shocks is non-linear in financial conditions. Specifically, financial conditions as measured by the relative performance of a broad index of euro area banking stocks to the overall euro area stock market reverse the impact of monetary policy on lending.
Judging without scales
Keywords: law
philosophy

This thesis is about the nature of value incommensurability and its significance for judicial reasoning. It argues that there can be incommensurable values and that this incommensurability can have significant implications for judicial reasoning. I argue that incommensurability gives rise to a range of reasonableness, within which it is reasonable but in a sense also arbitrary to decide either way, and that this range is wider than is suggested by the notion that some options are roughly equal, because even a large improvement to one option may not make it the uniquely correct option. The thesis goes on to consider the effect that the authority of law can have on choices between incommensurable options. Although I argue that the authority of law can sometimes provide a conclusive reason to choose one of two incommensurable options, I also argue that it has limits and may not do so in every case of incommensurability. Moreover, the introduction of an authoritative directive may even give rise to incommensurable options where none previously existed.
The thesis then draws out the implications of these claims, first, for human-rights adjudication—where my claim is that ‘balancing’ is appropriate both in the specification of rights and in assessing the justification for their infringement, provided we acknowledge the limits of balancing in cases of incommensurability—and, secondly, for adjudication involving common law reasoning and statutory interpretation. Finally, I suggest that we can distinguish between different ideals of the rule of law, and that the arbitrariness of judicial decisions involving incommensurable options has different implications for those different ideals. The arbitrariness involved in choosing between undefeated reasons may be necessary contrary to one ideal of the rule of law, understood as the rule of authority, but not contrary to an ideal of the rule of law understood as the rule of reason.
Prophets reading prophecy: the interpretation of the Book of Revelation in the writings of Richard Brothers, Joanna Southcott and William Blake
Keywords: Biblical Interpretation
William Blake
prophecy
Joanna Southcott
Richard Brothers
Book of Revelation

This thesis examines the use and interpretation of Revelation in the writings of the contemporary prophets Richard Brothers, Joanna Southcott and William Blake. Contributing to an emerging scholarly interest in the reception of biblical texts within marginalised interpretative traditions, the thesis offers a detailed exploration of how Revelation is incorporated into these authors' prophetic texts, and how it informs the identity of readers who see their activities as bringing about the fulfilment of the text's visions on the historical plane. This aim is achieved by engaging with extant comparative studies of Brothers, Southcott and Blake within historical and literary studies; a comparison with similar contemporary prophetic figures and the contribution of Revelation to their prophetic self-understandings; and contextualising these figures against contemporary constructions of Revelation as a prophetic text, and the recognition of the poetic nature of biblical prophecy in the eighteenth century. In particular, the thesis advocates for the continued exploration of "emic" approaches to these figures, a process started by members of Oxford's Prophecy Project. The thesis thus argues that "prophecy", rather than "millenarianism," is the most appropriate way of characterising these authors' scriptural engagement, and explores how prophecy is understood in their writings to delineate commonalities in their understanding of the prophet's role. Finally, it surveys how Revelation is interpreted within the respective works of the writers who are the focus of this thesis. The conclusion offers a hermeneutical reflection on the relationship between the prophetic interpreter and the texts they engage with. It suggests that the reader who claims to be "inspired" faces a tension between offering an interpretation of the authoritative text, and claiming an equivalent level of authority for their own works.
The thesis makes three contributions to existing scholarly debates. Firstly, it demonstrates that attention to these three authors' interpretations of Revelation shows how attention to neglected voices illuminates the history of interpretation of this biblical book. Secondly, it justifies comparing these three authors under the framework of "prophecy", rather than the anachronistic terminology of "millenarianism." Thirdly, it explores their readings of Revelation to shed light on how interpretation of a scriptural text such as Revelation is key to the evolution of prophetic vocation; how Revelation’s images are developed and transformed in their own prophetic texts; and finally, their sensitivity to hermeneutical questions raised by Revelation’s relationship to other biblical texts and the problems posed by its eschatology.