VictorJuiz/thesis huggingface dataset:
Data fusion models for detection of vital-sign deterioration in acutely ill patients
Keywords: data fusion
Patient monitoring
novelty detection

Vital signs can indicate patient deterioration prior to adverse events such as cardiac arrest, emergency admission to the intensive care unit (ICU), or death. However, many adverse events occur in wards outside the ICU where the level of care and the frequency of patient monitoring are lower than in the ICU. This thesis describes models for detection of deterioration in acutely ill patients in two environments: a step-down unit in which patients recovering from an ICU stay are continuously monitored, and a general ward where patients are intermittently monitored following upper gastrointestinal cancer surgery.
Existing data fusion models for classification of vital signs depend on a threshold which defines a “region of normality”. Bradypnoea (low breathing rate) and bradycardia (low heart rate) are relatively rare, and so these two types of abnormalities tend to be misclassified by existing methods. In this thesis, techniques for selecting a threshold are described, such that the classification of vital-sign data is improved. In particular, the proposed approach reduces the misclassification of bradycardia and bradypnoea events, and indicates the type of abnormality associated with the deterioration in a patient’s vital signs.
Patients recovering from upper gastrointestinal (GI) surgery have a high risk of emergency admission to the ICU. At present in the UK, most intermediate and general wards outside the ICU depend on intermittent, manual monitoring using track-and-trigger systems. Both manual and automated patient monitoring systems are reported to have high false alert rates. The models described in this thesis take into account the low monitoring frequency in the upper GI ward, such that the false alert rate is reduced. In addition to accuracy, early detection of deterioration is a highly desirable feature in patient monitoring systems. The models proposed in this thesis generate alerts for patients earlier than the early warning systems which are currently in use in hospitals in the UK. The improvements to existing models proposed in this thesis could be applied to continuous and intermittently acquired vital-sign data from other clinical environments.
Corrosion protection by paint
Keywords: blister
cathodic disbonding
epoxy
SKP
SAM

This work investigated cathodic disbonding of an unpigmented phenalkamine-cured epoxy coating on mild steel, EC, exposed to 3.5 wt.% NaCl solution. Scanning Acoustic Microscopy (SAM), Scanning Kelvin Probe (SKP), Electrochemical Impedance Spectroscopy (EIS) and optical microscopy have been combined to conduct this study. Several factors affecting the cathodic disbonding process: Film thickness, Cation mobility, Electrolyte concentration, Temperature, Paint composition, Polarisation and Open circuit potential, have been investigated.
SAM results show that the disbonding of EC with a linear scribe spreads outwards from the defect with blisters forming at the anodes (as shown in SKP potential maps) within the disbond. The disbonded region does not correspond to complete adhesion loss as verified by peel-testing.
Semi-immersion tests show that disbonding under full- and semi-immersion conditions have similar behaviours and both follow parabolic kinetics indicating the disbonding is likely to be controlled by a transport process along the coating/metal interface.
An intact epoxy coated mild steel panel coupled with bare mild steel shows that the cathodic reaction beneath the coating obeys Tafel law.
A mathematical model simulating cathodic disbonding which produces realistic potential files and shows the oxygen reduction is mostly located near the disbond mouth has been developed.
Diaries real and fictional in twentieth-century French writing
Keywords: Autobiography
French diaries - history and criticism
Diary novels
Life writing
Diaries
French literature

Whereas the relationship between real autobiography and its fictional forms has been studied at length, the equivalent relationship for diaries has barely been acknowledged, let alone explored. This thesis follows the history of diary-writing – as a field that includes real and fictional diaries and the complex relations between them – in twentieth-century French writing. I take as my starting point the moment in the 1880s when, following a series of successful posthumous diary publications, a new generation of writers became aware that their own journaux intimes would probably come to be published, with considerable consequences for the way their literary œuvre and their very persona as an author (or their textual author-figure) would appear to readers. Of this generation, André Gide exerted by far the greatest influence over the course of diary-writing, and four works in particular experiment, in extremely diverse forms, with the literary possibilities of the diary: Les Cahiers d'André Walter (1891), Paludes (1895), Le Journal des faux-monnayeurs (1926), and his Journal 1889–1939 (1939). After the Second World War, diary-writing continued to draw on forms established by Gide, but now inflected by radical changes in attitudes towards the writing subject: Raymond Queneau's works published under the pseudonym of Sally Mara (1947–62) cast light on attitudes towards the diary at the time of a theoretical exclusion of the writing subject; Roland Barthes experimented with diaries at the point of a return of the writing subject (1977–79); and Annie Ernaux's published diaries between 1993 and 2011 demonstrate the role of diary-writing within the modern field of life-writing. Rather than making a gradual progress towards literary recognition, this history of diary-writing shows that, in a great variety of ways, diaries have consistently been used for their marginal or supplementary role, which simultaneously constructs and qualifies a literary œuvre and author-figure.
Generation NGO: youth and development in urban India
Keywords: development
South Asia
youth
NGO
cities

This dissertation is about the role of NGOs in the lives of subaltern youth in urban India. It is an ethnography on the everyday lives of young people between the ages of 18-32 from impoverished 'red-light areas' in Kolkata who grew up participating in NGO youth programmes. This thesis investigates how NGOs partake in a process of subject making, and how young people interact with and improvise NGO subjectification to better their own lives in a world- class aspiring city.
The youth featuring in this dissertation spent their childhood and adolescence either residing in NGO shelter homes or regularly attending NGO drop-in-centres in their neighborhoods. They came of age attending NGO education programmes, job skills trainings, and human rights workshops. Grounded in 13 months of fieldwork, my ethnography tells the stories of young people’s lives after their participation in NGO programmes, amidst their everyday worlds of work, consumption, and politics.
My examination of the young people’s post-NGO daily lives in Kolkata makes three key contributions. First, it reveals the contradictions of NGO development. It examines the ambivalent effects of NGOs on subaltern young people’s gender and class identity, as well as their social and political subjectivity and mobility. Second, it illustrates the plural forms of agency practised by urban marginalised youth. My thesis demonstrates how young people are not just passive recipients of NGO development opportunities, but active negotiators of development as they interact with NGOs and navigate its attempts to regulate youth. Third, it illustrates how NGOs and post-NGO youth both foster and trouble class divisions in the world-class aspiring city of Kolkata. I illustrate how young people develop cultural dispositions that straddle across subaltern and middle classes and unsettle class boundaries but not inequalities.
This dissertation argues for ethnographic attention to the everyday lives of post-NGO youth as an analytical lens to theorise NGOisation and global city processes in contemporary India and the greater global South.
Determinants of nucleosome organisation and transcription regulation by histone marks
Keywords: epigenetics
gene regulation
nucleosome position

Epigenetics is the study of heritable changes in gene expression that do not involve changes in the underlying DNA sequence. Epigenetic pathways appeared in eukaryotes where multicellular organisms differentiate into different cell types, associated with different phenotypes. The differentiation process is achieved by modifications of the chromatin structure which, by altering the access of trans-factors to the DNA, result in gene activation and repression. Epigenetic mechanisms are therefore viewed as an "extra" layer of information that modulate the genetic information in time and space, necessary for the development and the response to environment stimuli. Although the recent development of high-throughput sequencing technologies has provided an unprecedented insight into epigenetic pathways, the mechanisms controlling the chromatin dynamic as well as their downstream effects on cellular processes are far from being fully understood.
In this thesis, our focus will be restricted to mechanisms acting on the nucleosome level. The first chapter will present the factors known to influence nucleosome positioning as well as the challenges related to the measurement of the nucleosome architecture. The second chapter will introduce a statistical approach, NucleoFinder, capable of identifying nucleosomes consistently positioned in a population of cells. In chapter three, we will make use of NucleoFinder to investigate the importance of cis and trans-factors on the nucleosome architecture in human and show that, despite variation across functional regions, cis-factors have a very modest in influence on nucleosome positioning. Finally, in chapter four, we will aim to identify clusters of histone modifications specific to functionally distinct regions, characterize their function and their association with gene expression level.
Investigating the molecular mechanism of replication restart in fission yeast
Keywords: homologous recombination
DNA replication
RTS1
replication fork barrier

Successful replication of the genome during each cell cycle requires that every replication fork merge with its opposing fork. However, lesions in the template DNA or protein-DNA barriers often impede replication forks and threaten the timely completion of genome duplication. If a fork encounters a replication fork barrier (RFB), it can be subject to a variety of fates. In some cases the replisome is maintained in a manner such that it can resume DNA synthesis when the barrier is removed. Alternatively the stalled fork is simply held in a competent state to merge with the opposing fork when it arrives. However, fork stalling can also precipitate dissociation of the replisome (fork collapse) or even fork breakage. If this happens the recombination machinery can intervene to restore DNA integrity and restart replication, albeit with a risk of causing deleterious genetic change if ectopic homologous sequences are recombined. I have exploited a site-specific RFB in fission yeast termed RTS1 to investigate the consequences of perturbing a single replication fork. RTS1 is a polar RFB (i.e. it blocks fork progression in a unidirectional fashion), enabling replication to be completed by the opposing fork. Despite this, fork blockage at RTS1 triggers a strong recombinational response that is able to restart DNA synthesis, which at least initially is highly error prone. Here, I present my work in establishing a live cell imaging approach to visualizing the recombinational response at the RTS1 RFB, demonstrating that the majority of cells initiate recombination-dependent replication (RDR). RDR begins within a few minutes of fork blockage and is only curtailed by the arrival of the opposing fork. It depends on the Rad52 protein, which remains associated with the restarted fork and whose presence correlates with its infidelity. I also illustrate the significance of various genetic factors, including Rad51, the Rad51 mediators, Fml1 helicase, Rad54 translocase, Pfh1 sweepase, and Cds1 checkpoint kinase, in modulating Rad52 localization and block-induced recombination at the RTS1 RFB.
The influence of emotional stimuli on cognitive processing during transient induced mood states
Keywords: reasoning
mood induction
magnetoencephalography
attention
emotion
memory
depression

Selective attention is a mechanism used to allocate resources to information processing. Both mood states and emotionally salient stimuli can influence which information is selectively attended. This information is subsequently processed in a more elaborative manner and affects task performance. The experiments presented in this thesis explore the influence of mood and emotional stimuli on selective attention and consequently task performance.
Mood induction procedures were used to induce transient neutral, sad, and happy mood states in healthy volunteers. A systematic review and meta-analysis of 41 studies using sad mood induction procedures showed cognitive impairments in performance in the context of task neutral stimuli. In contrast biases in attention towards mood-congruent negative stimuli led to improved task performance.
A series of three behavioural experiments with 197 participants demonstrated that participants made decisions on the basis of less information when that information was preceded by emotional but not neutral stimuli. Induced mood state did not affect performance.
The behavioural and neural correlates of visual attentional processing to emotional stimuli were explored using magnetoencephalography in 24 healthy participants following sad, happy, and neutral mood induction procedures. The M300, a component associated with selective attention, had greater amplitude following presentation of negative compared with positive stimuli, which was associated with improved task performance. Reduced M300 amplitude and impairments in performance occurred following sad mood induction procedures.
The experiments presented in this thesis demonstrate prioritized processing of emotional information and provide some evidence for impaired performance following sad mood induction procedures.
Women and the framed-novelle sequence in eighteenth-century England: clothing instruction with delight
Keywords: tale sequences
women

English women writers of the eighteenth century manifested enthusiasm for a form best described as a framed-novelle sequence, that is, a form in which conversations between characters/narrators are interspersed with embedded narratives. This thesis argues that the framed-novelle, with its distinctive juxtaposition of narrative and critical conversation facilitated feminine intervention in the period’s political, social, and literary debates. It demonstrates that Delarivier Manley, Jane Barker, Eliza Haywood, Sarah Scott, Sarah Fielding and Jane Collier used the framed-novelle sequence to develop a feminine but nonetheless authoritative socio-critical voice which allowed them not only to intervene in contemporary literary debates about the risks and rewards of reading fictions (especially with regards to the wider significance of the feminocentric and apparently trivial matter of amatory, romantic tales)but also to construct timely argument about the effect of fictional exemplarity on readers. Consideration of the literary and cultural contexts of the framed-novelle’s production, specifically its relation to other forms of narrative sequences such as the oriental tale and the fairy tale collection and to the period’s ideals of sociable conversation and critical practice also allows this thesis to identify the framed-novelle’s importance within the larger field of eighteenth-century literary development. Through close readings in each main chapter of an earlier and later framed-novelle by each author, this thesis explores the distinctiveness and internal cohesion of the framed-novelle as a subgenre, while also recognizing the particularity of each writer’s protofeminist perspective on their accumulation of feminocentric tales.
Some problems in the theory &amp; application of graphical models
Keywords: predictors of longitudinal childhood growth
measurement error models
multivariate discrete data models
applied statistics
conditional independence models
graphical models

A graphical model is simply a representation of the results of an analysis of relationships between sets of variables. It can include the study of the dependence of one variable, or a set of variables on another variable or sets of variables, and can be extended to include variables which could be considered as intermediate to the others. This leads to the concept of representing these chains of relationships by means of a graph; where variables are represented by vertices, and relationships between the variables are represented by edges. These edges can be either directed or undirected, depending upon the type of relationship being represented.
The thesis investigates a number of outstanding problems in the area of statistical modelling, with particular emphasis on representing the results in terms of a graph. The thesis will study models for multivariate discrete data and in the case of binary responses, some theoretical results are given on the relationship between two common models. In the more general setting of multivariate discrete responses, a general class of models is studied and an approximation to the maximum likelihood estimates in these models is proposed.
This thesis also addresses the problem of measurement errors. An investigation into the effect that measurement error has on sample size calculations is given with respect to a general measurement error specification in both linear and binary regression models.
Finally, the thesis presents, in terms of a graphical model, a re-analysis of a set of childhood growth data, collected in South Wales during the 1970s. Within this analysis, a new technique is proposed that allows the calculation of derived variables under the assumption that the joint relationships between the variables are constant at each of the time points.
Assessing proportionality in capital cases: a case study of Ohio
Keywords: capital punishment
proportionality review
Ohio
death penalty

When the United States Supreme Court approved the reinstatement of the death penalty in the United States in 1976, it did so based on the promise of new safeguards against comparative excessiveness and relative disproportionality resulting from jury sentencing in capital cases. As Justice Stevens noted in 2008, one of these safeguards – meaningful appellate review of death sentences – is, in practice, non-existent.
This thesis examines the use of this purported safeguard by the Ohio Supreme Court, in the form of comparative proportionality review, to determine the degree to which Ohio capital cases are ‘relatively proportionate’ in the time period after the state adopted life without parole as a sentencing option in 1996. Specifically, this thesis employs two approaches to identifying ‘similar’ cases – the overall aggravation approach (through logistic regression analysis) and the fact specific approach – and then compares each death sentence to its group of ‘similar’ cases to determine whether it is relatively proportionate, given the death sentencing ratio of its comparable group.
After establishing that at least forty per cent of Ohio cases were relatively disproportionate, the thesis argues that Ohio’s current approach violates the requirements of the Eighth Amendment. In particular, the Court’s failure to examine cases sentenced to life as part of its proportionality review and its use of the precedent-seeking approach has the outcome of ignoring death sentences that are comparatively excessive.
Finally, the thesis concludes by offering a normative model by which Ohio can improve its administration of comparative proportionality review. The thesis advocates the use of a ‘purposive’ approach, defining ‘similarity’ on the basis of the intended purpose of punishment, and suggesting that just deserts retribution provides the best approach for determining ‘similarity’.
The role of the CtIP gene as a genetic susceptibility factor for radiation leukaemogenesis
Keywords: radiobiology
leukaemia
cancer

Exposure to ionising radiation increases the risk of cancer, including acute myeloid leukemia (AML), which is the most common myeloid leukaemia. The C-terminal binding protein (CtBP)-interacting protein (CtIP), which is essential for embryonic development and possibly functions as a tumour suppressor, has been identified as a strong candidate for susceptibility to radiation-induced AML (rAML).
Inflation, large-scale structure and inhomogeneous cosmologies
Keywords: cosmology

Determining cosmological parameters from current observational data requires knowledge of the primordial density perturbations generated during inflation. We begin by examining a model of inflation along a flat direction of the minimal supersymmetric Standard Model (MSSM) and the power spectrum of perturbations it can produce. We consider the fine-tuning issues associated with this model and discuss a modification of the potential to include a hybrid transition that reduces the fine-tuning, without affecting the viability of the model. However, supersymmetric flat directions might play a role in other models of inflation as well. In particular, they may cause a feature in the primordial power spectrum of perturbations, unlike the scale-free spectrum assumed in the standard Lambda Cold Dark Matter (LCDM) cosmological model. We then show that in the presence of such a feature, an alternative cosmological model with a large local void and no dark energy provides a good fit to both Type Ia supernovae and the cosmic microwave background (CMB) data from the WMAP satellite. Constraints from the locally measured Hubble parameter, baryon acoustic oscillations and primordial nucleosynthesis are also satisfied. This degeneracy motivates a search for other independent observational tests of LCDM. The integrated Sachs-Wolfe (ISW) imprint of large-scale structure on the CMB is one such test. The ISW imprint of superstructures of size ~100 Mpc/h at redshift z~0.5 has been detected with >4 sigma significance, however it has been noted that the signal is much larger than expected. We revisit the calculation using linear theory predictions in a LCDM cosmology and find the theoretical prediction is inconsistent by >3 sigma with the observation. If the observed signal is indeed due to the ISW effect then huge, extremely underdense voids are far more common in the observed universe than predicted by LCDM.