VictorJuiz/thesis huggingface dataset:
An Evaluation of Maimonides' Enumeration of the 613 Commandments, with Special Emphasis on the Positive Commandments
Keywords: Maimonides
Commandments
Legal Philosophy

The TaRYaG count, that is the traditional enumeration of the 613 commandments contained in the five Mosaic books (Torah), has gained a prominent place in Judaism. The count is based on a dictum found in the Babylonian Talmud and attributed to R. Simlai, a Palestinian rabbi of the late third century. No one did more to see this count achieve the importance it has than Moses Maimonides, the prominent 12th-century Jewish philosopher and perhaps the most important post-talmudic jurist of all times. M. offered an impressive methodology, made up of rules of individuation, identification and interpretation - in all, fourteen rules - to support his proposed enumerative scheme and used it to critique all previous such attempts. By his own account, Maimonides undertook this project with the sole aim to provide a comprehensive outline for his upcoming Code of Jewish Law. This thesis demonstrates the enormous difficulties inherent in such a project - difficulties that could not have passed unnoticed by such an accomplished author - and seeks to uncover any other reason or reasons that may have prompted him to adopt such a constraining count. The thesis concludes by speculating that Maimonides may have found it convenient to use the TaRYaG scheme in order to introduce into the list of commandments the beliefs in the existence of God and in His unity - beliefs that had previously not been considered commandments. An ancillary product of the dissertation is the discovery that many of the commandment designations proposed in the enumerative scheme are abandoned in the Halakhot, a discovery that was noted, albeit only partially, by less than a handful of scholars over the past eight hundred and fifty years. The dissertation examines the proposed solutions and rejects them on a number of counts. A systematic analysis of these occurrences suggests a more consistent solution and reveals an aspect of Maimonides that has not been sufficiently appreciated, Maimonides the exegete and legal philosopher. The agenda-oriented research also examines some of the important innovations contained in M’s list of positive commandments, the hermeneutics behind them and the politico-philosophical ideas that may have informed them.
Fiddle Grooves: Identity, Representation, and the Sound of Cape Breton Fiddle Music in Popular Culture
Keywords: 0326
0334

This dissertation investigates Cape Breton fiddle music from a popular culture perspective. It introduces a conception of musical groove comprising two interrelated components: a social component wherein individual musical actors retain their own identities and relationships with the music while also uniting collectively in their response to the music, and a sonic component consisting of an acoustical repeating of a rhythmic idea that forms the metrical underpinning for a piece of groove music. Each of these two components is informed and mediated by the other. Cape Breton fiddle music is considered here as a form of groove-based popular music, similar to other groove musics. The two dimensions of the groove are analyzed in turn, revealing aspects of social identity, political and commercial representation, and processes of intercultural syncretism that have resulted in the evolution of the music within the pop culture mainstream. The dissertation is divided into two large sections. The first section concerns the social component of the Cape Breton fiddle groove, considering aspects of cultural representation, social identity, globalization and perceived external threats, and intersections with popular culture. The second section examines the sound of Cape Breton fiddle music as a form of groove-based music by first proposing a general model for the analysis of groove-based musics, and then applying the model to the Cape Breton fiddle context. The social and sonic components of Cape Breton fiddle grooves are treated as mutually reinforcing components of the same cultural product. Explorations of social identity and cultural representation of Cape Breton fiddle music determine those aspects of the sonic dimension of the music with the most social salience. In turn, analyses of the sound of Cape Breton fiddle grooves influence the understanding of the contemporary and historical socio-cultural community. Cape Breton fiddle music is therefore used here as a case study for combining the powerful modes of inquiry from the disciplines of music theory and ethnomusicology, leading to a richer and more nuanced understanding of musical traditions and cultures in general.
Percy Grainger: Sketch of a New Aesthetic of Folk Music
Keywords: Percy Grainger
English Folk Song, Aesthetics

Percy Grainger collected English folk song only for a short period between 1905 and 1909 as part of the revival of interest in all things English among antiquarians, folklorists, and nationalists. Grainger’s publication of his transcriptions and analysis in the Journal of the Folk Song Society in 1908 is considered one of the most insightful and groundbreaking examinations of English folk song of its time, far removed from the dilettante activities of many other collectors. His article was, however, harshly criticized by the Editorial Committee of the Journal, and Grainger subsequently never again published any significant transcriptions of English folk music. Grainger’s English folk song transcriptions have received their fair share of attention from ethnomusicologists. Thus far, however, no one has examined the connections between this aspect of his musical activities and his modernist philosophy of music. I contend that Grainger’s article contains the seeds of what would eventually become his mature, though never fully realized, musical aesthetic, and that it was this aesthetic that allowed him to examine English folk song in a manner never before imagined by other collectors. This dissertation follows the thread of his aesthetic throughout his numerous musical interests in order to demonstrate the potency of his philosophy as manifest in his examination of folk song in the Journal. To this end, I bring to bear a wide range of critical methodologies, including those of ethnomusicology, aesthetics, and critical theory. Grainger never spelled out with any clarity the fundamental tenets of his aesthetic, but I believe that such an aesthetic can be reconstructed through a broad examination of his writings and his music. Grainger shares his role in this dissertation with many other characters including Benjamin Britten, Evald Tang Kristensen, Cecil Sharp, Bela Bartok, Ferruccio Busoni, and even Jacques Derrida, often even ceding his place in the spotlight to them. This is, however, a crucial occurrence, for as my examination demonstrates, this fully realized version of his aesthetic means that Grainger emerges as a far more important and revolutionary thinker in the history of music than he has thus far been considered.
The English Inheritance of Biblical Verse
Keywords: Medieval Latin
Poetry

“The English Inheritance of Biblical Verse” explores the transmission of late antique Latin biblical poetry to England and the subsequent development of the genre in the vernacular. This study offers close readings of the most important contributions to a genre that produced more than twenty major compositions between AD 400 and 1500. For over a millennium, this literature effectively represented the Bible in popular form, yet this is the first study to explore the stylistic and thematic affinities between the Latin and English traditions. Chapter 1 provides an introduction to ‘biblical verse,’ defines the term and offers a broad outline of the genre, including a summary of general stylistic features and critical trends. The first chapter also provides an overview of the subject matter in each of the following chapters. Chapter 2 discusses the Latin beginnings of the genre in the fourth century, beginning with the poetry of Juvencus, whose stylistic choices regarding the appropriation of classical literature establish many of the generic norms for later poets. Among them is Cyprianus, who reflects the Juvencan model in his Heptateuch, while Prudentius, though not a biblical poet per se, anticipates a movement toward stylistic freedom in later versifications of the Bible. Chapter 3 examines the growing stylistic freedom among biblical versifications at the end of late antiquity. Sedulius, Avitus and Arator break the silence imposed by epic conventions of detachment and begin to comment on the underlying significance of biblical episodes such as the crossing of the Red Sea at length. Biblical exegesis and figural allusions to Christ abound in the poetry of this period. Chapter 4 shifts the focus to Anglo-Saxon England and the study of Juvencus, Sedulius and Arator in the monastic schools of the time. Many Anglo-Latin writers, especially Aldhelm, Bede and Alcuin, borrow heavily from the style of late antique biblical verse. My purpose here is to deepen our understanding of the specific ways in which this is the case. Chapter 5 makes another transition, to Old English biblical poetry. My goal here is to explore the ways in which the Latin and vernacular traditions overlap. My approach is mainly stylistic, and I focus in particular on the biblical verse of the Junius manuscript, containaing Genesis A/B, Exodus, Daniel and Christ and Satan. Chapter 6 offers some conclusions about the variety of functions and audiences of this literature. I also suggest what work remains to be done and how knowledge of the Latin tradition informs our understanding of the literature of the Anglo-Saxon period. My goal, therefore, is to examine various ways in which poets of different eras versify the Bible by considering what is omitted from, elaborated upon and unique to a given period or author. Ultimately, I aim to show that Latin and Old English biblical verse have more in common that not and that knowledge of the former enriches understanding of the latter.
The Sexualized and Gendered Tortures of Virgin Martyrs in Medieval English Literature
Keywords: Virgin Martyrs
Sexualized Torture
Medieval English Literature
Hagiography
Saints

This work examines the literary English traditions of four Virgin Martyrs: Agatha of Catania, Agnes of Rome, Juliana of Nicomedia, and Katherine of Alexandria. The primary focus surrounds the narratological developments and alterations of these women’s sex-specific or -emphasized tortures. In addition to torments, other details, which may not initially appear sex-specific in nature, are also considered. As recent scholarship has shown, Virgin Martyrs’ lives tend to conform to a relatively standardized core narrative by the later Middle Ages. This study considers to what extent the lives of these four saints actually conform and to what extent they retain individualism despite this homogenizing trend. An analysis of each narrative’s progression from early Latin sources, when available, through fifteenth-century English texts, which supplements the current scholarly trend of examining Virgin Martyrs as a collective group, is also provided. The tracing of these legends’ sex-specific characteristics allows for clear identification of similarities and deviations within various sources. Five appendices, each including an analytical table, are included to aid in the visualization of this progression. The tables, which allow for quick and easy identification of variations through chronologically listed sources, demonstrate this process in a concise and user-friendly manner and should be utilized alongside examinations of these legends as presented in each of the central chapters. The first chapter, on Agatha, addresses her breast amputation and its symbolic implications for femininity and motherhood, as well as the argument that Virgin Martyrs ‘Become Male’ during their passiones. The second chapter, on Agnes, explores her traditionally eroticized relationship with Christ, the motif of concealment, and Virgin Martyrs’ conventional brothel experience. The third chapter, on Juliana, focuses upon the Warrior Virgin Martyr tradition, her physical and spiritual struggle with the devil, and the tradition of familial rejection. The final chapter, on Katherine, considers her position as supreme Bride, her limited physical trials, and her relationship with the Blessed Virgin. The final appendix contains a comparative chart of Virgin Martyr legends within the Legenda aurea, which indicates the frequency of motifs and plot devices in these lives.
Cell- and Cell-based Gene Therapy for Experimental Acute Lung Injury and Sepsis
Keywords: cell therapy
cell-based gene therapy
acute lung injury
Acute Respiratory Distress Syndrome
mesenchymal stromal (stem) cells
angiopoietin
inflammation
sepsis

The acute respiratory distress syndrome (ARDS) and its less severe form, acute lung injury (ALI), are among the leading causes of morbidity and mortality in critically ill patients. Commonly induced by conditions associated with severe pulmonary inflammation, ALI results in disruption of the lung alveolar-capillary membrane barrier and resultant pulmonary edema associated with a proteinaceous alveolar exudate. Sepsis is another frequent and often fatal clinical condition for patients in the intensive care unit. It is characterized by a combination of infection and systemic inflammatory response syndrome (SIRS). Current effective treatment strategies for both ALI/ARDS and sepsis are lacking. We first examined the potential therapeutic role of mesenchymal stromal cells (MSCs) alone or together with the vasculoprotective factor, angiopoietin-1 (ANGPT1), for treatment of experimental ALI in mice. MSCs significantly reduced LPS (lipopolysaccharide)-induced pulmonary inflammation, as reflected by cell counts in bronchoalveolar lavage (BAL) fluid and pro-inflammatory cytokine levels in both BAL fluid and lung parenchymal homogenates. More importantly, administration of MSCs transfected with human ANGPT1 plasmid (MSCs-pANGPT1) completely reversed LPS-induced permeability in the lung (i.e., ALI). A follow-up study showed that MSCs remained effective in rescuing mice with LPS-induced ALI; however, the additional benefit from ANGPT1 was no longer observed. To further evaluate MSC-based therapy in a more clinically relevant model of acute injury, the cecal-ligation-and-puncture (CLP) model for sepsis was employed. Our results demonstrated that MSCs can reduce both systemic and pulmonary inflammation, as well as renal and liver dysfunction/injury, as reflected by plasma urea and bilirubin levels, in septic mice. Most notably, MSCs reduced sepsis-associated mortality from 45% to 24%. Our data demonstrate the feasibility and effectiveness of MSC- and MSC-based gene therapy for experimental ALI and sepsis, and provide the basis for the development of an innovative approach for the prevention and treatment of clinical ALI/ARDS and sepsis.
Juvenile GM2 Gangliosidosis: A Model for Investigation of Small-molecule Therapies for Lysosomal Storage Diseases
Keywords: pediatrics
biochemical genetics

Juvenile GM2 gangliosidosis (jGM2) is a group of inherited neurodegenerative diseases caused by deficiency of lysosomal β-hexosaminidase A (Hex A) resulting in GM2 ganglioside accumulation in brain. Like many other lysosomal storage diseases (LSDs), no specific treatment currently exists. In order to establish clinical outcomes for the investigation of potential therapies for jGM2, I collected comprehensive information on the natural history of the condition by studying retrospective and prospectively a cohort of 21 patients with the disease, and reviewing previously published reports of 134 patients. Several symptoms at disease onset, symptom latencies, and the survival curve were described. Genotype-phenotype correlations and neuroradiological findings were also studied. Based on pre-clinical results in animal models, we studied substrate reduction therapy (SRT), with miglustat, in a phase I/II clinical trial to assess its pharmacokinetics (PK), safety, tolerability in infantile and jGM2. Miglustat showed a PK profile similar to the one found in adult patients. The drug was found to be safe and well-tolerated in patients with jGM2, with diarrhea and weight loss being the most common drug-related adverse events. The analysis of efficacy showed that SRT was unable to arrest the full neurological progression of the condition; however, relative stabilization of cognitive function was noted, which was consistent with brain MRI findings. Because of the limited efficacy obtained with SRT, enzyme-enhancement therapy was considered to be an attractive alternative therapy for the late onset forms of GM2 gangliosidosis. Screening of a FDA-approved library of approved therapeutic compounds resulted in the identification of pyrimethamine, as a potential pharmacological chaperone for mutant forms of Hex A. Relative enhancements of enzyme activity and protein levels were observed in patient cells treated with therapeutic concentrations of drug. Applying the same principles, ambroxol was identified as a potential PC for mutant glucocerebrosidase (GCC), the lysosomal enzyme that when deficient causes Gaucher disease (GD). Significant increases of residual mutant GCC were observed in cultured patients cells with type 1 GD. In conclusion, principles developed in the course of studies on jGM2 were shown to be useful for the investigation of novel small-molecule therapies for LSDs, associated with significant neurodegeneration.
One-hit Stochastic Decline in a Mechanochemical Model of Cytoskeleton-induced Neuron Death
Keywords: neuron
neurodegeneration
programmed cell death
cell death
one-hit model
mutant steady state
cytoskeleton
cell mechanics
metastability
stochastic kinetics
contagious apoptosis
death factor diffusion

Much experimental evidence shows that the cytoskeleton is a downstream target and effector during cell death in numerous neurodegenerative diseases, including Parkinson's, Huntington's, and Alzheimer's diseases. However, recent evidence indicates that cytoskeletal dysfunction can also trigger neuronal death, by mechanisms as yet poorly understood. We studied a mathematical model of cytoskeleton-induced neuron death in which assembly control of the neuronal cytoskeleton interacts with both cellular stress levels and cytosolic free radical concentrations to trigger neurodegeneration. This trigger mechanism is further modulated by the presence of cell interactions in the form of a diffusible toxic factor released by dying neurons. We found that, consistent with empirical observations, the model produces one-hit exponential and sigmoid patterns of cell dropout. In all cases, cell dropout is exponential-tailed and described accurately by a gamma distribution. The transition between exponential and sigmoidal is gradual, and determined by a synergetic interaction between the magnitude of fluctuations in cytoskeleton assembly control and by the degree of cell coupling. We concluded that a single mechanism involving neuron interactions and fluctuations in cytoskeleton assembly control is compatible with the experimentally observed range of neuronal attrition kinetics. We also studied the transit of neurons through states intermediate between initial viability and cell death. We found that the stochastic flow of neuron fate, from viability to cell death, self-organizes into two distinct temporal phases. There is a rapid relaxation of the initial neuron population to a more disordered phase that is long-lived, or metastable, with respect to the time scales of change in single cells. Strikingly, cellular egress from this metastable phase follows the one-hit kinetic pattern of exponential decline now established as a principal hallmark of cell death in neurodegenerative disorders. Intermediate state metastability may therefore be an important element in the systems biology of one-hit neurodegeneration. Further, we studied the full spatiotemporal dynamics of death factor pulses released from dying neurons to emphasize the effects of the cell-to-cell coupling strength on neuron death rates. The rate of neuron cell loss monotonically increased with increased diffusion-dependent intercellular communication. Death factor diffusion effects may therefore be important moderators of one-hit neurodegeneration.
Subcortical Ischemic Vasculopathy In Alzheimer's Disease: Brain-behaviour Relationships
Keywords: Alzheimer's Disease
Magnetic Resonance Imaging

The presence of white matter hyperintensities (WMH) and silent infarcts on magnetic resonance imaging is a common finding in elderly individuals. This subcortical ischemic vasculopathy is associated with age and cerebrovascular risk factors and can increase the risk of dementia, yet the contribution of subcortical vascular disease to the clinical profile and progression of Alzheimer’s disease patients is still relatively poorly understood. This study assessed the presence, severity and progression of WMH and lacunar infarcts and studied their relationship with measures of brain function and cognition in 64 patients with Alzheimer’s disease. Both a visual rating scale and volumetric tissue segmentation analysis were used to evaluate brain-behaviour relationships of WMH seen on T2-weighted and Proton Density MRI scans. In addition to describing the topographical distribution of WMH and lacunes, and examining sex differences, the volume and location of WMH were correlated with executive function, frontal lobe perfusion, and medial temporal lobe atrophy. The results confirm and extend previous findings suggesting that WMH are located primarily in the frontal and parietal regions and are associated with mild decline in tasks of executive function. WMH severity was not associated with a decrease in frontal lobe perfusion as measured by Single Photon Emission Computed Tomography. The investigation of different WMH subtypes revealed that lacunar infarcts were found most often within deep WMH. At one year follow-up, progression was seen in deep WMH, specifically in the frontal lobe and in lacunes found within the periventricular regions. Furthermore, progression in WMH was associated with a decline in cognition. Taken together, these studies indicate the utility of measuring WMH by subtype (periventricular and deep WMH and lacunes) in understanding progression patterns and brain-behavior relationships. Since, subcortical ischemic vasculopathy may be potentially preventable; this study underlines the need to study interventions that address risk factors for the development of small vessel cerebrovascular disease, which may be helpful in preventing disability in the elderly.