VictorJuiz/thesis huggingface dataset:
Moral theological method in the theological ethics of Martin Luther and Arthur Rich, with particular reference to their economic ethics
Keywords: christian ethics
ethics
economic ethics
Martin Luther
Arthur Rich

This thesis seeks to expand the self-critical resources of contemporary theological economic ethics by bringing the method of a pre-modern theologian and social commentator, Martin Luther (1483-1546), into interaction with that of a modern contribution to social ethics, the Swiss theologian Arthur Rich (1910-92). This thesis is the first substantial treatment in English of Rich’s magnum opus, Wirtschaftsethik. The demonstration of the thesis is undertaken by a close engagement with a selected publication of Luther (his 1519/20 Großer Sermon von dem Wucher) and of Rich (his masterwork, Wirtschaftsethik, published in two volumes in 1984 and 1990 respectively). The thesis does not simply describe Luther’s and Rich’s economic ethics, but demonstrates the way in which they operate, that is, their method.
An introduction sets out the thesis, and defends its method. Chapter 1 introduces Luther’s sermon on usury, and situates it in its context. It then gives a commentary on Luther’s method, discussing its genre, the way in which Luther deploys Scripture and exploits doctrines with respect to ethics, and his concept of the twofold government of God. It analyses how Luther brings these theological motifs to bear on a particular economic question. Chapter 2 sketches Arthur Rich’s life and work, and presents Rich������s method as set out in Wirtschaftsethik. It discusses his understanding of ethics, his approach to Scripture, and his adoption of the thought of Max Weber and John Rawls. Chapter 3 brings our study of Luther to bear on Rich’s approach, noting strengths and weaknesses of Rich’s method. It questions some of Rich’s assumptions, and notes ways in which a more self-critical approach could have made his project more successful. A conclusion then summarises the argument, and makes tentative suggestions as to the wider applicability of the critical questions posed to Rich’s method by the analysis of Luther.
Design and synthesis of inositol phosphate-based probes
Keywords: Inositol
Inositol Pyrophosphate
Inositol Phosphate
Protein Kinase B
Organic Synthesis

Inositol phosphates play a fundamental role in many intracellular processes. Of particular importance is the role of phosphatidylinositol 3,4,5-trisphosphate [PtdIns(3,4,5)P3] in the protein kinase B (PKB/Akt) signalling pathway. PtdIns(3,4,5)P3 recruits PKB to the cell membrane through binding interactions with its pleckstrin homology (PH) domain. In several human cancers, this signalling pathway is upregulated, resulting in increased cell growth and proliferation. In order to investigate the therapeutic potential of the PtdIns(3,4,5)P3–PH domain binding interaction, it is necessary to develop inositol phosphate-based probes.
This DPhil dissertation highlights the synthesis of a number of derivatives of the PtdIns(3,4,5)P3 head group – inositol 1,3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4]. These derivatives incorporated phosphate isosteres at both the 3- and 5-positions of Ins(1,3,4,5)P4, through the utilisation of novel protection and deprotection strategies. In addition, this dissertation highlights the efficient synthesis of the natural product inositol 1,3-bisphosphate [Ins(1,3)P2] and our work towards the synthesis of inositol pyrophosphate derivatives.
Familiar collaboration and women writers in eighteenth-century Britain: Elizabeth Griffith, Sarah Fielding and Susannah and Margaret Minifie
Keywords: sociability
criticism
collaboration
women

Between 1740 and 1770, a number of women writers choose to make explicit in their printed texts their collaboration with a ‘familiar’: a family member or close friend. In so doing, they strategically enact their personal relationships through the medium of print in order to claim for themselves a level of literary power and delineate the terms on which they entered the marketplace as authors. This thesis argues that familiar relations expressed along a horizontal axis – those of husband, wife, brother, sister and friend – offer a relatively flexible model of familiar relations in which women could acquire a level of agency in self-definition, supported by ideologies that valued women’s contribution to the polite sphere of sociable conversation. It demonstrates that Elizabeth Griffith, Sarah Fielding, Jane Collier, and Susannah and Margaret Minifie not only engage in collaborative literary production that is thoroughly inflected with the pressures of their historical context but that through familiar collaboration women writers display their professional authorial personae and generate social and literary criticism. Through close readings of carefully selected collaborative texts in the corpus of each writer, including the material history of the texts themselves, and the relationships expressed through those texts, this thesis highlights the complexity with which family relations interacted with print culture in the period. Far from using the familiar relation as a means of modestly retiring to the domestic sphere these women writers used their familiar relations as a basis from which to launch, describe and defend their authorial careers.
Social networks, community-based development and empirical methodologies
Keywords: Ethiopia
political connections
targeting effectiveness
PAPI
peer effects
local government
awareness
bias
Social networks
CAPI
data quality
exclusion bias
Tanzania
food aid
consumption measurement
community-based development
information spread

This thesis consists of two parts: Part I (Chapters 2 and 3) critically assesses a set of methodological tools that are widely used in the literature and that are applied to the empirical analysis in Part II (Chapters 4 and 5).
Using a randomised experiment, the first chapter compares pen-and-paper interviewing (PAPI) with computer-assisted personal interviewing (CAPI). We observe a large error count in PAPI, which is likely to introduce sample bias. We examine the effect of PAPI consumption measurement error on poverty analysis and compare both applications in terms of interview length, costs and respondents’ perceptions.
Next, we formalise an unproven source of ordinary least squares estimation bias in standard linear-in-means peer effects models. Deriving a formula for the magnitude of the bias, we discuss its underlying parameters. We show when the bias is aggravated in models adding cluster fixed effects and how it affects inference and interpretation of estimation results. We reveal that two-stage least squares (2SLS) estimation strategies eliminate the bias and provide illustrative simulations. The results may explain some counter-intuitive findings in the social interaction literature.
We then use the linear-in-means model to estimate endogenous peer effects on the awareness of a community-based development programme of vulnerable groups in rural Tanzania. We denote the geographically nearest neighbours set as the relevant peer group in this context and employ a popular 2SLS estimation strategy on a unique spatial household dataset, collected using CAPI, to identify significant average and heterogeneous endogenous peer effects.
The final chapter investigates social network effects in decentralised food aid (free food and food for work) allocation processes in Ethiopia, in the aftermath of a serious drought. We find that food aid is responsive to need, as well as being targeted at households with less access to informal support. However, we also find strong correlations with political connections, especially in the immediate aftermath of the drought.
Characterisation of a mouse gene-phenotype network
Keywords: gene network
phenotype network
bioinformatics
biochemistry
ontology

Following advancements in the "omics" fields of molecular biology and genetics, much attention has been focused on categorising and annotating the large volume of data that has been produced since the sequencing of human and model genomes. With high-throughput data generated from these "omics" experiments and the increasing deposition of information from genetics experiments in biological databases, our understanding of the mechanisms that bridge the gap from genotype to phenotype can be explored in a holistic context. This is one of the aims of the relatively new field of systems biology, which aims to understand the complexity of biological systems in a holistic manner by studying the system as an ensemble of interacting parts. With increased volume and comprehensiveness of biological data, prediction of gene function and automatic identification of potential models for human diseases have become important aspects of systems-level analysis for wet-lab geneticists and clinicians.
Here, I describe an integrated analysis of mouse phenotype data with high-throughput experiments to give genome-wide information about gene relationships and their function in a systems biology context. I show a functional dissection of mouse gene and phenotype networks and investigate the potential that ontology-compliant phenotype annotations can offer for functional classification of genes. The mouse genome and phenome show modularity at higher levels of cellular, physiological and organismal function. Using high-throughput protein-protein interaction data, the mouse proteome was dissected and computationally extracted communities were used to predict phenotypes of mouse gene ablation. Precision and recall curves show comparable performance for higher levels of the MP ontology to those undertaken by comprehensive mouse gene function prediction such as the Mouse Function Project which predicted Gene Ontology terms. I also developed and tested an automatic procedure that relates mouse phenotypes to human diseases and demonstrate its application to the use cases of identifying mouse models given a query consisting of a set of mouse phenotypes and breaking down human diseases into mouse phenotypes.
Taken together, my results may be useful as a map for candidate gene discovery, finding how mouse networks relate to human networks and investigating the evolutionary origins of their components at higher levels of gene function.
Towards the study of cold chemical reactions using Zeeman decelerated supersonic beams
Keywords: magnetic fields
supersonic beam
hydrogen atoms
Zeeman effect
cold molecules
metastable helium

Zeeman deceleration is an experimental technique which allows for the manipulation of open-shell atoms and molecules in a supersonic beam thus producing mK-cold, velocity-tunable beams of particles in selected quantum states. The method relies on the Zeeman interaction between paramagnetic particles and time-varying, inhomogeneous magnetic fields generated by pulsing high currents through an array of solenoid coils.
This thesis describes the construction and implementation of a supersonic beam setup including a 12-stage Zeeman decelerator. The Zeeman decelerator follows an original design that makes it possible to replace individual deceleration coils. Using ground-state hydrogen atoms as a test system, it is shown that the transverse acceptance in a Zeeman decelerator can be significantly increased by generating a rather low, temporally varying quadrupole field in one of the solenoid coils.
An electron-impact source was constructed and optimised enabling, for the first time, the Zeeman deceleration of metastable helium atoms in the 23S1 state, with an up to 40 % decrease in the kinetic energy of the beam. It is shown that the pulse duration for electron-impact excitation needs to be matched to the acceptance of the decelerator in order to attain a good contrast between the decelerated and undecelerated parts of the beam.
Experimental results are rigorously analysed and interpreted using three-dimensional numerical particle trajectory simulations. A phase-space model provides, for the first time, a means to estimate the six-dimensional phase-space acceptance in a Zeeman decelerator and to find optimum parameter sets for improved Zeeman deceleration schemes. The approach also reveals a hitherto unconsidered velocity dependence of the phase stability which is ascribed mainly to the rise and fall times of the current pulses that generate the magnetic fields inside the deceleration coils.
In the future, it is planned to combine the Zeeman decelerator with a source of cold atomic and molecular ions to study chemical collisions at low temperatures. A hybrid magnetic guide consisting of permanent magnet assemblies (Halbach arrays) in hexapole configuration and a set of current-carrying wires is proposed and simulated as an interface between these setups. The design promises very efficient velocity selection, a high degree of quantum-state selection and a nearly complete removal of residual carrier gas. Prospects for using magnetic hexapole focusing in front of the Zeeman decelerator are discussed.
The work represents a major step towards the study and control of chemical reactivity of paramagnetic species in the low-temperature regime and it will help in the testing of fundamental chemical reaction theories.
Theoretical studies of underscreened Kondo physics in quantum dots
Keywords: quantum dot
Kondo physics
conductance
underscreened
Luttinger
magnetic field
numerical renormalization group

We study correlated two-level quantum impurity models coupled to a metallic conduction band in the hope of gaining insight into the physics of nanoscale quantum dot systems. We focus on the possibility of formation of a spin-1 impurity local moment which, on coupling to the band, generates an underscreened (USC) singular Fermi liquid state. By employing physical arguments and the numerical renormalization group (NRG) technique, we analyse such systems in detail examining in particular both the thermodynamic and dynamic properties, including the differential conductance.
The quantum phase transitions occurring between the USC phase and a more ordinary Fermi liquid (FL) phase are analysed in detail. They are generically found to be of Kosterlitz-Thouless type; exceptions occur along lines of high symmetry where first-order transitions are found. A `Friedel-Luttinger sum rule' is derived and, together with a generalization of Luttinger's theorem to the USC phase, is used to obtain general results for the T=0
zero-bias conductance --- it is expressed solely in terms of the number of electrons present on the impurity and applicable in both the USC and FL phases. Relatedly, dynamical signatures of the quantum phase transition show two broad classes of behaviour corresponding to the collapse of either a resonance or antiresonance in the single-particle density of states. Evidence of both of these behaviours is seen in experimental devices.
We study also the effect of a local magnetic field on both single- and two-level quantum impurities. In the former case we attempt to resolve some points of contention that remain in the literature. Specifically we show that the position of the maximum in the spin resolved density of states (and related peaks in the differential conductance) is not linear in the applied field, showing a more complicated form than a simple `Zeeman splitting'. The analytic result for the low-field asymptote is recovered. For two-level impurities we illustrate the manner in which the USC state is destroyed: due to two cancelling effects an abrupt change in the zero-bias conductance does not occur as one might expect. Comparison with experiment is made in both cases and used to interpret experimental findings in a manner contrary to previous suggestions. We find that experiments are very rarely in the limit of strong impurity-host coupling. Further, features in the differential conductance as a function of bias voltage should not be simply interpreted in terms of isolated quantum dot states. The many-body nature of such systems is crucially important to their observed properties.
Pictures of processes
Keywords: graph rewriting
quantum computing
quantum information
automated reasoning
category theory

This work is about diagrammatic languages, how they can be represented, and what they in turn can be used to represent. More specifically, it focuses on representations and applications of string diagrams. String diagrams are used to represent a collection of processes, depicted as "boxes" with multiple (typed) inputs and outputs, depicted as "wires". If we allow plugging input and output wires together, we can intuitively represent complex compositions of processes, formalised as morphisms in a monoidal category.
While string diagrams are very intuitive, existing methods for defining them rigorously rely on topological notions that do not extend naturally to automated computation. The first major contribution of this dissertation is the introduction of a discretised version of a string diagram called a string graph. String graphs form a partial adhesive category, so they can be manipulated using double-pushout graph rewriting. Furthermore, we show how string graphs modulo a rewrite system can be used to construct free symmetric traced and compact closed categories on a monoidal signature.
The second contribution is in the application of graphical languages to quantum information theory. We use a mixture of diagrammatic and algebraic techniques to prove a new classification result for strongly complementary observables. Namely, maximal sets of strongly complementary observables of dimension D must be of size no larger than 2, and are in 1-to-1 correspondence with the Abelian groups of order D. We also introduce a graphical language for multipartite entanglement and illustrate a simple graphical axiom that distinguishes the two maximally-entangled tripartite qubit states: GHZ and W. Notably, we illustrate how the algebraic structures induced by these operations correspond to the (partial) arithmetic operations of addition and multiplication on the complex projective line.
The third contribution is a description of two software tools developed in part by the author to implement much of the theoretical content described here. The first tool is Quantomatic, a desktop application for building string graphs and graphical theories, as well as performing automated graph rewriting visually. The second is QuantoCoSy, which performs fully automated, model-driven theory creation using a procedure called conjecture synthesis.
Enforcing the GNU general public licence: copyright or contract?
Keywords: Free Software
Contract
Licensing
GPL
Copyright
Open-Source Software

The GNU General Public Licence (GPL) is one of the most widely used licences in the field of Free and Open Source Software (FOSS). Principally a legal document drafted to facilitate the development, use and transfer of software, the licence also embodies a strong ideological character that seeks to challenge the paradigmatic representation of software as property. At its core, the GPL places great emphasis on the licensee’s freedom to view, use, modify and distribute a covered work. However, for all its claims to openness and freedom, the GPL functions by way of restrictions. These restrictions are primarily designed to prohibit privatisation of the work by downstream licensees, but they also restrict other forms of conduct deemed contrary to the established practices of FOSS development.
This paper asks a seemingly simple legal question, yet it is one that is deeply entangled in the ideological and strategic complexities of a field that has received little in the way of judicial clarification. The question is whether the GPL’s restrictive provisions are contractual in nature or merely property-based restrictions that act unilaterally to define the scope of the granted rights. Focusing almost exclusively on Anglo-American jurisprudence, this paper will consider a variety of licensing issues relating to formalities, the nature and scope of rights, and remedies in order to determine on which side of the property/contract divide the GPL's restrictive provisions reside, or perhaps should reside.
Electron and hadronic recoil calibration for the first measurement of the mass of the W boson by the ATLAS experiment at the Large Hadron Collider
Keywords: ATLAS
Large Hadron Collider

This thesis presents work towards the first measurement of the mass of the W boson (mW) at ATLAS at the Large Hadron Collider using √—s = 7 TeV collision data taken in 2011. The electron energy calibration is presented, including a detailed study of the linearity of the ATLAS electromagnetic calorimeter. Separately, the measurement of the W boson recoil is calibrated using Z boson events. Recoil corrections for the underlying event, pileup, recoil magnitude resolution, recoil angular resolution and recoil response mismodelling are determined, with statistical uncertainties on these corrections corresponding to an estimated uncertainty on mW of 3.9 MeV. The corrections for calorimeter non-linearity and recoil modelling improve the description of the data, though systematic biases remain. To achieve a precision commensurate with the statistics of the data, these biases will need to be understood.
Versatile synthetic strategies towards the development of novel neuroblastoma inhibitors and their analogues
Keywords: Medicinal Chemistry
Methyl Jasmonate
Oncology

The aim of this thesis was to identify and develop anti-neuroblastoma agents via two strategies. The first involves a targeted therapy approach towards the synthesis of new drug-like PTP inhibitors (Chapter 2 and 3) and the second involved devising a new versatile synthetic route to the recently established anti-tumour natural-product lead, methyl jasmonates and its analogues (Chapter 4).
From a unique proprietary screening library of 5000 drug-like compounds targeted towards PTPs, three compounds from two distinct chemical series, tetrahydroquinolines P00104 and P00341, and thiobarbituric acid P00337, were identified as PTPN22 inhibitors (IC50 = 5 μM) with moderate potency in vitro. A synthetic route to each chemical series was established and optimised and the procedure was used to synthesize a series of rationally-designed analogues for detailed structure-activity relationship (SAR) studies. The compounds were tested for PTP inhibitory activity against PTPN22 via two experimentally optimised protein assays and were tested for cytotoxicity in a number of neuroblastoma cell lines. However, none of the compounds including the resynthesized hits displayed any promising biological activity, and further investigation on these chemical series was abandoned and another strategy for developing anti-neuroblastoma agents was pursued.
During the last decade, many studies have reported the cytotoxic effects of methyl jasmonate, a plant stress hormone, against various tumours both in vitro and in vivo. As the research on the anti-tumour properties of methyl jasmonate is still at early stages, and also due to the lack of a versatile synthetic procedure for the preparation of its structural derivatives, detailed SAR studies of this compound have not yet been conducted. In the course of this project, a novel versatile synthetic route to methyl jasmonate and its analogues has been developed, which allows substituents to be readily introduced at the α- and β-position of cyclopentenone. This synthetic procedure will facilitate future extensive SAR studies of methyl jasmonate in tumour cells. The cytotoxic activity of the synthesized methyl jasmonate was confirmed against a range of neuroblastoma cell lines including SK-N-SH, SHSY5Y, LAN5 and the Kelly cells, and a further study on the mechanism by which methyl jasmonate induces neuroblastoma cell death is currently underway.