VictorJuiz/thesis huggingface dataset:
Heavy Drinking Episodes and Heart Disease Risk
Keywords: alcohol drinking
heart disease
heavy episodic drinking
meta-analysis

Background: The relationship between average alcohol consumption and heart disease is well researched, showing a substantial cardioprotective association. This dissertation examined the epidemiological evidence for an effect of heavy episodic drinking (HED) over and above the effect of average alcohol consumption on heart disease. Methods: Electronic databases were systematically searched for epidemiological studies on the effect of HED on heart disease and identified articles were quantitatively summarized in a meta-analysis. Meta-regression models were used to examine the effect of characteristics of primary studies. Using individual-level data, semi-parametric Cox regression models were used to investigate HED exposure within narrow categories of average alcohol consumption in a US national population sample (n = 9,937) in relation to heart disease mortality in an 11-22 year follow-up. Frequency of heavy drinking episodes was used to identify latent classes of drinking history using growth mixture modeling in a sub-sample of this US cohort. Retrieved classes were used as independent variables in Cox regression models with heart disease mortality as the outcome event. Results: A pooled relative risk of 1.45 (95% confidence interval (CI): 1.24-1.70) for HED compared with non-HED drinkers with average alcohol consumption between 0.1-60 g/day was derived in a meta-analysis. A strong and consistent association with HED was found among current drinkers consuming an average of 1-2 drinks per day in the US cohort. There was no evidence of increased heart disease mortality resulting from the frequency of heavy drinking episodes before the age of forty. Conclusions: There is reasonable and consistent evidence for an association of HED and heart disease in current drinkers, negating any beneficial effect from alcohol consumption on heart health. History of frequency of heavy drinking episodes, however, showed no evidence for such an effect modification.
Idiosyncratic Distortions, Misallocation and TFP Losses
Keywords: Misallocation
Extortion

How resources are allocated across plants is crucial for understanding cross-country output and productivity differences. This thesis contributes to the growing literature on resource misallocation by studying the particular channels through which misallocation can arise. In Chapter 1, I examine extortion at the plant-level, its effects on individual incentives to become an entrepreneur, and how production is affected by the presence of extortion. I show that extortion is especially burdensome on moderate-ability entrepreneurs forcing them to either forgo entry into entrepreneurship or produce at an inefficiently small scale. When property rights are weak, the frequency of extortion is higher producing a society where much of it's entrepreneurial talent is heavily under-utilized. In Chapter 2, I study plant-level distortions and it's effects on incentives to improve productivity. I build a model where plant innovation improves future productivity so that productivity dynamics are endogenous. Distortions that are tied to productivity are introduced to the model to examine how plant innovation is affected. All plants lower innovation resulting in a distribution over productivity that is right-skewed and a distribution over plant size that is left-skewed, consistent with empirical findings in developing countries. The final Chapter is closely related to Chapter 1 but is more empirically focused. I study the role of theft as a means to explaining the abundance of small plants in developing countries and estimate the causal effect of theft on plant capital demand. I find that plant capital would be significantly higher if theft is eliminated.
Students' Heterogeneity and Multiple Worlds: Revisiting the Changing Student Poulations in Ontario
Keywords: secondary school students, diversity, identity,
school change

Abstract This qualitative study is designed to examine how the 8 university students (from 8 different secondary schools) define their high school experiences. The study focuses on how the 8 study participants’ unique identities shape their experiences of secondary schooling. The three paradigms, students’ heterogeneity, multiple worlds, and identity conceptually framed the study. Through the focus group interactions and two sets of individual interviews, each student’s unique identity and agency were revealed; both individual-social-collective entities that were developed in relations to others. The other sources of data were school websites, relevant media reports on schools and their communities, and policy documents on academic and international baccalaureate programs; finally, field notes were also taken. In so doing, the research critically explores participants’ voices on heterogeneity, multiple worlds of family, neighbourhood, peers,cultural and multicultural identities. Finally, the 8 young people also reflect on their 8 schools, their academic programs, overall educational experience, and particularly, how young people articulate their belonging in high schools. Findings of the study suggest that participants’ identities of who they were often echoed their class, race, and ethnicity, and in turn, affected their academic engagement and identity. Despite the public invitation of all schools on their websites for students to participate in the school communities, the participants painted an altogether different picture; not all adolescents had equal access to schooling. The study makes recommendations for policy-makers, schools, and their districts which address the issues of inequity raised in this study. Specifically, schools need to be aware of the cultural,socioeconomic, and ethnic issues and the challenges that are in the way of minority adolescents’ progress so that secondary schools can extend their support to low income and immigrant students.
Development and Evaluation of a Tailored Knowledge Translation Intervention to Improve Lay Health Workers Ability to Effectively Support TB Treatment Adherence in Malawi
Keywords: knowledge translation
lay health workers

Background: Task shifting provision of basic health care services to lay health workers (LHWs) is increasingly employed to combat the global shortage of skilled health workers, particularly in low and middle income countries, where the shortage is greatest. Despite evidence for the effectiveness of LHWs in improving access to basic health services and positively impacting a variety of health outcomes, questions remain as to how recognized weaknesses in training and supervision are best addressed. This thesis employed a sequential-concurrent mixed-methods design and is composed of 3 studies with the objective of designing and rigorously evaluating a knowledge translation (KT) intervention tailored to address identified barriers to LHWs ability to function optimally as TB adherence supporters in Zomba district, Malawi. Methods & Findings: The first study utilized the qualitative methods of focus groups and interviews conducted with LHWs routinely involved in provision of care to TB patients. Lack of TB knowledge and job-specific training were identified as the key barriers to LHWs in their role as TB adherence supporters. Based on these findings, a KT intervention was developed and tailored to the identified training gaps. The second study, evaluated the effectiveness of the intervention in improving TB treatment adherence in a cluster randomized controlled trial, which showed no evidence for effectiveness of the intervention. The third study, conducted concurrently with the cluster trial, employed qualitative interviews to explore LHWs experiences with the intervention to identify ii aspects of the intervention found to be helpful and areas in need of improvement. Study 3 found that the intervention was well received and valued, with reported benefits to LHWs through improved knowledge and skills, and increased confidence. Suggestions for improvement varied considerably, with an anticipated concern with the lack of stipends and conduct of training on-site, raised as an issue by a minority of participants. Conclusion: This thesis suggests that a multi-component KT strategy tailored to address local barriers, was well received and valued by LHWs, and may represent a cost-effective approach to LHW training. However, given the trend for effectiveness did not reach significance in this underpowered study, further research is needed.
Motor Performance in the Context of Externally-imposed Payoffs
Keywords: Motor Control
Statistical Decision Theory

Humans need to rapidly select movements that achieve their goal while avoiding negative outcomes. The processes leading to these decisions have only recently been studied. In the typical paradigm used to gain insight into the decision process, participants aim to a target circle that is overlapped by a penalty circle. They receive 100 points for hitting the target, and lose points for hitting the penalty region. Previous research has shown that participants generally behave like a rational decision maker by adapting their endpoint when the distance between the target and penalty circle and the penalty value changes (although some suboptimal selection has been noted). The overall purpose of the research reported in the present thesis was to determine if there are contexts when participants’ behaviour is suboptimal in a rapid, motor decision making tasks. Taken together, the results from four studies showed that: 1) participants require experience and feedback to aim to optimal locations; 2) participants often aimed closer to target center than optimal; and, 3) probability (represented through spatial parameters) has more influence over participant’s motor decisions than does the value of the penalty. Therefore, participants’ actions do not necessarily conform to a rational model of decision making; rather, there are consistent biases arising in the selection, planning, and execution of actions in specific contexts. These findings and conclusions can lead to a more descriptive understanding of motor decision making to provide information that is in addition to prescriptive models of rational behaviour.
Concerto for Cello, Orchestra, and Live Electronics
Keywords: Music
Orchestra
Live Electronics
Cello
Cello Concerto
Electroacoustic
Electronics

The present thesis comprises a musical score and a set of specifications for a programmer to employ in the creation of a computer patch required to run the electronics. Scored for symphony orchestra and solo cello, the work also incorporates a computer operator and sound engineer who function as performers, following detailed instructions to store, activate, shape, spatialize, and regulate electronic material. The computer patch manifests two main components: the recording and playback of live sound (with the solo cello acting as the input source) and a virtual instrument feedback module. Electronic superimpositions of solo cello samples, ranging in density between a single layer and many simultaneous layers, intertwine with the live instrumentalist, forming timbrally distinct polyrhythmic contrapuntal lines. The feedback component allows for an interaction between the soloist and electronics, in which the computer operator manipulates faders connected to a series of feedback sub-patches, each employing a range of diverse delay parameters. The musical language of the work, which evolves from a series of expanding and contracting pitch clusters, continually transmutes, shifting back and forth from atonality, tonality, and polytonality. Formally, the work both opposes and espouses traditional paradigms; and it is this dichotomy, the tension created between old and new, which ultimately unifies the structure. Finally, the expansion of the role of the soloist, which entails not only the integration of multiple superimposed electronic layers but of the immersive diffusion of sound in multidimensional space, broadens the concerto form.
Connecting, Care and Agency: The Nature of Environmental Education at an Outdoor Education Centre
Keywords: environmental education
outdoor education

This thesis reports on a study designed to investigate the nature of environmental education (EE) at one well-established school board operated outdoor education centre called Faraway Dale located in Ontario, Canada. The specific research questions that guided the study were: (a) What are the structures that characterize environmental education for educators at the outdoor education centre? (b) What are the main understandings of environment and education that guide outdoor educators work with environmental education? (c) What are the tensions and contradictions of providing environmental education through an outdoor centre? The primary data sources for this study were the nine outdoor educators who work at the facility. A variety of data collecting strategies were used, over a period of five months, to re-present their experiences of providing EE. Analysis of the data revealed that the nature of EE at the outdoor centre is significantly different from what occurs in mainstream, indoor settings. The overall goal for environmental education at the outdoor centre is to foster a culture that leads to healthy people and healthy environments by encouraging a more equitable interplay among people and nature. This overall goal can be divided into three structures that characterize EE at the centre. These are: connecting people to the environment, encouraging a care-based relational orientation towards the environment, and building agency for living low consumption low impact lifestyles. The findings also confirm that the nature of EE which educators espouse and practice is directly linked to their understandings of the terms ‘environment’ and ‘education’. The major tensions and contradictions of providing EE in an outdoor context are also illuminated. The discussion focuses on the implications of the findings for theory, practice and research in EE and the work of outdoor educators in the field.
Improvisational Intelligence: A Study of the Cognitive Process of Improvisation
Keywords: improvisation music intelligence cognitive cognition

The teaching of music improvisation is commonly approached as the process of incorporating the vocabulary of a specific style. In the university setting this is most often accomplished through the methodology of jazz. As an alternative, improvisation is also taught as an experimental or experiential endeavor influenced by the practice of free-improvisation. A third model teaches improvisation as games; this is common in the field of Music Education. Although all these methods accomplish their various purposes, in their pedagogical application none of these models focus on the most distinctive feature of improvisation: how the musician thinks. Improvisation as a way of “thinking music” constitutes a form of musical intelligence that entails a number of cognitive processes that solve specific problems unique to the improvisational setting. As an alternative to the existing models, I propose to teach improvisation as a form of intelligence, with the purpose of empowering the learner to construct a spontaneous yet intended musical discourse meaningful to the improviser and representative of his or her own understanding of musical organization. In order to advance a pedagogical model based on improvisational intelligence, I have conducted a grounded theory research project to construct a theoretical model of the cognitive processes of improvisation deployed by professional improvisers, with the intention that this model inform the teaching of improvisational intelligence. The research comprised individual interviews with 10 improvisers. The participants improvised a piece of music and subsequently elaborated on the cognitive mechanisms deployed while improvising. The resulting theory from this research proposes that improvisational intelligence consists of residual and emergent behaviors mediated by a monitoring system. The theory is illustrated by three models, and it is summarized in six postulates. The practical application of the model does not form part of this research; turning the theoretical model into a practical teaching method constitutes a subsequent stage to the current work. Nonetheless, the discussion section of the thesis elaborates on possible pedagogical applications and challenges for the professional musician as well as for various institutional settings such as the elementary school, the secondary school, the university jazz program, and the classical performance program.
Effects of a Eucaloric Low Glycemic Index Diet on Insulin Sensitivity and Intramyocellular Lipid Content in Adults with Abdominal Obesity
Keywords: glycemic index
intramyocellular lipid IMCL
obesity
insulin sensitivity

Individuals with abdominal obesity are at higher risk for developing type 2 diabetes, predisposing cardiovascular events and insulin resistance. Low glycemic index (GI) diets may be beneficial in the management of insulin resistance. Insulin resistance is associated with increased intramyocellular lipid (IMCL) content as measured by proton nuclear magnetic resonance spectroscopy (1H-MRS). The primary objective of this thesis was to determine whether a low GI diet can improve insulin sensitivity by reducing IMCL of skeletal muscle. One hundred and twenty-one male and female participants aged 30 to 70 years (mean+SD, 53+10)) with abdominal obesity, entered a 4 to 6 week weight-maintaining, low-fat dietary advice run-in phase. Of the 121 eligible participants, 95 completed the run-in phase and were randomly assigned to either a low-GI (LGID, n=48) or high-GI diet (HGID, n=47) for 24 weeks. Participants underwent a 75g oral glucose tolerance test (OGTT) and had soleus-muscle IMCL measured by 1H-MRS at the beginning and end of the intervention period. Insulin sensitivity was assessed by the homeostatic model assessment index (HOMA) and the insulinogenic index (ISI) was calculated for insulin secretion. At the end of the run-in phase, there were significant reductions in serum total-, LDL-, and HDL-cholesterol (all, p<0.0001) and an increase in fasting plasma glucose (p<0.05). In 57 participants who wore a continuous glucose monitoring system for 24 hours during the run-in period, a total of 30% (p<0.001) of the variation in the incremental area under the blood glucose curve after self-selected breakfast meals was explained by GI. After 24 weeks, diet GI was significantly lower in the LGID than HGID group (55.5+3.1 vs 63.9+3.1, p<0.0001). Plasma glucose 60 minutes after the OGTT was significantly lower on the LGID than at baseline (p<0.05) and there was a non-significant trend towards an increase in ISI (p=0.07). On the HGID, ISI increased significantly from baseline (p<0.01). It is concluded that the LGID reduced 60 minute plasma glucose but did not significantly affect IMCL or insulin sensitivity in individuals with abdominal obesity.
Identity and Wisdom of Young Adults in Canada and Pakistan with Asperger Syndrome: A Cross-cultural Study
Keywords: Developmental psychology
Personality

This cross-cultural study investigates identity and wisdom in people with Asperger syndrome (AS). The diagnostic characteristics of Asperger syndrome are universal, as they are manifest in particular outward behaviours (DSM-4). One of the aims of this study is to explore whether or not identity and wisdom are also universal in people with AS. Interviews were conducted that asked participants about their own lives, as well as about the acquaintances and historical figures to whom they look to for wisdom. Some self-report measures of identity, values, wisdom, and well-being were also administered to the participants. Forty-six male participants (half diagnosed with Asperger syndrome) were recruited from Karachi, Pakistan, and the Greater Toronto Area (GTA), Canada. People with AS were matched with non-autistics according to age. The results of this study showed that the Canadian Asperger group was significantly higher in social identity, and lower in personal integrity, as compared to the Pakistani Asperger group. The value of conservation was significantly higher in the Asperger groups than in the control groups. Mean scores on the 3-dimensional wisdom scale differed significantly between the Asperger and control groups, but remained the same between the two Asperger groups. People with AS were equally satisfied with their lives as compared to non-autistics. There was a greater emphasis on the theme of communion for the Pakistani Asperger group than for the Canadian Asperger group. Results also found a greater emphasis on the theme of personal agency in both the Asperger groups, as compared to the control groups. The Pakistani Asperger group mainly considered religious figures to be the wisest in history, whereas the Canadian Asperger group primarily nominated scientists as the wisest figures in history. Both the Asperger groups considered family members to be the wisest among their acquaintances. The concept of wisdom centered on the theme of cognition for both Asperger groups. The study was limited to male participants only, and future research should study both genders.
Regulation of Fas-deficient Lymphoproliferative Double Negative T Cells by Interferon Gamma and the Fc Receptor Gamma Chain
Keywords: Fas
Interferon gamma
Fc receptor common gamma chain
Autoimmune lymphoproliferative syndrome
Graft-versus-host disease
Regulatory T cells
Double negative T cells

The Fas pathway is critical for the maintenance of normal T cell homeostasis. Humans and mice with defects in this pathway exhibit the accumulation of large numbers of peripheral lymphocytes and lupus-like autoimmunity. A major feature of these organisms is the accumulation of non-NK TCRαβ+CD4-CD8- “double negative” (DN) T cells. While regulatory T cells (Tregs) with the DN phenotype have been extensively characterized in Fas-sufficient mice and humans, limited data exist on the role of DN T cells as Tregs in Fas-deficient animals. In fact, most of the literature suggests that the DN T cells accumulating in Fas-deficiency states are pathogenic, contributing to secondary lymph node enlargement and autoimmune disease. In this body of work, data are presented that illustrate that Fas-deficient lymphoproliferative (LPR) DN T cells can act as Tregs in an interferon γ (IFNγ)- and Fas ligand (FasL)-dependent fashion toward Fas-sufficient T cells. LPR DN T cells needed to be able to secrete and respond to IFNγ in order to upregulate surface FasL, in order to ameliorate GVHD mediated by CD4+ T cells in vivo and to suppress the proliferation of and kill activated CD4+ T cells in vitro. FcRγ, a key molecule involved in innate immune responses, can substitute for CD3ζ in the T cell receptor (TCR) of mouse and human T cells in certain circumstances; in doing so, it is essential for the regulatory function of TCR transgenic DN Tregs. FcRγ-deficient LPR mice were found to have exacerbated T cell accumulation and early mortality. We show that while FcRγ expression was required for LPR DN T cells to regulate CD4+ and CD8+ T cells responding to alloantigens in vitro and in vivo, it does not control autologous lymphoproliferation in LPR mice by supporting the function of a regulatory cell, nor does it affect the rate of proliferation of LPR T cells in vivo. Instead, FcRγ-expressing LPR CD4+, CD8+ and DN T cells were found to be undergoing apoptosis at a high rate in vivo, and in contrast to their FcRγ-deficient counterparts, FcRγ+ LPR DN T cells were capable of undergoing TCR restimulation-induced cell death (RICD). The data presented in this thesis therefore show that LPR DN T cells can exhibit IFNγ-, FasL- and FcRγ-dependent regulatory function, and also illustrate a previously unknown function for FcRγ in controlling the expansion of Fas-deficient T cells. The implications of these data for autoimmune lymphoproliferative syndromes, and normal T cell homeostasis, are discussed.