VictorJuiz/thesis huggingface dataset:
Conflicts with jus cogens in international law
Keywords: inconsistency
jus cogens
sources of international law
normative conflicts
peremptory norms
conflicts

Jus cogens is a mysterious body of international law. It comprises legal standards which are thought to be superior to those in ordinary international law, namely, international treaties, customary international law, and general principles of law. The title of this study – ‘Conflicts with Jus Cogens in International Law’ – condenses its main aims. The study examines conflict-situations between jus cogens rules and rules of ordinary international law.
The study is divided into four Parts. Part I clarifies what jus cogens status means and how jus cogens rules are made. Part II analyses some of the different ways in which legal rules come into conflict with each other. I seek to push the boundaries of our understanding of legal conflict, and I also construct a typology of legal conflict. In Part III, I apply the analysis of conflict in Part II to the jus cogens context by identifying and classifying situations where rules of ordinary international conflict with jus cogens rules. Finally, Part IV explores the consequences of the conflicts with jus cogens which were identified in Part III. What we see is that the consequences of these conflicts are varied. Most strikingly, however, we find that in some cases jus cogens rules are being defeated by rules of ordinary international law. This challenges the orthodox thinking that jus cogens rules are straightforwardly superior to ordinary international law, in the sense that they always prevail in conflict-situations. But while the conclusion of the study may seem radical, it is informed by theoretical writing about law and about how rules conflict.
Ultimately, the study seeks to improve our understanding of jus cogens rules in international law, as well as the more general problem of how legal rules conflict with each other.
Underworld justice in Imperial China and its continuing influence in Hong Kong
Keywords: Legal Culture
Comparative Law
Hong Kong
China
Legal Pluralism

This thesis explores the imagery of underworld justice, and its associated beliefs and practices, as they developed throughout Chinese imperial history. Certain elements of the Chinese imperial legal system, including judges and trials, and laws and codes, were borrowed by the Daoists and applied to their construct of the afterlife. Underworld justice beliefs and practices flourished throughout China‘s imperial past, and are still influential to some devotees in today‘s Hong Kong. Among the various questions that are explored, this thesis examines the place of underworld justice in the legal consciousness, or everyday law, of the devotees in contemporary Hong Kong. There are two dimensions to this thesis: historical and empirical. In the historical part, I trace the development of underworld justice beliefs and practices in imperial China. I analyse some of the characteristics and rituals of underworld justice, and relate them to the imperial laws and procedures upon which they were modelled. Such tracing allows us to discern the considerable overlap between the imperial legal system and underworld justice beliefs and practices. In the empirical part, I present data gathered at mainly three City God temples in Hong Kong. Such data involve conversations with Daoist and Buddhist priests, temple keepers and devotees. The data gathered not only shed light on the general state of City God veneration in contemporary Hong Kong, but also the influence of underworld justice on the devotees‘ understanding of law. The data reveal that the studied devotees regard underworld justice, which administers the law of karma, as superior to the state legal system. Hence, underworld justice is not considered as an informal dispute resolution process alternative to that of the state, but as a mechanism that can intervene in court cases, due to its being more authoritative.
Quantifying collateral flow pathways in the brain
Keywords: Blood flow
Arterial spin labelling
Ischaemia
Collateral flow
Haemodynamics
MRI angiography
Cerebral autoregulation
circle of Willis

Ischaemic stroke is a major cause of death and disability worldwide. Cerebral autoregulation, which can be impaired during acute stroke, and collateral flow to brain tissue through the circle of Willis, both play a role in preventing tissue infarction. The configuration of the arterial circle varies between individuals. Thus, personalised modelling of the cerebral arterial network, to determine the potential for collateral flow, can be of significant value in the clinical context of stroke.
The interaction between autoregulation and collateral flow remains poorly understood. In this study, steady-state physiological models of the cerebral arterial network, including several common variants of the circle of Willis, were coupled to a spatially variable mathematical representation of cerebral autoregulation. The resulting model was used to simulate various arterial occlusions, as well as bilateral and unilateral impairment of autoregulation, in each structural variant. The work identified few circle of Willis variants that present either particularly high-risk or particularly low-risk of cerebral ischaemia. Instead it was found that most variants are dependent upon the bilateral function of autoregulation to facilitate collateral flow and preserve cerebral blood flows. When autoregulation was impaired unilaterally, downstream of an occlusion, blood flows in the contralateral hemisphere were preserved at the expense of the ipsilateral tissue at risk.
Arterial network models have in the past been personalised using structural, rather than functional, angiography measurements. This thesis presents a novel model-based method for absolute blood volume flow rate quantification in short arterial segments using dynamic magnetic resonance angiography data. The work also investigated the additional information that can be obtained from such functional angiography. The flow quantification technique was found to accurately estimate flows in shorter arterial segments than an existing technique. However, improvements to noise performance, and strategies for rejection of contaminating signals from overlapping vessels within the imaging plane, are required before the technique can be applied to personalised cerebral arterial network modelling.
Culinary civilization: the representation of food culture in Ford Madox Ford, Gertrude Stein and Virginia Woolf
Keywords: Civilization
Virginia Woolf
Domesticity
Transatlantic literature
Modernism
Food history
Gertrude Stein
Ford Madox Ford
Food culture

This thesis addresses the literary representation of food in the period from 1900 through 1945 in the work of Ford Madox Ford, Gertrude Stein and Virginia Woolf. Taking up nineteenth-century fascinations with sensual and aesthetic taste, these authors explore the implications of food preparation and consumption in Britain, America and France. They use representations of everyday culinary practices as a way to examine articulations of anxiety about the state of civilization, a fear that is amplified and altered by both World Wars. The thesis approaches the question of the significance of food to literary modernism in two ways. The first is a theoretical analysis of modernist ways of thinking about the dialectic between the concepts of civilization and barbarism. The second is grounded in material history, establishing the contexts and conditions of food culture in the first half of the twentieth century. Drawing on sociological thinking from Norbert Elias's conception of the civilizing process and Pierre Bourdieu’s theory of distinction, and using a combined methodology of close reading, biographical and historical analysis, I show that food acts as a lens for these authors' ideas about civil society and modernity.
My original contribution to knowledge is threefold. The first is my interpretation of 'culinary Impressionism' as an extension and repositioning of current scholarly thinking about Ford’s literary Impressionism. The second is my reading of Stein's and Toklas's jointly-authored cookbook draft as evidence of their collaboration. This forms the crux of my argument about Stein adapting domestic culinary techniques into her other writing. The third is in my chapter on Virginia Woolf. My original archival research shows that in A Room of One’s Own Woolf’s representation of the financial and culinary difference between men’s and women's dining in colleges at the University of Cambridge is justified and the material inequality was in fact worse than previously understood. I argue that the disparity in institutional food intensifies Woolf’s later reimagining of the term ‘civilization’ in Three Guineas. While drawing on the work of modernist studies scholars on modernism and the everyday, civilization, and food, my project is unique in demonstrating that food reflects modernist conceptions of civilization and barbarism. My thesis contributes to the understanding of transatlantic aesthetics and gendered productions of modernism by illuminating the centrality of agriculture, cookery, domestic work and institutional dining to modernist authors.
Investigating TGFβ signals in cell fate specification in the early mouse embryo
Keywords: lineage priming
extra-embryonic
TGFβ signalling
Bmp signalling
Smad2, Smad3
embryonic stem cells
mouse embryo
Nodal signalling
cell fate allocation

TGFβ signalling via Smad transcription factors is essential for axis patterning and subsequent cell fate specification during mammalian embryogenesis. However, the cellular and molecular mechanisms have been difficult to characterise in vivo due to early embryonic lethality of mouse mutants and redundant functional activities. Here I show that combined deletion of closely related Smad2 and Smad3 in mouse embryonic stem cells impairs induction of lineage specific gene expression during differentiation, while extra-embryonic gene expression is up-regulated. Preliminary data suggest that the underlying mechanism of this differentiation defect reflects the inability of Smad2/3-/- cells to establish lineage priming. Collectively, these findings identify novel downstream target genes controlled by Smad2/3 and an absolute requirement for Smad2/3 during embryonic differentiation. TGFβ signalling via Smad1 and Smad4 is essential for induction of the transcription factor Blimp1 required for primordial germ cell specification. The direct upstream regulators of Blimp1 are unknown, but T-box factors have recently been suggested to play a role. In a second project, I performed tissue- specific ablation of the T-box transcription factor Eomes as well as components of the TGFβ signalling pathway in either the visceral endoderm or the epiblast to examine tissue-specific functions for Blimp1 induction. I show that Eomes and Smad2 functions in the visceral endoderm as well as Eomes function in the epiblast are dispensable for Blimp1 induction, but rather are required to restrict Blimp1 induction to posterior epiblast cells. In contrast, epiblast-specific Smad4 or Smad1 mutants fail to robustly induce Blimp1 in the epiblast. My preliminary analysis suggests that competence to induce primordial germ cell fate is dependent on the interplay of Smad2/Eomes functions in the visceral endoderm and Smad1/4 functions in the epiblast. Collectively, this thesis provides insight into the transition from pluripotency to cell fate specification in the mammalian embryo that is impossible to obtain from human embryos in vivo.
Mechanisms underlying apathy in health and Parkinson's disease
Keywords: Parkinson's disease
Reward
Motivation
Pupillometry
Saccades
Dopamine
Apathy

Apathy or lack of motivation is increasingly recognized to be a major factor affecting quality of life and prognosis in many neurological conditions. It is particularly prevalent in Parkinson’s disease, impacting on every disease stage, including de novo cases, and has been reported to affect up to 70% of cases. Despite the pervasiveness of apathy, challenges remain in its detection, clinical assessment and treatment. Several lines of evidence have implicated fronto-striatal reward related neural pathways in the genesis of apathy but the precise processes remain to be fully explained.
This thesis examines the potential mechanisms of apathy using Parkinson’s disease as a model to study the condition. Novel oculomotor tasks that used eye movement and pupillary responses were developed to help assess if insensitivity to incentives could be an underlying component of apathy. This was examined in healthy young and elderly participants as well as in patients with Parkinson’s disease. Patients were tested both ON and OFF their normal dopaminergic medication so that the effect of dopamine could be assessed and the association with apathy determined. This was also performed in a pharmacological study in young participants with the use of Haloperidol, a dopaminergic D2-selective antagonist.
Insensitivity to rewards modulated by dopamine was regarded to be a contributory mechanism of apathy in Parkinson’s disease and also applicable to general mechanisms of motivation in healthy populations.
Phenotyping cellular motion
Keywords: collective motion
superpixels
temporal dynamic graphs

In the development of multicellular organisms, tissue development and homeostasis require coordinated cellular motion. For example, in conditions such as wound healing, immune and epithelial cells need to proliferate and migrate. Deregulation of key signalling pathways in pathological conditions causes alterations in cellular motion properties that are critical for disease development and progression, in cancer it leads to invasion and metastasis. Consequently there is strong interest in identifying factors, including drugs that affect the motion and interactions of cells in disease using experimental models suitable for high-content screening. There are two main modes of cell migration; individual and collective migration. Currently analysis tools for robust, sensitive and comprehensive motion characterisation in varying experimental conditions for large extended timelapse acquisitions that jointly considers both modes are limited.
We have developed a systematic motion analysis framework, Motion Sensing Superpixels (MOSES) to quantitatively capture cellular motion in timelapse microscopy videos suitable for high-content screening. MOSES builds upon established computer vision approaches to deliver a minimal parameter, robust algorithm that can i) extract reliable phenomena-relevant motion metrics, ii) discover spatiotemporal salient motion patterns and iii) facilitate unbiased analysis with little prior knowledge through unique motion ‘signatures’. The framework was validated by application to numerous datasets including YouTube videos, zebrafish immunosurveillance and Drosophila embryo development. We demonstrate two extended applications; the analysis of interactions between two epithelial populations in 2D culture using cell lines of the squamous and columnar epithelia from human normal esophagus, Barrett’s esophagus and esophageal adenocarcinoma and the automatic monitoring of 3D organoid culture growth captured through label-free phase contrast microscopy. MOSES found unique boundary formation between squamous and columnar cells and could measure subtle changes in boundary formation due to external stimuli. MOSES automatically segments the motion and shape of multiple organoids even if present in the same field of view. Automated analysis of intestinal organoid branching following treatment agrees with independent RNA-seq results.
Cybersecurity and non-state actors: a historical analogy with mercantile companies, privateers, and pirates
Keywords: International Relations
Cyber Operations
Semi-State Actors
Non-State Actors
Cybersecurity
Cyber(in-)security

The thesis investigates how the historical analogy to mercantile companies, privateers, and pirates between the 16th and 19th century can elucidate the relationship between non-state actors and states in cyber(in-)security, and how such an application changes our understanding of cyber(in-)security. It contributes to a better integration of non-state actors into the study of cyber(in-)security and international security by clarifying the political challenges raised by the interaction between these players and states.
Drawing on the literature of non-state armed actors, the thesis defines a spectrum of state proximity to develop an analytical framework categorizing actors as state, semi-state, and non-state. The historical investigation utilizes primary and secondary sources to explore three periods in British naval history: the late 16th, late 17th, and mid-19th centuries. A comparison of the two security domains – the sea and cyberspace – identifies the pre-18th century periods as the most useful analogues for cyber(in-)security.
The thesis evaluates the analogy by conducting empirical case studies. First, the case of the attacks against Estonia (2007) and three criminal court cases against Russian hackers (2014/2017) examine the analogy to pirates and privateers. Second, the analogy to mercantile companies focuses on the attacks against Google (2009), the attacks against Sony Pictures Entertainment (2014), and the collaboration between large technology companies and Five-Eyes signals intelligence agencies.
The thesis makes three main claims: first, the analogy to piracy and privateering provides a new understanding of how state proximity is used politically by attackers and defenders, and offers lessons for understanding attribution in cyberspace. Second, the longevity of historical privateering sheds light on the long-term risks and rewards of state collaboration with cyber criminals, and offers insight into the political constitution of cyber(in-)security. Third, the mercantile company lens improves our understanding of how cooperative and conflictive relations between large technology companies and states influence cyber(in-)security.
Layers of modality
Keywords: modal verbs
Croatian

Much of the literature on modality focuses, at least implicitly, on the occurrence of single modal auxiliaries. However, cross-linguistically, modal auxiliaries can co-occur with one another, but under interesting restrictions. This thesis examines layered modal constructions and the semantic restrictions under which they combine. For instance, in languages such as Croatian, where double modal constructions are part of the standard, data shows that while some combinations are acceptable, others are not. Therefore, the aim of this thesis is to identify these semantic restrictions and to explain the rationale that motivates them.
To answer these questions, a systematic study of four possible combinations (epis- temics embedding epistemics, epistemics embedding non-epistemics, non-epistemics embedding non-epistemics, and non-epistemics embedding epistemics) was carried out. The data shows that the first three groups are, in general, acceptable to native speakers, while the last one is not. Further to that, the data shows that within the non-epistemic + non-epistemic group there seem to be further restrictions. The result was a hierarchical analysis that is based on modal force and flavour. With respect to force, it is shown in Chapter 4 that necessity embeds possibility, crucially, only when two of the same flavour combine. In terms of flavour, the data shows that epistemics can embed non-epistemics, while in the non-epistemic group priority embeds the circumstantial group in which pure possibility embeds ability and disposition, respectively. This analysis carries some important implications for the traditional categorisation of modal flavours which is discussed in Chapter 4. Finally, in Chapter 5 I also discuss the possible rationale behind the hierarchy and the compositional nature of DMCs. It is concluded that the hierarchy should not be taken as a merely descriptive generalisation, but rather as an analysis that is predictable on the basis of the conceptual and logical reality of human language.
Segregation-assisted creep in nickel-based superalloys: experiments, theory and modelling
Keywords: creep

Mid-temperature creep deformation in the range of 600 to 850°C is assuming greater importance in Ni-based superalloys. This is because the design operating temperature of the combustion cycle is increasing as the new generations turbofan engines become more efficient. The temperature at the rim of turbine disks and the root of turbine blades can be in this critical range of temperatures for significant portions of the mission cycle, leading to a complex time-dependent mode of plasticity called "microtwinning"'. Unfortunately this kind of coupled displacive-diffusive deformation mechanism is not yet well understood, and even the range of temperatures and stresses where microtwinning occurs is not clearly defined.
This work explores the fundamentals of this phenomenon, from the kinetics of microtwinning to its influence on the mechanical behaviour of the material. To achieve this objective, coupled computational-experimental studies have been carried out. First, the contribution of microtwinning mechanism to the creep deformation of a single crystal superalloy is studied. The accumulated creep strain computed from quantitative stereology of the tested samples supports the role of this mechanism in conferring plastic deformation. Second, the chemical composition of the microtwins is analysed by means of atomic-resolution characterisation techniques (APT and TEM). Segregation of γ'-stabilisers to the growing faults is found to be crucial for the understanding of the creep mechanisms in this range of temperatures. Third, a model for diffusion-controlled growth of microtwins is proposed and used to recover the experimental creep strain rates. This then provides the basis for a thermodynamically consistent constitutive model developed on the basis of crystal plasticity theory. The constitutive model is subsequently implemented into a finite element code to study the activation of the different plastic mechanisms within single crystal and polycrystalline aggregates depending on the crystal orientation. With the support of this model, a relation between the rotations of the crystal and the creep life of the different crystal orientations is established. The numerical and experimental results ultimately reveal the critical role of the microtwinning on the asymmetric behaviour of the alloy and thus, its influence on the mechanical performance.