VictorJuiz/thesis huggingface dataset:
Settlement Service Providers in Peel Region, Ontario: Challenges, Barriers and Opportunities in the Shadow State
Keywords: Immigration
Neoliberalism
Suburb
Settlement Integration

This research examines the challenges and barriers to service provision that newcomer settlement service providers (SSPs) encounter in Peel Region, Ontario. Semi-structured interviews are used to examine if suburban SSPs in the cities of Brampton, Mississauga and town of Caledon, encounter challenges related to providing services to both adult and youth newcomers. The findings indicate that government funding, and the conditions tied to that funding, are the greatest challenge for SSPs in Peel. Funding restrictions also produced challenges related to the structure and continuity of services and competition between service providers. Due to Peel's varied geography, transportation and organization location are challenges for some rural service providers. Service specific challenges are encountered largely in providing employment and mental health services. Reconsidering government policies around funding for settlement services is necessary. It is recommended that both SSPs and municipalities be integrated into settlement policy decisions.
A Microfluidic, Extensional Flow Device for Manipulating Soft Particles
Keywords: Microfluidic
particle trapping
extensional flow
tentiometry

A computer-controlled microfluidic extensional flow device is developed for trapping and manipulating micron-sized hard and soft particles. The extensional flow is generated in a diamond-shaped cross-slot that has each corner connected to a pressure-controlled liquid reservoir. By employing an imaging-based control algorithm, a particle can be made to move to an arbitrary position within the slot by adjusting the reservoir pressures and hence the fluid flow rates into/out of the slot. Thus, a soft particle can be trapped indefinitely at a point within the slot, and a known hydrodynamic force can be applied to study the dynamics of stretching and breakup of the particle. Alternatively, adhesion or coalescence dynamics of soft particles may be investigated by effecting a controlled collision between two particles. The device is validated by measuring the low interfacial tension of a compatibilized oil-water interface.
Lithium-Ion Battery Modeling for Electric Vehicles and Regenerative Cell Testing Platform
Keywords: Electric Vehicle
Lithium-Ion Battery

Electric Vehicles (EVs) have gained acceptance as low or zero emission means of transportation. This thesis deals with the design of a battery cell testing platform and Lithium-Ion (Li-Ion) battery modeling for EVs. A novel regenerative cell testing platform is developed for cell cycling applications. A 300 W - 5 V cell cycler consisting of a buck and a boost converter is designed. Furthermore, a novel battery modeling approach is proposed to accurately predict the battery performance by dynamically updating the model parameters based on the battery temperature and State of Charge (SOC). The comparison between the experimental and the model simulation results of an automotive cell under real-world drive-cycle illustrates 96.5% accuracy of the model. In addition, the model can be utilized to assess the long-term impact of battery impedance on performance of EVs under real-world drive-cycles.
Differential Effects of Chronic Fluoxetine on the Behaviour of Dominant and Subordinate Naked Mole-rats
Keywords: 5-hydroxytryptamine (5-HT)
Fluoxetine hydrochloride (Prozac)
Naked mole-rat
Social behaviour
Social status

Naked mole-rats are eusocial rodents that live in subterranean colonies with a strict reproductive and social hierarchy. Breeders are socially dominant and other colony members are non-reproductive subordinates. The effects of manipulating the serotonergic system on aggression are well studied in many species, but not in eusocial rodents like the naked mole-rat. For the current study, the effects of fluoxetine hydrochloride (FLX) on status-specific behaviours of subordinates (Experiment 1) and queens (Experiment 2) were evaluated both in-colony and in a social-pairing paradigm to investigate how the serotonergic system influences aggression in this species. In accordance with our main hypothesis, chronic treatment of FLX attenuated the frequency and duration of aggression in queens, but not subordinates, when paired with an unfamiliar conspecific. Further exploration of pharmacological manipulation on status-specific behaviours of this eusocial species may elucidate the neurobiological mechanisms underlying their unique and rigid social hierarchy.
Should the Pythagorean Theorem Actually be Called the 'Pythagorean' Theorem
Keywords: Pythagoras
Pythagorean Theorem

This paper investigates whether it is reasonable to bestow credit to one person or group for the famed theorem that relates to the side lengths of any right-angled triangle, a theorem routinely referred to as the “Pythagorean Theorem”. The author investigates the first-documented occurrences of the theorem, along with its first proofs. In addition, proofs that stem from different branches of mathematics and science are analyzed in an effort to display that credit for the development of the theorem should be shared amongst its many contributors rather than crediting the whole of the theorem to one man and his supporters.
The Role of Human Leukocyte Antigen-G in Cardiac Allograft Vasculopathy
Keywords: HLA-G
Heart Transplantation
Cardiac Allograft Vasculopathy
Immune System

Human leukocyte antigen-G (HLA-G), a non-classical MHC I protein, plays an essential role in immune tolerance and is associated with a lower incidence of graft rejection and cardiac allograft vasculopathy (CAV). To examine the pattern of HLA-G expression post-transplantation we determined that HLA-G can be up-regulated in smooth muscle cells (SMCs) following exposure to everolimus. We also determined that HLA-G at 500 and 1000 ng/ml reduces SMC proliferation. In further studies, treatment with HLA-G inhibited TNFα-stimulated neutrophil adhesion to endothelial cells (ECs) at all concentrations tested (0.1-1 ng/ml), suggesting a role in inflammation. The expression of HLA-G is influenced by a polymorphism in the HLA-G gene. We sought to determine if the 14bp insertion/deletion polymorphism can predict the development of CAV. There was no association between this polymorphism and CAV; however, this study had a small number of patients; therefore further investigations are needed to confirm these findings.
East-West Asymmetry in Coastal Temperatures of Hudson Bay as a Proxy for Sea Ice
Keywords: Sea Ice
Hudson Bay
Proxy

The seasonal asymmetry in coastal temperatures on Hudson Bay was explored and evaluated as a proxy to hindcast sea ice conditions prior to 1972. Various indices of air temperature difference (∆T) between Churchill, MB and Inukjuak, QC were tested for linear correlations with spatially averaged sea ice concentration (SIC) and ice-free season length (IFS). A multiple regression equation employing a 31-day average of peak ∆T and a 61-day average of temperature during freeze-up reproduced the IFS record with an average error of 8.1 days. This equation was employed to extend the IFS record by 28 years. The resulting 68-year time series revealed a significant increasing trend most pronounced from 1985 to 2011. Hindcast data helped eliminate low-frequency climate oscillations of periodicity <68 years as a source of this trend, lending further evidence to the growing consensus of a declining sea ice being the result of anthropogenic climate forcing.
Auditory Interface Design to Support Rover Tele-operation in the Presence of Background Speech: Evaluating the Effects of Sonification, Reference Level Sonification, and Sonification Transfer Function
Keywords: sonification
auditory
auditory display
speech
rover
tilt
reference sonification
sonification mapping
sonification transfer function
voice

Preponderant visual interface use for conveying information from machine to human admits failures due to overwhelming the visual channel. This thesis investigates the suitability of auditory feedback and certain related design choices in settings involving background speech. Communicating a tele-operated vehicle’s tilt angle was the focal application. A simulator experiment with pitch feedback on one system variable, tilt angle, and its safety threshold was conducted. Manipulated in a within-subject design were: (1) presence vs. absence of speech, (2) discrete tilt alarm vs. discrete alarm and tilt sonification (continuous feedback), (3) tilt sonification vs. tilt and threshold sonification, and (4) linear vs. quadratic transfer function of variable to pitch. Designs with both variable and reference sonification were found to significantly reduce the time drivers spent exceeding the safety limit compared to the designs with no sonification, though this effect was not detected within the set of conditions with background speech audio.
The Association of Human Papillomavirus with Oral Lesions
Keywords: human papillomavirus
oral pathology

The oral cavity is a common site for human papillomavirus (HPV) infection, however much is still unknown about the spectrum of oral lesions associated with HPV. The prevalence of HPV was investigated in oral dysplasias and papillary lesions using a combination of ISH, p16 and MIB-1 immunohistochemistry. Results show that a subset of high grade oral epithelial dysplasias demonstrated evidence of high-risk HPV infection. Follow-up information suggests a difference in the behaviour of HPV-positive and HPV-negative high grade dysplasias. Oral papillary lesions are a heterogeneous group with variable clinical behaviour. Results support an association of low-risk HPV with papillary lesions that run a benign clinical course, despite the presence of atypia. Other oral papillary lesions with atypical features represent potentially malignant lesions that may progress to carcinoma. Potentially malignant and malignant papillary lesions are not associated with HPV infection. Infection with low versus high-risk HPV results in distinct clinical manifestations.
Metalloporphysomes: Engineering New Metalloporphyrin Nanoparticles
Keywords: Nanomedicine
Imaging
Cancer
PET
MRI
Porphyrins

Porphyrins are naturally occurring molecules. Porphysomes are simple multimodal nanoparticles that derive their multifunctionality from porphyrin-based building-blocks. While previous studies have probed their interactions with light, their capacity to stably chelate metal ions has gone largely uninvestigated. Herein are presented and discussed two investigations into metalloporphysomes. First is a method for non-invasively labeling porphysomes with radioactive copper-64. Utilizing exceptionally simple chemistry, this method produces a highly stable radiotracer capable of both PET and fluorescence imaging. Second is a profile of a MRI-detectable, photothermal agent whose photonic properties are serendipitously improved by the incorporation of MRI-active metal ions. By taking advantage of simple chemical substitutions, these studies illustrate methods of accessing new functionalities while maintaining a deeply simple construct, an often overlooked aspect in the development of multimodal nanoparticles.
Software Based GPU Framework
Keywords: GPU
3D graphics
Gallium3D
LLVM
Mobile GPU
Software GPU

A software based GPU design, where most of the 3D pipeline is executed in software on shaders, with minimal support from custom hardware blocks, provides three benefits, it: (1) simplifies the GPU design, (2) turns 3D graphics into a general purpose application, and (3) opens the door for applying compiler optimization to the whole 3D pipeline. In this thesis we design a framework and a full software stack to support further research in the field. LLVM IR is used as a flexible shader IR, and all fixed-function hardware blocks are translated into it. A sort-middle, tile-based, architecture is used for the 3D pipeline and trace-file based methodology is applied to make the system more modular. Further, we implement a GPU model and use it to perform an architectural exploration of the proposed software based GPU system design space.
The Role of TLR3 in the Development of Lupus-like Autoimmunity in B6.NZBc13 Mice
Keywords: Autoimmunity
mouse model
SLE

The New Zealand Black (NZB) mouse chromosome 13 (c13) is linked to development of autoimmunity. B6 mice containing a portion of NZBc13 (B6.NZBc13 (c13)) develop a lupus phenotype that includes: autoantibody production, increased B and T cell activation, and marginal zone B cell and myeloid dendritic cell expansions. c13 mice have a B cell intrinsic dsRNA-sensing defect, leading to increased TLR3 expression and survival. The role of the aberrant dsRNA sensing in the generation of the c13 autoimmune phenotype was assessed by generating c13 mice with TLR3 knocked out (c13.TLR3KO). Marginal zone B cell expansion and B cell activation were attenuated in c13.TLR3KO mice, but other cellular phenotypes were not affected. Autoantibody production was partially reduced. These results indicate that altered dsRNA-sensing contribute to a portion of the altered cellular phenotypes in c13 mice, but that other susceptibility loci in the c13 interval are required for full development of autoimmunity.
Design and Evaluation of a Mobile Health Application for Adult Patients with Type 1 Diabetes Mellitus
Keywords: eHealth
User Centred Design
mobile
diabetes
adolescents

In this study, a user-centred design approach was used to develop a mobile health application designed to support adult T1DM patients with their self-management routine. In the requirements gathering phase, an observational study of a diabetes clinic and patient interviews were conducted. An analysis of the data collected from this phase helped identify the functional design requirements used to guide the design. Using a rapid prototyping approach, data visualizations, game-based elements, carb-counting and social networking features were explored. The final prototype developed in this research was evaluated for its ease of use and perceived usefulness. The design was found to be generally easy to use. With respect to data visualizations, participants preferred the scatter plot view of their blood glucose readings to a bar chart. In addition, it was found that all participants wanted a way to track their HbA1c on a regular basis.
In Vitro Human Engineered Myocardium: A Study into both Pathological and Physiological Hypertrophy
Keywords: Cardiomyocyte
Stem Cells
Tissue Engineering
Disease Modelling

The ability to generate cardiomyocytes from either embryonic stem cells or induced pluripotent stem cells provides an unprecedented opportunity to establish human in vitro models of cardiovascular disease as well as to develop platforms for the testing of novel cardiac therapeutics. We designed two different platforms, a biowire platform and post deflection platform, to generate engineered heart tissues (EHTs) to study a fundamental process in cardiomyocytes: hypertrophy. Both pathological and physiological hypertrophy was studied in order to garner a better understanding of each process. Physiological hypertrophy characteristics were observed using the biowire platform seen in improved myofibril alignment and downregulation of fetal genes. When electrical stimulation was added, a rate dependent effect on sarcomere maturation was observed by the increased frequency of I-bands and H-zones. Certain hallmark features of pathological hypertrophy, such as upregulation of brain natriuretic peptide and sarcomere structure breakdown, were recapitulated when EHTs were treated with isoproterenol.
Keeping in Touch or Keeping Score? Social Comparisons on Facebook
Keywords: Social comparisons
Facebook
Self-esteem

In face-to-face contexts, individuals typically make one social comparison per day and make more self-enhancing downward comparisons (to worse-off others) than potentially threatening upward comparisons (to better-off others). However, online social networks such as Facebook may be radically altering these standards. In two studies, I examined the frequency, direction, and impact of social comparisons on Facebook, and investigated potential moderating factors, including self-esteem. Participants reported making more upward than downward Facebook comparisons (Studies 1 and 2) and made an average of four comparisons in a 20-minute Facebook session (Study 2). Both low self-esteem and being motivated to log onto Facebook to get information with others predict making more comparisons on Facebook (Study 1) and participants with lower self-esteem may feel worse about themselves after making both upward and downward Facebook comparisons compared to their higher self-esteem peers (Study 2).
Awakening the 'Sleeping Beauty of the Peace Palace' - The Two-dimensional Role of Arbitration in the Pacific Settlement of Interstate Territorial Disputes Involving Armed Conflict
Keywords: Public international law
Conflict resolution
Arbitration
Interstate territorial disputes

Interstate arbitration is commonly viewed as an essentially judicial process, suitable for the resolution of legal questions but inappropriate to deal with “political” issues. This conception, however, arguably flies in the face of both the origins and historical function of interstate arbitration and the complex legal-political nature of most interstate disputes. This paper offers an alternative account of interstate arbitration, which views it as a sui generis hybrid mechanism that combines “legal” and “diplomatic” dimensions to effectively resolve all aspects of interstate disputes. The paper examines this proposed account by analyzing four complex interstate territorial disputes that were submitted to arbitration and assessing the extent to which these two dimensions were recognized and employed, and how this may have affected the resolution of the disputes. Based on this analysis, the paper offers a two-dimensional operative framework intended to guide states and arbitrators in the resolution of future complex interstate disputes.
Design and Development of Ground Segment Software and Hardware for Nanosatellie Space Missions
Keywords: nanosatellite
testing
mission planning

Contributions to two nanosatellite missions are discussed. First, the design and development of a test system for an advanced nanosatellite power board is discussed. Details of software and hardware design process involved in the implementation of automated test procedures are presented. The system has been deployed for unit-level testing of power boards for several nanosatellite missions, significantly reducing testing cost and time. Next, a Mission Planning and Scheduling Software platform is proposed for Earth Observation missions. The motivation is described for the development of a stand-alone application enabling satellite operations teams to identify suitable observation scenario parameters. Attitude and orbital trajectory estimation algorithms constituting the computational model are integrated and implemented within a graphical visualization environment to allow interaction with the user in an efficient and intuitive manner. Key results of major component-level testing are presented, showing the behaviour and accuracy of analytical components satisfy mission requirements.
Time-dependent Transformation of Episodic Memories
Keywords: Episodic Memory
Transformation
Consolidation

Although there has been over a century of research on memory and consolidation, there remains no consensus with respect to the nature of episodic memories over time. This study tests two prominent theories (Standard Consolidation Theory and Trace Transformation Hypothesis), which make opposing predictions as to the quality of remote episodic memory, by investigating memories for film clips. Using true/false questions to test recall immediately, 3 days, and 7 days after encoding, these experiments demonstrate that details (both perceptual and story-line details) are lost, while the gist of memories is maintained over time. These data also suggest that gist and detail may be maintained independently in the brain. These results broaden our understanding of recent and remote memory, and provide support for the transformation view of consolidation. In the future, the transfer of this paradigm to neuroimaging will allow us to investigate the neural basis of episodic memory over time.
Dynamic Linkage Between Local Cross-frequency Coupling and Communication Through Coherence in an in Vitro Model of Human Neocortical Oscillatory Activity
Keywords: Cross Frequency Coupling
Modulation Index
Communication Through Coherence
Phase Coherence
Human
Intralaminar
Cortex
Electrophysiology

The dynamical underpinnings of complex computation and information transmission within the brain, while of great interest to the neuroscience community at large, remain poorly understood. One of the striking manifestations of neuronal population activity is that of rhythmic oscillations in the local field potential. It is thought that distinct patterns of these oscillations such as cross-frequency coupling within a given spatial location and coherence between disparate brain regions may represent neuronal computation and communication, respectively. Here we show such dynamics within a human temporal neocortical in vitro model. In specific, we show theta-gamma cross frequency coupling in deep and superficial layers, phase coherence between layers at theta frequencies, and a measure of communication (phase dependent power correlations) between layers at theta frequency. Additionally, we show a novel correlation between communication across layers and cross frequency coupling within layers, demonstrating a dynamic link between local computation and intralaminar communication.
The Effects of Over-reporting and Under-reporting Response Bias on the Personality Inventory for DSM-5 (PID-5)
Keywords: DSM-5
MMPI-2-RF
non-credible responding
over-reporting
under-reporting
personality disorders
Personality Inventory for DSM-5
PID-5
response bias
validity scales
invalid responding
PD diagnosis

Accurate self-report assessment of psychopathology depends on individuals responding honestly and accurately. Some respondents, however, may respond in a manner not representative of their traits/symptoms. The MMPI-2-RF contains “validity” scales to detect elevations on over-reporting (OR) or under-reporting (UR) scales which typically correspond to elevations on MMPI-2-RF substantive scales and on instruments administered alongside the MMPI-2-RF. We examined effects of OR and UR on the Personality Inventory for DSM-5 (PID-5); a self-report instrument that assesses 25 pathological traits used with other diagnostic criteria to diagnose personality disorders (PDs) in Section III of the DSM-5. Using MMPI-2-RF validity scale scores, 908 students and 255 psychiatric outpatients were classified into OR, UR or within normal limit response groups. Significant group differences were found such that differences in the frequency of PD diagnosis emerged across response groups. We believe the PID-5 is vulnerable to OR and UR responding, which potentially compromises its validity.