VictorJuiz/thesis huggingface dataset:
The genesis of Clough's poetry
Keywords: Clough

This thesis examines the early poetry of Clough, written between 1830 and 1841, in the light of the information about his personal and intellectual life provided by published and unpublished manuscripts, essays, letters and diaries. More specifically, it sets out to determine the degree to which the seeds (thematic and formal) of Clough’s more mature work can be discerned in the earlier.
Chapter One discusses the influence of Clough’s childhood reading, and particularly the heroic ideal as encouraged by his mother. It traces the way this developed, particularly under the historical ideas of Thomas Arnold and the Liberal Anglicans, and the fatalistic moral problems this created. Chapter Three considers Clough’s responses to the Oxford Movement. It teases out those elements that attracted Clough and those he came to reject, particularly in the light of Tractarian ideas about reserve, in relation to poetry, truth and personal behaviour.
Chapters Two and Four provide chronological, text-by-text accounts of the Rugby and Balliol poems respectively, offering judgments about influences, dates and sources, and interpretations in the light of Chapters One and Three respectively. Chapter Two argues that much of the Rugby poetry reflects an escapist lament for the past and a failure of will to restore it. Chapter Three argues that Clough’s engagement with Tractarian ideas about reserved truth provides the key context for many of these poems.
Chapter Five traces the way in which Clough’s early poetics, derived from Wordsworth via Thomas Arnold, were gradually replaced by his more mature, ambiguous approach which also emerged from his encounters with Tractarian reserve.
Two appendices collect ten poems and poetic fragments omitted from Mulhauser’s standard edition; three additional variant texts for poems included by Mulhauser; and four previously unpublished letters to Clough from his friend WilliamTylden.
An age of emotion: expertise and subjectivity in old age in Britain, 1937-1970
Keywords: history of emotions
old people
twentieth-century British history
elderly
ageing
old age

This thesis heeds W. Andrew Achenbaum’s call for historians of ageing to analyse the inner lives of their subjects. Building on and problematizing existing studies of health and welfare policies for the old, it explores the ways that mid-century public and private life shaped how individuals felt about old age. Both public discussions and private narratives of ageing are used to consider how older people understood and expressed their emotional experiences during a challenging period of the life cycle.
I argue that old age in general, and its emotional dimensions in particular, are missing from British historiography. Yet both were vital to social life in the mid-century, when the ageing population was an important political issue and a large number of experts hoped to manage the emotional and psychological aspects of this ‘problem’. This thesis begins by setting out this national context for old age, showing that heightened interest in ageing and emotion were significant influences over the expansion of the welfare state. However, contrary to the expectations of mid-century researchers and policy-makers, my subsequent chapters show that older people frequently maintained their social roles and relationships through informal means. This thesis explores how ageing men and women engaged with work, retirement, ill health, marriage, bereavement, fashion, beauty culture, and autobiography as opportunities to find meaning in late life.
Together, these varied perspectives on old age make a series of interventions in its history. I argue that historians could do much more to detail the significance of the life cycle for their subjects, whether they write political, social, or cultural history. As this thesis shows, such studies should approach ageing as a lifelong and personal process, which has been shaped by reminiscence and story-telling. I suggest that historians of emotion are best-equipped to write scholarship that is sensitive to the passing of time and personal biography in this way.
Anglo-Scandinavian literature and the post-conquest period
Keywords: medieval romance
oral literature
Anglo-Scandinavian
Middle English

This thesis concerns narratives about Anglo-Scandinavian contact and literary traditions of Scandinavian origin which circulated in England in the post-conquest period.  The argument of the thesis is that in the eleventh century, particularly during the reign of Cnut and his sons, literature was produced for a mixed Anglo-Danish audience which drew on shared cultural traditions, and that some elements of this largely oral literature can be traced in later English sources.  It is further argued that in certain parts of England, especially the East Midlands, an interest in Anglo-Scandinavian history continued for several centuries after the Viking Age and was manifested in the circulation of literary narratives dealing with Anglo-Scandinavian interaction, invasion and settlement.  The first chapter discusses some narratives about the reign of Cnut in later sources, including the Encomium Emmae Reginae, hagiographical texts by Goscelin and Osbern of Canterbury, and the Liber Eliensis; it is argued that they share certain thematic concerns with the literature known to have been produced at Cnut’s court.  The second chapter explores the literary reputation of the Danish Earl of Northumbria, Siward, and his son Waltheof in twelfth-century sources from the East Midlands and in thirteenth-century Norwegian and Icelandic histories.  The third chapter deals with an episode in the Middle English romance Guy of Warwick in which the hero helps to defeat a Danish invasion of England, and examines the romance’s references to a historical Danish right to rule in England.  The final chapter discusses the Middle English romance Havelok the Dane, and argues that the poet of Havelok, aware of the role of Danish settlement in the history of Lincolnshire, makes self-conscious use of stereotypes and literary tropes associated with Danes in order to offer an imaginative reconstruction of the history of Danish settlement in the area.
The regulation and inhibition of P-TEFb
Keywords: cyclin dependent kinase
transcription
phosphorylation

Correct regulation of transcription is essential for maintaining a healthy cellular state. During transcription RNA polymerase II (Pol II) proceeds in a regulated manner through several transitions to ensure appropriate control of synthesis and enable correct processing of the pre-RNA. Shortly after initiation Pol II is caused to pause by the binding of factors, DSIF and NELF. To enable transition of Pol II into the elongation phase CDK9/cyclin T phosphorylates the C-terminal domain (CTD) of Pol II, DSIF and NELF. This phosphorylation releases the paused state and provides an alternative set of post-transcriptional modifications on the CTD to generate a binding platform for elongation, histone modifying and termination factors. CDK9/cyclin T is itself regulated within multicomponent complexes. A small activated complex, containing Brd4, recruits CDK9/cyclin T to active sites of transcription, thereby promoting the elongation of transcription. The role of CDK9/cyclin T in the regulation of transcription has resulted in its validation as a drug target against several disease states including cancer, HIV and cardiac hypertrophy.
In this thesis, I present the crystallographic structures of a series of 2-amino-4-heteroaryl-pyrimidine compounds and the roscovitine derivative, (S)-CR8, bound to CDK9/cyclin T and CDK2/cyclin A. In combination with thermal denaturation data and kinetic analysis, these structures have suggested chemical modifications that might be made to increase the CDK9 specificity of these compounds. I have also validated the use of a mutated form of cyclin T for use in the development of CDK9/cyclin T inhibitors.
In addition, I present both structural and kinetic analysis of the Brd4-CDK9/cyclin T interaction. I show that C-terminal fragments of Brd4 enhance the in vitro kinase activity of CDK9/cyclin T against the Pol II CTD. Furthermore, I demonstrate that this enhancement may be inhibited by Plk1-mediated phosphorylation of Brd4. Finally, I show that Brd4 binds to a site that spans CDK9 and cyclin T and I propose detailed molecular models of the Brd4-cyclin T interaction.
Iron deficiency and susceptibility to infection: a prospective study of the effects of iron deficiency and iron prophylaxis in infants in Papua New Guinea
Keywords: infectious disease
Iron nutrition
malaria
disease prevention
respiratory infections

Investigation of the relationship between iron deficiency, iron supplementation and susceptibility to infection, was suggested by the author's initial observations of an association of anaemia with serious bacterial infections in infancy in Papua New Guinea. The bulk of previous longitudinal clinical intervention studies in infancy showed beneficial effects of iron supplementation. However, defects of control and design and recording in these studies and contradictory anecdotal reports left the question unresolved.
A prospective, placebo-controlled, randomised, double-blind trial of iron prophylaxis (3ml intramuscular iron dextran = 150mg Fe) to two month old infants was carried out on the North Coast of Papua New Guinea where there is high transmission of malaria.
A literature review, pilot studies, protocol, demography, geography and laboratory methods developed are described.
Findings indicate that the placebo control group became relatively iron deficient over the first year of life and that the iron dextran group had adequate, although not excessive iron stores and a higher mean haemoglobin; however, the prevalence and effects of malaria recorded in the field were higher in the iron dextran group. Analysis of field and hospital infectious morbidity in the trial indicated a deleterious association with iron dextran for all causes including respiratory infections (the main single reason for admission). Total duration of hospitalisation was significantly increased in the iron dextran group. Analysis of other factors showed (1) a higher admission rate associated with low weight-for-height recorded at the start of the trial; (2) a significant positive correlation between birth haemoglobin and hospital morbidity rates; (3) increased malaria rates in primiparous mothers of the cohort infants who received iron infusion during pregnancy; (4) lower relative risk of malaria associated with iron prophylaxis in individuals with alpha thalassaemia, which was found to be highly prevalent in this region.
In conclusion, it is suggested that policies of iron supplementation, total dose iron injection and routine presumptive iron therapy for anaemia which are widely in practice in malaria endemic areas should be closely reviewed.
Pulse shaping for broadband photoassociation of cold molecules
Keywords: cold molecules
pulse shaping
ultrafast
pulsed lasers

The development of the field of the science of ultra-cold matter has opened some exciting possibilities in exploring the quantum-mechanical processes which dominate matter interactions at the sub-microscopic scale. Although methods of cooling atoms are well established, molecular cooling is made difficult by molecules’ additional vibrational and rotational degrees of freedom. It was the goal of the research in this work to approach molecular cooling indirectly, by using broadband shaped-pulse photoassociation for the generation of tightly bound ultracold Rb2 molecules.
The experiments towards this goal conducted by our group included a pumpdecay experiment to observe the generation of ground state singlet or triplet molecules. However, attempts to observe an increase in ground state population have been unsuccessful. A pump-probe study of wavepacket dynamics in the 5s+5p electronic state was conducted in order to determine the appropriate timing for the application of an additional pulse to dump population into the ground state. Although the attempt to observe wavepacket oscillations has been unsuccessful, pump-probe studies have yielded the observation of loosely bound excited state molecules as a result of the photoassociation pulse. These results are promising as a first stage in a fully coherent pump-dump approach to stabilisation into the lowest vibrational ground state.
This thesis will provide an introduction and overview to the concerns involved in addressing the problem of molecular cooling and generation. Experimental techniques will be discussed including pulsed laser systems, optical parametric amplifi- cation, and the presentation of an original design for pulse shaping with an acoustooptic modulator. The emphasis of these discussions will be on the principles and operating procedures required for the use of these devices as home-built systems. The thesis will conclude with the results of pump-probe experiments utilising the pulse shaper as a spectral cutting device.
The role of tryptophan and the mTOR pathway in T cell fate determination
Keywords: immune escape
tumour immunology
T cell biology

The adaptive immune response forms an essential part of the cancer immuno-editing process, whereby nascent malignant cells are detected and destroyed prior to forming tumours. The process is tightly controlled to minimise collateral damage to healthy tissue. One of the mechanisms evolved for this purpose and frequently co-opted by malignant cells is the creation of a microenvironment scarce in essential amino-acids through the use of catabolic enzymes such as Indoleamine 2,3-dioxygenase (IDO) , responsible for the rate-limiting step in tryptophan catabolism. The evolutionary conserved GCN2 and mTORC1 pathways respond to amino-acid starvation by triggering emergency homeostatic response programmes that aim to conserve nutrients by shutting down biosynthetic pathways, slowing cell cycle progression and facilitating autophagy. This research project focuses on elucidating the interaction between IDO activity and these pathways and its implications for the immune-editing process.
The role of the mTOR kinase as a regulator of T cell fate following exposure to cognate antigen has recently become apparent. Experiments described herein confirm that in murine and human models of T cell activation exposure to tryptophan starvation results in significant mTORC1 inhibition and a modified phenotype with reduced Tbet expression, altered cytokine secretion profile, greatly impaired proliferative capability and expanded CD4+ FoxP3+ CD25high subpopulations. Additional results confirmed that the action of IDO is sufficient to deplete tryptophan from the microenvironment to levels sufficient to depress the mTORC1 axis and trigger GCN2 activity even in tumour cell lines. Lower extracellular tryptophan levels were necessary to perturb these pathways In IDO expressing cell lines, suggesting that compensatory mechanisms allow continued proliferation of malignant cells in the face of conditions that severely impede an anti-cancer immune response. In conclusion, manipulation of the mTORC1 axis via IDO-induced tryptophan depletion is an important tumour immune-escape mechanism that can be a target for cancer immunotherapies.
Mechanically interlocked and redox switchable molecules at surfaces
Keywords: rotaxane
optically-active functional groups
redox-active
catenane
mechanically interlocked molecules
self assembled monolayer

This thesis explores the surface assembly of mechanically interlocked molecular architectures at gold surfaces for potential applications in molecular switches, anion sensing and stimuli (redox and optical) responsive molecular films.
Chapter One introduces the field of mechanically interlocked molecules focusing on rotaxane and catenane surface assemblies in the form of single molecule thick self-assembled monolayers. A review of the surface-attached characteristics of mechanically interlocked molecules is given before exploring specific anion template directed strategies for their construction. The potential to incorporate both redox-active and optically-active functional groups within these mechanically interlocked molecules is also discussed.
Chapter Two provides the experimental details and procedures employed in this thesis to characterise the molecular systems under investigation.
Chapter Three introduces several surface characterisation techniques such as; ellipsometry, contact angle, X-ray reflectivity and X-ray photoelectron spectroscopy, with a particular focus of applying these tools to probe the surface co-conformation of switchable and interlocked molecules at surfaces. Electroanalytical techniques such as cyclic voltammetry, chronoamperometry and electrical impedance spectroscopy are also introduced.
Chapter Four details the surface assembly of a series of ferrocene containing anion templated catenane self-assembled monolayers on gold. Detailed electrochemical and angle resolved X- ray photoelectron spectroscopy characterisation elucidates the co-conformation upon surface attachment.
Chapter Five details the anion templated surface assembly of a redox-active rotaxane self- assembled monolayer on gold. Subsequent electroanalysis and X-ray photoelectron spectroscopy characterisation confirms the structural integrity of the film and a possible co- conformation at the surface is discussed.
Chapter Six describes efforts towards constructing optically responsive hybrid d-f lanthanide containing mechanically interlocked molecules. Initial work focuses on switching characteristics of a redox switchable antennae and its ability to modulate the luminescence of a series of lanthanide complexes in solution. Subsequent surface attachment of the lanthanide complexes in the form of emissive self-assembled monolayers is also investigated.
Structural characterization of liver fibrosis in magnetic resonance images
Keywords: local phase
texture
MRI
liver disease

The overall clinical motivation of this thesis is to differentiate between the different stages of liver disease stratifying into: no disease, mild disease, and severe fibrosis using Magnetic Resonance Imaging (MRI). As a related aim, we seek to differentiate as much as possible pericellular and nonpericellular fibrosis. This latter is clinically important, but currently no method exists that is able to perform this. Quickly, we realised that these aims push low level image analysis beyond their current bounds and so a great deal of the thesis is dedicated to extending such techniques before they can be applied.
To work on the most fundamental low level image analysis concepts and algorithms we choose one of the most recent developments, namely continuous intrinsic dimensionality (ciD), which allows the continuous classification of homogeneous patches from 1D structures to intrinsically 2D structures. We show that the current formalism has several fundamental limitations and we propose a number of developments to improve on these.
We re-evaluated feature energy statistics that were originally proposed in ciD, and additionally we examined the confidence one may have in stateof- the-art methods to estimate the orientation of features. We show that new statistical methods are required for feature energy, and that orientation predictability is more important than correctness of the estimation. This evaluation led us to the monogenic signal local orientation.
Analysis of feature or texture energy is also a main contribution of this thesis. Within this framework we propose the Riesz-weighted phase congruency model. This is able to detect internal texture structures but it is not capable of delineating boundaries. Nevertheless, it proves an appropriate basis for texture quantification.
Finally, we show that in contrast to using the standard established Kovesi approach, the developed texture measure leads to good results on the suboptimal T1w MRI liver image staging images. We show that we are able to differentiate automatically between the separate disease scores and between pericellular and non-pericellular fibrosis.
Developing paediatric quality indicators for UK general practice
Keywords: general practice
paediatrics
quality indicator
primary health care
consensus study

The overall aim of this thesis is to define a candidate set of quality indicators that are evidence-based, feasible to implement, and have the potential to improve the quality of care provided for children in UK general practice.
The indicators were developed using a three-stage process. First, the areas and aspects of care of highest priority for quality indicator development were identified. This was achieved by seeking the views of primary care clinicians and by undertaking a formal analysis of unplanned hospital admissions for ambulatory care sensitive conditions. Then, the evidence-base to underpin indicator development was identified through an overview of Cochrane systematic reviews of interventions relevant to the primary care of children. A search of SIGN and NICE national guidelines was also conducted to inform the evidence-base. Lastly, an expert panel determined the formulation and selection of indicators by applying the RAND appropriateness methodology.
This process created a final set of 26 quality indicators in six priority areas: early recognition of potentially serious illness (n=7); child protection and safeguarding (n=4); mental health (n=4); health promotion (n=1); routinely managed conditions (n=6); and general practice management (n=4). The main strength of these indicators is that they reflect a strong professional consensus on their validity and feasibility. The main weakness is that the indicators are underpinned by evidence mainly derived from expert opinion rather than formal research; the requirement for professional consensus means that they do not challenge existing models of care delivery.
Measurement of the inclusive W+/- cross section at (sq.root)s = 7 TeV with the ATLAS detector
Keywords: ATLAS
LHC
W boson

A measurement of the W+ and W− cross section in the electron channel is presented. The measurement is performed using data collected with the ATLAS experiment in 2011, amounting to an integrated luminosity of 4.58 fb−1. The centre of mass energy is √—s = 7 TeV. The measurement is performed differentially in the electron pseudorapidity. The W charge asymmetry is also presented. The results are compared to theoretical predictions calculated at next-to-next-to-leading order in perturbative QCD using various Parton Distribution Functions.