VictorJuiz/thesis huggingface dataset:
The Value of Branding in Two-sided Platforms
Keywords: brand
two-sided platform
mcmc
laplace
demand estimation
slope endogeneity
random coefficient
dynamic

This thesis studies the value of branding in the smartphone market. Measuring brand value with data available at product level potentially entails computational and econometric challenges due to data constraints. These issues motivate the three studies of the thesis. Chapter 2 studies the smartphone market to understand how operating system platform providers can grow one of the most important intangible assets, i.e., brand value, by leveraging the indirect network between two user groups in a two-sided platform. The main finding is that iPhone achieved the greatest brand value growth by opening its platform to the participation of third-party developers, thereby indirectly connecting the consumers and the developers via its app store effectively. Without the open app store, I find that iPhone would have lost its brand value by becoming a two-sided platform. Hence these findings provide an important lesson that open platform strategy is vital to the success of building platform brands. Chapter 3 solves a computational challenge in structural estimation of aggregate demand. I develop a computationally efficient MCMC algorithm for the GMM estimation framework developed by Berry, Levinsohn and Pakes (1995) and Gowrisankaran and Rysman (forthcoming). I combine the MCMC method with the classical approach by transforming the GMM into a Laplace type estimation framework, therefore avoiding the need to formulate a likelihood model. The proposed algorithm solves the two fixed point problems, i.e., the market share inversion and the dynamic programming, incrementally with MCMC iteration. Hence the proposed approach achieves computational efficiency without compromising the advantages of the conventional GMM approach. Chapter 4 reviews recently developed econometric methods to control for endogeneity bias when the random slope coefficient is correlated with treatment variables. I examine how standard instrumental variables and control function approaches can solve the slope endogeneity problem under two general frameworks commonly used in the literature.
Essays on Money, Business Cycles and Household Formation
Keywords: Illiquid Bonds
Societal Welfare
Search Model
Money
Delayed Output Response
Productivity Shocks
Marriage
Money
Markets
Households
Business Cycles

This dissertation consists of three independent essays in Macroeconomics. The ﬁrst essay studies whether efficiency can be improved by introducing government-issued illiquid bonds to an economy where money is the only asset and essential. In contrast with perfectly liquid bonds, illiquid bonds can increase societal welfare in two ways: First, allocating consumption goods among heterogeneous agents more efficiently; second, stimulating consumption and output level by loosening the liquidity constraints of households. More importantly, since societal welfare is elevated persistently when the inﬂation rates range from a level slightly above Friedman Rule to an upper bound, this essay provides an insight into the essentiality of illiquid bonds. The second essay provides a novel propagation mechanism of productivity shocks to explain an empirical fact: The response curve of output to a positive productivity shock reaches its peak up to eight quarters after the shock. Using a micro-founded monetary search model and focusing on agents’ decisions on establishing long-term trading relationships in the goods market, I show that when a positive shock takes place in the economy, marginal agents break down previous trading relationships and explore better matching opportunities. As a result, shortly after the shock, the average productivity level of transactions increases, but the total number of transactions decreases. The calibrated model shows that the latter effect dominates, resulting a slightly decrease of aggregate output after a positive productivity shock. The search friction, together with the monetary channel, gives rise to a delayed output response at the aggregate level. The third essay develops a general equilibrium theory of household formation – i.e., marriage – following Coase’s theory of ﬁrm formation. Individuals in the model consume both market-and home-produced commodities, and home production is facilitated through marriage. Market frictions, including taxation, search and bargaining problems, increase marriage rates when home and market goods are substitutes. In particular, inﬂation, as a tax on market activity, makes household production and hence marriage more attractive, as long as singles use cash more than married individuals, which is supported by data. The prediction that inﬂation and other taxes affect household formation is also supported by evidence.
Atomic Force Microscopic, Electron Spectroscopic Imaging and Molecular Simulation Investigations of the Assembly and Structures of Collagen Constructs
Keywords: collagen
Atomic Force Microscopy
Molecular Simulation
Electron Spectroscopic Imaging
segmental long spacing collagen
native collagen

Collagen is one of the major protein constituents in mammals and is present in all tissues and organs with the exceptions of keratin tissues such as hair and nails. Collagen monomers self-aggregate into a number of structures. In order to understand the physical bases for the structural polymorphism observed in collagen, a good starting point is one of the simplest collagen aggregates, segmental long spacing (SLS) collagen. Although SLS collagen formation induced by the presence of adenosine 5’-triphosphate is widely known, effects of other triphosphates, on the other hand, are much less studied. By varying the pH, it is discovered that all the nucleoside 5’-triphophsates, as well as inorganic triphosphate, are able to induce SLS formation over certain pH ranges. Adenosine 5’-diphosphate and para-nitrophenylphosphate cannot induce SLS formation at any pH. Based on the pH ranges at which SLS collagen can be formed, it is concluded the triphosphate functionality, with one negative charge per phosphate group, is primarily responsible for the formation of SLS collagen. Since inorganic triphosphate is able to induce SLS collagen formation, the presence of the nucleoside is optional for the assembly process; however if present, the assembly process prefers the nucleosides carrying acidic protons. Using electron spectroscopic imaging (ESI) technique, it is found phosphorus, present only in nucleotides but not in polypeptides, is localized in certain regions of SLS collagen, forming a unique banding pattern transverse the long axis of the SLS collagen. Nitrogen mapping indicates the localization of phosphorus is not due to accumulation of materials. The phosphorus banding pattern demonstrates an excellent consistency across SLS collagen assembled from both bovine and recombinant human collagen monomers. Results from molecular simulation are consistent with the experimental results. All threephosphate groups seem to be involved in the assembly process to some degree. In the last chapter of the thesis, a reliable protocol to synthesis native type collagen fibers is introduced.
Organizing Cellular Heterogeneity in High-grade Serous Cancer
Keywords: Ovarian Cancer
Cancer Stem Cell
CyTOF
CD133

High-grade serous ovarian cancer (HG-SOC) is the most lethal gynecologic malignancy. Although most respond to initial therapy, the vast majority of patients eventually recur and die of their disease. Understanding intra-tumor cellular heterogeneity and inter-patient variability is necessary to effectively cure HG-SOC. The work described in this thesis should help to speed the progress of ovarian cancer research in several ways. First, I generated a robust xenograft model that recapitulates the cellular heterogeneity of HG-SOC. In addition, I performed gene expression profiling on a subset of xenografts and showed that they recapitulate the inter-patient diversity of this disease. Second, I applied this model to pre-clinical testing of a folate-targeted imaging agent and showed that it can identify metastatic studding by PET/CT and fluorescence imaging. Using my xenograft model, I investigated the properties of tumor-initiating cells (TIC) and demonstrated that TIC in HG-SOC are rare. Furthermore, although CD133 marks most TIC, heterogeneity in the phenotype is observed within individual tumors and between different patients. Finally, I used a transformative technology, CyTOF, to develop a novel pipeline for prioritization of candidate TIC markers, as well as for characterization of cellular heterogeneity in primary HG-SOC samples.
Path/Action Planning for a Mobile Robot
Keywords: mobile robot
autonomy
field robotics
path planning

This thesis consists of two parts united by the theme of path/action planning for a mobile robot. Part I presents the Second Opinion Planner (SOP), and Part II presents a new paradigm for navigating, growing, and planning on a Network of Reusable Paths (NRP). Path/action planning is common to both parts in that the planning algorithm must choose the terrain assessment or localization technique at the path-planning stage. Terrain-assessment algorithms follow the trend of low-fidelity at low-cost and high-fidelity at high-cost. Using a high-fidelity method on all the raw terrain data can drastically increase a robot's total path cost (cost of driving, planning, and doing the terrain assessment). SOP is a path-planning algorithm that uses a hierarchy of terrain-assessment methods, from low-fidelity to high-fidelity, and seeks to limit high-cost assessment to areas where it is beneficial. The decision to assess some terrain with a higher-fidelity method is made considering potential path benefits and the cost of assessment. SOP provides a means to triage large amounts of terrain data. The system is demonstrated on simulated problems and in real terrain from an experimental field test carried out on Devon Island, Canada. The SOP plans are quite close to the minimum possible cost. Growing a NRP is an approach to navigation that allows a mobile robot to autonomously explore unmapped, GPS-denied environments. This new paradigm results in closer goal acquisition and a more robust approach to exploration with a mobile robot, when compared to a classic approach to guidance, navigation, and control. A NRP is a simple Simultaneous Localization And Mapping system that can be shown to be a physical embodiment of a Rapidly-exploring Random Tree planner. Simulation results are presented, as well as the results from two different robotic test systems that were tested in planetary analogue environments. NRP offers benefits to planetary exploration by allowing a rover to be used for the parallel scientific investigations. This increases the number of sites that can be investigated in a short time, as compared to a serial approach to exploration. Two mock missions were carried out at planetary analogue sites.
Prophetic Scribalism: A Semantic, Textual and Hypertextual Study of the Serek Texts
Keywords: Dead Sea Scrolls
Serek Texts
Isaiah
Second Temple Judaism
Prophecy
Legal Texts
War Scroll
Community Rule
Damascus Document
Allusion

This thesis challenges the position that the serek texts are primarily prescriptive and legal, as they have been customarily defined. It argues that the term serek should be reconceptualized according to descriptive analysis, with the purpose of creating what C. Newsom terms a ‘Gestalt structure.’ In order to achieve this, four serek texts (M, S, Sa, and D) will be analyzed at three literary levels—semantic, textual and hypertextual—explaining how the elements at these levels interact as cohesive wholes, thus serving to create a more complete picture of this group of texts as a literary unity. Thus, while the separate, constituent semantic, textual and hypertextual parts must be analysed as separate elements, the fundamental questions posed regarding these elements will be different in a Gestalt paradigm as compared to a traditional, definitional analysis. Going from the micro to the macro, the first chapter will look at the serek texts through the ‘microscope’ of close philological analysis, examining how the term serek functions atomistically within the Dead Sea Scrolls. Building upon these results, the second chapter will more broadly analyse the structure, themes and narrative apparent in the serek texts, thus creating a fuller understanding of how the serek texts relate to one another and respond to circumstances in community life. Finally, the last chapter seeks yet more broadly to understand the serek texts in the wider literary milieu of the Second Temple Period. Here, a scribal technique present in the serek texts will be compared to a similar technique used in the Book of Isaiah—arguably the most important prophetic work for the Qumran sectarians.
Physical and Functional Characterization of the SUMO System and SUMO Chains in S. cerevisiae
Keywords: yeast
SUMO
Proteomics
AP-MS

The ubiquitin-like proteins (Ubls) are small polypeptides that function as post-translational modifiers. Like ubiquitin, most Ubls are covalently attached to a lysine residue on target proteins. The small ubiquitin-related modifiers (SUMO) play important roles in a number of critical biological processes, such as proliferation and regulation of the cell cycle, yet their specific cellular functions have remained poorly understood. Like ubiquitin, SUMO proteins can also form oligomeric “chains”, but the functions of these structures were even less well understood. To this end, I created the first spectral library for the identification of Ub/Ubl proteins and Ub/Ubl chain linkages in mass spectrometry experiments. This tool has dramatically improved our ability to use MS to analyze the contents of biological samples for Ub and Ubls, and to identify specific types of Ub and Ubl chains in model organisms. I also used MS to conduct the first comprehensive SUMO system protein-protein interactome in any organism. In total, 452 high confidence protein-protein interactions were detected for S. cerevisiae SUMO system proteins, encompassing a total of 321 interacting partners. Yeast SUMO system components were found to interact with proteins involved in a number of different biological processes, and my mapping effort increased the number of known SUMO system interacting partners >50-fold. This study revealed that a number of transcriptional co-repressors and chromatin remodelling proteins interact physically with specific SUMO system components, with a clear division of labour between SUMO system enzymes. Finally, I conducted the first global analysis of SUMO chain function, using a combination of genetic, high-content microscopy, and high-density transcriptomics screens. Consistent with my interactomics work, this study demonstrated that inhibition of SUMO chain synthesis leads to severe chromatin condensation defects, which in-turn leads to chromosome missegregation, unscheduled transcription of stress-and nutrient-regulated genes, and aberrant intragenic transcription. Together, my work thus revealed a major role for the SUMO system in the maintenance of higher order chromatin structure and transcriptional repression.
Settling for Less out of Fear of Being Single
Keywords: Social Psychology
Romantic Relationships

The present research explores a novel construct of fear of being single, without a romantic partner. This research demonstrates that those who fear being single may lower their relationship standards without realizing it, even accounting for constructs typically examined in relationship research such as anxious attachment and neuroticism. Study 1 explored the content of people’s thoughts about being single. Studies 2A and 2B involved the development and validation of the Fear of Being Single scale. Study 2C provided preliminary support for the hypothesis that fear of being single predicts settling for less in ongoing relationships, showing that fear of being single predicted greater dependence on unsatisfying relationships. Studies 3A and 3B explored the predictive ability of fear of being single for self-reported dating standards. Across both samples, fear of being single was unrelated to self-reported standards for a mate, with the exception of consistently higher standards for parenting. However, Studies 4 and 5 explored romantic interest in targets that were manipulated to vary in responsiveness (both Studies 4 and 5) and physical attractiveness (Study 5 only). These studies found that fear of being single consistently predicted higher levels of romantic interest in less responsive and less attractive dating targets. Taken together, the present research suggests that fear of being single is a meaningful predictor of settling for less in relationships.
The Effectiveness of an Alternative Alcohol Taxation Method in a Middle-income County: A Case Study of Thailand
Keywords: alcohol
taxation
consumption
harm
drinking initiation
middle-income country
Thailand
policy

Background: While specific taxation has been found to be effective in reducing alcohol consumption and its related harms in High-Income Countries, it theoretically encourages drinking initiation in Low- and Middle-Income Countries (LMIC) with a high prevalence of lifetime abstainers. This dissertation aims to systematically review the existing evidence of the effects of taxation in LMIC on alcohol consumption, alcohol-related harms, and the rate of drinker initiation, and to examine how changes in Thailand’s Two Chosen One (2C1) taxation rates affect alcohol consumption, related harms and drinking initiation. Method: (1) A systematic review and meta-analysis that examines the effects of taxation policy on alcohol consumption, alcohol-related harms and the rate of drinker initiation in LMIC. (2) A quasi-experimental study using interrupted time-series analysis that examines the effects of alcohol taxation increases in Thailand on alcohol consumption and traffic fatalities. (3) An analysis of four consecutive national surveys on alcohol consumption behaviours to examine the effect of alcohol tax increases on drinking initiation prevalence in Thailand. Result: There were only 10 published studies that quantitatively examined the effect of alcohol taxation policy on consumption in LMIC. In LMIC the price elasticity of demand was -0.64 for all alcohol consumption, -0.50 for beer consumption, and -0.79 for consumption of other alcohol. No studies were found that examined the effects of taxation policy on alcohol-related harms and drinking initiation in LMIC. Thailand’s alcohol taxation increase in 2009 was associated with a reduction in alcohol consumption (tax elasticity of -1.95) and in traffic fatalities (tax elasticity of -1.90). Increased taxation prevented drinking initiation among young people 15 – 24 years of age during 2001-2011 in Thailand (tax elasticity of -0.40). Conclusion: Increases in taxation under the 2C1 taxation method were associated with decreases in alcohol consumption, alcohol-related harms and drinking initiation.
A Generic Simulation-based Perioperative Decision Support Tool for Tactical Decision
Keywords: simulation
healthcare
surgery
perioperative
generic modelling
decision support

In Canada and around the world, there has been an increased focus on the efficiency, cost and access to health care services. One area of particular focus is surgical procedures, often with government funding and policies focused on reducing wait times through pay for performance and volume target initiatives. In Ontario, an expert panel was assembled to evaluate the current state of surgical processes and provide recommendations to improve access, efficiency and quality. This thesis addresses the panel's recommendation for a simulation-based decision tool to help hospitals inform decisions that can lead to improved access and efficiency. A generalised, simulation based perioperative decision tool is presented that can be used to test a variety of tactical decisions. The generic model has been applied to six hospitals of varying sizes, ranging from large academic centres to small rural community hospitals. The model remains in use at some of the hospitals to regularly inform decisions. The model is also being applied to additional hospital sites. During application of the generic model, challenges in design decisions and validation were encountered. As a result, a series of principles are proposed to guide future generic modelling design and achieving user acceptance. These principles add to the generic simulation modelling and healthcare modelling research fields by laying some groundwork for a formalised approach to designing effective generic simulation models and achieving confidence in results. Finally, the research demonstrates two uses of the generic model: as decision tool and as a demonstrative tool. As a decision tool the model is used to compare numerous potential tactical decision options under consideration. As a demonstrative tool, the model is used to quantify the effect of poor practices on hospital performance. The design of the generic model only considers efficient processes and best practices. When model results are compared to historical performance, decision makers are able to quantify the effect of existing poor practices on their performance and decision making. The tool enables users to base their tactical level decisions on the assumption that good practices and procedures are followed.
Performance Excellence: Toward a Model of Factors Sustaining Professional Voice Performance in Opera
Keywords: Performance excellence
Opera
Deliberate practice
Self-efficacy

While considerable research has explored the skills elite professionals use to sustain performance excellence in a multitude of disciplines, much less research has focused on professional musicians. Multi-faceted skills are needed to maintain performance excellence. This research investigates the deliberate skills and processes professional opera singers employ to preserve elite performance. Data drawn from individual semi-structured interviews with ten professional opera singers, with a minimum career length of ten to twenty years, were analyzed within the methodology of grounded theory. Results revealed a strong role for creation of a music "road-map" in the context of deliberate preparedness in both physical and mental skills, which contributed to high levels of learning self-efficacy. High-level skills cultivated in the preparation phase were applied directly within the context of live performance, facilitated "flow" experiences, involved energy exchanges with other performers and audiences, and resulted in higher levels of performing self-efficacy.