VictorJuiz/thesis huggingface dataset:
Reactions to the Extra-organizational Deviance of Coworkers: Implications for Individuals in the Workplace
Keywords: deviance
workplace
trust

Drawing on the labelling process in reactions to deviance, a model of the interplay of a coworker’s extra-organizational deviance and an individual’s reactions to that coworker has been developed. Three studies were conducted to further explore the model in order to more fully understand the phenomenon of extra-organizational deviance. The first study (n=12) was exploratory in nature. It established the relevance of extra-organizational deviance in individuals’ work lives and highlighted the detrimental effect that behaviours outside of work could have at work. It also highlighted the potential for beneficial outcomes in situations of positive extra-organizational deviance. The second study (n=120) was a vignette study that demonstrated significant differences when looking at positive and negative extra-organizational deviance for both attitudinal and behavioural reactions. In this study, when individuals learned of their coworker’s negative extra-organizational deviance, perceptions of trust, trustworthiness, and liking all decreased, as did helping. There were no corresponding significant results when individuals learned of their coworker’s positive extra-organizational deviance. The second study also demonstrated the moderating effects of high initial levels of liking and competence under different circumstances. The third study (n=21) provided a more detailed look at the variables in the second study by concentrating on actual situations of extra-organizational deviance that participants had experienced. This study highlighted the complexities in reactions to extra-organizational deviance, particularly as it relates to competence and liking.
The Decay Constant of 87Rb and A Combined U-Pb, Rb-Sr Chronology of Ordinary Chondrites
Keywords: Rubidium
Strontium
Decay constant
Ordinary Chondrites
U-Pb
Rb-Sr
Geochronology
Cosmochronology

The 87Rb-86Sr system is a widely used long-lived isotope geochronometer. 87Rb, the naturally occurring radioactive isotope of Rb, undergoes beta-decay to stable 87Sr with a half-life of approximately 50 Ga. Decay of 87Rb to 87Sr results in variable 87Sr/86Sr in minerals with different Rb/Sr, and measurement of 87Rb/86Sr and 87Sr/86Sr allows for the determination of the age of the rock. Accurate ages depend both on the quality of the isotopic analysis and on the accuracy of the 87Rb decay constant, lambda87. Although the currently accepted value for lambda87 of 1.42 × 10-11a-1 has been in use for over 30 years, there is growing evidence that it is not accurate. Recent attempts to refine lambda87 and its precision have not reached a consensus. This thesis describes a new experiment to measure lambda87 by 87Sr accumulation over a period of about 30 years, and the preparation of a 84-86Sr double-spike in conjunction with that experiment. Radiogenic 87Sr produced in aliquots of a RbClO4 salt was measured by isotope dilution thermal ionization mass spectrometry. An average of 31 measurements yields a value of 1.398 ± 0.003 × 10-11a-1 . This requires a substantial revision from the previously accepted decay constant and makes Rb-Sr ages calculated with it 1.5% older. A Rb-Sr and U-Pb isotopic chronometry study was carried out on thirteen ordinary chondrites – the most common type of meteorite, the origin and history of which are still unclear. Some meteorites appear disturbed, possibly by recent shock during breakup of the parent body, whereas others yielded accurate and precise U-Pb and Pb-Pb ages. For example, L5 Elenovka yielded distinct ages for silicates (4555 Ma) and phosphates (4535 Ma), allowing the cooling rate of this meteorite from approximately 1055 K to 759 K to be constrained to 15 ± 3 K/Ma. Rb-Sr yielded less precise ages than U-Pb, but using the new decay constant allows accurate comparison between the two methods. This study creates a firm foundation for future studies in thermal history of chondrites and terrestrial metamorphic complexes using Rb-Sr together with other isotopic chronometers.
A Population Based Approach to Diabetes Mellitus Risk Prediction: Methodological Advances and Practical Applications
Keywords: diabetes
population risk prediction

Since the publication of the Framingham algorithm for heart disease, tools that predict disease risk have been increasingly integrated into standards of practice. The utility of algorithms at the population level can serve several purposes in health care decision-making and planning. A population-based risk prediction tool for Diabetes Mellitus (DM) can be particularly valuable for public health given the significant burden of diabetes and its projected increase in the coming years. This thesis addresses various aspects related to diabetes risk in addition to incorporating methodologies that advance the practice of epidemiology. The goal of this thesis is to demonstrate and inform the methods of population-based diabetes risk prediction. This is studied in three components: (I) development and validation of a diabetes population risk tool, (II) measurement and (III) obesity risk. Analytic methods used include prediction survival modeling, simulation, and multilevel growth modeling. Several types of data were analyzed including population healthy survey, health administrative, simulation and longitudinal data. The results from this thesis reveal several important findings relevant to diabetes, obesity, population-based risk prediction, and measurement in the population setting. In this thesis a model (Diabetes Population Risk Tool or DPoRT) to predict 10-year risk for diabetes, which can be applied using commonly-collected national survey data was developed and validated. Conclusions drawn from the measurement analysis can inform research on the influence of measurement properties (error and type) on modeling and statistical prediction. Furthermore, the use of new modeling strategies to model change of body mass index (BMI) over time both enhance our understanding of obesity and diabetes risk and demonstrate an important methodology for future epidemiological studies. Epidemiologists are in need of innovative and accessible tools to assess population risk making these types of risk algorithms an important scientific advance. Population-based prediction models can be used to improve health planning, explore the impact of prevention strategies, and enhance our understanding of the distribution of diabetes in the population. This work can be extended to future studies which develop tools for disease planning at the population level in Canada and to enrich the epidemiologic literature on modeling strategies.
Negative Regulatory Mechanisms Underlying EPO Receptor Signaling and Erythropoiesis
Keywords: Erythropoietin
Cbl

Erythropoietin (EPO) is the primary cytokine regulator of erythropoiesis. Fundamental to this action is the ability of EPO to bind the EPO receptor (EPO-R), and activate the primary associated tyrosine kinase, JAK2. The critical importance of EPO, EPO-R and JAK2 to erythropoiesis is demonstrated by the fatal embryonic anemia that develops upon EPO, EPO-R or JAK2 deletion. Positive regulation of intracellular signal transduction pathways downstream of EPO-R and JAK2 are well documented, but less is known about negative regulation of EPO-R signaling. Two distinct experimental strategies were utilized to examine a subset of the negative regulatory mechanisms underlying EPO-R signaling and erythropoiesis. Mice deficient in the E3 ubiquitin ligase, Cbl, were generated previously and displayed elevated platelet numbers, expansion of splenic red pulp and splenomegaly, suggesting that Cbl-/- mice have defects in megakaryocyte/erythrocyte progenitors or more committed cells of each lineage. Our studies illustrated that genetic ablation of Cbl resulted in elevated total numbers of Burst Forming Unit-Erythroid and Colony Forming Unit-Erythroid, but decreased bone marrow-derived late erythroblasts. Cbl-deficient late erythroblasts displayed elevated apoptosis, as well as increased expression of Foxo3a and increased mRNA levels of the pro-apoptotic genes, Bim and FasL. These studies implicate Cbl as an important negative regulator of multiple facets of erythroid signaling. The discovery that EPO-R is ubiquitinated and degraded by the proteasome and lysosome led us to examine the role of EPO-R ubiquitination on signal transduction and proliferation. Lysine mutagenesis of EPO-R showed that K348, K388 and K428 were the primary ubiquitin acceptor sites when EPO-R mutants were expressed in HEK 293T cells. BaF3 cells expressing an EPO-R deficient in cytoplasmic lysines displayed diminished EPO-mediated EPO-R, JAK2, PKB and STAT5 phosphorylation and could not proliferate in response to EPO. The membrane proximal lysines of EPO-R, K256 and K276, were necessary for proliferation at physiologic EPO concentrations but were not required at saturating EPO concentrations. Single lysine EPO-R add-back mutants restored signaling and proliferation to BaF3 cells at physiologically elevated EPO concentrations, signifying that EPO-R lysines finely mediate EPO-dependent proliferation and signal transduction. These analyses demonstrate a positive regulatory role for lysines in signal transduction and proliferation.
Parity Forwarding for Relay Networks
Keywords: communications
relay channel
information theory
coding

In this dissertation, we introduce a relay protocol for multiple-relay networks called parity forwarding. The relay channel is a classic multiuser information theory problem introduced in 1971, modeling a network of three nodes: a source, a destination, and a relay node. The relay has no message of its own and assists the source to communicate to the destination. Of the two main coding techniques for the relay channel, decode-and-forward (DF) and compress-and-forward (CF), our focus is to understand the DF scheme for single- and multiple-relay channels. For the single-relay channel, we present an interpretation of the classic DF strategy from a linear-coding perspective. Identifying binning in the classic DF strategy as parity bit generation, we devise ensembles of low-density parity-check (LDPC) codes, called bilayer LDPC codes, to incorporate the parity bits generated by the relay in the decoding process at the destination. We develop code design techniques and optimize the parameters of the bilayer LDPC code structure to show that bilayer LDPC codes can approach the theoretical DF rate. Inspired by the relation between binning and parity bits, we introduce the parity forwarding protocol to improve on the achievable DF rate in a multiple-relay network. For a two-relay network, we show that the previous multihop DF protocol can be improved if the relays forward parity messages and receivers (relays or the destination)use a joint decoding scheme. Depending on the relation between relay messages and decoded messages at each relay, different parity forwarding protocols are possible. In this thesis, we present a structured characterization of a class of parity forwarding protocols for multiple-relay networks. We propose a tree structure to describe the relations between messages. Using this tree structure, we derive a closed-form expression for the parity forwarding rate in a relay network with an arbitrary number of relays. Finally, examples of new types of degraded multiple-relay networks are presented for which the parity forwarding protocol achieves capacity.
Managerial Discretion, Corporate Financial Flexibility, and Investment Dynamics
Keywords: Corporate Failure
Bankruptcy
Mergers and Acquisition
Excessive continuation

In this dissertation, I try to advance our understanding of how managerial discretion and corporate financial flexibility affect various corporate outcomes such as failure, excessive (sub-optimal) continuation, firm growth and investment, in three novel ways. First, I show that the empirical effect of finance is not merely a misspecified real influence but rather that the financial structure of firms matter for firm growth and investment where the real effects of finance arise out of the imperfect substitutability between internal funding and external private credit. Second, using managerial mergers and acquisitions (M&A) investment decisions as an identification mechanism, I find that managerial discretion combined with corporate financial flexibility may lead to distortions in corporate investment and financing policies, and those distortions cost the various stakeholders of the firm dearly. Furthermore, using another sample of distressed firms worth more dead than alive, I, along with a co-author, show that most of these firms continue operations long after the optimal exit time. The failure to liquidate costs the typical sample firm over three years 8.7% of its assets in lost earnings relative to the industry median. Finally, I find that capital market does not fully internalize the costs associated with managerial sub-optimal behaviors in the short run. Although the market disciplines managerial sub-optimal behaviors in the long run, the market disciplinary mechanisms may not be swift enough to forestall falling values for the various stakeholders of the firm. Succinctly, the findings in this dissertation suggest that managerial discretion and corporate financial flexibility entail real consequences for various firm dynamics. The traditional line of argument, ``Blame It on the Market," may not be well grounded, and firms need to carefully examine their investments and financing policies in good times to cushion against systematic shocks in bad times.
Equality of Cultural Identity
Keywords: equality
identity
constitutional law
multiculturalism
language rights
freedom of religion
group rights

I address claims of offence of feelings, religious freedom and language rights, which are all justified by the intrinsic interest individuals attach to their culture. I call them ‘claims from cultural identity’. I develop a conception of substantive equality, understood as distributive justice and underpinned by dignity, for regulating claims from cultural identity in the legal system of multicultural states. I call it Equality of Cultural Identity. It is a ‘complex equality’ model, which takes cultural identity to be a sphere in peoples’ lives. Unlike majority members, cultural minority members are usually under constant pressure to compromise their cultural identity and assimilate in the majority culture to succeed in other spheres of their lives like education and career. In accordance with Walzer’s theory of Spheres of Justice, I propose a regulative principle to determine the extent of cultural protection minority members deserve, according to which the influence of other spheres of their lives on their sphere of cultural identity should as minimal as possible. I apply this principle to claims of offence to feeling, which I re-conceptualize as claims from integrity of cultural identity. I suggest the vulnerable identity principle: The more vulnerable a person’s cultural identity, the stronger her claim from integrity of cultural identity. This principle enhances a just distribution of symbolic goods between majority and minority members, is based on objective evaluation standards, and avoids legal moralism. Thus, it overcomes the major liberal worries about regulating speech. With respect to the language rights and religious freedom, I comparatively analyze them qua cultural rights. I argue that the right to religious freedom, which is generously interpreted by courts, bears all of the allegedly unique features of language rights that are used to support their restrained judicial interpretation. Thus, the existing arguments for their restrained interpretation are not valid. I identify a novel argument for their restrained interpretation, which is that they impose a cultural burden on majority members, but drawing on my conception of equality, I argue that it is not sound as the burden they impose is not great.
A New Taxonomy for Star Scientists: Three Essays
Keywords: star scientists
human capital

It is surprising that the prevailing performance taxonomy for scientists (Star versus Non-Star) focuses only on individual output and ignores social behavior since scholars often characterize innovation as a communal process. To address this deficiency, I expand the traditional taxonomy that focuses solely on productivity and add a second, social dimension to the taxonomy of scientists: helpfulness to others. Using a combination of academic paper citations and Impact Factor-weighted publications to measure scientist productivity as well as the receipt of academic paper acknowledgements to measure helpfulness, I classify scientists into four distinct categories of human capital quality: All-Stars, who have both high productivity and helpfulness; Lone Wolves, who have high productivity but average helpfulness; Mavens, who have average productivity but high helpfulness; and Non-Stars, who have both average productivity and helpfulness. The first study examines the impact of 415 immunologists on the performance of their coauthors. Looking at the change in quality-adjusted publishing output of an immunologist's coauthors after the immunologist's death, I find that the productivity of an All-Star's coauthors decreases on average by 35%, a Maven's coauthors by 30% on average, and a Lone Wolf's coauthors by 19%, all relative to the decrease in productivity of a Non-Star's coauthors. These findings suggest that our current conceptualization of star scientists, which solely focuses on individual productivity, is both incomplete and potentially misleading as Lone Wolves may be systematically overvalued and Mavens undervalued. The second study builds upon the first study's finding that Mavens have a large impact on the performance of their coauthors. Using salary disclosures from 2008 at the University of California, I examine the extent to which each star type is compensated differently. While Mavens have a larger impact on the performance of their coauthors than Lone Wolves, Mavens are compensated less, providing preliminary evidence that these performance effects are spillovers. The third study examines the likelihood of an immunologist's mobility as a function of his observable and unobservable human capital. The greater a scientist's productivity (observable to the market), the greater his inter-institution mobility, while the greater a scientist's helpfulness (unobservable to the market), the lower his inter-institution mobility.
Extractive Product Line Requirements Engineering
Keywords: Requirements Engineering
Software Product Lines
Functional Requirements Profiles
Software Engineering

A software product line (SPL) succeeds because we exploit the similarities between a set of software-intensive systems, together with an understanding of their differences, to reduce development cost, maintenance cost, and user confusion. In SPL engineering, reuse is planned, enabled, and enforced. It is through the development of a set of core assets that reuse is systematically practiced. Requirements assets enhance the effectiveness of reuse since engineers can work on the abstractions closer to the systems' initial concepts. Contemporary SPL requirements engineerin (RE) approaches often adopt the proactive model to build a relatively complete and stable asset base. In practice, the substantial up-front effort and the abrupt transition from existing practices associated with the proactive model present a prohibitive SPL adoption barrier for many organizations that could otherwise benefit. The extractive model overcomes these shortcomings by reusing existing products for the SPL's initial baseline. In this thesis, we present a framework for applying lightweight techniques to extract, model, and analyze a SPL's requirements assets. We define the notion of functional requirements profiles (FRPs) according to the linguistic characterization of a domain's action-oriented concerns, and show that the FRPs can be extracted from a natural language document on the basis of domain-aware lexical affinities that bear a 'verb - direct object' relation. We model the extracted FRPs by analyzing their semantic cases and by extending the orthogonal variability model (OVM). We contribute a set of heuristic rules for uncovering the variation dimensions and dependencies, and discuss merging the OVMs extracted from multiple sources. We relate functional profiles to quality requirements via scenarios, and manage requirements interactions via concept analysis. We present two applications of FRPs to support some other activities in SPL engineering. We conduct several empirical studies to evaluate our framework. The results show that our approach allows the engineers to identify the domain elements more easily and develop the domain models more systematically. Our work fills the void with respect to extracting a SPL's requirements assets, and the main thrust of our work is to promote a set of lightweight, low adoption threshold techniques as a critical enabler for practitioners to capitalize on the order-of-magnitude improvements offered by SPL engineering.
The Mark of the State: Reading the Writing of 'Right' in Hegel's Political Philosophy
Keywords: Hegel's Philosophy of Right
Derrida
Ethics
Politics

This project is a critique of the connection between lethal violence and justice within Hegel’s Philosophy of Right. Our critique focuses on three specific moments—moments that Derrida touches upon in Glas, but does not address in detail—namely, heroic vengeance, execution and warfare. By subjecting each of these moments to a close reading we will be calling into question the very possibility of an act of violence that can lay claim to being absolutely ‘necessary’ or ‘just’ either within its specific historical moment or from beyond it. The theoretical basis of the project closely parallels Jacques Derrida’s work on Hegel, in that it stems from a deconstruction of the connection between epistemology and ontology. This also has serious implications for the question of ethics. By tracing the play of différance through the semeiological structure of both theoretical and practical cognition Derrida’s work makes it possible to address the ethical implications of speculative dialectics from a non-dialectical angle. Figuratively speaking, the relationship between theoretical and practical cognition can be thought of as the relationship between reading and writing. As such, the title of the project is to be taken as a figurative reference to the connection between theoretical (i.e. reading) and practical (i.e. writing) cognition and by extension to the connection between epistemology, ontology and ethics. Addressed in this manner our project begins by tracing the silence (i.e. the ‘a’ of différance) that is, at one and the same time, a condition of the possibility and impossibility of meaning. This silence has serious ramifications for Hegel’s political philosophy. Hegel’s system sets out to ground the law within the ‘positive’ infinity of the Concept [Begriff] and thus, close the circle of philosophy. This project will attempt to expose the ethical stakes—and the ultimate impossibility—of Hegel’s ‘positive’ infinity by taking up the thread of lethal violence in the Philosophy of Right.