VictorJuiz/thesis huggingface dataset:
The Individualization of Risk as Responsibility and Citizenship: A Case Study of Chemical Body Burdens
Keywords: environmental sociology
consumer-citizenship
mothering
risk

This dissertation examines how changing conceptions of risk responsibility relate to changing ideas of citizenship and the public sphere. Using the empirical case study of chemical body burdens, and drawing on focus groups and in-depth interviews, in addition to a twenty-year framing analysis of Canadian news media coverage of environmental contamination, this dissertation examines how risks are individualized through an ideology of “precautionary consumption.” Precautionary consumption encourages self-protection through consumer-based vigilance (e.g., by buying organic produce or “natural” cleaning products) and shifts the focus away from the state’s responsibility to regulate human and environmental exposure to contaminants. Three key findings emerge from this research. First, over twenty years of Canadian media coverage, precautionary consumption is increasingly prominent in shaping the problem frame around chemical contamination. As a media frame, the ideology of precautionary consumption reconceptualises chemical body burdens as an environmental problem affecting everyone equally to an individual problem that afflicts unaware consumers. Second, interview data suggests that the practice of mediating individual exposure to chemicals is overwhelmingly characterized as a caregiving responsibility requiring a mother’s vigilance. Interview respondents interpreted this responsibility through a dual ideological lens comprised of intensive mothering and precautionary consumption. Interviews with mothers from low-income households furthermore suggest that practices of chemical mediation vary by social class, and that access to protective commodities is highly uneven. Third, interview data also suggest that respondents viewed vigilant shopping practices as part of accepting greater personal responsibility for chemical pollution as a health threat and larger environmental problem. Respondents dismissed the transformative potential of the state in addressing body burdens; in contrast, they expressed confidence in their power as consumers and in the responsiveness of the market to protect them from chemical threats. The concluding chapter of the dissertation discusses how precautionary consumption draws our attention away from the universality of risk, and the responsibilities of the state for managing body burdens as a collective risk.
Political Authority and Distributive Justice
Keywords: Political Authority
Distributive Justice
The Subject of Distributive Justice

Many political theorists agree that an equal distribution of certain goods is a requirement of justice. However, they disagree about the types of agents that possess these distributive obligations, and about the range of agents who owe these obligations to each other. Are states primarily responsible for ensuring a just distribution of income? Or, is distributive justice also the responsibility of private individuals? Do agents – whether states or individuals – possess distributive obligations to foreigners? Or, is distributive justice only a requirement within national borders? I argue that the primary subject of distributive justice is the state’s relation to its citizens. States, and not private individuals, possess distributive obligations; and states only possess these obligations to their citizens, not to foreigners. I argue first that the state possesses distinctive distributive obligations to its citizens because of the way in which it exercises political authority over them. To exercise its political authority legitimately, that is, in a way that is consistent with the free and equal nature of its citizens, I argue, the state must secure a just distribution of civil liberties, political rights, income, and opportunities. I argue second that the subject of distributive justice does not extend beyond the state’s relation to its citizens. I argue first that principles of distributive justice do not apply to the private choices of citizens on the grounds that justice demands that citizens be free to decide what to do with their lives on the basis of their own conception of the good, and not on the basis of what is best for others. I argue second that because international organizations do not exercise political authority in the same way that states do, equality is not a demand of global justice.
Philosophy of the Many: High School Philosophy and a Politics of Difference
Keywords: high school philosophy
politics of difference
social justice
inclusion

As we start a new millennium, the conviction that exclusionary practices need to be fought at all levels of society is becoming gradually more accepted. Nevertheless, as I show in this thesis, many if not most researchers on High School Philosophy (HSP) operate from what Iris Marion Young (1990) calls a logic of identity, which continues to be exclusionary even when it attempts to reach “all.” My objective in this thesis, therefore, is to map out the HSP literature in terms of Young’s “Politics of Difference,” and, by doing that, to suggest ways in which it could be more inclusive. This adaptation of Young’s Politics of Difference to HSP is presented in this thesis in six chapters. In chapter 1, I summarize the main aspects of Young’s argument. In chapter 2, I give an overview of the current literature on HSP, showing that it is scarce and scattered. This thesis’s first contribution, therefore, is as a representative, though not exhaustive, catalogue of the HSP literature. In chapter 3, I present a deeper analysis of the HSP literature, dividing it into two main strands, “the selective” and the “universal” approaches to HSP. I also argue in this chapter that both these approaches are problematic, because they exclude many, privileges some over others and alienate all. In chapter 4, I present a brief analysis of the epistemology informing both the selective and the universal approaches to HSP. In this chapter, I focus on the so-called “Myth of Neutrality,” which is another manifestation of the logic of identity. Using as illustration the works of two authors, Robert Simon and Harvey Siegel, I show in this chapter how the myth of neutrality manifests the positivism and reductionism typical of the logic of identity. Finally, in chapter 5 I present my positive proposal for HSP, which I called “Philosophy of Many” (PoM), as a more inclusive alternative to both the selective and the universal approaches to HSP. The final chapter reviews the main conclusions of this study and suggests direction for further research.
The Dynamic Effects of Educational Accountability
Keywords: Dynamic gaming
Dynamic incentives
Ratchet effects
Education production
Educational accountability
Economics of Education

Holding educators more accountable for the academic achievement of their students has been a central feature of recent education reforms. In several prominent instances, accountability schemes have set pecuniary performance targets that condition on prior scores as a means of controlling for student heterogeneity. Yet doing so introduces a potential dynamic distortion in incentives: teachers may be less responsive to the reform today in an effort to avoid more onerous targets in future — an instance of the so-called `ratchet effect.' The main chapters of this thesis consider possible dynamic distortions from three distinct but related vantage points. Chapter 2 builds a theoretical foundation for understanding the origin of ratchet effects in an educational context. Given an environment where school-level targets depend on student prior scores, I show that such dynamic gaming behaviour depends crucially on variation in the grade horizon of students, with teachers distorting their effort less when their decision affects fewer future scores within the same school. Chapter 3 analyzes the ratchet effect from an empirical perspective. Making use of rich educational panel data from North Carolina, I exploit variation in the grade span of schools to identify ratchet effects, finding compelling evidence of dynamic distortions using a difference-in-differences approach. I then directly estimate the structural parameters of the corresponding model, allowing for complementarities in production between teacher effort and student ability. Using these estimates, the grade five score in K-5 schools would be about 1.25 standard deviations lower under a counterfactual setting without any accountability scheme and 4.6% of a standard deviation higher if ratchet effects were eliminated via a prescribed reduction in each school's incentive target. Chapter 4 explores a potentially important class of mechanisms through which the identified dynamic effects might arise. In particular, school principals may re-allocate teachers across classrooms differentially by grade. By examining the yearly change in teacher assignments to tested subjects, I find evidence that principals re-sort higher quality teachers to higher grades and focus more costly re-sorting on lower grades in response to the reform, which is consistent with the overarching dynamic objective and results of the prior chapter.
Closed-loop Control of Electrically Stimulated Skeletal Muscle Contractions
Keywords: functional electrical stimulation
spinal cord injury
closed-loop control

More than one million people are living with spinal cord injury (SCI) in North America alone. Restoring lost motor function can alleviate SCI-related health problems, as well as markedly increase the quality of life enjoyed by individuals with SCI. Functional electrical stimulation (FES) can replace motor function in individuals with SCI by using short electrical pulses to generate contractions in paralyzed muscles. A wide range of FES applications have been proposed, but few application are actually available for community use by SCI consumers. A major factor contributing to this shortage of real-world FES applications is the lack of a feasible closed-loop control algorithm. The purpose of this thesis is to develop a closed-loop control algorithm that is suitable for use in practical FES applications. This thesis consists of three separate studies. The first study examined existing closed-loop control algorithms for FES applications, and showed that a method of testing FES control algorithms under realistic conditions is needed to evaluate their likely real-world performance. The second study provided such a testing method by developing a non-idealities block that can be used to modify the nominal response of electrically stimulated muscle in simulations of FES applications. Fatigue, muscle spasm, and tremor non-idealities are included in the block, which allows the user to specify the severity level for each type of non-ideal behaviour. This nonidealities block was tested in a simulation of electrically induced knee extension against gravity, and showed that the nominal performance of the controllers was substantially better than their performance in the realistic case that included the non-idealities model. The third study concerned the development and testing of a novel observer-based sliding mode control (SMC) algorithm that is suitable for use in real-world FES applications. This algorithm incorporated a fatigue minimization objective as well as co-contraction of the antagonist muscle group to cause the joint stiffness to track a desired value. The SMC algorithm was tested in a simulation of FES-based quiet standing, and the non-idealities block was used to determine the probable performance of the controller in the real world. This novel controller performed very well in simulation, and would be suitable for use in selected practical FES applications. The work contained in this thesis can easily be extended to a wide range of FES applications. This work represents a significant step forward in closed-loop control for FES applications, and will facilitate the development of sophisticated new electrical stimulation systems for use by consumers in their homes and communities.
Enhancing the Nitrite Reductase Activity of Modified Hemoglobin: Bis-tetramers and their PEGylated Derivatives
Keywords: Hemoglobin
Blood substitutes
Kinetic reactions
Nitrite Reductase Activity
Protein Modification
Deconvolution

The need for an alternative to red cells in transfusions has led to the creation of hemoglobin-based oxygen carriers (HBOCs). However, evaluations of all products tested in clinical trials have noted cardiovascular complications, raising questions about their safety that led to the abandonment of all those products. It has been considered that the adverse side effects come from the scavenging of the vasodilator – nitric oxide (NO) by the deoxyheme sites of the hemoglobin derivatives. Another observation is that HBOCs with lower oxygen affinity than red cells release oxygen prematurely in arterioles, triggering an unwanted homeostatic response. Since the need for such a product remains critical, it is important to understand the reactivity patterns that contribute to the observed complications. Various alterations of the protein have been attempted in order to reduce HBOC-induced vasoconstriction. Recent reports suggest that a safe and effective product should be pure, homogenous and have a high molecular weight along with appropriate oxygenation properties. While these properties are clearly important, vasodilatory features of hemoglobin through its nitrite reductase activity may also act as an in situ source of NO. It follows that HBOCs with an enhanced ability to produce NO from endogenous nitrite may serve to counteract vasoactivity associated with NO-scavenging by hemoglobin. Here we characterize the effects of different protein modifications on the nitrite reductase activity of hemoglobin. We produced a variety of HBOCs that include cross-linked tetramers, polyethylene glycol (PEG) conjugates and bis-tetramers of hemoglobin. We report that the rate of NO production strongly depends on the conformational state of the protein, with R-state stabilized proteins (PEG-Hbs), exhibiting the fastest rates. In particular, we found that PEGylated bis-tetramers of hemoglobin (BT-PEG) exhibit increased nitrite reductase activity while retaining cooperativity and stability. Animal studies of BT-PEG demonstrated that this material is benign: it did not cause significant increases in systemic blood pressure in mice, the major side effect associated with existing HBOCs. BT-PEG exhibits an enhanced nitrite reductase activity together with sample purity and homogeneity, molecular size and shape, and appropriate oxygenation properties, characteristics of a clinically useful HBOC.
The Power of Uncertainty: Algorithmic Mechanism Design in Settings of Incomplete Information
Keywords: Algorithmic game theory
Mechanism design
Auctions
Algorithms

The field of algorithmic mechanism design is concerned with the design of computationally efficient algorithms for use when inputs are provided by rational agents, who may misreport their private values in order to strategically manipulate the algorithm for their own benefit. We revisit classic problems in this field by considering settings of incomplete information, where the players' private values are drawn from publicly-known distributions. Such Bayesian models of partial information are common in economics, but have been largely unexplored by the computer science community. In the first part of this thesis we show that, for a very broad class of single-parameter problems, any computationally efficient algorithm can be converted without loss into a mechanism that is truthful in the Bayesian sense of partial information. That is, we exhibit a transformation that generates mechanisms for which it is in each agent's best (expected) interest to refrain from strategic manipulation. The problem of constructing mechanisms for use by rational agents therefore reduces to the design of approximation algorithms without consideration of game-theoretic issues. We furthermore prove that no such general transformation is possible if we require mechanisms that are truthful in the stronger non-Bayesian sense of dominant strategies. In the second part of the thesis we study simple greedy methods for resolving complex auctions. We show that while such greedy algorithms are not truthful, they suffer very little loss in worst-case performance bounds when agents apply strategies at equilibrium, even in settings of partial information. Our analysis applies to various different equilibrium concepts, including Bayes-Nash equilibrium, regret-minimizing strategies, and asynchronous best-response dynamics. Thus, even though greedy auctions are not truthful, they may be appropriate for use as mechanisms under the goal of achieving high social efficiency at equilibrium. Moreover, we prove that no algorithm in a broad class of greedy-like methods can be used to create a deterministic truthful mechanism while retaining a non-trivial approximation to the optimal social welfare. Our overall conclusion is that while full-information models of agent rationality currently dominate the algorithmic mechanism design literature, a relaxation to settings of partial information is well-motivated and provides additional power in solving central problems in the field.
The Effects of Early Social Deprivation on Appetitive Motivation in Rats
Keywords: social deprivation
motivation
artificial rearing
behavioural inhibition

Social interactions in early life influence the organization of neural and behavioural systems of developing mammalian young. Deprivation of social interactions with the primary caregiver and other immediate conspecifics (early social deprivation) has lasting consequences on behavioural functioning in later life. The purpose of this thesis was to investigate how early social deprivation affects the motivational aspects of behaviour in the context of appetitive stimuli. Rats were reared in complete isolation from the mother and litter using the method of artificial rearing (AR). Control rats were maternally reared (MR). In adulthood, rats were tested in a series of behavioural paradigms designed to assess the motivational impact of primary food reward and reward-related cues on food-seeking behaviour. AR increased the behavioural responsiveness of rats to the motivational impact of reward-related cues, but not to primary rewards themselves. Specifically, there were no significant effects of AR on food consumption or goal-directed instrumental responding for food. However, AR enhanced instrumental responding triggered by a previously conditioned reward cue. AR also increased the expression of approach behaviour towards a localizable conditioned reward cue and instrumental responding when the same cue was used as a reinforcer. An assessment of the mediating factors during development revealed that the lack of tactile stimulation normally received from the mother, but not sustained exposure to the stress hormone corticosterone, contributed to the long-term effects of AR. These findings represent a potential link between early-life social adversity and vulnerability to the development of problems with behavioural inhibition and attention in the presence of appetitive environmental cues.
The Politics of Security and the Art of Judgment in the Writings of Herman Melville and Janet Frame
Keywords: American literature
New Zealand literature
Herman Melville (1819-1891)
Janet Frame (1924-2004)
American politics
sovereignty
security

This dissertation pairs a nineteenth-century American writer, Herman Melville, and a twentieth-century New Zealand writer, Janet Frame, to consider points of overlap between two novelists who were unusually sensitive to the problem of political thinking and decision in situations of state emergency. Consisting of three chapters on Melville’s later maritime fiction (Moby-Dick, Benito Cereno, and Billy Budd, Sailor) and two interleaving chapters on Frame’s late autobiographical and fictional writings (An Angel at My Table and The Carpathians), the dissertation explores how, in the work of these writers, figural work builds around interlinked questions of emergency and judgment. Both writers are interested in situations of peril when the fragility of bodily life is exposed and when the coherence of given political orders is tested. Both probe the response of the human legislative urge and the limits of the power of judgment in the time of crisis and exception, producing narratives of the tense moment of executive decision. Their literary forms heighten awareness of the mechanisms, frameworks, and effects of different modes of judgment--whether cognitive, moral, legal, aesthetic, or political--under emergency conditions. Out of this engagement with the nexus of judgment and security, both writers ask what might happen if we were to abide with precariousness and insecurity rather than default to the often destructive praxis of security. Melville and Frame also push the capacities of language and form in their attempt to represent the possibility of modes of judgment adequate to such political renewal. In their rhetoric and formal structures--including their experimental “disfiguration” of narrative lines--and in their creation of intricate, reflexive literary voices, these writers imagine what it would mean to come up against the limit of, and even to overturn, accepted categories of knowledge and thought, of calculation and judgment.
Characterization of the Adaptor Protein XB130, a Tyrosine Kinase Substrate and a Novel Component of the Lamellipodia
Keywords: adaptor protein
tyrosine kinase
RET/PTC
PI3K
XB130
AFAP1L2
cytoskeleton
lamellipodia
papillary thyroid cancer

Adaptor proteins play a vital role in the propagation of cellular signals. Although they lack endogenous catalytic activity, they contain a variety of protein binding modules, which enable them to promote specific and efficient interactions with their binding partners. They form integrative platforms for a variety of molecules (e.g. lipids, tyrosine kinases, cytoskeletal and signaling proteins), and thereby link and coordinate key functions such as cell growth, motility and shape determination. Our laboratory has recently cloned a novel, 130 kDa adaptor protein, named XB130, as a structural homolog of actin-filament-associated-protein (AFAP-110), a stress fiber-binding Src substrate. However, the molecular interactions and functions of this novel adaptor remained to be elucidated. To characterize the function of XB130 we asked two general questions: (1) Is XB130 involved in the signal transduction pathways of tyrosine kinases? And (2) Is XB130 capable of regulating the cytoskeleton and/or is it regulated by the cytoskeleton? To address these questions first we investigated the tissue distribution of XB130 and discovered that it is abundantly expressed in thyroid. Therefore we asked whether it is a target of the thyroid-specific tyrosine kinase, RET/PTC, a genetically rearranged, constitutively active enzyme that plays a pathogenic role in papillary thyroid cancer. We found that XB130 is a RET/PTC substrate that couples RET/PTC signaling to phosphatidylinositol 3-kinase (PI3K) activation through its phosphorylation dependent interaction with the regulatory subunit p85 of PI3K. XB130 plays an important role in PI3K signaling, as downregulation of XB130 in TPC1 papillary thyroid cancer cells, harboring the RET/PTC1 kinase, strongly reduced Akt activity and concomitantly inhibited cell cycle progression and survival in suspension. In the second part we demonstrate that XB130 is a novel Rac- and cytoskeleton-regulated protein that exhibits high affinity to lamellipodial (branched) F-actin and impacts motility and invasiveness of tumor cells. In conclusion, my work characterized a novel adaptor protein and assigned two well-defined pathophysiological functions to it in the context of thyroid cancer cells.