VictorJuiz/thesis huggingface dataset:
The Practice of Voting: Immigrant Turnout, the Persistence of Origin Effects, and the Nature, Formation and Transmission of Political Habit
Keywords: voting
turnout
immigrant political participation
immigrant integration
political socialization
social learning theory
observational learning
action theory
practice theory
culture
habit
dual-process cognition

This dissertation is a multi-layered examination of the practice of voting, with a focus on the electoral turnout of immigrants. Chapter Two’s statistical analyses show that pre-migration cultural familiarity with democracy, formalized as levels of democratization in source countries, strongly shapes the likelihood of post-migration voting among Canadian immigrants. These origin effects, comparable in size to the best predictors of turnout that we have, exert a persistent influence – affecting turnout not only among the foreign-born, but also among the native-born second generation. Multilevel models demonstrate that the shifting source country composition of immigrant period-of-arrival cohorts provides an alternate explanation for what have previously been identified as generational, racial, and length of residence or ‘exposure’ effects among immigrant voters. This provides further evidence that voting is in most cases habitual, and raises questions about the acquisition, transmission, and reproduction of a voting practice. Chapter Three’s narratives of political development, gathered through in-depth, semi-structured interviews, confirm the importance of parental influence, and suggest that the ‘stickiness’ of practical capacities like voting may be the result of powerful processes of observational social learning. Providing a new twist on dominant models of political socialization, observation of parental voting appears to be the pivotal event in a path-dependent process of political learning, with acquisition of values and beliefs playing a supporting, rather than a leading role. Chapter Four reviews recent efforts among sociologists to amend action theory to make more room for habit, and these efforts are discussed in reference to contemporary research on turnout. I argue that these theoretical revisions still retain too sharp a focus on the cognitive aspects of practice. There is a lack of appreciation for the ways that action itself – our own previous actions and the actions of those close to us – can directly structure outcomes. Evidence from cognitive neuroscience is used to more precisely delineate habitual behaviour and thought. Where the intergenerational transmission of voting behaviour is concerned, culture is often coded directly into embodied practice. Efforts to encourage electoral participation should be built on a better understanding of voting’s substantial behavioural aspects.
Low Regularity Stability for Subcritical Generalized Korteweg-de Vries Equations
Keywords: stability
Korteweg-de Vries equation

In this thesis we prove polynomial-in-time upper bounds for the orbital instability of solitons for subcritical generalized Korteweg-de Vries equations in [special characters omitted](R) with s < 1. By combining coercivity estimates of Weinstein with the I-method as developed by Colliander, Keel, Staffilani, Takaoka, and Tao, we construct a modified energy functional which is shown to be almost conserved while providing us with an estimate of the deviation of the solution from the ground state curve. The iteration of the almost conservation law for the modified energy functional over time intervals of uniform length yields the polynomial upper bound.
Development of Protein-based Tools to Image and Modulate Ca2+ Signaling
Keywords: Calcium Signaling
FRET Biosensors
Store Operated Calcium Entry
Stim1
Orai1
Optogenetics
Photo-activated
LOVS1K
Fusion Proteins
Protein Engineering

Optogenetics has emerged as a branch of biotechnology that combines genetic engineering with optics to observe intracellular changes as well as control cellular function. Despite recent progress, there still remains the need for an optogenetic tool that can specifically control Ca2+. Such a tool would greatly facilitate the study of highly Ca2+-dependent cellular processes that are regulated both spatially and temporally. Ca2+ signaling regulates many cellular processes in both healthy and diseased cells. The ability to modulate the shape, duration, and amplitude of Ca2+ signaling is important for elucidating mechanisms by which endogenous Ca2+ concentrations are maintained. In this thesis, we used optogenetic approaches to explore a number of strategies to control Ca2+ influx through store-operated Ca2+ entry (SOCE) mediated by Stim1 and Orai1. To better study Ca2+ signaling in live cells, protein-based biosensors can be developed to monitor intracellular Ca2+ changes. To aid in this, we developed a computational modeling tool called FPMOD to improve both new and existing biosensor designs. Although FPMOD was initially intended for evaluating biosensor designs, other research groups have since used it to construct models of other proteins to answer questions related to protein conformation. We next studied the modulation of SOCE by using drug-inducible fusion proteins to study the regulation of Stim1 puncta formation. Interestingly, recruiting a Ca2+-buffering protein to Stim1 led to puncta formation, a previously unknown means of inducing puncta. These results suggest Stim1 may additionally be regulated by cytoplasmic Ca2+ levels. Finally, we developed LOVS1K, an optogenetic tool to directly activate Orai1 channels and specifically control Ca2+ influx. Photo-sensitive LOVS1K was used to generate both local Ca2+ influx at the membrane and global cytoplasmic Ca2+ signals. As proof of concept, LOVS1K was further used to modulate engineered Ca2+-dependent proteins. Ca2+ is a remarkably versatile intracellular messenger. The combination of high spatiotemporal control of irradiation and the ability of LOVS1K to generate both local and global Ca2+ changes provides a promising platform to study cellular processes that are highly dependent on different Ca2+ signals. Together, biosensors and engineered Ca2+-modulating tools can be used to study the many different aspects of Ca2+ signaling and controllably manipulate endogenous Ca2+ signaling pathways.
Headache Experience of the Child and the Adolescent with Shunted Hydrocephalus
Keywords: child
adolescent
headache
hydrocephalus

Hydrocephalus is a common pediatric neurosurgical condition affecting the body’s ability to regulate cerebral spinal fluid. Treatment commonly involves insertion of a ventriculoperitoneal (VP) shunt re-establishing cerebral spinal fluid flow. Shunts are prone to malfunction, with headache being a common symptom. Headache has predominantly been recognized as a sign of shunt malfunction and not seen as a pain event. While headache is common in pediatric hydrocephalus patients with an apparently functional shunt, it has not been rigorously investigated putting them at risk for the consequences of unresolved pain. Researchers have not addressed headache within this patient population outside of shunt functioning or the impact of headache from the child and adolescent perspective. Drawing on the Gate Control Theory, the Neuromatrix Theory of Pain and the International Headache Societies Headache Classification system, a mixed methods study design was undertaken to (a) determine the prevalence, frequency and nature of headaches, (b) describe potential child factors associated with headaches and (c) evaluate the impact of headaches on the child’s and adolescent’s’ school, social and family life. Sixty six percent of children and adolescents reported headache within a one month period. Based on the modified International Headache Society’s criteria, 13.0% of headaches were tension-like, 13.2% were unclassifiable 33.5% were migraine-like and 38.8% were mixed. Etiology was significant with children diagnosed with tumour and congenital without myelomeningocele having a decreased tendency to report headache compared to children diagnosed with congenital with myelomeningocele. Children and adolescents described hidden emotions and missing out on many of their school, social and family activities. The main themes from the qualitative analysis were invisibility, normalcy and control/out of control. Etiology and multiple psychosocial and psychological factors potentially influence the headache experience in children and adolescents with shunted hydrocephalus. Future studies are required to further explore and delineate factors impacting headache within this study population.
The Bridging Education and Licensure of International Medical Doctors in Ontario: A Call for Commitment, Consistency, and Transparency
Keywords: international medical doctors
international medical graduates
IMGs
immigrant
bridging education
personnel selection: methods
interviews as topic
certification
education
Canada
licensure
internationally educated professionals
poetry
poetic representation
communication
residency interview
foreign medical graduates
qualitative research
physicians
english language proficiency
Vygotskian sociocultural theory
L. Vygotsky
activity theory

The widely acknowledged doctor shortage in Canada has recently motivated a more critical look at the licensure rates of International Medical Doctors (IMDs), also known as International Medical Graduates (IMGs). However, very little research has been conducted on the experiences of IMDs before they enter the Canadian medical system. This qualitative study collected interview data from 15 diverse IMDs seeking licensure in Ontario, Canada. The participants varied with respect to age, country of origin, English language proficiency on arrival, and time in Canada. In addition, two bridging support programs were observed, and interviews were conducted with three educators from the programs. The interviews were analysed using thematic content analysis (Boyatzis, 1998; Miles & Huberman, 1994). An analysis of metaphors used by the IMDs to describe their experiences during the licensing process supported the use of poetic representation for key findings, resulting in three poems that are interspersed in the body of the thesis (Ellingson, 2011; Glesne, 1997; Richardson, 2002; Richardson & Adams St. Pierre, 2005). The theoretical framework of the research was informed by Vygotskian Sociocultural Theory, which views learning as inseparable from social interaction and context (Vygotsky, 1987). Third-generation Activity Theory (AT), which has descended from Vygotsky’s work, was applied to highlight the higher-level systemic issues related to medical licensing. Results of this study indicate that IMDs with lower English proficiency face substantial difficulties on arrival, with limited access to the type of medically-relevant language instruction needed to support them. In fact, all pre-licensure IMDs struggle to access the interactional learning opportunities (i.e., Vygotskian “mediational means”) to support their entry into the system. Licensing challenges include limited exam preparation resources that support acquisition of Canadian cultural content; unequal access to clinical observerships; and a selection process which lacks transparency and emphasizes a screening tool unfamiliar to IMDs, the residency interview. Implications of this study include the revisiting of immigration policy; increasing the transparency and effectiveness of the selection process/residency interview; reviewing the role of clinical observerships in the selection process and exploring the potential of observerships to function as a licensure portfolio assessment.
Dissolution of Valuable Metals from Nickel Smelter Slags by Means of High Pressure Oxidative Acid Leaching
Keywords: slag leaching
fayalite dissolution
pyrrhotite oxidation
ressure oxidative leaching
free acid measurements
conductivity measurements
dissolution of silicates
autoclave leaching

In the production of base metals by smelting of sulphide ore concentrates, large amounts of iron are rejected with iron silicate slags. These slags contain Ni, Cu and Co in concentrations up to several percent units. Extraction of the entrapped base metals using high pressure oxidative acid leaching (HPOXAL) was investigated in this work. Crystalline slags containing fayalite (Fe2SiO4), magnetite (Fe3O4), silica (SiO2) and matte (MeSn<1) were found to be highly amenable to leaching at 250°C, 90 psi (6.2 bar) O2 partial pressure and 70 g/L initial H2SO4. Extractions of Ni, Co and Cu exceeded 90% within 15-20 min and arrived at 95-97% after 45 min. The residues of leaching were identified as aggregates of crystalline hematite (Fe2O3) and amorphous silica. Dissolution of fayalite and magnetite was shown to be acid driven. Since HPOXAL operates with substoichiometric additions of sulphuric acid (10-20% of the stoichiometric requirement), acid regeneration facilitated by iron oxidation and hydrolysis is crucial to high rates of leaching. Low acidities (<10 g/L) were shown to cause precipitation of ferrous sulphate, slowing acid regeneration and slag dissolution. Elevated acidities (>70 g/L) result in excessive concentrations of Fe(III) in the leach solution, complicating downstream processing. The use of pyrrhotite tailings, an environmentally hazardous waste, as a substitute of sulphuric acid in slag leaching was investigated. Oxidative co-leaching of pyrrhotite tailings with naturally cooled converter slag at 250°C, 90 psi (6.2 bar) O2, 68 g/L equivalent H2SO4 was shown to have kinetics comparable to adding sulphuric acid with final extractions reaching 95-97% in 45 min. Granulation of slag melt can produce an amorphous solid solution of SiO2 and metal oxides. Amorphous slag is not amenable to HPOXAL due to the formation of a passive layer of silica. Leaching of amorphous slag at low temperatures was shown to proceed nearly to completion. The difference in the leachability of amorphous slag at high and low temperatures is explained in terms of the rate of silicic acid re-polymerization leading to closure of pores in the leached layer.
Characterization of TCP genes in Arabidopsis thaliana
Keywords: Arabidopsis
TCP genes

TCP genes comprise a large family of genes that have been implicated in a diverse range of plant developmental pathways ranging from lateral branching (Doebley et al, 1997) to organ symmetry (Luo et al, 1999) and leaf curvature (Nath et al, 2003; Palatnik et al, 2003). I studied three closely related Arabidopsis TCP genes, one of which was recovered in an enhancer trap screen to identify downstream targets of the regulator of inflorescence architecture, BREVIPEDICELLUS (Douglas and Riggs, 2005). The enhancer trap marker line served as a reporter for TCP15 expression. Data mining has revealed a possible link between TCP15 and the hormone auxin. Using the DR5::GUS molecular reporter for auxin accumulation I found that TCP15 and the related TCP14 genes limit auxin maxima in seedling and reproductive tissues and that auxin transport is necessary for correct TCP15 expression. The closely related TCP8 gene was found to regulate leaf shape as demonstrated by decreased leaf index values. The rounder leaves of tcp8 plants also exhibited increased adaxial trichome and stomatal densities resulting in significantly decreased spacing between adjacent cells. tcp8 leaves showed increased serration density suggesting that TCP8 limits marginal outgrowth. Vein patterning was also perturbed in the mutants. Vein loops were rounder and smaller, and decreased loop subdivision indicated that vein patterning is retarded in the mutant. TCP8 evokes organ-specific effects on vascular patterning as mutant rosette leaves showed increased vascular complexity, whereas mutant cauline leaves showed decreased vein complexity. These results suggest that TCP8 is necessary for correct leaf development. The Arabidopsis genome contains 24 TCP genes, many of which have not been characterized. Studies of these genes will lead to the identification of additional factors necessary to control plant architecture and enable us to optimize plant growth and yield using genetic engineering.
Structural Results on Optimal Transportation Plans
Keywords: optimal transportation
Monge-Kantorovich problem
calculus of variations
mathematical economics
Lipschitz submanifolds
rectifiability
principal-agent problem
multiple marginals
regularity of optimal maps
time-like submanifolds
semi-Riemannian metric

In this thesis we prove several results on the structure of solutions to optimal transportation problems. The second chapter represents joint work with Robert McCann and Micah Warren; the main result is that, under a non-degeneracy condition on the cost function, the optimal is concentrated on a n-dimensional Lipschitz submanifold of the product space. As a consequence, we provide a simple, new proof that the optimal map satisfies a Jacobian equation almost everywhere. In the third chapter, we prove an analogous result for the multi-marginal optimal transportation problem; in this context, the dimension of the support of the solution depends on the signatures of a 2m -1 vertex convex polytope of semi-Riemannian metrics on the product space, induce by the cost function. In the fourth chapter, we identify sufficient conditions under which the solution to the multi-marginal problem is concentrated on the graph of a function over one of the marginals. In the fifth chapter, we investigate the regularity of the optimal map when the dimensions of the two spaces fail to coincide. We prove that a regularity theory can be developed only for very special cost functions, in which case a quotient construction can be used to reduce the problem to an optimal transport problem between spaces of equal dimension. The final chapter applies the results of chapter 5 to the principal-agent problem in mathematical economics when the space of types and the space of available goods differ. When the dimension of the space of types exceeds the dimension of the space of goods, we show if the problem can be formulated as a maximization over a convex set, a quotient procedure can reduce the problem to one where the two dimensions coincide. Analogous conditions are investigated when the dimension of the space of goods exceeds that of the space of types.
Evaluating the Harm of Drugs in the Post-marketing Environment using Observational Research Methods
Keywords: Drug Safety
Pharmacoepidemiology

Our knowledge of a drug’s potential for harm is incomplete at the time of drug licensing leaving residual questions about the long-term safety and effectiveness of drugs in the ‘real world’. Pharmacoepidemiologic research can contribute to the study of the unintended effects of drugs. The central aims of this dissertation were to create new knowledge about drug-related harm in the postmarketing environment using pharmacoepidemiologic methods and larged linked databases, and understand how various types of design and analytic strategies can be applied to reduce bias and threats to internal validity when studying drug harm. The aims of the thesis were achieved by performing three studies. The first study examined elderly individuals hospitalized with bradycardia and identified an association with recent initiation of cholinesterase inhibitor therapy (adjusted odds-ratio 2.13, 95% confidence interval 1.29 to 3.51). The second study examined the measurement properties of administrative diagnostic codes for subtrochanteric and femoral shaft fractures and found the positive predictive value and sensitivity of the codes to be reasonably good (90% and 81%, respectively). This study was linked to the third study which explored the association between long-term bisphosphonate use and subtrochanteric or femoral shaft fractures in postmenopausal women and found an increased risk of these unusual fractures in women with greater than 5 years of bisphosphonate use. The research performed as part of this thesis provides an example of the types of new knowledge about drug-related harm that can be generated using pharmacoepidemiologic designs and analytic strategies. The pharmacoepidemiologic studies will play an important and dynamic role in the larger evolving focus on post-marketing drug safety and effectiveness as new data sources become increasingly available and and the methods within the pharmacoepidemiologic discipline become more sophisticated and refined.
Hierarchical Bayesian Models of Verb Learning in Children
Keywords: Computational linguistics
Language acquisition
Bayesian models

The productivity of language lies in the ability to generalize linguistic knowledge to new situations. To understand how children can learn to use language in novel, productive ways, we must investigate how children can find the right abstractions over their input, and how these abstractions can actually guide generalization. In this thesis, I present a series of hierarchical Bayesian models that provide an explicit computational account of how children can acquire and generalize highly abstract knowledge of the verb lexicon from the language around them. By applying the models to large, naturalistic corpora of child-directed speech, I show that these models capture key behaviours in child language development. These models offer the power to investigate developmental phenomena with a degree of breadth and realism unavailable in existing computational accounts of verb learning. By most accounts, children rely on strong regularities between form and meaning to help them acquire abstract verb knowledge. Using a token-level clustering model, I show that by attending to simple syntactic features of potential verb arguments in the input, children can acquire abstract representations of verb argument structure that can reasonably distinguish the senses of a highly polysemous verb. I develop a novel hierarchical model that acquires probabilistic representations of verb argument structure, while also acquiring classes of verbs with similar overall patterns of usage. In a simulation of verb learning within a broad, naturalistic context, I show how this abstract, probabilistic knowledge of alternations can be generalized to new verbs to support learning. I augment this verb class model to acquire associations between form and meaning in verb argument structure, and to generalize this knowledge appropriately via the syntactic and semantic aspects of verb alternations. The model captures children's ability to use the alternation pattern of a novel verb to infer aspects of the verb's meaning, and to use the meaning of a novel verb to predict the range of syntactic forms in which the verb may participate. These simulations also provide new predictions of children's linguistic development, emphasizing the value of this model as a useful framework to investigate verb learning in a complex linguistic environment.