VictorJuiz/thesis huggingface dataset:
'Whoever lost children lost her heart': valourised maternal grief in the Hebrew Bible
Keywords: maternal grief
Hebrew Bible
mourning rights

Recent studies on ancient Israel's mortuary culture have shown that mourning rites were not restricted to the occasions of death, burial and subsequent grief but were, in fact, implemented in diverse contexts. In this thesis I am looking at biblical traditions in which these solemn practices contributed, or sought to contribute to various forms of social restoration. More specifically, I explore the stories of biblical grieving mothers who are placed at key junctures in Israel's history to renegotiate the destinies not only of their own children, dead or lost, but also those of larger communities, i.e. family lines, ethnic groups, or entire nations. Since 'the social and ritual dimensions of mourning are intertwined and inseparable...[and] rites in general are a context for the creation and transformation of social order', these women use the circumstance of their 'interrupted' motherhood as a platform for a kind of grief-driven socio-political activism. Since maternal bereavement is generally understood as the most intense of all types of loss and was seen as archetypal of all mourning in ancient Near Eastern cultures, Israelite communities in crisis deemed sorrowing motherhood as a potent agent in bringing about their own survival and resurgence back to normalcy.
I begin my discussion on mourning rites as tools of social preservation and restoration in biblical traditions with (1) a list of modern examples that attest to a phenomenon of social, political, and religious engagement among women that stems from the circumstance of child loss; (2) a survey of recent grief and death studies that identify maternal grief as the most intense and the most enduring among other types of bereavement; (3) an overview of ancient Near Eastern cultures (Mesopotamia, Egypt, Hatti, Syro-Palestine) that not only viewed maternal grief as paradigmatic of all mourning but also utilised ritual actions performed by mothers in contexts of large scale catastrophes as mechanisms for dealing with a collective trauma. Against this background my project then turns to discuss four biblical mothers: Hagar (Gen. 21:14-21), Rizpah (2 Sam. 21:1-14), the woman of Tekoa (2 Sam. 14:1-20) and Rachel (Jer. 31:15-22), all of whom perform rites for their dying or dead children and exhibit a form of advocacy for society at large.
The biomechanics of patellofemoral pain syndrome in distance runners
Keywords: biomechanics
gait analysis
running
patellofemoral pain syndrome

Patellofemoral pain syndrome (PFPS) is the most common injury in runners. This thesis investigates the theory that prolonged eversion at the rear-foot causes prolonged tibial internal rotation and excessive femoral internal rotation, and predisposes female, distance runners to PFPS. Since eversion occurs at the subtalar joint, the morphology of the talus and calcaneus were also assessed. The study was a case-control investigation between female runners with a history of PFPS (n = 9) and normal controls (n = 10). Gait analysis was used to measure lower-limb joint angles during barefoot, treadmill running. It was hypothesised that runners with PFPS would demonstrate prolonged rearfoot eversion and tibial internal rotation, and increased hip internal rotation compared to normal controls. Computed tomography was used to image the foot and ankle in simulated weight-bearing using a custom-built loading rig. Three-dimensional models of the talus and calcaneus were generated and their shapes were quantified using principal axis lengths and orientations. The results did not support the theory that prolonged eversion and rear-foot structure predispose to PFPS during running, and attributing PFPS to these factors should be done with discretion. However, runners with a history of PFPS exhibited increased rear-foot eversion, reduced rear-foot dorsiflexion and increased knee internal rotation compared to normal controls during running, walking and squatting. Subjects with PFPS also demonstrated increased dorsiflexion at the mid-foot. It was proposed that increased eversion was secondary to reduced rear-foot dorsiflexion as this enabled compensatory dorsiflexion at the mid-tarsal complex. Due to the tight articulation of the ankle mortise, increased knee internal rotation corresponds well with excessive rear-foot eversion. A prospective study is required to establish whether these kinematic alterations are a cause or an effect of PFPS.
Modulating the immune system by amino acid depletion - IDO and beyond
Keywords: 3-dioxygenase
amino acid metabolism
Indoleamine 2
kynurenine
myeloid derived suppressor cells
tryptophan
tumour escape

Amino acid availability plays an important role in modulating the activity of T-cells. One of the pathways employed by T-cells to sense nutrient levels is the “mammalian target of rapamycin” (mTOR) pathway that is inhibited in response to nutrient depletion. Indoleamine 2,3-dioxygenase (IDO) is the first and rate-limiting enzyme along the tryptophan catabolising kynurenine pathway. T-cells are very sensitive to lack of this essential amino acid in their microenvironment and this confers strong immunomodulatory properties to cells expressing active IDO. It therefore has a significant physiological role as a homeostatic mechanism used in mammalian organisms to dampen excessive activation of the immune system but is also used as an immune evasion mechanism by many cancers.
In this study, we investigated the IDO inhibitory properties and mechanism of action of the tryptophan metabolite 3-hydroxyanthranilic acid (3-HAA) that potentially forms a negative feedback loop in the kynurenine pathway. We studied the molecule in enzymatic assays, in live cells and discovered that it inhibits IDO in an indirect way via the formation of hydrogen peroxide. Secondly, we looked at the effects of tryptophan and its metabolites on T-cell proliferation and mTOR activity, and discovered a metabolite that inhibits T-cell proliferation. Lastly we examined mechanisms of T-cell suppression employed by myeloid derived suppressor cells (MDSCs), focusing on their ability to deplete amino acids from their microenvironment. We were able to exclude tryptophan consumption as a suppressive mechanism and established that by manipulating extracellular concentrations of several amino acids other than arginine and cysteine – that are known to be utilised by MDSCs - we were able to reduce their inhibitory properties.
In summary, we have described in detail how 3-HAA inhibits IDO in in vitro assays, outlined how some tryptophan metabolites can inhibit T-cell proliferation, and clarified aspects of suppressive mechanism employed by MDSCs.
A materials chemistry investigation of archaeological lead glazes
Keywords: lead glazed ceramics
materials science
Roman pottery

In this thesis, the fabrication technology of Roman lead glazes were examined using a number of materials science techniques: namely, electron probe microanalysis, X-ray diffraction, and inductively coupled plasma atomic emission spectroscopy. The overall aim of this work was to discern particular technological styles for a wide group of lead glazes by quantifying the chemical and microstructural features of glaze production. Using experimental replication, it was found that two basic methods of glazing could be identified chemically. When applying PbO alone to an earthenware ceramic, the resulting glaze was in equilibrium with the ceramic as indicated by flat compositional profiles obtained along the glaze cross-section. However, when applying PbO·SiO2 mixtures to earthenware ceramics, gradient profiles indicative of diffusive mass transfer were obtained from the glaze cross-section. On the basis of these chemical criteria, these two methods of glazing were identified in archaeological material. It has been determined that the earliest lead glazes from Anatolia and Italy (approximately 1st century B.C.) were made using PbO·SiO2 mixtures applied to calcareous clays with Fe and Cu oxides added as colourants. Later production (post 2nd century A.D.), seems to have employed PbO alone applied to non-calcareous clays with no intentionally added colourants. The Roman production of lead glazes was compared to both those of Late Antiquity (4th – 10th centuries A.D.) which continued to use PbO applied to non-calcareous clays, and to those of Byzantine and Islamic contexts (8th – 14th centuries A.D.) which seem to have used PbO·SiO2 mixtures applied to both calcareous and non-calcareous clays. It is also argued that the technological features of the Byzantine and Islamic glaze production shared more in common with the contemporary Chinese lead glazing tradition (the Sancai wares of the 7th century A.D.) which also used PbO·SiO2 mixtures applied to non-calcareous clays, than with the Late Antique glazing tradition.
Manifesting religious belief: a matter of religious freedom, religious discrimination, or freedom of expression?
Keywords: european court of human rights
religious discrimination
human rights act
religious freedom
freedom of expression
religion
article 9
article 10

This thesis asks how manifestation of religious belief by religious individuals can best be protected in English law. It is particularly concerned with the protection available to religious individuals in the public sphere. This thesis assesses the current state of protection under religious freedom and religious discrimination models, before considering the potential for increasing protection by reconceptualising the right to manifest religious belief as an aspect of freedom of expression. This thesis asks whether the practical and conceptual limitations of a religious freedom model, and Article 9 of the European Convention on Human Rights (ECHR) in particular, can be overcome by reliance on alternative modes of protection, namely religious discrimination protections in domestic, Convention, and EU law, or through litigating religious manifestation claims as freedom of expression cases under Article 10 of the ECHR. The difficulty of communicating the harm in being denied the ability to manifest religious beliefs publicly is a key limitation of both religious freedom and religious discrimination models. Similarly, this thesis highlights the difficulty in assessing what weight should be attributed to such religious harm within a proportionality exercise balancing the rights of religious individuals with the rights and interests of other parties. The analysis in this thesis draws primarily upon the sources of law which shape domestic English law in this area, namely the ECHR and European Union law. However, this thesis also considers foreign precedent and case law from the United States in particular. This thesis contends that no one model can address the range of cases where manifestation of religious beliefs arise, and that litigants should be able to draw from religious freedom, religious discrimination, and freedom of expression protections depending on the nature of their case.
A psychological study of new age practices and beliefs
Keywords: psychology of religion
magical thinking
modern spirituality
schizotypy

This thesis consists of a study of the motivational, cognitive and personality implications of adherence to New Age practices and beliefs. The New Age, unlike traditional Western religion, possesses no church-like structure and is usually characterised as a loose network of self-development practices, with a belief system centred on the spiritual evolution of the individual through successive reincarnations and the idea of a magical interconnectedness between all things. The studies carried out used a series of psychological measures, including self-report scales, analysis of self-concepts, autobiographical episodes and attributions to life events, and experimental visual and semantic tasks. Groups of traditional religious and non-religious individuals were also assessed to serve as contrasts to the New Age group.
Following from previous sociological literature on the individualist character of the New Age, the first study dealt with individualist and collectivist motivations. New Age individuals were found to emphasise more individualistic values than Catholics, but still differed from non-religious individuals in that they stressed more self-transcendent universalism values and global-holistic self-concepts. This pattern was labelled as 'holistic individualism' and the second study sought to define it more accurately by focusing on the analysis of agency and communion motivations through the analysis of autobiographical episodes. In this study, the New Age group showed a higher frequency of agency and a lower frequency of communion themes than traditional religious and non-religious participants and, in particular, emphasised life stories of self-empowerment by non-material 'energies' or entities.
The last two studies looked more closely at the New Age tendency towards highly abstract cognitions, in particular its sense of connectedness, by focusing on magical thinking and personality traits. New Age individuals were found to attribute events to magical rather than naturalistic causes much more often than the other groups. This cognitive disposition was confirmed in the last study, which found a positive association between the adherence to New Age practices and schizotypal personality traits, emotional hypersensitivity, and cognitive-perceptual looseness. Women were also found to be keener adherents to the New Age than men.
Given this set of results, it is suggested that the New Age should be thought of primarily as a magical, rather than a religious, system of practices and beliefs. It is also proposed that an individual may be drawn to the New Age not only because of its modern individualistic appeal, but in virtue of possessing a particular personality and cognitive disposition towards magical ideation and unusual perceptual experiences.
The identity, application and legacy of Paul Hindemith’s theory of music
Keywords: Third Reich
Schenkerian Analysis
Music Theory
Paul Hindemith
Set Theory
Music Analysis

This thesis investigates the relationship between Hindemith’s music theory and his evolving compositional practice. It focuses on the first volume of his Unterweisung im Tonsatz (1937); both evaluating the very identity of the treatise and analysing how it may be applied to free composition. Above all, this work highlights the increased use of quartal pitch collections found in Hindemith’s Unterweisung-based compositions. Archival documents from the universities of Yale, Berlin, Buffalo, and the Frankfurt Hindemith Institute augment this process, and are used to revise our understanding of how Hindemith’s music theory originated, and how it relates to his practice and teaching.
The dissertation begins by exploring the theoretical and intellectual climate of the Rundfunkversuchsstelle at the Berlin Hochschule für Musik within a critical commentary of Hindemith’s music theory. It then develops a new theoretical perspective of quartal pitch space, and atonal prolongation, to provide an analytical toolkit. The list of compositions in the Unterweisung appendix, which Hindemith felt most successfully demonstrated his theory in practice, structures the next three chapters. The Sonata for Solo Viola op. 25/1, a pre-Unterweisung composition, is followed by the Ludus Tonalis, which was published soon afterwards, which is investigated for its explicit theoretical connections. The third analytical chapter focuses on the Das Marienleben cycle as a work written before the Unterweisung, and subsequently revised with theoretical concerns.
The final two chapters investigate the prominent decline in popularity experienced by Hindemith, both regarding his theory and compositions, from the 1950s. This is epitomised by a number of strongly-worded polemics published in The Music Review, much of which, it may be argued, is inaccurate or unduly critical. The thesis ends by constructing a Hindemith legacy based on a selection of archival documents and scores, together with a selection of trends in composition and music theory.
Essays on product quality, international trade and welfare
Keywords: JEL: F15
international trade
JEL: L11
JEL: L15
international economics
JEL: F12
JEL: F61
JEL: L25
industrial organisation
JEL: F14

This dissertation consists of four related, sole-authored chapters. It considers the microeconomic mechanisms for gains from trade in the presence of quality investments by firms. It shows within the framework of a quality-augmented heterogeneous firms model that the quality dimension matters for welfare gains from trade. It also provides novel empirical evidence on adjustment mechanisms of aggregate quality as a consequence of globalization. To the best of my knowledge, this is the first contribution to provide a comprehensive analysis of the role of endogenous product quality in the determination of gains from trade.
I first offer an explanation for observed industry heterogeneity in trade-induced productivity gains and show that results depend on whether or not firms have the option to invest in quality. I then take a broader view of welfare gains from trade, looking beyond productivity improvements. I find that globalization can imply a quality-variety trade-off when consumer quality preference is strong - a finding which holds under firm heterogeneity and symmetry. Nevertheless, overall gains from trade are positive. With quality being itself an important channel for gains from trade, I also investigate the detailed mechanisms by which aggregate quality changes as a consequence of globalization. This is done within the same theoretical heterogeneous firms framework as well as empirically using firm-level export data matched with firm-level quality ratings. I argue that firm heterogeneity matters for gains from trade by giving rise to an additional welfare channel in the presence of variable elasticity of demand preferences: high quality firms expand sales disproportionately in a larger market, thereby raising aggregate quality. This theoretical prediction is confirmed by the data. Furthermore, I study the mechanisms for gains from trade in a symmetric firms version of the baseline model. This allows me to isolate the role of firm heterogeneity in driving earlier results. In addition, I analyse the efficiency properties of the market equilibrium for the symmetric firms case.
Casus Belli: Giuseppe Gioachino waging war between tradition and experimentation
Keywords: dialect poetry
Sonetti romaneschi
19th Century
sonnet
Italy
Belli

This thesis explores the notion of opposition in the Sonetti romaneschi by the Roman poet Giuseppe Gioachino Belli (1791-1863). It sees the poet as a warring rebel on the literary scene and examines his poetics and rhetoric of war through his choice of form (the hallowed sonnet structure), language (the ‘rotten’ vernacular) and subject (the downtrodden, previously voiceless underclass); it shows that these cornerstones of Belli’s opus are in polemical response to literary stimuli and intimately connected to the political, religious and sociological upheavals in and beyond Rome in the troubled run-up to Unification. Chapter one, entitled ‘Breaking the mould’, draws on Belli’s explicit declaration of war on his literary predecessors, and considers the influence of the Milanese writer Carlo Porta, arguing that Belli is more inimical than amicable, and not the simple imitator as thought to date. Chapter two, ‘A passage of arms: possessing the dialogue sonnet’, maintains that the fulcrum of Belli’s antagonistic poetics and his realist enterprise lies in his unprecedented use of the dialogue sonnet form and the staging of direct debate. Chapter three, entitled ‘The Battle of the Sexes’, treats opposition at a thematic level, applying gender studies and related theory to Belli for the first time. Chapter four, ‘War and peace: the silent revolution’, examines Belli’s creation of a totally new literary language, fulfilling the criteria for what Deleuze and Guattari, within broadly Marxist parameters, would identify as a ‘minor literature’ in the work of Kafka, in which a major language is somehow wrested from its anchors of power, or ‘deterritorialized’, to subvert the literary world from within. The thesis shows that Belli is more revolutionary than previously thought as a literary innovator, and an understudied giant of modern European literature as opposed to the marginal figure the historiography is wont to maintain.
Roles of oxygenases in nucleic acid modification
Keywords: cell biology
protein chemistry
enzymology
DNA repair
medicinal chemistry
molecular biology
proteomics

2-Oxoglutarate (2OG) and Fe(II) dependent oxygenases have a broad range of substrates, extending from histones to fatty acids. Several 2OG oxygenases have nucleic acid substrates, with members of the AlkB subfamily being responsible for nucleic acid modification and repair. The AlkB protein itself is part of the Escherichia coli adaptive response, protecting the DNA from methylation damage. Methyl lesions are repaired by a direct removal mechanism via a hydroxylated intermediate, with release of formaldehyde. Homologues of AlkB have been identified throughout the vertebrates, with nine known human homologues: AlkB homologue 1-8 (ABH1-8) and Fat, mass and obesity associated protein (FTO). ABH2, ABH3 and FTO catalyse similar reactions to AlkB, whereas ABH8 methylates then hydroxylates modified wobble-position uridines in tRNA. The remaining homologues are of unknown function.
The FTO gene is associated with obesity in humans, a link confirmed by mouse models; mice lacking FTO are thinner than wildtype individuals, whereas overexpression of FTO leads to increased mass. Investigation of recombinant FTO identified a novel C terminal helical domain which appears to mediate protein dimerisation in vitro. A loss of function mutation in this C terminal domain produces a lean phenotype in mice, emphasising the importance of this domain for the protein’s function in vivo. The FTO protein was further studied in cells, and localisation of several protein variant constructs were studied by immunofluorescence. Cell lysis and immunoprecipitation techniques were developed that enable proteomic analyses of proteins with which FTO may interact in cells. No protein interactors were confidently identified, suggesting that FTO may not interact with specific proteins in cells, and instead may preferentially interact with nucleic acids.
Studies were initiated on two further members of the ABH family, ABH1 and ABH7. Recombinant proteins were prepared and characterised as 2OG oxygenases, however initial attempts to identify potential histone or nucleic acid substrates were not successful. Both proteins were found to be localised in the mitochondria, however proteomic analysis was unable to identify proteins interacting with either protein in cells.
Selective inhibitors are required for in vivo inhibition of the ABH proteins. AlkB and ABH2 proteins were purified and characterised, and a formaldehyde dehydrogenase-coupled assay was developed to follow activity of these DNA demethylases. A dynamic combinatorial mass spectrometry method was employed to identify novel inhibitor scaffolds for AlkB, leading to the successful discovery of the first series of potent and selective inhibitors for this class of enzymes. Crystal structures of AlkB in complex with the most potent compounds were obtained, rationalising the inhibition observed. This work therefore suggests that therapeutic inhibition of this family of 2OG oxygenases is likely to be tractable.