Seftriakson. Seftriakson (6R-6alfa, 7beta(Z)-7-2-amino-4-tiazolil(metoksiimino)asetilamino-8-okso-3-(1,2,5,6-tetrahidro-2-metil-5,6) -diokso-1,2,4-triazin-3-il)tiometil-5-tia-1-azabitsiklo 4.2.0 okt-2-en-2-karboksilik kislota (dinatriy tuzi shaklida)) - keng spektrga ega sefalosporin qatoriga kiruvchi antibiotik. Farmakologik ta'sir. Parenteral yuborish yuborish uchun ishlatiladigan, keng spektrga ega III avlodsefalosporin antibiotik. Bakteritsid aktivligi обусловлена подавлением синтеза bakteriya hujayra devori sinteziini buzishga (murein sintezini buzadi) asoslanadi. Grammanfiy va grammusbat mikroorganizmlarning ko'pchilik бbeta-laktamazalariga chidamliligi bila ajralib turadi. Quyidagi mikroorganizmlarga nisbata aktiv: grammusbat aeroblar — "Staphylococcus aureus" (jumladanpenitsillinaza ishlab chiqaruvchi shtammlarga ham), "Staphylococcus epidermidis", "Streptococcus pneumoniae", "Streptococcus pyogenes", "Streptococcus viridans"; grammanfiy aeroblar: "Acinetobacter calcoaceticus", "Enterobacter aerogenes", "Enterobacter cloacae," "Escherichia coli," "Haemophilus influenzae" (jumladan penitsillinaza ishlab chiqaruvchi shtammlar), "Haemophilus parainfluenzae", "Klebsiella spp." (jumladan "Klebsiella pneumoniae"), "Moraxella catarrhalis", (jumladan penitsillinaza ishlab chiqaruvchi shtammlar), "Morganella morganii", "Neisseria gonorrhoeae" (jumladan penitsillinaza ishlab chiqaruvchi shtammlar), "Neisseria meningitidis," "Proteus mirabilis"," Proteus vulgaris," "Serratia spp." (jumladan "Serratia marcescens"); "Pseudomonas aeruginosa" ning alohida shtammlari ham sezgir hisoblanadi; anaeroblar: "Bacteroides fragilis", "Clostridium spp." ("Clostridium difficiledan tashqari"), "Peptostreptococcus spp". "in vitro" sharoitda quyidagi mikroorganizmlarning ko'pchilik shtammlariga nisbatan aktvilikka ega, buning klinik ahamiyati ma'lum bo'lmasa ham: "Citrobacter diversus, Citrobacter freundii, Providencia spp.," "Providencia rettgeri, Salmonella spp.," (jumladan"Salmonella typhi"), "Shigella spp".; "Streptococcus agalactiae, Bacteroides bivius, Bacteroides melaninogenicus." Metitsillinga chidamli stafilokokklar sefalosporilarga chidamlidir, jumladan seftriaksonga ham; D guruh streptokokklarning ko'pchilik shtammari va enterokokklar, jumladan "Enterococcus faecalis" ham seftriaksonga nisbatan chidamli hisoblanadi.