VictorJuiz/thesis huggingface dataset:
Dynamic spectrum sharing for future wireless communications
Keywords: wireless communications
performance analysis
dynamic spectrum access
Markov chain

The spectrum has become one of the most important and scarce resources for future wireless communications. However, the current static spectrum policy cannot meet the increasing demands for spectrum access. To improve spectrum efficiency, dynamic spectrum access (DSA) attempts to allocate the spectrum to users in an intelligent manner. Cognitive radio (CR) is an enabling technology for DSA, and can maximize spectrum utilization by introducing unlicensed or secondary users (SUs) to the primary system. The key component of DSA is dynamic spectrum sharing (DSS), which is responsible for providing efficient and fair spectrum allocation or scheduling solutions among licensed or primary users (PUs) and SUs. This thesis focuses on the design of efficient DSS schemes for the future wireless communication networks.
Firstly, based on the coordinated DSS model, this thesis proposes a heterogeneous-prioritized spectrum sharing policy for coordinated dynamic spectrum access networks. Secondly, based on the uncoordinated DSS model, a novel partial spectrum sharing strategy and the cross-layer optimization method have been proposed to achieve efficient spectrum sharing between two licensed networks. Then, a hybrid strategy which combines the overlay and underlay schemes is proposed under uncoordinated DSS model. The proposed analytical methods can provide efficient and accurate modeling to predict the behaviors of the PUs and SUs in DSS systems. This thesis presents the performance prediction of the proposed novel DSS schemes that achieve efficient spectrum sharing for coordinated and uncoordinated future wireless networks.
The role of catechol-O-methyltransferase (COMT) in hippocampal function
Keywords: hippocampus
dopamine
COMT
noradrenaline
schizophrenia
Catechol-O-methyltransferase

Catechol-O-methyltransferase (COMT) metabolises catechol-containing compounds, including dopamine. The aim of this thesis was to investigate whether COMT is involved in hippocampal function. This thesis also explored the role of functional polymorphisms within the COMT gene in the pathogenesis of schizophrenia and schizophrenia-related phenotypes.
First, as part of a study investigating the role of COMT in schizophrenia, human hippocampal COMT mRNA levels were shown to be neither altered in schizophrenia or bipolar disease, nor affected by COMT genotype. Hence, functional COMT polymorphisms do not appear to operate by altering gross COMT mRNA expression. Importantly, this study showed that COMT is expressed in the human hippocampus.
Second, the role of COMT in hippocampal neurochemistry was explored by studying the effect of pharmacological COMT inhibition on catecholamines and metabolites in rat hippocampal homogenates, and extracellularly, using microdialysis. Both demonstrated that COMT modulates hippocampal dopamine metabolism. Thus, hippocampal COMT is of functional significance with respect to dopamine.
Third, the effect of COMT inhibition on hippocampus-dependent behaviour was investigated. The results suggested a memory-enhancing effect of pharmacological COMT inhibition on hippocampus-dependent associative and non-associative forms of short-term memory in rats. In contrast, acute COMT inhibition appeared to have no effect on behavioural correlates of ventral hippocampal function i.e. anxiety-like behaviour.
In summary, the expression of COMT mRNA in the human hippocampus, as well as the effect of COMT inhibition on rat hippocampal neurochemistry and hippocampus-dependent behaviour provide evidence for a functional role of COMT in the hippocampus. Moreover, changes in COMT activity alter hippocampal dopamine metabolism, which could be a potential mechanism for the role of COMT in hippocampus-dependent short-term memory.
Studying protein-DNA interactions in vitro and in vivo using single-molecule photoswitching
Keywords: Fluorescence microscopy
Escherichia coli
Fluorescence Resonance Energy Transfer
DNA-Binding Proteins

Protein-DNA interactions govern the fundamental cellular processes of DNA replication, transcription, repair, and chromosome organisation. Despite their importance, the detailed molecular mechanisms of protein-DNA interactions and their organisation in the cell remain elusive. The complexity of molecular biology demands new experimental concepts that resolve the structural and functional diversity of biomolecules.
In this thesis, I describe fluorescence methods that give a direct view on protein-DNA interactions at the single-molecule level. These methods employ photoswitching to control the number of active fluorophores in the sample. Forster Resonance Energy Transfer (FRET) measures the distance between a donor and an acceptor fluorophore to report on biomolecular structure and dynamics in vitro. Because a single distance gives only limited structural information, I developed "switchable FRET" that employs photoswitching to sequentially probe multiple FRET pairs per molecule. Switchable FRET resolved two distances within static and dynamic DNA constructs and protein-DNA complexes. Towards application of switchable FRET, I investigated aspects of the nucleotide selection mechanism of DNA polymerase.
I further explored application of single-molecule imaging in the complex environment of the living cell. Photoswitching was used to resolve the precise localisations of individual fluorophores. I constructed a super-resolution fluorescence microscope to image fixed cellular structures and track the movement of individual fluorescent fusion proteins in live bacteria. I applied the method to directly visualise DNA repair processes by DNA polymerase I and ligase, generating a quantitative account of their repair rates, search times, copy numbers, and spatial distribution in the cell. I validated the approach by tracking diffusion of replisome components and their association with the replication fork. Finally, super-resolution microscopy showed dense clusters of SMC (Structural Maintenance of Chromosomes) protein complexes in vivo that have previously been hidden by the limited resolution of conventional microscopy.
Positive sum reciprocal engagement between China's grassroots NGOs and the local state
Keywords: local government
NGOs
China
development

This thesis explores state-society relations in China by focusing on the interactions between grassroots NGOs and local government departments. It presents the notion of positive-sum reciprocal engagement as one form of relationship that can emerge between the state and social organizations. Such engagement can be characterized as a dynamic and interactive process implying proximity, communication, joint action, mutual influence, mutual benefit and mutual empowerment, resulting in added value for society.
Drawing on fieldwork carried out in six rural or semi-rural Chinese localities, including interviews and questionnaires with local government departments and indigenous grassroots NGOs, this study seeks to identify the conditions under which positive-sum reciprocal engagement is likely to emerge. It finds that the presence of reformist officials, the strengthening of NGO capacity in framing issues to open social spaces and to engage in effective action while communicating the results of such action are particularly important to establishment of reciprocal engagement. Significant structural or contextual factors include positive associational experience and openness in the locality.
This study also explores the extent to which grassroots NGOs are able to affect the formulation and implementation of policy at the local level, and finds policy influence to be one of the significant outcomes of positive-sum reciprocal engagement. One mechanism through which policy influence occurs is in the context of a mass-line model of communication, in which NGOs participate in discourses on social issues and act as channels for the conveyance of policy information and suggestions. Grassroots NGOs are also able to model innovations and contribute to policy formulation and reform in carrying out concrete programs, which is made possible by an environment characterized by policy flexibility and amenable to experimental points.
Inclusive education and educational diversity: a study of Brunei Government schools
Keywords: Language &amp; Terminology
inclusive education
special education
Brunei

Inclusive education is increasingly being accepted worldwide as the most appropriate means for the education of all children, including those with disabilities. The principle of inclusive education is based on the philosophy that mainstream educational provision should include all children and respond to individual needs. This, however, has profound implications for educators, education planners, and crucially teachers, as they are expected to be able to respond to increasingly diverse classrooms and schools. This research will examine how the Brunei Education system is attempting to respond to pupil diversity in terms of learning needs, by examining the views of policy makers, head teachers and teachers.
This study focuses on the factors which have influenced the development of inclusion in Brunei, the different conceptualisations of needs, the practices which have been adopted and the views of those who are involved in shaping the Brunei education system’s attempt to respond to diverse learning needs in the mainstream education system. Data were generated through interviews, questionnaires, observations and analysis of official policies and documents. The research involved 14 Brunei Government Primary Education schools. The findings of the study indicated that responding to the needs of all children in the mainstream school is a complex challenge. There are several factors which have constrained the development of inclusion in Brunei, some of which are related to how the Brunei education system is structured and the constraints which operate at different levels within the education system. The findings suggest that inclusive education in Brunei is regarded as the integration of children with special educational needs into the mainstream education system and there is little consideration of how to respond to individual needs. There remains a high level of confusion and concern amongst stakeholders in the Ministry in this move to make the Brunei education system more inclusive.
Characterization of endoplasmic reticulum targeting liposomes as drug delivery vesicles
Keywords: liposomes
hepatitis C virus
biochemistry
iminosugars
glycobiology
antivirals

Due to rapid viral and drug resistance mutations, there is a great need for broad-spectrum antiviral therapies that target the host rather than viral processes. This research builds upon previous studies developing α-glucosidase inhibitors known as iminosugars as broad-spectrum antiviral drugs. Initially pH-sensitive liposomes were designed and developed as drug delivery vehicles to enhance cellular internalization for α-glucosidase inhibitors for HIV-1 antiviral treatment. Recent studies by Pollock et al. have shown that polyunsaturated endoplasmic reticulum targeting liposomes known as PERLs, traffic to the ER and are antiviral as a stand-alone therapy against hepatitis B, hepatitis C, and HIV. In addition, α-glucosidase inhibitors formulated and delivered by 'ER-targeting' liposomes have shown potential in recent preclinical studies in vitro and are candidates for future clinical trials as antiviral treatments.
There are two main purposes of this research. Firstly, it aims to develop crucial quantitative analytical methods that detect the α-glucosidase inhibitor drugs when formulated in 'ER-targeting' liposomes. The analytical methods will help elucidate how the chemical properties of small molecules, such as hydrophobicity or polarity, affect the encapsulation efficiency into 'ER-targeting' liposomes, which will help select appropriate formulation processes and dosing regimes for potential future clinical trials. Secondly, this research intends to dissect the possible cellular internalization and trafficking pathways that the 'ER-targeting' liposomes, such as PERLs, utilize to get to the ER in vitro. A large screening assay was conducted to determine what influence each type of phospholipid has on the cellular entry and intracellular movement of 'ER-targeting' liposomes. Several key observations were drawn from this research that will hopefully further the knowledge of 'ER-targeting' liposomes' capability to deliver iminosugars and the pathways involved with the cellular internalization and trafficking of the liposomes in vitro.
Authenticity and the ethics of self-change
Keywords: enhancement
normative ethics
authenticity
moral psychology
neuroethics

This dissertation focuses on the concept of authenticity and its implications for our projects of self-creation, particularly those involving the use of "enhancement technologies" (such as stimulant drugs, "mood brighteners", or brain stimulation). After an introduction to the concept of authenticity and the enhancement debate in the first part of the thesis, part 2 considers the main analyses of authenticity in the contemporary philosophical literature. It begins with those emphasizing self-creation, and shows that, despite their merits, such views cannot adequately deal with certain types of cases, which require a third option, “true self” accounts, emphasizing self-discovery. However, it is argued that in their existing versions, accounts of this third sort are also unsatisfactory.
Part 3 of the thesis proposes a new account of the "true self" sort, intended to improve upon existing ones. Common problematic assumptions about the concept of the true self are critiqued, after which a new analysis of that concept is presented, based on seven different conditions. Two specific definitions of authenticity, respectively emphasizing self-expression and the preservation of one's true self, are provided, and its relation to various associated notions, such as integrity or sincerity, are examined.
Finally, part 4 looks at the implications of the previous parts for the enhancement debate. In particular, it discusses the prospect of technologically enhancing our personality and mood dispositions. Do such interventions always threaten our authenticity, as some worry? A negative answer is provided to that question. Various potential pitfalls hinted at by the inauthenticity worry are discussed and acknowledged. It is, however, argued that such enhancements could still in principle be used in a fully authentic manner, and that they have the potential to bring about genuine improvements in our mood but also to our moral capacities and our affective rationality more generally.
Spectral dimension in graph models of causal quantum gravity
Keywords: random walks
random graphs
lattice quantum gravity
spectral dimension
quantum gravity

The phenomenon of scale dependent spectral dimension has attracted special interest in the quantum gravity community over the last eight years. It was first observed in computer simulations of the causal dynamical triangulation (CDT) approach to quantum gravity and refers to the reduction of the spectral dimension from 4 at classical scales to 2 at short distances. Thereafter several authors confirmed a similar result from different approaches to quantum gravity.
Despite the contribution from different approaches, no analytical model was proposed to explain the numerical results as the continuum limit of CDT. In this thesis we introduce graph ensembles as toy models of CDT and show that both the continuum limit and a scale dependent spectral dimension can be defined rigorously. First we focus on a simple graph ensemble, the random comb. It does not have any dynamics from the gravity point of view, but serves as an instructive toy model to introduce the characteristic scale of the graph, study the continuum limit and define the scale dependent spectral dimension.
Having defined the continuum limit, we study the reduction of the spectral dimension on more realistic toy models, the multigraph ensembles, which serve as a radial approximation of CDT. We focus on the (recurrent) multigraph approximation of the two-dimensional CDT whose ensemble measure is analytically controlled. The latter comes from the critical Galton-Watson process conditioned on non-extinction. Next we turn our attention to transient multigraph ensembles, corresponding to higher-dimensional CDT. Firstly we study their fractal properties and secondly calculate the scale dependent spectral dimension and compare it to computer simulations. We comment further on the relation between Horava-Lifshitz gravity, asymptotic safety, multifractional spacetimes and CDT-like models.
Global comparison of hedge fund regulations
Keywords: offshore
british overseas territories
economic history
cayman islands
hedge funds
onshore
regulatory competition
financial regulation

The regulation of hedge funds has been at the centre of a global policy debate for much of the past decade. Several factors feature in this debate including the magnitude of current global investments in hedge funds and the potential of hedge funds to both generate wealth and destabilise financial markets.
The first part of the thesis describes the nature of hedge funds and locates the work in relation to four elements in existing theory including regulatory competition theory, the concept of differential mobility as identified by Musgrave, Kane’s concept of the regulatory dialectic between regulators and regulatees, and the concept of unique sets of trust and confidence factors that individual jurisdictions convey to the market. It also identifies a series of questions that de-limit the scope of the present work. These include whether there is evidence that regulatory competition occurs in the context of the provision of domicile for hedge funds, what are the factors which account for the current global distribution of hedge fund domicile, what latitude for regulatory competition is available to jurisdictions competing to provide the domicile for hedge funds, how is such latitude shaped by factors intrinsic and extrinsic to the competing jurisdictions, and why do the more powerful onshore jurisdictions competing to provide the domicile for hedge funds not shut down their smaller and weaker competitors?
The second part of the thesis examines the regulatory environment for hedge funds in three so-called offshore jurisdictions, specifically the Cayman Islands, Bermuda and the British Virgin Islands, as well as two onshore jurisdictions, specifically the United Kingdom and the United States.
The final section presents a series of conclusions and their implications for both regulatory competition theory and policy.
Interpretive provisions in  human rights legislation: a comparative analysis
Keywords: statutory interpretation
human rights

This thesis considers interpretive provisions in human rights legislation in the United Kingdom (UK), New Zealand and two Australian jurisdictions: the Australian Capital Territory and the State of Victoria. It deals with the relationship between certain common law interpretive principles which protect human rights and the rules under the interpretive provisions. It also considers what effect the interpretive provisions have on the overall approach to statutory interpretation, particularly in terms of their impact on the roles of intention and purpose. One of the themes of the thesis is that it is possible to identify a common methodology for the application of the various interpretive provisions. This is facilitated by an emphasis on the concept of purpose, which is flexible and capable of being identified and applied at higher levels of abstraction than the concept of intention as commonly applied by the courts. Despite this common methodology, the results of attempts at legislative rights-consistent interpretation in the relevant jurisdictions differ. We shall see that the UK courts have taken a broader interpretive approach than have their New Zealand and Australian counterparts. This will be explained by reference to the respective contexts of the human rights legislation in each jurisdiction, particularly in terms of legislative history. It will be argued that the purpose of the UK legislation to provide remedies in domestic courts for breaches of the European Convention on Human Rights provides the basis for the UK courts’ approach. The absence of this factor is the primary point of distinction between the UK on the one hand, and New Zealand and Australia on the other, though other issues will be explored. Finally, while as a matter of the interpretation of the UK legislation, and especially of the relevant interpretive provision, the approach of the UK courts is defensible, the significant risk to the principle of legal certainty which it poses will be highlighted.
Women's rights and reform in provincial Morocco : from disenfranchisement to lack of empowerment
Keywords: Family Law Reform
Women
Middle East and North Africa
Poverty
Human Development

Morocco is oftentimes praised by academics, development workers, and women’s rights activists as a trailblazer for the empowerment of women in the Middle East and North African region. Its reforms in the realm of family legislation and progress made in human development place the country at the helm of liberalising Arab Muslim-majority societies, even more so after the Arab Spring and Morocco’s peaceful transition to a ‘new’ constitutional order. However, a closer look at women’s rights discourses, legal reforms, its texts and implementation, and the public attitudes towards the enhancement of women’s rights reveals a less empowering situation. The purported goals of the Family Code, as the extolled document showcasing Morocco’s attempt at ameliorating (married) women’s rights, of ‘doing justice to women’ while ‘preserving men’s dignity’ mask the reformed law’s reconsolidation of patriarchal family relations. Many legal grey areas within this particular law, as well as clashing principles emanating from other laws such as the Penal Code, allow judges and the ʿaduls (religious notaries) to exercise discretion and apply the law as they see fit and, to a large extent, as it conforms to their and the community’s vision of the ideal moral order. Moreover, because ‘doing justice to women’ affects men’s and family’s honour, the project of the enhancement of women’s rights has had as a result retraditionalisation of family relations and hierarchical gender structures. Nowhere is this more poignant than in the status of educated single adult girls from provincial areas. They may be poster girls for the development community, but they are pitied by their own communities because they fail to become complete women––married (non-employed) mothers. The story of Morocco’s professed progress is a story of empowering its citizens, but one which does so on paper only. It is also a story which hides the salient details of poorly written reformed laws, obstructed access to justice, continuing widespread misogyny, material poverty and social marginalisation, and cohesive socio-economic programmes, which are rarely followed through.