VictorJuiz/thesis huggingface dataset:
Implementing Preventive Education about HIV/AIDS through Physical Education in Zambia: The Response of Teachers
Keywords: HIV
AIDS
Physical Education
Zambia
Teachers
Preventive Education
Sport for Development
Implementation
Education
Policy
Decree

Governments, United Nations (UN) agencies and international and local non-governmental organizations (NGOs) have mounted a concerted effort to remobilize sport as a vehicle for broad, sustainable social development. This resonates with the call by the UN Inter-agency Task Force for sport to be a key component in national and international development objectives. Missing in these efforts is an explicit focus on physical education within state schools, which still enroll most children in the global South. This study focuses on research into one of the few instances where physical education within the national curriculum is being revitalized as part of this growing interest in leveraging the appeal of sport and play as a means to address social development challenges such as HIV/AIDS. The study examines the response to the Zambian government’s 2006 Declaration of Mandatory Physical Education (with a preventive education focus on HIV/AIDS) by personnel charged with its implementation. The decree directed personnel to immediately begin implementing the teaching of physical education in all Basic and Secondary schools in Zambia to “ensure physical fitness and the enhancement of values, skills and holistic development of the learner” (Ministry of Education, 2006). The study examined the response of 17 teachers and education administrators from Lusaka province, Zambia. The interviews were conducted between September and December 2009. The purpose of the study was to: 1) evaluate the implementation of the Presidential Decree on physical education as a strategy for addressing HIV/AIDS through Physical Education and Traditional Zambian Games; 2) explore and understand the response of teachers and administrators to the implementation of the 2006 Presidential Decree on physical education; 3) explore how the school context influences the implementation of the Presidential Decree; and 4) map a critical path of key personnel and their resource requirements, and make recommendations for strengthening the effectiveness of HIV prevention education. Drawing on education policy implementation literature, this study provides an analysis of the rising influence of the sport for development movement and of the ways in which physical education and sport may address HIV/AIDS within national education in Zambia. The findings of the study reveal promising signs for the potential of physical education, and of particularly traditional games, for student engagement and for addressing HIV/AIDS. Yet these promising signs are undermined by poor planning and support from the education bureaucracy, deficiencies that stem from years of neglect of, until recently, non-examinable subjects such as physical education. The findings confirm that the literature on education policy implementation drawn mostly from the global North is just as applicable to education sectors in the global South.
Strengthening Mechanisms in Microtruss Metals
Keywords: microtruss
strengthening
copper
C11000
aluminum
AA2024
cellular
metal
mechanical
properties
compressive strength
densification energy
modulus
work hardening
precipitation hardening
heat treatment
nanocrystalline coating
aluminum oxide coating
coating
anodizing
electrodeposition
strengthening mechanisms
geometry
pyramidal
compression
buckling
architecture
truss
uniaxial compression
perforation
Ramberg-Osgood
Holloman
nickel-iron
annealing
relative density
periodic cellular
hybrid
composite
microhardness
stretch bend
peak strength
scanning electron microscopy
stress
strain
bending
stretching
failure
yielding
column
critical buckling strength
critical buckling stress
yield strength
forming

Microtrusses are hybrid materials composed of a three-dimensional array of struts capable of efficiently transmitting an externally applied load. The strut connectivity of microtrusses enables them to behave in a stretch-dominated fashion, allowing higher specific strength and stiffness values to be reached than conventional metal foams. While much attention has been given to the optimization of microtruss architectures, little attention has been given to the strengthening mechanisms inside the materials that make up this architecture. This thesis examines strengthening mechanisms in aluminum alloy and copper alloy microtruss systems with and without a reinforcing structural coating. C11000 microtrusses were stretch-bend fabricated for the first time; varying internal truss angles were selected in order to study the accumulating effects of plastic deformation and it was found that the mechanical performance was significantly enhanced in the presence of work hardening with the peak strength increasing by a factor of three. The C11000 microtrusses could also be significantly reinforced with sleeves of electrodeposited nanocrystalline Ni-53wt%Fe. It was found that the strength increase from work hardening and electrodeposition were additive over the range of structures considered. The AA2024 system allowed the contribution of work hardening, precipitation hardening, and hard anodizing to be considered as interacting strengthening mechanisms. Because of the lower formability of AA2024 compared to C11000, several different perforation geometries in the starting sheet were considered in order to more effectively distribute the plastic strain during stretch-bend fabrication. A T8 condition was selected over a T6 condition because it was shown that the plastic deformation induced during the final step was sufficient to enhance precipitation kinetics allowing higher strengths to be reached, while at the same time eliminating one annealing treatment. When hard anodizing treatments were conducted on O-temper and T8 temper AA2024 truss cores, the strength increase was different for different architectures, but was nearly the same for the two parent material tempers. Finally, the question of how much microtruss strengthening can be obtained for a given amount of parent metal strengthening was addressed by examining the interaction of material and geometric parameters in a model system.
Reversible Oxidative Addition in Palladium Catalysis: New Methods for Carbon–Carbon and Carbon–Heteroatom Bond Formation
Keywords: palladium catalysis
heterocycles
copper
alkene functionalization

The development of new, improved methods for forming carbon–carbon and carbon–heteroatom bonds is the basic goal in synthetic organic chemistry. In the Lautens group, many recent advances have been made using late transition metals such as rhodium and palladium. One such research project involves the synthesis of indoles through tandem C–N and C–C coupling reactions using gem-dibromoolefin starting materials, and this area serves as a starting point for the research described. Chapter 1 describes a method by which the tandem use of gem-dibromoolefins can be halted to give intramolecular monocoupling reactions, maintaining one of the carbon–bromine bonds which can serve as a useful handle for further functionalization. The use of copper as a catalyst is key to this reaction, as it features a unique mechanism for carbon–heteroatom bond formation. Benzofurans and benzothiophenes can be prepared by this method. Chapter 2 describes the synthesis of 2-bromoindoles using an intramolecular Buchwald–Hartwig amination of gem-dibromoolefins. It is found that the products are more reactive towards palladium(0) than the starting material, and the use of a bulky phosphine ligand which facilitates reversible oxidative addition is required. This represents one of the first catalytic applications of this step in synthesis. Chapter 3 further explores the concept of reversible oxidative addition in a novel carbohalogenation reaction of alkenes. Aryl iodides tethered to alkenes are treated with a palladium(0) catalysts, which can undergo the basic steps of oxidative addition, carbopalladation, and novel sp2 carbon–iodine reductive elimination. This process is remarkably simple in concept, and is a waste-free, atom economically method for preparing new carbon–carbon bonds. Chapter 4 discusses various limitations to the carbohalogenation methodology, and seeks to overcome these problems. The use of aryl bromide starting materials can be accomplished by adding an iodide source to the reaction, allowing halide exchange of palladium(II) intermediates to occur. Intermolecular and asymmetric variants are also explored. Computational studies are discussed which reveal useful mechanistic details of the catalytic cycle, and this information is used in the development of novel phosphine ligands.
The Exploration of Critical Care Nurses' Use of Accumulated knowledge and Information-seeking for Non-routine Tasks
Keywords: Information-seeking
Critical care nurses
Problem-solving ability
non-routine tasks

Background Nurses complete tasks during patient care to promote the recovery, or to maintain the health, of patients. These tasks can be routine or non-routine to the nurse. Non-routine tasks are characterized by unfamiliarity, requiring nurses to seek additional information from a variety of sources to effectively complete the tasks. Nurses’ perception of their problem-solving skills, as characterized by the attributes of personal control, problem-solving confidence, and avoidance-approach style, influences how information is sought. Objectives/Research Questions Guided by the information-seeking behaviour model, this study was designed to: (1) examine how the non-routineness of the task affects nurses’ information-seeking behaviour and the use of accumulated knowledge; and, (2) explore nurses’ perception of their problem-solving abilities. Methods An exploratory cross-sectional survey design was used. A random sample of critical care nurses who worked in a hospital setting were selected from the College of Nurses of Ontario (CNO) research participant database. Multiple regression analysis was used to examine the proposed relationships. Results Avoidance-approach style and, problem-solving confidence did not have a significant relationship with nurses’ information-seeking behaviour. None of the variables explained use of accumulated knowledge (F = 0.902, p > 0.05). Previous training (p = 0.008), Non-routineness of the task (p = 0.018), and Personal control (p = 0.040) had a positive relationship with information-seeking behaviour (Adjusted R2 = 0.136). Implications The study results provide evidence that problem-solving ability, and in particular the attribute of personal control, influences nurses’ information-seeking behaviour during the completion of nursing tasks. They reveal how information is sought from resources, and what specific information resources are necessary to promote access to, and use of, evidence-based information. The results also help direct efforts towards training nurses in issues related to problem-solving and information-seeking by targeting the development of personal control and retrieving evidence-based information.
The Activation of Small Molecules Employing Main Group and Transition Metal Frustrated Lewis Pairs
Keywords: Frustrated Lewis Pairs
Small Molecule Activation

Combinations of sterically encumbered Lewis acids and Lewis bases are precluded from dative bond formation, failing to yield classical Lewis acid-base adducts. These unique systems are referred to as frustrated Lewis pairs (FLPs) and demonstrate a plethora of unique small molecule activations.Herein, the syntheses of phosphonium alkoxy- and aryloxyborate salts in addition to phosphonium thioborate salts are detailed. The scope of Lewis acid and base, alcohol and thiol, that are effective in this chemistry, is also detailed. The syntheses of novel borate and boronate esters of the form B(OR)3 and (C6R4O2)B(C6F5) are detailed and applied in metal-free heterolytic dihydrogen activation with phosphines. The further study of a variety of perfluoroboranes in the activation of H2 with tertiary phosphines is also detailed. Derivatization of triarylboranes, boronate esters, borinic esters and chloroboranes by reaction with one or two equivalents of alky- or aryldiazomethane is achieved yielding the corresponding RR’C insertion products. The solid-state structures of the free boranes, in addition to Lewis base adducts of a sampling of these species, are detailed. Reactivity of the resulting sterically encumbered boranes in imine hydrogenations, H2 and XeF2 activation are also detailed. Combinations of intermolecular frustrated Lewis pairs are found to react collaboratively to activate greenhouse gases such as carbon dioxide (CO2) and nitrous oxide (N2O), yielding the corresponding zwitterionic compounds R3P(CO2)BR2R’ and R3P(N2O)BR’3. Atom connectivity has been established via X-ray crystallographic studies and molecular structures and parameters are discussed. Subsequent exchange chemistry of both CO2 and N2O species with transition metal and other d-block Lewis acids are investigated and yield zwitterionic compounds and ion pairs which are otherwise unobtainable employing more conventional methods. Transition metal containing Lewis acids are employed in conjunction with tri(tert-butyl)phosphine for the FLP-mediated direct activation of N2O.
Improving Executive Functioning in Children with Fetal Alcohol Spectrum Disorders using the Alert Program for Self Regulation®
Keywords: Fetal Alcohol Spectrum Disorders
Intervention

The chronic and severe executive functioning (EF) and self regulation deficits experienced by children with fetal alcohol spectrum disorders (FASD) are well documented and EF and self regulation have been identified as core targets for intervention. The goals of this dissertation were to: (i) examine the effects of a self regulation treatment for children with FASD on a range of EF measures (ii) examine neural markers of treatment outcome and determine if functional magnetic resonance imaging (fMRI) can differentiate treatment responders from nonresponders; (iii) determine if treatment effects generalize to child compliance and qualitatively examine the treatment process. Twenty-five children with FASD participated. Using a wait-list control design children were assigned to an immediate treatment (TXT; n = 12) or delayed treatment control (DTC; n = 13) condition. All children received an evaluation of EF and fMRI at baseline and 12-week follow-up. Parents also completed questionnaires assessing EF and behavior as well as a feedback questionnaire upon completion of treatment. A subset of parents tracked compliance over the course of their child’s therapy. For the TXT group only, parent questionnaires were readministered at 6 month follow-up. At 12-week follow-up, children in the TXT group displayed significant improvements in inhibitory control and social cognition. Additionally, parents reported improved behavioral and emotional regulation. This improvement, along with a further improvement in parent-rated inhibitory control, was maintained at the 6-month follow-up. Neuroplastic changes were also observed as the TXT group showed increased BOLD response in the right prefrontal cortex (PFC) and left caudate on a task of inhibitory control. When treatment responders were compared to nonresponders a pattern of increased BOLD response was found bilaterally in the PFC and left caudate. Compliance tracking revealed that self regulation therapy generalized to improved child compliance at home. Qualitative analysis indicated that perceived clinician competence, caregiver insight about child’s problems and caregiver perceptions of child’s insight about their problems, were the most commonly endorsed themes by caregivers. Results from this research signify that children with FASD are responsive to psychotherapy and following a brief intervention, showed improvements in self regulatory abilities that generalize to other EF areas and parent-reported behaviors.
A Life of One’s Own: Freedom and Obligation in the Novels of Henry James
Keywords: private law
Henry James
law and literature
private law theory

This dissertation argues that the novels of Henry James offer a conception of personhood and of human freedom better able to explain and unify private law than the conceptions currently dominant in private law theory. I begin by laying out the two conceptual frameworks that now dominate private law theory: Kantian right and the feminist ethic of care. I argue that Kantian right‟s exclusive focus on respect for freedom of choice makes it unable to explain private law doctrines founded upon concern for human well-being, including unjust enrichment, unconscionability, and liability for negligence. However, feminism‟s ethic of care, which can be understood as a response to the Kantian abstraction from considerations of well-being and need, is also incomplete, because its understanding of the person as essentially connected to others fails to respect human separateness. I then offer readings of James‟ novels—The Portrait of a Lady, What Maisie Knew, and The Ambassadors—that show how vindicating individual worth requires both respect for abstract agency‟s separateness and freedom to choose, on the one hand, and concern for the dependent individual‟s well-being and autonomous flourishing, on the other. I argue that these two ideas are complementary parts of a complete understanding of human dignity and freedom. Finally, I argue that this understanding illuminates doctrines of private law that remain mysterious on the Kantian account while avoiding feminism‟s tendency to immerse private law in public law.
A Study of Classroom Teachers' Experiences in a Collaborative Learning Community: Learning to Improve Support for Students with characteristics of ADHD and their Literacy Learning
Keywords: Professional Development
ADHD
Collaborative Learning Communities
Literacy
Professional Learning
Inattention
Hyperactivity
Teaching Strategies
Teaching
Elementary
Teacher Training

This research investigated elementary classroom teachers' experiences in a collaborative learning community (CLC) on the topic of supporting the literacy learning of students with characteristics of ADHD. Five general education classroom teachers participated in biweekly CLC meetings over a 5-month period. Qualitative methods of data gathering were employed in the form of participant observations in the classroom and during 9 CLC meetings. Participants were also interviewed three times. The first interview was conducted before the CLC meetings began, the second interview was conducted immediately after formal CLC meetings had ceased, and the final interview was conducted 6 months after meetings had ended. Three main findings emerged from the research. First, participants' literacy teaching of their students with characteristics of ADHD was positively influenced as a result of their participation in the CLC. This positive influence came through an interaction of factors related to their knowledge, skills, attitudes, and beliefs. It also resulted from a reconceptualization of both their understanding of their students with characteristics of ADHD and of themselves as literacy teachers. Second, certain aspects of the CLC contributed to this positive outcome. These aspects were the opportunity to work with colleagues, participant control over the format and content of CLC, and repeated opportunities to reflect on and refine teaching practice. Third, personal and contextual factors shaped the participants' experiences within the CLC. Participants who had challenges during their own schooling were more driven and committed to understand and respond to their students’ diverse learning needs. Participants with the most number of years of teaching experience had a more fully realized skill set, higher levels of self-efficacy, and lower levels of stress related to teaching and meeting the needs of their students with characteristics of ADHD. Implications for school literacy teaching, preservice education, in-service education, and future avenues for research are discussed in light of the findings.
Structural Basis for Misfolding at Disease Phenotypic Positions in CFTR
Keywords: cystic fibrosis
CFTR
membrane protein
protein folding

Misfolding of membrane proteins as a result of mutations that disrupt their functions in substrate transport across the membrane or signal transduction is the cause of many significant human diseases. Yet, we still have a limited understanding of the direct consequences of these mutations on folding and function - a necessary step toward the rational design of corrective therapeutics. This thesis addresses the gap in understanding the residue-specific implications for folding through a series of experiments that utilize the cystic fibrosis transmembrane conductance regulator (CFTR) as a model in various contexts. We first examined the thermodynamic implications of mutations in the soluble nucleotide binding domain 1 (NBD1) of CFTR. We found that mutations can have a significant effect on thermodynamic stability that is masked in non-physiological conditions. Our studies were then focussed on a membrane-embedded hairpin CFTR fragment comprised of transmembrane segments 3 (TM3) and 4 (TM4) to evaluate the direct effects of mutations on folding in a systematic manner. It was found that the translocon-mediated membrane insertion of helices closely parallels a basic hydrophobic-aqueous partitioning event. This study was then extended to determine residue-specific effects on helix-helix association. We found that this process is not solely dependent on hydropathy, but there is a context dependence of these results with regard to residue position within the helix. Overall, these findings constitute a key step in relating mutation-derived effects on membrane protein folding to the underlying basis of human disease such as cystic fibrosis.
Structural Brain Abnormalities in Temporomandibular Disorders
Keywords: MRI
Pain
Temporomandibular disorder
Chronic Pain
Brain
Plasticity
Voxel-based morphometry
Cortical thickness analysis
Diffusion tensor imaging
brain
white matter
gray matter
trigeminal
age

Temporomandibular disorders (TMD) are a family of prevalent chronic pain disorders affecting masticatory muscles and/or the temporomandibular joint. There is no unequivocally recognized peripheral aetiology for idiopathic TMD. The central nervous system (CNS) may initiate and/or maintain the pain in idiopathic TMD due to sustained or long-term nociceptive input that induces maladaptive brain plasticity, and/or to inherent personality-related factors that may reduce the brain's capacity to modulate nociceptive activity. The main aim of this thesis is to determine whether there are structural neural abnormalities in patients with TMD, and whether these abnormalities are related to TMD pain characteristics, or to neuroticism. The specific aims are to delineate in TMD: (1) gray matter (GM) brain abnormalities and the contribution of pain and neuroticism to abnormalities; (2) the contribution of abnormal brain GM aging in focal cortical regions associated with nociceptive processes; and (3) abnormalities in brain white matter and trigeminal nerve and the contribution of pain. In groups of 17 female patients with TMD and 17 age- and sex- matched controls, magnetic resonance imaging revealed that patients with TMD had: (1) thicker cortex in the somatosensory, ventrolateral prefrontal and frontal polar cortices than controls, (2) cortical thickness in motor and cognitive areas that was negatively related to pain intensity, orbitofrontal cortical thickness that was negatively correlated to pain unpleasantness, and thalamic GM volume correlated to TMD duration, (3) an abnormal relationship between neuroticism and orbitofrontal cortical thickness, (4) abnormal GM aging in nociceptive, modulatory and motor areas, (5) widespread abnormalities in white matter tracts in the brain related to sensory, motor and cognitive functions, (6) reduced trigeminal nerve integrity related to pain duration, and (7) abnormal connectivity in cognitive and modulatory brain regions. In sum, this thesis demonstrates for the first time abnormalities in both peripheral nerve and CNS in patients with TMD.