VictorJuiz/thesis huggingface dataset:
Becoming Romano-British: The landscape of the late prehistoric and Romano-British periods in the Vale of the White Horse.
Keywords: Iron Age
Settlement Patterns
Thames Valley
Vale of the White Horse
Landscape archaeology
Roman Period

This thesis investigates the rural landscape of the Vale of the White Horse in the late Iron Age and the Roman period. Its three aims are to place the Roman temple, amphitheatre and cemetery at Marcham / Frilford within the context of the wider rural landscape, to document the nature of the Romano-British social and economic structure and its relationship to earlier Iron Age systems, and to compare the rural community of the Vale with other communities in the upper Thames Valley.
The first aim is addressed by analysing the archaeological data for the neighbourhood of the religious complex at Marcham / Frilford, integrating recent geophysical survey and commercial archaeological evaluations. It is considered whether the site's function was restricted to an extensive religious complex, or whether it can be classed as a small town. Although there is no evidence for urbanism in terms of densely packed buildings, market activities are possible. It is suggested that the cemetery might be a 'managed cemetery'.
The second and third aims are addressed by presenting and evaluating the archaeological evidence for the use of the landscape. The development of the Iron Age into the Romano-British landscape is seen through changes in settlement density, structure and form, buildings such as villas, ditched field systems, communication via roads and trackways, increasing population and agricultural intensification.
Variations in settlement forms in the Vale of the White Horse are considered within the wider context of settlement in the upper Thames Valley. The Iron Age landscape of the Vale appears similar to that of the gravel terraces north of the river Thames. In the Roman period it differs from the gravel terraces to the north by becoming a region of villas and local centres, which suggests differences in landholding and in social and economic structures. In addition, the late Iron Age and Romano-British settlement in the Vale of the White Horse is compared with other regional studies.
The compatibility between a theologically relevant libertarian notion of freewill and contemporary neuroscience research
Keywords: philosophy of action
theology
emergence
voluntary
free will defence
neuroscience
free will
responsibility
choice

The notion that we are voluntary agents who exercise power to choose and, in doing so, determine some of what happens in the world has been an important notion in certain theological accounts concerning our relationship with God (e.g. 'the freewill defence' for God's goodness and omnipotence in light of moral evil and accounts of human moral responsibility in relation to God). However, it has been claimed that the physicalism supported by contemporary neuroscience research calls into question human voluntary agency and, with it, human power to choose. Emergentist (or non-reductive physicalist) accounts of psychological phenomena have been presented as a way of reconciling the physicalism supported by contemporary neuroscience and the theologically important notion of human power to choose. But there are several issues that remain for the plausibility of the required kind of emergentist account; namely - Does recent neuroscience research show that voluntary agency is an illusion? and Is there evidence for neurophysiological causes which, along with neurophysiological conditions, determine all we do? In this dissertation I set out to address these issues and, in doing so, present an account of voluntary agency as power to choose in the state of being aware of alternatives. I argue that this account allows for the notion that human beings determine some of what happens in a way that is consistent with what contemporary neuroscience shows. Thus, contemporary neuroscience does not undermine this notion of human voluntary agency; or, then, the predominant theological view that we are morally responsible in our relationship with God.
A critical edition of the Athis und Prophilias fragments with introduction, commentary, rhyme- and word-lists
Keywords: Middle High German
word-lists
narrative poetry
critical edition
Athis und Prophilias
German poetry
commentary
rhyme-lists

The introduction contains separate studies of the manuscripts, their orthographies, the rhymes, metre and treatment of source material. Both the orthographic studies and the rhyme—grammar reveal Athis to be a CG poem with no real evidence of Rhenish provenance. The metrical studies, dealing with vowel collision and units of one and three syllables, show how the Athis poet pursued various legitimate rhythmic options in his attempt to introduce variation to the tedium of regular alternation. The most positive results emerge from the comparison of Athis with its OF source, the Roman d'Athis. The dependence of the German text on the OF poem can be proved through misunderstandings of lines and part—lines of the Rd'A enshrined in proper names in the German text. By far the most important aspect of the German poet's adaptation is his sense of history. Ancient Rome and Athens are presented in an entirely different way in the German text. In particular, the large scale descriptions of ceremonies and major events are scenically developed under the influence of medieval historiographic ideas. Further supplementary source material is provided by a Pseudo—Ovidian treatment of Pyramus and Thisbe and a number of medieval military and judicial customs associated with Roman models. In general Athis is shown to be indebted to a medieval German self—awareness of Romanitas.
Disaggregating state capacity: explaining policy effectiveness in Latin America, 1996-2006
Keywords: Latin America
State capacity
Chile
Argentina
Policy effectiveness

In this thesis, I use the concept of state capacity to account for cross-national levels of variation in policy effectiveness in Latin America between 1996 and 2006. In doing so, I make four contributions to the literature. Firstly, I develop a theoretically-grounded conceptualization and an empirically systematic measurement of policy effectiveness for 18 Latin American countries along security, welfare and economic policy dimensions. Secondly, I develop a novel conceptualization and operationalization of state capacity along three key dimensions – infrastructural power, bureaucratic capacity and political capacity. By disaggregating state capacity into these three distinct (but mutually reinforcing) constituent dimensions, I integrate different strands of the literature on state capacity and purport to increase the explanatory power of state capacity as a conceptual variable. Thirdly, I develop a simple but theoretically differentiated model of policy effectiveness which maps out and incorporates different kinds of politics-centred explanations of effectiveness, while situating state capacity as a direct (but not exclusive) cause of effectiveness. The final contribution is empirical: I triangulate statistical methods, crisp-set qualitative comparative analysis and an extended qualitative comparison of two countries (Argentina and Chile) along three policy areas (health, citizen security and economic regulation) to provide a rich analysis of the influence the different dimensions of state capacity have on each policy effectiveness dimension. My results suggest, firstly, that state capacity differences are indeed large and important for explaining within-region differences in effectiveness; secondly, that the use of this disaggregated approach provides important theoretical and empirical payoffs for understanding the multiple ways in which states affect outcomes; and thirdly, that differentiating ‘institutions as organizations’ (such as the state) from the standard understanding of ‘institutions as rules’ allows us to improve on standard institutionalist accounts of the influence of politics on development.
Popular history and fiction: the myth of August the Strong in German literature, art, and media
Keywords: historiography
historical narrative
myth
August the Strong
galanterie
Friedrich August
eighteenth century
GDR
re-enactment
fiction
romance
Saxony
media
history
festival culture
Poland
historical novel

This thesis concerns the function of fiction in the creation of an historical myth and the uses that that myth is put to in a number of periods and differing régimes. Its case study is the popular myth of August the Strong (1670-1733), Elector of Saxony and King of Poland, as a man of extraordinary sexual prowess and the ruler over a magnificent, but frivolous, court in Dresden. It examines the origins of this myth in the late seventeenth and early eighteenth century, and its development up to the twenty-first century in German history writing, fiction, art, and media. The image August created for himself in the art, literature, and festivities of his court as an ideal ruler of extremely broad cultural and intellectual interests and high political ambitions and abilities linked him closely with eighteenth-century notions of galanterie. This narrowed the scope of his image later, especially as nineteenth-century historians selected fictional sources and interpreted them as historical sources to present August as an immoral political failure. Although nineteenth-century popular writers exhibited a more varied response to August’s historical role, the negative historiography continued to resonate in later history writing. Ironically, the myth of August the Strong represented an opportunity in the GDR in creating and fostering a sense of identity, first as a socialist state with historical and cultural links to the east, and then by examining Prusso-Saxon history as a uniquely (East) German issue. Finally, the thesis examines the practice of historical re-enactment as it is currently employed in a number of variations on German TV and in literature, and its impact on historical knowledge. The thesis concludes that, while narrative forms are necessary to history and fiction, and fiction is a necessary part of presenting history, inconsistent combinations of the two can undermine the projects of both.
Genetic susceptibility to common mycobacterial diseases
Keywords: mycobacteria
susceptibility
genetics
leprosy
tuberculosis

Common mycobacterial diseases, including tuberculosis and leprosy, contribute to major mortality and morbidity worldwide. Despite evidence of an important role of host genetic factors in susceptibility to these infections, few compelling genetic associations have been identified with previous candidate gene and linkage approaches.
This thesis investigates the genetic factors of human immunity to these mycobacterial diseases using a high-throughput approach of association testing. To assess genetic susceptibility to tuberculosis, I have conducted a genome-wide association study in the Gambian population as part of the Wellcome Trust Case Control Consortium (WTCCC). The study reveals the region flanking CADM1 as a potential susceptibility locus. Combining this study with a Ghanaian cohort further implicates two genetic loci at chromosome 18q11.2 (P = 9.2x10⁻⁹) and PARD3B (P = 1.4x10⁻⁶). For leprosy, I have performed a gene-centric association study in the New Delhi Indian population. Evidence of significant association was observed in the HLA-DRB1/DQA1 (P = 4.9x10⁻14 and TLR1 (P = 1.7x10⁻⁹) loci. These studies identify important genomic regions that may be involved in immunity to tuberculosis and leprosy. Further analysis revealed a significant immunogenetic overlap between tuberculosis and leprosy. This provides proof-of-principle for the subsequent aggregate analysis for mycobacterial susceptibility, which suggests that the steroid biosynthesis pathway may be important in anti-mycobacterial immunity.
This thesis represents one of the largest studies to identify the genetic factors for human immunity against mycobacteria. These novel findings will further enhance vaccine and pharmaceutical efforts into prevention and treatment of these mycobacterial diseases.
Electron microscopy study of radiation damage in tungsten and alloys
Keywords: radiation damage
microscopy
tungsten

The displacement damage induced by primary recoils of fusion neutrons in tungsten and alloys has been studied with self-ion irradiations, followed by damage characterization with electron microscopy. Tungsten and alloys (≤ 5 wt.% Re, Ta, V) were implanted with 2 MeV W+ ions over a dose range of 3.3×1017 - 2.5×1019 W+m-2 at temperatures ranging from 300 to 750°C. Dislocation loops of b = ½<111> (> 60%) and b = <100> were identified, and that ½<111> loops were found more thermally stable. Among loops that were large enough for nature determination, at least 50% were found to be of interstitial type, with larger fractions in high-temperature and high-dose conditions. The diameter of loops did not exceed 20 nm, with the majority being ≤ 5 nm. The loop number density varied between 1022 and 1023 m-3. The effects of ion dose, irradiation temperature, composition and grain orientation on damage microstructure were investigated.
In-situ irradiations (150 keV W+ ions) were carried out as a complement to the bulk implantations. Qualitative trends in loop size, geometry and nature with irradiation dose and temperature were similar to bulk irradiated specimens. Also, the dynamics of defects and their effects on the damage evolution were explored. In-situ annealing of irradiated thin foils was performed to investigate the thermal stability of radiation damage in tungsten. The majority of microstructure transformations were completed within 15 min of annealing. However, extended durations did favour the increase of loop size and the fraction of ½<111> loops.
Politics, subjectivity and the public/private distinction
Keywords: Raphael Samuel
public sphere
Christopher Lasch
public/private
Habermas
Herbert Masrcuse
American New Left
Stuart Hall
civil society
political/non-poltical
intellectual history
private sphere
necessity/freedom
Hegel
Arendt
Liberalism
C Wright Mills
Marx
equality/liberty
political theory
Richard Sennett
British New Left
EP Thompson
Charles Taylor

A critical investigation of the public/private distinction as it has been conceived in Anglo-American political thinking in the second half of the 20th century. A broadly held consensus has developed amongst many theorists that public/private does not refer to any single determinate distinction or relationship but rather to an often ambiguous range of related but analytically distinct conceptual oppositions. The argument of this thesis is that if we approach public/private in the search for analytic or conceptual clarity then this consensus is correct. Against this I propose that a number of the most dominant invocations of the distinction can be understood to express public/private as an irreducibly political dialectic that mediates the relationship between the subjective and objective side of social and political life. By locating these conceptually diverse invocations within a broader and more determinate framework of the historical development and contestation of the boundaries which establish the conditions for subjectivity, as the assertion of political agency, on the one hand, and which demarcate, police and defend these particular boundaries, as part of the objectively given character of social life and institutional organisation, on the other hand, then a more determinate character to public/private can be recognized. I then seek to explore the capacity of this model to capture and explain the peculiar post-war problematisation of public/private amongst a number of new left thinkers in Britain and America.
Unifying the epidemiological, ecological and evolutionary dynamics of Dengue
Keywords: disease
albopictus
stochastic
ecology
aedes
meta-population
tropical
neglected
evolution
vector-born
multi-strain
urban
dengue fever
aegypti
epidemiology
dengue
flavivirus

In under 6 decades dengue has emerged from South East Asia to become the most widespread arbovirus affecting human populations. Recent dramatic increases in epidemic dengue fever have mainly been attributed to factors such as vector expansion and ongoing ecological, climate and socio-demographic changes. The failure to control the virus in endemic regions and prevent global spread of its mosquito vectors and genetic variants, underlines the urgency to reassess previous research methods, hypotheses and empirical observations. This thesis comprises a set of studies that integrate currently neglected and emerging epidemiological, ecological and evolutionary factors into unified mathematical frameworks, in order to better understand the contemporary population biology of the dengue virus. The observed epidemiological dynamics of dengue are believed to be driven by selective forces emerging from within-host cross-immune reactions during sequential, heterologous infections. However, this hypothesis is mainly supported by modelling approaches that presume all hosts to contribute equally and significantly to the selective effects of cross-immunity both in time and space. In the research presented in this thesis it is shown that the previously proposed effects of cross-immunological reactions are weakened in agent-based modelling approaches, which relax the common deterministic and homogeneous mixing assumptions in host-host and host-pathogen interactions. Crucially, it is shown that within these more detailed models, previously reported universal signatures of dengue's epidemiology and population genetics can be reproduced by demographic and natural stochastic processes alone. While this contrasts with the proposed role of cross-immunity, it presents demographic stochasticity as a parsimonious mechanism that integrates, for the first time, multi-scale features of dengue's population biology. The implications of this research are applicable to many other pathogens, involving challenging new ways of determining the underlying causes of the complex phylodynamics of antigenically diverse pathogens.
Role of Notch ligands in tumour angiogenesis
Keywords: JAG1
DLL4
Angiogenesis

The well conserved Notch signalling pathway plays a crucial role in vascular development and physiology. Delta-like 4 (DLL4) and Jagged1 (JAG1) are two key notch ligands implicated in angiogenesis. Both ligands were shown to have opposite effects on vasculature. DLL4-Notch signalling inhibits sprouting resulting in fewer but better perfused blood vessels, promoting tumour growth. In contrast to DLL4, very little is known about JAG1- Notch signalling in tumour angiogenesis and its influence on tumour growth and progression. The overall aim of this work is to study the functional difference between DLL4 and JAG1-Notch signalling. The effects of murine DLL4 and murine JAG1 over-expression on tumour growth and angiogenesis was also investigated in a mouse U87 xenograft model. Firstly, the downstream target genes of DLL4 and JAG1-Notch signalling were established through microarray and QPCR. Angiogenic assays such as sprouting, network formation and migration assays were employed to study the functional effects of these two ligands in endothelial cells. The thesis firstly demonstrates that JAG1 has opposing effects on endothelial cells compared to DLL4 by increasing sprout coverage and network formation. JAG1 is less potent than DLL4 in stimulation of Notch target genes in primary endothelial cell (HUVEC) but both displayed equal potency in HMEC-1, an immortalised endothelial cell line. The growth of U87 cell lines which over-expressed murine DLL4 or murine JAG1 was slower compared to wild-type U87 cell line in vitro. JAG1- and DLL4- Notch signaling have different effects on vessel formation, which impacted on the tumour growth in vivo. Interestingly, tumours over-expressing mDLL4 had less but larger vessels compared to control, whereas mJAG1 produced more yet functional vessels; both tumours had significantly reduced pericyte coverage. Both U87 mDLL4 and mJAG1 over-expressing tumours showed increased resistance towards anti-VEGF therapy, compared to control tumours. Sensitivity to therapy was restored in combinational treatment with DBZ and bevacizumab. The mechanism behind the differential responsiveness of the Notch receptors to DLL4 or JAG1 ligands could either reflect modulation by fringes, a family of glycosyltransferases that regulate Notch signalling or by a positive feedback loop present for DLL4-Notch signalling only. Fringe was found to be abundantly expressed in endothelial cells and highly vascularised tumours. This work has highlighted some key novel differences between the two Notch Ligands.
Structural studies of integrin activation
Keywords: integrins
NMR
cell adhesion
proteins
cell migration
structural biology
nuclear magnetic resonance
talin

Fundamental to cell adhesion and migration, integrins are large heterodimeric membrane proteins that link the extracellular matrix to the actin cytoskeleton. Uniquely, these adhesion receptors mediate inside-out signal transduction, whereby extracellular adhesion is activated from within the cell by talin, a large cytoskeletal protein that binds to the cytoplasmic tail of the β integrin subunit via its PTB-like F3 domain. Features of the interface between talin1 and small β3 fragments only have been described previously.
Through NMR studies of full-length integrin β tails, we have found that β tails differ widely in their interactions with different talin isoforms. The muscle-specific β1D/talin2 complex exhibited particularly high affinity, leading to the X-ray crystal structure of the β1D tail/talin2 F2-F3 complex. Further NMR and biological experiments demonstrated that integrin activation is induced by a concerted series of interactions between the talin F3 domain and the β tail and between the talin F2 domain and the cell membrane. Additional studies revealed the structural determinants of tight talin2/β1D binding and the basis of more general differences between β1 and β3 talin binding.
NMR studies were also performed on tyrosine-phosphorylated integrin tails binding to the PTB domains of talin1 and Dok1, an inhibitor of integrin activation; these revealed that phosphorylation can inhibit integrin activation by increasing the affinity of the β tail for talin competitors. Key residues governing this switch were identified, and proteins were engineered with reversed affinities, offering potentially useful biological tools. Taken together, these results reveal the remarkable complexity of structural features that enable talin and its competitors to mediate this important form of transmembrane signalling.