VictorJuiz/thesis huggingface dataset:
Causes and consequences of maternal sepsis in the UK
Keywords: sepsis
epidemiology
maternal health
severe sepsis

Background: The rate of maternal death from sepsis has increased in several European countries, most notably the UK, where sepsis is now the leading cause of direct maternal death. An increase in maternal mortality also implies an increase in the number of women with severe, life-threatening morbidity. Key information gaps in the understanding of severe maternal sepsis in the UK are: the incidence, main causative organisms, infection sources, and risk factors for severe maternal sepsis.
Methods: Four population-based observational studies were conducted to address these evidence gaps.
Results: The incidence of severe maternal morbidity from sepsis is increasing in the UK, a trend also evident in the USA. The most common sources are respiratory tract, genital tract and urinary tract infection. The predominant organisms causing infection are E. coli, group A streptococcus, and strong circumstantial evidence of Streptococcus pneumonia. Sepsis progresses very rapidly particularly with group A streptococcal infection. Approximately 20% of women with severe sepsis progress to septic shock and 2% of women die.
Risk factors for severe maternal sepsis in the UK with a large effect size are: febrile illness or antibiotics in the 2 weeks prior to onset of severe sepsis (aOR=12.1, 95% CI 8.1-18.0), caesarean section after the onset of labour (aOR= 8.1, 95% CI 4.7-14.0), multiple pregnancy (aOR= 5.8, 95% CI 1.5-21.5), infection with group A streptococcus (aOR=4.8 for progression to septic shock, 95% CI 2.2-10.8), pre-labour caesarean section (aOR= 3.8, 95% CI 2.2-6.6), low socioeconomic status (aOR=2.6, 95% CI 1.03-6.7), and operative vaginal delivery (aOR=2.5, 95% CI 1.3-4.7). Risk factors are significantly cumulative.
Conclusions: Infection prior to or after delivery, even if the woman appears to be well, should be a marker for close clinical monitoring. Suspicion of group A streptococcus should be regarded as an obstetric emergency and treated ahead of laboratory confirmation.
A measurement of the ratio of the W+1 jet and Z+1 jet cross sections using the ATLAS detector at the LHC.
Keywords: Standard Model
LHC
ATLAS

The first measurement of the ratio of the W and Z cross sections in association with a single jet, known as the R_{Jets} measurement, is presented. The measurement was performed using 33pb^-1 of integrated luminosity, recorded during the year 2010 by the ATLAS detector at the LHC. At this time the LHC was operating at a center-of-mass energy of 7 TeV. The measurement is made as a function of the threshold on the jet transverse momentum, from 30 GeV up to a value of 200 GeV. The motivation for this measurement is outlined in terms of providing a stringent test of the Standard Model of particle physics, as well as a model independent tool for searching for new physics. Data driven tools are developed to perform the measurement and their performance is discussed. The result of the measurement is compared with the predictions of Next-to-Leading order perturbative QCD and found to be in good agreement over the entire range of transverse momenta considered.
Moral emotions as antecedents of political attitudes
Keywords: conservative
moral emotions
political attitudes
liberal
disgust

The main objective of this thesis was to investigate the proposition that moral emotions act as antecedents of political attitudes. My approach (Chapter 1) stems from moral foundations theory, which proposes that liberals and conservatives have different moral values (Graham, Haidt, & Nosek, 2009). Chapter 2 presents Study 1, an experimental test of the hypothesis that induced disgust leads participants to adopt more left-wing economic attitudes in comparison to a control condition (sadness). Results supported this hypothesis. Chapter 3 reviews emotion-regulation theories, and presents Study 2, which investigated whether emotion-regulation strategies, disgust sensitivity (DS-R), and private body consciousness (PBC) moderate the effects found in Study 1. As predicted, disgust led to more left-wing economic attitudes, but this was only the case for high-PBC and high-DS-R participants. Chapter 4 presents Study 3, which replicated Study 2, and showed dissociations between the effects of disgust on economic and social attitudes. Chapter 5 presents a cross-sectional investigation (Study 4) that tested for associations between the predisposition to experience disgust and both social and economic attitudes. As predicted, core disgust and pathogen disgust were associated with left-wing economic attitudes and these effects applied only to British participants, and not non-British participants. Chapter 6 presents Study 5 – an experiment investigating the relationship between disgust and prejudiced attitudes towards outgroups. Induced disgust led to more prejudiced attitudes towards a novel group than both sadness and neutral emotion. Chapter 7 is focused on two self-conscious moral emotions: guilt and shame. Study 6, presented in this chapter, found a positive association between guilt proneness and left-wing economic attitudes, and a relationship between shame proneness and social-conservative attitudes. Study 7 failed to reveal causal relationships between incidental guilt and shame and political attitudes. Chapter 8 presents the general discussion addressing limitations, implications, and future research directions.
Allostasis of cerebral water: modelling the transport of cerebrospinal fluid
Keywords: poroelastic theory
fluid dynamics
normal pressure hydrocephalus
multiple network poroelastic theory

A validated model of water transport in the cerebral environment is both an ambitious and timely task; many brain diseases relate to imbalances in water regulation. From tumours to strokes, chronic or acute, transport of fluid in the brain plays a crucial role. The importance and complexity of the brain, together with the range of unmet clinical needs that are connected with this organ,make the current research a high-priority.
One of the most paradoxical cerebral conditions, hydrocephalus, serves as an excellent metric for judging the success of anymodel developed. In particular, normal pressure hydrocephalus (NPH) is a paradoxical condition with no known cure and existing treatments display unacceptably high failure rates. NPH is considered to be a disease of old age, and like many such diseases, it is related to a change in the transport of fluid in the cerebral environment. This complex system ranges from organ-level transport to cellular membrane channels such as aquaporins; through integrating it in a novel mathematical framework, we suggest that the underlying logic of treatment methods may be misleading.
By modelling the transport of cerebrospinal fluid (CSF) between the ventricular system, cerebral tissue and blood networks, we find that changes to the biophysical properties of the brain (rather than structural changes such as aqueduct obstruction) are capable of producing clinically relevant ventriculomegaly in the absence of any obstruction to CSF flowthrough the ventricular system. Specifically, the combination of increased leakiness and compliance of the capillary bed leads to the development of enlarged ventricles with a normal ventricular pressure, replicating clinical features of the presentation of NPH. These results, while needing experimental validation, imply that treatment methods like shunting, that are focussed on structural manipulation, may continue to fail at unacceptably high rates.
Pairing, paramagnetism and prethermalization in strongly correlated low-dimensional quantum systems
Keywords: Strongly Correlated Systems
Out-of-equilibrium quantum mechanics
paramagnetism
Quantum Quench
Condensed Matter Theory
superconductivity

Quasi-one-dimensional quantum models are ideal for theoretically exploring the physical phenomena associated with strong correlations. In this thesis we study three examples where strong correlations play an important role in the static or dynamic properties of the system.
Firstly, we examine the behaviour of a doped fermionic two-leg ladder in which umklapp interactions are present. Such interactions arise at special band fillings and can be induced by the formation of charge density wave order in an array of two-leg ladders with long-range (three-dimensional) interactions. For the umklapp which arises from the half-filling of one of the bands, we show that the low-energy theory has a number of phases, including a strong coupling regime in which the dominant fluctuations are superconducting in nature. These superconducting fluctuations carry a finite wave vector – they are the one-dimensional analogue of Fulde-Ferrell-Larkin-Ovchinnikov superconductivity.
In a second example, we consider a quantum spin model which captures the essential one-dimensional physics of CoNb2O6, a quasi-one-dimensional Ising ferromagnet. Motivated by high-resolution inelastic neutron scattering experiments, we calculate the dynamical structure in the paramagnetic phase and show that a small misalignment of the transverse field can lead to quasi-particle breakdown – a surprising broadening in the single particle mode observed in experiment.
Finally, we study the out-of-equilibrium dynamics of a model with tuneable integrability breaking. When integrability is broken by the presence of weak interactions, we show that the system relaxes to a non-thermal state on intermediate time scales, the so-called “prethermalization plateau”. We describe the approximately stationary behaviour in this regime by constructing a generalised Gibbs ensemble with charges deformed to leading order in perturbation theory. Expectation values of these charges are time-independent, but interestingly the charges do not commute with the Hamiltonian to leading order in perturbation theory. Increasing the strength of the integrability breaking interactions leads to behaviour compatible with thermalisation.
In each case we use a combination of perturbative analytical calculations and non-perturbative numerical computations to study the problem at hand.
Segmentation and analysis of vascular networks
Keywords: Markov Chain Monte Carlo
vascular segmentation
particle filter
vascular analysis
image segmentation

From a clinical perspective retinal vascular segmentation and analysis are important tasks in aiding quantification of vascular disease progression for such prevalent pathologies as diabetic retinopathy, arteriolosclerosis and hypertension. Combined with the emergence of inexpensive digital imaging, retinal fundus images are becoming increasingly available through public databases fuelling interest in retinal vessel research.
Vessel segmentation is a challenging task which needs to fulfil many requirements: the accurate segmentation of both normal and pathological vessels; the extraction of vessels of different sizes from large high contrast to small low contrast; minimal user interaction; low computational requirements; and the potential for application among different imaging modalities. We demonstrate a novel and significant improvement on an emerging stochastic vessel segmentation technique, particle filtering, in terms of improved performance at vascular bifurcations and extensibility. An alternative deterministic approach is also presented in the form of a framework utilising morphological Tramline filtering and non-parametric windows pdf estimation. Results of the deterministic algorithm on retinal images match those of state-of-art unsupervised methods in terms of pixel accuracy.
In analysing retinal vascular networks, an important initial step is to distinguish between arteries and veins in order to proceed with pathological metrics such as branching angle, diameter, length and arteriole to venule diameter ratio. Practical difficulties include the lack of intensity and textural differences between arteries and veins in all but the largest vessels and the obstruction of vessels and connectivity by low contrast or other vessels. To this end, an innovative Markov Chain Monte Carlo Metropolis-Hastings framework is formulated for the separation of vessel trees. It is subsequently applied to both synthetic and retinal image data with promising results.
Science collection, exhibition, and display in public museums in Britain from World War Two through the 1960s
Keywords: Science Museum
Festival of Britain
United Kingdom
UK
victoria &amp; albert
greenwich
education
planetarium
british
1951
museums
british museum
20th century
centre block
collections
twentieth century

Science and technology is regularly featured on radio, in newspapers, and on television, but most people only get ﬁrsthand exposure to ‘cutting-edge’ technologies in museums and other exhibitions. During this period, the Science Museum was the only permanent national presentation of science and technology. Thus, it is important to acknowledge the Museum’s history and the socio-political framework in which it operated. Understanding the delays in the Museum’s physical development is critical, as is understanding the gradual changes in the Museum’s educational provision, audience, and purpose. While the Museum was the main national exhibition space, the Festival of Britain in 1951 also provided a platform for the presentation of science and technology and was a statement of Britain’s place within the new post-War world. Speciﬁcally, within its narrative, the Festival addressed the relationship between the arts and the sciences and the inﬂuence of science and technology on daily life. Another example of the presentation of science was the quest for a planetarium in London - a story that involves the Science Museum, entrepreneurs, and Madame Tussauds. Comparing the Museum’s efforts with successful planetarium schemes isolates several of the Museum’s weaknesses - for example, the lack of consistent leadership and the lack of administrative and ﬁnancial freedom - that are touched on throughout the work. Since most of this history is unknown, this work provides a fundamental basis for understanding the Museum’s current position, for making connections and comparisons that can apply to similar problems at other institutions, and for learning lessons from the struggles that can, in turn, be applied to other institutions.
Weak cost automata over infinite trees
Keywords: automata theory
monadic second-order logic
cost functions
parity games

Cost automata are traditional finite state automata enriched with a finite set of counters that can be manipulated on each transition. Based on the evolution of counter values, a cost automaton defines a function from the set of structures under consideration to the natural numbers extended with infinity, modulo a boundedness relation that ignores exact values but preserves boundedness properties.
Historically, variants of cost automata have been used to solve problems in language theory such as the star height problem. They also have a rich theory in their own right as part of the theory of regular cost functions, which was introduced by Colcombet as an extension to the theory of regular languages. It subsumes the classical theory since a language can be associated with the function that maps every structure in the language to 0 and everything else to infinity; it is a strict extension since cost functions can count some behaviour within the input.
Regular cost functions have been previously studied over finite words and trees. This thesis extends the theory to infinite trees, where classical parity automata are enriched with a finite set of counters. Weak cost automata, which have priorities {0,1} or {1,2} and an additional restriction on the structure of the transition function, are shown to be equivalent to a weak cost monadic logic. A new notion of quasi-weak cost automata is also studied and shown to arise naturally in this cost setting. Moreover, a decision procedure is given to determine whether or not functions definable using weak or quasi-weak cost automata are equivalent up to the boundedness relation, which also proves the decidability of the weak cost monadic logic over infinite trees.
The semantics of these cost automata over infinite trees are defined in terms of cost-parity games which are two-player infinite games where one player seeks to minimize the counter values and satisfy the parity condition, and the other player seeks to maximize the counter values or sabotage the parity condition. The main contributions and key technical results involve proving that certain cost-parity games admit positional or finite-memory strategies.
These results also help settle the decidability of some special cases of long-standing open problems in the classical theory. In particular, it is shown that it is decidable whether a regular language of infinite trees is recognizable using a nondeterministic co-Büchi automaton. Likewise, given a Büchi or co-Büchi automaton as input, it is decidable whether or not there is a weak automaton recognizing the same language.
Interferometric spatio-temporal characterisation of ultrashort light pulses
Keywords: Optics
Femtosecond Science
Ultrafast Metrology
Interferometry
X-Ray Science
Attosecond science
Laser Science
Ultrafast Science

The main topic of this thesis is the development of novel diagnostics for the characterisation of infrared femtosecond and extreme-ultraviolet (XUV) attosecond pulses. High-resolution interferometric methods are applied to high harmonic radiation, both to measure the properties of the XUV light and to relate this information to the physics of the fundamental generation process. To do so, a complete high harmonic beamline has been built and optimised to enable the observation of strong signatures of the macroscopic response of the medium. The distinct spatial characteristics of long and short trajectories are studied, as well as the interference between them. An interferometric measurement allows the extraction of the atomic dipole phase, which gives direct access to the sub-cycle electron dynamics.
A major focus of this thesis is on the development of a novel method which simultaneously characterises two independent electric fields as a function of any degree of freedom in which it is possible to shear one of the beams. Since each field alternately takes the role of the reference to retrieve the other field, this technique is referred to as mutual interferometric characterisation of electric-fields (MICE). One of the key features of MICE is that no sheared but otherwise identical replica of the test pulse needs to be generated, which is a typical requirement of self-referencing techniques. Furthermore, no a priori information is needed for the reconstruction. The strength and the wide applicability of MICE are demonstrated using two fundamentally different examples. First, the temporal pulse profiles of two infrared femtosecond pulses are simultaneously reconstructed in a single laser shot. In the second demonstration, the MICE approach is used to simultaneously reconstruct the wavefronts of two high harmonic beams. Having this new technique at hand, the phase properties of the different quantum trajectories are compared.
All pulse characterisation techniques implicitly assume full coherence of the beam. This, however, is often not the case in practice, in particular when dealing with complex XUV light sources. Here the standard characterisation techniques fail to provide an accurate description of the electric field. Instead, the electric field must be seen as a statistical mixture of different contributions to the overall field. Here an interferometric experiment is first proposed and then performed involving multiple lateral shears to measure the two-point correlation function of high harmonic radiation. This directly provides information about the existence and the magnitude of partial coherence of high harmonics.
States’ international obligations to control private military & security companies
Keywords: human rights
iraq
afghanistan
state responsibility
attribution
mercenary
security
international humanitarian law
jurisdiction
military
privatization
blackwater

Tens of thousands of contractors work for private military and security companies (PMSCs) in armed conflicts around the world, often hired by states to fulfil functions that were once the exclusive domain of the armed forces. In this context, PMSCs have performed a wide range of activities including offensive combat, prisoner interrogation, military advice and training, armed security, intelligence and logistics.
The proliferation of PMSCs during the past two decades has challenged conventional conceptions of the state as the primary holder of coercive power in the international arena. Nonetheless, this Thesis argues that the traditional state-centred frameworks of international law remain vitally relevant to the regulation of private security activity in contemporary armed conflict. Three states are in a strong position to influence PMSCs in this context—the state that hires the PMSC, the state in which the company is based or incorporated, and the state in which the company operates—and this capacity for influence enables international law to regulate PMSC activities indirectly using these states as an intermediary.
This Thesis critically analyses the pertinent international obligations on these three categories of states and identifies the circumstances in which PMSC misconduct may give rise to state responsibility in each case. It also examines the recent practice of certain key states in order to evaluate their compliance with these obligations. By providing a clear and in-depth analysis of states' international obligations to control PMSCs in armed conflict, this Thesis may not only facilitate the assessment of state responsibility in cases of PMSC misconduct; it may also play an important prospective role in setting standards of conduct for states in relation to the private security industry. This in turn may encourage and assist states to develop their domestic laws and policies in order to improve overall PMSC compliance with international law.
The self-assembly of nucleic acid bases on metal and mineral surfaces
Keywords: Au (111)
STM
origin of life
RNA
self-assembly
adenine
molecular self-assembly
gold (111)
pyrite (100)
uracil
scanning tunneling microscopy
nucleic bases

The ability of RNA bases to self-assemble into larger structures is an important research area relevant to the origins of life. In the RNA helix the bases are arranged on a sugar-phosphate carcass but it has been suggested that the initial ordering could form on a flat surface. This thesis is an attempt to establish experimentally whether the complementary RNA bases, adenine and uracil, have the ability to self-assemble into large ordered structures when adsorbed on metal and mineral surfaces. The Au (111) surface was chosen as a preferred substrate as it is flat, relatively free of defects, chemically inert and reconstructs in a characteristic pattern of corrugation lines, which provide a reference for crystallographic directions. Six of the molecular phases shown were observed for the first time with molecular resolution and the possible two-dimensional arrangements of adenine and uracil molecules for these phases are proposed. The pure adenine and pure uracil structures have chiral unit cells and in the case of pure uracil alternating monochiral domains within the polychiral islands are created. Well-ordered intricate uracil-adenine bimolecular networks were also observed. The self-assembly of both uracil and adenine appears to be weakly influenced by the surface crystallography. The (100) surface of the mineral pyrite (FeS₂) was chosen as the alternative substrate as it is the most common face that occurs naturally in pyrite crystals. The experiments show the formation of small adenine and uracil crystals at the terrace edges. Neither uracil nor adenine were observed to form a monolayer on the surface of the terraces. The results of the experiments described in this thesis are very interesting in terms of establishing the possible mechanisms for creating regular chiral molecular networks and provide a useful insight into the role of surfaces in the processes of self-assembly of RNA bases.