VictorJuiz/thesis huggingface dataset:
A  multi-centre study of the impact of endometriosis on health-related quality of life and work productivity
Keywords: endometriosis
quality of life
work productivity
diagnostic delay

Background: Endometriosis is a common condition in women of reproductive age, causing pelvic pain and subfertility, but little is known about its impact on health-related quality of life (HRQoL) and work productivity worldwide.
Methods: In 10 countries across five continents, this study recruited 1,418 women, aged 18-45, without a previous surgical diagnosis of endometriosis, scheduled to undergo a laparoscopy to investigate symptoms suggestive of endometriosis or to be sterilised. Pre-operatively, women completed a standardised questionnaire assessing symptoms, diagnostic delay, HRQoL and work productivity using validated instruments. Surgeons completed a standardised questionnaire incorporating findings at laparoscopy including endometriosis stage according to revised American Fertility Society criteria.
Results: There was a mean delay of 9.2 years (SD 8.8), principally in primary care, between the onset of symptoms and diagnostic laparoscopy. This diagnostic delay was longer in centres where healthcare was predominantly state-funded (12.8 vs. 7.6 years; p<0.001). In multivariate analyses, the delay was positively associated with the number of pelvic symptoms (chronic pelvic pain, dysmenorrhoea, dyspareunia and heavy periods; p<0.001) and a higher body mass index (p<0.001). Physical HRQoL was significantly reduced in affected women compared to those with similar symptoms and no endometriosis (p=0.012). Not being in paid employment, severe pelvic pain and moderate-severe disease were associated with reduced physical HRQoL (all p<0.001). Each affected woman lost on average 10.0 hours (SD 10.6) of work weekly, due mainly to reduced effectiveness while working. The annual indirect cost of endometriosis associated with work productivity loss ranged from US399perwomaninIbadan(Nigeria)toUS18,586 per woman in Boston (USA).
Conclusions: Endometriosis significantly impairs HRQoL and work productivity across countries and ethnicities, yet women continue to experience diagnostic delays in primary care. A higher index of suspicion is needed to expedite specialist assessment of symptomatic women. Future research should seek to clarify pain mechanisms in relation to endometriosis severity.
Rare earth metal boryl and gallyl compounds: synthesis and reactivity
Keywords: Main Group
Rare Earth Metals
Inorganic
Organometallic

This Thesis describes the syntheses, characterisation and reactivity of rare earth metal boryl and gallyl compounds. Experimental and computational studies were performed to investigate the structure and bonding in these compounds.
Chapter 1 introduces key metal-boryl and metal-gallyl compounds of the s, p, d and f-blocks via literature review.
Chapter 2 describes the syntheses, structures and bonding analyses of rare earth metal boryl compounds. A short introduction to rare earth metal cations is given.
Chapter 3 describes the syntheses, structures and bonding analyses of rare earth metal gallyl compounds. The preparation of a new class of rare earth metal cations will also be reported. A short introduction to rare earth metal amidinates is given.
Chapter 4 presents reactivity studies of the rare earth metal gallyl compounds described in Chapter 3. To facilitate a direct structure and reactivity comparison, the corresponding boryl compounds were also synthesised. The results of a comprehensive DFT computational study to investigate the structure and bonding in these compounds are also presented. A short introduction to metal-element and metal-metal bond reactivity is given.
Chapter 5 presents full experimental procedures and characterising data for the new compounds reported.
Enhancing motor performance in the healthy and Parkinsonian brain: adaptation, oscillations, and electrical stimulation
Keywords: Subthalamic Nucleus
Motor Learning
Basal Ganglia
Oscillations
Deep Brain Stimulation
Parkinson's
Neurophysiology

Parkinson's disease (PD) is characterized by debilitating impairments in motor control arising from pathophysiological alterations in basal ganglia circuitry and function. In this research thesis two main approaches, namely electrical recording and stimulation, are combined in order to better understand motor performance in Parkinson's disease and ways it might be improved. Three main types of motor behaviors are studied: discrete ballistic movement, repetitive movement, and motor adaptation.
First, deep brain stimulation (DBS) of the subthalamic nucleus (STN) was shown to improve the velocity of discrete, ballistic movements in PD. The neural correlates of ballistic movements were then studied by recording from the STN of PD patients, revealing onset of beta-range desynchronization prior to, and gamma-range frequency synchronization during, performance of fast arm reaches. To determine a causal role for these oscillatory frequencies in motor behavior, the motor cortex of healthy humans was stimulated at either beta or gamma frequency during a 'go/no-go' grip force task. Beta stimulation resulted in slower force generation on 'go' trials but enhanced inhibition during 'no-go' trials, whereas gamma stimulation resulted in faster force generation on 'go' trials.
Second, STN DBS resulted in improved repetitive tapping performance in PD patients through a reduction in variability. Recordings from the STN demonstrated that repetitive movement was accompanied by a substantial and persistent suppression of beta oscillatory activity.
Third, Parkinson's patients were tested on a motor adaptation task, revealing intact learning but impaired retention of a visuomotor rotation. Application of direct current stimulation of the motor cortex resulted in enhanced adaptation during both learning and retention in PD patients and healthy controls.
These results causally implicate the basal ganglia and oscillatory activity in motor control, provide insight into the neuronal mechanisms of motor performance and adaptation, and demonstrate promising new avenues for enhancing motor control in Parkinson's disease.
Predictability of a laboratory analogue for planetary atmospheres
Keywords: ensemble prediction
rotating annulus
47.10.ad
96.12.Jt
imperfect model
47.32.Ef
47.11.Bc
data assimilation
47.55.pb
vacillation
breeding
instability
forecast
Chaos
predictability
92.60.Bh
92.60.Wc
47.52.+j
baroclinic
perfect model
47.20.-k

The thermally-driven rotating annulus is a laboratory experiment used to study the dynamics of planetary atmospheres under controlled and reproducible conditions. The predictability of this experiment is studied by applying the same principles used to predict the atmosphere. A forecasting system for the annulus is built using the analysis correction method for data assimilation and the breeding method for ensemble generation. The results show that a range of flow regimes with varying complexity can be accurately assimilated, predicted, and studied in this experiment. This framework is also intended to demonstrate a proof-of-concept: that the annulus could be used as a testbed for meteorological techniques under laboratory conditions.
First, a regime diagram is created using numerical simulations in order to select points in parameter space to forecast, and a new chaotic flow regime is discovered within it. The two components of the framework are then used as standalone algorithms to measure predictability in the perfect model scenario and to demonstrate data assimilation. With a perfect model, regular flow regimes are found to be predictable until the end of the forecasts, and chaotic regimes are predictable over hundreds of seconds. There is a difference in the way predictability is lost between low-order chaotic regimes and high-order chaos. Analysis correction is shown to be accurate in both regular and chaotic regimes, with residual velocity errors about 3-8 times the observational error. Specific assimilation scenarios studied include information propagation from data-rich to data-poor areas, assimilation of vortex shedding observations, and assimilation over regime and rotation rate transitions.
The full framework is used to predict regular and chaotic flow, verifying the forecasts against laboratory data. The steady wave forecasts perform well, and are predictable until the end of the available data. The amplitude and structural vacillation forecasts lose quality and skill by a combination of wave drift and wavenumber transition. Amplitude vacillation is predictable up to several hundred seconds ahead, and structural vacillation is predictable for a few hundred seconds.
New main group and rare earth complexes and their applications in the ring-opening polymerisation of cyclic esters
Keywords: Cyclic Esters
Ring-Opening Polymerisation
Alkaline Earth
Cationic
Lactide
Caprolactone
amide
alkoxide
Tris(pyrazolyl) hydroborate
Main Group
Rare Earth
Tris(pyrazolyl) methanide
alkyl
Borohydride

This Thesis describes the synthesis and characterisation of new Main Group and Rare Earth alkyl, amide, alkoxide and borohydride complexes and their use as catalysts for the ring-opening polymerisation (ROP) of ε-caprolactone and rac-lactide.
Chapter 1 introduces ROP from an industrial and academic perspective, as well as polymer characterisation techniques. A literature review is given, with an emphasis placed on Main Group catalysts.
Chapter 2 describes the synthesis and characterisation of new homo- and hetero-scorpionate Main Group complexes. An introduction to homo- and hetero-scorpionate ligands is given, as well as a discussion of the ε-caprolactone and rac-lactide ROP activity displayed by the new complexes.
Chapter 3 describes the synthesis and characterisation of new neutral and cationic Main Group borohydride complexes supported by the tris(pyrazolyl)methane and tris(pyrazolyl)hydroborate ligands. A review of borohydride complexes is also given. The ε-caprolactone and rac-lactide ROP activity shown by the complexes presented is also discussed.
Chapter 4 describes the synthesis and characterisation of new mono- and di-cationic yttrium complexes supported by the tris(pyrazolyl)methane and triazacyclononane ligands. An introduction to the synthesis of neutral and cationic Rare Earth complexes is given. An overview of immortal ROP is also provided. The activity of the new complexes towards the immortal ROP of rac-lactide is also discussed.
Chapter 5 contains experimental details and characterising data for the new complexes reported in this thesis.
CD Appendix
contains .cif files for all of the new crystallographically characterised complexes.
The dynamical stereochemistry of photon–initiated bimolecular reactions
Keywords: insertion reaction
bimolecular reaction
polarization
OH
O + H2
stereodynamics

The product state specific stereodynamics of the photon–initiated reaction of O(¹D₂) with H₂ has been investigated by polarised Doppler–resolved laser induced fluorescence, under room temperature bulb conditions. Product state resolved differential cross sections, excitation functions and rotational angular momentum alignments are reported for the following product channels,
O(¹D₂) + H₂(¹Σ+g ; v = 0) -> OH(X²Pi; v' = 0;N' = 14; f) + H(²S).
at a mean collision energy of 12 kJ mol-1. The data are compared with extensive state resolved quasi–classical trajectory (QCT) calculations of the linear and angular momentum distributions and excitation functions conducted on the Schinke–Lester (SL1) and K ab initio ground state (1¹A') potential energy surfaces. Overall, good agreement is obtained between the QCT calculated and experimentally determined stereodynamical features. The results are discussed in light of other recent work on this prototypical insertion reaction, and on the related systems of O(¹D₂) + HD and CH₄.
Niche segregation by cheetah (Acinonyx jubatus) as a mechanism for co-existence with lion (Panthera leo) and spotted hyaena (Crocuta crocuta)
Keywords: African lion
wildlife
spatial segregation
coexistence
carnivore conservation
cheetah
large carnivores
temporal segregation
niche overlap
avoidance behaviour
animal behaviour
intraguild
spotted hyaena
machine learning
felids
Botswana
landscape of risk
Okavango Delta
GPS collars
competition
African carnivores

Intraguild competition and predation have been recognised as important ecological factors influencing the population dynamics of carnivores. The effects of these interactions are often asymmetrical due to a size-related dominancy hierarchy. However, it has been suggested that competitively subordinate carnivores can minimise the costs of predation and competition through spatial and temporal avoidance. Here I investigate the ecological and behavioural mechanisms by which cheetahs (Acinonyx jubatus) coexist with competitively stronger lions (Panthera leo) and spotted hyaenas (Crocuta crocuta). Fieldwork was carried out in the Okavango Delta, northern Botswana, between October 2008 and August 2011. A total of 20 Global Positioning System (GPS) radio-collars were fitted on all known cheetahs (n=6), lion prides (n=5) and spotted hyaena clans (n=6) in the study area (approx. 3 000 km2). Pre-programmed radio-collars recorded locations and activity continuously for each individual and these data were complemented with direct behavioural observations. Cheetah data were analysed with respect to the temporal and spatial likelihood of encountering lions and spotted hyaenas. Results suggest that the response to the risks posed by other predators is species-specific, habitat-specific and dependent on the immediacy of the risk. Resource partitioning was not the main mechanism for coexistence as cheetahs overlapped extensively with lions and spotted hyaenas in time, space and habitat use. Instead, cheetahs adjusted their spatial distribution in response to immediate risks or adapted their habitat use depending on their vulnerability (e.g. behaviours such as feeding or with differing levels of moonlight at night). In general, cheetah temporal and spatial distribution is a hierarchal process, firstly driven by resource acquisition and thereafter fine-tuned by predator avoidance. In addition, habitat heterogeneity seemed to be key in facilitating coexistence. Understanding the behavioural mechanisms that interacting apex predators adopt to regulate these negative interactions could be crucial to carnivore conservation, especially as human-related habitat loss is forcing species into ever smaller areas.
Weird science: affect and epistemology in contemporary literary and artistic projects
Keywords: Oulipo
experimental literature
science
Roubaud
contemporary art

Contemporary cultural practices sometimes appear dispassionate, distant and clinical—committed to conceptualism or formalism. Yet works by Jacques Roubaud and Jacques Jouet (both members of the Oulipo, a group of experimental writers in France that use formal and mathematical constraints to generate new literary forms) suggest a complex relationship between epistemology and affect. This thesis argues that contemporary literary and artistic projects that appropriate the tropes of clinical procedure and experimental constraint, suggest alternative forms of knowledge that implicate the body and emotions of the experiencing subject. In these projects, affect and emotion travel through reason, logic, system and constraint and are transformed in the process. Therefore any analysis of forms of affect in these works must also consider the procedural and scientific aspect, that which makes them "projects". My research, drawing on recent work that places emphasis on affect, considers these projects as test cases often mediating between a series of dichotomies such as reason/emotion and mathematics/poetry. Curiously it is in the encounter with epistemological systems that the value of affect, embodiment and subjectivity is underscored, and this thesis interrogates the various ways that contemporary projects articulate affect almost despite themselves. By passing through a scientific impulse to inquire about and test the validity of epistemological systems, these projects underscore the role of affect in producing knowledge. This thesis insists on the continued importance of the Oulipo in contemporary culture and seeks to provide a larger, interdisciplinary context for oulipian experimentation by analysing similar works in the visual arts. This thesis has four chapters, each based on the materials that the projects themselves investigate: 1) numbers and mathematics, 2) lists, collection, and census-data, 3) itineraries and travel, 4) weather and meteorology. Projects bear witness to what the poet Lyn Hejinian has called the romance of science: its rigor, patience, thoroughness and speculative imagination (Mirage, 1983, 24) In so doing, these projects reveal forms of affect that only emerge through this 'weird science' as literary and artistic experiments.
The role of subthalamic nucleus oscillatory activity as it pertains to decision-making.
Keywords: Impulsivity
Subthalamic Nucleus
Conflict
Deep Brain Stimulation
Theta Oscillations

The subthalamic nucleus (STN), which is the most common target for deep brain stimulation for Parkinson's disease, is known to be crucially involved in motor control. Recent appreciation of the potential non-motor side effects of STN deep brain stimulation, however, has led to speculation that the importance of this nucleus may also relate to processes involved in decision- making, particularly during high conflict scenarios. This thesis concerns itself with investigating the STN's role in action selection during conflict. I begin by recording local field potentials directly from the STN of Parkinson's disease patients while they perform a flanker task that has been shown to elicit theta (4-8 Hz) band activity in areas of the prefrontal cortex involved in cognitive control. I report that like the prefrontal cortex, the STN demonstrates elevated theta activity during conflict. I then test whether STN theta activity is related to that of the prefrontal cortex by recording from both sites simultaneously while patients perform a novel task that temporally separates conflict from stimulus onset or movement. This reveals that theta activity indeed becomes synchronized during conflict, with cortical oscillations driving those of the STN. Thirdly, I investigate how STN oscillations may affect firing rate dynamics by intra-operatively recording local field potentials and single unit activity from patients performing the flanker task. I report that both theta and beta (15-30 Hz) oscillations entrain STN neurons, but only during conflict. Finally, I record cortical and STN activity while a fourth group of patients performs the flanker task. This experiment confirms that cortico-STN theta synchrony is elevated during conflict and may also relate to across-trial adaptations to conflict and errors. Taken together these studies shed light on the mechanisms by which cortical structures may influence the STN during conflict and why STN deep brain stimulation may result in impulsivity.
Investigation into the epigenetic mechanisms involved in microglial activation in the animal model of multiple sclerosis
Keywords: Microglia
Epigenetics

In patients with multiple sclerosis (MS), microglia become activated due to the autoimmune inflammatory response which is directed against the central nervous system (CNS). Following the first disease relapse, microglia remain activated and do not return to a resting state during remissions. Chronically-activated microglia release inflammatory mediators that cause CNS tissue damage, and as such, MS progression has been associated with widespread, chronic microglial activation that correlates with neurodegeneration. To date, only one histone demethylase, Jmjd3, has been described to have a role in inflammation. In agreement with this, up-regulation of Jmjd3 expression was observed following microglial treatment with several pro-inflammatory stimuli, including a range of toll-like receptors ligands and cytokines, suggesting a universal role of Jmjd3 during microglial activation. Subsequent ChIP-qPCR assays revealed that Jmjd3 was recruited to the promoters of Il6, Ccl3, Ccl5 and Nos2 following activation, which, in turn, presented a decrease in their H3K27me3 levels. Using an experimental autoimmune encephalomyelitis (EAE) mouse model of MS, Jmjd3 expression was shown to be increased in activated microglia from mice in the acute and late phases of disease. Immunization with complete Freud’s adjuvant (CFA) alone, also caused microglial activation with Jmjd3 induction, indicating a CFA-mediated TLR2 and TLR4 stimulation of microglia. Further investigation, in which primary microglia were isolated from mice deficient in Jmjd3 (Jmjd3-/-), however demonstrated that the absence of Jmjd3 alone had no resultant effect on the expression of a subset of immune response and inflammation related genes, including the Jmjd3 target genes Il6, Ccl3, Ccl5 and Nos2, before or after activation. This suggested that Jmjd3 acts in concert with a repertoire of other demethylases to facilitate microglia activation, and as such was rendered redundant in this setting. Deciphering the epigenetic profile of microglia in MS and determining whether it is involved in the maintenance of chronic microglial activation in the progressive phase of the disease remains an important line of investigation, and through a clearer understanding of its role in MS pathophysiology, could lead to the development of novel therapeutic interventions in the future.
Stream fusion: practical shortcut fusion for coinductive sequence types
Keywords: program fusion
deforestation
functional programming
program optimisation
program transformation

In functional programming it is common practice to build modular programs by composing functions where the intermediate values are data structures such as lists or arrays. A desirable optimisation for programs written in this style is to fuse the composed functions and thereby eliminate the intermediate data structures and their associated runtime costs.
Stream fusion is one such fusion optimisation that can eliminate intermediate data structures, including lists, arrays and other abstract data types that can be viewed as coinductive sequences. The fusion transformation can be applied fully automatically by a general purpose optimising compiler. The stream fusion technique itself has been presented previously and many practical implementations exist. The primary contributions of this thesis address the issues of correctness and optimisation: whether the transformation is correct and whether the transformation is an optimisation.
Proofs of shortcut fusion laws have typically relied on parametricity by making use of free theorems. Unfortunately, most functional programming languages have semantics for which classical free theorems do not hold unconditionally; additional side conditions are required. In this thesis we take an approach based not on parametricity but on data abstraction. Using this approach we prove the correctness of stream fusion for lists -- encompassing the fusion system as a whole, not merely the central fusion law. We generalise this proof to give a framework for proving the correctness of stream fusion for any abstract data type that can be viewed as a coinductive sequence and give as an instance of the framework, a simple model of arrays. The framework requires that each fusible function satisfies a simple data abstraction property. We give proofs of this property for several standard list functions.
Previous empirical work has demonstrated that stream fusion can be an optimisation in many cases. In this thesis we take a more universal view and consider the issue of optimisation independently of any particular implementation or compiler. We make a semi-formal argument that, subject to certain syntactic conditions on fusible functions, stream fusion on lists is strictly an improvement, as measured by the number of allocations of data constructors. This detailed analysis of how stream fusion works may be of use in writing fusible functions or in developing new implementations of stream fusion.