VictorJuiz/thesis huggingface dataset:
'...and I feel good!' The relationship between body-movement, pleasure and groove in music
Keywords: pleasure
groove
rhythm
body-movement
music psychology

In many musical cultures, people synchronise their bodies to the rhythmic patterns of the music, and such embodied engagements are one of the most overtly enjoyable forms of musical appreciation. However, the ways in which rhythmic structure, body-movement and pleasure are related remains unclear. The present thesis directs a broadly psychological, yet multi-methodological and interdisciplinary, approach towards this relationship, centring on the rhythmic structure of syncopation in groove-based funk music. Through perceptual experiments, computational modelling, rating surveys, neuroimaging and motion-capture recording, syncopation was found to relate, in primarily negatively linear and inverted U-shaped ways, to finger-tapping performance, perceptions of stability, subjective desire to move and feelings of pleasure, neural activity in motor and reward areas, and force, synchrony and periodicity in body-movements. These relationships also depended on individuals’ musical training, dancing experience and groove familiarity. Ecological and embodied theories of perception and a phenomenology of groove provide a backdrop to the empirical findings, on the basis of which it is suggested that the different relationships between syncopation in groove and perceptual, subjective, neural and corporeal attributes interact in reciprocal ways. It is proposed that syncopation invites the body to physically enact the musical structure and directly participate in the rhythms of groove, due to the perceptual tension and ‘open spaces’ afforded by the perception of metric events in syncopation. In groove, body, mind and music extend into each other and this distributed musical process has affective significance. Since the physical pleasures of dancing to music are such a historically and culturally ubiquitous phenomenon, the empirical findings and theoretical proposals of this thesis make significant contributions towards a much-needed coupling of affective and embodied theories of music.
Recruitment and promotion: the role of social ties in publishing
Keywords: recruitment
promotion
job hunting
Great Britain
employee selection
book industries and trade
labour market

This thesis is an in-depth study of the labour market in the UK publishing sector. The aim is to study the role of social ties in publishing in external recruitment and internal promotion. Conventional sociological studies on social ties and labour market outcomes either neglect the perspective of the recruiter and the referrer or fail to explore the mechanisms by which social ties bring about labour market outcomes. This thesis fills these gaps.
I used qualitative research methods, i.e. semi-structured interviews and participant observation for this research. The semi-structured interviews were with 40 interviewees, who were working in different roles (e.g. editorial and design) and levels (e.g. senior and junior) in Oxford and London-based publishing houses. I also served as a committee member of a publishing association in Oxford for seven months. Participant observation serves to triangulate the information I obtained through semi-structured interviews.
This thesis examines different aspects of the labour market process and mechanisms. Regarding recruitment methods, I found that whether recruiters use formal or informal (word of mouth) methods depend on the level of uncertainty of recruiting a wrong person and the cost of making such mistakes. The greater the uncertainty and the cost, the more likely recruiters are to use social ties. Social ties serve to provide information about the availability of suitable employees. With regard to selection processes, I found that professional skills are a must but not enough in themselves. Recruiters use informal method at the final stage of selection to ensure the recruits possess the relevant qualities.
As for job-hunting methods, I found that most newcomers introduce themselves using formal methods to get into publishing but in fact informality is often embedded in formal methods. Interviewees at managerial level almost entirely got their job through informal channels. Social ties have different functions as people rise through the different levels: whereas first entrants use social ties to obtain information about job opportunities, senior level staff members and freelancers carry with them reputation of their fitness to fill a particular position.
Finally, when it comes to internal promotion, employers in my sample promote staff from within the company who already possesses the relevant skills, so as to minimize training costs and get around the uncertainties in settling in new staff. From the employees’ point of view, so long as they perform well in the job and establish a cooperative link with their boss and team members, they would be able to be promoted.
Characterising immune responses to viral vectored vaccines against influenza and hepatitis C
Keywords: influenza virus
hepatitis C virus
viral vectored vaccines

For both influenza viruses and hepatitis C viruses, T cell responses to conserved antigens are one strategy for the human host to control the spread of infection. Such T cell responses can be generated with the use of viral vectored vaccines.
Initially I show that the viral vectored vaccine MVA-NP+M1 can boost memory T cell responses to influenza A virus in adults aged over 50 years old. However within this group, MVA-NP+M1 had reduced immunogenicity in adults who were aged over 70 years old. The influenza virus-specific T cell responses comprised both CD4 and CD8 T cells, and were capable of secreting multiple Th1 cytokines. I then show that MVA-NP+M1 can be safely co-administered alongside seasonal influenza vaccine. The combination does not interfere with the peak T cell response that normally occurs 1 week following MVA-NP+M1. There was a statistically significant increase in antibodies to the H3N2 strain when the vaccines were co-administered, suggesting that the MVA-NP+M1 can act as an adjuvant.
The efficacy of MVA-NP+M1 in humans had been previously evaluated in an influenza virus challenge study. I used a whole blood transcriptome approach to improve the classification of outcomes following influenza virus challenge. For subjects with laboratory-confirmed influenza, individuals with moderate/severe symptoms were found to have a distinct transcriptional signature comprising over 2,000 genes. I used a machine learning algorithm to reduce this variation down to just six genes (CCL2, SEPT4, LAMP3, RTP4, MT1G and OAS3). I validated this finding using expression data from an independently conducted challenge experiment. Data from these six genes was successfully able to predict symptomatic and asymptomatic cases with 89% and 100% accuracy respectively.
To induce T cell responses to hepatitis C virus, I used the vaccines ChAd3-NSmut and MVA-NSmut in a prime-boost regimen. While the combination was highly immunogenic in healthy young adults, MVA-NSmut alone was unable to prime immune responses. The magnitude of T cell responses to the vaccine immunogen was correlated with the breadth of the T cell responses to different epitopes. Re-administration of the same two vaccines after a short time interval (8 weeks) did not improve upon previous peaks in T cell response. However with a longer time interval (> 34 weeks), some individuals were able to achieve higher frequencies of virus-specific T cells compared to the first round of vaccines. A whole blood transcriptome approach was used to study gene expression in volunteers vaccinated with ChAd3-NSmut and MVA-NSmut. Vaccination with MVA-NSmut results in a very strong, but relatively short-lived host gene expression signature. In contrast, the transcriptional response seen following ChAd3-NSmut was much less pronounced. A comparison of the functional analysis of gene lists from both vaccines showed that similar pathways were being activated and repressed.
Velocity selective preparations in Magnetic Resonance Imaging
Keywords: MRI
Magnetic Resonance Imaging
Arterial Spin Labeling

Arterial Spin Labeling (ASL) is a Magnetic Resonance Imaging (MRI) technique that is able to non-invasively quantify the rate of delivery of arterial blood to tissue, known as perfusion. In this thesis a method that uses Velocity Selective (VS) preparations to generate contrast between blood and tissue spins is investigated.
The systematic errors associated with performing a VSASL experiment on imperfect hardware is first investigated. It is shown through simulations and experiments that some VS preparations will underestimate perfusion due to static and transmit magnetic field errors, and that eddy currents caused by switching of magnetic gradients lead to an overestimation of perfusion with VSASL by up to a factor 2. A novel VS preparation, BIR-8, is presented which is shown to be the most robust to these imperfections.
The BIR-8 VSASL technique is then applied in brain tumours where it is found that significant VSASL signal can be detected in less than 5 minutes. However, in a comparison with a spatially selective ASL technique it is found that VSASL overestimates perfusion in these tumours, despite agreeing in Grey Matter.
The systematic errors due to physiology are then modelled, and it is shown that both diffusion and bulk motion will systematically bias the VSASL measurement. A diffusion insensitive VSASL technique, VS-TILT, is then developed and it is found that a significant proportion of the VSASL signal originates from diffusion effects. Theoretical models for the shape of the bolus in vascular networks are also derived, and it is shown that an isotropic network of laminar vessels produces the most efficient saturation, but saturation is also achieved with plug flow.
The diffusion insensitive VS preparation is then applied in an attempt to isolate the venous compartment in order to measure Oxygen Extraction Fraction. A kinetic model is derived in order to optimise the acquisition. However, it is found that accurate measurements of OEF would not be produced by this sequence in a clinically realistic time.
Authenticity and the commodity: physical music media and the independent music marketplace
Keywords: Texas
culture industries
ethnography
sound recording
material culture
music industry
sound technology
Austin
consumption
ethnomusicology
anthropology
collecting
popular music
materiality

This thesis examines the circulation of physical music media (78rpm records, LPs, CDs, tape) in the independent music marketplace. It is based on six months of ethnographic fieldwork in Austin, Texas, amongst the producers of goods for the independent marketplace, independent music stores and consumers of these goods and services. Against prevailing constructivist interpretations, I will argue for the value of authenticity as an analytical anthropological concept because it unites what my research participants value about materiality, technology, and marketplace relationships. In the independent marketplace for physical music media, authenticity is a multi-local, multi-vocal phenomenon. A nexus of economic rationales, design, reproduction-technologies, histories and personal conduct interact in an ongoing process that authenticates music commodities and their marketplace. This means that particular commodities are sought out over others on account of the multi-local authenticities they anchor. The thesis firstly demonstrates how the independent music scene safeguards claims to authentic identities by constructing an opposition to the mainstream, drawing on discourses of ethical production and consumption, sound technologies, spaces of consumption and cultural production. Secondly, I will uncover how physical music media and sound-reproduction technologies are assessed as effective providers of authentic musical reproductions according to their historical contingencies and performative material capacities. Thirdly, I develop the notion of the scene (Shank 1994) from its previously genre-fixed perspective to encompass multiple musical styles operating within a common social network of producers, retailers and collectors. The pluralistic scene I describe utilises multiple musical genres and nuanced notions of materiality and authenticity to establish their complex hierarchy of sonic and technological experiences.
Contest and community: wonder-working in Christian popular literature from the second to the fifth centuries CE
Keywords: apocrypha
Judaism in the Roman world
Acts of Peter
early Christianity
Acts of Silvester
Magic
ritual

In this thesis, I hope to demonstrate that what I call the magic contest tradition, that is the episodes of competitive wonder-working that appear in a wide variety of apocryphal and non-canonical Christian texts, made an important contribution to the development of Christian thought during the second to the fifth centuries CE. This contribution was to articulate ‘the way’ to be a Christian in a world which was not isolated from the secular, and not insulated from the reality of the Roman empire. First, I demonstrate that a tradition of texts which feature magic contests exists within the broader scope of non-canonical Christian literature (looking at this literature across communities, regions and time periods). Second, I identify what the major features of the traditions are, e.g. what form the narratives take, what the form for a magic contest is, and what the principles used to build the magic contests are, and how these principles feature in the texts. The principles I identify are power, authority, ritual, and conversion, as well as their use as historical exempla. Third, I discuss what the texts did in the context of the time period, and for the communities that produced and read them: in other words, how did the this tradition work? I show that they served multiple purposes: as tests of faith, religious truth and ways to proclaim such; as constructors and markers of group identity (and the perilous task of identifying the insiders and those who should be outsiders); as calls to unity within the overarching diversity of the times and places, and a unified front for the ‘battle’ against evil. I suggest that the texts present a model for how one could decide what the ‘true faith’ was and how one could practice it in the turbulent environment that early Christians faced both before and after Constantine.
Micro-mechanics of irradiated Fe-Cr alloys for fusion reactors
Keywords: neutron
dislocations
size effects
radiation
micro-mechanical testing
dose rate
radiation defects
radiation damage
displacement damage
plasticity
irradiation
ion implantation
fe-cr alloys

In the absence of a fusion neutron source, research on the structural integrity of materials in the fusion environment relies on current fission data and simulation methods. Through investigation of the Fe-Cr system, this detailed study explores the challenges and limitations in the use of currently available radiation sources for fusion materials research.
An investigation of ion-irradiated Fe12%Cr using nanoindentation with a cube corner, Berkovich and spherical tip, and micro-cantilever testing with two different geometries, highlighted that the measurement of irradiation hardening was largely dependent on the type of test used. Selected methods were used for the comparison of Fe6%Cr irradiated by ions and neutrons to a dose of 1.7dpa at a temperature of 288°C. Micro-cantilever tests of the Fe6%Cr alloy with beam depths of 400 to 7000nm, identified that size effects may significantly obscure irradiation hardening and that these effects are dependent on radiation conditions. Irradiation hardening in the neutron-irradiated alloy was approximately double that of the ion-irradiated alloy and exhibited increased work hardening. Similar differences in hardening were observed in an Fe5%Cr alloy after ion-irradiation to a dose of 0.6dpa at 400°C and doses rates of 6 x 10-4dpa/s and 3 x 10-5dpa/s. Identified by APT, it was shown that increased irradiation hardening was likely to be caused by the enhanced segregation of Cr observed in the alloy irradiated with the lower dose rate.
These observations have significant implications for future fusion materials research in terms of the simulation of fusion relevant radiation conditions and micro-mechanical testing.
The accountability of UN post-conflict administrations for violations of international humanitarian law and human rights law
Keywords: international territorial administrations
immunities of the UN
occupation of territories
legal responsibility
human rights
armed conflict
accountability

The thesis explores the extent to which the UN post-conflict administrations are accountable towards the populations of the territories they administer. The post-conflict administrations temporarily assume legislative and administrative powers to support the peace processes, to help to resolve the sovereignty issues or to establish administrative structures that might be non-existent in these territories. The thesis argues that, while the exercise of these extensive powers entails the accountability of the UN, in practice this accountability is not effectively engaged.
As opposed to other forms of accountability, the focus is on the international legal responsibility of the UN as the prominent and most meaningful form of accountability, in the accountability relationship between the administrator and the administered, which gives the populations of the administered territories the opportunity to challenge the acts of international administrations and seek redress.
In exploring the legal responsibility of the UN and in line with Article 4 of the ILC Draft Articles on the Responsibility of International Organizations, which states only an act of an international organization that constitutes a breach of an international obligation entails its responsibility, this thesis initially explores the extent of international obligations arising from, and the extent of applicability of, three bodies of law. First, the thesis discusses the applicability of international humanitarian law, the fundamental principles of which have traditionally been part of UN peace operations practice. Next, it considers the applicability of the law of occupation, which shares stark factual similarities with the UN post-conflict administrations. Finally, the applicability of international human rights law, which is consistently part of the applicable law in post-conflict territories, and the protection and promotion of which is consistently included in the mandates of post-conflict administrations is examined. The thesis argues that the simultaneous application these bodies of law would help to create a legal framework to engage the accountability of UN post-conflict administrations and this legal framework should be complemented by effective accountability mechanisms.
Efficient numerical methods for the solution of coupled multiphysics problems
Keywords: error estimation
partial differential equations
preconditioning
multiphysics problems
numerical methods

Multiphysics systems with interface coupling are used to model a variety of physical phenomena, such as arterial blood flow, air flow around aeroplane wings, or interactions between surface and ground water flows. Numerical methods enable the practical application of these models through computer simulations. Specifically a high level of detail and accuracy is achieved in finite element methods by discretisations which use extremely large numbers of degrees of freedom, rendering the solution process challenging from the computational perspective. In this thesis we address this challenge by developing a twofold strategy for improving the efficiency of standard finite element coupled solvers. First, we propose to solve a monolithic coupled problem using block-preconditioned GMRES with a new Schur complement approximation. This results in a modular and robust method which significantly reduces the computational cost of solving the system. In particular, numerical tests show mesh-independent convergence of the solver for all the considered problems, suggesting that the method is well-suited to solving large-scale coupled systems. Second, we derive an adjoint-based formula for goal-oriented a posteriori error estimation, which leads to a time-space mesh refinement strategy. The strategy produces a mesh tailored to a given problem and quantity of interest. The monolithic formulation of the coupled problem allows us to obtain expressions for the error in the Lagrange multiplier, which often represents a physically relevant quantity, such as the normal stress on the interface between the problem components. This adaptive refinement technique provides an effective tool for controlling the error in the quantity of interest and/or the size of the discrete system, which may be limited by the available computational resources. The solver and the mesh refinement strategy are both successfully employed to solve a coupled Stokes-Darcy-Stokes problem modelling flow through a cartridge filter.
Modulation of the hypoxic response in cancer; inhibition of the HIF-1α/p300 protein-protein interaction
Keywords: Hypoxia
Cancer Research
Peptidomimetics

Hypoxia inducible factor (HIF)-1α is a heterodimerically-activated transcription factor central to the cellular response to hypoxic environments and is often upregulated in cancer. Binding of HIF-1α to the co-activator p300 is necessary for the hypoxia-induced transcription of many oncogenic proteins. The aim of this project was to develop novel small molecule inhibitors of the HIF-1α/p300 protein-protein interaction (PPI).
Initial work focused on designing, validating and optimising two high-throughput competition binding assays to screen for inhibitors of the PPI (Chapter 2). Alongside these, zinc ejector assays for both p300 and KDM4A proteins were developed to probe the mechanism of action and selectivity. Analysis of hits from a natural product high-throughput screen (HTS) revealed two compound classes; benzoquinones and 2-substituted indandiones, which modulate the PPI. The potency of these series correlated with the reactivity of the core functional groups, which act as electrophiles to covalently modify reactive cysteines, ejecting structural zinc and disrupting the p300/KDM4A protein fold (Chapter 3). Conjugating electrophilic groups to putative HIF-1α/p300 inhibitors did not replicate the activity of the zinc ejecting HTS hits (Chapter 4).
Further work focused on non-covalent inhibitors of the HIF-1α/p300 interaction, first with peptide truncates, and then rationally designed α-helix peptidomimetics. An 11mer truncate showed encouraging activity (IC50 ≈ 70 μM), and corresponded to a key α-helix in the HIF-1α C-terminal transactivation domain. Three distinct double-sided scaffolds were used to imitate up to five hot-spot ampiphilic residues on this α-helix (Chapter 6 and 7). Of the 35 compounds screened, only modest inhibition was observed (IC50 ≈ 200-500 μM).
Future work will look to conjugate electrophilic functionality onto the 11mer peptide in an attempt to gain potency from zinc ejection, while maintaining selectivity for p300.