VictorJuiz/thesis huggingface dataset:
"Les Romans Mis en pièces": étude sur la Pratique de l'Adaptation Théâtrale à la fin du XIXe Siècle. Le Cas d'Émile Zola (1873-1902)
Keywords: théâtre
Zola
adaptation

Résumé Le XIXe siècle marque la consécration d’une nouvelle tendance au théâtre : la représentation de pièces tirées de romans. En France, cette pratique connaît, surtout dans la seconde moitié du siècle, une popularité sans précédent. La thèse est une étude historique de ce phénomène. La première partie situe la pratique de l’adaptation dans le contexte culturel de la deuxième moitié du XIXe siècle. La deuxième partie étudie les conditions qui entourent la production de ce type de pièce (lieux de représentation, auteurs, éditeurs). Nous nous intéressons aussi dans cette partie au discours critique et à la perception des adaptations théâtrales dans le milieu littéraire. Enfin, la troisième partie se concentre sur les adaptations théâtrales tirées des œuvres d’Émile Zola et représentées à Paris entre 1873 et 1902. Zola fut l’un des auteurs les plus adaptés sur scène au cours de cette période. En cherchant à situer l’œuvre et la participation du chef de file de l’école naturaliste dans ce phénomène théâtral, nous étudions d’abord les positions de Zola à l’égard de la pratique de l’adaptation telles qu’elles s’expriment à travers les chroniques dramatiques et les entrevues qu’il publia dans les journaux. Le deuxième chapitre de cette partie examine la production des adaptations de ses romans et de ses nouvelles représentés à la scène. Notre analyse porte, en dernier lieu, sur la réception de ces œuvres dans la presse à la fin du XIXe siècle. Enfin, nous soulignons dans la conclusion que la pratique de l’adaptation au théâtre participe au développement d’une « culture de l’image » dont le cinéma s’avère le successeur au XXe siècle.
Uncomfortable Mirrors: Religion and Mimetic Violence in Contemporary Canadian Native Literature
Keywords: Canadian Literature
Native American Studies
Native Literature
Violence
Religion and Literature
Colonialism

This study considers religion and mimetic violence in the work of four contemporary Canadian Native writers: Maria Campbell, Beatrice Culleton, Thomas King, and Basil Johnston. The mimetic violence examined is both social (the colonial attempt to remake the colonized into a reflection of the dominant culture) and personal (inter-Native conflict in which participants mirror one another in their struggle for a mutually covetted object). In order to investigate the former, I rely on the work of Homi K. Bhabha on colonial mimicry and hybridity; to examine the latter, I employ René Girard’s model of mimetic desire and violence. The principal academic contexts to this work are the study of Native literature and the academic study of religion, including the sub-field of Religion and Literature. After reviewing the relevant literature in these fields, and examining mimetic violence in key texts by the Native authors listed, I make several concluding points. First, I argue that a causal link between colonial violence and inter-Native mimetic violence is evident in the category of Native literature labelled by Thomas King as “polemical.” This includes Campbell’s Halfbreed, Culleton’s In Search of April Raintree, and King’s own Green Grass, Running Water. Second, I find that Johnston’s Moose Meat & Wild Rice and Indian School Days generally take care to separate colonial mimesis from Native mimetic conflict. This work fits King’s “associational” category of Native literature, and the disconnect evident in Johnston’s stories between the two forms of mimesis might stand as a defining feature of this category. Third, I assert that in none of the Native literature examined is religion viewed in a positive, idealist manner that assumes in its “true” manifestation it cannot be the cause of violence, which is the position taken by most religion scholars. I argue that the emphasis the Native texts place on the historic, material actions and effects of Christian individuals and institutions complements similar work being done by a minority of academics in the study of religion. Fourth, I propose possible avenues for the further investigation of mimesis in Native literature, which would use/focus on: metaphor-centred hermeneutical models; trickster figures and theories; and the conception of both Native and colonial identity. Finally, I argue that critics of Native literature have tended to idealize Native cultures, and that inter-Native mimetic violence offers a humanizing corrective to this perspective.
Behaviour of Normal and High Strength Concrete Confined with Fibre Reinforced Polymers (FRP)
Keywords: Concrete
Confinement
Stress-strain model
Fibre reinforced polymer

An extensive amount of research has been reported in previous literature on the behaviour of FRP-confined concrete subjected to concentric axial compression. However, data on the behaviour of high strength concrete confined with various types and configurations of FRP systems is still lacking and no consensus exists on the complete response of FRP-confined concrete. In addition, no appropriate design guidelines are currently available. This thesis reports results from an experimental program involving 112 cylindrical concrete specimens, 88 of which were FRP-wrapped and the remaining 24 were control specimens. All the specimens were 152 mm in diameter and 305 mm in length. Test variables included: amount of FRP materials used, strength and stiffness of FRP materials, concrete strength, and the health of concrete at the time of strengthening. Experimental results indicated that a pre-repair load of up to 77% of the unconfined concrete strength had no appreciable effect on the stress-strain response of FRP-confined concrete. With an increase of the unconfined concrete strength, the strength enhancement, energy absorption capacity, ductility factor and work (energy) index at rupture of FRP jackets all decreased remarkably. A positive correlation was found between confined concrete ductility and FRP rupture strain. In addition, a gradual post-peak failure of the specimens, observed previously from FRP-confined concrete columns tested at the University of Toronto, was also observed in some of the current tests -- owing to the high speed data acquisition system. That ductile failure can be attributed to the gradual unzipping failure of FRP jacket, which in turn is related to specimen size. A new constitutive model was developed based on material properties, force equilibrium and strain compatibility. The size effect was taken into account in the model, which is able to accommodate concrete with a wide range of strength (25 MPa to 110 MPa) confined with various types and configurations FRP systems. Design equations from CSA S806-02 and CSA S6-06 provide reasonable and conservative estimates for the FRP-confined concrete strength. To calculate the peak strain for FRP-confined concrete, an equation based on the work by Berthet et al. (2006) is proposed.
A Grounded Theory of Intensive Care Nurses’ Experiences and Responses to Uncertainty
Keywords: nurse, uncertainty, grounded theory, interviews, intensive care unit, decision making, information seeking

The purpose of this study was to develop a theory to explain how nurses experience and respond to uncertainty arising from patient care-related situations and the influence of uncertainty on their information behaviour. Strauss and Corbin’s (1998) grounded theory approach guided the study. Semi-structured face-to-face interviews were conducted with 14 staff nurses working in an adult medical-surgical intensive care unit (MSICU) at one of two participating hospitals. The grounded theory recognizing and responding to uncertainty was developed from constant comparison analysis of transcribed interview data. The theory explicates recognizing, managing, and learning from uncertainty in patient care-related situations. Recognizing uncertainty involved a complex recursive process of assessing, reflecting, questioning and/or predicting, occurring concomitantly with facing uncertain aspects of patient care situations. Together, antecedent conditions and the process of recognizing uncertainty shaped the experience of uncertainty. Two main responses to uncertainty were physiological/affective responses and strategies used to manage uncertainty. Resolved uncertainty, unresolved uncertainty, and learning from uncertainty experiences were three consequences of managing uncertainty. The ten main categories of antecedent, actions and interactions, and consequences that comprised the theory were interrelated and connected through temporal and causal statements of relationship. Nurse, patient, and contextual factors were linked through patterns of conditions and intervening relational statements. Together, these conceptual relationships formed an explanatory theory of how MSICU nurses experienced and responded to uncertainty in their practice. This theory provides understanding of how nurses think through, act and interact in patient situations for which they are uncertain, and provides insight into the nature of the processes involved in recognizing and responding to uncertainty. Study implications for practice, nursing education, and further theory development and research are discussed.
Rhetoric of Modern Jewish Ethics
Keywords: Religion
Philosophy of Religion
Ethics
Rhetoric
Jewish Ethics
Religious Ethics
Discourse Analysis

Jewish ethicists face a twofold task of persuading audiences that (a) their proposal for an issue of social concern and justice is the right and good thing to do, and (b) their proposal fits within the Judaic tradition writ large. Whereas most scholarship in the field focuses on how Jewish ethicists argue by dividing arguments into halakhic formalist, covenantalist and narrativist categories, these efforts fail both to reflect the diverse ways ethicists actually argue and to explain why they argue in these ways. My project proposes a new methodology to understand how and why Jewish ethicists argue as they do on issues of justice and concern. My project combines philosophical theology and discourse analysis. The first examines an ethicist’s notion of covenant (brit) in light of theories found in the Jewish textual tradition. Clarifying an ethicist’s notion of covenant uncovers that person’s assumptions about the scope and binding nature of elements in the Judaic tradition, and that person’s conception of an audience’s responsibilities to the normative argument s/he articulates. Certain themes come to the fore for each ethicist that, when mapped, reveal striking relationships between an ethicist’s notion of covenant and anticipated ethical rhetoric. These maps begin to show why certain ethicists argue as they do. Discourse analysis then identifies the interrelationships between the speaker, the spoken and the audience – as they are actually articulated in Jewish ethicists’ practical arguments. These relationships form the how of Jewish ethical arguments insofar as they reflect an author’s rhetorical choices. My project applies discourse analysis to the rhetoric of a sample of living Jewish ethicists (J. David Bleich, Elliot Dorff, Eugene Borowitz) who speak out on issues of social concern and justice. As will be seen, a rich and complex relationship exists between an ethicist’s theory of covenant and his subsequent moral rhetoric. This twofold methodology enables the student of Jewish ethics to understand how and why seemingly disparate styles of normative speech are nonetheless participating in a common endeavor and discourse. And it supports the theologically-based rhetoric of religious ethical discourse in shaping justice in multi-cultural societies.
Sulphur Amino Acid Requirement and Metabolism in the Total Parenteral Nutrition (TPN) Fed Human Neonate
Keywords: sulphur amino acids
methionine
cysteine
glutathione
neonate
methionine requirement
parenteral nutrition
antioxidant
amino acid requirement
methionine requirement
parenteral nutrition associated cholestasis
cysteine metabolism
methionine metabolism
cystathionine
homocysteine
urinary sulphate
breakpoint analysis

Except for tyrosine, the amino acid requirement of parenterally fed (PN) human neonates has not been derived. Methionine and cysteine are indispensable and dispensable sulphur amino acids respectively. Cysteine is synthesized from methionine. Cysteine is unstable in solution, and is left out or added in very small amounts to amino acid solutions. Methionine is added to compensate for the lack of cysteine, assuming that the neonate will convert methionine to cysteine to meet the body’s metabolic demand. Methionine is hepatotoxic and there is evidence that the neonate has limited ability for its conversion to cysteine. To determine the requirement of the neonate for methionine, PN-fed, stable, post-surgical neonates received graded intakes of methionine. The mean methionine requirement was estimated to be 49 mg.kg-1.day-1, which is 48 to 90% of the methionine content of current commercial amino acid solutions. Because cysteine is the rate limiting substrate for glutathione (GSH) synthesis and current methods of determining amino acid requirement measure requirement for protein synthesis, SAA requirements for maintenance of GSH status was deleniated in healthy adult males and in PN-fed human neonates. GSH kinetics was measured in healthy men receiving the mean methionine requirement and graded intakes of cysteine. GSH synthesis did not change with the addition of cysteine. Additionally, PN-fed post-surgical neonates recieved a methionine-adequate cysteine-free PN followed by cysteine supplemented PN for two 3-day periods and GSH kinetics measured on days 3 and 6. There was no change in GSH synthesis in response to cysteine supplementation. It is concluded that the PN-fed human neonate is capable of synthesizing enough cysteine from methionine not only for protein synthesis but for GSH synthesis. For both healthy men and stable post-surgical neonates, the requirement for GSH synthesis is met at the sulphur amino acid requirement derived using the indicator amino acid technique
Targeted Auger Electron Radiotherapy of HER2-amplified Breast Cancer
Keywords: Breast Cancer
Radioimmunotherapy
Auger electron
Indium-111
HER2
Trastuzumab

Monoclonal antibodies (mAbs) conjugated to nuclear localization sequences (NLS) and labeled with Auger electron-emitters have great potential for targeted radiotherapy of cancer. This approach may be especially appropriate for the 25-30% of patients with breast cancer whose tumors display overexpression of HER2. Trastuzumab (Herceptin) is a humanized anti-HER2 mAb approved for immunotherapy of HER2-amplified breast cancer. The goal of this research was to radiolabel trastuzumab with [111]In, and to modify it with peptides harboring the NLS (CGYGPKKKRKVGG) of the simian virus 40 large-T antigen for targeted radiotherapy of breast cancer. It was hypothesized that the NLS-peptides would mediate the translocation of covalently linked [111]In-trastuzumab molecules into the nuclei of HER2-overexpressing breast cancer cells where subcellular-range Auger electrons are most damaging to DNA and lethal to cells. Trastuzumab was derivatized with sulfosuccinimidyl-4-(N-maleimidomethyl)-cyclohexane-1-carboxylate for reaction with NLS-peptides and labeled with [111]In using diethylenetriaminepentaacetic acid. The dissociation constant for binding of [111]In-NLS-trastuzumab to HER2-overexpressing SK-BR-3 human breast cancer cells was reduced < 3-fold compared to [111]In-trastuzumab, demonstrating relatively preserved receptor-binding affinity. The NLS-peptides did not affect the biodistribution of [111]In-trastuzumab, but promoted its nuclear uptake in HER2-overexpressing MDA-MB-361 xenografts. The cytotoxicity of [111]In-NLS-trastuzumab on breast cancer cells correlated with their HER2 expression. Moreover, [111]In-NLS-trastuzumab was 2-fold and 5-fold more potent at killing MDA-MB-361 and SK-BR-3 cells compared to [111]In-trastuzumab, and nearly 3-fold and 6-fold more effective than unlabeled trastuzumab, respectively. Methotrexate is a known radiosensitizer that can amplify the lethal effects of ionizing radiation on tumor cells. Non-cytotoxic, but radiosensitizing doses of methotrexate were therefore combined with [111]In-NLS-trastuzumab; this enhanced the sensitivity of HER2-overexpressing breast cancer cells to [111]In-NLS-trastuzumab. The blood t1/2 of [111]In-NLS-trastuzumab in non-tumor bearing BALB/c mice was 23-34 h when administered intravenously or intraperitoneally. The maximum tolerated dose was 9.2-18.5 MBq; doses >18.5 MBq caused decreased leukocyte and platelet counts. [111]In-NLS-trastuzumab exhibited strong anti-tumor effects against HER2-overexpressing MDA-MB-361 xenografts, reducing their growth rate 2-fold and 3-fold compared to mice administered [111]In-trastuzumab or unlabeled trastuzumab, respectively. These promising results suggest that [111]In-NLS-trastuzumab may be a useful Auger electron radioimmunotherapeutic agent for HER2-positive breast cancer in humans.
Episodes of Relationship Completion Through Song in Palliative Care
Keywords: Music therapy
palliative care
relationships
narrative
relationship completion

This study utilized a combination of intrinsic and instrumental case studies to describe the experience of four dying persons and their significant relations, as they engaged in music therapy sessions designed with the goal of facilitating relationship completion. The four primary participants were inpatients of the Baycrest palliative care program who were diagnosed with a terminal illness and a life expectancy of less than six months. Two spouses who were involved in music therapy sessions were co-participants. I developed four case studies to represent each of the rich and detailed stories. Through the use of narrative research methods I was able to describe, interpret, and understand the complexity held within the multiple data sources that informed each case study. Data sources included: music created, utilized, recorded, and/or discussed in music therapy sessions; discussions during music therapy sessions; the researcher’s field notes; formal notes placed in the participant’s medical charts; the formal written assessment; transcriptions of audio-taped music therapy sessions; interviews; interview transcriptions; artistic pieces crafted by myself that emerged from the experiences of the participants as reflected in their interviews, and weekly participation in sessions which were verified by the participants; and other artistic material. The rich knowledge that emerged from the individual case studies informed a cross-case analysis where global themes were identified from a thematic analysis of participants’ experiences; and process motifs arising from the progression of participant engagement in music therapy are described. Global themes included: love; loss; gratitude; growth/transformation; courage/strength; and goodbye. The five process motifs that emerged were: (1) music therapy helps and was valued as a means of sharing the participants’ perceptions of their situation. (2) music therapy provides a safe place to become aware of, explore, and express feelings. (3) music enhances communication. (4) music therapy techniques provide creative avenues for self-expression. (5) music therapy provided a vehicle for revisiting and reminiscing. The thesis concludes with a summary of the knowledge revealed and a discussion of implications for music therapists and health care professionals, as well as a presentation of final thoughts and reflections on my role as researcher in this study.
Self-assembly and Fibre Formation of Elastin-llke Polypeptides
Keywords: elastin
self-assembly
coacervation

Elastin is a polymeric protein of the extracellular matrix that imparts the characteristics of extensibility and elastic recoil to tissues. Recombinant polypeptides based on the domain structures and sequences of human elastin self-assemble into organized fibrous structures, with physical properties similar to those of native polymeric elastin. Elastin self-assembly is initiated by a temperature-induced phase separation, called coacervation. Previous to this work, coacervation temperature had been the only parameter available to measure propensity for self-assembly. A variety of techniques were developed using spectrophotometry, microscopy, and rheometry to differentiate the stages of self-assembly, thereby enabling independent observation and quantitation of each stage, and allowing investigations into properties of polypeptides and solution conditions affecting these stages. Kinetic analysis of self-assembly yielded two additional parameters: coacervation velocity and maturation velocity. Examining the effects of agitation, salt concentration, temperature, polypeptide concentration, size of a polypeptide, hydrophobic domain sequence, and cross-linking domain structure on the kinetics demonstrated that coacervation and maturation are independent stages of self-assembly involving distinct mechanisms. Microscopic observations showed that protein-rich droplets of coacervate grew by coalescence to a stable droplet size, which correlated to differences in maturation velocities between polypeptides. Coacervate droplet growth appeared limited by the formation of organized polypeptide at the surface of the droplets, decreasing surface fluidity. Many of the general principles of the physical chemistry of colloids and emulsions appeared to apply to the formation, growth and stabilization of coacervates of the elastin-like polypeptides. Self-assembly in the presence of non-elastin, matrix-associated proteins showed that these proteins maintained the coacervate as small droplets, which sometimes flocculated into fibre-like structures. Rheometry demonstrated a second temperature-induced transition above the coacervation temperature, which resulted in gelation and viscoelastic characteristics similar to microgels. Together, these observations have resulted in a greater level of understanding of the entire self-assembly process, and provided a comprehensive model of elastin-like polypeptide self-assembly that relates to in vivo assembly of elastic fibres.