VictorJuiz/thesis huggingface dataset:
Development and optimisation of three-dimensional freeze-dried collagen-based scaffolds
Keywords: tissue engineering
3D
freeze-drying
scaffolds

Three-dimensional collagen/chitosan scaffolds fabricated by freeze-drying technique in 96-well polystyrene and PDMS plates were optimized during this study. Surface tension is, by and large, one of the most limiting factors in fabricating freeze-dried scaffolds in small format well plates. Traditionally, bowl-shaped top surfaces of collagen/chitosan scaffolds were common in polystyrene 96-well plate; whereas for PDMS 96-well plate, dome-shaped surfaces were formed. These surface tension phenomena are not desirable in cell studies especially during initial cell seeding. A combination of surface treatment and change of freeze-drying regime were developed to mitigate the surface tension problem in PS and PDMS 96-well plates respectively. Collagen/chitosan scaffolds of varying concentration and composition were experimented in both polystyrene and PDMS 96-well plates. Thin water film treatment with UV cross-linking was successfully used to eliminate meniscus in PS well plates; pre-cooling, on the other hand, was utilised to treat scaffold solutions in PDMS well plates. The resultant matrices all had flat top surfaces and average thickness of 1 mm. As expected, scaffolds with lower overall polymer concentration or, from a compositional perspective, scaffolds with high chitosan content generally had larger pores. Microscopic observation by multi-photon microscope was performed and chemical analyses were conducted to characterize the surface-treated scaffolds. In addition, scaffolds were tested in vitro using DLD-1 cells, hMSCs and fibroblasts for their biological performance. The purpose of this study was to address the problem of using small format culture wells for the fabrication of freeze-dried collagen-based scaffolds for studies of cell growth in 3D culture and in microfluidic perfusion bioreactors.
Local decision-making in multi-agent systems
Keywords: distributed decision-making
multi-agent systems

This thesis presents a new approach to local decision-making in multi-agent systems with varying amounts of communication. Here, local decision-making refers to action choices which are made in a decentralized fashion by individual agents based on the information which is locally available to them.
The work described here is set within the multi-agent decision process framework. Unreliable, faulty or stochastic communication patterns present a challenge to these settings which usually rely on precomputed, centralised solutions to control individual action choices.
Various approximate algorithms for local decision-making are developed for scenarios with and without sequentiality. The construction of these techniques is based strongly on methods of Bayesian inference. Their performance is tested on synthetic benchmark scenarios and compared to that of a more conservative approach which guarantees coordinated action choices as well as a completely decentralized solution. In addition, the method is applied to a surveillance task based on real-world data.
These simulation results show that the algorithms presented here can outperform more traditional approaches in many settings and provide a means for flexible, scalable decision-making in systems with varying information exchange between agents.
A mediaeval court physician at work: Ibn Jumay''s commentary on the Canon of Medicine
Keywords: Islamicate Medicine
Ibn Sina
Mediaeval Cairo
Jewish Physicians
Ibn Jumay
twelfth-century
Avicenna
Mediaeval Islamic Medicine
Dissection
Anatomy
Islamic Medicine

Ibn Jumay''s (d. c. 594/1198) commentary on the Canon of Medicine by Ibn S&imacr;n&amacr; (d. 428/1037) occupies an important place in the history of medicine for it is the first Canon commentary written by a physician and thus stands at the start of a tradition extending over 500 years. In addition, it is a so-far neglected source for our understanding of mediaeval Islamic medicine. The present thesis analyses the commentary with the aims of (1) determining the methods by which the court physician composed his treatise and (2) understanding why Ibn Jumay' undertook to prepare a commentary on one of the most thorough medical compendia of the middle ages.
Chapter One presents the biography of Ibn Jumay', reveals that his religion had little impact on his writings and surveys his library which played a pivotal role in the composition of the commentary. Chapter Two investigates Ibn Jumay''s methodology in the entire commentary; it reveals that with his philological and source-critical methods Ibn Jumay' wanted to establish an authoritative reading of the Canon and to demonstrate the high degree of his erudition. Chapter Three focuses on selected passages in the commentary in form of three case studies. Ibn Jumay''s comments on anatomy/dissection, assorted materia medica and headaches demonstrate the court physician’s reverence for ancient authorities and his quest to revive and refine their teachings. Chapter Four contextualises Ibn Jumay''s methods and agenda by comparing them to those of other relevant scholars of the twelfth and thirteenth centuries.
The thesis concludes by arguing that Ibn Jumay''s commentary was part of his revival of the art of medicine and his attempt to gain power in the medical tradition by attaching his name to one of the greatest scholars of his time — the ra'&imacr;s Ibn S&imacr;n&amacr;.
From bilateralism to Cold War conflict : Pakistan's engagement with state and non-state actors on its Afghan frontier, 1947-1989
Keywords: Jihad
Cold War
Mujahidin
Bilateral Relations
Pakistan
Pashtunistan
South Asian History
Soviet Invasion
Insurgency
Afghanistan

The purpose of this thesis is to assess Pakistan’s relationship with Afghanistan before and after the Soviet invasion of Afghanistan in 1979. I argue that the nature of the relationship was transformed by the region becoming the centre of Cold War conflict, and show how Pakistan’s role affected the development of the mujahidin insurgency against Soviet occupation.
My inquiry begins by assessing the historical determinants of the relationship, arising from the colonial legacy and local interpretations of the contested spheres of legitimacy proffered by state, tribe and Islam. I then map the trajectory of the relationship from Pakistan’s independence in 1947, showing how the retreat of great power rivalry following British withdrawal from the subcontinent allowed for the framing of the relationship in primarily bilateral terms. The ascendance of bilateral factors opened greater possibilities for accommodation than had previously existed, though the relationship struggled to free itself of inherited colonial disputes, represented by the Pashtunistan issue. The most promising attempt to resolve the dispute came to an end with the communist coup and subsequent Soviet invasion, which subsumed bilateral concerns under the framework of Cold War confrontation. Viewing the invasion as a major threat, Pakistan pursued negotiations for Soviet withdrawal, aligned itself with the US and gave clandestine support to the mujahidin insurgency. External support enhanced mujahidin military viability while exacerbating weaknesses in political organization and ideology. Soviet withdrawal in 1989 left an unresolved conflict. Faced with state collapse and turmoil across the border, heightened security concerns following loss of US support, and intensified links among non-state actors on both sides of the frontier, the Pakistan government drew on its recently gained experience of working through non-state actors to attempt to maintain its influence in Afghanistan. There would be no return to the relatively stable state-state ties prevailing before 1979.
Defining the neural correlates of pain and analgesia in health and disease
Keywords: FMRI
ASL
tdcs
pain
neuroimaging
central sensitisation
phantom limb pain
analgesia

Chronic neuropathic pain affects up to 8% of the United Kingdom population and is a difficult condition to manage. It is established and maintained through many mechanisms, including central sensitisation (CS) in the spinal cord and brainstem. Neuropathic pain manifests as spontaneous pain, sensory loss and evoked hypersensitivity. The development of novel treatments for neuropathic pain is challenging, in part due to inadequate experimental models of clinically relevant pain. The use of functional magnetic resonance imaging (fMRI) techniques for imaging acute and increasingly tonic states enables the assessment of the neural correlates of evoked hypersensitivity and persistent pain, with the goal of developing appropriate biomarkers to test new therapies. This thesis develops novel techniques for the assessment of ongoing pain states and their modulation by therapies.
We first identified a suitable human experimental model of CS using topical capsaicin, and an fMRI pipeline for the investigation of supraspinal involvement in pain hypersensitivity. In a placebo-controlled study, we then demonstrated the improved sensitivity of fMRI above subjective reports in detecting the efficacy of a known analgesic as compared to an ineffective active compound in a small cohort. To translate this to the more clinically relevant symptom of spontaneous pain, we developed and validated the use of a multi-inversion time pseudo-continuous arterial spin labelling (ASL) imaging and analysis pipeline for the neural assessment of tonic states and the absolute quantification of cerebral blood flow (CBF).
Current evidence from structural and functional studies suggests a direct role for the posterior insula cortex in the encoding of nociception and pain. Using the ASL pipeline, we found that only a CBF change in the posterior insula region was correlated with the changing perception of persistent capsaicin-induced pain, and in a separate experiment showed that suppression of CBF in this region by gabapentin was related to the drug's suppression of subjective pain perception. We also demonstrated in a cohort of phantom limb patients that pain relief resulting from transcranial direct current stimulation of the deprived sensorimotor cortex is neurally represented by a decrease in posterior insula CBF.
In a separate study, we showed that baseline CBF in the periaqueductal grey can predict individuals who are most vulnerable to pain and hypersensitivity following the induction of capsaicin-related CS.
Taken together, these findings suggest that fMRI can be used as a tool to assess the efficacy of established and novel analgesics, with the midbrain reticular formation and posterior insula cortex being prime candidates as biomarkers of CS mechanisms and persistent pain respectively. Relatedly, ASL-fMRI may also be an effective technique for evaluating individuals' susceptibility to pain following inflammation or injury.
A millimeter unilateral finline SIS mixer with a wide IF bandwidth 
Keywords: SIS tunnel junction
SIS mixer

Superconductor-Insulator-Superconductor (SIS) tunnel junction mixers are now commonly used in as- tronomical receivers at (sub)millimeter wavelengths because of their superb sensitivity, high dynamic range and stability of operation. Niobium SIS mixers operating at frequencies well below the super- conducting gap (∼680 GHz) have already achieved quantum limited sensitivity. Therefore to further enhance the receiver sensitivity, increasing the Intermediate Frequency (IF) bandwidth of SIS mixers has became crucial. This thesis focuses on the theoretical modeling, design and experimental verifi- cation of Nb SIS mixers operating around 230 GHz with a wide IF bandwidth of 1–15 GHz. These mixers were designed for a single baseline heterodyne interferometer (GUBBINS), which is being built to observe the Sunyaev-Zel’dovich effect in the Cosmic Microwave Background. The combination of wide IF bandwidth SIS mixers and complex analogue correlators will allow GUBBINS to feature high surface brightness sensitivity, that helps to distinguish the weak SZ effect from the background noise. The SIS mixer detector system was assembled inside the GUBBINS cryostat together with the IF electronics and RF/LO optical systems. Low noise temperatures of around 71 K were then measured in the GUBBINS system.
The Nb SIS mixer we have developed uses a unilateral finline and fully integrated planar circuits deposited on a silicon substrate, to couple the electromagnetic radiation from the waveguide into the SIS junction. The finline mixer allows a broad-band RF coupling, an easy integration of the on-chip planar circuits and an easy-to-fabricate mixer block. To achieve a wide IF bandwidth, the output impedance of the SIS mixer was well matched to the input impedance of the amplifier by a multi-stage microstrip circuit. Additionally, the planar circuit of the SIS mixer was also designed to have a small lumped inductance and capacitance. The SIS mixer chip was extensively simulated by rigorous electromagnetic software (HFSS) and the S-parameter was exported to a quantum mixing package SuperMix to produce a full-wave model of the mixer. Experimental testing yielded a best noise temperature of 50 K with an average noise temperature of 75 K over an RF bandwidth of 160 GHz– 260 GHz. We have performed thorough experimental and computational investigation of the IF system in particular the constraints on the bandwidth caused by the lumped element capacitance of the mixer chip and the matching of the output impedance of the mixer to the IF amplifier. Our conclusion is that a bandwidth of 1–15 GHz could be achieved using our mixer design, subject to the performance of the amplifier. Finally, a variable temperature load system was successfully developed and tested inside the cryostat, to avoid the losses from the room-temperature optics. We have showed that the noise temperature of the SIS detector could be reduced by as much as 15 K by testing the mixer using a variable temperature load inside the cryostat.
Understanding the role of oxidation in bonding of aluminium alloys
Keywords: oxidation

The main aim of this work is to study the bonding behaviour of Al alloys as a function of temperature, time and processing conditions from a perspective of oxidation so as to gain a comprehensive knowledge of the oxidation issues during processing and to design better bonding approaches for different alloy systems.
Two major parts of work have been carried out during the study: (a) the use of a stacking approach and a double pouring approach to potentially join two Al alloys and their effectiveness are assessed; and (b) a precise investigation of the oxidation mechanisms for Al-Cu and Al-Mg alloys using a combination of theoretical analysis and experimental characterization.
The project started with the use of a stacking approach to try to bond two stacked Al alloys. The stacked sample can be viewed as a bi-metal which has an oxide bi-film layer at the bond interface. It was found that the bi-film layer was a physical barrier preventing direct metallic bonding. How this bi-film layer evolves during the bonding process was then investigated.
The work then moved on to investigate the oxidation mechanisms of Al-Cu alloys and Al-Mg alloys in greater detail. The thermodynamics, kinetics of oxidation, chemistry and morphology of the oxide scale were particularly studied. Briefly speaking, in the case of the Al-Cu-O2 system, the oxidation proceeds in the order of amorphous γ-Al2O3 - to - crystalline γ-Al2O3 - to - α-Al2O3; in the case of the Al-Mg-O2 system, the oxidation proceeds as amorphous γ-Al2O3 to MgO to MgAl2O4 and the morphology of the oxide scale develops from a protective layer to a porously structured composite layer.
A double pouring approach was finally developed to bond Al and Al-5Cu but the method has still not been perfected due to the formation of bi-film defects along the bond interface. Induction melting, squeeze casting, and extrusion bonding were therefore studied as an attempt to reduce the harmful effect of bi-film defects. Although all of the approaches exhibit some limitations, they have potential for future development.
Active colloids and polymer translocation
Keywords: swimmers
polymer dynamics
active colloids
simulation
stochastic sensing
colloids
phoresis
polymer translocation
fokker-planck equation
langevin equation

This thesis considers two areas of research in non-equilibrium soft matter at the mesoscale.
In the first part we introduce active colloids in the context of active matter and focus on the particular case of phoretic colloids. The general theory of phoresis is presented along with an expression for the phoretic velocity of a colloid and its rotational diffusion in two and three dimensions. We introduce a model for thermally active colloids that absorb light and emit heat and propel through thermophoresis. Using this model we develop the equations of motion for their collective dynamics and consider excluded volume through a lattice gas formalism. Solutions to the thermoattractive collective dynamics are studied in one dimension analytically and numerically. A few numerical results are presented for the collective dynamics in two dimensions. We simulate an unconfined system of thermally active colloids under directed illumination with simple projection based geometric optics.
This system self-organises into a comet-like swarm and exhibits a wide range of non- equilibrium phenomena. In the second part we review the background of polymer translocation, including key experiments, theoretical progress and simulation studies. We present, discuss and use a common model to investigate the potential of patterned nanopores for stochastic sensing and identification of polynucleotides and other heteropolymers. Three pore patterns are characterised in terms of the response of a homopolymer with varying attractive affinity. This is extended to simple periodic block co-polymer heterostructures and a model device is proposed and demonstrated with two stochastic sensing algorithms. We find that mul- tiple sequential measurements of the translocation time is sufficient for identification with high accuracy. Motivated by fluctuating biological channels and the prospect of frequency based selectivity we investigate the response of a homopolymer through a pore that has a time dependent geometry. We show that a time dependent mobility can capture many features of the frequency response.
‘Dark, mysterious, and undocumented’: the middlebrow fantasy and the fantastic middlebrow
Keywords: middlebrow
fantastic literature
twentieth-century literature
spinsters
sexuality

The concept of ‘middlebrow’ literature in the twentieth century, which received minimal critical attention from the Leavises onwards, has recently become a site of literary and sociological interest, especially regarding the interwar period. This thesis considers the ways in which a corporate middlebrow identity, amongst an intangible community of like-minded readers, was affected by a popularity of the fantastic in the 1920s and 1930s. This subgenre, which I term the ‘domestic fantastic’ (in which one or more elements of the fantastic intrude into an otherwise normalised domestic world) allowed middlebrow authors and readers to focalise and interrogate anxieties affecting the status of the home and its inhabitants which were otherwise either too taboo or, conversely, too well-worn for a traditional, non-fantastic examination. This fantastic vogue was largely initiated by the success of David Garnett’s metamorphosis novel Lady Into Fox (1922), which prepared the way for the other novels discussed in this thesis, predominantly Sylvia Townsend Warner’s Lolly Willowes (1926), Elinor Wylie’s The Venetian Glass Nephew (1926), Ronald Fraser’s Flower Phantoms (1926), Edith Olivier’s The Love-Child (1927), John Collier’s His Monkey Wife (1930) and Green Thoughts (1932), and Frank Baker’s Miss Hargreaves (1940). Through the lenses of metamorphosis, creation, and witchcraft, these novels respond to and reformulate contemporary debates concerning sexuality in marriage, childlessness, and autonomous space for unmarried women. The ‘middlebrow fantasy’ of the stable, idealised home was being revealed as untenable, and the fantastic responded. During the interwar years, when assessments of British society were being widely recalibrated, the domestic fantastic was a subgenre which produced a select but significant range of novels which (whether playful or poignant, hopeful or tragic, nostalgic or progressive) provided the means for both author and reader to interrogate and comment upon the most pervading middle-class social anxieties, in unusual and revitalising ways.
Religious autonomy and the personal law system
Keywords: religious arbitration
personal law
religious tribunals
personal status
religious freedom
law and religion
India
multiculturalism
South Asia

This thesis examines the Indian system of personal laws (‘the PLS’), under which the state applies a version of religious doctrine to the family matters of citizens whom it identifies as belonging to different religious groups. There has been a lengthy and persistent debate over the PLS, particularly in relation to its discriminatory effects upon women. However, another problem with the PLS has been little commented-upon. Supporters of the PLS emphasise its positive impact on religious freedom to such an extent that there is a pervasive assumption that the PLS is, indeed, good for religious freedom. But there has been surprisingly little critical assessment of the truth of this claim in either academic or political debates. This thesis, a work of applied normative legal theory, attempts to fill this important gap in the literature on the PLS. The thesis addresses the question of how the PLS affects one conception of religious freedom, namely religious autonomy. Its principal findings are that the PLS interferes with the religious autonomy of those subject to it by affecting their religious options (by interfering with their freedom from religion and their freedom to practice religion) and by harming their self-respect (by discriminating on the grounds of sex and religion, and by misrecognising their religious identities). Furthermore, the thesis finds that the PLS cannot be defended in the name of religious autonomy based on the possibility of exit from the system, the advantage of having the ‘option of personal law’, the power it gives people to bind their future selves, the expressive potential of the personal laws, the contribution it makes to membership in a religious community, the contribution it makes to religious group autonomy, or the recognition or validation it provides for religious identities. These conclusions imply that concerns relating to religious autonomy constitute an important set of objections to the PLS. The thesis then considers several reform proposals, including certain modifications of the PLS, a move towards a millet system, ‘internal’ reform of individual personal laws and the introduction of a Uniform Civil Code. It particularly focusses on one reform possibility – religious alternative dispute resolution – which has not been considered closely in the Indian context.