VictorJuiz/thesis huggingface dataset:
Rhetoric and argument in John Stuart Mill's The Subjection of Women
Keywords: rhetoric
feminism
john stuart mill

This thesis uses John Stuart Mill's 1869 work The Subjection of Women as the basis for what Bernard Williams has called 'a philosophical description of an historical reality'. The Introduction argues that the 'feminist' political advocacy of the Subjection is inseparable from its directly philosophical content. The second chapter describes how Mill's text is best understood in terms of its aims, its constituency of implied readers, and the forms of argument and rhetoric it employs. The third chapter describes how Mill appeals to his readers' desire for consistency as well as to their deepest values and self-image in the course of his arguments. This chapter also examines Mill's use of the rhetorical technique of 'paradiastole', his argument against methodological conservatism, and his skilful use of arguments from analogy. The fourth chapter considers the relevance of Mill's Subjection to debates in contemporary feminism. The Conclusion reconsiders the question of how the study of history is relevant to the political philosopher.
The role of the G-protein subunit, G-alpha-11, and the adaptor protein 2 sigma subunit, ap2-sigma-2, in the regulation of calcium homeostasis
Keywords: Calcium sensing receptor
G protein coupled receptor

The calcium sensing receptor (CaSR) is a G-protein coupled receptor (GPCR) that plays a central role in calcium homeostasis. Loss-of-function mutations of the CaSR cause familial hypocalciuric hypercalcaemia type 1 (FHH1), whilst gain-of-function mutations are associated with autosomal dominant hypocalcaemia (ADH). However, 35% of cases of FHH and 60% of cases of ADH are not due to CaSR mutations.
This thesis demonstrates that FHH type 2 (FHH2) and the new clinical disorder, ADH type 2 (ADH2), are due to loss- and gain-of-function mutations in the G-protein subunit, Gα11, respectively. The CaSR signals through Gα11 and FHH2-associated mutations are shown to exert their effects through haploinsufficiency. Three-dimensional modelling of ADH2-associated Gα11 mutations predicts impaired GTPase activity and increases in the rate of GDP/GTP exchange. Furthermore, mouse models of FHH2 and ADH2 have been identified and re-derived to enable in vivo studies of the role of Gα11 in calcium homeostasis.
I also demonstrate that FHH3 is due to loss-of-function mutations in the adaptor protein 2 sigma subunit, AP2σ2, which exert dominant-negative effects. AP2σ2 is a component of the adaptor protein 2 (AP2), which is a crucial component of clathrin-coated vesicles (CCV) and facilitates clathrin-mediated endocytosis of plasma membrane components such as GPCRs. All of the identified FHH3-associated mutations affect the Arg15 residue of AP2σ2, which forms key polar contacts with CCV cargo proteins. This thesis proposes that FHH3-associated AP2σ2 mutations impair CaSR internalisation and thus negatively impact on CaSR signalling. In addition, these studies show that these signalling defects can be rectified by the use of the CaSR allosteric modulator cinacalcet, which may represent a useful therapeutic modality for FHH3 patients.
In summary, FHH2 is due to loss-of-function mutations in Gα11 causing haploinsufficiency, whilst FHH3 is due to loss-of-function mutations in AP2σ2, which exert dominant-negative effects. In contrast, ADH2 is due to gain-of-function mutations in Gα11.
Gambling-think
Keywords: pathological gambling

Background: Cognitive perspectives suggest that gambling-related cognitive (GRC) biases contribute to the development and maintenance of gambling problems. Evidence has since accumulated to support these claims: GRCs tend to be stronger amongst problems (and pathological) gamblers, and can be effective therapeutic targets of talking treatments. However a richer account of how GRCs are conditioned by gamblers' game and group interactions might enhance their explanatory power and therapeutic value.
Methods: Here, I present the results of an extended programme of research involving: (i) laboratory-based experiments on action-based expressions of illusions of control (IOC; Studies 1-4) and value learning when making decisions under uncertainty (Study 5); (ii) online surveys of Chinese gamblers' participation patterns and beliefs in luck (Study 6); and finally, (iii) qualitative interviews of treatment-seeking professional footballers in the United Kingdom (Study 7).
Results: Studies 1-2 demonstrated that (non-problematic) gamblers displayed IOC biases by rolling a simulated die for longer when attempting to hit targets with larger prizes and numerical values. These action-based expressions of IOC were facilitated by congruent target numbers and prizes (Study 3), and heightened competition with gambling co-actors (Study 4). Additionally, computational models of gamblers' choices in Study 5 showed that self-report GRCs, and impulsivity, weaken gamblers' ability to learn the value of competing game options. Next, Study 6 reported that Chinese gamblers' GRCs were related to a broader range of gambling activities, and self-report IOCs mediated the association between beliefs in luck and the number of reported gambling problems. Finally, Study 7 found that social pressures, high income, and work-related frustrations precipitated problematic gambling involvement in treatment-seeking footballers.
Discussion: Overall, the results suggest that a richer account of GRCs can be achieved by considering the sensorimotor and sociocultural contexts of gamblers. My thesis concludes with a discussion of GRCs within more recent theoretical developments of the embodied and social cognitions paradigms.
Mathematical modelling of surfactant adsorption structures at interfaces
Keywords: Surfactants

In this thesis we derive and solve mathematical models for surfactant systems with differing adsorption structures at interfaces. The first part of this thesis considers two dynamic experimental set-ups for which we derive the associated mathematical surfactant–fluid description. Firstly we consider the behaviour of a weakly interacting polymer–surfactant solution under the influence of a steady straining flow. We reduce the model using asymptotic methods to predict the regimes under which we observe phase transitions of the species in the system and show how the bulk dynamics couple to the surfactant adsorption. Secondly we model an experiment to observe the desorption kinetics of a surfactant monolayer, designed to emulate the 'rinse mechanism' used for the removal of surfactant-containing products using water. Through the comparison of our model with experimental data we derive a semi-empirical relationship that describes the variation in depth of a near-surface diffusive boundary layer with the reduced Peclet number. We then employ a combination of asymptotic and numerical techniques that validate this result.
The second part of this thesis is concerned with surfactant systems that exhibit more pronounced adsorption at the interface due to the surfactant monomers no longer arranging themselves in a single layer, as is typically the case, but rather in multiple layers. Such self-assembled structures are commonly referred to as multilayers. We derive a simplified model that describes the rearrangement of surfactant within the multilayer structure and draw comparisons between the features of our model and experimental observations. We consider an extension of the theory to the situation of multilayer formation between two adsorbing interfaces, which is governed by an implicit free-boundary problem. We also consider incorporation of bulk solution effects, such as the addition of an electrolyte. Finally, we draw our conclusions and suggest further theoretical and experimental work related to the models presented in this thesis.
Essays on rural-to-urban migration and urban industrial performance in Sub-Saharan Africa
Keywords: Africa
demographic mobility
migration
productivity

This thesis consists of three independent but thematically related papers exploring the income determination process in African labour markets from spatial and sectoral perspectives.
Using long-run household panel data from rural Tanzania, chapter 2 investigates the extent to which education can explain migrants' income and consumption gains. We expect that the higher return to schooling at the destination primarily drives migrants' gains, suggesting that those who cannot afford the cost of schooling cannot reap the benefits of migration. We find that education indeed plays the role, but that it does not appear to be a major factor in limiting the internal migration as a source of raising income and consumption.
Exploiting data drawn from urban household panel surveys in Ghana and Tanzania, chapter 3 investigates how rural-to-urban migrants' earnings compare with those of natives in urban labour markets. The chapter attempts to identify the growth of migrants' earnings at the destination (assimilation), making a distinction between wage and self-employed migrants. We find that wage-dependent migrants would achieve higher lifetime earnings if they entered a self-employed sector from their arrival, conditional on individuals' attributes and the varying returns to those attributes across urban residents. The evidence points towards the importance of capital constraints in a decision to start a business.
Using firm-level data of manufacturing and retailing from the Enterprise Surveys conducted in seven Sub-Saharan African countries, chapter 4 attempts to improve our understanding of enterprise performance in urban Africa by investigating three aspects of firms' productive structure: technology, total factor productivity (TFP), and firm size. We find that the technology is similar between sectors, that retailing firms are smaller and less capital intensive but not, on average, ones with lower TFP, and that TFP differences are primarily within sectors. All these findings might point towards the importance of factor prices in characterising the industrial structure in urban Africa.
The role of the 5-HT2C receptor in emotional processing in healthy adults
Keywords: serotonin
emotion processing
psychiatry

Serotonin (5-HT) has long been implicated in the pathophysiology of depression and anxiety, and the therapeutic effect of treatments. Several drugs useful in treatment produce either acute or neuroadaptive changes in 5-HT2C receptor activity, and there has been growing interest in how alterations in the 5-HT2C receptor might be important in mediating antidepressant and anxiolytic activity. The neuropsychological hypothesis of drug action implies that the clinical effects of medications active in anxiety and depression are best understood through the effects of these agents on the processing of emotional information. Thus far, however, there has been no systematic attempt to identify the role of the 5-HT2C receptor in drug-induced changes in emotional processing in humans. The current research therefore investigated the effects of drug treatments with 5-HT2C blocking properties on neural and behavioural responses to emotional information in healthy volunteers. An fMRI study demonstrated that a single dose of mirtazapine, an antidepressant with action at the 5-HT2C receptor, reduces activation in regions important in emotional processing, such as the amygdala and the fusiform gyrus, to threat-relevant stimuli. A series of behavioural studies utilized drugs acting, at least in part, as 5-HT2C antagonists and agonists to show that these drugs are able to alter emotional processing, particularly emotional memory. A seven-day administration of mirtazapine was shown to increase the recall of positive versus negative personality characteristics. A single dose of agomelatine, also an antidepressant with putative action at the 5-HT2C receptor, did not increase slow wave sleep, suggesting, the drug had no effect of 5-HT2C blockade in the brain. In Chapter 4, agomelatine and mCPP, a 5-HT2C agonist, also shown to had no significant effect on emotional processing measures, but there was a statistical trend for agomelatine to increase memory for positive stimuli, and for mCPP to increase memory for negative stimuli. These findings suggest that antidepressants may work by altering the bias in emotional processing. Overall, the results of this exploration of the role of the 5-HT2C receptor in emotional processing have contributed to the understanding of antidepressant treatment, and raise new possibilities for the continuation of study in this field.
Aziridinations of tethered allenes
Keywords: sulfamates
allenes
aziridines
rhodium
carbamates

This thesis describes the synthesis and reactivity of previously unprecedented bicyclic methylene aziridines via rhodium(II) catalysed cyclisation of α-allenic N-tosyloxycarbamates. These aziridines undergo reaction with organocuprates to give cis- disubstituted oxazolidinones by nucleophillic attack at the vinylic centre; plausible mechanisms for this process are discussed.
Similar rhodium(II) catalysed cyclisations of β-allenic sulfamates afford cyclic enamines, aminocyclopropanes or bicyclic methylene aziridines; the product ratio depends on the allene substitution pattern. Suitably-designed substrates undergo trapping of the proposed intermediate amino allyl cation by internal nucleophiles or by cycloaddition.
Finally, thermally-induced intramolecular cycloadditions of γ-allenic azides are described that give triazolines or [1,2,3]-triazoles.
Morphometric analysis of brain structures in MRI
Keywords: multiple sclerosis
segmentation
partial volume effect
medical image analysis
schizophrenia
magnetic resonance imaging

Medical computer vision is a novel research discipline based on the application of computer vision methods to data sets acquired via medical imaging techniques. This work focuses on magnetic resonance imaging (MRI) data sets, particularly in studies of schizophrenia and multiple sclerosis. Research on these diseases is challenged by the lack of appropriate morphometric tools to accurately quantify lesion growth, assess the effectiveness of a drug treatment, or investigate anatomical information believed to be evidence of schizophrenia. Thus, most hypotheses involving these conditions remain unproven.
This thesis contributes towards the development of such morphometric techniques. A framework combining several tools is established, allowing for compensation of bias fields, boundary detection by modelling partial volume effects (PVE), and a combined statistical and geometrical segmentation method. Most importantly, it also allows for the computation of confidence bounds in the location of the object being segmented by bounding PVE voxels. Bounds obtained in such fashion encompass a significant percentage of the volume of the object (typically 20-60%).
A statistical model of the intensities contained in PVE voxels is used to provide insight into the contents of PVE voxels and further narrow confidence bounds. This not only permits a reduction by an order of magnitude in the width of the confidence intervals, but also establishes a statistical mechanism to obtain probability distributions on shape descriptors (e.g. volume), instead of just a raw magnitude or a set of confidence bounds. A challenging clinical study is performed using these tools: to investigate differences in asymmetry of the temporal horns in schizophrenia. This study is of high clinical relevance. The results show that our tools are sufficiently accurate for studies of this kind, thus providing clinicians, for the first time, with the means to corroborate unproven hypotheses or reliably assess patient evolution.
Absolute and relative generality
Keywords: modal set theory
quantification
Absolute generality
indefinite extensibility
Russell's paradox
set theory
metasemantics
modality

This thesis is concerned with the debate between absolutists and relativists about generality. Absolutists about quantification contend that we can quantify over absolutely everything; relativists deny this. The introduction motivates and elucidates the dispute. More familiar, restrictionist versions of relativism, according to which the range of quantifiers is always subject to restriction, are distinguished from the view defended in this thesis, an expansionist version of relativism, according to which the range of quantifiers is always open to expansion.
The remainder of the thesis is split into three parts. Part I focuses on generality. Chapter 2 is concerned with the semantics of quantifiers. Unlike the restrictionist, the expansionist need not disagree with the absolutist about the semantics of quantifier domain restriction. It is argued that the threat of a certain form of semantic pessimism, used as an objection against restrictionism, also arises, in some cases, for absolutism, but is avoided by expansionism. Chapter 3 is primarily engaged in a defensive project, responding to a number of objections in the literature: the objection that the relativist is unable to coherently state her view, the objection that absolute generality is needed in logic and philosophy, and the objection that relativism is unable to accommodate ‘kind generalisations’. To meet these objections, suitable schematic and modal resources are introduced and relativism is given a precise formulation.
Part II concerns issues in the philosophy of mathematics pertinent to the absolutism/relativism debate. Chapter 4 draws on the modal and schematic resources introduced in the previous chapter to regiment and generalise the key argument for relativism based on the set-theoretic paradoxes. Chapter 5 argues that relativism permits a natural motivation for Zermelo-Fraenkel set theory. A new, bi-modal axiomatisation of the iterative conception of set is presented. It is argued that such a theory improves on both its non-modal and modal rivals.
Part III aims to meet a thus far unfulfilled explanatory burden facing expansionist relativism. The final chapter draws on principles from metasemantics to offer a positive account of how universes of discourse may be expanded, and assesses the prospects for a novel argument for relativism on this basis.
Old Norse visions of the afterlife
Keywords: Visiones
Old Norse Literature
Medieval Visions of the Afterlife

The nature of life after death is only tentatively sketched out in the canonical writings of the Christian Church, yet it represents one of the most prominent literary subjects in medieval Europe. The so-called Visiones represent a genre that enjoyed a particularly broad dissemination between the fourth and thirteenth centuries. This study aims to assess the impact of this Latin tradition on Norse-Icelandic authors and processes of cultural appropriation evident in medieval vernacular adaptations of the genre.
The first chapter outlines the historical and theological conditions surrounding the genre’s dissemination in Western Scandinavia and identifies the primary corpus of vernacular adaptations of the genre to be analysed in this study. Chapter II considers the literary contexts in which Visio-conventions have been integrated, highlighting the distinctive generic and creative diversity exhibited in the primary corpus. Chapters III and IV are concerned with the literary motif of the journey to the otherworld and its importance in Old Norse literary traditions across the period of Christianisation. The former examines signs of continuity on a conceptual level between traditional native and Christian narratives about the otherworld, suggesting that the journey motif represented a sustained source of literary creativity in pre- and post-conversion societies. The latter examines this notion of continuity with reference to two significant literary symbols, the otherworld shoe and the otherworld bridge, and their pregnant resonances in Norse Icelandic records of myth, law, and religious ritual; it will here be shown how certain symbols found in vernacular accounts of the afterlife produce a rich set of connotations meaningful within their particular cultural setting. The final Chapter analyses the social mentality encoded in portrayals of the idealised hereafter, and it will be argued that portrayals of eschatological justice and the topography of heaven reflect attitudes characteristic of the societies from which these visions emerge.
The thesis as a whole thereby calls attention to the broad and deep nature of the Visio genre’s impact on Western Scandinavian literary culture, suggesting that this particular genre-oriented study may serve as a case study of the reception of Christian literary traditions in medieval Iceland and Norway more generally.
The education of children of immigrants in Finland
Keywords: education
Finland
children of immigrants

This thesis considers the education of children of immigrants in Finland, focusing on attainment and transitions around the age of 16. It is the first detailed representative study on the topic in Finland. Compared to international research it is amongst the ones to most fully explore the different aspects of education around this age. For the most part, it is limited to studying structural explanations for differences between students and ethnic groups. The majority of the analyses in the thesis are done using register data. Statistical modelling of this data is done using multivariate regression analyses. The results are supplemented with evidence from interviews with both majority students and children of immigrants. With regards to school achievement at the end of comprehensive school, many immigrant-origin groups are seen to have lower average grades than the majority. However, this is explained by lower parental resources. After controlling for parental resources, very few disadvantages remain. On the other hand, the gender gap evident amongst the majority is not found amongst many immigrant-origin groups. Looking at continuation to upper secondary education compared to dropping out, most children of immigrants are seen to have a higher probability of dropping out than the majority. This is explained by their lower school achievement and higher parental non-employment. Nevertheless, the difference between children of immigrants and the majority remains evident at the very low end of the achievement scale. Considering the choice of upper secondary school type, children of immigrants can be seen to be more likely than the majority to continue to vocational school. Yet, after controlling for prior school achievement and parental resources, almost all immigrant-origin groups are more likely than the majority to continue to general rather than vocational school. Interviews suggest that when considering their school choices, majority students tend to be driven by their interests and see their decision making as being independent of others. On the other hand, children of immigrants tend to have more specific future plans and to take the wishes of their parents more into consideration.