VictorJuiz/thesis huggingface dataset:
Effect of the Mahatma Gandhi National Rural Guarantee Act on infant malnutrition: a mixed methods study in Rajasthan, India
Keywords: infant nutrition
malnutrition
employment
policy
social determinants

Background
Malnutrition is a major risk factor of infant mortality in India. Policies targeting poverty and food insecurity may reduce infant malnutrition. The Mahatma Gandhi National Rural Employment Guarantee Act (MGNREGA), a wage-for employment policy of the Indian Government, targets deprivation and food insecurity in rural households. MGNREGA could prevent infant malnutrition by improving household food security or increase the risk of malnutrition by reducing the time devoted to infant care if mothers are employed. This study analyzed the effect and the pathways of effect of households’ and mothers’ participation in MGNREGA on infant malnutrition.
Methods
A community based mixed methods study using cross-sectional survey and focus group discussions (FGDs) was conducted in Dungarpur district of Rajasthan, India. Cross-sectional study included 528 households with 1,056 participants who were infants 1 to <12 months and their mothers/caregivers. Selected households were divided into MGNREGA-households and non-MGNREGA-households based on participation in MGNREGA between August-2010 and September-2011. Anthropometri indicators of infant malnutrition–underweight, stunting, and wasting (WHO criteria) were the outcomes. Eleven FGDs with 62 mothers were conducted.
Results
Of 528 households, 281 participated in MGNREGA (53%). Mothers were employed in 51 (18%) households. Prevalence of wasting was 39%, stunting 24%, and underweight 50%. Households participating in MGNREGA were less likely to have wasted infants (OR 0•57, 95% CI 0•37–0•89; p=0•014) and underweight infants (OR 0•48, 95% CI 0•30–0•76; p=0•002) than non-participating households. Stunting did not differ significantly between groups. Although MGNREGA reduced starvation, it did not confer food security to the participating households because of lower than standard wages and delayed payments. Results from path analysis did not support an effect through household food security and infant feeding, but suggested a pathway of effect through birth-weight. Mothers’ employment had no significant effect on the outcomes in the cross-sectional study, but the qualitative study indicated that it could compromise infant feeding and care.
Conclusion
Participation in MGNREGA was associated with reduced infant malnutrition possibly mediated indirectly via improved birth-weight rather than improved infant feeding. Providing child care facilities at worksites could mitigate the negative effects of mother’s participation in MGNREGA. Further, improving mothers’ knowledge of appropriate feeding practices in conjunction with providing employment (to address deprivation and food insecurity) is key in the efforts to reduce infant malnutrition.
Genes in space: selection, association and variation in spatially structured populations
Keywords: Popultaion genetics
Statistical genetics

Spatial structure in a population creates distinctive patterns in genetic data. There are two reasons to model this process. First, since the genetic structure of a population is induced by its historical spatial structure, it can be used to make inference about history and demography. Second, these models provide corrections to other analyses that are confounded by spatial structure. Since is it is now common to collect genome-wide data on many thousands of samples, a major challenge is to develop fast, scalable, approximate algorithms that can analyse these datasets. A practical approach is to focus on subsets of the data that are most informative, for example rare variants.
First we look at the problem of estimating selection coefficients in spatially structured populations. We demonstrate this approach using classical datasets of moth colour morph frequencies, and then use it in a model incorporating both ancient and modern DNA to estimate the selective advantage of one of the best known examples of local adaptation in humans, lactase persistence in Europeans.
Next, we turn to the problem of association studies in spatially structured populations. We demonstrate that rare variants are more confounded by non-genetic risk than common variants. Excess confounding is a consequence of the fact that rare variants are highly in- formative about recent ancestry and therefore, in a spatially explicit model, about location.
Finally, we use this insight into rare variants to develop methods for inference about population history using rare variant and haplotype sharing as simple summary statistics. These approaches are extremely fast and can be applied to genome-wide data on thousands of samples, yet they provide an accurate description of the history of a population, both identifying recent ancestry and estimating migration rates between subpopulations.
The landscape of recombination in African Americans: leveraging human population variation to investigate homologous recombination
Keywords: recombination

Homologous recombination is a highly regulated and complex biological process required for sexual reproduction in humans and many other species. The mechanisms of initiation and control of this process, however, are only partially understood. The aim of this work is to tease apart and utilize the differences in recombination localization between human populations to understand the underlying biological processes.
Privacy-preserving targeted advertising for mobile devices
Keywords: Mobile Devices
Advertising
Pirvacy

With the continued proliferation of mobile devices, the collection of information associated with such devices and their users --- such as location, installed applications and cookies associated with built-in browsers --- has become increasingly straightforward. By analysing such information, organisations are often able to deliver more relevant and better focused advertisements. Although such Targeted Mobile Advertising (TMA) offers great benefits to advertisers, it gives rise to a number of concerns, with privacy-related concerns being prominent amongst them. It follows that there is a need for an advertisement-selection mechanism that can support the existing TMA business model in a manner that takes into account consumers' privacy concerns.
The research described in this dissertation explores the delicate balance between the goals of the advertisers and the consumers: advertisers pursue profits by applying TMA, which violates consumers' privacy; consumers hope to benefit from useful mobile advertisements without compromising their personal information. The conflicts of interests between consumers and advertisers in the context of targeted mobile advertising brings us to our research question: Is it possible to develop a privacy-preserving TMA framework that enables mobile users to take advantage of useful advertising services without their privacy being compromised, and without impacting significantly advertising effectiveness?
In order to answer this question, this dissertation presents four main contributions. First, we report upon the result of a qualitative study to discuss the balance that needs to be struck between privacy and utility in this emerging area. Second, a number of formal models are developed to reason about privacy, as well as to reason about the relationship between privacy and utility in the context of TMA. Third, a novel ad-selection architecture, PPTMA (Privacy-Preserving Targeted Mobile Advertising), is presented and evaluated. Finally, a privacy-preserving advertisement-selection mechanism, AdSelector, is introduced. The mechanism is novel in its combination of a user subscription mechanism, a two-stage ad-selection process, and the application of a trustworthy billing system.
Synthesis and development of light-activated molecular probes
Keywords: caging
photolabile
amino acid
caged
photolysis
peptide

Judicious addition of photolabile caging groups (PCGs) to protect biologically im- portant molecules, has enabled the development of many powerful chemical tools for the study of biological processes. These tools have the potential to be activated in a cellular setting by irradiation with light of appropriate wavelengths, restoring functionality, with excellent spatial and temporal control.
This D. Phil. dissertation highlights two biologically relevant examples where PCGs can be applied: (i) 4,5-dimethoxynitrobenzyl (DMNB) caged derivatives of GSH and ESG, were synthesised and uncaging of the DMNB group at 350 nm to reveal the free α-carboxylic acid of the glycine residue was demonstrated. These molecules have the potential to probe the binding mode within the KefC KTN binding domain, a ligand-gated K+ efflux system, critical for bacterial response to electrophilic assault. The molecules are currently with collaborators awaiting further evaluation.
(ii) The wavelength-dependent application of PCGs toward the study of protein post- translational modifications (PTMs) was developed. PTMs modulate protein function and have a ubiquitous role in a diverse range of cellular functions.
A wavelength selective sequential pair of PCGs was developed and demonstrated in a tripeptide, using the diethylamino coumarin (DEACM), which was cleaved at 420 nm, and the DMNB caging group, which was subsequently cleaved at 350 nm.
A chromatically orthogonal pair of PCGs, with possible applications in both organic synthesis and biological systems, incorporating the BODIPY-based and DEACM caging groups, which could be cleaved at 530 nm and 420 nm, respectively, was also developed.
Photolysis was conducted on a tripeptide and hexapeptide and an in vitro application was demonstrated where when caged, the peptide was not susceptible to peptidolysis when incubated with enzymes. Following irradiation at 420 nm, the DEACM group was uncaged and the peptide underwent peptidolysis in the presence of Endoproteinase AspN, whereas following irradiation at 530 nm to uncage the BODIPY group, the peptide underwent peptidolysis in the presence of Endoproteinase LysC. These results not only provide conclusive evidence of the ability of this pair of caging groups to act in a wavelength orthogonal sense but also demonstrates the potential applicability of the pair to biochemical studies.
This pair of PCGs represents the first example of an orthogonal pair of caging groups where both PCGs could be cleaved, at wavelengths longer than 400 nm, in a sequence independent manner.
Exploring the causes and consequences of phenological change in a wild bird population
Keywords: Great tit
Population dynamics
Climate change
Phenology

Changes in climate shape biological populations. They can alter spatial distributions, the timing of life history events, and even the species themselves. We are now experiencing a period of rapid directional climate change, alongside seasonal fluctuations. This thesis investigates temporal changes in life history events, phenology, as a climate response. I explore the causes and population level consequences of change in breeding phenology of two wild bird populations from Wytham Woods, UK.
I test how great tits (Parus major) and blue tits (Cyanistes caeruleus) achieve temporal synchrony between the peak demands of their breeding and the peak abundance of their prey species (winter moth caterpillars - Operophtera brumata) in an inter-annually variable environment. I demonstrate great tit (Parus major) incubation behaviour fine-tunes the timing of hatching in response to ambient temperatures right up until hatching (Chapter two). Temperatures within the nest box, however, appear to play little role in the breeding phenology of blue tits (Cyanistes caeruleus) (Chapter two). I discuss the merits and limitations of statistical approaches for cue identification (Chapter six), finding the method and time period of data used both affect the cue identified and predictive accuracy.
The second part of this thesis explores the influence of a directionally changing environment on great tit phenology. I use an integral projection model (IPM) to predict population dynamics over the 21st century, showing that if the cues used by both interacting species change sufficiently closely, temporal synchrony can be maintained through both phenotypic plasticity and micro-evolution (Chapter 5). However, if the cues diverge mismatch will arise (Chapter 5) causing population declines when certain thresholds are passed (Chapter 4).
This work contributes to understanding how phenological synchrony is achieved, how it might change in the future, and its population impacts. In Wytham Woods it appears that great tits have a great deal of flexibility in multiple components of their breeding cycle, allowing them to retain synchrony with their caterpillar prey in a fluctuating environment. These birds are relatively resilient to negative phenological impacts from climate change. Only if the cues used by the predator and prey completely diverge do we predict consistent declines in population size during this century.
Salience, authority, and resources: explaining victims' compensation in postwar Bosnia and Herzegovina
Keywords: Sarajevo
Transitional justice
Srebrenica
Veterans
War
Bosnia and Herzegovina
Victims
Prijedor

The aim of this thesis is to probe subnational varieties in compensation enacted for war victims in post-war Bosnia and Herzegovina. The current literature in transitional justice posits that mainly the nature of previous conflicts, democratic and economic development, international normative pressures, and the regional clustering of justice explain why only some post-war countries award material assistance to victims (Olsen et al. 2010; Kim 2012; Risse and Sikkink 2013; Powers and Proctor 2015). While these explanations provide critical insights into the processes behind compensation adoption across states, they do not explain why only some victim categories within a state secure compensation. Drawing on a large database of qualitative data ranging from interviews to newspaper articles collected during fieldwork in Bosnia, this thesis explores compensation for military and civilian war victims, victims of torture and sexual violence, and families of missing people. By zooming in on these victim categories in the Bosnian context, this thesis advances a new understanding of compensation for victims as an outcome of complex political, external, and economic influences exerted on the main domestic policymakers. This thesis uses a new analytical framework about the inter-category varieties in compensation that draws upon arguments about bounded agency of war victims who are constrained by the parameters of post-war political structures that to a large degree shape their strategies. I show that the different compensation outcomes can primarily be explained by the varying effectiveness of victims in convincing domestic political authorities that compensation is in their political interest by using framing and advocacy strategies at the domestic and international level. While such strategies are limited by the political and socioeconomic characteristics of the state, victim categories that are able to strategically frame their demands and access resources to mobilize are more likely to secure compensation adoption. Therefore, this thesis introduces three tools that victims can leverage – international salience, moral authority, and mobilization resources – that are shaped by both structural conditions and the victims’ agency.
Organizational modes of non-state armed groups
Keywords: group property
Modes theory
cultural evolution
Galton's problem
resource extraction
armed group
ritual

To what extent can two 'Modes' be found amongst non-state armed groups (NSAGs)? The Modes theory hypotheses that NSAGs are organized into two distinct Modes, either the 'Imagistic' or the 'Doctrinal' Mode, with each Mode characterised by a particular organisational structure and type of resource extraction. Previous preliminary research on this had three limitations: 1) it used a sample of only five groups; 2) "Galton's problem", i.e. non-independence of groups was not taken into account, and 3) the theory of resource extraction was underdeveloped. The present research overcomes each of these limitations.
First, can the patterns found in the 5-group case study be replicated with a larger sample? A dataset with 50 NSAGs was constructed, with variables that were derived from the theory and resembling those used for the 5-group case study. Analysis results showed that a few 'Doctrinal' variables were significantly correlated and 'Doctrinal' rituals had a frequency distribution as predicted. Yet, most correlations between all Modes variables were not significant, and analyses did not convincingly show that there were two distinct Modes.
Second, to what extent does "Galton's problem" (autocorrelation) play a role amongst NSAGs regarding their Modes properties? Data on relations between armed groups and their geographical locations were added to the sample. Using Moran's I, it appeared that two to four Modes properties were significantly autocorrelated. With geographical region as covariate, analyses were redone. Results remained basically the same as without regional covariate.
Third, what is the relationship between Modes and the type of Resource extraction? Resource types were operationalized and Resource type data were added to the sample of NSAGs. A theory on Risk, and a ROI (Return on Investment) and Risk index were developed. Regressions showed no change in ROI or Risk over time. Low ROI did not typically predict Doctrinal-related Modes properties, and high-ROI did not typically predict Imagistic-related Modes properties. The significance of relations between Modes properties and Resource types strongly depended on whether the analysis was a correlation or a regression. Overall, only a few relationships were significant and no consistent pattern emerged.
Limitations of the present research, and suggestions for further research are discussed, as well as an overall assessment of the Modes theory.
Correlation of optical anisotropy with structural changes in Ge2Sb2Te5
Keywords: Circular dichroism spectroscopy
Reduced density function (RDF) analysis
Phase change material
Chalcogenide
Athermal amorphous-to-crystalline phase transition
Optically-induced chirality

Ge2Sb2Te5 (GST) is an established phase-change material that undergoes fast reversible transitions between amorphous and crystalline states with a high electro-optical contrast, enabling applications in non-volatile optical and electronic memories and optically-switchable structured metamaterials. This work demonstrates that optical anisotropy can be induced and recorded in pure and doped GST thin films using circularly polarised light (CPL), opening up the possibility of controlled induction of anisotropic phase transition in these and related materials for optoelectronic and photonic applications. While the amorphous-to-crystalline phase transition in GST has generally been understood to proceed via a thermal mechanism, significant optical anisotropy (measured by circular dichroism (CD) spectroscopy in this work) strongly suggests that there is an electronic athermal component of the phase change induced by the handedness of circularly polarised nanosecond laser pulses and implies the existence of chiral structures or motifs. Optically active and inactive regions in the films have also been studied using X-ray and electron diffraction and spectroscopic techniques in order to obtain a structural picture that can be correlated to the optical changes observed and the findings offer surprising evidence of the nature of the phase transition. Regions exhibiting higher CD signal intensities were found to be mostly amorphous with elemental phase separation observed within modified surface features. Several mechanisms are proposed for the observed phenomena, including the retention of chiral crystalline fragments in laser- irradiated and melt-quenched amorphous regions, which could explain the results of CD spectroscopy. This may be extended to other material systems and harnessed in potential metamaterials, plasmonics, photonics or chiroptical applications.
Raising European citizens? European narratives, European schools and students' identification with Europe
Keywords: education
Europe
process tracing
citizenship
European identity
nationalism
identity
teachers
European Union
schools
narratives

Fostering identification with Europe among citizens could legitimise European integration. Whether such an identity exists, however, remains an on-going debate among scholars. This research returns to the foundations of how a European identity is constructed, transmitted and transformed. It explores narratives of European identity in a carefully chosen context – European Schools for children of EU officials – where identification with Europe should mirror official EU visions. A qualitative content analysis explores narrations of 101 students collected during interviews and focus groups across three schools, and analyses documents and interviews with EU officials, school directors and teachers. This analysis reveals a descriptive puzzle: official EU and European School propositions of (multi-) national narratives differ markedly from teachers' and students' conceptions of cosmopolitan and transnational identities. The EU constructs an out-group of its own nationalist past and non-EU citizens. On the other hand, students construct an explicitly European in-group, but differentiate themselves from more national and less mobile lifestyles. This disparity, in turn, reveals a causal puzzle about how differences in narratives emerge. I use process tracing to elucidate the relationship between European schooling and students' identification with Europe. The results show a distorted transmission where broader EU goals are elaborated and transformed by teachers and further fuelled by interactions amongst students with similarly mobile and multilingual backgrounds. I develop a dual mechanism to understand how the varieties of identification with Europe develop: the concept of "doing Europe" explains how students nourish a transnational social network; "telling Europe", on the other hand, considers students' exposure to European symbols and stories in school and both national and anti-nationalist narratives provided by teachers and peers. Together, this leads to a transformed but ultimately European in-group understanding. Overall, this project underlines the complexity of identity construction, given that top-down transmission gets altered even in this favourable case. Specifically, it informs future research on European identity by detailing peculiar narratives and offering a causal approach to how these narratives emerge.