VictorJuiz/thesis huggingface dataset:
Avian malaria associations with British mosquitoes
Keywords: local-scale
mosquito
landscape ecology
seasonal heterogeneity
spatial heterogeneity
Parus major
Avian malaria
host-parasite-vector associations
Cyanistes caeruleus
wild populations
British woodland
Plasmodium
great tit
environmental predictors
mosquito density per host
blue tit

Avian malaria (Plasmodium spp.) is a popular model system to study the ecology and evolution of parasite-host-vector interactions in the wild. These studies have historically focused mostly on the avian hosts and the malaria parasites. Knowledge regarding the role of vectors is essential to our understanding of these wild systems, but has only very recently started to accumulate.
This thesis aimed to contribute to this field by assessing mosquito-malaria-host associations for British mosquitoes and the role of mosquito ecology in shaping these parasite systems in a British woodland study site, using molecular, field ecology and statistical modelling methodologies. From the 12 mosquito species or species groups found, I showed that the Cx.pipiens/torrentium mosquito group is likely to have a major role in avian malaria transmission in Great Britain, while Cs. annulata may be transmitting P. circumflexum. I also demonstrated a positive spatial association between mosquito density per host and avian malaria prevalence, in accordance with theoretical expectations for malaria transmission. Findings here provide evidence that avian malaria transmission in British woodlands is limited mainly to June-August, being preceded by relapse of previous infections or, alternatively, by maintenance of chronic blood parasitaemia through the colder months; this agrees with theoretical expectations and findings elsewhere for temperate climates.
This thesis also described local-scale spatial heterogeneity and seasonal variation in adult mosquito abundance within a British woodland where avian malaria is endemic, with differing patterns found between species or species groups. Spatially, variation in adult mosquito abundance was associated with microclimatic and landscape variables such as distances to mosquito breeding sites, microclimate and canopy height; seasonally, variation in mosquito abundance was associated with temperature and rainfall, alongside calendar date. The heterogeneity in mosquito parameters and associations with environmental variables found at a site where avian malaria is endemic highlights the need to anticipate such complexity when trying to understand Plasmodium transmission. By doing so, we further extend the potential of these parasite systems to improve our knowledge regarding the ecology and evolution of parasite-host-vector associations.
Politics of change:  energy efficiency policy in Britain and Germany
Keywords: energy efficiency
energy policy
policy change

Britain and Germany are two countries that are internationally recognised for their energy efficiency policies in the area of domestic buildings. Although pursuing similar objectives, the two countries have quite different flagship policies: Germany put in place a large loan and grant scheme to finance residential energy efficiency measures in 2001, the CO2-Building Rehabilitation Programme. The UK was the first country in Europe that introduced Energy savings obligations in 1994. Since then the policy instruments in both countries experienced significant change. This thesis explores the politics of the changes that occurred, and investigates the policy processes that led to the modifications. Mainstream theories of policy change emphasise short-term crisis-like events when it comes to explaining why policies change significantly. However, more recent theoretical approaches suggest that gradual mechanisms, including accumulating external pressures and slowly developing consequences of the policies themselves, play an important role as well. In order to approach the two cases theoretically, this thesis draws on the concept of friction developed in Punctuated Equilibrium Theory and the policy feedback literature. This thesis investigates how long-term pressures, for example the perceived impact of climate change and rising energy prices, affected the evolution of the key home energy efficiency policies in Britain and Germany. Combined with assessing the impact of institutional changes and policy feedback, a comprehensive analysis of long-term policy change is carried out. A set of different methods is employed to undertake the investigation including qualitative and quantitative research methods such as semi-structured interviews with more than 25 experts followed by qualitative content analysis, complementary document analysis, and the review of data sets. The analysis provides a detailed historical case study of the key home energy efficiency policy instruments in Germany and the UK with a focus on the causal mechanisms of gradual pressures. Wider conclusions are drawn for the theories of policy change and how gradual pressures might be accounted for in those theories in a more meaningful way.
The theory of tragedy in Germany around 1800: a genealogy of the tragic
Keywords: The Tragic
German Idealism
Greek tragedy

The thesis focuses on the theory of tragedy in Germany around 1800, and has two primary aims: to demonstrate the importance of idealist thought for contemporary approaches to tragedy and the tragic; and to revise the intellectual historiography of the classic phase in German letters. It traces reflection on Greek tragedy from the Querelle des anciens et des modernes in France around 1700 through the aesthetic systems formulated in Germany around 1800. Two intellectual developments are emphasized: the historicist consciousness that develops throughout the eighteenth century and places Greek tragedy more radically in its cultural context than ever before; and the idealist philosophy of art, which seeks to restore a measure of universality to the ancient genre, seeing it as the manifestation of a timeless quality of ‘the tragic.’ These two impulses, historicizing and universalizing, it is argued, are fundamental to modern understanding of Greek tragedy. The genealogical method seeks to establish a greater continuity with earlier eighteenth-century thought than is generally recognized, and to refute the teleologies that dominate accounts of idealist thought. A reconstruction of the central texts of Schiller, Schelling, Hegel, and Hölderlin reveals that the theory of tragedy around 1800 is in large part a reflection on history, an effort to understand how ancient literature can be meaningful in modernity. Greek tragedy becomes the ground for an engagement with the pastness of antiquity and its possible presence. Idealist theories, far from dissolving particularity in abstraction, seek a mediation between philological historicism and philosophical universalism in considering Greek tragedy. A genealogy of the tragic suggests that such mediation remains a vital task for scholars of the Classics.
Investigations of the role of d-amino acid oxidase and serine racemase in schizophrenia
Keywords: schizophrenia
serine racemase
d-serine
d-amino acid oxidase

D-serine metabolism is implicated in schizophrenia pathophysiology. This is based on reduced D-serine levels in the disorder, its ameliorative effects therapeutically and the potential genetic contributions of its metabolic enzymes, D-amino acid oxidase (DAO) and serine racemase (SRR). D-serine is a gliotransmitter and the N-methyl D-aspartate receptor (NMDAR) co-agonist. Thus, altered D-serine metabolism may contribute to NMDAR hypofunction in schizophrenia. The research in this thesis was designed to investigate D-serine metabolic enzymes further through studying their distribution, their expression in schizophrenia and their effect on NMDARs.
The regional and cellular distribution of DAO and SRR in rodent and human brain were investigated using immunohistochemistry. Both enzymes were found within frontal cortex, hippocampus and cerebellum. In rodent frontal cortex, SRR expression was neuronal suggesting D-serine is not always glia-derived. In the human this was not the case, highlighting possible species differences. DAO in the rodent and human cortex was robustly detected, challenging previous views. In rodent cerebellum, both enzymes were neuronal and glial and in human, predominantly glial. In schizophrenia, DAO and SRR expression were investigated using western blotting and real-time PCR. DAO expression was elevated in the cerebellum in the disorder, without an accompanying change in SRR. In the dorso-lateral prefrontal cortex (DPFC), DAO and SRR mRNAs were unchanged in schizophrenia but SRR protein was significantly increased. The elevation in DPFC SRR protein was not replicated however in a second study. To investigate the effects of D-serine metabolic enzymes on NMDARs, an in vitro model of altered SRR expression was developed, but its use hindered through technical complications.
The data detailed demonstrate new findings of DAO and SRR’s distributions in the brain and highlight novel potential roles for these enzymes. In addition, the data provide some paradoxical findings including DAO’s cortical expression. The investigations in schizophrenia lend to robust demonstrations of DAO’s elevated cerebellar expression in the disorder. However, its roles therein and that of DAO and SRR on NMDAR function remain unclear.
Comparing direct and indirect forms of intergroup contact in Cyprus
Keywords: attitudes
imagined contact
intergroup contact
direct contact
vicarious contact

This thesis examines and compares the effectiveness of direct and indirect types of contact in leading to short- or longer-term prejudice-reducing outcomes in Cyprus. Chapter 1 provides a background to the relations between Greek and Turkish Cypriots and Chapter 2 provides a theoretical introduction to the intergroup contact hypothesis (Allport, 1954) and to extended friendships (Wright, Aron, McLaughlin-Volpe, & Ropp, 1997), vicarious contact (Mazziotta, Mummendey, & Wright, 2011), and imagined contact (Crisp & Turner, 2009) which have been suggested to be alternatives and a stepping stone to direct contact when the latter is absent. Chapter 3 consists of three experiments assessing the relative effects of direct and vicarious contact (Experiments 1 and 2) and imagined contact (Experiment 3). The results show that direct, and to a weaker extent, vicarious contact lead to more positive outgroup attitudes, but that a week after contact this effect is lost. All types of contact yield less anxiety, an effect that endures in time, and direct and imagined contact yield more positive action tendencies, an effect that remains significant in time only for direct contact. Chapter 4 consists of two experiments further exploring the capacity of imagined contact to yield positive intergroup outcomes. Experiment 4 tests whether the induction of interpersonal and intergroup similarities and/or differences into a positive imagined contact scenario affects participants evaluation of the outgroup. The results show, in line with the Optimal Distinctiveness Theory (Brewer, 1971), that ‘balanced similarity’ which incorporates both similarities and differences yields more positive outgroup attitudes than the conditions focusing only on similarities or only on differences. Experiment 5 compares ‘balanced similarity’ with positive imagined contact and finds that only the former affects variables related to preparing individuals for future contact. Chapter 5 consists of a three-wave longitudinal study examining the temporal effects of direct and extended friendships on outgroup attitudes and their mediation. Both types of friendships yield a significant indirect effect on attitudes which is stronger for direct friendships and is mediated by intergroup anxiety for both types of friendships and also by ingroup norms for direct friendships. Chapter 6 presents and discusses the key findings, outlines the limitations of these studies, and suggests avenues for future research.
High contrast limitations of slicer based integral field spectrographs
Keywords: High Contrast
Integral Field Spectrograph
Direct Detection
Slicer IFS
Speckle Noise
Spectral Deconvolution
Exoplanet

The viability of using a slicer based integral field spectrograph (IFS) for high contrast observations has been under scrutiny due to the belief that the one dimensional coherence that persists along the slice to the point of sampling at the detector will cause the creation of secondary speckles that will not have the same characteristics as normal speckles, thus stopping us from calibrating them out. It has also been previously assumed that a suitably low differential wavefront error when moving slice to slice was not guaranteed by design. It was for these reasons that slicer based IFSs were not selected for the current generation of planet finding instruments. As part of the EPICS (Exo Planet Imaging Camera and Spectrograph for the E-ELT) design study it was decided that slicers should be re-investigated due to results from on sky observations suggesting these limitations did not exist.
The purpose of this thesis was to determine whether there was validity to the concerns mentioned above and therefore to answer the question; Would implementing a slicer based integral field spectrograph limit the achievable contrast of an instrument designed for the direct detection of exoplanets? Chapter 1 gives a brief introduction into the field of exoplanet research. Charpter 2 describes the noise limiting direct detection of exoplanets and the ways to get around it. Chapter 3 gives an overview of the two types of IFS under investigation by the EPICS consortium. Chapter 4 looks into details of the EPICS instrument and the IFS design study that came about. Chapter 5 shows simulations performed for the aim of achieving better contrasts via post processing methods and accurate data reduction as well as simulations of slicer based integral field spectrographs. Experimental tests using a slicer and a preoptics setup designed to simulate the limiting noise are described in Chapter 6. Chapter 7 looks at using SINFONI for high contrast observations and Chapter 8 details the conclusions drawn from the work presented in this thesis, as well as possible extensions to it.
The work performed in this thesis dispels the concerns about the continued one dimensional coherence up to the detecter and suggests that slicer based integral field spectrographs do not inherently limit the contrast achievable; Results from experiments fit well with the requirements for EPICS to achieve its goals. Simulations also supported the idea that secondary speckle noise should not be an issue for the slicer based IFS. This means that a slicer based IFS is a viable option for the EPICS instrument.
e-Research in the life sciences: from invisible to virtual colleges
Keywords: sociology of science
internet
social media

e-Research in the Life Sciences examines the use of online tools in the life sciences and finds that their use has significant impact, namely the formation of a Scientific/Intellectual Movement (SIM) (Frickel & Gross, 2005) complemented by a Computerisation Movement (CM) (Kling & Iacono, 1994) which is mobilising global electronic resources to form visible colleges of life science researchers, who are enrolling others and successfully promoting their open science goals via mainstream scientific literature. Those within this movement are also using these online tools to change their work practices, producing scientific knowledge in a highly networked and distributed group which has less regard for traditional institutional and disciplinary boundaries. This thesis, by combining ideas about SIMs and CMs, fills a gap in research that is typically confined to treating new tools as a part of scientific communication or in specialist areas like distributed collaboration but not in terms of broader changes in science.
Case studies have been conducted for three types of online tools: the scientific social networking tool FriendFeed, open laboratory notebooks, and science blogs. Data have been collected from semi-structured interviews, and the online writings of research participants. The case studies of exemplary use by scientists of the web form a baseline for future studies in the area.
Boundaries between formal and informal scholarly communication are now blurred. At the formal level, which peer-reviewed print journals continue, many academic publishers now also have online open access, frequently in advance of print publication. At the informal level, what used to be confined to water-cooler chat and the conference circuit is now also discussed on mailing lists, forums and blogs (Borgman, 2007). As these online tools generate new practices they have potential to affect future academic assessment and dissemination practices.
Efficient numerical modelling of wave-structure interaction
Keywords: ocean waves
BEM
fluid mechanics

Offshore structures are required to survive in extreme wave environments. Historically, the design of these offshore structures and vessels has relied on wave-tank experiments and linear theory. Today, with advances in computing power, it is becoming feasible to supplement these methods of analysis with fully nonlinear numerical simulation.
This thesis is concerned with the development of an efficient method to perform this numerical modelling, in the context of potential flow theory. The interaction of a steep ocean wave with a floating body involves a moving free surface and a wide range of length scales. Attempts to reduce the size of the simulation domain cause problems with wave reflection from the domain edge and with the accurate creation of incident waves.
A method of controlling the wave field around a structure is presented. The ability to effectively damp an outgoing wave in a very short distance is demonstrated. Steep incident waves are generated without the requirement for the wave to evolve over a large time or distance before interaction with the body. This enables a general wave-structure interaction problem to be modelled in a small tank, and behave as if it were surrounded by a large expanse of water.
The suitability of the boundary element method for performing this modelling is analysed. Potential improvements are presented with respect to accuracy, robustness, and computational complexity. Evidence of third order diffraction is found for an FPSO model.
An exploration of sight, and its relationship with reality, in literature from both world wars
Keywords: sight
world war one literature
eye sight
world war two literature

Writers from both world wars, concerned with the representation of war, wrestled with the predicament of partial sight. Their work reveals the problematic dichotomy that exists between the individual’s selective range of vision and the immense scale of conflict. Central to this authorial dilemma is the question of the visual frame: how do you contain – within the written word – sight that resists containment and expression? The scale of the two world wars accentuated the representative problem of warfare. This thesis, by examining a wide range of World War One and World War Two literature, explores the varied literary responses to the topical relationship between sight and reality in wartime. It examines the war poetry of Wilfred Owen, Ford Madox Ford’s tetralogy Parade’s End, The Return of the Soldier by Rebecca West, Elizabeth Bowen’s The Heat of the Day, and Virginia Woolf’s novels Mrs Dalloway and Between the Acts alongside less well-known works such as David Jones’s prose-poem In Parenthesis, the two short stories ‘The Soldier Looks for His Family’ by John Prebble and ‘The Blind Man’ by D.H. Lawrence, as well as William Sansom’s collection of short stories Fireman Flower, and Louis Simpson’s war poetry. This thesis, by focussing on the inherent difficulties of reconciling perception and representation in war, interrogates the boundaries of sight and the limits of representation. The changing place of sight in writing from the two world wars is examined and the extent to which discourses of vision were shaped and developed, in the early decades of the twentieth century, by war experience is explored. The critical containment and categorisation of sight that often dominates readings of sight in texts from both world wars is questioned suggesting the need for a more flexible understanding of, and approach towards, sight.
Psychological agency in a neighbourhood on the urban fringe of Bamako
Keywords: Empowerment
Agency
Mali
Social Change

This thesis is about psychological constructions underpinning intentional action to improve well-being by people in a neighbourhood on the urban fringe of Bamako, Mali. There is a large deficit in the theorisation of psychological elements of agency and empowerment in the development literature. Instead empowerment is generally defined as a favourable opportunity structure, as choice or as the distribution of power. Further still, the examination of the psychological literature reveals a lack of empirical research related to non-Western contexts and development policy. In view of this, I present the results of an empirical study using the inductive mixed methods to examine the central factors contributing to initiatives people undertake to improve personal and collective well-being. Informants articulated that the psychological concepts of dusu (internal motivation) and ka da I yèrè la (self-efficacy) were most important to their purposeful agency. The empirical analysis is divided into three parts and based primarily on qualitative data, enriched by quantitative analysis. Firstly I will examine the concepts of dusu and ka da I yèrè la, which are characterised as having an instrumental and intrinsic significance to people’s purposeful agency. They were also characterised as important factors in supporting local social development initiatives. Secondly, I will show how these psychological concepts were not related to the agent’s socio-economic characteristics or decision making ability, rendering both variables weak proxies for measuring psychological agency. Instead I found that measures of intrinsic motivation and self-efficacy are more viable for evaluating psychological agency. Thirdly, however, whilst dusu and ka da I yèrè la are important to people’s agency and the social development of the neighbourhood, they cannot be viewed as a silver bullet to social development in Kalabankoro Nerekoro. Specifically, in the examination of collective purposeful agency in group work (associations), the functioning of groups is impacted by the internal dynamics within the group, causing sometimes breakdown of the group. Further still, gender and age norms as well as capability deprivation and conflicting world views all thwart the ability of associations to achieve their goals. I underline that agents cannot always succeed in the pursuit of their well-being goals, even though they demonstrate high levels of psychological agency unless structural inequality at the micro, meso and macro levels of Malian society are addressed. Through this empirical study, this thesis will contribute the closing of the gap between psychological and development literatures as well as work towards developing measures of psychological agency.