gene_name	Entrez_Gene_Id	Center	NCBI_Build	Chromosome	Start_Position	End_Position	Strand	Reference_Allele	Tumor_Seq_Allele1	Tumor_Seq_Allele2	Variant_Classification	Variant_Type	tx	exon	txChange	aaChange	Func.refGene	Gene.refGene	GeneDetail.refGene	ExonicFunc.refGene	AAChange.refGene	cytoBand	Tumor_Sample_Barcode	ExAC_ALL	ExAC_AFR	ExAC_AMR	ExAC_EAS	ExAC_FIN	ExAC_NFE	ExAC_OTH	ExAC_SAS	avsnp150	DamagePredCount	SIFT_pred	SIFT4G_pred	Polyphen2_HDIV_pred	Polyphen2_HVAR_pred	LRT_pred	MutationTaster_pred	MutationAssessor_pred	FATHMM_pred	PROVEAN_pred	VEST4_score	MetaSVM_pred	MetaLR_pred	M-CAP_pred	REVEL_score	MutPred_score	MVP_score	MPC_score	PrimateAI_pred	DEOGEN2_pred	BayesDel_addAF_pred	BayesDel_noAF_pred	ClinPred_pred	LIST-S2_pred	CADD_raw	CADD_phred	DANN_score	fathmm-MKL_coding_pred	fathmm-XF_coding_pred	Eigen-raw_coding	Eigen-phred_coding	Eigen-PC-raw_coding	Eigen-PC-phred_coding	GenoCanyon_score	integrated_fitCons_score	GM12878_fitCons_score	H1-hESC_fitCons_score	HUVEC_fitCons_score	LINSIGHT	GERP++_NR	GERP++_RS	phyloP100way_vertebrate	phyloP30way_mammalian	phyloP17way_primate	phastCons100way_vertebrate	phastCons30way_mammalian	phastCons17way_primate	bStatistic	Interpro_domain	GTEx_V8_gene	GTEx_V8_tissue	cosmic92Coding	Hugo_Symbol	n_ref_count	n_alt_count	t_ref_count	t_alt_count	TumorVAF	getz	washu
ENSG00000117713.20	.	BCM	GRCh38.p13	chr1	26774772	26774772	+	C	C	-	Frame_Shift_Del	NA	ENST00000324856.13	exon18	c.4545delC	p.S1516Lfs*11	exonic	ENSG00000117713.20	.	frameshift deletion	ENSG00000117713.20:ENST00000324856.13:exon18:c.4545delC:p.S1516Lfs*11	1p36.11	C3N-01388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARID1A	191	1	415	27	0.0610859728506787	NA	TRUE
ENSG00000185104.20	.	BCM	GRCh38.p13	chr1	50567164	50567164	+	A	A	G	Missense_Mutation	SNP	ENST00000396153.7	exon13	c.T1181C	p.M394T	exonic	ENSG00000185104.20	.	nonsynonymous SNV	ENSG00000185104.20:ENST00000396153.7:exon13:c.T1181C:p.M394T	1p32.3	C3N-01388	.	.	.	.	.	.	.	.	.	13.20	D	T	P	P	D	D	L	T	D	0.917	T	T	D	0.435	0.478	0.886	0.731	D	D	D	D	D	D	3.032	23.500	0.989	D	D	0.252	3.540	0.422	4.516	1.000	0.732	0.744	0.710	0.613	.	5.870	5.870	8.867	1.312	0.756	1.000	1.000	1.000	527	UAS	.	.	.	FAF1	83	0	250	15	0.0566037735849057	TRUE	TRUE
ENSG00000159409.15	.	BCM	GRCh38.p13	chr1	151709009	151709009	+	G	G	A	Missense_Mutation	SNP	ENST00000290583.9	exon5	c.C475T	p.R159W	exonic	ENSG00000159409.15	.	nonsynonymous SNV	ENSG00000159409.15:ENST00000290583.9:exon5:c.C475T:p.R159W	1q21.3	C3N-01388	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.634	T	T	D	0.340	0.491	0.218	2.609	D	T	T	T	D	D	4.840	33	0.998	D	D	0.262	3.591	0.248	3.428	1.000	0.554	0.574	0.602	0.542	.	4.080	3.150	9.584	0.206	-0.161	1.000	0.999	0.989	324	RNA_recognition_motif_domain	.	.	.	CELF3	119	0	276	29	0.0950819672131148	TRUE	TRUE
ENSG00000158715.6	.	BCM	GRCh38.p13	chr1	205663445	205663445	+	C	C	A	Missense_Mutation	SNP	ENST00000367145.4	exon3	c.G346T	p.D116Y	exonic	ENSG00000158715.6	.	nonsynonymous SNV	ENSG00000158715.6:ENST00000367145.4:exon3:c.G346T:p.D116Y	1q32.1	C3N-01388	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	N	N	L	D	N	0.369	D	D	D	0.387	0.481	0.542	0.464	T	T	D	D	T	T	1.802	17.750	0.972	D	N	-0.524	1.130	-0.406	1.361	1.000	0.696	0.588	0.723	0.662	.	5.500	4.560	0.136	1.026	0.599	0.001	0.966	0.997	681	.	.	.	.	SLC45A3	220	0	497	114	0.18657937806874	TRUE	TRUE
ENSG00000163755.9	.	BCM	GRCh38.p13	chr3	149172181	149172181	+	C	C	T	Missense_Mutation	SNP	ENST00000296051.7	exon17	c.C2974T	p.P992S	exonic	ENSG00000163755.9	.	nonsynonymous SNV	ENSG00000163755.9:ENST00000296051.7:exon17:c.C2974T:p.P992S	3q24	C3N-01388	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.845	D	D	D	0.619	0.716	0.938	0.591	T	D	D	D	D	D	3.797	25.800	0.999	D	D	0.846	9.756	0.849	11.742	1.000	0.707	0.725	0.725	0.714	.	6.060	6.060	6.554	1.026	0.594	1.000	0.995	0.995	921	Hermansky-Pudlak_syndrome_3_protein,_C-terminal_domain	.	.	ID=COSV99224248;OCCURENCE=1(ovary)	HPS3	175	0	277	24	0.079734219269103	TRUE	TRUE
ENSG00000090402.8	.	BCM	GRCh38.p13	chr3	165032682	165032682	+	T	T	C	Missense_Mutation	SNP	ENST00000264382.8	exon24	c.A2576G	p.D859G	exonic	ENSG00000090402.8	.	nonsynonymous SNV	ENSG00000090402.8:ENST00000264382.8:exon24:c.A2576G:p.D859G	3q26.1	C3N-01388	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	L	D	D	0.206	T	T	D	0.158	0.480	0.750	0.033	T	T	T	T	T	T	0.724	8.677	0.659	N	N	-1.012	0.391	-1.038	0.444	0.000	0.487	0.574	0.574	0.646	.	4.780	0.858	0.014	0.098	0.665	0.000	0.002	0.118	856	.	.	.	.	SI	103	0	234	20	0.078740157480315	TRUE	TRUE
ENSG00000215218.4	.	BCM	GRCh38.p13	chr5	6491221	6491221	+	C	C	T	Missense_Mutation	SNP	ENST00000399816.4	exon2	c.C358T	p.R120W	exonic	ENSG00000215218.4	.	nonsynonymous SNV	ENSG00000215218.4:ENST00000399816.4:exon2:c.C358T:p.R120W	5p15.31	C3N-01388	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	U	D	M	.	D	0.836	D	D	D	0.815	0.659	0.334	.	D	T	D	D	D	D	4.280	29.400	0.999	D	D	0.817	9.127	0.744	8.668	1.000	0.583	0.588	0.615	0.586	.	5.030	5.030	5.543	1.026	0.599	1.000	0.995	0.968	976	.	.	.	ID=COSV101297099;OCCURENCE=2(endometrium)	UBE2QL1	71	0	141	10	0.0662251655629139	TRUE	TRUE
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	170008597	170008597	+	A	A	C	Missense_Mutation	SNP	ENST00000520908.7	exon31	c.A3173C	p.K1058T	exonic	ENSG00000134516.18	.	nonsynonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon31:c.A3173C:p.K1058T	5q35.1	C3N-01388	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	D	D	M	T	D	0.830	T	T	T	0.532	0.434	0.829	1.479	T	T	D	D	D	D	4.700	32	0.995	D	D	0.672	6.747	0.694	7.646	1.000	0.707	0.725	0.653	0.530	.	5.710	5.710	9.325	1.312	0.756	1.000	1.000	1.000	954	.	.	.	ID=COSV56971995;OCCURENCE=2(large_intestine),1(stomach)	DOCK2	230	0	519	47	0.0830388692579505	TRUE	TRUE
ENSG00000112195.9	.	BCM	GRCh38.p13	chr6	41198141	41198141	+	G	G	A	Missense_Mutation	SNP	ENST00000483722.2	exon2	c.C344T	p.P115L	exonic	ENSG00000112195.9	.	nonsynonymous SNV	ENSG00000112195.9:ENST00000483722.2:exon2:c.C344T:p.P115L	6p21.1	C3N-01388	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	D	0.607	T	T	D	0.245	0.500	0.628	0.809	T	T	T	T	D	T	3.290	24.100	0.998	D	N	0.500	5.037	0.418	4.485	1.000	0.707	0.725	0.602	0.542	.	4.680	4.680	3.175	1.176	0.676	0.997	0.092	0.361	906	.	.	.	ID=COSV72439213;OCCURENCE=1(central_nervous_system),1(skin)	TREML2	70	0	157	10	0.0598802395209581	NA	TRUE
ENSG00000164663.14	.	BCM	GRCh38.p13	chr6	41798806	41798806	+	A	A	C	Nonsense_Mutation	SNP	ENST00000394253.7	exon6	c.T1794G	p.Y598X	exonic	ENSG00000164663.14	.	stopgain	ENSG00000164663.14:ENST00000394253.7:exon6:c.T1794G:p.Y598X	6p21.1	C3N-01388	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.519	.	.	.	.	.	.	.	.	.	D	D	.	.	7.536	38	0.996	D	N	0.864	10.165	0.768	9.250	1.000	0.707	0.654	0.725	0.492	.	6.170	6.170	3.951	1.312	0.756	1.000	1.000	1.000	476	Ubiquitin_specific_protease_domain;Peptidase_C19,_ubiquitin_carboxyl-terminal_hydrolase;Ubiquitin_specific_protease,_conserved_site	.	.	.	USP49	466	1	889	67	0.0700836820083682	TRUE	TRUE
ENSG00000168830.8	.	BCM	GRCh38.p13	chr6	87015945	87015945	+	G	G	A	Missense_Mutation	SNP	ENST00000305344.7	exon2	c.G611A	p.R204Q	exonic	ENSG00000168830.8	.	nonsynonymous SNV	ENSG00000168830.8:ENST00000305344.7:exon2:c.G611A:p.R204Q	6q14.3	C3N-01388	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	U	D	M	T	N	0.521	T	T	T	0.326	.	0.802	1.400	T	T	T	T	D	D	3.893	26.300	0.999	D	D	0.595	5.870	0.573	5.900	0.026	0.487	0.574	0.574	0.564	.	4.510	4.510	7.078	0.913	0.485	1.000	0.997	0.986	809	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV59508189;OCCURENCE=1(breast),1(large_intestine),1(skin)	HTR1E	100	0	233	23	0.08984375	TRUE	TRUE
ENSG00000120549.18	.	BCM	GRCh38.p13	chr10	24524535	24524535	+	C	C	A	Missense_Mutation	SNP	ENST00000376454.8	exon13	c.C2669A	p.S890Y	exonic	ENSG00000120549.18	.	nonsynonymous SNV	ENSG00000120549.18:ENST00000376454.8:exon13:c.C2669A:p.S890Y	10p12.1	C3N-01388	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.526	T	T	D	0.298	0.353	0.746	0.604	T	D	D	T	D	D	3.186	23.800	0.994	D	D	0.584	5.767	0.519	5.337	1.000	0.693	0.659	0.644	0.668	.	5.420	5.420	7.369	0.999	0.548	1.000	0.512	0.403	933	.	.	.	.	KIAA1217	338	0	677	63	0.0851351351351351	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-01388	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	275	0	602	50	0.0766871165644172	TRUE	TRUE
ENSG00000048471.14	.	BCM	GRCh38.p13	chr16	12278019	12278019	+	G	G	A	Missense_Mutation	SNP	ENST00000566228.6	exon15	c.G1765A	p.E589K	exonic	ENSG00000048471.14	.	nonsynonymous SNV	ENSG00000048471.14:ENST00000566228.6:exon15:c.G1765A:p.E589K	16p13.13	C3N-01388	.	.	.	.	.	.	.	.	.	10.18	D	T	.	.	D	N	M	T	D	0.764	T	T	D	0.156	.	0.570	.	T	T	D	D	D	D	3.414	24.400	0.999	D	N	0.190	3.259	0.199	3.179	0.985	0.707	0.725	0.602	0.655	.	5.460	5.460	5.404	1.176	0.676	1.000	0.831	0.616	933	.	.	.	.	SNX29	238	0	493	41	0.0767790262172285	TRUE	NA
ENSG00000181284.3	.	BCM	GRCh38.p13	chr17	7436910	7436910	+	C	C	T	Missense_Mutation	SNP	ENST00000323206.2	exon3	c.C931T	p.R311C	exonic	ENSG00000181284.3	.	nonsynonymous SNV	ENSG00000181284.3:ENST00000323206.2:exon3:c.C931T:p.R311C	17p13.1	C3N-01388	.	.	.	.	.	.	.	.	.	8.19	D	D	D	D	N	D	L	T	N	0.208	T	T	D	0.121	0.459	0.355	.	T	T	T	T	D	.	3.819	25.900	0.999	D	N	0.295	3.753	0.265	3.522	1.000	0.726	0.594	0.522	0.373	.	4.470	4.470	0.884	1.026	0.599	0.988	0.558	0.305	301	Mab-21_domain	.	.	.	TMEM102	193	0	299	25	0.0771604938271605	TRUE	TRUE
ENSG00000130701.4	.	BCM	GRCh38.p13	chr20	62415591	62415591	+	C	C	T	Missense_Mutation	SNP	ENST00000252998.2	exon8	c.G614A	p.R205Q	exonic	ENSG00000130701.4	.	nonsynonymous SNV	ENSG00000130701.4:ENST00000252998.2:exon8:c.G614A:p.R205Q	20q13.33	C3N-01388	1.681e-05	0	8.663e-05	0	0	1.541e-05	0	0	rs757950710	3.20	D	T	D	P	N	N	L	T	N	0.196	T	T	T	0.107	.	0.201	0.289	T	T	T	T	D	T	2.673	22.800	0.998	N	N	-0.373	1.442	-0.536	1.144	0.932	0.515	0.547	0.604	0.563	.	4.240	3.290	0.557	1.022	0.596	0.429	0.082	0.075	819	.	.	.	.	RBBP8NL	203	0	508	45	0.081374321880651	TRUE	NA
ENSG00000068354.16	.	BCM	GRCh38.p13	chrX	48560539	48560539	+	T	T	C	Missense_Mutation	SNP	ENST00000376771.9	exon6	c.T1631C	p.L544S	exonic	ENSG00000068354.16	.	nonsynonymous SNV	ENSG00000068354.16:ENST00000376771.9:exon6:c.T1631C:p.L544S	Xp11.23	C3N-01388	.	.	.	.	.	.	.	.	.	3.19	T	D	P	B	N	D	L	T	N	0.326	T	T	T	0.052	0.183	0.189	1.720	T	T	T	T	T	T	1.379	14.940	0.984	D	.	.	.	.	.	0.887	.	.	.	.	.	4.940	4.940	2.588	0.207	-0.113	1.000	0.051	0.021	178	.	.	.	.	TBC1D25	91	0	218	14	0.0603448275862069	TRUE	TRUE
ENSG00000131263.13	.	BCM	GRCh38.p13	chrX	74591787	74591787	+	G	G	A	Nonsense_Mutation	SNP	ENST00000332687.11	exon4	c.C1528T	p.R510X	exonic	ENSG00000131263.13	.	stopgain	ENSG00000131263.13:ENST00000332687.11:exon4:c.C1528T:p.R510X	Xq13.2	C3N-01388	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	N	D	.	.	.	0.867	.	.	.	.	.	.	.	.	.	D	D	.	.	5.638	34	0.997	D	.	.	.	.	.	0.989	.	.	.	.	.	5.410	4.520	1.114	-0.191	-0.676	0.999	0.992	0.537	99	.	.	.	.	RLIM	219	0	371	53	0.125	NA	TRUE
ENSG00000268089.3	.	BCM	GRCh38.p13	chrX	152649294	152649294	+	C	C	T	Missense_Mutation	SNP	ENST00000598523.3	exon5	c.C571T	p.P191S	exonic	ENSG00000268089.3	.	nonsynonymous SNV	ENSG00000268089.3:ENST00000598523.3:exon5:c.C571T:p.P191S	Xq28	C3N-01388	.	.	.	.	.	.	.	.	.	11.12	.	D	.	.	D	D	.	D	.	0.946	D	D	D	0.980	0.914	0.949	.	T	.	D	D	D	.	3.283	24.100	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.800	5.800	7.905	1.026	0.599	1.000	0.996	0.988	620	.	.	.	ID=COSV100941094;OCCURENCE=1(skin)	GABRQ	237	0	423	37	0.0804347826086956	TRUE	TRUE
ENSG00000163377.16	.	BCM	GRCh38.p13	chr3	68752972	68752972	+	G	G	A	Silent	SNP	ENST00000295569.12	exon4	c.C177T	p.H59H	exonic	ENSG00000163377.16	.	synonymous SNV	ENSG00000163377.16:ENST00000295569.12:exon4:c.C177T:p.H59H	3p14.1	C3N-01388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TAFA4	329	0	448	39	0.080082135523614	TRUE	TRUE
ENSG00000112787.13	.	BCM	GRCh38.p13	chr12	132583130	132583130	+	C	C	T	Silent	SNP	ENST00000434748.2	exon17	c.C2490T	p.S830S	exonic	ENSG00000112787.13	.	synonymous SNV	ENSG00000112787.13:ENST00000434748.2:exon17:c.C2490T:p.S830S	12q24.33	C3N-01388	0.0002	0	0	0	.	0	0	0.0003	rs780304489	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBRSL1	124	0	185	24	0.114832535885167	TRUE	NA
ENSG00000069966.18	.	BCM	GRCh38.p13	chr15	52124557	52124557	+	A	A	G	Silent	SNP	ENST00000261837.11	exon12	c.T1092C	p.F364F	exonic	ENSG00000069966.18	.	synonymous SNV	ENSG00000069966.18:ENST00000261837.11:exon12:c.T1092C:p.F364F	15q21.2	C3N-01388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GNB5	229	0	388	36	0.0849056603773585	TRUE	TRUE
ENSG00000261713.6	.	BCM	GRCh38.p13	chr16	1066375	1066375	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000261713.6;ENSG00000261720.1	.	.	.	16p13.3	C3N-01388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SSTR5-AS1	128	0	209	22	0.0952380952380952	TRUE	NA
ENSG00000102024.18	.	BCM	GRCh38.p13	chrX	115640110	115640110	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000102024.18	.	.	.	Xq23	C3N-01388	.	.	.	.	.	.	.	.	.	8.11	.	D	.	.	.	D	.	.	.	0.598	D	D	D	0.345	0.441	0.772	.	.	T	D	T	D	T	3.171	23.800	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.790	5.790	5.419	1.026	0.599	1.000	1.000	0.998	889	Calponin_homology_domain	.	.	.	PLS3	66	1	157	10	0.0598802395209581	TRUE	TRUE
ENSG00000081248.11	.	BCM	GRCh38.p13	chr1	201087897	201087897	+	C	C	A	Missense_Mutation	SNP	ENST00000362061.4	exon7	c.G933T	p.W311C	exonic	ENSG00000081248.11	.	nonsynonymous SNV	ENSG00000081248.11:ENST00000362061.4:exon7:c.G933T:p.W311C	1q32.1	C3L-03388	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.925	D	D	D	0.873	0.677	0.960	0.642	D	D	D	D	D	D	4.723	32	0.973	D	D	0.847	9.779	0.768	9.254	1.000	0.447	0.563	0.547	0.530	.	4.820	4.820	5.926	1.026	0.599	1.000	1.000	1.000	917	Ion_transport_domain	.	.	.	CACNA1S	457	0	473	239	0.335674157303371	TRUE	TRUE
ENSG00000143951.16	.	BCM	GRCh38.p13	chr2	63433844	63433844	+	C	C	A	Missense_Mutation	SNP	ENST00000272321.12	exon9	c.G726T	p.W242C	exonic	ENSG00000143951.16	.	nonsynonymous SNV	ENSG00000143951.16:ENST00000272321.12:exon9:c.G726T:p.W242C	2p15	C3L-03388	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.943	T	T	D	0.558	0.801	0.831	0.689	T	T	D	D	D	D	4.002	27.000	0.990	D	D	0.791	8.599	0.760	9.045	0.999	0.615	0.588	0.659	0.655	.	5.430	5.430	5.851	1.026	0.599	1.000	1.000	0.996	481	.	.	.	.	WDPCP	166	0	155	24	0.134078212290503	TRUE	TRUE
ENSG00000168038.11	.	BCM	GRCh38.p13	chr3	41800256	41800256	+	A	A	G	Missense_Mutation	SNP	ENST00000301831.9	exon20	c.T1886C	p.I629T	exonic	ENSG00000168038.11	.	nonsynonymous SNV	ENSG00000168038.11:ENST00000301831.9:exon20:c.T1886C:p.I629T	3p22.1	C3L-03388	.	.	.	.	.	.	.	.	rs980545512	13.20	D	D	D	P	U	D	M	T	D	0.774	T	T	D	0.573	0.586	0.699	0.194	T	T	D	D	D	D	3.744	25.600	0.998	D	D	0.563	5.565	0.517	5.320	1.000	0.615	0.588	0.602	0.655	.	5.320	5.320	8.589	1.312	0.756	0.993	1.000	0.996	690	.	.	.	.	ULK4	212	0	224	39	0.14828897338403	TRUE	NA
ENSG00000196578.4	.	BCM	GRCh38.p13	chr3	98087309	98087309	+	G	G	A	Missense_Mutation	SNP	ENST00000358642.2	exon1	c.G137A	p.G46E	exonic	ENSG00000196578.4	.	nonsynonymous SNV	ENSG00000196578.4:ENST00000358642.2:exon1:c.G137A:p.G46E	3q11.2	C3L-03388	.	.	.	.	.	.	.	.	.	7.20	D	D	D	D	U	N	M	T	D	0.482	T	T	T	0.078	0.597	0.518	0.067	T	T	T	T	D	T	2.172	20.700	0.997	N	N	0.364	4.130	0.195	3.161	0.001	0.487	0.574	0.547	0.564	.	5.200	4.320	0.037	0.111	0.600	0.000	0.004	0.005	758	GPCR,_rhodopsin-like,_7TM	.	.	.	OR5AC2	268	0	280	17	0.0572390572390572	TRUE	TRUE
ENSG00000172497.9	.	BCM	GRCh38.p13	chr5	81371793	81371793	+	G	G	A	Missense_Mutation	SNP	ENST00000307624.8	exon3	c.C215T	p.T72I	exonic	ENSG00000172497.9	.	nonsynonymous SNV	ENSG00000172497.9:ENST00000307624.8:exon3:c.C215T:p.T72I	5q14.1	C3L-03388	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	D	0.311	T	T	T	0.122	0.611	0.176	0.107	T	T	T	T	T	T	2.767	23.000	0.948	N	N	-0.291	1.636	-0.136	1.949	1.000	0.554	0.574	0.618	0.542	.	5.800	3.810	0.820	1.176	0.676	1.000	1.000	0.981	647	Hotdog_acyl-CoA_thioesterase_(ACOT)-type_domain;Thioesterase_domain	.	.	.	ACOT12	333	0	366	55	0.130641330166271	TRUE	TRUE
ENSG00000124721.18	.	BCM	GRCh38.p13	chr6	38783040	38783040	+	G	G	A	Missense_Mutation	SNP	ENST00000359357.7	exon15	c.G1645A	p.A549T	exonic	ENSG00000124721.18	.	nonsynonymous SNV	ENSG00000124721.18:ENST00000359357.7:exon15:c.G1645A:p.A549T	6p21.2	C3L-03388	.	.	.	.	.	.	.	.	.	3.19	T	.	B	B	N	D	L	T	N	0.420	T	T	T	0.083	0.304	0.542	0.119	T	T	T	T	D	T	2.302	21.600	0.991	D	N	-0.341	1.517	-0.125	1.977	1.000	0.428	0.547	0.547	0.613	.	5.830	4.020	2.631	0.184	0.676	1.000	0.994	0.980	595	Dynein_heavy_chain,_domain-1	.	.	ID=COSV59426631;OCCURENCE=1(endometrium)	DNAH8	250	0	289	46	0.137313432835821	TRUE	TRUE
ENSG00000112249.14	.	BCM	GRCh38.p13	chr6	100725687	100725687	+	G	G	A	Missense_Mutation	SNP	ENST00000369162.7	exon11	c.C1754T	p.P585L	exonic	ENSG00000112249.14	.	nonsynonymous SNV	ENSG00000112249.14:ENST00000369162.7:exon11:c.C1754T:p.P585L	6q16.3	C3L-03388	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.955	D	T	D	0.720	0.805	0.667	0.801	D	T	D	D	D	D	4.474	32	0.998	D	D	1.091	17.129	0.980	17.662	1.000	0.706	0.725	0.710	0.613	.	5.230	5.230	9.597	1.176	0.618	1.000	0.990	0.950	778	AAA+_ATPase_domain;Helicase_superfamily_1/2,_ATP-binding_domain;DEAD/DEAH_box_helicase_domain	.	.	.	ASCC3	313	0	347	37	0.0963541666666667	TRUE	TRUE
ENSG00000170835.16	.	BCM	GRCh38.p13	chr9	133071603	133071603	+	C	C	G	Missense_Mutation	SNP	ENST00000372080.8	exon11	c.C2101G	p.P701A	exonic	ENSG00000170835.16	.	nonsynonymous SNV	ENSG00000170835.16:ENST00000372080.8:exon11:c.C2101G:p.P701A	9q34.13	C3L-03388	.	.	.	.	.	.	.	.	.	1.16	T	T	.	.	.	N	.	T	N	0.208	T	T	D	0.072	.	0.161	0.237	T	T	T	T	T	T	-0.837	0.021	0.389	N	N	-1.838	0.020	-1.922	0.020	0.199	0.403	0.547	0.578	0.563	.	1.630	-2.580	-0.427	-4.124	-0.782	0.000	0.000	0.002	962	Mucin-like_domain	.	.	ID=COSV60828254;OCCURENCE=1(pancreas)	CEL	224	1	203	37	0.154166666666667	NA	TRUE
ENSG00000151208.17	.	BCM	GRCh38.p13	chr10	77829361	77829361	+	G	G	A	Nonsense_Mutation	SNP	ENST00000372391.7	exon12	c.C2179T	p.Q727X	exonic	ENSG00000151208.17	.	stopgain	ENSG00000151208.17:ENST00000372391.7:exon12:c.C2179T:p.Q727X	10q22.3	C3L-03388	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.849	.	.	.	.	.	.	.	.	.	D	D	.	.	8.386	42	0.998	D	N	1.002	13.995	0.884	13.085	1.000	0.732	0.546	0.744	0.714	.	5.290	5.290	9.602	1.176	0.676	1.000	1.000	0.972	628	PDZ_domain	.	.	.	DLG5	434	0	490	73	0.129662522202487	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3L-03388	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	373	0	915	80	0.0804020100502513	TRUE	TRUE
ENSG00000102452.17	.	BCM	GRCh38.p13	chr13	101395197	101395197	+	G	G	A	Missense_Mutation	SNP	ENST00000251127.11	exon3	c.C277T	p.R93W	exonic	ENSG00000102452.17	.	nonsynonymous SNV	ENSG00000102452.17:ENST00000251127.11:exon3:c.C277T:p.R93W	13q33.1	C3L-03388	8.335e-06	0	0	0	0	1.51e-05	0	0	rs778761293	19.20	D	D	D	D	D	D	L	D	D	0.875	D	D	D	0.929	0.703	0.776	2.027	D	D	D	D	D	D	4.424	31	0.999	D	D	0.760	8.041	0.742	8.609	1.000	0.706	0.590	0.618	0.613	.	5.750	5.750	3.988	1.176	0.676	1.000	0.893	0.979	946	Ion_transport_domain	.	.	ID=COSV51932802;OCCURENCE=1(oesophagus),3(large_intestine),1(central_nervous_system),1(skin)	NALCN	105	0	91	23	0.201754385964912	TRUE	TRUE
ENSG00000140400.17	.	BCM	GRCh38.p13	chr15	75359689	75359689	+	C	C	T	Missense_Mutation	SNP	ENST00000267978.10	exon16	c.G1879A	p.V627I	exonic	ENSG00000140400.17	.	nonsynonymous SNV	ENSG00000140400.17:ENST00000267978.10:exon16:c.G1879A:p.V627I	15q24.2	C3L-03388	1.659e-05	0	0	0	0	3.019e-05	0	0	rs748277033	1.20	T	T	B	B	N	N	N	T	N	0.166	T	T	D	0.238	0.530	0.217	0.066	T	T	T	T	T	T	0.591	7.428	0.776	N	N	-0.949	0.460	-0.853	0.685	1.000	0.672	0.698	0.644	0.711	.	5.050	1.850	0.312	-0.214	-0.173	0.078	0.941	0.600	518	Glycosyl_hydrolase_family_38,_C-terminal	.	.	ID=COSV51228106;OCCURENCE=1(large_intestine),1(bone)	MAN2C1	293	0	300	71	0.191374663072776	TRUE	TRUE
ENSG00000158865.12	.	BCM	GRCh38.p13	chr16	24875709	24875709	+	T	T	C	Missense_Mutation	SNP	ENST00000347898.7	exon6	c.T455C	p.I152T	exonic	ENSG00000158865.12	.	nonsynonymous SNV	ENSG00000158865.12:ENST00000347898.7:exon6:c.T455C:p.I152T	16p12.1	C3L-03388	8.589e-06	0	0	0	0	1.541e-05	0	0	rs761238809	15.20	D	D	B	B	N	D	M	D	D	0.855	D	D	D	0.723	0.625	0.753	0.221	T	T	D	D	D	D	3.082	23.600	0.991	D	D	0.127	2.993	0.199	3.176	0.636	0.487	0.574	0.547	0.564	.	4.370	4.370	7.411	1.131	0.656	1.000	0.992	0.787	819	.	.	.	.	SLC5A11	218	0	264	58	0.180124223602484	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7670700	7670700	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon10	c.C1009T	p.R337C	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon10:c.C1009T:p.R337C	17p13.1	C3L-03388	8.521e-06	0.0001	0	0	0	0	0	0	rs587782529	15.20	D	D	P	B	D	D	L	D	D	0.879	D	D	D	0.715	0.932	0.995	0.174	T	D	D	D	D	D	2.158	20.500	0.970	D	N	-0.152	2.017	-0.264	1.640	0.001	0.707	0.702	0.725	0.714	.	5.430	3.380	0.877	1.174	0.676	0.001	0.920	0.687	450	p53,_tetramerisation_domain	.	.	ID=COSV52669243;OCCURENCE=1(salivary_gland),19(breast),2(penis),1(peritoneum),4(liver),4(oesophagus),4(adrenal_gland),23(large_intestine),9(central_nervous_system),2(biliary_tract),1(ovary),1(vulva),2(NS),13(haematopoietic_and_lymphoid_tissue),9(stomach),2(soft_tissue),5(kidney),5(pancreas),1(skin),3(prostate),7(lung),4(thyroid),7(upper_aerodigestive_tract),2(endometrium)	TP53	412	0	348	75	0.177304964539007	TRUE	TRUE
ENSG00000154262.13	.	BCM	GRCh38.p13	chr17	69083312	69083312	+	C	C	T	Missense_Mutation	SNP	ENST00000284425.7	exon35	c.G4375A	p.V1459I	exonic	ENSG00000154262.13	.	nonsynonymous SNV	ENSG00000154262.13:ENST00000284425.7:exon35:c.G4375A:p.V1459I	17q24.2	C3L-03388	4.27e-05	0	0.0003	0	0	1.534e-05	0	6.982e-05	rs752169862	3.20	T	T	B	B	N	N	N	D	N	0.109	T	D	T	0.187	.	0.500	0.031	T	T	T	T	D	T	0.005	1.367	0.779	N	N	-1.237	0.202	-1.273	0.228	0.000	0.707	0.654	0.547	0.714	.	5.190	-2.610	-0.004	-3.026	-1.571	0.000	0.000	0.002	963	ABC_transporter-like;AAA+_ATPase_domain	.	.	.	ABCA6	148	0	163	42	0.204878048780488	TRUE	NA
ENSG00000152240.13	.	BCM	GRCh38.p13	chr18	46125784	46125784	+	G	G	A	Missense_Mutation	SNP	ENST00000282058.11	exon8	c.G779A	p.R260Q	exonic	ENSG00000152240.13	.	nonsynonymous SNV	ENSG00000152240.13:ENST00000282058.11:exon8:c.G779A:p.R260Q	18q21.1	C3L-03388	3.838e-05	0	0.0002	0	0	0	0	0.0001	rs749832789	7.19	D	T	P	B	D	D	M	.	N	0.630	T	T	T	0.160	0.524	0.550	0.162	T	T	T	D	T	T	3.508	24.700	0.995	D	D	0.396	4.317	0.483	5.004	0.999	0.707	0.709	0.725	0.714	.	5.780	5.780	4.584	1.161	0.676	1.000	0.994	0.959	976	.	.	.	ID=COSV99959528;OCCURENCE=1(endometrium)	HAUS1	178	0	190	30	0.136363636363636	TRUE	NA
ENSG00000118046.16	.	BCM	GRCh38.p13	chr19	1207137	1207139	+	GGG	GGG	-	In_Frame_Del	DEL	ENST00000326873.12	exon1	c.224_226del	p.R75_A76delinsT	exonic	ENSG00000118046.16	.	nonframeshift deletion	ENSG00000118046.16:ENST00000326873.12:exon1:c.224_226del:p.R75_A76delinsT	19p13.3	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STK11	314	0	213	47	0.180769230769231	TRUE	TRUE
ENSG00000198046.12	.	BCM	GRCh38.p13	chr19	56442538	56442538	+	A	A	T	Missense_Mutation	SNP	ENST00000504904.8	exon7	c.T457A	p.F153I	exonic	ENSG00000198046.12	.	nonsynonymous SNV	ENSG00000198046.12:ENST00000504904.8:exon7:c.T457A:p.F153I	19q13.43	C3L-03388	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.547	T	T	T	0.354	.	0.683	0.484	T	T	T	T	D	D	3.376	24.300	0.983	D	D	0.566	5.595	0.423	4.522	0.983	0.563	0.574	0.609	0.564	.	4.860	4.860	6.724	1.312	0.756	1.000	0.857	0.234	988	Zinc_finger_C2H2-type	.	.	.	ZNF667	161	0	193	31	0.138392857142857	TRUE	TRUE
ENSG00000125815.9	.	BCM	GRCh38.p13	chr20	23491887	23491887	+	G	G	A	Missense_Mutation	SNP	ENST00000246012.2	exon2	c.G220A	p.A74T	exonic	ENSG00000125815.9	.	nonsynonymous SNV	ENSG00000125815.9:ENST00000246012.2:exon2:c.G220A:p.A74T	20p11.21	C3L-03388	1.648e-05	0	0	0	0	2.999e-05	0	0	rs750316947	4.20	D	T	D	P	N	N	M	T	N	0.175	T	T	T	0.128	0.640	0.497	0.003	T	T	T	T	D	T	1.784	17.620	0.996	N	N	-0.041	2.369	-0.266	1.636	0.001	0.487	0.574	0.574	0.564	.	4.150	3.180	1.290	1.135	0.668	0.018	0.013	0.037	867	Cystatin_domain	.	.	.	CST8	302	0	254	48	0.158940397350993	TRUE	NA
ENSG00000087510.7	.	BCM	GRCh38.p13	chr20	56634226	56634226	+	C	C	T	Missense_Mutation	SNP	ENST00000201031.3	exon5	c.C880T	p.R294W	exonic	ENSG00000087510.7	.	nonsynonymous SNV	ENSG00000087510.7:ENST00000201031.3:exon5:c.C880T:p.R294W	20q13.31	C3L-03388	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.953	D	D	D	0.816	0.966	0.990	1.943	D	D	D	D	D	D	3.534	24.800	0.998	N	D	0.118	2.957	-0.088	2.082	1.000	0.648	0.590	0.693	0.542	.	5.300	1.940	0.895	1.026	0.599	0.297	0.915	0.288	976	Transcription_factor_AP-2,_C-terminal	.	.	.	TFAP2C	399	1	452	81	0.151969981238274	TRUE	TRUE
ENSG00000130540.14	.	BCM	GRCh38.p13	chr22	43826033	43826033	+	T	T	G	Missense_Mutation	SNP	ENST00000330884.9	exon7	c.A823C	p.K275Q	exonic	ENSG00000130540.14	.	nonsynonymous SNV	ENSG00000130540.14:ENST00000330884.9:exon7:c.A823C:p.K275Q	22q13.31	C3L-03388	.	.	.	.	.	.	.	.	.	8.20	T	T	P	B	D	D	L	D	N	0.561	T	T	D	0.491	0.533	0.341	1.161	T	T	T	T	D	D	2.824	23.100	0.994	D	D	0.358	4.093	0.466	4.867	1.000	0.707	0.610	0.725	0.655	.	5.630	5.630	7.838	1.138	0.665	1.000	1.000	1.000	900	Sulfotransferase_domain	.	.	.	SULT4A1	225	0	223	50	0.183150183150183	TRUE	TRUE
ENSG00000182872.16	.	BCM	GRCh38.p13	chrX	47175060	47175060	+	C	C	T	Nonsense_Mutation	SNP	ENST00000377604.8	exon6	c.C544T	p.Q182X	exonic	ENSG00000182872.16	.	stopgain	ENSG00000182872.16:ENST00000377604.8:exon6:c.C544T:p.Q182X	Xp11.3	C3L-03388	.	.	.	.	.	.	.	.	.	5.5	.	.	.	.	D	A	.	.	.	0.782	.	.	.	.	.	.	.	.	.	D	D	.	.	6.557	36	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	4.530	4.530	7.859	1.022	0.594	1.000	1.000	1.000	318	RNA_recognition_motif_domain	.	.	ID=COSV61311469;OCCURENCE=1(biliary_tract)	RBM10	385	1	313	154	0.329764453961456	TRUE	TRUE
ENSG00000050030.15	.	BCM	GRCh38.p13	chrX	74740211	74740211	+	C	C	T	Missense_Mutation	SNP	ENST00000055682.12	exon3	c.G4346A	p.R1449H	exonic	ENSG00000050030.15	.	nonsynonymous SNV	ENSG00000050030.15:ENST00000055682.12:exon3:c.G4346A:p.R1449H	Xq13.3	C3L-03388	2.281e-05	0	0	0.0002	0	0	0	9.882e-05	rs778760434	12.18	D	D	D	D	D	D	.	T	N	0.755	T	T	D	0.295	.	0.728	0.937	T	T	D	D	D	D	3.822	25.900	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.360	5.360	7.568	1.026	0.549	1.000	1.000	0.993	103	.	.	.	ID=COSV50022011;OCCURENCE=1(breast),1(large_intestine)	NEXMIF	231	1	196	62	0.24031007751938	TRUE	TRUE
ENSG00000171502.15	.	BCM	GRCh38.p13	chr1	85784137	85784137	+	A	A	G	Silent	SNP	ENST00000370571.7	exon50	c.T4197C	p.G1399G	exonic	ENSG00000171502.15	.	synonymous SNV	ENSG00000171502.15:ENST00000370571.7:exon50:c.T4197C:p.G1399G	1p22.3	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL24A1	150	0	142	15	0.0955414012738854	TRUE	NA
ENSG00000162771.8	.	BCM	GRCh38.p13	chr1	212626599	212626599	+	G	G	T	Silent	SNP	ENST00000294829.5	exon1	c.G1722T	p.G574G	exonic	ENSG00000162771.8	.	synonymous SNV	ENSG00000162771.8:ENST00000294829.5:exon1:c.G1722T:p.G574G	1q32.3	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM71A	291	0	292	46	0.136094674556213	TRUE	TRUE
ENSG00000177212.4	.	BCM	GRCh38.p13	chr1	248273449	248273449	+	C	C	T	Silent	SNP	ENST00000641220.1	exon2	c.G366A	p.A122A	exonic	ENSG00000177212.4	.	synonymous SNV	ENSG00000177212.4:ENST00000641220.1:exon2:c.G366A:p.A122A	1q44	C3L-03388	2.502e-05	0	0	0	0	1.516e-05	0	0.0001	rs757226382	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58814743;OCCURENCE=2(large_intestine),1(urinary_tract)	OR2T33	567	0	657	53	0.0746478873239437	NA	TRUE
ENSG00000073331.18	.	BCM	GRCh38.p13	chr4	112429223	112429223	+	C	C	T	Silent	SNP	ENST00000650871.1	exon10	c.C870T	p.A290A	exonic	ENSG00000073331.18	.	synonymous SNV	ENSG00000073331.18:ENST00000650871.1:exon10:c.C870T:p.A290A	4q25	C3L-03388	0.0011	0	0.0008	0	0	0.0001	0.0022	0.0067	rs199772759	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ALPK1	235	0	214	42	0.1640625	TRUE	NA
ENSG00000197790.1	.	BCM	GRCh38.p13	chr11	4545619	4545619	+	G	G	A	Silent	SNP	ENST00000360213.1	exon1	c.G429A	p.V143V	exonic	ENSG00000197790.1	.	synonymous SNV	ENSG00000197790.1:ENST00000360213.1:exon1:c.G429A:p.V143V	11p15.4	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR52M1	141	0	152	20	0.116279069767442	TRUE	TRUE
ENSG00000134909.18	.	BCM	GRCh38.p13	chr11	128969717	128969717	+	G	G	A	Silent	SNP	ENST00000310343.13	exon22	c.C5454T	p.A1818A	exonic	ENSG00000134909.18	.	synonymous SNV	ENSG00000134909.18:ENST00000310343.13:exon22:c.C5454T:p.A1818A	11q24.3	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARHGAP32	577	1	568	82	0.126153846153846	TRUE	TRUE
ENSG00000137878.17	.	BCM	GRCh38.p13	chr15	57709200	57709200	+	C	C	T	Silent	SNP	ENST00000299638.8	exon2	c.C600T	p.T200T	exonic	ENSG00000137878.17;ENSG00000255529.9	.	synonymous SNV	ENSG00000255529.9:ENST00000299638.8:exon2:c.C600T:p.T200T,ENSG00000137878.17:ENST00000587652.5:exon13:c.C1791T:p.T597T	15q21.3	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GCOM1	523	0	417	140	0.251346499102334	NA	TRUE
ENSG00000105428.6	.	BCM	GRCh38.p13	chr19	5456118	5456118	+	C	C	T	Silent	SNP	ENST00000222033.6	exon1	c.C627T	p.I209I	exonic	ENSG00000105428.6	.	synonymous SNV	ENSG00000105428.6:ENST00000222033.6:exon1:c.C627T:p.I209I	19p13.3	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNRF4	500	0	381	85	0.182403433476395	TRUE	TRUE
ENSG00000105143.12	.	BCM	GRCh38.p13	chr19	14956643	14956643	+	G	G	T	Silent	SNP	ENST00000221742.7	exon6	c.C1002A	p.V334V	exonic	ENSG00000105143.12	.	synonymous SNV	ENSG00000105143.12:ENST00000221742.7:exon6:c.C1002A:p.V334V	19p13.12	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC1A6	266	0	271	15	0.0524475524475524	TRUE	TRUE
ENSG00000117222.14	.	BCM	GRCh38.p13	chr1	205115903	205115903	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000117222.14	.	.	.	1q32.1	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBBP5	167	0	251	29	0.103571428571429	TRUE	NA
ENSG00000074054.18	.	BCM	GRCh38.p13	chr2	121427460	121427460	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000074054.18	.	.	.	2q14.2	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLASP1	346	0	383	69	0.152654867256637	TRUE	NA
ENSG00000161040.16	.	BCM	GRCh38.p13	chr7	103055154	103055154	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000161040.16	.	.	.	7q22.1	C3L-03388	.	.	.	.	.	.	.	.	.	2.14	T	T	.	.	U	D	.	T	N	0.149	T	T	.	0.053	0.273	0.277	.	.	.	T	T	T	T	1.903	18.510	0.799	D	N	-0.038	2.378	-0.049	2.197	0.720	0.554	0.588	0.602	0.568	.	4.880	4.000	0.592	1.008	0.599	0.969	0.994	0.950	619	.	.	.	ID=COSV57542752;OCCURENCE=1(breast)	FBXL13	142	0	220	17	0.0717299578059072	TRUE	NA
ENSG00000199151.3	.	BCM	GRCh38.p13	chr14	100874522	100874522	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000199151.3	.	.	.	14q32.2	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR337	257	0	244	51	0.172881355932203	TRUE	NA
ENSG00000126858.18	.	BCM	GRCh38.p13	chr17	32211226	32211226	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000126858.18	.	.	.	17q11.2	C3L-03388	.	.	.	.	.	.	.	.	.	6.19	T	D	P	P	D	D	.	T	N	0.749	T	T	T	0.173	0.459	0.681	0.668	T	T	T	T	D	D	2.850	23.100	0.903	D	N	0.085	2.829	0.261	3.497	0.279	0.732	0.709	0.744	0.636	.	5.600	5.600	3.571	1.026	0.599	1.000	1.000	1.000	946	.	.	.	.	RHOT1	104	0	93	18	0.162162162162162	TRUE	TRUE
ENSG00000160460.16	.	BCM	GRCh38.p13	chr19	40554773	40554773	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000160460.16	.	.	.	19q13.2	C3L-03388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPTBN4	43	0	70	14	0.166666666666667	TRUE	NA
ENSG00000143032.8	.	BCM	GRCh38.p13	chr1	90716609	90716609	+	T	T	A	Missense_Mutation	SNP	ENST00000370445.5	exon1	c.A587T	p.D196V	exonic	ENSG00000143032.8	.	nonsynonymous SNV	ENSG00000143032.8:ENST00000370445.5:exon1:c.A587T:p.D196V	1p22.2	C3N-02589	.	.	.	.	.	.	.	.	.	15.20	D	D	P	P	D	D	M	D	N	0.737	D	D	D	0.513	0.251	0.982	0.749	T	T	D	D	D	D	4.181	28.500	0.985	D	D	0.456	4.713	0.551	5.664	1.000	0.598	0.596	0.378	0.639	.	5.710	5.710	7.285	1.138	0.665	1.000	1.000	0.999	815	.	.	.	.	BARHL2	575	1	579	58	0.0910518053375196	TRUE	TRUE
ENSG00000132676.16	.	BCM	GRCh38.p13	chr1	155737049	155737049	+	T	T	A	Missense_Mutation	SNP	ENST00000368336.10	exon12	c.T1097A	p.L366H	exonic	ENSG00000132676.16	.	nonsynonymous SNV	ENSG00000132676.16:ENST00000368336.10:exon12:c.T1097A:p.L366H	1q22	C3N-02589	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.846	T	T	D	0.681	0.792	0.774	0.627	T	D	D	D	D	D	4.116	27.900	0.979	D	D	0.767	8.173	0.728	8.305	0.998	0.707	0.725	0.725	0.714	.	5.280	5.280	5.736	1.138	0.665	1.000	1.000	0.998	68	.	.	.	.	DAP3	174	0	187	31	0.142201834862385	TRUE	TRUE
ENSG00000119042.17	.	BCM	GRCh38.p13	chr2	199380434	199380434	+	C	C	T	Missense_Mutation	SNP	ENST00000417098.6	exon5	c.G527A	p.R176H	exonic	ENSG00000119042.17	.	nonsynonymous SNV	ENSG00000119042.17:ENST00000417098.6:exon5:c.G527A:p.R176H	2q33.1	C3N-02589	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.815	D	D	D	0.704	0.419	0.931	2.458	D	D	D	D	D	D	4.206	28.700	0.999	D	D	0.792	8.626	0.798	10.054	1.000	0.549	0.574	0.618	0.616	.	5.670	5.670	7.905	1.026	0.599	1.000	1.000	1.000	807	SATB,_CUT1-like_DNA-binding_domain	.	.	ID=COSV53481443;OCCURENCE=2(thyroid)	SATB2	403	1	471	33	0.0654761904761905	TRUE	TRUE
ENSG00000212122.4	.	BCM	GRCh38.p13	chr5	113434248	113434248	+	C	C	T	Missense_Mutation	SNP	ENST00000390666.4	exon1	c.G592A	p.D198N	exonic	ENSG00000212122.4	.	nonsynonymous SNV	ENSG00000212122.4:ENST00000390666.4:exon1:c.G592A:p.D198N	5q22.2	C3N-02589	0.0001	0	8.64e-05	0	0	2.998e-05	0	0.0008	rs560296208	12.20	D	D	D	D	U	D	H	T	D	0.760	D	D	T	0.573	.	0.894	0.496	T	T	T	T	D	D	3.074	23.600	0.999	D	N	0.559	5.526	0.297	3.700	0.986	0.516	0.547	0.573	0.586	.	1.240	1.240	5.275	0.395	0.333	0.999	0.963	0.855	922	Protein_kinase_domain	.	.	.	TSSK1B	265	0	252	19	0.0701107011070111	TRUE	NA
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	170079066	170079066	+	C	C	T	Missense_Mutation	SNP	ENST00000520908.7	exon49	c.C5086T	p.R1696W	exonic	ENSG00000134516.18	.	nonsynonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon49:c.C5086T:p.R1696W	5q35.1	C3N-02589	.	.	.	.	.	.	.	.	rs980056604	14.20	D	D	D	D	D	D	M	T	D	0.475	T	T	D	0.115	0.272	0.538	1.469	T	D	T	T	D	D	4.170	28.400	0.999	D	D	0.337	3.976	0.309	3.770	0.944	0.672	0.702	0.653	0.586	.	4.810	2.860	2.630	1.026	0.599	1.000	0.999	0.982	931	.	.	.	ID=COSV56944050;OCCURENCE=2(large_intestine),1(stomach),1(kidney),4(pancreas)	DOCK2	326	0	346	22	0.0597826086956522	TRUE	TRUE
ENSG00000137414.6	.	BCM	GRCh38.p13	chr6	17600999	17600999	+	C	C	T	Missense_Mutation	SNP	ENST00000259963.4	exon1	c.C590T	p.A197V	exonic	ENSG00000137414.6	.	nonsynonymous SNV	ENSG00000137414.6:ENST00000259963.4:exon1:c.C590T:p.A197V	6p22.3	C3N-02589	0.0006	0.0003	0	0	0	3.948e-05	0	0.0024	rs544019346	3.18	T	T	B	B	N	D	L	.	N	0.270	T	T	D	0.052	0.163	0.157	0.316	T	.	T	T	T	T	0.932	10.780	0.989	D	N	-0.490	1.197	-0.428	1.322	1.000	0.267	0.484	0.520	0.373	.	4.390	4.390	0.918	1.026	0.549	0.012	0.002	0.034	599	.	.	.	.	FAM8A1	360	0	367	35	0.0870646766169154	TRUE	NA
ENSG00000146221.10	.	BCM	GRCh38.p13	chr6	44286353	44286353	+	G	G	A	Missense_Mutation	SNP	ENST00000371505.5	exon3	c.C457T	p.R153C	exonic	ENSG00000146221.10	.	nonsynonymous SNV	ENSG00000146221.10:ENST00000371505.5:exon3:c.C457T:p.R153C	6p21.1	C3N-02589	2.484e-05	9.743e-05	0	0	0	1.509e-05	0	6.056e-05	rs750220971	10.19	D	D	D	P	D	D	.	T	D	0.400	T	T	D	0.325	0.511	0.444	0.520	T	T	T	T	D	D	3.989	26.900	0.999	N	D	0.642	6.383	0.588	6.072	0.998	0.549	0.590	0.590	0.530	.	4.950	4.950	2.616	0.224	0.676	1.000	0.991	0.876	783	.	.	.	ID=COSV65255298;OCCURENCE=1(oesophagus),1(pancreas)	TCTE1	177	0	183	25	0.120192307692308	TRUE	TRUE
ENSG00000078053.17	.	BCM	GRCh38.p13	chr7	38394109	38394109	+	C	C	T	Missense_Mutation	SNP	ENST00000356264.7	exon18	c.G1504A	p.G502R	exonic	ENSG00000078053.17	.	nonsynonymous SNV	ENSG00000078053.17:ENST00000356264.7:exon18:c.G1504A:p.G502R	7p14.1	C3N-02589	2.471e-05	0	8.637e-05	0.0002	0	0	0	0	rs759265550	2.20	D	T	P	B	N	N	M	T	N	0.320	T	T	T	0.132	0.174	0.807	0.226	T	T	T	T	T	T	1.601	16.380	0.987	N	N	-0.256	1.725	-0.297	1.569	1.000	0.706	0.618	0.659	0.613	.	5.660	4.780	2.041	-0.289	-0.173	0.004	0.000	0.005	856	.	.	.	ID=COSV57754878;OCCURENCE=1(lung)	AMPH	474	0	438	43	0.0893970893970894	TRUE	TRUE
ENSG00000182348.7	.	BCM	GRCh38.p13	chr7	89333668	89333668	+	T	T	C	Missense_Mutation	SNP	ENST00000333190.5	exon4	c.T686C	p.L229P	exonic	ENSG00000182348.7	.	nonsynonymous SNV	ENSG00000182348.7:ENST00000333190.5:exon4:c.T686C:p.L229P	7q21.13	C3N-02589	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	N	D	M	T	D	0.787	T	T	T	0.206	0.524	0.283	0.315	T	T	T	T	D	T	3.969	26.800	0.999	D	D	0.620	6.131	0.609	6.339	0.031	0.487	0.574	0.574	0.564	.	5.040	5.040	5.374	1.138	0.665	1.000	1.000	0.998	911	.	.	.	.	ZNF804B	142	0	172	17	0.0899470899470899	TRUE	TRUE
ENSG00000130226.17	.	BCM	GRCh38.p13	chr7	154892346	154892346	+	G	G	A	Missense_Mutation	SNP	ENST00000377770.8	exon26	c.G2464A	p.E822K	exonic	ENSG00000130226.17	.	nonsynonymous SNV	ENSG00000130226.17:ENST00000377770.8:exon26:c.G2464A:p.E822K	7q36.2	C3N-02589	.	.	.	.	.	.	.	.	.	10.19	D	D	D	D	D	D	L	T	D	0.510	T	T	T	0.283	0.860	0.093	0.809	T	T	T	T	D	.	3.703	25.400	0.999	D	D	0.451	4.674	0.392	4.302	0.995	0.646	0.574	0.645	0.613	.	4.660	4.660	7.324	1.176	0.676	1.000	0.229	0.225	958	Peptidase_S9,_prolyl_oligopeptidase,_catalytic_domain	.	.	ID=COSV59640763;OCCURENCE=1(skin)	DPP6	162	0	178	11	0.0582010582010582	TRUE	TRUE
ENSG00000147485.13	.	BCM	GRCh38.p13	chr8	51408790	51408790	+	G	G	A	Missense_Mutation	SNP	ENST00000356297.5	exon17	c.C2834T	p.A945V	exonic	ENSG00000147485.13	.	nonsynonymous SNV	ENSG00000147485.13:ENST00000356297.5:exon17:c.C2834T:p.A945V	8q11.22	C3N-02589	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	U	N	N	T	N	0.065	T	T	T	0.150	0.433	0.349	0.143	T	T	T	T	T	D	0.918	10.630	0.974	N	N	-0.721	0.778	-0.758	0.817	0.056	0.581	0.574	0.576	0.564	.	3.800	2.910	1.241	-0.861	-0.114	0.722	0.000	0.000	895	Peroxidasin,_peroxidase_domain	.	.	ID=COSV62478104;OCCURENCE=1(oesophagus),3(meninges),3(large_intestine),1(stomach),1(lung)	PXDNL	78	0	86	6	0.0652173913043478	TRUE	TRUE
ENSG00000151208.17	.	BCM	GRCh38.p13	chr10	77821473	77821473	+	G	G	A	Missense_Mutation	SNP	ENST00000372391.7	exon15	c.C3011T	p.S1004F	exonic	ENSG00000151208.17	.	nonsynonymous SNV	ENSG00000151208.17:ENST00000372391.7:exon15:c.C3011T:p.S1004F	10q22.3	C3N-02589	.	.	.	.	.	.	.	.	.	10.19	D	D	D	P	N	D	M	T	D	0.711	T	T	T	0.240	0.140	0.437	0.575	T	D	T	T	D	.	3.654	25.200	0.998	D	D	0.676	6.799	0.708	7.905	1.000	0.732	0.709	0.744	0.728	.	5.870	5.870	6.327	1.176	0.676	1.000	0.998	0.702	645	.	.	.	.	DLG5	294	0	310	31	0.0909090909090909	TRUE	TRUE
ENSG00000181761.5	.	BCM	GRCh38.p13	chr11	56122826	56122826	+	G	G	C	Missense_Mutation	SNP	ENST00000313472.3	exon1	c.G454C	p.G152R	exonic	ENSG00000181761.5	.	nonsynonymous SNV	ENSG00000181761.5:ENST00000313472.3:exon1:c.G454C:p.G152R	11q12.1	C3N-02589	.	.	.	.	.	.	.	.	.	7.20	D	D	P	P	D	N	M	T	D	0.595	T	T	T	0.152	0.777	0.626	0.251	T	T	T	T	D	D	1.912	18.580	0.997	N	N	-0.071	2.268	-0.354	1.456	0.002	0.487	0.574	0.574	0.564	.	3.620	2.690	0.830	-0.045	0.329	0.005	0.003	0.059	156	GPCR,_rhodopsin-like,_7TM	.	.	.	OR8H3	182	0	222	20	0.0826446280991736	NA	TRUE
ENSG00000130037.5	.	BCM	GRCh38.p13	chr12	5044875	5044875	+	C	C	T	Missense_Mutation	SNP	ENST00000252321.5	exon1	c.C728T	p.P243L	exonic	ENSG00000130037.5	.	nonsynonymous SNV	ENSG00000130037.5:ENST00000252321.5:exon1:c.C728T:p.P243L	12p13.32	C3N-02589	2.473e-05	9.623e-05	0	0.0002	0	0	0	0	rs767170268	17.20	D	D	D	D	U	D	M	T	D	0.924	D	D	D	0.771	0.759	0.970	1.480	T	D	D	D	D	D	3.313	24.200	0.999	D	D	0.966	12.876	0.847	11.658	1.000	0.598	0.563	0.596	0.542	.	4.770	4.770	7.847	0.962	0.524	1.000	0.915	0.210	680	.	.	.	ID=COSV52908801;OCCURENCE=1(prostate)	KCNA5	562	0	502	60	0.106761565836299	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-02589	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	262	0	296	29	0.0892307692307692	TRUE	TRUE
ENSG00000205420.11	.	BCM	GRCh38.p13	chr12	52493076	52493076	+	A	A	C	Missense_Mutation	SNP	ENST00000330722.7	exon1	c.T113G	p.V38G	exonic	ENSG00000205420.11	.	nonsynonymous SNV	ENSG00000205420.11:ENST00000330722.7:exon1:c.T113G:p.V38G	12q13.13	C3N-02589	.	.	.	.	.	.	.	.	.	9.20	D	T	P	B	D	D	M	T	D	0.386	T	T	D	0.333	0.400	0.782	2.041	T	D	T	T	D	T	2.583	22.600	0.960	D	N	0.001	2.516	0.094	2.710	1.000	0.497	0.590	0.547	0.542	.	5.240	5.240	1.441	1.312	0.756	0.966	0.842	0.522	769	Keratin_type_II_head	.	.	.	KRT6A	1004	0	887	101	0.102226720647773	NA	TRUE
ENSG00000089225.20	.	BCM	GRCh38.p13	chr12	114356025	114356025	+	C	C	T	Missense_Mutation	SNP	ENST00000405440.7	exon9	c.G1064A	p.R355H	exonic	ENSG00000089225.20	.	nonsynonymous SNV	ENSG00000089225.20:ENST00000405440.7:exon9:c.G1064A:p.R355H	12q24.21	C3N-02589	8.237e-06	9.612e-05	0	0	0	0	0	0	rs145784562	7.20	T	T	B	B	N	D	M	T	N	0.775	T	T	D	0.182	.	0.805	0.175	T	T	T	T	D	D	2.696	22.800	0.999	D	D	0.235	3.463	0.353	4.038	1.000	0.520	0.616	0.441	0.564	.	5.270	5.270	7.568	1.026	0.599	1.000	0.779	0.922	946	.	.	.	ID=COSV59858803;OCCURENCE=1(large_intestine)	TBX5	482	0	496	51	0.093235831809872	TRUE	TRUE
ENSG00000189167.12	.	BCM	GRCh38.p13	chr13	32311490	32311490	+	G	G	A	Missense_Mutation	SNP	ENST00000533490.7	exon3	c.C436T	p.R146W	exonic	ENSG00000189167.12	.	nonsynonymous SNV	ENSG00000189167.12:ENST00000533490.7:exon3:c.C436T:p.R146W	13q13.1	C3N-02589	.	.	.	.	.	.	.	.	.	3.19	D	D	B	B	N	N	M	.	N	0.107	T	T	T	0.027	0.401	0.122	.	T	T	T	T	T	T	1.270	14.170	0.992	N	N	-0.967	0.440	-1.033	0.449	1.000	0.578	0.547	0.608	0.613	.	4.740	-0.895	1.470	0.189	0.674	0.006	0.000	0.006	868	.	.	.	ID=COSV61525160;OCCURENCE=1(large_intestine)	ZAR1L	207	0	173	20	0.103626943005181	TRUE	TRUE
ENSG00000150893.11	.	BCM	GRCh38.p13	chr13	38687598	38687598	+	G	G	A	Missense_Mutation	SNP	ENST00000280481.9	exon1	c.G254A	p.R85H	exonic	ENSG00000150893.11	.	nonsynonymous SNV	ENSG00000150893.11:ENST00000280481.9:exon1:c.G254A:p.R85H	13q13.3	C3N-02589	.	.	.	.	.	.	.	.	.	10.15	D	D	.	.	D	D	.	T	D	0.397	T	T	D	0.443	0.509	0.688	0.629	T	.	D	T	D	.	4.564	32	1.000	D	D	0.890	10.793	0.876	12.762	1.000	0.598	0.596	0.520	0.639	.	5.460	5.460	7.860	1.176	0.671	1.000	0.998	0.999	938	.	.	.	.	FREM2	72	0	73	4	0.051948051948052	TRUE	NA
ENSG00000187498.16	.	BCM	GRCh38.p13	chr13	110150403	110150403	+	G	G	A	Missense_Mutation	SNP	ENST00000375820.10	exon52	c.C4970T	p.T1657M	exonic	ENSG00000187498.16	.	nonsynonymous SNV	ENSG00000187498.16:ENST00000375820.10:exon52:c.C4970T:p.T1657M	13q34	C3N-02589	3.41e-05	0	8.956e-05	0	0	4.621e-05	0	0	rs779139113	17.20	D	D	D	P	N	D	M	D	D	0.359	D	D	D	0.671	0.559	0.830	0.399	T	D	D	D	D	D	4.061	27.400	0.997	D	D	0.510	5.112	0.438	4.641	1.000	0.706	0.563	0.710	0.711	.	5.080	4.220	9.539	1.176	0.676	1.000	0.605	0.891	994	Collagen_IV,_non-collagenous	.	.	ID=COSV65427289;OCCURENCE=1(small_intestine)	COL4A1	562	1	576	39	0.0634146341463415	TRUE	TRUE
ENSG00000188869.13	.	BCM	GRCh38.p13	chr15	81359454	81359454	+	C	C	T	Missense_Mutation	SNP	ENST00000359440.6	exon5	c.G412A	p.V138I	exonic	ENSG00000188869.13	.	nonsynonymous SNV	ENSG00000188869.13:ENST00000359440.6:exon5:c.G412A:p.V138I	15q25.1	C3N-02589	3.238e-05	0.0002	0	0.0002	0	0	0	0	rs201479309	11.20	D	D	D	D	D	D	M	T	N	0.759	T	T	D	0.230	.	0.374	0.578	T	T	T	T	T	D	3.433	24.500	0.998	D	D	0.663	6.638	0.642	6.794	1.000	0.487	0.590	0.574	0.542	.	5.950	5.950	7.114	1.026	0.599	1.000	0.915	0.980	934	.	.	.	.	TMC3	155	0	170	10	0.0555555555555556	TRUE	NA
ENSG00000196557.13	.	BCM	GRCh38.p13	chr16	1200269	1200269	+	A	A	G	Missense_Mutation	SNP	ENST00000348261.11	exon7	c.A817G	p.T273A	exonic	ENSG00000196557.13	.	nonsynonymous SNV	ENSG00000196557.13:ENST00000348261.11:exon7:c.A817G:p.T273A	16p13.3	C3N-02589	.	.	.	.	.	.	.	.	.	7.20	T	T	P	B	N	N	L	D	N	0.436	D	D	D	0.389	0.523	0.901	.	T	T	D	T	T	T	2.503	22.400	0.674	D	D	0.058	2.723	0.152	2.958	1.000	0.718	0.627	0.571	0.563	.	4.400	4.400	4.936	1.207	0.682	1.000	0.983	0.944	940	Ion_transport_domain	.	.	.	CACNA1H	107	0	141	12	0.0784313725490196	TRUE	TRUE
ENSG00000008516.17	.	BCM	GRCh38.p13	chr16	3057382	3057382	+	C	C	T	Missense_Mutation	SNP	ENST00000336577.9	exon6	c.C911T	p.S304L	exonic	ENSG00000008516.17	.	nonsynonymous SNV	ENSG00000008516.17:ENST00000336577.9:exon6:c.C911T:p.S304L	16p13.3	C3N-02589	7.51e-05	0	0	0.0001	0	0.0001	0	0	rs370333247	0.20	T	T	B	B	N	N	N	T	N	0.085	T	T	T	0.016	.	0.088	0.131	T	T	T	T	T	T	0.643	7.922	0.399	N	N	-1.391	0.121	-1.409	0.147	1.000	0.635	0.634	0.644	0.528	.	4.470	-3.690	-0.220	-0.318	-0.339	0.001	0.000	0.000	794	.	.	.	ID=COSV60678562;OCCURENCE=1(central_nervous_system),1(NS)	MMP25	138	0	148	24	0.13953488372093	TRUE	TRUE
ENSG00000074755.15	.	BCM	GRCh38.p13	chr17	4102350	4102350	+	C	C	T	Missense_Mutation	SNP	ENST00000381638.7	exon9	c.G1639A	p.E547K	exonic	ENSG00000074755.15	.	nonsynonymous SNV	ENSG00000074755.15:ENST00000381638.7:exon9:c.G1639A:p.E547K	17p13.2	C3N-02589	8.24e-06	0	0	0	0	1.499e-05	0	0	rs748685711	13.20	D	D	D	D	D	D	L	T	N	0.796	T	T	D	0.209	0.249	0.068	0.694	T	T	D	D	D	D	4.124	28.000	0.999	D	D	0.692	7.002	0.724	8.232	1.000	0.722	0.586	0.651	0.735	.	5.710	5.710	7.138	1.026	0.599	1.000	0.975	0.971	270	.	.	.	.	ZZEF1	150	0	178	19	0.0964467005076142	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675161	7675161	+	G	G	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.C451A	p.P151T	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.C451A:p.P151T	17p13.1	C3N-02589	.	.	.	.	.	.	.	.	rs28934874	19.20	D	D	D	D	D	D	M	D	D	0.920	D	D	D	0.911	0.959	0.977	1.736	T	D	D	D	D	D	3.466	24.600	0.997	D	D	0.748	7.848	0.676	7.333	1.000	0.722	0.698	0.698	0.735	.	5.590	5.590	8.002	1.176	0.676	1.000	0.189	0.692	434	p53,_DNA-binding_domain	.	.	ID=COSV52676321;OCCURENCE=2(breast),1(genital_tract),2(oesophagus),5(large_intestine),1(central_nervous_system),4(ovary),5(stomach),2(urinary_tract),2(pancreas),2(lung),1(thyroid),2(upper_aerodigestive_tract)	TP53	242	0	212	27	0.112970711297071	TRUE	TRUE
ENSG00000136492.9	.	BCM	GRCh38.p13	chr17	61780893	61780893	+	G	G	A	Nonsense_Mutation	SNP	ENST00000259008.7	exon12	c.C1741T	p.R581X	exonic	ENSG00000136492.9	.	stopgain	ENSG00000136492.9:ENST00000259008.7:exon12:c.C1741T:p.R581X	17q23.2	C3N-02589	8.238e-06	0	0	0.0001	0	0	0	0	rs780020495	4.6	.	.	.	.	N	A	.	.	.	0.905	.	.	.	.	.	.	.	.	.	D	D	.	.	6.545	36	0.997	D	N	0.724	7.475	0.508	5.232	0.000	0.615	0.634	0.659	0.655	.	5.250	1.640	0.936	0.186	0.676	0.919	0.996	0.999	54	.	.	.	ID=COSV99370649;OCCURENCE=1(stomach),1(skin),1(prostate)	BRIP1	290	0	290	27	0.0851735015772871	TRUE	NA
ENSG00000154655.15	.	BCM	GRCh38.p13	chr18	6241432	6241432	+	A	A	T	Missense_Mutation	SNP	ENST00000400105.6	exon8	c.T478A	p.F160I	exonic	ENSG00000154655.15	.	nonsynonymous SNV	ENSG00000154655.15:ENST00000400105.6:exon8:c.T478A:p.F160I	18p11.31	C3N-02589	.	.	.	.	.	.	.	.	.	7.20	D	D	P	B	N	D	M	T	D	0.290	T	T	T	0.195	0.738	0.612	.	T	T	T	T	D	T	2.851	23.100	0.970	D	N	0.171	3.178	0.143	2.916	0.000	0.638	0.670	0.602	0.564	.	5.450	1.410	3.301	1.288	0.691	1.000	0.998	0.979	933	.	.	.	.	L3MBTL4	121	1	150	9	0.0566037735849057	TRUE	TRUE
ENSG00000180777.14	.	BCM	GRCh38.p13	chr18	14797785	14797785	+	A	A	T	Missense_Mutation	SNP	ENST00000358984.9	exon20	c.A1960T	p.T654S	exonic	ENSG00000180777.14	.	nonsynonymous SNV	ENSG00000180777.14:ENST00000358984.9:exon20:c.A1960T:p.T654S	18p11.21	C3N-02589	.	.	.	.	.	.	.	.	.	1.17	T	T	.	.	.	N	N	T	N	0.035	T	T	T	0.037	0.140	0.153	0.029	D	T	T	T	T	T	0.188	2.983	0.578	N	N	-0.566	1.050	-0.864	0.669	0.000	0.487	0.574	0.574	0.564	.	0.920	-0.320	-0.615	-1.181	0.263	0.034	0.000	0.004	923	.	.	.	.	ANKRD30B	168	0	176	13	0.0687830687830688	NA	TRUE
ENSG00000198551.10	.	BCM	GRCh38.p13	chr19	11614884	11614884	+	T	T	C	Missense_Mutation	SNP	ENST00000361113.10	exon3	c.T188C	p.I63T	exonic	ENSG00000198551.10	.	nonsynonymous SNV	ENSG00000198551.10:ENST00000361113.10:exon3:c.T188C:p.I63T	19p13.2	C3N-02589	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.064	T	T	T	0.019	0.329	0.014	0.305	T	T	T	T	T	T	0.496	6.464	0.453	N	N	-1.645	0.046	-1.724	0.046	0.000	0.563	0.546	0.609	0.636	.	1.840	-2.170	0.034	-0.663	-1.062	0.004	0.020	0.175	798	Krueppel-associated_box	.	.	.	ZNF627	131	0	165	12	0.0677966101694915	TRUE	TRUE
ENSG00000161681.15	.	BCM	GRCh38.p13	chr19	50662231	50662231	+	G	G	A	Missense_Mutation	SNP	ENST00000293441.5	exon23	c.C6220T	p.R2074C	exonic	ENSG00000161681.15	.	nonsynonymous SNV	ENSG00000161681.15:ENST00000293441.5:exon23:c.C6220T:p.R2074C	19q13.33	C3N-02589	6.919e-05	0	0	0.0004	0	4.701e-05	0	0.0001	rs549670535	12.20	D	D	D	D	U	D	L	T	D	0.653	T	T	D	0.206	.	0.551	0.916	D	D	T	T	T	D	4.329	29.800	0.985	D	D	0.438	4.585	0.379	4.210	1.000	0.516	0.547	0.576	0.586	.	3.550	3.550	5.467	1.164	0.654	1.000	0.910	0.906	861	.	.	.	ID=COSV53263287;OCCURENCE=1(stomach),1(prostate)	SHANK1	102	0	100	17	0.145299145299145	TRUE	NA
ENSG00000242019.1	.	BCM	GRCh38.p13	chr19	54727752	54727752	+	G	G	A	Missense_Mutation	SNP	ENST00000291860.1	exon4	c.G497A	p.R166H	exonic	ENSG00000242019.1	.	nonsynonymous SNV	ENSG00000242019.1:ENST00000291860.1:exon4:c.G497A:p.R166H	19q13.42	C3N-02589	2.253e-05	0	0	0	0	3.967e-05	0	0	rs201591361	0.14	T	T	.	.	.	N	.	T	N	0.030	T	T	T	0.010	.	0.043	2.110	T	.	T	T	T	.	-0.329	0.270	0.471	N	N	-1.650	0.045	-1.702	0.051	0.000	0.487	0.574	0.574	0.564	.	1.200	-0.022	-0.798	0.012	-0.349	0.000	0.000	0.000	952	Immunoglobulin_subtype	.	.	ID=COSV52549600;OCCURENCE=1(large_intestine),1(lung)	KIR3DL3	423	0	442	36	0.0753138075313808	TRUE	NA
ENSG00000198131.14	.	BCM	GRCh38.p13	chr19	58261747	58261747	+	G	G	A	Missense_Mutation	SNP	ENST00000269829.5	exon4	c.G1141A	p.E381K	exonic	ENSG00000198131.14	.	nonsynonymous SNV	ENSG00000198131.14:ENST00000269829.5:exon4:c.G1141A:p.E381K	19q13.43	C3N-02589	8.238e-06	0	8.64e-05	0	0	0	0	0	rs756389353	1.19	T	T	P	B	.	N	N	T	D	0.132	T	T	T	0.051	0.369	0.234	0.104	T	T	T	T	T	T	1.161	13.320	0.995	N	N	-0.983	0.422	-1.035	0.446	0.052	0.672	0.702	0.702	0.742	.	2.900	0.492	-1.530	0.163	0.597	0.000	0.881	0.984	964	Zinc_finger_C2H2-type	.	.	.	ZNF544	225	0	233	17	0.068	TRUE	TRUE
ENSG00000101346.14	.	BCM	GRCh38.p13	chr20	32215323	32215323	+	C	C	T	Missense_Mutation	SNP	ENST00000375749.8	exon3	c.C301T	p.R101W	exonic	ENSG00000101346.14	.	nonsynonymous SNV	ENSG00000101346.14:ENST00000375749.8:exon3:c.C301T:p.R101W	20q11.21	C3N-02589	1.648e-05	0	8.639e-05	0	0	1.499e-05	0	0	rs770978581	15.20	D	D	D	D	D	D	M	T	D	0.945	T	T	D	0.485	0.718	0.423	0.721	T	T	D	D	D	D	3.968	26.800	0.999	D	D	0.656	6.549	0.571	5.875	1.000	0.732	0.725	0.744	0.714	.	5.640	3.650	4.582	-0.244	-0.189	1.000	0.995	0.983	352	.	.	.	ID=COSV65260262;OCCURENCE=1(central_nervous_system)	POFUT1	113	0	123	11	0.082089552238806	TRUE	TRUE
ENSG00000177138.17	.	BCM	GRCh38.p13	chrX	9027885	9027885	+	G	G	A	Missense_Mutation	SNP	ENST00000327220.10	exon7	c.C475T	p.R159C	exonic	ENSG00000177138.17	.	nonsynonymous SNV	ENSG00000177138.17:ENST00000327220.10:exon7:c.C475T:p.R159C	Xp22.31	C3N-02589	5.705e-05	0	0	0	0	4.173e-05	0	0.0003	rs201073413	3.17	T	D	D	D	.	N	N	.	N	0.179	T	T	T	0.098	.	0.376	0.387	T	T	T	T	T	T	2.012	19.350	0.991	N	.	.	.	.	.	0.235	.	.	.	.	.	1.310	-0.848	0.535	0.447	0.373	0.446	0.002	0.027	987	XLR/SYCP3/FAM9_domain	.	.	.	FAM9B	108	0	150	29	0.162011173184358	TRUE	NA
ENSG00000142583.18	.	BCM	GRCh38.p13	chr1	9039591	9039591	+	G	G	A	Silent	SNP	ENST00000377424.9	exon8	c.C957T	p.A319A	exonic	ENSG00000142583.18	.	synonymous SNV	ENSG00000142583.18:ENST00000377424.9:exon8:c.C957T:p.A319A	1p36.23	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66237760;OCCURENCE=1(prostate)	SLC2A5	98	0	104	11	0.0956521739130435	TRUE	TRUE
ENSG00000143001.5	.	BCM	GRCh38.p13	chr1	54986243	54986243	+	G	G	A	Silent	SNP	ENST00000371268.4	exon2	c.G162A	p.T54T	exonic	ENSG00000143001.5	.	synonymous SNV	ENSG00000143001.5:ENST00000371268.4:exon2:c.G162A:p.T54T	1p32.3	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100987742;OCCURENCE=1(endometrium)	TMEM61	254	0	277	28	0.0918032786885246	TRUE	NA
ENSG00000185842.15	.	BCM	GRCh38.p13	chr1	225152862	225152862	+	G	G	A	Silent	SNP	ENST00000445597.6	exon20	c.G3894A	p.A1298A	exonic	ENSG00000185842.15	.	synonymous SNV	ENSG00000185842.15:ENST00000445597.6:exon20:c.G3894A:p.A1298A	1q42.12	C3N-02589	0.0004	0.0028	0.0025	0	0	0.0002	0	0	rs139949596	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH14	207	0	250	19	0.0706319702602231	TRUE	NA
ENSG00000135766.9	.	BCM	GRCh38.p13	chr1	231421025	231421025	+	G	G	T	Silent	SNP	ENST00000366641.4	exon1	c.C864A	p.G288G	exonic	ENSG00000135766.9	.	synonymous SNV	ENSG00000135766.9:ENST00000366641.4:exon1:c.C864A:p.G288G	1q42.2	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EGLN1	510	0	527	97	0.155448717948718	TRUE	TRUE
ENSG00000196539.3	.	BCM	GRCh38.p13	chr1	248474121	248474121	+	C	C	T	Silent	SNP	ENST00000359594.3	exon1	c.C771T	p.F257F	exonic	ENSG00000196539.3	.	synonymous SNV	ENSG00000196539.3:ENST00000359594.3:exon1:c.C771T:p.F257F	1q44	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62081928;OCCURENCE=1(central_nervous_system)	OR2T3	342	1	416	23	0.0523917995444191	NA	TRUE
ENSG00000074047.21	.	BCM	GRCh38.p13	chr2	120988905	120988905	+	G	G	A	Silent	SNP	ENST00000452319.5	exon14	c.G2991A	p.P997P	exonic	ENSG00000074047.21	.	synonymous SNV	ENSG00000074047.21:ENST00000452319.5:exon14:c.G2991A:p.P997P	2q14.2	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GLI2	512	0	471	47	0.0907335907335907	TRUE	TRUE
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	141062243	141062243	+	G	G	A	Silent	SNP	ENST00000389484.8	exon8	c.C1044T	p.V348V	exonic	ENSG00000168702.18	.	synonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon8:c.C1044T:p.V348V	2q22.1	C3N-02589	3.332e-05	9.645e-05	8.809e-05	0	0	0	0	0.0001	rs200690342	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67230631;OCCURENCE=2(large_intestine)	LRP1B	93	0	122	15	0.109489051094891	TRUE	TRUE
ENSG00000138795.10	.	BCM	GRCh38.p13	chr4	108083415	108083415	+	G	G	A	Silent	SNP	ENST00000265165.6	exon5	c.C579T	p.I193I	exonic	ENSG00000138795.10	.	synonymous SNV	ENSG00000138795.10:ENST00000265165.6:exon5:c.C579T:p.I193I	4q25	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LEF1	202	0	180	25	0.121951219512195	TRUE	TRUE
ENSG00000204310.13	.	BCM	GRCh38.p13	chr6	32169411	32169411	+	C	C	T	Silent	SNP	ENST00000375107.8	exon7	c.G717A	p.T239T	exonic	ENSG00000204310.13	.	synonymous SNV	ENSG00000204310.13:ENST00000375107.8:exon7:c.G717A:p.T239T	6p21.32	C3N-02589	.	.	.	.	.	.	.	.	rs937993066	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61247738;OCCURENCE=1(large_intestine)	AGPAT1	204	0	246	24	0.0888888888888889	TRUE	TRUE
ENSG00000204267.16	.	BCM	GRCh38.p13	chr6	32835232	32835232	+	C	C	T	Silent	SNP	ENST00000374897.4	exon5	c.G867A	p.S289S	exonic	ENSG00000204267.16;ENSG00000250264.1	.	synonymous SNV	ENSG00000204267.16:ENST00000374897.4:exon5:c.G867A:p.S289S,ENSG00000250264.1:ENST00000452392.2:exon5:c.G867A:p.S289S	6p21.32	C3N-02589	8.606e-06	0	0	0	0	1.579e-05	0	0	rs775338272	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66499058;OCCURENCE=1(large_intestine),1(endometrium)	TAP2	691	0	750	74	0.0898058252427184	TRUE	TRUE
ENSG00000272391.6	.	BCM	GRCh38.p13	chr7	75441551	75441551	+	T	T	C	Silent	SNP	ENST00000607367.5	exon2	c.A672G	p.T224T	exonic	ENSG00000272391.6	.	synonymous SNV	ENSG00000272391.6:ENST00000607367.5:exon2:c.A672G:p.T224T	7q11.23	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	POM121C	412	0	411	33	0.0743243243243243	NA	TRUE
ENSG00000155926.14	.	BCM	GRCh38.p13	chr8	133060131	133060131	+	C	C	T	Silent	SNP	ENST00000338087.10	exon3	c.G30A	p.A10A	exonic	ENSG00000155926.14	.	synonymous SNV	ENSG00000155926.14:ENST00000338087.10:exon3:c.G30A:p.A10A	8q24.22	C3N-02589	0.0001	9.61e-05	8.637e-05	0.0003	0	4.504e-05	0	0.0004	rs202000953	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99598584;OCCURENCE=1(central_nervous_system)	SLA	112	0	111	13	0.104838709677419	TRUE	NA
ENSG00000165124.18	.	BCM	GRCh38.p13	chr9	110427725	110427725	+	A	A	G	Silent	SNP	ENST00000374469.6	exon36	c.T5841C	p.A1947A	exonic	ENSG00000165124.18	.	synonymous SNV	ENSG00000165124.18:ENST00000374469.6:exon36:c.T5841C:p.A1947A	9q31.3	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SVEP1	136	0	161	9	0.0529411764705882	TRUE	TRUE
ENSG00000136866.13	.	BCM	GRCh38.p13	chr9	113043631	113043631	+	G	G	C	Silent	SNP	ENST00000374227.7	exon4	c.C987G	p.A329A	exonic	ENSG00000136866.13	.	synonymous SNV	ENSG00000136866.13:ENST00000374227.7:exon4:c.C987G:p.A329A	9q32	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFP37	163	0	196	19	0.0883720930232558	TRUE	TRUE
ENSG00000148357.16	.	BCM	GRCh38.p13	chr9	130354932	130354932	+	C	C	T	Silent	SNP	ENST00000624552.3	exon32	c.C5031T	p.D1677D	exonic	ENSG00000148357.16	.	synonymous SNV	ENSG00000148357.16:ENST00000624552.3:exon32:c.C5031T:p.D1677D	9q34.11	C3N-02589	0.0030	0.0013	0	0	0	0.0021	0.0066	0.0041	rs142117460	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HMCN2	343	0	345	30	0.08	TRUE	NA
ENSG00000110675.13	.	BCM	GRCh38.p13	chr11	107665152	107665152	+	G	G	A	Silent	SNP	ENST00000265840.12	exon12	c.G960A	p.A320A	exonic	ENSG00000110675.13	.	synonymous SNV	ENSG00000110675.13:ENST00000265840.12:exon12:c.G960A:p.A320A	11q22.3	C3N-02589	2.485e-05	0	0	0	0	2.998e-05	0	6.057e-05	rs764635964	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56192809;OCCURENCE=3(stomach),1(soft_tissue),2(pancreas)	ELMOD1	185	0	187	11	0.0555555555555556	TRUE	TRUE
ENSG00000149305.7	.	BCM	GRCh38.p13	chr11	113932997	113932997	+	G	G	A	Silent	SNP	ENST00000260191.7	exon6	c.G600A	p.A200A	exonic	ENSG00000149305.7	.	synonymous SNV	ENSG00000149305.7:ENST00000260191.7:exon6:c.G600A:p.A200A	11q23.2	C3N-02589	9.066e-05	0.0002	8.645e-05	0.0001	0	2.999e-05	0	0.0003	rs117682771	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HTR3B	185	1	219	14	0.0600858369098712	TRUE	NA
ENSG00000177990.12	.	BCM	GRCh38.p13	chr12	63624045	63624045	+	A	A	T	Silent	SNP	ENST00000324472.9	exon8	c.T948A	p.I316I	exonic	ENSG00000177990.12	.	synonymous SNV	ENSG00000177990.12:ENST00000324472.9:exon8:c.T948A:p.I316I	12q14.2	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DPY19L2	213	0	197	28	0.124444444444444	NA	TRUE
ENSG00000092098.17	.	BCM	GRCh38.p13	chr14	24159871	24159871	+	C	C	T	Silent	SNP	ENST00000324103.11	exon19	c.C2907T	p.C969C	exonic	ENSG00000092098.17;ENSG00000259529.2	.	synonymous SNV	ENSG00000092098.17:ENST00000324103.11:exon19:c.C2907T:p.C969C,ENSG00000259529.2:ENST00000558468.2:exon19:c.C2907T:p.C969C	14q12	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF31	60	0	86	9	0.0947368421052632	TRUE	TRUE
ENSG00000184304.16	.	BCM	GRCh38.p13	chr14	29577355	29577355	+	G	G	A	Silent	SNP	ENST00000331968.11	exon18	c.C2622T	p.G874G	exonic	ENSG00000184304.16	.	synonymous SNV	ENSG00000184304.16:ENST00000331968.11:exon18:c.C2622T:p.G874G	14q12	C3N-02589	1.649e-05	0	0	0.0001	0	1.499e-05	0	0	rs767961425	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRKD1	528	0	569	57	0.0910543130990415	TRUE	NA
ENSG00000248905.10	.	BCM	GRCh38.p13	chr15	33154483	33154483	+	G	G	A	Silent	SNP	ENST00000616417.5	exon4	c.C432T	p.P144P	exonic	ENSG00000248905.10	.	synonymous SNV	ENSG00000248905.10:ENST00000616417.5:exon4:c.C432T:p.P144P	15q13.3	C3N-02589	7.055e-05	0	0	0	0	0	0	0.0001	rs193208337	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FMN1	279	0	296	32	0.0975609756097561	TRUE	NA
ENSG00000166813.15	.	BCM	GRCh38.p13	chr15	89648588	89648588	+	G	G	A	Silent	SNP	ENST00000394412.8	exon5	c.C1110T	p.S370S	exonic	ENSG00000166813.15	.	synonymous SNV	ENSG00000166813.15:ENST00000394412.8:exon5:c.C1110T:p.S370S	15q26.1	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIF7	298	0	261	24	0.0842105263157895	TRUE	TRUE
ENSG00000140750.17	.	BCM	GRCh38.p13	chr16	24959914	24959914	+	A	A	T	Silent	SNP	ENST00000289968.11	exon8	c.T639A	p.V213V	exonic	ENSG00000140750.17	.	synonymous SNV	ENSG00000140750.17:ENST00000289968.11:exon8:c.T639A:p.V213V	16p12.1	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARHGAP17	199	0	232	20	0.0793650793650794	TRUE	TRUE
ENSG00000080603.17	.	BCM	GRCh38.p13	chr16	30723924	30723924	+	G	G	A	Silent	SNP	ENST00000380361.7	exon20	c.G3969A	p.P1323P	exonic	ENSG00000080603.17;ENSG00000282034.1	.	synonymous SNV	ENSG00000282034.1:ENST00000380361.7:exon20:c.G3969A:p.P1323P,ENSG00000080603.17:ENST00000262518.9:exon25:c.G4500A:p.P1500P	16p11.2	C3N-02589	1.648e-05	0	0	0	0	2.997e-05	0	0	rs574491718	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SRCAP	259	0	257	29	0.101398601398601	TRUE	NA
ENSG00000125651.14	.	BCM	GRCh38.p13	chr19	6380461	6380461	+	G	G	A	Silent	SNP	ENST00000394456.10	exon13	c.C1374T	p.A458A	exonic	ENSG00000125651.14	.	synonymous SNV	ENSG00000125651.14:ENST00000394456.10:exon13:c.C1374T:p.A458A	19p13.3	C3N-02589	4.942e-05	0.0002	0	0	0	4.495e-05	0	6.056e-05	rs370032823	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55531770;OCCURENCE=1(large_intestine),1(biliary_tract)	GTF2F1	395	0	420	50	0.106382978723404	TRUE	TRUE
ENSG00000161681.15	.	BCM	GRCh38.p13	chr19	50702522	50702522	+	G	G	A	Silent	SNP	ENST00000293441.5	exon11	c.C1692T	p.S564S	exonic	ENSG00000161681.15	.	synonymous SNV	ENSG00000161681.15:ENST00000293441.5:exon11:c.C1692T:p.S564S	19q13.33	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SHANK1	174	1	176	22	0.111111111111111	TRUE	TRUE
ENSG00000160224.17	.	BCM	GRCh38.p13	chr21	44288421	44288421	+	C	C	T	Silent	SNP	ENST00000291582.6	exon5	c.C615T	p.A205A	exonic	ENSG00000160224.17	.	synonymous SNV	ENSG00000160224.17:ENST00000291582.6:exon5:c.C615T:p.A205A	21q22.3	C3N-02589	6.66e-05	9.771e-05	0	0	0	0.0001	0	0	rs143784684	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AIRE	119	0	126	14	0.1	TRUE	NA
ENSG00000175718.10	.	BCM	GRCh38.p13	chrX	115190377	115190377	+	C	C	T	Silent	SNP	ENST00000424776.5	exon1	c.C936T	p.G312G	exonic	ENSG00000175718.10	.	synonymous SNV	ENSG00000175718.10:ENST00000424776.5:exon1:c.C936T:p.G312G	Xq23	C3N-02589	0.0002	0.0006	0	0	0	0	0	0.0004	rs782770623	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100407533;OCCURENCE=1(endometrium)	RBMXL3	56	1	44	5	0.102040816326531	TRUE	NA
ENSG00000047365.12	.	BCM	GRCh38.p13	chr4	36260002	36260002	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000047365.12;ENSG00000247193.3	dist=15488;dist=11568	.	.	4p14	C3N-02589	0	0	0	0	.	0	0	0	rs773777896	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARAP2	112	0	134	20	0.12987012987013	TRUE	NA
ENSG00000234432.4	.	BCM	GRCh38.p13	chr7	5427976	5427976	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000234432.4	.	.	.	7p22.1	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC092171.3	351	0	332	30	0.0828729281767956	TRUE	NA
ENSG00000055118.15	.	BCM	GRCh38.p13	chr7	150949934	150949934	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000055118.15	.	.	.	7q36.1	C3N-02589	0.0002	0.0014	0	0	0	0	0	0.0002	rs370393086	4.12	.	D	.	.	.	N	.	.	.	0.072	D	D	D	0.318	.	0.043	.	.	T	T	T	T	T	0.318	4.493	0.946	N	N	-1.012	0.392	-1.074	0.403	1.000	0.560	0.578	0.269	0.563	.	3.130	1.220	0.033	-1.587	-2.391	0.000	0.000	0.001	754	.	.	.	ID=COSV104568874;OCCURENCE=2(haematopoietic_and_lymphoid_tissue)	KCNH2	122	0	131	10	0.0709219858156028	TRUE	NA
ENSG00000166343.10	.	BCM	GRCh38.p13	chr10	73429624	73429624	+	A	A	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000166343.10	.	.	.	10q22.2	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MSS51	172	0	226	15	0.0622406639004149	TRUE	NA
ENSG00000205494.9	.	BCM	GRCh38.p13	chr11	5121373	5121373	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000205494.9	.	.	.	11p15.4	C3N-02589	4.307e-05	9.789e-05	0	0	0	4.601e-05	0	7.559e-05	rs753901401	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR52A4P	36	0	49	8	0.140350877192982	TRUE	NA
ENSG00000237594.2	.	BCM	GRCh38.p13	chr21	31559394	31559394	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000237594.2	.	.	.	21q22.11	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AP000251.1	40	0	42	6	0.125	TRUE	NA
ENSG00000223611.5	.	BCM	GRCh38.p13	chrX	24314119	24314119	+	G	G	A	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000223611.5	dist=804	.	.	Xp22.11	C3N-02589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUPT20HL2	56	0	63	5	0.0735294117647059	TRUE	NA
ENSG00000049089.15	.	BCM	GRCh38.p13	chr1	40317194	40317194	+	C	C	T	Missense_Mutation	SNP	ENST00000372748.8	exon1	c.G4A	p.A2T	exonic	ENSG00000049089.15	.	nonsynonymous SNV	ENSG00000049089.15:ENST00000372748.8:exon1:c.G4A:p.A2T	1p34.2	C3L-03356	.	.	.	.	.	.	.	.	.	4.20	D	T	B	B	N	N	L	D	N	0.172	T	D	D	0.275	0.182	0.694	0.251	T	T	T	T	T	T	1.793	17.680	0.931	N	N	-0.590	1.006	-0.494	1.212	1.000	0.658	0.609	0.619	0.555	.	4.110	2.160	-0.650	-0.008	0.462	0.000	0.710	0.629	409	.	.	.	.	COL9A2	222	0	585	46	0.0729001584786054	TRUE	TRUE
ENSG00000150551.11	.	BCM	GRCh38.p13	chr2	132646233	132646233	+	C	C	T	Missense_Mutation	SNP	ENST00000397463.3	exon3	c.G238A	p.A80T	exonic	ENSG00000150551.11	.	nonsynonymous SNV	ENSG00000150551.11:ENST00000397463.3:exon3:c.G238A:p.A80T	2q21.2	C3L-03356	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	L	D	D	0.219	T	T	D	0.290	0.398	0.822	1.150	T	T	T	T	D	D	2.335	21.800	0.998	D	N	-0.019	2.444	0.148	2.939	0.995	0.742	0.574	0.775	0.714	.	5.700	3.750	1.952	1.026	0.599	1.000	0.991	0.991	964	.	.	.	.	LYPD1	19	0	50	4	0.0740740740740741	TRUE	NA
ENSG00000163513.19	.	BCM	GRCh38.p13	chr3	30644842	30644842	+	C	C	T	Nonsense_Mutation	SNP	ENST00000295754.10	exon2	c.C190T	p.Q64X	exonic	ENSG00000163513.19	.	stopgain	ENSG00000163513.19:ENST00000295754.10:exon2:c.C190T:p.Q64X	3p24.1	C3L-03356	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.897	.	.	.	.	.	.	.	.	.	D	D	.	.	7.467	38	0.998	D	N	0.940	12.122	0.795	9.978	1.000	0.706	0.617	0.710	0.723	.	5.660	4.750	1.685	1.026	0.597	1.000	0.997	0.990	953	Transforming_growth_factor_beta_receptor_2_ectodomain	.	.	.	TGFBR2	233	0	464	37	0.0738522954091816	TRUE	TRUE
ENSG00000113083.14	.	BCM	GRCh38.p13	chr5	122077670	122077670	+	T	T	G	Missense_Mutation	SNP	ENST00000231004.5	exon1	c.A316C	p.T106P	exonic	ENSG00000113083.14	.	nonsynonymous SNV	ENSG00000113083.14:ENST00000231004.5:exon1:c.A316C:p.T106P	5q23.1	C3L-03356	0.0001	0	0	0	0	2.516e-05	0	0.0008	rs575026013	2.20	T	T	B	B	N	N	N	T	N	0.051	T	T	D	0.016	0.187	0.182	0.692	D	T	T	T	T	T	0.769	9.092	0.319	N	N	-1.212	0.219	-1.288	0.217	1.000	0.455	0.609	0.504	0.562	.	3.530	-2.320	-1.246	-0.042	0.557	0.000	0.002	0.013	690	.	.	.	.	LOX	155	1	478	36	0.0700389105058366	TRUE	NA
ENSG00000145861.9	.	BCM	GRCh38.p13	chr5	160354915	160354915	+	G	G	A	Nonsense_Mutation	SNP	ENST00000652664.2	exon2	c.C97T	p.Q33X	exonic	ENSG00000145861.9	.	stopgain	ENSG00000145861.9:ENST00000652664.2:exon2:c.C97T:p.Q33X	5q33.3	C3L-03356	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.285	.	.	.	.	.	.	.	.	.	D	D	.	.	7.413	38	0.998	D	N	0.790	8.596	0.641	6.779	0.998	0.615	0.574	0.659	0.586	.	5.010	4.040	7.802	1.176	0.618	1.000	0.994	0.813	934	.	.	.	.	C1QTNF2	154	0	406	38	0.0855855855855856	TRUE	TRUE
ENSG00000204704.2	.	BCM	GRCh38.p13	chr6	29044472	29044472	+	C	C	T	Missense_Mutation	SNP	ENST00000377175.1	exon1	c.G704A	p.R235Q	exonic	ENSG00000204704.2	.	nonsynonymous SNV	ENSG00000204704.2:ENST00000377175.1:exon1:c.G704A:p.R235Q	6p22.1	C3L-03356	.	.	.	.	.	.	.	.	rs896592244	0.19	T	T	B	B	N	N	N	T	N	0.015	T	T	T	0.037	.	0.030	0.092	T	T	T	T	T	.	0.016	1.436	0.644	N	N	-1.442	0.101	-1.445	0.130	0.001	0.487	0.574	0.574	0.564	.	4.790	-0.435	-3.378	-0.857	-0.976	0.000	0.000	0.137	749	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV65851468;OCCURENCE=5(skin)	OR2W1	135	1	264	17	0.0604982206405694	TRUE	TRUE
ENSG00000164418.20	.	BCM	GRCh38.p13	chr6	101799762	101799762	+	G	G	A	Missense_Mutation	SNP	ENST00000421544.6	exon10	c.G1066A	p.G356R	exonic	ENSG00000164418.20	.	nonsynonymous SNV	ENSG00000164418.20:ENST00000421544.6:exon10:c.G1066A:p.G356R	6q16.3	C3L-03356	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.983	D	D	D	0.952	0.941	0.969	1.160	D	D	D	D	D	D	4.228	28.900	0.999	D	D	1.007	14.138	0.937	15.444	1.000	0.554	0.624	0.602	0.564	.	5.300	5.300	9.602	1.176	0.676	1.000	0.906	0.988	700	Receptor,_ligand_binding_region	.	.	ID=COSV59736816;OCCURENCE=1(large_intestine)	GRIK2	176	0	382	28	0.0682926829268293	TRUE	TRUE
ENSG00000146350.14	.	BCM	GRCh38.p13	chr6	121279241	121279241	+	G	G	A	Missense_Mutation	SNP	ENST00000398212.7	exon15	c.C1613T	p.S538F	exonic	ENSG00000146350.14	.	nonsynonymous SNV	ENSG00000146350.14:ENST00000398212.7:exon15:c.C1613T:p.S538F	6q22.31	C3L-03356	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	N	T	N	0.103	T	T	T	0.026	0.250	0.178	0.040	.	T	T	T	T	T	1.839	18.020	0.768	D	N	-0.413	1.355	-0.274	1.618	0.000	0.554	0.588	0.602	0.621	.	5.490	2.770	1.404	0.227	0.618	0.977	0.998	0.961	766	.	.	.	.	TBC1D32	179	0	360	34	0.0862944162436548	TRUE	TRUE
ENSG00000153956.16	.	BCM	GRCh38.p13	chr7	82349643	82349643	+	T	T	A	Missense_Mutation	SNP	ENST00000356253.9	exon2	c.A102T	p.K34N	exonic	ENSG00000153956.16	.	nonsynonymous SNV	ENSG00000153956.16:ENST00000356253.9:exon2:c.A102T:p.K34N	7q21.11	C3L-03356	.	.	.	.	.	.	.	.	.	8.20	T	D	B	B	D	D	M	T	N	0.614	T	T	T	0.095	0.462	0.162	1.922	D	T	T	T	D	D	2.205	20.900	0.998	D	N	-0.163	1.983	-0.048	2.203	0.984	0.638	0.574	0.653	0.668	.	6.010	3.110	0.300	-0.272	-0.915	0.997	0.997	0.987	939	.	.	.	ID=COSV62388142;OCCURENCE=1(large_intestine)	CACNA2D1	259	0	582	39	0.0628019323671498	TRUE	TRUE
ENSG00000186472.20	.	BCM	GRCh38.p13	chr7	82760776	82760776	+	C	C	G	Missense_Mutation	SNP	ENST00000333891.14	exon24	c.G15151C	p.V5051L	exonic	ENSG00000186472.20	.	nonsynonymous SNV	ENSG00000186472.20:ENST00000333891.14:exon24:c.G15151C:p.V5051L	7q21.11	C3L-03356	.	.	.	.	.	.	.	.	.	10.16	D	D	.	.	U	D	.	T	N	0.726	T	T	D	0.373	0.633	0.522	0.036	D	.	D	T	D	D	3.794	25.800	0.949	D	D	0.919	11.551	0.844	11.568	1.000	0.554	0.588	0.476	0.586	.	5.050	5.050	7.905	1.026	0.549	1.000	0.997	0.999	865	C2_domain	.	.	.	PCLO	44	0	95	7	0.0686274509803922	TRUE	TRUE
ENSG00000136929.13	.	BCM	GRCh38.p13	chr9	97930187	97930187	+	G	G	A	Missense_Mutation	SNP	ENST00000616898.2	exon3	c.C1208T	p.P403L	exonic	ENSG00000136929.13	.	nonsynonymous SNV	ENSG00000136929.13:ENST00000616898.2:exon3:c.C1208T:p.P403L	9q22.33	C3L-03356	4.118e-05	0	8.637e-05	0	0	5.993e-05	0	0	rs777811108	3.19	D	D	B	B	N	N	L	.	D	0.055	T	T	T	0.028	0.203	0.196	0.054	T	T	T	T	T	T	0.285	4.119	0.873	N	N	-1.145	0.269	-1.217	0.269	1.000	0.497	0.547	0.590	0.530	.	4.510	0.183	0.299	-1.387	-0.904	0.039	0.000	0.004	605	.	.	.	.	HEMGN	457	0	958	72	0.0699029126213592	TRUE	NA
ENSG00000188162.11	.	BCM	GRCh38.p13	chr11	17569207	17569207	+	C	C	T	Missense_Mutation	SNP	ENST00000399391.7	exon15	c.C1732T	p.P578S	exonic	ENSG00000188162.11	.	nonsynonymous SNV	ENSG00000188162.11:ENST00000399391.7:exon15:c.C1732T:p.P578S	11p15.1	C3L-03356	.	.	.	.	.	.	.	.	.	3.18	T	T	.	.	U	D	N	T	N	0.151	T	T	T	0.071	0.514	0.270	.	T	T	T	T	D	T	2.760	22.900	0.998	D	N	0.096	2.870	0.214	3.252	0.656	0.554	0.547	0.602	0.564	.	5.380	5.380	2.250	1.026	0.599	1.000	1.000	0.996	812	von_Willebrand_factor,_type_D_domain	.	.	.	OTOG	280	0	605	39	0.0605590062111801	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-03356	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	257	2	477	45	0.0862068965517241	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675224	7675224	+	G	G	C	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.C388G	p.L130V	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.C388G:p.L130V	17p13.1	C3L-03356	.	.	.	.	.	.	.	.	rs863224683	19.20	D	D	D	D	D	D	M	D	D	0.791	D	D	D	0.887	0.920	0.993	1.665	T	D	D	D	D	D	3.677	25.300	0.998	D	D	0.798	8.739	0.745	8.693	1.000	0.722	0.702	0.698	0.735	.	5.480	5.480	5.793	1.176	0.676	1.000	0.855	0.961	434	p53,_DNA-binding_domain	.	.	ID=COSV52692226;OCCURENCE=5(breast),2(liver),2(oesophagus),7(large_intestine),1(central_nervous_system),3(ovary),2(stomach),6(haematopoietic_and_lymphoid_tissue),2(pancreas),2(lung),2(upper_aerodigestive_tract)	TP53	217	0	479	45	0.0858778625954199	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11690172	11690172	+	G	G	T	Missense_Mutation	SNP	ENST00000262442.9	exon20	c.G4350T	p.Q1450H	exonic	ENSG00000007174.18	.	nonsynonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon20:c.G4350T:p.Q1450H	17p12	C3L-03356	.	.	.	.	.	.	.	.	.	4.19	D	.	B	B	D	D	L	T	N	0.423	T	T	T	0.083	0.780	0.515	0.085	T	T	T	T	T	T	1.739	17.300	0.973	D	N	-0.627	0.939	-0.494	1.211	0.000	0.487	0.574	0.574	0.564	.	5.570	-0.501	0.217	0.198	-0.153	0.761	0.996	0.972	883	Dynein_heavy_chain,_domain-2	.	.	.	DNAH9	322	1	712	68	0.0871794871794872	TRUE	TRUE
ENSG00000141200.8	.	BCM	GRCh38.p13	chr17	53823115	53823115	+	G	G	C	Missense_Mutation	SNP	ENST00000268919.6	exon1	c.G82C	p.E28Q	exonic	ENSG00000141200.8	.	nonsynonymous SNV	ENSG00000141200.8:ENST00000268919.6:exon1:c.G82C:p.E28Q	17q22	C3L-03356	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.082	T	T	T	0.099	0.318	0.574	0.096	T	T	T	T	T	D	1.599	16.360	0.865	N	N	-0.887	0.537	-0.863	0.671	0.000	0.487	0.574	0.547	0.564	.	4.960	1.870	1.031	1.176	0.676	0.004	0.059	0.057	895	.	.	.	.	KIF2B	237	0	582	39	0.0628019323671498	TRUE	TRUE
ENSG00000170929.6	.	BCM	GRCh38.p13	chr19	9094073	9094073	+	A	A	T	Missense_Mutation	SNP	ENST00000641627.1	exon2	c.A829T	p.M277L	exonic	ENSG00000170929.6	.	nonsynonymous SNV	ENSG00000170929.6:ENST00000641627.1:exon2:c.A829T:p.M277L	19p13.2	C3L-03356	.	.	.	.	.	.	.	.	.	2.20	T	T	P	P	D	N	N	T	N	0.165	T	T	T	0.080	0.565	0.257	0.177	T	T	T	T	D	T	2.195	20.800	0.962	N	N	-0.180	1.932	-0.287	1.591	0.000	0.487	0.574	0.574	0.564	.	3.710	2.670	-1.407	0.930	-0.102	0.000	0.235	0.069	970	GPCR,_rhodopsin-like,_7TM	.	.	.	OR1M1	311	0	531	36	0.0634920634920635	TRUE	NA
ENSG00000008441.16	.	BCM	GRCh38.p13	chr19	13025189	13025189	+	G	G	A	Missense_Mutation	SNP	ENST00000592199.5	exon2	c.G196A	p.E66K	exonic	ENSG00000008441.16	.	nonsynonymous SNV	ENSG00000008441.16:ENST00000592199.5:exon2:c.G196A:p.E66K	19p13.13	C3L-03356	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.914	T	T	D	0.543	0.603	0.901	2.649	D	D	D	D	D	D	4.590	32	0.999	D	D	0.883	10.630	0.862	12.226	1.000	0.767	0.627	0.666	0.555	.	5.260	5.260	9.942	1.161	0.676	1.000	0.999	0.998	470	CTF_transcription_factor/nuclear_factor_1,_DNA-binding_domain	.	.	.	NFIX	442	0	1183	95	0.0743348982785603	TRUE	TRUE
ENSG00000197841.15	.	BCM	GRCh38.p13	chr19	34741197	34741197	+	G	G	C	Missense_Mutation	SNP	ENST00000492450.3	exon4	c.G816C	p.K272N	exonic	ENSG00000197841.15	.	nonsynonymous SNV	ENSG00000197841.15:ENST00000492450.3:exon4:c.G816C:p.K272N	19q13.11	C3L-03356	.	.	.	.	.	.	.	.	.	5.19	D	D	P	B	.	N	M	T	D	0.496	T	T	T	0.075	0.563	0.550	0.554	T	T	T	T	D	T	2.686	22.800	0.999	N	N	0.024	2.597	-0.076	2.118	0.000	0.732	0.654	0.744	0.636	.	2.890	2.890	0.553	0.993	0.604	0.189	0.988	0.992	382	Zinc_finger_C2H2-type;Zinc_finger,_BED-type	.	.	.	ZNF181	208	0	506	29	0.0542056074766355	NA	TRUE
ENSG00000125503.13	.	BCM	GRCh38.p13	chr19	55117387	55117387	+	C	C	T	Missense_Mutation	SNP	ENST00000263433.8	exon1	c.G157A	p.A53T	exonic	ENSG00000125503.13	.	nonsynonymous SNV	ENSG00000125503.13:ENST00000263433.8:exon1:c.G157A:p.A53T	19q13.42	C3L-03356	.	.	.	.	.	.	.	.	.	9.20	D	D	D	B	U	D	L	T	D	0.340	T	T	D	0.180	0.221	0.811	0.326	D	T	T	T	T	D	3.030	23.500	0.999	D	N	0.099	2.884	0.079	2.649	1.000	0.767	0.219	0.851	0.492	.	2.490	2.490	1.182	0.820	0.377	0.675	0.996	0.980	988	.	.	.	.	PPP1R12C	15	0	34	3	0.0810810810810811	TRUE	NA
ENSG00000088836.14	.	BCM	GRCh38.p13	chr20	3231532	3231532	+	G	G	A	Missense_Mutation	SNP	ENST00000380056.7	exon7	c.C794T	p.A265V	exonic	ENSG00000088836.14	.	nonsynonymous SNV	ENSG00000088836.14:ENST00000380056.7:exon7:c.C794T:p.A265V	20p13	C3L-03356	2.479e-05	0	8.654e-05	0.0001	0	1.505e-05	0	0	rs771135532	17.20	D	D	D	D	D	D	M	T	D	0.528	D	D	D	0.610	0.690	0.948	0.615	T	T	D	D	D	D	3.149	23.700	0.999	D	D	0.496	5.006	0.362	4.102	1.000	0.706	0.588	0.723	0.613	.	5.080	5.080	8.041	1.079	0.672	1.000	0.276	0.498	452	.	.	.	ID=COSV66261411;OCCURENCE=1(oesophagus),1(large_intestine),1(stomach)	SLC4A11	248	0	628	44	0.0654761904761905	TRUE	TRUE
ENSG00000160299.17	.	BCM	GRCh38.p13	chr21	46363849	46363849	+	G	G	C	Missense_Mutation	SNP	ENST00000359568.10	exon14	c.G2524C	p.E842Q	exonic	ENSG00000160299.17	.	nonsynonymous SNV	ENSG00000160299.17:ENST00000359568.10:exon14:c.G2524C:p.E842Q	21q22.3	C3L-03356	.	.	.	.	.	.	.	.	.	7.20	D	D	D	D	N	N	M	T	N	0.256	T	T	T	0.094	0.068	0.558	0.322	T	T	T	T	D	T	3.252	24.000	0.996	D	N	0.131	3.012	0.067	2.605	0.643	0.719	0.654	0.723	0.636	.	4.430	3.520	4.168	0.999	0.526	0.989	0.865	0.083	976	.	.	.	ID=COSV64025049;OCCURENCE=1(salivary_gland),1(urinary_tract),3(lung),1(upper_aerodigestive_tract)	PCNT	102	0	188	30	0.137614678899083	TRUE	TRUE
ENSG00000102302.8	.	BCM	GRCh38.p13	chrX	54455714	54455714	+	C	C	T	Missense_Mutation	SNP	ENST00000375135.4	exon11	c.G1913A	p.R638H	exonic	ENSG00000102302.8	.	nonsynonymous SNV	ENSG00000102302.8:ENST00000375135.4:exon11:c.G1913A:p.R638H	Xp11.22	C3L-03356	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	N	D	M	T	D	0.332	D	D	D	0.568	0.622	0.886	2.483	T	D	D	T	T	D	3.769	25.700	1.000	D	.	.	.	.	.	1.000	.	.	.	.	.	5.080	5.080	4.107	1.011	0.581	0.469	1.000	0.999	351	Pleckstrin_homology_domain;FGD1,_N-terminal_PH_domain	.	.	.	FGD1	170	0	354	60	0.144927536231884	TRUE	NA
ENSG00000140107.12	.	BCM	GRCh38.p13	chr14	100329441	100329441	+	C	C	A	Silent	SNP	ENST00000361529.5	exon6	c.C723A	p.I241I	exonic	ENSG00000140107.12	.	synonymous SNV	ENSG00000140107.12:ENST00000361529.5:exon6:c.C723A:p.I241I	14q32.2	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC25A47	216	0	560	48	0.0789473684210526	TRUE	TRUE
ENSG00000141200.8	.	BCM	GRCh38.p13	chr17	53823432	53823432	+	G	G	A	Silent	SNP	ENST00000268919.6	exon1	c.G399A	p.V133V	exonic	ENSG00000141200.8	.	synonymous SNV	ENSG00000141200.8:ENST00000268919.6:exon1:c.G399A:p.V133V	17q22	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIF2B	176	1	410	29	0.0660592255125285	TRUE	TRUE
ENSG00000141200.8	.	BCM	GRCh38.p13	chr17	53823456	53823456	+	G	G	A	Silent	SNP	ENST00000268919.6	exon1	c.G423A	p.L141L	exonic	ENSG00000141200.8	.	synonymous SNV	ENSG00000141200.8:ENST00000268919.6:exon1:c.G423A:p.L141L	17q22	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIF2B	139	0	345	23	0.0625	TRUE	TRUE
ENSG00000187775.17	.	BCM	GRCh38.p13	chr17	78479037	78479037	+	G	G	A	Silent	SNP	ENST00000389840.7	exon51	c.C7980T	p.S2660S	exonic	ENSG00000187775.17	.	synonymous SNV	ENSG00000187775.17:ENST00000389840.7:exon51:c.C7980T:p.S2660S	17q25.3	C3L-03356	8.491e-06	0.0001	0	0	0	0	0	0	rs574957481	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH17	133	0	256	19	0.0690909090909091	TRUE	NA
ENSG00000134490.14	.	BCM	GRCh38.p13	chr18	23373760	23373760	+	G	G	T	Silent	SNP	ENST00000383233.8	exon7	c.C387A	p.A129A	exonic	ENSG00000134490.14	.	synonymous SNV	ENSG00000134490.14:ENST00000383233.8:exon7:c.C387A:p.A129A	18q11.2	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM241	116	1	297	21	0.0660377358490566	TRUE	TRUE
ENSG00000198796.7	.	BCM	GRCh38.p13	chr18	58536557	58536557	+	G	G	A	Silent	SNP	ENST00000361673.4	exon5	c.C3630T	p.N1210N	exonic	ENSG00000198796.7	.	synonymous SNV	ENSG00000198796.7:ENST00000361673.4:exon5:c.C3630T:p.N1210N	18q21.31	C3L-03356	4.12e-05	0.0003	0	0	0	1.499e-05	0	6.058e-05	rs371254825	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100864778;OCCURENCE=1(breast)	ALPK2	101	0	234	15	0.0602409638554217	TRUE	NA
ENSG00000196081.10	.	BCM	GRCh38.p13	chr19	23222406	23222406	+	A	A	T	Silent	SNP	ENST00000418100.6	exon4	c.T1839A	p.A613A	exonic	ENSG00000196081.10	.	synonymous SNV	ENSG00000196081.10:ENST00000418100.6:exon4:c.T1839A:p.A613A	19p12	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF724	103	0	225	20	0.0816326530612245	TRUE	TRUE
ENSG00000163702.20	.	BCM	GRCh38.p13	chr3	9932899	9932899	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000163702.20;ENSG00000288550.1	.	.	.	3p25.3	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IL17RC	84	0	244	186	0.432558139534884	TRUE	NA
ENSG00000236939.2	.	BCM	GRCh38.p13	chr8	103133109	103133109	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000236939.2	.	.	.	8q22.3	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BAALC-AS2	270	0	697	61	0.0804749340369393	TRUE	NA
ENSG00000280287.1	.	BCM	GRCh38.p13	chr12	132551335	132551335	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000280287.1	.	.	.	12q24.33	C3L-03356	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC131212.3	77	0	219	19	0.0798319327731092	TRUE	NA
ENSG00000163399.16	.	BCM	GRCh38.p13	chr1	116390297	116390297	+	A	A	T	Missense_Mutation	SNP	ENST00000295598.10	exon9	c.A1108T	p.T370S	exonic	ENSG00000163399.16	.	nonsynonymous SNV	ENSG00000163399.16:ENST00000295598.10:exon9:c.A1108T:p.T370S	1p13.1	C3N-02944	.	.	.	.	.	.	.	.	.	16.20	D	D	B	P	D	D	M	T	D	0.753	D	D	D	0.855	0.750	0.954	1.545	T	D	D	D	D	D	3.207	23.900	0.995	D	D	0.517	5.168	0.555	5.699	1.000	0.731	0.750	0.702	0.711	.	4.870	4.870	9.325	1.312	0.756	1.000	0.998	0.993	702	.	.	.	.	ATP1A1	365	0	326	23	0.0659025787965616	TRUE	TRUE
ENSG00000134249.7	.	BCM	GRCh38.p13	chr1	119896302	119896302	+	C	C	T	Missense_Mutation	SNP	ENST00000369400.2	exon1	c.G35A	p.R12H	exonic	ENSG00000134249.7	.	nonsynonymous SNV	ENSG00000134249.7:ENST00000369400.2:exon1:c.G35A:p.R12H	1p12	C3N-02944	.	.	.	.	.	.	.	.	.	1.20	D	T	B	B	N	N	N	T	N	0.053	T	T	T	0.111	0.634	0.168	0.134	T	T	T	T	T	T	-0.412	0.181	0.960	N	N	-1.208	0.221	-1.310	0.202	1.000	0.598	0.563	0.600	0.639	.	4.450	-4.510	-2.494	-0.447	0.524	0.000	0.000	0.003	859	.	.	.	.	ADAM30	47	0	27	4	0.129032258064516	TRUE	TRUE
ENSG00000239305.7	.	BCM	GRCh38.p13	chr2	86622677	86622677	+	C	C	G	Missense_Mutation	SNP	ENST00000237455.5	exon1	c.G210C	p.E70D	exonic	ENSG00000239305.7	.	nonsynonymous SNV	ENSG00000239305.7:ENST00000237455.5:exon1:c.G210C:p.E70D	2p11.2	C3N-02944	.	.	.	.	.	.	.	.	.	5.20	T	D	B	B	D	D	N	T	N	0.278	T	T	D	0.170	0.149	0.752	0.186	D	T	T	T	T	T	2.301	21.600	0.945	N	N	-0.390	1.406	-0.243	1.687	1.000	0.628	0.672	0.619	0.562	.	4.180	3.270	0.892	0.962	0.524	1.000	1.000	0.997	587	.	.	.	.	RNF103	379	0	301	23	0.0709876543209877	TRUE	TRUE
ENSG00000115850.10	.	BCM	GRCh38.p13	chr2	135809940	135809940	+	C	C	G	Missense_Mutation	SNP	ENST00000264162.7	exon8	c.G2407C	p.D803H	exonic	ENSG00000115850.10	.	nonsynonymous SNV	ENSG00000115850.10:ENST00000264162.7:exon8:c.G2407C:p.D803H	2q21.3	C3N-02944	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.931	D	D	D	0.844	0.905	0.940	1.763	T	D	D	D	D	D	3.773	25.700	0.995	D	D	1.063	16.027	0.946	15.868	1.000	0.487	0.547	0.574	0.542	.	5.710	5.710	7.852	1.022	0.596	1.000	0.990	0.913	240	.	.	.	.	LCT	194	0	145	9	0.0584415584415584	TRUE	TRUE
ENSG00000144290.17	.	BCM	GRCh38.p13	chr2	161904125	161904125	+	T	T	C	Missense_Mutation	SNP	ENST00000446997.6	exon13	c.T1564C	p.S522P	exonic	ENSG00000144290.17	.	nonsynonymous SNV	ENSG00000144290.17:ENST00000446997.6:exon13:c.T1564C:p.S522P	2q24.2	C3N-02944	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.868	D	D	D	0.925	0.772	0.942	1.397	D	D	D	D	D	D	4.173	28.400	0.999	D	D	0.919	11.558	0.846	11.622	1.000	0.554	0.574	0.618	0.613	.	5.410	5.410	8.017	1.138	0.665	1.000	1.000	1.000	641	Bicarbonate_transporter,_C-terminal	.	.	.	SLC4A10	205	0	175	17	0.0885416666666667	TRUE	TRUE
ENSG00000181744.9	.	BCM	GRCh38.p13	chr3	143985724	143985724	+	A	A	C	Missense_Mutation	SNP	ENST00000315691.8	exon2	c.A839C	p.E280A	exonic	ENSG00000181744.9	.	nonsynonymous SNV	ENSG00000181744.9:ENST00000315691.8:exon2:c.A839C:p.E280A	3q24	C3N-02944	.	.	.	.	.	.	.	.	.	9.15	D	D	.	.	D	D	.	T	D	0.512	T	T	T	0.257	0.430	0.442	0.897	.	.	T	T	D	D	2.904	23.200	0.992	D	D	0.183	3.227	0.334	3.920	1.000	0.732	0.744	0.644	0.714	.	5.120	5.120	8.947	1.312	0.756	1.000	1.000	0.998	940	FAM69,_protein-kinase_domain	.	.	.	DIPK2A	297	0	197	15	0.0707547169811321	TRUE	TRUE
ENSG00000156194.18	.	BCM	GRCh38.p13	chr4	75866206	75866206	+	C	C	T	Missense_Mutation	SNP	ENST00000286719.12	exon15	c.G1903A	p.E635K	exonic	ENSG00000156194.18	.	nonsynonymous SNV	ENSG00000156194.18:ENST00000286719.12:exon15:c.G1903A:p.E635K	4q21.1	C3N-02944	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	U	N	N	T	N	0.201	T	T	T	0.033	0.370	0.462	0.169	T	T	T	T	T	T	1.082	12.590	0.983	D	N	-0.712	0.793	-0.610	1.031	0.258	0.487	0.563	0.574	0.530	.	4.670	2.850	1.609	0.102	-0.230	0.666	0.316	0.272	902	.	.	.	ID=COSV54422600;OCCURENCE=1(skin)	PPEF2	68	0	57	15	0.208333333333333	TRUE	TRUE
ENSG00000092421.16	.	BCM	GRCh38.p13	chr5	116486965	116486965	+	A	A	G	Missense_Mutation	SNP	ENST00000257414.12	exon10	c.T746C	p.V249A	exonic	ENSG00000092421.16	.	nonsynonymous SNV	ENSG00000092421.16:ENST00000257414.12:exon10:c.T746C:p.V249A	5q23.1	C3N-02944	.	.	.	.	.	.	.	.	.	7.17	T	T	.	.	D	D	.	T	N	0.575	T	T	T	0.295	0.452	0.329	0.854	D	T	D	T	D	T	2.891	23.200	0.998	D	D	0.481	4.892	0.525	5.391	1.000	0.672	0.634	0.702	0.621	.	5.900	5.900	7.509	1.312	0.756	1.000	0.995	0.944	980	Sema_domain	.	.	.	SEMA6A	184	0	130	8	0.0579710144927536	TRUE	TRUE
ENSG00000120318.16	.	BCM	GRCh38.p13	chr5	141655385	141655385	+	G	G	A	Missense_Mutation	SNP	ENST00000239440.9	exon32	c.C4126T	p.R1376W	exonic	ENSG00000120318.16	.	nonsynonymous SNV	ENSG00000120318.16:ENST00000239440.9:exon32:c.C4126T:p.R1376W	5q31.3	C3N-02944	0.0001	0	0	0	0.0011	0.0002	0	0	rs141682206	13.20	D	D	D	D	D	D	M	T	D	0.882	T	T	D	0.220	.	0.427	1.055	T	T	T	T	D	D	4.411	31	0.999	D	D	0.579	5.720	0.588	6.072	1.000	0.737	0.590	0.733	0.714	.	5.120	5.120	2.825	1.176	0.676	1.000	1.000	0.998	771	.	.	.	.	ARAP3	129	0	86	5	0.0549450549450549	TRUE	NA
ENSG00000196422.11	.	BCM	GRCh38.p13	chr9	135486347	135486347	+	G	G	A	Missense_Mutation	SNP	ENST00000356818.7	exon4	c.G1837A	p.V613M	exonic	ENSG00000196422.11	.	nonsynonymous SNV	ENSG00000196422.11:ENST00000356818.7:exon4:c.G1837A:p.V613M	9q34.3	C3N-02944	8.436e-06	0.0001	0	0	0	0	0	0	rs756198560	0.20	T	T	B	B	N	N	L	T	N	0.028	T	T	T	0.021	.	0.223	0.627	T	T	T	T	T	T	-0.256	0.387	0.993	N	N	-1.087	0.318	-1.184	0.296	1.000	0.672	0.588	0.702	0.636	.	5.310	-4.750	-1.139	0.079	-0.103	0.000	0.005	0.016	511	Protein_phosphatase_1_regulatory_subunit_26,_N-terminal_domain	.	.	.	PPP1R26	298	0	253	18	0.0664206642066421	TRUE	NA
ENSG00000151150.22	.	BCM	GRCh38.p13	chr10	60134318	60134318	+	G	G	A	Missense_Mutation	SNP	ENST00000280772.7	exon25	c.C2794T	p.R932W	exonic	ENSG00000151150.22	.	nonsynonymous SNV	ENSG00000151150.22:ENST00000280772.7:exon25:c.C2794T:p.R932W	10q21.2	C3N-02944	8.288e-06	0	0	0	0	1.505e-05	0	0	rs771103668	18.20	D	D	D	D	N	D	M	T	D	0.920	D	D	D	0.387	0.431	0.864	1.601	D	D	D	D	D	D	4.106	27.800	0.999	D	D	0.634	6.286	0.600	6.229	1.000	0.635	0.547	0.644	0.655	.	6.070	5.170	3.039	0.161	0.676	1.000	0.997	0.998	840	.	.	.	.	ANK3	209	0	159	9	0.0535714285714286	TRUE	NA
ENSG00000171813.14	.	BCM	GRCh38.p13	chr10	132405597	132405597	+	C	C	T	Missense_Mutation	SNP	ENST00000305233.6	exon2	c.C1097T	p.P366L	exonic	ENSG00000171813.14	.	nonsynonymous SNV	ENSG00000171813.14:ENST00000305233.6:exon2:c.C1097T:p.P366L	10q26.3	C3N-02944	8.043e-05	0.0001	8.862e-05	0.0001	0	9.912e-05	0	0	rs200265938	2.20	T	T	B	B	U	N	L	T	D	0.204	T	T	D	0.080	.	0.093	0.804	T	T	T	T	T	T	1.612	16.450	0.988	N	N	-0.639	0.918	-0.624	1.011	1.000	0.840	0.588	0.737	0.636	.	4.060	4.060	2.350	0.768	-0.200	0.015	0.003	0.001	994	.	.	.	.	PWWP2B	312	0	283	20	0.066006600660066	TRUE	NA
ENSG00000130037.5	.	BCM	GRCh38.p13	chr12	5045024	5045024	+	G	G	A	Missense_Mutation	SNP	ENST00000252321.5	exon1	c.G877A	p.A293T	exonic	ENSG00000130037.5	.	nonsynonymous SNV	ENSG00000130037.5:ENST00000252321.5:exon1:c.G877A:p.A293T	12p13.32	C3N-02944	.	.	.	.	.	.	.	.	rs898525645	3.20	T	T	B	B	N	N	N	D	N	0.131	T	D	D	0.288	0.335	0.998	0.509	T	T	T	T	T	T	1.315	14.490	0.827	N	N	-0.890	0.533	-0.781	0.784	0.152	0.598	0.563	0.596	0.542	.	4.770	3.850	2.967	1.089	0.575	0.166	0.001	0.004	680	Ion_transport_domain	.	.	ID=COSV52905174;OCCURENCE=1(stomach),1(thyroid),1(upper_aerodigestive_tract)	KCNA5	245	1	212	19	0.0822510822510823	TRUE	TRUE
ENSG00000111732.11	.	BCM	GRCh38.p13	chr12	8605482	8605482	+	C	C	T	Missense_Mutation	SNP	ENST00000229335.11	exon3	c.G160A	p.G54S	exonic	ENSG00000111732.11	.	nonsynonymous SNV	ENSG00000111732.11:ENST00000229335.11:exon3:c.G160A:p.G54S	12p13.31	C3N-02944	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	D	D	M	T	D	0.635	T	T	D	0.379	0.532	0.880	1.866	T	T	T	T	D	D	3.613	25.100	0.997	D	D	0.273	3.641	0.141	2.908	0.858	0.672	0.702	0.578	0.530	.	5.190	4.290	4.783	1.026	0.599	0.997	0.080	0.199	927	APOBEC-like,_N-terminal;Cytidine_and_deoxycytidylate_deaminase_domain	.	.	ID=COSV57563615;OCCURENCE=1(salivary_gland),1(skin)	AICDA	360	0	283	26	0.0841423948220065	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-02944	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	265	0	229	20	0.0803212851405622	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674935	7674935	+	C	C	A	Missense_Mutation	SNP	ENST00000269305.8	exon6	c.G596T	p.G199V	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon6:c.G596T:p.G199V	17p13.1	C3N-02944	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.960	D	D	D	0.899	0.901	0.965	1.857	T	D	D	D	D	T	4.050	27.400	0.997	D	D	0.766	8.152	0.661	7.077	1.000	0.722	0.698	0.702	0.735	.	5.280	5.280	7.905	1.015	0.599	1.000	0.844	0.981	433	p53,_DNA-binding_domain	.	.	ID=COSV52679535;OCCURENCE=5(breast),1(liver),11(large_intestine),2(central_nervous_system),1(biliary_tract),2(ovary),1(stomach),1(urinary_tract),1(skin),3(prostate),2(upper_aerodigestive_tract)	TP53	492	0	330	26	0.0730337078651685	TRUE	TRUE
ENSG00000187912.12	.	BCM	GRCh38.p13	chr19	14610087	14610087	+	A	A	G	Missense_Mutation	SNP	ENST00000417570.6	exon14	c.A1028G	p.N343S	exonic	ENSG00000187912.12	.	nonsynonymous SNV	ENSG00000187912.12:ENST00000417570.6:exon14:c.A1028G:p.N343S	19p13.12	C3N-02944	.	.	.	.	.	.	.	.	.	8.19	D	D	D	D	.	D	L	T	D	0.448	T	T	T	0.156	0.380	0.507	0.454	T	T	T	T	D	T	3.102	23.600	0.998	D	N	0.464	4.771	0.350	4.021	0.700	0.672	0.702	0.574	0.564	.	3.880	3.880	3.588	1.092	0.756	1.000	0.945	0.498	958	C-type_lectin-like;CD209-like,_C-type_lectin-like_domain	.	.	.	CLEC17A	149	0	119	13	0.0984848484848485	TRUE	TRUE
ENSG00000105755.8	.	BCM	GRCh38.p13	chr19	43511560	43511560	+	C	C	G	Missense_Mutation	SNP	ENST00000292147.7	exon4	c.G382C	p.E128Q	exonic	ENSG00000105755.8	.	nonsynonymous SNV	ENSG00000105755.8:ENST00000292147.7:exon4:c.G382C:p.E128Q	19q13.31	C3N-02944	.	.	.	.	.	.	.	.	.	11.20	T	T	P	B	N	D	L	D	N	0.379	D	D	D	0.673	0.409	0.930	0.699	T	D	D	D	D	T	2.358	21.900	0.992	D	D	0.117	2.953	0.184	3.107	1.000	0.706	0.644	0.710	0.714	.	4.950	4.950	4.615	1.011	0.581	1.000	0.977	0.352	889	Metallo-beta-lactamase	.	.	.	ETHE1	286	0	239	18	0.0700389105058366	TRUE	TRUE
ENSG00000267467.4	.	BCM	GRCh38.p13	chr19	44945301	44945301	+	G	G	A	Missense_Mutation	SNP	ENST00000592954.2	exon3	c.G380A	p.G127D	exonic	ENSG00000267467.4	.	nonsynonymous SNV	ENSG00000267467.4:ENST00000592954.2:exon3:c.G380A:p.G127D	19q13.32	C3N-02944	1.692e-05	0	0	0	0	1.534e-05	0	6.434e-05	rs562108646	1.16	.	D	B	B	N	N	N	T	.	0.076	T	T	T	0.005	0.196	0.030	.	.	T	T	T	T	.	-0.214	0.476	0.976	N	N	-1.402	0.116	-1.446	0.130	1.000	0.428	0.547	0.547	0.613	.	3.520	-1.480	-0.805	-0.147	-0.105	0.000	0.048	0.228	873	.	.	.	.	APOC4	103	0	70	9	0.113924050632911	TRUE	NA
ENSG00000177380.14	.	BCM	GRCh38.p13	chr19	49133832	49133832	+	C	C	T	Missense_Mutation	SNP	ENST00000334186.9	exon10	c.C1198T	p.R400W	exonic	ENSG00000177380.14	.	nonsynonymous SNV	ENSG00000177380.14:ENST00000334186.9:exon10:c.C1198T:p.R400W	19q13.33	C3N-02944	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	U	D	M	T	D	0.735	T	T	D	0.253	0.315	0.547	2.678	T	T	D	T	D	D	4.157	28.300	0.999	D	D	0.343	4.007	0.242	3.396	1.000	0.652	0.525	0.641	0.619	.	4.010	1.560	1.106	0.947	0.599	0.953	0.997	0.985	631	.	.	.	ID=COSV61949585;OCCURENCE=1(urinary_tract),1(lung)	PPFIA3	305	0	246	14	0.0538461538461538	TRUE	TRUE
ENSG00000179709.8	.	BCM	GRCh38.p13	chr19	55954522	55954522	+	C	C	A	Nonsense_Mutation	SNP	ENST00000291971.7	exon3	c.C464A	p.S155X	exonic	ENSG00000179709.8	.	stopgain	ENSG00000179709.8:ENST00000291971.7:exon3:c.C464A:p.S155X	19q13.43	C3N-02944	.	.	.	.	.	.	.	.	.	1.5	.	.	.	.	.	A	.	.	.	0.068	.	.	.	.	.	.	.	.	.	T	T	.	.	3.782	25.800	0.864	N	N	-0.681	0.845	-1.110	0.366	0.000	0.487	0.574	0.547	0.564	.	1.770	-1.850	-1.403	-1.845	-1.094	0.000	0.000	0.000	946	.	.	.	.	NLRP8	133	0	115	13	0.1015625	TRUE	TRUE
ENSG00000101161.8	.	BCM	GRCh38.p13	chr20	63994991	63994991	+	C	C	T	Missense_Mutation	SNP	ENST00000266079.5	exon5	c.C514T	p.R172W	exonic	ENSG00000101161.8	.	nonsynonymous SNV	ENSG00000101161.8:ENST00000266079.5:exon5:c.C514T:p.R172W	20q13.33	C3N-02944	8.237e-06	0	0	0	0	1.499e-05	0	0	rs369787039	20.20	D	D	D	D	D	D	M	D	D	0.891	D	D	D	0.901	.	0.962	2.310	D	D	D	D	D	D	4.081	27.600	0.999	D	D	0.429	4.528	0.306	3.749	0.001	0.707	0.725	0.725	0.714	.	5.710	2.480	3.649	-0.251	-0.915	1.000	0.930	0.393	.	.	.	.	ID=COSV99411405;OCCURENCE=1(endometrium)	PRPF6	383	0	278	22	0.0733333333333333	TRUE	NA
ENSG00000154767.15	.	BCM	GRCh38.p13	chr3	14158542	14158542	+	G	G	A	Silent	SNP	ENST00000285021.12	exon9	c.C1341T	p.L447L	exonic	ENSG00000154767.15	.	synonymous SNV	ENSG00000154767.15:ENST00000285021.12:exon9:c.C1341T:p.L447L	3p25.1	C3N-02944	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	XPC	165	0	131	16	0.108843537414966	TRUE	TRUE
ENSG00000151150.22	.	BCM	GRCh38.p13	chr10	60070606	60070606	+	A	A	G	Silent	SNP	ENST00000280772.7	exon37	c.T10275C	p.D3425D	exonic	ENSG00000151150.22	.	synonymous SNV	ENSG00000151150.22:ENST00000280772.7:exon37:c.T10275C:p.D3425D	10q21.2	C3N-02944	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANK3	214	0	150	10	0.0625	TRUE	NA
ENSG00000134569.10	.	BCM	GRCh38.p13	chr11	46873461	46873461	+	C	C	T	Silent	SNP	ENST00000378623.6	exon29	c.G4362A	p.A1454A	exonic	ENSG00000134569.10	.	synonymous SNV	ENSG00000134569.10:ENST00000378623.6:exon29:c.G4362A:p.A1454A	11p11.2	C3N-02944	1.648e-05	0	0	0	0	0	0	0.0001	rs775166531	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRP4	595	0	566	34	0.0566666666666667	TRUE	NA
ENSG00000186660.15	.	BCM	GRCh38.p13	chr11	58579569	58579569	+	C	C	T	Silent	SNP	ENST00000316059.7	exon1	c.C288T	p.P96P	exonic	ENSG00000186660.15;ENSG00000255073.8	.	synonymous SNV	ENSG00000186660.15:ENST00000316059.7:exon1:c.C288T:p.P96P,ENSG00000255073.8:ENST00000389919.8:exon1:c.C288T:p.P96P	11q12.1	C3N-02944	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFP91	264	0	248	23	0.0848708487084871	TRUE	NA
ENSG00000180357.9	.	BCM	GRCh38.p13	chr15	64622994	64622994	+	C	C	T	Silent	SNP	ENST00000326648.4	exon2	c.C915T	p.P305P	exonic	ENSG00000180357.9	.	synonymous SNV	ENSG00000180357.9:ENST00000326648.4:exon2:c.C915T:p.P305P	15q22.31	C3N-02944	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF609	314	0	270	17	0.0592334494773519	TRUE	NA
ENSG00000005102.14	.	BCM	GRCh38.p13	chr17	43661361	43661361	+	C	C	T	Silent	SNP	ENST00000318579.9	exon1	c.G174A	p.A58A	exonic	ENSG00000005102.14	.	synonymous SNV	ENSG00000005102.14:ENST00000318579.9:exon1:c.G174A:p.A58A	17q21.31	C3N-02944	0.0001	0	0	0	0	7.557e-05	0	0.0006	rs373476200	2.14	D	T	.	.	.	D	.	.	N	0.062	T	T	T	0.098	.	0.236	.	.	T	T	T	T	T	-0.168	0.599	0.725	N	N	-1.313	0.158	-1.548	0.091	1.000	0.403	0.219	0.578	0.613	.	3.820	-7.640	-2.554	-1.092	-0.987	0.000	0.328	0.223	557	.	.	.	ID=COSV59355290;OCCURENCE=1(breast),1(large_intestine),1(endometrium)	MEOX1	118	0	80	5	0.0588235294117647	TRUE	NA
ENSG00000105278.12	.	BCM	GRCh38.p13	chr19	3827534	3827534	+	G	G	A	Silent	SNP	ENST00000262961.9	exon6	c.C972T	p.C324C	exonic	ENSG00000105278.12	.	synonymous SNV	ENSG00000105278.12:ENST00000262961.9:exon6:c.C972T:p.C324C	19p13.3	C3N-02944	9.963e-05	0	0	0	0	0.0001	0	0.0001	rs773842233	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99507699;OCCURENCE=1(cervix)	ZFR2	359	1	292	23	0.073015873015873	TRUE	NA
ENSG00000100354.21	.	BCM	GRCh38.p13	chr22	40265037	40265037	+	A	A	G	Silent	SNP	ENST00000454349.7	exon5	c.A807G	p.Q269Q	exonic	ENSG00000100354.21	.	synonymous SNV	ENSG00000100354.21:ENST00000454349.7:exon5:c.A807G:p.Q269Q	22q13.1	C3N-02944	0.0003	0.0001	0.0010	0	0.0006	0.0003	0.0011	0.0002	rs186669938	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100109279;OCCURENCE=1(prostate)	TNRC6B	122	0	83	9	0.0978260869565217	TRUE	NA
ENSG00000101204.17	.	BCM	GRCh38.p13	chr20	63343795	63343795	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000101204.17	ENST00000370263.9:c.*2943G>A	.	.	20q13.33	C3N-02944	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHRNA4	213	0	156	9	0.0545454545454545	TRUE	NA
ENSG00000183114.8	.	BCM	GRCh38.p13	chr1	20553440	20553440	+	C	C	T	Missense_Mutation	SNP	ENST00000332947.6	exon1	c.C467T	p.P156L	exonic	ENSG00000183114.8	.	nonsynonymous SNV	ENSG00000183114.8:ENST00000332947.6:exon1:c.C467T:p.P156L	1p36.12	C3N-00436	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	U	D	M	.	D	0.775	T	T	D	0.453	0.748	0.413	.	D	T	D	D	D	D	4.120	27.900	0.999	D	D	0.604	5.964	0.529	5.435	1.000	0.598	0.563	0.504	0.639	.	3.920	3.920	5.094	0.865	0.454	1.000	1.000	0.992	894	FAM43A/B,_phosphotyrosine-binding_domain;PTB/PI_domain	.	.	.	FAM43B	78	0	237	26	0.0988593155893536	TRUE	TRUE
ENSG00000142784.16	.	BCM	GRCh38.p13	chr1	27303737	27303737	+	C	C	T	Missense_Mutation	SNP	ENST00000319394.8	exon14	c.C1585T	p.R529C	exonic	ENSG00000142784.16	.	nonsynonymous SNV	ENSG00000142784.16:ENST00000319394.8:exon14:c.C1585T:p.R529C	1p36.11	C3N-00436	8.325e-06	0	0	0	0	1.519e-05	0	0	rs758639908	18.20	D	D	D	D	D	D	M	T	D	0.950	D	D	D	0.555	0.564	0.557	2.306	D	D	D	D	D	D	4.241	29.000	0.999	D	N	0.673	6.753	0.602	6.251	0.649	0.744	0.710	0.630	0.714	.	4.840	4.840	2.224	0.947	0.599	1.000	1.000	0.998	330	.	.	.	ID=COSV60087979;OCCURENCE=2(urinary_tract)	WDTC1	359	0	625	80	0.113475177304965	TRUE	TRUE
ENSG00000065243.20	.	BCM	GRCh38.p13	chr1	88833143	88833143	+	C	C	T	Missense_Mutation	SNP	ENST00000370521.8	exon21	c.C2737T	p.H913Y	exonic	ENSG00000065243.20	.	nonsynonymous SNV	ENSG00000065243.20:ENST00000370521.8:exon21:c.C2737T:p.H913Y	1p22.2	C3N-00436	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	U	D	M	T	N	0.631	D	T	D	0.503	0.803	0.696	1.342	T	T	D	D	D	D	3.931	26.500	0.998	D	D	0.938	12.066	0.881	12.968	1.000	0.706	0.725	0.710	0.714	.	5.620	5.620	5.802	1.026	0.549	1.000	1.000	0.996	880	Protein_kinase_domain	.	.	.	PKN2	269	0	464	36	0.072	TRUE	TRUE
ENSG00000136628.18	.	BCM	GRCh38.p13	chr1	219978686	219978686	+	G	G	A	Missense_Mutation	SNP	ENST00000366923.8	exon28	c.C3943T	p.L1315F	exonic	ENSG00000136628.18	.	nonsynonymous SNV	ENSG00000136628.18:ENST00000366923.8:exon28:c.C3943T:p.L1315F	1q41	C3N-00436	.	.	.	.	.	.	.	.	.	8.20	D	T	P	P	D	D	M	T	N	0.598	T	T	T	0.116	0.430	0.468	0.243	T	T	T	T	D	D	3.739	25.600	0.999	D	D	0.488	4.944	0.506	5.217	0.990	0.707	0.725	0.725	0.714	.	5.810	4.880	4.887	1.176	0.676	1.000	1.000	0.998	870	Anticodon-binding	.	.	.	EPRS1	103	0	158	22	0.122222222222222	TRUE	TRUE
ENSG00000158125.10	.	BCM	GRCh38.p13	chr2	31386524	31386524	+	C	C	T	Missense_Mutation	SNP	ENST00000379416.4	exon9	c.G683A	p.R228Q	exonic	ENSG00000158125.10	.	nonsynonymous SNV	ENSG00000158125.10:ENST00000379416.4:exon9:c.G683A:p.R228Q	2p23.1	C3N-00436	1.647e-05	0	0	0	0	1.498e-05	0	6.056e-05	rs745346331	2.20	T	T	B	B	N	N	M	T	N	0.434	T	T	T	0.059	0.342	0.321	0.041	T	T	T	T	T	D	1.418	15.210	0.916	N	N	-0.679	0.848	-0.670	0.944	0.999	0.554	0.547	0.602	0.564	.	5.700	2.900	3.604	1.026	0.589	0.921	0.188	0.234	928	Xanthine_dehydrogenase,_small_subunit	.	.	ID=COSV65148108;OCCURENCE=1(breast),3(large_intestine),1(skin)	XDH	517	0	970	80	0.0761904761904762	TRUE	TRUE
ENSG00000205221.12	.	BCM	GRCh38.p13	chr2	36808650	36808650	+	C	C	T	Missense_Mutation	SNP	ENST00000389975.7	exon14	c.C1523T	p.T508M	exonic	ENSG00000205221.12	.	nonsynonymous SNV	ENSG00000205221.12:ENST00000389975.7:exon14:c.C1523T:p.T508M	2p22.2	C3N-00436	1.649e-05	0	0	0.0001	0	1.501e-05	0	0	rs182729056	16.20	D	D	D	D	D	D	M	D	D	0.655	D	D	D	0.570	0.445	0.928	0.091	T	T	T	D	D	D	3.815	25.900	0.998	D	N	0.557	5.513	0.471	4.905	1.000	0.487	0.547	0.574	0.542	.	5.270	5.270	2.968	1.026	0.599	0.985	0.857	0.687	720	von_Willebrand_factor,_type_A	.	.	ID=COSV101007796;OCCURENCE=1(stomach)	VIT	240	0	395	46	0.104308390022676	TRUE	NA
ENSG00000183091.19	.	BCM	GRCh38.p13	chr2	151643979	151643979	+	T	T	A	Nonsense_Mutation	SNP	ENST00000172853.14	exon57	c.A7795T	p.K2599X	exonic	ENSG00000183091.19	.	stopgain	ENSG00000183091.19:ENST00000172853.14:exon57:c.A7795T:p.K2599X	2q23.3	C3N-00436	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.883	.	.	.	.	.	.	.	.	.	D	D	.	.	8.556	43	0.996	D	N	0.817	9.122	0.713	8.010	1.000	0.554	0.547	0.602	0.564	.	5.920	5.920	2.353	1.138	0.665	1.000	0.998	0.998	886	.	.	.	.	NEB	425	0	852	77	0.0828848223896663	NA	TRUE
ENSG00000144290.17	.	BCM	GRCh38.p13	chr2	161804521	161804521	+	G	G	A	Missense_Mutation	SNP	ENST00000446997.6	exon3	c.G203A	p.R68H	exonic	ENSG00000144290.17	.	nonsynonymous SNV	ENSG00000144290.17:ENST00000446997.6:exon3:c.G203A:p.R68H	2q24.2	C3N-00436	4.289e-05	0	0	0	0	7.742e-05	0	0	rs759420527	7.20	T	T	B	B	D	D	N	T	N	0.402	T	T	D	0.332	.	0.773	0.504	D	T	T	T	T	D	2.334	21.800	0.812	D	D	-0.191	1.903	0.058	2.570	0.882	0.554	0.574	0.602	0.542	.	5.360	5.360	6.706	1.176	0.676	1.000	1.000	0.995	680	.	.	.	ID=COSV55768636;OCCURENCE=1(central_nervous_system),1(haematopoietic_and_lymphoid_tissue),1(stomach),1(upper_aerodigestive_tract),1(endometrium)	SLC4A10	201	0	361	28	0.0719794344473008	TRUE	TRUE
ENSG00000178568.15	.	BCM	GRCh38.p13	chr2	211431076	211431076	+	G	G	A	Nonsense_Mutation	SNP	ENST00000342788.9	exon21	c.C2512T	p.R838X	exonic	ENSG00000178568.15	.	stopgain	ENSG00000178568.15:ENST00000342788.9:exon21:c.C2512T:p.R838X	2q34	C3N-00436	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.904	.	.	.	.	.	.	.	.	.	D	D	.	.	8.086	41	0.998	D	N	0.822	9.236	0.694	7.649	0.024	0.487	0.574	0.574	0.632	.	5.170	5.170	3.273	-0.133	0.676	1.000	0.962	0.980	515	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	ID=COSV61472598;OCCURENCE=1(oesophagus),2(large_intestine),1(kidney),1(pancreas),2(prostate),1(lung),1(upper_aerodigestive_tract),1(endometrium)	ERBB4	266	0	365	40	0.0987654320987654	TRUE	TRUE
ENSG00000163359.16	.	BCM	GRCh38.p13	chr2	237344602	237344602	+	C	C	G	Missense_Mutation	SNP	ENST00000295550.9	exon36	c.G7416C	p.K2472N	exonic	ENSG00000163359.16	.	nonsynonymous SNV	ENSG00000163359.16:ENST00000295550.9:exon36:c.G7416C:p.K2472N	2q37.3	C3N-00436	.	.	.	.	.	.	.	.	.	4.20	T	D	D	P	N	N	L	D	N	0.210	T	T	D	0.220	0.538	0.700	0.174	T	T	T	T	T	T	2.888	23.200	0.872	N	N	-0.871	0.558	-0.902	0.618	0.996	0.615	0.590	0.659	0.530	.	5.070	-3.010	0.622	-0.940	-0.218	0.546	0.261	0.890	955	von_Willebrand_factor,_type_A	.	.	.	COL6A3	225	0	353	27	0.0710526315789474	TRUE	TRUE
ENSG00000173040.13	.	BCM	GRCh38.p13	chr4	5628625	5628625	+	G	G	A	Missense_Mutation	SNP	ENST00000344408.10	exon12	c.C1820T	p.T607I	exonic	ENSG00000173040.13	.	nonsynonymous SNV	ENSG00000173040.13:ENST00000344408.10:exon12:c.C1820T:p.T607I	4p16.2	C3N-00436	.	.	.	.	.	.	.	.	rs1044253878	3.20	T	T	B	B	N	N	L	T	D	0.247	T	T	D	0.139	0.199	0.798	0.032	T	T	T	T	T	T	1.843	18.050	0.996	D	N	-0.270	1.690	-0.140	1.937	0.912	0.651	0.588	0.651	0.636	.	4.890	2.960	2.124	-0.564	0.618	1.000	0.058	0.982	929	.	.	.	.	EVC2	298	0	500	44	0.0808823529411765	TRUE	NA
ENSG00000197410.14	.	BCM	GRCh38.p13	chr4	154320987	154320987	+	G	G	A	Missense_Mutation	SNP	ENST00000357232.10	exon9	c.C4412T	p.T1471M	exonic	ENSG00000197410.14	.	nonsynonymous SNV	ENSG00000197410.14:ENST00000357232.10:exon9:c.C4412T:p.T1471M	4q31.3	C3N-00436	1.649e-05	9.614e-05	0	0.0001	0	0	0	0	rs774677154	0.11	.	.	.	.	N	N	.	.	.	.	T	T	T	0.070	.	.	0.105	T	.	T	T	T	.	0.834	9.734	0.750	N	N	-0.823	0.622	-0.780	0.785	0.004	0.487	0.574	0.574	0.564	.	5.690	-1.650	1.509	-1.535	-1.478	0.901	0.119	0.648	737	Cadherin-like	.	.	ID=COSV59717808;OCCURENCE=1(large_intestine),1(central_nervous_system),2(stomach)	DCHS2	138	0	256	29	0.101754385964912	TRUE	TRUE
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	169840803	169840803	+	G	G	A	Missense_Mutation	SNP	ENST00000520908.7	exon27	c.G2750A	p.R917Q	exonic	ENSG00000134516.18	.	nonsynonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon27:c.G2750A:p.R917Q	5q35.1	C3N-00436	8.318e-06	9.718e-05	0	0	0	0	0	0	rs765098414	10.20	D	D	B	B	D	D	M	T	D	0.544	T	T	T	0.215	0.487	0.677	1.344	T	T	T	T	D	D	3.573	24.900	0.999	D	D	-0.037	2.383	0.116	2.803	1.000	0.719	0.723	0.659	0.621	.	5.280	5.280	6.749	1.176	0.618	1.000	0.875	0.798	975	.	.	.	ID=COSV56969381;OCCURENCE=1(large_intestine),1(prostate)	DOCK2	234	0	508	40	0.072992700729927	TRUE	TRUE
ENSG00000113758.13	.	BCM	GRCh38.p13	chr5	177459220	177459220	+	G	G	A	Missense_Mutation	SNP	ENST00000309007.9	exon11	c.C1004T	p.T335M	exonic	ENSG00000113758.13	.	nonsynonymous SNV	ENSG00000113758.13:ENST00000309007.9:exon11:c.C1004T:p.T335M	5q35.3	C3N-00436	8.312e-06	0	0	0	0	1.514e-05	0	0	rs748335051	6.20	D	T	D	P	N	D	N	T	N	0.256	T	T	D	0.051	0.283	0.325	0.346	T	T	T	T	T	D	2.068	19.770	0.993	D	N	0.099	2.883	0.145	2.929	1.000	0.672	0.644	0.698	0.711	.	4.580	4.580	0.747	1.176	0.676	0.020	0.994	0.922	917	.	.	.	.	DBN1	191	1	426	41	0.0877944325481799	TRUE	NA
ENSG00000096093.16	.	BCM	GRCh38.p13	chr6	52438493	52438493	+	C	C	T	Missense_Mutation	SNP	ENST00000371068.11	exon3	c.C475T	p.R159W	exonic	ENSG00000096093.16	.	nonsynonymous SNV	ENSG00000096093.16:ENST00000371068.11:exon3:c.C475T:p.R159W	6p12.2	C3N-00436	0.1004	0.0520	0.0721	0.0352	0.1038	0.1254	0.1311	0.0807	rs3804506	3.19	T	T	D	B	N	N	M	T	N	0.176	T	T	.	0.179	.	.	0.187	T	T	T	T	T	D	1.913	18.590	0.998	N	N	-0.036	2.386	-0.139	1.940	0.004	0.638	0.670	0.653	0.668	.	5.560	2.710	1.033	0.062	0.599	0.000	0.978	0.998	841	Domain_of_unknown_function_DUF1126;Uncharacterised_domain_DM10	PAQR8	Cells_Cultured_fibroblasts;Brain_Cortex;Artery_Tibial;Thyroid;Whole_Blood	ID=COSV64137993;OCCURENCE=1(large_intestine)	EFHC1	261	0	418	38	0.0833333333333333	TRUE	TRUE
ENSG00000165171.11	.	BCM	GRCh38.p13	chr7	73840461	73840461	+	C	C	T	Missense_Mutation	SNP	ENST00000297873.9	exon4	c.G341A	p.R114H	exonic	ENSG00000165171.11	.	nonsynonymous SNV	ENSG00000165171.11:ENST00000297873.9:exon4:c.G341A:p.R114H	7q11.23	C3N-00436	1.959e-05	0	0	0	0	3.73e-05	0	0	rs782150735	0.19	T	T	B	B	N	N	.	T	N	0.042	T	T	T	0.019	0.425	0.102	0.150	T	T	T	T	T	T	-1.447	0.001	0.862	N	N	-1.656	0.044	-1.665	0.059	0.998	0.534	0.611	0.585	0.639	.	4.690	-3.760	-2.755	-2.101	-3.369	0.000	0.191	0.048	934	.	.	.	.	METTL27	216	0	394	36	0.0837209302325581	TRUE	NA
ENSG00000178462.12	.	BCM	GRCh38.p13	chr10	5394049	5394049	+	G	G	A	Missense_Mutation	SNP	ENST00000380419.8	exon4	c.C809T	p.P270L	exonic	ENSG00000178462.12	.	nonsynonymous SNV	ENSG00000178462.12:ENST00000380419.8:exon4:c.C809T:p.P270L	10p15.1	C3N-00436	8.237e-06	0	0	0	0	1.498e-05	0	0	rs140777769	17.20	D	D	D	D	N	D	H	D	D	0.632	D	D	T	0.739	.	0.966	0.408	T	D	D	D	D	D	2.395	22.100	0.997	D	D	0.516	5.159	0.273	3.561	0.418	0.516	0.574	0.574	0.586	.	4.200	3.290	6.725	1.176	0.676	1.000	0.008	0.003	964	Tubulin/FtsZ,_2-layer_sandwich_domain	.	.	ID=COSV66813873;OCCURENCE=1(large_intestine),1(kidney)	TUBAL3	214	1	278	34	0.108974358974359	TRUE	TRUE
ENSG00000181958.4	.	BCM	GRCh38.p13	chr11	55368080	55368080	+	C	C	T	Missense_Mutation	SNP	ENST00000314706.3	exon1	c.C197T	p.T66M	exonic	ENSG00000181958.4	.	nonsynonymous SNV	ENSG00000181958.4:ENST00000314706.3:exon1:c.C197T:p.T66M	11q11	C3N-00436	2.482e-05	0.0002	0	0	0	1.502e-05	0	0	rs199660751	7.20	D	D	D	P	D	N	M	T	D	0.342	T	T	T	0.060	.	0.319	.	T	T	T	T	D	T	1.953	18.900	0.997	N	N	-0.026	2.421	-0.343	1.478	0.000	0.487	0.574	0.574	0.564	.	3.480	2.530	0.948	-0.125	0.480	0.004	0.025	0.008	144	.	.	.	ID=COSV59033672;OCCURENCE=1(breast),6(large_intestine),1(central_nervous_system),1(prostate),2(lung),1(small_intestine)	OR4A15	186	0	312	26	0.0769230769230769	TRUE	TRUE
ENSG00000151067.22	.	BCM	GRCh38.p13	chr12	2457667	2457667	+	C	C	T	Missense_Mutation	SNP	ENST00000399655.6	exon5	c.C718T	p.R240C	exonic	ENSG00000151067.22	.	nonsynonymous SNV	ENSG00000151067.22:ENST00000399655.6:exon5:c.C718T:p.R240C	12p13.33	C3N-00436	.	.	.	.	.	.	.	.	.	19.19	D	D	D	D	D	D	H	D	D	0.957	D	D	D	0.924	0.774	0.997	2.568	D	D	D	D	D	.	3.993	26.900	0.999	D	D	0.889	10.765	0.706	7.872	0.517	0.534	0.590	0.686	0.564	.	4.150	4.150	2.060	1.026	0.599	1.000	0.994	0.994	968	Ion_transport_domain	.	.	ID=COSV59761814;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	CACNA1C	65	0	108	7	0.0608695652173913	TRUE	TRUE
ENSG00000111404.6	.	BCM	GRCh38.p13	chr12	18088929	18088929	+	C	C	T	Missense_Mutation	SNP	ENST00000229002.6	exon3	c.G83A	p.R28Q	exonic	ENSG00000111404.6	.	nonsynonymous SNV	ENSG00000111404.6:ENST00000229002.6:exon3:c.G83A:p.R28Q	12p12.3	C3N-00436	0.0006	0.0061	0.0003	0	0	4.503e-05	0	0	rs138852095	12.20	D	D	D	D	N	D	M	T	D	0.684	T	T	D	0.472	.	0.450	0.122	T	T	T	D	T	D	3.950	26.600	0.999	D	D	0.292	3.737	0.212	3.243	0.001	0.487	0.574	0.574	0.564	.	4.210	3.320	5.717	0.071	-0.276	0.996	0.939	0.834	946	.	.	.	ID=COSV57461417;OCCURENCE=1(large_intestine),1(NS)	RERGL	230	0	334	29	0.0798898071625344	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-00436	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	352	1	540	51	0.0862944162436548	TRUE	TRUE
ENSG00000185610.6	.	BCM	GRCh38.p13	chr12	45050660	45050660	+	C	C	G	Missense_Mutation	SNP	ENST00000332700.6	exon1	c.G268C	p.E90Q	exonic	ENSG00000185610.6	.	nonsynonymous SNV	ENSG00000185610.6:ENST00000332700.6:exon1:c.G268C:p.E90Q	12q12	C3N-00436	.	.	.	.	.	.	.	.	.	4.19	T	T	P	P	.	N	L	D	N	0.166	T	D	D	0.194	0.255	0.479	0.150	D	T	T	T	T	T	1.755	17.410	0.965	N	N	-0.417	1.347	-0.535	1.146	0.999	0.598	0.563	0.504	0.639	.	2.960	2.960	2.198	0.046	0.593	0.286	0.006	0.045	757	.	.	.	.	DBX2	193	0	394	23	0.0551558752997602	TRUE	TRUE
ENSG00000174373.16	.	BCM	GRCh38.p13	chr14	35549218	35549218	+	G	G	A	Nonsense_Mutation	SNP	ENST00000389698.7	exon39	c.C5995T	p.R1999X	exonic	ENSG00000174373.16	.	stopgain	ENSG00000174373.16:ENST00000389698.7:exon39:c.C5995T:p.R1999X	14q13.2	C3N-00436	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.464	.	.	.	.	.	.	.	.	.	D	D	.	.	8.835	45	0.995	D	N	0.819	9.164	0.670	7.220	0.965	0.554	0.588	0.602	0.568	.	5.200	5.200	7.128	1.176	0.618	1.000	0.999	0.995	444	Rap_GTPase_activating_protein_domain	.	.	ID=COSV51878805;OCCURENCE=3(large_intestine),1(central_nervous_system)	RALGAPA1	197	0	298	26	0.0802469135802469	TRUE	TRUE
ENSG00000100678.19	.	BCM	GRCh38.p13	chr14	70167626	70167626	+	C	C	T	Missense_Mutation	SNP	ENST00000381269.6	exon2	c.G797A	p.R266H	exonic	ENSG00000100678.19	.	nonsynonymous SNV	ENSG00000100678.19:ENST00000381269.6:exon2:c.G797A:p.R266H	14q24.2	C3N-00436	1.648e-05	9.612e-05	0	0	0	1.499e-05	0	0	rs375603290	15.20	D	D	D	D	D	D	M	T	D	0.810	T	T	D	0.505	.	0.520	0.746	T	D	T	D	D	D	4.009	27.000	0.999	D	D	0.955	12.561	0.910	14.171	1.000	0.554	0.610	0.618	0.564	.	5.710	5.710	7.899	1.026	0.599	1.000	1.000	0.999	665	Sodium/calcium_exchanger_domain,_C-terminal_extension	.	.	ID=COSV63519686;OCCURENCE=1(large_intestine),1(pancreas),1(endometrium)	SLC8A3	453	0	755	52	0.0644361833952912	TRUE	TRUE
ENSG00000172349.17	.	BCM	GRCh38.p13	chr15	81225671	81225671	+	A	A	T	Missense_Mutation	SNP	ENST00000302987.8	exon1	c.A272T	p.N91I	exonic	ENSG00000172349.17	.	nonsynonymous SNV	ENSG00000172349.17:ENST00000302987.8:exon1:c.A272T:p.N91I	15q25.1	C3N-00436	.	.	.	.	.	.	.	.	.	2.20	D	D	B	B	N	N	N	T	N	0.459	T	T	T	0.017	0.276	0.067	0.175	T	T	T	T	T	T	1.035	12.060	0.961	N	N	-0.921	0.494	-0.970	0.528	0.999	0.554	0.588	0.574	0.564	.	4.180	0.824	0.308	-0.195	-0.793	0.016	0.605	0.006	814	.	.	.	.	IL16	94	0	167	12	0.0670391061452514	TRUE	TRUE
ENSG00000140553.18	.	BCM	GRCh38.p13	chr15	90950524	90950524	+	G	G	A	Missense_Mutation	SNP	ENST00000418476.2	exon17	c.G2212A	p.V738I	exonic	ENSG00000140553.18	.	nonsynonymous SNV	ENSG00000140553.18:ENST00000418476.2:exon17:c.G2212A:p.V738I	15q26.1	C3N-00436	.	.	.	.	.	.	.	.	.	6.20	T	T	D	D	D	D	L	T	N	0.387	T	T	T	0.195	0.359	0.542	0.118	T	T	T	T	T	T	3.376	24.300	0.997	D	D	0.507	5.094	0.548	5.632	1.000	0.707	0.725	0.725	0.711	.	5.410	5.410	6.582	1.176	0.676	1.000	0.993	0.953	538	.	.	.	.	UNC45A	205	0	378	31	0.0757946210268949	TRUE	NA
ENSG00000185864.16	.	BCM	GRCh38.p13	chr16	21837124	21837124	+	G	G	-	Frame_Shift_Del	NA	ENST00000415645.6	exon7	c.1263delC	p.S422Qfs*207	exonic	ENSG00000185864.16	.	frameshift deletion	ENSG00000185864.16:ENST00000415645.6:exon7:c.1263delC:p.S422Qfs*207	16p12.2	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NPIPB4	21	0	18	7	0.28	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674894	7674894	+	G	G	A	Nonsense_Mutation	SNP	ENST00000269305.8	exon6	c.C637T	p.R213X	exonic	ENSG00000141510.17	.	stopgain	ENSG00000141510.17:ENST00000269305.8:exon6:c.C637T:p.R213X	17p13.1	C3N-00436	8.255e-06	0	0	0	0	1.5e-05	0	0	rs397516436	5.6	.	.	.	.	D	A	.	.	.	0.994	.	.	.	.	.	.	.	.	.	D	D	.	.	7.994	40	0.998	D	N	0.425	4.504	0.212	3.241	0.134	0.722	0.698	0.702	0.735	.	5.280	3.250	0.754	1.176	0.676	0.602	0.994	0.998	433	p53,_DNA-binding_domain	.	.	ID=COSV52665560;OCCURENCE=4(salivary_gland),95(breast),2(penis),1(peritoneum),9(liver),59(oesophagus),1(adrenal_gland),1(cervix),148(large_intestine),20(central_nervous_system),10(biliary_tract),1(pleura),15(ovary),2(bone),9(NS),21(haematopoietic_and_lymphoid_tissue),38(stomach),12(urinary_tract),9(soft_tissue),6(kidney),28(pancreas),52(skin),12(prostate),30(lung),8(thyroid),42(upper_aerodigestive_tract),2(small_intestine),28(endometrium)	TP53	510	0	689	72	0.0946123521681997	TRUE	TRUE
ENSG00000007171.18	.	BCM	GRCh38.p13	chr17	27774420	27774420	+	G	G	A	Missense_Mutation	SNP	ENST00000313735.11	exon12	c.C1313T	p.S438L	exonic	ENSG00000007171.18	.	nonsynonymous SNV	ENSG00000007171.18:ENST00000313735.11:exon12:c.C1313T:p.S438L	17q11.2	C3N-00436	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.688	T	T	D	0.450	0.631	0.653	0.432	T	T	D	T	D	D	4.206	28.700	0.999	D	D	0.886	10.700	0.872	12.621	1.000	0.615	0.590	0.659	0.613	.	5.670	5.670	9.932	1.176	0.676	1.000	0.618	0.918	185	Nitric_oxide_synthase,_N-terminal	.	.	.	NOS2	41	0	68	7	0.0933333333333333	TRUE	NA
ENSG00000108256.9	.	BCM	GRCh38.p13	chr17	29286841	29286841	+	A	A	C	Missense_Mutation	SNP	ENST00000225388.9	exon2	c.T1153G	p.S385A	exonic	ENSG00000108256.9	.	nonsynonymous SNV	ENSG00000108256.9:ENST00000225388.9:exon2:c.T1153G:p.S385A	17q11.2	C3N-00436	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	D	L	.	N	0.345	T	T	T	0.112	0.194	0.282	0.104	T	T	T	T	T	T	1.520	15.870	0.372	D	N	-0.339	1.521	-0.125	1.978	1.000	0.672	0.698	0.702	0.711	.	5.630	4.350	2.512	1.312	0.756	0.979	0.988	0.890	387	.	.	.	.	NUFIP2	269	0	397	37	0.0852534562211982	TRUE	TRUE
ENSG00000171401.15	.	BCM	GRCh38.p13	chr17	41502402	41502402	+	G	G	A	Missense_Mutation	SNP	ENST00000246635.8	exon6	c.C1216T	p.R406C	exonic	ENSG00000171401.15	.	nonsynonymous SNV	ENSG00000171401.15:ENST00000246635.8:exon6:c.C1216T:p.R406C	17q21.2	C3N-00436	5.766e-05	0.0005	0	0	0	1.498e-05	0	6.056e-05	rs138885186	16.20	D	T	P	P	D	D	M	D	D	0.955	D	D	D	0.777	.	0.952	0.565	T	D	D	D	D	D	4.275	29.400	0.999	D	D	0.371	4.169	0.389	4.279	0.656	0.554	0.563	0.616	0.568	.	4.450	4.450	3.674	1.176	0.606	1.000	1.000	0.997	440	Intermediate_filament,_rod_domain;Intermediate_filament_protein,_conserved_site	.	.	.	KRT13	403	0	775	72	0.0850059031877214	TRUE	NA
ENSG00000198862.14	.	BCM	GRCh38.p13	chr21	28966407	28966407	+	T	T	A	Missense_Mutation	SNP	ENST00000361371.10	exon10	c.A2084T	p.D695V	exonic	ENSG00000198862.14	.	nonsynonymous SNV	ENSG00000198862.14:ENST00000361371.10:exon10:c.A2084T:p.D695V	21q21.3	C3N-00436	.	.	.	.	.	.	.	.	.	2.20	D	T	B	B	N	N	L	T	D	0.298	T	T	T	0.031	0.290	0.257	0.397	T	T	T	T	T	T	2.476	22.400	0.959	N	N	-0.667	0.869	-0.635	0.994	0.108	0.672	0.546	0.609	0.711	.	5.130	2.690	0.979	0.200	0.665	0.001	0.926	0.983	964	.	.	.	.	LTN1	169	0	227	14	0.0580912863070539	TRUE	TRUE
ENSG00000146938.16	.	BCM	GRCh38.p13	chrX	5893158	5893158	+	G	G	A	Missense_Mutation	SNP	ENST00000381095.8	exon6	c.C2110T	p.R704C	exonic	ENSG00000146938.16	.	nonsynonymous SNV	ENSG00000146938.16:ENST00000381095.8:exon6:c.C2110T:p.R704C	Xp22.32	C3N-00436	1.14e-05	0	0	0	0	2.084e-05	0	0	rs751945904	13.19	D	D	D	D	N	D	L	T	D	0.568	D	T	D	0.437	.	0.723	2.465	D	D	T	T	D	D	3.787	25.800	0.999	D	.	.	.	.	.	0.979	.	.	.	.	.	3.810	3.810	6.579	1.006	0.676	1.000	0.944	0.873	1000	.	.	.	ID=COSV52015100;OCCURENCE=1(breast),3(large_intestine),1(endometrium)	NLGN4X	437	0	729	85	0.104422604422604	NA	TRUE
ENSG00000130032.17	.	BCM	GRCh38.p13	chrX	151700044	151700044	+	G	G	A	Missense_Mutation	SNP	ENST00000674457.1	exon3	c.G56A	p.R19H	exonic	ENSG00000130032.17	.	nonsynonymous SNV	ENSG00000130032.17:ENST00000674457.1:exon3:c.G56A:p.R19H	Xq28	C3N-00436	.	.	.	.	.	.	.	.	.	15.19	D	D	B	B	D	D	M	D	D	0.506	D	D	D	0.768	0.854	0.425	0.026	T	T	D	D	D	D	2.911	23.200	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.020	4.130	6.651	1.083	0.676	0.995	0.999	0.998	810	Gamma-carboxyglutamic_acid-rich_(GLA)_domain	.	.	.	PRRG3	110	0	198	16	0.0747663551401869	TRUE	NA
ENSG00000072518.20	.	BCM	GRCh38.p13	chr11	63895578	63895578	+	A	A	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000072518.20	ENST00000402010.6:exon3:c.235-2A>T	.	.	11q13.1	C3N-00436	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.438	34	0.993	D	.	1.101	17.528	0.957	16.425	1.000	0.295	0.304	0.121	0.090	0.976	5.930	5.930	5.929	1.312	0.756	1.000	0.871	0.656	402	.	.	.	.	MARK2	316	0	479	41	0.0788461538461538	TRUE	TRUE
ENSG00000118200.14	.	BCM	GRCh38.p13	chr1	200847285	200847285	+	A	A	C	Silent	SNP	ENST00000236925.8	exon10	c.A1218C	p.S406S	exonic	ENSG00000118200.14	.	synonymous SNV	ENSG00000118200.14:ENST00000236925.8:exon10:c.A1218C:p.S406S	1q32.1	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CAMSAP2	210	0	422	35	0.0765864332603939	TRUE	TRUE
ENSG00000172554.12	.	BCM	GRCh38.p13	chr2	1209111	1209111	+	G	G	A	Silent	SNP	ENST00000308624.10	exon9	c.G600A	p.S200S	exonic	ENSG00000172554.12	.	synonymous SNV	ENSG00000172554.12:ENST00000308624.10:exon9:c.G600A:p.S200S	2p25.3	C3N-00436	0.0002	0	0	0.0021	0	5.999e-05	0	0	rs141600263	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57967650;OCCURENCE=2(oesophagus),1(biliary_tract)	SNTG2	205	0	311	32	0.0932944606413994	TRUE	TRUE
ENSG00000172752.14	.	BCM	GRCh38.p13	chr3	130391459	130391459	+	C	C	T	Silent	SNP	ENST00000265379.10	exon7	c.C2697T	p.H899H	exonic	ENSG00000172752.14	.	synonymous SNV	ENSG00000172752.14:ENST00000265379.10:exon7:c.C2697T:p.H899H	3q22.1	C3N-00436	0.0155	0.0208	0.0049	0	0.0588	0.0228	0.0266	0.0076	rs148235459	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55217935;OCCURENCE=1(large_intestine)	COL6A5	319	0	568	51	0.0823909531502423	TRUE	TRUE
ENSG00000204392.11	.	BCM	GRCh38.p13	chr6	31797862	31797862	+	G	G	A	Silent	SNP	ENST00000375661.6	exon5	c.C183T	p.F61F	exonic	ENSG00000204392.11	.	synonymous SNV	ENSG00000204392.11:ENST00000375661.6:exon5:c.C183T:p.F61F	6p21.33	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LSM2	344	0	542	57	0.0951585976627713	TRUE	TRUE
ENSG00000079841.18	.	BCM	GRCh38.p13	chr6	72290838	72290838	+	G	G	A	Silent	SNP	ENST00000521978.5	exon25	c.G3714A	p.A1238A	exonic	ENSG00000079841.18	.	synonymous SNV	ENSG00000079841.18:ENST00000521978.5:exon25:c.G3714A:p.A1238A	6q13	C3N-00436	2.508e-05	0.0002	0	0	0	1.51e-05	0	0	rs373917034	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53487652;OCCURENCE=1(large_intestine),1(stomach),1(lung)	RIMS1	121	0	236	35	0.129151291512915	TRUE	TRUE
ENSG00000106443.16	.	BCM	GRCh38.p13	chr7	11042726	11042726	+	T	T	C	Silent	SNP	ENST00000403050.7	exon13	c.T2224C	p.L742L	exonic	ENSG00000106443.16	.	synonymous SNV	ENSG00000106443.16:ENST00000403050.7:exon13:c.T2224C:p.L742L	7p21.3	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PHF14	211	0	318	29	0.0835734870317003	TRUE	TRUE
ENSG00000147687.19	.	BCM	GRCh38.p13	chr8	124493916	124493916	+	T	T	C	Silent	SNP	ENST00000276692.11	exon11	c.A708G	p.K236K	exonic	ENSG00000147687.19	.	synonymous SNV	ENSG00000147687.19:ENST00000276692.11:exon11:c.A708G:p.K236K	8q24.13	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TATDN1	178	0	270	28	0.0939597315436242	TRUE	TRUE
ENSG00000150347.16	.	BCM	GRCh38.p13	chr10	62092166	62092166	+	G	G	A	Silent	SNP	ENST00000279873.12	exon10	c.G2703A	p.T901T	exonic	ENSG00000150347.16	.	synonymous SNV	ENSG00000150347.16:ENST00000279873.12:exon10:c.G2703A:p.T901T	10q21.2	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARID5B	65	0	102	11	0.0973451327433628	TRUE	NA
ENSG00000198682.13	.	BCM	GRCh38.p13	chr10	87727408	87727408	+	C	C	T	Silent	SNP	ENST00000361175.8	exon8	c.C990T	p.D330D	exonic	ENSG00000198682.13	.	synonymous SNV	ENSG00000198682.13:ENST00000361175.8:exon8:c.C990T:p.D330D	10q23.31	C3N-00436	1.655e-05	0	0	0	0	0	0.0022	0	rs183111777	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63262646;OCCURENCE=1(breast)	PAPSS2	599	0	960	92	0.0874524714828897	TRUE	TRUE
ENSG00000170953.3	.	BCM	GRCh38.p13	chr11	124543301	124543301	+	C	C	T	Silent	SNP	ENST00000306842.2	exon1	c.G354A	p.A118A	exonic	ENSG00000170953.3	.	synonymous SNV	ENSG00000170953.3:ENST00000306842.2:exon1:c.G354A:p.A118A	11q24.2	C3N-00436	1.65e-05	9.615e-05	0	0	0	1.499e-05	0	0	rs764768343	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60911867;OCCURENCE=1(large_intestine),2(prostate)	OR8B12	200	0	344	34	0.0899470899470899	TRUE	TRUE
ENSG00000129219.14	.	BCM	GRCh38.p13	chr17	4816986	4816986	+	G	G	A	Silent	SNP	ENST00000263088.11	exon16	c.G1632A	p.G544G	exonic	ENSG00000129219.14	.	synonymous SNV	ENSG00000129219.14:ENST00000263088.11:exon16:c.G1632A:p.G544G	17p13.2	C3N-00436	1.655e-05	9.632e-05	0	0	0	1.504e-05	0	0	rs774811005	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLD2	139	0	243	19	0.0725190839694656	TRUE	NA
ENSG00000141458.13	.	BCM	GRCh38.p13	chr18	23551661	23551661	+	T	T	C	Silent	SNP	ENST00000269228.10	exon10	c.A1620G	p.P540P	exonic	ENSG00000141458.13	.	synonymous SNV	ENSG00000141458.13:ENST00000269228.10:exon10:c.A1620G:p.P540P	18q11.2	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NPC1	526	0	866	112	0.114519427402863	TRUE	TRUE
ENSG00000090889.12	.	BCM	GRCh38.p13	chrX	70405875	70405875	+	G	G	A	Silent	SNP	ENST00000374403.4	exon26	c.G2946A	p.Q982Q	exonic	ENSG00000090889.12	.	synonymous SNV	ENSG00000090889.12:ENST00000374403.4:exon26:c.G2946A:p.Q982Q	Xq13.1	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIF4A	282	0	436	38	0.080168776371308	TRUE	TRUE
ENSG00000196440.11	.	BCM	GRCh38.p13	chrX	101490041	101490041	+	C	C	G	Silent	SNP	ENST00000423738.4	exon2	c.C1452G	p.T484T	exonic	ENSG00000196440.11	.	synonymous SNV	ENSG00000196440.11:ENST00000423738.4:exon2:c.C1452G:p.T484T	Xq22.1	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARMCX4	305	0	470	39	0.0766208251473477	TRUE	TRUE
ENSG00000198354.7	.	BCM	GRCh38.p13	chrX	126164901	126164901	+	G	G	T	Silent	SNP	ENST00000360028.4	exon1	c.C1024A	p.R342R	exonic	ENSG00000198354.7	.	synonymous SNV	ENSG00000198354.7:ENST00000360028.4:exon1:c.C1024A:p.R342R	Xq25	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DCAF12L2	224	0	409	34	0.0767494356659142	TRUE	TRUE
ENSG00000198910.14	.	BCM	GRCh38.p13	chrX	153870399	153870399	+	G	G	A	Silent	SNP	ENST00000370060.7	exon8	c.C795T	p.I265I	exonic	ENSG00000198910.14	.	synonymous SNV	ENSG00000198910.14:ENST00000370060.7:exon8:c.C795T:p.I265I	Xq28	C3N-00436	3.466e-05	0	0	0	0	4.225e-05	0	9.923e-05	rs141383999	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	L1CAM	505	1	828	76	0.084070796460177	TRUE	NA
ENSG00000158473.8	.	BCM	GRCh38.p13	chr1	158182402	158182402	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000158473.8	.	.	.	1q23.1	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CD1D	107	0	190	12	0.0594059405940594	TRUE	NA
ENSG00000131508.16	.	BCM	GRCh38.p13	chr5	139562279	139562279	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000131508.16	.	.	.	5q31.2	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBE2D2	225	0	392	37	0.0862470862470862	TRUE	NA
ENSG00000188385.12	.	BCM	GRCh38.p13	chr10	132168218	132168218	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000188385.12	ENST00000664697.1:c.*288G>A	.	.	10q26.3	C3N-00436	8.357e-05	0	0	0.0051	0	0	0	0	rs779013303	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	JAKMIP3	191	0	309	44	0.124645892351275	TRUE	NA
ENSG00000279770.1	.	BCM	GRCh38.p13	chr13	113750681	113750681	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000279770.1	.	.	.	13q34	C3N-00436	.	.	.	.	.	.	.	.	rs933438975	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC00552	270	0	595	47	0.073208722741433	TRUE	NA
ENSG00000187483.9	.	BCM	GRCh38.p13	chr14	94644994	94644994	+	A	A	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000187483.9	.	.	.	14q32.13	C3N-00436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SERPINA13P	196	0	272	35	0.11400651465798	TRUE	NA
ENSG00000173838.12	.	BCM	GRCh38.p13	chr17	62746904	62746904	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000173838.12	.	.	.	17q23.2	C3N-00436	.	.	.	.	.	.	.	.	.	0.9	.	T	.	.	.	N	.	T	.	0.107	.	.	T	.	.	0.424	.	.	.	T	T	.	T	1.305	14.430	0.346	N	N	.	.	.	.	0.978	0.487	0.574	0.547	0.542	.	3.450	-2.110	0.410	0.579	-0.279	0.000	0.001	0.000	607	.	.	.	.	MARCHF10	236	1	374	46	0.10952380952381	TRUE	TRUE
ENSG00000184611.12	.	BCM	GRCh38.p13	chr2	162517798	162517798	+	G	G	A	Missense_Mutation	SNP	ENST00000332142.10	exon4	c.C824T	p.S275L	exonic	ENSG00000184611.12	.	nonsynonymous SNV	ENSG00000184611.12:ENST00000332142.10:exon4:c.C824T:p.S275L	2q24.2	C3L-00928	8.267e-06	0	0	0	0	1.504e-05	0	0	rs139430414	18.20	D	D	D	D	D	D	M	D	D	0.767	D	D	D	0.766	.	0.928	1.129	T	T	D	D	D	D	4.095	27.700	0.999	D	D	0.860	10.068	0.879	12.867	1.000	0.554	0.574	0.618	0.564	.	5.900	5.900	9.280	1.176	0.676	1.000	1.000	0.996	509	.	.	.	ID=COSV59792617;OCCURENCE=2(skin),1(endometrium)	KCNH7	123	0	198	25	0.112107623318386	TRUE	TRUE
ENSG00000153827.13	.	BCM	GRCh38.p13	chr2	229859381	229859381	+	T	T	G	Missense_Mutation	SNP	ENST00000283943.9	exon3	c.A292C	p.T98P	exonic	ENSG00000153827.13	.	nonsynonymous SNV	ENSG00000153827.13:ENST00000283943.9:exon3:c.A292C:p.T98P	2q36.3	C3L-00928	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	N	T	D	0.122	T	T	T	0.204	0.082	0.314	0.658	T	T	T	T	T	D	2.116	20.200	0.983	D	N	-0.395	1.394	-0.156	1.895	0.983	0.706	0.725	0.710	0.714	.	5.850	4.680	1.143	1.135	0.665	1.000	1.000	0.997	876	.	.	.	.	TRIP12	390	0	669	49	0.0682451253481894	TRUE	TRUE
ENSG00000134121.10	.	BCM	GRCh38.p13	chr3	361705	361705	+	G	G	A	Missense_Mutation	SNP	ENST00000397491.6	exon12	c.G1265A	p.R422H	exonic	ENSG00000134121.10	.	nonsynonymous SNV	ENSG00000134121.10:ENST00000397491.6:exon12:c.G1265A:p.R422H	3p26.3	C3L-00928	7.419e-05	0.0002	0	0.0001	0	8.995e-05	0	0	rs759628440	2.19	D	D	B	B	N	N	.	T	N	0.186	T	T	T	0.085	.	0.208	0.012	T	T	T	T	T	T	1.294	14.350	0.993	N	N	-0.861	0.571	-0.840	0.703	0.000	0.487	0.547	0.574	0.564	.	5.240	-1.030	0.357	-0.192	0.676	0.003	0.208	0.912	963	.	.	.	ID=COSV56592328;OCCURENCE=3(large_intestine)	CHL1	127	0	153	17	0.1	TRUE	TRUE
ENSG00000144771.8	.	BCM	GRCh38.p13	chr3	54918709	54918709	+	G	G	A	Missense_Mutation	SNP	ENST00000273286.6	exon3	c.C788T	p.A263V	exonic	ENSG00000144771.8	.	nonsynonymous SNV	ENSG00000144771.8:ENST00000273286.6:exon3:c.C788T:p.A263V	3p14.3	C3L-00928	8.259e-06	0	8.673e-05	0	0	0	0	0	rs779554165	0.20	T	T	B	B	N	N	N	T	N	0.122	T	T	T	0.009	0.175	0.154	0.016	T	T	T	T	T	T	-1.315	0.001	0.796	N	N	-1.710	0.035	-1.719	0.047	1.000	0.487	0.574	0.547	0.564	.	4.790	-1.270	-1.983	-1.076	-2.424	0.000	0.000	0.000	754	.	.	.	ID=COSV55513807;OCCURENCE=1(oesophagus),2(stomach)	LRTM1	230	0	453	52	0.102970297029703	TRUE	TRUE
ENSG00000174963.17	.	BCM	GRCh38.p13	chr3	147391003	147391003	+	G	G	A	Missense_Mutation	SNP	ENST00000383075.7	exon4	c.C932T	p.S311L	exonic	ENSG00000174963.17	.	nonsynonymous SNV	ENSG00000174963.17:ENST00000383075.7:exon4:c.C932T:p.S311L	3q24	C3L-00928	.	.	.	.	.	.	.	.	rs998956801	6.19	T	T	B	B	N	.	L	T	D	0.214	T	T	D	0.034	0.236	0.357	1.262	T	T	T	T	D	D	3.015	23.400	0.997	D	D	-0.209	1.852	-0.066	2.147	1.000	0.437	0.590	0.607	0.530	.	5.180	4.290	5.274	0.245	0.676	1.000	0.796	0.994	899	.	.	.	ID=COSV67172689;OCCURENCE=1(breast),1(pancreas)	ZIC4	240	0	632	60	0.0867052023121387	TRUE	TRUE
ENSG00000214944.9	.	BCM	GRCh38.p13	chr5	73873056	73873056	+	T	T	C	Missense_Mutation	SNP	ENST00000513042.6	exon22	c.T2624C	p.F875S	exonic	ENSG00000214944.9	.	nonsynonymous SNV	ENSG00000214944.9:ENST00000513042.6:exon22:c.T2624C:p.F875S	5q13.2	C3L-00928	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	.	D	M	T	D	0.957	D	D	D	0.878	0.851	0.883	0.549	T	T	D	D	D	D	4.299	29.600	0.999	D	D	0.833	9.455	0.784	9.664	1.000	0.707	0.588	0.618	0.714	.	5.540	5.540	4.936	1.138	0.665	1.000	1.000	1.000	888	Dbl_homology_(DH)_domain	.	.	.	ARHGEF28	303	0	548	33	0.0567986230636833	TRUE	TRUE
ENSG00000112852.7	.	BCM	GRCh38.p13	chr5	141097024	141097024	+	G	G	A	Missense_Mutation	SNP	ENST00000194155.7	exon1	c.G2234A	p.G745E	exonic	ENSG00000112852.7	.	nonsynonymous SNV	ENSG00000112852.7:ENST00000194155.7:exon1:c.G2234A:p.G745E	5q31.3	C3L-00928	.	.	.	.	.	.	.	.	.	7.19	D	D	P	B	.	D	M	T	D	0.098	T	T	D	0.169	0.493	0.424	.	T	T	T	T	T	T	2.132	20.300	0.960	D	N	-0.252	1.736	-0.333	1.497	0.000	0.660	0.574	0.663	0.586	.	4.580	2.790	2.943	-0.548	-0.768	0.999	0.065	0.001	466	Cadherin,_cytoplasmic_C-terminal_domain	.	.	.	PCDHB2	216	0	507	44	0.0798548094373866	NA	TRUE
ENSG00000113263.13	.	BCM	GRCh38.p13	chr5	157244432	157244432	+	A	A	G	Missense_Mutation	SNP	ENST00000422843.8	exon13	c.A1403G	p.E468G	exonic	ENSG00000113263.13	.	nonsynonymous SNV	ENSG00000113263.13:ENST00000422843.8:exon13:c.A1403G:p.E468G	5q33.3	C3L-00928	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.763	D	D	D	0.840	0.565	0.963	1.322	T	D	D	D	D	D	4.288	29.500	0.999	D	D	0.855	9.950	0.861	12.190	1.000	0.554	0.588	0.547	0.564	.	6.080	6.080	9.146	1.312	0.691	1.000	1.000	0.999	437	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	ITK	380	0	762	88	0.103529411764706	TRUE	TRUE
ENSG00000072803.17	.	BCM	GRCh38.p13	chr5	171876326	171876326	+	C	C	T	Missense_Mutation	SNP	ENST00000265094.9	exon8	c.G1117A	p.D373N	exonic	ENSG00000072803.17	.	nonsynonymous SNV	ENSG00000072803.17:ENST00000265094.9:exon8:c.G1117A:p.D373N	5q35.1	C3L-00928	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	D	D	L	T	N	0.656	T	T	T	0.117	0.517	0.382	1.344	D	T	T	T	D	D	2.808	23.000	0.998	D	D	-0.026	2.421	0.224	3.302	1.000	0.707	0.702	0.698	0.714	.	5.590	5.590	7.858	1.026	0.599	1.000	0.965	0.962	934	WD40-repeat-containing_domain	.	.	ID=COSV51611631;OCCURENCE=1(large_intestine)	FBXW11	249	0	707	48	0.0635761589403974	TRUE	TRUE
ENSG00000008083.14	.	BCM	GRCh38.p13	chr6	15513352	15513352	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000341776.7	exon16	c.3381dupA	p.W1129Vfs*58	exonic	ENSG00000008083.14	.	frameshift insertion	ENSG00000008083.14:ENST00000341776.7:exon16:c.3381dupA:p.W1129Vfs*58	6p22.3	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	JARID2	NA	NA	NA	NA	NA	NA	NA
ENSG00000119508.18	.	BCM	GRCh38.p13	chr9	99833411	99833411	+	G	G	A	Missense_Mutation	SNP	ENST00000395097.7	exon5	c.G1211A	p.R404Q	exonic	ENSG00000119508.18	.	nonsynonymous SNV	ENSG00000119508.18:ENST00000395097.7:exon5:c.G1211A:p.R404Q	9q31.1	C3L-00928	1.651e-05	0	0	0	0	3.004e-05	0	0	rs778148069	19.20	D	D	D	D	D	D	M	D	D	0.469	D	D	D	0.462	0.334	0.937	.	T	D	D	D	D	D	4.135	28.100	1.000	D	D	0.845	9.729	0.848	11.702	1.000	0.516	0.588	0.577	0.530	.	5.710	5.710	7.808	1.176	0.676	1.000	1.000	0.991	809	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	ID=COSV58243692;OCCURENCE=1(large_intestine)	NR4A3	228	0	321	23	0.0668604651162791	TRUE	TRUE
ENSG00000186881.3	.	BCM	GRCh38.p13	chr9	104504554	104504554	+	G	G	A	Missense_Mutation	SNP	ENST00000334726.3	exon1	c.G292A	p.A98T	exonic	ENSG00000186881.3	.	nonsynonymous SNV	ENSG00000186881.3:ENST00000334726.3:exon1:c.G292A:p.A98T	9q31.1	C3L-00928	0.0001	0	8.637e-05	0	0	0.0002	0	0	rs143065377	3.20	D	T	P	B	N	N	M	T	D	0.093	T	T	T	0.074	.	0.366	0.033	T	T	T	T	T	T	1.340	14.670	0.992	N	N	-0.034	2.391	-0.105	2.034	0.000	0.487	0.574	0.547	0.564	.	4.260	3.360	-0.286	1.175	0.676	0.000	0.969	0.966	595	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58251213;OCCURENCE=2(stomach),1(thyroid),1(upper_aerodigestive_tract)	OR13F1	249	1	507	37	0.0680147058823529	TRUE	TRUE
ENSG00000165124.18	.	BCM	GRCh38.p13	chr9	110406765	110406765	+	T	T	G	Missense_Mutation	SNP	ENST00000374469.6	exon38	c.A8835C	p.K2945N	exonic	ENSG00000165124.18	.	nonsynonymous SNV	ENSG00000165124.18:ENST00000374469.6:exon38:c.A8835C:p.K2945N	9q31.3	C3L-00928	.	.	.	.	.	.	.	.	.	4.17	.	D	P	B	D	N	L	.	.	0.205	T	T	T	0.094	0.491	0.043	0.424	T	T	T	T	D	T	2.002	19.270	0.976	D	N	-0.240	1.767	-0.175	1.847	0.000	0.554	0.563	0.618	0.564	.	5.450	3.110	0.380	0.202	-0.188	0.998	1.000	0.992	969	Sushi/SCR/CCP_domain	.	.	.	SVEP1	174	0	314	37	0.105413105413105	TRUE	TRUE
ENSG00000107290.14	.	BCM	GRCh38.p13	chr9	132311818	132311818	+	A	A	C	Missense_Mutation	SNP	ENST00000224140.6	exon11	c.T5313G	p.N1771K	exonic	ENSG00000107290.14	.	nonsynonymous SNV	ENSG00000107290.14:ENST00000224140.6:exon11:c.T5313G:p.N1771K	9q34.13	C3L-00928	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	D	N	0.093	T	T	D	0.252	0.487	0.407	0.085	T	T	T	T	T	T	1.082	12.590	0.425	N	N	-0.873	0.554	-0.706	0.892	0.981	0.732	0.744	0.651	0.714	.	5.070	0.157	0.171	0.271	0.756	0.925	0.943	0.983	958	.	.	.	.	SETX	332	1	279	25	0.0822368421052632	TRUE	TRUE
ENSG00000149452.16	.	BCM	GRCh38.p13	chr11	62993328	62993328	+	C	C	T	Missense_Mutation	SNP	ENST00000336232.7	exon11	c.G1538A	p.R513Q	exonic	ENSG00000149452.16	.	nonsynonymous SNV	ENSG00000149452.16:ENST00000336232.7:exon11:c.G1538A:p.R513Q	11q12.3	C3L-00928	0.0029	0.0002	8.856e-05	0	0.0120	0.0038	0.0068	6.217e-05	rs145474422	0.19	T	T	B	B	N	N	N	T	N	0.069	T	T	.	0.043	.	0.217	0.395	T	T	T	T	T	T	-0.452	0.149	0.587	N	N	-1.970	0.010	-2.077	0.009	1.000	0.487	0.563	0.574	0.542	.	5.250	-10.500	-5.000	-1.677	-0.924	0.000	0.000	0.008	804	.	.	.	ID=COSV60327069;OCCURENCE=1(NS),1(haematopoietic_and_lymphoid_tissue)	SLC22A8	146	0	447	37	0.0764462809917355	TRUE	TRUE
ENSG00000137672.13	.	BCM	GRCh38.p13	chr11	101491653	101491653	+	G	G	A	Missense_Mutation	SNP	ENST00000344327.8	exon3	c.C1031T	p.A344V	exonic	ENSG00000137672.13	.	nonsynonymous SNV	ENSG00000137672.13:ENST00000344327.8:exon3:c.C1031T:p.A344V	11q22.1	C3L-00928	.	.	.	.	.	.	.	.	.	11.20	T	T	D	D	D	D	L	T	N	0.908	T	T	D	0.360	0.506	0.882	1.007	T	T	D	D	D	D	4.096	27.700	0.998	D	D	0.609	6.016	0.624	6.531	1.000	0.554	0.574	0.618	0.564	.	6.140	6.140	9.889	1.176	0.676	1.000	0.971	0.414	830	.	.	.	.	TRPC6	240	0	393	34	0.0796252927400468	TRUE	TRUE
ENSG00000184232.9	.	BCM	GRCh38.p13	chr11	120226939	120226939	+	G	G	A	Missense_Mutation	SNP	ENST00000328965.9	exon3	c.G490A	p.E164K	exonic	ENSG00000184232.9	.	nonsynonymous SNV	ENSG00000184232.9:ENST00000328965.9:exon3:c.G490A:p.E164K	11q23.3	C3L-00928	8.309e-06	0	0	0.0001	0	0	0	0	rs748586285	14.20	D	D	D	P	D	D	M	T	D	0.834	T	T	D	0.392	.	0.608	1.496	T	T	D	D	D	D	4.006	27.000	0.999	D	D	0.719	7.399	0.656	6.999	1.000	0.635	0.634	0.686	0.646	.	5.430	5.430	9.602	1.176	0.676	1.000	0.328	0.461	389	.	.	.	.	OAF	118	0	192	16	0.0769230769230769	TRUE	NA
ENSG00000284680.1	.	BCM	GRCh38.p13	chr11	124382937	124382937	+	A	A	G	Missense_Mutation	SNP	ENST00000641451.1	exon2	c.T407C	p.M136T	exonic	ENSG00000284680.1	.	nonsynonymous SNV	ENSG00000284680.1:ENST00000641451.1:exon2:c.T407C:p.M136T	11q24.2	C3L-00928	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	D	D	H	T	D	0.435	T	T	T	0.287	0.480	0.496	0.636	T	T	T	T	D	T	2.944	23.300	0.983	D	D	0.400	4.346	0.404	4.385	0.933	0.487	0.574	0.547	0.564	.	4.200	4.200	7.075	1.190	0.615	1.000	0.998	0.972	853	GPCR,_rhodopsin-like,_7TM	.	.	.	OR8B2	153	0	240	26	0.0977443609022556	NA	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-00928	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	293	0	361	35	0.0883838383838384	TRUE	TRUE
ENSG00000123104.12	.	BCM	GRCh38.p13	chr12	26398935	26398935	+	T	T	A	Missense_Mutation	SNP	ENST00000381340.8	exon54	c.A7637T	p.D2546V	exonic	ENSG00000123104.12	.	nonsynonymous SNV	ENSG00000123104.12:ENST00000381340.8:exon54:c.A7637T:p.D2546V	12p11.23	C3L-00928	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.837	D	D	D	0.894	0.446	0.957	2.098	D	D	D	D	D	D	4.514	32	0.993	D	D	0.778	8.362	0.731	8.375	1.000	0.732	0.744	0.659	0.728	.	4.960	4.960	7.956	1.120	0.644	1.000	1.000	0.995	915	Ion_transport_domain	.	.	.	ITPR2	152	0	202	19	0.085972850678733	TRUE	TRUE
ENSG00000154237.13	.	BCM	GRCh38.p13	chr15	101066063	101066063	+	G	G	A	Missense_Mutation	SNP	ENST00000388948.8	exon32	c.G5626A	p.E1876K	exonic	ENSG00000154237.13	.	nonsynonymous SNV	ENSG00000154237.13:ENST00000388948.8:exon32:c.G5626A:p.E1876K	15q26.3	C3L-00928	0.0001	0	0	0	0	0.0002	0	6.058e-05	rs369774424	7.19	D	T	D	B	N	D	M	T	N	0.613	T	T	D	0.282	.	0.886	0.680	T	T	T	T	T	D	2.809	23.000	0.999	D	.	0.433	4.552	0.430	4.576	1.000	0.707	0.702	0.659	0.714	.	5.610	5.610	5.729	1.176	0.676	1.000	0.166	0.096	870	.	.	.	ID=COSV52601368;OCCURENCE=1(large_intestine),1(skin)	LRRK1	291	0	767	72	0.0858164481525626	TRUE	TRUE
ENSG00000140691.17	.	BCM	GRCh38.p13	chr16	31459902	31459902	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000268314.9	exon1	c.379dupA	p.T128Dfs*59	exonic	ENSG00000140691.17	.	frameshift insertion	ENSG00000140691.17:ENST00000268314.9:exon1:c.379dupA:p.T128Dfs*59	16p11.2	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARMC5	NA	NA	NA	NA	NA	NA	NA
ENSG00000277363.5	.	BCM	GRCh38.p13	chr17	38561611	38561611	+	C	C	T	Missense_Mutation	SNP	ENST00000617146.5	exon7	c.G1552A	p.V518I	exonic	ENSG00000277363.5	.	nonsynonymous SNV	ENSG00000277363.5:ENST00000617146.5:exon7:c.G1552A:p.V518I	17q12	C3L-00928	.	.	.	.	.	.	.	.	.	6.12	.	T	.	.	D	D	.	.	.	0.277	T	T	T	0.125	.	0.546	.	D	.	T	T	D	.	3.081	23.600	0.998	D	D	0.476	4.854	0.377	4.200	1.000	0.598	0.627	0.504	0.639	.	4.740	3.760	4.793	0.962	0.524	0.996	0.906	0.352	193	.	.	.	.	SRCIN1	76	1	284	27	0.0868167202572347	TRUE	TRUE
ENSG00000129932.10	.	BCM	GRCh38.p13	chr19	3496726	3496726	+	G	G	A	Missense_Mutation	SNP	ENST00000427575.6	exon2	c.C89T	p.T30M	exonic	ENSG00000129932.10	.	nonsynonymous SNV	ENSG00000129932.10:ENST00000427575.6:exon2:c.C89T:p.T30M	19p13.3	C3L-00928	2.53e-05	0.0001	0	0	0	1.54e-05	0	6.083e-05	rs368504297	11.19	T	D	D	D	D	D	M	.	D	0.770	T	T	D	0.394	.	0.457	0.617	T	T	T	T	T	D	3.246	24.000	0.998	D	D	0.451	4.677	0.304	3.742	1.000	0.707	0.702	0.725	0.714	.	4.280	3.190	7.280	1.164	0.662	1.000	0.667	0.558	952	.	.	.	.	DOHH	237	0	699	68	0.0886571056062582	TRUE	NA
ENSG00000198028.4	.	BCM	GRCh38.p13	chr19	9466585	9466585	+	T	T	C	Missense_Mutation	SNP	ENST00000301480.5	exon10	c.A2362G	p.K788E	exonic	ENSG00000198028.4	.	nonsynonymous SNV	ENSG00000198028.4:ENST00000301480.5:exon10:c.A2362G:p.K788E	19p13.2	C3L-00928	.	.	.	.	.	.	.	.	.	2.19	D	D	P	P	.	N	L	T	N	0.087	T	T	T	0.038	0.515	0.211	0.064	T	T	T	T	T	T	1.965	18.990	0.905	N	N	-0.614	0.962	-0.875	0.654	0.000	0.487	0.574	0.574	0.564	.	2.020	-0.443	-0.443	0.788	0.566	0.000	0.163	0.375	952	Zinc_finger_C2H2-type	.	.	.	ZNF560	62	0	60	7	0.104477611940299	TRUE	TRUE
ENSG00000179954.16	.	BCM	GRCh38.p13	chr19	55518829	55518829	+	G	G	A	Missense_Mutation	SNP	ENST00000389623.11	exon14	c.G4553A	p.R1518H	exonic	ENSG00000179954.16	.	nonsynonymous SNV	ENSG00000179954.16:ENST00000389623.11:exon14:c.G4553A:p.R1518H	19q13.42	C3L-00928	.	.	.	.	.	.	.	.	rs748017648	1.19	D	T	B	B	.	N	N	T	N	0.159	T	T	T	0.043	.	0.120	0.015	T	T	T	T	T	T	2.052	19.650	0.608	N	N	-0.734	0.756	-0.628	1.004	0.999	0.554	0.588	0.604	0.568	.	3.410	0.905	0.937	0.224	-0.211	0.438	0.982	0.744	958	.	.	.	ID=COSV67476898;OCCURENCE=1(large_intestine)	SSC5D	357	0	845	93	0.0991471215351812	TRUE	TRUE
ENSG00000087460.25	.	BCM	GRCh38.p13	chr20	58895657	58895657	+	T	T	G	Missense_Mutation	SNP	ENST00000371100.8	exon2	c.T2114G	p.I705S	exonic	ENSG00000087460.25	.	nonsynonymous SNV	ENSG00000087460.25:ENST00000371100.8:exon2:c.T2114G:p.I705S	20q13.32	C3L-00928	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.946	D	D	D	0.944	0.806	0.998	1.519	D	D	D	D	D	D	4.611	32	0.995	D	D	0.648	6.453	0.656	6.996	1.000	0.646	0.672	0.672	0.723	.	5.630	5.630	7.674	1.138	0.609	1.000	1.000	0.999	986	.	.	.	.	GNAS	297	2	393	35	0.0817757009345794	TRUE	TRUE
ENSG00000170214.5	.	BCM	GRCh38.p13	chr5	159971877	159971877	+	A	A	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000170214.5	ENST00000306675.5:exon2:c.950-2A>C	.	.	5q33.3	C3L-00928	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.070	35	0.993	D	.	1.049	15.527	0.872	12.617	1.000	0.167	0.110	0.182	0.109	0.809	4.560	4.560	8.646	1.187	0.733	1.000	0.994	0.961	923	.	.	.	.	ADRA1B	18	1	41	7	0.145833333333333	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673534	7673534	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon9:c.993+1G>A	.	.	17p13.1	C3L-00928	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.717	32	0.992	D	.	0.909	11.283	0.710	7.951	1.000	0.284	0.279	0.217	0.082	0.971	4.410	4.410	2.328	1.012	0.596	1.000	0.988	0.907	435	.	.	.	ID=COSV52699909;OCCURENCE=1(salivary_gland),13(breast),5(oesophagus),8(large_intestine),6(ovary),5(haematopoietic_and_lymphoid_tissue),3(stomach),1(urinary_tract),1(kidney),1(soft_tissue),4(pancreas),1(skin),3(lung),3(upper_aerodigestive_tract)	TP53	361	0	491	41	0.0770676691729323	TRUE	TRUE
ENSG00000184144.12	.	BCM	GRCh38.p13	chr1	205069850	205069850	+	C	C	T	Silent	SNP	ENST00000331830.7	exon18	c.C2220T	p.N740N	exonic	ENSG00000184144.12	.	synonymous SNV	ENSG00000184144.12:ENST00000331830.7:exon18:c.C2220T:p.N740N	1q32.1	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNTN2	147	0	375	37	0.0898058252427184	TRUE	TRUE
ENSG00000168542.16	.	BCM	GRCh38.p13	chr2	189009052	189009052	+	G	G	A	Silent	SNP	ENST00000304636.9	exon48	c.G3654A	p.P1218P	exonic	ENSG00000168542.16	.	synonymous SNV	ENSG00000168542.16:ENST00000304636.9:exon48:c.G3654A:p.P1218P	2q32.2	C3L-00928	3.295e-05	0	0	0.0002	0	2.997e-05	0	0	rs35759441	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58591332;OCCURENCE=1(central_nervous_system),1(stomach)	COL3A1	236	0	447	32	0.0668058455114822	TRUE	TRUE
ENSG00000144460.12	.	BCM	GRCh38.p13	chr2	225513647	225513647	+	C	C	T	Silent	SNP	ENST00000636099.1	exon4	c.C498T	p.S166S	exonic	ENSG00000144460.12	.	synonymous SNV	ENSG00000144460.12:ENST00000636099.1:exon4:c.C498T:p.S166S	2q36.3	C3L-00928	0.0022	0.0221	0.0007	0.0005	0	0.0001	0.0026	0.0008	rs61738635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55997451;OCCURENCE=1(breast)	NYAP2	24	0	79	5	0.0595238095238095	TRUE	TRUE
ENSG00000158683.8	.	BCM	GRCh38.p13	chr7	47829494	47829494	+	T	T	C	Silent	SNP	ENST00000289672.6	exon44	c.A6666G	p.E2222E	exonic	ENSG00000158683.8	.	synonymous SNV	ENSG00000158683.8:ENST00000289672.6:exon44:c.A6666G:p.E2222E	7p12.3	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PKD1L1	155	0	313	28	0.0821114369501466	TRUE	TRUE
ENSG00000169398.19	.	BCM	GRCh38.p13	chr8	140818322	140818322	+	G	G	T	Silent	SNP	ENST00000522684.5	exon10	c.C822A	p.I274I	exonic	ENSG00000169398.19	.	synonymous SNV	ENSG00000169398.19:ENST00000522684.5:exon10:c.C822A:p.I274I	8q24.3	C3L-00928	1.648e-05	9.614e-05	0	0	0	1.499e-05	0	0	rs758593102	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTK2	244	0	436	32	0.0683760683760684	TRUE	NA
ENSG00000130635.16	.	BCM	GRCh38.p13	chr9	134728723	134728723	+	C	C	T	Silent	SNP	ENST00000371817.8	exon6	c.C840T	p.Y280Y	exonic	ENSG00000130635.16	.	synonymous SNV	ENSG00000130635.16:ENST00000371817.8:exon6:c.C840T:p.Y280Y	9q34.3	C3L-00928	8.245e-06	0	0	0	0	0	0	6.056e-05	rs765347784	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65669270;OCCURENCE=2(large_intestine),1(prostate)	COL5A1	342	0	728	59	0.0749682337992376	TRUE	TRUE
ENSG00000187609.16	.	BCM	GRCh38.p13	chr9	137351110	137351110	+	C	C	T	Silent	SNP	ENST00000340951.9	exon14	c.G1422A	p.T474T	exonic	ENSG00000187609.16	.	synonymous SNV	ENSG00000187609.16:ENST00000340951.9:exon14:c.G1422A:p.T474T	9q34.3	C3L-00928	0.0009	0.0003	0.0027	0	0	0.0010	0.004	0.0006	rs370478324	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EXD3	171	0	465	36	0.0718562874251497	TRUE	NA
ENSG00000183049.12	.	BCM	GRCh38.p13	chr10	12814201	12814201	+	C	C	T	Silent	SNP	ENST00000619168.4	exon7	c.C648T	p.C216C	exonic	ENSG00000183049.12	.	synonymous SNV	ENSG00000183049.12:ENST00000619168.4:exon7:c.C648T:p.C216C	10p13	C3L-00928	0.0002	0.0010	0.0002	0	0	0.0002	0	0.0002	rs137946643	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CAMK1D	66	0	161	13	0.0747126436781609	TRUE	NA
ENSG00000148600.15	.	BCM	GRCh38.p13	chr10	84211033	84211033	+	G	G	A	Silent	SNP	ENST00000623527.4	exon13	c.G1353A	p.K451K	exonic	ENSG00000148600.15	.	synonymous SNV	ENSG00000148600.15:ENST00000623527.4:exon13:c.G1353A:p.K451K	10q23.1	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDHR1	318	0	685	74	0.0974967061923584	TRUE	TRUE
ENSG00000197674.7	.	BCM	GRCh38.p13	chr11	4691529	4691529	+	G	G	A	Silent	SNP	ENST00000641159.1	exon2	c.C168T	p.H56H	exonic	ENSG00000197674.7	.	synonymous SNV	ENSG00000197674.7:ENST00000641159.1:exon2:c.C168T:p.H56H	11p15.4	C3L-00928	.	.	.	.	.	.	.	.	rs193262556	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR51C1P	86	0	167	14	0.0773480662983425	TRUE	NA
ENSG00000149972.11	.	BCM	GRCh38.p13	chr11	99844955	99844955	+	C	C	A	Silent	SNP	ENST00000524871.6	exon5	c.C381A	p.G127G	exonic	ENSG00000149972.11	.	synonymous SNV	ENSG00000149972.11:ENST00000524871.6:exon5:c.C381A:p.G127G	11q22.1	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNTN5	80	0	85	9	0.0957446808510638	TRUE	NA
ENSG00000126561.16	.	BCM	GRCh38.p13	chr17	42289927	42289927	+	C	C	T	Silent	SNP	ENST00000345506.8	exon4	c.C190T	p.L64L	exonic	ENSG00000126561.16	.	synonymous SNV	ENSG00000126561.16:ENST00000345506.8:exon4:c.C190T:p.L64L	17q21.2	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STAT5A	84	0	189	15	0.0735294117647059	TRUE	NA
ENSG00000120094.9	.	BCM	GRCh38.p13	chr17	48530617	48530617	+	A	A	T	Silent	SNP	ENST00000239174.7	exon1	c.T288A	p.S96S	exonic	ENSG00000120094.9	.	synonymous SNV	ENSG00000120094.9:ENST00000239174.7:exon1:c.T288A:p.S96S	17q21.32	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HOXB1	217	0	622	50	0.0744047619047619	TRUE	TRUE
ENSG00000267680.5	.	BCM	GRCh38.p13	chr19	44107229	44107229	+	C	C	A	Silent	SNP	ENST00000336976.10	exon6	c.C1069A	p.R357R	exonic	ENSG00000267680.5	.	synonymous SNV	ENSG00000267680.5:ENST00000336976.10:exon6:c.C1069A:p.R357R	19q13.31	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF224	44	0	27	3	0.1	TRUE	NA
ENSG00000267680.5	.	BCM	GRCh38.p13	chr19	44108137	44108137	+	G	G	A	Silent	SNP	ENST00000336976.10	exon6	c.G1977A	p.K659K	exonic	ENSG00000267680.5	.	synonymous SNV	ENSG00000267680.5:ENST00000336976.10:exon6:c.G1977A:p.K659K	19q13.31	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF224	267	0	429	39	0.0833333333333333	NA	TRUE
ENSG00000220575.8	.	BCM	GRCh38.p13	chr7	155070325	155070325	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000220575.8	.	.	.	7q36.2	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HTR5A-AS1	68	1	213	16	0.0698689956331878	TRUE	NA
ENSG00000147457.14	.	BCM	GRCh38.p13	chr8	23248184	23248184	+	C	C	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000147457.14	.	.	.	8p21.3	C3L-00928	.	.	.	.	.	.	.	.	.	2.13	D	D	.	.	.	N	.	.	N	.	T	T	.	0.033	0.273	0.123	.	.	T	T	T	T	T	0.854	9.939	0.869	N	N	-0.561	1.059	-0.741	0.841	0.999	0.493	0.587	0.537	0.323	.	3.090	-1.080	-0.197	0.128	-0.182	0.003	0.172	0.112	760	.	.	.	.	CHMP7	174	0	401	30	0.0696055684454756	TRUE	TRUE
ENSG00000139636.15	.	BCM	GRCh38.p13	chr12	49109754	49109754	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000139636.15	.	.	.	12q13.12	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LMBR1L	142	0	257	25	0.0886524822695035	TRUE	NA
ENSG00000179242.16	.	BCM	GRCh38.p13	chr20	61499483	61499483	+	T	T	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000179242.16	.	.	.	20q13.33	C3L-00928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDH4	150	0	340	26	0.0710382513661202	TRUE	NA
ENSG00000162426.14	.	BCM	GRCh38.p13	chr1	8324438	8324438	+	C	C	T	Nonsense_Mutation	SNP	ENST00000471889.5	exon2	c.C211T	p.R71X	exonic	ENSG00000162426.14	.	stopgain	ENSG00000162426.14:ENST00000471889.5:exon2:c.C211T:p.R71X	1p36.23	C3L-01124	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.247	.	.	.	.	.	.	.	.	.	D	D	.	.	6.300	35	0.998	D	N	0.493	4.984	0.268	3.538	0.997	0.554	0.610	0.576	0.621	.	4.340	3.410	2.981	0.088	0.549	0.988	0.525	0.681	909	.	.	.	ID=COSV57096740;OCCURENCE=1(stomach),1(pancreas),1(skin)	SLC45A1	451	0	419	35	0.0770925110132159	TRUE	TRUE
ENSG00000163568.15	.	BCM	GRCh38.p13	chr1	159066271	159066271	+	C	C	T	Missense_Mutation	SNP	ENST00000368130.9	exon4	c.G455A	p.R152H	exonic	ENSG00000163568.15	.	nonsynonymous SNV	ENSG00000163568.15:ENST00000368130.9:exon4:c.G455A:p.R152H	1q23.1	C3L-01124	1.652e-05	0	0	0.0001	0	0	0	6.061e-05	rs144121944	1.19	D	T	B	B	.	N	N	T	N	0.102	T	T	T	0.019	.	0.371	0.293	T	T	T	T	T	T	-0.345	0.251	0.853	N	N	-1.665	0.042	-1.750	0.042	1.000	0.757	0.858	0.659	0.613	.	3.130	-5.410	-1.010	-1.442	-2.038	0.000	0.000	0.001	917	HIN-200/IF120x	.	.	.	AIM2	168	0	133	9	0.0633802816901408	TRUE	NA
ENSG00000120332.16	.	BCM	GRCh38.p13	chr1	175135857	175135857	+	C	C	T	Missense_Mutation	SNP	ENST00000239462.9	exon16	c.C3343T	p.R1115W	exonic	ENSG00000120332.16	.	nonsynonymous SNV	ENSG00000120332.16:ENST00000239462.9:exon16:c.C3343T:p.R1115W	1q25.1	C3L-01124	2.471e-05	9.61e-05	0	0	0	2.997e-05	0	0	rs546877646	18.20	D	D	D	D	D	D	H	D	D	0.914	D	D	D	0.855	0.925	0.983	0.502	T	T	D	D	D	D	3.925	26.500	0.999	D	D	0.711	7.270	0.543	5.580	0.033	0.497	0.590	0.547	0.542	.	5.650	2.540	0.633	1.026	0.599	0.994	1.000	0.996	684	Fibrinogen,_alpha/beta/gamma_chain,_C-terminal_globular_domain	.	.	ID=COSV53435922;OCCURENCE=2(large_intestine)	TNN	298	0	221	31	0.123015873015873	TRUE	TRUE
ENSG00000123612.16	.	BCM	GRCh38.p13	chr2	157556209	157556209	+	T	T	C	Missense_Mutation	SNP	ENST00000243349.13	exon3	c.A428G	p.Y143C	exonic	ENSG00000123612.16	.	nonsynonymous SNV	ENSG00000123612.16:ENST00000243349.13:exon3:c.A428G:p.Y143C	2q24.1	C3L-01124	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	N	L	D	D	0.365	T	D	D	0.166	0.344	0.909	0.798	T	T	T	T	T	T	1.788	17.650	0.943	N	N	-0.638	0.920	-0.604	1.040	0.000	0.554	0.574	0.602	0.564	.	5.640	4.480	0.610	-0.153	0.605	0.001	0.000	0.949	694	.	.	.	.	ACVR1C	325	0	310	26	0.0773809523809524	TRUE	TRUE
ENSG00000128683.14	.	BCM	GRCh38.p13	chr2	170858873	170858873	+	C	C	T	Nonsense_Mutation	SNP	ENST00000358196.8	exon16	c.C1591T	p.R531X	exonic	ENSG00000128683.14	.	stopgain	ENSG00000128683.14:ENST00000358196.8:exon16:c.C1591T:p.R531X	2q31.1	C3L-01124	8.266e-06	9.628e-05	0	0	0	0	0	0	rs745595462	5.6	.	.	.	.	D	D	.	.	.	0.939	.	.	.	.	.	.	.	.	.	D	D	.	.	7.924	40	0.998	D	N	0.916	11.484	0.795	9.963	0.996	0.554	0.588	0.618	0.530	.	5.630	4.670	5.242	1.026	0.599	1.000	0.997	0.957	446	.	.	.	.	GAD1	524	0	444	41	0.0845360824742268	TRUE	NA
ENSG00000196950.14	.	BCM	GRCh38.p13	chr2	195680815	195680815	+	G	G	A	Missense_Mutation	SNP	ENST00000359634.10	exon2	c.G773A	p.G258D	exonic	ENSG00000196950.14	.	nonsynonymous SNV	ENSG00000196950.14:ENST00000359634.10:exon2:c.G773A:p.G258D	2q32.3	C3L-01124	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.237	T	T	T	0.146	0.156	0.231	0.287	T	T	T	T	T	T	2.052	19.650	0.990	D	N	-0.315	1.577	-0.135	1.950	0.100	0.707	0.654	0.702	0.714	.	4.820	3.920	1.583	1.089	0.618	1.000	0.999	0.998	910	.	.	.	.	SLC39A10	205	0	168	13	0.0718232044198895	TRUE	TRUE
ENSG00000115524.17	.	BCM	GRCh38.p13	chr2	197401887	197401887	+	C	C	T	Missense_Mutation	SNP	ENST00000335508.11	exon16	c.G2225A	p.G742D	exonic	ENSG00000115524.17	.	nonsynonymous SNV	ENSG00000115524.17:ENST00000335508.11:exon16:c.G2225A:p.G742D	2q33.1	C3L-01124	1.665e-05	0	0	0	0	3.02e-05	0	0	rs755415626	15.20	T	T	D	P	D	D	M	T	D	0.874	D	T	D	0.535	0.483	0.747	2.960	D	D	D	D	D	D	3.255	24.000	0.997	D	D	0.630	6.239	0.562	5.781	1.000	0.707	0.702	0.725	0.711	.	5.710	4.830	7.847	0.966	0.530	1.000	1.000	0.975	615	.	.	.	ID=COSV59205440;OCCURENCE=1(breast),2(cervix),61(haematopoietic_and_lymphoid_tissue),1(kidney),2(lung)	SF3B1	107	0	75	5	0.0625	NA	TRUE
ENSG00000113360.16	.	BCM	GRCh38.p13	chr5	31526173	31526173	+	G	G	A	Missense_Mutation	SNP	ENST00000511367.6	exon4	c.C760T	p.R254C	exonic	ENSG00000113360.16	.	nonsynonymous SNV	ENSG00000113360.16:ENST00000511367.6:exon4:c.C760T:p.R254C	5p13.3	C3L-01124	3.323e-05	0	0	0.0001	0	3.003e-05	0	6.128e-05	rs761643386	7.20	D	D	B	B	D	D	L	T	D	0.539	T	T	T	0.091	.	0.497	0.259	T	T	T	T	T	D	3.139	23.700	0.996	D	N	-0.154	2.010	0.018	2.422	1.000	0.707	0.725	0.725	0.714	.	4.450	4.450	1.405	1.083	0.676	1.000	0.988	0.987	728	.	.	.	.	DROSHA	188	0	145	11	0.0705128205128205	TRUE	NA
ENSG00000111817.19	.	BCM	GRCh38.p13	chr6	116437103	116437103	+	C	C	G	Missense_Mutation	SNP	ENST00000644252.3	exon6	c.C2635G	p.R879G	exonic	ENSG00000111817.19	.	nonsynonymous SNV	ENSG00000111817.19:ENST00000644252.3:exon6:c.C2635G:p.R879G	6q22.1	C3L-01124	.	.	.	.	.	.	.	.	.	1.20	T	D	B	B	N	N	L	T	N	0.077	T	T	T	0.050	.	0.331	0.329	T	T	T	T	T	T	1.777	17.560	0.954	N	N	-0.742	0.744	-0.684	0.923	0.963	0.732	0.702	0.644	0.728	.	5.940	4.100	2.393	0.088	0.599	0.049	0.139	0.167	471	.	.	.	.	DSE	197	0	140	9	0.0604026845637584	TRUE	NA
ENSG00000146350.14	.	BCM	GRCh38.p13	chr6	121292086	121292086	+	T	T	G	Missense_Mutation	SNP	ENST00000398212.7	exon12	c.A1339C	p.K447Q	exonic	ENSG00000146350.14	.	nonsynonymous SNV	ENSG00000146350.14:ENST00000398212.7:exon12:c.A1339C:p.K447Q	6q22.31	C3L-01124	.	.	.	.	.	.	.	.	.	8.19	T	D	B	B	D	D	M	T	N	0.271	T	T	T	0.052	0.326	0.230	0.134	.	T	T	T	D	D	2.433	22.200	0.982	D	D	-0.075	2.256	0.082	2.663	0.011	0.554	0.588	0.547	0.621	.	5.900	4.740	4.357	0.170	0.665	1.000	0.988	0.999	743	.	.	.	.	TBC1D32	87	0	45	4	0.0816326530612245	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01124	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	292	0	251	25	0.0905797101449275	TRUE	TRUE
ENSG00000139915.21	.	BCM	GRCh38.p13	chr14	47144182	47144182	+	C	C	A	Missense_Mutation	SNP	ENST00000399232.8	exon4	c.G688T	p.A230S	exonic	ENSG00000139915.21	.	nonsynonymous SNV	ENSG00000139915.21:ENST00000399232.8:exon4:c.G688T:p.A230S	14q21.3	C3L-01124	.	.	.	.	.	.	.	.	.	8.19	T	.	B	B	U	D	M	T	N	.	T	T	T	0.159	0.690	0.168	.	D	T	D	D	D	T	2.341	21.800	0.995	D	D	0.256	3.561	0.421	4.508	1.000	0.487	0.574	0.574	0.564	.	5.730	5.730	5.769	1.008	0.549	1.000	0.958	0.977	832	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV62077732;OCCURENCE=1(liver)	MDGA2	126	0	113	7	0.0583333333333333	TRUE	TRUE
ENSG00000039523.20	.	BCM	GRCh38.p13	chr16	67540120	67540120	+	G	G	A	Missense_Mutation	SNP	ENST00000379312.7	exon7	c.G494A	p.R165H	exonic	ENSG00000039523.20	.	nonsynonymous SNV	ENSG00000039523.20:ENST00000379312.7:exon7:c.G494A:p.R165H	16q22.1	C3L-01124	3.297e-05	0	0.0003	0	0	0	0	6.056e-05	rs369864235	8.19	T	D	D	P	D	D	.	T	D	0.511	T	T	D	0.093	.	0.177	1.639	T	T	T	T	T	D	4.048	27.300	0.999	D	N	0.412	4.416	0.442	4.667	1.000	0.722	0.698	0.494	0.735	.	5.140	4.170	3.847	1.176	0.618	1.000	1.000	0.991	28	FAM65,_N-terminal	.	.	.	RIPOR1	344	0	315	29	0.0843023255813953	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673764	7673764	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G856A	p.E286K	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G856A:p.E286K	17p13.1	C3L-01124	.	.	.	.	.	.	.	.	rs786201059	19.20	D	D	D	D	D	D	M	D	D	0.904	D	D	D	0.949	0.916	0.988	0.398	T	D	D	D	D	D	4.292	29.500	0.999	D	D	0.816	9.100	0.714	8.022	0.999	0.722	0.702	0.725	0.735	.	4.990	4.990	7.905	1.022	0.596	1.000	0.056	0.987	432	p53,_DNA-binding_domain	.	.	ID=COSV52664318;OCCURENCE=17(breast),4(liver),18(oesophagus),3(adrenal_gland),22(large_intestine),5(central_nervous_system),3(biliary_tract),5(ovary),3(vulva),1(NS),9(haematopoietic_and_lymphoid_tissue),7(stomach),9(urinary_tract),3(soft_tissue),2(pancreas),29(skin),1(prostate),11(lung),2(thyroid),20(upper_aerodigestive_tract),2(small_intestine)	TP53	693	0	582	51	0.0805687203791469	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51058136	51058137	+	AG	AG	-	Frame_Shift_Del	DEL	ENST00000342988.8	exon6	c.679_680del	p.S227Yfs*7	exonic	ENSG00000141646.14	.	frameshift deletion	ENSG00000141646.14:ENST00000342988.8:exon6:c.679_680del:p.S227Yfs*7	18q21.2	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMAD4	357	0	276	28	0.0921052631578947	TRUE	TRUE
ENSG00000072958.8	.	BCM	GRCh38.p13	chr19	16226520	16226520	+	G	G	A	Missense_Mutation	SNP	ENST00000291439.7	exon6	c.G646A	p.D216N	exonic	ENSG00000072958.8	.	nonsynonymous SNV	ENSG00000072958.8:ENST00000291439.7:exon6:c.G646A:p.D216N	19p13.11	C3L-01124	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.865	T	T	D	0.414	0.890	0.786	2.182	D	T	T	T	D	D	4.341	29.900	0.999	D	D	0.695	7.043	0.622	6.504	1.000	0.706	0.702	0.710	0.714	.	3.970	3.970	9.640	1.083	0.676	1.000	0.884	0.975	946	Mu_homology_domain	.	.	.	AP1M1	129	0	95	9	0.0865384615384615	TRUE	NA
ENSG00000131941.8	.	BCM	GRCh38.p13	chr19	33011712	33011712	+	G	G	A	Missense_Mutation	SNP	ENST00000254260.8	exon6	c.C560T	p.P187L	exonic	ENSG00000131941.8	.	nonsynonymous SNV	ENSG00000131941.8:ENST00000254260.8:exon6:c.C560T:p.P187L	19q13.11	C3L-01124	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	D	D	M	T	D	0.583	T	T	D	0.375	0.407	0.672	1.037	T	T	T	T	D	D	3.824	25.900	0.999	D	D	0.778	8.365	0.717	8.081	1.000	0.707	0.654	0.725	0.655	.	4.890	4.890	9.754	1.174	0.676	1.000	0.534	0.317	856	BRO1_domain	.	.	.	RHPN2	588	1	573	40	0.065252854812398	NA	TRUE
ENSG00000170638.9	.	BCM	GRCh38.p13	chr22	50194351	50194351	+	G	G	A	Missense_Mutation	SNP	ENST00000303434.8	exon4	c.G124A	p.A42T	exonic	ENSG00000170638.9	.	nonsynonymous SNV	ENSG00000170638.9:ENST00000303434.8:exon4:c.G124A:p.A42T	22q13.33	C3L-01124	6.037e-05	0	0	0	0	0.0001	0	0	rs747329304	3.19	T	T	B	B	D	D	L	.	N	0.296	T	T	T	0.052	0.188	0.110	0.330	T	T	T	T	T	T	3.394	24.400	0.998	D	N	-0.046	2.351	0.108	2.766	1.000	0.722	0.699	0.723	0.714	.	5.270	5.270	5.828	1.144	0.658	1.000	0.273	0.375	693	.	.	.	.	TRABD	159	1	146	13	0.0817610062893082	TRUE	NA
ENSG00000197915.7	.	BCM	GRCh38.p13	chr1	152220351	152220351	+	G	G	A	Silent	SNP	ENST00000368801.4	exon3	c.C1278T	p.H426H	exonic	ENSG00000197915.7	.	synonymous SNV	ENSG00000197915.7:ENST00000368801.4:exon3:c.C1278T:p.H426H	1q21.3	C3L-01124	0.0058	0.0629	0.0020	0	0	0.0002	0.0022	0.0004	rs11204936	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64261077;OCCURENCE=1(oesophagus),1(large_intestine)	HRNR	666	0	577	38	0.0617886178861789	TRUE	TRUE
ENSG00000163531.15	.	BCM	GRCh38.p13	chr1	205016380	205016380	+	C	C	T	Silent	SNP	ENST00000339876.10	exon30	c.C3564T	p.D1188D	exonic	ENSG00000163531.15	.	synonymous SNV	ENSG00000163531.15:ENST00000339876.10:exon30:c.C3564T:p.D1188D	1q32.1	C3L-01124	5.765e-05	0	0	0.0006	0	1.498e-05	0.0011	0	rs765412087	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NFASC	305	0	278	21	0.0702341137123746	TRUE	NA
ENSG00000143643.13	.	BCM	GRCh38.p13	chr1	230906977	230906977	+	C	C	A	Silent	SNP	ENST00000366661.9	exon23	c.G2511T	p.T837T	exonic	ENSG00000143643.13	.	synonymous SNV	ENSG00000143643.13:ENST00000366661.9:exon23:c.G2511T:p.T837T	1q42.2	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TTC13	93	0	71	4	0.0533333333333333	TRUE	TRUE
ENSG00000012171.20	.	BCM	GRCh38.p13	chr3	50275358	50275358	+	C	C	T	Silent	SNP	ENST00000616701.5	exon14	c.C1548T	p.C516C	exonic	ENSG00000012171.20	.	synonymous SNV	ENSG00000012171.20:ENST00000616701.5:exon14:c.C1548T:p.C516C	3p21.31	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEMA3B	193	0	148	8	0.0512820512820513	TRUE	TRUE
ENSG00000169862.19	.	BCM	GRCh38.p13	chr5	11117555	11117555	+	C	C	T	Silent	SNP	ENST00000304623.13	exon13	c.G2172A	p.S724S	exonic	ENSG00000169862.19	.	synonymous SNV	ENSG00000169862.19:ENST00000304623.13:exon13:c.G2172A:p.S724S	5p15.2	C3L-01124	8.243e-06	0	0	0	0	1.5e-05	0	0	rs775044101	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTNND2	229	0	210	12	0.0540540540540541	TRUE	NA
ENSG00000038427.16	.	BCM	GRCh38.p13	chr5	83541625	83541625	+	G	G	A	Silent	SNP	ENST00000265077.8	exon8	c.G8622A	p.A2874A	exonic	ENSG00000038427.16	.	synonymous SNV	ENSG00000038427.16:ENST00000265077.8:exon8:c.G8622A:p.A2874A	5q14.3	C3L-01124	0.0038	0.0401	0.0032	0	0	0.0001	0.0022	6.062e-05	rs3096171	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VCAN	196	1	134	12	0.0821917808219178	TRUE	NA
ENSG00000185274.12	.	BCM	GRCh38.p13	chr7	71415935	71415935	+	C	C	T	Silent	SNP	ENST00000333538.10	exon4	c.C636T	p.P212P	exonic	ENSG00000185274.12	.	synonymous SNV	ENSG00000185274.12:ENST00000333538.10:exon4:c.C636T:p.P212P	7q11.22	C3L-01124	2.485e-05	9.647e-05	8.658e-05	0.0001	0	0	0	0	rs371536707	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GALNT17	73	0	71	11	0.134146341463415	TRUE	NA
ENSG00000175877.4	.	BCM	GRCh38.p13	chr7	73865421	73865421	+	G	G	A	Silent	SNP	ENST00000320531.3	exon2	c.G501A	p.K167K	exonic	ENSG00000175877.4	.	synonymous SNV	ENSG00000175877.4:ENST00000320531.3:exon2:c.G501A:p.K167K	7q11.23	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM270	105	0	63	10	0.136986301369863	TRUE	TRUE
ENSG00000196275.14	.	BCM	GRCh38.p13	chr7	74797727	74797727	+	G	G	T	Silent	SNP	ENST00000451013.6	exon16	c.C1785A	p.I595I	exonic	ENSG00000196275.14	.	synonymous SNV	ENSG00000196275.14:ENST00000451013.6:exon16:c.C1785A:p.I595I	7q11.23	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63100034;OCCURENCE=3(endometrium)	GTF2IRD2	229	0	168	18	0.0967741935483871	NA	TRUE
ENSG00000283787.1	.	BCM	GRCh38.p13	chr11	1890342	1890342	+	C	C	T	Silent	SNP	ENST00000640310.1	exon1	c.G243A	p.P81P	exonic	ENSG00000283787.1	.	synonymous SNV	ENSG00000283787.1:ENST00000640310.1:exon1:c.G243A:p.P81P	11p15.5	C3L-01124	.	.	.	.	.	.	.	.	rs866562938	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100289020;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	PRR33	138	0	136	8	0.0555555555555556	TRUE	NA
ENSG00000171817.17	.	BCM	GRCh38.p13	chr19	37611925	37611925	+	T	T	C	Silent	SNP	ENST00000316433.9	exon5	c.T645C	p.C215C	exonic	ENSG00000171817.17	.	synonymous SNV	ENSG00000171817.17:ENST00000316433.9:exon5:c.T645C:p.C215C	19q13.12	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF540	198	0	151	11	0.0679012345679012	TRUE	TRUE
ENSG00000101158.15	.	BCM	GRCh38.p13	chr20	58991341	58991341	+	C	C	T	Silent	SNP	ENST00000652272.2	exon9	c.C984T	p.F328F	exonic	ENSG00000101158.15	.	synonymous SNV	ENSG00000101158.15:ENST00000652272.2:exon9:c.C984T:p.F328F	20q13.32	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NELFCD	220	0	223	18	0.0746887966804979	TRUE	TRUE
ENSG00000075340.23	.	BCM	GRCh38.p13	chr2	70673273	70673273	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000075340.23	.	.	.	2p13.3	C3L-01124	.	.	.	.	.	.	.	.	.	2.16	D	D	B	B	.	N	.	T	N	0.102	T	T	T	0.002	0.384	0.110	.	.	.	T	T	T	T	0.337	4.720	0.951	N	N	-1.094	0.312	-1.231	0.258	0.987	0.537	0.590	0.490	0.542	.	3.210	-2.930	-0.172	-0.774	0.502	0.002	0.001	0.006	754	.	.	.	.	ADD2	293	0	284	15	0.0501672240802676	TRUE	NA
ENSG00000092108.21	.	BCM	GRCh38.p13	chr14	30644007	30644007	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000092108.21	.	.	.	14q12	C3L-01124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCFD1	210	0	207	21	0.0921052631578947	TRUE	NA
ENSG00000143207.21	.	BCM	GRCh38.p13	chr1	176206867	176206867	+	G	G	A	Missense_Mutation	SNP	ENST00000367669.8	exon1	c.C112T	p.P38S	exonic	ENSG00000143207.21	.	nonsynonymous SNV	ENSG00000143207.21:ENST00000367669.8:exon1:c.C112T:p.P38S	1q25.2	C3N-02592	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	N	.	T	N	0.366	T	T	D	0.083	0.112	0.281	0.800	D	T	T	T	T	T	2.486	22.400	0.997	N	N	-0.285	1.652	-0.118	1.998	1.000	0.442	0.522	0.522	0.581	.	3.910	3.910	1.374	1.084	0.566	1.000	0.999	0.975	860	.	.	.	.	COP1	103	0	173	18	0.0942408376963351	TRUE	TRUE
ENSG00000162923.16	.	BCM	GRCh38.p13	chr1	224433703	224433703	+	A	A	T	Missense_Mutation	SNP	ENST00000651911.1	exon1	c.T403A	p.L135M	exonic	ENSG00000162923.16	.	nonsynonymous SNV	ENSG00000162923.16:ENST00000651911.1:exon1:c.T403A:p.L135M	1q42.12	C3N-02592	.	.	.	.	.	.	.	.	.	13.17	D	D	.	.	.	D	M	D	N	0.513	D	D	D	0.590	0.574	0.272	2.229	D	T	D	T	D	D	3.477	24.600	0.993	D	N	0.198	3.293	0.154	2.969	1.000	0.733	0.522	0.601	0.562	.	3.840	2.700	3.165	0.252	0.756	1.000	1.000	1.000	749	LIS1_homology_motif	.	.	.	WDR26	78	0	177	11	0.0585106382978723	TRUE	TRUE
ENSG00000154358.21	.	BCM	GRCh38.p13	chr1	228245431	228245431	+	C	C	T	Missense_Mutation	SNP	ENST00000422127.5	exon12	c.C3500T	p.A1167V	exonic	ENSG00000154358.21	.	nonsynonymous SNV	ENSG00000154358.21:ENST00000422127.5:exon12:c.C3500T:p.A1167V	1q42.13	C3N-02592	4.998e-05	0.0001	0.0002	0	0	1.504e-05	0	0.0001	rs377738173	4.20	T	T	D	D	N	D	N	T	N	0.185	T	T	D	0.073	.	0.662	0.105	T	T	T	T	T	T	0.921	10.660	0.992	N	N	-0.369	1.451	-0.492	1.214	0.236	0.719	0.574	0.723	0.564	.	4.200	2.310	0.123	0.048	-0.379	0.001	0.015	0.003	459	Immunoglobulin-like_domain	.	.	.	OBSCN	115	0	200	19	0.0867579908675799	TRUE	NA
ENSG00000135801.9	.	BCM	GRCh38.p13	chr1	229594644	229594644	+	C	C	T	Missense_Mutation	SNP	ENST00000258281.6	exon5	c.G1423A	p.A475T	exonic	ENSG00000135801.9	.	nonsynonymous SNV	ENSG00000135801.9:ENST00000258281.6:exon5:c.G1423A:p.A475T	1q42.13	C3N-02592	.	.	.	.	.	.	.	.	.	9.20	T	D	P	B	D	D	L	T	D	0.670	T	T	D	0.343	0.655	0.645	1.705	T	T	D	T	D	T	2.473	22.300	0.998	D	D	-0.007	2.486	-0.008	2.331	1.000	0.707	0.654	0.725	0.636	.	5.970	4.070	6.147	0.074	0.599	1.000	0.161	0.193	520	WD40-repeat-containing_domain	.	.	.	TAF5L	193	0	469	26	0.0525252525252525	TRUE	NA
ENSG00000151779.13	.	BCM	GRCh38.p13	chr2	15234720	15234720	+	A	A	T	Missense_Mutation	SNP	ENST00000281513.10	exon46	c.T5971A	p.Y1991N	exonic	ENSG00000151779.13	.	nonsynonymous SNV	ENSG00000151779.13:ENST00000281513.10:exon46:c.T5971A:p.Y1991N	2p24.3	C3N-02592	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.963	T	T	D	0.587	0.559	0.837	0.328	T	T	D	D	D	D	4.182	28.500	0.990	D	D	0.775	8.315	0.760	9.040	1.000	0.732	0.744	0.710	0.613	.	5.570	5.570	8.027	1.312	0.756	1.000	0.993	0.993	935	.	.	.	.	NBAS	225	0	432	28	0.0608695652173913	TRUE	TRUE
ENSG00000153246.13	.	BCM	GRCh38.p13	chr2	159967627	159967627	+	C	C	T	Missense_Mutation	SNP	ENST00000283243.13	exon20	c.G2816A	p.R939Q	exonic	ENSG00000153246.13	.	nonsynonymous SNV	ENSG00000153246.13:ENST00000283243.13:exon20:c.G2816A:p.R939Q	2q24.2	C3N-02592	2.473e-05	0	8.651e-05	0	0	0	0	0.0001	rs199979054	12.20	D	D	D	D	D	D	M	T	D	0.700	T	T	D	0.222	.	0.510	0.421	T	T	T	T	D	D	3.604	25.100	1.000	D	N	0.483	4.905	0.396	4.333	0.931	0.732	0.547	0.602	0.728	.	5.670	3.840	3.268	1.026	0.599	1.000	0.961	0.872	640	C-type_lectin-like	.	.	ID=COSV51775194;OCCURENCE=1(large_intestine),1(skin)	PLA2R1	166	0	320	37	0.103641456582633	TRUE	TRUE
ENSG00000144644.14	.	BCM	GRCh38.p13	chr3	30801025	30801025	+	C	C	A	Missense_Mutation	SNP	ENST00000282538.9	exon12	c.G1114T	p.D372Y	exonic	ENSG00000144644.14	.	nonsynonymous SNV	ENSG00000144644.14:ENST00000282538.9:exon12:c.G1114T:p.D372Y	3p23	C3N-02592	0.0014	0.0138	0.0011	0	0	0.0002	0.0022	6.057e-05	rs61738477	12.19	D	D	D	D	D	D	H	T	D	0.965	T	T	.	0.561	.	0.460	0.057	D	T	T	T	T	D	4.021	27.100	0.996	D	D	0.962	12.765	0.894	13.483	1.000	0.554	0.590	0.602	0.542	.	5.470	5.470	7.568	1.026	0.549	1.000	0.988	0.977	845	.	.	.	.	GADL1	297	0	558	34	0.0574324324324324	TRUE	NA
ENSG00000183090.5	.	BCM	GRCh38.p13	chr4	143577685	143577685	+	G	G	T	Missense_Mutation	SNP	ENST00000329798.5	exon8	c.C6346A	p.P2116T	exonic	ENSG00000183090.5	.	nonsynonymous SNV	ENSG00000183090.5:ENST00000329798.5:exon8:c.C6346A:p.P2116T	4q31.21	C3N-02592	.	.	.	.	.	.	.	.	.	9.18	D	D	.	.	D	D	L	T	D	0.473	T	T	T	0.308	0.498	0.225	.	T	T	T	T	D	D	3.485	24.700	0.997	D	D	0.407	4.384	0.405	4.394	0.999	0.554	0.574	0.574	0.568	.	3.740	3.740	9.391	1.176	0.676	1.000	0.997	0.993	816	.	.	.	.	FREM3	173	0	372	35	0.085995085995086	TRUE	TRUE
ENSG00000112685.14	.	BCM	GRCh38.p13	chr6	564072	564072	+	C	C	G	Missense_Mutation	SNP	ENST00000230449.9	exon16	c.G1750C	p.V584L	exonic	ENSG00000112685.14	.	nonsynonymous SNV	ENSG00000112685.14:ENST00000230449.9:exon16:c.G1750C:p.V584L	6p25.3	C3N-02592	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	L	T	N	0.479	T	T	T	0.044	0.426	0.247	0.178	T	T	T	T	D	T	1.777	17.560	0.991	D	D	-0.106	2.156	0.046	2.522	1.000	0.707	0.725	0.725	0.714	.	5.730	4.850	4.496	0.138	0.549	1.000	0.959	0.749	888	.	.	.	.	EXOC2	192	0	365	33	0.0829145728643216	TRUE	TRUE
ENSG00000204410.16	.	BCM	GRCh38.p13	chr6	31741250	31741250	+	G	G	A	Missense_Mutation	SNP	ENST00000375750.9	exon3	c.G235A	p.A79T	exonic	ENSG00000204410.16;ENSG00000255152.8	.	nonsynonymous SNV	ENSG00000204410.16:ENST00000375750.9:exon3:c.G235A:p.A79T,ENSG00000255152.8:ENST00000493662.6:exon3:c.G235A:p.A79T	6p21.33	C3N-02592	.	.	.	.	.	.	.	.	.	1.17	T	T	B	B	N	.	L	T	N	0.108	T	T	T	0.035	0.351	0.424	0.428	.	T	T	T	T	.	1.863	18.210	0.870	D	N	-0.430	1.319	-0.244	1.683	1.000	0.672	0.672	0.702	0.755	.	5.030	2.880	0.950	1.081	0.672	0.782	0.999	0.997	889	.	.	.	.	MSH5	145	0	289	28	0.0883280757097792	TRUE	TRUE
ENSG00000152822.14	.	BCM	GRCh38.p13	chr6	146352343	146352343	+	T	T	C	Missense_Mutation	SNP	ENST00000282753.6	exon4	c.T1280C	p.M427T	exonic	ENSG00000152822.14	.	nonsynonymous SNV	ENSG00000152822.14:ENST00000282753.6:exon4:c.T1280C:p.M427T	6q24.3	C3N-02592	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.867	D	D	D	0.936	0.729	0.881	1.860	D	D	D	D	D	D	3.718	25.500	0.994	D	D	0.920	11.580	0.877	12.797	1.000	0.487	0.574	0.547	0.613	.	5.840	5.840	8.017	1.138	0.665	1.000	0.995	0.979	240	Receptor,_ligand_binding_region	.	.	.	GRM1	549	0	895	50	0.0529100529100529	TRUE	TRUE
ENSG00000136213.10	.	BCM	GRCh38.p13	chr7	2433354	2433354	+	A	A	G	Missense_Mutation	SNP	ENST00000618655.2	exon2	c.A715G	p.T239A	exonic	ENSG00000136213.10	.	nonsynonymous SNV	ENSG00000136213.10:ENST00000618655.2:exon2:c.A715G:p.T239A	7p22.3	C3N-02592	.	.	.	.	.	.	.	.	.	15.20	T	T	D	D	D	D	M	T	N	0.835	D	D	D	0.374	0.648	0.959	1.438	T	D	D	D	D	D	3.895	26.300	0.988	D	D	0.714	7.316	0.669	7.205	0.949	0.707	0.702	0.571	0.714	.	5.270	5.270	7.331	1.207	0.756	1.000	1.000	0.997	873	.	.	.	.	CHST12	213	0	509	28	0.0521415270018622	TRUE	TRUE
ENSG00000122644.13	.	BCM	GRCh38.p13	chr7	12688720	12688720	+	C	C	G	Missense_Mutation	SNP	ENST00000651779.1	exon2	c.C466G	p.L156V	exonic	ENSG00000122644.13	.	nonsynonymous SNV	ENSG00000122644.13:ENST00000651779.1:exon2:c.C466G:p.L156V	7p21.3	C3N-02592	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	N	D	M	T	N	0.712	T	T	T	0.348	0.534	0.741	0.672	T	T	T	T	D	D	3.395	24.400	0.998	D	D	0.610	6.023	0.591	6.116	1.000	0.543	0.588	0.581	0.639	.	4.700	4.700	3.354	1.005	0.599	1.000	1.000	0.999	909	.	.	.	.	ARL4A	232	0	402	22	0.0518867924528302	NA	TRUE
ENSG00000204930.10	.	BCM	GRCh38.p13	chr9	35818929	35818929	+	C	C	T	Missense_Mutation	SNP	ENST00000650284.1	exon5	c.G145A	p.D49N	exonic	ENSG00000204930.10;ENSG00000285645.1	.	nonsynonymous SNV	ENSG00000285645.1:ENST00000650284.1:exon5:c.G145A:p.D49N,ENSG00000204930.10:ENST00000423537.7:exon6:c.G1132A:p.D378N	9p13.3	C3N-02592	.	.	.	.	.	.	.	.	.	6.19	D	D	B	B	.	D	N	T	N	0.223	T	T	T	0.087	0.345	0.072	0.064	T	T	T	T	D	T	2.821	23.100	0.998	D	D	-0.080	2.237	0.072	2.623	1.000	0.554	0.588	0.547	0.542	.	5.420	5.420	4.466	1.026	0.599	1.000	0.936	0.424	146	.	.	.	.	FAM221B	289	0	3124	494	0.136539524599226	TRUE	TRUE
ENSG00000137103.20	.	BCM	GRCh38.p13	chr9	35846847	35846847	+	C	C	A	Missense_Mutation	SNP	ENST00000377991.9	exon11	c.C671A	p.A224E	exonic	ENSG00000137103.20	.	nonsynonymous SNV	ENSG00000137103.20:ENST00000377991.9:exon11:c.C671A:p.A224E	9p13.3	C3N-02592	.	.	.	.	.	.	.	.	.	9.20	D	D	P	B	N	D	L	D	N	0.461	D	D	D	0.209	0.351	0.483	0.701	T	T	T	T	D	T	2.327	21.700	0.956	D	N	-0.253	1.734	-0.166	1.869	1.000	0.767	0.688	0.851	0.601	.	6.170	3.240	3.297	0.103	-0.223	0.995	0.946	0.991	164	.	.	.	.	TMEM8B	112	0	1053	430	0.289952798381659	TRUE	TRUE
ENSG00000173679.2	.	BCM	GRCh38.p13	chr9	122661863	122661863	+	C	C	T	Missense_Mutation	SNP	ENST00000373686.1	exon1	c.C298T	p.R100C	exonic	ENSG00000173679.2	.	nonsynonymous SNV	ENSG00000173679.2:ENST00000373686.1:exon1:c.C298T:p.R100C	9q33.2	C3N-02592	8.237e-05	0	0.0004	0	0.0002	5.994e-05	0	0	rs747195797	0.19	T	T	B	B	.	N	L	T	N	0.095	T	T	T	0.006	0.431	0.484	0.042	T	T	T	T	T	T	0.526	6.773	0.588	N	N	-1.183	0.239	-1.231	0.258	0.137	0.487	0.574	0.574	0.530	.	3.110	0.147	-5.717	0.936	0.524	0.000	0.077	0.011	950	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58935455;OCCURENCE=1(large_intestine),1(stomach)	OR1L1	164	0	248	29	0.104693140794224	TRUE	TRUE
ENSG00000181609.5	.	BCM	GRCh38.p13	chr11	5488743	5488743	+	G	G	T	Missense_Mutation	SNP	ENST00000322641.5	exon1	c.G37T	p.D13Y	exonic	ENSG00000181609.5	.	nonsynonymous SNV	ENSG00000181609.5:ENST00000322641.5:exon1:c.G37T:p.D13Y	11p15.4	C3N-02592	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.173	T	T	T	0.032	0.308	0.175	0.004	T	T	T	T	T	T	0.706	8.506	0.677	N	N	-0.826	0.617	-0.836	0.708	1.000	0.487	0.574	0.574	0.564	.	5.380	1.120	-0.056	0.207	-0.244	0.001	0.008	0.007	704	.	.	.	.	OR52D1	102	0	195	14	0.0669856459330144	TRUE	TRUE
ENSG00000248746.6	.	BCM	GRCh38.p13	chr11	66556222	66556222	+	G	G	A	Missense_Mutation	SNP	ENST00000513398.2	exon8	c.G796A	p.A266T	exonic	ENSG00000248746.6	.	nonsynonymous SNV	ENSG00000248746.6:ENST00000513398.2:exon8:c.G796A:p.A266T	11q13.2	C3N-02592	.	.	.	.	.	.	.	.	.	5.10	.	T	B	B	.	.	.	.	.	0.667	.	.	.	.	.	0.564	.	T	T	D	D	.	D	3.486	24.700	0.998	D	D	.	.	.	.	0.967	0.257	0.061	0.320	0.059	.	4.670	4.670	8.136	1.176	0.676	1.000	1.000	0.998	59	.	.	.	ID=COSV72207675;OCCURENCE=1(endometrium)	ACTN3	65	0	181	24	0.117073170731707	TRUE	TRUE
ENSG00000162337.12	.	BCM	GRCh38.p13	chr11	68425169	68425169	+	G	G	A	Missense_Mutation	SNP	ENST00000294304.12	exon15	c.G3304A	p.E1102K	exonic	ENSG00000162337.12	.	nonsynonymous SNV	ENSG00000162337.12:ENST00000294304.12:exon15:c.G3304A:p.E1102K	11q13.2	C3N-02592	.	.	.	.	.	.	.	.	rs970458513	18.20	D	D	D	P	U	D	M	D	D	0.959	D	D	D	0.945	0.648	0.973	1.061	D	D	D	D	D	D	4.236	29.000	0.999	D	D	0.688	6.958	0.680	7.387	1.000	0.707	0.725	0.723	0.714	.	4.930	4.930	9.337	1.176	0.618	1.000	0.911	0.790	730	.	.	.	ID=COSV53723710;OCCURENCE=1(urinary_tract)	LRP5	189	0	370	28	0.0703517587939698	TRUE	TRUE
ENSG00000134909.18	.	BCM	GRCh38.p13	chr11	128969401	128969402	+	CA	CA	-	Frame_Shift_Del	DEL	ENST00000310343.13	exon22	c.5769_5770del	p.G1924Sfs*30	exonic	ENSG00000134909.18	.	frameshift deletion	ENSG00000134909.18:ENST00000310343.13:exon22:c.5769_5770del:p.G1924Sfs*30	11q24.3	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARHGAP32	276	0	529	49	0.0847750865051903	NA	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-02592	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	219	0	504	52	0.0935251798561151	TRUE	TRUE
ENSG00000211455.8	.	BCM	GRCh38.p13	chr12	27315321	27315321	+	G	G	A	Missense_Mutation	SNP	ENST00000389032.8	exon9	c.G808A	p.E270K	exonic	ENSG00000211455.8	.	nonsynonymous SNV	ENSG00000211455.8:ENST00000389032.8:exon9:c.G808A:p.E270K	12p11.23	C3N-02592	.	.	.	.	.	.	.	.	.	9.20	T	T	P	P	D	D	N	T	N	0.593	T	T	T	0.425	0.440	0.609	1.516	D	T	D	D	D	D	3.942	26.600	0.999	D	D	0.161	3.134	0.261	3.496	1.000	0.706	0.725	0.710	0.714	.	4.500	3.600	9.925	1.157	0.595	1.000	0.996	0.998	787	Protein_kinase_domain	.	.	.	STK38L	92	0	169	35	0.17156862745098	TRUE	TRUE
ENSG00000092054.13	.	BCM	GRCh38.p13	chr14	23416063	23416063	+	C	C	T	Missense_Mutation	SNP	ENST00000355349.4	exon34	c.G4894A	p.A1632T	exonic	ENSG00000092054.13	.	nonsynonymous SNV	ENSG00000092054.13:ENST00000355349.4:exon34:c.G4894A:p.A1632T	14q11.2	C3N-02592	4.118e-05	0.0002	8.637e-05	0	0	1.498e-05	0	6.056e-05	rs565663412	14.19	D	D	P	P	.	D	M	T	D	0.759	D	D	D	0.637	0.513	0.963	1.522	T	D	T	D	D	D	3.498	24.700	0.999	D	D	0.656	6.550	0.622	6.514	1.000	0.549	0.627	0.578	0.542	.	4.550	4.550	5.691	0.935	0.526	1.000	0.796	0.884	384	Myosin_tail	.	.	ID=COSV62518371;OCCURENCE=1(prostate)	MYH7	339	0	700	45	0.0604026845637584	NA	TRUE
ENSG00000103326.12	.	BCM	GRCh38.p13	chr16	547193	547193	+	G	G	A	Missense_Mutation	SNP	ENST00000219611.7	exon4	c.G355A	p.A119T	exonic	ENSG00000103326.12	.	nonsynonymous SNV	ENSG00000103326.12:ENST00000219611.7:exon4:c.G355A:p.A119T	16p13.3	C3N-02592	6.036e-05	0	0	0	0	0	0	0.0004	rs560874988	3.20	T	T	B	B	N	N	L	D	N	0.203	T	T	D	0.217	0.119	0.332	.	T	T	T	T	T	T	0.609	7.597	0.889	D	N	-1.130	0.281	-1.098	0.378	1.000	0.778	0.698	0.854	0.630	.	4.930	1.830	0.952	-0.225	0.674	0.001	0.000	0.005	798	.	.	.	.	CAPN15	76	0	127	11	0.0797101449275362	TRUE	NA
ENSG00000149930.18	.	BCM	GRCh38.p13	chr16	29981908	29981908	+	C	C	T	Nonsense_Mutation	SNP	ENST00000308893.9	exon10	c.C799T	p.Q267X	exonic	ENSG00000149930.18	.	stopgain	ENSG00000149930.18:ENST00000308893.9:exon10:c.C799T:p.Q267X	16p11.2	C3N-02592	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.558	.	.	.	.	.	.	.	.	.	D	D	.	.	7.336	37	0.998	D	N	1.219	25.499	1.091	26.101	1.000	0.732	0.725	0.744	0.714	.	5.910	5.910	7.826	1.026	0.599	1.000	1.000	1.000	82	Protein_kinase_domain	.	.	.	TAOK2	202	0	446	26	0.0550847457627119	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673802	7673802	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G818A	p.R273H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G818A:p.R273H	17p13.1	C3N-02592	2.628e-05	0	0	0	0	4.746e-05	0	0	rs28934576	19.20	D	D	D	D	D	A	M	D	D	0.965	D	D	D	0.868	.	0.997	0.264	T	D	D	D	D	D	3.527	24.800	0.998	D	D	0.383	4.238	0.333	3.915	1.000	0.722	0.702	0.725	0.735	.	4.920	4.920	7.905	1.022	0.596	1.000	0.856	0.980	432	p53,_DNA-binding_domain	.	.	ID=COSV52660980;OCCURENCE=3(salivary_gland),135(breast),5(penis),9(liver),2(genital_tract),55(oesophagus),3(adrenal_gland),1(cervix),301(large_intestine),84(central_nervous_system),18(biliary_tract),1(fallopian_tube),1(pleura),4(vulva),73(ovary),8(bone),6(NS),57(haematopoietic_and_lymphoid_tissue),60(stomach),23(urinary_tract),7(soft_tissue),9(kidney),55(pancreas),15(skin),22(prostate),111(lung),11(thyroid),66(upper_aerodigestive_tract),2(thymus),41(endometrium)	TP53	490	1	842	107	0.112750263435195	TRUE	TRUE
ENSG00000099331.13	.	BCM	GRCh38.p13	chr19	17163108	17163108	+	T	T	G	Missense_Mutation	SNP	ENST00000594824.5	exon10	c.T1657G	p.F553V	exonic	ENSG00000099331.13	.	nonsynonymous SNV	ENSG00000099331.13:ENST00000594824.5:exon10:c.T1657G:p.F553V	19p13.11	C3N-02592	.	.	.	.	.	.	.	.	.	18.18	D	D	.	.	D	D	M	D	D	0.802	D	D	D	0.963	0.859	0.936	2.040	D	D	D	D	D	D	4.270	29.300	0.993	D	D	0.866	10.200	0.774	9.389	1.000	0.707	0.702	0.725	0.714	.	5.060	5.060	7.926	1.036	0.661	1.000	0.995	0.986	923	Class_IX_myosin,_motor_domain;Myosin_head,_motor_domain	.	.	.	MYO9B	131	0	299	17	0.0537974683544304	TRUE	TRUE
ENSG00000197408.10	.	BCM	GRCh38.p13	chr19	40991360	40991360	+	C	C	A	Missense_Mutation	SNP	ENST00000324071.10	exon1	c.C55A	p.L19M	exonic	ENSG00000197408.10	.	nonsynonymous SNV	ENSG00000197408.10:ENST00000324071.10:exon1:c.C55A:p.L19M	19q13.2	C3N-02592	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.221	T	T	T	0.065	0.438	0.330	0.064	T	T	T	T	T	T	-1.147	0.003	0.511	N	N	-1.401	0.116	-1.533	0.096	0.024	0.487	0.574	0.573	0.564	.	2.920	-5.390	-2.257	-0.743	-0.242	0.000	0.001	0.005	825	.	.	.	.	CYP2B6	420	0	746	53	0.0663329161451815	TRUE	TRUE
ENSG00000185052.12	.	BCM	GRCh38.p13	chr20	19684187	19684187	+	C	C	T	Missense_Mutation	SNP	ENST00000328041.11	exon11	c.C913T	p.R305C	exonic	ENSG00000185052.12	.	nonsynonymous SNV	ENSG00000185052.12:ENST00000328041.11:exon11:c.C913T:p.R305C	20p11.23	C3N-02592	2.475e-05	0	0	0	0	4.5e-05	0	0	rs759715523	5.20	T	T	B	B	D	D	L	T	N	0.314	T	T	D	0.182	.	0.200	0.680	T	T	T	T	T	D	2.864	23.100	0.995	D	N	-0.087	2.218	0.093	2.706	0.021	0.615	0.547	0.659	0.530	.	5.200	5.200	2.454	1.026	0.597	1.000	1.000	0.991	833	.	.	.	ID=COSV60127832;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	SLC24A3	145	0	237	13	0.052	TRUE	TRUE
ENSG00000124194.16	.	BCM	GRCh38.p13	chr20	44279227	44279227	+	C	C	T	Missense_Mutation	SNP	ENST00000342560.9	exon6	c.C1031T	p.A344V	exonic	ENSG00000124194.16	.	nonsynonymous SNV	ENSG00000124194.16:ENST00000342560.9:exon6:c.C1031T:p.A344V	20q13.12	C3N-02592	2.475e-05	0.0002	0	0.0001	0	0	0	0	rs140997304	17.20	D	D	D	D	D	D	N	D	N	0.749	D	D	D	0.654	.	0.957	1.030	D	T	D	D	D	D	3.751	25.600	0.999	D	D	0.581	5.739	0.618	6.459	1.000	0.706	0.590	0.710	0.564	.	5.140	5.140	7.416	0.947	0.549	1.000	0.989	0.956	523	.	.	.	ID=COSV61156196;OCCURENCE=1(oesophagus),2(large_intestine),2(stomach),1(endometrium)	GDAP1L1	222	0	454	26	0.0541666666666667	TRUE	TRUE
ENSG00000120498.13	.	BCM	GRCh38.p13	chrX	70860901	70860901	+	C	C	T	Missense_Mutation	SNP	ENST00000395889.6	exon6	c.G325A	p.E109K	exonic	ENSG00000120498.13	.	nonsynonymous SNV	ENSG00000120498.13:ENST00000395889.6:exon6:c.G325A:p.E109K	Xq13.1	C3N-02592	.	.	.	.	.	.	.	.	.	1.19	T	T	P	B	N	N	L	T	N	0.181	T	T	T	0.058	0.419	0.174	0.344	T	T	T	T	T	T	1.961	18.960	0.995	D	.	.	.	.	.	0.002	.	.	.	.	.	4.830	4.830	1.774	1.008	0.599	0.981	0.144	0.850	225	.	.	.	.	TEX11	106	0	198	15	0.0704225352112676	TRUE	TRUE
ENSG00000156920.11	.	BCM	GRCh38.p13	chrX	136351540	136351540	+	C	C	T	Missense_Mutation	SNP	ENST00000394143.6	exon7	c.C6821T	p.S2274L	exonic	ENSG00000156920.11	.	nonsynonymous SNV	ENSG00000156920.11:ENST00000394143.6:exon7:c.C6821T:p.S2274L	Xq26.3	C3N-02592	.	.	.	.	.	.	.	.	.	2.17	D	T	B	B	.	D	.	T	N	0.318	T	T	T	0.033	0.386	0.095	0.032	T	T	T	T	T	T	2.671	22.800	0.997	N	.	.	.	.	.	0.999	.	.	.	.	.	4.330	3.450	1.879	0.224	-0.111	1.000	0.999	0.991	810	.	.	.	ID=COSV54956046;OCCURENCE=1(central_nervous_system),1(skin),3(endometrium)	ADGRG4	86	1	109	11	0.0916666666666667	TRUE	TRUE
ENSG00000102195.10	.	BCM	GRCh38.p13	chrX	151180610	151180610	+	C	C	T	Missense_Mutation	SNP	ENST00000218316.4	exon2	c.C1027T	p.R343C	exonic	ENSG00000102195.10	.	nonsynonymous SNV	ENSG00000102195.10:ENST00000218316.4:exon2:c.C1027T:p.R343C	Xq28	C3N-02592	1.148e-05	0.0001	0	0	0	0	0	0	rs764731190	3.19	T	D	D	P	N	N	L	T	N	0.215	T	T	D	0.190	0.416	0.736	0.531	T	T	T	T	T	T	2.921	23.300	0.998	N	.	.	.	.	.	0.995	.	.	.	.	.	3.900	2.930	1.335	-0.265	-0.222	0.001	0.000	0.000	924	.	.	.	.	GPR50	202	0	388	65	0.143487858719647	TRUE	NA
ENSG00000117523.16	.	BCM	GRCh38.p13	chr1	171540625	171540625	+	A	A	G	Silent	SNP	ENST00000367742.7	exon16	c.A3159G	p.E1053E	exonic	ENSG00000117523.16	.	synonymous SNV	ENSG00000117523.16:ENST00000367742.7:exon16:c.A3159G:p.E1053E	1q24.3	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRRC2C	186	2	486	28	0.0544747081712062	TRUE	TRUE
ENSG00000081248.11	.	BCM	GRCh38.p13	chr1	201062033	201062033	+	G	G	A	Silent	SNP	ENST00000362061.4	exon24	c.C2964T	p.R988R	exonic	ENSG00000081248.11	.	synonymous SNV	ENSG00000081248.11:ENST00000362061.4:exon24:c.C2964T:p.R988R	1q32.1	C3N-02592	2.514e-05	0	0	0.0001	0	3.036e-05	0	0	rs778128095	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62938764;OCCURENCE=1(large_intestine)	CACNA1S	520	0	1134	62	0.0518394648829431	TRUE	NA
ENSG00000084676.15	.	BCM	GRCh38.p13	chr2	24768250	24768250	+	C	C	T	Silent	SNP	ENST00000406961.5	exon23	c.C4185T	p.D1395D	exonic	ENSG00000084676.15	.	synonymous SNV	ENSG00000084676.15:ENST00000406961.5:exon23:c.C4185T:p.D1395D	2p23.3	C3N-02592	8.25e-06	0	8.645e-05	0	0	0	0	0	rs774491757	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56051786;OCCURENCE=1(large_intestine)	NCOA1	67	0	194	11	0.0536585365853659	TRUE	NA
ENSG00000178021.11	.	BCM	GRCh38.p13	chr2	54255582	54255582	+	C	C	A	Silent	SNP	ENST00000317802.9	exon1	c.G570T	p.G190G	exonic	ENSG00000178021.11	.	synonymous SNV	ENSG00000178021.11:ENST00000317802.9:exon1:c.G570T:p.G190G	2p16.2	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TSPYL6	289	0	518	66	0.113013698630137	TRUE	TRUE
ENSG00000149256.16	.	BCM	GRCh38.p13	chr11	79069897	79069897	+	G	G	A	Silent	SNP	ENST00000278550.12	exon5	c.C48T	p.R16R	exonic	ENSG00000149256.16	.	synonymous SNV	ENSG00000149256.16:ENST00000278550.12:exon5:c.C48T:p.R16R	11q14.1	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TENM4	201	0	416	52	0.111111111111111	TRUE	NA
ENSG00000161849.3	.	BCM	GRCh38.p13	chr12	52378094	52378094	+	G	G	A	Silent	SNP	ENST00000257951.3	exon9	c.C1743T	p.G581G	exonic	ENSG00000161849.3	.	synonymous SNV	ENSG00000161849.3:ENST00000257951.3:exon9:c.C1743T:p.G581G	12q13.13	C3N-02592	3.75e-05	0	0	0.0002	0	2.967e-05	0	0	rs748995346	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99230703;OCCURENCE=1(central_nervous_system)	KRT84	38	0	102	7	0.0642201834862385	TRUE	NA
ENSG00000182175.14	.	BCM	GRCh38.p13	chr15	93045280	93045280	+	G	G	A	Silent	SNP	ENST00000557301.2	exon4	c.C1095T	p.Y365Y	exonic	ENSG00000182175.14	.	synonymous SNV	ENSG00000182175.14:ENST00000557301.2:exon4:c.C1095T:p.Y365Y	15q26.1	C3N-02592	2.625e-05	0	0	0	0	0	0.0012	0.0001	rs372399863	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61233015;OCCURENCE=1(stomach)	RGMA	247	0	515	30	0.055045871559633	TRUE	TRUE
ENSG00000197647.11	.	BCM	GRCh38.p13	chr19	12015406	12015406	+	G	G	A	Silent	SNP	ENST00000344980.10	exon4	c.C1461T	p.F487F	exonic	ENSG00000197647.11	.	synonymous SNV	ENSG00000197647.11:ENST00000344980.10:exon4:c.C1461T:p.F487F	19p13.2	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF433	209	0	354	41	0.10379746835443	TRUE	TRUE
ENSG00000196961.12	.	BCM	GRCh38.p13	chr19	49792031	49792031	+	G	G	T	Silent	SNP	ENST00000359032.9	exon5	c.G570T	p.A190A	exonic	ENSG00000196961.12	.	synonymous SNV	ENSG00000196961.12:ENST00000359032.9:exon5:c.G570T:p.A190A	19q13.33	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AP2A1	245	0	465	27	0.0548780487804878	TRUE	TRUE
ENSG00000018869.16	.	BCM	GRCh38.p13	chr19	56384655	56384655	+	C	C	T	Silent	SNP	ENST00000301310.8	exon5	c.G762A	p.P254P	exonic	ENSG00000018869.16	.	synonymous SNV	ENSG00000018869.16:ENST00000301310.8:exon5:c.G762A:p.P254P	19q13.43	C3N-02592	5.773e-05	9.634e-05	0	0	0	9.002e-05	0	0	rs200288756	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF582	144	0	258	14	0.0514705882352941	TRUE	NA
ENSG00000056998.20	.	BCM	GRCh38.p13	chrX	2853980	2853980	+	G	G	A	Silent	SNP	ENST00000381163.7	exon5	c.G243A	p.R81R	exonic	ENSG00000056998.20	.	synonymous SNV	ENSG00000056998.20:ENST00000381163.7:exon5:c.G243A:p.R81R	Xp22.33	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GYG2	98	0	184	14	0.0707070707070707	TRUE	TRUE
ENSG00000180815.14	.	BCM	GRCh38.p13	chrX	19372782	19372782	+	C	C	T	Silent	SNP	ENST00000338883.8	exon22	c.G2979A	p.S993S	exonic	ENSG00000180815.14	.	synonymous SNV	ENSG00000180815.14:ENST00000338883.8:exon22:c.G2979A:p.S993S	Xp22.12	C3N-02592	1.156e-05	0	0	0	0	2.101e-05	0	0	rs150181853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58838067;OCCURENCE=1(endometrium)	MAP3K15	155	0	229	16	0.0653061224489796	TRUE	TRUE
ENSG00000102387.15	.	BCM	GRCh38.p13	chrX	101292977	101292977	+	C	C	T	Silent	SNP	ENST00000372907.7	exon1	c.G69A	p.S23S	exonic	ENSG00000102387.15	.	synonymous SNV	ENSG00000102387.15:ENST00000372907.7:exon1:c.G69A:p.S23S	Xq22.1	C3N-02592	1.153e-05	0	0	0	0	2.108e-05	0	0	rs746941333	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TAF7L	365	0	614	79	0.113997113997114	TRUE	NA
ENSG00000049883.15	.	BCM	GRCh38.p13	chr5	72320530	72320530	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000049883.15	.	.	.	5q13.2	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTCD2	223	0	384	26	0.0634146341463415	TRUE	NA
ENSG00000196301.3	.	BCM	GRCh38.p13	chr6	32460052	32460052	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000196301.3	.	.	.	6p21.32	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HLA-DRB9	149	0	293	28	0.0872274143302181	TRUE	NA
ENSG00000213930.12	.	BCM	GRCh38.p13	chr9	34647409	34647409	+	T	T	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000213930.12;ENSG00000258728.1	.	.	.	9p13.3	C3N-02592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GALT	440	0	820	362	0.306260575296108	TRUE	NA
ENSG00000140937.14	.	BCM	GRCh38.p13	chr16	64948752	64948752	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000140937.14	.	.	.	16q21	C3N-02592	.	.	.	.	.	.	.	.	.	0.16	T	T	B	B	.	N	.	T	N	0.214	T	T	T	0.049	0.399	0.453	.	.	.	T	T	T	T	0.268	3.917	0.883	N	N	-1.288	0.171	-1.393	0.155	0.908	0.560	0.574	0.574	0.550	.	3.460	-3.080	0.477	-0.215	-0.174	0.003	0.330	0.049	543	.	.	.	.	CDH11	78	0	129	23	0.151315789473684	TRUE	TRUE
ENSG00000267594.5	.	BCM	GRCh38.p13	chr19	15774300	15774300	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000267594.5	.	.	.	19p13.12	C3N-02592	3.33e-05	0	0	0.0005	0	0	0	0	rs768475662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CYP4F24P	287	0	462	56	0.108108108108108	TRUE	NA
ENSG00000187730.9	.	BCM	GRCh38.p13	chr1	2025030	2025030	+	C	C	T	Missense_Mutation	SNP	ENST00000378585.7	exon2	c.C157T	p.R53C	exonic	ENSG00000187730.9	.	nonsynonymous SNV	ENSG00000187730.9:ENST00000378585.7:exon2:c.C157T:p.R53C	1p36.33	C3N-01383	8.496e-06	0	0	0	0	1.556e-05	0	0	rs747096398	15.20	D	T	D	D	D	D	M	T	D	0.797	D	D	D	0.476	0.518	0.798	2.124	T	D	T	T	D	D	3.286	24.100	0.999	D	D	0.437	4.583	0.390	4.287	0.849	0.646	0.547	0.645	0.563	.	4.840	4.840	2.236	1.026	0.599	0.973	0.361	0.416	940	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	.	GABRD	100	1	231	16	0.0647773279352227	TRUE	NA
ENSG00000117000.9	.	BCM	GRCh38.p13	chr1	40236266	40236266	+	C	C	-	Frame_Shift_Del	DEL	ENST00000372771.5	exon8	c.1564delC	p.Q522Nfs*7	exonic	ENSG00000117000.9	.	frameshift deletion	ENSG00000117000.9:ENST00000372771.5:exon8:c.1564delC:p.Q522Nfs*7	1p34.2	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RLF	288	0	356	28	0.0729166666666667	TRUE	TRUE
ENSG00000120332.16	.	BCM	GRCh38.p13	chr1	175079569	175079569	+	G	G	A	Missense_Mutation	SNP	ENST00000239462.9	exon3	c.G646A	p.V216M	exonic	ENSG00000120332.16	.	nonsynonymous SNV	ENSG00000120332.16:ENST00000239462.9:exon3:c.G646A:p.V216M	1q25.1	C3N-01383	.	.	.	.	.	.	.	.	.	1.20	T	T	P	B	N	N	M	T	N	0.300	T	T	T	0.049	0.348	0.210	0.112	T	T	T	T	T	T	1.544	16.020	0.982	N	N	-0.336	1.528	-0.493	1.213	0.001	0.517	0.590	0.479	0.613	.	4.700	2.790	1.585	-0.132	-0.161	0.016	0.022	0.014	556	EGF-like_domain	.	.	ID=COSV53421489;OCCURENCE=1(liver),2(large_intestine)	TNN	175	0	519	41	0.0732142857142857	TRUE	TRUE
ENSG00000047410.14	.	BCM	GRCh38.p13	chr1	186362896	186362896	+	T	T	C	Missense_Mutation	SNP	ENST00000367478.9	exon6	c.A637G	p.R213G	exonic	ENSG00000047410.14	.	nonsynonymous SNV	ENSG00000047410.14:ENST00000367478.9:exon6:c.A637G:p.R213G	1q31.1	C3N-01383	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	D	D	M	T	D	0.807	T	T	D	0.256	0.290	0.379	0.473	T	T	D	T	D	D	3.502	24.700	0.996	D	N	0.433	4.556	0.392	4.301	0.988	0.732	0.744	0.725	0.728	.	5.330	4.170	1.133	1.138	0.665	1.000	1.000	0.999	305	.	.	.	.	TPR	154	0	198	19	0.0875576036866359	TRUE	NA
ENSG00000116833.14	.	BCM	GRCh38.p13	chr1	200120856	200120856	+	C	C	T	Missense_Mutation	SNP	ENST00000367362.8	exon7	c.C1279T	p.L427F	exonic	ENSG00000116833.14	.	nonsynonymous SNV	ENSG00000116833.14:ENST00000367362.8:exon7:c.C1279T:p.L427F	1q32.1	C3N-01383	.	.	.	.	.	.	.	.	.	17.20	D	D	P	P	D	D	M	D	D	0.870	D	D	D	0.813	0.660	0.951	1.087	T	D	D	D	D	D	3.707	25.400	0.999	D	D	0.554	5.484	0.600	6.224	0.998	0.615	0.547	0.659	0.621	.	5.720	5.720	4.103	1.026	0.599	1.000	1.000	0.997	895	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	NR5A2	80	0	125	12	0.0875912408759124	TRUE	TRUE
ENSG00000155816.20	.	BCM	GRCh38.p13	chr1	240178003	240178003	+	T	T	C	Missense_Mutation	SNP	ENST00000319653.14	exon3	c.T1865C	p.V622A	exonic	ENSG00000155816.20	.	nonsynonymous SNV	ENSG00000155816.20:ENST00000319653.14:exon3:c.T1865C:p.V622A	1q43	C3N-01383	.	.	.	.	.	.	.	.	.	3.20	D	D	B	B	N	N	L	T	N	0.042	T	T	D	0.263	0.130	0.582	0.111	T	T	T	T	T	T	0.596	7.477	0.725	N	N	-0.975	0.432	-1.061	0.417	0.034	0.554	0.574	0.618	0.621	.	5.520	-4.870	0.672	0.088	0.587	0.612	0.029	0.022	976	.	.	.	.	FMN2	118	0	218	12	0.0521739130434783	TRUE	NA
ENSG00000177174.1	.	BCM	GRCh38.p13	chr1	248349052	248349052	+	C	C	T	Missense_Mutation	SNP	ENST00000317861.1	exon1	c.C278T	p.A93V	exonic	ENSG00000177174.1	.	nonsynonymous SNV	ENSG00000177174.1:ENST00000317861.1:exon1:c.C278T:p.A93V	1q44	C3N-01383	0.0002	0.0002	0.0002	0	0.0002	0.0002	0	0.0004	rs145207343	0.20	T	T	B	B	N	N	L	T	N	0.053	T	T	T	0.010	.	0.014	0.159	T	T	T	T	T	T	0.695	8.410	0.868	N	N	-0.906	0.513	-0.964	0.534	0.000	0.487	0.574	0.574	0.564	.	3.900	-1.110	-2.651	0.471	0.348	0.000	0.003	0.004	982	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58600854;OCCURENCE=1(central_nervous_system)	OR14C36	264	0	455	48	0.095427435387674	TRUE	TRUE
ENSG00000186487.20	.	BCM	GRCh38.p13	chr2	1923009	1923009	+	C	C	G	Missense_Mutation	SNP	ENST00000647738.2	exon10	c.G760C	p.D254H	exonic	ENSG00000186487.20	.	nonsynonymous SNV	ENSG00000186487.20:ENST00000647738.2:exon10:c.G760C:p.D254H	2p25.3	C3N-01383	.	.	.	.	.	.	.	.	.	11.20	D	T	D	D	D	D	M	T	N	0.684	T	T	T	0.220	0.200	0.308	1.598	T	T	D	T	D	D	2.534	22.500	0.994	D	D	0.302	3.789	0.399	4.354	1.000	0.487	0.574	0.547	0.564	.	6.070	6.070	4.869	1.026	0.599	1.000	0.934	0.725	695	.	.	.	.	MYT1L	326	0	560	46	0.0759075907590759	TRUE	TRUE
ENSG00000138449.11	.	BCM	GRCh38.p13	chr2	189571729	189571729	+	C	C	T	Missense_Mutation	SNP	ENST00000261024.7	exon5	c.G500A	p.R167K	exonic	ENSG00000138449.11	.	nonsynonymous SNV	ENSG00000138449.11:ENST00000261024.7:exon5:c.G500A:p.R167K	2q32.2	C3N-01383	8.33e-06	0	0	0	0	0	0.0011	0	rs750595460	10.20	T	T	P	B	D	D	L	D	N	0.235	D	D	D	0.438	0.631	0.487	0.479	T	T	D	T	D	T	2.809	23.000	0.986	D	D	0.323	3.899	0.444	4.685	1.000	0.706	0.574	0.590	0.613	.	5.290	5.290	7.726	1.026	0.599	1.000	0.983	0.992	779	.	.	.	.	SLC40A1	269	0	411	32	0.072234762979684	TRUE	NA
ENSG00000115993.13	.	BCM	GRCh38.p13	chr2	201386346	201386346	+	T	T	A	Missense_Mutation	SNP	ENST00000332624.8	exon14	c.A1835T	p.E612V	exonic	ENSG00000115993.13	.	nonsynonymous SNV	ENSG00000115993.13:ENST00000332624.8:exon14:c.A1835T:p.E612V	2q33.1	C3N-01383	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.795	T	T	D	0.491	0.346	0.143	0.606	T	D	T	T	D	D	4.312	29.700	0.995	D	D	0.807	8.919	0.754	8.894	1.000	0.707	0.725	0.725	0.714	.	5.060	5.060	7.784	1.138	0.665	1.000	1.000	0.998	431	.	.	.	.	TRAK2	377	2	684	55	0.074424898511502	NA	TRUE
ENSG00000115657.14	.	BCM	GRCh38.p13	chr2	219210281	219210281	+	T	T	C	Missense_Mutation	SNP	ENST00000265316.9	exon18	c.A2369G	p.N790S	exonic	ENSG00000115657.14	.	nonsynonymous SNV	ENSG00000115657.14:ENST00000265316.9:exon18:c.A2369G:p.N790S	2q35	C3N-01383	8.237e-06	0	0	0	0	1.498e-05	0	0	rs199955293	2.20	T	T	B	B	N	N	N	T	D	0.146	T	T	T	0.189	0.629	0.710	0.166	T	T	T	T	T	D	1.446	15.390	0.970	N	N	-0.781	0.682	-0.663	0.953	0.995	0.707	0.698	0.644	0.714	.	4.830	2.480	0.401	0.205	0.660	0.072	0.890	0.988	546	ABC_transporter-like;AAA+_ATPase_domain	.	.	.	ABCB6	279	0	545	39	0.0667808219178082	TRUE	NA
ENSG00000072195.15	.	BCM	GRCh38.p13	chr2	219448420	219448420	+	C	C	T	Missense_Mutation	SNP	ENST00000312358.12	exon4	c.C1262T	p.P421L	exonic	ENSG00000072195.15	.	nonsynonymous SNV	ENSG00000072195.15:ENST00000312358.12:exon4:c.C1262T:p.P421L	2q35	C3N-01383	.	.	.	.	.	.	.	.	.	7.20	D	D	B	B	N	D	L	T	D	0.316	T	T	D	0.066	0.230	0.416	1.645	D	T	T	T	T	D	2.461	22.300	0.991	N	N	-0.312	1.584	-0.145	1.924	1.000	0.726	0.563	0.594	0.563	.	4.130	3.150	1.931	0.959	0.522	0.998	0.999	0.976	86	.	.	.	.	SPEG	137	0	337	33	0.0891891891891892	TRUE	TRUE
ENSG00000163359.16	.	BCM	GRCh38.p13	chr2	237334785	237334785	+	C	C	T	Missense_Mutation	SNP	ENST00000295550.9	exon41	c.G9070A	p.V3024I	exonic	ENSG00000163359.16	.	nonsynonymous SNV	ENSG00000163359.16:ENST00000295550.9:exon41:c.G9070A:p.V3024I	2q37.3	C3N-01383	1.647e-05	0	0	0	0	2.997e-05	0	0	rs769756403	0.20	T	T	B	B	N	N	L	T	N	0.136	T	T	T	0.005	.	0.214	0.119	T	T	T	T	T	T	0.364	5.021	0.873	N	N	-1.097	0.309	-1.003	0.485	0.999	0.615	0.586	0.659	0.542	.	5.230	1.990	-0.684	-0.235	-0.827	0.000	0.840	0.679	955	Fibronectin_type_III	.	.	ID=COSV55100929;OCCURENCE=2(breast),2(large_intestine),1(stomach)	COL6A3	286	1	570	61	0.0966719492868463	TRUE	TRUE
ENSG00000204099.11	.	BCM	GRCh38.p13	chr2	241815057	241815057	+	C	C	T	Missense_Mutation	SNP	ENST00000391969.6	exon4	c.C367T	p.R123C	exonic	ENSG00000204099.11	.	nonsynonymous SNV	ENSG00000204099.11:ENST00000391969.6:exon4:c.C367T:p.R123C	2q37.3	C3N-01383	7.438e-05	0	0	0	0	0.0001	0	0	rs370244576	19.20	D	D	D	D	D	D	H	D	D	0.639	D	D	D	0.626	.	0.793	0.363	T	D	D	D	D	D	3.412	24.400	0.999	D	D	0.412	4.421	0.243	3.403	1.000	0.517	0.547	0.479	0.563	.	4.570	4.570	2.177	0.646	0.599	0.993	0.002	0.004	958	Sialidase	.	.	ID=COSV57991730;OCCURENCE=1(large_intestine)	NEU4	160	0	364	36	0.09	TRUE	TRUE
ENSG00000144893.12	.	BCM	GRCh38.p13	chr3	151116342	151116342	+	A	A	G	Missense_Mutation	SNP	ENST00000474524.5	exon2	c.A104G	p.E35G	exonic	ENSG00000144893.12	.	nonsynonymous SNV	ENSG00000144893.12:ENST00000474524.5:exon2:c.A104G:p.E35G	3q25.1	C3N-01383	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	N	D	M	T	D	0.821	T	T	D	0.730	0.439	0.349	1.318	D	T	D	D	D	D	4.193	28.600	0.999	D	D	0.729	7.539	0.712	7.976	1.000	0.554	0.574	0.602	0.564	.	5.220	5.220	9.264	1.312	0.691	1.000	1.000	0.998	516	.	.	.	.	MED12L	63	0	118	18	0.132352941176471	TRUE	NA
ENSG00000181982.18	.	BCM	GRCh38.p13	chr4	24837253	24837253	+	C	C	T	Missense_Mutation	SNP	ENST00000635206.1	exon6	c.G637A	p.V213M	exonic	ENSG00000181982.18	.	nonsynonymous SNV	ENSG00000181982.18:ENST00000635206.1:exon6:c.G637A:p.V213M	4p15.2	C3N-01383	3.302e-05	0	0.0002	0	0	3.003e-05	0	0	rs200792138	8.15	D	D	.	.	D	D	.	.	N	0.671	T	T	T	0.261	.	0.210	1.501	T	.	T	D	D	D	3.651	25.200	0.999	D	N	0.679	6.839	0.694	7.645	0.999	0.651	0.547	0.653	0.684	.	6.070	6.070	3.026	1.026	0.599	1.000	0.983	0.896	843	.	.	.	.	CCDC149	127	0	233	26	0.1003861003861	TRUE	NA
ENSG00000185873.8	.	BCM	GRCh38.p13	chr4	68236009	68236009	+	T	T	A	Nonsense_Mutation	SNP	ENST00000332644.6	exon4	c.A301T	p.K101X	exonic	ENSG00000185873.8	.	stopgain	ENSG00000185873.8:ENST00000332644.6:exon4:c.A301T:p.K101X	4q13.2	C3N-01383	8.603e-06	0.0001	0	0	0	0	0	0	rs559293322	3.6	.	.	.	.	N	A	.	.	.	0.210	.	.	.	.	.	.	.	.	.	D	D	.	.	5.393	34	0.994	N	N	0.166	3.156	-0.113	2.011	0.000	0.487	0.574	0.574	0.564	.	4.980	2.240	0.295	0.125	0.589	0.252	0.817	0.976	779	SEA_domain	.	.	.	TMPRSS11B	85	0	84	14	0.142857142857143	TRUE	NA
ENSG00000052795.13	.	BCM	GRCh38.p13	chr4	158870318	158870318	+	A	A	T	Missense_Mutation	SNP	ENST00000264433.11	exon14	c.A2798T	p.Q933L	exonic	ENSG00000052795.13	.	nonsynonymous SNV	ENSG00000052795.13:ENST00000264433.11:exon14:c.A2798T:p.Q933L	4q32.1	C3N-01383	.	.	.	.	.	.	.	.	rs1024480054	6.20	D	D	B	B	N	N	L	T	D	0.381	T	T	T	0.087	0.252	0.043	0.146	T	T	T	T	D	T	3.124	23.700	0.991	D	D	0.238	3.477	0.351	4.027	1.000	0.563	0.588	0.784	0.636	.	5.740	5.740	3.950	1.312	0.756	1.000	1.000	0.999	867	Folliculin-interacting_protein,_C-terminal_domain;Tripartite_DENN_domain,_FNIP1/2-type	.	.	.	FNIP2	99	0	173	19	0.0989583333333333	TRUE	NA
ENSG00000164117.14	.	BCM	GRCh38.p13	chr4	174262962	174262962	+	-	NA	GAT	In_Frame_Ins	INS	ENST00000393674.7	exon2	c.130_131insATC	p.H43_R44insH	exonic	ENSG00000164117.14	.	nonframeshift insertion	ENSG00000164117.14:ENST00000393674.7:exon2:c.130_131insATC:p.H43_R44insH	4q34.1	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBXO8	NA	NA	NA	NA	NA	NA	NA
ENSG00000001084.13	.	BCM	GRCh38.p13	chr6	53514486	53514486	+	C	C	T	Missense_Mutation	SNP	ENST00000650454.1	exon5	c.G572A	p.R191K	exonic	ENSG00000001084.13	.	nonsynonymous SNV	ENSG00000001084.13:ENST00000650454.1:exon5:c.G572A:p.R191K	6p12.1	C3N-01383	.	.	.	.	.	.	.	.	.	9.20	T	T	P	B	D	D	L	T	N	0.742	T	T	D	0.217	0.413	0.692	0.681	D	T	D	T	D	D	3.009	23.400	0.900	D	D	0.425	4.505	0.531	5.451	1.000	0.707	0.709	0.725	0.714	.	5.940	5.940	7.472	1.026	0.599	1.000	1.000	0.997	697	.	.	.	.	GCLC	360	0	585	56	0.0873634945397816	TRUE	TRUE
ENSG00000106546.14	.	BCM	GRCh38.p13	chr7	17335701	17335703	+	CGA	CGA	-	In_Frame_Del	DEL	ENST00000242057.9	exon9	c.1075_1077del	p.R359del	exonic	ENSG00000106546.14;ENSG00000283321.1	.	nonframeshift deletion	ENSG00000106546.14:ENST00000242057.9:exon9:c.1075_1077del:p.R359del,ENSG00000283321.1:ENST00000637807.1:exon9:c.1045_1047del:p.R349del	7p21.1	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AHR	240	0	361	23	0.0598958333333333	NA	TRUE
ENSG00000158623.14	.	BCM	GRCh38.p13	chr7	130611076	130611076	+	T	T	C	Missense_Mutation	SNP	ENST00000425248.5	exon9	c.A614G	p.K205R	exonic	ENSG00000158623.14	.	nonsynonymous SNV	ENSG00000158623.14:ENST00000425248.5:exon9:c.A614G:p.K205R	7q32.2	C3N-01383	.	.	.	.	.	.	.	.	.	4.19	T	T	B	B	N	D	.	T	N	0.298	T	T	T	0.041	0.426	0.483	.	T	T	T	T	D	D	2.198	20.800	0.992	D	N	-0.270	1.689	-0.125	1.978	0.988	0.732	0.725	0.725	0.728	.	5.310	2.950	4.093	1.138	0.665	1.000	1.000	1.000	923	Clathrin/coatomer_adaptor,_adaptin-like,_N-terminal	.	.	.	COPG2	143	0	214	22	0.0932203389830508	TRUE	TRUE
ENSG00000131558.15	.	BCM	GRCh38.p13	chr7	133917635	133917637	+	GAT	GAT	-	In_Frame_Del	DEL	ENST00000253861.5	exon13	c.1924_1926del	p.D644del	exonic	ENSG00000131558.15	.	nonframeshift deletion	ENSG00000131558.15:ENST00000253861.5:exon13:c.1924_1926del:p.D644del	7q33	C3N-01383	8.237e-06	0	8.637e-05	0	0	0	0	0	rs751783828	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EXOC4	190	0	320	25	0.072463768115942	TRUE	NA
ENSG00000136574.17	.	BCM	GRCh38.p13	chr8	11708870	11708870	+	C	C	-	Frame_Shift_Del	DEL	ENST00000335135.8	exon2	c.558delC	p.P187Rfs*61	exonic	ENSG00000136574.17	.	frameshift deletion	ENSG00000136574.17:ENST00000335135.8:exon2:c.558delC:p.P187Rfs*61	8p23.1	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GATA4	95	0	442	43	0.088659793814433	TRUE	TRUE
ENSG00000205268.11	.	BCM	GRCh38.p13	chr8	65739588	65739588	+	A	A	G	Missense_Mutation	SNP	ENST00000401827.8	exon6	c.T509C	p.L170P	exonic	ENSG00000205268.11	.	nonsynonymous SNV	ENSG00000205268.11:ENST00000401827.8:exon6:c.T509C:p.L170P	8q13.1	C3N-01383	8.896e-06	0	0	0	0	1.597e-05	0	0	rs773177540	19.20	D	D	D	D	D	D	M	D	D	0.971	D	D	D	0.938	0.870	0.965	1.619	T	D	D	D	D	D	4.277	29.400	0.999	D	D	0.815	9.083	0.791	9.872	1.000	0.707	0.725	0.651	0.684	.	5.580	5.580	9.107	1.312	0.756	1.000	1.000	1.000	770	3'5'-cyclic_nucleotide_phosphodiesterase,_catalytic_domain	.	.	.	PDE7A	79	0	69	4	0.0547945205479452	TRUE	NA
ENSG00000164919.11	.	BCM	GRCh38.p13	chr8	99887587	99887587	+	T	T	C	Missense_Mutation	SNP	ENST00000520468.7	exon3	c.A146G	p.Y49C	exonic	ENSG00000164919.11	.	nonsynonymous SNV	ENSG00000164919.11:ENST00000520468.7:exon3:c.A146G:p.Y49C	8q22.2	C3N-01383	.	.	.	.	.	.	.	.	.	15.18	D	D	D	D	D	D	.	.	D	0.895	T	T	D	0.624	0.930	0.307	0.521	T	D	D	D	D	D	3.977	26.800	0.997	D	D	0.495	4.999	0.456	4.783	1.000	0.732	0.744	0.744	0.728	.	5.570	5.570	5.743	1.138	0.665	1.000	0.977	0.964	458	Mitochondrial_cytochrome_c_oxidase_subunit_VIc/VIIs	.	.	.	COX6C	140	0	221	21	0.0867768595041322	TRUE	TRUE
ENSG00000169436.17	.	BCM	GRCh38.p13	chr8	138878029	138878029	+	G	G	A	Missense_Mutation	SNP	ENST00000303045.11	exon3	c.C379T	p.R127C	exonic	ENSG00000169436.17	.	nonsynonymous SNV	ENSG00000169436.17:ENST00000303045.11:exon3:c.C379T:p.R127C	8q24.23	C3N-01383	2.273e-05	0	0	0.0003	0	0	0	0	rs758355984	2.20	T	T	P	P	U	N	L	D	N	0.380	T	T	D	0.285	0.643	0.440	0.116	T	T	T	T	T	T	2.850	23.100	0.997	N	N	0.010	2.545	-0.081	2.102	0.018	0.615	0.574	0.659	0.563	.	5.200	2.190	2.302	1.172	0.676	0.985	0.418	0.433	972	von_Willebrand_factor,_type_A	.	.	.	COL22A1	205	0	497	60	0.107719928186715	TRUE	NA
ENSG00000171855.7	.	BCM	GRCh38.p13	chr9	21077659	21077659	+	A	A	C	Missense_Mutation	SNP	ENST00000380232.4	exon1	c.T211G	p.F71V	exonic	ENSG00000171855.7	.	nonsynonymous SNV	ENSG00000171855.7:ENST00000380232.4:exon1:c.T211G:p.F71V	9p21.3	C3N-01383	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	D	0.139	T	T	T	0.026	0.507	0.359	0.015	T	T	T	T	D	T	-0.307	0.301	0.538	N	N	-1.458	0.095	-1.603	0.074	1.000	0.447	0.547	0.547	0.530	.	5.640	-7.850	-0.916	-0.736	-0.751	0.000	0.007	0.012	737	.	.	.	.	IFNB1	200	0	390	37	0.0866510538641686	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971187	21971187	+	G	G	A	Nonsense_Mutation	SNP	ENST00000304494.9	exon2	c.C172T	p.R58X	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon2:c.C172T:p.R58X	9p21.3	C3N-01383	.	.	.	.	.	.	.	.	rs121913387	4.15	D	T	.	.	N	D	.	T	D	0.185	T	T	.	0.220	.	0.879	.	.	T	T	T	D	T	5.550	34	0.997	N	N	-0.315	1.578	-0.449	1.286	1.000	0.677	0.383	0.608	0.601	.	5.790	2.710	-0.135	1.176	0.676	0.000	0.031	0.057	900	.	.	.	ID=COSV58682666;OCCURENCE=1(salivary_gland),3(breast),9(penis),1(peritoneum),5(liver),18(oesophagus),1(cervix),8(vulva),6(ovary),17(NS),4(haematopoietic_and_lymphoid_tissue),4(stomach),4(urinary_tract),2(soft_tissue),18(pancreas),41(skin),18(lung),42(upper_aerodigestive_tract),1(thymus),1(endometrium)	CDKN2A	308	0	771	83	0.0971896955503513	NA	TRUE
ENSG00000148482.12	.	BCM	GRCh38.p13	chr10	17965681	17965681	+	C	C	T	Missense_Mutation	SNP	ENST00000377369.7	exon4	c.C742T	p.R248C	exonic	ENSG00000148482.12	.	nonsynonymous SNV	ENSG00000148482.12:ENST00000377369.7:exon4:c.C742T:p.R248C	10p12.33	C3N-01383	0.0001	0	9.151e-05	0.0001	0	3.138e-05	0	0.0007	rs187451149	5.20	D	D	P	P	N	D	N	T	N	0.223	T	T	T	0.074	.	0.423	0.063	T	T	T	T	T	D	2.655	22.700	0.999	D	N	0.285	3.703	0.361	4.095	0.139	0.554	0.588	0.574	0.564	.	5.810	5.810	2.108	1.026	0.599	0.936	0.032	0.534	940	.	.	.	.	SLC39A12	152	1	250	32	0.113475177304965	TRUE	NA
ENSG00000138347.15	.	BCM	GRCh38.p13	chr10	68197399	68197399	+	G	G	A	Missense_Mutation	SNP	ENST00000358913.9	exon16	c.G3206A	p.R1069H	exonic	ENSG00000138347.15	.	nonsynonymous SNV	ENSG00000138347.15:ENST00000358913.9:exon16:c.G3206A:p.R1069H	10q21.3	C3N-01383	1.648e-05	0	0	0	0	0	0	0.0001	rs763362861	13.20	D	D	D	D	N	D	M	T	D	0.796	T	T	D	0.348	0.356	0.803	0.581	T	T	T	D	D	D	4.552	32	1.000	D	D	0.713	7.301	0.700	7.751	0.693	0.526	0.574	0.616	0.530	.	5.160	5.160	7.758	1.155	0.676	1.000	1.000	0.998	929	.	.	.	.	MYPN	442	1	856	96	0.100840336134454	TRUE	NA
ENSG00000186113.1	.	BCM	GRCh38.p13	chr11	55796288	55796288	+	T	T	A	Missense_Mutation	SNP	ENST00000335605.1	exon1	c.T733A	p.S245T	exonic	ENSG00000186113.1	.	nonsynonymous SNV	ENSG00000186113.1:ENST00000335605.1:exon1:c.T733A:p.S245T	11q11	C3N-01383	.	.	.	.	.	.	.	.	.	9.20	D	D	D	D	D	N	M	T	D	0.169	T	T	T	0.172	0.450	0.632	0.092	T	T	T	T	D	T	3.112	23.700	0.988	D	N	0.293	3.741	0.129	2.858	0.000	0.487	0.574	0.574	0.564	.	5.080	3.930	1.006	-0.036	-0.210	0.534	0.904	0.282	155	GPCR,_rhodopsin-like,_7TM	.	.	.	OR5D14	171	0	277	32	0.103559870550162	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-01383	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	343	0	508	52	0.0928571428571429	TRUE	TRUE
ENSG00000133704.10	.	BCM	GRCh38.p13	chr12	30639596	30639596	+	C	C	T	Missense_Mutation	SNP	ENST00000256079.9	exon21	c.G2408A	p.R803Q	exonic	ENSG00000133704.10	.	nonsynonymous SNV	ENSG00000133704.10:ENST00000256079.9:exon21:c.G2408A:p.R803Q	12p11.21	C3N-01383	1.648e-05	9.61e-05	0	0	0	1.498e-05	0	0	rs778254539	0.20	T	T	B	B	N	N	N	T	N	0.136	T	T	T	0.073	0.464	0.241	0.305	T	T	T	T	T	T	1.681	16.900	0.961	N	N	-0.887	0.537	-0.774	0.795	0.000	0.707	0.725	0.644	0.714	.	5.040	-1.270	0.600	-0.216	0.599	0.985	0.702	0.998	964	.	.	.	ID=COSV56240309;OCCURENCE=1(large_intestine),1(endometrium)	IPO8	266	0	511	50	0.089126559714795	TRUE	TRUE
ENSG00000167767.14	.	BCM	GRCh38.p13	chr12	52191639	52191639	+	C	C	G	Missense_Mutation	SNP	ENST00000394815.3	exon1	c.G264C	p.K88N	exonic	ENSG00000167767.14	.	nonsynonymous SNV	ENSG00000167767.14:ENST00000394815.3:exon1:c.G264C:p.K88N	12q13.13	C3N-01383	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	.	D	M	D	D	0.745	D	D	D	0.592	0.659	0.697	0.583	T	D	D	D	D	T	3.207	23.900	0.997	D	N	0.406	4.378	0.249	3.434	1.000	0.387	0.590	0.578	0.722	.	5.250	2.440	1.504	-0.231	-0.773	0.793	0.983	0.981	334	Intermediate_filament,_rod_domain	.	.	.	KRT80	78	0	132	17	0.114093959731544	TRUE	TRUE
ENSG00000167768.4	.	BCM	GRCh38.p13	chr12	52677416	52677416	+	C	C	T	Missense_Mutation	SNP	ENST00000252244.3	exon5	c.G1028A	p.R343H	exonic	ENSG00000167768.4	.	nonsynonymous SNV	ENSG00000167768.4:ENST00000252244.3:exon5:c.G1028A:p.R343H	12q13.13	C3N-01383	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	.	D	M	T	D	0.661	D	D	D	0.789	0.783	0.879	1.051	T	D	D	D	D	D	4.032	27.200	0.999	D	D	0.858	10.030	0.789	9.812	1.000	0.497	0.590	0.547	0.530	.	5.220	5.220	7.813	0.947	0.549	1.000	0.968	0.835	716	Intermediate_filament,_rod_domain	.	.	ID=COSV52866558;OCCURENCE=1(large_intestine),1(kidney),1(endometrium)	KRT1	280	0	586	38	0.0608974358974359	TRUE	TRUE
ENSG00000133958.13	.	BCM	GRCh38.p13	chr14	93577947	93577947	+	C	C	T	Missense_Mutation	SNP	ENST00000393151.6	exon18	c.C2317T	p.R773C	exonic	ENSG00000133958.13	.	nonsynonymous SNV	ENSG00000133958.13:ENST00000393151.6:exon18:c.C2317T:p.R773C	14q32.12	C3N-01383	1.647e-05	0	0	0.0001	0	1.498e-05	0	0	rs781756182	7.17	D	D	.	.	D	D	L	T	N	0.193	T	T	T	0.120	0.144	0.043	0.974	T	T	T	T	D	.	3.301	24.100	0.999	D	D	0.547	5.427	0.595	6.164	0.361	0.554	0.574	0.602	0.564	.	5.330	5.330	5.371	1.026	0.599	1.000	0.998	0.977	819	.	.	.	ID=COSV56376369;OCCURENCE=5(skin)	UNC79	355	0	651	51	0.0726495726495727	TRUE	TRUE
ENSG00000137872.17	.	BCM	GRCh38.p13	chr15	47765933	47765933	+	G	G	A	Missense_Mutation	SNP	ENST00000536845.7	exon14	c.G1492A	p.A498T	exonic	ENSG00000137872.17	.	nonsynonymous SNV	ENSG00000137872.17:ENST00000536845.7:exon14:c.G1492A:p.A498T	15q21.1	C3N-01383	2.689e-05	0	8.708e-05	0	0	0	0	0.0002	rs562979514	3.20	T	T	P	B	N	D	L	T	N	0.149	T	T	T	0.049	0.390	0.043	0.075	T	T	T	T	T	D	1.896	18.460	0.947	D	N	-0.300	1.613	-0.244	1.683	1.000	0.651	0.574	0.651	0.636	.	5.680	3.820	3.393	0.116	-0.127	1.000	0.966	0.972	755	Sema_domain	.	.	.	SEMA6D	32	0	57	7	0.109375	TRUE	NA
ENSG00000075131.10	.	BCM	GRCh38.p13	chr15	66352863	66352863	+	G	G	A	Missense_Mutation	SNP	ENST00000261881.9	exon2	c.C85T	p.P29S	exonic	ENSG00000075131.10	.	nonsynonymous SNV	ENSG00000075131.10:ENST00000261881.9:exon2:c.C85T:p.P29S	15q22.31	C3N-01383	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	D	0.436	T	T	T	0.269	0.269	0.661	0.495	T	T	T	T	D	T	3.793	25.800	0.999	D	D	0.720	7.415	0.684	7.466	1.000	0.732	0.725	0.744	0.728	.	4.720	4.720	8.008	1.143	0.656	1.000	1.000	0.991	754	.	.	.	.	TIPIN	108	0	197	12	0.0574162679425837	NA	TRUE
ENSG00000120071.14	.	BCM	GRCh38.p13	chr17	46171240	46171240	+	G	G	A	Nonsense_Mutation	SNP	ENST00000432791.6	exon2	c.C904T	p.Q302X	exonic	ENSG00000120071.14	.	stopgain	ENSG00000120071.14:ENST00000432791.6:exon2:c.C904T:p.Q302X	17q21.31	C3N-01383	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.381	.	.	.	.	.	.	.	.	.	D	D	.	.	7.051	37	0.998	D	N	1.213	24.933	1.100	27.073	1.000	0.707	0.702	0.696	0.714	.	6.040	6.040	7.430	1.172	0.676	1.000	1.000	0.997	169	.	.	.	.	KANSL1	244	0	414	40	0.0881057268722467	TRUE	TRUE
ENSG00000266074.8	.	BCM	GRCh38.p13	chr17	81447351	81447351	+	C	C	T	Missense_Mutation	SNP	ENST00000584436.7	exon12	c.C3572T	p.A1191V	exonic	ENSG00000266074.8	.	nonsynonymous SNV	ENSG00000266074.8:ENST00000584436.7:exon12:c.C3572T:p.A1191V	17q25.3	C3N-01383	0.0002	0	0.0005	0.0004	0	5.654e-05	0	0.0003	rs549555237	1.19	D	T	B	B	N	N	.	T	N	0.167	T	T	T	0.032	.	0.014	0.084	T	T	T	T	T	T	0.805	9.439	0.993	N	N	-1.196	0.230	-1.136	0.340	0.017	0.581	0.547	0.578	0.605	.	4.340	3.370	1.037	-0.125	-0.688	0.006	0.005	0.048	.	.	.	.	ID=COSV57023720;OCCURENCE=1(stomach)	BAHCC1	79	1	110	17	0.133858267716535	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51048836	51048836	+	G	G	T	Nonsense_Mutation	SNP	ENST00000342988.8	exon3	c.G400T	p.E134X	exonic	ENSG00000141646.14	.	stopgain	ENSG00000141646.14:ENST00000342988.8:exon3:c.G400T:p.E134X	18q21.2	C3N-01383	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.971	.	.	.	.	.	.	.	.	.	D	D	.	.	7.290	37	0.998	D	N	1.080	16.696	0.953	16.240	1.000	0.732	0.725	0.663	0.728	.	5.480	5.480	8.153	1.176	0.618	1.000	1.000	0.998	681	MAD_homology_1,_Dwarfin-type;MAD_homology,_MH1	.	.	.	SMAD4	249	0	371	60	0.139211136890951	TRUE	TRUE
ENSG00000065000.19	.	BCM	GRCh38.p13	chr19	2111804	2111804	+	T	T	G	Missense_Mutation	SNP	ENST00000345016.9	exon23	c.A2626C	p.K876Q	exonic	ENSG00000065000.19	.	nonsynonymous SNV	ENSG00000065000.19:ENST00000345016.9:exon23:c.A2626C:p.K876Q	19p13.3	C3N-01383	0.0007	0.0006	0.0004	0	0	0.0003	0.0012	0.0027	rs201127154	6.20	T	T	D	D	N	D	M	T	N	0.295	T	T	D	0.172	.	0.713	0.093	T	T	T	T	T	T	2.323	21.700	0.911	D	N	-0.150	2.022	-0.202	1.780	0.872	0.707	0.702	0.702	0.714	.	4.340	3.330	1.853	0.138	-0.178	1.000	0.994	0.572	952	.	.	.	.	AP3D1	207	0	486	54	0.1	TRUE	NA
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8136424	8136424	+	C	C	T	Missense_Mutation	SNP	ENST00000600128.6	exon11	c.G1309A	p.V437M	exonic	ENSG00000142449.13	.	nonsynonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon11:c.G1309A:p.V437M	19p13.2	C3N-01383	8.253e-06	0	0	0.0001	0	0	0	0	rs765550768	2.20	T	T	B	B	U	N	N	D	N	0.149	T	T	D	0.189	0.498	0.551	0.207	T	T	T	T	T	T	-1.303	0.001	0.951	N	N	-1.179	0.242	-1.269	0.230	0.293	0.672	0.547	0.702	0.613	.	4.400	-5.230	-0.107	-0.431	-0.916	0.012	0.000	0.000	934	EGF-like,_conserved_site;EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	FBN3	163	1	363	38	0.0947630922693267	TRUE	NA
ENSG00000131351.15	.	BCM	GRCh38.p13	chr19	17050054	17050054	+	T	T	C	Missense_Mutation	SNP	ENST00000253669.10	exon11	c.A1052G	p.D351G	exonic	ENSG00000131351.15	.	nonsynonymous SNV	ENSG00000131351.15:ENST00000253669.10:exon11:c.A1052G:p.D351G	19p13.11	C3N-01383	.	.	.	.	.	.	.	.	.	2.20	D	D	B	B	N	N	L	T	N	0.206	T	T	T	0.068	0.189	0.246	0.169	T	T	T	T	T	T	1.171	13.400	0.967	N	N	-0.882	0.543	-0.932	0.577	1.000	0.732	0.725	0.723	0.728	.	3.770	2.100	0.812	0.776	0.665	0.010	0.026	0.002	970	.	.	.	.	HAUS8	82	0	147	16	0.098159509202454	TRUE	TRUE
ENSG00000130844.18	.	BCM	GRCh38.p13	chr19	53577855	53577855	+	C	C	T	Missense_Mutation	SNP	ENST00000253144.13	exon7	c.C1295T	p.T432M	exonic	ENSG00000130844.18	.	nonsynonymous SNV	ENSG00000130844.18:ENST00000253144.13:exon7:c.C1295T:p.T432M	19q13.42	C3N-01383	.	.	.	.	.	.	.	.	.	2.19	D	D	B	B	N	N	L	T	N	0.112	T	T	T	0.084	0.506	0.147	0.778	T	T	T	T	T	T	1.367	14.860	0.976	N	.	-0.684	0.840	-0.822	0.727	0.073	0.707	0.725	0.725	0.636	.	3.580	-0.234	-2.059	-0.079	0.581	0.000	0.241	0.420	994	Zinc_finger_C2H2-type	.	.	.	ZNF331	200	1	320	28	0.0804597701149425	TRUE	NA
ENSG00000132635.17	.	BCM	GRCh38.p13	chr20	2838997	2838997	+	C	C	T	Missense_Mutation	SNP	ENST00000360652.7	exon4	c.G290A	p.R97H	exonic	ENSG00000132635.17	.	nonsynonymous SNV	ENSG00000132635.17:ENST00000360652.7:exon4:c.G290A:p.R97H	20p13	C3N-01383	8.268e-06	0	8.651e-05	0	0	0	0	0	rs753469763	15.20	D	D	D	D	D	D	M	T	D	0.934	T	T	D	0.504	.	0.560	1.382	T	T	D	D	D	D	3.898	26.300	0.999	D	D	0.680	6.854	0.579	5.975	1.000	0.660	0.663	0.383	0.684	.	3.760	3.760	4.909	1.016	0.587	1.000	1.000	0.997	466	.	.	.	.	PCED1A	340	2	663	62	0.0855172413793103	TRUE	NA
ENSG00000125885.13	.	BCM	GRCh38.p13	chr20	5977987	5977987	+	G	G	A	Missense_Mutation	SNP	ENST00000610722.4	exon13	c.G1507A	p.E503K	exonic	ENSG00000125885.13;ENSG00000286235.1	.	nonsynonymous SNV	ENSG00000125885.13:ENST00000610722.4:exon13:c.G1507A:p.E503K,ENSG00000286235.1:ENST00000652720.1:exon13:c.G1507A:p.E503K	20p12.3	C3N-01383	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.973	T	T	D	0.656	0.814	0.629	0.642	D	T	D	D	D	D	4.560	32	0.999	D	D	1.025	14.716	0.979	17.595	1.000	0.732	0.725	0.744	0.728	.	5.730	5.730	9.487	1.176	0.676	1.000	1.000	1.000	665	AAA+_ATPase_domain;MCM_domain	.	.	.	MCM8	149	0	261	24	0.0842105263157895	TRUE	TRUE
ENSG00000132671.5	.	BCM	GRCh38.p13	chr20	23036609	23036609	+	G	G	A	Missense_Mutation	SNP	ENST00000255008.4	exon1	c.G1126A	p.G376S	exonic	ENSG00000132671.5	.	nonsynonymous SNV	ENSG00000132671.5:ENST00000255008.4:exon1:c.G1126A:p.G376S	20p11.21	C3N-01383	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.012	T	T	D	0.034	0.209	0.206	0.426	T	T	T	T	T	T	0.088	1.988	0.462	N	N	-1.638	0.047	-1.680	0.055	0.997	0.497	0.590	0.563	0.530	.	3.920	-3.450	-0.189	-2.192	-0.563	0.000	0.000	0.005	862	.	.	.	.	SSTR4	32	0	75	5	0.0625	TRUE	NA
ENSG00000087460.25	.	BCM	GRCh38.p13	chr20	58909366	58909366	+	G	G	A	Missense_Mutation	SNP	ENST00000371100.8	exon8	c.G2531A	p.R844H	exonic	ENSG00000087460.25	.	nonsynonymous SNV	ENSG00000087460.25:ENST00000371100.8:exon8:c.G2531A:p.R844H	20q13.32	C3N-01383	7.414e-05	9.61e-05	8.64e-05	0.0002	0	5.994e-05	0	6.057e-05	rs121913495	20.20	D	D	D	D	D	D	H	D	D	0.941	D	D	D	0.969	0.901	1.000	3.504	D	D	D	D	D	D	4.798	33	0.999	D	D	1.106	17.755	1.000	18.858	1.000	0.722	0.699	0.702	0.735	.	5.530	5.530	9.471	1.176	0.676	1.000	0.761	0.911	987	.	.	.	ID=COSV55670349;OCCURENCE=2(breast),7(liver),17(peritoneum),1(oesophagus),11(adrenal_gland),8(cervix),152(large_intestine),24(biliary_tract),7(ovary),122(bone),8(NS),11(haematopoietic_and_lymphoid_tissue),19(stomach),1(urinary_tract),2(kidney),30(soft_tissue),206(pancreas),17(pituitary),1(skin),7(lung),18(thyroid),35(small_intestine)	GNAS	567	2	1199	111	0.0847328244274809	NA	TRUE
ENSG00000154736.6	.	BCM	GRCh38.p13	chr21	26934548	26934548	+	G	G	A	Missense_Mutation	SNP	ENST00000284987.6	exon4	c.C1607T	p.A536V	exonic	ENSG00000154736.6	.	nonsynonymous SNV	ENSG00000154736.6:ENST00000284987.6:exon4:c.C1607T:p.A536V	21q21.3	C3N-01383	3.295e-05	0	0	0	0	5.994e-05	0	0	rs752801493	10.20	D	T	D	P	D	D	M	T	N	0.788	T	T	D	0.285	0.549	0.858	1.292	T	T	T	T	D	D	3.736	25.600	0.999	D	D	0.352	4.057	0.251	3.445	1.000	0.554	0.574	0.602	0.564	.	5.680	4.790	7.593	1.176	0.676	1.000	0.373	0.761	735	ADAM,_cysteine-rich	.	.	ID=COSV53183225;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	ADAMTS5	351	1	708	54	0.0708661417322835	TRUE	TRUE
ENSG00000185448.10	.	BCM	GRCh38.p13	chrX	34131494	34131494	+	C	C	T	Missense_Mutation	SNP	ENST00000346193.4	exon1	c.G785A	p.R262Q	exonic	ENSG00000185448.10	.	nonsynonymous SNV	ENSG00000185448.10:ENST00000346193.4:exon1:c.G785A:p.R262Q	Xp21.1	C3N-01383	.	.	.	.	.	.	.	.	.	0.18	T	T	P	B	.	N	L	T	N	0.092	T	T	T	0.051	0.247	0.043	0.428	T	T	T	T	T	T	0.151	2.590	0.698	N	.	.	.	.	.	0.000	.	.	.	.	.	0.130	0.130	-1.581	-1.837	-1.708	0.000	0.001	0.001	937	.	.	.	ID=COSV60497337;OCCURENCE=1(skin)	FAM47A	261	1	431	53	0.109504132231405	TRUE	TRUE
ENSG00000176406.23	.	BCM	GRCh38.p13	chr8	104068511	104068511	+	G	G	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000176406.23	ENST00000666250.1:exon24:c.3548-1G>T	.	.	8q22.3	C3N-01383	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	3.466	24.600	0.995	D	.	0.432	4.550	0.514	5.291	0.960	0.054	0.063	0.060	0.057	0.970	5.300	5.300	7.272	1.176	0.676	1.000	1.000	0.999	758	.	.	.	ID=COSV99165552;OCCURENCE=1(skin)	RIMS2	124	0	193	38	0.164502164502165	TRUE	NA
ENSG00000108582.12	.	BCM	GRCh38.p13	chr17	30420985	30420985	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000108582.12	ENST00000225719.9:exon3:c.1137+2T>C	.	.	17q11.2	C3N-01383	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.320	33	0.993	D	.	1.177	21.835	1.043	21.737	1.000	0.164	0.097	0.060	0.243	0.973	5.810	5.810	7.825	1.138	0.665	1.000	1.000	0.999	598	.	.	.	.	CPD	101	0	178	20	0.101010101010101	TRUE	TRUE
ENSG00000158816.15	.	BCM	GRCh38.p13	chr1	20345481	20345481	+	C	C	T	Silent	SNP	ENST00000375079.6	exon17	c.C2652T	p.S884S	exonic	ENSG00000158816.15	.	synonymous SNV	ENSG00000158816.15:ENST00000375079.6:exon17:c.C2652T:p.S884S	1p36.12	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VWA5B1	270	0	517	52	0.0913884007029877	TRUE	NA
ENSG00000143520.6	.	BCM	GRCh38.p13	chr1	152358792	152358792	+	A	A	G	Silent	SNP	ENST00000388718.5	exon2	c.T93C	p.G31G	exonic	ENSG00000143520.6	.	synonymous SNV	ENSG00000143520.6:ENST00000388718.5:exon2:c.T93C:p.G31G	1q21.3	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FLG2	193	0	335	28	0.0771349862258953	TRUE	TRUE
ENSG00000163462.18	.	BCM	GRCh38.p13	chr1	155182090	155182090	+	C	C	T	Silent	SNP	ENST00000334634.9	exon9	c.C1827T	p.V609V	exonic	ENSG00000163462.18	.	synonymous SNV	ENSG00000163462.18:ENST00000334634.9:exon9:c.C1827T:p.V609V	1q22	C3N-01383	0.0001	0	0	0	0	0.0002	0	0	rs200101530	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIM46	245	0	573	60	0.0947867298578199	TRUE	NA
ENSG00000143341.12	.	BCM	GRCh38.p13	chr1	186001710	186001710	+	T	T	A	Silent	SNP	ENST00000271588.9	exon28	c.T4317A	p.T1439T	exonic	ENSG00000143341.12	.	synonymous SNV	ENSG00000143341.12:ENST00000271588.9:exon28:c.T4317A:p.T1439T	1q31.1	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HMCN1	267	0	429	43	0.0911016949152542	TRUE	TRUE
ENSG00000066032.18	.	BCM	GRCh38.p13	chr2	80581813	80581813	+	C	C	T	Silent	SNP	ENST00000402739.8	exon13	c.C2001T	p.S667S	exonic	ENSG00000066032.18	.	synonymous SNV	ENSG00000066032.18:ENST00000402739.8:exon13:c.C2001T:p.S667S	2p12	C3N-01383	2.503e-05	0	8.834e-05	0.0001	0	1.507e-05	0	0	rs368214934	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTNNA2	153	0	252	24	0.0869565217391304	TRUE	NA
ENSG00000113810.16	.	BCM	GRCh38.p13	chr3	160428922	160428922	+	A	A	G	Silent	SNP	ENST00000357388.8	exon18	c.A2775G	p.V925V	exonic	ENSG00000113810.16	.	synonymous SNV	ENSG00000113810.16:ENST00000357388.8:exon18:c.A2775G:p.V925V	3q25.33	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMC4	117	0	135	12	0.0816326530612245	TRUE	NA
ENSG00000049167.14	.	BCM	GRCh38.p13	chr5	60928908	60928908	+	G	G	A	Silent	SNP	ENST00000265038.9	exon2	c.C129T	p.G43G	exonic	ENSG00000049167.14	.	synonymous SNV	ENSG00000049167.14:ENST00000265038.9:exon2:c.C129T:p.G43G	5q12.1	C3N-01383	7.425e-05	0	0.0007	0	0	1.5e-05	0	0	rs145518936	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54014655;OCCURENCE=1(large_intestine)	ERCC8	212	0	302	28	0.0848484848484849	TRUE	TRUE
ENSG00000129103.18	.	BCM	GRCh38.p13	chr7	56074606	56074606	+	C	C	T	Silent	SNP	ENST00000434526.7	exon5	c.C405T	p.G135G	exonic	ENSG00000129103.18	.	synonymous SNV	ENSG00000129103.18:ENST00000434526.7:exon5:c.C405T:p.G135G	7p11.2	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUMF2	93	0	204	18	0.0810810810810811	TRUE	TRUE
ENSG00000137571.11	.	BCM	GRCh38.p13	chr8	69673226	69673226	+	G	G	A	Silent	SNP	ENST00000260126.9	exon10	c.C2190T	p.N730N	exonic	ENSG00000137571.11	.	synonymous SNV	ENSG00000137571.11:ENST00000260126.9:exon10:c.C2190T:p.N730N	8q13.3	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLCO5A1	279	0	652	56	0.0790960451977401	TRUE	TRUE
ENSG00000176566.5	.	BCM	GRCh38.p13	chr8	87873336	87873336	+	G	G	A	Silent	SNP	ENST00000319675.5	exon1	c.C636T	p.N212N	exonic	ENSG00000176566.5	.	synonymous SNV	ENSG00000176566.5:ENST00000319675.5:exon1:c.C636T:p.N212N	8q21.3	C3N-01383	2.471e-05	0	0	0	0	2.997e-05	0.0011	0	rs866117569	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DCAF4L2	310	1	606	122	0.167582417582418	TRUE	NA
ENSG00000174669.12	.	BCM	GRCh38.p13	chr11	66367843	66367843	+	G	G	A	Silent	SNP	ENST00000357440.7	exon6	c.C577T	p.L193L	exonic	ENSG00000174669.12	.	synonymous SNV	ENSG00000174669.12:ENST00000357440.7:exon6:c.C577T:p.L193L	11q13.2	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC29A2	347	0	662	67	0.0919067215363512	TRUE	TRUE
ENSG00000151067.22	.	BCM	GRCh38.p13	chr12	2504904	2504904	+	G	G	A	Silent	SNP	ENST00000399655.6	exon8	c.G1176A	p.G392G	exonic	ENSG00000151067.22	.	synonymous SNV	ENSG00000151067.22:ENST00000399655.6:exon8:c.G1176A:p.G392G	12p13.33	C3N-01383	.	.	.	.	.	.	.	.	rs1051360	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA1C	319	0	597	49	0.0758513931888545	TRUE	TRUE
ENSG00000136155.17	.	BCM	GRCh38.p13	chr13	77572142	77572142	+	G	G	A	Silent	SNP	ENST00000349847.4	exon9	c.G498A	p.P166P	exonic	ENSG00000136155.17	.	synonymous SNV	ENSG00000136155.17:ENST00000349847.4:exon9:c.G498A:p.P166P	13q22.3	C3N-01383	1.652e-05	0	8.675e-05	0	0	0	0	6.108e-05	rs528874271	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCEL	171	0	307	39	0.11271676300578	TRUE	NA
ENSG00000119720.18	.	BCM	GRCh38.p13	chr14	90304034	90304034	+	G	G	A	Silent	SNP	ENST00000354366.8	exon5	c.C906T	p.S302S	exonic	ENSG00000119720.18	.	synonymous SNV	ENSG00000119720.18:ENST00000354366.8:exon5:c.C906T:p.S302S	14q32.11	C3N-01383	1.648e-05	0	0	0	0	2.997e-05	0	0	rs375950270	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NRDE2	175	2	352	45	0.113350125944584	TRUE	NA
ENSG00000169594.13	.	BCM	GRCh38.p13	chr15	83257523	83257523	+	C	C	T	Silent	SNP	ENST00000345382.6	exon5	c.G2904A	p.S968S	exonic	ENSG00000169594.13	.	synonymous SNV	ENSG00000169594.13:ENST00000345382.6:exon5:c.G2904A:p.S968S	15q25.2	C3N-01383	.	.	.	.	.	.	.	.	rs1021377126	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61757413;OCCURENCE=1(breast)	BNC1	225	0	404	52	0.114035087719298	TRUE	TRUE
ENSG00000196218.13	.	BCM	GRCh38.p13	chr19	38564988	38564988	+	C	C	T	Silent	SNP	ENST00000359596.8	exon91	c.C12654T	p.F4218F	exonic	ENSG00000196218.13	.	synonymous SNV	ENSG00000196218.13:ENST00000359596.8:exon91:c.C12654T:p.F4218F	19q13.2	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62094637;OCCURENCE=2(cervix),1(lung)	RYR1	276	0	609	50	0.0758725341426404	TRUE	TRUE
ENSG00000203865.10	.	BCM	GRCh38.p13	chr1	116405836	116405836	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000203865.10	.	.	.	1p13.1	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP1A1-AS1	53	0	89	7	0.0729166666666667	TRUE	NA
ENSG00000163539.17	.	BCM	GRCh38.p13	chr3	33717810	33717810	+	G	G	C	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000163539.17;ENSG00000228112.1	dist=58369;dist=9440	.	.	3p22.3	C3N-01383	.	.	.	.	.	.	.	.	.	9.17	D	D	.	.	N	D	.	T	D	0.246	T	T	D	0.136	0.510	0.307	0.792	T	T	T	T	D	D	3.842	26.000	0.996	D	D	-0.139	2.055	-0.031	2.256	1.000	0.442	0.219	0.504	0.562	.	4.210	2.210	5.025	1.080	0.676	1.000	1.000	0.994	326	TOG_domain	.	.	.	CLASP2	248	0	586	51	0.0800627943485086	TRUE	TRUE
ENSG00000196083.10	.	BCM	GRCh38.p13	chr3	190615313	190615313	+	A	A	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000196083.10	.	.	.	3q28	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IL1RAP	130	0	205	17	0.0765765765765766	TRUE	TRUE
ENSG00000186439.14	.	BCM	GRCh38.p13	chr6	123503693	123503693	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000186439.14	.	.	.	6q22.31	C3N-01383	6.244e-05	0	0.0003	0	0	4.866e-05	0	6.478e-05	rs369589621	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRDN	230	1	363	34	0.0856423173803526	TRUE	NA
ENSG00000257962.1	.	BCM	GRCh38.p13	chr8	85246387	85246387	+	T	T	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000257962.1	.	.	.	8q21.2	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC011773.2	250	0	415	41	0.0899122807017544	TRUE	NA
ENSG00000254872.3	.	BCM	GRCh38.p13	chr11	1086737	1086737	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000254872.3;ENSG00000198788.8	dist=30988;dist=15718	.	.	11p15.5	C3N-01383	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC02688	58	0	95	6	0.0594059405940594	TRUE	NA
ENSG00000197182.14	.	BCM	GRCh38.p13	chr22	46112807	46112807	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000197182.14;ENSG00000283990.1	.	.	.	22q13.31	C3N-01383	.	.	.	.	.	.	.	.	rs970921980	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIRLET7BHG	102	0	298	25	0.0773993808049536	TRUE	NA
ENSG00000159363.18	.	BCM	GRCh38.p13	chr1	16991749	16991749	+	C	C	A	Missense_Mutation	SNP	ENST00000326735.13	exon20	c.G2236T	p.A746S	exonic	ENSG00000159363.18	.	nonsynonymous SNV	ENSG00000159363.18:ENST00000326735.13:exon20:c.G2236T:p.A746S	1p36.13	C3N-03439	.	.	.	.	.	.	.	.	.	3.20	T	D	B	B	D	N	N	T	N	0.285	T	T	D	0.075	0.492	0.458	0.311	T	T	T	T	T	T	1.078	12.540	0.973	N	N	-0.840	0.599	-0.669	0.944	0.758	0.706	0.710	0.723	0.714	.	4.930	3.810	0.112	-0.186	-0.341	0.300	0.895	0.064	846	.	.	.	.	ATP13A2	335	0	506	51	0.0915619389587074	TRUE	TRUE
ENSG00000121904.17	.	BCM	GRCh38.p13	chr1	33611190	33611190	+	C	C	T	Missense_Mutation	SNP	ENST00000373388.6	exon41	c.G6074A	p.R2025Q	exonic	ENSG00000121904.17	.	nonsynonymous SNV	ENSG00000121904.17:ENST00000373388.6:exon41:c.G6074A:p.R2025Q	1p35.1	C3N-03439	5.799e-05	0.0002	0	0	0	7.532e-05	0	0	rs372340478	6.20	T	T	D	D	D	D	L	T	N	0.503	T	T	T	0.220	.	0.441	.	T	T	T	T	T	T	2.488	22.400	0.998	D	D	0.263	3.596	0.297	3.697	1.000	0.706	0.590	0.710	0.564	.	5.370	4.460	2.685	0.126	0.599	0.986	0.995	0.977	468	CUB_domain	.	.	ID=COSV53892070;OCCURENCE=1(large_intestine)	CSMD2	496	0	702	59	0.0775295663600526	TRUE	TRUE
ENSG00000134215.16	.	BCM	GRCh38.p13	chr1	107596241	107596241	+	C	C	G	Missense_Mutation	SNP	ENST00000370056.9	exon25	c.G2321C	p.G774A	exonic	ENSG00000134215.16	.	nonsynonymous SNV	ENSG00000134215.16:ENST00000370056.9:exon25:c.G2321C:p.G774A	1p13.3	C3N-03439	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	L	T	N	0.093	T	T	T	0.051	0.148	0.656	0.215	T	T	T	T	T	T	1.330	14.600	0.215	D	N	-0.296	1.625	-0.160	1.884	0.607	0.638	0.588	0.653	0.621	.	5.310	4.360	1.304	1.026	0.599	0.981	0.985	0.959	750	.	.	.	.	VAV3	135	0	232	21	0.08300395256917	TRUE	TRUE
ENSG00000163564.15	.	BCM	GRCh38.p13	chr1	158939222	158939222	+	C	C	A	Missense_Mutation	SNP	ENST00000368140.6	exon4	c.C554A	p.A185D	exonic	ENSG00000163564.15	.	nonsynonymous SNV	ENSG00000163564.15:ENST00000368140.6:exon4:c.C554A:p.A185D	1q23.1	C3N-03439	.	.	.	.	.	.	.	.	.	4.19	D	D	D	P	.	N	L	T	D	0.228	T	T	T	0.078	0.077	0.361	0.204	T	T	T	T	T	T	1.543	16.010	0.978	N	N	-0.551	1.079	-0.798	0.761	0.000	0.638	0.670	0.574	0.621	.	2.310	1.390	0.225	-0.287	-0.276	0.000	0.000	0.001	923	.	.	.	.	PYHIN1	86	0	127	54	0.298342541436464	TRUE	TRUE
ENSG00000162745.10	.	BCM	GRCh38.p13	chr1	162006443	162006443	+	C	C	T	Missense_Mutation	SNP	ENST00000294794.7	exon4	c.G577A	p.E193K	exonic	ENSG00000162745.10	.	nonsynonymous SNV	ENSG00000162745.10:ENST00000294794.7:exon4:c.G577A:p.E193K	1q23.3	C3N-03439	3.31e-05	0	0	0	0	1.502e-05	0	0.0002	rs759621817	0.19	T	T	B	B	.	N	L	T	N	0.127	T	T	T	0.017	.	0.067	0.131	T	T	T	T	T	T	1.260	14.100	0.987	N	N	-0.999	0.405	-0.989	0.503	0.999	0.706	0.590	0.710	0.616	.	4.740	1.820	0.566	0.130	-0.187	0.043	0.550	0.345	906	.	.	.	ID=COSV54195956;OCCURENCE=1(large_intestine),1(lung)	OLFML2B	80	1	89	34	0.276422764227642	TRUE	TRUE
ENSG00000117501.14	.	BCM	GRCh38.p13	chr1	170998353	170998353	+	G	G	A	Missense_Mutation	SNP	ENST00000367758.7	exon15	c.G1675A	p.V559I	exonic	ENSG00000117501.14	.	nonsynonymous SNV	ENSG00000117501.14:ENST00000367758.7:exon15:c.G1675A:p.V559I	1q24.3	C3N-03439	0.0005	0	0.0003	0	0	0.0001	0	0.0029	rs200484356	0.19	T	T	B	B	N	N	N	T	N	0.070	T	T	T	0.009	.	0.014	.	.	T	T	T	T	T	-0.498	0.120	0.099	N	N	-1.545	0.068	-1.643	0.064	0.000	0.487	0.574	0.574	0.564	.	0.207	-0.414	-0.790	-0.416	-0.622	0.000	0.001	0.010	838	.	.	.	ID=COSV63009973;OCCURENCE=1(large_intestine)	MROH9	72	0	137	24	0.149068322981366	TRUE	NA
ENSG00000134369.15	.	BCM	GRCh38.p13	chr1	201718458	201718458	+	G	G	A	Missense_Mutation	SNP	ENST00000367296.8	exon3	c.G929A	p.R310H	exonic	ENSG00000134369.15	.	nonsynonymous SNV	ENSG00000134369.15:ENST00000367296.8:exon3:c.G929A:p.R310H	1q32.1	C3N-03439	.	.	.	.	.	.	.	.	.	11.18	D	D	.	.	N	D	M	T	D	0.746	T	T	D	0.318	0.176	0.690	2.339	D	T	T	T	D	D	4.375	31	1.000	D	D	0.770	8.219	0.733	8.421	1.000	0.707	0.624	0.616	0.714	.	5.580	4.660	9.300	1.176	0.676	1.000	1.000	0.998	790	.	.	.	ID=COSV99819567;OCCURENCE=1(upper_aerodigestive_tract)	NAV1	61	0	81	6	0.0689655172413793	TRUE	NA
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237595505	237595505	+	C	C	T	Missense_Mutation	SNP	ENST00000366574.7	exon34	c.C4444T	p.R1482C	exonic	ENSG00000198626.17	.	nonsynonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon34:c.C4444T:p.R1482C	1q43	C3N-03439	1.662e-05	0	0	0	0	1.502e-05	0	6.064e-05	rs564869863	11.19	T	.	D	P	N	D	M	T	D	0.743	T	T	D	0.330	.	0.495	1.325	D	D	T	T	D	D	3.839	26.000	0.999	D	D	0.638	6.337	0.628	6.589	0.999	0.638	0.574	0.653	0.564	.	5.000	5.000	3.985	1.016	0.587	1.000	1.000	1.000	934	0.000	.	.	ID=COSV63679506;OCCURENCE=1(breast),4(large_intestine),1(haematopoietic_and_lymphoid_tissue),2(pancreas)	RYR2	273	0	402	34	0.0779816513761468	TRUE	TRUE
ENSG00000134317.18	.	BCM	GRCh38.p13	chr2	10000697	10000697	+	C	C	T	Missense_Mutation	SNP	ENST00000324907.14	exon16	c.C1847T	p.T616M	exonic	ENSG00000134317.18	.	nonsynonymous SNV	ENSG00000134317.18:ENST00000324907.14:exon16:c.C1847T:p.T616M	2p25.1	C3N-03439	1.657e-05	0	0	0	0	3.011e-05	0	0	rs143356570	6.20	T	T	P	B	D	D	L	T	N	0.660	T	T	D	0.244	.	0.082	1.183	T	T	T	T	T	D	2.507	22.400	0.998	D	D	0.447	4.650	0.546	5.608	1.000	0.615	0.574	0.659	0.568	.	6.040	6.040	5.742	1.026	0.599	1.000	0.986	0.966	797	.	.	.	ID=COSV61215741;OCCURENCE=1(stomach)	GRHL1	71	0	137	13	0.0866666666666667	TRUE	TRUE
ENSG00000179915.23	.	BCM	GRCh38.p13	chr2	49943749	49943749	+	C	C	T	Missense_Mutation	SNP	ENST00000406316.6	exon21	c.G4081A	p.D1361N	exonic	ENSG00000179915.23	.	nonsynonymous SNV	ENSG00000179915.23:ENST00000406316.6:exon21:c.G4081A:p.D1361N	2p16.3	C3N-03439	.	.	.	.	.	.	.	.	.	11.20	D	D	P	B	U	D	M	T	D	0.825	T	T	D	0.394	0.293	0.849	1.557	D	T	T	T	D	D	3.281	24.100	0.999	D	D	0.581	5.732	0.643	6.809	1.000	0.638	0.574	0.653	0.564	.	5.810	5.810	7.848	1.026	0.599	1.000	0.985	0.967	910	.	.	.	ID=COSV60526410;OCCURENCE=1(skin)	NRXN1	314	0	506	54	0.0964285714285714	TRUE	TRUE
ENSG00000136535.15	.	BCM	GRCh38.p13	chr2	161423734	161423734	+	C	C	T	Missense_Mutation	SNP	ENST00000389554.8	exon6	c.C1556T	p.A519V	exonic	ENSG00000136535.15	.	nonsynonymous SNV	ENSG00000136535.15:ENST00000389554.8:exon6:c.C1556T:p.A519V	2q24.2	C3N-03439	.	.	.	.	.	.	.	.	.	16.20	D	T	D	D	U	D	M	D	N	0.526	D	D	D	0.554	0.472	0.471	.	D	T	D	D	D	D	3.710	25.400	0.999	D	D	0.395	4.314	0.326	3.871	1.000	0.598	0.596	0.607	0.604	.	3.570	3.570	5.308	0.866	0.452	1.000	0.995	0.981	699	T-box_transcription_factor-associated	.	.	.	TBR1	154	0	223	36	0.138996138996139	TRUE	TRUE
ENSG00000153253.18	.	BCM	GRCh38.p13	chr2	165091271	165091271	+	T	T	C	Missense_Mutation	SNP	ENST00000360093.7	exon28	c.A4882G	p.I1628V	exonic	ENSG00000153253.18	.	nonsynonymous SNV	ENSG00000153253.18:ENST00000360093.7:exon28:c.A4882G:p.I1628V	2q24.3	C3N-03439	.	.	.	.	.	.	.	.	.	17.20	D	T	D	D	D	D	L	D	N	0.587	D	D	D	0.653	0.629	0.911	0.899	D	D	D	D	D	D	3.603	25.000	0.997	D	D	0.519	5.188	0.610	6.354	1.000	0.487	0.574	0.574	0.564	.	6.070	6.070	7.960	1.138	0.609	1.000	0.997	0.980	812	Ion_transport_domain	.	.	.	SCN3A	383	0	565	62	0.0988835725677831	NA	TRUE
ENSG00000079308.19	.	BCM	GRCh38.p13	chr2	217809875	217809875	+	C	C	G	Missense_Mutation	SNP	ENST00000171887.8	exon30	c.G4909C	p.V1637L	exonic	ENSG00000079308.19	.	nonsynonymous SNV	ENSG00000079308.19:ENST00000171887.8:exon30:c.G4909C:p.V1637L	2q35	C3N-03439	.	.	.	.	.	.	.	.	.	14.20	D	D	B	B	D	D	M	T	D	0.793	T	T	D	0.408	0.622	0.487	0.123	D	T	D	D	D	D	3.154	23.800	0.993	D	D	0.235	3.463	0.264	3.516	1.000	0.707	0.590	0.659	0.714	.	4.380	3.500	7.774	0.918	0.564	1.000	1.000	1.000	940	Tensin,_phosphotyrosine-binding_domain;PTB/PI_domain;Tensin/EPS8_phosphotyrosine-binding_domain	.	.	.	TNS1	170	0	250	22	0.0808823529411765	TRUE	TRUE
ENSG00000124006.15	.	BCM	GRCh38.p13	chr2	219559317	219559317	+	C	C	T	Missense_Mutation	SNP	ENST00000404537.6	exon9	c.G3134A	p.R1045H	exonic	ENSG00000124006.15	.	nonsynonymous SNV	ENSG00000124006.15:ENST00000404537.6:exon9:c.G3134A:p.R1045H	2q35	C3N-03439	1.657e-05	0	0	0	0	2.999e-05	0	0	rs750084343	11.19	D	D	D	D	.	D	L	T	D	0.701	T	T	D	0.171	.	0.491	0.735	T	T	T	T	D	D	3.664	25.300	1.000	D	D	0.526	5.247	0.469	4.884	1.000	0.635	0.574	0.644	0.586	.	4.340	4.340	6.038	1.026	0.549	1.000	0.964	0.884	114	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV54707421;OCCURENCE=1(liver),1(large_intestine)	OBSL1	193	0	281	38	0.119122257053292	TRUE	TRUE
ENSG00000182177.14	.	BCM	GRCh38.p13	chr2	236195057	236195057	+	T	T	C	Missense_Mutation	SNP	ENST00000409749.7	exon6	c.A1216G	p.M406V	exonic	ENSG00000182177.14	.	nonsynonymous SNV	ENSG00000182177.14:ENST00000409749.7:exon6:c.A1216G:p.M406V	2q37.2	C3N-03439	1.787e-05	0.0001	9.404e-05	0	0	0	0	0	rs757623786	0.19	T	T	B	B	.	N	L	T	N	0.099	T	T	T	0.033	.	0.081	0.082	T	T	T	T	T	T	1.151	13.230	0.851	N	N	-0.777	0.688	-0.662	0.955	0.005	0.497	0.590	0.547	0.613	.	4.640	0.762	-0.068	1.138	0.665	0.473	0.968	0.941	987	SOCS_box_domain	.	.	.	ASB18	61	0	77	11	0.125	TRUE	NA
ENSG00000182973.18	.	BCM	GRCh38.p13	chr3	32720117	32720117	+	G	G	A	Missense_Mutation	SNP	ENST00000328834.9	exon8	c.G748A	p.A250T	exonic	ENSG00000182973.18	.	nonsynonymous SNV	ENSG00000182973.18:ENST00000328834.9:exon8:c.G748A:p.A250T	3p22.3	C3N-03439	0	0	0	0	0	0	0	0	rs752322117	6.20	T	T	B	B	D	D	N	T	N	0.487	T	T	T	0.215	0.243	0.468	0.263	D	T	T	T	T	D	2.695	22.800	0.983	D	D	-0.035	2.390	0.214	3.254	1.000	0.732	0.744	0.710	0.728	.	5.910	5.910	6.898	1.167	0.676	1.000	0.998	0.985	752	.	.	.	ID=COSV59391121;OCCURENCE=1(large_intestine),1(stomach)	CNOT10	25	0	53	8	0.131147540983607	TRUE	TRUE
ENSG00000174004.6	.	BCM	GRCh38.p13	chr3	196660371	196660371	+	C	C	T	Missense_Mutation	SNP	ENST00000328557.5	exon3	c.C728T	p.A243V	exonic	ENSG00000174004.6	.	nonsynonymous SNV	ENSG00000174004.6:ENST00000328557.5:exon3:c.C728T:p.A243V	3q29	C3N-03439	.	.	.	.	.	.	.	.	rs572343955	8.19	D	T	D	P	D	D	.	T	N	0.343	T	T	D	0.325	0.643	0.401	1.148	T	T	T	T	D	T	3.051	23.500	0.999	D	D	0.459	4.731	0.470	4.893	1.000	0.706	0.698	0.710	0.636	.	5.950	5.950	6.144	1.026	0.599	1.000	0.276	0.037	501	.	.	.	ID=COSV60746064;OCCURENCE=1(large_intestine),1(stomach)	NRROS	246	0	333	44	0.116710875331565	TRUE	TRUE
ENSG00000007062.11	.	BCM	GRCh38.p13	chr4	16013299	16013299	+	G	G	A	Missense_Mutation	SNP	ENST00000510224.5	exon11	c.C1117T	p.R373C	exonic	ENSG00000007062.11	.	nonsynonymous SNV	ENSG00000007062.11:ENST00000510224.5:exon11:c.C1117T:p.R373C	4p15.32	C3N-03439	.	.	.	.	.	.	.	.	rs137853006	5.20	D	D	P	B	N	A	N	T	D	0.670	T	T	T	0.281	0.819	0.561	0.018	T	D	T	T	T	T	0.915	10.590	0.923	N	N	-1.187	0.236	-1.264	0.234	0.059	0.707	0.590	0.725	0.542	.	5.030	-0.568	0.303	-0.580	-1.616	0.001	0.021	0.000	923	.	.	.	ID=COSV101477144;OCCURENCE=1(large_intestine)	PROM1	103	0	197	11	0.0528846153846154	TRUE	NA
ENSG00000145337.5	.	BCM	GRCh38.p13	chr4	88521955	88521955	+	T	T	A	Missense_Mutation	SNP	ENST00000273968.5	exon2	c.A278T	p.N93I	exonic	ENSG00000145337.5	.	nonsynonymous SNV	ENSG00000145337.5:ENST00000273968.5:exon2:c.A278T:p.N93I	4q22.1	C3N-03439	.	.	.	.	.	.	.	.	.	10.18	T	T	D	D	D	.	N	.	D	0.743	T	T	T	0.600	0.453	0.458	.	T	T	D	D	D	D	4.060	27.400	0.937	D	D	0.278	3.666	0.289	3.654	1.000	0.706	0.581	0.710	0.651	.	4.860	3.650	7.032	0.966	0.661	1.000	1.000	0.998	796	.	.	.	.	PYURF	122	0	204	11	0.0511627906976744	TRUE	TRUE
ENSG00000212122.4	.	BCM	GRCh38.p13	chr5	113434716	113434716	+	T	T	A	Missense_Mutation	SNP	ENST00000390666.4	exon1	c.A124T	p.I42F	exonic	ENSG00000212122.4	.	nonsynonymous SNV	ENSG00000212122.4:ENST00000390666.4:exon1:c.A124T:p.I42F	5q22.2	C3N-03439	.	.	.	.	.	.	.	.	.	9.20	D	D	D	D	U	D	L	T	D	0.382	T	T	T	0.265	0.727	0.454	0.625	T	T	T	T	D	D	2.677	22.800	0.989	D	N	0.365	4.133	0.243	3.401	0.468	0.497	0.590	0.547	0.542	.	2.670	2.670	2.690	0.634	0.665	1.000	0.163	0.781	922	Protein_kinase_domain	.	.	.	TSSK1B	256	0	353	32	0.0831168831168831	TRUE	TRUE
ENSG00000221900.6	.	BCM	GRCh38.p13	chr7	53035885	53035885	+	G	G	A	Missense_Mutation	SNP	ENST00000408890.6	exon1	c.G214A	p.V72M	exonic	ENSG00000221900.6	.	nonsynonymous SNV	ENSG00000221900.6:ENST00000408890.6:exon1:c.G214A:p.V72M	7p12.1	C3N-03439	.	.	.	.	.	.	.	.	.	1.19	D	T	P	B	.	N	N	T	N	0.108	T	T	T	0.100	0.095	0.040	0.089	T	T	T	T	T	T	0.259	3.811	0.886	N	N	-1.115	0.293	-1.276	0.225	0.000	0.487	0.574	0.547	0.564	.	1.940	-1.490	-0.333	0.597	0.347	0.000	0.008	0.003	981	.	.	.	.	POM121L12	247	0	391	29	0.0690476190476191	TRUE	TRUE
ENSG00000158321.18	.	BCM	GRCh38.p13	chr7	69899325	69899325	+	C	C	T	Missense_Mutation	SNP	ENST00000342771.10	exon2	c.C349T	p.R117C	exonic	ENSG00000158321.18	.	nonsynonymous SNV	ENSG00000158321.18:ENST00000342771.10:exon2:c.C349T:p.R117C	7q11.22	C3N-03439	0.0002	0.0013	0.0002	0.0003	0	0	0	0	rs142957106	6.20	D	D	P	B	N	D	L	T	D	0.523	T	T	T	0.093	.	0.139	0.750	T	T	T	T	T	D	2.497	22.400	0.998	D	N	0.220	3.392	0.289	3.652	1.000	0.722	0.699	0.618	0.564	.	5.650	4.750	1.563	1.026	0.599	0.975	0.988	0.995	755	.	.	.	ID=COSV61384925;OCCURENCE=1(breast),1(oesophagus),2(biliary_tract),1(stomach),1(prostate)	AUTS2	292	0	408	35	0.0790067720090293	TRUE	TRUE
ENSG00000186088.16	.	BCM	GRCh38.p13	chr7	77323683	77323683	+	T	T	G	Missense_Mutation	SNP	ENST00000257626.12	exon24	c.A1887C	p.K629N	exonic	ENSG00000186088.16	.	nonsynonymous SNV	ENSG00000186088.16:ENST00000257626.12:exon24:c.A1887C:p.K629N	7q11.23	C3N-03439	.	.	.	.	.	.	.	.	.	5.20	D	T	B	B	D	D	L	T	N	0.518	T	T	T	0.093	0.322	0.208	0.276	T	T	T	T	D	T	2.466	22.300	0.996	D	N	-0.020	2.441	0.063	2.589	1.000	0.651	0.709	0.602	0.568	.	5.480	3.060	1.740	1.138	0.665	1.000	1.000	0.999	449	.	.	.	.	GSAP	108	0	166	14	0.0777777777777778	TRUE	TRUE
ENSG00000019991.18	.	BCM	GRCh38.p13	chr7	81707361	81707361	+	A	A	C	Missense_Mutation	SNP	ENST00000222390.11	exon14	c.T1545G	p.N515K	exonic	ENSG00000019991.18	.	nonsynonymous SNV	ENSG00000019991.18:ENST00000222390.11:exon14:c.T1545G:p.N515K	7q21.11	C3N-03439	.	.	.	.	.	.	.	.	.	9.20	T	T	D	P	D	D	N	D	N	0.444	T	T	D	0.514	0.768	0.839	0.614	T	D	T	T	D	T	2.957	23.300	0.996	D	D	0.393	4.301	0.430	4.581	1.000	0.487	0.574	0.574	0.564	.	5.550	4.400	2.244	1.288	0.756	1.000	1.000	1.000	826	Serine_proteases,_trypsin_domain	.	.	.	HGF	217	1	373	24	0.0604534005037783	TRUE	TRUE
ENSG00000001626.16	.	BCM	GRCh38.p13	chr7	117602835	117602835	+	T	T	G	Missense_Mutation	SNP	ENST00000003084.11	exon16	c.T2629G	p.S877A	exonic	ENSG00000001626.16	.	nonsynonymous SNV	ENSG00000001626.16:ENST00000003084.11:exon16:c.T2629G:p.S877A	7q31.2	C3N-03439	1.647e-05	0	0	0	0	0	0	0.0001	rs761531223	11.20	T	D	B	B	D	D	M	D	N	0.510	D	D	D	0.435	0.554	0.994	0.004	T	T	T	D	T	T	1.674	16.850	0.983	D	D	0.020	2.582	0.050	2.539	1.000	0.554	0.574	0.602	0.564	.	5.920	5.920	4.633	1.134	0.661	0.998	0.980	0.635	857	ABC_transporter_type_1,_transmembrane_domain	.	.	.	CFTR	487	2	590	191	0.244558258642766	TRUE	NA
ENSG00000168079.17	.	BCM	GRCh38.p13	chr8	27922045	27922045	+	G	G	A	Missense_Mutation	SNP	ENST00000354914.8	exon4	c.C442T	p.R148W	exonic	ENSG00000168079.17	.	nonsynonymous SNV	ENSG00000168079.17:ENST00000354914.8:exon4:c.C442T:p.R148W	8p21.1	C3N-03439	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	N	D	L	D	D	0.568	D	D	D	0.572	0.439	0.900	0.808	T	T	D	T	D	D	3.235	24.000	0.981	D	D	-0.385	1.416	-0.443	1.297	1.000	0.497	0.590	0.578	0.542	.	4.560	-0.473	0.318	-0.265	-0.199	0.404	0.993	0.968	851	.	.	.	ID=COSV57276967;OCCURENCE=1(breast),1(pancreas)	SCARA5	89	0	124	11	0.0814814814814815	NA	TRUE
ENSG00000122733.12	.	BCM	GRCh38.p13	chr9	34971555	34971555	+	G	G	A	Missense_Mutation	SNP	ENST00000242315.3	exon2	c.G257A	p.R86H	exonic	ENSG00000122733.12	.	nonsynonymous SNV	ENSG00000122733.12:ENST00000242315.3:exon2:c.G257A:p.R86H	9p13.3	C3N-03439	.	.	.	.	.	.	.	.	.	10.18	D	D	D	D	D	D	.	.	N	0.318	T	T	T	0.148	0.225	0.467	1.276	T	T	T	T	D	D	3.695	25.400	1.000	D	D	0.721	7.421	0.738	8.528	1.000	0.554	0.590	0.602	0.542	.	6.030	6.030	5.172	1.176	0.676	1.000	0.979	0.901	268	.	.	.	.	PHF24	252	0	332	27	0.0752089136490251	TRUE	TRUE
ENSG00000154330.13	.	BCM	GRCh38.p13	chr9	68357240	68357240	+	G	G	A	Missense_Mutation	SNP	ENST00000396396.6	exon1	c.G113A	p.R38H	exonic	ENSG00000154330.13	.	nonsynonymous SNV	ENSG00000154330.13:ENST00000396396.6:exon1:c.G113A:p.R38H	9q21.11	C3N-03439	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	U	D	L	T	N	0.271	T	T	D	0.180	0.559	0.043	2.782	D	T	T	T	D	D	4.128	28.000	0.999	D	N	0.220	3.391	0.191	3.141	0.928	0.583	0.476	0.608	0.621	.	3.120	3.120	0.717	0.969	-0.373	0.930	0.998	0.882	988	Alpha-D-phosphohexomutase,_alpha/beta/alpha_domain_I	.	.	.	PGM5	223	0	355	39	0.0989847715736041	NA	TRUE
ENSG00000185585.20	.	BCM	GRCh38.p13	chr9	124807942	124807942	+	C	C	T	Missense_Mutation	SNP	ENST00000373580.8	exon7	c.C1330T	p.R444C	exonic	ENSG00000185585.20	.	nonsynonymous SNV	ENSG00000185585.20:ENST00000373580.8:exon7:c.C1330T:p.R444C	9q33.3	C3N-03439	2.481e-05	0	0	0	0	1.503e-05	0	0.0001	rs765039347	19.20	D	D	D	D	D	D	M	D	D	0.970	D	D	D	0.763	0.731	0.749	0.598	T	D	D	D	D	D	4.166	28.300	0.999	D	D	0.805	8.877	0.772	9.358	1.000	0.646	0.588	0.645	0.613	.	5.680	5.680	4.086	1.022	0.596	1.000	0.984	0.995	828	Olfactomedin-like_domain	.	.	ID=COSV56584456;OCCURENCE=1(large_intestine)	OLFML2A	102	0	129	10	0.0719424460431655	TRUE	TRUE
ENSG00000130635.16	.	BCM	GRCh38.p13	chr9	134701256	134701256	+	C	C	T	Missense_Mutation	SNP	ENST00000371817.8	exon4	c.C577T	p.R193C	exonic	ENSG00000130635.16	.	nonsynonymous SNV	ENSG00000130635.16:ENST00000371817.8:exon4:c.C577T:p.R193C	9q34.3	C3N-03439	8.397e-06	0	0	0	0	1.529e-05	0	0	rs765170704	17.20	D	D	D	D	U	D	H	T	D	0.921	D	D	D	0.785	0.833	0.908	0.755	T	D	D	D	D	D	3.549	24.900	0.998	D	D	0.728	7.528	0.614	6.405	1.000	0.672	0.590	0.805	0.711	.	5.070	5.070	1.457	1.026	0.549	0.742	0.309	0.211	940	Laminin_G_domain	.	.	ID=COSV65667693;OCCURENCE=1(stomach),1(haematopoietic_and_lymphoid_tissue),1(urinary_tract),1(lung)	COL5A1	536	0	665	68	0.0927694406548431	TRUE	TRUE
ENSG00000175216.15	.	BCM	GRCh38.p13	chr11	46778259	46778259	+	A	A	C	Missense_Mutation	SNP	ENST00000529230.6	exon22	c.T2628G	p.I876M	exonic	ENSG00000175216.15	.	nonsynonymous SNV	ENSG00000175216.15:ENST00000529230.6:exon22:c.T2628G:p.I876M	11p11.2	C3N-03439	.	.	.	.	.	.	.	.	.	9.20	T	D	D	D	D	D	L	T	N	0.611	T	T	T	0.370	0.492	0.635	0.774	T	T	D	T	D	D	2.676	22.800	0.993	D	N	-0.094	2.194	-0.145	1.923	0.138	0.707	0.725	0.725	0.711	.	5.690	-2.400	1.141	-0.157	-0.156	1.000	0.997	0.996	12	CLASP_N-terminal_domain;TOG_domain	.	.	.	CKAP5	188	1	276	18	0.0612244897959184	TRUE	TRUE
ENSG00000176200.1	.	BCM	GRCh38.p13	chr11	59503853	59503853	+	C	C	A	Missense_Mutation	SNP	ENST00000313253.1	exon1	c.C278A	p.S93Y	exonic	ENSG00000176200.1	.	nonsynonymous SNV	ENSG00000176200.1:ENST00000313253.1:exon1:c.C278A:p.S93Y	11q12.1	C3N-03439	4.119e-05	0	0	0	0	7.493e-05	0	0	rs371625986	8.20	D	D	D	P	D	N	H	T	D	0.782	T	T	T	0.170	.	0.723	0.046	T	T	T	T	D	D	2.539	22.500	0.993	N	N	0.593	5.857	0.472	4.915	0.843	0.428	0.469	0.547	0.613	.	5.440	5.440	1.839	1.022	0.526	0.425	0.087	0.945	308	GPCR,_rhodopsin-like,_7TM	.	.	.	OR4D11	159	0	278	26	0.0855263157894737	TRUE	NA
ENSG00000110446.11	.	BCM	GRCh38.p13	chr11	60946791	60946791	+	G	G	A	Missense_Mutation	SNP	ENST00000227880.8	exon2	c.C589T	p.R197C	exonic	ENSG00000110446.11	.	nonsynonymous SNV	ENSG00000110446.11:ENST00000227880.8:exon2:c.C589T:p.R197C	11q12.2	C3N-03439	0.0007	0	0	0.0006	0	0	0.0022	0.0051	rs528183979	12.20	D	D	D	D	D	D	M	T	D	0.653	T	T	D	0.520	0.703	0.773	0.576	T	T	T	D	T	D	4.080	27.600	0.999	D	N	0.525	5.239	0.448	4.717	1.000	0.696	0.672	0.723	0.542	.	4.650	3.720	1.763	1.065	0.597	0.977	0.997	0.970	596	.	.	.	ID=COSV99928610;OCCURENCE=1(endometrium)	SLC15A3	122	0	181	19	0.095	TRUE	NA
ENSG00000196248.5	.	BCM	GRCh38.p13	chr11	123977189	123977189	+	G	G	A	Missense_Mutation	SNP	ENST00000531945.1	exon1	c.C503T	p.T168M	exonic	ENSG00000196248.5	.	nonsynonymous SNV	ENSG00000196248.5:ENST00000531945.1:exon1:c.C503T:p.T168M	11q24.1	C3N-03439	4.119e-05	0	0	0	0	7.493e-05	0	0	rs777181185	0.20	T	T	B	B	N	N	N	T	N	0.046	T	T	T	0.012	0.382	0.099	0.082	T	T	T	T	T	T	0.143	2.501	0.891	N	N	-1.331	0.149	-1.329	0.191	0.947	0.487	0.574	0.574	0.613	.	4.890	-1.720	1.650	-0.182	-0.363	0.041	0.002	0.216	848	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV73343037;OCCURENCE=1(prostate)	OR10S1	251	0	367	51	0.12200956937799	TRUE	TRUE
ENSG00000151079.7	.	BCM	GRCh38.p13	chr12	4810439	4810439	+	C	C	T	Missense_Mutation	SNP	ENST00000280684.3	exon1	c.C398T	p.A133V	exonic	ENSG00000151079.7	.	nonsynonymous SNV	ENSG00000151079.7:ENST00000280684.3:exon1:c.C398T:p.A133V	12p13.32	C3N-03439	.	.	.	.	.	.	.	.	.	5.20	D	T	B	B	N	D	L	T	N	0.165	T	T	D	0.224	0.548	0.464	1.573	T	T	T	T	D	D	1.859	18.170	0.998	N	N	-0.191	1.903	-0.105	2.031	1.000	0.658	0.542	0.619	0.616	.	4.870	4.870	-0.186	0.125	-0.180	0.000	0.944	0.788	814	BTB/POZ_domain	.	.	.	KCNA6	278	0	376	49	0.115294117647059	TRUE	TRUE
ENSG00000173262.11	.	BCM	GRCh38.p13	chr12	7831632	7831632	+	C	C	T	Missense_Mutation	SNP	ENST00000543909.5	exon9	c.G313A	p.V105I	exonic	ENSG00000173262.11	.	nonsynonymous SNV	ENSG00000173262.11:ENST00000543909.5:exon9:c.G313A:p.V105I	12p13.31	C3N-03439	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.445	T	T	T	0.339	0.740	0.300	0.308	T	T	T	T	D	D	1.501	15.740	0.995	D	D	-0.107	2.152	-0.001	2.354	1.000	0.625	0.574	0.650	0.613	.	3.600	3.600	5.189	0.753	0.306	1.000	0.809	0.075	929	Major_facilitator_superfamily_domain	.	.	ID=COSV61587737;OCCURENCE=1(large_intestine),1(ovary),1(urinary_tract),1(kidney)	SLC2A14	166	0	230	24	0.094488188976378	NA	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-03439	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	282	0	405	42	0.0939597315436242	TRUE	TRUE
ENSG00000139211.6	.	BCM	GRCh38.p13	chr12	47077867	47077867	+	G	G	A	Missense_Mutation	SNP	ENST00000266581.4	exon2	c.C1136T	p.T379I	exonic	ENSG00000139211.6	.	nonsynonymous SNV	ENSG00000139211.6:ENST00000266581.4:exon2:c.C1136T:p.T379I	12q13.11	C3N-03439	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	N	L	D	N	0.208	T	D	D	0.177	0.430	0.546	0.657	T	T	T	T	T	T	2.294	21.500	0.986	D	N	-0.311	1.588	-0.162	1.880	1.000	0.644	0.563	0.645	0.632	.	5.020	3.000	1.546	0.236	0.662	0.918	0.932	0.997	647	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	AMIGO2	162	0	252	18	0.0666666666666667	TRUE	TRUE
ENSG00000123384.14	.	BCM	GRCh38.p13	chr12	57143715	57143715	+	A	A	G	Missense_Mutation	SNP	ENST00000243077.8	exon4	c.A365G	p.H122R	exonic	ENSG00000123384.14	.	nonsynonymous SNV	ENSG00000123384.14:ENST00000243077.8:exon4:c.A365G:p.H122R	12q13.3	C3N-03439	.	.	.	.	.	.	.	.	.	14.20	D	D	P	B	N	D	M	D	D	0.450	D	D	D	0.241	0.606	0.802	.	T	T	D	D	D	T	2.985	23.400	0.987	D	D	0.187	3.248	0.278	3.593	1.000	0.707	0.610	0.725	0.616	.	4.810	4.810	4.132	1.312	0.756	1.000	1.000	1.000	237	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	LRP1	173	1	247	24	0.0885608856088561	TRUE	TRUE
ENSG00000118600.12	.	BCM	GRCh38.p13	chr12	63808983	63808983	+	T	T	A	Missense_Mutation	SNP	ENST00000261234.11	exon6	c.T1223A	p.I408N	exonic	ENSG00000118600.12	.	nonsynonymous SNV	ENSG00000118600.12:ENST00000261234.11:exon6:c.T1223A:p.I408N	12q14.2	C3N-03439	.	.	.	.	.	.	.	.	.	10.18	D	D	D	P	D	D	.	.	D	0.627	T	T	T	0.189	0.421	0.165	0.763	T	T	T	T	D	D	3.891	26.300	0.994	D	D	0.554	5.487	0.540	5.545	0.994	0.732	0.744	0.602	0.613	.	4.960	4.960	4.457	1.138	0.665	1.000	1.000	0.234	922	.	.	.	.	RXYLT1	146	0	242	34	0.123188405797101	TRUE	TRUE
ENSG00000110987.9	.	BCM	GRCh38.p13	chr12	122054913	122054913	+	C	C	T	Missense_Mutation	SNP	ENST00000261822.5	exon5	c.C548T	p.S183F	exonic	ENSG00000110987.9	.	nonsynonymous SNV	ENSG00000110987.9:ENST00000261822.5:exon5:c.C548T:p.S183F	12q24.31	C3N-03439	.	.	.	.	.	.	.	.	.	8.19	D	D	D	D	N	N	M	T	N	0.493	T	T	D	0.161	0.294	0.558	0.915	T	T	T	T	D	.	3.581	25.000	0.996	D	N	-0.133	2.074	-0.166	1.870	1.000	0.707	0.654	0.725	0.636	.	6.070	4.220	3.797	0.947	0.599	0.871	0.952	0.768	722	.	.	.	.	BCL7A	233	0	316	36	0.102272727272727	TRUE	TRUE
ENSG00000133103.17	.	BCM	GRCh38.p13	chr13	39659447	39659447	+	T	T	G	Missense_Mutation	SNP	ENST00000455146.8	exon2	c.T237G	p.I79M	exonic	ENSG00000133103.17	.	nonsynonymous SNV	ENSG00000133103.17:ENST00000455146.8:exon2:c.T237G:p.I79M	13q14.11	C3N-03439	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.956	T	T	D	0.446	0.737	0.460	0.352	T	T	D	D	D	D	3.136	23.700	0.716	D	N	0.323	3.901	0.235	3.358	1.000	0.706	0.710	0.659	0.613	.	5.430	1.490	0.352	1.138	0.665	0.999	0.998	0.997	672	.	.	.	.	COG6	229	0	340	40	0.105263157894737	TRUE	TRUE
ENSG00000102466.15	.	BCM	GRCh38.p13	chr13	101916462	101916462	+	G	G	A	Missense_Mutation	SNP	ENST00000376143.4	exon1	c.C184T	p.R62W	exonic	ENSG00000102466.15	.	nonsynonymous SNV	ENSG00000102466.15:ENST00000376143.4:exon1:c.C184T:p.R62W	13q33.1	C3N-03439	.	.	.	.	.	.	.	.	rs868433062	14.18	D	D	D	D	.	D	L	T	D	0.535	D	D	D	0.511	0.495	0.667	.	.	D	T	T	D	D	1.908	18.550	0.999	D	D	0.378	4.208	0.308	3.765	1.000	0.598	0.616	0.607	0.639	.	5.360	4.510	1.327	0.190	0.676	1.000	1.000	0.999	874	.	.	.	ID=COSV65951449;OCCURENCE=3(stomach),1(urinary_tract)	FGF14	558	0	775	70	0.0828402366863905	TRUE	TRUE
ENSG00000182107.7	.	BCM	GRCh38.p13	chr14	61280247	61280247	+	G	G	A	Missense_Mutation	SNP	ENST00000555868.2	exon1	c.C901T	p.L301F	exonic	ENSG00000182107.7	.	nonsynonymous SNV	ENSG00000182107.7:ENST00000555868.2:exon1:c.C901T:p.L301F	14q23.1	C3N-03439	.	.	.	.	.	.	.	.	.	4.19	D	D	B	B	N	N	L	.	N	0.114	T	T	T	0.092	0.535	0.030	.	T	T	T	T	D	T	3.253	24.000	0.991	D	N	-0.188	1.910	-0.070	2.134	1.000	0.789	0.563	0.768	0.555	.	4.670	3.760	2.780	1.176	0.676	0.998	0.980	1.000	301	.	.	.	ID=COSV63133081;OCCURENCE=1(oesophagus)	TMEM30B	274	0	360	38	0.0954773869346734	TRUE	TRUE
ENSG00000100596.6	.	BCM	GRCh38.p13	chr14	77512298	77512298	+	C	C	T	Missense_Mutation	SNP	ENST00000216484.6	exon12	c.G1675A	p.E559K	exonic	ENSG00000100596.6	.	nonsynonymous SNV	ENSG00000100596.6:ENST00000216484.6:exon12:c.G1675A:p.E559K	14q24.3	C3N-03439	.	.	.	.	.	.	.	.	.	13.20	D	T	P	B	D	D	L	D	N	0.689	D	D	D	0.628	0.451	0.649	0.593	T	T	D	D	D	D	3.159	23.800	0.999	D	D	0.293	3.741	0.428	4.559	1.000	0.707	0.725	0.725	0.711	.	5.560	5.560	5.600	1.026	0.599	1.000	0.978	0.818	806	.	.	.	.	SPTLC2	391	0	632	73	0.10354609929078	TRUE	TRUE
ENSG00000137766.17	.	BCM	GRCh38.p13	chr15	54015642	54015642	+	T	T	-	Frame_Shift_Del	NA	ENST00000260323.15	exon1	c.2739delT	p.Y914Mfs*22	exonic	ENSG00000137766.17	.	frameshift deletion	ENSG00000137766.17:ENST00000260323.15:exon1:c.2739delT:p.Y914Mfs*22	15q21.3	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UNC13C	53	0	95	7	0.0686274509803922	NA	TRUE
ENSG00000182854.8	.	BCM	GRCh38.p13	chr15	101819082	101819082	+	G	G	A	Missense_Mutation	SNP	ENST00000332238.5	exon2	c.G896A	p.R299K	exonic	ENSG00000182854.8	.	nonsynonymous SNV	ENSG00000182854.8:ENST00000332238.5:exon2:c.G896A:p.R299K	15q26.3	C3N-03439	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.029	T	T	T	0.106	0.522	0.197	0.010	T	T	T	T	T	T	0.342	4.775	0.592	N	N	-0.942	0.469	-0.916	0.598	0.000	0.487	0.574	0.574	0.564	.	5.460	-0.465	-0.848	-0.584	0.671	0.000	0.364	0.299	819	.	.	.	.	OR4F15	81	0	145	10	0.0645161290322581	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674872	7674872	+	T	T	C	Missense_Mutation	SNP	ENST00000269305.8	exon6	c.A659G	p.Y220C	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon6:c.A659G:p.Y220C	17p13.1	C3N-03439	2.503e-05	0	0	0	0	4.543e-05	0	0	rs121912666	19.20	D	D	D	D	D	D	M	D	D	0.914	D	D	D	0.936	0.938	0.982	1.856	T	D	D	D	D	D	4.457	32	0.998	D	D	0.750	7.886	0.664	7.134	1.000	0.732	0.698	0.744	0.735	.	5.280	5.280	6.252	1.138	0.665	1.000	0.994	0.998	433	p53,_DNA-binding_domain	.	.	ID=COSV52661282;OCCURENCE=4(salivary_gland),70(breast),1(penis),1(peritoneum),15(liver),48(oesophagus),38(large_intestine),35(central_nervous_system),3(biliary_tract),1(vulva),63(ovary),1(pleura),2(bone),1(NS),29(stomach),56(haematopoietic_and_lymphoid_tissue),2(kidney),18(urinary_tract),14(soft_tissue),17(pancreas),1(pituitary),2(skin),20(prostate),51(lung),4(thyroid),43(upper_aerodigestive_tract),3(small_intestine),12(endometrium)	TP53	351	0	401	48	0.106904231625835	TRUE	TRUE
ENSG00000062725.10	.	BCM	GRCh38.p13	chr17	60466292	60466292	+	T	T	C	Missense_Mutation	SNP	ENST00000083182.8	exon5	c.A671G	p.E224G	exonic	ENSG00000062725.10	.	nonsynonymous SNV	ENSG00000062725.10:ENST00000083182.8:exon5:c.A671G:p.E224G	17q23.2	C3N-03439	.	.	.	.	.	.	.	.	.	13.20	D	T	P	P	D	D	L	T	D	0.862	D	D	D	0.769	0.467	0.864	1.417	T	T	D	D	D	D	5.031	33	0.997	D	D	0.557	5.511	0.581	5.991	1.000	0.706	0.725	0.710	0.714	.	5.150	5.150	7.578	1.138	0.665	1.000	1.000	0.993	662	.	.	.	.	APPBP2	78	0	165	21	0.112903225806452	TRUE	TRUE
ENSG00000206432.4	.	BCM	GRCh38.p13	chr18	5890974	5890974	+	G	G	A	Missense_Mutation	SNP	ENST00000581347.2	exon3	c.C1090T	p.R364C	exonic	ENSG00000206432.4	.	nonsynonymous SNV	ENSG00000206432.4:ENST00000581347.2:exon3:c.C1090T:p.R364C	18p11.31	C3N-03439	.	.	.	.	.	.	.	.	.	10.18	D	D	D	P	.	D	L	.	D	0.314	T	T	D	0.227	0.136	0.281	.	D	T	T	T	D	T	4.512	32	0.999	D	D	0.206	3.330	0.227	3.317	1.000	0.652	0.541	0.641	0.555	.	3.630	3.630	4.193	0.873	0.502	0.984	1.000	0.995	981	.	.	.	.	TMEM200C	237	0	285	22	0.0716612377850163	TRUE	TRUE
ENSG00000250799.10	.	BCM	GRCh38.p13	chr19	35802191	35802191	+	C	C	A	Missense_Mutation	SNP	ENST00000301175.7	exon10	c.G1426T	p.G476W	exonic	ENSG00000250799.10	.	nonsynonymous SNV	ENSG00000250799.10:ENST00000301175.7:exon10:c.G1426T:p.G476W	19q13.12	C3N-03439	.	.	.	.	.	.	.	.	.	12.18	D	D	D	D	.	D	.	T	D	0.652	T	T	T	0.408	0.726	0.546	0.666	T	D	D	D	D	T	5.874	35	0.995	D	D	0.888	10.737	0.822	10.815	1.000	0.497	0.590	0.547	0.542	.	5.200	5.200	6.447	1.026	0.599	1.000	0.943	0.777	729	Proline_dehydrogenase_domain	.	.	.	PRODH2	189	0	346	41	0.10594315245478	TRUE	TRUE
ENSG00000154734.15	.	BCM	GRCh38.p13	chr21	26840001	26840001	+	C	C	T	Missense_Mutation	SNP	ENST00000284984.8	exon6	c.G1726A	p.G576S	exonic	ENSG00000154734.15	.	nonsynonymous SNV	ENSG00000154734.15:ENST00000284984.8:exon6:c.G1726A:p.G576S	21q21.3	C3N-03439	0.0006	0.0064	0.0003	0.0001	0	8.997e-05	0	0	rs146313892	14.19	D	D	D	D	.	D	M	T	D	0.855	D	D	D	0.646	.	0.818	0.887	T	T	T	D	T	D	3.561	24.900	0.998	D	D	0.854	9.919	0.743	8.647	1.000	0.707	0.574	0.702	0.714	.	5.110	5.110	7.568	1.026	0.599	1.000	0.928	0.127	828	.	.	.	ID=COSV99535701;OCCURENCE=1(breast)	ADAMTS1	154	1	212	17	0.074235807860262	TRUE	NA
ENSG00000147118.12	.	BCM	GRCh38.p13	chrX	47977228	47977228	+	C	C	A	Nonsense_Mutation	SNP	ENST00000396965.5	exon7	c.G859T	p.E287X	exonic	ENSG00000147118.12	.	stopgain	ENSG00000147118.12:ENST00000396965.5:exon7:c.G859T:p.E287X	Xp11.23	C3N-03439	.	.	.	.	.	.	.	.	.	3.4	.	.	.	.	.	D	.	.	.	0.212	.	.	.	.	.	.	.	.	.	D	D	.	.	6.399	36	0.997	N	.	.	.	.	.	0.886	.	.	.	.	.	4.530	3.670	5.876	0.962	0.524	1.000	0.998	0.997	595	Zinc_finger_C2H2-type	.	.	.	ZNF182	112	0	157	16	0.092485549132948	TRUE	TRUE
ENSG00000187690.4	.	BCM	GRCh38.p13	chrX	51407455	51407455	+	C	C	T	Missense_Mutation	SNP	ENST00000342995.4	exon1	c.C439T	p.R147C	exonic	ENSG00000187690.4	.	nonsynonymous SNV	ENSG00000187690.4:ENST00000342995.4:exon1:c.C439T:p.R147C	Xp11.22	C3N-03439	.	.	.	.	.	.	.	.	.	3.17	D	T	P	B	N	N	.	T	D	0.165	T	T	T	0.088	0.145	0.204	0.158	.	T	T	T	D	T	0.858	9.986	0.955	N	.	.	.	.	.	0.000	.	.	.	.	.	3.080	-0.987	-0.961	-0.614	-0.222	0.000	0.001	0.007	242	.	.	.	ID=COSV57957185;OCCURENCE=1(prostate),1(endometrium)	EZHIP	278	0	378	46	0.108490566037736	TRUE	TRUE
ENSG00000050030.15	.	BCM	GRCh38.p13	chrX	74739466	74739466	+	G	G	T	Missense_Mutation	SNP	ENST00000055682.12	exon4	c.C4490A	p.T1497K	exonic	ENSG00000050030.15	.	nonsynonymous SNV	ENSG00000050030.15:ENST00000055682.12:exon4:c.C4490A:p.T1497K	Xq13.3	C3N-03439	.	.	.	.	.	.	.	.	.	6.18	D	D	B	B	N	D	.	T	N	0.477	T	T	D	0.107	0.323	0.271	0.306	T	T	T	T	D	T	2.380	22.000	0.983	D	.	.	.	.	.	0.004	.	.	.	.	.	5.500	3.690	3.634	1.175	0.676	1.000	1.000	0.990	103	.	.	.	.	NEXMIF	146	0	251	28	0.100358422939068	TRUE	TRUE
ENSG00000158290.18	.	BCM	GRCh38.p13	chrX	120543788	120543788	+	C	C	A	Missense_Mutation	SNP	ENST00000404115.7	exon10	c.G1249T	p.V417F	exonic	ENSG00000158290.18	.	nonsynonymous SNV	ENSG00000158290.18:ENST00000404115.7:exon10:c.G1249T:p.V417F	Xq24	C3N-03439	.	.	.	.	.	.	.	.	.	19.19	D	D	D	D	D	D	M	D	D	0.854	D	D	D	0.902	0.776	0.985	1.786	D	D	D	D	D	D	3.712	25.500	0.995	D	.	.	.	.	.	1.000	.	.	.	.	.	6.030	6.030	7.816	1.026	0.599	1.000	1.000	0.998	937	Cullin,_N-terminal	.	.	.	CUL4B	230	0	421	34	0.0747252747252747	TRUE	TRUE
ENSG00000268089.3	.	BCM	GRCh38.p13	chrX	152650531	152650531	+	G	G	T	Missense_Mutation	SNP	ENST00000598523.3	exon7	c.G852T	p.W284C	exonic	ENSG00000268089.3	.	nonsynonymous SNV	ENSG00000268089.3:ENST00000598523.3:exon7:c.G852T:p.W284C	Xq28	C3N-03439	.	.	.	.	.	.	.	.	.	11.12	.	D	.	.	D	D	.	D	.	0.974	D	D	D	0.825	0.842	0.788	.	T	.	D	D	D	.	4.318	29.700	0.991	D	.	.	.	.	.	1.000	.	.	.	.	.	6.080	6.080	10.003	1.176	0.676	1.000	0.995	0.972	628	.	.	.	.	GABRQ	169	0	278	25	0.0825082508250825	TRUE	TRUE
ENSG00000126895.15	.	BCM	GRCh38.p13	chrX	153906245	153906245	+	C	C	T	Missense_Mutation	SNP	ENST00000646375.1	exon3	c.C739T	p.R247C	exonic	ENSG00000126895.15	.	nonsynonymous SNV	ENSG00000126895.15:ENST00000646375.1:exon3:c.C739T:p.R247C	Xq28	C3N-03439	1.147e-05	0	0	0	0	2.103e-05	0	0	rs782715616	1.19	T	T	B	B	N	N	L	T	N	0.119	T	T	D	0.048	.	0.977	0.686	T	T	T	T	T	T	0.791	9.302	0.946	N	.	.	.	.	.	0.993	.	.	.	.	.	3.990	-0.546	-0.039	-0.334	0.539	0.000	0.010	0.006	180	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV61686551;OCCURENCE=1(breast),1(large_intestine)	AVPR2	203	0	312	33	0.0956521739130435	TRUE	TRUE
ENSG00000155961.5	.	BCM	GRCh38.p13	chrX	155260982	155260982	+	G	G	A	Nonsense_Mutation	SNP	ENST00000369454.4	exon2	c.C463T	p.R155X	exonic	ENSG00000155961.5	.	stopgain	ENSG00000155961.5:ENST00000369454.4:exon2:c.C463T:p.R155X	Xq28	C3N-03439	.	.	.	.	.	.	.	.	.	5.5	.	.	.	.	D	D	.	.	.	0.819	.	.	.	.	.	.	.	.	.	D	D	.	.	7.072	37	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.170	5.170	9.515	1.176	0.676	1.000	1.000	1.000	.	Small_GTP-binding_protein_domain	.	.	ID=COSV65624331;OCCURENCE=1(endometrium)	RAB39B	147	0	191	37	0.162280701754386	TRUE	TRUE
ENSG00000060718.22	.	BCM	GRCh38.p13	chr1	102984193	102984193	+	T	T	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000060718.22	ENST00000370096.9:exon31:c.2503-2A>C	.	.	1p21.1	C3N-03439	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.889	33	0.995	D	.	1.076	16.524	0.909	14.154	0.998	0.061	0.063	0.063	0.057	0.967	5.200	5.200	7.271	1.138	0.665	1.000	0.532	0.468	856	.	.	.	.	COL11A1	118	0	277	25	0.0827814569536424	TRUE	TRUE
ENSG00000068654.16	.	BCM	GRCh38.p13	chr2	86033788	86033788	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000068654.16	ENST00000263857.11:exon28:c.4035-1G>T	.	.	2p11.2	C3N-03439	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.137	33	0.993	D	.	0.954	12.529	0.758	8.987	1.000	0.295	0.304	0.138	0.118	0.962	5.380	5.380	5.433	1.026	0.599	0.997	0.135	0.631	680	.	.	.	.	POLR1A	82	0	146	12	0.0759493670886076	TRUE	TRUE
ENSG00000169991.11	.	BCM	GRCh38.p13	chr1	18910350	18910350	+	G	G	A	Silent	SNP	ENST00000455833.7	exon8	c.C1440T	p.S480S	exonic	ENSG00000169991.11	.	synonymous SNV	ENSG00000169991.11:ENST00000455833.7:exon8:c.C1440T:p.S480S	1p36.13	C3N-03439	0.0096	0.0018	0.0025	0.0118	0.0080	0.0050	0.0070	0.0329	rs61752549	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IFFO2	201	0	342	36	0.0952380952380952	TRUE	NA
ENSG00000198216.12	.	BCM	GRCh38.p13	chr1	181757952	181757952	+	G	G	A	Silent	SNP	ENST00000367573.7	exon31	c.G4335A	p.A1445A	exonic	ENSG00000198216.12	.	synonymous SNV	ENSG00000198216.12:ENST00000367573.7:exon31:c.G4335A:p.A1445A	1q25.3	C3N-03439	7.489e-05	0	0.0004	0.0001	0	4.509e-05	0	0	rs779279181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA1E	148	0	215	30	0.122448979591837	TRUE	NA
ENSG00000163395.17	.	BCM	GRCh38.p13	chr1	201217363	201217363	+	T	T	A	Silent	SNP	ENST00000295591.12	exon18	c.T2301A	p.P767P	exonic	ENSG00000163395.17	.	synonymous SNV	ENSG00000163395.17:ENST00000295591.12:exon18:c.T2301A:p.P767P	1q32.1	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGFN1	291	1	438	39	0.0817610062893082	TRUE	TRUE
ENSG00000162951.11	.	BCM	GRCh38.p13	chr2	80303205	80303205	+	G	G	A	Silent	SNP	ENST00000295057.4	exon2	c.C615T	p.F205F	exonic	ENSG00000162951.11	.	synonymous SNV	ENSG00000162951.11:ENST00000295057.4:exon2:c.C615T:p.F205F	2p12	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54437951;OCCURENCE=1(oesophagus)	LRRTM1	238	0	393	24	0.0575539568345324	TRUE	TRUE
ENSG00000164344.16	.	BCM	GRCh38.p13	chr4	186254726	186254726	+	C	C	T	Silent	SNP	ENST00000264690.11	exon12	c.C1452T	p.I484I	exonic	ENSG00000164344.16	.	synonymous SNV	ENSG00000164344.16:ENST00000264690.11:exon12:c.C1452T:p.I484I	4q35.2	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52994761;OCCURENCE=1(skin)	KLKB1	169	1	279	33	0.105769230769231	TRUE	TRUE
ENSG00000204963.6	.	BCM	GRCh38.p13	chr5	140836054	140836054	+	C	C	T	Silent	SNP	ENST00000525929.2	exon1	c.C1671T	p.D557D	exonic	ENSG00000204963.6	.	synonymous SNV	ENSG00000204963.6:ENST00000525929.2:exon1:c.C1671T:p.D557D	5q31.3	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65343247;OCCURENCE=1(liver),2(large_intestine),1(stomach)	PCDHA7	526	0	596	121	0.168758716875872	NA	TRUE
ENSG00000158553.4	.	BCM	GRCh38.p13	chr6	27312042	27312042	+	G	G	A	Silent	SNP	ENST00000444565.1	exon1	c.C129T	p.F43F	exonic	ENSG00000158553.4	.	synonymous SNV	ENSG00000158553.4:ENST00000444565.1:exon1:c.C129T:p.F43F	6p22.1	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	POM121L2	42	0	53	5	0.0862068965517241	TRUE	TRUE
ENSG00000130711.4	.	BCM	GRCh38.p13	chr9	130668250	130668250	+	C	C	T	Silent	SNP	ENST00000253008.3	exon3	c.C507T	p.N169N	exonic	ENSG00000130711.4	.	synonymous SNV	ENSG00000130711.4:ENST00000253008.3:exon3:c.C507T:p.N169N	9q34.12	C3N-03439	8.262e-05	9.643e-05	0	0	0	1.505e-05	0	0.0005	rs369430134	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53391936;OCCURENCE=1(oesophagus),1(haematopoietic_and_lymphoid_tissue),1(endometrium)	PRDM12	268	0	335	34	0.0921409214092141	TRUE	TRUE
ENSG00000015171.19	.	BCM	GRCh38.p13	chr10	246841	246841	+	T	T	C	Silent	SNP	ENST00000381591.5	exon11	c.T1026C	p.G342G	exonic	ENSG00000015171.19	.	synonymous SNV	ENSG00000015171.19:ENST00000381591.5:exon11:c.T1026C:p.G342G	10p15.3	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZMYND11	470	0	725	87	0.107142857142857	NA	TRUE
ENSG00000006071.15	.	BCM	GRCh38.p13	chr11	17461670	17461670	+	G	G	A	Silent	SNP	ENST00000389817.8	exon5	c.C735T	p.I245I	exonic	ENSG00000006071.15	.	synonymous SNV	ENSG00000006071.15:ENST00000389817.8:exon5:c.C735T:p.I245I	11p15.1	C3N-03439	0.0002	0	0	0	0	2.997e-05	0	0.0013	rs535141079	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56857654;OCCURENCE=1(NS),2(skin)	ABCC8	504	0	750	60	0.0740740740740741	TRUE	TRUE
ENSG00000184613.10	.	BCM	GRCh38.p13	chr12	44523309	44523309	+	G	G	A	Silent	SNP	ENST00000429094.6	exon17	c.C1980T	p.C660C	exonic	ENSG00000184613.10	.	synonymous SNV	ENSG00000184613.10:ENST00000429094.6:exon17:c.C1980T:p.C660C	12q12	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NELL2	233	0	361	39	0.0975	TRUE	TRUE
ENSG00000211827.1	.	BCM	GRCh38.p13	chr14	22456709	22456709	+	T	T	C	Unknown	SNP	NA	NA	NA	NA	exonic	ENSG00000211827.1	.	unknown	UNKNOWN	14q11.2	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRDJ2	321	0	346	40	0.103626943005181	TRUE	NA
ENSG00000103365.15	.	BCM	GRCh38.p13	chr16	23486039	23486039	+	G	G	T	Silent	SNP	ENST00000309859.8	exon8	c.C774A	p.A258A	exonic	ENSG00000103365.15	.	synonymous SNV	ENSG00000103365.15:ENST00000309859.8:exon8:c.C774A:p.A258A	16p12.2	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GGA2	193	0	310	37	0.106628242074928	TRUE	TRUE
ENSG00000005381.8	.	BCM	GRCh38.p13	chr17	58271858	58271858	+	C	C	T	Silent	SNP	ENST00000225275.4	exon11	c.G1827A	p.P609P	exonic	ENSG00000005381.8	.	synonymous SNV	ENSG00000005381.8:ENST00000225275.4:exon11:c.G1827A:p.P609P	17q22	C3N-03439	2.477e-05	0	0	0	0	4.512e-05	0	0	rs781536912	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51859729;OCCURENCE=2(large_intestine),1(endometrium)	MPO	236	1	336	37	0.0991957104557641	TRUE	TRUE
ENSG00000183036.11	.	BCM	GRCh38.p13	chr21	39929051	39929051	+	G	G	A	Silent	SNP	ENST00000328619.10	exon3	c.G129A	p.A43A	exonic	ENSG00000183036.11	.	synonymous SNV	ENSG00000183036.11:ENST00000328619.10:exon3:c.G129A:p.A43A	21q22.2	C3N-03439	8.239e-06	0	0	0	0	1.499e-05	0	0	rs769109934	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60786391;OCCURENCE=2(large_intestine),1(haematopoietic_and_lymphoid_tissue),1(pancreas)	PCP4	126	0	157	11	0.0654761904761905	TRUE	TRUE
ENSG00000100359.21	.	BCM	GRCh38.p13	chr22	40406142	40406142	+	G	G	C	Silent	SNP	ENST00000248929.14	exon9	c.G879C	p.L293L	exonic	ENSG00000100359.21	.	synonymous SNV	ENSG00000100359.21:ENST00000248929.14:exon9:c.G879C:p.L293L	22q13.1	C3N-03439	.	.	.	.	.	.	.	.	rs917899331	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SGSM3	219	0	297	25	0.077639751552795	TRUE	NA
ENSG00000143924.19	.	BCM	GRCh38.p13	chr2	42333828	42333828	+	C	C	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000143924.19;ENSG00000115944.15	dist=1280;dist=15510	.	.	2p21	C3N-03439	.	.	.	.	.	.	.	.	.	0.11	T	T	.	.	.	.	.	.	N	.	T	T	.	0.030	0.233	0.088	.	.	.	T	T	T	T	0.139	2.468	0.579	N	N	-0.566	1.050	-0.772	0.797	0.991	0.372	0.380	0.487	0.492	.	2.090	1.210	0.706	0.721	0.469	0.002	0.007	0.010	917	.	.	.	.	EML4	89	0	167	14	0.0773480662983425	TRUE	TRUE
ENSG00000184220.12	.	BCM	GRCh38.p13	chr3	99830603	99830603	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000184220.12	.	.	.	3q12.1	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CMSS1	117	0	162	16	0.0898876404494382	TRUE	NA
ENSG00000174963.17	.	BCM	GRCh38.p13	chr3	147405408	147405408	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000174963.17	.	.	.	3q24	C3N-03439	.	.	.	.	.	.	.	.	.	2.13	D	D	.	.	.	.	.	T	N	0.091	T	T	T	0.065	0.352	0.156	.	.	.	T	T	T	T	-0.261	0.377	0.937	N	N	-0.803	0.650	-0.982	0.512	0.998	0.447	0.563	0.504	0.530	.	3.890	-2.090	-1.664	0.074	0.599	0.000	0.000	0.001	945	.	.	.	.	ZIC4	169	0	225	19	0.0778688524590164	TRUE	NA
ENSG00000255622.3	.	BCM	GRCh38.p13	chr5	141156188	141156188	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000255622.3	.	.	.	5q31.3	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHB17P	174	0	236	27	0.102661596958175	TRUE	NA
ENSG00000136270.14	.	BCM	GRCh38.p13	chr7	45111658	45111658	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000136270.14	ENST00000258770.8:c.-2421C>T	.	.	7p13	C3N-03439	.	.	.	.	.	.	.	.	rs1013396252	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99345789;OCCURENCE=1(stomach)	TBRG4	157	0	287	29	0.0917721518987342	TRUE	NA
ENSG00000132549.18	.	BCM	GRCh38.p13	chr8	99121462	99121462	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000132549.18	.	.	.	8q22.2	C3N-03439	.	.	.	.	.	.	.	.	.	3.16	D	T	B	B	.	N	.	D	N	0.162	T	T	D	0.131	0.582	0.372	.	.	.	T	T	T	T	0.168	2.765	0.667	N	N	-1.099	0.308	-1.120	0.356	0.000	0.372	0.546	0.547	0.492	.	4.290	-1.010	0.235	-0.773	-0.128	0.000	0.026	0.320	819	.	.	.	.	VPS13B	93	0	134	15	0.100671140939597	TRUE	NA
ENSG00000122882.11	.	BCM	GRCh38.p13	chr10	73141448	73141448	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000122882.11	.	.	.	10q22.2	C3N-03439	.	.	.	.	.	.	.	.	.	1.14	T	D	.	.	.	N	.	T	N	0.058	T	T	T	0.024	0.384	0.173	0.077	.	.	T	T	T	T	-0.135	0.703	0.785	N	N	-1.288	0.171	-1.386	0.159	0.000	0.000	0.637	0.514	0.714	.	0.109	0.109	-0.682	-1.623	-1.783	0.002	0.001	0.001	902	.	.	.	.	ECD	31	0	41	4	0.0888888888888889	TRUE	TRUE
ENSG00000166575.17	.	BCM	GRCh38.p13	chr11	87328513	87328513	+	G	G	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000166575.17	ENST00000305494.6:c.*7180G>T	.	.	11q14.2	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM135	233	0	377	33	0.0804878048780488	TRUE	NA
ENSG00000255093.2	.	BCM	GRCh38.p13	chr11	111453580	111453580	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000255093.2	.	.	.	11q23.1	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AP002008.2	73	0	102	13	0.11304347826087	TRUE	NA
ENSG00000256269.10	.	BCM	GRCh38.p13	chr11	119088753	119088753	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000256269.10	.	.	.	11q23.3	C3N-03439	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HMBS	415	0	613	48	0.0726172465960666	TRUE	NA
ENSG00000170325.14	.	BCM	GRCh38.p13	chr11	129914629	129914629	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000170325.14	.	.	.	11q24.3	C3N-03439	1.024e-05	0.0001	0	0	0	0	0	0	rs760426995	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRDM10	324	0	438	32	0.0680851063829787	TRUE	NA
ENSG00000258380.1	.	BCM	GRCh38.p13	chr14	89401610	89401610	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000258380.1	.	.	.	14q32.11	C3N-03439	.	.	.	.	.	.	.	.	.	0.12	T	T	.	.	.	N	.	.	N	.	T	T	.	0.025	0.206	0.043	.	.	.	T	T	T	T	-0.754	0.033	0.659	N	N	-1.218	0.214	-1.427	0.138	1.000	0.372	0.546	0.634	0.714	.	3.390	-3.740	-1.782	-2.061	-5.304	0.000	0.000	0.000	768	.	.	.	.	AL356805.1	220	0	368	40	0.0980392156862745	TRUE	TRUE
ENSG00000259495.3	.	BCM	GRCh38.p13	chr15	80380137	80380137	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000259495.3	.	.	.	15q25.1	C3N-03439	0.0008	0	0	0	.	0	0	0.0012	rs755386647	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC016705.2	162	0	302	24	0.0736196319018405	TRUE	NA
ENSG00000174403.16	.	BCM	GRCh38.p13	chr20	62546573	62546573	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000174403.16	.	.	.	20q13.33	C3N-03439	0.0002	0	0	0.0017	0	0	0	0.0006	rs576312365	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR1-1HG-AS1	226	0	317	34	0.0968660968660969	TRUE	NA
ENSG00000134243.12	.	BCM	GRCh38.p13	chr1	109345867	109345867	+	C	C	T	Missense_Mutation	SNP	ENST00000256637.8	exon8	c.G847A	p.A283T	exonic	ENSG00000134243.12	.	nonsynonymous SNV	ENSG00000134243.12:ENST00000256637.8:exon8:c.G847A:p.A283T	1p13.3	C3N-03006	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.105	T	T	T	0.055	0.447	0.123	0.239	T	T	T	T	T	T	1.685	16.930	0.981	D	N	-0.540	1.099	-0.283	1.599	0.993	0.732	0.588	0.744	0.580	.	5.820	4.900	1.391	0.124	0.549	0.807	0.992	0.998	649	Sortilin,_N-terminal;VPS10	.	.	.	SORT1	112	0	159	9	0.0535714285714286	NA	TRUE
ENSG00000271425.9	.	BCM	GRCh38.p13	chr1	146069543	146069543	+	C	C	G	Missense_Mutation	SNP	ENST00000583866.9	exon86	c.G10810C	p.E3604Q	exonic	ENSG00000271425.9	.	nonsynonymous SNV	ENSG00000271425.9:ENST00000583866.9:exon86:c.G10810C:p.E3604Q	1q21.1	C3N-03006	.	.	.	.	.	.	.	.	.	2.3	.	D	.	.	.	.	.	.	.	0.072	.	.	.	.	.	.	.	.	.	.	.	.	D	0.903	10.460	.	.	N	.	.	.	.	.	.	.	.	.	.	.	.	-2.685	-2.422	-2.799	0.000	0.000	0.000	958	Neuroblastoma_breakpoint_family_(NBPF)_domain	.	.	.	NBPF10	135	0	233	17	0.068	NA	TRUE
ENSG00000152092.16	.	BCM	GRCh38.p13	chr1	176894765	176894765	+	A	A	C	Missense_Mutation	SNP	ENST00000361833.7	exon17	c.T2737G	p.Y913D	exonic	ENSG00000152092.16	.	nonsynonymous SNV	ENSG00000152092.16:ENST00000361833.7:exon17:c.T2737G:p.Y913D	1q25.2	C3N-03006	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	.	T	D	0.874	T	T	D	0.517	0.325	0.446	0.764	D	T	D	D	D	D	3.619	25.100	0.990	D	D	0.653	6.515	0.616	6.434	1.000	0.615	0.590	0.659	0.564	.	5.260	5.260	8.557	1.312	0.754	1.000	0.958	0.318	686	Membrane_attack_complex_component/perforin_(MACPF)_domain	.	.	.	ASTN1	408	0	493	32	0.060952380952381	TRUE	TRUE
ENSG00000240382.3	.	BCM	GRCh38.p13	chr2	89117427	89117427	+	G	G	A	Missense_Mutation	SNP	ENST00000490686.1	exon2	c.C266T	p.S89F	exonic	ENSG00000240382.3	.	nonsynonymous SNV	ENSG00000240382.3:ENST00000490686.1:exon2:c.C266T:p.S89F	2p11.2	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGKV1-17	391	1	520	48	0.0845070422535211	NA	TRUE
ENSG00000135973.3	.	BCM	GRCh38.p13	chr2	105242150	105242150	+	G	G	A	Missense_Mutation	SNP	ENST00000258456.3	exon1	c.G292A	p.V98M	exonic	ENSG00000135973.3	.	nonsynonymous SNV	ENSG00000135973.3:ENST00000258456.3:exon1:c.G292A:p.V98M	2q12.1	C3N-03006	.	.	.	.	.	.	.	.	.	3.20	T	T	D	P	N	N	L	T	N	0.261	T	T	T	0.123	0.404	0.252	1.456	T	T	T	T	D	D	2.632	22.700	0.998	N	N	0.030	2.620	-0.049	2.198	0.998	0.516	0.610	0.573	0.542	.	5.440	4.550	2.448	1.101	0.590	0.225	0.921	0.957	957	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV99307239;OCCURENCE=1(lung)	GPR45	534	0	591	66	0.100456621004566	TRUE	NA
ENSG00000176771.17	.	BCM	GRCh38.p13	chr2	132781957	132781957	+	C	C	T	Missense_Mutation	SNP	ENST00000409261.6	exon14	c.G4854A	p.M1618I	exonic	ENSG00000176771.17	.	nonsynonymous SNV	ENSG00000176771.17:ENST00000409261.6:exon14:c.G4854A:p.M1618I	2q21.2	C3N-03006	.	.	.	.	.	.	.	.	.	7.20	D	T	P	B	U	D	M	T	N	0.643	T	T	T	0.127	0.328	0.134	0.059	T	T	T	T	D	D	2.927	23.300	0.987	D	D	0.127	2.994	0.230	3.333	0.124	0.554	0.588	0.618	0.564	.	5.140	5.140	4.216	1.026	0.547	1.000	0.993	0.863	976	Nck-associated_protein_5,_C-terminal	.	.	.	NCKAP5	69	0	114	7	0.0578512396694215	TRUE	TRUE
ENSG00000128709.13	.	BCM	GRCh38.p13	chr2	176123430	176123430	+	C	C	T	Missense_Mutation	SNP	ENST00000249499.8	exon1	c.C662T	p.T221M	exonic	ENSG00000128709.13	.	nonsynonymous SNV	ENSG00000128709.13:ENST00000249499.8:exon1:c.C662T:p.T221M	2q31.1	C3N-03006	.	.	.	.	.	.	.	.	.	3.20	T	T	P	B	N	N	N	D	N	0.202	T	T	D	0.233	0.306	0.905	0.729	T	T	T	T	T	T	1.876	18.300	0.952	D	N	-0.423	1.334	-0.372	1.424	1.000	0.652	0.590	0.616	0.710	.	3.880	2.910	1.802	0.035	0.524	0.843	0.013	0.077	711	.	.	.	ID=COSV50890714;OCCURENCE=1(large_intestine)	HOXD9	96	0	159	13	0.0755813953488372	TRUE	TRUE
ENSG00000163694.15	.	BCM	GRCh38.p13	chr4	40437971	40437971	+	C	C	T	Missense_Mutation	SNP	ENST00000295971.12	exon4	c.G923A	p.G308D	exonic	ENSG00000163694.15	.	nonsynonymous SNV	ENSG00000163694.15:ENST00000295971.12:exon4:c.G923A:p.G308D	4p14	C3N-03006	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	L	D	D	0.847	D	D	D	0.824	0.719	0.448	2.584	D	T	D	D	D	D	3.771	25.700	0.997	D	D	0.732	7.597	0.736	8.490	1.000	0.646	0.702	0.696	0.542	.	5.580	5.580	7.512	0.962	0.524	1.000	1.000	0.992	803	Putative_RNA-binding_protein_47,_RNA_recognition_motif_3;RNA_recognition_motif_domain	.	.	.	RBM47	241	0	262	16	0.0575539568345324	TRUE	TRUE
ENSG00000138688.15	.	BCM	GRCh38.p13	chr4	122239632	122239632	+	G	G	A	Missense_Mutation	SNP	ENST00000264501.8	exon29	c.G3950A	p.R1317H	exonic	ENSG00000138688.15	.	nonsynonymous SNV	ENSG00000138688.15:ENST00000264501.8:exon29:c.G3950A:p.R1317H	4q27	C3N-03006	1.656e-05	0.0001	0	0	0	1.499e-05	0	0	rs372137155	9.20	D	D	D	D	U	D	L	T	N	0.435	T	T	T	0.325	0.267	0.628	0.153	D	T	T	T	T	D	3.664	25.300	0.999	D	D	0.755	7.955	0.813	10.525	1.000	0.707	0.709	0.651	0.714	.	5.980	5.980	9.519	1.176	0.676	1.000	0.919	0.861	842	.	.	.	ID=COSV52662055;OCCURENCE=2(endometrium)	KIAA1109	108	0	102	7	0.0642201834862385	TRUE	TRUE
ENSG00000112769.20	.	BCM	GRCh38.p13	chr6	112187500	112187500	+	C	C	T	Missense_Mutation	SNP	ENST00000230538.12	exon8	c.G916A	p.A306T	exonic	ENSG00000112769.20	.	nonsynonymous SNV	ENSG00000112769.20:ENST00000230538.12:exon8:c.G916A:p.A306T	6q21	C3N-03006	1.648e-05	0	0	0	0	0	0	0.0001	rs782180044	5.17	T	D	.	.	D	D	.	T	N	0.445	T	T	T	0.220	0.714	0.353	0.170	T	T	T	T	T	T	1.917	18.620	0.997	D	D	0.326	3.917	0.375	4.187	1.000	0.672	0.590	0.602	0.711	.	5.760	5.760	4.531	1.026	0.599	0.999	0.004	0.018	741	Laminin_alpha,_domain_I	.	.	.	LAMA4	585	3	713	41	0.0543766578249337	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971187	21971187	+	G	G	A	Nonsense_Mutation	SNP	ENST00000304494.9	exon2	c.C172T	p.R58X	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon2:c.C172T:p.R58X	9p21.3	C3N-03006	.	.	.	.	.	.	.	.	rs121913387	4.15	D	T	.	.	N	D	.	T	D	0.185	T	T	.	0.220	.	0.879	.	.	T	T	T	D	T	5.550	34	0.997	N	N	-0.315	1.578	-0.449	1.286	1.000	0.677	0.383	0.608	0.601	.	5.790	2.710	-0.135	1.176	0.676	0.000	0.031	0.057	900	.	.	.	ID=COSV58682666;OCCURENCE=1(salivary_gland),3(breast),9(penis),1(peritoneum),5(liver),18(oesophagus),1(cervix),8(vulva),6(ovary),17(NS),4(haematopoietic_and_lymphoid_tissue),4(stomach),4(urinary_tract),2(soft_tissue),18(pancreas),41(skin),18(lung),42(upper_aerodigestive_tract),1(thymus),1(endometrium)	CDKN2A	529	0	536	70	0.115511551155116	NA	TRUE
ENSG00000148291.10	.	BCM	GRCh38.p13	chr9	133360045	133360045	+	C	C	T	Missense_Mutation	SNP	ENST00000371964.5	exon4	c.C433T	p.R145C	exonic	ENSG00000148291.10	.	nonsynonymous SNV	ENSG00000148291.10:ENST00000371964.5:exon4:c.C433T:p.R145C	9q34.2	C3N-03006	.	.	.	.	.	.	.	.	.	0.15	T	T	.	.	N	N	.	T	N	0.211	T	T	T	0.041	0.445	0.146	0.081	T	.	T	T	T	.	1.009	11.740	0.976	N	N	-1.434	0.104	-1.480	0.115	1.000	0.672	0.698	0.644	0.711	.	5.280	-0.581	-0.191	-0.799	-0.165	0.000	0.000	0.000	908	.	.	.	ID=COSV64332277;OCCURENCE=1(cervix),1(stomach),2(urinary_tract),3(lung),1(upper_aerodigestive_tract)	SURF2	85	0	94	8	0.0784313725490196	TRUE	TRUE
ENSG00000047056.16	.	BCM	GRCh38.p13	chr10	1124959	1124959	+	C	C	T	Nonsense_Mutation	SNP	ENST00000263150.9	exon13	c.C1288T	p.R430X	exonic	ENSG00000047056.16	.	stopgain	ENSG00000047056.16:ENST00000263150.9:exon13:c.C1288T:p.R430X	10p15.3	C3N-03006	8.244e-06	0	0	0	0	1.5e-05	0	0	rs554547796	5.6	.	.	.	.	D	A	.	.	.	0.349	.	.	.	.	.	.	.	.	.	D	D	.	.	8.261	42	0.998	D	N	0.711	7.270	0.571	5.878	1.000	0.706	0.654	0.710	0.714	.	5.410	4.480	3.653	0.980	0.549	1.000	0.999	0.992	676	WD40-repeat-containing_domain	.	.	.	WDR37	206	0	202	32	0.136752136752137	TRUE	NA
ENSG00000183621.15	.	BCM	GRCh38.p13	chr10	30848925	30848925	+	C	C	T	Missense_Mutation	SNP	ENST00000442986.5	exon7	c.G1480A	p.V494M	exonic	ENSG00000183621.15	.	nonsynonymous SNV	ENSG00000183621.15:ENST00000442986.5:exon7:c.G1480A:p.V494M	10p11.23	C3N-03006	0.0002	0	0	0	0	0.0003	0	6.056e-05	rs145592963	2.20	T	D	D	P	N	N	L	T	N	0.120	T	T	T	0.131	.	0.178	0.091	T	T	T	T	T	T	0.702	8.475	0.960	N	N	-0.782	0.682	-0.758	0.817	0.234	0.615	0.634	0.602	0.636	.	5.590	4.690	0.367	-0.713	-0.827	0.000	0.004	0.948	964	.	.	.	ID=COSV59197771;OCCURENCE=2(large_intestine)	ZNF438	237	0	296	43	0.126843657817109	TRUE	TRUE
ENSG00000198298.13	.	BCM	GRCh38.p13	chr10	43617020	43617020	+	A	A	G	Missense_Mutation	SNP	ENST00000361807.8	exon5	c.A977G	p.Y326C	exonic	ENSG00000198298.13	.	nonsynonymous SNV	ENSG00000198298.13:ENST00000361807.8:exon5:c.A977G:p.Y326C	10q11.21	C3N-03006	.	.	.	.	.	.	.	.	.	7.19	D	D	D	D	.	N	M	T	D	0.142	T	T	T	0.070	0.537	0.511	0.640	T	T	T	T	D	T	2.942	23.300	0.930	N	N	-0.085	2.224	-0.353	1.460	0.015	0.615	0.634	0.659	0.568	.	2.190	1.030	-0.568	0.911	0.561	0.000	0.998	0.395	529	Zinc_finger_C2H2-type	.	.	.	ZNF485	203	0	314	41	0.115492957746479	TRUE	NA
ENSG00000167792.13	.	BCM	GRCh38.p13	chr11	67611207	67611207	+	G	G	C	Missense_Mutation	SNP	ENST00000322776.11	exon6	c.G913C	p.G305R	exonic	ENSG00000167792.13	.	nonsynonymous SNV	ENSG00000167792.13:ENST00000322776.11:exon6:c.G913C:p.G305R	11q13.2	C3N-03006	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.955	D	D	D	0.882	0.823	0.952	0.911	D	D	D	D	D	D	5.547	34	0.999	D	D	0.980	13.291	0.885	13.121	1.000	0.732	0.698	0.744	0.714	.	5.080	5.080	9.608	1.176	0.618	1.000	1.000	0.973	774	Soluble_ligand_binding_domain	.	.	.	NDUFV1	185	0	203	17	0.0772727272727273	TRUE	TRUE
ENSG00000175581.14	.	BCM	GRCh38.p13	chr11	73859914	73859914	+	A	A	G	Missense_Mutation	SNP	ENST00000310614.12	exon6	c.A379G	p.M127V	exonic	ENSG00000175581.14	.	nonsynonymous SNV	ENSG00000175581.14:ENST00000310614.12:exon6:c.A379G:p.M127V	11q13.4	C3N-03006	.	.	.	.	.	.	.	.	.	5.20	D	T	B	B	D	D	M	T	N	0.378	T	T	T	0.037	0.586	0.311	0.254	T	T	T	T	T	D	1.425	15.250	0.721	N	N	-0.578	1.028	-0.524	1.164	0.967	0.732	0.744	0.644	0.728	.	5.650	1.760	0.750	1.312	0.756	0.308	0.968	0.820	220	Ribosomal_protein_S10_domain	.	.	.	MRPL48	131	0	126	12	0.0869565217391304	TRUE	TRUE
ENSG00000110172.12	.	BCM	GRCh38.p13	chr11	90203424	90203424	+	T	T	C	Missense_Mutation	SNP	ENST00000320585.11	exon9	c.A673G	p.K225E	exonic	ENSG00000110172.12	.	nonsynonymous SNV	ENSG00000110172.12:ENST00000320585.11:exon9:c.A673G:p.K225E	11q14.3	C3N-03006	2.48e-05	0	0	0	0	4.51e-05	0	0	rs754005973	3.19	D	T	B	B	N	D	N	T	N	0.289	T	T	T	0.045	0.442	0.244	0.179	T	T	T	T	T	.	2.346	21.800	0.990	D	N	-0.406	1.371	-0.205	1.775	0.778	0.651	0.654	0.609	0.684	.	6.070	3.570	4.202	0.192	0.660	1.000	0.995	0.985	916	.	.	.	ID=COSV57706216;OCCURENCE=1(endometrium)	CHORDC1	25	0	41	6	0.127659574468085	TRUE	TRUE
ENSG00000171014.2	.	BCM	GRCh38.p13	chr11	123940385	123940385	+	G	G	A	Missense_Mutation	SNP	ENST00000307033.2	exon1	c.G769A	p.V257I	exonic	ENSG00000171014.2	.	nonsynonymous SNV	ENSG00000171014.2:ENST00000307033.2:exon1:c.G769A:p.V257I	11q24.1	C3N-03006	6.592e-05	0	8.637e-05	0	0	0.0001	0	0	rs776996786	0.20	T	T	B	B	N	N	N	T	N	0.046	T	T	T	0.041	0.280	0.124	0.015	T	T	T	T	T	T	0.338	4.732	0.818	N	N	-1.024	0.380	-0.812	0.741	0.000	0.487	0.574	0.574	0.564	.	4.960	2.630	0.634	0.286	-0.078	0.000	0.951	0.954	883	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58309069;OCCURENCE=1(prostate)	OR4D5	210	0	212	14	0.0619469026548673	TRUE	TRUE
ENSG00000171681.12	.	BCM	GRCh38.p13	chr12	14423982	14423982	+	C	C	-	Frame_Shift_Del	NA	ENST00000261168.8	exon2	c.67delC	p.R23Vfs*15	exonic	ENSG00000171681.12	.	frameshift deletion	ENSG00000171681.12:ENST00000261168.8:exon2:c.67delC:p.R23Vfs*15	12p13.1	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATF7IP	106	0	134	11	0.0758620689655172	NA	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-03006	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	229	0	292	28	0.0875	TRUE	TRUE
ENSG00000139292.13	.	BCM	GRCh38.p13	chr12	71584163	71584163	+	G	G	A	Missense_Mutation	SNP	ENST00000266674.10	exon18	c.G2153A	p.G718E	exonic	ENSG00000139292.13	.	nonsynonymous SNV	ENSG00000139292.13:ENST00000266674.10:exon18:c.G2153A:p.G718E	12q21.1	C3N-03006	.	.	.	.	.	.	.	.	.	10.19	D	D	D	D	N	D	M	T	D	0.601	T	T	T	0.244	0.458	0.844	0.247	T	T	T	T	D	D	3.710	25.400	0.998	D	.	0.627	6.215	0.599	6.217	1.000	0.549	0.627	0.547	0.542	.	5.850	4.960	6.154	1.176	0.676	1.000	0.626	0.967	881	GPCR,_rhodopsin-like,_7TM	.	.	.	LGR5	217	0	319	17	0.0505952380952381	TRUE	TRUE
ENSG00000136003.15	.	BCM	GRCh38.p13	chr12	108568851	108568851	+	A	A	-	Frame_Shift_Del	NA	ENST00000311893.13	exon5	c.439delA	p.K147Rfs*9	exonic	ENSG00000136003.15	.	frameshift deletion	ENSG00000136003.15:ENST00000311893.13:exon5:c.439delA:p.K147Rfs*9	12q23.3	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ISCU	351	0	476	27	0.0536779324055666	NA	TRUE
ENSG00000089154.11	.	BCM	GRCh38.p13	chr12	120140880	120140880	+	C	C	A	Missense_Mutation	SNP	ENST00000300648.7	exon45	c.G5973T	p.M1991I	exonic	ENSG00000089154.11	.	nonsynonymous SNV	ENSG00000089154.11:ENST00000300648.7:exon45:c.G5973T:p.M1991I	12q24.23	C3N-03006	.	.	.	.	.	.	.	.	.	9.15	T	T	.	.	D	D	.	T	N	0.913	T	T	D	0.302	0.430	0.898	0.754	D	.	D	D	D	.	3.369	24.300	0.990	D	D	-0.098	2.182	0.116	2.802	1.000	0.707	0.702	0.702	0.714	.	5.010	5.010	7.266	1.026	0.599	1.000	1.000	0.998	409	.	.	.	.	GCN1	109	0	127	8	0.0592592592592593	TRUE	TRUE
ENSG00000102539.5	.	BCM	GRCh38.p13	chr13	49222354	49222354	+	G	G	A	Missense_Mutation	SNP	ENST00000218721.1	exon2	c.G1216A	p.A406T	exonic	ENSG00000102539.5	.	nonsynonymous SNV	ENSG00000102539.5:ENST00000218721.1:exon2:c.G1216A:p.A406T	13q14.2	C3N-03006	1.862e-05	0	0	0	0	3.324e-05	0	0	rs200236330	0.20	T	T	B	B	N	N	L	T	N	0.062	T	T	T	0.064	.	0.357	.	T	T	T	T	T	T	-0.155	0.637	0.908	N	N	-1.488	0.085	-1.568	0.084	1.000	0.598	0.590	0.596	0.530	.	5.210	-6.040	-1.538	-0.704	-0.113	0.000	0.000	0.001	665	.	.	.	ID=COSV99519844;OCCURENCE=1(endometrium)	MLNR	171	1	193	11	0.053921568627451	TRUE	NA
ENSG00000182950.3	.	BCM	GRCh38.p13	chr15	75726093	75726093	+	C	C	T	Missense_Mutation	SNP	ENST00000332145.3	exon3	c.C265T	p.L89F	exonic	ENSG00000182950.3	.	nonsynonymous SNV	ENSG00000182950.3:ENST00000332145.3:exon3:c.C265T:p.L89F	15q24.2	C3N-03006	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.166	T	T	T	0.039	0.488	0.014	0.252	T	T	T	T	T	T	0.032	1.551	0.762	N	N	-1.569	0.062	-1.480	0.116	0.997	0.549	0.588	0.479	0.616	.	5.180	0.132	0.384	-0.634	-1.601	0.006	0.808	0.366	166	.	.	.	.	ODF3L1	173	0	199	13	0.0613207547169811	TRUE	TRUE
ENSG00000174938.14	.	BCM	GRCh38.p13	chr16	29873661	29873661	+	C	C	A	Missense_Mutation	SNP	ENST00000308713.9	exon13	c.G2173T	p.V725F	exonic	ENSG00000174938.14	.	nonsynonymous SNV	ENSG00000174938.14:ENST00000308713.9:exon13:c.G2173T:p.V725F	16p11.2	C3N-03006	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	N	D	L	T	D	0.732	T	T	D	0.366	0.712	0.682	1.230	T	T	T	T	D	D	3.168	23.800	0.996	D	D	0.328	3.928	0.331	3.903	0.928	0.696	0.610	0.723	0.586	.	4.670	3.600	1.929	1.026	0.599	0.941	0.915	0.586	245	Sushi/SCR/CCP_domain	.	.	ID=COSV100435497;OCCURENCE=1(lung)	SEZ6L2	237	0	294	20	0.0636942675159236	TRUE	TRUE
ENSG00000197162.10	.	BCM	GRCh38.p13	chr16	30585560	30585560	+	G	G	A	Missense_Mutation	SNP	ENST00000395216.3	exon1	c.C52T	p.P18S	exonic	ENSG00000197162.10	.	nonsynonymous SNV	ENSG00000197162.10:ENST00000395216.3:exon1:c.C52T:p.P18S	16p11.2	C3N-03006	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.058	T	T	T	0.012	0.193	0.040	0.457	T	T	T	T	T	T	0.147	2.545	0.824	N	N	-1.267	0.183	-1.310	0.203	1.000	0.267	0.219	0.520	0.250	.	2.820	-1.350	0.093	-1.305	-0.323	0.003	0.000	0.000	175	.	.	.	.	ZNF785	150	1	188	14	0.0693069306930693	TRUE	NA
ENSG00000125107.18	.	BCM	GRCh38.p13	chr16	58537929	58537929	+	C	C	T	Missense_Mutation	SNP	ENST00000317147.10	exon38	c.G5376A	p.M1792I	exonic	ENSG00000125107.18	.	nonsynonymous SNV	ENSG00000125107.18:ENST00000317147.10:exon38:c.G5376A:p.M1792I	16q21	C3N-03006	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	N	D	N	T	N	0.605	T	T	T	0.157	0.495	0.238	1.273	D	T	T	T	D	D	2.330	21.700	0.971	D	D	-0.034	2.394	0.168	3.030	1.000	0.707	0.725	0.702	0.714	.	5.650	4.690	7.905	1.026	0.599	1.000	1.000	0.995	693	.	.	.	.	CNOT1	165	0	206	12	0.055045871559633	TRUE	TRUE
ENSG00000159842.15	.	BCM	GRCh38.p13	chr17	1125298	1125298	+	G	G	A	Missense_Mutation	SNP	ENST00000302538.9	exon2	c.C131T	p.S44L	exonic	ENSG00000159842.15	.	nonsynonymous SNV	ENSG00000159842.15:ENST00000302538.9:exon2:c.C131T:p.S44L	17p13.3	C3N-03006	.	.	.	.	.	.	.	.	.	6.20	T	T	P	B	D	D	L	T	N	0.826	T	T	T	0.201	0.352	0.787	2.089	T	T	T	T	D	D	3.658	25.200	0.999	D	D	0.265	3.606	0.393	4.308	1.000	0.706	0.644	0.723	0.613	.	5.360	5.360	8.620	1.158	0.656	1.000	0.990	0.991	933	.	.	.	.	ABR	173	0	201	12	0.0563380281690141	TRUE	TRUE
ENSG00000033627.16	.	BCM	GRCh38.p13	chr17	42494444	42494444	+	C	C	G	Missense_Mutation	SNP	ENST00000343619.8	exon12	c.C1285G	p.R429G	exonic	ENSG00000033627.16	.	nonsynonymous SNV	ENSG00000033627.16:ENST00000343619.8:exon12:c.C1285G:p.R429G	17q21.2	C3N-03006	.	.	.	.	.	.	.	.	.	16.20	T	T	D	D	D	D	M	D	N	0.671	D	D	D	0.537	0.551	0.397	2.209	T	D	D	D	D	D	2.710	22.800	0.991	D	D	0.215	3.369	0.344	3.984	0.993	0.732	0.725	0.725	0.728	.	5.610	5.610	3.327	1.026	0.599	1.000	1.000	0.995	163	.	.	.	.	ATP6V0A1	170	0	189	12	0.0597014925373134	TRUE	TRUE
ENSG00000187867.10	.	BCM	GRCh38.p13	chr19	14057431	14057431	+	C	C	G	Missense_Mutation	SNP	ENST00000340790.9	exon2	c.G46C	p.E16Q	exonic	ENSG00000187867.10	.	nonsynonymous SNV	ENSG00000187867.10:ENST00000340790.9:exon2:c.G46C:p.E16Q	19p13.12	C3N-03006	.	.	.	.	.	.	.	.	.	10.19	D	D	D	D	.	N	M	T	N	0.455	T	T	D	0.143	0.230	0.170	.	D	T	T	T	D	D	5.389	34	0.993	D	N	0.348	4.040	0.275	3.577	1.000	0.726	0.596	0.594	0.568	.	3.930	2.860	2.083	0.770	0.494	1.000	1.000	0.828	824	.	.	.	.	PALM3	77	0	88	5	0.0537634408602151	TRUE	TRUE
ENSG00000187135.7	.	BCM	GRCh38.p13	chr19	29530089	29530089	+	C	C	T	Missense_Mutation	SNP	ENST00000335523.7	exon4	c.C568T	p.R190C	exonic	ENSG00000187135.7	.	nonsynonymous SNV	ENSG00000187135.7:ENST00000335523.7:exon4:c.C568T:p.R190C	19q12	C3N-03006	.	.	.	.	.	.	.	.	.	7.20	D	D	D	B	N	N	M	T	D	0.235	T	T	D	0.268	0.356	0.318	.	D	T	T	T	T	T	2.869	23.200	0.997	N	N	-0.348	1.501	-0.468	1.254	0.994	0.598	0.596	0.504	0.639	.	3.710	3.710	0.582	0.928	0.456	0.057	0.010	0.033	968	.	.	.	.	VSTM2B	419	0	641	60	0.0855920114122682	TRUE	NA
ENSG00000275395.6	.	BCM	GRCh38.p13	chr19	39886381	39886381	+	C	C	T	Missense_Mutation	SNP	ENST00000616721.6	exon16	c.G7798A	p.D2600N	exonic	ENSG00000275395.6	.	nonsynonymous SNV	ENSG00000275395.6:ENST00000616721.6:exon16:c.G7798A:p.D2600N	19q13.2	C3N-03006	.	.	.	.	.	.	.	.	.	4.13	.	D	.	.	.	N	.	.	.	.	T	T	T	0.125	.	0.659	.	T	T	T	T	D	T	2.486	22.400	0.998	D	D	-0.166	1.975	-0.156	1.894	0.080	0.554	0.588	0.602	0.621	.	3.710	2.660	1.997	-0.286	0.308	0.907	0.986	0.616	707	von_Willebrand_factor,_type_D_domain	.	.	.	FCGBP	1220	0	2737	228	0.0768971332209106	NA	TRUE
ENSG00000126464.14	.	BCM	GRCh38.p13	chr19	49595423	49595423	+	C	C	T	Missense_Mutation	SNP	ENST00000418929.7	exon4	c.C1088T	p.T363M	exonic	ENSG00000126464.14	.	nonsynonymous SNV	ENSG00000126464.14:ENST00000418929.7:exon4:c.C1088T:p.T363M	19q13.33	C3N-03006	9.285e-05	0	0	0	0	0.0003	0	0	rs759637531	3.16	D	T	B	B	.	N	.	.	N	0.127	T	T	D	0.178	.	0.068	0.454	D	.	T	T	T	T	1.414	15.180	0.822	N	N	-0.451	1.275	-0.522	1.167	0.999	0.651	0.709	0.645	0.605	.	3.830	3.830	0.192	0.097	0.599	0.000	0.028	0.575	753	.	.	.	.	PRR12	109	0	129	14	0.0979020979020979	TRUE	NA
ENSG00000186976.15	.	BCM	GRCh38.p13	chr22	43554895	43554895	+	G	G	A	Missense_Mutation	SNP	ENST00000262726.12	exon27	c.C3622T	p.R1208C	exonic	ENSG00000186976.15	.	nonsynonymous SNV	ENSG00000186976.15:ENST00000262726.12:exon27:c.C3622T:p.R1208C	22q13.2	C3N-03006	2.471e-05	0	0	0	0	1.498e-05	0	0.0001	rs374118424	5.20	T	D	D	P	N	N	N	T	N	0.382	T	T	D	0.273	.	0.601	0.266	T	T	T	T	D	T	3.110	23.700	0.993	D	N	-0.605	0.978	-0.640	0.987	0.000	0.554	0.547	0.602	0.564	.	4.880	2.800	1.781	0.218	-0.114	0.925	0.006	0.013	846	EF-hand_domain;DJBP,_EF-hand_domain	.	.	.	EFCAB6	176	0	207	11	0.0504587155963303	TRUE	NA
ENSG00000189401.3	.	BCM	GRCh38.p13	chrX	70062573	70062573	+	C	C	T	Missense_Mutation	SNP	ENST00000338352.3	exon1	c.C49T	p.R17C	exonic	ENSG00000189401.3	.	nonsynonymous SNV	ENSG00000189401.3:ENST00000338352.3:exon1:c.C49T:p.R17C	Xq13.1	C3N-03006	1.501e-05	0.0001	0	0	0	0	0	0	rs760944430	8.19	D	D	B	B	D	N	M	T	D	0.249	T	T	D	0.119	0.239	0.231	1.605	T	T	T	T	D	D	1.476	15.590	0.993	N	.	.	.	.	.	0.000	.	.	.	.	.	4.220	3.350	0.340	0.128	-0.239	0.000	0.005	0.000	170	.	.	.	ID=COSV57972949;OCCURENCE=2(large_intestine),1(haematopoietic_and_lymphoid_tissue)	OTUD6A	173	1	172	30	0.148514851485149	TRUE	TRUE
ENSG00000175718.10	.	BCM	GRCh38.p13	chrX	115191788	115191788	+	C	C	T	Nonsense_Mutation	SNP	ENST00000424776.5	exon1	c.C2347T	p.R783X	exonic	ENSG00000175718.10	.	stopgain	ENSG00000175718.10:ENST00000424776.5:exon1:c.C2347T:p.R783X	Xq23	C3N-03006	.	.	.	.	.	.	.	.	.	3.4	.	.	.	.	.	D	.	.	.	0.024	.	.	.	.	.	.	.	.	.	D	D	.	.	5.134	33	0.987	N	.	.	.	.	.	0.016	.	.	.	.	.	0.920	-0.333	0.136	0.319	0.268	0.262	0.002	0.002	937	.	.	.	ID=COSV100407349;OCCURENCE=1(endometrium)	RBMXL3	445	0	484	49	0.0919324577861163	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675237	7675237	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon5:c.376-1G>A	.	.	17p13.1	C3N-03006	.	.	.	.	.	.	.	.	rs868137297	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.764	34	0.992	D	.	1.034	15.036	0.849	11.733	1.000	0.284	0.272	0.299	0.344	0.828	4.870	3.900	7.742	1.026	0.599	1.000	0.929	0.884	434	.	.	.	ID=COSV52688618;OCCURENCE=14(breast),7(liver),6(oesophagus),10(large_intestine),5(central_nervous_system),1(biliary_tract),1(fallopian_tube),5(ovary),1(NS),6(haematopoietic_and_lymphoid_tissue),4(stomach),2(soft_tissue),1(urinary_tract),8(pancreas),1(skin),2(prostate),2(lung),4(upper_aerodigestive_tract)	TP53	264	0	237	28	0.105660377358491	TRUE	TRUE
ENSG00000102287.19	.	BCM	GRCh38.p13	chrX	151959837	151959837	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000102287.19	ENST00000370328.4:exon6:c.784+2T>C	.	.	Xq28	C3N-03006	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	4.187	28.500	0.949	D	.	.	.	.	.	1.000	.	.	.	.	0.691	5.520	5.520	8.309	1.207	0.756	1.000	0.083	0.090	778	.	.	.	.	GABRE	100	0	139	12	0.0794701986754967	TRUE	TRUE
ENSG00000134698.11	.	BCM	GRCh38.p13	chr1	35825679	35825679	+	G	G	A	Silent	SNP	ENST00000373210.4	exon5	c.G489A	p.R163R	exonic	ENSG00000134698.11	.	synonymous SNV	ENSG00000134698.11:ENST00000373210.4:exon5:c.G489A:p.R163R	1p34.3	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AGO4	24	0	33	5	0.131578947368421	NA	TRUE
ENSG00000136630.13	.	BCM	GRCh38.p13	chr1	220880100	220880100	+	G	G	C	Silent	SNP	ENST00000366903.8	exon1	c.G243C	p.P81P	exonic	ENSG00000136630.13	.	synonymous SNV	ENSG00000136630.13:ENST00000366903.8:exon1:c.G243C:p.P81P	1q41	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HLX	130	0	148	8	0.0512820512820513	TRUE	TRUE
ENSG00000114349.10	.	BCM	GRCh38.p13	chr3	50193655	50193655	+	G	G	A	Silent	SNP	ENST00000232461.8	exon4	c.G441A	p.S147S	exonic	ENSG00000114349.10	.	synonymous SNV	ENSG00000114349.10:ENST00000232461.8:exon4:c.G441A:p.S147S	3p21.31	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50029261;OCCURENCE=1(stomach)	GNAT1	394	0	394	21	0.0506024096385542	TRUE	TRUE
ENSG00000145147.20	.	BCM	GRCh38.p13	chr4	20268810	20268810	+	G	G	A	Silent	SNP	ENST00000504154.6	exon4	c.G324A	p.L108L	exonic	ENSG00000145147.20	.	synonymous SNV	ENSG00000145147.20:ENST00000504154.6:exon4:c.G324A:p.L108L	4p15.31	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLIT2	152	0	212	23	0.0978723404255319	TRUE	TRUE
ENSG00000040731.10	.	BCM	GRCh38.p13	chr5	24537522	24537522	+	G	G	A	Silent	SNP	ENST00000264463.8	exon3	c.C384T	p.R128R	exonic	ENSG00000040731.10	.	synonymous SNV	ENSG00000040731.10:ENST00000264463.8:exon3:c.C384T:p.R128R	5p14.2	C3N-03006	8.249e-06	0	0	0	0	0	0	6.058e-05	rs768905224	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52568657;OCCURENCE=6(oesophagus),1(large_intestine),1(stomach),2(upper_aerodigestive_tract)	CDH10	401	0	501	97	0.162207357859532	TRUE	TRUE
ENSG00000204052.4	.	BCM	GRCh38.p13	chr6	43508893	43508893	+	C	C	T	Silent	SNP	ENST00000372441.1	exon2	c.G300A	p.A100A	exonic	ENSG00000204052.4	.	synonymous SNV	ENSG00000204052.4:ENST00000372441.1:exon2:c.G300A:p.A100A	6p21.1	C3N-03006	1.927e-05	0	0	0.0003	0	0	0	0	rs746724447	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99447762;OCCURENCE=2(large_intestine),1(skin)	LRRC73	73	0	80	6	0.0697674418604651	TRUE	NA
ENSG00000058404.20	.	BCM	GRCh38.p13	chr7	44229416	44229416	+	C	C	T	Silent	SNP	ENST00000395749.7	exon18	c.G1311A	p.P437P	exonic	ENSG00000058404.20	.	synonymous SNV	ENSG00000058404.20:ENST00000395749.7:exon18:c.G1311A:p.P437P	7p13	C3N-03006	0.0012	0	0	0	0.025	0.0002	0	0.0029	rs575970166	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CAMK2B	64	0	88	6	0.0638297872340425	TRUE	NA
ENSG00000105792.19	.	BCM	GRCh38.p13	chr7	90271545	90271545	+	A	A	T	Silent	SNP	ENST00000389297.8	exon7	c.A552T	p.S184S	exonic	ENSG00000105792.19	.	synonymous SNV	ENSG00000105792.19:ENST00000389297.8:exon7:c.A552T:p.S184S	7q21.13	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CFAP69	73	0	110	9	0.0756302521008403	TRUE	TRUE
ENSG00000128564.7	.	BCM	GRCh38.p13	chr7	101164094	101164094	+	T	T	A	Silent	SNP	ENST00000249330.3	exon2	c.A750T	p.G250G	exonic	ENSG00000128564.7	.	synonymous SNV	ENSG00000128564.7:ENST00000249330.3:exon2:c.A750T:p.G250G	7q22.1	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VGF	35	0	59	9	0.132352941176471	TRUE	TRUE
ENSG00000170279.3	.	BCM	GRCh38.p13	chr7	148614122	148614122	+	G	G	A	Silent	SNP	ENST00000307003.3	exon2	c.G285A	p.P95P	exonic	ENSG00000170279.3	.	synonymous SNV	ENSG00000170279.3:ENST00000307003.3:exon2:c.G285A:p.P95P	7q36.1	C3N-03006	0.0033	0.0355	0.0014	0	0	0.0001	0.0011	0.0002	rs6965813	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C7orf33	368	0	450	27	0.0566037735849057	TRUE	NA
ENSG00000165895.19	.	BCM	GRCh38.p13	chr11	100948463	100948463	+	G	G	A	Silent	SNP	ENST00000298815.13	exon11	c.G1050A	p.G350G	exonic	ENSG00000165895.19	.	synonymous SNV	ENSG00000165895.19:ENST00000298815.13:exon11:c.G1050A:p.G350G	11q22.1	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARHGAP42	107	0	173	13	0.0698924731182796	TRUE	NA
ENSG00000111077.18	.	BCM	GRCh38.p13	chr12	53060735	53060735	+	C	C	T	Silent	SNP	ENST00000314250.11	exon20	c.C2829T	p.G943G	exonic	ENSG00000111077.18	.	synonymous SNV	ENSG00000111077.18:ENST00000314250.11:exon20:c.C2829T:p.G943G	12q13.13	C3N-03006	1.76e-05	0	0	0	0	1.576e-05	0	7.458e-05	rs771398245	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TNS2	104	0	98	10	0.0925925925925926	TRUE	NA
ENSG00000103522.16	.	BCM	GRCh38.p13	chr16	27442969	27442969	+	G	G	A	Silent	SNP	ENST00000337929.8	exon5	c.G360A	p.P120P	exonic	ENSG00000103522.16	.	synonymous SNV	ENSG00000103522.16:ENST00000337929.8:exon5:c.G360A:p.P120P	16p12.1	C3N-03006	0.0004	0.0038	0.0008	0	0	4.537e-05	0	0	rs141558701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100559836;OCCURENCE=1(stomach)	IL21R	52	0	57	11	0.161764705882353	TRUE	NA
ENSG00000275395.6	.	BCM	GRCh38.p13	chr19	39886049	39886049	+	C	C	A	Silent	SNP	ENST00000616721.6	exon16	c.G8130T	p.V2710V	exonic	ENSG00000275395.6	.	synonymous SNV	ENSG00000275395.6:ENST00000616721.6:exon16:c.G8130T:p.V2710V	19q13.2	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FCGBP	1732	1	3053	260	0.0784787201931784	NA	TRUE
ENSG00000127903.14	.	BCM	GRCh38.p13	chr19	56665082	56665082	+	G	G	A	Silent	SNP	ENST00000537055.4	exon2	c.C117T	p.A39A	exonic	ENSG00000127903.14	.	synonymous SNV	ENSG00000127903.14:ENST00000537055.4:exon2:c.C117T:p.A39A	19q13.43	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV73379736;OCCURENCE=1(liver),1(prostate)	ZNF835	428	0	438	27	0.0580645161290323	TRUE	TRUE
ENSG00000128271.22	.	BCM	GRCh38.p13	chr22	24441264	24441264	+	C	C	T	Silent	SNP	ENST00000337539.12	exon3	c.C1014T	p.L338L	exonic	ENSG00000128271.22	.	synonymous SNV	ENSG00000128271.22:ENST00000337539.12:exon3:c.C1014T:p.L338L	22q11.23	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADORA2A	140	0	134	14	0.0945945945945946	TRUE	TRUE
ENSG00000155816.20	.	BCM	GRCh38.p13	chr1	240092087	240092087	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000155816.20	ENST00000319653.14:c.-23C>T	.	.	1q43	C3N-03006	0.0002	0	0	0.005	0	0	0	0	rs775688107	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FMN2	68	0	79	16	0.168421052631579	TRUE	NA
ENSG00000158089.15	.	BCM	GRCh38.p13	chr2	31125210	31125210	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000158089.15	.	.	.	2p23.1	C3N-03006	0.0062	0	0.0035	0.0021	0.0044	0.0068	0	0.0074	rs41280621	1.18	D	T	B	B	N	N	.	T	N	0.034	T	T	T	0.062	.	0.085	0.229	T	.	T	T	T	T	-1.558	0.001	0.717	N	N	-2.318	0.002	-2.427	0.002	1.000	0.487	0.573	0.547	0.564	.	3.940	-7.880	-2.070	-2.180	-2.841	0.000	0.000	0.000	937	.	.	.	ID=COSV100204282;OCCURENCE=2(haematopoietic_and_lymphoid_tissue)	GALNT14	282	0	313	18	0.054380664652568	TRUE	NA
ENSG00000237380.7	.	BCM	GRCh38.p13	chr2	176128836	176128836	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000237380.7	.	.	.	2q31.1	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HOXD-AS2	281	0	359	43	0.106965174129353	TRUE	NA
ENSG00000248546.3	.	BCM	GRCh38.p13	chr4	164197246	164197246	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000248546.3	.	.	.	4q32.3	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANP32C	292	0	369	22	0.0562659846547315	TRUE	NA
ENSG00000198563.14	.	BCM	GRCh38.p13	chr6	31532951	31532951	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000198563.14;ENSG00000254870.5	.	.	.	6p21.33	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DDX39B	12	0	12	3	0.2	TRUE	NA
ENSG00000151914.20	.	BCM	GRCh38.p13	chr6	56692544	56692544	+	A	A	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000151914.20	.	.	.	6p12.1	C3N-03006	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DST	167	0	305	23	0.0701219512195122	TRUE	NA
ENSG00000132681.17	.	BCM	GRCh38.p13	chr1	160171253	160171253	+	G	G	A	Missense_Mutation	SNP	ENST00000368081.9	exon11	c.G1494A	p.M498I	exonic	ENSG00000132681.17	.	nonsynonymous SNV	ENSG00000132681.17:ENST00000368081.9:exon11:c.G1494A:p.M498I	1q23.2	C3N-01165	.	.	.	.	.	.	.	.	.	3.20	D	T	B	B	N	D	L	T	N	0.097	T	T	D	0.182	0.511	0.496	0.186	T	T	T	T	T	T	1.321	14.540	0.668	N	N	-0.837	0.603	-0.778	0.789	1.000	0.447	0.492	0.468	0.530	.	4.290	1.420	-1.062	0.225	-0.105	0.017	0.991	0.335	407	.	.	.	.	ATP1A4	95	0	142	11	0.0718954248366013	TRUE	TRUE
ENSG00000170128.5	.	BCM	GRCh38.p13	chr1	200873790	200873790	+	C	C	A	Missense_Mutation	SNP	ENST00000304244.5	exon1	c.C753A	p.S251R	exonic	ENSG00000170128.5	.	nonsynonymous SNV	ENSG00000170128.5:ENST00000304244.5:exon1:c.C753A:p.S251R	1q32.1	C3N-01165	.	.	.	.	.	.	.	.	.	6.20	D	T	P	P	U	D	M	T	N	0.315	T	T	D	0.262	0.932	0.648	1.756	D	T	T	T	D	T	3.028	23.500	0.997	N	N	0.138	3.039	0.022	2.436	1.000	0.495	0.617	0.479	0.555	.	4.660	4.660	0.557	0.962	0.524	0.006	0.167	0.809	814	GPCR,_rhodopsin-like,_7TM	.	.	.	GPR25	229	1	489	61	0.110909090909091	TRUE	TRUE
ENSG00000198601.3	.	BCM	GRCh38.p13	chr1	248180037	248180037	+	T	T	A	Missense_Mutation	SNP	ENST00000641211.1	exon3	c.T52A	p.F18I	exonic	ENSG00000198601.3	.	nonsynonymous SNV	ENSG00000198601.3:ENST00000641211.1:exon3:c.T52A:p.F18I	1q44	C3N-01165	.	.	.	.	.	.	.	.	.	4.20	D	D	P	P	U	N	L	T	D	0.195	T	T	T	0.049	0.441	0.113	0.216	T	T	T	T	D	T	1.179	13.470	0.958	N	N	-0.540	1.098	-0.793	0.768	0.000	0.487	0.574	0.574	0.564	.	1.440	-0.180	-3.167	0.383	0.336	0.000	0.005	0.012	976	.	.	.	.	OR2M2	147	0	283	15	0.0503355704697987	NA	TRUE
ENSG00000162981.14	.	BCM	GRCh38.p13	chr2	14634679	14634679	+	G	G	C	Missense_Mutation	SNP	ENST00000295092.3	exon2	c.G700C	p.A234P	exonic	ENSG00000162981.14	.	nonsynonymous SNV	ENSG00000162981.14:ENST00000295092.3:exon2:c.G700C:p.A234P	2p24.3	C3N-01165	.	.	.	.	.	.	.	.	.	4.19	T	T	P	B	.	D	L	T	N	0.556	T	T	D	0.159	0.169	0.514	0.604	T	T	T	T	T	T	2.943	23.300	0.983	D	D	-0.038	2.377	0.007	2.385	1.000	0.652	0.563	0.641	0.639	.	4.450	4.450	2.650	1.164	0.662	0.820	0.803	0.889	957	.	.	.	.	LRATD1	28	0	66	4	0.0571428571428571	TRUE	NA
ENSG00000189350.12	.	BCM	GRCh38.p13	chr2	29033005	29033005	+	T	T	C	Missense_Mutation	SNP	ENST00000379558.4	exon15	c.T2084C	p.L695P	exonic	ENSG00000189350.12	.	nonsynonymous SNV	ENSG00000189350.12:ENST00000379558.4:exon15:c.T2084C:p.L695P	2p23.2	C3N-01165	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	D	D	.	T	D	0.781	T	T	D	0.267	0.624	0.490	0.442	T	T	T	T	D	T	3.524	24.800	0.998	D	D	0.322	3.894	0.230	3.336	1.000	0.549	0.627	0.602	0.550	.	5.120	3.930	4.228	1.138	0.665	0.628	0.635	0.062	446	TOG_domain	.	.	.	TOGARAM2	300	0	496	42	0.0780669144981413	TRUE	TRUE
ENSG00000091106.19	.	BCM	GRCh38.p13	chr2	32250951	32250951	+	C	C	T	Missense_Mutation	SNP	ENST00000402280.6	exon4	c.G913A	p.A305T	exonic	ENSG00000091106.19	.	nonsynonymous SNV	ENSG00000091106.19:ENST00000402280.6:exon4:c.G913A:p.A305T	2p22.3	C3N-01165	3.296e-05	0.0002	0	0.0001	0	1.499e-05	0	0	rs374259187	4.18	T	.	D	D	D	.	N	T	N	0.326	T	T	D	0.332	.	0.852	0.730	T	T	T	T	T	T	2.052	19.650	0.664	N	N	-0.227	1.801	-0.338	1.487	1.000	0.549	0.588	0.574	0.616	.	3.260	3.260	1.241	0.680	0.477	0.981	0.003	0.008	363	NACHT_nucleoside_triphosphatase	.	.	ID=COSV61593125;OCCURENCE=1(central_nervous_system),1(lung),1(endometrium)	NLRC4	310	1	588	50	0.0783699059561129	TRUE	TRUE
ENSG00000171951.5	.	BCM	GRCh38.p13	chr2	223598681	223598681	+	A	A	G	Missense_Mutation	SNP	ENST00000305409.3	exon2	c.T602C	p.V201A	exonic	ENSG00000171951.5	.	nonsynonymous SNV	ENSG00000171951.5:ENST00000305409.3:exon2:c.T602C:p.V201A	2q36.1	C3N-01165	.	.	.	.	.	.	.	.	.	8.20	T	T	P	P	D	D	M	T	D	0.855	T	T	T	0.377	0.774	0.433	0.356	T	T	D	T	D	T	3.284	24.100	0.997	D	D	0.647	6.436	0.684	7.465	1.000	0.615	0.610	0.659	0.542	.	5.650	5.650	8.911	1.312	0.691	1.000	0.999	0.997	940	.	.	.	ID=COSV59539803;OCCURENCE=2(lung)	SCG2	284	0	467	68	0.127102803738318	TRUE	TRUE
ENSG00000163956.13	.	BCM	GRCh38.p13	chr4	3532276	3532276	+	G	G	A	Missense_Mutation	SNP	ENST00000650182.1	exon1	c.C137T	p.P46L	exonic	ENSG00000163956.13	.	nonsynonymous SNV	ENSG00000163956.13:ENST00000650182.1:exon1:c.C137T:p.P46L	4p16.3	C3N-01165	.	.	.	.	.	.	.	.	.	0.20	T	T	P	B	N	N	L	T	N	0.060	T	T	T	0.023	0.392	0.534	0.058	T	T	T	T	T	T	0.867	10.090	0.841	N	N	-0.781	0.683	-0.913	0.603	1.000	0.442	0.522	0.522	0.562	.	3.450	1.680	0.342	-0.378	-0.789	0.000	0.004	0.019	906	Alpha-2-macroglobulin_receptor-associated_protein,_domain_1	.	.	.	LRPAP1	283	0	677	73	0.0973333333333333	TRUE	TRUE
ENSG00000086570.12	.	BCM	GRCh38.p13	chr5	151568301	151568301	+	C	C	T	Missense_Mutation	SNP	ENST00000261800.5	exon1	c.G631A	p.V211I	exonic	ENSG00000086570.12	.	nonsynonymous SNV	ENSG00000086570.12:ENST00000261800.5:exon1:c.G631A:p.V211I	5q33.1	C3N-01165	9.072e-05	0.0006	0	0	0	4.502e-05	0.0011	6.068e-05	rs201835676	0.20	T	T	P	B	N	N	N	T	N	0.073	T	T	T	0.103	.	0.575	0.255	T	T	T	T	T	T	1.605	16.410	0.995	N	N	-0.084	2.225	-0.005	2.342	1.000	0.487	0.563	0.574	0.542	.	5.610	5.610	0.319	1.026	0.599	0.022	0.981	0.934	889	Cadherin-like	.	.	ID=COSV99944273;OCCURENCE=1(endometrium)	FAT2	171	0	333	49	0.128272251308901	TRUE	NA
ENSG00000111913.20	.	BCM	GRCh38.p13	chr6	24873699	24873699	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000259698.9	exon3	c.201dupA	p.E68Rfs*5	exonic	ENSG00000111913.20	.	frameshift insertion	ENSG00000111913.20:ENST00000259698.9:exon3:c.201dupA:p.E68Rfs*5	6p22.3	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RIPOR2	NA	NA	NA	NA	NA	NA	NA
ENSG00000166508.18	.	BCM	GRCh38.p13	chr7	100097352	100097352	+	C	C	G	Missense_Mutation	SNP	ENST00000303887.10	exon10	c.G1150C	p.G384R	exonic	ENSG00000166508.18	.	nonsynonymous SNV	ENSG00000166508.18:ENST00000303887.10:exon10:c.G1150C:p.G384R	7q22.1	C3N-01165	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.936	D	D	D	0.861	0.905	0.996	0.664	D	T	D	D	D	D	3.572	24.900	0.999	D	D	0.950	12.429	0.816	10.619	1.000	0.672	0.698	0.702	0.711	.	4.970	4.970	2.060	1.026	0.599	0.168	1.000	0.999	182	AAA+_ATPase_domain;MCM_domain	.	.	.	MCM7	228	0	428	32	0.0695652173913043	TRUE	TRUE
ENSG00000107186.16	.	BCM	GRCh38.p13	chr9	13219761	13219761	+	C	C	T	Missense_Mutation	SNP	ENST00000319217.11	exon8	c.G884A	p.R295H	exonic	ENSG00000107186.16	.	nonsynonymous SNV	ENSG00000107186.16:ENST00000319217.11:exon8:c.G884A:p.R295H	9p23	C3N-01165	3.352e-05	0	0	0	0	1.512e-05	0	0.0002	rs746099118	13.19	D	D	D	D	N	D	M	T	D	0.580	T	T	D	0.467	0.731	0.577	.	T	T	D	D	D	D	3.308	24.100	0.999	D	.	0.859	10.042	0.804	10.237	1.000	0.707	0.574	0.725	0.714	.	6.170	6.170	5.649	-0.232	-0.845	1.000	0.989	0.430	607	PDZ_domain	.	.	.	MPDZ	182	0	302	39	0.114369501466276	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-01165	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	293	0	571	60	0.0950871632329636	TRUE	TRUE
ENSG00000100473.18	.	BCM	GRCh38.p13	chr14	30879441	30879443	+	AGG	AGG	-	In_Frame_Del	DEL	ENST00000396618.9	exon6	c.392_394del	p.E132del	exonic	ENSG00000100473.18	.	nonframeshift deletion	ENSG00000100473.18:ENST00000396618.9:exon6:c.392_394del:p.E132del	14q12	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COCH	397	0	677	63	0.0851351351351351	TRUE	TRUE
ENSG00000140400.17	.	BCM	GRCh38.p13	chr15	75356866	75356866	+	C	C	T	Missense_Mutation	SNP	ENST00000267978.10	exon22	c.G2584A	p.G862S	exonic	ENSG00000140400.17	.	nonsynonymous SNV	ENSG00000140400.17:ENST00000267978.10:exon22:c.G2584A:p.G862S	15q24.2	C3N-01165	0.0001	9.66e-05	0	0	0	0.0001	0.0011	0.0003	rs369832470	9.20	D	D	P	B	N	D	M	T	D	0.513	T	T	D	0.118	.	0.547	0.144	T	D	T	T	T	D	1.975	19.060	0.995	D	N	0.183	3.230	0.179	3.080	1.000	0.707	0.644	0.607	0.714	.	5.090	3.210	3.790	1.026	0.597	1.000	0.070	0.350	514	Glycosyl_hydrolase_family_38,_C-terminal	.	.	.	MAN2C1	276	0	571	103	0.152818991097923	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673802	7673802	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G818A	p.R273H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G818A:p.R273H	17p13.1	C3N-01165	2.628e-05	0	0	0	0	4.746e-05	0	0	rs28934576	19.20	D	D	D	D	D	A	M	D	D	0.965	D	D	D	0.868	.	0.997	0.264	T	D	D	D	D	D	3.527	24.800	0.998	D	D	0.383	4.238	0.333	3.915	1.000	0.722	0.702	0.725	0.735	.	4.920	4.920	7.905	1.022	0.596	1.000	0.856	0.980	432	p53,_DNA-binding_domain	.	.	ID=COSV52660980;OCCURENCE=3(salivary_gland),135(breast),5(penis),9(liver),2(genital_tract),55(oesophagus),3(adrenal_gland),1(cervix),301(large_intestine),84(central_nervous_system),18(biliary_tract),1(fallopian_tube),1(pleura),4(vulva),73(ovary),8(bone),6(NS),57(haematopoietic_and_lymphoid_tissue),60(stomach),23(urinary_tract),7(soft_tissue),9(kidney),55(pancreas),15(skin),22(prostate),111(lung),11(thyroid),66(upper_aerodigestive_tract),2(thymus),41(endometrium)	TP53	585	1	993	123	0.110215053763441	TRUE	TRUE
ENSG00000153822.13	.	BCM	GRCh38.p13	chr17	70132825	70132825	+	C	C	G	Missense_Mutation	SNP	ENST00000615244.4	exon6	c.C738G	p.I246M	exonic	ENSG00000153822.13	.	nonsynonymous SNV	ENSG00000153822.13:ENST00000615244.4:exon6:c.C738G:p.I246M	17q24.3	C3N-01165	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	D	D	L	D	N	0.766	D	D	D	0.513	0.685	0.830	0.423	T	T	D	T	D	T	2.524	22.500	0.991	D	D	-0.165	1.975	-0.226	1.725	0.063	0.487	0.590	0.574	0.613	.	5.740	0.349	0.022	0.130	-0.176	0.835	0.979	0.810	884	.	.	.	.	KCNJ16	384	0	688	70	0.0923482849604222	TRUE	TRUE
ENSG00000105426.17	.	BCM	GRCh38.p13	chr19	5274306	5274306	+	C	C	T	Missense_Mutation	SNP	ENST00000587303.5	exon2	c.G130A	p.G44S	exonic	ENSG00000105426.17	.	nonsynonymous SNV	ENSG00000105426.17:ENST00000587303.5:exon2:c.G130A:p.G44S	19p13.3	C3N-01165	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	N	D	N	T	D	0.841	T	T	D	0.413	0.400	0.518	.	D	D	D	D	D	D	2.498	22.400	0.997	D	D	0.248	3.523	0.227	3.319	1.000	0.672	0.634	0.702	0.655	.	3.700	3.700	7.704	0.947	0.599	1.000	0.305	0.829	988	Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV53609338;OCCURENCE=2(large_intestine)	PTPRS	103	0	231	27	0.104651162790698	TRUE	TRUE
ENSG00000178386.13	.	BCM	GRCh38.p13	chr19	44067156	44067156	+	G	G	A	Missense_Mutation	SNP	ENST00000434772.8	exon5	c.G1328A	p.R443H	exonic	ENSG00000178386.13;ENSG00000267022.1	.	nonsynonymous SNV	ENSG00000178386.13:ENST00000434772.8:exon5:c.G1328A:p.R443H,ENSG00000267022.1:ENST00000591793.1:exon7:c.G1658A:p.R553H	19q13.31	C3N-01165	2.476e-05	9.679e-05	8.643e-05	0	0	1.502e-05	0	0	rs777005275	3.19	D	D	D	P	.	N	N	T	N	0.035	T	T	T	0.051	0.474	0.171	0.151	T	T	T	T	T	T	1.988	19.160	0.992	N	N	-0.703	0.808	-0.934	0.575	0.000	0.563	0.588	0.609	0.636	.	2.460	0.152	-0.359	-1.160	-0.483	0.000	0.000	0.076	611	Zinc_finger_C2H2-type	.	.	ID=COSV69691221;OCCURENCE=1(large_intestine),1(endometrium)	ZNF223	173	0	363	33	0.0833333333333333	TRUE	TRUE
ENSG00000101222.12	.	BCM	GRCh38.p13	chr20	3779306	3779306	+	G	G	A	Missense_Mutation	SNP	ENST00000379756.3	exon3	c.C268T	p.R90C	exonic	ENSG00000101222.12	.	nonsynonymous SNV	ENSG00000101222.12:ENST00000379756.3:exon3:c.C268T:p.R90C	20p13	C3N-01165	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	N	D	M	T	D	0.509	T	T	T	0.203	0.636	0.254	1.557	T	T	T	T	D	D	4.304	29.600	0.999	D	D	0.594	5.859	0.571	5.883	1.000	0.598	0.596	0.615	0.639	.	4.730	4.730	3.667	1.161	0.618	1.000	0.995	0.923	782	CH-like_domain_in_sperm_protein;Calponin_homology_domain	.	.	.	SPEF1	62	0	210	23	0.0987124463519313	TRUE	TRUE
ENSG00000130699.18	.	BCM	GRCh38.p13	chr20	62065242	62065242	+	G	G	A	Missense_Mutation	SNP	ENST00000252996.8	exon1	c.C569T	p.A190V	exonic	ENSG00000130699.18	.	nonsynonymous SNV	ENSG00000130699.18:ENST00000252996.8:exon1:c.C569T:p.A190V	20q13.33	C3N-01165	.	.	.	.	.	.	.	.	.	2.19	D	T	B	B	U	N	N	T	N	0.214	T	T	D	0.051	0.161	0.408	0.685	T	T	T	T	T	T	1.241	13.950	0.978	N	.	-1.190	0.234	-1.215	0.271	1.000	0.455	0.609	0.507	0.555	.	1.780	-3.560	-0.124	0.678	0.133	0.959	0.986	0.410	934	.	.	.	.	TAF4	40	0	153	15	0.0892857142857143	TRUE	NA
ENSG00000185222.10	.	BCM	GRCh38.p13	chrX	103357883	103357883	+	A	A	G	Missense_Mutation	SNP	ENST00000372661.6	exon3	c.A199G	p.N67D	exonic	ENSG00000185222.10	.	nonsynonymous SNV	ENSG00000185222.10:ENST00000372661.6:exon3:c.A199G:p.N67D	Xq22.2	C3N-01165	.	.	.	.	.	.	.	.	.	2.18	T	T	B	B	N	N	.	T	D	0.213	T	T	T	0.137	0.547	0.294	0.066	T	T	T	T	T	T	1.563	16.140	0.966	D	.	.	.	.	.	1.000	.	.	.	.	.	4.040	4.040	0.705	1.207	0.756	1.000	0.997	0.998	245	.	.	.	.	TCEAL9	323	0	515	64	0.110535405872193	TRUE	TRUE
ENSG00000123165.8	.	BCM	GRCh38.p13	chrX	128051516	128051516	+	G	G	A	Missense_Mutation	SNP	ENST00000371124.4	exon1	c.C691T	p.R231C	exonic	ENSG00000123165.8	.	nonsynonymous SNV	ENSG00000123165.8:ENST00000371124.4:exon1:c.C691T:p.R231C	Xq25	C3N-01165	1.14e-05	0.0001	0	0	0	0	0	0	rs749902150	2.19	T	T	B	B	N	N	N	D	N	0.099	T	D	T	0.191	0.317	0.973	0.029	T	T	T	T	T	T	-0.493	0.123	0.555	N	.	.	.	.	.	0.001	.	.	.	.	.	3.450	-6.890	-1.470	-4.145	-4.561	0.000	0.000	0.000	900	.	.	.	ID=COSV64419079;OCCURENCE=1(large_intestine),1(ovary),1(upper_aerodigestive_tract)	ACTRT1	297	0	562	61	0.0979133226324237	TRUE	TRUE
ENSG00000163491.16	.	BCM	GRCh38.p13	chr3	27344301	27344301	+	G	G	T	Silent	SNP	ENST00000429845.6	exon6	c.C333A	p.T111T	exonic	ENSG00000163491.16	.	synonymous SNV	ENSG00000163491.16:ENST00000429845.6:exon6:c.C333A:p.T111T	3p24.1	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100412230;OCCURENCE=1(skin)	NEK10	170	0	289	35	0.108024691358025	TRUE	TRUE
ENSG00000164506.14	.	BCM	GRCh38.p13	chr6	147334203	147334203	+	C	C	T	Silent	SNP	ENST00000321680.10	exon19	c.C2127T	p.R709R	exonic	ENSG00000164506.14	.	synonymous SNV	ENSG00000164506.14:ENST00000321680.10:exon19:c.C2127T:p.R709R	6q24.3	C3N-01165	1.654e-05	0	0	0	0	0	0	0.0001	rs747661250	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STXBP5	184	0	335	40	0.106666666666667	TRUE	NA
ENSG00000165061.15	.	BCM	GRCh38.p13	chr8	40674708	40674708	+	C	C	T	Silent	SNP	ENST00000297737.11	exon5	c.G573A	p.L191L	exonic	ENSG00000165061.15	.	synonymous SNV	ENSG00000165061.15:ENST00000297737.11:exon5:c.G573A:p.L191L	8p11.21	C3N-01165	3.299e-05	0	0	0	0	4.5e-05	0	6.064e-05	rs753809814	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52704254;OCCURENCE=1(cervix)	ZMAT4	136	0	339	28	0.0762942779291553	TRUE	TRUE
ENSG00000169122.11	.	BCM	GRCh38.p13	chr8	58146749	58146749	+	C	C	T	Silent	SNP	ENST00000361488.7	exon5	c.C519T	p.S173S	exonic	ENSG00000169122.11	.	synonymous SNV	ENSG00000169122.11:ENST00000361488.7:exon5:c.C519T:p.S173S	8q12.1	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM110B	113	0	191	22	0.103286384976526	TRUE	TRUE
ENSG00000079102.16	.	BCM	GRCh38.p13	chr8	91970727	91970727	+	G	G	A	Silent	SNP	ENST00000613302.4	exon13	c.C1470T	p.V490V	exonic	ENSG00000079102.16	.	synonymous SNV	ENSG00000079102.16:ENST00000613302.4:exon13:c.C1470T:p.V490V	8q21.3	C3N-01165	3.3e-05	0	0	0	0	3.003e-05	0	0.0001	rs747468228	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56145882;OCCURENCE=1(stomach)	RUNX1T1	155	1	345	24	0.0650406504065041	TRUE	NA
ENSG00000048828.17	.	BCM	GRCh38.p13	chr9	93516021	93516021	+	G	G	A	Silent	SNP	ENST00000277165.11	exon7	c.G1170A	p.Q390Q	exonic	ENSG00000048828.17	.	synonymous SNV	ENSG00000048828.17:ENST00000277165.11:exon7:c.G1170A:p.Q390Q	9q22.31	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM120A	130	0	260	25	0.087719298245614	NA	TRUE
ENSG00000110274.16	.	BCM	GRCh38.p13	chr11	117396168	117396168	+	A	A	G	Silent	SNP	ENST00000278935.8	exon25	c.A3204G	p.K1068K	exonic	ENSG00000110274.16	.	synonymous SNV	ENSG00000110274.16:ENST00000278935.8:exon25:c.A3204G:p.K1068K	11q23.3	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CEP164	127	0	257	30	0.104529616724739	TRUE	TRUE
ENSG00000102054.18	.	BCM	GRCh38.p13	chrX	16853726	16853726	+	G	G	A	Silent	SNP	ENST00000380087.7	exon6	c.C714T	p.H238H	exonic	ENSG00000102054.18	.	synonymous SNV	ENSG00000102054.18:ENST00000380087.7:exon6:c.C714T:p.H238H	Xp22.2	C3N-01165	1.182e-05	0.0001	0	0	0	0	0	0	rs150009710	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBBP7	72	0	142	17	0.106918238993711	TRUE	NA
ENSG00000188917.15	.	BCM	GRCh38.p13	chrX	101022015	101022015	+	T	T	C	Silent	SNP	ENST00000372936.4	exon9	c.A804G	p.R268R	exonic	ENSG00000188917.15	.	synonymous SNV	ENSG00000188917.15:ENST00000372936.4:exon9:c.A804G:p.R268R	Xq22.1	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRMT2B	186	0	374	42	0.100961538461538	TRUE	TRUE
ENSG00000102195.10	.	BCM	GRCh38.p13	chrX	151180594	151180594	+	C	C	T	Silent	SNP	ENST00000218316.4	exon2	c.C1011T	p.R337R	exonic	ENSG00000102195.10	.	synonymous SNV	ENSG00000102195.10:ENST00000218316.4:exon2:c.C1011T:p.R337R	Xq28	C3N-01165	2.298e-05	0	0.0002	0	0	0	0	0	rs191496491	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54438686;OCCURENCE=1(liver),2(stomach),1(pancreas)	GPR50	212	1	375	50	0.117647058823529	NA	TRUE
ENSG00000179915.23	.	BCM	GRCh38.p13	chr2	50656386	50656386	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000179915.23	.	.	.	2p16.3	C3N-01165	.	.	.	.	.	.	.	.	.	1.3	.	.	.	.	.	N	.	.	.	0.258	.	.	.	.	.	.	.	.	.	.	.	.	D	0.631	7.811	0.559	N	.	.	.	.	.	0.011	0.054	0.063	0.060	0.057	0.046	3.030	-0.142	0.104	0.027	0.455	0.000	0.001	0.041	809	.	.	.	.	NRXN1	131	0	226	17	0.0699588477366255	TRUE	NA
ENSG00000167996.16	.	BCM	GRCh38.p13	chr11	61965565	61965565	+	T	T	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000167996.16	.	.	.	11q12.3	C3N-01165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FTH1	398	0	831	59	0.0662921348314607	TRUE	NA
ENSG00000092853.14	.	BCM	GRCh38.p13	chr1	35764555	35764555	+	G	G	A	Missense_Mutation	SNP	ENST00000318121.8	exon3	c.C293T	p.T98I	exonic	ENSG00000092853.14	.	nonsynonymous SNV	ENSG00000092853.14:ENST00000318121.8:exon3:c.C293T:p.T98I	1p34.3	C3N-03173	.	.	.	.	.	.	.	.	.	0.20	T	T	P	B	N	N	N	T	N	0.126	T	T	T	0.003	0.243	0.168	0.126	T	T	T	T	T	T	1.292	14.330	0.942	N	N	-0.676	0.853	-0.647	0.977	1.000	0.706	0.663	0.725	0.613	.	6.030	3.170	1.115	0.027	0.676	0.330	0.153	0.944	197	.	.	.	.	CLSPN	214	0	195	20	0.0930232558139535	TRUE	TRUE
ENSG00000127124.16	.	BCM	GRCh38.p13	chr1	41524878	41524878	+	C	C	T	Missense_Mutation	SNP	ENST00000372583.6	exon6	c.G5240A	p.R1747Q	exonic	ENSG00000127124.16	.	nonsynonymous SNV	ENSG00000127124.16:ENST00000372583.6:exon6:c.G5240A:p.R1747Q	1p34.2	C3N-03173	2.476e-05	0	8.651e-05	0.0001	0	1.503e-05	0	0	rs769827954	14.20	D	D	D	D	N	D	M	T	D	0.772	T	T	D	0.421	0.544	0.505	0.799	D	D	T	T	D	D	4.144	28.100	1.000	D	D	0.831	9.407	0.781	9.585	1.000	0.651	0.709	0.578	0.621	.	4.850	4.850	7.905	1.026	0.599	1.000	1.000	1.000	455	.	.	.	ID=COSV56014043;OCCURENCE=1(urinary_tract),1(skin)	HIVEP3	308	0	244	26	0.0962962962962963	TRUE	TRUE
ENSG00000162779.22	.	BCM	GRCh38.p13	chr1	179468597	179468597	+	C	C	A	Missense_Mutation	SNP	ENST00000367618.8	exon17	c.C1953A	p.N651K	exonic	ENSG00000162779.22	.	nonsynonymous SNV	ENSG00000162779.22:ENST00000367618.8:exon17:c.C1953A:p.N651K	1q25.2	C3N-03173	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.348	T	T	T	0.029	0.436	0.048	0.028	T	T	T	T	T	T	-0.406	0.187	0.249	N	N	-1.243	0.198	-1.353	0.177	0.000	0.500	0.574	0.547	0.504	.	4.240	-2.140	-1.443	0.099	-0.182	0.000	0.002	0.000	556	.	.	.	.	AXDND1	85	0	57	8	0.123076923076923	TRUE	NA
ENSG00000143493.13	.	BCM	GRCh38.p13	chr1	211944943	211944943	+	A	A	C	Missense_Mutation	SNP	ENST00000366994.8	exon19	c.T2442G	p.N814K	exonic	ENSG00000143493.13	.	nonsynonymous SNV	ENSG00000143493.13:ENST00000366994.8:exon19:c.T2442G:p.N814K	1q32.3	C3N-03173	.	.	.	.	.	.	.	.	.	6.20	T	T	P	B	D	D	N	T	N	0.405	T	T	T	0.103	0.300	0.275	0.253	D	T	T	T	D	D	1.987	19.160	0.988	D	N	-0.357	1.479	-0.231	1.714	1.000	0.778	0.725	0.854	0.711	.	5.640	3.780	0.416	0.226	-0.106	0.998	0.999	0.989	678	.	.	.	.	INTS7	155	0	160	17	0.096045197740113	TRUE	TRUE
ENSG00000135636.14	.	BCM	GRCh38.p13	chr2	71539162	71539162	+	G	G	A	Missense_Mutation	SNP	ENST00000258104.7	exon16	c.G1403A	p.R468H	exonic	ENSG00000135636.14	.	nonsynonymous SNV	ENSG00000135636.14:ENST00000258104.7:exon16:c.G1403A:p.R468H	2p13.2	C3N-03173	1.647e-05	9.612e-05	0	0	0	0	0	6.057e-05	rs775370021	17.20	D	D	D	D	D	D	M	T	D	0.753	D	D	D	0.593	0.570	0.908	0.686	T	D	T	D	D	D	4.320	29.700	0.999	D	D	0.856	9.974	0.764	9.135	1.000	0.707	0.574	0.645	0.714	.	5.050	5.050	7.027	1.176	0.676	1.000	1.000	0.983	522	Ferlin,_third_C2_domain;C2_domain	.	.	ID=COSV50269980;OCCURENCE=1(large_intestine),1(stomach)	DYSF	387	0	384	34	0.0813397129186603	TRUE	TRUE
ENSG00000163491.16	.	BCM	GRCh38.p13	chr3	27119825	27119825	+	G	G	T	Missense_Mutation	SNP	ENST00000429845.6	exon36	c.C3296A	p.T1099K	exonic	ENSG00000163491.16	.	nonsynonymous SNV	ENSG00000163491.16:ENST00000429845.6:exon36:c.C3296A:p.T1099K	3p24.1	C3N-03173	.	.	.	.	.	.	.	.	.	7.17	D	D	D	P	.	N	.	T	N	0.724	T	T	D	0.145	0.243	0.838	.	.	T	D	T	D	T	2.678	22.800	0.990	D	N	0.114	2.941	0.137	2.892	0.094	0.554	0.574	0.574	0.621	.	5.940	5.080	1.993	-0.151	-0.130	1.000	0.255	0.971	638	.	.	.	.	NEK10	232	0	211	33	0.135245901639344	TRUE	TRUE
ENSG00000114656.12	.	BCM	GRCh38.p13	chr3	128977028	128977028	+	T	T	C	Missense_Mutation	SNP	ENST00000265068.9	exon6	c.A847G	p.S283G	exonic	ENSG00000114656.12	.	nonsynonymous SNV	ENSG00000114656.12:ENST00000265068.9:exon6:c.A847G:p.S283G	3q21.3	C3N-03173	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	L	.	N	0.085	T	T	T	0.003	0.140	0.014	0.156	T	T	T	T	T	T	-0.361	0.232	0.771	N	N	-1.417	0.110	-1.491	0.111	0.000	0.554	0.590	0.602	0.542	.	3.620	-3.520	-1.285	-0.712	-0.194	0.000	0.001	0.127	603	.	.	.	.	KIAA1257	293	0	366	28	0.0710659898477157	TRUE	TRUE
ENSG00000152592.14	.	BCM	GRCh38.p13	chr4	87663306	87663306	+	C	C	A	Missense_Mutation	SNP	ENST00000339673.11	exon6	c.C1528A	p.Q510K	exonic	ENSG00000152592.14	.	nonsynonymous SNV	ENSG00000152592.14:ENST00000339673.11:exon6:c.C1528A:p.Q510K	4q22.1	C3N-03173	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	D	D	M	T	N	0.843	T	T	D	0.271	0.545	0.919	0.065	T	T	D	D	D	D	3.503	24.700	0.985	D	D	0.675	6.781	0.658	7.036	0.998	0.487	0.574	0.574	0.542	.	5.900	5.900	5.025	1.026	0.599	1.000	0.987	0.675	419	.	.	.	ID=COSV99218567;OCCURENCE=1(endometrium)	DMP1	366	0	315	23	0.0680473372781065	TRUE	TRUE
ENSG00000172403.11	.	BCM	GRCh38.p13	chr4	119023433	119023433	+	C	C	T	Nonsense_Mutation	SNP	ENST00000429713.7	exon2	c.C109T	p.R37X	exonic	ENSG00000172403.11	.	stopgain	ENSG00000172403.11:ENST00000429713.7:exon2:c.C109T:p.R37X	4q26	C3N-03173	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.925	.	.	.	.	.	.	.	.	.	D	D	.	.	6.648	36	0.998	D	N	0.724	7.473	0.593	6.132	1.000	0.554	0.574	0.602	0.613	.	5.660	4.810	3.126	1.026	0.599	1.000	0.998	0.996	576	PDZ_domain	.	.	ID=COSV61110482;OCCURENCE=3(large_intestine),1(skin),1(thyroid),2(endometrium)	SYNPO2	77	0	52	4	0.0714285714285714	NA	TRUE
ENSG00000113504.21	.	BCM	GRCh38.p13	chr5	1052373	1052373	+	G	G	T	Missense_Mutation	SNP	ENST00000264930.10	exon24	c.C3239A	p.T1080N	exonic	ENSG00000113504.21	.	nonsynonymous SNV	ENSG00000113504.21:ENST00000264930.10:exon24:c.C3239A:p.T1080N	5p15.33	C3N-03173	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.886	D	D	D	0.594	0.501	0.858	1.110	T	D	D	D	D	D	3.880	26.200	0.995	D	D	0.842	9.664	0.719	8.123	1.000	0.707	0.709	0.723	0.714	.	3.880	3.880	9.092	1.028	0.618	1.000	1.000	0.996	976	SLC12A_transporter,_C-terminal	.	.	.	SLC12A7	234	1	261	27	0.09375	TRUE	TRUE
ENSG00000146352.13	.	BCM	GRCh38.p13	chr6	122997985	122997985	+	C	C	T	Missense_Mutation	SNP	ENST00000275162.10	exon2	c.C208T	p.R70C	exonic	ENSG00000146352.13	.	nonsynonymous SNV	ENSG00000146352.13:ENST00000275162.10:exon2:c.C208T:p.R70C	6q22.31	C3N-03173	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.642	D	D	D	0.604	0.539	0.865	1.854	D	D	D	D	D	D	4.169	28.400	0.999	D	D	0.655	6.529	0.653	6.957	1.000	0.583	0.563	0.615	0.530	.	5.390	5.390	2.566	1.026	0.549	1.000	1.000	0.999	839	CRAL/TRIO,_N-terminal_domain	.	.	.	CLVS2	323	0	275	18	0.0614334470989761	TRUE	NA
ENSG00000188730.5	.	BCM	GRCh38.p13	chr7	49775692	49775692	+	G	G	A	Missense_Mutation	SNP	ENST00000340652.5	exon2	c.G257A	p.G86D	exonic	ENSG00000188730.5	.	nonsynonymous SNV	ENSG00000188730.5:ENST00000340652.5:exon2:c.G257A:p.G86D	7p12.2	C3N-03173	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	T	N	0.121	T	T	D	0.086	0.097	0.458	1.281	D	T	T	T	T	T	2.482	22.400	0.983	N	N	-0.594	0.999	-0.493	1.213	0.955	0.598	0.596	0.607	0.639	.	4.920	2.780	1.474	1.009	0.588	0.787	0.680	0.145	954	.	.	.	.	VWC2	211	0	169	24	0.124352331606218	TRUE	TRUE
ENSG00000146955.11	.	BCM	GRCh38.p13	chr7	140407726	140407726	+	A	A	G	Missense_Mutation	SNP	ENST00000537763.6	exon2	c.A80G	p.N27S	exonic	ENSG00000146955.11	.	nonsynonymous SNV	ENSG00000146955.11:ENST00000537763.6:exon2:c.A80G:p.N27S	7q34	C3N-03173	3.295e-05	0	0	0.0001	0	4.495e-05	0	0	rs367821693	7.20	T	T	P	P	D	D	N	D	N	0.513	T	T	D	0.338	.	0.547	0.542	T	T	T	T	T	D	2.710	22.800	0.999	D	D	0.210	3.350	0.304	3.740	1.000	0.706	0.588	0.710	0.564	.	5.950	4.760	5.308	1.312	0.756	1.000	0.998	0.998	672	Small_GTP-binding_protein_domain	.	.	.	RAB19	342	0	352	37	0.0951156812339332	TRUE	NA
ENSG00000055118.15	.	BCM	GRCh38.p13	chr7	150958110	150958110	+	C	C	T	Missense_Mutation	SNP	ENST00000262186.10	exon4	c.G865A	p.E289K	exonic	ENSG00000055118.15	.	nonsynonymous SNV	ENSG00000055118.15:ENST00000262186.10:exon4:c.G865A:p.E289K	7q36.1	C3N-03173	.	.	.	.	.	.	.	.	rs199472880	12.20	T	T	B	B	D	D	N	D	N	0.520	D	D	D	0.694	0.760	1.000	1.171	D	T	D	D	T	D	2.573	22.600	0.998	D	D	-0.078	2.247	0.039	2.497	1.000	0.598	0.590	0.507	0.639	.	3.820	3.820	1.693	0.951	0.524	0.727	0.968	0.807	856	.	.	.	ID=COSV100061559;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	KCNH2	39	0	54	3	0.0526315789473684	TRUE	NA
ENSG00000044459.15	.	BCM	GRCh38.p13	chr9	17342368	17342368	+	C	C	T	Nonsense_Mutation	SNP	ENST00000380647.8	exon12	c.C1810T	p.R604X	exonic	ENSG00000044459.15	.	stopgain	ENSG00000044459.15:ENST00000380647.8:exon12:c.C1810T:p.R604X	9p22.2	C3N-03173	2.491e-05	0.0001	0	0.0001	0	1.502e-05	0	0	rs375104473	4.5	.	.	.	.	.	A	.	.	.	0.051	.	.	.	.	.	.	.	.	.	D	D	.	.	6.727	36	0.998	D	N	0.639	6.347	0.460	4.816	0.721	0.706	0.588	0.710	0.655	.	5.450	4.520	0.269	-0.758	-0.189	0.945	0.350	0.614	593	.	.	.	ID=COSV52080648;OCCURENCE=1(endometrium)	CNTLN	233	0	196	16	0.0754716981132075	TRUE	TRUE
ENSG00000128815.19	.	BCM	GRCh38.p13	chr10	48822446	48822446	+	-	NA	CA	Frame_Shift_Ins	INS	ENST00000325239.11	exon35	c.5891_5892insCA	p.Q1966Pfs*50	exonic	ENSG00000128815.19	.	frameshift insertion	ENSG00000128815.19:ENST00000325239.11:exon35:c.5891_5892insCA:p.Q1966Pfs*50	10q11.23	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WDFY4	NA	NA	NA	NA	NA	NA	NA
ENSG00000107719.9	.	BCM	GRCh38.p13	chr10	70538892	70538892	+	C	C	T	Missense_Mutation	SNP	ENST00000263563.7	exon13	c.C1453T	p.R485W	exonic	ENSG00000107719.9	.	nonsynonymous SNV	ENSG00000107719.9:ENST00000263563.7:exon13:c.C1453T:p.R485W	10q22.1	C3N-03173	8.348e-06	0	0	0	0	1.527e-05	0	0	rs759096960	7.20	D	D	D	P	N	D	L	T	N	0.332	T	T	D	0.138	.	0.582	0.536	T	T	T	T	D	T	2.357	21.900	0.993	D	N	-0.580	1.025	-0.712	0.882	1.000	0.696	0.602	0.723	0.636	.	5.010	-0.032	1.103	-0.159	-0.859	0.882	0.050	0.013	388	.	.	.	.	PALD1	185	0	158	16	0.0919540229885057	TRUE	NA
ENSG00000110497.14	.	BCM	GRCh38.p13	chr11	46545611	46545611	+	G	G	A	Missense_Mutation	SNP	ENST00000458649.6	exon5	c.C544T	p.R182W	exonic	ENSG00000110497.14	.	nonsynonymous SNV	ENSG00000110497.14:ENST00000458649.6:exon5:c.C544T:p.R182W	11p11.2	C3N-03173	8.258e-06	0	0	0	0	1.502e-05	0	0	rs757353536	15.20	D	D	D	D	D	D	L	T	D	0.465	T	T	D	0.344	0.595	0.455	0.649	D	D	T	D	D	D	3.668	25.300	0.997	D	D	0.358	4.093	0.375	4.189	0.882	0.719	0.725	0.723	0.714	.	5.830	3.740	2.938	0.227	-0.182	1.000	0.983	0.685	0	.	.	.	.	AMBRA1	120	0	106	19	0.152	TRUE	NA
ENSG00000176567.1	.	BCM	GRCh38.p13	chr11	48263976	48263976	+	G	G	T	Missense_Mutation	SNP	ENST00000320048.1	exon1	c.G116T	p.G39V	exonic	ENSG00000176567.1	.	nonsynonymous SNV	ENSG00000176567.1:ENST00000320048.1:exon1:c.G116T:p.G39V	11p11.2	C3N-03173	.	.	.	.	.	.	.	.	.	8.19	D	D	D	D	.	N	M	T	D	0.615	T	T	T	0.148	0.823	0.761	0.006	T	T	T	T	D	T	3.042	23.500	0.996	D	N	0.655	6.539	0.482	4.997	0.001	0.487	0.574	0.574	0.564	.	4.150	4.150	2.176	1.126	0.565	0.991	0.803	0.297	120	GPCR,_rhodopsin-like,_7TM	.	.	.	OR4X1	405	0	370	44	0.106280193236715	TRUE	TRUE
ENSG00000133318.14	.	BCM	GRCh38.p13	chr11	63718809	63718809	+	-	NA	A	Frame_Shift_Ins	INS	ENST00000377819.10	exon3	c.308dupA	p.S105Kfs*50	exonic	ENSG00000133318.14	.	frameshift insertion	ENSG00000133318.14:ENST00000377819.10:exon3:c.308dupA:p.S105Kfs*50	11q13.1	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RTN3	NA	NA	NA	NA	NA	NA	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-03173	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	268	0	266	26	0.089041095890411	TRUE	TRUE
ENSG00000167548.15	.	BCM	GRCh38.p13	chr12	49052223	49052223	+	C	C	T	Missense_Mutation	SNP	ENST00000301067.11	exon10	c.G1460A	p.R487Q	exonic	ENSG00000167548.15	.	nonsynonymous SNV	ENSG00000167548.15:ENST00000301067.11:exon10:c.G1460A:p.R487Q	12q13.12	C3N-03173	2.492e-05	0	0	0	0	4.511e-05	0	0	rs778182231	1.18	T	.	B	B	.	N	N	T	N	0.036	T	T	D	0.150	0.245	0.241	0.214	T	T	T	T	T	T	-1.356	0.001	0.455	N	N	-1.330	0.149	-1.384	0.160	0.990	0.707	0.702	0.702	0.714	.	2.630	-1.010	-0.818	-3.396	-4.906	0.000	0.000	0.000	360	.	.	.	.	KMT2D	93	0	90	6	0.0625	TRUE	NA
ENSG00000185640.6	.	BCM	GRCh38.p13	chr12	52830054	52830054	+	T	T	C	Missense_Mutation	SNP	ENST00000330553.6	exon4	c.A824G	p.E275G	exonic	ENSG00000185640.6	.	nonsynonymous SNV	ENSG00000185640.6:ENST00000330553.6:exon4:c.A824G:p.E275G	12q13.13	C3N-03173	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	N	D	H	D	D	0.912	D	D	D	0.788	0.638	0.829	0.491	T	D	D	D	D	T	4.497	32	0.999	D	D	0.786	8.508	0.669	7.208	1.000	0.549	0.627	0.547	0.530	.	4.540	4.540	7.652	1.138	0.665	1.000	0.993	0.994	553	Intermediate_filament,_rod_domain	.	.	.	KRT79	169	1	206	11	0.0506912442396313	TRUE	NA
ENSG00000111450.14	.	BCM	GRCh38.p13	chr12	130798605	130798605	+	C	C	T	Missense_Mutation	SNP	ENST00000392373.7	exon9	c.G706A	p.V236I	exonic	ENSG00000111450.14	.	nonsynonymous SNV	ENSG00000111450.14:ENST00000392373.7:exon9:c.G706A:p.V236I	12q24.33	C3N-03173	.	.	.	.	.	.	.	.	.	5.20	T	T	D	D	N	D	L	T	N	0.284	T	T	T	0.184	0.580	0.806	0.414	T	T	T	T	D	T	1.340	14.670	0.984	D	N	0.009	2.542	-0.092	2.071	1.000	0.732	0.744	0.744	0.728	.	5.010	4.130	3.482	-0.276	-0.935	0.996	0.006	0.022	929	Syntaxin/epimorphin,_conserved_site;Target_SNARE_coiled-coil_homology_domain	.	.	.	STX2	140	0	143	12	0.0774193548387097	TRUE	TRUE
ENSG00000021645.19	.	BCM	GRCh38.p13	chr14	79663901	79663901	+	G	G	A	Missense_Mutation	SNP	ENST00000557594.5	exon3	c.G553A	p.A185T	exonic	ENSG00000021645.19	.	nonsynonymous SNV	ENSG00000021645.19:ENST00000557594.5:exon3:c.G553A:p.A185T	14q31.1	C3N-03173	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	.	T	D	0.847	D	D	D	0.717	0.550	0.887	0.644	D	D	D	D	D	D	4.047	27.300	0.999	D	D	0.744	7.784	0.733	8.421	1.000	0.638	0.588	0.653	0.621	.	5.630	5.630	9.981	1.155	0.654	1.000	0.276	0.535	938	Laminin_G_domain	.	.	.	NRXN3	254	0	247	15	0.0572519083969466	TRUE	TRUE
ENSG00000198901.14	.	BCM	GRCh38.p13	chr15	90981748	90981748	+	-	NA	T	Frame_Shift_Ins	INS	ENST00000394249.8	exon4	c.500dupA	p.A168Gfs*3	exonic	ENSG00000198901.14	.	frameshift insertion	ENSG00000198901.14:ENST00000394249.8:exon4:c.500dupA:p.A168Gfs*3	15q26.1	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRC1	NA	NA	NA	NA	NA	NA	NA
ENSG00000167394.13	.	BCM	GRCh38.p13	chr16	31063900	31063900	+	C	C	T	Missense_Mutation	SNP	ENST00000300849.5	exon2	c.G560A	p.R187Q	exonic	ENSG00000167394.13	.	nonsynonymous SNV	ENSG00000167394.13:ENST00000300849.5:exon2:c.G560A:p.R187Q	16p11.2	C3N-03173	.	.	.	.	.	.	.	.	.	5.16	T	T	.	.	D	D	.	T	N	0.189	T	T	T	0.159	0.389	0.619	1.060	D	.	T	T	T	D	3.187	23.800	0.960	D	N	-0.093	2.197	0.054	2.552	1.000	0.672	0.702	0.723	0.636	.	5.180	5.180	0.696	1.026	0.599	0.993	1.000	0.996	45	Zinc_finger_C2H2-type	.	.	.	ZNF668	166	0	178	11	0.0582010582010582	TRUE	NA
ENSG00000140675.13	.	BCM	GRCh38.p13	chr16	31488745	31488745	+	G	G	A	Missense_Mutation	SNP	ENST00000330498.4	exon10	c.G1253A	p.G418D	exonic	ENSG00000140675.13	.	nonsynonymous SNV	ENSG00000140675.13:ENST00000330498.4:exon10:c.G1253A:p.G418D	16p11.2	C3N-03173	.	.	.	.	.	.	.	.	.	5.20	D	D	B	B	N	N	N	D	N	0.420	T	T	D	0.260	0.486	0.751	0.345	T	T	T	T	T	D	2.118	20.200	0.980	N	N	-0.619	0.953	-0.596	1.052	1.000	0.652	0.551	0.641	0.555	.	4.460	4.460	0.589	0.189	-0.153	0.000	0.005	0.018	310	.	.	.	.	SLC5A2	338	0	304	33	0.0979228486646884	TRUE	TRUE
ENSG00000103034.14	.	BCM	GRCh38.p13	chr16	58507830	58507830	+	C	C	T	Missense_Mutation	SNP	ENST00000570248.5	exon9	c.C643T	p.R215W	exonic	ENSG00000103034.14	.	nonsynonymous SNV	ENSG00000103034.14:ENST00000570248.5:exon9:c.C643T:p.R215W	16q21	C3N-03173	1.662e-05	0	0	0	0	3.03e-05	0	0	rs753085219	15.20	D	D	D	D	D	D	M	T	D	0.835	T	T	D	0.480	.	0.796	0.317	T	T	D	D	D	D	3.995	26.900	0.999	D	D	0.526	5.241	0.426	4.545	1.000	0.707	0.588	0.644	0.714	.	5.590	2.360	1.738	0.096	0.599	1.000	0.997	0.964	895	.	.	.	.	NDRG4	207	0	234	19	0.075098814229249	TRUE	NA
ENSG00000129993.15	.	BCM	GRCh38.p13	chr16	88877025	88877025	+	C	C	T	Missense_Mutation	SNP	ENST00000268679.9	exon12	c.G1913A	p.R638H	exonic	ENSG00000129993.15	.	nonsynonymous SNV	ENSG00000129993.15:ENST00000268679.9:exon12:c.G1913A:p.R638H	16q24.3	C3N-03173	.	.	.	.	.	.	.	.	rs562711336	4.20	D	D	B	B	U	N	L	T	N	0.106	T	T	D	0.057	0.208	0.522	1.189	T	T	T	T	T	D	2.152	20.500	0.991	N	N	-0.492	1.192	-0.491	1.217	0.225	0.635	0.644	0.576	0.563	.	4.620	3.670	1.454	0.994	0.541	0.007	0.540	0.054	819	.	.	.	.	CBFA2T3	76	0	49	7	0.125	TRUE	NA
ENSG00000158805.12	.	BCM	GRCh38.p13	chr16	89723625	89723625	+	G	G	T	Missense_Mutation	SNP	ENST00000443381.7	exon4	c.G922T	p.A308S	exonic	ENSG00000158805.12	.	nonsynonymous SNV	ENSG00000158805.12:ENST00000443381.7:exon4:c.G922T:p.A308S	16q24.3	C3N-03173	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.105	T	T	T	0.039	0.466	0.061	0.069	T	T	T	T	T	T	0.821	9.599	0.937	N	N	-0.570	1.044	-0.618	1.019	1.000	0.677	0.686	0.673	0.628	.	5.660	3.690	0.880	1.146	0.676	0.001	0.035	0.012	698	.	.	.	.	ZNF276	298	0	251	33	0.116197183098592	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674220	7674220	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.G743A	p.R248Q	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.G743A:p.R248Q	17p13.1	C3N-03173	5.768e-05	0	0	0.0002	0	7.493e-05	0	0	rs11540652	19.20	D	D	D	D	D	A	M	D	D	0.946	D	D	D	0.934	.	0.975	0.412	T	D	D	D	D	D	4.282	29.400	0.999	D	D	0.660	6.591	0.561	5.765	0.799	0.722	0.702	0.725	0.735	.	4.620	3.650	6.163	1.021	0.596	1.000	0.981	0.841	433	p53,_DNA-binding_domain	.	.	ID=COSV52661580;OCCURENCE=3(salivary_gland),148(breast),3(penis),1(peritoneum),13(liver),1(genital_tract),73(oesophagus),2(adrenal_gland),1(meninges),4(cervix),277(large_intestine),71(central_nervous_system),10(biliary_tract),3(pleura),11(vulva),57(ovary),8(bone),8(NS),70(stomach),116(haematopoietic_and_lymphoid_tissue),6(soft_tissue),8(kidney),57(urinary_tract),34(pancreas),1(pituitary),23(skin),46(prostate),53(lung),18(thyroid),74(upper_aerodigestive_tract),1(testis),1(eye),1(thymus),11(small_intestine),44(endometrium)	TP53	374	0	314	29	0.0845481049562682	TRUE	TRUE
ENSG00000008838.20	.	BCM	GRCh38.p13	chr17	40035137	40035137	+	A	A	T	Missense_Mutation	SNP	ENST00000394128.7	exon6	c.T539A	p.I180N	exonic	ENSG00000008838.20	.	nonsynonymous SNV	ENSG00000008838.20:ENST00000394128.7:exon6:c.T539A:p.I180N	17q21.1	C3N-03173	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.989	T	T	D	0.501	0.570	0.857	1.733	T	D	D	D	D	D	4.132	28.000	0.943	D	D	0.844	9.692	0.857	12.025	1.000	0.707	0.725	0.672	0.711	.	6.060	6.060	9.279	1.312	0.756	1.000	1.000	0.999	173	Mediator_complex,_subunit_Med24,_N-terminal	.	.	.	MED24	199	0	213	23	0.0974576271186441	TRUE	TRUE
ENSG00000131462.8	.	BCM	GRCh38.p13	chr17	42614323	42614323	+	G	G	A	Missense_Mutation	SNP	ENST00000251413.8	exon9	c.G907A	p.V303M	exonic	ENSG00000131462.8	.	nonsynonymous SNV	ENSG00000131462.8:ENST00000251413.8:exon9:c.G907A:p.V303M	17q21.2	C3N-03173	.	.	.	.	.	.	.	.	.	10.20	T	T	B	B	D	D	N	T	N	0.556	T	T	D	0.434	0.467	0.935	1.597	D	T	D	D	D	D	2.719	22.900	0.805	D	D	-0.449	1.280	-0.175	1.846	1.000	0.707	0.702	0.725	0.714	.	4.250	4.250	9.698	1.151	0.676	1.000	0.993	0.994	338	Tubulin/FtsZ,_2-layer_sandwich_domain	.	.	.	TUBG1	258	0	251	30	0.106761565836299	NA	TRUE
ENSG00000186185.14	.	BCM	GRCh38.p13	chr17	44935315	44935315	+	G	G	A	Missense_Mutation	SNP	ENST00000593135.6	exon3	c.C415T	p.R139C	exonic	ENSG00000186185.14	.	nonsynonymous SNV	ENSG00000186185.14:ENST00000593135.6:exon3:c.C415T:p.R139C	17q21.31	C3N-03173	2.55e-05	0.0001	0	0	0	3.067e-05	0	0	rs781011969	6.18	.	D	P	B	N	N	M	T	.	0.699	T	T	D	0.470	0.685	0.743	0.973	T	T	T	T	D	D	2.256	21.300	0.997	D	N	0.069	2.765	0.025	2.446	0.435	0.707	0.702	0.702	0.714	.	5.500	4.530	1.580	1.176	0.676	0.109	0.715	0.372	739	Kinesin_motor_domain	.	.	ID=COSV59271080;OCCURENCE=1(large_intestine),1(central_nervous_system),1(soft_tissue),2(prostate)	KIF18B	134	0	134	16	0.106666666666667	TRUE	TRUE
ENSG00000187775.17	.	BCM	GRCh38.p13	chr17	78494756	78494756	+	C	C	T	Missense_Mutation	SNP	ENST00000389840.7	exon40	c.G6107A	p.R2036K	exonic	ENSG00000187775.17	.	nonsynonymous SNV	ENSG00000187775.17:ENST00000389840.7:exon40:c.G6107A:p.R2036K	17q25.3	C3N-03173	.	.	.	.	.	.	.	.	.	7.12	.	.	.	.	.	D	.	T	.	0.756	T	T	D	0.243	.	0.181	.	D	.	T	T	D	D	3.775	25.700	0.998	D	D	0.534	5.310	0.505	5.203	1.000	0.635	0.644	0.479	0.634	.	4.120	4.120	7.677	1.010	0.580	1.000	0.944	0.876	908	Dynein_heavy_chain,_hydrolytic_ATP-binding_dynein_motor_region_D1	.	.	.	DNAH17	116	0	123	9	0.0681818181818182	TRUE	TRUE
ENSG00000101361.17	.	BCM	GRCh38.p13	chr20	2655670	2655670	+	G	G	A	Missense_Mutation	SNP	ENST00000329276.10	exon7	c.G833A	p.R278H	exonic	ENSG00000101361.17	.	nonsynonymous SNV	ENSG00000101361.17:ENST00000329276.10:exon7:c.G833A:p.R278H	20p13	C3N-03173	2.471e-05	0	0	0	0	4.495e-05	0	0	rs747781902	18.20	D	D	D	D	D	D	H	T	D	0.953	D	D	D	0.842	0.791	0.867	0.821	T	D	D	D	D	D	4.461	32	0.999	D	D	1.107	17.814	0.978	17.571	1.000	0.722	0.672	0.696	0.735	.	4.900	4.900	9.366	1.176	0.676	1.000	1.000	0.999	764	Nop_domain	.	.	ID=COSV61388773;OCCURENCE=1(upper_aerodigestive_tract)	NOP56	288	1	265	23	0.0798611111111111	TRUE	TRUE
ENSG00000196839.13	.	BCM	GRCh38.p13	chr20	44629108	44629108	+	C	C	G	Missense_Mutation	SNP	ENST00000372874.9	exon3	c.G157C	p.D53H	exonic	ENSG00000196839.13	.	nonsynonymous SNV	ENSG00000196839.13:ENST00000372874.9:exon3:c.G157C:p.D53H	20q13.12	C3N-03173	.	.	.	.	.	.	.	.	.	10.20	T	T	B	B	N	D	L	D	N	0.394	D	D	D	0.361	0.286	0.910	0.179	T	D	D	D	T	D	1.913	18.590	0.918	D	N	-0.145	2.037	0.016	2.415	1.000	0.706	0.702	0.693	0.613	.	5.840	5.840	0.348	1.026	0.599	0.989	0.992	0.310	464	Adenosine/AMP_deaminase_domain	.	.	ID=COSV100866645;OCCURENCE=1(skin)	ADA	426	1	415	37	0.081858407079646	TRUE	TRUE
ENSG00000130940.15	.	BCM	GRCh38.p13	chr1	10639380	10639380	+	G	G	T	Silent	SNP	ENST00000377022.8	exon21	c.C4842A	p.I1614I	exonic	ENSG00000130940.15	.	synonymous SNV	ENSG00000130940.15:ENST00000377022.8:exon21:c.C4842A:p.I1614I	1p36.22	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CASZ1	151	0	170	12	0.0659340659340659	TRUE	TRUE
ENSG00000135931.17	.	BCM	GRCh38.p13	chr2	231370037	231370037	+	G	G	A	Silent	SNP	ENST00000611582.4	exon23	c.G2346A	p.A782A	exonic	ENSG00000135931.17	.	synonymous SNV	ENSG00000135931.17:ENST00000611582.4:exon23:c.G2346A:p.A782A	2q37.1	C3N-03173	.	.	.	.	.	.	.	.	rs771908313	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV72187859;OCCURENCE=2(pancreas)	ARMC9	105	0	98	7	0.0666666666666667	TRUE	NA
ENSG00000132321.17	.	BCM	GRCh38.p13	chr2	236368210	236368210	+	G	G	A	Silent	SNP	ENST00000409907.8	exon14	c.C1653T	p.Y551Y	exonic	ENSG00000132321.17	.	synonymous SNV	ENSG00000132321.17:ENST00000409907.8:exon14:c.C1653T:p.Y551Y	2q37.2	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54508271;OCCURENCE=1(large_intestine)	IQCA1	321	1	312	37	0.106017191977077	TRUE	TRUE
ENSG00000164082.15	.	BCM	GRCh38.p13	chr3	51712517	51712517	+	C	C	T	Silent	SNP	ENST00000395052.8	exon3	c.C495T	p.Y165Y	exonic	ENSG00000164082.15	.	synonymous SNV	ENSG00000164082.15:ENST00000395052.8:exon3:c.C495T:p.Y165Y	3p21.2	C3N-03173	0.0004	0	8.639e-05	0.0008	0.0006	0.0004	0	0.0004	rs200050063	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56585222;OCCURENCE=1(oesophagus),3(central_nervous_system)	GRM2	151	0	109	15	0.120967741935484	TRUE	TRUE
ENSG00000165868.15	.	BCM	GRCh38.p13	chr10	116674820	116674820	+	C	C	T	Silent	SNP	ENST00000369209.7	exon12	c.G1989A	p.S663S	exonic	ENSG00000165868.15	.	synonymous SNV	ENSG00000165868.15:ENST00000369209.7:exon12:c.G1989A:p.S663S	10q25.3	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65021664;OCCURENCE=1(large_intestine),2(endometrium)	HSPA12A	180	0	129	10	0.0719424460431655	TRUE	TRUE
ENSG00000182022.18	.	BCM	GRCh38.p13	chr10	124012376	124012376	+	G	G	A	Silent	SNP	ENST00000435907.6	exon7	c.C1452T	p.N484N	exonic	ENSG00000182022.18	.	synonymous SNV	ENSG00000182022.18:ENST00000435907.6:exon7:c.C1452T:p.N484N	10q26.13	C3N-03173	2.481e-05	0	0	0	0	1.503e-05	0	0.0001	rs767431529	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHST15	111	0	109	10	0.0840336134453782	TRUE	NA
ENSG00000130037.5	.	BCM	GRCh38.p13	chr12	5045554	5045554	+	C	C	T	Silent	SNP	ENST00000252321.5	exon1	c.C1407T	p.D469D	exonic	ENSG00000130037.5	.	synonymous SNV	ENSG00000130037.5:ENST00000252321.5:exon1:c.C1407T:p.D469D	12p13.32	C3N-03173	8.237e-06	0	0	0.0001	0	0	0	0	rs768740011	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52907745;OCCURENCE=1(biliary_tract),1(pancreas),1(skin)	KCNA5	430	0	445	40	0.0824742268041237	TRUE	TRUE
ENSG00000136044.12	.	BCM	GRCh38.p13	chr12	105174389	105174389	+	A	A	G	Silent	SNP	ENST00000258530.8	exon21	c.T1920C	p.Y640Y	exonic	ENSG00000136044.12	.	synonymous SNV	ENSG00000136044.12:ENST00000258530.8:exon21:c.T1920C:p.Y640Y	12q23.3	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	APPL2	137	0	142	8	0.0533333333333333	TRUE	NA
ENSG00000110931.19	.	BCM	GRCh38.p13	chr12	121244588	121244588	+	G	G	A	Silent	SNP	ENST00000404169.8	exon16	c.C1581T	p.S527S	exonic	ENSG00000110931.19	.	synonymous SNV	ENSG00000110931.19:ENST00000404169.8:exon16:c.C1581T:p.S527S	12q24.31	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61216837;OCCURENCE=1(skin)	CAMKK2	113	0	121	13	0.0970149253731343	TRUE	TRUE
ENSG00000102452.17	.	BCM	GRCh38.p13	chr13	101065457	101065457	+	G	G	A	Silent	SNP	ENST00000251127.11	exon40	c.C4551T	p.Y1517Y	exonic	ENSG00000102452.17	.	synonymous SNV	ENSG00000102452.17:ENST00000251127.11:exon40:c.C4551T:p.Y1517Y	13q32.3	C3N-03173	1.647e-05	0	8.637e-05	0	0	0	0	6.056e-05	rs748173874	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51929902;OCCURENCE=1(large_intestine),1(soft_tissue),1(endometrium)	NALCN	200	0	213	24	0.10126582278481	TRUE	TRUE
ENSG00000150394.14	.	BCM	GRCh38.p13	chr16	61817622	61817622	+	G	G	T	Silent	SNP	ENST00000577390.6	exon7	c.C1134A	p.V378V	exonic	ENSG00000150394.14	.	synonymous SNV	ENSG00000150394.14:ENST00000577390.6:exon7:c.C1134A:p.V378V	16q21	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDH8	153	0	155	9	0.0548780487804878	TRUE	TRUE
ENSG00000103335.22	.	BCM	GRCh38.p13	chr16	88722906	88722906	+	G	G	T	Silent	SNP	ENST00000301015.14	exon34	c.C4599A	p.T1533T	exonic	ENSG00000103335.22	.	synonymous SNV	ENSG00000103335.22:ENST00000301015.14:exon34:c.C4599A:p.T1533T	16q24.3	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PIEZO1	331	1	365	22	0.0568475452196382	TRUE	TRUE
ENSG00000160602.14	.	BCM	GRCh38.p13	chr17	28737491	28737491	+	C	C	T	Silent	SNP	ENST00000268766.11	exon5	c.C804T	p.D268D	exonic	ENSG00000160602.14	.	synonymous SNV	ENSG00000160602.14:ENST00000268766.11:exon5:c.C804T:p.D268D	17q11.2	C3N-03173	5.825e-05	0	0	0	0	0	0	0.0004	rs748341861	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEK8	227	0	146	15	0.093167701863354	TRUE	NA
ENSG00000174586.11	.	BCM	GRCh38.p13	chr19	58357123	58357123	+	G	G	A	Silent	SNP	ENST00000311044.8	exon3	c.C513T	p.F171F	exonic	ENSG00000174586.11	.	synonymous SNV	ENSG00000174586.11:ENST00000311044.8:exon3:c.C513T:p.F171F	19q13.43	C3N-03173	8.638e-06	0	0	0	0	1.576e-05	0	0	rs777005764	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF497	352	0	338	23	0.0637119113573407	TRUE	NA
ENSG00000269855.2	.	BCM	GRCh38.p13	chr19	58396860	58396860	+	C	C	A	Silent	SNP	ENST00000601382.2	exon1	c.C771A	p.P257P	exonic	ENSG00000269855.2	.	synonymous SNV	ENSG00000269855.2:ENST00000601382.2:exon1:c.C771A:p.P257P	19q13.43	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF225	409	0	445	36	0.0748440748440748	TRUE	TRUE
ENSG00000152061.23	.	BCM	GRCh38.p13	chr1	174547863	174547863	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000152061.23	.	.	.	1q25.1	C3N-03173	0.0002	0	0.0034	0	0	0.0002	0	0.0001	rs541353580	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RABGAP1L	128	0	140	10	0.0666666666666667	TRUE	NA
ENSG00000181215.15	.	BCM	GRCh38.p13	chr4	5989378	5989378	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000181215.15	ENST00000324058.9:c.-1029G>A	.	.	4p16.2	C3N-03173	.	.	.	.	.	.	.	.	.	0.9	.	.	.	.	.	N	.	.	.	.	T	T	T	0.004	.	0.061	0.026	.	.	T	T	T	T	-1.276	0.002	0.399	N	.	-1.824	0.021	-2.090	0.009	1.000	0.497	0.590	0.547	0.613	.	3.890	-7.780	-3.003	-1.105	-1.910	0.000	0.000	0.000	988	.	.	.	.	C4orf50	189	0	138	10	0.0675675675675676	TRUE	TRUE
ENSG00000236529.2	.	BCM	GRCh38.p13	chr7	65840538	65840538	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000236529.2	.	.	.	7q11.21	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC093582.1	191	0	156	9	0.0545454545454545	TRUE	NA
ENSG00000272634.2	.	BCM	GRCh38.p13	chr11	4709992	4709992	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000272634.2	.	.	.	11p15.4	C3N-03173	0.0011	0	0	0	0	0	0	0.0021	rs778082350	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR51F5P	245	1	195	22	0.101382488479263	TRUE	NA
ENSG00000188986.8	.	BCM	GRCh38.p13	chr9	137255985	137255987	+	TTC	TTC	GTA	Unknown	MNP	ENST00000343053.5	exon2	c.325_327delinsGTA	p.F109V	exonic	ENSG00000188986.8	.	nonframeshift substitution	ENSG00000188986.8:ENST00000343053.5:exon2:c.325_327delinsGTA:p.F109V	9q34.3	C3N-03173	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NELFB	226	10	192	10	0.0495049504950495	TRUE	NA
ENSG00000130764.10	.	BCM	GRCh38.p13	chr1	3786876	3786876	+	A	A	T	Missense_Mutation	SNP	ENST00000378251.3	exon2	c.T1050A	p.N350K	exonic	ENSG00000130764.10	.	nonsynonymous SNV	ENSG00000130764.10:ENST00000378251.3:exon2:c.T1050A:p.N350K	1p36.32	C3L-04475	.	.	.	.	.	.	.	.	.	8.20	D	D	P	P	D	D	L	T	D	0.648	T	T	D	0.240	0.719	0.425	0.980	T	T	T	T	D	D	1.444	15.370	0.982	N	N	-0.859	0.574	-1.085	0.391	0.996	0.707	0.702	0.702	0.714	.	5.220	-6.200	-0.290	-0.137	-0.210	0.079	0.012	0.161	946	B3/B4_tRNA-binding_domain	.	.	.	LRRC47	158	0	207	32	0.133891213389121	TRUE	TRUE
ENSG00000169174.11	.	BCM	GRCh38.p13	chr1	55056101	55056101	+	G	G	A	Missense_Mutation	SNP	ENST00000302118.5	exon6	c.G908A	p.R303H	exonic	ENSG00000169174.11	.	nonsynonymous SNV	ENSG00000169174.11:ENST00000302118.5:exon6:c.G908A:p.R303H	1p32.3	C3L-04475	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	M	D	N	0.076	T	T	T	0.173	0.649	0.448	0.281	T	T	T	T	T	T	0.873	10.150	0.978	N	N	-1.232	0.205	-1.334	0.188	1.000	0.696	0.590	0.723	0.613	.	3.880	-6.580	-0.085	-0.488	-0.106	0.000	0.056	0.955	872	Peptidase_S8/S53_domain;Proteinase_K-like_catalytic_domain	.	.	ID=COSV100135399;OCCURENCE=1(endometrium)	PCSK9	58	0	118	21	0.151079136690647	TRUE	TRUE
ENSG00000031698.13	.	BCM	GRCh38.p13	chr1	109236400	109236400	+	A	A	G	Missense_Mutation	SNP	ENST00000234677.7	exon9	c.A1109G	p.N370S	exonic	ENSG00000031698.13	.	nonsynonymous SNV	ENSG00000031698.13:ENST00000234677.7:exon9:c.A1109G:p.N370S	1p13.3	C3L-04475	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.659	T	T	D	0.482	0.720	0.804	2.237	D	D	T	T	D	D	4.100	27.800	0.999	D	D	0.830	9.397	0.845	11.576	1.000	0.707	0.725	0.725	0.714	.	6.080	6.080	9.014	1.298	0.754	1.000	1.000	0.998	718	Aminoacyl-tRNA_synthetase,_class_II;Aminoacyl-tRNA_synthetase,_class_II_(G/_P/_S/T);Serine-tRNA_ligase_catalytic_core_domain	.	.	.	SARS1	92	0	138	14	0.0921052631578947	TRUE	NA
ENSG00000163354.15	.	BCM	GRCh38.p13	chr1	155030167	155030167	+	C	C	T	Missense_Mutation	SNP	ENST00000368424.4	exon7	c.G1094A	p.R365H	exonic	ENSG00000163354.15	.	nonsynonymous SNV	ENSG00000163354.15:ENST00000368424.4:exon7:c.G1094A:p.R365H	1q21.3	C3L-04475	2.475e-05	0	8.643e-05	0.0001	0	0	0	6.057e-05	rs200847364	0.20	T	T	B	B	N	N	N	T	N	0.152	T	T	T	0.083	.	0.277	0.091	T	T	T	T	T	T	0.187	2.973	0.925	N	N	-1.588	0.058	-1.626	0.068	0.892	0.516	0.610	0.576	0.613	.	4.830	-7.510	-2.672	-0.667	-0.202	0.000	0.803	0.664	258	Dendritic_cell-specific_transmembrane_protein-like	.	.	ID=COSV55051586;OCCURENCE=2(thyroid),1(endometrium)	DCST2	454	0	506	63	0.110720562390158	TRUE	TRUE
ENSG00000018699.13	.	BCM	GRCh38.p13	chr2	32758430	32758430	+	C	C	T	Missense_Mutation	SNP	ENST00000317907.9	exon13	c.C1591T	p.R531C	exonic	ENSG00000018699.13	.	nonsynonymous SNV	ENSG00000018699.13:ENST00000317907.9:exon13:c.C1591T:p.R531C	2p22.3	C3L-04475	1.647e-05	0	0	0	0	1.498e-05	0	6.056e-05	rs751228170	17.20	D	D	D	D	D	D	M	T	D	0.875	D	T	D	0.508	0.574	0.895	0.323	T	D	D	D	D	D	4.269	29.300	0.999	D	D	0.880	10.545	0.835	11.254	1.000	0.719	0.725	0.725	0.734	.	5.860	5.860	6.036	1.026	0.599	1.000	0.943	0.880	168	Tetratricopeptide_repeat-containing_domain	.	.	.	TTC27	554	0	676	56	0.0765027322404372	TRUE	NA
ENSG00000135632.12	.	BCM	GRCh38.p13	chr2	73218918	73218918	+	C	C	T	Missense_Mutation	SNP	ENST00000389501.9	exon2	c.C154T	p.R52W	exonic	ENSG00000135632.12	.	nonsynonymous SNV	ENSG00000135632.12:ENST00000389501.9:exon2:c.C154T:p.R52W	2p13.2	C3L-04475	4.97e-05	0	0	0.0002	0	5.996e-05	0	0	rs373347931	12.20	D	D	D	D	N	N	L	D	D	0.654	T	D	D	0.377	.	0.930	1.080	T	T	T	T	D	D	3.882	26.200	0.999	D	D	0.464	4.771	0.419	4.496	1.000	0.706	0.710	0.710	0.714	.	5.470	3.470	1.522	0.074	0.599	1.000	0.982	0.989	607	SET_domain	.	.	ID=COSV50264550;OCCURENCE=3(large_intestine),2(stomach)	SMYD5	277	0	380	41	0.0973871733966746	TRUE	TRUE
ENSG00000204640.1	.	BCM	GRCh38.p13	chr2	100470502	100470502	+	G	G	A	Missense_Mutation	SNP	ENST00000376865.1	exon1	c.G14A	p.R5H	exonic	ENSG00000204640.1	.	nonsynonymous SNV	ENSG00000204640.1:ENST00000376865.1:exon1:c.G14A:p.R5H	2q11.2	C3L-04475	1.647e-05	0	8.637e-05	0.0001	0	0	0	0	rs183314287	1.20	D	T	B	B	N	N	N	T	N	0.046	T	T	T	0.021	.	0.088	0.055	T	T	T	T	T	T	-0.324	0.277	0.416	N	N	-1.541	0.069	-1.535	0.095	0.000	0.447	0.547	0.547	0.530	.	4.330	-2.070	-0.436	-0.146	-0.797	0.000	0.001	0.002	618	.	.	.	ID=COSV65259014;OCCURENCE=1(skin)	NMS	251	0	341	31	0.0833333333333333	TRUE	TRUE
ENSG00000169629.12	.	BCM	GRCh38.p13	chr2	112399712	112399712	+	C	C	A	Missense_Mutation	SNP	ENST00000302558.8	exon14	c.G1975T	p.A659S	exonic	ENSG00000169629.12	.	nonsynonymous SNV	ENSG00000169629.12:ENST00000302558.8:exon14:c.G1975T:p.A659S	2q14.1	C3L-04475	.	.	.	.	.	.	.	.	.	2.19	T	T	P	P	.	N	M	T	N	0.201	T	T	T	0.072	0.377	0.654	.	T	T	T	T	T	T	1.862	18.190	0.957	D	N	-0.162	1.985	-0.204	1.775	0.000	0.693	0.659	0.653	0.668	.	2.350	2.350	4.041	0.906	0.284	1.000	0.991	0.707	917	.	.	.	.	RGPD8	385	1	349	47	0.118686868686869	NA	TRUE
ENSG00000178149.17	.	BCM	GRCh38.p13	chr3	49018545	49018545	+	C	C	A	Missense_Mutation	SNP	ENST00000341949.9	exon1	c.G20T	p.G7V	exonic	ENSG00000178149.17	.	nonsynonymous SNV	ENSG00000178149.17:ENST00000341949.9:exon1:c.G20T:p.G7V	3p21.31	C3L-04475	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	M	T	D	0.646	T	T	D	0.331	0.505	0.765	2.241	T	T	T	T	D	T	3.158	23.800	0.995	N	N	0.284	3.696	0.152	2.958	1.000	0.468	0.504	0.474	0.373	.	4.580	4.580	1.764	0.936	0.587	0.153	0.095	0.074	0	.	.	.	.	DALRD3	166	0	198	27	0.12	TRUE	TRUE
ENSG00000013293.6	.	BCM	GRCh38.p13	chr3	170486314	170486314	+	C	C	T	Missense_Mutation	SNP	ENST00000231706.6	exon5	c.G814A	p.A272T	exonic	ENSG00000013293.6	.	nonsynonymous SNV	ENSG00000013293.6:ENST00000231706.6:exon5:c.G814A:p.A272T	3q26.2	C3L-04475	8.238e-06	0	0	0	0	1.499e-05	0	0	rs774948709	20.20	D	D	D	D	D	D	M	D	D	0.952	D	D	D	0.761	.	0.784	0.615	D	D	D	D	D	D	3.801	25.800	0.999	D	D	0.725	7.476	0.705	7.847	1.000	0.554	0.590	0.547	0.568	.	5.950	5.080	7.510	0.966	0.530	1.000	0.996	0.938	828	.	.	.	ID=COSV99200507;OCCURENCE=1(endometrium)	SLC7A14	210	1	351	30	0.078740157480315	TRUE	NA
ENSG00000186038.9	.	BCM	GRCh38.p13	chr3	184105769	184105769	+	C	C	G	Missense_Mutation	SNP	ENST00000415389.6	exon7	c.C725G	p.A242G	exonic	ENSG00000186038.9	.	nonsynonymous SNV	ENSG00000186038.9:ENST00000415389.6:exon7:c.C725G:p.A242G	3q27.1	C3L-04475	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	U	N	M	T	D	0.434	T	D	T	0.388	0.429	0.918	0.136	T	T	T	T	D	T	3.469	24.600	0.997	D	D	0.554	5.489	0.477	4.956	0.807	0.487	0.547	0.573	0.564	.	3.670	3.670	3.684	0.874	0.526	1.000	0.996	0.986	671	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	.	HTR3E	223	1	285	47	0.141566265060241	TRUE	TRUE
ENSG00000145241.11	.	BCM	GRCh38.p13	chr4	67508859	67508859	+	C	C	T	Missense_Mutation	SNP	ENST00000273853.11	exon10	c.G1859A	p.S620N	exonic	ENSG00000145241.11	.	nonsynonymous SNV	ENSG00000145241.11:ENST00000273853.11:exon10:c.G1859A:p.S620N	4q13.2	C3L-04475	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	L	.	N	0.021	T	T	T	0.010	0.164	0.356	0.040	T	T	T	T	T	T	-0.886	0.015	0.337	N	N	-1.276	0.178	-1.348	0.179	0.034	0.707	0.725	0.651	0.714	.	5.100	-3.270	-1.025	-1.497	-0.208	0.000	0.001	0.019	889	.	.	.	.	CENPC	193	0	200	28	0.12280701754386	NA	TRUE
ENSG00000081051.8	.	BCM	GRCh38.p13	chr4	73442363	73442363	+	C	C	-	Frame_Shift_Del	DEL	ENST00000395792.7	exon5	c.550delC	p.R184Afs*5	exonic	ENSG00000081051.8	.	frameshift deletion	ENSG00000081051.8:ENST00000395792.7:exon5:c.550delC:p.R184Afs*5	4q13.3	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AFP	269	0	303	41	0.119186046511628	TRUE	TRUE
ENSG00000164588.8	.	BCM	GRCh38.p13	chr5	45696086	45696086	+	C	C	A	Missense_Mutation	SNP	ENST00000303230.6	exon1	c.G8T	p.G3V	exonic	ENSG00000164588.8	.	nonsynonymous SNV	ENSG00000164588.8:ENST00000303230.6:exon1:c.G8T:p.G3V	5p12	C3L-04475	.	.	.	.	.	.	.	.	.	7.20	D	D	B	B	N	D	N	D	N	0.214	D	D	D	0.280	0.189	0.513	3.010	T	T	T	T	T	T	2.054	19.660	0.991	N	N	-0.957	0.451	-0.970	0.528	0.662	0.658	0.574	0.619	0.563	.	3.170	1.240	0.145	-0.376	-0.302	0.019	0.855	0.002	486	.	.	.	.	HCN1	106	0	190	23	0.107981220657277	TRUE	TRUE
ENSG00000197208.6	.	BCM	GRCh38.p13	chr5	132313636	132313636	+	T	T	C	Missense_Mutation	SNP	ENST00000200652.4	exon3	c.T520C	p.F174L	exonic	ENSG00000197208.6	.	nonsynonymous SNV	ENSG00000197208.6:ENST00000200652.4:exon3:c.T520C:p.F174L	5q31.1	C3L-04475	.	.	.	.	.	.	.	.	.	11.20	D	T	P	P	D	D	L	T	D	0.813	T	T	D	0.640	0.493	0.852	0.380	T	T	D	D	D	D	3.995	26.900	0.999	D	D	0.455	4.708	0.493	5.097	1.000	0.615	0.590	0.547	0.655	.	5.650	5.650	7.674	1.109	0.665	1.000	0.988	0.939	311	Major_facilitator_superfamily_domain;Sugar_transporter,_conserved_site	.	.	.	SLC22A4	497	0	550	64	0.104234527687296	TRUE	TRUE
ENSG00000145949.11	.	BCM	GRCh38.p13	chr6	2685360	2685360	+	C	C	T	Missense_Mutation	SNP	ENST00000274643.9	exon6	c.G481A	p.A161T	exonic	ENSG00000145949.11	.	nonsynonymous SNV	ENSG00000145949.11:ENST00000274643.9:exon6:c.G481A:p.A161T	6p25.2	C3L-04475	1.647e-05	0	0	0.0002	0	0	0	0	rs780360412	2.20	T	T	P	B	N	N	N	T	N	0.307	T	T	T	0.079	0.451	0.421	0.161	T	T	T	T	T	D	2.153	20.500	0.999	D	N	0.217	3.379	0.341	3.963	1.000	0.554	0.574	0.618	0.568	.	5.630	5.630	5.043	1.010	0.580	1.000	0.036	0.069	854	Protein_kinase_domain	.	.	.	MYLK4	173	1	228	28	0.109375	TRUE	NA
ENSG00000164603.12	.	BCM	GRCh38.p13	chr7	112915324	112915324	+	C	C	T	Missense_Mutation	SNP	ENST00000297145.9	exon2	c.G284A	p.R95H	exonic	ENSG00000164603.12	.	nonsynonymous SNV	ENSG00000164603.12:ENST00000297145.9:exon2:c.G284A:p.R95H	7q31.1	C3L-04475	8.3e-06	0.0001	0	0	0	0	0	0	rs376187358	16.17	D	D	D	D	D	D	.	.	D	0.903	D	D	D	0.874	.	0.556	2.079	.	T	D	D	D	D	4.183	28.500	0.999	D	D	0.886	10.697	0.854	11.925	1.000	0.651	0.709	0.609	0.636	.	5.510	5.510	7.477	1.008	0.549	1.000	1.000	0.998	863	.	.	.	ID=COSV51776912;OCCURENCE=1(stomach),1(endometrium)	BMT2	110	0	177	26	0.12807881773399	TRUE	TRUE
ENSG00000064419.13	.	BCM	GRCh38.p13	chr7	128972572	128972572	+	G	G	A	Missense_Mutation	SNP	ENST00000265388.9	exon19	c.C2284T	p.R762C	exonic	ENSG00000064419.13	.	nonsynonymous SNV	ENSG00000064419.13:ENST00000265388.9:exon19:c.C2284T:p.R762C	7q32.1	C3L-04475	.	.	.	.	.	.	.	.	rs964315128	13.20	D	T	P	B	D	D	M	T	D	0.909	T	T	D	0.523	0.606	0.668	0.994	D	T	D	D	D	D	3.458	24.600	0.997	D	D	0.355	4.076	0.470	4.901	0.958	0.707	0.725	0.702	0.714	.	5.410	5.410	6.305	1.176	0.676	1.000	1.000	0.999	507	.	.	.	.	TNPO3	117	0	142	23	0.139393939393939	TRUE	NA
ENSG00000104722.14	.	BCM	GRCh38.p13	chr8	24914238	24914238	+	G	G	A	Missense_Mutation	SNP	ENST00000221166.10	exon1	c.G445A	p.A149T	exonic	ENSG00000104722.14	.	nonsynonymous SNV	ENSG00000104722.14:ENST00000221166.10:exon1:c.G445A:p.A149T	8p21.2	C3L-04475	1.981e-05	0	0	0.0003	0	0	0	0	rs531889441	11.20	D	T	D	P	D	D	L	D	N	0.557	D	D	D	0.354	0.471	0.887	0.713	T	T	T	T	T	D	3.111	23.700	0.999	D	D	0.315	3.860	0.344	3.983	1.000	0.726	0.563	0.594	0.555	.	4.760	4.760	5.070	1.176	0.616	1.000	1.000	0.995	884	Intermediate_filament,_rod_domain	.	.	ID=COSV55332080;OCCURENCE=1(large_intestine)	NEFM	550	0	627	86	0.120617110799439	TRUE	TRUE
ENSG00000091656.19	.	BCM	GRCh38.p13	chr8	76705289	76705289	+	A	A	G	Missense_Mutation	SNP	ENST00000651372.2	exon2	c.A1201G	p.M401V	exonic	ENSG00000091656.19	.	nonsynonymous SNV	ENSG00000091656.19:ENST00000651372.2:exon2:c.A1201G:p.M401V	8q21.13	C3L-04475	.	.	.	.	.	.	.	.	.	5.17	D	T	.	.	U	D	N	T	N	0.661	T	T	T	0.157	0.189	0.103	0.177	T	.	D	T	T	T	2.728	22.900	0.944	D	D	0.369	4.159	0.451	4.741	1.000	0.638	0.588	0.602	0.668	.	5.380	5.380	4.886	1.312	0.756	1.000	1.000	0.999	853	.	.	.	.	ZFHX4	184	0	236	34	0.125925925925926	TRUE	TRUE
ENSG00000107282.8	.	BCM	GRCh38.p13	chr9	69452189	69452189	+	A	A	T	Missense_Mutation	SNP	ENST00000265381.7	exon9	c.T1901A	p.L634Q	exonic	ENSG00000107282.8	.	nonsynonymous SNV	ENSG00000107282.8:ENST00000265381.7:exon9:c.T1901A:p.L634Q	9q21.12	C3L-04475	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.805	T	T	T	0.365	0.516	0.593	1.572	D	D	T	T	D	D	4.179	28.500	0.994	D	D	0.666	6.670	0.688	7.529	1.000	0.554	0.563	0.670	0.568	.	5.540	5.540	7.409	1.312	0.756	1.000	1.000	0.999	988	PTB/PI_domain	.	.	.	APBA1	174	0	199	34	0.145922746781116	TRUE	TRUE
ENSG00000136866.13	.	BCM	GRCh38.p13	chr9	113042978	113042978	+	C	C	T	Missense_Mutation	SNP	ENST00000374227.7	exon4	c.G1640A	p.C547Y	exonic	ENSG00000136866.13	.	nonsynonymous SNV	ENSG00000136866.13:ENST00000374227.7:exon4:c.G1640A:p.C547Y	9q32	C3L-04475	.	.	.	.	.	.	.	.	rs903618259	17.20	D	D	D	D	D	D	H	D	D	0.855	D	D	D	0.775	0.734	0.950	0.580	D	T	D	D	D	T	3.904	26.400	0.997	N	D	0.832	9.435	0.722	8.177	1.000	0.638	0.670	0.653	0.621	.	4.430	4.430	7.729	1.026	0.599	1.000	0.917	0.830	860	Zinc_finger_C2H2-type	.	.	.	ZFP37	135	0	140	14	0.0909090909090909	TRUE	NA
ENSG00000060339.14	.	BCM	GRCh38.p13	chr10	68753931	68753933	+	ACA	ACA	-	In_Frame_Del	DEL	ENST00000265872.11	exon11	c.1198_1200del	p.T400del	exonic	ENSG00000060339.14	.	nonframeshift deletion	ENSG00000060339.14:ENST00000265872.11:exon11:c.1198_1200del:p.T400del	10q21.3	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCAR1	226	0	258	28	0.0979020979020979	TRUE	TRUE
ENSG00000138166.6	.	BCM	GRCh38.p13	chr10	110502792	110502792	+	A	A	T	Missense_Mutation	SNP	ENST00000369583.4	exon2	c.A451T	p.I151F	exonic	ENSG00000138166.6	.	nonsynonymous SNV	ENSG00000138166.6:ENST00000369583.4:exon2:c.A451T:p.I151F	10q25.2	C3L-04475	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.119	T	T	T	0.049	0.310	0.354	0.245	T	T	T	T	T	T	1.456	15.450	0.904	D	N	-0.652	0.895	-0.548	1.126	1.000	0.731	0.750	0.644	0.592	.	6.020	0.661	1.516	0.314	0.756	0.666	0.931	0.965	912	.	.	.	.	DUSP5	230	0	245	38	0.134275618374558	TRUE	TRUE
ENSG00000187079.19	.	BCM	GRCh38.p13	chr11	12864878	12864878	+	G	G	C	Missense_Mutation	SNP	ENST00000527636.6	exon5	c.G308C	p.R103P	exonic	ENSG00000187079.19	.	nonsynonymous SNV	ENSG00000187079.19:ENST00000527636.6:exon5:c.G308C:p.R103P	11p15.3	C3L-04475	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.753	T	T	D	0.609	0.575	0.682	.	D	D	D	D	D	D	4.405	31	0.997	D	D	1.017	14.463	0.988	18.144	1.000	0.731	0.596	0.504	0.649	.	5.930	5.930	10.003	1.176	0.618	1.000	1.000	0.999	749	TEA/ATTS_domain	.	.	.	TEAD1	556	1	508	68	0.118055555555556	TRUE	TRUE
ENSG00000154096.14	.	BCM	GRCh38.p13	chr11	119419443	119419443	+	A	A	G	Missense_Mutation	SNP	ENST00000284240.10	exon4	c.T451C	p.S151P	exonic	ENSG00000154096.14	.	nonsynonymous SNV	ENSG00000154096.14:ENST00000284240.10:exon4:c.T451C:p.S151P	11q23.3	C3L-04475	.	.	.	.	.	.	.	.	.	2.20	D	T	B	B	N	N	L	T	N	0.266	T	T	D	0.250	0.359	0.725	0.544	T	T	T	T	T	T	2.283	21.500	0.967	N	N	-0.580	1.024	-0.345	1.474	1.000	0.722	0.634	0.699	0.542	.	4.850	3.860	4.152	0.094	0.756	1.000	0.988	0.987	817	.	.	.	.	THY1	402	0	550	77	0.12280701754386	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3L-04475	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	339	0	402	43	0.0966292134831461	TRUE	TRUE
ENSG00000183495.14	.	BCM	GRCh38.p13	chr12	132027442	132027442	+	G	G	A	Missense_Mutation	SNP	ENST00000389561.7	exon26	c.G5020A	p.V1674I	exonic	ENSG00000183495.14	.	nonsynonymous SNV	ENSG00000183495.14:ENST00000389561.7:exon26:c.G5020A:p.V1674I	12q24.33	C3L-04475	0.0006	9.724e-05	0.0012	0	0	0.0008	0.0056	0.0002	rs146849627	2.18	T	T	B	B	N	N	.	D	N	0.148	T	T	T	0.174	.	0.377	0.363	T	.	T	T	T	T	1.582	16.260	0.961	D	N	-0.373	1.442	-0.184	1.825	0.343	0.672	0.577	0.702	0.636	.	5.670	4.780	2.107	1.176	0.676	1.000	0.941	0.679	970	.	.	.	ID=COSV57773650;OCCURENCE=2(large_intestine)	EP400	283	0	394	24	0.0574162679425837	TRUE	TRUE
ENSG00000102452.17	.	BCM	GRCh38.p13	chr13	101283953	101283953	+	G	G	A	Missense_Mutation	SNP	ENST00000251127.11	exon10	c.C1114T	p.R372C	exonic	ENSG00000102452.17	.	nonsynonymous SNV	ENSG00000102452.17:ENST00000251127.11:exon10:c.C1114T:p.R372C	13q33.1	C3L-04475	8.317e-06	0	8.754e-05	0	0	0	0	0	rs549926959	13.20	T	T	D	P	D	D	N	D	N	0.845	D	D	D	0.736	0.555	0.646	2.121	T	T	D	D	D	D	3.736	25.600	0.999	D	D	0.416	4.441	0.481	4.988	1.000	0.615	0.574	0.574	0.655	.	5.450	4.520	4.633	1.157	0.595	1.000	1.000	0.999	826	.	.	.	ID=COSV51930613;OCCURENCE=2(large_intestine),1(stomach),2(haematopoietic_and_lymphoid_tissue)	NALCN	221	0	338	28	0.0765027322404372	TRUE	TRUE
ENSG00000036530.9	.	BCM	GRCh38.p13	chr14	99706765	99706765	+	G	G	A	Missense_Mutation	SNP	ENST00000261835.8	exon6	c.G562A	p.A188T	exonic	ENSG00000036530.9	.	nonsynonymous SNV	ENSG00000036530.9:ENST00000261835.8:exon6:c.G562A:p.A188T	14q32.2	C3L-04475	1.652e-05	9.643e-05	0	0	0	1.503e-05	0	0	rs148568536	0.20	T	T	B	B	N	N	N	T	N	0.283	T	T	T	0.229	.	0.159	0.836	T	T	T	T	T	T	0.802	9.415	0.393	N	N	-0.577	1.029	-0.499	1.203	0.012	0.578	0.574	0.608	0.542	.	4.170	-0.025	0.030	-0.084	-0.116	0.915	0.993	0.990	941	.	.	.	.	CYP46A1	115	0	180	21	0.104477611940299	TRUE	NA
ENSG00000058335.15	.	BCM	GRCh38.p13	chr15	79004051	79004051	+	A	A	G	Missense_Mutation	SNP	ENST00000419573.7	exon16	c.T2248C	p.S750P	exonic	ENSG00000058335.15	.	nonsynonymous SNV	ENSG00000058335.15:ENST00000419573.7:exon16:c.T2248C:p.S750P	15q25.1	C3L-04475	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	L	T	N	0.833	T	T	D	0.321	0.362	0.416	1.344	T	T	D	T	D	T	2.272	21.400	0.993	D	D	0.342	4.004	0.201	3.190	1.000	0.493	0.587	0.602	0.613	.	4.350	4.350	9.129	1.278	0.691	1.000	0.070	0.027	789	Ras-like_guanine_nucleotide_exchange_factor,_N-terminal	.	.	.	RASGRF1	236	1	306	29	0.0865671641791045	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674196	7674196	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.C767T	p.T256I	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.C767T:p.T256I	17p13.1	C3L-04475	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.969	D	D	D	0.932	0.949	0.995	0.400	T	D	D	D	D	D	3.828	26.000	0.998	D	D	0.669	6.710	0.550	5.647	0.799	0.722	0.702	0.725	0.735	.	4.620	3.650	10.003	1.174	0.676	1.000	0.986	0.683	432	p53,_DNA-binding_domain	.	.	ID=COSV52987484;OCCURENCE=1(oesophagus),2(large_intestine),1(stomach),1(prostate),1(upper_aerodigestive_tract)	TP53	329	1	345	62	0.152334152334152	TRUE	TRUE
ENSG00000105397.14	.	BCM	GRCh38.p13	chr19	10354558	10354558	+	G	G	A	Missense_Mutation	SNP	ENST00000525621.6	exon19	c.C2669T	p.T890M	exonic	ENSG00000105397.14	.	nonsynonymous SNV	ENSG00000105397.14:ENST00000525621.6:exon19:c.C2669T:p.T890M	19p13.2	C3L-04475	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	D	D	0.552	D	D	D	0.509	0.394	0.815	0.927	T	T	D	D	D	D	3.588	25.000	0.998	D	N	0.035	2.637	-0.021	2.289	0.961	0.726	0.725	0.594	0.714	.	5.450	3.230	2.966	1.176	0.676	0.998	0.635	0.625	774	.	.	.	ID=COSV53384829;OCCURENCE=1(large_intestine),1(skin),1(lung)	TYK2	347	0	477	49	0.0931558935361217	TRUE	TRUE
ENSG00000105143.12	.	BCM	GRCh38.p13	chr19	14952977	14952977	+	C	C	T	Missense_Mutation	SNP	ENST00000221742.7	exon8	c.G1450A	p.G484S	exonic	ENSG00000105143.12	.	nonsynonymous SNV	ENSG00000105143.12:ENST00000221742.7:exon8:c.G1450A:p.G484S	19p13.12	C3L-04475	8.24e-06	0	0	0	0	1.499e-05	0	0	rs770765624	18.20	D	D	D	D	D	D	M	T	D	0.647	D	T	D	0.628	0.805	0.762	2.370	D	D	D	D	D	D	4.074	27.500	0.999	D	D	0.757	7.994	0.679	7.379	1.000	0.615	0.574	0.659	0.564	.	4.410	4.410	6.027	0.962	0.510	1.000	0.878	0.960	976	.	.	.	ID=COSV55669575;OCCURENCE=1(large_intestine)	SLC1A6	165	0	241	21	0.0801526717557252	TRUE	TRUE
ENSG00000173480.11	.	BCM	GRCh38.p13	chr19	57909495	57909495	+	A	A	T	Missense_Mutation	SNP	ENST00000312026.6	exon3	c.T783A	p.D261E	exonic	ENSG00000173480.11	.	nonsynonymous SNV	ENSG00000173480.11:ENST00000312026.6:exon3:c.T783A:p.D261E	19q13.43	C3L-04475	.	.	.	.	.	.	.	.	.	2.19	D	D	P	B	.	N	N	T	N	0.070	T	T	T	0.046	0.299	0.549	.	T	T	T	T	T	T	0.628	7.782	0.886	N	N	-1.000	0.404	-1.167	0.312	0.001	0.707	0.725	0.702	0.714	.	1.910	-1.700	-0.777	0.773	0.270	0.000	0.013	0.004	982	Zinc_finger_C2H2-type	.	.	.	ZNF417	265	1	264	32	0.108108108108108	NA	TRUE
ENSG00000101292.7	.	BCM	GRCh38.p13	chr20	5302231	5302231	+	C	C	T	Missense_Mutation	SNP	ENST00000217270.3	exon2	c.G964A	p.A322T	exonic	ENSG00000101292.7	.	nonsynonymous SNV	ENSG00000101292.7:ENST00000217270.3:exon2:c.G964A:p.A322T	20p12.3	C3L-04475	4.942e-05	0	0	0	0	0	0.0011	0.0003	rs779869864	13.20	D	D	D	D	D	D	M	T	D	0.949	T	T	D	0.473	0.725	0.855	.	T	T	T	D	D	T	4.077	27.600	0.999	D	D	0.853	9.899	0.801	10.141	1.000	0.638	0.574	0.653	0.542	.	5.050	5.050	7.426	0.126	0.596	1.000	0.990	0.994	952	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV54086366;OCCURENCE=4(large_intestine),1(skin),1(endometrium)	PROKR2	586	0	728	93	0.113276492082826	TRUE	TRUE
ENSG00000197586.13	.	BCM	GRCh38.p13	chr20	25224139	25224139	+	G	G	A	Missense_Mutation	SNP	ENST00000376652.9	exon13	c.G1225A	p.E409K	exonic	ENSG00000197586.13	.	nonsynonymous SNV	ENSG00000197586.13:ENST00000376652.9:exon13:c.G1225A:p.E409K	20p11.21	C3L-04475	.	.	.	.	.	.	.	.	rs780480288	6.20	T	T	D	B	N	D	L	T	N	0.677	T	T	T	0.100	0.642	0.205	0.703	T	T	T	T	D	D	2.767	23.000	0.984	D	D	0.218	3.385	0.289	3.652	1.000	0.722	0.702	0.644	0.735	.	5.220	5.220	4.728	1.176	0.676	1.000	0.858	0.941	649	.	.	.	.	ENTPD6	47	0	117	10	0.078740157480315	TRUE	NA
ENSG00000198185.11	.	BCM	GRCh38.p13	chr20	46504666	46504666	+	C	C	G	Missense_Mutation	SNP	ENST00000347606.8	exon3	c.G96C	p.R32S	exonic	ENSG00000198185.11	.	nonsynonymous SNV	ENSG00000198185.11:ENST00000347606.8:exon3:c.G96C:p.R32S	20q13.12	C3L-04475	.	.	.	.	.	.	.	.	.	5.19	D	D	P	B	.	N	H	T	D	0.469	T	T	T	0.099	0.666	0.233	0.074	T	T	T	T	D	T	0.945	10.940	0.957	N	N	-0.506	1.164	-0.711	0.884	0.000	0.707	0.670	0.725	0.564	.	3.020	-0.101	-1.043	-0.944	-0.242	0.000	0.888	0.991	948	Krueppel-associated_box	.	.	.	ZNF334	140	0	188	10	0.0505050505050505	TRUE	NA
ENSG00000130589.16	.	BCM	GRCh38.p13	chr20	63560317	63560317	+	G	G	A	Missense_Mutation	SNP	ENST00000467148.1	exon17	c.C7511T	p.T2504I	exonic	ENSG00000130589.16	.	nonsynonymous SNV	ENSG00000130589.16:ENST00000467148.1:exon17:c.C7511T:p.T2504I	20q13.33	C3L-04475	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	T	N	0.285	T	T	D	0.155	0.408	0.388	0.213	T	T	T	T	T	T	2.598	22.600	0.874	D	N	-0.719	0.782	-0.547	1.128	0.969	0.707	0.644	0.723	0.714	.	3.800	2.820	4.416	-0.168	-0.185	1.000	0.099	0.086	.	.	.	.	.	HELZ2	69	0	105	9	0.0789473684210526	TRUE	TRUE
ENSG00000175329.13	.	BCM	GRCh38.p13	chr22	35067193	35067193	+	A	A	T	Missense_Mutation	SNP	ENST00000404699.7	exon2	c.A106T	p.I36F	exonic	ENSG00000175329.13	.	nonsynonymous SNV	ENSG00000175329.13:ENST00000404699.7:exon2:c.A106T:p.I36F	22q12.3	C3L-04475	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	D	N	0.459	D	D	D	0.505	0.283	0.902	0.064	T	T	D	D	D	T	3.749	25.600	0.989	D	D	0.517	5.167	0.509	5.241	1.000	0.487	0.547	0.574	0.564	.	5.130	5.130	4.457	1.298	0.740	1.000	0.827	0.945	962	.	.	.	ID=COSV58088022;OCCURENCE=1(liver)	ISX	573	1	724	99	0.120291616038882	NA	TRUE
ENSG00000187823.3	.	BCM	GRCh38.p13	chrX	112455624	112455624	+	G	G	A	Missense_Mutation	SNP	ENST00000340433.3	exon1	c.G896A	p.R299Q	exonic	ENSG00000187823.3	.	nonsynonymous SNV	ENSG00000187823.3:ENST00000340433.3:exon1:c.G896A:p.R299Q	Xq23	C3L-04475	4.781e-05	0	0	0.0002	0	6.486e-05	0	0	rs751946941	4.18	T	T	D	D	N	N	.	T	N	0.222	T	T	D	0.279	0.396	0.205	0.068	T	T	T	T	T	T	2.218	21.000	0.983	D	.	.	.	.	.	0.000	.	.	.	.	.	3.800	2.940	1.487	0.161	-0.105	1.000	0.324	0.259	821	.	.	.	.	RTL4	76	0	82	21	0.203883495145631	TRUE	NA
ENSG00000133065.11	.	BCM	GRCh38.p13	chr1	205798970	205798970	+	G	G	C	Silent	SNP	ENST00000367137.4	exon5	c.C684G	p.A228A	exonic	ENSG00000133065.11	.	synonymous SNV	ENSG00000133065.11:ENST00000367137.4:exon5:c.C684G:p.A228A	1q32.1	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC41A1	436	1	584	75	0.113808801213961	TRUE	TRUE
ENSG00000143507.18	.	BCM	GRCh38.p13	chr1	221739568	221739568	+	C	C	T	Silent	SNP	ENST00000366899.4	exon2	c.G177A	p.T59T	exonic	ENSG00000143507.18	.	synonymous SNV	ENSG00000143507.18:ENST00000366899.4:exon2:c.G177A:p.T59T	1q41	C3L-04475	1.647e-05	0	0	0	0	0	0	0.0001	rs754587624	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60458562;OCCURENCE=1(large_intestine)	DUSP10	221	0	280	38	0.119496855345912	TRUE	TRUE
ENSG00000174255.7	.	BCM	GRCh38.p13	chr3	114236805	114236805	+	G	G	A	Silent	SNP	ENST00000482457.4	exon1	c.C270T	p.V90V	exonic	ENSG00000174255.7	.	synonymous SNV	ENSG00000174255.7:ENST00000482457.4:exon1:c.C270T:p.V90V	3q13.31	C3L-04475	2.49e-05	0.0002	0	0	0	1.509e-05	0	0	rs111785883	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF80	234	0	335	47	0.12303664921466	TRUE	NA
ENSG00000144893.12	.	BCM	GRCh38.p13	chr3	151378018	151378018	+	C	C	T	Silent	SNP	ENST00000474524.5	exon29	c.C4218T	p.S1406S	exonic	ENSG00000144893.12	.	synonymous SNV	ENSG00000144893.12:ENST00000474524.5:exon29:c.C4218T:p.S1406S	3q25.1	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56387292;OCCURENCE=1(skin),1(upper_aerodigestive_tract)	MED12L	85	0	137	14	0.0927152317880795	TRUE	TRUE
ENSG00000132464.13	.	BCM	GRCh38.p13	chr4	70643973	70643973	+	T	T	A	Silent	SNP	ENST00000396073.4	exon9	c.T2547A	p.P849P	exonic	ENSG00000132464.13	.	synonymous SNV	ENSG00000132464.13:ENST00000396073.4:exon9:c.T2547A:p.P849P	4q13.3	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ENAM	537	0	603	77	0.113235294117647	TRUE	TRUE
ENSG00000155511.18	.	BCM	GRCh38.p13	chr5	153647040	153647040	+	G	G	A	Silent	SNP	ENST00000285900.10	exon3	c.G333A	p.P111P	exonic	ENSG00000155511.18	.	synonymous SNV	ENSG00000155511.18:ENST00000285900.10:exon3:c.G333A:p.P111P	5q33.2	C3L-04475	8.241e-06	0	0	0	0	0	0	6.056e-05	rs750448884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53597890;OCCURENCE=1(stomach),1(skin),1(endometrium)	GRIA1	516	0	691	81	0.104922279792746	TRUE	TRUE
ENSG00000211968.3	.	BCM	GRCh38.p13	chr14	106622497	106622497	+	G	G	A	Silent	SNP	ENST00000390628.3	exon2	c.C213T	p.V71V	exonic	ENSG00000211968.3	.	synonymous SNV	ENSG00000211968.3:ENST00000390628.3:exon2:c.C213T:p.V71V	14q32.33	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHV1-58	675	1	843	91	0.0974304068522484	TRUE	TRUE
ENSG00000185823.5	.	BCM	GRCh38.p13	chr15	24676389	24676389	+	C	C	T	Silent	SNP	ENST00000329468.5	exon1	c.C522T	p.D174D	exonic	ENSG00000185823.5	.	synonymous SNV	ENSG00000185823.5:ENST00000329468.5:exon1:c.C522T:p.D174D	15q11.2	C3L-04475	3.637e-05	9.956e-05	0	0	0	4.744e-05	0	0	rs368120585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61504571;OCCURENCE=1(large_intestine),1(central_nervous_system),1(ovary),1(stomach),1(prostate)	NPAP1	50	0	55	7	0.112903225806452	TRUE	TRUE
ENSG00000182768.9	.	BCM	GRCh38.p13	chr15	90265754	90265754	+	C	C	T	Silent	SNP	ENST00000379095.5	exon1	c.C42T	p.C14C	exonic	ENSG00000182768.9	.	synonymous SNV	ENSG00000182768.9:ENST00000379095.5:exon1:c.C42T:p.C14C	15q26.1	C3L-04475	2.614e-05	0	0	0	0	4.772e-05	0	0	rs748216905	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NGRN	375	1	504	57	0.101604278074866	TRUE	NA
ENSG00000275832.5	.	BCM	GRCh38.p13	chr17	38467000	38467000	+	G	G	T	Silent	SNP	ENST00000622683.5	exon7	c.G1317T	p.R439R	exonic	ENSG00000275832.5	.	synonymous SNV	ENSG00000275832.5:ENST00000622683.5:exon7:c.G1317T:p.R439R	17q12	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARHGAP23	498	2	621	61	0.0894428152492669	TRUE	TRUE
ENSG00000125851.10	.	BCM	GRCh38.p13	chr20	17453867	17453867	+	C	C	T	Silent	SNP	ENST00000262545.7	exon9	c.C1011T	p.D337D	exonic	ENSG00000125851.10	.	synonymous SNV	ENSG00000125851.10:ENST00000262545.7:exon9:c.C1011T:p.D337D	20p12.1	C3L-04475	.	.	.	.	.	.	.	.	rs1020319388	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCSK2	452	0	666	70	0.0951086956521739	TRUE	NA
ENSG00000175329.13	.	BCM	GRCh38.p13	chr22	35067192	35067192	+	G	G	A	Silent	SNP	ENST00000404699.7	exon2	c.G105A	p.A35A	exonic	ENSG00000175329.13	.	synonymous SNV	ENSG00000175329.13:ENST00000404699.7:exon2:c.G105A:p.A35A	22q12.3	C3L-04475	2.841e-05	0.0001	0	0.0003	0	0	0	0	rs760200279	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100434153;OCCURENCE=1(pancreas)	ISX	505	0	617	85	0.121082621082621	TRUE	NA
ENSG00000175718.10	.	BCM	GRCh38.p13	chrX	115191715	115191715	+	C	C	T	Silent	SNP	ENST00000424776.5	exon1	c.C2274T	p.D758D	exonic	ENSG00000175718.10	.	synonymous SNV	ENSG00000175718.10:ENST00000424776.5:exon1:c.C2274T:p.D758D	Xq23	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57750383;OCCURENCE=1(large_intestine),1(biliary_tract)	RBMXL3	164	1	188	60	0.241935483870968	TRUE	TRUE
ENSG00000253441.1	.	BCM	GRCh38.p13	chr14	106289100	106289100	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000253441.1	.	.	.	14q32.33	C3L-04475	.	.	.	.	.	.	.	.	rs925719527	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHV3-25	40	0	46	8	0.148148148148148	TRUE	NA
ENSG00000140368.13	.	BCM	GRCh38.p13	chr15	76995496	76995496	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000140368.13	ENST00000558012.6:c.-78C>T	.	.	15q24.3	C3L-04475	2.362e-05	0.0002	0	0.0002	0	0	0	0	rs371644004	2.10	D	D	.	.	.	N	.	T	N	.	.	.	.	.	.	0.599	.	.	.	T	T	.	T	1.117	12.940	0.997	N	N	.	.	.	.	1.000	0.403	0.299	0.578	0.563	.	4.120	3.160	0.004	1.000	0.599	0.019	0.356	0.711	294	.	.	.	.	PSTPIP1	84	0	161	22	0.120218579234973	TRUE	NA
ENSG00000252608.1	.	BCM	GRCh38.p13	chr16	81130579	81130579	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000252608.1;ENSG00000286759.1	dist=23940;dist=21241	.	.	16q23.2	C3L-04475	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNU6-1191P	233	0	351	26	0.0689655172413793	TRUE	NA
ENSG00000167037.18	.	BCM	GRCh38.p13	chr22	24855848	24855848	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000167037.18	.	.	.	22q11.23	C3L-04475	0.0034	0.0411	0.0060	0	0	0	0	0.0002	rs114432790	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV68509518;OCCURENCE=1(pancreas)	SGSM1	104	0	134	12	0.0821917808219178	TRUE	NA
ENSG00000125944.20	.	BCM	GRCh38.p13	chr1	23310932	23310932	+	T	T	C	Missense_Mutation	SNP	ENST00000302271.11	exon11	c.A1424G	p.Y475C	exonic	ENSG00000125944.20	.	nonsynonymous SNV	ENSG00000125944.20:ENST00000302271.11:exon11:c.A1424G:p.Y475C	1p36.12	C3L-04853	8.242e-06	0	8.643e-05	0	0	0	0	0	rs763561835	16.19	D	D	D	D	D	D	M	T	D	0.783	T	T	D	0.419	.	0.607	0.746	D	D	D	D	D	.	4.252	29.100	0.985	D	D	0.847	9.778	0.818	10.680	1.000	0.719	0.725	0.723	0.711	.	5.720	5.720	7.970	1.138	0.665	1.000	1.000	0.999	322	.	.	.	.	HNRNPR	457	0	240	45	0.157894736842105	TRUE	NA
ENSG00000116260.17	.	BCM	GRCh38.p13	chr1	180196474	180196474	+	G	G	T	Missense_Mutation	SNP	ENST00000367602.8	exon12	c.G1681T	p.A561S	exonic	ENSG00000116260.17	.	nonsynonymous SNV	ENSG00000116260.17:ENST00000367602.8:exon12:c.G1681T:p.A561S	1q25.2	C3L-04853	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.091	T	T	T	0.013	0.275	0.040	0.108	T	T	T	T	T	T	-0.574	0.083	0.230	N	N	-1.916	0.014	-2.017	0.012	1.000	0.707	0.725	0.725	0.714	.	4.540	-9.080	-2.427	-0.575	-0.159	0.000	0.000	0.001	790	.	.	.	.	QSOX1	190	1	122	7	0.0542635658914729	TRUE	TRUE
ENSG00000182263.14	.	BCM	GRCh38.p13	chr2	163611579	163611579	+	G	G	A	Nonsense_Mutation	SNP	ENST00000333129.4	exon3	c.C253T	p.R85X	exonic	ENSG00000182263.14	.	stopgain	ENSG00000182263.14:ENST00000333129.4:exon3:c.C253T:p.R85X	2q24.3	C3L-04853	8.281e-06	0	8.639e-05	0	0	0	0	0	rs568198210	4.6	.	.	.	.	U	D	.	.	.	0.404	.	.	.	.	.	.	.	.	.	D	D	.	.	6.796	36	0.998	D	N	0.866	10.208	0.758	8.985	0.999	0.744	0.616	0.630	0.700	.	6.170	5.250	3.033	1.176	0.676	1.000	0.966	0.812	860	.	.	.	ID=COSV60764452;OCCURENCE=2(upper_aerodigestive_tract),1(endometrium)	FIGN	317	3	222	27	0.108433734939759	TRUE	TRUE
ENSG00000114650.20	.	BCM	GRCh38.p13	chr3	47418758	47418758	+	G	G	A	Missense_Mutation	SNP	ENST00000265565.10	exon14	c.C2026T	p.R676C	exonic	ENSG00000114650.20	.	nonsynonymous SNV	ENSG00000114650.20:ENST00000265565.10:exon14:c.C2026T:p.R676C	3p21.31	C3L-04853	3.418e-05	0	0	0	0	5.922e-05	0	0	rs767799241	9.20	D	D	D	B	N	D	N	T	D	0.462	T	T	D	0.189	0.225	0.765	0.430	T	T	T	T	D	D	2.860	23.100	0.998	D	N	-0.204	1.866	-0.272	1.622	1.000	0.672	0.702	0.780	0.636	.	4.650	3.760	2.650	1.089	0.590	0.109	0.946	0.099	20	.	.	.	.	SCAP	149	0	78	8	0.0930232558139535	TRUE	NA
ENSG00000178804.7	.	BCM	GRCh38.p13	chr3	129550759	129550759	+	T	T	A	Missense_Mutation	SNP	ENST00000324382.6	exon4	c.T757A	p.Y253N	exonic	ENSG00000178804.7	.	nonsynonymous SNV	ENSG00000178804.7:ENST00000324382.6:exon4:c.T757A:p.Y253N	3q22.1	C3L-04853	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.105	T	T	T	0.039	0.259	0.055	0.089	T	T	T	T	T	T	-0.222	0.459	0.649	N	N	-1.530	0.072	-1.540	0.094	1.000	0.497	0.590	0.547	0.646	.	3.530	-0.494	-0.551	-0.852	-1.843	0.000	0.001	0.001	514	.	.	.	.	H1-8	259	0	147	15	0.0925925925925926	TRUE	TRUE
ENSG00000145113.22	.	BCM	GRCh38.p13	chr3	195765303	195765303	+	G	G	A	Nonsense_Mutation	SNP	ENST00000463781.8	exon9	c.C13765T	p.R4589X	exonic	ENSG00000145113.22	.	stopgain	ENSG00000145113.22:ENST00000463781.8:exon9:c.C13765T:p.R4589X	3q29	C3L-04853	3.403e-05	0.0001	8.743e-05	0	0	1.548e-05	0	6.266e-05	rs771701130	3.6	.	.	.	.	N	A	.	.	.	0.874	.	.	.	.	.	.	.	.	.	D	D	.	.	8.019	40	0.981	N	N	-0.098	2.182	-0.418	1.339	0.000	0.554	0.588	0.604	0.613	.	4.250	-0.041	-1.034	0.230	-0.190	0.000	0.714	0.971	830	AMOP_domain	.	.	ID=COSV57801324;OCCURENCE=1(stomach),1(endometrium)	MUC4	252	0	153	11	0.0670731707317073	TRUE	TRUE
ENSG00000078295.17	.	BCM	GRCh38.p13	chr5	7709296	7709296	+	G	G	A	Missense_Mutation	SNP	ENST00000338316.9	exon10	c.G1487A	p.R496Q	exonic	ENSG00000078295.17	.	nonsynonymous SNV	ENSG00000078295.17:ENST00000338316.9:exon10:c.G1487A:p.R496Q	5p15.31	C3L-04853	1.656e-05	0	0	0	0	1.504e-05	0	6.104e-05	rs576240306	11.20	T	T	B	B	D	D	M	T	N	0.501	T	T	T	0.506	0.516	0.882	0.973	D	D	D	D	D	D	2.900	23.200	0.999	D	D	0.259	3.573	0.407	4.407	1.000	0.672	0.574	0.702	0.564	.	5.620	5.620	6.493	1.176	0.674	1.000	1.000	0.998	917	Adenylate_cyclase,_conserved_domain	.	.	ID=COSV57864504;OCCURENCE=1(cervix),2(large_intestine),1(pancreas)	ADCY2	326	0	182	19	0.0945273631840796	TRUE	TRUE
ENSG00000112902.12	.	BCM	GRCh38.p13	chr5	9054173	9054173	+	C	C	T	Missense_Mutation	SNP	ENST00000382496.10	exon19	c.G2603A	p.C868Y	exonic	ENSG00000112902.12	.	nonsynonymous SNV	ENSG00000112902.12:ENST00000382496.10:exon19:c.G2603A:p.C868Y	5p15.31	C3L-04853	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.989	D	D	D	0.728	0.779	0.933	1.418	T	T	D	D	D	D	3.915	26.400	0.997	D	D	1.023	14.658	0.885	13.126	1.000	0.706	0.588	0.710	0.613	.	5.590	5.590	7.521	1.026	0.599	1.000	0.013	0.762	833	.	.	.	ID=COSV66807066;OCCURENCE=1(liver)	SEMA5A	331	0	227	15	0.0619834710743802	TRUE	TRUE
ENSG00000145734.19	.	BCM	GRCh38.p13	chr5	71562397	71562397	+	G	G	T	Missense_Mutation	SNP	ENST00000358731.9	exon38	c.G7620T	p.K2540N	exonic	ENSG00000145734.19	.	nonsynonymous SNV	ENSG00000145734.19:ENST00000358731.9:exon38:c.G7620T:p.K2540N	5q13.2	C3L-04853	.	.	.	.	.	.	.	.	.	1.20	D	T	B	B	N	N	N	T	N	0.112	T	T	T	0.059	0.273	0.130	0.045	T	T	T	T	T	T	1.718	17.150	0.992	N	N	-0.741	0.745	-0.668	0.946	0.002	0.732	0.709	0.651	0.728	.	5.870	0.596	0.454	-0.101	0.676	0.297	0.197	0.609	422	.	.	.	.	BDP1	212	0	88	5	0.0537634408602151	TRUE	TRUE
ENSG00000183775.11	.	BCM	GRCh38.p13	chr5	144474029	144474029	+	A	A	G	Missense_Mutation	SNP	ENST00000512467.6	exon4	c.A1202G	p.D401G	exonic	ENSG00000183775.11	.	nonsynonymous SNV	ENSG00000183775.11:ENST00000512467.6:exon4:c.A1202G:p.D401G	5q31.3	C3L-04853	.	.	.	.	.	.	.	.	.	12.20	D	D	B	B	D	D	L	T	N	0.939	T	T	D	0.386	0.398	0.861	1.000	D	T	D	D	D	D	3.357	24.300	0.998	D	D	0.089	2.844	0.277	3.584	0.388	0.554	0.574	0.618	0.568	.	6.170	5.020	8.841	1.312	0.756	1.000	1.000	1.000	893	.	.	.	.	KCTD16	358	1	191	27	0.123853211009174	TRUE	TRUE
ENSG00000124496.12	.	BCM	GRCh38.p13	chr6	42246541	42246541	+	G	G	T	Nonsense_Mutation	SNP	ENST00000372922.8	exon14	c.C2660A	p.S887X	exonic	ENSG00000124496.12	.	stopgain	ENSG00000124496.12:ENST00000372922.8:exon14:c.C2660A:p.S887X	6p21.1	C3L-04853	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.547	.	.	.	.	.	.	.	.	.	D	D	.	.	8.718	45	0.997	D	N	0.925	11.707	0.801	10.168	1.000	0.732	0.710	0.744	0.655	.	5.170	5.170	6.284	1.176	0.676	1.000	1.000	0.998	889	SANT/Myb_domain;SANT_domain	.	.	.	TRERF1	129	0	48	4	0.0769230769230769	TRUE	TRUE
ENSG00000224940.8	.	BCM	GRCh38.p13	chr7	128352058	128352058	+	C	C	T	Missense_Mutation	SNP	ENST00000446477.6	exon6	c.G1498A	p.G500R	exonic	ENSG00000224940.8	.	nonsynonymous SNV	ENSG00000224940.8:ENST00000446477.6:exon6:c.G1498A:p.G500R	7q32.1	C3L-04853	.	.	.	.	.	.	.	.	.	10.17	T	D	D	D	.	D	M	.	N	0.635	T	T	D	0.147	0.354	0.214	.	D	T	D	T	D	T	3.205	23.900	0.998	D	.	0.414	4.433	0.355	4.057	1.000	0.598	0.563	0.608	0.639	.	3.250	3.250	2.633	0.918	0.470	0.529	0.623	0.859	638	.	.	.	.	PRRT4	86	0	75	8	0.0963855421686747	TRUE	TRUE
ENSG00000257335.8	.	BCM	GRCh38.p13	chr7	142027133	142027133	+	C	C	T	Missense_Mutation	SNP	ENST00000549489.6	exon9	c.C1001T	p.A334V	exonic	ENSG00000257335.8	.	nonsynonymous SNV	ENSG00000257335.8:ENST00000549489.6:exon9:c.C1001T:p.A334V	7q34	C3L-04853	2.499e-05	0	8.696e-05	0	0	3.016e-05	0	0	rs782549716	10.20	D	D	P	B	N	N	M	D	N	0.513	T	D	D	0.380	0.435	0.863	0.044	T	T	T	T	D	D	2.525	22.500	0.998	D	D	0.285	3.704	0.235	3.361	1.000	0.487	0.574	0.547	0.564	.	5.550	5.550	7.520	1.026	0.599	0.821	0.022	0.144	923	.	.	.	ID=COSV72073695;OCCURENCE=1(oesophagus),2(endometrium)	MGAM	294	0	192	20	0.0943396226415094	TRUE	TRUE
ENSG00000120899.18	.	BCM	GRCh38.p13	chr8	27419943	27419943	+	C	C	T	Missense_Mutation	SNP	ENST00000346049.10	exon3	c.C253T	p.R85W	exonic	ENSG00000120899.18	.	nonsynonymous SNV	ENSG00000120899.18:ENST00000346049.10:exon3:c.C253T:p.R85W	8p21.2	C3L-04853	4.952e-05	0.0002	0	0	0	1.501e-05	0	0.0002	rs369608545	6.20	D	D	B	B	N	N	N	T	D	0.258	T	T	D	0.320	.	0.772	0.427	T	T	T	T	T	T	3.373	24.300	0.998	D	D	-0.058	2.311	0.110	2.777	1.000	0.672	0.702	0.653	0.568	.	5.150	5.150	0.308	1.026	0.599	0.991	1.000	0.990	878	0.000	.	.	ID=COSV57766597;OCCURENCE=1(skin)	PTK2B	295	0	239	16	0.0627450980392157	TRUE	TRUE
ENSG00000107331.17	.	BCM	GRCh38.p13	chr9	137010727	137010727	+	C	C	A	Missense_Mutation	SNP	ENST00000371605.7	exon39	c.G6064T	p.V2022L	exonic	ENSG00000107331.17	.	nonsynonymous SNV	ENSG00000107331.17:ENST00000371605.7:exon39:c.G6064T:p.V2022L	9q34.3	C3L-04853	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	N	D	L	D	N	0.452	T	T	D	0.242	0.322	0.455	0.699	D	T	T	T	T	T	2.275	21.400	0.896	D	D	-0.549	1.082	-0.425	1.329	0.996	0.696	0.634	0.723	0.700	.	3.620	3.620	5.114	-0.019	0.435	1.000	0.024	0.697	982	.	.	.	ID=COSV55806269;OCCURENCE=1(lung)	ABCA2	218	0	126	21	0.142857142857143	TRUE	TRUE
ENSG00000169126.16	.	BCM	GRCh38.p13	chr10	27862603	27862603	+	C	C	A	Missense_Mutation	SNP	ENST00000305242.10	exon18	c.G2630T	p.R877L	exonic	ENSG00000169126.16	.	nonsynonymous SNV	ENSG00000169126.16:ENST00000305242.10:exon18:c.G2630T:p.R877L	10p12.1	C3L-04853	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.598	D	D	D	0.761	0.491	0.924	0.258	T	T	D	D	D	D	4.163	28.300	0.998	D	D	0.823	9.255	0.808	10.366	0.985	0.638	0.574	0.653	0.668	.	5.750	5.750	5.929	1.020	0.599	1.000	1.000	0.999	763	.	.	.	ID=COSV59467198;OCCURENCE=2(thyroid)	ARMC4	157	0	49	8	0.140350877192982	TRUE	TRUE
ENSG00000138347.15	.	BCM	GRCh38.p13	chr10	68175332	68175332	+	G	G	T	Missense_Mutation	SNP	ENST00000358913.9	exon12	c.G2574T	p.Q858H	exonic	ENSG00000138347.15	.	nonsynonymous SNV	ENSG00000138347.15:ENST00000358913.9:exon12:c.G2574T:p.Q858H	10q21.3	C3L-04853	.	.	.	.	.	.	.	.	.	5.20	T	T	D	P	D	N	M	T	N	0.341	T	T	T	0.156	0.231	0.700	0.128	T	T	T	T	D	T	2.616	22.700	0.995	D	N	0.371	4.168	0.406	4.402	0.986	0.554	0.574	0.547	0.621	.	5.870	4.970	1.701	1.172	0.672	1.000	1.000	0.997	930	.	.	.	ID=COSV62732852;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	MYPN	372	0	158	15	0.0867052023121387	TRUE	TRUE
ENSG00000154478.4	.	BCM	GRCh38.p13	chr10	123666785	123666785	+	G	G	A	Missense_Mutation	SNP	ENST00000284674.2	exon1	c.G378A	p.M126I	exonic	ENSG00000154478.4	.	nonsynonymous SNV	ENSG00000154478.4:ENST00000284674.2:exon1:c.G378A:p.M126I	10q26.13	C3L-04853	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	N	T	N	0.134	T	T	T	0.095	0.606	0.300	1.036	T	T	T	T	T	T	2.050	19.630	0.975	D	N	-0.326	1.552	-0.163	1.878	0.911	0.516	0.610	0.504	0.563	.	4.110	3.110	0.684	1.172	0.672	1.000	1.000	0.999	779	GPCR,_rhodopsin-like,_7TM	.	.	.	GPR26	545	0	317	34	0.0968660968660969	TRUE	TRUE
ENSG00000070985.13	.	BCM	GRCh38.p13	chr11	2413134	2413134	+	C	C	T	Missense_Mutation	SNP	ENST00000155858.10	exon14	c.G2096A	p.R699Q	exonic	ENSG00000070985.13	.	nonsynonymous SNV	ENSG00000070985.13:ENST00000155858.10:exon14:c.G2096A:p.R699Q	11p15.5	C3L-04853	0.0002	0	0	0	0	0	0	0.0006	rs770117161	2.20	T	T	B	B	N	N	L	D	N	0.070	T	T	D	0.197	0.390	0.040	0.104	T	T	T	T	T	T	2.785	23.000	0.834	N	N	-1.392	0.120	-1.433	0.135	0.134	0.403	0.547	0.578	0.563	.	3.690	-3.150	0.360	-0.759	-0.252	0.172	0.090	0.014	988	.	.	.	.	TRPM5	196	0	119	27	0.184931506849315	TRUE	NA
ENSG00000149256.16	.	BCM	GRCh38.p13	chr11	78658646	78658646	+	C	C	G	Missense_Mutation	SNP	ENST00000278550.12	exon34	c.G7722C	p.L2574F	exonic	ENSG00000149256.16	.	nonsynonymous SNV	ENSG00000149256.16:ENST00000278550.12:exon34:c.G7722C:p.L2574F	11q14.1	C3L-04853	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	D	D	N	D	N	0.135	T	T	D	0.193	0.340	0.239	0.314	T	T	T	T	D	D	2.297	21.600	0.987	D	N	-0.215	1.833	-0.043	2.219	0.977	0.615	0.563	0.659	0.564	.	5.650	3.800	1.385	0.127	0.596	1.000	0.999	0.998	880	.	.	.	.	TENM4	458	0	349	26	0.0693333333333333	TRUE	TRUE
ENSG00000196119.8	.	BCM	GRCh38.p13	chr11	124570573	124570573	+	G	G	A	Missense_Mutation	SNP	ENST00000642111.1	exon1	c.G505A	p.G169R	exonic	ENSG00000196119.8	.	nonsynonymous SNV	ENSG00000196119.8:ENST00000642111.1:exon1:c.G505A:p.G169R	11q24.2	C3L-04853	2.473e-05	0	0.0003	0	0	0	0	0	rs753980426	8.16	.	.	D	D	N	D	H	.	.	.	D	T	T	0.309	0.754	0.631	0.419	T	T	T	T	D	D	3.078	23.600	0.999	D	N	0.649	6.459	0.461	4.825	1.000	0.487	0.563	0.574	0.542	.	5.030	5.030	1.045	1.176	0.676	0.002	0.870	0.450	726	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV99421034;OCCURENCE=1(stomach)	OR8A1	310	0	161	19	0.105555555555556	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-04853	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	453	1	227	22	0.0883534136546185	TRUE	TRUE
ENSG00000165548.11	.	BCM	GRCh38.p13	chr14	77256659	77256659	+	C	C	T	Missense_Mutation	SNP	ENST00000298351.5	exon24	c.C2354T	p.A785V	exonic	ENSG00000165548.11	.	nonsynonymous SNV	ENSG00000165548.11:ENST00000298351.5:exon24:c.C2354T:p.A785V	14q24.3	C3L-04853	2.485e-05	0	0	0	0.0002	2.998e-05	0	0	rs756710566	0.20	T	T	B	B	N	N	L	T	N	0.040	T	T	T	0.038	0.200	0.043	0.405	T	T	T	T	T	T	0.808	9.471	0.993	N	N	-0.391	1.403	-0.354	1.457	0.828	0.615	0.590	0.659	0.564	.	4.840	3.880	1.299	1.026	0.599	0.018	0.376	0.109	676	.	.	.	ID=COSV53604461;OCCURENCE=1(large_intestine),1(stomach)	TMEM63C	262	0	160	25	0.135135135135135	TRUE	TRUE
ENSG00000159433.12	.	BCM	GRCh38.p13	chr15	42684817	42684817	+	T	T	A	Missense_Mutation	SNP	ENST00000290607.12	exon23	c.T3239A	p.M1080K	exonic	ENSG00000159433.12	.	nonsynonymous SNV	ENSG00000159433.12:ENST00000290607.12:exon23:c.T3239A:p.M1080K	15q15.2	C3L-04853	.	.	.	.	.	.	.	.	.	1.16	T	.	.	.	.	N	L	T	N	0.145	T	T	D	0.114	0.257	0.302	.	T	T	T	T	T	T	-0.836	0.021	0.770	N	N	-0.889	0.535	-1.103	0.373	1.000	0.615	0.654	0.659	0.492	.	5.270	-9.900	-0.626	-0.152	0.665	0.000	0.000	0.325	91	.	.	.	.	STARD9	391	0	203	34	0.143459915611814	TRUE	TRUE
ENSG00000205832.7	.	BCM	GRCh38.p13	chr16	4600282	4600282	+	G	G	A	Missense_Mutation	SNP	ENST00000444310.4	exon16	c.G3391A	p.G1131S	exonic	ENSG00000205832.7	.	nonsynonymous SNV	ENSG00000205832.7:ENST00000444310.4:exon16:c.G3391A:p.G1131S	16p13.3	C3L-04853	.	.	.	.	.	.	.	.	rs975896413	0.17	T	T	B	B	.	N	N	.	N	0.071	T	T	T	0.009	0.172	0.040	.	.	T	T	T	T	T	-0.202	0.506	0.519	N	N	-1.437	0.102	-1.454	0.126	0.004	0.581	0.590	0.576	0.542	.	3.360	-0.276	0.058	-0.240	-0.092	0.000	0.003	0.002	598	.	.	.	.	C16orf96	371	0	221	34	0.133333333333333	TRUE	NA
ENSG00000125414.19	.	BCM	GRCh38.p13	chr17	10526623	10526623	+	C	C	T	Missense_Mutation	SNP	ENST00000245503.10	exon30	c.G4163A	p.R1388H	exonic	ENSG00000125414.19	.	nonsynonymous SNV	ENSG00000125414.19:ENST00000245503.10:exon30:c.G4163A:p.R1388H	17p13.1	C3L-04853	1.647e-05	0	8.637e-05	0	0	0	0	6.056e-05	rs745754711	18.20	D	D	D	D	U	D	M	T	D	0.833	D	D	D	0.739	.	0.962	0.997	D	D	D	D	D	D	4.284	29.400	1.000	D	D	0.932	11.912	0.875	12.718	1.000	0.693	0.590	0.659	0.564	.	5.200	5.200	7.905	1.026	0.599	1.000	1.000	1.000	459	Myosin_tail	.	.	ID=COSV55432911;OCCURENCE=1(large_intestine),1(central_nervous_system),1(ovary),1(stomach),1(kidney)	MYH2	794	0	433	42	0.0884210526315789	TRUE	TRUE
ENSG00000004139.14	.	BCM	GRCh38.p13	chr17	28388351	28388351	+	C	C	T	Missense_Mutation	SNP	ENST00000585482.6	exon7	c.C1735T	p.L579F	exonic	ENSG00000004139.14	.	nonsynonymous SNV	ENSG00000004139.14:ENST00000585482.6:exon7:c.C1735T:p.L579F	17q11.2	C3L-04853	.	.	.	.	.	.	.	.	.	13.16	.	D	D	D	D	D	.	.	.	0.741	T	T	D	0.310	0.576	0.691	.	D	T	D	D	D	D	3.362	24.300	0.999	D	D	1.078	16.601	0.914	14.370	1.000	0.615	0.634	0.602	0.528	.	5.390	5.390	4.861	1.026	0.599	1.000	0.968	0.706	127	Toll/interleukin-1_receptor_homology_(TIR)_domain	.	.	.	SARM1	241	1	142	15	0.0955414012738854	TRUE	TRUE
ENSG00000171431.4	.	BCM	GRCh38.p13	chr17	40885056	40885056	+	T	T	C	Missense_Mutation	SNP	ENST00000167588.4	exon1	c.A130G	p.I44V	exonic	ENSG00000171431.4	.	nonsynonymous SNV	ENSG00000171431.4:ENST00000167588.4:exon1:c.A130G:p.I44V	17q21.2	C3L-04853	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	D	N	0.069	T	T	T	0.204	0.228	0.708	0.249	T	T	T	T	T	T	1.337	14.650	0.958	D	N	-0.318	1.570	-0.104	2.036	0.877	0.516	0.610	0.547	0.530	.	5.790	5.790	1.755	1.138	0.665	1.000	0.908	0.559	105	.	.	.	.	KRT20	520	0	300	40	0.117647058823529	TRUE	TRUE
ENSG00000104848.1	.	BCM	GRCh38.p13	chr19	49070088	49070088	+	C	C	T	Missense_Mutation	SNP	ENST00000221444.1	exon2	c.G1346A	p.G449E	exonic	ENSG00000104848.1	.	nonsynonymous SNV	ENSG00000104848.1:ENST00000221444.1:exon2:c.G1346A:p.G449E	19q13.33	C3L-04853	8.5e-06	0	0	0	0	0	0	6.847e-05	rs765895551	4.20	T	T	P	B	N	N	N	D	N	0.156	D	D	D	0.320	0.187	0.698	0.838	T	T	T	T	T	T	1.112	12.890	0.812	N	N	-0.651	0.897	-0.654	0.966	0.003	0.598	0.590	0.596	0.530	.	4.270	3.210	0.801	0.125	-0.306	0.098	0.367	0.503	867	.	.	.	.	KCNA7	158	0	101	12	0.106194690265487	TRUE	NA
ENSG00000160469.17	.	BCM	GRCh38.p13	chr19	55305556	55305556	+	C	C	G	Missense_Mutation	SNP	ENST00000309383.6	exon16	c.C1860G	p.I620M	exonic	ENSG00000160469.17	.	nonsynonymous SNV	ENSG00000160469.17:ENST00000309383.6:exon16:c.C1860G:p.I620M	19q13.42	C3L-04853	.	.	.	.	.	.	.	.	.	11.20	D	D	P	P	D	D	M	T	N	0.557	T	T	D	0.268	0.514	0.868	1.524	T	T	D	D	D	D	3.443	24.500	0.986	D	N	0.504	5.066	0.498	5.140	1.000	0.635	0.627	0.644	0.605	.	5.040	3.980	1.979	1.025	0.598	1.000	1.000	0.999	988	.	.	.	.	BRSK1	267	0	142	8	0.0533333333333333	TRUE	TRUE
ENSG00000182872.16	.	BCM	GRCh38.p13	chrX	47185142	47185142	+	C	C	T	Nonsense_Mutation	SNP	ENST00000377604.8	exon18	c.C2038T	p.R680X	exonic	ENSG00000182872.16	.	stopgain	ENSG00000182872.16:ENST00000377604.8:exon18:c.C2038T:p.R680X	Xp11.3	C3L-04853	.	.	.	.	.	.	.	.	.	5.5	.	.	.	.	D	A	.	.	.	0.793	.	.	.	.	.	.	.	.	.	D	D	.	.	5.471	34	0.998	D	.	.	.	.	.	0.995	.	.	.	.	.	5.720	2.840	0.064	0.947	0.599	0.243	0.998	0.984	404	.	.	.	ID=COSV100237880;OCCURENCE=1(ovary)	RBM10	655	0	387	27	0.0652173913043478	TRUE	TRUE
ENSG00000147206.17	.	BCM	GRCh38.p13	chrX	103077617	103077617	+	T	T	A	Missense_Mutation	SNP	ENST00000395065.8	exon18	c.A1581T	p.K527N	exonic	ENSG00000147206.17	.	nonsynonymous SNV	ENSG00000147206.17:ENST00000395065.8:exon18:c.A1581T:p.K527N	Xq22.1	C3L-04853	.	.	.	.	.	.	.	.	.	2.19	D	D	P	B	N	N	L	T	N	0.068	T	T	T	0.089	0.158	0.407	0.262	T	T	T	T	T	T	0.899	10.420	0.959	N	.	.	.	.	.	0.000	.	.	.	.	.	3.880	-1.470	-0.033	-0.173	-0.155	0.952	0.015	0.020	305	.	.	.	.	NXF3	253	0	196	12	0.0576923076923077	TRUE	TRUE
ENSG00000175718.10	.	BCM	GRCh38.p13	chrX	115189601	115189601	+	G	G	A	Missense_Mutation	SNP	ENST00000424776.5	exon1	c.G160A	p.V54I	exonic	ENSG00000175718.10	.	nonsynonymous SNV	ENSG00000175718.10:ENST00000424776.5:exon1:c.G160A:p.V54I	Xq23	C3L-04853	.	.	.	.	.	.	.	.	.	2.18	T	T	P	B	.	D	L	D	N	0.218	T	T	T	0.281	0.630	0.076	.	T	T	T	T	T	T	-0.242	0.416	0.907	N	.	.	.	.	.	0.019	.	.	.	.	.	0.690	-1.380	2.191	-1.088	-1.380	1.000	0.003	0.003	937	RNA_recognition_motif_domain	.	.	ID=COSV57759976;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	RBMXL3	465	0	278	23	0.0764119601328904	TRUE	TRUE
ENSG00000147381.11	.	BCM	GRCh38.p13	chrX	151924469	151924469	+	C	C	T	Missense_Mutation	SNP	ENST00000360243.6	exon3	c.C805T	p.R269C	exonic	ENSG00000147381.11	.	nonsynonymous SNV	ENSG00000147381.11:ENST00000360243.6:exon3:c.C805T:p.R269C	Xq28	C3L-04853	8.066e-05	0	0.0002	0	0	8.379e-05	0.0016	0	rs755062941	0.19	T	T	B	B	N	N	N	T	N	0.058	T	T	T	0.009	0.470	0.043	0.003	T	T	T	T	T	T	-0.611	0.069	0.757	N	.	.	.	.	.	0.030	.	.	.	.	.	2.370	-3.410	-2.474	-2.117	-1.019	0.000	0.000	0.001	728	MAGE_homology_domain	.	.	ID=COSV52340702;OCCURENCE=2(breast),1(large_intestine),1(NS)	MAGEA4	317	0	193	17	0.080952380952381	NA	TRUE
ENSG00000163521.16	.	BCM	GRCh38.p13	chr2	219237511	219237511	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000163521.16	ENST00000295759.12:exon16:c.1689+1G>T	.	.	2q35	C3L-04853	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.735	34	0.994	D	.	1.153	20.188	0.996	18.596	1.000	0.099	0.105	0.138	0.118	0.984	5.090	5.090	7.423	1.026	0.594	1.000	1.000	0.992	546	.	.	.	.	GLB1L	269	0	142	16	0.10126582278481	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673838	7673838	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon8:c.783-1G>A	.	.	17p13.1	C3L-04853	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.861	33	0.993	D	.	0.947	12.324	0.737	8.497	1.000	0.295	0.272	0.343	0.120	0.969	4.820	4.820	7.905	1.022	0.596	1.000	0.054	0.668	432	.	.	.	ID=COSV52729930;OCCURENCE=1(breast),1(parathyroid),1(liver),1(oesophagus),1(large_intestine),1(stomach),2(haematopoietic_and_lymphoid_tissue),6(urinary_tract),1(lung),1(upper_aerodigestive_tract)	TP53	720	0	378	48	0.112676056338028	TRUE	TRUE
ENSG00000132768.14	.	BCM	GRCh38.p13	chr1	43971856	43971856	+	C	C	A	Silent	SNP	ENST00000255108.8	exon4	c.C954A	p.A318A	exonic	ENSG00000132768.14	.	synonymous SNV	ENSG00000132768.14:ENST00000255108.8:exon4:c.C954A:p.A318A	1p34.1	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DPH2	399	0	271	35	0.11437908496732	TRUE	TRUE
ENSG00000122420.10	.	BCM	GRCh38.p13	chr1	78492887	78492887	+	C	C	A	Silent	SNP	ENST00000370757.8	exon2	c.C144A	p.I48I	exonic	ENSG00000122420.10	.	synonymous SNV	ENSG00000122420.10:ENST00000370757.8:exon2:c.C144A:p.I48I	1p31.1	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTGFR	356	1	210	14	0.0625	TRUE	TRUE
ENSG00000163060.8	.	BCM	GRCh38.p13	chr2	94871780	94871780	+	C	C	T	Silent	SNP	ENST00000295201.5	exon1	c.C201T	p.H67H	exonic	ENSG00000163060.8	.	synonymous SNV	ENSG00000163060.8:ENST00000295201.5:exon1:c.C201T:p.H67H	2q11.1	C3L-04853	.	.	.	.	.	.	.	.	rs199545713	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TEKT4	454	0	324	20	0.0581395348837209	TRUE	NA
ENSG00000113231.14	.	BCM	GRCh38.p13	chr5	77404781	77404781	+	A	A	G	Silent	SNP	ENST00000264917.10	exon12	c.A1272G	p.S424S	exonic	ENSG00000113231.14;ENSG00000284762.1	.	synonymous SNV	ENSG00000113231.14:ENST00000264917.10:exon12:c.A1272G:p.S424S,ENSG00000284762.1:ENST00000646262.1:exon14:c.A900G:p.S300S	5q13.3	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDE8B	514	0	210	12	0.0540540540540541	TRUE	NA
ENSG00000181965.6	.	BCM	GRCh38.p13	chr5	135535361	135535361	+	C	C	T	Silent	SNP	ENST00000314744.6	exon1	c.G330A	p.A110A	exonic	ENSG00000181965.6	.	synonymous SNV	ENSG00000181965.6:ENST00000314744.6:exon1:c.G330A:p.A110A	5q31.1	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEUROG1	417	0	296	43	0.126843657817109	TRUE	TRUE
ENSG00000156463.18	.	BCM	GRCh38.p13	chr5	146049105	146049105	+	T	T	C	Silent	SNP	ENST00000359120.9	exon7	c.T1182C	p.H394H	exonic	ENSG00000156463.18	.	synonymous SNV	ENSG00000156463.18:ENST00000359120.9:exon7:c.T1182C:p.H394H	5q32	C3L-04853	8.24e-06	9.614e-05	0	0	0	0	0	0	rs750545470	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SH3RF2	488	0	337	19	0.0533707865168539	TRUE	NA
ENSG00000146857.4	.	BCM	GRCh38.p13	chr7	135251813	135251813	+	C	C	A	Silent	SNP	ENST00000275764.3	exon7	c.C750A	p.A250A	exonic	ENSG00000146857.4	.	synonymous SNV	ENSG00000146857.4:ENST00000275764.3:exon7:c.C750A:p.A250A	7q33	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STRA8	392	0	272	24	0.0810810810810811	TRUE	TRUE
ENSG00000170748.7	.	BCM	GRCh38.p13	chr11	7090083	7090083	+	C	C	T	Silent	SNP	ENST00000306904.7	exon1	c.C963T	p.G321G	exonic	ENSG00000170748.7	.	synonymous SNV	ENSG00000170748.7:ENST00000306904.7:exon1:c.C963T:p.G321G	11p15.4	C3L-04853	2.698e-05	0	0.0002	0	0	0	0	6.158e-05	rs561845229	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBMXL2	188	0	95	6	0.0594059405940594	TRUE	NA
ENSG00000149452.16	.	BCM	GRCh38.p13	chr11	62993570	62993570	+	C	C	T	Silent	SNP	ENST00000336232.7	exon10	c.G1383A	p.P461P	exonic	ENSG00000149452.16	.	synonymous SNV	ENSG00000149452.16:ENST00000336232.7:exon10:c.G1383A:p.P461P	11q12.3	C3L-04853	7.429e-05	0	0.0004	0.0001	0	4.502e-05	0	0	rs765180492	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC22A8	172	0	85	18	0.174757281553398	TRUE	NA
ENSG00000120457.12	.	BCM	GRCh38.p13	chr11	128912047	128912047	+	C	C	T	Silent	SNP	ENST00000529694.6	exon2	c.C774T	p.N258N	exonic	ENSG00000120457.12	.	synonymous SNV	ENSG00000120457.12:ENST00000529694.6:exon2:c.C774T:p.N258N	11q24.3	C3L-04853	.	.	.	.	.	.	.	.	rs377321127	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57966578;OCCURENCE=1(stomach),1(prostate)	KCNJ5	156	0	107	8	0.0695652173913043	TRUE	TRUE
ENSG00000211899.10	.	BCM	GRCh38.p13	chr14	105854625	105854625	+	G	G	A	Silent	SNP	ENST00000637539.2	exon4	c.C1080T	p.D360D	exonic	ENSG00000211899.10	.	synonymous SNV	ENSG00000211899.10:ENST00000637539.2:exon4:c.C1080T:p.D360D	14q32.33	C3L-04853	7.961e-05	0	0	0.0005	0	3.161e-05	0	0.0002	rs374663321	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHM	904	0	563	62	0.0992	TRUE	NA
ENSG00000141506.13	.	BCM	GRCh38.p13	chr17	8884758	8884758	+	G	G	A	Silent	SNP	ENST00000447110.5	exon15	c.C2154T	p.I718I	exonic	ENSG00000141506.13	.	synonymous SNV	ENSG00000141506.13:ENST00000447110.5:exon15:c.C2154T:p.I718I	17p13.1	C3L-04853	8.275e-06	0	0	0	0	0	0	6.066e-05	rs148443913	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52650541;OCCURENCE=2(skin)	PIK3R5	308	0	194	26	0.118181818181818	TRUE	TRUE
ENSG00000173821.19	.	BCM	GRCh38.p13	chr17	80313071	80313071	+	G	G	T	Silent	SNP	ENST00000508628.6	exon16	c.G2862T	p.G954G	exonic	ENSG00000173821.19	.	synonymous SNV	ENSG00000173821.19:ENST00000508628.6:exon16:c.G2862T:p.G954G	17q25.3	C3L-04853	1.651e-05	9.623e-05	8.643e-05	0	0	0	0	0	rs373595025	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF213	722	1	467	25	0.0508130081300813	TRUE	NA
ENSG00000160111.13	.	BCM	GRCh38.p13	chr19	16914738	16914738	+	G	G	A	Silent	SNP	ENST00000443236.6	exon28	c.C3705T	p.A1235A	exonic	ENSG00000160111.13	.	synonymous SNV	ENSG00000160111.13:ENST00000443236.6:exon28:c.C3705T:p.A1235A	19p13.11	C3L-04853	0.0010	0.0001	8.688e-05	0.0012	0	0.0003	0	0.0054	rs200423977	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV71597583;OCCURENCE=1(stomach)	CPAMD8	461	1	381	21	0.0522388059701493	TRUE	NA
ENSG00000160469.17	.	BCM	GRCh38.p13	chr19	55306332	55306332	+	C	C	T	Silent	SNP	ENST00000309383.6	exon17	c.C1971T	p.F657F	exonic	ENSG00000160469.17	.	synonymous SNV	ENSG00000160469.17:ENST00000309383.6:exon17:c.C1971T:p.F657F	19q13.42	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58670721;OCCURENCE=2(skin)	BRSK1	649	0	381	41	0.0971563981042654	TRUE	TRUE
ENSG00000156282.5	.	BCM	GRCh38.p13	chr21	30166549	30166549	+	G	G	A	Silent	SNP	ENST00000286808.5	exon1	c.C69T	p.A23A	exonic	ENSG00000156282.5	.	synonymous SNV	ENSG00000156282.5:ENST00000286808.5:exon1:c.C69T:p.A23A	21q21.3	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLDN17	241	0	173	25	0.126262626262626	TRUE	TRUE
ENSG00000120500.18	.	BCM	GRCh38.p13	chrX	70276212	70276212	+	G	G	C	Silent	SNP	ENST00000307959.9	exon6	c.G276C	p.G92G	exonic	ENSG00000120500.18	.	synonymous SNV	ENSG00000120500.18:ENST00000307959.9:exon6:c.G276C:p.G92G	Xq13.1	C3L-04853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARR3	463	0	280	17	0.0572390572390572	TRUE	TRUE
ENSG00000078808.18	.	BCM	GRCh38.p13	chr1	1218975	1218975	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000078808.18	.	.	.	1p36.33	C3L-04853	8.598e-06	0	0	0	0	1.577e-05	0	0	rs376779621	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SDF4	262	0	211	27	0.113445378151261	TRUE	NA
ENSG00000136560.14	.	BCM	GRCh38.p13	chr2	161179643	161179643	+	A	A	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000136560.14	ENST00000392749.7:c.-20A>T	.	.	2q24.2	C3L-04853	.	.	.	.	.	.	.	.	.	7.14	D	D	.	.	.	D	.	.	N	0.871	T	T	T	0.266	0.409	0.442	.	.	T	D	T	D	T	2.163	20.600	0.994	D	D	0.477	4.861	0.574	5.916	1.000	0.719	0.723	0.710	0.714	.	6.040	6.040	7.179	1.312	0.756	1.000	1.000	0.995	369	.	.	.	.	TANK	176	0	93	6	0.0606060606060606	TRUE	TRUE
ENSG00000254921.1	.	BCM	GRCh38.p13	chr11	8038922	8038922	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000254921.1	.	.	.	11p15.4	C3L-04853	.	.	.	.	.	.	.	.	rs144469939	1.18	T	T	B	B	N	N	.	D	N	0.222	T	T	T	0.260	.	0.680	0.205	T	.	T	T	T	T	-1.091	0.004	0.859	N	N	-1.598	0.056	-1.697	0.052	1.000	0.497	0.590	0.547	0.542	.	4.370	-8.750	-2.819	-1.828	-0.886	0.019	0.416	0.974	883	.	.	.	ID=COSV59491507;OCCURENCE=1(skin)	AC116456.1	254	0	181	13	0.0670103092783505	TRUE	NA
ENSG00000215612.8	.	BCM	GRCh38.p13	chr4	8871284	8871284	+	C	C	T	Missense_Mutation	SNP	ENST00000400677.5	exon1	c.G331A	p.G111R	exonic	ENSG00000215612.8	.	nonsynonymous SNV	ENSG00000215612.8:ENST00000400677.5:exon1:c.G331A:p.G111R	4p16.1	C3L-02115	.	.	.	.	.	.	.	.	.	7.19	D	D	B	B	.	N	L	D	D	0.457	T	T	D	0.205	0.323	0.889	1.078	D	T	T	T	D	T	2.341	21.800	0.993	N	N	-0.688	0.833	-0.651	0.970	0.995	0.598	0.578	0.607	0.639	.	2.760	1.860	0.516	0.934	0.487	0.974	0.819	0.441	.	.	.	.	.	HMX1	136	0	232	13	0.0530612244897959	TRUE	TRUE
ENSG00000266524.3	.	BCM	GRCh38.p13	chr10	47300938	47300938	+	G	G	A	Missense_Mutation	SNP	ENST00000580279.2	exon1	c.G287A	p.G96D	exonic	ENSG00000266524.3	.	nonsynonymous SNV	ENSG00000266524.3:ENST00000580279.2:exon1:c.G287A:p.G96D	10q11.22	C3L-02115	.	.	.	.	.	.	.	.	.	3.5	.	T	.	.	.	.	.	T	.	0.796	.	.	.	.	.	.	.	.	D	.	.	.	D	4.353	30	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	6.999	1.176	0.676	1.000	0.997	0.978	976	.	.	.	.	GDF10	57	0	119	8	0.062992125984252	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02115	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	333	0	452	45	0.0905432595573441	TRUE	TRUE
ENSG00000136011.15	.	BCM	GRCh38.p13	chr12	103620484	103620484	+	G	G	-	Frame_Shift_Del	NA	ENST00000388887.7	exon4	c.348delG	p.S118Hfs*58	exonic	ENSG00000136011.15	.	frameshift deletion	ENSG00000136011.15:ENST00000388887.7:exon4:c.348delG:p.S118Hfs*58	12q23.3	C3L-02115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STAB2	177	0	293	23	0.0727848101265823	NA	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51048816	51048816	+	G	G	T	Missense_Mutation	SNP	ENST00000342988.8	exon3	c.G380T	p.C127F	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon3:c.G380T:p.C127F	18q21.2	C3L-02115	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.987	D	D	D	0.989	0.933	0.993	3.576	D	D	D	D	D	D	4.193	28.600	0.993	D	D	1.040	15.228	0.962	16.690	1.000	0.707	0.725	0.663	0.714	.	5.320	5.320	9.998	1.176	0.618	1.000	1.000	1.000	680	MAD_homology_1,_Dwarfin-type;MAD_homology,_MH1	.	.	ID=COSV61684333;OCCURENCE=1(large_intestine),1(pancreas),1(lung),1(small_intestine)	SMAD4	357	0	448	15	0.0323974082073434	TRUE	TRUE
ENSG00000131264.3	.	BCM	GRCh38.p13	chrX	73447683	73447683	+	G	G	A	Missense_Mutation	SNP	ENST00000373514.2	exon1	c.G430A	p.A144T	exonic	ENSG00000131264.3	.	nonsynonymous SNV	ENSG00000131264.3:ENST00000373514.2:exon1:c.G430A:p.A144T	Xq13.2	C3L-02115	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	L	T	N	0.043	T	T	T	0.015	0.379	0.616	0.109	T	T	T	T	T	T	-0.561	0.088	0.854	N	.	.	.	.	.	0.999	.	.	.	.	.	2.180	-2.080	-0.786	-1.859	-2.308	0.000	0.000	0.001	146	Caudal-like_activation_domain	.	.	.	CDX4	53	0	86	7	0.0752688172043011	TRUE	TRUE
ENSG00000185298.13	.	BCM	GRCh38.p13	chr17	81670454	81670454	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000185298.13	ENST00000329214.13:exon3:c.497+1G>A	.	.	17q25.3	C3L-02115	7.103e-05	0.0001	0	0	0	0.0001	0	0	rs201831605	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.546	34	0.995	D	.	0.967	12.906	0.786	9.733	1.000	0.257	0.272	0.172	0.118	0.964	4.670	4.670	3.577	1.075	0.676	1.000	0.993	0.974	.	.	.	.	ID=COSV61303151;OCCURENCE=1(skin)	CCDC137	151	0	178	11	0.0582010582010582	TRUE	TRUE
ENSG00000116544.12	.	BCM	GRCh38.p13	chr1	34868729	34868729	+	G	G	A	Silent	SNP	ENST00000373347.6	exon9	c.C2361T	p.R787R	exonic	ENSG00000116544.12	.	synonymous SNV	ENSG00000116544.12:ENST00000373347.6:exon9:c.C2361T:p.R787R	1p34.3	C3L-02115	4.283e-05	0	0	0.0001	0	4.69e-05	0	6.131e-05	rs755715413	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DLGAP3	194	0	282	15	0.0505050505050505	TRUE	NA
ENSG00000177679.16	.	BCM	GRCh38.p13	chr7	76267420	76267420	+	G	G	A	Silent	SNP	ENST00000611745.2	exon11	c.G993A	p.A331A	exonic	ENSG00000177679.16	.	synonymous SNV	ENSG00000177679.16:ENST00000611745.2:exon11:c.G993A:p.A331A	7q11.23	C3L-02115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SRRM3	72	0	149	11	0.06875	TRUE	TRUE
ENSG00000005379.17	.	BCM	GRCh38.p13	chr17	58305603	58305603	+	G	G	A	Silent	SNP	ENST00000343736.9	exon28	c.C5298T	p.P1766P	exonic	ENSG00000005379.17	.	synonymous SNV	ENSG00000005379.17:ENST00000343736.9:exon28:c.C5298T:p.P1766P	17q22	C3L-02115	1.009e-05	0	0	0	0	0	0	0.0001	rs549004710	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TSPOAP1	27	0	53	4	0.0701754385964912	TRUE	NA
ENSG00000130477.15	.	BCM	GRCh38.p13	chr19	17672495	17672495	+	G	G	A	Silent	SNP	ENST00000519716.6	exon4	c.C153T	p.F51F	exonic	ENSG00000130477.15	.	synonymous SNV	ENSG00000130477.15:ENST00000519716.6:exon4:c.C153T:p.F51F	19p13.11	C3L-02115	0.0006	0.0002	0.0015	0.0001	0	0.0008	0	0	rs202115985	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UNC13A	136	0	199	13	0.0613207547169811	TRUE	NA
ENSG00000213996.13	.	BCM	GRCh38.p13	chr19	19264724	19264724	+	G	G	A	Silent	SNP	ENST00000389363.5	exon10	c.C1074T	p.P358P	exonic	ENSG00000213996.13	.	synonymous SNV	ENSG00000213996.13:ENST00000389363.5:exon10:c.C1074T:p.P358P	19p13.11	C3L-02115	0.0001	0	0.0006	0	0	7.702e-05	0	8.085e-05	rs199962010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TM6SF2	93	0	104	9	0.079646017699115	TRUE	NA
ENSG00000267041.6	.	BCM	GRCh38.p13	chr19	36750755	36750755	+	G	G	T	Silent	SNP	ENST00000591344.2	exon5	c.C285A	p.I95I	exonic	ENSG00000267041.6	.	synonymous SNV	ENSG00000267041.6:ENST00000591344.2:exon5:c.C285A:p.I95I	19q13.12	C3L-02115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF850	94	0	135	8	0.0559440559440559	TRUE	TRUE
ENSG00000133454.16	.	BCM	GRCh38.p13	chr22	25955355	25955355	+	C	C	T	Silent	SNP	ENST00000335473.12	exon39	c.C6147T	p.C2049C	exonic	ENSG00000133454.16	.	synonymous SNV	ENSG00000133454.16:ENST00000335473.12:exon39:c.C6147T:p.C2049C	22q12.1	C3L-02115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO18B	112	0	165	11	0.0625	TRUE	TRUE
ENSG00000130540.14	.	BCM	GRCh38.p13	chr22	43862371	43862371	+	G	G	A	Silent	SNP	ENST00000330884.9	exon1	c.C12T	p.S4S	exonic	ENSG00000130540.14	.	synonymous SNV	ENSG00000130540.14:ENST00000330884.9:exon1:c.C12T:p.S4S	22q13.31	C3L-02115	8.79e-06	0	0	0	0	1.615e-05	0	0	rs760024551	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SULT4A1	144	0	213	13	0.0575221238938053	TRUE	NA
ENSG00000267496.4	.	BCM	GRCh38.p13	chr17	43917553	43917553	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000267496.4	.	.	.	17q21.31	C3L-02115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM215A	169	0	298	16	0.0509554140127389	TRUE	NA
ENSG00000065717.15	.	BCM	GRCh38.p13	chr19	3006114	3006114	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000065717.15	.	.	.	19p13.3	C3L-02115	8.849e-06	0	8.8e-05	0	0	0	0	0	rs770741631	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53581306;OCCURENCE=2(large_intestine)	TLE2	280	0	265	15	0.0535714285714286	TRUE	NA
ENSG00000198793.13	.	BCM	GRCh38.p13	chr1	11127710	11127710	+	C	C	T	Missense_Mutation	SNP	ENST00000361445.9	exon44	c.G6130A	p.V2044M	exonic	ENSG00000198793.13	.	nonsynonymous SNV	ENSG00000198793.13:ENST00000361445.9:exon44:c.G6130A:p.V2044M	1p36.22	C3L-02701	.	.	.	.	.	.	.	.	rs868627779	18.20	D	D	D	D	D	D	M	T	D	0.552	D	D	D	0.361	0.685	0.780	2.399	D	T	D	D	D	D	3.852	26.100	0.999	D	D	0.931	11.889	0.899	13.730	1.000	0.707	0.725	0.725	0.714	.	5.800	5.800	7.539	1.026	0.599	1.000	0.997	0.995	375	FKBP12-rapamycin_binding_domain	.	.	.	MTOR	176	0	246	27	0.0989010989010989	TRUE	NA
ENSG00000117245.12	.	BCM	GRCh38.p13	chr1	20666300	20666300	+	C	C	T	Missense_Mutation	SNP	ENST00000247986.2	exon14	c.G2825A	p.R942Q	exonic	ENSG00000117245.12	.	nonsynonymous SNV	ENSG00000117245.12:ENST00000247986.2:exon14:c.G2825A:p.R942Q	1p36.12	C3L-02701	8.237e-06	0	0	0	0	1.498e-05	0	0	rs146340669	12.19	D	D	D	D	.	D	M	T	N	0.441	D	T	D	0.276	.	0.867	1.320	T	T	T	T	D	D	3.551	24.900	0.999	D	D	0.475	4.850	0.426	4.551	1.000	0.706	0.588	0.710	0.527	.	5.750	5.750	3.876	1.026	0.599	0.998	0.350	0.080	765	.	.	.	.	KIF17	646	1	1033	60	0.0548947849954254	TRUE	NA
ENSG00000179397.18	.	BCM	GRCh38.p13	chr1	244477577	244477577	+	T	T	C	Missense_Mutation	SNP	ENST00000366534.9	exon3	c.T151C	p.W51R	exonic	ENSG00000179397.18	.	nonsynonymous SNV	ENSG00000179397.18:ENST00000366534.9:exon3:c.T151C:p.W51R	1q44	C3L-02701	.	.	.	.	.	.	.	.	.	12.18	D	D	D	D	D	D	.	T	D	0.873	T	T	D	0.474	0.563	0.675	0.917	.	T	D	D	D	T	3.767	25.700	0.995	D	N	0.534	5.307	0.483	5.009	0.016	0.554	0.588	0.547	0.568	.	4.160	4.160	2.823	1.138	0.665	1.000	0.735	0.986	964	.	.	.	.	CATSPERE	144	1	216	24	0.1	TRUE	NA
ENSG00000049323.16	.	BCM	GRCh38.p13	chr2	33273766	33273766	+	C	C	A	Missense_Mutation	SNP	ENST00000404816.7	exon16	c.C2728A	p.Q910K	exonic	ENSG00000049323.16	.	nonsynonymous SNV	ENSG00000049323.16:ENST00000404816.7:exon16:c.C2728A:p.Q910K	2p22.3	C3L-02701	.	.	.	.	.	.	.	.	.	5.19	T	T	B	B	.	N	L	D	N	0.294	D	D	D	0.462	0.625	0.270	0.172	T	T	T	T	T	T	2.322	21.700	0.955	D	N	-0.145	2.036	0.032	2.473	1.000	0.693	0.610	0.659	0.646	.	5.520	5.520	3.120	1.008	0.549	1.000	0.993	0.913	849	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	LTBP1	129	0	188	48	0.203389830508475	TRUE	TRUE
ENSG00000155052.14	.	BCM	GRCh38.p13	chr2	124903004	124903004	+	G	G	A	Missense_Mutation	SNP	ENST00000431078.1	exon22	c.G3556A	p.A1186T	exonic	ENSG00000155052.14	.	nonsynonymous SNV	ENSG00000155052.14:ENST00000431078.1:exon22:c.G3556A:p.A1186T	2q14.3	C3L-02701	0.0033	0.0372	0.0012	0.0002	0	5.607e-05	0.0014	0.0001	rs114400050	5.19	T	T	P	B	N	D	M	D	N	0.248	D	T	.	0.340	.	0.706	0.090	T	T	T	T	T	T	1.833	17.980	0.991	D	N	0.096	2.870	0.037	2.492	0.001	0.487	0.574	0.574	0.564	.	5.500	4.600	4.274	1.176	0.676	0.997	0.025	0.041	910	Laminin_G_domain	.	.	.	CNTNAP5	164	0	239	19	0.0736434108527132	TRUE	NA
ENSG00000182263.14	.	BCM	GRCh38.p13	chr2	163610683	163610683	+	C	C	T	Missense_Mutation	SNP	ENST00000333129.4	exon3	c.G1149A	p.M383I	exonic	ENSG00000182263.14	.	nonsynonymous SNV	ENSG00000182263.14:ENST00000333129.4:exon3:c.G1149A:p.M383I	2q24.3	C3L-02701	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	D	D	L	D	N	0.190	D	D	T	0.359	0.272	0.452	0.235	T	T	T	T	T	D	1.856	18.150	0.978	D	N	0.073	2.782	0.286	3.636	1.000	0.563	0.574	0.609	0.636	.	6.040	6.040	4.010	1.026	0.599	1.000	0.998	1.000	860	.	.	.	.	FIGN	321	0	474	34	0.0669291338582677	TRUE	TRUE
ENSG00000127831.11	.	BCM	GRCh38.p13	chr2	218432934	218432934	+	C	C	T	Missense_Mutation	SNP	ENST00000248444.10	exon13	c.C1483T	p.R495C	exonic	ENSG00000127831.11	.	nonsynonymous SNV	ENSG00000127831.11:ENST00000248444.10:exon13:c.C1483T:p.R495C	2q35	C3L-02701	4.95e-05	0	0.0004	0	0	1.5e-05	0	0	rs768874816	6.20	D	D	B	B	N	N	L	T	D	0.295	T	T	T	0.084	0.762	0.564	0.256	T	D	T	T	T	T	3.108	23.600	0.990	D	D	-0.300	1.614	-0.237	1.699	0.543	0.615	0.574	0.659	0.542	.	4.660	2.860	3.799	1.026	0.599	0.590	0.600	0.970	924	.	.	.	ID=COSV50288224;OCCURENCE=1(ovary),1(prostate)	VIL1	173	0	341	27	0.0733695652173913	NA	TRUE
ENSG00000144668.12	.	BCM	GRCh38.p13	chr3	37519287	37519287	+	A	A	T	Missense_Mutation	SNP	ENST00000264741.10	exon11	c.A1169T	p.D390V	exonic	ENSG00000144668.12	.	nonsynonymous SNV	ENSG00000144668.12:ENST00000264741.10:exon11:c.A1169T:p.D390V	3p22.2	C3L-02701	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	D	D	M	T	D	0.733	T	T	D	0.457	0.564	0.647	0.887	T	D	T	T	D	D	4.573	32	0.994	D	D	0.876	10.440	0.838	11.329	1.000	0.638	0.590	0.653	0.542	.	5.860	5.860	9.271	1.312	0.756	1.000	0.953	0.981	647	.	.	.	.	ITGA9	531	0	741	74	0.0907975460122699	TRUE	TRUE
ENSG00000177494.6	.	BCM	GRCh38.p13	chr3	111594045	111594045	+	G	G	A	Missense_Mutation	SNP	ENST00000317012.5	exon2	c.C157T	p.R53W	exonic	ENSG00000177494.6	.	nonsynonymous SNV	ENSG00000177494.6:ENST00000317012.5:exon2:c.C157T:p.R53W	3q13.13	C3L-02701	.	.	.	.	.	.	.	.	rs967555755	6.19	D	D	D	P	U	D	L	.	D	0.287	T	T	T	0.198	.	0.210	0.028	T	T	T	T	D	T	1.643	16.650	0.999	N	N	-0.290	1.639	-0.409	1.356	1.000	0.487	0.492	0.574	0.542	.	3.560	1.540	-0.326	1.006	0.676	0.000	0.072	0.056	694	Zinc_finger,_BED-type	.	.	.	ZBED2	218	0	333	34	0.0926430517711172	TRUE	NA
ENSG00000161217.12	.	BCM	GRCh38.p13	chr3	196257853	196257853	+	A	A	G	Missense_Mutation	SNP	ENST00000431016.6	exon3	c.T152C	p.I51T	exonic	ENSG00000161217.12	.	nonsynonymous SNV	ENSG00000161217.12:ENST00000431016.6:exon3:c.T152C:p.I51T	3q29	C3L-02701	1.654e-05	0	0	0	0.0002	1.501e-05	0	0	rs780253017	4.19	T	T	B	B	D	D	N	.	N	0.604	T	T	T	0.191	0.369	0.597	0.035	T	T	T	T	T	T	2.209	20.900	0.947	D	D	-0.147	2.031	0.116	2.801	1.000	0.732	0.744	0.710	0.714	.	5.950	5.950	6.148	1.312	0.756	1.000	1.000	0.998	754	.	.	.	.	PCYT1A	165	0	252	23	0.0836363636363636	TRUE	NA
ENSG00000170871.12	.	BCM	GRCh38.p13	chr4	6858488	6858488	+	C	C	T	Missense_Mutation	SNP	ENST00000307659.6	exon6	c.C500T	p.A167V	exonic	ENSG00000170871.12	.	nonsynonymous SNV	ENSG00000170871.12:ENST00000307659.6:exon6:c.C500T:p.A167V	4p16.1	C3L-02701	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	D	D	L	.	N	0.119	T	T	T	0.207	0.172	0.117	0.719	T	T	T	T	D	D	3.523	24.800	0.999	D	N	0.576	5.687	0.617	6.442	1.000	0.732	0.709	0.744	0.684	.	5.560	5.560	4.010	1.026	0.599	1.000	1.000	0.994	681	.	.	.	.	KIAA0232	157	0	280	16	0.0540540540540541	TRUE	TRUE
ENSG00000145244.12	.	BCM	GRCh38.p13	chr4	47665048	47665048	+	G	G	A	Missense_Mutation	SNP	ENST00000273857.9	exon11	c.C1573T	p.H525Y	exonic	ENSG00000145244.12	.	nonsynonymous SNV	ENSG00000145244.12:ENST00000273857.9:exon11:c.C1573T:p.H525Y	4p12	C3L-02701	0.0005	0	0.0053	0	0	0	0	0	rs527634306	5.20	T	D	B	B	D	N	N	T	N	0.226	T	T	D	0.232	0.813	0.836	0.092	T	T	T	T	T	T	2.452	22.300	0.346	D	D	-0.519	1.140	-0.398	1.375	0.005	0.549	0.590	0.547	0.616	.	5.250	4.420	5.115	-0.129	-0.679	1.000	0.036	0.002	448	Frizzled_domain	.	.	.	CORIN	118	0	178	15	0.077720207253886	TRUE	NA
ENSG00000164318.18	.	BCM	GRCh38.p13	chr5	38418114	38418114	+	G	G	A	Missense_Mutation	SNP	ENST00000354891.7	exon12	c.G1543A	p.A515T	exonic	ENSG00000164318.18	.	nonsynonymous SNV	ENSG00000164318.18:ENST00000354891.7:exon12:c.G1543A:p.A515T	5p13.1	C3L-02701	8.241e-06	0	0	0	0	0	0	6.058e-05	rs773215630	6.20	T	D	D	P	N	D	L	T	N	0.310	T	T	D	0.349	0.461	0.739	0.122	T	T	T	T	T	D	2.693	22.800	0.999	D	N	0.082	2.815	0.053	2.551	1.000	0.554	0.590	0.602	0.613	.	5.780	3.040	2.389	1.172	0.671	0.996	0.974	0.987	878	Laminin_G_domain	.	.	ID=COSV59306350;OCCURENCE=2(lung),1(small_intestine),1(endometrium)	EGFLAM	175	0	301	55	0.154494382022472	TRUE	TRUE
ENSG00000186952.15	.	BCM	GRCh38.p13	chr5	110568476	110568476	+	G	G	A	Nonsense_Mutation	SNP	ENST00000455884.7	exon11	c.C1426T	p.R476X	exonic	ENSG00000186952.15	.	stopgain	ENSG00000186952.15:ENST00000455884.7:exon11:c.C1426T:p.R476X	5q22.1	C3L-02701	4.486e-05	0	0	0	0	0	0	0.0001	rs148652027	3.6	.	.	.	.	N	A	.	.	.	0.357	.	.	.	.	.	.	.	.	.	D	D	.	.	6.170	35	0.962	N	N	0.279	3.672	-0.062	2.158	0.000	0.554	0.588	0.618	0.564	.	5.730	2.840	1.224	1.176	0.671	0.098	0.051	0.115	878	.	.	.	ID=COSV70268581;OCCURENCE=1(large_intestine)	TMEM232	122	0	179	10	0.0529100529100529	TRUE	TRUE
ENSG00000111859.17	.	BCM	GRCh38.p13	chr6	11185190	11185190	+	C	C	T	Missense_Mutation	SNP	ENST00000379446.10	exon7	c.G2477A	p.R826H	exonic	ENSG00000111859.17	.	nonsynonymous SNV	ENSG00000111859.17:ENST00000379446.10:exon7:c.G2477A:p.R826H	6p24.2	C3L-02701	1.65e-05	0	0	0	0.0003	0	0	0	rs758066091	1.20	T	T	B	B	N	N	N	T	N	0.049	T	T	T	0.075	0.351	0.484	0.263	T	T	T	T	T	D	2.179	20.700	0.996	N	N	-0.271	1.686	-0.058	2.170	1.000	0.707	0.725	0.609	0.711	.	6.170	5.300	0.258	1.026	0.599	0.521	0.998	0.999	713	CAS_family,_C-terminal	.	.	.	NEDD9	186	0	266	31	0.104377104377104	TRUE	NA
ENSG00000124721.18	.	BCM	GRCh38.p13	chr6	38909604	38909604	+	G	G	T	Missense_Mutation	SNP	ENST00000359357.7	exon63	c.G8949T	p.R2983S	exonic	ENSG00000124721.18	.	nonsynonymous SNV	ENSG00000124721.18:ENST00000359357.7:exon63:c.G8949T:p.R2983S	6p21.2	C3L-02701	.	.	.	.	.	.	.	.	.	7.19	D	.	B	B	N	D	L	T	D	0.378	T	T	T	0.077	0.468	0.558	0.144	T	T	T	T	D	D	2.256	21.300	0.995	D	D	-0.051	2.334	0.084	2.669	1.000	0.549	0.574	0.574	0.616	.	5.600	5.600	1.237	0.228	0.676	0.983	0.246	0.156	682	Dynein_heavy_chain,_AAA_module_D4	.	.	.	DNAH8	452	0	728	45	0.0582147477360931	TRUE	TRUE
ENSG00000164418.20	.	BCM	GRCh38.p13	chr6	101889652	101889652	+	G	G	T	Missense_Mutation	SNP	ENST00000421544.6	exon14	c.G1537T	p.A513S	exonic	ENSG00000164418.20	.	nonsynonymous SNV	ENSG00000164418.20:ENST00000421544.6:exon14:c.G1537T:p.A513S	6q16.3	C3L-02701	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.832	T	T	D	0.574	0.915	0.722	2.089	D	D	D	T	D	D	4.156	28.200	0.998	D	D	0.997	13.824	0.958	16.465	1.000	0.554	0.574	0.618	0.564	.	5.600	5.600	10.003	1.176	0.676	1.000	1.000	0.998	916	Ionotropic_glutamate_receptor,_L-glutamate_and_glycine-binding_domain;Ionotropic_glutamate_receptor	.	.	.	GRIK2	178	3	252	15	0.0561797752808989	TRUE	NA
ENSG00000118515.11	.	BCM	GRCh38.p13	chr6	134172731	134172731	+	C	C	T	Missense_Mutation	SNP	ENST00000237305.11	exon7	c.G593A	p.R198Q	exonic	ENSG00000118515.11	.	nonsynonymous SNV	ENSG00000118515.11:ENST00000237305.11:exon7:c.G593A:p.R198Q	6q23.2	C3L-02701	8.254e-06	0	0	0	0	0	0	6.078e-05	rs775999779	15.20	D	D	D	D	D	D	N	T	D	0.721	T	T	D	0.563	0.660	0.865	1.899	D	T	D	D	D	D	4.431	31	1.000	D	D	0.514	5.144	0.591	6.107	1.000	0.707	0.537	0.725	0.658	.	6.030	5.160	7.905	1.026	0.599	1.000	1.000	0.999	821	Protein_kinase_domain	.	.	.	SGK1	287	0	455	41	0.0826612903225806	TRUE	TRUE
ENSG00000128591.15	.	BCM	GRCh38.p13	chr7	128850048	128850048	+	C	C	T	Missense_Mutation	SNP	ENST00000325888.12	exon31	c.C5272T	p.R1758W	exonic	ENSG00000128591.15	.	nonsynonymous SNV	ENSG00000128591.15:ENST00000325888.12:exon31:c.C5272T:p.R1758W	7q32.1	C3L-02701	0.0005	0.0006	0.0015	0	0	0.0001	0	0.0010	rs369187211	5.20	T	D	B	B	N	D	N	D	N	0.474	T	T	D	0.296	.	0.571	0.289	T	T	T	T	T	T	1.918	18.630	0.992	D	N	-0.568	1.046	-0.462	1.264	1.000	0.707	0.588	0.723	0.714	.	3.720	3.720	1.338	1.026	0.599	0.611	0.534	0.492	587	.	.	.	.	FLNC	230	0	412	58	0.123404255319149	TRUE	NA
ENSG00000137573.14	.	BCM	GRCh38.p13	chr8	69603260	69603260	+	C	C	A	Missense_Mutation	SNP	ENST00000402687.9	exon11	c.C1130A	p.P377H	exonic	ENSG00000137573.14	.	nonsynonymous SNV	ENSG00000137573.14:ENST00000402687.9:exon11:c.C1130A:p.P377H	8q13.3	C3L-02701	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.905	D	D	D	0.718	0.678	0.220	1.076	T	D	D	D	D	D	3.890	26.300	0.997	D	D	1.018	14.482	0.985	17.959	1.000	0.707	0.563	0.616	0.714	.	6.170	6.170	7.905	1.026	0.599	1.000	0.959	0.997	904	.	.	.	ID=COSV52675160;OCCURENCE=1(liver)	SULF1	368	1	546	102	0.157407407407407	TRUE	TRUE
ENSG00000107104.19	.	BCM	GRCh38.p13	chr9	712624	712624	+	T	T	G	Missense_Mutation	SNP	ENST00000619269.4	exon4	c.T1858G	p.L620V	exonic	ENSG00000107104.19	.	nonsynonymous SNV	ENSG00000107104.19:ENST00000619269.4:exon4:c.T1858G:p.L620V	9p24.3	C3L-02701	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.114	T	T	T	0.052	0.147	0.067	.	T	T	T	T	T	T	0.612	7.625	0.903	N	N	-0.720	0.779	-0.712	0.882	1.000	0.706	0.590	0.710	0.714	.	5.960	-1.690	-0.354	0.196	0.663	0.000	1.000	0.999	728	.	.	.	.	KANK1	358	0	456	50	0.0988142292490119	TRUE	TRUE
ENSG00000178919.9	.	BCM	GRCh38.p13	chr9	97855022	97855022	+	G	G	A	Missense_Mutation	SNP	ENST00000375123.5	exon1	c.G1108A	p.V370M	exonic	ENSG00000178919.9	.	nonsynonymous SNV	ENSG00000178919.9:ENST00000375123.5:exon1:c.G1108A:p.V370M	9q22.33	C3L-02701	.	.	.	.	.	.	.	.	.	12.20	D	T	D	P	U	D	M	D	N	0.095	D	D	D	0.418	0.198	0.910	.	T	T	D	D	D	T	3.501	24.700	0.998	D	N	0.195	3.282	0.182	3.095	1.000	0.598	0.563	0.607	0.639	.	4.780	3.860	2.682	1.164	0.662	0.998	0.998	0.962	685	.	.	.	ID=COSV100909942;OCCURENCE=1(endometrium)	FOXE1	733	1	1073	90	0.0773860705073087	TRUE	TRUE
ENSG00000184925.12	.	BCM	GRCh38.p13	chr9	136952382	136952382	+	G	G	A	Missense_Mutation	SNP	ENST00000371633.8	exon1	c.G55A	p.A19T	exonic	ENSG00000184925.12	.	nonsynonymous SNV	ENSG00000184925.12:ENST00000371633.8:exon1:c.G55A:p.A19T	9q34.3	C3L-02701	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.137	T	T	T	0.059	0.303	0.175	0.106	T	T	T	T	T	T	1.555	16.090	0.848	N	N	-0.988	0.417	-0.947	0.557	0.999	0.554	0.588	0.604	0.613	.	3.880	2.950	1.140	-0.262	0.676	0.002	0.002	0.006	900	.	.	.	.	LCN12	330	1	624	60	0.087719298245614	TRUE	TRUE
ENSG00000263761.3	.	BCM	GRCh38.p13	chr10	47322756	47322756	+	C	C	T	Nonsense_Mutation	SNP	ENST00000581492.3	exon1	c.C88T	p.R30X	exonic	ENSG00000263761.3	.	stopgain	ENSG00000263761.3:ENST00000581492.3:exon1:c.C88T:p.R30X	10q11.22	C3L-02701	9.168e-06	0.0001	0	0	0	0	0	0	rs782274691	0.1	.	.	.	.	.	.	.	.	.	0.379	.	.	.	.	.	.	.	.	.	.	.	.	.	4.885	33	.	.	N	.	.	.	.	.	.	.	.	.	.	.	.	1.015	1.026	0.599	0.000	0.001	0.019	976	.	.	.	.	GDF2	96	0	154	17	0.0994152046783626	TRUE	TRUE
ENSG00000197901.11	.	BCM	GRCh38.p13	chr11	62981315	62981315	+	T	T	C	Missense_Mutation	SNP	ENST00000377871.7	exon5	c.A866G	p.Q289R	exonic	ENSG00000197901.11	.	nonsynonymous SNV	ENSG00000197901.11:ENST00000377871.7:exon5:c.A866G:p.Q289R	11q12.3	C3L-02701	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	N	T	N	0.288	T	T	T	0.142	0.593	0.598	0.620	T	T	T	T	D	T	2.072	19.800	0.804	D	N	-0.396	1.392	-0.155	1.897	1.000	0.428	0.547	0.547	0.613	.	4.900	4.900	3.212	1.138	0.609	0.940	1.000	0.944	804	Major_facilitator_superfamily_domain	.	.	.	SLC22A6	323	0	508	64	0.111888111888112	TRUE	TRUE
ENSG00000170967.5	.	BCM	GRCh38.p13	chr11	104037099	104037099	+	C	C	T	Missense_Mutation	SNP	ENST00000302259.5	exon1	c.C277T	p.R93C	exonic	ENSG00000170967.5	.	nonsynonymous SNV	ENSG00000170967.5:ENST00000302259.5:exon1:c.C277T:p.R93C	11q22.3	C3L-02701	8.261e-06	0	0	0	0	1.504e-05	0	0	rs778186886	7.19	D	D	D	P	N	N	M	T	D	0.296	T	T	D	0.099	0.295	0.626	1.186	T	T	T	T	D	T	2.398	22.100	0.996	N	.	-0.424	1.332	-0.633	0.998	0.001	0.487	0.574	0.578	0.564	.	4.590	1.600	0.416	-0.273	-0.218	0.000	0.000	0.000	913	.	.	.	ID=COSV56386828;OCCURENCE=2(large_intestine)	DDI1	358	0	479	57	0.10634328358209	TRUE	TRUE
ENSG00000110367.13	.	BCM	GRCh38.p13	chr11	118756277	118756277	+	C	C	T	Missense_Mutation	SNP	ENST00000534980.7	exon11	c.G1157A	p.R386H	exonic	ENSG00000110367.13	.	nonsynonymous SNV	ENSG00000110367.13:ENST00000534980.7:exon11:c.G1157A:p.R386H	11q23.3	C3L-02701	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.614	D	D	D	0.640	0.728	0.851	.	D	D	D	D	D	D	4.603	32	0.999	D	D	0.848	9.802	0.869	12.468	1.000	0.719	0.723	0.702	0.714	.	6.060	6.060	7.687	1.009	0.596	1.000	1.000	0.998	516	Helicase,_C-terminal	.	.	.	DDX6	220	0	390	25	0.0602409638554217	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02701	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	306	0	460	55	0.106796116504854	TRUE	TRUE
ENSG00000135503.13	.	BCM	GRCh38.p13	chr12	51984026	51984026	+	T	T	C	Missense_Mutation	SNP	ENST00000257963.9	exon5	c.T839C	p.L280P	exonic	ENSG00000135503.13	.	nonsynonymous SNV	ENSG00000135503.13:ENST00000257963.9:exon5:c.T839C:p.L280P	12q13.13	C3L-02701	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.972	D	D	D	0.892	0.800	0.956	2.666	D	D	D	D	D	D	4.302	29.600	0.999	D	D	1.048	15.505	0.925	14.854	1.000	0.707	0.457	0.725	0.714	.	5.260	5.260	8.014	1.138	0.663	1.000	1.000	0.986	649	Protein_kinase_domain	.	.	.	ACVR1B	180	0	329	38	0.103542234332425	TRUE	TRUE
ENSG00000177169.10	.	BCM	GRCh38.p13	chr12	131910769	131910769	+	G	G	A	Missense_Mutation	SNP	ENST00000321867.6	exon12	c.G917A	p.S306N	exonic	ENSG00000177169.10	.	nonsynonymous SNV	ENSG00000177169.10:ENST00000321867.6:exon12:c.G917A:p.S306N	12q24.33	C3L-02701	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	N	0.454	T	T	D	0.142	0.301	0.310	0.171	T	T	T	T	D	D	3.485	24.700	0.996	D	D	0.598	5.902	0.527	5.411	1.000	0.707	0.644	0.723	0.714	.	4.320	4.320	2.800	1.176	0.618	0.153	1.000	0.996	976	.	.	.	.	ULK1	371	0	670	46	0.0642458100558659	TRUE	TRUE
ENSG00000183495.14	.	BCM	GRCh38.p13	chr12	131961130	131961130	+	G	G	A	Missense_Mutation	SNP	ENST00000389561.7	exon2	c.G511A	p.V171M	exonic	ENSG00000183495.14	.	nonsynonymous SNV	ENSG00000183495.14:ENST00000389561.7:exon2:c.G511A:p.V171M	12q24.33	C3L-02701	0.0341	0.0069	0.0213	0	0.0338	0.0543	0.0341	0.0014	rs61745448	13.18	D	D	D	P	D	D	M	D	N	0.854	D	D	.	0.633	.	.	1.342	D	.	T	D	T	T	3.522	24.800	0.754	D	D	0.590	5.825	0.529	5.432	1.000	0.732	0.744	0.744	0.684	.	5.790	4.900	9.473	1.176	0.676	1.000	0.626	0.083	976	E1A-binding_protein_p400,_N-terminal	0.000	Testis;Cells_Cultured_fibroblasts	ID=COSV57774473;OCCURENCE=1(stomach)	EP400	996	0	1535	121	0.0730676328502416	NA	TRUE
ENSG00000181619.11	.	BCM	GRCh38.p13	chr14	59464219	59464219	+	C	C	A	Missense_Mutation	SNP	ENST00000395116.1	exon1	c.G1008T	p.M336I	exonic	ENSG00000181619.11	.	nonsynonymous SNV	ENSG00000181619.11:ENST00000395116.1:exon1:c.G1008T:p.M336I	14q23.1	C3L-02701	.	.	.	.	.	.	.	.	.	7.20	T	D	D	P	U	D	L	T	N	0.595	T	T	D	0.150	0.474	0.443	.	T	T	T	T	D	T	3.550	24.900	0.995	D	D	0.240	3.486	0.291	3.665	1.000	0.443	0.552	0.666	0.568	.	4.310	4.310	3.958	1.026	0.597	1.000	0.998	0.998	783	GPCR,_rhodopsin-like,_7TM	.	.	.	GPR135	344	0	496	45	0.0831792975970425	TRUE	TRUE
ENSG00000066735.14	.	BCM	GRCh38.p13	chr14	104175154	104175154	+	C	C	T	Missense_Mutation	SNP	ENST00000423312.6	exon12	c.C2366T	p.T789M	exonic	ENSG00000066735.14	.	nonsynonymous SNV	ENSG00000066735.14:ENST00000423312.6:exon12:c.C2366T:p.T789M	14q32.33	C3L-02701	6.04e-05	0	0	0	0	0.0001	0	0	rs765014920	18.19	D	D	D	D	.	D	M	D	D	0.550	D	D	D	0.641	0.258	0.898	0.462	D	T	D	D	D	D	3.930	26.500	0.999	D	D	0.655	6.537	0.564	5.799	1.000	0.696	0.588	0.723	0.605	.	3.890	3.890	7.673	0.943	0.596	1.000	0.998	0.987	557	.	.	.	ID=COSV59466324;OCCURENCE=1(oesophagus),1(large_intestine)	KIF26A	315	0	518	53	0.0928196147110333	TRUE	TRUE
ENSG00000103510.20	.	BCM	GRCh38.p13	chr16	31130816	31130816	+	A	A	G	Missense_Mutation	SNP	ENST00000219797.9	exon10	c.A1228G	p.K410E	exonic	ENSG00000103510.20	.	nonsynonymous SNV	ENSG00000103510.20:ENST00000219797.9:exon10:c.A1228G:p.K410E	16p11.2	C3L-02701	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	H	.	D	0.743	D	D	D	0.872	0.534	0.608	2.308	D	T	D	D	D	D	4.313	29.700	0.999	D	D	0.912	11.355	0.799	10.087	1.000	0.731	0.744	0.750	0.714	.	5.030	5.030	9.114	1.312	0.756	1.000	1.000	0.998	57	Histone_acetyltransferase_domain,_MYST-type	.	.	.	KAT8	271	0	469	51	0.0980769230769231	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674205	7674205	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000269305.8	exon7	c.757dupA	p.T253Nfs*11	exonic	ENSG00000141510.17	.	frameshift insertion	ENSG00000141510.17:ENST00000269305.8:exon7:c.757dupA:p.T253Nfs*11	17p13.1	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	NA	NA	NA	NA	NA	NA	NA
ENSG00000197046.12	.	BCM	GRCh38.p13	chr18	45842156	45842156	+	G	G	A	Missense_Mutation	SNP	ENST00000389474.8	exon6	c.G956A	p.R319Q	exonic	ENSG00000197046.12	.	nonsynonymous SNV	ENSG00000197046.12:ENST00000389474.8:exon6:c.G956A:p.R319Q	18q12.3	C3L-02701	3.295e-05	0	0	0	0	2.997e-05	0	0.0001	rs775151990	0.20	T	T	B	B	N	N	N	T	N	0.289	T	T	T	0.014	0.153	0.389	0.551	T	T	T	T	T	T	-0.580	0.081	0.790	N	N	-1.547	0.068	-1.622	0.069	1.000	0.554	0.547	0.602	0.613	.	4.910	-5.640	-1.206	-1.807	-0.692	0.000	0.000	0.002	977	.	.	.	ID=COSV101248703;OCCURENCE=2(central_nervous_system),1(endometrium)	SIGLEC15	288	0	512	44	0.079136690647482	TRUE	NA
ENSG00000125755.19	.	BCM	GRCh38.p13	chr19	45816553	45816553	+	T	T	C	Missense_Mutation	SNP	ENST00000245934.12	exon25	c.A3283G	p.M1095V	exonic	ENSG00000125755.19	.	nonsynonymous SNV	ENSG00000125755.19:ENST00000245934.12:exon25:c.A3283G:p.M1095V	19q13.32	C3L-02701	.	.	.	.	.	.	.	.	.	8.19	D	T	B	B	D	D	L	.	N	0.621	T	T	T	0.200	0.342	0.462	0.047	T	T	D	D	D	T	2.509	22.400	0.988	D	D	-0.055	2.320	0.097	2.721	1.000	0.713	0.644	0.522	0.692	.	4.400	4.400	4.993	1.138	0.665	1.000	1.000	0.999	819	.	.	.	.	SYMPK	281	0	443	50	0.101419878296146	TRUE	TRUE
ENSG00000196263.8	.	BCM	GRCh38.p13	chr19	56524333	56524333	+	C	C	G	Missense_Mutation	SNP	ENST00000308031.10	exon5	c.C266G	p.S89C	exonic	ENSG00000196263.8	.	nonsynonymous SNV	ENSG00000196263.8:ENST00000308031.10:exon5:c.C266G:p.S89C	19q13.43	C3L-02701	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	.	D	M	T	N	0.237	T	T	T	0.054	0.465	0.472	0.666	T	T	T	T	T	T	1.562	16.130	0.673	N	N	-0.747	0.735	-0.794	0.767	0.000	0.554	0.574	0.602	0.621	.	3.340	1.030	0.109	1.026	0.599	0.000	0.997	0.996	988	.	.	.	.	ZNF471	52	0	103	10	0.0884955752212389	TRUE	TRUE
ENSG00000127903.14	.	BCM	GRCh38.p13	chr19	56663887	56663887	+	G	G	A	Missense_Mutation	SNP	ENST00000537055.4	exon2	c.C1312T	p.R438C	exonic	ENSG00000127903.14	.	nonsynonymous SNV	ENSG00000127903.14:ENST00000537055.4:exon2:c.C1312T:p.R438C	19q13.43	C3L-02701	.	.	.	.	.	.	.	.	.	5.17	D	D	.	.	.	N	M	T	D	0.372	T	T	T	0.062	.	0.273	.	T	T	T	T	D	T	2.352	21.900	0.997	N	N	-0.124	2.101	-0.474	1.244	0.000	0.487	0.574	0.578	0.613	.	2.150	1.040	-1.547	0.929	0.590	0.000	0.144	0.055	988	Zinc_finger_C2H2-type	.	.	.	ZNF835	511	0	766	76	0.0902612826603325	TRUE	TRUE
ENSG00000156282.5	.	BCM	GRCh38.p13	chr21	30166593	30166593	+	C	C	A	Missense_Mutation	SNP	ENST00000286808.5	exon1	c.G25T	p.A9S	exonic	ENSG00000156282.5	.	nonsynonymous SNV	ENSG00000156282.5:ENST00000286808.5:exon1:c.G25T:p.A9S	21q21.3	C3L-02701	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	N	L	D	N	0.067	T	D	D	0.211	0.614	0.781	0.054	T	T	T	T	D	T	2.224	21.000	0.987	D	N	-0.288	1.643	-0.246	1.679	0.714	0.487	0.574	0.574	0.564	.	5.040	3.240	0.216	1.025	0.599	0.000	0.999	0.998	561	.	.	.	.	CLDN17	114	0	191	17	0.0817307692307692	TRUE	TRUE
ENSG00000171587.15	.	BCM	GRCh38.p13	chr21	40178990	40178990	+	C	C	T	Missense_Mutation	SNP	ENST00000400454.6	exon15	c.G2884A	p.A962T	exonic	ENSG00000171587.15	.	nonsynonymous SNV	ENSG00000171587.15:ENST00000400454.6:exon15:c.G2884A:p.A962T	21q22.2	C3L-02701	.	.	.	.	.	.	.	.	rs917866485	17.20	D	D	D	D	D	D	M	T	D	0.831	D	D	D	0.656	0.877	0.879	0.525	T	T	D	D	D	D	3.907	26.400	0.999	D	D	0.684	6.903	0.596	6.171	1.000	0.487	0.574	0.547	0.564	.	4.200	4.200	3.187	1.026	0.599	1.000	1.000	1.000	882	Fibronectin_type_III	.	.	ID=COSV68022517;OCCURENCE=2(large_intestine)	DSCAM	567	1	907	71	0.0725971370143149	TRUE	TRUE
ENSG00000101974.14	.	BCM	GRCh38.p13	chrX	139798741	139798741	+	G	G	T	Missense_Mutation	SNP	ENST00000327569.7	exon9	c.C722A	p.S241Y	exonic	ENSG00000101974.14	.	nonsynonymous SNV	ENSG00000101974.14:ENST00000327569.7:exon9:c.C722A:p.S241Y	Xq27.1	C3L-02701	.	.	.	.	.	.	.	.	.	16.19	T	D	D	D	D	D	M	D	N	0.585	D	D	D	0.876	0.515	0.922	1.510	T	D	D	D	D	D	4.111	27.800	0.992	D	.	.	.	.	.	1.000	.	.	.	.	.	5.770	5.770	7.649	1.176	0.676	1.000	1.000	0.997	962	.	.	.	.	ATP11C	66	0	95	15	0.136363636363636	TRUE	TRUE
ENSG00000033050.9	.	BCM	GRCh38.p13	chr7	151224989	151224989	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000033050.9;ENSG00000285292.1	ENST00000287844.7:exon3:c.155-1G>T;ENST00000222388.6:exon3:c.155-1G>T	.	.	7q36.1	C3L-02701	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.256	33	0.993	D	.	1.070	16.304	0.891	13.373	1.000	0.359	0.340	0.232	0.221	0.983	5.810	5.810	7.058	1.026	0.599	1.000	0.841	0.414	912	.	.	.	.	ABCF2	609	0	916	93	0.0921704658077304	TRUE	TRUE
ENSG00000122952.17	.	BCM	GRCh38.p13	chr10	56358461	56358461	+	T	T	-	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000122952.17	ENST00000373944.8:exon8:c.793-2A>-	.	.	10q21.1	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZWINT	184	0	258	23	0.0818505338078292	TRUE	TRUE
ENSG00000214285.3	.	BCM	GRCh38.p13	chr10	127549488	127549488	+	G	G	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000214285.3	ENST00000398023.3:exon2:c.9-1G>T	.	.	10q26.2	C3L-02701	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.271	29.300	0.990	D	.	1.036	15.083	0.849	11.752	0.990	0.061	0.063	0.063	0.057	0.979	5.720	5.720	6.295	1.176	0.676	1.000	0.085	0.036	615	.	.	.	.	NPS	140	0	228	31	0.11969111969112	TRUE	TRUE
ENSG00000081479.15	.	BCM	GRCh38.p13	chr2	169137407	169137407	+	C	C	A	Silent	SNP	ENST00000649046.1	exon76	c.G13605T	p.V4535V	exonic	ENSG00000081479.15	.	synonymous SNV	ENSG00000081479.15:ENST00000649046.1:exon76:c.G13605T:p.V4535V	2q31.1	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRP2	455	1	642	136	0.174807197943445	TRUE	TRUE
ENSG00000163596.16	.	BCM	GRCh38.p13	chr2	202828878	202828878	+	C	C	T	Silent	SNP	ENST00000617388.4	exon2	c.G132A	p.A44A	exonic	ENSG00000163596.16	.	synonymous SNV	ENSG00000163596.16:ENST00000617388.4:exon2:c.G132A:p.A44A	2q33.2	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64173336;OCCURENCE=1(large_intestine),1(stomach)	ICA1L	226	1	424	28	0.0619469026548673	TRUE	TRUE
ENSG00000178950.17	.	BCM	GRCh38.p13	chr4	870865	870865	+	C	C	T	Silent	SNP	ENST00000314167.9	exon19	c.G2094A	p.P698P	exonic	ENSG00000178950.17	.	synonymous SNV	ENSG00000178950.17:ENST00000314167.9:exon19:c.G2094A:p.P698P	4p16.3	C3L-02701	0.0002	0.0023	8.642e-05	0.0002	0	1.5e-05	0	0	rs146114266	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100033452;OCCURENCE=1(stomach)	GAK	193	0	336	35	0.0943396226415094	TRUE	NA
ENSG00000152822.14	.	BCM	GRCh38.p13	chr6	146304665	146304665	+	C	C	T	Silent	SNP	ENST00000282753.6	exon3	c.C1005T	p.N335N	exonic	ENSG00000152822.14	.	synonymous SNV	ENSG00000152822.14:ENST00000282753.6:exon3:c.C1005T:p.N335N	6q24.3	C3L-02701	1.658e-05	0	0	0	0	3.011e-05	0	0	rs770979982	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51186172;OCCURENCE=1(pancreas)	GRM1	409	1	684	58	0.078167115902965	TRUE	TRUE
ENSG00000248767.2	.	BCM	GRCh38.p13	chr7	291182	291182	+	C	C	T	Silent	SNP	ENST00000506382.2	exon3	c.C396T	p.R132R	exonic	ENSG00000248767.2	.	synonymous SNV	ENSG00000248767.2:ENST00000506382.2:exon3:c.C396T:p.R132R	7p22.3	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV72563085;OCCURENCE=1(pancreas)	FOXL3	90	0	114	17	0.129770992366412	TRUE	NA
ENSG00000225968.7	.	BCM	GRCh38.p13	chr7	1746591	1746591	+	C	C	T	Silent	SNP	ENST00000424383.4	exon3	c.C1995T	p.A665A	exonic	ENSG00000225968.7	.	synonymous SNV	ENSG00000225968.7:ENST00000424383.4:exon3:c.C1995T:p.A665A	7p22.3	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ELFN1	165	0	192	22	0.102803738317757	TRUE	TRUE
ENSG00000106327.13	.	BCM	GRCh38.p13	chr7	100641106	100641106	+	G	G	A	Silent	SNP	ENST00000223051.8	exon2	c.C156T	p.C52C	exonic	ENSG00000106327.13	.	synonymous SNV	ENSG00000106327.13:ENST00000223051.8:exon2:c.C156T:p.C52C	7q22.1	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TFR2	74	0	92	7	0.0707070707070707	TRUE	NA
ENSG00000165609.13	.	BCM	GRCh38.p13	chr10	12167780	12167780	+	G	G	A	Silent	SNP	ENST00000491614.6	exon10	c.C582T	p.D194D	exonic	ENSG00000165609.13	.	synonymous SNV	ENSG00000165609.13:ENST00000491614.6:exon10:c.C582T:p.D194D	10p14	C3L-02701	8.237e-05	9.61e-05	0	0.0001	0	4.496e-05	0	0.0003	rs376827328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NUDT5	407	0	675	49	0.0676795580110497	TRUE	NA
ENSG00000062650.19	.	BCM	GRCh38.p13	chr10	86500591	86500591	+	T	T	G	Silent	SNP	ENST00000298767.10	exon3	c.A652C	p.R218R	exonic	ENSG00000062650.19	.	synonymous SNV	ENSG00000062650.19:ENST00000298767.10:exon3:c.A652C:p.R218R	10q23.2	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WAPL	229	0	353	22	0.0586666666666667	TRUE	TRUE
ENSG00000223953.6	.	BCM	GRCh38.p13	chr11	119339643	119339643	+	G	G	A	Silent	SNP	ENST00000528368.3	exon3	c.C420T	p.T140T	exonic	ENSG00000223953.6	.	synonymous SNV	ENSG00000223953.6:ENST00000528368.3:exon3:c.C420T:p.T140T	11q23.3	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60989870;OCCURENCE=1(large_intestine)	C1QTNF5	290	0	470	53	0.101338432122371	TRUE	TRUE
ENSG00000280090.2	.	BCM	GRCh38.p13	chr11	124424077	124424077	+	G	G	T	Silent	SNP	ENST00000356130.6	exon1	c.C795A	p.G265G	exonic	ENSG00000280090.2	.	synonymous SNV	ENSG00000280090.2:ENST00000356130.6:exon1:c.C795A:p.G265G	11q24.2	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR8B4	308	0	497	56	0.10126582278481	TRUE	TRUE
ENSG00000100767.17	.	BCM	GRCh38.p13	chr14	73251818	73251818	+	G	G	A	Silent	SNP	ENST00000644200.2	exon9	c.G825A	p.S275S	exonic	ENSG00000100767.17	.	synonymous SNV	ENSG00000100767.17:ENST00000644200.2:exon9:c.G825A:p.S275S	14q24.2	C3L-02701	0.0011	0.0004	9.81e-05	0	0	0.0019	0	0	rs375078700	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PAPLN	132	0	204	46	0.184	TRUE	NA
ENSG00000141526.16	.	BCM	GRCh38.p13	chr17	82236182	82236182	+	C	C	T	Silent	SNP	ENST00000581287.5	exon1	c.C174T	p.S58S	exonic	ENSG00000141526.16	.	synonymous SNV	ENSG00000141526.16:ENST00000581287.5:exon1:c.C174T:p.S58S	17q25.3	C3L-02701	5.829e-05	0.0002	8.661e-05	0	0	6.094e-05	0	0	rs368718021	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66430036;OCCURENCE=3(large_intestine)	SLC16A3	435	0	799	63	0.0730858468677494	TRUE	TRUE
ENSG00000123143.13	.	BCM	GRCh38.p13	chr19	14469945	14469945	+	C	C	T	Silent	SNP	ENST00000242783.11	exon18	c.C2250T	p.T750T	exonic	ENSG00000123143.13	.	synonymous SNV	ENSG00000123143.13:ENST00000242783.11:exon18:c.C2250T:p.T750T	19p13.12	C3L-02701	0.0001	0	0	0	0	1.5e-05	0	0.0007	rs200074602	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PKN1	172	0	292	16	0.051948051948052	TRUE	NA
ENSG00000174586.11	.	BCM	GRCh38.p13	chr19	58357117	58357117	+	C	C	T	Silent	SNP	ENST00000311044.8	exon3	c.G519A	p.A173A	exonic	ENSG00000174586.11	.	synonymous SNV	ENSG00000174586.11:ENST00000311044.8:exon3:c.G519A:p.A173A	19q13.43	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99568405;OCCURENCE=1(lung),1(endometrium)	ZNF497	571	0	837	78	0.0852459016393443	TRUE	TRUE
ENSG00000184032.3	.	BCM	GRCh38.p13	chr21	30635320	30635320	+	C	C	T	Silent	SNP	ENST00000330798.3	exon1	c.C57T	p.G19G	exonic	ENSG00000184032.3	.	synonymous SNV	ENSG00000184032.3:ENST00000330798.3:exon1:c.C57T:p.G19G	21q22.11	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58182517;OCCURENCE=3(large_intestine),1(bone),1(endometrium)	KRTAP20-2	512	0	771	78	0.0918727915194346	TRUE	TRUE
ENSG00000160185.15	.	BCM	GRCh38.p13	chr21	42447092	42447092	+	T	T	C	Silent	SNP	ENST00000319294.11	exon15	c.T1884C	p.N628N	exonic	ENSG00000160185.15	.	synonymous SNV	ENSG00000160185.15:ENST00000319294.11:exon15:c.T1884C:p.N628N	21q22.3	C3L-02701	.	.	.	.	.	.	.	.	rs376352061	0.13	T	.	.	.	.	N	.	T	N	0.115	T	T	T	0.028	.	0.110	.	.	.	T	T	T	T	0.592	7.435	0.916	N	N	-1.057	0.346	-1.091	0.385	0.895	0.554	0.588	0.547	0.613	.	4.460	-2.770	-0.327	-0.208	-0.133	0.116	0.928	0.992	994	.	.	.	.	UBASH3A	125	0	252	31	0.109540636042403	TRUE	NA
ENSG00000196431.4	.	BCM	GRCh38.p13	chr22	26628290	26628290	+	C	C	T	Silent	SNP	ENST00000354760.4	exon5	c.C303T	p.N101N	exonic	ENSG00000196431.4	.	synonymous SNV	ENSG00000196431.4:ENST00000354760.4:exon5:c.C303T:p.N101N	22q12.1	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61322740;OCCURENCE=1(skin)	CRYBA4	419	1	625	62	0.0902474526928675	TRUE	TRUE
ENSG00000159307.19	.	BCM	GRCh38.p13	chr22	43212456	43212456	+	G	G	A	Silent	SNP	ENST00000360835.9	exon17	c.C2190T	p.G730G	exonic	ENSG00000159307.19	.	synonymous SNV	ENSG00000159307.19:ENST00000360835.9:exon17:c.C2190T:p.G730G	22q13.2	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCUBE1	345	0	535	45	0.0775862068965517	TRUE	TRUE
ENSG00000089472.16	.	BCM	GRCh38.p13	chrX	66200697	66200697	+	A	A	G	Silent	SNP	ENST00000343002.6	exon11	c.A2022G	p.A674A	exonic	ENSG00000089472.16	.	synonymous SNV	ENSG00000089472.16:ENST00000343002.6:exon11:c.A2022G:p.A674A	Xq12	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HEPH	198	0	241	46	0.160278745644599	NA	TRUE
ENSG00000189420.8	.	BCM	GRCh38.p13	chrX	153421340	153421340	+	G	G	A	Silent	SNP	ENST00000338647.6	exon4	c.G963A	p.A321A	exonic	ENSG00000189420.8	.	synonymous SNV	ENSG00000189420.8:ENST00000338647.6:exon4:c.G963A:p.A321A	Xq28	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFP92	238	0	318	67	0.174025974025974	TRUE	TRUE
ENSG00000237298.10	.	BCM	GRCh38.p13	chr2	178751628	178751628	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000237298.10	.	.	.	2q31.2	C3L-02701	8.277e-06	0	8.691e-05	0	0	0	0	0	rs760734881	5.16	T	D	D	P	.	D	.	T	N	0.736	T	T	T	0.281	0.540	0.764	.	.	.	T	T	T	T	2.201	20.900	0.997	D	D	0.799	8.765	0.822	10.804	1.000	0.516	0.574	0.574	0.586	.	5.880	5.880	7.981	1.176	0.676	1.000	0.995	0.998	341	.	.	.	.	TTN-AS1	176	1	258	21	0.0752688172043011	TRUE	NA
ENSG00000141096.6	.	BCM	GRCh38.p13	chr16	67980386	67980386	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000141096.6	ENST00000268793.6:c.-6C>T	.	.	16q22.1	C3L-02701	.	.	.	.	.	.	.	.	rs960510134	2.14	D	D	.	.	.	N	.	T	N	0.079	T	T	T	0.022	0.209	0.134	1.608	T	.	T	T	T	.	1.273	14.190	0.937	N	N	-1.031	0.372	-1.290	0.216	0.996	0.696	0.588	0.692	0.584	.	3.410	-6.320	-0.188	-0.299	-0.139	0.000	0.014	0.003	10	.	.	.	.	DPEP3	218	0	357	26	0.0678851174934726	TRUE	NA
ENSG00000211642.3	.	BCM	GRCh38.p13	chr22	22215055	22215055	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000211642.3	.	.	.	22q11.22	C3L-02701	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGLV10-54	400	0	580	65	0.10077519379845	TRUE	TRUE
ENSG00000115896.16	.	BCM	GRCh38.p13	chr2	197805314	197805314	+	C	C	-	Frame_Shift_Del	DEL	ENST00000428675.6	exon1	c.215delC	p.R74Gfs*48	exonic	ENSG00000115896.16	.	frameshift deletion	ENSG00000115896.16:ENST00000428675.6:exon1:c.215delC:p.R74Gfs*48	2q33.1	C3L-00102	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLCL1	20	0	47	5	0.0961538461538462	TRUE	NA
ENSG00000012223.13	.	BCM	GRCh38.p13	chr3	46455879	46455879	+	C	C	T	Missense_Mutation	SNP	ENST00000231751.9	exon4	c.G416A	p.R139H	exonic	ENSG00000012223.13	.	nonsynonymous SNV	ENSG00000012223.13:ENST00000231751.9:exon4:c.G416A:p.R139H	3p21.31	C3L-00102	7.521e-05	0.0008	8.685e-05	0	0	0	0	0	rs142920270	2.20	D	D	B	B	N	N	L	T	N	0.217	T	T	T	0.076	.	0.188	0.086	T	T	T	T	T	T	0.539	6.909	0.952	N	N	-1.188	0.235	-1.266	0.232	0.990	0.516	0.590	0.577	0.586	.	4.890	-1.760	0.325	-1.407	-0.818	0.031	0.006	0.053	423	Transferrin-like_domain	.	.	ID=COSV51607039;OCCURENCE=1(endometrium)	LTF	119	0	277	22	0.0735785953177258	TRUE	TRUE
ENSG00000175792.12	.	BCM	GRCh38.p13	chr3	128098942	128098942	+	C	C	T	Missense_Mutation	SNP	ENST00000322623.10	exon7	c.G757A	p.G253R	exonic	ENSG00000175792.12	.	nonsynonymous SNV	ENSG00000175792.12:ENST00000322623.10:exon7:c.G757A:p.G253R	3q21.3	C3L-00102	.	.	.	.	.	.	.	.	.	14.19	D	D	B	P	D	D	M	T	D	0.934	T	T	D	0.571	0.730	0.746	1.515	D	D	D	D	D	.	3.765	25.700	0.998	D	D	0.491	4.969	0.558	5.731	1.000	0.722	0.725	0.699	0.714	.	5.750	5.750	7.416	0.980	0.549	1.000	0.360	0.886	763	AAA+_ATPase_domain;TIP49,_C-terminal	.	.	.	RUVBL1	239	0	426	31	0.0678336980306346	TRUE	TRUE
ENSG00000138759.19	.	BCM	GRCh38.p13	chr4	78481876	78481876	+	G	G	A	Missense_Mutation	SNP	ENST00000512123.4	exon57	c.G8516A	p.R2839Q	exonic	ENSG00000138759.19	.	nonsynonymous SNV	ENSG00000138759.19:ENST00000512123.4:exon57:c.G8516A:p.R2839Q	4q21.21	C3L-00102	8.281e-06	0	8.639e-05	0	0	0	0	0	rs752028327	8.13	.	D	.	.	D	D	.	.	.	0.849	T	T	T	0.298	.	0.776	.	T	.	T	D	D	D	4.801	33	0.999	D	D	0.765	8.141	0.763	9.114	1.000	0.707	0.590	0.725	0.568	.	5.570	5.570	9.856	1.146	0.676	1.000	0.945	0.397	901	.	.	.	ID=COSV53587372;OCCURENCE=1(oesophagus)	FRAS1	336	0	710	58	0.0755208333333333	TRUE	TRUE
ENSG00000197826.11	.	BCM	GRCh38.p13	chr4	80963518	80963518	+	C	C	T	Missense_Mutation	SNP	ENST00000358105.7	exon6	c.C608T	p.A203V	exonic	ENSG00000197826.11	.	nonsynonymous SNV	ENSG00000197826.11:ENST00000358105.7:exon6:c.C608T:p.A203V	4q21.21	C3L-00102	1.662e-05	0	0	0	0	3.021e-05	0	0	rs200295695	0.18	T	T	B	B	N	N	.	T	N	0.118	T	T	T	0.006	0.249	0.014	0.099	.	T	T	T	T	T	-0.874	0.017	0.861	N	N	-1.306	0.161	-1.389	0.157	0.006	0.487	0.574	0.574	0.564	.	5.520	-4.180	-1.563	-3.159	-3.122	0.000	0.000	0.000	775	.	.	.	.	CFAP299	220	0	261	18	0.0645161290322581	TRUE	NA
ENSG00000039139.9	.	BCM	GRCh38.p13	chr5	13776525	13776525	+	C	C	T	Missense_Mutation	SNP	ENST00000265104.4	exon55	c.G9287A	p.R3096Q	exonic	ENSG00000039139.9	.	nonsynonymous SNV	ENSG00000039139.9:ENST00000265104.4:exon55:c.G9287A:p.R3096Q	5p15.2	C3L-00102	.	.	.	.	.	.	.	.	.	14.19	D	.	D	P	D	D	M	T	D	0.900	T	T	D	0.544	.	0.813	0.304	T	D	D	D	D	D	4.180	28.500	1.000	D	D	0.978	13.260	0.943	15.733	1.000	0.554	0.574	0.574	0.621	.	5.970	5.970	7.813	1.026	0.599	1.000	1.000	0.998	687	Dynein_heavy_chain,_AAA_module_D4	.	.	ID=COSV54203252;OCCURENCE=1(breast),1(liver),2(large_intestine),4(skin),1(lung)	DNAH5	296	0	537	36	0.06282722513089	TRUE	TRUE
ENSG00000113595.15	.	BCM	GRCh38.p13	chr5	65614151	65614151	+	C	C	T	Missense_Mutation	SNP	ENST00000231524.14	exon3	c.G313A	p.G105R	exonic	ENSG00000113595.15	.	nonsynonymous SNV	ENSG00000113595.15:ENST00000231524.14:exon3:c.G313A:p.G105R	5q12.3	C3L-00102	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	D	D	N	T	N	0.869	T	T	D	0.617	0.501	0.744	1.231	T	T	D	D	D	D	3.368	24.300	0.999	D	D	0.622	6.156	0.655	6.988	1.000	0.651	0.709	0.659	0.684	.	5.250	5.250	7.286	1.026	0.549	1.000	0.999	0.996	866	.	.	.	.	TRIM23	222	0	410	43	0.0949227373068433	TRUE	TRUE
ENSG00000204371.11	.	BCM	GRCh38.p13	chr6	31884393	31884393	+	G	G	A	Missense_Mutation	SNP	ENST00000375537.8	exon21	c.C2770T	p.R924W	exonic	ENSG00000204371.11	.	nonsynonymous SNV	ENSG00000204371.11:ENST00000375537.8:exon21:c.C2770T:p.R924W	6p21.33	C3L-00102	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	M	D	D	0.780	D	D	D	0.656	0.623	0.972	1.047	T	D	D	D	D	.	4.076	27.600	0.999	D	D	0.129	3.002	0.073	2.628	0.528	0.707	0.702	0.725	0.714	.	5.340	2.240	1.912	1.164	0.662	1.000	1.000	0.953	912	Pre-SET_domain	.	.	.	EHMT2	43	0	162	10	0.0581395348837209	TRUE	TRUE
ENSG00000135316.18	.	BCM	GRCh38.p13	chr6	85619357	85619357	+	C	C	A	Missense_Mutation	SNP	ENST00000369622.8	exon9	c.G1069T	p.A357S	exonic	ENSG00000135316.18	.	nonsynonymous SNV	ENSG00000135316.18:ENST00000369622.8:exon9:c.G1069T:p.A357S	6q14.3	C3L-00102	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.246	T	T	T	0.080	0.735	0.277	0.823	T	T	T	T	T	T	1.611	16.440	0.504	D	N	-0.313	1.581	-0.143	1.929	1.000	0.672	0.702	0.702	0.711	.	5.190	4.300	1.492	0.074	0.597	0.918	0.998	1.000	720	RNA_recognition_motif_domain	.	.	.	SYNCRIP	262	0	324	20	0.0581395348837209	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971165	21971170	+	AGCAGC	AGCAGC	-	In_Frame_Del	DEL	ENST00000304494.9	exon2	c.189_194del	p.L64_L65del	exonic	ENSG00000147889.17	.	nonframeshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.189_194del:p.L64_L65del	9p21.3	C3L-00102	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	293	0	690	78	0.1015625	NA	TRUE
ENSG00000172350.10	.	BCM	GRCh38.p13	chr11	119158587	119158587	+	G	G	A	Missense_Mutation	SNP	ENST00000619701.5	exon11	c.G1198A	p.V400M	exonic	ENSG00000172350.10	.	nonsynonymous SNV	ENSG00000172350.10:ENST00000619701.5:exon11:c.G1198A:p.V400M	11q23.3	C3L-00102	1.647e-05	0	8.637e-05	0	0	1.498e-05	0	0	rs759324902	5.17	.	D	D	P	N	N	M	.	.	0.552	T	T	T	0.336	.	0.638	.	T	T	T	T	T	D	3.552	24.900	0.999	D	N	0.352	4.061	0.303	3.733	0.000	0.554	0.590	0.602	0.568	.	5.630	4.710	2.094	1.176	0.676	0.984	0.773	0.616	231	ABC-2_type_transporter	.	.	ID=COSV56644177;OCCURENCE=1(biliary_tract),1(upper_aerodigestive_tract)	ABCG4	195	0	394	22	0.0528846153846154	TRUE	TRUE
ENSG00000172572.6	.	BCM	GRCh38.p13	chr12	20369450	20369450	+	C	C	T	Missense_Mutation	SNP	ENST00000359062.3	exon1	c.C166T	p.R56W	exonic	ENSG00000172572.6	.	nonsynonymous SNV	ENSG00000172572.6:ENST00000359062.3:exon1:c.C166T:p.R56W	12p12.2	C3L-00102	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.184	T	T	D	0.194	0.527	0.703	1.082	T	T	T	T	T	T	1.991	19.190	0.999	N	N	-0.481	1.214	-0.366	1.435	1.000	0.455	0.590	0.607	0.250	.	4.540	4.540	0.290	0.127	-0.181	0.247	0.997	0.453	972	.	.	.	.	PDE3A	142	0	367	27	0.0685279187817259	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3L-00102	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	325	0	438	50	0.102459016393443	TRUE	TRUE
ENSG00000137770.14	.	BCM	GRCh38.p13	chr15	44490894	44490894	+	A	A	C	Missense_Mutation	SNP	ENST00000260327.9	exon5	c.A586C	p.N196H	exonic	ENSG00000137770.14	.	nonsynonymous SNV	ENSG00000137770.14:ENST00000260327.9:exon5:c.A586C:p.N196H	15q15.3	C3L-00102	.	.	.	.	.	.	.	.	.	8.20	D	T	B	B	D	D	L	T	N	0.473	T	T	D	0.187	0.251	0.426	0.118	T	T	T	T	D	D	2.784	23.000	0.985	D	D	-0.072	2.266	0.122	2.825	1.000	0.707	0.725	0.725	0.714	.	4.900	4.900	4.645	1.307	0.751	1.000	1.000	1.000	197	.	.	.	.	CTDSPL2	278	0	362	47	0.114914425427873	TRUE	TRUE
ENSG00000166473.17	.	BCM	GRCh38.p13	chr16	81207575	81207575	+	G	G	A	Missense_Mutation	SNP	ENST00000337114.8	exon5	c.C821T	p.T274M	exonic	ENSG00000166473.17	.	nonsynonymous SNV	ENSG00000166473.17:ENST00000337114.8:exon5:c.C821T:p.T274M	16q23.2	C3L-00102	2.487e-05	0.0001	0	0	0	2.999e-05	0	0	rs372674125	2.16	.	.	B	B	N	N	.	D	N	0.164	T	T	D	0.114	.	0.230	.	T	.	T	T	T	T	0.979	11.350	0.888	N	N	-0.783	0.680	-0.869	0.662	0.000	0.487	0.590	0.574	0.542	.	5.250	-3.240	0.075	-0.108	0.676	0.015	0.808	0.662	952	.	.	.	ID=COSV104397628;OCCURENCE=1(large_intestine)	PKD1L2	143	1	259	28	0.0975609756097561	TRUE	NA
ENSG00000170832.13	.	BCM	GRCh38.p13	chr17	60183308	60183308	+	G	G	A	Missense_Mutation	SNP	ENST00000300896.9	exon31	c.C3980T	p.P1327L	exonic	ENSG00000170832.13	.	nonsynonymous SNV	ENSG00000170832.13:ENST00000300896.9:exon31:c.C3980T:p.P1327L	17q23.1	C3L-00102	8.237e-06	0	0	0	0	1.498e-05	0	0	rs761651563	3.20	T	T	B	B	N	D	N	T	N	0.186	T	T	T	0.080	0.548	0.129	0.565	T	T	T	T	T	D	2.015	19.370	0.885	D	N	-0.451	1.274	-0.220	1.739	0.000	0.707	0.654	0.698	0.714	.	5.780	4.800	2.433	1.172	0.672	1.000	1.000	0.996	482	Ubiquitin_specific_protease_domain;Peptidase_C19,_ubiquitin_carboxyl-terminal_hydrolase	.	.	.	USP32	361	1	646	80	0.110192837465565	NA	TRUE
ENSG00000179163.11	.	BCM	GRCh38.p13	chr1	23859796	23859796	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000179163.11	ENST00000374479.3:exon4:c.768+2T>C	.	.	1p36.11	C3L-00102	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.501	32	0.947	D	.	0.870	10.300	0.666	7.165	0.963	0.295	0.304	0.084	0.093	0.733	6.030	3.670	6.994	0.243	0.660	1.000	0.911	0.739	627	.	.	.	.	FUCA1	262	0	375	54	0.125874125874126	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673838	7673838	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon8:c.783-1G>T	.	.	17p13.1	C3L-00102	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.753	32	0.993	D	.	0.947	12.324	0.737	8.497	1.000	0.295	0.272	0.343	0.120	0.969	4.820	4.820	7.905	1.022	0.596	1.000	0.054	0.668	432	.	.	.	ID=COSV52668714;OCCURENCE=5(breast),2(oesophagus),3(large_intestine),1(central_nervous_system),4(ovary),2(stomach),1(pancreas),1(skin),12(lung),4(upper_aerodigestive_tract)	TP53	630	0	928	100	0.0972762645914397	TRUE	TRUE
ENSG00000176208.9	.	BCM	GRCh38.p13	chr17	30887373	30887373	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000176208.9	ENST00000321990.5:exon19:c.4258+1G>A	.	.	17q11.2	C3L-00102	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.852	33	0.994	D	.	1.089	17.045	0.936	15.371	1.000	0.322	0.319	0.084	0.110	0.982	5.680	5.680	7.042	1.140	0.612	1.000	0.350	0.717	855	.	.	.	ID=COSV104639298;OCCURENCE=1(ovary)	ATAD5	196	0	246	17	0.064638783269962	TRUE	TRUE
ENSG00000055070.17	.	BCM	GRCh38.p13	chr1	16393435	16393435	+	G	G	T	Silent	SNP	ENST00000401088.9	exon3	c.G309T	p.L103L	exonic	ENSG00000055070.17	.	synonymous SNV	ENSG00000055070.17:ENST00000401088.9:exon3:c.G309T:p.L103L	1p36.13	C3L-00102	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SZRD1	200	2	381	49	0.113953488372093	TRUE	TRUE
ENSG00000158859.10	.	BCM	GRCh38.p13	chr1	161198175	161198175	+	G	G	A	Silent	SNP	ENST00000367996.6	exon1	c.C453T	p.G151G	exonic	ENSG00000158859.10	.	synonymous SNV	ENSG00000158859.10:ENST00000367996.6:exon1:c.C453T:p.G151G	1q23.3	C3L-00102	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAMTS4	197	0	377	49	0.115023474178404	TRUE	NA
ENSG00000010327.10	.	BCM	GRCh38.p13	chr3	52517363	52517363	+	C	C	T	Silent	SNP	ENST00000321725.10	exon43	c.C4533T	p.H1511H	exonic	ENSG00000010327.10	.	synonymous SNV	ENSG00000010327.10:ENST00000321725.10:exon43:c.C4533T:p.H1511H	3p21.1	C3L-00102	6.14e-05	0	0	0	0	0	0	0.0006	rs572091832	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STAB1	70	0	136	10	0.0684931506849315	TRUE	NA
ENSG00000196159.12	.	BCM	GRCh38.p13	chr4	125490451	125490451	+	G	G	A	Silent	SNP	ENST00000674496.1	exon17	c.G13629A	p.P4543P	exonic	ENSG00000196159.12	.	synonymous SNV	ENSG00000196159.12:ENST00000674496.1:exon17:c.G13629A:p.P4543P	4q28.1	C3L-00102	6.591e-05	0	0.0002	0	0	5.995e-05	0	0.0001	rs757657669	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58671354;OCCURENCE=1(skin),1(prostate)	FAT4	289	0	510	60	0.105263157894737	TRUE	TRUE
ENSG00000174705.13	.	BCM	GRCh38.p13	chr5	172339431	172339431	+	G	G	A	Silent	SNP	ENST00000311601.6	exon13	c.C1674T	p.G558G	exonic	ENSG00000174705.13	.	synonymous SNV	ENSG00000174705.13:ENST00000311601.6:exon13:c.C1674T:p.G558G	5q35.1	C3L-00102	3.309e-05	0	0	0.0001	0	0	0	0.0002	rs761047260	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SH3PXD2B	145	0	358	22	0.0578947368421053	TRUE	NA
ENSG00000188162.11	.	BCM	GRCh38.p13	chr11	17611360	17611360	+	C	C	T	Silent	SNP	ENST00000399391.7	exon35	c.C6096T	p.I2032I	exonic	ENSG00000188162.11	.	synonymous SNV	ENSG00000188162.11:ENST00000399391.7:exon35:c.C6096T:p.I2032I	11p15.1	C3L-00102	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100695766;OCCURENCE=1(stomach)	OTOG	98	0	258	28	0.0979020979020979	TRUE	NA
ENSG00000196557.13	.	BCM	GRCh38.p13	chr16	1205203	1205203	+	C	C	T	Silent	SNP	ENST00000348261.11	exon11	c.C2541T	p.C847C	exonic	ENSG00000196557.13	.	synonymous SNV	ENSG00000196557.13:ENST00000348261.11:exon11:c.C2541T:p.C847C	16p13.3	C3L-00102	4.179e-05	0.0001	0	0.0001	0	4.558e-05	0	0	rs201227047	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61984094;OCCURENCE=1(stomach)	CACNA1H	116	0	222	29	0.115537848605578	TRUE	TRUE
ENSG00000116731.22	.	BCM	GRCh38.p13	chr1	13780260	13780260	+	A	A	T	Missense_Mutation	SNP	ENST00000235372.11	exon8	c.A2465T	p.Q822L	exonic	ENSG00000116731.22	.	nonsynonymous SNV	ENSG00000116731.22:ENST00000235372.11:exon8:c.A2465T:p.Q822L	1p36.21	C3N-01375	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.723	T	T	T	0.307	0.440	0.405	0.743	T	T	T	T	D	D	3.926	26.500	0.991	D	D	0.808	8.948	0.796	10.010	1.000	0.672	0.702	0.609	0.636	.	5.910	5.910	6.958	1.312	0.756	1.000	0.994	0.995	970	.	.	.	.	PRDM2	99	0	119	18	0.131386861313869	TRUE	TRUE
ENSG00000143819.12	.	BCM	GRCh38.p13	chr1	225839937	225839937	+	G	G	C	Missense_Mutation	SNP	ENST00000614058.4	exon6	c.G831C	p.R277S	exonic	ENSG00000143819.12	.	nonsynonymous SNV	ENSG00000143819.12:ENST00000614058.4:exon6:c.G831C:p.R277S	1q42.12	C3N-01375	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	N	0.306	T	T	D	0.073	0.418	0.326	0.229	T	T	T	T	T	T	0.526	6.769	0.814	N	D	-1.324	0.152	-1.362	0.171	0.172	0.707	0.694	0.644	0.714	.	5.570	-3.180	-0.445	0.218	-0.181	0.008	0.123	0.031	637	.	.	.	.	EPHX1	841	1	1052	145	0.121136173767753	TRUE	TRUE
ENSG00000115548.17	.	BCM	GRCh38.p13	chr2	86490987	86490987	+	G	G	A	Missense_Mutation	SNP	ENST00000312912.10	exon24	c.G3680A	p.G1227E	exonic	ENSG00000115548.17	.	nonsynonymous SNV	ENSG00000115548.17:ENST00000312912.10:exon24:c.G3680A:p.G1227E	2p11.2	C3N-01375	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.951	D	D	D	0.687	0.806	0.809	2.224	D	D	D	D	D	D	4.229	28.900	0.998	D	D	0.844	9.699	0.819	10.705	1.000	0.707	0.725	0.725	0.714	.	4.890	4.890	10.003	1.176	0.676	1.000	1.000	1.000	500	JmjC_domain	.	.	.	KDM3A	173	0	308	18	0.0552147239263804	TRUE	TRUE
ENSG00000154783.12	.	BCM	GRCh38.p13	chr3	14821314	14821314	+	G	G	A	Missense_Mutation	SNP	ENST00000285046.10	exon1	c.G2243A	p.R748H	exonic	ENSG00000154783.12	.	nonsynonymous SNV	ENSG00000154783.12:ENST00000285046.10:exon1:c.G2243A:p.R748H	3p25.1	C3N-01375	2.487e-05	0	0	0	0	3e-05	0	6.056e-05	rs761640697	15.20	D	D	D	D	D	D	M	T	D	0.530	D	D	D	0.434	0.244	0.807	0.742	T	T	T	T	D	D	3.772	25.700	1.000	D	D	0.839	9.587	0.806	10.314	1.000	0.722	0.590	0.710	0.735	.	5.030	5.030	9.246	1.121	0.618	1.000	0.985	0.934	923	.	.	.	ID=COSV53238120;OCCURENCE=2(large_intestine),1(haematopoietic_and_lymphoid_tissue)	FGD5	213	0	269	34	0.112211221122112	TRUE	TRUE
ENSG00000163071.11	.	BCM	GRCh38.p13	chr4	52072014	52072014	+	C	C	T	Missense_Mutation	SNP	ENST00000295213.9	exon6	c.C616T	p.R206W	exonic	ENSG00000163071.11	.	nonsynonymous SNV	ENSG00000163071.11:ENST00000295213.9:exon6:c.C616T:p.R206W	4q12	C3N-01375	.	.	.	.	.	.	.	.	rs752171868	7.20	D	D	D	B	N	N	M	D	D	0.140	T	D	T	0.241	0.203	0.231	0.161	T	T	T	T	T	T	1.006	11.700	0.951	N	N	-0.754	0.724	-0.972	0.524	0.001	0.615	0.588	0.659	0.595	.	4.170	-2.300	-0.060	-2.805	-1.229	0.000	0.000	0.000	.	.	.	.	ID=COSV104401127;OCCURENCE=1(large_intestine)	SPATA18	428	0	613	65	0.0958702064896755	TRUE	NA
ENSG00000164161.10	.	BCM	GRCh38.p13	chr4	144646763	144646763	+	G	G	A	Missense_Mutation	SNP	ENST00000296575.8	exon1	c.G88A	p.E30K	exonic	ENSG00000164161.10	.	nonsynonymous SNV	ENSG00000164161.10:ENST00000296575.8:exon1:c.G88A:p.E30K	4q31.21	C3N-01375	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	L	T	N	0.340	T	T	D	0.194	0.187	0.375	0.835	T	T	T	T	D	D	4.437	31	0.999	D	D	0.628	6.218	0.653	6.949	1.000	0.564	0.492	0.504	0.562	.	5.220	5.220	7.230	1.176	0.618	1.000	0.984	0.964	877	.	.	.	ID=COSV56839107;OCCURENCE=2(skin)	HHIP	261	0	383	41	0.0966981132075472	TRUE	TRUE
ENSG00000164588.8	.	BCM	GRCh38.p13	chr5	45262108	45262108	+	G	G	A	Missense_Mutation	SNP	ENST00000303230.6	exon8	c.C2486T	p.A829V	exonic	ENSG00000164588.8	.	nonsynonymous SNV	ENSG00000164588.8:ENST00000303230.6:exon8:c.C2486T:p.A829V	5p12	C3N-01375	.	.	.	.	.	.	.	.	.	10.20	D	D	B	B	N	N	L	D	N	0.016	D	D	D	0.264	0.266	0.590	0.382	T	T	D	T	D	T	2.436	22.200	0.996	D	D	-0.219	1.823	-0.125	1.978	0.956	0.615	0.574	0.659	0.564	.	4.880	4.880	4.399	1.176	0.676	0.976	0.969	0.925	427	.	.	.	.	HCN1	127	0	233	31	0.117424242424242	TRUE	TRUE
ENSG00000112893.9	.	BCM	GRCh38.p13	chr5	109774846	109774848	+	CTC	CTC	-	In_Frame_Del	DEL	ENST00000261483.4	exon8	c.1255_1257del	p.L420del	exonic	ENSG00000112893.9	.	nonframeshift deletion	ENSG00000112893.9:ENST00000261483.4:exon8:c.1255_1257del:p.L420del	5q21.3	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAN2A1	348	1	486	52	0.0966542750929368	TRUE	TRUE
ENSG00000069018.19	.	BCM	GRCh38.p13	chr5	136247501	136247501	+	C	C	T	Missense_Mutation	SNP	ENST00000513104.6	exon7	c.G1814A	p.R605Q	exonic	ENSG00000069018.19	.	nonsynonymous SNV	ENSG00000069018.19:ENST00000513104.6:exon7:c.G1814A:p.R605Q	5q31.1	C3N-01375	5.018e-05	0.0001	0	0	0	7.529e-05	0	0	rs760900591	11.19	T	.	B	B	D	D	L	D	N	0.442	D	D	D	0.531	.	0.858	0.936	T	D	T	D	T	D	2.492	22.400	0.999	D	D	0.117	2.956	0.268	3.537	0.653	0.497	0.590	0.547	0.530	.	5.440	4.510	5.553	1.026	0.549	1.000	0.999	0.996	692	Ion_transport_domain	.	.	ID=COSV61461327;OCCURENCE=2(skin)	TRPC7	113	0	150	12	0.0740740740740741	TRUE	TRUE
ENSG00000137266.14	.	BCM	GRCh38.p13	chr6	3273377	3273377	+	C	C	T	Missense_Mutation	SNP	ENST00000406686.7	exon10	c.G1739A	p.G580D	exonic	ENSG00000137266.14	.	nonsynonymous SNV	ENSG00000137266.14:ENST00000406686.7:exon10:c.G1739A:p.G580D	6p25.2	C3N-01375	.	.	.	.	.	.	.	.	.	15.20	T	D	D	D	D	D	M	T	D	0.932	T	T	D	0.609	0.602	0.806	1.192	D	T	D	D	D	D	3.876	26.200	0.999	D	D	0.580	5.723	0.612	6.382	1.000	0.650	0.520	0.607	0.509	.	5.410	5.410	7.436	1.026	0.599	1.000	0.942	0.983	851	Major_facilitator_superfamily_domain	.	.	ID=COSV100978465;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	SLC22A23	248	0	495	53	0.0967153284671533	TRUE	TRUE
ENSG00000137411.18	.	BCM	GRCh38.p13	chr6	30918835	30918835	+	G	G	T	Missense_Mutation	SNP	ENST00000321897.9	exon10	c.G994T	p.V332F	exonic	ENSG00000137411.18	.	nonsynonymous SNV	ENSG00000137411.18:ENST00000321897.9:exon10:c.G994T:p.V332F	6p21.33	C3N-01375	.	.	.	.	.	.	.	.	.	9.20	D	D	P	B	N	D	M	T	D	0.796	T	T	D	0.201	0.593	0.450	1.295	T	T	T	T	D	D	3.390	24.400	0.996	D	N	0.046	2.679	-0.015	2.309	0.948	0.707	0.725	0.725	0.714	.	4.540	1.200	0.984	0.180	0.676	1.000	0.988	0.982	917	Aminoacyl-tRNA_synthetase,_class_Ia	.	.	.	VARS2	188	0	323	47	0.127027027027027	TRUE	TRUE
ENSG00000002933.9	.	BCM	GRCh38.p13	chr7	150804836	150804836	+	C	C	T	Nonsense_Mutation	SNP	ENST00000004103.8	exon7	c.C676T	p.Q226X	exonic	ENSG00000002933.9	.	stopgain	ENSG00000002933.9:ENST00000004103.8:exon7:c.C676T:p.Q226X	7q36.1	C3N-01375	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	D	.	.	.	0.102	.	.	.	.	.	.	.	.	.	D	D	.	.	4.987	33	0.876	N	N	-0.364	1.463	-0.758	0.817	0.609	0.516	0.590	0.577	0.530	.	3.880	-2.180	-1.476	-2.352	-0.839	0.000	0.003	0.019	769	.	.	.	.	TMEM176A	189	1	311	29	0.0852941176470588	TRUE	TRUE
ENSG00000186350.12	.	BCM	GRCh38.p13	chr9	134421695	134421695	+	A	A	C	Missense_Mutation	SNP	ENST00000481739.2	exon6	c.A800C	p.N267T	exonic	ENSG00000186350.12	.	nonsynonymous SNV	ENSG00000186350.12:ENST00000481739.2:exon6:c.A800C:p.N267T	9q34.2	C3N-01375	.	.	.	.	.	.	.	.	.	16.20	D	D	P	B	D	D	L	D	D	0.749	D	D	D	0.689	0.411	0.900	1.667	T	D	D	D	D	D	3.086	23.600	0.993	D	D	0.157	3.118	0.253	3.455	1.000	0.672	0.702	0.723	0.711	.	4.510	4.510	8.891	1.309	0.689	1.000	0.999	0.840	784	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	RXRA	30	0	59	9	0.132352941176471	TRUE	TRUE
ENSG00000176978.14	.	BCM	GRCh38.p13	chr9	137110920	137110920	+	C	C	T	Missense_Mutation	SNP	ENST00000371579.7	exon12	c.G1303A	p.A435T	exonic	ENSG00000176978.14	.	nonsynonymous SNV	ENSG00000176978.14:ENST00000371579.7:exon12:c.G1303A:p.A435T	9q34.3	C3N-01375	8.697e-06	0	0	0.0001	0	0	0	0	rs770245778	11.20	D	T	D	P	D	N	M	D	D	0.571	D	D	D	0.472	0.713	0.909	0.299	T	T	T	T	D	T	2.906	23.200	0.997	D	N	0.179	3.213	0.037	2.490	1.000	0.707	0.698	0.723	0.714	.	4.720	3.710	0.918	0.958	0.520	0.474	0.003	0.008	988	.	.	.	.	DPP7	265	0	394	35	0.0815850815850816	TRUE	NA
ENSG00000107897.19	.	BCM	GRCh38.p13	chr10	27218096	27218096	+	T	T	C	Missense_Mutation	SNP	ENST00000375888.5	exon7	c.A740G	p.D247G	exonic	ENSG00000107897.19	.	nonsynonymous SNV	ENSG00000107897.19:ENST00000375888.5:exon7:c.A740G:p.D247G	10p12.1	C3N-01375	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	L	D	N	0.211	T	T	D	0.076	0.402	0.633	0.147	T	T	T	T	T	T	2.382	22.000	0.759	D	N	-0.668	0.867	-0.536	1.145	0.014	0.706	0.725	0.710	0.714	.	4.680	2.380	2.315	1.138	0.603	0.983	1.000	0.978	744	.	.	.	.	ACBD5	233	1	676	65	0.087719298245614	TRUE	TRUE
ENSG00000165323.15	.	BCM	GRCh38.p13	chr11	92800406	92800406	+	T	T	C	Missense_Mutation	SNP	ENST00000409404.6	exon9	c.T7393C	p.Y2465H	exonic	ENSG00000165323.15	.	nonsynonymous SNV	ENSG00000165323.15:ENST00000409404.6:exon9:c.T7393C:p.Y2465H	11q14.3	C3N-01375	.	.	.	.	.	.	.	.	.	5.15	D	.	.	.	.	N	M	T	D	0.525	T	T	T	0.352	0.728	0.303	.	T	T	T	T	D	.	3.741	25.600	0.998	D	N	0.167	3.160	0.264	3.512	0.275	0.615	0.574	0.659	0.621	.	5.950	4.830	4.067	1.138	0.665	1.000	0.999	0.987	906	Cadherin-like	.	.	.	FAT3	301	0	362	30	0.076530612244898	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-01375	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	289	0	471	55	0.104562737642586	TRUE	TRUE
ENSG00000170486.11	.	BCM	GRCh38.p13	chr12	52591598	52591598	+	C	C	T	Missense_Mutation	SNP	ENST00000293745.7	exon5	c.G829A	p.D277N	exonic	ENSG00000170486.11	.	nonsynonymous SNV	ENSG00000170486.11:ENST00000293745.7:exon5:c.G829A:p.D277N	12q13.13	C3N-01375	0.0001	0	0.0008	0.0001	0.0002	4.508e-05	0	0	rs548680308	11.20	D	T	P	B	D	D	M	D	D	0.373	D	D	D	0.393	0.593	0.760	0.316	T	T	T	T	D	T	2.846	23.100	0.999	D	N	0.384	4.244	0.349	4.016	0.754	0.497	0.590	0.547	0.542	.	4.220	4.220	4.830	0.074	0.596	1.000	0.020	0.457	835	Intermediate_filament,_rod_domain	.	.	ID=COSV53374596;OCCURENCE=3(oesophagus)	KRT72	89	0	109	37	0.253424657534247	TRUE	TRUE
ENSG00000068650.18	.	BCM	GRCh38.p13	chr13	112826845	112826845	+	A	A	G	Missense_Mutation	SNP	ENST00000487903.5	exon12	c.A1175G	p.E392G	exonic	ENSG00000068650.18	.	nonsynonymous SNV	ENSG00000068650.18:ENST00000487903.5:exon12:c.A1175G:p.E392G	13q34	C3N-01375	.	.	.	.	.	.	.	.	.	13.20	D	D	B	B	D	D	M	T	D	0.673	T	T	D	0.447	0.481	0.524	0.415	T	T	D	D	D	D	3.595	25.000	0.997	D	D	0.203	3.317	0.186	3.118	1.000	0.707	0.725	0.725	0.714	.	5.400	5.400	8.838	1.278	0.756	1.000	0.598	0.815	994	.	.	.	.	ATP11A	347	0	642	62	0.0880681818181818	TRUE	TRUE
ENSG00000197324.9	.	BCM	GRCh38.p13	chr14	22875604	22875604	+	C	C	T	Missense_Mutation	SNP	ENST00000359591.9	exon5	c.C656T	p.S219F	exonic	ENSG00000197324.9	.	nonsynonymous SNV	ENSG00000197324.9:ENST00000359591.9:exon5:c.C656T:p.S219F	14q11.2	C3N-01375	.	.	.	.	.	.	.	.	.	2.20	D	D	B	B	N	N	L	T	N	0.256	T	T	T	0.072	0.537	0.275	0.269	T	T	T	T	T	T	1.449	15.410	0.997	N	N	-0.584	1.017	-0.456	1.275	1.000	0.706	0.698	0.710	0.714	.	5.730	3.910	0.543	0.129	-0.182	0.032	0.998	0.980	801	CUB_domain	.	.	.	LRP10	149	0	293	61	0.172316384180791	TRUE	TRUE
ENSG00000137812.20	.	BCM	GRCh38.p13	chr15	40622053	40622053	+	A	A	T	Missense_Mutation	SNP	ENST00000346991.9	exon11	c.A1867T	p.S623C	exonic	ENSG00000137812.20	.	nonsynonymous SNV	ENSG00000137812.20:ENST00000346991.9:exon11:c.A1867T:p.S623C	15q15.1	C3N-01375	.	.	.	.	.	.	.	.	.	2.19	D	D	B	B	N	N	.	T	N	0.157	T	T	T	0.046	0.131	0.154	0.038	T	T	T	T	T	T	1.047	12.200	0.719	N	N	-0.983	0.422	-0.960	0.539	0.048	0.719	0.654	0.651	0.734	.	4.840	2.530	0.811	1.312	0.756	0.003	0.630	0.117	465	.	.	.	.	KNL1	55	0	169	17	0.0913978494623656	TRUE	TRUE
ENSG00000196557.13	.	BCM	GRCh38.p13	chr16	1201733	1201733	+	G	G	A	Missense_Mutation	SNP	ENST00000348261.11	exon9	c.G1283A	p.R428Q	exonic	ENSG00000196557.13	.	nonsynonymous SNV	ENSG00000196557.13:ENST00000348261.11:exon9:c.G1283A:p.R428Q	16p13.3	C3N-01375	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	M	D	D	0.597	D	D	D	0.636	0.266	0.943	.	T	D	D	D	D	D	4.254	29.200	0.999	D	D	0.704	7.176	0.564	5.796	1.000	0.696	0.547	0.723	0.563	.	3.860	3.860	9.708	1.073	0.665	1.000	0.975	0.965	940	Ion_transport_domain	.	.	.	CACNA1H	193	0	305	34	0.100294985250737	TRUE	NA
ENSG00000132510.10	.	BCM	GRCh38.p13	chr17	7847118	7847118	+	C	C	T	Missense_Mutation	SNP	ENST00000448097.6	exon10	c.C923T	p.S308L	exonic	ENSG00000132510.10	.	nonsynonymous SNV	ENSG00000132510.10:ENST00000448097.6:exon10:c.C923T:p.S308L	17p13.1	C3N-01375	0.0272	0.0024	0.1019	0.1759	0.0005	0.0035	0.0123	0.0169	rs2270516	2.19	D	T	B	B	N	P	L	T	N	0.098	T	T	.	0.039	.	.	0.102	T	T	T	T	T	T	2.400	22.100	0.969	D	N	-0.270	1.690	-0.072	2.128	0.960	0.672	0.702	0.723	0.636	.	5.360	4.390	1.362	1.022	0.596	0.422	0.997	0.997	298	.	.	.	ID=COSV54678248;OCCURENCE=4(meninges),2(soft_tissue),2(lung)	KDM6B	333	0	518	51	0.0896309314586995	TRUE	TRUE
ENSG00000141401.12	.	BCM	GRCh38.p13	chr18	12028094	12028094	+	C	C	T	Missense_Mutation	SNP	ENST00000269159.8	exon6	c.C542T	p.A181V	exonic	ENSG00000141401.12	.	nonsynonymous SNV	ENSG00000141401.12:ENST00000269159.8:exon6:c.C542T:p.A181V	18p11.21	C3N-01375	2.471e-05	0	0	0.0002	0	1.499e-05	0	0	rs369840633	2.20	D	T	B	B	D	N	L	T	N	0.205	T	T	T	0.073	0.482	0.402	0.478	T	T	T	T	T	T	2.347	21.800	0.990	N	N	-0.616	0.958	-0.594	1.055	1.000	0.732	0.670	0.744	0.655	.	5.840	2.680	0.978	0.073	0.599	0.533	0.100	0.567	895	.	.	.	.	IMPA2	152	0	252	21	0.0769230769230769	TRUE	NA
ENSG00000180777.14	.	BCM	GRCh38.p13	chr18	14777988	14777988	+	A	A	T	Missense_Mutation	SNP	ENST00000358984.9	exon10	c.A1333T	p.I445F	exonic	ENSG00000180777.14	.	nonsynonymous SNV	ENSG00000180777.14:ENST00000358984.9:exon10:c.A1333T:p.I445F	18p11.21	C3N-01375	.	.	.	.	.	.	.	.	.	0.17	T	T	.	.	.	N	N	T	N	0.052	T	T	T	0.010	0.390	0.076	0.144	T	T	T	T	T	T	-0.474	0.135	0.508	N	N	-1.276	0.178	-1.357	0.174	0.000	0.487	0.574	0.547	0.564	.	1.220	-1.740	-0.585	-0.931	-1.761	0.006	0.000	0.000	929	.	.	.	.	ANKRD30B	80	0	151	14	0.0848484848484849	TRUE	TRUE
ENSG00000185453.13	.	BCM	GRCh38.p13	chr19	48195574	48195574	+	G	G	C	Missense_Mutation	SNP	ENST00000328759.11	exon4	c.G1510C	p.D504H	exonic	ENSG00000185453.13	.	nonsynonymous SNV	ENSG00000185453.13:ENST00000328759.11:exon4:c.G1510C:p.D504H	19q13.33	C3N-01375	.	.	.	.	.	.	.	.	.	2.17	D	D	P	B	N	N	.	.	N	0.181	T	T	T	0.020	0.291	0.048	.	.	T	T	T	T	T	1.981	19.110	0.986	N	N	-0.503	1.171	-0.667	0.948	0.047	0.635	0.644	0.723	0.700	.	3.240	2.180	1.017	1.176	0.676	0.160	0.031	0.022	856	.	.	.	.	ZSWIM9	9	0	15	5	0.25	TRUE	NA
ENSG00000169933.15	.	BCM	GRCh38.p13	chrX	12716701	12716701	+	G	G	A	Missense_Mutation	SNP	ENST00000380682.5	exon15	c.G2242A	p.A748T	exonic	ENSG00000169933.15	.	nonsynonymous SNV	ENSG00000169933.15:ENST00000380682.5:exon15:c.G2242A:p.A748T	Xp22.2	C3N-01375	.	.	.	.	.	.	.	.	.	8.19	D	T	D	B	D	D	L	T	N	0.387	T	T	D	0.188	0.232	0.419	0.358	T	T	T	T	D	D	2.619	22.700	0.996	D	.	.	.	.	.	1.000	.	.	.	.	.	5.560	5.560	9.366	1.157	0.654	1.000	0.892	0.424	728	.	.	.	ID=COSV66215158;OCCURENCE=1(oesophagus),2(large_intestine),1(stomach)	FRMPD4	239	1	430	54	0.111570247933884	TRUE	TRUE
ENSG00000182872.16	.	BCM	GRCh38.p13	chrX	47179478	47179478	+	C	C	-	Nonsense_Mutation	SNP	ENST00000377604.8	exon9	c.884delC	p.S295*	exonic	ENSG00000182872.16	.	stopgain	ENSG00000182872.16:ENST00000377604.8:exon9:c.884delC:p.S295*	Xp11.3	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBM10	359	0	419	47	0.100858369098712	TRUE	TRUE
ENSG00000102057.10	.	BCM	GRCh38.p13	chrX	48969505	48969505	+	C	C	T	Missense_Mutation	SNP	ENST00000218176.4	exon1	c.G767A	p.R256H	exonic	ENSG00000102057.10	.	nonsynonymous SNV	ENSG00000102057.10:ENST00000218176.4:exon1:c.G767A:p.R256H	Xp11.23	C3N-01375	1.284e-05	0	0	0	0	2.347e-05	0	0	rs782327672	18.19	D	D	D	D	D	D	M	D	D	0.643	D	D	D	0.869	0.683	0.936	2.130	T	D	D	D	D	D	3.746	25.600	1.000	D	.	.	.	.	.	1.000	.	.	.	.	.	5.450	5.450	5.025	1.026	0.599	1.000	0.997	0.996	40	Ion_transport_domain	.	.	.	KCND1	253	0	357	50	0.122850122850123	TRUE	NA
ENSG00000196998.19	.	BCM	GRCh38.p13	chrX	49075904	49075904	+	C	C	G	Missense_Mutation	SNP	ENST00000376358.4	exon4	c.G172C	p.V58L	exonic	ENSG00000196998.19;ENSG00000288053.1	.	nonsynonymous SNV	ENSG00000288053.1:ENST00000376358.4:exon4:c.G172C:p.V58L,ENSG00000196998.19:ENST00000376372.9:exon7:c.G478C:p.V160L	Xp11.23	C3N-01375	.	.	.	.	.	.	.	.	.	10.19	D	D	B	B	U	D	M	T	D	0.535	T	T	D	0.158	0.551	0.931	0.634	D	T	T	T	D	D	1.809	17.800	0.991	D	.	.	.	.	.	1.000	.	.	.	.	.	3.760	3.760	5.685	1.018	0.539	1.000	0.993	0.979	13	.	.	.	.	WDR45	239	0	335	33	0.0896739130434783	TRUE	TRUE
ENSG00000183862.5	.	BCM	GRCh38.p13	chrX	151743565	151743565	+	C	C	-	Frame_Shift_Del	DEL	ENST00000329903.4	exon6	c.1062delC	p.F355Lfs*4	exonic	ENSG00000183862.5	.	frameshift deletion	ENSG00000183862.5:ENST00000329903.4:exon6:c.1062delC:p.F355Lfs*4	Xq28	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNGA2	185	0	265	31	0.10472972972973	TRUE	TRUE
ENSG00000130822.16	.	BCM	GRCh38.p13	chrX	153670503	153670503	+	C	C	T	Missense_Mutation	SNP	ENST00000340888.8	exon11	c.G986A	p.R329H	exonic	ENSG00000130822.16	.	nonsynonymous SNV	ENSG00000130822.16:ENST00000340888.8:exon11:c.G986A:p.R329H	Xq28	C3N-01375	1.399e-05	0	0	0	0	0	0	0.0001	rs782492056	3.19	D	D	B	B	N	N	L	T	N	0.122	T	T	D	0.036	0.223	0.796	0.682	T	T	T	T	T	T	1.609	16.430	0.983	N	.	.	.	.	.	0.994	.	.	.	.	.	3.730	1.920	-0.074	0.129	-0.202	0.000	0.173	0.054	23	.	.	.	.	PNCK	280	0	655	71	0.0977961432506887	TRUE	NA
ENSG00000080815.19	.	BCM	GRCh38.p13	chr14	73198130	73198133	+	GTAA	GTAA	-	Splice_Site	DEL	NA	NA	NA	NA	splicing	ENSG00000080815.19	.	.	.	14q24.2	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PSEN1	244	0	278	45	0.139318885448916	TRUE	TRUE
ENSG00000120278.16	.	BCM	GRCh38.p13	chr6	150809440	150809440	+	C	C	T	Silent	SNP	ENST00000358517.6	exon9	c.C1155T	p.F385F	exonic	ENSG00000120278.16	.	synonymous SNV	ENSG00000120278.16:ENST00000358517.6:exon9:c.C1155T:p.F385F	6q25.1	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEKHG1	227	0	299	32	0.0966767371601208	TRUE	TRUE
ENSG00000171316.12	.	BCM	GRCh38.p13	chr8	60801590	60801590	+	G	G	A	Silent	SNP	ENST00000423902.7	exon6	c.G2439A	p.K813K	exonic	ENSG00000171316.12	.	synonymous SNV	ENSG00000171316.12:ENST00000423902.7:exon6:c.G2439A:p.K813K	8q12.2	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHD7	95	0	249	34	0.120141342756184	TRUE	NA
ENSG00000137098.14	.	BCM	GRCh38.p13	chr9	35810264	35810264	+	T	T	G	Silent	SNP	ENST00000396638.7	exon6	c.A1246C	p.R416R	exonic	ENSG00000137098.14	.	synonymous SNV	ENSG00000137098.14:ENST00000396638.7:exon6:c.A1246C:p.R416R	9p13.3	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPAG8	201	0	285	34	0.106583072100313	TRUE	TRUE
ENSG00000130559.19	.	BCM	GRCh38.p13	chr9	135821613	135821613	+	G	G	A	Silent	SNP	ENST00000389532.9	exon11	c.C3048T	p.D1016D	exonic	ENSG00000130559.19	.	synonymous SNV	ENSG00000130559.19:ENST00000389532.9:exon11:c.C3048T:p.D1016D	9q34.3	C3N-01375	0.0018	0.0002	0.0003	0.0054	0	1.5e-05	0.0022	0.0099	rs117165081	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CAMSAP1	163	0	249	40	0.13840830449827	TRUE	NA
ENSG00000120659.15	.	BCM	GRCh38.p13	chr13	42600884	42600884	+	G	G	A	Silent	SNP	ENST00000398795.7	exon4	c.G435A	p.A145A	exonic	ENSG00000120659.15	.	synonymous SNV	ENSG00000120659.15:ENST00000398795.7:exon4:c.G435A:p.A145A	13q14.11	C3N-01375	8.239e-05	0	0	0.0007	0	4.496e-05	0	6.057e-05	rs775866494	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53480184;OCCURENCE=1(large_intestine)	TNFSF11	520	0	962	94	0.0890151515151515	TRUE	TRUE
ENSG00000176153.12	.	BCM	GRCh38.p13	chr14	64939554	64939554	+	G	G	-	Unknown	SNP	NA	NA	NA	NA	exonic	ENSG00000176153.12	.	unknown	UNKNOWN	14q23.3	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPX2	270	0	317	52	0.140921409214092	TRUE	TRUE
ENSG00000152467.10	.	BCM	GRCh38.p13	chr19	58052492	58052492	+	G	G	A	Silent	SNP	ENST00000282326.6	exon5	c.G468A	p.A156A	exonic	ENSG00000152467.10	.	synonymous SNV	ENSG00000152467.10:ENST00000282326.6:exon5:c.G468A:p.A156A	19q13.43	C3N-01375	3.314e-05	0	0	0	0	4.536e-05	0	6.059e-05	rs781127290	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56609495;OCCURENCE=1(biliary_tract),1(stomach)	ZSCAN1	240	0	400	36	0.0825688073394495	TRUE	TRUE
ENSG00000196562.14	.	BCM	GRCh38.p13	chr20	47665935	47665935	+	G	G	A	Silent	SNP	ENST00000359930.8	exon13	c.C1824T	p.N608N	exonic	ENSG00000196562.14	.	synonymous SNV	ENSG00000196562.14:ENST00000359930.8:exon13:c.C1824T:p.N608N	20q13.12	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63415168;OCCURENCE=2(liver),1(prostate),1(endometrium)	SULF2	246	0	303	33	0.0982142857142857	TRUE	TRUE
ENSG00000230612.3	.	BCM	GRCh38.p13	chr5	132706456	132706456	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000230612.3	.	.	.	5q31.1	C3N-01375	.	.	.	.	.	.	.	.	.	8.17	D	T	P	P	.	D	.	T	N	0.426	T	T	D	0.190	0.225	0.832	.	.	T	D	D	D	T	3.246	24.000	0.984	D	D	0.333	3.955	0.431	4.584	1.000	0.638	0.588	0.653	0.568	.	5.440	5.440	6.169	1.118	0.665	1.000	1.000	0.999	868	.	.	.	.	AC004039.1	103	0	252	14	0.0526315789473684	TRUE	TRUE
ENSG00000230969.2	.	BCM	GRCh38.p13	chr17	16988983	16988983	+	C	C	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000230969.2	.	.	.	17p11.2	C3N-01375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC02090	256	1	378	32	0.0780487804878049	TRUE	NA
ENSG00000179163.11	.	BCM	GRCh38.p13	chr1	23854398	23854398	+	C	C	G	Missense_Mutation	SNP	ENST00000374479.3	exon5	c.G931C	p.A311P	exonic	ENSG00000179163.11	.	nonsynonymous SNV	ENSG00000179163.11:ENST00000374479.3:exon5:c.G931C:p.A311P	1p36.11	C3N-03884	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.241	T	T	T	0.040	0.374	0.228	0.534	T	T	T	T	T	T	0.465	6.133	0.622	N	N	-1.424	0.107	-1.416	0.144	0.000	0.706	0.725	0.710	0.700	.	4.770	-2.500	0.119	-0.221	-0.187	0.013	0.050	0.284	623	.	.	.	.	FUCA1	314	0	515	61	0.105902777777778	TRUE	TRUE
ENSG00000198198.17	.	BCM	GRCh38.p13	chr1	43437200	43437200	+	C	C	T	Missense_Mutation	SNP	ENST00000634258.3	exon43	c.C6064T	p.R2022C	exonic	ENSG00000198198.17	.	nonsynonymous SNV	ENSG00000198198.17:ENST00000634258.3:exon43:c.C6064T:p.R2022C	1p34.2	C3N-03884	2.472e-05	0	8.637e-05	0	0	2.998e-05	0	0	rs766797004	14.19	D	D	D	D	D	D	M	.	D	0.588	T	T	T	0.233	0.399	0.378	1.096	D	T	D	D	D	D	4.080	27.600	0.997	D	N	0.596	5.888	0.607	6.313	1.000	0.672	0.702	0.602	0.636	.	5.860	5.860	2.369	1.026	0.599	1.000	0.534	0.407	776	.	.	.	ID=COSV65174056;OCCURENCE=1(skin)	SZT2	187	0	321	53	0.141711229946524	TRUE	TRUE
ENSG00000054392.13	.	BCM	GRCh38.p13	chr1	210674363	210674363	+	C	C	T	Missense_Mutation	SNP	ENST00000261458.8	exon12	c.C1466T	p.T489I	exonic	ENSG00000054392.13	.	nonsynonymous SNV	ENSG00000054392.13:ENST00000261458.8:exon12:c.C1466T:p.T489I	1q32.2	C3N-03884	1.65e-05	0	0	0	0.0002	1.5e-05	0	0	rs770356363	6.19	D	D	D	P	.	N	L	T	N	0.420	T	T	T	0.191	0.313	0.478	0.432	T	T	D	T	D	T	3.207	23.900	0.999	D	N	0.508	5.097	0.509	5.238	0.739	0.638	0.670	0.574	0.621	.	5.510	5.510	2.455	1.026	0.599	0.973	0.761	0.639	940	.	.	.	.	HHAT	202	0	377	42	0.100238663484487	TRUE	NA
ENSG00000091513.16	.	BCM	GRCh38.p13	chr3	133759184	133759184	+	C	C	-	Frame_Shift_Del	DEL	ENST00000402696.9	exon9	c.1058delC	p.P354Qfs*8	exonic	ENSG00000091513.16	.	frameshift deletion	ENSG00000091513.16:ENST00000402696.9:exon9:c.1058delC:p.P354Qfs*8	3q22.1	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TF	547	2	740	75	0.0920245398773006	TRUE	TRUE
ENSG00000109436.8	.	BCM	GRCh38.p13	chr4	140622521	140622521	+	C	C	T	Missense_Mutation	SNP	ENST00000442267.3	exon21	c.G3475A	p.D1159N	exonic	ENSG00000109436.8	.	nonsynonymous SNV	ENSG00000109436.8:ENST00000442267.3:exon21:c.G3475A:p.D1159N	4q31.21	C3N-03884	.	.	.	.	.	.	.	.	.	8.19	D	T	P	B	.	D	M	T	N	0.325	T	T	D	0.139	0.222	0.676	1.377	T	T	T	T	D	D	3.369	24.300	0.999	D	D	0.517	5.171	0.548	5.629	1.000	0.707	0.634	0.659	0.714	.	5.010	5.010	5.847	1.026	0.599	1.000	0.941	0.998	878	.	.	.	.	TBC1D9	368	0	610	63	0.0936106983655275	TRUE	TRUE
ENSG00000112902.12	.	BCM	GRCh38.p13	chr5	9063085	9063085	+	G	G	A	Missense_Mutation	SNP	ENST00000382496.10	exon18	c.C2320T	p.R774C	exonic	ENSG00000112902.12	.	nonsynonymous SNV	ENSG00000112902.12:ENST00000382496.10:exon18:c.C2320T:p.R774C	5p15.31	C3N-03884	.	.	.	.	.	.	.	.	.	11.20	D	D	D	P	D	D	L	T	D	0.792	T	T	T	0.230	.	0.678	1.068	T	T	T	D	D	D	4.059	27.400	0.999	D	D	0.348	4.039	0.339	3.949	1.000	0.615	0.617	0.659	0.564	.	5.650	3.800	4.763	0.161	0.676	1.000	0.823	0.919	838	.	.	.	.	SEMA5A	263	0	394	53	0.118568232662192	TRUE	NA
ENSG00000165671.20	.	BCM	GRCh38.p13	chr5	177246716	177246716	+	C	C	T	Nonsense_Mutation	SNP	ENST00000439151.6	exon10	c.C4417T	p.R1473X	exonic	ENSG00000165671.20	.	stopgain	ENSG00000165671.20:ENST00000439151.6:exon10:c.C4417T:p.R1473X	5q35.3	C3N-03884	.	.	.	.	.	.	.	.	rs587784117	5.6	.	.	.	.	D	A	.	.	.	0.865	.	.	.	.	.	.	.	.	.	D	D	.	.	7.448	38	0.998	D	N	0.643	6.387	0.493	5.100	1.000	0.707	0.725	0.725	0.723	.	5.650	3.750	1.330	1.026	0.599	1.000	1.000	0.990	923	.	.	.	ID=COSV61786888;OCCURENCE=1(stomach),1(upper_aerodigestive_tract)	NSD1	323	0	505	38	0.0699815837937385	TRUE	NA
ENSG00000204248.11	.	BCM	GRCh38.p13	chr6	33168520	33168520	+	C	C	T	Missense_Mutation	SNP	ENST00000374708.8	exon52	c.G3701A	p.R1234Q	exonic	ENSG00000204248.11	.	nonsynonymous SNV	ENSG00000204248.11:ENST00000374708.8:exon52:c.G3701A:p.R1234Q	6p21.32	C3N-03884	3.448e-05	0	0	0.0002	0	3.153e-05	0	0	rs372143434	11.16	T	T	.	.	D	D	.	D	D	0.558	D	D	D	0.621	.	0.819	0.388	T	T	T	D	D	.	3.936	26.600	0.999	D	D	0.412	4.416	0.393	4.306	0.999	0.615	0.588	0.659	0.568	.	4.250	4.250	3.778	1.014	0.585	1.000	0.996	0.859	830	.	.	.	.	COL11A2	391	0	645	57	0.0811965811965812	TRUE	NA
ENSG00000106571.14	.	BCM	GRCh38.p13	chr7	41965069	41965069	+	G	G	A	Missense_Mutation	SNP	ENST00000395925.8	exon15	c.C4004T	p.P1335L	exonic	ENSG00000106571.14	.	nonsynonymous SNV	ENSG00000106571.14:ENST00000395925.8:exon15:c.C4004T:p.P1335L	7p14.1	C3N-03884	8.339e-06	9.866e-05	0	0	0	0	0	0	rs201047754	3.20	T	T	B	B	N	D	N	T	N	0.130	T	T	D	0.034	.	0.202	0.296	T	T	T	T	T	T	1.002	11.650	0.538	D	N	-0.685	0.838	-0.570	1.092	0.508	0.707	0.574	0.725	0.636	.	5.330	1.290	1.490	0.198	-0.124	0.949	0.065	0.563	932	.	.	.	ID=COSV67886463;OCCURENCE=1(stomach)	GLI3	346	0	524	69	0.116357504215852	TRUE	TRUE
ENSG00000106245.11	.	BCM	GRCh38.p13	chr7	99419424	99419424	+	C	C	A	Missense_Mutation	SNP	ENST00000222969.10	exon6	c.C418A	p.R140S	exonic	ENSG00000106245.11	.	nonsynonymous SNV	ENSG00000106245.11:ENST00000222969.10:exon6:c.C418A:p.R140S	7q22.1	C3N-03884	.	.	.	.	.	.	.	.	.	10.19	D	T	B	B	D	D	M	.	D	0.802	T	T	T	0.287	0.620	0.343	0.827	T	T	D	D	D	D	2.281	21.400	0.996	D	N	0.018	2.574	0.023	2.440	0.999	0.672	0.698	0.702	0.711	.	4.930	2.020	1.216	0.084	0.581	1.000	0.972	0.914	400	BUD31/G10-related,_conserved_site	.	.	.	BUD31	263	0	439	50	0.102249488752556	TRUE	TRUE
ENSG00000122783.16	.	BCM	GRCh38.p13	chr7	135167799	135167799	+	G	G	A	Missense_Mutation	SNP	ENST00000393114.7	exon3	c.C146T	p.A49V	exonic	ENSG00000122783.16	.	nonsynonymous SNV	ENSG00000122783.16:ENST00000393114.7:exon3:c.C146T:p.A49V	7q33	C3N-03884	5.779e-05	0.0007	0	0	0	0	0	0	rs140271713	0.7	.	.	.	.	.	N	.	.	.	.	.	.	T	.	.	.	.	.	.	T	T	T	.	0.276	4.009	0.595	N	N	-1.113	0.295	-1.156	0.321	1.000	0.646	0.672	0.702	0.723	.	4.930	1.110	0.343	-0.583	-1.560	0.000	0.000	0.000	485	.	.	.	.	CYREN	212	0	344	22	0.0601092896174863	TRUE	NA
ENSG00000183779.7	.	BCM	GRCh38.p13	chr8	37698568	37698568	+	C	C	T	Missense_Mutation	SNP	ENST00000331569.6	exon2	c.C1667T	p.A556V	exonic	ENSG00000183779.7	.	nonsynonymous SNV	ENSG00000183779.7:ENST00000331569.6:exon2:c.C1667T:p.A556V	8p11.23	C3N-03884	.	.	.	.	.	.	.	.	.	7.20	D	T	D	B	N	D	L	T	N	0.262	T	T	D	0.143	0.102	0.421	.	T	T	T	T	D	T	3.464	24.600	0.998	D	D	0.211	3.350	0.251	3.443	1.000	0.651	0.627	0.504	0.684	.	3.520	3.520	5.826	0.950	0.452	1.000	0.996	0.991	675	.	.	.	.	ZNF703	104	1	223	37	0.142307692307692	TRUE	NA
ENSG00000170961.7	.	BCM	GRCh38.p13	chr8	121628856	121628856	+	T	T	A	Missense_Mutation	SNP	ENST00000303924.5	exon2	c.A485T	p.E162V	exonic	ENSG00000170961.7	.	nonsynonymous SNV	ENSG00000170961.7:ENST00000303924.5:exon2:c.A485T:p.E162V	8q24.13	C3N-03884	.	.	.	.	.	.	.	.	.	8.20	D	D	B	B	D	D	L	T	N	0.399	T	T	D	0.181	0.590	0.117	0.873	T	T	T	T	D	T	2.797	23.000	0.972	D	D	-0.081	2.235	0.078	2.645	1.000	0.554	0.574	0.618	0.564	.	5.870	5.870	6.269	1.138	0.660	1.000	0.963	0.177	838	.	.	.	.	HAS2	409	0	552	114	0.171171171171171	TRUE	TRUE
ENSG00000050555.18	.	BCM	GRCh38.p13	chr9	131026366	131026366	+	G	G	A	Missense_Mutation	SNP	ENST00000361069.9	exon2	c.G455A	p.R152H	exonic	ENSG00000050555.18	.	nonsynonymous SNV	ENSG00000050555.18:ENST00000361069.9:exon2:c.G455A:p.R152H	9q34.12	C3N-03884	6.632e-05	0	0	0	0	4.533e-05	0	0.0003	rs773185472	1.20	T	T	B	B	N	N	N	T	N	0.165	T	T	D	0.236	0.725	0.450	0.194	T	T	T	T	T	T	-0.505	0.116	0.881	N	N	-1.593	0.057	-1.652	0.062	1.000	0.696	0.590	0.723	0.586	.	5.680	-5.150	-1.559	-2.507	-1.689	0.000	0.000	0.003	428	Laminin,_N-terminal	.	.	ID=COSV63089505;OCCURENCE=1(large_intestine)	LAMC3	494	0	625	152	0.195624195624196	TRUE	TRUE
ENSG00000172661.18	.	BCM	GRCh38.p13	chr10	45784666	45784666	+	C	C	-	Frame_Shift_Del	DEL	ENST00000374362.6	exon24	c.2580delC	p.L861Ffs*11	exonic	ENSG00000172661.18	.	frameshift deletion	ENSG00000172661.18:ENST00000374362.6:exon24:c.2580delC:p.L861Ffs*11	10q11.22	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WASHC2C	125	0	184	25	0.119617224880383	NA	TRUE
ENSG00000174672.16	.	BCM	GRCh38.p13	chr11	1454504	1454504	+	T	T	A	Missense_Mutation	SNP	ENST00000528841.6	exon16	c.T1564A	p.F522I	exonic	ENSG00000174672.16	.	nonsynonymous SNV	ENSG00000174672.16:ENST00000528841.6:exon16:c.T1564A:p.F522I	11p15.5	C3N-03884	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	U	D	M	D	D	0.940	T	T	D	0.887	0.664	0.917	1.603	D	D	D	D	D	D	4.376	31	0.988	D	D	0.324	3.904	0.307	3.760	0.663	0.696	0.588	0.723	0.563	.	3.570	3.570	5.940	1.086	0.609	1.000	0.999	0.998	976	.	.	.	.	BRSK2	183	0	355	42	0.105793450881612	TRUE	TRUE
ENSG00000166349.9	.	BCM	GRCh38.p13	chr11	36573933	36573933	+	C	C	T	Missense_Mutation	SNP	ENST00000299440.5	exon2	c.C629T	p.S210F	exonic	ENSG00000166349.9	.	nonsynonymous SNV	ENSG00000166349.9:ENST00000299440.5:exon2:c.C629T:p.S210F	11p12	C3N-03884	.	.	.	.	.	.	.	.	rs147440161	5.20	D	T	P	P	N	N	M	T	N	0.182	T	T	D	0.168	0.363	0.809	0.277	T	T	T	T	D	D	1.998	19.240	0.994	N	N	0.379	4.213	0.341	3.967	1.000	0.554	0.563	0.618	0.586	.	5.900	5.900	0.467	1.026	0.599	0.002	0.983	0.962	485	RAG1_importin-binding	.	.	ID=COSV55029145;OCCURENCE=1(skin)	RAG1	206	0	320	46	0.12568306010929	TRUE	TRUE
ENSG00000181767.3	.	BCM	GRCh38.p13	chr11	56105512	56105512	+	T	T	A	Missense_Mutation	SNP	ENST00000641311.1	exon2	c.T470A	p.F157Y	exonic	ENSG00000181767.3	.	nonsynonymous SNV	ENSG00000181767.3:ENST00000641311.1:exon2:c.T470A:p.F157Y	11q12.1	C3N-03884	.	.	.	.	.	.	.	.	.	0.20	T	T	P	P	N	N	L	T	N	0.154	T	T	T	0.027	0.364	0.284	0.322	T	T	T	T	T	T	1.447	15.400	0.977	N	N	-0.440	1.297	-0.683	0.925	0.000	0.487	0.574	0.574	0.564	.	3.350	1.030	-0.224	0.725	0.458	0.000	0.006	0.005	150	GPCR,_rhodopsin-like,_7TM	.	.	.	OR8H2	253	0	337	26	0.0716253443526171	NA	TRUE
ENSG00000168066.20	.	BCM	GRCh38.p13	chr11	64766092	64766092	+	G	G	A	Missense_Mutation	SNP	ENST00000377390.7	exon13	c.C1646T	p.A549V	exonic	ENSG00000168066.20	.	nonsynonymous SNV	ENSG00000168066.20:ENST00000377390.7:exon13:c.C1646T:p.A549V	11q13.1	C3N-03884	4.291e-05	0	0	0	0	7.787e-05	0	0	rs754963575	5.18	D	T	B	B	.	D	N	T	N	0.339	T	T	D	0.034	.	0.401	.	.	T	T	T	T	D	2.219	21.000	0.981	D	N	0.158	3.124	0.290	3.657	1.000	0.742	0.702	0.775	0.714	.	5.300	5.300	2.917	0.988	0.584	1.000	1.000	0.997	401	.	.	.	.	SF1	407	0	711	94	0.116770186335404	TRUE	NA
ENSG00000174807.4	.	BCM	GRCh38.p13	chr11	66316822	66316822	+	C	C	T	Missense_Mutation	SNP	ENST00000311330.4	exon1	c.G206A	p.R69H	exonic	ENSG00000174807.4	.	nonsynonymous SNV	ENSG00000174807.4:ENST00000311330.4:exon1:c.G206A:p.R69H	11q13.2	C3N-03884	7.752e-05	0.0002	0	0	0	8.347e-05	0	9.048e-05	rs751114440	3.20	T	T	D	P	N	N	N	T	N	0.297	T	T	D	0.082	0.528	0.427	1.178	D	T	T	T	T	T	2.094	19.970	0.998	N	N	-0.476	1.224	-0.570	1.092	1.000	0.609	0.547	0.769	0.563	.	3.750	2.830	-0.182	0.952	0.511	0.000	0.836	0.615	85	C-type_lectin-like	.	.	ID=COSV60936700;OCCURENCE=1(prostate)	CD248	123	0	236	28	0.106060606060606	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-03884	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	279	0	434	55	0.112474437627812	TRUE	TRUE
ENSG00000167548.15	.	BCM	GRCh38.p13	chr12	49040778	49040778	+	-	NA	G	Frame_Shift_Ins	NA	ENST00000301067.11	exon31	c.6991dupC	p.L2331Pfs*46	exonic	ENSG00000167548.15	.	frameshift insertion	ENSG00000167548.15:ENST00000301067.11:exon31:c.6991dupC:p.L2331Pfs*46	12q13.12	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KMT2D	NA	NA	NA	NA	NA	NA	NA
ENSG00000006327.14	.	BCM	GRCh38.p13	chr16	3021641	3021641	+	T	T	G	Missense_Mutation	SNP	ENST00000326577.9	exon3	c.T286G	p.S96A	exonic	ENSG00000006327.14	.	nonsynonymous SNV	ENSG00000006327.14:ENST00000326577.9:exon3:c.T286G:p.S96A	16p13.3	C3N-03884	.	.	.	.	.	.	.	.	.	4.18	D	D	P	P	N	N	L	.	D	0.364	T	T	T	0.066	0.430	0.261	0.926	.	T	T	T	D	T	2.921	23.300	0.662	N	N	-0.126	2.093	-0.099	2.051	1.000	0.564	0.552	0.522	0.562	.	4.580	3.450	1.738	1.138	0.665	0.998	1.000	0.999	740	.	.	.	.	TNFRSF12A	139	0	265	25	0.0862068965517241	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674953	7674953	+	T	T	C	Missense_Mutation	SNP	ENST00000269305.8	exon6	c.A578G	p.H193R	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon6:c.A578G:p.H193R	17p13.1	C3N-03884	.	.	.	.	.	.	.	.	rs786201838	19.20	D	D	D	D	D	D	M	D	D	0.964	D	D	D	0.884	0.987	0.998	1.832	T	D	D	D	D	D	4.068	27.500	0.988	D	D	0.482	4.899	0.343	3.977	0.963	0.722	0.698	0.702	0.735	.	5.410	4.330	8.017	1.138	0.665	1.000	0.997	0.987	433	p53,_DNA-binding_domain	.	.	ID=COSV52662414;OCCURENCE=2(salivary_gland),31(breast),10(liver),14(oesophagus),8(large_intestine),15(central_nervous_system),3(biliary_tract),19(ovary),10(stomach),18(haematopoietic_and_lymphoid_tissue),1(kidney),6(urinary_tract),1(soft_tissue),4(pancreas),2(prostate),19(lung),3(thyroid),6(upper_aerodigestive_tract),5(endometrium)	TP53	465	0	623	108	0.147742818057456	TRUE	TRUE
ENSG00000141314.13	.	BCM	GRCh38.p13	chr17	32321077	32321077	+	G	G	A	Missense_Mutation	SNP	ENST00000269051.9	exon9	c.G1063A	p.V355M	exonic	ENSG00000141314.13	.	nonsynonymous SNV	ENSG00000141314.13:ENST00000269051.9:exon9:c.G1063A:p.V355M	17q11.2	C3N-03884	2.471e-05	0	8.64e-05	0	0	1.499e-05	0	6.056e-05	rs749663091	10.20	D	D	D	D	D	D	L	T	N	0.831	T	T	D	0.282	0.503	0.570	0.867	T	T	T	T	T	D	3.862	26.100	0.999	D	D	0.563	5.567	0.578	5.964	1.000	0.706	0.588	0.710	0.613	.	5.810	4.820	6.291	1.069	0.660	1.000	1.000	0.998	941	Peptidase_S54,_rhomboid_domain	.	.	.	RHBDL3	604	0	980	92	0.0858208955223881	TRUE	NA
ENSG00000161664.7	.	BCM	GRCh38.p13	chr17	44176922	44176922	+	G	G	A	Missense_Mutation	SNP	ENST00000293414.6	exon3	c.G754A	p.A252T	exonic	ENSG00000161664.7	.	nonsynonymous SNV	ENSG00000161664.7:ENST00000293414.6:exon3:c.G754A:p.A252T	17q21.31	C3N-03884	0	0	0	0	0	0	0	0	rs777379847	7.20	D	T	D	P	N	D	L	T	N	0.297	T	T	D	0.117	0.183	0.599	0.687	D	T	T	T	D	T	2.971	23.400	0.998	D	N	0.328	3.928	0.276	3.579	1.000	0.701	0.577	0.717	0.492	.	5.220	4.220	3.915	1.088	0.588	0.989	0.918	0.047	389	Ankyrin_repeat-containing_domain	.	.	.	ASB16	234	0	379	55	0.126728110599078	TRUE	NA
ENSG00000081913.14	.	BCM	GRCh38.p13	chr18	62716918	62716918	+	C	C	T	Missense_Mutation	SNP	ENST00000262719.10	exon1	c.C1235T	p.S412L	exonic	ENSG00000081913.14	.	nonsynonymous SNV	ENSG00000081913.14:ENST00000262719.10:exon1:c.C1235T:p.S412L	18q21.33	C3N-03884	.	.	.	.	.	.	.	.	.	1.17	T	T	.	.	.	N	L	T	N	0.124	T	T	D	0.005	0.156	0.043	0.193	T	T	T	T	T	T	0.184	2.941	0.954	N	N	-1.010	0.394	-1.154	0.323	1.000	0.437	0.219	0.474	0.604	.	2.690	-0.396	-1.289	0.005	-0.301	0.000	0.001	0.001	940	.	.	.	.	PHLPP1	392	0	608	50	0.0759878419452888	TRUE	NA
ENSG00000081913.14	.	BCM	GRCh38.p13	chr18	62716923	62716923	+	C	C	T	Nonsense_Mutation	SNP	ENST00000262719.10	exon1	c.C1240T	p.Q414X	exonic	ENSG00000081913.14	.	stopgain	ENSG00000081913.14:ENST00000262719.10:exon1:c.C1240T:p.Q414X	18q21.33	C3N-03884	.	.	.	.	.	.	.	.	.	1.5	.	.	.	.	.	A	.	.	.	0.243	.	.	.	.	.	.	.	.	.	T	T	.	.	5.236	33	0.982	N	N	-0.376	1.435	-0.789	0.774	1.000	0.437	0.219	0.474	0.604	.	2.910	-2.310	-0.112	-1.010	-1.105	0.000	0.000	0.003	940	.	.	.	.	PHLPP1	422	0	673	58	0.079343365253078	TRUE	TRUE
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8073184	8073184	+	C	C	T	Missense_Mutation	SNP	ENST00000600128.6	exon62	c.G7816A	p.G2606R	exonic	ENSG00000142449.13	.	nonsynonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon62:c.G7816A:p.G2606R	19p13.2	C3N-03884	4.17e-05	0.0004	0	0	0	0	0	6.058e-05	rs371456112	3.20	T	T	B	B	N	D	N	T	D	0.369	T	T	D	0.036	.	0.325	0.440	T	T	T	T	T	T	0.554	7.058	0.915	N	N	-0.996	0.409	-1.037	0.444	1.000	0.718	0.316	0.571	0.564	.	4.390	0.975	0.855	-0.916	-0.171	0.006	0.027	0.035	734	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	ID=COSV99561151;OCCURENCE=1(endometrium)	FBN3	276	0	415	64	0.133611691022964	TRUE	NA
ENSG00000197360.9	.	BCM	GRCh38.p13	chr19	22403446	22403446	+	C	C	T	Missense_Mutation	SNP	ENST00000357774.9	exon2	c.G97A	p.A33T	exonic	ENSG00000197360.9	.	nonsynonymous SNV	ENSG00000197360.9:ENST00000357774.9:exon2:c.G97A:p.A33T	19p12	C3N-03884	8.274e-06	0	0	0.0001	0	0	0	0	rs759221666	3.19	D	T	D	P	.	N	L	T	D	0.110	T	T	T	0.076	0.759	0.210	0.856	T	T	T	T	T	T	0.199	3.111	0.993	N	N	-0.469	1.239	-0.764	0.808	0.000	0.487	0.574	0.574	0.564	.	1.060	-0.855	-2.724	-1.487	-1.821	0.006	0.000	0.000	988	Krueppel-associated_box	.	.	ID=COSV63337859;OCCURENCE=1(breast)	ZNF98	264	0	418	49	0.104925053533191	NA	TRUE
ENSG00000171735.19	.	BCM	GRCh38.p13	chr1	7664308	7664308	+	C	C	T	Silent	SNP	ENST00000303635.12	exon9	c.C1761T	p.S587S	exonic	ENSG00000171735.19	.	synonymous SNV	ENSG00000171735.19:ENST00000303635.12:exon9:c.C1761T:p.S587S	1p36.23	C3N-03884	5.052e-05	0.0005	0	0	0	1.539e-05	0	0	rs369901419	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CAMTA1	256	0	510	30	0.0555555555555556	TRUE	NA
ENSG00000131379.10	.	BCM	GRCh38.p13	chr3	14683073	14683073	+	T	T	A	Silent	SNP	ENST00000253697.8	exon3	c.T360A	p.S120S	exonic	ENSG00000131379.10	.	synonymous SNV	ENSG00000131379.10:ENST00000253697.8:exon3:c.T360A:p.S120S	3p25.1	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C3orf20	266	0	445	57	0.113545816733068	TRUE	TRUE
ENSG00000047188.16	.	BCM	GRCh38.p13	chr5	113548644	113548644	+	C	C	G	Silent	SNP	ENST00000161863.9	exon11	c.C1599G	p.V533V	exonic	ENSG00000047188.16	.	synonymous SNV	ENSG00000047188.16:ENST00000161863.9:exon11:c.C1599G:p.V533V	5q22.2	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	YTHDC2	172	0	262	30	0.102739726027397	TRUE	TRUE
ENSG00000226979.8	.	BCM	GRCh38.p13	chr6	31573399	31573399	+	C	C	T	Silent	SNP	ENST00000454783.5	exon4	c.C324T	p.F108F	exonic	ENSG00000226979.8	.	synonymous SNV	ENSG00000226979.8:ENST00000454783.5:exon4:c.C324T:p.F108F	6p21.33	C3N-03884	.	.	.	.	.	.	.	.	rs372799652	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV69304547;OCCURENCE=1(large_intestine),1(central_nervous_system)	LTA	346	0	607	58	0.087218045112782	TRUE	TRUE
ENSG00000112238.12	.	BCM	GRCh38.p13	chr6	99613127	99613127	+	C	C	T	Silent	SNP	ENST00000369215.5	exon4	c.C492T	p.G164G	exonic	ENSG00000112238.12	.	synonymous SNV	ENSG00000112238.12:ENST00000369215.5:exon4:c.C492T:p.G164G	6q16.2	C3N-03884	4.26e-05	0	0	0	0.0002	6.205e-05	0	0	rs780474604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRDM13	425	0	681	91	0.117875647668394	TRUE	NA
ENSG00000034053.14	.	BCM	GRCh38.p13	chr15	29054487	29054487	+	C	C	A	Silent	SNP	ENST00000558402.5	exon5	c.C603A	p.A201A	exonic	ENSG00000034053.14	.	synonymous SNV	ENSG00000034053.14:ENST00000558402.5:exon5:c.C603A:p.A201A	15q13.1	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	APBA2	672	0	1047	133	0.11271186440678	TRUE	TRUE
ENSG00000086967.10	.	BCM	GRCh38.p13	chr19	50454094	50454094	+	G	G	A	Silent	SNP	ENST00000357701.6	exon17	c.G1824A	p.A608A	exonic	ENSG00000086967.10	.	synonymous SNV	ENSG00000086967.10:ENST00000357701.6:exon17:c.G1824A:p.A608A	19q13.33	C3N-03884	4.361e-05	0.0005	0	0	0	0	0	0	rs373184181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63093208;OCCURENCE=1(large_intestine),1(biliary_tract),1(skin),1(endometrium)	MYBPC2	323	0	545	58	0.0961857379767828	TRUE	TRUE
ENSG00000100982.12	.	BCM	GRCh38.p13	chr20	45946076	45946076	+	G	G	A	Silent	SNP	ENST00000372409.8	exon13	c.G1389A	p.R463R	exonic	ENSG00000100982.12	.	synonymous SNV	ENSG00000100982.12:ENST00000372409.8:exon13:c.G1389A:p.R463R	20q13.12	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCIF1	353	1	554	64	0.103559870550162	TRUE	TRUE
ENSG00000145868.17	.	BCM	GRCh38.p13	chr5	148451269	148451269	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000145868.17;ENSG00000164270.18	dist=8433;dist=30278	.	.	5q32	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBXO38	244	0	346	51	0.128463476070529	TRUE	TRUE
ENSG00000137731.14	.	BCM	GRCh38.p13	chr11	117822486	117822489	+	GAAA	GAAA	-	Intron	DEL	NA	NA	NA	NA	intronic	ENSG00000137731.14;ENSG00000255245.4	.	.	.	11q23.3	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FXYD2	262	0	352	34	0.0880829015544041	TRUE	NA
ENSG00000197503.4	.	BCM	GRCh38.p13	chr12	24584040	24584040	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000197503.4;ENSG00000256852.1	.	.	.	12p12.1	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC00477	137	0	222	21	0.0864197530864197	TRUE	NA
ENSG00000182732.18	.	BCM	GRCh38.p13	chr14	71990596	71990596	+	T	T	-	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000182732.18	.	.	.	14q24.2	C3N-03884	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RGS6	133	0	177	23	0.115	TRUE	NA
ENSG00000137948.18	.	BCM	GRCh38.p13	chr1	91976319	91976319	+	G	G	A	Missense_Mutation	SNP	ENST00000362005.7	exon6	c.G499A	p.A167T	exonic	ENSG00000137948.18	.	nonsynonymous SNV	ENSG00000137948.18:ENST00000362005.7:exon6:c.G499A:p.A167T	1p22.1	C3N-01168	0.0024	0.0004	0.0003	0	0.0005	0.0028	0	0.0060	rs112246679	0.20	T	T	B	B	N	N	L	T	N	0.149	T	T	T	0.024	.	0.371	0.077	T	T	T	T	T	T	0.433	5.794	0.793	N	N	-0.895	0.526	-0.928	0.582	0.027	0.487	0.574	0.574	0.542	.	4.990	2.010	0.418	-0.126	-0.161	0.000	0.004	0.014	623	.	.	.	.	BRDT	87	0	239	21	0.0807692307692308	TRUE	NA
ENSG00000143373.18	.	BCM	GRCh38.p13	chr1	151290535	151290535	+	G	G	T	Missense_Mutation	SNP	ENST00000324048.9	exon9	c.G3181T	p.G1061W	exonic	ENSG00000143373.18	.	nonsynonymous SNV	ENSG00000143373.18:ENST00000324048.9:exon9:c.G3181T:p.G1061W	1q21.3	C3N-01168	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	U	D	M	T	D	0.467	T	T	T	0.222	0.392	0.180	1.100	T	T	T	T	D	T	3.922	26.500	0.992	D	D	0.548	5.428	0.511	5.264	1.000	0.672	0.702	0.607	0.636	.	5.090	5.090	4.594	1.176	0.676	1.000	0.761	0.462	91	.	.	.	.	ZNF687	100	0	316	68	0.177083333333333	TRUE	TRUE
ENSG00000160716.6	.	BCM	GRCh38.p13	chr1	154571959	154571959	+	G	G	A	Missense_Mutation	SNP	ENST00000368476.4	exon5	c.G1136A	p.R379H	exonic	ENSG00000160716.6	.	nonsynonymous SNV	ENSG00000160716.6:ENST00000368476.4:exon5:c.G1136A:p.R379H	1q21.3	C3N-01168	.	.	.	.	.	.	.	.	.	4.19	T	T	B	B	.	D	N	D	N	0.198	T	T	D	0.093	0.398	0.676	1.640	D	T	T	T	T	T	1.457	15.460	0.992	N	N	-0.794	0.663	-0.761	0.813	1.000	0.581	0.547	0.576	0.542	.	3.970	3.050	2.592	1.089	0.511	0.079	0.133	0.150	445	Neurotransmitter-gated_ion-channel_transmembrane_domain	.	.	.	CHRNB2	85	0	679	62	0.0836707152496626	TRUE	NA
ENSG00000154358.21	.	BCM	GRCh38.p13	chr1	228287847	228287847	+	G	G	A	Missense_Mutation	SNP	ENST00000422127.5	exon36	c.G9698A	p.R3233H	exonic	ENSG00000154358.21	.	nonsynonymous SNV	ENSG00000154358.21:ENST00000422127.5:exon36:c.G9698A:p.R3233H	1q42.13	C3N-01168	.	.	.	.	.	.	.	.	.	7.20	D	D	B	B	D	N	M	T	D	0.185	T	T	D	0.241	0.549	0.671	0.129	T	T	T	T	D	T	1.280	14.240	0.892	N	N	-0.436	1.307	-0.440	1.301	0.010	0.696	0.588	0.723	0.621	.	5.060	4.150	0.050	1.172	0.672	0.003	0.214	0.050	425	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV104628517;OCCURENCE=1(large_intestine)	OBSCN	406	0	938	83	0.0812928501469148	TRUE	TRUE
ENSG00000186487.20	.	BCM	GRCh38.p13	chr2	1887569	1887569	+	C	C	T	Missense_Mutation	SNP	ENST00000647738.2	exon17	c.G2561A	p.R854K	exonic	ENSG00000186487.20	.	nonsynonymous SNV	ENSG00000186487.20:ENST00000647738.2:exon17:c.G2561A:p.R854K	2p25.3	C3N-01168	.	.	.	.	.	.	.	.	.	5.16	.	.	P	P	D	D	L	.	.	.	T	T	T	0.097	0.406	0.271	1.394	T	T	T	T	D	T	2.915	23.200	0.992	D	D	0.275	3.651	0.400	4.362	1.000	0.403	0.547	0.578	0.613	.	5.550	5.550	7.505	1.026	0.599	1.000	0.991	0.957	768	Myelin_transcription_factor_1	.	.	.	MYT1L	286	0	498	55	0.0994575045207957	TRUE	TRUE
ENSG00000115540.15	.	BCM	GRCh38.p13	chr2	197516129	197516129	+	C	C	A	Missense_Mutation	SNP	ENST00000323303.9	exon1	c.C43A	p.P15T	exonic	ENSG00000115540.15	.	nonsynonymous SNV	ENSG00000115540.15:ENST00000323303.9:exon1:c.C43A:p.P15T	2q33.1	C3N-01168	.	.	.	.	.	.	.	.	.	13.18	D	D	D	P	D	D	M	.	D	0.623	T	T	D	0.250	0.550	0.320	1.858	.	D	T	T	D	D	3.902	26.400	0.988	D	D	0.499	5.026	0.472	4.917	1.000	0.442	0.522	0.522	0.562	.	4.600	3.700	4.982	0.962	0.524	1.000	1.000	0.990	482	.	.	.	.	MOB4	156	0	475	101	0.175347222222222	TRUE	TRUE
ENSG00000121879.5	.	BCM	GRCh38.p13	chr3	179218294	179218294	+	G	G	A	Missense_Mutation	SNP	ENST00000263967.4	exon10	c.G1624A	p.E542K	exonic	ENSG00000121879.5	.	nonsynonymous SNV	ENSG00000121879.5:ENST00000263967.4:exon10:c.G1624A:p.E542K	3q26.32	C3N-01168	.	.	.	.	.	.	.	.	rs121913273	14.20	D	T	D	D	D	D	L	T	N	0.957	T	T	D	0.439	0.719	0.877	2.798	D	D	D	D	D	D	4.466	32	0.999	D	D	0.612	6.048	0.672	7.254	1.000	0.732	0.710	0.659	0.728	.	5.780	5.780	9.602	1.176	0.618	1.000	1.000	0.997	799	Phosphoinositide_3-kinase,_accessory_(PIK)_domain	.	.	ID=COSV55873227;OCCURENCE=11(salivary_gland),611(breast),8(penis),12(liver),2(genital_tract),29(oesophagus),56(cervix),462(large_intestine),25(central_nervous_system),11(biliary_tract),6(vulva),39(ovary),1(bone),4(NS),4(haematopoietic_and_lymphoid_tissue),40(stomach),16(soft_tissue),14(kidney),110(urinary_tract),5(pancreas),5(gastrointestinal_tract_(site_indeterminate)),1(pituitary),34(skin),8(prostate),68(lung),27(thyroid),75(upper_aerodigestive_tract),3(testis),1(thymus),3(small_intestine),81(endometrium)	PIK3CA	104	0	304	29	0.0870870870870871	NA	TRUE
ENSG00000145194.18	.	BCM	GRCh38.p13	chr3	184276535	184276535	+	G	G	A	Missense_Mutation	SNP	ENST00000357474.9	exon2	c.G94A	p.V32I	exonic	ENSG00000145194.18	.	nonsynonymous SNV	ENSG00000145194.18:ENST00000357474.9:exon2:c.G94A:p.V32I	3q27.1	C3N-01168	.	.	.	.	.	.	.	.	rs942717079	3.15	T	T	.	.	N	N	.	D	N	0.199	T	T	D	0.150	0.137	0.414	.	.	.	T	T	D	T	1.627	16.540	0.993	N	N	-0.657	0.886	-0.566	1.097	0.589	0.447	0.563	0.504	0.530	.	3.610	1.650	1.617	1.167	0.676	0.009	0.941	0.996	820	.	.	.	ID=COSV104662790;OCCURENCE=1(large_intestine)	ECE2	254	0	654	88	0.118598382749326	TRUE	NA
ENSG00000035928.16	.	BCM	GRCh38.p13	chr4	39316991	39316991	+	C	C	T	Missense_Mutation	SNP	ENST00000381897.5	exon10	c.G1127A	p.R376H	exonic	ENSG00000035928.16	.	nonsynonymous SNV	ENSG00000035928.16:ENST00000381897.5:exon10:c.G1127A:p.R376H	4p14	C3N-01168	2.474e-05	0.0002	0	0	0	1.5e-05	0	0	rs374549255	12.20	D	D	D	D	D	D	M	T	D	0.360	T	T	T	0.356	.	0.743	0.705	T	T	T	T	D	D	4.235	29.000	1.000	D	D	0.804	8.851	0.804	10.246	1.000	0.732	0.725	0.744	0.714	.	5.930	5.930	5.649	1.026	0.549	1.000	0.998	0.995	410	.	.	.	ID=COSV62899615;OCCURENCE=1(breast),3(stomach)	RFC1	167	0	385	38	0.0898345153664303	TRUE	TRUE
ENSG00000155511.18	.	BCM	GRCh38.p13	chr5	153677055	153677055	+	G	G	A	Missense_Mutation	SNP	ENST00000285900.10	exon7	c.G923A	p.R308Q	exonic	ENSG00000155511.18	.	nonsynonymous SNV	ENSG00000155511.18:ENST00000285900.10:exon7:c.G923A:p.R308Q	5q33.2	C3N-01168	8.537e-06	0	0	0	0	0	0	7.272e-05	rs760982517	9.20	T	T	D	D	D	D	L	T	N	0.744	T	T	D	0.237	0.781	0.774	0.781	T	T	T	T	D	D	3.742	25.600	1.000	D	D	0.667	6.687	0.704	7.827	1.000	0.554	0.574	0.618	0.613	.	5.560	5.560	7.840	1.083	0.676	1.000	1.000	0.991	890	Receptor,_ligand_binding_region	.	.	ID=COSV53601131;OCCURENCE=1(stomach)	GRIA1	36	0	108	6	0.0526315789473684	TRUE	NA
ENSG00000113327.16	.	BCM	GRCh38.p13	chr5	162153305	162153305	+	C	C	G	Missense_Mutation	SNP	ENST00000639213.1	exon9	c.C1341G	p.I447M	exonic	ENSG00000113327.16	.	nonsynonymous SNV	ENSG00000113327.16:ENST00000639213.1:exon9:c.C1341G:p.I447M	5q34	C3N-01168	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	L	D	N	0.611	D	D	D	0.652	0.594	0.912	1.429	D	T	D	D	D	D	2.958	23.300	0.997	D	D	0.471	4.818	0.465	4.858	0.000	0.554	0.574	0.618	0.564	.	5.950	5.090	0.051	1.008	0.599	0.902	1.000	0.994	964	Neurotransmitter-gated_ion-channel_transmembrane_domain	.	.	.	GABRG2	326	0	715	76	0.0960809102402023	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21974696	21974696	+	-	NA	T	Nonsense_Mutation	SNP	ENST00000304494.9	exon1	c.131dupA	p.Y44*	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon1:c.131dupA:p.Y44*	9p21.3	C3N-01168	8.457e-06	0	0	0	0	1.547e-05	0	0	rs730881673	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	NA	NA	NA	NA	NA	NA	NA
ENSG00000187908.19	.	BCM	GRCh38.p13	chr10	122631225	122631225	+	G	G	A	Missense_Mutation	SNP	ENST00000368909.7	exon46	c.G5903A	p.R1968Q	exonic	ENSG00000187908.19	.	nonsynonymous SNV	ENSG00000187908.19:ENST00000368909.7:exon46:c.G5903A:p.R1968Q	10q26.13	C3N-01168	0.0016	0	8.639e-05	0.0213	0	2.997e-05	0	0.0007	rs149958745	2.18	T	T	D	D	.	N	L	T	N	0.112	T	T	.	0.107	.	0.461	0.667	T	T	T	T	T	T	0.847	9.869	0.954	N	N	-0.903	0.516	-0.974	0.522	0.153	0.487	0.590	0.574	0.564	.	5.560	-1.870	-3.445	-0.666	-0.110	0.000	0.072	0.989	571	SRCR_domain;SRCR-like_domain	.	.	ID=COSV57556235;OCCURENCE=1(ovary),1(haematopoietic_and_lymphoid_tissue),1(skin)	DMBT1	187	0	404	31	0.071264367816092	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-01168	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	261	2	566	66	0.104430379746835	TRUE	TRUE
ENSG00000185974.7	.	BCM	GRCh38.p13	chr13	113671551	113671551	+	G	G	A	Missense_Mutation	SNP	ENST00000335678.7	exon3	c.G880A	p.A294T	exonic	ENSG00000185974.7	.	nonsynonymous SNV	ENSG00000185974.7:ENST00000335678.7:exon3:c.G880A:p.A294T	13q34	C3N-01168	3.336e-05	0	0	0	0	6.042e-05	0	0	rs200986774	10.19	D	T	D	D	D	D	.	T	D	0.542	T	T	D	0.430	.	0.893	0.280	T	T	T	T	D	D	2.824	23.100	0.997	D	N	0.212	3.355	0.079	2.652	1.000	0.581	0.574	0.576	0.564	.	4.430	4.430	3.426	1.086	0.638	0.694	0.002	0.003	970	Rhodopsin_kinase,_catalytic_domain;Protein_kinase_domain	.	.	ID=COSV59552488;OCCURENCE=2(large_intestine),1(lung),1(endometrium)	GRK1	255	0	705	61	0.0796344647519582	TRUE	TRUE
ENSG00000090060.18	.	BCM	GRCh38.p13	chr14	96536994	96536994	+	A	A	C	Missense_Mutation	SNP	ENST00000216277.12	exon12	c.A1049C	p.E350A	exonic	ENSG00000090060.18	.	nonsynonymous SNV	ENSG00000090060.18:ENST00000216277.12:exon12:c.A1049C:p.E350A	14q32.2	C3N-01168	.	.	.	.	.	.	.	.	.	12.19	D	D	P	P	D	D	L	.	D	0.888	T	T	D	0.465	0.575	0.874	2.059	T	T	D	D	D	D	4.402	31	0.994	D	D	0.621	6.145	0.637	6.720	1.000	0.732	0.725	0.710	0.728	.	5.010	5.010	9.271	1.312	0.756	1.000	1.000	1.000	963	Poly(A)_polymerase,_central_domain	.	.	.	PAPOLA	124	0	333	20	0.056657223796034	TRUE	TRUE
ENSG00000198826.11	.	BCM	GRCh38.p13	chr15	32636795	32636795	+	T	T	A	Missense_Mutation	SNP	ENST00000361627.8	exon12	c.T2022A	p.F674L	exonic	ENSG00000198826.11	.	nonsynonymous SNV	ENSG00000198826.11:ENST00000361627.8:exon12:c.T2022A:p.F674L	15q13.3	C3N-01168	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.064	T	T	T	0.021	0.316	0.230	0.035	T	T	T	T	T	T	0.368	5.074	0.717	N	N	-1.121	0.288	-1.136	0.340	1.000	0.707	0.602	0.609	0.714	.	4.910	-0.845	-0.158	-0.001	0.665	0.051	0.064	0.706	982	.	.	.	.	ARHGAP11A	87	0	207	16	0.0717488789237668	TRUE	TRUE
ENSG00000100726.15	.	BCM	GRCh38.p13	chr16	1500123	1500123	+	C	C	T	Missense_Mutation	SNP	ENST00000262319.11	exon7	c.C961T	p.H321Y	exonic	ENSG00000100726.15	.	nonsynonymous SNV	ENSG00000100726.15:ENST00000262319.11:exon7:c.C961T:p.H321Y	16p13.3	C3N-01168	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	D	N	0.263	T	T	D	0.165	0.553	0.518	0.138	T	T	T	T	T	T	1.361	14.820	0.683	N	N	-1.174	0.246	-0.858	0.677	0.092	0.707	0.702	0.723	0.714	.	4.860	2.600	2.461	-0.158	-0.754	1.000	0.987	0.868	769	.	.	.	.	TELO2	115	0	374	37	0.0900243309002433	TRUE	TRUE
ENSG00000167716.18	.	BCM	GRCh38.p13	chr17	1727940	1727940	+	G	G	C	Missense_Mutation	SNP	ENST00000409644.5	exon1	c.G2981C	p.R994P	exonic	ENSG00000167716.18	.	nonsynonymous SNV	ENSG00000167716.18:ENST00000409644.5:exon1:c.G2981C:p.R994P	17p13.3	C3N-01168	5.399e-05	0	0	0	0	0	0	0.0001	rs770995429	12.17	D	D	.	.	.	D	M	T	D	0.833	T	T	D	0.792	0.702	0.790	1.471	T	T	D	D	D	D	4.305	29.600	0.997	D	D	0.889	10.768	0.884	13.096	1.000	0.646	0.577	0.645	0.605	.	5.670	5.670	9.852	1.176	0.676	1.000	1.000	0.990	665	.	.	.	.	WDR81	209	0	522	74	0.124161073825503	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674935	7674935	+	C	C	-	Frame_Shift_Del	NA	ENST00000269305.8	exon6	c.596delG	p.G199Efs*48	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon6:c.596delG:p.G199Efs*48	17p13.1	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	509	0	819	111	0.119354838709677	TRUE	TRUE
ENSG00000108799.13	.	BCM	GRCh38.p13	chr17	42713329	42713329	+	G	G	A	Missense_Mutation	SNP	ENST00000428826.7	exon11	c.C1084T	p.R362W	exonic	ENSG00000108799.13	.	nonsynonymous SNV	ENSG00000108799.13:ENST00000428826.7:exon11:c.C1084T:p.R362W	17q21.2	C3N-01168	8.24e-06	0	0	0	0	1.499e-05	0	0	rs747924624	17.20	D	D	D	D	D	D	M	D	N	0.545	D	D	D	0.657	0.479	0.903	2.468	T	T	D	D	D	D	3.952	26.700	0.999	D	D	0.542	5.383	0.486	5.037	0.008	0.745	0.723	0.732	0.636	.	5.260	3.100	3.980	1.176	0.676	1.000	0.999	0.998	240	.	.	.	.	EZH1	108	0	321	21	0.0614035087719298	TRUE	NA
ENSG00000105202.9	.	BCM	GRCh38.p13	chr19	39837825	39837825	+	C	C	T	Missense_Mutation	SNP	ENST00000221801.8	exon6	c.G568A	p.V190I	exonic	ENSG00000105202.9	.	nonsynonymous SNV	ENSG00000105202.9:ENST00000221801.8:exon6:c.G568A:p.V190I	19q13.2	C3N-01168	.	.	.	.	.	.	.	.	.	7.18	T	T	P	P	D	D	M	.	N	0.698	T	T	T	0.455	0.814	0.448	1.171	T	T	D	T	D	.	4.052	27.400	0.999	D	D	0.753	7.931	0.740	8.570	1.000	0.707	0.725	0.725	0.714	.	5.350	5.350	7.560	1.026	0.599	1.000	0.999	0.991	610	Fibrillarin,_conserved_site	.	.	.	FBL	161	1	383	24	0.058968058968059	TRUE	TRUE
ENSG00000104972.15	.	BCM	GRCh38.p13	chr19	54632697	54632697	+	G	G	T	Missense_Mutation	SNP	ENST00000427581.6	exon5	c.G1003T	p.G335C	exonic	ENSG00000104972.15	.	nonsynonymous SNV	ENSG00000104972.15:ENST00000427581.6:exon5:c.G1003T:p.G335C	19q13.42	C3N-01168	.	.	.	.	.	.	.	.	.	6.19	D	D	D	D	N	N	.	T	D	0.537	T	T	T	0.097	0.771	0.419	0.376	T	T	T	T	D	T	1.944	18.830	0.994	N	N	-0.108	2.151	-0.465	1.260	0.822	0.722	0.699	0.574	0.564	.	2.030	0.954	0.042	0.714	-0.282	0.003	0.002	0.000	804	Immunoglobulin_subtype_2;Immunoglobulin_subtype	.	.	ID=COSV100207220;OCCURENCE=1(skin)	LILRB1	235	0	578	73	0.112135176651306	NA	TRUE
ENSG00000124203.6	.	BCM	GRCh38.p13	chr20	59191471	59191471	+	G	G	A	Missense_Mutation	SNP	ENST00000637017.1	exon4	c.G452A	p.R151H	exonic	ENSG00000124203.6	.	nonsynonymous SNV	ENSG00000124203.6:ENST00000637017.1:exon4:c.G452A:p.R151H	20q13.32	C3N-01168	.	.	.	.	.	.	.	.	.	10.19	D	D	P	P	.	D	M	T	D	0.623	T	T	D	0.295	0.573	0.573	0.890	T	T	T	T	D	D	3.913	26.400	0.999	D	D	0.454	4.699	0.509	5.242	1.000	0.554	0.588	0.578	0.613	.	5.410	5.410	8.030	1.176	0.676	1.000	0.897	0.910	993	Zinc_finger_C2H2-type	.	.	ID=COSV64040627;OCCURENCE=3(large_intestine),1(upper_aerodigestive_tract)	ZNF831	150	1	507	54	0.0962566844919786	TRUE	TRUE
ENSG00000186976.15	.	BCM	GRCh38.p13	chr22	43555011	43555011	+	C	C	T	Missense_Mutation	SNP	ENST00000262726.12	exon27	c.G3506A	p.R1169H	exonic	ENSG00000186976.15	.	nonsynonymous SNV	ENSG00000186976.15:ENST00000262726.12:exon27:c.G3506A:p.R1169H	22q13.2	C3N-01168	2.471e-05	0.0002	0	0	0	1.498e-05	0	0	rs149074808	1.20	T	D	B	B	N	N	L	T	N	0.362	T	T	T	0.050	.	0.136	0.098	T	T	T	T	T	T	1.582	16.260	0.989	N	N	-0.895	0.526	-0.964	0.535	0.000	0.554	0.547	0.602	0.564	.	4.880	-1.120	0.930	-0.714	-0.202	0.124	0.000	0.541	846	DJBP,_EF-hand_domain	.	.	.	EFCAB6	385	0	683	84	0.109517601043025	TRUE	NA
ENSG00000183304.10	.	BCM	GRCh38.p13	chrX	8793666	8793666	+	A	A	T	Missense_Mutation	SNP	ENST00000543214.1	exon8	c.T922A	p.L308I	exonic	ENSG00000183304.10	.	nonsynonymous SNV	ENSG00000183304.10:ENST00000543214.1:exon8:c.T922A:p.L308I	Xp22.31	C3N-01168	.	.	.	.	.	.	.	.	.	0.16	T	T	B	B	.	N	N	.	N	0.283	T	T	T	0.035	0.316	0.306	0.057	.	T	T	T	T	T	0.698	8.439	0.906	N	.	.	.	.	.	0.215	.	.	.	.	.	0.678	0.678	2.059	0.490	0.410	0.965	0.003	0.004	987	.	.	.	ID=COSV66813715;OCCURENCE=2(large_intestine)	FAM9A	179	0	440	42	0.0871369294605809	TRUE	TRUE
ENSG00000185915.5	.	BCM	GRCh38.p13	chrX	21656450	21656450	+	C	C	T	Missense_Mutation	SNP	ENST00000379499.3	exon1	c.G1339A	p.D447N	exonic	ENSG00000185915.5	.	nonsynonymous SNV	ENSG00000185915.5:ENST00000379499.3:exon1:c.G1339A:p.D447N	Xp22.12	C3N-01168	.	.	.	.	.	.	.	.	.	5.19	T	T	P	B	D	D	L	T	N	0.113	T	T	D	0.219	0.857	0.905	0.583	D	T	T	T	T	T	2.329	21.700	0.888	D	.	.	.	.	.	0.945	.	.	.	.	.	4.630	4.630	2.383	1.022	0.596	1.000	0.997	0.843	40	.	.	.	ID=COSV104689980;OCCURENCE=1(skin)	KLHL34	212	0	604	55	0.0834597875569044	TRUE	NA
ENSG00000165164.14	.	BCM	GRCh38.p13	chrX	36310843	36310843	+	G	G	T	Missense_Mutation	SNP	ENST00000378653.8	exon56	c.G8198T	p.W2733L	exonic	ENSG00000165164.14	.	nonsynonymous SNV	ENSG00000165164.14:ENST00000378653.8:exon56:c.G8198T:p.W2733L	Xp21.1	C3N-01168	.	.	.	.	.	.	.	.	.	4.10	.	D	.	.	.	N	.	.	.	0.550	T	T	D	0.366	.	0.192	.	.	.	T	T	D	T	3.656	25.200	0.986	D	.	.	.	.	.	0.934	.	.	.	.	.	5.290	5.290	6.745	1.005	0.671	1.000	0.906	0.728	778	.	.	.	.	CFAP47	138	0	287	23	0.0741935483870968	NA	TRUE
ENSG00000213401.10	.	BCM	GRCh38.p13	chrX	152736774	152736774	+	G	G	A	Missense_Mutation	SNP	ENST00000393869.8	exon3	c.G613A	p.V205I	exonic	ENSG00000213401.10	.	nonsynonymous SNV	ENSG00000213401.10:ENST00000393869.8:exon3:c.G613A:p.V205I	Xq28	C3N-01168	.	.	.	.	.	.	.	.	.	0.6	T	T	.	.	.	.	.	T	N	0.046	.	.	.	.	.	.	.	.	T	.	.	.	T	-0.688	0.046	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	-0.302	-3.950	-1.848	0.008	0.000	0.001	663	MAGE_homology_domain	.	.	ID=COSV63295359;OCCURENCE=1(large_intestine),1(stomach)	MAGEA12	573	0	1434	171	0.106542056074766	NA	TRUE
ENSG00000198753.12	.	BCM	GRCh38.p13	chrX	153778304	153778304	+	G	G	A	Missense_Mutation	SNP	ENST00000361971.10	exon33	c.G5453A	p.R1818H	exonic	ENSG00000198753.12	.	nonsynonymous SNV	ENSG00000198753.12:ENST00000361971.10:exon33:c.G5453A:p.R1818H	Xq28	C3N-01168	.	.	.	.	.	.	.	.	.	8.19	T	D	B	B	D	D	L	T	D	0.291	T	T	D	0.133	0.580	0.597	.	T	T	T	T	D	D	3.450	24.600	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.220	4.290	5.591	0.226	0.676	1.000	0.994	0.973	57	Plexin,_cytoplasmic_RasGAP_domain	.	.	.	PLXNB3	78	0	230	26	0.1015625	TRUE	NA
ENSG00000143450.17	.	BCM	GRCh38.p13	chr1	151767260	151767260	+	C	C	T	Silent	SNP	ENST00000400999.6	exon3	c.C264T	p.T88T	exonic	ENSG00000143450.17	.	synonymous SNV	ENSG00000143450.17:ENST00000400999.6:exon3:c.C264T:p.T88T	1q21.3	C3N-01168	8.297e-06	0	0	0	0	1.501e-05	0	0	rs539535190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58617590;OCCURENCE=3(prostate)	OAZ3	132	0	406	29	0.0666666666666667	TRUE	TRUE
ENSG00000058673.16	.	BCM	GRCh38.p13	chr1	203847281	203847281	+	C	C	T	Silent	SNP	ENST00000639812.1	exon13	c.C1140T	p.L380L	exonic	ENSG00000058673.16	.	synonymous SNV	ENSG00000058673.16:ENST00000639812.1:exon13:c.C1140T:p.L380L	1q32.1	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZC3H11A	349	0	929	162	0.148487626031164	NA	TRUE
ENSG00000272674.3	.	BCM	GRCh38.p13	chr5	141184224	141184224	+	C	C	T	Silent	SNP	ENST00000609684.2	exon1	c.C1665T	p.N555N	exonic	ENSG00000272674.3	.	synonymous SNV	ENSG00000272674.3:ENST00000609684.2:exon1:c.C1665T:p.N555N	5q31.3	C3N-01168	1.037e-05	0.0002	0	0	0	0	0	0	rs782078950	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53362553;OCCURENCE=2(endometrium)	PCDHB16	489	0	1133	134	0.105761641673244	NA	TRUE
ENSG00000165309.14	.	BCM	GRCh38.p13	chr10	22998280	22998280	+	G	G	A	Silent	SNP	ENST00000298032.10	exon11	c.G1308A	p.Q436Q	exonic	ENSG00000165309.14	.	synonymous SNV	ENSG00000165309.14:ENST00000298032.10:exon11:c.G1308A:p.Q436Q	10p12.2	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARMC3	495	0	955	94	0.0896091515729266	TRUE	TRUE
ENSG00000117983.17	.	BCM	GRCh38.p13	chr11	1249081	1249081	+	C	C	T	Silent	SNP	ENST00000529681.5	exon31	c.C12201T	p.S4067S	exonic	ENSG00000117983.17	.	synonymous SNV	ENSG00000117983.17:ENST00000529681.5:exon31:c.C12201T:p.S4067S	11p15.5	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC5B	627	0	1239	132	0.0962800875273523	NA	TRUE
ENSG00000123200.16	.	BCM	GRCh38.p13	chr13	46045487	46045487	+	C	C	T	Silent	SNP	ENST00000242848.8	exon2	c.G21A	p.K7K	exonic	ENSG00000123200.16	.	synonymous SNV	ENSG00000123200.16:ENST00000242848.8:exon2:c.G21A:p.K7K	13q14.13	C3N-01168	8.238e-06	0	0	0	0	1.499e-05	0	0	rs750929563	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZC3H13	161	0	358	45	0.11166253101737	TRUE	NA
ENSG00000090861.16	.	BCM	GRCh38.p13	chr16	70253322	70253322	+	G	G	A	Silent	SNP	ENST00000261772.13	exon20	c.C2667T	p.L889L	exonic	ENSG00000090861.16	.	synonymous SNV	ENSG00000090861.16:ENST00000261772.13:exon20:c.C2667T:p.L889L	16q22.1	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AARS1	483	0	1070	104	0.0885860306643952	TRUE	TRUE
ENSG00000108262.15	.	BCM	GRCh38.p13	chr17	29574813	29574813	+	G	G	A	Silent	SNP	ENST00000225394.7	exon20	c.C2175T	p.G725G	exonic	ENSG00000108262.15	.	synonymous SNV	ENSG00000108262.15:ENST00000225394.7:exon20:c.C2175T:p.G725G	17q11.2	C3N-01168	2.837e-05	0	0	0	0	0	0	0.0002	rs762322741	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GIT1	118	0	459	53	0.103515625	TRUE	NA
ENSG00000184640.18	.	BCM	GRCh38.p13	chr17	77482160	77482160	+	C	C	T	Silent	SNP	ENST00000427177.6	exon4	c.C738T	p.P246P	exonic	ENSG00000184640.18	.	synonymous SNV	ENSG00000184640.18:ENST00000427177.6:exon4:c.C738T:p.P246P	17q25.3	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEPTIN9	131	0	289	38	0.116207951070336	TRUE	NA
ENSG00000065717.15	.	BCM	GRCh38.p13	chr19	3006495	3006495	+	G	G	T	Silent	SNP	ENST00000262953.11	exon15	c.C1425A	p.G475G	exonic	ENSG00000065717.15	.	synonymous SNV	ENSG00000065717.15:ENST00000262953.11:exon15:c.C1425A:p.G475G	19p13.3	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TLE2	151	0	523	47	0.0824561403508772	TRUE	TRUE
ENSG00000007047.15	.	BCM	GRCh38.p13	chr19	45302701	45302701	+	C	C	T	Silent	SNP	ENST00000262891.9	exon17	c.C2250T	p.L750L	exonic	ENSG00000007047.15	.	synonymous SNV	ENSG00000007047.15:ENST00000262891.9:exon17:c.C2250T:p.L750L	19q13.32	C3N-01168	.	.	.	.	.	.	.	.	rs946478177	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MARK4	187	0	558	32	0.0542372881355932	TRUE	NA
ENSG00000068354.16	.	BCM	GRCh38.p13	chrX	48560567	48560567	+	C	C	T	Silent	SNP	ENST00000376771.9	exon6	c.C1659T	p.S553S	exonic	ENSG00000068354.16	.	synonymous SNV	ENSG00000068354.16:ENST00000376771.9:exon6:c.C1659T:p.S553S	Xp11.23	C3N-01168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBC1D25	98	0	238	14	0.0555555555555556	TRUE	TRUE
ENSG00000102081.15	.	BCM	GRCh38.p13	chrX	147944921	147944921	+	C	C	T	Silent	SNP	ENST00000370475.9	exon15	c.C1524T	p.D508D	exonic	ENSG00000102081.15	.	synonymous SNV	ENSG00000102081.15:ENST00000370475.9:exon15:c.C1524T:p.D508D	Xq27.3	C3N-01168	5.499e-05	0.0004	0	0	0	2.602e-05	0	0	rs376113075	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FMR1	177	1	363	34	0.0856423173803526	TRUE	NA
ENSG00000149091.15	.	BCM	GRCh38.p13	chr11	46366726	46366726	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000149091.15	.	.	.	11p11.2	C3N-01168	5.077e-05	0	0	0	0	0.0001	0	0	rs577494020	6.20	D	T	P	P	U	D	M	T	N	0.146	T	T	D	0.216	0.482	0.774	0.183	T	T	T	T	D	T	2.185	20.800	0.992	D	N	-0.230	1.793	-0.311	1.542	1.000	0.632	0.698	0.576	0.509	.	4.730	4.730	0.693	-0.138	-0.121	0.158	0.007	0.054	40	.	.	.	.	DGKZ	199	1	666	66	0.0901639344262295	TRUE	NA
ENSG00000188800.6	.	BCM	GRCh38.p13	chr1	40248076	40248076	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000372766.4	exon1	c.84dupT	p.L30Ffs*5	exonic	ENSG00000188800.6	.	frameshift insertion	ENSG00000188800.6:ENST00000372766.4:exon1:c.84dupT:p.L30Ffs*5	1p34.2	C3L-00622	8.237e-06	0	0	0	0	1.498e-05	0	0	rs761324353	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMCO2	NA	NA	NA	NA	NA	NA	NA
ENSG00000081985.12	.	BCM	GRCh38.p13	chr1	67367996	67367996	+	G	G	A	Missense_Mutation	SNP	ENST00000262345.5	exon10	c.G1430A	p.R477Q	exonic	ENSG00000081985.12	.	nonsynonymous SNV	ENSG00000081985.12:ENST00000262345.5:exon10:c.G1430A:p.R477Q	1p31.3	C3L-00622	.	.	.	.	.	.	.	.	.	1.20	T	D	B	B	N	N	N	T	N	0.077	T	T	T	0.107	0.475	0.566	0.159	T	T	T	T	T	T	1.523	15.890	0.992	N	N	-0.955	0.454	-0.893	0.630	1.000	0.638	0.670	0.659	0.688	.	5.020	5.020	0.380	0.128	-0.174	0.000	0.005	0.004	530	Fibronectin_type_III	.	.	.	IL12RB2	320	0	648	65	0.091164095371669	TRUE	NA
ENSG00000189334.9	.	BCM	GRCh38.p13	chr1	153614953	153614953	+	T	T	A	Missense_Mutation	SNP	ENST00000344616.4	exon4	c.A247T	p.S83C	exonic	ENSG00000189334.9	.	nonsynonymous SNV	ENSG00000189334.9:ENST00000344616.4:exon4:c.A247T:p.S83C	1q21.3	C3L-00622	.	.	.	.	.	.	.	.	.	4.20	D	D	P	B	N	N	L	T	D	0.309	T	T	T	0.140	0.584	0.313	0.096	T	T	T	T	D	T	3.108	23.600	0.991	N	N	-0.050	2.339	-0.074	2.124	1.000	0.615	0.610	0.659	0.613	.	4.860	4.860	2.046	1.120	0.641	0.822	0.934	0.976	238	.	.	.	.	S100A14	127	0	293	30	0.0928792569659443	TRUE	TRUE
ENSG00000117707.16	.	BCM	GRCh38.p13	chr1	213997034	213997034	+	G	G	A	Missense_Mutation	SNP	ENST00000366958.9	exon2	c.G499A	p.A167T	exonic	ENSG00000117707.16	.	nonsynonymous SNV	ENSG00000117707.16:ENST00000366958.9:exon2:c.G499A:p.A167T	1q32.3	C3L-00622	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	L	T	D	0.956	T	T	T	0.606	0.679	0.868	1.648	D	D	D	D	D	D	4.116	27.900	0.999	D	D	0.949	12.398	0.932	15.191	1.000	0.554	0.574	0.574	0.568	.	5.580	5.580	10.003	1.176	0.676	1.000	1.000	0.999	929	.	.	.	.	PROX1	114	0	259	29	0.100694444444444	TRUE	TRUE
ENSG00000143641.10	.	BCM	GRCh38.p13	chr1	230265357	230265357	+	G	G	A	Missense_Mutation	SNP	ENST00000366672.5	exon14	c.G1430A	p.G477E	exonic	ENSG00000143641.10	.	nonsynonymous SNV	ENSG00000143641.10:ENST00000366672.5:exon14:c.G1430A:p.G477E	1q42.13	C3L-00622	.	.	.	.	.	.	.	.	.	15.20	T	D	D	D	D	D	M	T	D	0.929	T	T	D	0.612	0.585	0.531	1.697	D	T	D	D	D	D	3.907	26.400	0.998	D	D	0.964	12.821	0.927	14.962	1.000	0.732	0.702	0.744	0.714	.	5.480	5.480	9.982	1.172	0.672	1.000	0.985	0.998	937	Ricin_B,_lectin_domain	.	.	.	GALNT2	111	0	235	31	0.116541353383459	TRUE	TRUE
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237454452	237454452	+	G	G	C	Missense_Mutation	SNP	ENST00000366574.7	exon15	c.G1354C	p.V452L	exonic	ENSG00000198626.17	.	nonsynonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon15:c.G1354C:p.V452L	1q43	C3L-00622	.	.	.	.	.	.	.	.	.	10.19	T	.	P	P	U	D	L	D	N	0.786	D	D	D	0.656	0.649	0.805	0.381	T	T	D	T	D	D	2.467	22.300	0.958	D	D	0.287	3.711	0.190	3.136	0.908	0.487	0.574	0.574	0.564	.	5.870	4.960	6.906	1.166	0.665	1.000	0.194	0.080	958	.	.	.	.	RYR2	126	0	280	29	0.0938511326860841	TRUE	TRUE
ENSG00000203663.4	.	BCM	GRCh38.p13	chr1	248038466	248038466	+	C	C	A	Missense_Mutation	SNP	ENST00000641771.1	exon3	c.C199A	p.L67I	exonic	ENSG00000203663.4	.	nonsynonymous SNV	ENSG00000203663.4:ENST00000641771.1:exon3:c.C199A:p.L67I	1q44	C3L-00622	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.061	T	T	T	0.012	0.379	0.055	0.016	T	T	T	T	T	T	-0.417	0.177	0.891	N	N	-1.236	0.203	-1.343	0.182	0.000	0.487	0.574	0.574	0.564	.	1.900	-0.289	-5.886	0.482	0.419	0.000	0.002	0.002	912	GPCR,_rhodopsin-like,_7TM	.	.	.	OR2L2	199	0	346	28	0.0748663101604278	NA	TRUE
ENSG00000130561.17	.	BCM	GRCh38.p13	chr2	233320698	233320698	+	C	C	T	Missense_Mutation	SNP	ENST00000409110.6	exon5	c.C250T	p.R84C	exonic	ENSG00000130561.17	.	nonsynonymous SNV	ENSG00000130561.17:ENST00000409110.6:exon5:c.C250T:p.R84C	2q37.1	C3L-00622	0.0021	0.0195	0.0020	0	0	0.0004	0.0019	0.0003	rs115857633	10.18	D	D	D	D	D	D	M	T	D	0.874	T	T	.	0.357	.	0.631	0.666	T	T	T	T	T	.	4.004	27.000	0.999	D	D	0.611	6.042	0.561	5.764	1.000	0.497	0.590	0.547	0.530	.	4.460	4.460	2.223	1.026	0.599	1.000	0.999	0.951	861	Arrestin,_conserved_site;Arrestin-like,_N-terminal	.	.	ID=COSV68592255;OCCURENCE=1(stomach)	SAG	287	0	515	36	0.0653357531760436	TRUE	TRUE
ENSG00000115694.15	.	BCM	GRCh38.p13	chr2	241499406	241499406	+	C	C	T	Missense_Mutation	SNP	ENST00000316586.9	exon6	c.G436A	p.V146M	exonic	ENSG00000115694.15	.	nonsynonymous SNV	ENSG00000115694.15:ENST00000316586.9:exon6:c.G436A:p.V146M	2q37.3	C3L-00622	.	.	.	.	.	.	.	.	rs1053183334	18.20	D	D	D	D	D	D	L	D	D	0.899	D	D	D	0.528	0.817	0.842	1.681	D	T	D	D	D	D	4.365	31	0.999	D	D	0.759	8.036	0.743	8.630	1.000	0.672	0.702	0.644	0.711	.	5.040	5.040	7.692	1.022	0.596	1.000	1.000	0.999	982	Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain;Serine/threonine_kinase_25,_catalytic_domain	.	.	.	STK25	105	0	270	29	0.096989966555184	TRUE	TRUE
ENSG00000163638.13	.	BCM	GRCh38.p13	chr3	64603928	64603928	+	C	C	A	Missense_Mutation	SNP	ENST00000498707.5	exon25	c.G3741T	p.W1247C	exonic	ENSG00000163638.13	.	nonsynonymous SNV	ENSG00000163638.13:ENST00000498707.5:exon25:c.G3741T:p.W1247C	3p14.1	C3L-00622	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.937	D	D	D	0.806	0.942	0.856	0.971	T	D	D	D	D	D	4.558	32	0.994	D	D	1.100	17.521	0.978	17.542	1.000	0.563	0.574	0.574	0.636	.	5.220	5.220	7.568	1.000	0.599	1.000	0.999	0.987	703	.	.	.	.	ADAMTS9	81	0	137	23	0.14375	TRUE	TRUE
ENSG00000114554.11	.	BCM	GRCh38.p13	chr3	127017752	127017752	+	C	C	T	Missense_Mutation	SNP	ENST00000393409.2	exon18	c.C3520T	p.R1174W	exonic	ENSG00000114554.11	.	nonsynonymous SNV	ENSG00000114554.11:ENST00000393409.2:exon18:c.C3520T:p.R1174W	3q21.3	C3L-00622	0.0001	0.0005	0	0.0007	0	3.043e-05	0	0.0002	rs371091022	15.20	D	D	D	D	N	D	M	T	D	0.843	T	D	D	0.597	.	0.685	1.293	D	D	T	D	T	D	3.975	26.800	0.999	D	D	0.574	5.671	0.490	5.073	1.000	0.707	0.654	0.723	0.714	.	4.250	4.250	3.092	0.980	0.549	1.000	0.916	0.409	936	IPT_domain	.	.	.	PLXNA1	109	0	333	31	0.0851648351648352	TRUE	NA
ENSG00000113205.5	.	BCM	GRCh38.p13	chr5	141102256	141102256	+	G	G	A	Missense_Mutation	SNP	ENST00000231130.3	exon1	c.G1607A	p.R536H	exonic	ENSG00000113205.5	.	nonsynonymous SNV	ENSG00000113205.5:ENST00000231130.3:exon1:c.G1607A:p.R536H	5q31.3	C3L-00622	.	.	.	.	.	.	.	.	.	1.14	T	T	.	.	.	N	.	T	D	0.092	T	T	T	0.026	0.451	0.158	.	T	.	T	T	T	T	1.578	16.230	0.921	N	.	-0.874	0.553	-0.873	0.656	0.000	0.554	0.574	0.618	0.621	.	4.140	3.140	-0.178	-0.184	0.570	0.000	0.002	0.018	491	.	.	.	ID=COSV50569302;OCCURENCE=4(large_intestine)	PCDHB3	837	0	1630	144	0.0811724915445321	NA	TRUE
ENSG00000227057.10	.	BCM	GRCh38.p13	chr6	33279819	33279819	+	G	G	A	Missense_Mutation	SNP	ENST00000374617.9	exon13	c.C1565T	p.A522V	exonic	ENSG00000227057.10	.	nonsynonymous SNV	ENSG00000227057.10:ENST00000374617.9:exon13:c.C1565T:p.A522V	6p21.32	C3L-00622	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	M	T	N	0.343	T	T	T	0.089	0.494	0.521	0.405	T	T	T	T	D	D	2.553	22.500	0.993	D	N	0.169	3.171	0.276	3.582	1.000	0.672	0.702	0.702	0.711	.	5.190	4.260	2.077	1.162	0.660	0.973	0.987	0.942	662	.	.	.	.	WDR46	131	0	234	25	0.0965250965250965	TRUE	TRUE
ENSG00000124507.11	.	BCM	GRCh38.p13	chr6	34530301	34530301	+	G	G	C	Missense_Mutation	SNP	ENST00000244458.7	exon7	c.G847C	p.D283H	exonic	ENSG00000124507.11	.	nonsynonymous SNV	ENSG00000124507.11:ENST00000244458.7:exon7:c.G847C:p.D283H	6p21.31	C3L-00622	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.980	D	T	D	0.673	0.469	0.795	1.490	D	D	D	D	D	D	4.338	29.900	0.996	D	D	0.930	11.850	0.841	11.458	1.000	0.706	0.588	0.710	0.542	.	4.510	4.510	9.915	1.083	0.676	1.000	0.998	0.989	632	F-BAR_domain	.	.	.	PACSIN1	79	0	264	26	0.0896551724137931	TRUE	TRUE
ENSG00000167910.4	.	BCM	GRCh38.p13	chr8	58491693	58491693	+	A	A	G	Missense_Mutation	SNP	ENST00000301645.4	exon6	c.T1297C	p.Y433H	exonic	ENSG00000167910.4	.	nonsynonymous SNV	ENSG00000167910.4:ENST00000301645.4:exon6:c.T1297C:p.Y433H	8q12.1	C3L-00622	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.185	T	T	D	0.529	0.759	0.891	0.534	T	D	T	T	D	T	3.719	25.500	0.998	D	D	0.432	4.546	0.425	4.537	1.000	0.487	0.574	0.574	0.542	.	5.870	4.720	7.508	0.325	-0.051	1.000	0.997	0.993	959	.	.	.	.	CYP7A1	210	0	443	33	0.069327731092437	TRUE	TRUE
ENSG00000197467.15	.	BCM	GRCh38.p13	chr10	69880518	69880518	+	G	G	A	Missense_Mutation	SNP	ENST00000398978.8	exon6	c.G451A	p.A151T	exonic	ENSG00000197467.15	.	nonsynonymous SNV	ENSG00000197467.15:ENST00000398978.8:exon6:c.G451A:p.A151T	10q22.1	C3L-00622	0.0071	0.0164	0.0029	0	0.0075	0.0091	0.0071	0.0004	rs144774788	8.19	T	T	D	D	D	D	L	D	N	0.434	D	D	.	0.308	.	0.877	0.130	T	T	T	T	T	T	3.165	23.800	0.998	D	N	0.464	4.771	0.503	5.190	1.000	0.706	0.590	0.468	0.613	.	5.420	5.420	3.335	1.176	0.676	1.000	0.974	0.866	554	.	.	.	ID=COSV62575253;OCCURENCE=1(pancreas)	COL13A1	147	0	233	21	0.0826771653543307	TRUE	TRUE
ENSG00000177363.5	.	BCM	GRCh38.p13	chr11	62687872	62687872	+	C	C	T	Missense_Mutation	SNP	ENST00000317449.5	exon2	c.G637A	p.A213T	exonic	ENSG00000177363.5	.	nonsynonymous SNV	ENSG00000177363.5:ENST00000317449.5:exon2:c.G637A:p.A213T	11q12.3	C3L-00622	.	.	.	.	.	.	.	.	.	5.19	T	T	D	P	U	D	L	.	N	0.165	T	T	D	0.154	0.355	0.497	0.439	T	T	T	T	D	T	2.906	23.200	0.999	D	N	0.335	3.964	0.345	3.991	1.000	0.680	0.547	0.601	0.555	.	5.350	5.350	1.712	1.025	0.598	0.918	0.541	0.848	439	.	.	.	ID=COSV54015532;OCCURENCE=1(large_intestine)	LRRN4CL	10	0	42	5	0.106382978723404	TRUE	TRUE
ENSG00000174669.12	.	BCM	GRCh38.p13	chr11	66365964	66365964	+	C	C	T	Missense_Mutation	SNP	ENST00000357440.7	exon10	c.G1031A	p.G344E	exonic	ENSG00000174669.12	.	nonsynonymous SNV	ENSG00000174669.12:ENST00000357440.7:exon10:c.G1031A:p.G344E	11q13.2	C3L-00622	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	H	D	D	0.994	D	D	D	0.910	0.963	0.751	0.649	T	D	D	D	D	D	3.913	26.400	0.997	D	D	0.693	7.027	0.623	6.529	1.000	0.632	0.694	0.698	0.655	.	5.550	4.640	7.761	0.947	0.599	1.000	0.998	0.996	61	.	.	.	.	SLC29A2	416	0	910	68	0.0695296523517382	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-00622	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	217	0	452	53	0.104950495049505	TRUE	TRUE
ENSG00000180998.12	.	BCM	GRCh38.p13	chr14	52553380	52553380	+	G	G	A	Missense_Mutation	SNP	ENST00000321662.11	exon1	c.G233A	p.R78Q	exonic	ENSG00000180998.12	.	nonsynonymous SNV	ENSG00000180998.12:ENST00000321662.11:exon1:c.G233A:p.R78Q	14q22.1	C3L-00622	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	N	D	M	T	D	0.640	T	T	D	0.297	0.484	0.326	1.624	D	T	T	T	D	D	4.543	32	0.998	D	D	0.531	5.288	0.467	4.871	1.000	0.564	0.552	0.520	0.492	.	4.720	4.720	7.932	1.176	0.616	1.000	1.000	0.979	777	.	.	.	.	GPR137C	190	0	479	50	0.0945179584120983	TRUE	TRUE
ENSG00000047578.13	.	BCM	GRCh38.p13	chr16	27677894	27677894	+	G	G	T	Missense_Mutation	SNP	ENST00000261588.9	exon7	c.G706T	p.D236Y	exonic	ENSG00000047578.13	.	nonsynonymous SNV	ENSG00000047578.13:ENST00000261588.9:exon7:c.G706T:p.D236Y	16p12.1	C3L-00622	.	.	.	.	.	.	.	.	.	2.20	T	T	D	P	N	N	M	T	N	0.425	T	T	T	0.061	0.190	0.322	0.679	T	T	T	T	T	T	1.941	18.800	0.934	N	N	-0.485	1.206	-0.655	0.965	0.999	0.615	0.634	0.659	0.662	.	5.480	1.180	0.418	0.203	-0.244	0.002	0.001	0.000	561	.	.	.	.	KIAA0556	317	0	621	65	0.0947521865889213	TRUE	TRUE
ENSG00000141503.17	.	BCM	GRCh38.p13	chr17	4895122	4895122	+	G	G	A	Missense_Mutation	SNP	ENST00000355280.11	exon25	c.G2965A	p.V989M	exonic	ENSG00000141503.17	.	nonsynonymous SNV	ENSG00000141503.17:ENST00000355280.11:exon25:c.G2965A:p.V989M	17p13.2	C3L-00622	7.485e-05	0.0001	0	0	0.0005	7.535e-05	0	0	rs200254448	9.20	D	T	D	P	D	D	M	T	N	0.509	T	T	D	0.213	.	0.630	0.515	T	T	T	T	T	D	3.921	26.500	0.999	D	D	0.693	7.020	0.700	7.756	1.000	0.672	0.702	0.702	0.711	.	5.300	5.300	5.310	1.176	0.676	1.000	0.995	0.997	260	.	.	.	.	MINK1	177	0	372	49	0.116389548693587	TRUE	NA
ENSG00000276231.5	.	BCM	GRCh38.p13	chr17	8829706	8829706	+	A	A	C	Missense_Mutation	SNP	ENST00000619866.5	exon10	c.T889G	p.W297G	exonic	ENSG00000276231.5	.	nonsynonymous SNV	ENSG00000276231.5:ENST00000619866.5:exon10:c.T889G:p.W297G	17p13.1	C3L-00622	.	.	.	.	.	.	.	.	.	8.11	.	D	D	D	.	.	.	.	.	0.841	.	.	D	.	.	0.530	.	T	T	D	D	.	T	3.920	26.500	0.924	D	D	.	.	.	.	1.000	0.284	0.279	0.084	0.042	.	4.730	4.730	3.463	1.312	0.756	1.000	0.995	0.954	911	.	.	.	.	PIK3R6	208	0	324	29	0.0821529745042493	TRUE	TRUE
ENSG00000215644.10	.	BCM	GRCh38.p13	chr17	81812901	81812901	+	C	C	T	Missense_Mutation	SNP	ENST00000400723.8	exon12	c.C1132T	p.R378C	exonic	ENSG00000215644.10	.	nonsynonymous SNV	ENSG00000215644.10:ENST00000400723.8:exon12:c.C1132T:p.R378C	17q25.3	C3L-00622	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	.	D	M	T	D	0.629	T	T	D	0.505	0.545	0.830	0.007	T	T	D	D	D	D	4.338	29.900	0.999	D	D	0.759	8.037	0.647	6.865	1.000	0.516	0.610	0.576	0.563	.	4.710	4.710	7.744	1.026	0.599	1.000	0.256	0.394	.	GPCR,_family_2-like	.	.	.	GCGR	155	0	449	39	0.0799180327868853	TRUE	NA
ENSG00000167658.16	.	BCM	GRCh38.p13	chr19	3983003	3983003	+	G	G	A	Missense_Mutation	SNP	ENST00000309311.7	exon4	c.C416T	p.T139M	exonic	ENSG00000167658.16	.	nonsynonymous SNV	ENSG00000167658.16:ENST00000309311.7:exon4:c.C416T:p.T139M	19p13.3	C3L-00622	.	.	.	.	.	.	.	.	.	17.20	D	D	P	P	D	D	H	T	D	0.975	D	D	D	0.873	0.931	0.976	.	D	D	D	D	D	D	4.085	27.600	0.998	D	D	0.578	5.706	0.432	4.593	1.000	0.731	0.672	0.750	0.639	.	5.150	4.110	9.845	1.176	0.676	1.000	0.763	0.685	804	Small_GTP-binding_protein_domain;Transcription_factor,_GTP-binding_domain	.	.	.	EEF2	219	1	523	46	0.0808435852372583	TRUE	TRUE
ENSG00000130377.13	.	BCM	GRCh38.p13	chr19	6183157	6183157	+	C	C	T	Nonsense_Mutation	SNP	ENST00000586696.5	exon10	c.C1207T	p.Q403X	exonic	ENSG00000130377.13	.	stopgain	ENSG00000130377.13:ENST00000586696.5:exon10:c.C1207T:p.Q403X	19p13.3	C3L-00622	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	A	.	.	.	0.096	.	.	.	.	.	.	.	.	.	D	D	.	.	5.853	35	0.921	N	N	-0.457	1.262	-0.836	0.707	0.000	0.554	0.588	0.316	0.530	.	5.040	-4.010	0.900	-0.730	-0.873	0.001	0.000	0.081	923	AMP-dependent_synthetase/ligase	.	.	.	ACSBG2	355	0	668	74	0.0997304582210243	TRUE	TRUE
ENSG00000126259.19	.	BCM	GRCh38.p13	chr19	35863034	35863034	+	C	C	T	Missense_Mutation	SNP	ENST00000360202.9	exon13	c.C1723T	p.R575W	exonic	ENSG00000126259.19	.	nonsynonymous SNV	ENSG00000126259.19:ENST00000360202.9:exon13:c.C1723T:p.R575W	19q13.12	C3L-00622	6.308e-05	0	0	0	0	0.0001	0	0	rs753993342	5.16	T	D	.	.	N	N	.	T	D	0.472	T	T	D	0.125	0.329	0.805	0.180	T	.	T	T	D	D	3.423	24.500	0.999	N	N	-0.183	1.925	-0.324	1.515	0.346	0.677	0.610	0.673	0.530	.	4.980	3.930	0.956	-0.291	0.599	0.007	0.495	0.313	851	.	.	.	.	KIRREL2	153	0	286	26	0.0833333333333333	TRUE	NA
ENSG00000170848.16	.	BCM	GRCh38.p13	chr19	42910822	42910822	+	A	A	G	Missense_Mutation	SNP	ENST00000292125.6	exon3	c.T464C	p.L155S	exonic	ENSG00000170848.16	.	nonsynonymous SNV	ENSG00000170848.16:ENST00000292125.6:exon3:c.T464C:p.L155S	19q13.31	C3L-00622	.	.	.	.	.	.	.	.	.	0.18	T	T	P	P	.	N	N	T	N	0.075	T	T	T	0.069	0.378	0.099	.	.	T	T	T	T	T	0.221	3.365	0.225	N	N	-1.488	0.085	-1.641	0.064	0.003	0.554	0.574	0.574	0.568	.	1.640	-3.280	-0.205	-0.197	0.252	0.000	0.001	0.038	712	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	PSG6	89	0	227	25	0.0992063492063492	NA	TRUE
ENSG00000026559.14	.	BCM	GRCh38.p13	chr20	51004310	51004310	+	G	G	A	Missense_Mutation	SNP	ENST00000371571.5	exon3	c.C1271T	p.T424M	exonic	ENSG00000026559.14	.	nonsynonymous SNV	ENSG00000026559.14:ENST00000371571.5:exon3:c.C1271T:p.T424M	20q13.13	C3L-00622	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.961	D	D	D	0.905	0.901	0.988	2.550	D	D	D	D	D	D	4.110	27.800	0.999	D	D	0.889	10.758	0.727	8.288	1.000	0.718	0.610	0.571	0.542	.	5.490	5.490	9.942	1.172	0.672	1.000	0.092	0.749	846	Ion_transport_domain	.	.	ID=COSV65367890;OCCURENCE=1(oesophagus),3(large_intestine),1(stomach),1(haematopoietic_and_lymphoid_tissue),1(endometrium)	KCNG1	131	0	290	28	0.0880503144654088	TRUE	TRUE
ENSG00000090432.7	.	BCM	GRCh38.p13	chr1	20501374	20501374	+	G	G	A	Silent	SNP	ENST00000264198.5	exon4	c.C375T	p.P125P	exonic	ENSG00000090432.7	.	synonymous SNV	ENSG00000090432.7:ENST00000264198.5:exon4:c.C375T:p.P125P	1p36.12	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUL1	99	0	158	17	0.0971428571428571	TRUE	TRUE
ENSG00000118960.13	.	BCM	GRCh38.p13	chr2	20638600	20638600	+	C	C	T	Silent	SNP	ENST00000304031.8	exon4	c.G459A	p.L153L	exonic	ENSG00000118960.13	.	synonymous SNV	ENSG00000118960.13:ENST00000304031.8:exon4:c.G459A:p.L153L	2p24.1	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HS1BP3	157	0	396	63	0.137254901960784	TRUE	TRUE
ENSG00000197415.12	.	BCM	GRCh38.p13	chr3	157363538	157363538	+	A	A	G	Silent	SNP	ENST00000362010.7	exon9	c.T1561C	p.L521L	exonic	ENSG00000197415.12	.	synonymous SNV	ENSG00000197415.12:ENST00000362010.7:exon9:c.T1561C:p.L521L	3q25.32	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VEPH1	137	1	302	41	0.119533527696793	TRUE	TRUE
ENSG00000138759.19	.	BCM	GRCh38.p13	chr4	78379790	78379790	+	G	G	A	Silent	SNP	ENST00000512123.4	exon27	c.G3357A	p.K1119K	exonic	ENSG00000138759.19	.	synonymous SNV	ENSG00000138759.19:ENST00000512123.4:exon27:c.G3357A:p.K1119K	4q21.21	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FRAS1	228	0	493	37	0.069811320754717	TRUE	TRUE
ENSG00000253910.2	.	BCM	GRCh38.p13	chr5	141360735	141360735	+	G	G	A	Silent	SNP	ENST00000522605.1	exon1	c.G600A	p.L200L	exonic	ENSG00000253910.2	.	synonymous SNV	ENSG00000253910.2:ENST00000522605.1:exon1:c.G600A:p.L200L	5q31.3	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHGB2	189	0	393	29	0.0687203791469194	TRUE	TRUE
ENSG00000012232.9	.	BCM	GRCh38.p13	chr8	28716092	28716092	+	C	C	T	Silent	SNP	ENST00000220562.9	exon3	c.C33T	p.G11G	exonic	ENSG00000012232.9	.	synonymous SNV	ENSG00000012232.9:ENST00000220562.9:exon3:c.C33T:p.G11G	8p21.1	C3L-00622	9.109e-05	9.664e-05	0.0008	0	0	1.506e-05	0	0	rs564285682	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55038472;OCCURENCE=1(large_intestine)	EXTL3	92	0	178	20	0.101010101010101	TRUE	TRUE
ENSG00000197416.4	.	BCM	GRCh38.p13	chr8	81531250	81531250	+	C	C	T	Silent	SNP	ENST00000360464.4	exon1	c.G66A	p.K22K	exonic	ENSG00000197416.4	.	synonymous SNV	ENSG00000197416.4:ENST00000360464.4:exon1:c.G66A:p.K22K	8q21.13	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FABP12	203	0	372	25	0.0629722921914358	TRUE	TRUE
ENSG00000022567.9	.	BCM	GRCh38.p13	chr8	141215807	141215807	+	G	G	A	Silent	SNP	ENST00000517878.5	exon6	c.C1893T	p.I631I	exonic	ENSG00000022567.9	.	synonymous SNV	ENSG00000022567.9:ENST00000517878.5:exon6:c.C1893T:p.I631I	8q24.3	C3L-00622	2.477e-05	0	0	0	0	4.511e-05	0	0	rs202082870	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC45A4	266	0	740	70	0.0864197530864197	TRUE	NA
ENSG00000182771.19	.	BCM	GRCh38.p13	chr10	86363957	86363957	+	G	G	A	Silent	SNP	ENST00000327946.12	exon2	c.C219T	p.F73F	exonic	ENSG00000182771.19	.	synonymous SNV	ENSG00000182771.19:ENST00000327946.12:exon2:c.C219T:p.F73F	10q23.2	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GRID1	111	0	176	28	0.137254901960784	TRUE	TRUE
ENSG00000148843.15	.	BCM	GRCh38.p13	chr10	103418562	103418562	+	G	G	A	Silent	SNP	ENST00000369797.8	exon15	c.G2034A	p.L678L	exonic	ENSG00000148843.15	.	synonymous SNV	ENSG00000148843.15:ENST00000369797.8:exon15:c.G2034A:p.L678L	10q24.33	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDCD11	175	0	388	32	0.0761904761904762	TRUE	TRUE
ENSG00000100523.16	.	BCM	GRCh38.p13	chr14	53054585	53054585	+	T	T	G	Silent	SNP	ENST00000673822.2	exon11	c.A2290C	p.R764R	exonic	ENSG00000100523.16	.	synonymous SNV	ENSG00000100523.16:ENST00000673822.2:exon11:c.A2290C:p.R764R	14q22.1	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DDHD1	98	0	206	29	0.123404255319149	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675994	7675994	+	C	C	T	Silent	SNP	ENST00000269305.8	exon4	c.G375A	p.T125T	exonic	ENSG00000141510.17	.	synonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon4:c.G375A:p.T125T	17p13.1	C3L-00622	.	.	.	.	.	.	.	.	rs55863639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52718605;OCCURENCE=2(oesophagus),1(meninges),9(large_intestine),5(central_nervous_system),2(biliary_tract),5(stomach),6(haematopoietic_and_lymphoid_tissue),1(kidney),1(urinary_tract),1(skin),2(prostate),2(lung),1(thyroid),5(upper_aerodigestive_tract)	TP53	165	0	302	20	0.062111801242236	TRUE	TRUE
ENSG00000160323.18	.	BCM	GRCh38.p13	chr9	133459230	133459230	+	C	C	G	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000160323.18	ENST00000371929.7:c.*50C>G	.	.	9q34.2	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAMTS13	400	0	947	94	0.090297790585975	TRUE	NA
ENSG00000141837.21	.	BCM	GRCh38.p13	chr19	13228757	13228757	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000141837.21	.	.	.	19p13.13	C3L-00622	.	.	.	.	.	.	.	.	.	6.13	.	T	.	.	.	D	.	T	.	.	T	T	D	0.251	0.395	0.751	.	.	T	T	T	D	D	1.960	18.950	0.982	D	D	0.449	4.663	0.380	4.222	1.000	0.646	0.685	0.645	0.563	.	4.040	2.980	7.804	1.026	0.547	1.000	1.000	0.998	851	Voltage-dependent_L-type_calcium_channel,_IQ-associated_domain	.	.	ID=COSV64214551;OCCURENCE=1(lung)	CACNA1A	104	0	176	14	0.0736842105263158	TRUE	TRUE
ENSG00000229807.12	.	BCM	GRCh38.p13	chrX	73825322	73825322	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000229807.12;ENSG00000270641.1	.	.	.	Xq13.2	C3L-00622	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	XIST	66	0	113	27	0.192857142857143	TRUE	NA
ENSG00000117143.13	.	BCM	GRCh38.p13	chr1	162566192	162566192	+	T	T	A	Missense_Mutation	SNP	ENST00000271469.7	exon2	c.T124A	p.F42I	exonic	ENSG00000117143.13	.	nonsynonymous SNV	ENSG00000117143.13:ENST00000271469.7:exon2:c.T124A:p.F42I	1q23.3	C3N-01381	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.638	T	T	T	0.062	0.323	0.249	1.060	T	T	T	T	D	D	2.420	22.200	0.965	D	D	-0.107	2.153	0.074	2.630	1.000	0.706	0.663	0.710	0.714	.	5.200	5.200	4.388	1.138	0.609	1.000	1.000	0.994	663	.	.	.	.	UAP1	362	3	533	70	0.116086235489221	TRUE	TRUE
ENSG00000143493.13	.	BCM	GRCh38.p13	chr1	211976618	211976618	+	C	C	T	Nonsense_Mutation	SNP	ENST00000366994.8	exon12	c.G1572A	p.W524X	exonic	ENSG00000143493.13	.	stopgain	ENSG00000143493.13:ENST00000366994.8:exon12:c.G1572A:p.W524X	1q32.3	C3N-01381	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.654	.	.	.	.	.	.	.	.	.	D	D	.	.	7.544	38	0.996	D	N	1.006	14.113	0.907	14.066	1.000	0.732	0.725	0.744	0.634	.	5.870	5.870	7.618	1.026	0.599	1.000	0.997	0.998	675	.	.	.	.	INTS7	184	0	276	30	0.0980392156862745	TRUE	TRUE
ENSG00000185013.16	.	BCM	GRCh38.p13	chr2	18587540	18587540	+	T	T	-	Frame_Shift_Del	NA	ENST00000359846.6	exon2	c.83delA	p.K28Rfs*10	exonic	ENSG00000185013.16;ENSG00000250741.6	.	frameshift deletion	ENSG00000185013.16:ENST00000359846.6:exon2:c.83delA:p.K28Rfs*10,ENSG00000250741.6:ENST00000532967.5:exon2:c.83delA:p.K28Rfs*10	2p24.2	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NT5C1B	249	1	310	22	0.0662650602409639	NA	TRUE
ENSG00000197410.14	.	BCM	GRCh38.p13	chr4	154234987	154234987	+	G	G	A	Missense_Mutation	SNP	ENST00000357232.10	exon20	c.C9665T	p.T3222M	exonic	ENSG00000197410.14	.	nonsynonymous SNV	ENSG00000197410.14:ENST00000357232.10:exon20:c.C9665T:p.T3222M	4q31.3	C3N-01381	3.3e-05	0	8.66e-05	0	0	4.499e-05	0	0	rs771060100	0.11	.	.	.	.	N	N	.	.	.	.	T	T	T	0.032	.	.	0.075	T	.	T	T	T	.	-0.193	0.528	0.951	N	N	-1.076	0.328	-1.093	0.383	0.001	0.487	0.574	0.547	0.564	.	5.940	-3.380	0.354	-0.898	-0.892	0.000	0.016	0.341	744	.	.	.	ID=COSV100600869;OCCURENCE=1(stomach),1(endometrium)	DCHS2	205	0	284	30	0.0955414012738854	TRUE	NA
ENSG00000001561.7	.	BCM	GRCh38.p13	chr6	46143576	46143576	+	C	C	T	Missense_Mutation	SNP	ENST00000321037.5	exon4	c.C1298T	p.S433F	exonic	ENSG00000001561.7	.	nonsynonymous SNV	ENSG00000001561.7:ENST00000321037.5:exon4:c.C1298T:p.S433F	6p21.1	C3N-01381	.	.	.	.	.	.	.	.	.	1.20	T	T	P	B	N	N	M	T	N	0.175	T	T	T	0.332	0.518	0.760	0.261	T	T	T	T	T	T	2.076	19.830	0.998	N	N	-0.071	2.268	-0.092	2.069	0.936	0.707	0.725	0.676	0.621	.	5.910	4.990	3.060	1.026	0.599	0.029	0.660	0.944	629	.	.	.	.	ENPP4	210	0	264	37	0.122923588039867	TRUE	TRUE
ENSG00000146373.16	.	BCM	GRCh38.p13	chr6	125045244	125045244	+	A	A	G	Missense_Mutation	SNP	ENST00000521654.6	exon2	c.A916G	p.I306V	exonic	ENSG00000146373.16	.	nonsynonymous SNV	ENSG00000146373.16:ENST00000521654.6:exon2:c.A916G:p.I306V	6q22.31	C3N-01381	.	.	.	.	.	.	.	.	.	4.18	T	T	.	.	N	D	N	T	N	0.293	T	T	T	0.078	-	0.477	1.001	T	T	T	T	D	T	2.074	19.820	0.938	D	D	0.114	2.944	0.256	3.469	1.000	0.651	0.588	0.653	0.684	.	6.170	5.020	6.731	0.324	0.756	1.000	0.991	0.986	892	.	.	.	.	RNF217	129	0	180	20	0.1	TRUE	TRUE
ENSG00000122641.11	.	BCM	GRCh38.p13	chr7	41690277	41690277	+	C	C	T	Nonsense_Mutation	SNP	ENST00000242208.5	exon3	c.G654A	p.W218X	exonic	ENSG00000122641.11	.	stopgain	ENSG00000122641.11:ENST00000242208.5:exon3:c.G654A:p.W218X	7p14.1	C3N-01381	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.856	.	.	.	.	.	.	.	.	.	D	D	.	.	7.527	38	0.998	D	N	1.030	14.892	0.938	15.481	1.000	0.707	0.588	0.608	0.714	.	6.060	6.060	7.844	0.947	0.599	1.000	0.996	0.979	861	TGF-beta,_propeptide	.	.	ID=COSV54219472;OCCURENCE=1(stomach),1(endometrium)	INHBA	286	0	456	52	0.102362204724409	TRUE	TRUE
ENSG00000188763.5	.	BCM	GRCh38.p13	chr7	73435515	73435515	+	C	C	T	Missense_Mutation	SNP	ENST00000344575.5	exon1	c.C1508T	p.S503L	exonic	ENSG00000188763.5	.	nonsynonymous SNV	ENSG00000188763.5:ENST00000344575.5:exon1:c.C1508T:p.S503L	7q11.23	C3N-01381	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	U	D	L	D	N	0.898	D	D	D	0.603	0.371	0.855	.	T	T	D	D	D	T	4.077	27.600	0.999	D	D	0.664	6.643	0.656	7.001	1.000	0.677	0.547	0.673	0.568	.	5.120	5.120	7.905	1.026	0.599	1.000	0.999	0.905	919	GPCR,_family_2-like;Frizzled/Smoothened,_transmembrane_domain	.	.	ID=COSV59989859;OCCURENCE=1(skin)	FZD9	196	0	466	48	0.0933852140077821	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971093	21971093	+	C	C	-	Frame_Shift_Del	NA	ENST00000304494.9	exon2	c.266delG	p.G89Afs*57	exonic	ENSG00000147889.17	.	frameshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.266delG:p.G89Afs*57	9p21.3	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	472	0	840	87	0.0938511326860841	NA	TRUE
ENSG00000196990.9	.	BCM	GRCh38.p13	chr9	133580141	133580141	+	C	C	T	Missense_Mutation	SNP	ENST00000673969.1	exon2	c.G83A	p.C28Y	exonic	ENSG00000196990.9	.	nonsynonymous SNV	ENSG00000196990.9:ENST00000673969.1:exon2:c.G83A:p.C28Y	9q34.2	C3N-01381	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	M	.	D	0.831	T	T	D	0.699	0.815	0.177	2.459	D	T	D	D	D	D	4.107	27.800	0.998	D	D	0.649	6.462	0.569	5.857	1.000	0.646	0.563	0.645	0.542	.	3.450	3.450	7.464	1.026	0.599	1.000	0.997	0.971	778	.	.	.	.	FAM163B	189	1	341	44	0.114285714285714	TRUE	TRUE
ENSG00000172572.6	.	BCM	GRCh38.p13	chr12	20630096	20630096	+	C	C	A	Missense_Mutation	SNP	ENST00000359062.3	exon6	c.C1729A	p.Q577K	exonic	ENSG00000172572.6	.	nonsynonymous SNV	ENSG00000172572.6:ENST00000359062.3:exon6:c.C1729A:p.Q577K	12p12.2	C3N-01381	.	.	.	.	.	.	.	.	.	4.20	D	T	B	B	N	N	M	T	N	0.406	T	T	T	0.130	0.283	0.646	0.089	T	T	T	T	D	T	2.155	20.500	0.980	D	N	-0.111	2.142	0.002	2.365	1.000	0.707	0.574	0.659	0.714	.	5.380	5.380	2.388	1.010	0.580	0.620	0.998	0.993	931	.	.	.	.	PDE3A	282	0	512	50	0.0889679715302491	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-01381	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	339	0	524	69	0.116357504215852	TRUE	TRUE
ENSG00000133116.8	.	BCM	GRCh38.p13	chr13	33061760	33061760	+	A	A	G	Missense_Mutation	SNP	ENST00000380099.4	exon4	c.A2681G	p.Y894C	exonic	ENSG00000133116.8	.	nonsynonymous SNV	ENSG00000133116.8:ENST00000380099.4:exon4:c.A2681G:p.Y894C	13q13.1	C3N-01381	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	H	T	D	0.954	T	T	D	0.682	0.698	0.821	0.644	T	T	D	D	D	D	3.330	24.200	0.997	D	.	0.751	7.893	0.573	5.902	1.000	0.554	0.588	0.547	0.613	.	5.560	5.560	7.269	1.312	0.756	1.000	0.183	0.689	542	.	.	.	.	KL	152	0	204	22	0.0973451327433628	TRUE	TRUE
ENSG00000070182.21	.	BCM	GRCh38.p13	chr14	64770945	64770945	+	C	C	T	Missense_Mutation	SNP	ENST00000389720.4	exon27	c.G5738A	p.R1913H	exonic	ENSG00000070182.21	.	nonsynonymous SNV	ENSG00000070182.21:ENST00000389720.4:exon27:c.G5738A:p.R1913H	14q23.3	C3N-01381	0.0003	0	0.0020	0	0	0.0002	0.0011	0	rs201489818	11.20	D	D	P	B	D	D	M	T	D	0.601	T	T	D	0.355	0.549	0.627	0.365	T	D	T	T	T	D	3.434	24.500	0.999	D	D	0.529	5.270	0.470	4.899	1.000	0.701	0.563	0.717	0.542	.	5.140	4.250	6.151	1.026	0.599	1.000	0.923	0.994	448	.	.	.	.	SPTB	450	0	960	89	0.0848427073403241	TRUE	NA
ENSG00000066933.16	.	BCM	GRCh38.p13	chr15	71898704	71898704	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000356056.10	exon25	c.3798dupA	p.V1267Sfs*5	exonic	ENSG00000066933.16	.	frameshift insertion	ENSG00000066933.16:ENST00000356056.10:exon25:c.3798dupA:p.V1267Sfs*5	15q23	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO9A	NA	NA	NA	NA	NA	NA	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674221	7674221	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.C742T	p.R248W	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.C742T:p.R248W	17p13.1	C3N-01381	8.24e-06	0	0	0	0	1.498e-05	0	0	rs121912651	19.20	D	D	D	D	D	A	M	D	D	0.991	D	D	D	0.927	0.986	0.984	0.393	T	D	D	D	D	D	4.158	28.300	0.999	D	D	0.506	5.084	0.371	4.161	0.000	0.722	0.702	0.725	0.735	.	4.620	2.560	0.835	1.157	0.672	1.000	0.987	0.874	433	p53,_DNA-binding_domain	.	.	ID=COSV52662035;OCCURENCE=1(salivary_gland),114(breast),1(penis),5(liver),2(genital_tract),65(oesophagus),1(cervix),238(large_intestine),62(central_nervous_system),12(biliary_tract),49(ovary),4(vulva),2(pleura),2(bone),9(NS),63(haematopoietic_and_lymphoid_tissue),52(stomach),14(kidney),11(soft_tissue),27(urinary_tract),40(pancreas),52(skin),14(prostate),47(lung),8(thyroid),51(upper_aerodigestive_tract),1(thymus),30(endometrium)	TP53	353	0	578	49	0.0781499202551834	TRUE	TRUE
ENSG00000109061.10	.	BCM	GRCh38.p13	chr17	10500728	10500728	+	C	C	T	Missense_Mutation	SNP	ENST00000226207.6	exon28	c.G3763A	p.A1255T	exonic	ENSG00000109061.10	.	nonsynonymous SNV	ENSG00000109061.10:ENST00000226207.6:exon28:c.G3763A:p.A1255T	17p13.1	C3N-01381	0.0002	9.61e-05	0	0	0	0.0003	0	0	rs142605633	2.20	T	T	B	B	N	N	N	D	N	0.033	T	T	D	0.143	.	0.451	0.088	T	T	T	T	T	T	-0.490	0.125	0.842	N	N	-1.320	0.154	-1.140	0.336	0.000	0.487	0.590	0.574	0.564	.	5.450	3.120	0.016	-0.172	-0.781	0.005	0.888	0.459	172	Myosin_tail	.	.	ID=COSV56846412;OCCURENCE=1(cervix),2(large_intestine),1(central_nervous_system),1(haematopoietic_and_lymphoid_tissue)	MYH1	273	0	379	59	0.134703196347032	TRUE	TRUE
ENSG00000154258.17	.	BCM	GRCh38.p13	chr17	68992230	68992230	+	G	G	A	Nonsense_Mutation	SNP	ENST00000340001.9	exon28	c.C3661T	p.R1221X	exonic	ENSG00000154258.17	.	stopgain	ENSG00000154258.17:ENST00000340001.9:exon28:c.C3661T:p.R1221X	17q24.2	C3N-01381	8.031e-05	0	0.0003	0	0	6.884e-05	0	7.476e-05	rs377378801	3.6	.	.	.	.	N	A	.	.	.	0.250	.	.	.	.	.	.	.	.	.	D	D	.	.	5.185	33	0.996	N	N	0.146	3.073	-0.083	2.096	0.001	0.651	0.588	0.547	0.684	.	5.260	4.290	0.518	-0.195	-1.091	0.028	0.015	0.216	976	.	.	.	.	ABCA9	86	0	121	10	0.0763358778625954	TRUE	NA
ENSG00000105707.14	.	BCM	GRCh38.p13	chr19	35060745	35060745	+	C	C	T	Missense_Mutation	SNP	ENST00000262626.6	exon9	c.C739T	p.R247W	exonic	ENSG00000105707.14	.	nonsynonymous SNV	ENSG00000105707.14:ENST00000262626.6:exon9:c.C739T:p.R247W	19q13.11	C3N-01381	2.504e-05	0.0002	0	0	0	0	0	6.443e-05	rs556783952	12.20	D	D	D	P	N	D	L	D	N	0.498	D	D	D	0.497	0.519	0.504	1.219	T	D	T	T	T	D	3.466	24.600	0.999	D	D	0.337	3.974	0.379	4.213	0.049	0.635	0.590	0.644	0.542	.	4.760	4.760	3.059	1.026	0.599	0.994	0.975	0.997	900	Serine_proteases,_trypsin_domain	.	.	ID=COSV52883028;OCCURENCE=3(large_intestine)	HPN	151	0	578	45	0.07223113964687	TRUE	TRUE
ENSG00000105221.18	.	BCM	GRCh38.p13	chr19	40236350	40236350	+	G	G	C	Missense_Mutation	SNP	ENST00000392038.7	exon10	c.C867G	p.I289M	exonic	ENSG00000105221.18	.	nonsynonymous SNV	ENSG00000105221.18:ENST00000392038.7:exon10:c.C867G:p.I289M	19q13.2	C3N-01381	.	.	.	.	.	.	.	.	.	13.20	D	D	P	P	D	D	M	T	D	0.829	T	T	D	0.393	0.761	0.727	1.833	D	D	T	T	D	D	3.435	24.500	0.996	D	D	0.269	3.623	0.263	3.508	0.656	0.737	0.702	0.733	0.714	.	5.690	4.650	0.455	1.172	0.672	0.999	1.000	1.000	867	Protein_kinase_domain;Protein_Kinase_B_beta,_catalytic_domain	.	.	ID=COSV60908462;OCCURENCE=3(breast)	AKT2	420	0	1278	70	0.0519287833827893	TRUE	TRUE
ENSG00000248385.8	.	BCM	GRCh38.p13	chr19	54074122	54074122	+	C	C	A	Missense_Mutation	SNP	ENST00000432826.2	exon4	c.G456T	p.L152F	exonic	ENSG00000248385.8	.	nonsynonymous SNV	ENSG00000248385.8:ENST00000432826.2:exon4:c.G456T:p.L152F	19q13.42	C3N-01381	.	.	.	.	.	.	.	.	.	0.15	T	T	.	.	.	N	.	T	N	0.132	T	T	T	0.023	.	0.014	.	T	.	T	T	T	T	-0.944	0.011	0.825	N	N	-1.924	0.013	-2.021	0.012	0.404	0.487	0.574	0.574	0.564	.	4.010	-8.020	-2.795	-1.138	-0.951	0.000	0.000	0.000	994	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	TARM1	399	0	709	128	0.152927120669056	TRUE	TRUE
ENSG00000149654.11	.	BCM	GRCh38.p13	chr20	46174853	46174853	+	A	A	C	Missense_Mutation	SNP	ENST00000537909.4	exon12	c.T2140G	p.S714A	exonic	ENSG00000149654.11	.	nonsynonymous SNV	ENSG00000149654.11:ENST00000537909.4:exon12:c.T2140G:p.S714A	20q13.12	C3N-01381	0	0	0	0	0	0	0	0	rs534273575	0.19	T	T	B	B	.	N	N	T	N	0.136	T	T	T	0.059	0.381	0.205	.	T	T	T	T	T	T	0.055	1.720	0.857	N	N	-1.348	0.140	-1.432	0.136	1.000	0.422	0.600	0.504	0.692	.	2.200	-3.310	-0.791	-0.883	-0.211	0.540	0.007	0.037	529	Cadherin,_cytoplasmic_domain	.	.	.	CDH22	55	1	179	12	0.06282722513089	TRUE	NA
ENSG00000026036.22	.	BCM	GRCh38.p13	chr20	63659478	63659478	+	A	A	G	Missense_Mutation	SNP	ENST00000492259.6	exon1	c.A76G	p.T26A	exonic	ENSG00000026036.22;ENSG00000258366.9	.	nonsynonymous SNV	ENSG00000026036.22:ENST00000492259.6:exon1:c.A76G:p.T26A,ENSG00000258366.9:ENST00000370018.7:exon2:c.A76G:p.T26A	20q13.33	C3N-01381	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.027	T	T	D	0.024	0.362	0.610	.	T	T	T	T	T	T	0.566	7.177	0.861	N	N	-1.134	0.277	-1.024	0.459	1.000	0.789	0.686	0.768	0.658	.	4.860	-1.590	-0.080	-0.060	-0.070	0.002	0.994	0.991	.	Helicase_superfamily_1/2,_ATP-binding_domain,_DinG/Rad3-type;Helicase-like,_DEXD_box_c2_type;Helicase/UvrB,_N-terminal	.	.	.	RTEL1-TNFRSF6B	280	0	466	41	0.0808678500986193	TRUE	TRUE
ENSG00000147274.14	.	BCM	GRCh38.p13	chrX	136879369	136879369	+	T	T	G	Missense_Mutation	SNP	ENST00000320676.11	exon2	c.A59C	p.N20T	exonic	ENSG00000147274.14	.	nonsynonymous SNV	ENSG00000147274.14:ENST00000320676.11:exon2:c.A59C:p.N20T	Xq26.3	C3N-01381	.	.	.	.	.	.	.	.	.	4.19	T	T	B	B	U	D	N	T	D	0.376	T	T	T	0.120	0.511	0.751	1.576	T	T	T	T	D	T	2.562	22.600	0.775	D	.	.	.	.	.	1.000	.	.	.	.	.	4.310	3.130	2.823	1.138	0.665	1.000	1.000	0.996	681	RNA_recognition_motif_domain;RNA_recognition_motif_domain,_eukaryote	.	.	.	RBMX	278	0	463	29	0.0589430894308943	TRUE	TRUE
ENSG00000159217.10	.	BCM	GRCh38.p13	chr17	49041501	49041501	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000159217.10	ENST00000290341.8:exon8:c.941+1G>A	.	.	17q21.32	C3N-01381	8.241e-06	0	0	0	0	1.5e-05	0	0	rs751435920	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.558	34	0.996	D	.	1.170	21.313	1.000	18.831	1.000	0.116	0.060	0.172	0.118	0.987	4.940	4.940	9.968	1.176	0.676	1.000	0.997	0.868	358	.	.	.	ID=COSV99288399;OCCURENCE=1(endometrium)	IGF2BP1	149	0	252	24	0.0869565217391304	TRUE	NA
ENSG00000198771.11	.	BCM	GRCh38.p13	chr1	167697647	167697647	+	G	G	A	Silent	SNP	ENST00000367854.8	exon6	c.G1023A	p.E341E	exonic	ENSG00000198771.11	.	synonymous SNV	ENSG00000198771.11:ENST00000367854.8:exon6:c.G1023A:p.E341E	1q24.2	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RCSD1	141	0	222	27	0.108433734939759	TRUE	TRUE
ENSG00000115806.13	.	BCM	GRCh38.p13	chr2	170950224	170950224	+	T	T	G	Silent	SNP	ENST00000234160.5	exon4	c.T369G	p.P123P	exonic	ENSG00000115806.13	.	synonymous SNV	ENSG00000115806.13:ENST00000234160.5:exon4:c.T369G:p.P123P	2q31.1	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GORASP2	245	0	286	34	0.10625	TRUE	TRUE
ENSG00000159069.14	.	BCM	GRCh38.p13	chr9	136942068	136942068	+	G	G	A	Silent	SNP	ENST00000325285.8	exon6	c.C1074T	p.L358L	exonic	ENSG00000159069.14	.	synonymous SNV	ENSG00000159069.14:ENST00000325285.8:exon6:c.C1074T:p.L358L	9q34.3	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBXW5	77	0	229	49	0.176258992805755	TRUE	NA
ENSG00000181090.21	.	BCM	GRCh38.p13	chr9	137716693	137716693	+	C	C	T	Silent	SNP	ENST00000460843.6	exon3	c.C153T	p.D51D	exonic	ENSG00000181090.21	.	synonymous SNV	ENSG00000181090.21:ENST00000460843.6:exon3:c.C153T:p.D51D	9q34.3	C3N-01381	5.896e-05	0	0.0003	0	0	4.595e-05	0	0	rs765396242	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EHMT1	113	0	152	13	0.0787878787878788	TRUE	NA
ENSG00000133083.14	.	BCM	GRCh38.p13	chr13	36126054	36126054	+	G	G	A	Silent	SNP	ENST00000360631.7	exon2	c.C84T	p.N28N	exonic	ENSG00000133083.14	.	synonymous SNV	ENSG00000133083.14:ENST00000360631.7:exon2:c.C84T:p.N28N	13q13.3	C3N-01381	.	.	.	.	.	.	.	.	rs373323934	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55173057;OCCURENCE=2(breast),1(liver),2(pancreas)	DCLK1	199	0	360	41	0.102244389027431	TRUE	TRUE
ENSG00000140955.11	.	BCM	GRCh38.p13	chr16	84195974	84195974	+	C	C	T	Silent	SNP	ENST00000315906.10	exon7	c.C1212T	p.A404A	exonic	ENSG00000140955.11	.	synonymous SNV	ENSG00000140955.11:ENST00000315906.10:exon7:c.C1212T:p.A404A	16q24.1	C3N-01381	0.3322	0.2018	0.5150	0.2657	0.3334	0.3258	0.3365	0.3402	rs2303239	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51892321;OCCURENCE=4(large_intestine),1(skin),3(lung),1(thyroid)	ADAD2	221	0	612	65	0.0960118168389956	TRUE	TRUE
ENSG00000101230.6	.	BCM	GRCh38.p13	chr20	13299372	13299372	+	C	C	A	Silent	SNP	ENST00000262487.5	exon6	c.C1308A	p.A436A	exonic	ENSG00000101230.6	.	synonymous SNV	ENSG00000101230.6:ENST00000262487.5:exon6:c.C1308A:p.A436A	20p12.1	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52604606;OCCURENCE=1(lung)	ISM1	136	0	262	29	0.0996563573883162	TRUE	TRUE
ENSG00000128573.26	.	BCM	GRCh38.p13	chr7	114690050	114690050	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000128573.26	ENST00000350908.9:c.*124C>T	.	.	7q31.1	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FOXP2	420	0	571	47	0.0760517799352751	TRUE	NA
ENSG00000166575.17	.	BCM	GRCh38.p13	chr11	87327537	87327537	+	G	G	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000166575.17	ENST00000305494.6:c.*6204G>T	.	.	11q14.2	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM135	112	0	221	24	0.0979591836734694	TRUE	NA
ENSG00000261879.7	.	BCM	GRCh38.p13	chr17	5214801	5214801	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000261879.7	.	.	.	17p13.2	C3N-01381	.	.	.	.	.	.	.	.	.	0.12	.	T	B	B	.	N	.	T	.	0.102	.	.	T	.	.	0.040	.	.	T	T	T	.	T	-0.274	0.353	0.124	N	N	.	.	.	.	0.001	0.563	0.654	0.547	0.613	.	0.149	-0.298	-2.163	-2.086	-2.459	0.001	0.001	0.001	488	.	.	.	.	AC087500.1	24	0	41	3	0.0681818181818182	TRUE	NA
ENSG00000131943.18	.	BCM	GRCh38.p13	chr19	29701504	29701504	+	A	A	G	3'Flank	SNP	NA	NA	NA	NA	downstream	ENSG00000131943.18	dist=899	.	.	19q12	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C19orf12	565	1	831	345	0.293367346938776	TRUE	NA
ENSG00000102145.15	.	BCM	GRCh38.p13	chrX	48791186	48791187	+	CC	CC	AT	Unknown	MNP	ENST00000376670.9	exon2	c.77_78delinsAT	p.S26Y	exonic	ENSG00000102145.15	.	nonframeshift substitution	ENSG00000102145.15:ENST00000376670.9:exon2:c.77_78delinsAT:p.S26Y	Xp11.23	C3N-01381	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GATA1	318	1	651	22	0.0326894502228826	TRUE	NA
ENSG00000180758.12	.	BCM	GRCh38.p13	chr1	9104552	9104552	+	G	G	C	Missense_Mutation	SNP	ENST00000377411.5	exon4	c.C875G	p.S292C	exonic	ENSG00000180758.12	.	nonsynonymous SNV	ENSG00000180758.12:ENST00000377411.5:exon4:c.C875G:p.S292C	1p36.22	C3L-01703	.	.	.	.	.	.	.	.	.	8.20	D	D	P	P	D	D	M	T	N	0.296	T	T	T	0.147	.	0.151	0.310	T	T	T	T	D	T	3.162	23.800	0.984	D	D	0.104	2.901	0.056	2.562	1.000	0.707	0.725	0.609	0.655	.	4.970	4.970	6.850	1.172	0.672	0.995	0.118	0.121	850	.	.	.	.	GPR157	247	0	299	41	0.120588235294118	TRUE	TRUE
ENSG00000177272.9	.	BCM	GRCh38.p13	chr1	110673711	110673711	+	G	G	A	Missense_Mutation	SNP	ENST00000369769.4	exon1	c.C1099T	p.R367C	exonic	ENSG00000177272.9	.	nonsynonymous SNV	ENSG00000177272.9:ENST00000369769.4:exon1:c.C1099T:p.R367C	1p13.3	C3L-01703	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	U	D	H	D	D	0.892	D	D	D	0.874	0.881	0.966	.	D	D	D	D	D	D	4.560	32	0.999	D	D	1.004	14.060	0.875	12.713	1.000	0.677	0.609	0.673	0.530	.	5.470	5.470	2.971	1.176	0.676	1.000	1.000	1.000	872	Ion_transport_domain	.	.	ID=COSV63901810;OCCURENCE=2(large_intestine)	KCNA3	343	1	468	74	0.136531365313653	TRUE	TRUE
ENSG00000162843.17	.	BCM	GRCh38.p13	chr1	241683566	241683566	+	G	G	A	Missense_Mutation	SNP	ENST00000366552.6	exon6	c.G674A	p.R225Q	exonic	ENSG00000162843.17	.	nonsynonymous SNV	ENSG00000162843.17:ENST00000366552.6:exon6:c.G674A:p.R225Q	1q43	C3L-01703	.	.	.	.	.	.	.	.	rs181076489	2.18	T	D	.	.	N	N	M	T	N	0.085	T	T	T	0.030	.	0.124	0.115	T	T	T	T	T	T	2.215	21.000	0.999	N	N	-0.174	1.949	-0.194	1.801	0.025	0.487	0.574	0.574	0.564	.	5.210	3.340	1.116	0.223	-0.167	0.003	0.720	0.657	857	.	.	.	.	WDR64	362	1	463	51	0.0992217898832685	TRUE	NA
ENSG00000144285.21	.	BCM	GRCh38.p13	chr2	166045101	166045101	+	C	C	T	Missense_Mutation	SNP	ENST00000303395.8	exon12	c.G1604A	p.R535H	exonic	ENSG00000144285.21	.	nonsynonymous SNV	ENSG00000144285.21:ENST00000303395.8:exon12:c.G1604A:p.R535H	2q24.3	C3L-01703	8.239e-06	0	8.64e-05	0	0	0	0	0	rs184524479	8.20	T	T	B	B	D	D	L	T	D	0.549	T	T	D	0.174	.	0.643	0.856	T	D	T	T	D	D	2.126	20.300	0.966	D	N	-0.193	1.896	-0.005	2.343	0.001	0.560	0.574	0.527	0.564	.	6.170	4.330	2.479	1.026	0.599	1.000	1.000	0.998	516	Voltage-gated_Na+_ion_channel,_cytoplasmic_domain	.	.	ID=COSV57677537;OCCURENCE=1(stomach)	SCN1A	359	0	436	70	0.138339920948617	TRUE	TRUE
ENSG00000163092.21	.	BCM	GRCh38.p13	chr2	167244420	167244420	+	G	G	A	Missense_Mutation	SNP	ENST00000628543.2	exon7	c.G2503A	p.V835I	exonic	ENSG00000163092.21	.	nonsynonymous SNV	ENSG00000163092.21:ENST00000628543.2:exon7:c.G2503A:p.V835I	2q24.3	C3L-01703	0.0001	0.0002	0	0.0001	0	0.0002	0	0.0002	rs369068245	1.19	T	.	B	B	N	D	N	T	N	0.090	T	T	T	0.023	.	0.014	0.019	T	T	T	T	T	T	-1.511	0.001	0.613	N	N	-1.759	0.028	-1.686	0.054	0.202	0.487	0.574	0.574	0.564	.	6.080	-2.560	-0.118	-2.404	-3.653	0.041	0.645	0.377	652	.	.	.	.	XIRP2	303	0	344	40	0.104166666666667	TRUE	NA
ENSG00000178568.15	.	BCM	GRCh38.p13	chr2	211704182	211704182	+	A	A	G	Missense_Mutation	SNP	ENST00000342788.9	exon11	c.T1211C	p.I404T	exonic	ENSG00000178568.15	.	nonsynonymous SNV	ENSG00000178568.15:ENST00000342788.9:exon11:c.T1211C:p.I404T	2q34	C3L-01703	.	.	.	.	.	.	.	.	.	18.20	D	D	P	D	D	D	H	T	D	0.870	D	D	D	0.699	0.883	0.847	1.101	D	D	D	D	D	D	4.055	27.400	0.997	D	D	0.688	6.958	0.712	7.976	1.000	0.554	0.574	0.602	0.632	.	6.020	6.020	9.325	1.312	0.756	1.000	0.998	0.964	817	Receptor_L-domain	.	.	.	ERBB4	413	0	536	56	0.0945945945945946	TRUE	TRUE
ENSG00000163513.19	.	BCM	GRCh38.p13	chr3	30674109	30674109	+	G	G	A	Missense_Mutation	SNP	ENST00000295754.10	exon5	c.G1259A	p.G420E	exonic	ENSG00000163513.19	.	nonsynonymous SNV	ENSG00000163513.19:ENST00000295754.10:exon5:c.G1259A:p.G420E	3p24.1	C3L-01703	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.995	D	D	D	0.801	0.942	0.960	1.685	D	D	D	D	D	D	4.276	29.400	0.998	D	D	1.106	17.773	1.052	22.444	1.000	0.722	0.590	0.609	0.735	.	5.980	5.980	10.003	1.176	0.674	1.000	1.000	0.993	925	Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	TGFBR2	542	0	633	74	0.104667609618105	TRUE	TRUE
ENSG00000182606.16	.	BCM	GRCh38.p13	chr3	42223298	42223298	+	A	A	G	Missense_Mutation	SNP	ENST00000327628.10	exon16	c.A2423G	p.N808S	exonic	ENSG00000182606.16	.	nonsynonymous SNV	ENSG00000182606.16:ENST00000327628.10:exon16:c.A2423G:p.N808S	3p22.1	C3L-01703	.	.	.	.	.	.	.	.	.	6.20	T	D	B	B	D	D	M	T	N	0.388	T	T	T	0.049	0.102	0.667	0.337	T	T	T	T	T	D	1.641	16.640	0.992	D	N	-0.288	1.644	-0.194	1.799	0.989	0.732	0.702	0.744	0.714	.	5.320	1.170	0.897	0.269	0.691	0.999	0.993	0.990	667	.	.	.	.	TRAK1	263	0	350	52	0.129353233830846	TRUE	TRUE
ENSG00000168268.11	.	BCM	GRCh38.p13	chr3	52528670	52528670	+	G	G	A	Missense_Mutation	SNP	ENST00000307076.8	exon4	c.C404T	p.A135V	exonic	ENSG00000168268.11	.	nonsynonymous SNV	ENSG00000168268.11:ENST00000307076.8:exon4:c.C404T:p.A135V	3p21.1	C3L-01703	.	.	.	.	.	.	.	.	.	12.20	D	T	P	P	D	D	M	T	D	0.848	T	T	D	0.529	0.760	0.477	1.109	T	T	D	D	D	D	3.997	27.000	0.999	D	D	0.630	6.241	0.530	5.445	1.000	0.672	0.702	0.702	0.711	.	4.480	4.480	7.771	1.176	0.618	1.000	0.999	0.996	97	.	.	.	ID=COSV58739494;OCCURENCE=1(skin)	NT5DC2	162	0	266	34	0.113333333333333	TRUE	TRUE
ENSG00000163931.16	.	BCM	GRCh38.p13	chr3	53228344	53228344	+	G	G	A	Missense_Mutation	SNP	ENST00000462138.6	exon11	c.C1411T	p.R471W	exonic	ENSG00000163931.16	.	nonsynonymous SNV	ENSG00000163931.16:ENST00000462138.6:exon11:c.C1411T:p.R471W	3p21.1	C3L-01703	8.249e-06	0	0	0.0001	0	0	0	0	rs201786364	19.20	D	D	D	D	D	D	H	D	D	0.940	D	D	D	0.814	.	0.987	1.190	T	D	D	D	D	D	4.633	32	0.999	D	D	0.917	11.490	0.801	10.161	1.000	0.672	0.702	0.702	0.711	.	5.520	4.570	3.335	1.176	0.676	1.000	1.000	0.995	462	Transketolase-like,_pyrimidine-binding_domain	.	.	.	TKT	376	0	447	70	0.135396518375242	TRUE	NA
ENSG00000016391.11	.	BCM	GRCh38.p13	chr3	53820543	53820543	+	T	T	A	Missense_Mutation	SNP	ENST00000315251.11	exon6	c.A1051T	p.T351S	exonic	ENSG00000016391.11	.	nonsynonymous SNV	ENSG00000016391.11:ENST00000315251.11:exon6:c.A1051T:p.T351S	3p21.1	C3L-01703	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	L	T	D	0.759	T	T	T	0.198	0.387	0.469	0.529	T	D	T	T	D	D	2.554	22.500	0.977	D	D	0.068	2.763	0.233	3.350	1.000	0.732	0.709	0.744	0.564	.	5.350	5.350	7.457	1.138	0.665	1.000	0.971	0.955	562	.	.	.	.	CHDH	231	0	264	27	0.0927835051546392	TRUE	TRUE
ENSG00000161202.20	.	BCM	GRCh38.p13	chr3	184166236	184166236	+	C	C	T	Missense_Mutation	SNP	ENST00000313143.9	exon8	c.C874T	p.R292C	exonic	ENSG00000161202.20	.	nonsynonymous SNV	ENSG00000161202.20:ENST00000313143.9:exon8:c.C874T:p.R292C	3q27.1	C3L-01703	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.890	T	T	D	0.462	0.788	0.816	2.008	D	D	D	D	D	D	4.187	28.500	0.999	D	D	0.872	10.340	0.804	10.238	1.000	0.707	0.725	0.725	0.714	.	5.800	5.800	2.466	1.026	0.599	0.985	1.000	0.996	862	PDZ_domain	.	.	ID=COSV57457221;OCCURENCE=1(small_intestine)	DVL3	200	0	276	40	0.126582278481013	TRUE	TRUE
ENSG00000164031.17	.	BCM	GRCh38.p13	chr4	99946565	99946565	+	C	C	T	Missense_Mutation	SNP	ENST00000442697.7	exon1	c.G7A	p.G3R	exonic	ENSG00000164031.17	.	nonsynonymous SNV	ENSG00000164031.17:ENST00000442697.7:exon1:c.G7A:p.G3R	4q23	C3L-01703	.	.	.	.	.	.	.	.	.	9.20	T	T	P	P	D	D	M	T	D	0.589	T	T	D	0.254	0.239	0.640	1.594	D	T	D	T	D	D	3.154	23.800	0.999	N	N	0.536	5.328	0.454	4.768	1.000	0.267	0.093	0.520	0.373	.	4.110	4.110	2.303	1.019	0.530	1.000	0.997	0.888	768	.	.	.	.	DNAJB14	286	2	491	77	0.13556338028169	NA	TRUE
ENSG00000212122.4	.	BCM	GRCh38.p13	chr5	113434127	113434127	+	G	G	A	Missense_Mutation	SNP	ENST00000390666.4	exon1	c.C713T	p.S238F	exonic	ENSG00000212122.4	.	nonsynonymous SNV	ENSG00000212122.4:ENST00000390666.4:exon1:c.C713T:p.S238F	5q22.2	C3L-01703	.	.	.	.	.	.	.	.	.	5.20	D	D	D	P	U	N	L	T	D	0.240	T	T	T	0.028	0.530	0.323	0.119	T	T	T	T	D	T	2.145	20.400	0.994	N	N	-0.381	1.425	-0.637	0.991	0.003	0.516	0.547	0.573	0.586	.	0.900	0.900	2.317	0.447	0.373	0.266	0.840	0.700	922	Protein_kinase_domain	.	.	.	TSSK1B	238	0	419	53	0.11228813559322	TRUE	TRUE
ENSG00000164244.21	.	BCM	GRCh38.p13	chr5	127533652	127533652	+	A	A	G	Missense_Mutation	SNP	ENST00000296666.13	exon6	c.A787G	p.T263A	exonic	ENSG00000164244.21	.	nonsynonymous SNV	ENSG00000164244.21:ENST00000296666.13:exon6:c.A787G:p.T263A	5q23.2	C3L-01703	.	.	.	.	.	.	.	.	.	5.19	T	T	B	B	D	D	L	.	N	0.896	T	T	T	0.119	0.332	0.452	0.134	T	T	T	T	T	D	2.377	22.000	0.865	D	D	-0.333	1.534	-0.158	1.889	0.998	0.707	0.725	0.725	0.714	.	5.240	4.070	6.671	1.312	0.756	1.000	0.994	0.974	492	.	.	.	.	PRRC1	221	0	276	23	0.0769230769230769	TRUE	TRUE
ENSG00000204252.14	.	BCM	GRCh38.p13	chr6	33008031	33008031	+	G	G	A	Missense_Mutation	SNP	ENST00000229829.7	exon2	c.C313T	p.R105C	exonic	ENSG00000204252.14	.	nonsynonymous SNV	ENSG00000204252.14:ENST00000229829.7:exon2:c.C313T:p.R105C	6p21.32	C3L-01703	0.0124	0.0025	0.0045	0.0014	0.0050	0.0136	0.0104	0.0283	rs11575906	3.18	T	T	D	P	N	D	L	T	D	0.156	T	T	.	0.105	.	.	1.018	T	T	T	T	T	.	2.877	23.200	0.992	N	N	-0.056	2.319	-0.187	1.817	0.997	0.745	0.686	0.732	0.542	.	4.110	0.979	0.292	1.176	0.674	0.166	0.969	0.703	895	MHC_class_II,_alpha_chain,_N-terminal	.	.	ID=COSV57713941;OCCURENCE=1(large_intestine),2(kidney),2(lung)	HLA-DOA	125	0	219	33	0.130952380952381	TRUE	TRUE
ENSG00000124721.18	.	BCM	GRCh38.p13	chr6	38894759	38894759	+	C	C	A	Missense_Mutation	SNP	ENST00000359357.7	exon57	c.C7991A	p.S2664Y	exonic	ENSG00000124721.18	.	nonsynonymous SNV	ENSG00000124721.18:ENST00000359357.7:exon57:c.C7991A:p.S2664Y	6p21.2	C3L-01703	.	.	.	.	.	.	.	.	.	15.19	D	.	D	D	N	D	H	T	D	0.977	D	T	D	0.449	0.645	0.756	0.654	D	T	D	D	D	D	3.813	25.900	0.996	D	D	1.013	14.349	0.885	13.144	0.095	0.516	0.590	0.547	0.586	.	5.330	5.330	4.806	1.026	0.599	1.000	1.000	1.000	553	.	.	.	.	DNAH8	295	0	411	39	0.0866666666666667	TRUE	TRUE
ENSG00000164597.13	.	BCM	GRCh38.p13	chr7	107248475	107248475	+	C	C	A	Missense_Mutation	SNP	ENST00000347053.7	exon16	c.G1804T	p.A602S	exonic	ENSG00000164597.13	.	nonsynonymous SNV	ENSG00000164597.13:ENST00000347053.7:exon16:c.G1804T:p.A602S	7q22.3	C3L-01703	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.452	T	T	T	0.087	0.483	0.545	0.056	T	T	T	T	D	D	2.153	20.500	0.985	D	D	0.004	2.526	0.215	3.258	1.000	0.706	0.659	0.710	0.613	.	5.830	5.830	5.133	1.025	0.599	1.000	0.998	0.996	396	.	.	.	.	COG5	339	1	505	51	0.091726618705036	TRUE	TRUE
ENSG00000257743.8	.	BCM	GRCh38.p13	chr7	142219897	142219897	+	A	A	G	Missense_Mutation	SNP	ENST00000477922.3	exon48	c.A5386G	p.T1796A	exonic	ENSG00000257743.8	.	nonsynonymous SNV	ENSG00000257743.8:ENST00000477922.3:exon48:c.A5386G:p.T1796A	7q34	C3L-01703	.	.	.	.	.	.	.	.	.	0.10	.	T	.	.	.	.	.	.	.	0.028	T	T	T	0.087	.	0.030	.	.	T	T	T	T	.	0.534	6.859	0.896	N	N	-0.494	1.188	-0.629	1.003	0.000	0.487	0.574	0.547	0.564	.	3.830	1.400	1.928	1.185	0.665	0.846	0.047	0.020	934	.	.	.	.	MGAM2	152	0	199	20	0.091324200913242	TRUE	TRUE
ENSG00000275342.5	.	BCM	GRCh38.p13	chr8	8376818	8376818	+	G	G	A	Missense_Mutation	SNP	ENST00000615670.5	exon3	c.C1591T	p.H531Y	exonic	ENSG00000275342.5	.	nonsynonymous SNV	ENSG00000275342.5:ENST00000615670.5:exon3:c.C1591T:p.H531Y	8p23.1	C3L-01703	.	.	.	.	.	.	.	.	.	1.14	.	T	.	.	N	N	.	.	.	0.234	T	T	T	0.094	.	0.072	.	T	T	T	T	D	T	1.824	17.910	0.585	N	N	-0.321	1.564	-0.404	1.365	1.000	0.722	0.699	0.702	0.711	.	4.890	4.000	0.655	1.176	0.676	0.000	0.004	0.010	926	.	.	.	.	PRAG1	131	0	212	40	0.158730158730159	TRUE	TRUE
ENSG00000275342.5	.	BCM	GRCh38.p13	chr8	8376835	8376835	+	G	G	A	Missense_Mutation	SNP	ENST00000615670.5	exon3	c.C1574T	p.S525F	exonic	ENSG00000275342.5	.	nonsynonymous SNV	ENSG00000275342.5:ENST00000615670.5:exon3:c.C1574T:p.S525F	8p23.1	C3L-01703	.	.	.	.	.	.	.	.	.	3.14	.	D	.	.	N	N	.	.	.	0.401	T	T	T	0.108	.	0.274	.	T	T	T	T	D	T	2.804	23.000	0.997	D	N	-0.137	2.060	-0.071	2.131	1.000	0.722	0.699	0.702	0.711	.	4.890	3.990	2.456	0.189	0.676	0.999	0.031	0.063	926	.	.	.	.	PRAG1	146	0	240	40	0.142857142857143	TRUE	NA
ENSG00000275342.5	.	BCM	GRCh38.p13	chr8	8376936	8376936	+	G	G	C	Missense_Mutation	SNP	ENST00000615670.5	exon3	c.C1473G	p.S491R	exonic	ENSG00000275342.5	.	nonsynonymous SNV	ENSG00000275342.5:ENST00000615670.5:exon3:c.C1473G:p.S491R	8p23.1	C3L-01703	.	.	.	.	.	.	.	.	.	6.14	.	T	.	.	N	D	.	.	.	0.576	T	T	T	0.198	.	0.192	.	T	T	D	D	D	T	3.850	26.100	0.998	D	D	0.536	5.331	0.498	5.141	1.000	0.672	0.698	0.702	0.636	.	4.780	3.910	5.505	1.176	0.676	1.000	1.000	1.000	926	.	.	.	.	PRAG1	207	0	339	65	0.160891089108911	TRUE	TRUE
ENSG00000186583.12	.	BCM	GRCh38.p13	chr8	144040819	144040819	+	G	G	A	Missense_Mutation	SNP	ENST00000377470.8	exon3	c.G1018A	p.A340T	exonic	ENSG00000186583.12	.	nonsynonymous SNV	ENSG00000186583.12:ENST00000377470.8:exon3:c.G1018A:p.A340T	8q24.3	C3L-01703	7.282e-05	0	0.0003	0	0	4.176e-05	0	0.0002	rs782325616	0.20	T	T	B	B	N	N	N	T	N	0.024	T	T	T	0.015	0.147	0.014	0.082	T	T	T	T	T	T	-0.418	0.176	0.126	N	N	-1.607	0.053	-1.594	0.077	0.831	0.517	0.547	0.479	0.563	.	4.040	-1.810	-0.192	-0.374	-0.120	0.000	0.000	0.022	970	.	.	.	.	SPATC1	103	0	138	23	0.142857142857143	TRUE	NA
ENSG00000147799.11	.	BCM	GRCh38.p13	chr8	144555632	144555632	+	G	G	T	Missense_Mutation	SNP	ENST00000276826.5	exon3	c.C524A	p.P175Q	exonic	ENSG00000147799.11	.	nonsynonymous SNV	ENSG00000147799.11:ENST00000276826.5:exon3:c.C524A:p.P175Q	8q24.3	C3L-01703	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	D	L	T	N	0.227	T	T	T	0.016	0.157	0.268	0.460	T	T	T	T	D	T	2.231	21.100	0.983	D	N	-0.009	2.478	0.131	2.865	1.000	0.633	0.547	0.659	0.755	.	4.740	4.740	4.951	1.083	0.676	0.687	0.970	0.973	883	.	.	.	.	ARHGAP39	373	0	538	38	0.0659722222222222	TRUE	TRUE
ENSG00000147799.11	.	BCM	GRCh38.p13	chr8	144555635	144555635	+	G	G	T	Missense_Mutation	SNP	ENST00000276826.5	exon3	c.C521A	p.P174Q	exonic	ENSG00000147799.11	.	nonsynonymous SNV	ENSG00000147799.11:ENST00000276826.5:exon3:c.C521A:p.P174Q	8q24.3	C3L-01703	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	D	L	T	N	0.511	T	T	T	0.080	0.247	0.289	0.637	T	T	T	T	D	T	2.267	21.400	0.975	D	N	0.150	3.088	0.238	3.377	1.000	0.633	0.547	0.659	0.755	.	4.740	4.740	3.418	1.083	0.676	0.990	0.998	0.993	883	.	.	.	.	ARHGAP39	360	0	516	34	0.0618181818181818	TRUE	TRUE
ENSG00000107863.18	.	BCM	GRCh38.p13	chr10	24594955	24594955	+	T	T	A	Missense_Mutation	SNP	ENST00000396432.7	exon21	c.A3871T	p.N1291Y	exonic	ENSG00000107863.18	.	nonsynonymous SNV	ENSG00000107863.18:ENST00000396432.7:exon21:c.A3871T:p.N1291Y	10p12.1	C3L-01703	.	.	.	.	.	.	.	.	.	13.16	D	D	.	.	D	D	.	T	D	0.961	T	T	D	0.794	.	0.639	2.770	D	.	D	D	D	D	4.268	29.300	0.994	D	D	1.038	15.146	0.935	15.334	1.000	0.563	0.602	0.602	0.636	.	5.520	5.520	8.011	1.138	0.665	1.000	1.000	0.998	962	Rho_GTPase-activating_protein_domain	.	.	.	ARHGAP21	154	0	158	23	0.12707182320442	TRUE	TRUE
ENSG00000187714.7	.	BCM	GRCh38.p13	chr10	49611279	49611279	+	C	C	T	Missense_Mutation	SNP	ENST00000374115.5	exon1	c.C539T	p.A180V	exonic	ENSG00000187714.7	.	nonsynonymous SNV	ENSG00000187714.7:ENST00000374115.5:exon1:c.C539T:p.A180V	10q11.23	C3L-01703	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	U	D	N	T	N	0.169	T	T	T	0.045	0.430	0.409	.	T	T	T	T	D	D	2.036	19.530	0.935	D	N	-0.449	1.279	-0.263	1.641	1.000	0.598	0.563	0.504	0.639	.	4.800	4.800	3.537	1.026	0.599	0.998	0.839	0.806	607	Major_facilitator_superfamily_domain	.	.	ID=COSV60320455;OCCURENCE=1(breast),1(stomach)	SLC18A3	313	0	631	84	0.117482517482517	TRUE	TRUE
ENSG00000176742.2	.	BCM	GRCh38.p13	chr11	5199918	5199918	+	G	G	T	Nonsense_Mutation	SNP	ENST00000321255.1	exon1	c.C783A	p.Y261X	exonic	ENSG00000176742.2	.	stopgain	ENSG00000176742.2:ENST00000321255.1:exon1:c.C783A:p.Y261X	11p15.4	C3L-01703	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	D	D	.	.	.	0.033	.	.	.	.	.	.	.	.	.	D	D	.	.	6.160	35	0.993	N	N	0.114	2.943	-0.173	1.852	0.016	0.487	0.574	0.547	0.613	.	5.150	1.020	-0.519	-0.410	0.676	0.000	0.036	0.020	861	GPCR,_rhodopsin-like,_7TM	.	.	.	OR51V1	186	1	257	42	0.140468227424749	TRUE	TRUE
ENSG00000134824.14	.	BCM	GRCh38.p13	chr11	61840406	61840406	+	G	G	A	Missense_Mutation	SNP	ENST00000278840.9	exon3	c.G391A	p.V131M	exonic	ENSG00000134824.14	.	nonsynonymous SNV	ENSG00000134824.14:ENST00000278840.9:exon3:c.G391A:p.V131M	11q12.2	C3L-01703	1.647e-05	0	0	0	0	2.997e-05	0	0	rs767852784	0.20	T	T	B	B	N	N	N	T	N	0.101	T	T	T	0.022	0.517	0.447	1.094	T	T	T	T	T	T	0.459	6.067	0.904	N	N	-1.244	0.198	-1.225	0.263	0.996	0.672	0.702	0.702	0.711	.	4.650	-2.890	-0.379	-1.053	-1.848	0.000	0.981	0.850	789	.	.	.	ID=COSV53898514;OCCURENCE=2(breast)	FADS2	587	0	847	90	0.096051227321238	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3L-01703	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	391	1	594	76	0.113432835820896	TRUE	TRUE
ENSG00000111344.11	.	BCM	GRCh38.p13	chr12	113104255	113104255	+	C	C	T	Missense_Mutation	SNP	ENST00000261729.9	exon18	c.G1871A	p.R624H	exonic	ENSG00000111344.11	.	nonsynonymous SNV	ENSG00000111344.11:ENST00000261729.9:exon18:c.G1871A:p.R624H	12q24.13	C3L-01703	.	.	.	.	.	.	.	.	.	15.19	D	D	B	B	N	D	M	D	D	0.190	D	D	D	0.486	0.582	0.942	2.108	.	D	D	D	D	T	3.334	24.200	0.999	D	D	0.080	2.810	0.137	2.890	1.000	0.447	0.492	0.522	0.530	.	4.700	3.790	3.436	0.096	0.469	1.000	0.996	0.958	661	Pleckstrin_homology_domain	.	.	.	RASAL1	147	1	313	39	0.110795454545455	TRUE	TRUE
ENSG00000197991.11	.	BCM	GRCh38.p13	chr13	61413024	61413024	+	A	A	G	Missense_Mutation	SNP	ENST00000409204.4	exon2	c.T1075C	p.Y359H	exonic	ENSG00000197991.11;ENSG00000280165.1	.	nonsynonymous SNV	ENSG00000280165.1:ENST00000409204.4:exon2:c.T1075C:p.Y359H,ENSG00000197991.11:ENST00000409186.1:exon5:c.T1075C:p.Y359H	13q21.2	C3L-01703	.	.	.	.	.	.	.	.	.	11.18	D	D	.	.	D	D	L	T	D	0.834	T	T	D	0.401	0.689	0.341	0.908	T	T	D	T	D	D	3.962	26.700	0.998	D	D	0.711	7.279	0.716	8.072	1.000	0.625	0.590	0.687	0.530	.	5.680	5.680	7.472	1.312	0.756	1.000	0.997	0.976	961	Cadherin-like	.	.	.	AL592490.1	189	0	245	23	0.0858208955223881	TRUE	TRUE
ENSG00000100557.9	.	BCM	GRCh38.p13	chr14	57493636	57493636	+	G	G	C	Missense_Mutation	SNP	ENST00000216445.7	exon1	c.C80G	p.S27W	exonic	ENSG00000100557.9	.	nonsynonymous SNV	ENSG00000100557.9:ENST00000216445.7:exon1:c.C80G:p.S27W	14q22.3	C3L-01703	.	.	.	.	.	.	.	.	rs201357909	6.18	D	D	D	D	N	N	.	T	D	0.370	T	T	T	0.082	.	0.631	0.066	.	T	T	T	D	T	1.901	18.500	0.985	N	N	-0.259	1.717	-0.437	1.306	1.000	0.497	0.476	0.476	0.542	.	5.110	2.220	0.204	0.203	-0.244	0.033	0.096	0.161	901	.	.	.	.	CCDC198	488	0	718	76	0.0957178841309824	TRUE	TRUE
ENSG00000100578.17	.	BCM	GRCh38.p13	chr14	58488673	58488673	+	C	C	T	Nonsense_Mutation	SNP	ENST00000619416.4	exon25	c.C3535T	p.Q1179X	exonic	ENSG00000100578.17	.	stopgain	ENSG00000100578.17:ENST00000619416.4:exon25:c.C3535T:p.Q1179X	14q23.1	C3L-01703	8.285e-06	0.0001	0	0	0	0	0	0	rs373763986	3.6	.	.	.	.	N	A	.	.	.	0.293	.	.	.	.	.	.	.	.	.	D	D	.	.	7.660	39	0.997	N	N	0.659	6.577	0.502	5.175	1.000	0.840	0.696	0.693	0.831	.	5.380	5.380	1.974	1.026	0.549	0.590	0.983	0.980	800	.	.	.	.	KIAA0586	390	0	512	62	0.10801393728223	TRUE	NA
ENSG00000138587.6	.	BCM	GRCh38.p13	chr15	56429168	56429168	+	A	A	T	Missense_Mutation	SNP	ENST00000260453.4	exon10	c.T1421A	p.I474N	exonic	ENSG00000138587.6	.	nonsynonymous SNV	ENSG00000138587.6:ENST00000260453.4:exon10:c.T1421A:p.I474N	15q21.3	C3L-01703	.	.	.	.	.	.	.	.	.	9.20	D	D	P	P	N	D	M	T	D	0.533	T	T	T	0.239	0.574	0.498	0.176	T	T	T	T	D	D	3.910	26.400	0.993	D	D	0.517	5.167	0.597	6.181	1.000	0.713	0.636	0.673	0.297	.	6.080	6.080	6.497	1.290	0.665	0.998	1.000	0.998	413	.	.	.	.	MNS1	194	0	234	20	0.078740157480315	TRUE	TRUE
ENSG00000196557.13	.	BCM	GRCh38.p13	chr16	1209032	1209032	+	G	G	A	Missense_Mutation	SNP	ENST00000348261.11	exon17	c.G3364A	p.A1122T	exonic	ENSG00000196557.13	.	nonsynonymous SNV	ENSG00000196557.13:ENST00000348261.11:exon17:c.G3364A:p.A1122T	16p13.3	C3L-01703	0	0	0	0	0	0	0	0	rs748029194	7.20	T	T	P	B	N	D	L	D	N	0.146	T	D	D	0.254	0.213	0.838	.	T	T	T	T	T	D	1.844	18.060	0.969	D	D	-0.300	1.613	-0.325	1.514	0.001	0.718	0.547	0.571	0.563	.	3.670	1.510	0.697	0.090	0.614	1.000	0.102	0.066	934	.	.	.	.	CACNA1H	39	0	117	10	0.078740157480315	TRUE	NA
ENSG00000167207.13	.	BCM	GRCh38.p13	chr16	50707880	50707880	+	C	C	T	Missense_Mutation	SNP	ENST00000300589.6	exon3	c.C566T	p.T189M	exonic	ENSG00000167207.13	.	nonsynonymous SNV	ENSG00000167207.13:ENST00000300589.6:exon3:c.C566T:p.T189M	16q12.1	C3L-01703	0.0026	0.0020	0.0002	0.0001	0.0009	0.0043	0	0	rs61755182	7.20	D	D	D	D	N	N	M	T	N	0.248	T	T	T	0.039	.	0.837	0.469	T	T	T	T	T	D	3.430	24.500	0.999	D	N	0.435	4.569	0.417	4.481	1.000	0.563	0.654	0.618	0.613	.	4.710	3.620	2.691	1.015	0.599	0.965	0.985	0.986	697	CARD_domain	.	.	ID=COSV99039070;OCCURENCE=2(lung)	NOD2	539	0	873	105	0.107361963190184	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674221	7674221	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.C742T	p.R248W	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.C742T:p.R248W	17p13.1	C3L-01703	8.24e-06	0	0	0	0	1.498e-05	0	0	rs121912651	19.20	D	D	D	D	D	A	M	D	D	0.991	D	D	D	0.927	0.986	0.984	0.393	T	D	D	D	D	D	4.158	28.300	0.999	D	D	0.506	5.084	0.371	4.161	0.000	0.722	0.702	0.725	0.735	.	4.620	2.560	0.835	1.157	0.672	1.000	0.987	0.874	433	p53,_DNA-binding_domain	.	.	ID=COSV52662035;OCCURENCE=1(salivary_gland),114(breast),1(penis),5(liver),2(genital_tract),65(oesophagus),1(cervix),238(large_intestine),62(central_nervous_system),12(biliary_tract),49(ovary),4(vulva),2(pleura),2(bone),9(NS),63(haematopoietic_and_lymphoid_tissue),52(stomach),14(kidney),11(soft_tissue),27(urinary_tract),40(pancreas),52(skin),14(prostate),47(lung),8(thyroid),51(upper_aerodigestive_tract),1(thymus),30(endometrium)	TP53	382	0	511	52	0.0923623445825933	TRUE	TRUE
ENSG00000275489.1	.	BCM	GRCh38.p13	chr17	38841310	38841310	+	C	C	T	Missense_Mutation	SNP	ENST00000614158.1	exon1	c.G80A	p.R27H	exonic	ENSG00000275489.1	.	nonsynonymous SNV	ENSG00000275489.1:ENST00000614158.1:exon1:c.G80A:p.R27H	17q12	C3L-01703	.	.	.	.	.	.	.	.	.	0.15	.	T	B	B	N	N	L	.	.	0.174	T	T	T	0.014	0.353	0.014	.	.	T	T	T	T	.	1.365	14.840	0.986	N	N	-1.013	0.390	-0.974	0.522	1.000	0.370	0.547	0.547	0.651	.	5.380	0.988	0.780	-0.277	-0.262	0.316	0.006	0.013	410	.	.	.	.	C17orf98	209	0	396	39	0.0896551724137931	TRUE	TRUE
ENSG00000008838.20	.	BCM	GRCh38.p13	chr17	40026981	40026981	+	C	C	A	Missense_Mutation	SNP	ENST00000394128.7	exon17	c.G1584T	p.W528C	exonic	ENSG00000008838.20	.	nonsynonymous SNV	ENSG00000008838.20:ENST00000394128.7:exon17:c.G1584T:p.W528C	17q21.1	C3L-01703	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.985	T	T	D	0.751	0.766	0.774	1.409	T	D	D	D	D	D	4.484	32	0.922	D	D	0.486	4.928	0.413	4.455	1.000	0.731	0.636	0.780	0.649	.	4.500	3.540	7.684	1.026	0.599	1.000	1.000	0.998	173	Mediator_complex,_subunit_Med24,_N-terminal	.	.	.	MED24	339	0	570	35	0.0578512396694215	TRUE	TRUE
ENSG00000168517.10	.	BCM	GRCh38.p13	chr17	45169571	45169571	+	G	G	A	Missense_Mutation	SNP	ENST00000307275.7	exon4	c.G623A	p.R208H	exonic	ENSG00000168517.10	.	nonsynonymous SNV	ENSG00000168517.10:ENST00000307275.7:exon4:c.G623A:p.R208H	17q21.31	C3L-01703	.	.	.	.	.	.	.	.	rs543496832	5.19	T	T	D	P	D	N	L	.	N	0.366	T	T	T	0.087	0.278	0.770	1.551	T	T	T	T	D	D	3.376	24.300	0.999	D	N	0.290	3.727	0.249	3.435	1.000	0.758	0.634	0.692	0.568	.	4.640	2.630	2.070	1.157	0.654	1.000	1.000	0.982	648	.	.	.	.	HEXIM2	100	1	175	12	0.0641711229946524	TRUE	NA
ENSG00000179855.9	.	BCM	GRCh38.p13	chr19	3585641	3585641	+	C	C	T	Missense_Mutation	SNP	ENST00000644452.3	exon1	c.C44T	p.P15L	exonic	ENSG00000179855.9	.	nonsynonymous SNV	ENSG00000179855.9:ENST00000644452.3:exon1:c.C44T:p.P15L	19p13.3	C3L-01703	.	.	.	.	.	.	.	.	.	3.20	T	D	B	B	U	N	N	T	N	0.108	T	T	D	0.164	0.186	0.735	0.101	D	T	T	T	T	T	1.452	15.430	0.956	N	N	-0.888	0.535	-0.855	0.682	1.000	0.455	0.578	0.607	0.555	.	2.970	0.656	0.865	0.756	0.423	0.934	0.123	0.174	976	.	.	.	.	GIPC3	10	0	38	14	0.269230769230769	TRUE	NA
ENSG00000181894.15	.	BCM	GRCh38.p13	chr19	58128489	58128489	+	C	C	T	Missense_Mutation	SNP	ENST00000598312.6	exon4	c.G1015A	p.G339S	exonic	ENSG00000181894.15	.	nonsynonymous SNV	ENSG00000181894.15:ENST00000598312.6:exon4:c.G1015A:p.G339S	19q13.43	C3L-01703	2.479e-05	0	8.637e-05	0	0	0	0	0.0001	rs749321833	8.20	D	D	D	D	N	D	L	T	D	0.383	T	T	D	0.252	0.678	0.590	0.462	T	T	T	T	D	T	2.762	22.900	0.999	N	N	0.577	5.694	0.529	5.430	1.000	0.707	0.709	0.725	0.636	.	4.310	4.310	2.599	1.015	0.513	0.846	0.931	0.952	964	Zinc_finger_C2H2-type	.	.	.	ZNF329	127	1	180	21	0.104477611940299	TRUE	NA
ENSG00000185340.15	.	BCM	GRCh38.p13	chr22	29312388	29312388	+	G	G	A	Missense_Mutation	SNP	ENST00000618518.3	exon5	c.G1937A	p.R646H	exonic	ENSG00000185340.15	.	nonsynonymous SNV	ENSG00000185340.15:ENST00000618518.3:exon5:c.G1937A:p.R646H	22q12.2	C3L-01703	1.774e-05	0	0	0.0001	0	0	0	7.781e-05	rs149600937	8.19	D	D	B	B	U	D	.	T	N	0.452	T	T	D	0.082	.	0.765	.	D	T	T	T	D	D	3.051	23.500	0.996	D	N	-0.287	1.646	-0.204	1.776	1.000	0.707	0.578	0.723	0.714	.	4.080	1.990	2.048	1.176	0.618	0.034	1.000	0.917	480	.	.	.	.	GAS2L1	54	0	93	23	0.198275862068966	TRUE	NA
ENSG00000100320.23	.	BCM	GRCh38.p13	chr22	35746486	35746486	+	C	C	A	Missense_Mutation	SNP	ENST00000438146.7	exon12	c.G1225T	p.A409S	exonic	ENSG00000100320.23	.	nonsynonymous SNV	ENSG00000100320.23:ENST00000438146.7:exon12:c.G1225T:p.A409S	22q12.3	C3L-01703	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	D	D	.	T	N	0.663	D	T	D	0.219	0.473	0.386	2.098	T	T	T	T	D	D	3.806	25.900	0.997	D	D	0.602	5.948	0.624	6.533	1.000	0.707	0.563	0.725	0.711	.	5.150	5.150	4.998	1.026	0.599	1.000	1.000	0.995	878	Fox-1_C-terminal_domain	.	.	.	RBFOX2	82	0	128	16	0.111111111111111	TRUE	TRUE
ENSG00000187754.9	.	BCM	GRCh38.p13	chrX	52653460	52653460	+	C	C	T	Missense_Mutation	SNP	ENST00000298181.6	exon2	c.G13A	p.D5N	exonic	ENSG00000187754.9	.	nonsynonymous SNV	ENSG00000187754.9:ENST00000298181.6:exon2:c.G13A:p.D5N	Xp11.22	C3L-01703	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	N	N	L	T	N	0.092	T	T	T	0.012	0.226	0.124	0.012	.	T	T	T	T	T	-0.017	1.233	0.570	N	.	.	.	.	.	0.000	.	.	.	.	.	0.560	-1.120	-0.211	-0.905	0.282	0.000	0.000	0.000	484	.	.	.	.	SSX7	278	0	455	108	0.191829484902309	NA	TRUE
ENSG00000147256.12	.	BCM	GRCh38.p13	chrX	131083964	131083964	+	C	C	T	Missense_Mutation	SNP	ENST00000276211.10	exon4	c.C550T	p.R184C	exonic	ENSG00000147256.12	.	nonsynonymous SNV	ENSG00000147256.12:ENST00000276211.10:exon4:c.C550T:p.R184C	Xq26.1	C3L-01703	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	D	D	M	T	D	0.483	T	T	D	0.242	0.512	0.407	1.840	T	T	T	T	D	D	4.145	28.200	0.999	D	.	.	.	.	.	0.992	.	.	.	.	.	4.240	4.240	2.966	0.947	0.599	0.990	0.962	0.972	512	.	.	.	.	ARHGAP36	119	0	176	47	0.210762331838565	TRUE	TRUE
ENSG00000143473.13	.	BCM	GRCh38.p13	chr1	210683997	210683997	+	G	G	A	Silent	SNP	ENST00000271751.10	exon11	c.C2254T	p.L752L	exonic	ENSG00000143473.13	.	synonymous SNV	ENSG00000143473.13:ENST00000271751.10:exon11:c.C2254T:p.L752L	1q32.2	C3L-01703	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCNH1	47	0	114	17	0.129770992366412	TRUE	TRUE
ENSG00000218819.6	.	BCM	GRCh38.p13	chr2	21141040	21141040	+	C	C	T	Silent	SNP	ENST00000405799.3	exon4	c.C3573T	p.S1191S	exonic	ENSG00000218819.6	.	synonymous SNV	ENSG00000218819.6:ENST00000405799.3:exon4:c.C3573T:p.S1191S	2p24.1	C3L-01703	.	.	.	.	.	.	.	.	rs563732296	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TDRD15	231	0	247	21	0.0783582089552239	TRUE	NA
ENSG00000155890.4	.	BCM	GRCh38.p13	chr3	140682978	140682978	+	C	C	T	Silent	SNP	ENST00000286349.4	exon2	c.C858T	p.D286D	exonic	ENSG00000155890.4	.	synonymous SNV	ENSG00000155890.4:ENST00000286349.4:exon2:c.C858T:p.D286D	3q23	C3L-01703	8.238e-06	0	0	0	0	1.499e-05	0	0	rs749484750	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIM42	507	0	810	86	0.0959821428571429	TRUE	NA
ENSG00000038382.20	.	BCM	GRCh38.p13	chr5	14471389	14471389	+	G	G	A	Silent	SNP	ENST00000344204.9	exon38	c.G5835A	p.S1945S	exonic	ENSG00000038382.20	.	synonymous SNV	ENSG00000038382.20:ENST00000344204.9:exon38:c.G5835A:p.S1945S	5p15.2	C3L-01703	4.969e-05	0.0005	8.697e-05	0	0	0	0	0	rs368260455	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIO	331	0	453	54	0.106508875739645	TRUE	NA
ENSG00000146063.20	.	BCM	GRCh38.p13	chr5	181224554	181224554	+	G	G	A	Silent	SNP	ENST00000315073.10	exon1	c.G555A	p.Q185Q	exonic	ENSG00000146063.20	.	synonymous SNV	ENSG00000146063.20:ENST00000315073.10:exon1:c.G555A:p.Q185Q	5q35.3	C3L-01703	.	.	.	.	.	.	.	.	rs900162156	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIM41	182	0	313	40	0.113314447592068	TRUE	NA
ENSG00000275342.5	.	BCM	GRCh38.p13	chr8	8376981	8376981	+	G	G	A	Silent	SNP	ENST00000615670.5	exon3	c.C1428T	p.V476V	exonic	ENSG00000275342.5	.	synonymous SNV	ENSG00000275342.5:ENST00000615670.5:exon3:c.C1428T:p.V476V	8p23.1	C3L-01703	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58165677;OCCURENCE=1(skin)	PRAG1	153	0	278	47	0.144615384615385	TRUE	TRUE
ENSG00000159921.17	.	BCM	GRCh38.p13	chr9	36246287	36246287	+	G	G	A	Silent	SNP	ENST00000642385.2	exon3	c.C360T	p.A120A	exonic	ENSG00000159921.17	.	synonymous SNV	ENSG00000159921.17:ENST00000642385.2:exon3:c.C360T:p.A120A	9p13.3	C3L-01703	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GNE	372	1	516	70	0.119453924914676	TRUE	TRUE
ENSG00000103546.18	.	BCM	GRCh38.p13	chr16	55672155	55672155	+	G	G	A	Silent	SNP	ENST00000379906.6	exon3	c.G624A	p.T208T	exonic	ENSG00000103546.18	.	synonymous SNV	ENSG00000103546.18:ENST00000379906.6:exon3:c.G624A:p.T208T	16q12.2	C3L-01703	8.24e-05	0	0.0003	0	0	0.0001	0	0	rs773801761	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC6A2	290	0	519	55	0.0958188153310105	TRUE	NA
ENSG00000215368.5	.	BCM	GRCh38.p13	chr18	5133163	5133163	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000215368.5	.	.	.	18p11.31	C3L-01703	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BOD1P2	40	0	79	7	0.0813953488372093	TRUE	NA
ENSG00000184478.7	.	BCM	GRCh38.p13	chr11	5947348	5947349	+	TG	TG	AT	Unknown	MNP	ENST00000641905.1	exon4	c.2_3delinsAT	p.M1?	exonic	ENSG00000184478.7	.	startloss	ENSG00000184478.7:ENST00000641905.1:exon4:c.2_3delinsAT:p.M1?	11p15.4	C3L-01703	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR56A3	99	18	131	18	0.120805369127517	TRUE	NA
ENSG00000270601.4	.	BCM	GRCh38.p13	chr1	13260284	13260284	+	C	C	A	Missense_Mutation	SNP	ENST00000622421.2	exon3	c.C350A	p.S117Y	exonic	ENSG00000270601.4	.	nonsynonymous SNV	ENSG00000270601.4:ENST00000622421.2:exon3:c.C350A:p.S117Y	1p36.21	C3L-02118	.	.	.	.	.	.	.	.	.	3.14	.	D	.	.	N	N	M	.	.	0.376	T	T	T	0.061	.	0.014	.	T	T	T	T	D	.	2.204	20.900	0.988	N	N	-0.248	1.746	-0.461	1.265	0.000	0.487	0.574	0.574	0.564	.	1.130	1.130	0.665	-0.076	0.406	0.600	0.009	0.023	.	.	.	.	.	PRAMEF5	157	0	169	53	0.238738738738739	NA	TRUE
ENSG00000204478.9	.	BCM	GRCh38.p13	chr1	13421110	13421110	+	G	G	A	Missense_Mutation	SNP	ENST00000316412.9	exon4	c.G1280A	p.R427Q	exonic	ENSG00000204478.9	.	nonsynonymous SNV	ENSG00000204478.9:ENST00000316412.9:exon4:c.G1280A:p.R427Q	1p36.21	C3L-02118	.	.	.	.	.	.	.	.	.	0.17	T	T	.	.	N	N	.	T	N	0.050	T	T	T	0.022	0.467	0.030	.	T	T	T	T	T	T	-0.256	0.387	0.556	N	N	-0.961	0.448	-1.157	0.321	0.000	0.487	0.574	0.574	0.564	.	1.680	-0.515	-2.306	-0.122	-0.194	0.000	0.001	0.000	982	.	.	.	.	PRAMEF20	598	0	678	40	0.0557103064066852	TRUE	NA
ENSG00000143374.17	.	BCM	GRCh38.p13	chr1	150504670	150504670	+	G	G	T	Missense_Mutation	SNP	ENST00000369064.8	exon15	c.G1757T	p.R586L	exonic	ENSG00000143374.17	.	nonsynonymous SNV	ENSG00000143374.17:ENST00000369064.8:exon15:c.G1757T:p.R586L	1q21.2	C3L-02118	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	H	.	D	0.968	D	D	D	0.779	0.816	0.794	1.422	T	D	D	D	D	D	4.555	32	0.999	D	D	1.044	15.374	0.961	16.624	1.000	0.707	0.725	0.725	0.636	.	5.190	5.190	9.763	1.141	0.672	1.000	0.990	0.962	163	Threonine-tRNA_ligase_catalytic_core_domain;Aminoacyl-tRNA_synthetase,_class_II;Aminoacyl-tRNA_synthetase,_class_II_(G/_P/_S/T)	.	.	.	TARS2	199	0	303	27	0.0818181818181818	TRUE	TRUE
ENSG00000117501.14	.	BCM	GRCh38.p13	chr1	170961933	170961933	+	C	C	T	Missense_Mutation	SNP	ENST00000367758.7	exon6	c.C332T	p.T111M	exonic	ENSG00000117501.14	.	nonsynonymous SNV	ENSG00000117501.14:ENST00000367758.7:exon6:c.C332T:p.T111M	1q24.3	C3L-02118	2.115e-05	0	0	0	0	2.005e-05	0	7.206e-05	rs766660390	0.20	T	T	B	B	N	N	N	T	N	0.182	T	T	T	0.038	0.382	0.110	0.057	T	T	T	T	T	T	1.284	14.270	0.432	N	N	-1.144	0.269	-1.027	0.456	0.001	0.500	0.547	0.574	0.504	.	5.600	1.780	1.293	-0.214	-1.200	0.968	0.002	0.000	803	.	.	.	ID=COSV63012034;OCCURENCE=1(skin),1(lung)	MROH9	118	0	99	17	0.146551724137931	TRUE	TRUE
ENSG00000116199.12	.	BCM	GRCh38.p13	chr1	179066829	179066829	+	G	G	A	Missense_Mutation	SNP	ENST00000263733.5	exon7	c.G968A	p.S323N	exonic	ENSG00000116199.12	.	nonsynonymous SNV	ENSG00000116199.12:ENST00000263733.5:exon7:c.G968A:p.S323N	1q25.2	C3L-02118	.	.	.	.	.	.	.	.	.	15.20	D	T	D	P	D	D	M	T	N	0.872	D	D	D	0.563	0.860	0.831	0.507	D	D	D	T	D	D	4.313	29.700	0.996	D	D	0.840	9.604	0.823	10.830	1.000	0.707	0.709	0.725	0.714	.	5.260	5.260	9.754	1.176	0.676	1.000	1.000	0.999	497	FAM20,_C-terminal	.	.	.	FAM20B	205	0	283	18	0.0598006644518272	TRUE	TRUE
ENSG00000065413.20	.	BCM	GRCh38.p13	chr2	196993664	196993664	+	C	C	T	Missense_Mutation	SNP	ENST00000282272.15	exon27	c.G2842A	p.V948I	exonic	ENSG00000065413.20	.	nonsynonymous SNV	ENSG00000065413.20:ENST00000282272.15:exon27:c.G2842A:p.V948I	2q33.1	C3L-02118	5.746e-05	0	0	0	0	0	0	0.0001	rs572226231	0.16	T	T	.	.	N	.	N	T	N	0.133	T	T	.	0.070	.	0.297	.	T	T	T	T	T	T	0.439	5.850	0.708	N	N	-1.097	0.309	-1.045	0.435	0.003	0.707	0.725	0.547	0.621	.	5.020	-0.867	0.033	0.138	0.599	0.006	0.730	0.900	421	Ankyrin_repeat-containing_domain	.	.	.	ANKRD44	247	0	280	19	0.0635451505016722	TRUE	NA
ENSG00000144488.15	.	BCM	GRCh38.p13	chr2	238100478	238100478	+	G	G	A	Missense_Mutation	SNP	ENST00000343063.8	exon1	c.G59A	p.R20Q	exonic	ENSG00000144488.15	.	nonsynonymous SNV	ENSG00000144488.15:ENST00000343063.8:exon1:c.G59A:p.R20Q	2q37.3	C3L-02118	1.555e-05	0	0	0.0002	0	0	0	0	rs751081371	1.20	T	T	B	B	N	N	N	T	N	0.203	T	T	D	0.055	0.478	0.048	0.141	T	T	T	T	T	T	-0.845	0.020	0.916	N	N	-1.543	0.069	-1.582	0.080	1.000	0.403	0.547	0.514	0.563	.	4.370	-6.330	-1.841	-0.716	-0.897	0.000	0.021	0.219	970	Ankyrin_repeat-containing_domain	.	.	ID=COSV99615679;OCCURENCE=1(lung)	ESPNL	168	0	288	34	0.105590062111801	TRUE	NA
ENSG00000163808.17	.	BCM	GRCh38.p13	chr3	44797674	44797674	+	C	C	T	Missense_Mutation	SNP	ENST00000326047.9	exon9	c.C973T	p.R325W	exonic	ENSG00000163808.17	.	nonsynonymous SNV	ENSG00000163808.17:ENST00000326047.9:exon9:c.C973T:p.R325W	3p21.31	C3L-02118	4.949e-05	0	0	0.0001	0	1.5e-05	0	0.0002	rs375650379	18.19	D	D	D	D	D	D	M	T	D	0.948	D	D	D	0.777	0.777	0.688	0.812	D	D	D	D	D	.	4.475	32	0.999	D	D	0.355	4.078	0.253	3.452	0.452	0.707	0.654	0.725	0.636	.	5.320	3.470	2.335	0.099	-0.180	0.968	0.988	0.996	323	Kinesin_motor_domain	.	.	.	KIF15	99	0	107	15	0.122950819672131	TRUE	NA
ENSG00000081148.12	.	BCM	GRCh38.p13	chr3	101244601	101244601	+	T	T	A	Missense_Mutation	SNP	ENST00000193391.8	exon13	c.A1730T	p.K577I	exonic	ENSG00000081148.12	.	nonsynonymous SNV	ENSG00000081148.12:ENST00000193391.8:exon13:c.A1730T:p.K577I	3q12.3	C3L-02118	.	.	.	.	.	.	.	.	.	3.20	D	T	B	B	N	N	M	T	D	0.359	T	T	T	0.015	0.307	0.164	0.259	T	T	T	T	T	T	1.947	18.850	0.959	N	N	-0.934	0.478	-0.896	0.625	0.946	0.554	0.588	0.547	0.568	.	5.350	1.380	0.735	-0.251	-0.171	0.887	0.488	0.464	279	.	.	.	.	IMPG2	62	0	69	9	0.115384615384615	TRUE	TRUE
ENSG00000121577.13	.	BCM	GRCh38.p13	chr3	119660041	119660041	+	T	T	C	Missense_Mutation	SNP	ENST00000264231.7	exon1	c.A383G	p.E128G	exonic	ENSG00000121577.13	.	nonsynonymous SNV	ENSG00000121577.13:ENST00000264231.7:exon1:c.A383G:p.E128G	3q13.33	C3L-02118	.	.	.	.	.	.	.	.	.	10.20	D	D	P	P	D	D	M	T	D	0.262	T	T	T	0.151	0.547	0.500	0.074	T	T	T	T	D	D	4.206	28.700	0.997	D	D	0.245	3.509	0.248	3.428	1.000	0.660	0.694	0.547	0.568	.	5.790	3.310	5.137	1.138	0.665	1.000	1.000	0.997	564	.	.	.	.	POPDC2	145	0	170	24	0.123711340206186	TRUE	TRUE
ENSG00000182308.7	.	BCM	GRCh38.p13	chr4	41982124	41982124	+	C	C	T	Missense_Mutation	SNP	ENST00000333141.7	exon1	c.C332T	p.S111L	exonic	ENSG00000182308.7	.	nonsynonymous SNV	ENSG00000182308.7:ENST00000333141.7:exon1:c.C332T:p.S111L	4p13	C3L-02118	.	.	.	.	.	.	.	.	.	5.20	D	D	B	B	N	N	L	T	D	0.275	T	T	T	0.074	0.416	0.043	0.846	T	T	T	T	D	T	1.267	14.150	0.975	D	N	-0.591	1.004	-0.646	0.979	0.844	0.487	0.574	0.547	0.542	.	0.688	0.688	4.234	0.390	0.328	1.000	0.867	0.642	599	.	.	.	.	DCAF4L1	178	0	188	14	0.0693069306930693	TRUE	NA
ENSG00000138771.16	.	BCM	GRCh38.p13	chr4	76779002	76779002	+	A	A	G	Missense_Mutation	SNP	ENST00000296043.7	exon11	c.A5816G	p.D1939G	exonic	ENSG00000138771.16	.	nonsynonymous SNV	ENSG00000138771.16:ENST00000296043.7:exon11:c.A5816G:p.D1939G	4q21.1	C3L-02118	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	N	D	M	T	D	0.611	T	T	D	0.479	0.682	0.463	1.201	T	T	D	D	D	D	4.251	29.100	0.999	D	D	0.850	9.836	0.825	10.907	1.000	0.732	0.608	0.744	0.655	.	5.550	5.550	8.881	1.312	0.691	1.000	0.991	0.890	769	Apx/Shrm_Domain_2	.	.	.	SHROOM3	381	0	383	31	0.0748792270531401	TRUE	TRUE
ENSG00000170561.13	.	BCM	GRCh38.p13	chr5	2751215	2751215	+	G	G	A	Nonsense_Mutation	SNP	ENST00000302057.6	exon1	c.C199T	p.Q67X	exonic	ENSG00000170561.13	.	stopgain	ENSG00000170561.13:ENST00000302057.6:exon1:c.C199T:p.Q67X	5p15.33	C3L-02118	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.626	.	.	.	.	.	.	.	.	.	D	D	.	.	7.822	39	0.997	D	N	0.565	5.582	0.332	3.908	1.000	0.598	0.574	0.520	0.639	.	3.290	3.290	5.132	1.058	0.462	1.000	1.000	0.559	958	.	.	.	.	IRX2	67	0	74	18	0.195652173913043	TRUE	TRUE
ENSG00000040731.10	.	BCM	GRCh38.p13	chr5	24593405	24593405	+	G	G	A	Missense_Mutation	SNP	ENST00000264463.8	exon2	c.C86T	p.T29M	exonic	ENSG00000040731.10	.	nonsynonymous SNV	ENSG00000040731.10:ENST00000264463.8:exon2:c.C86T:p.T29M	5p14.2	C3L-02118	2.475e-05	0.0002	0	0	0	1.5e-05	0	0	rs140810299	4.20	D	D	B	B	N	N	L	T	N	0.428	T	T	T	0.097	.	0.616	0.572	T	T	T	T	T	T	3.044	23.500	0.957	D	D	-0.313	1.583	-0.214	1.753	0.000	0.487	0.574	0.574	0.564	.	4.360	2.530	7.112	0.230	-0.185	1.000	0.881	0.796	939	.	.	.	ID=COSV52574046;OCCURENCE=1(large_intestine),1(kidney)	CDH10	287	0	297	16	0.0511182108626198	TRUE	TRUE
ENSG00000198721.12	.	BCM	GRCh38.p13	chr6	4117312	4117312	+	G	G	T	Missense_Mutation	SNP	ENST00000380118.7	exon9	c.C1025A	p.P342Q	exonic	ENSG00000198721.12	.	nonsynonymous SNV	ENSG00000198721.12:ENST00000380118.7:exon9:c.C1025A:p.P342Q	6p25.2	C3L-02118	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	N	D	M	T	D	0.276	T	T	T	0.160	0.493	0.596	0.071	T	T	T	T	D	T	2.556	22.500	0.984	D	N	0.290	3.727	0.283	3.618	0.031	0.732	0.744	0.725	0.714	.	6.170	3.210	0.177	0.190	0.676	0.967	0.927	0.949	735	.	.	.	.	ECI2	71	1	80	8	0.0909090909090909	TRUE	TRUE
ENSG00000204542.3	.	BCM	GRCh38.p13	chr6	31111970	31111970	+	G	G	A	Missense_Mutation	SNP	ENST00000259870.4	exon2	c.C389T	p.A130V	exonic	ENSG00000204542.3	.	nonsynonymous SNV	ENSG00000204542.3:ENST00000259870.4:exon2:c.C389T:p.A130V	6p21.33	C3L-02118	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	T	N	0.045	T	T	T	0.035	0.118	0.048	0.253	T	T	T	T	T	.	-1.613	0.001	0.574	N	N	-2.160	0.004	-2.193	0.005	1.000	0.497	0.590	0.547	0.542	.	4.940	-9.870	-2.498	-1.393	-1.622	0.000	0.000	0.000	929	.	.	.	.	C6orf15	293	1	349	44	0.111959287531807	TRUE	NA
ENSG00000135577.4	.	BCM	GRCh38.p13	chr6	142078748	142078748	+	C	C	T	Missense_Mutation	SNP	ENST00000258042.1	exon2	c.G578A	p.S193N	exonic	ENSG00000135577.4	.	nonsynonymous SNV	ENSG00000135577.4:ENST00000258042.1:exon2:c.G578A:p.S193N	6q24.1	C3L-02118	.	.	.	.	.	.	.	.	rs745523807	0.20	T	T	B	B	N	N	L	T	N	0.209	T	T	T	0.035	0.305	0.469	0.047	T	T	T	T	T	T	1.021	11.880	0.929	N	N	-0.616	0.958	-0.476	1.240	0.000	0.487	0.574	0.547	0.542	.	5.480	3.580	0.625	1.022	0.543	0.125	0.814	0.836	928	GPCR,_rhodopsin-like,_7TM	.	.	.	NMBR	195	0	236	22	0.0852713178294574	TRUE	NA
ENSG00000078269.15	.	BCM	GRCh38.p13	chr6	158083486	158083486	+	C	C	T	Nonsense_Mutation	SNP	ENST00000355585.9	exon21	c.C2923T	p.R975X	exonic	ENSG00000078269.15	.	stopgain	ENSG00000078269.15:ENST00000355585.9:exon21:c.C2923T:p.R975X	6q25.3	C3L-02118	2.471e-05	9.612e-05	8.643e-05	0	0	1.499e-05	0	0	rs201799213	4.6	.	.	.	.	N	A	.	.	.	0.445	.	.	.	.	.	.	.	.	.	D	D	.	.	8.403	42	0.998	D	N	0.661	6.605	0.457	4.793	1.000	0.722	0.546	0.710	0.735	.	5.430	3.480	1.078	0.074	0.549	1.000	0.795	0.970	964	Domain_of_unknown_function_DUF1866	.	.	.	SYNJ2	186	0	219	35	0.137795275590551	TRUE	NA
ENSG00000173114.13	.	BCM	GRCh38.p13	chr7	111123650	111123650	+	A	A	G	Missense_Mutation	SNP	ENST00000308478.10	exon3	c.A878G	p.N293S	exonic	ENSG00000173114.13	.	nonsynonymous SNV	ENSG00000173114.13:ENST00000308478.10:exon3:c.A878G:p.N293S	7q31.1	C3L-02118	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.125	T	T	T	0.088	0.711	0.396	0.208	T	T	T	T	D	D	1.968	19.010	0.971	D	D	0.035	2.638	0.233	3.347	0.962	0.554	0.588	0.574	0.613	.	5.760	5.760	5.405	1.312	0.756	1.000	0.991	0.997	627	.	.	.	.	LRRN3	137	0	152	26	0.146067415730337	TRUE	TRUE
ENSG00000174697.5	.	BCM	GRCh38.p13	chr7	128254692	128254692	+	G	G	A	Missense_Mutation	SNP	ENST00000308868.5	exon3	c.G433A	p.V145M	exonic	ENSG00000174697.5	.	nonsynonymous SNV	ENSG00000174697.5:ENST00000308868.5:exon3:c.G433A:p.V145M	7q32.1	C3L-02118	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	N	0.608	D	T	D	0.593	0.711	0.858	1.442	T	T	D	D	D	D	3.797	25.800	0.998	D	N	0.639	6.343	0.591	6.113	0.931	0.487	0.574	0.547	0.542	.	5.540	4.630	3.699	1.176	0.676	1.000	0.996	0.941	647	.	.	.	.	LEP	181	0	227	14	0.0580912863070539	TRUE	TRUE
ENSG00000091656.19	.	BCM	GRCh38.p13	chr8	76852869	76852869	+	G	G	A	Missense_Mutation	SNP	ENST00000651372.2	exon10	c.G5948A	p.R1983H	exonic	ENSG00000091656.19	.	nonsynonymous SNV	ENSG00000091656.19:ENST00000651372.2:exon10:c.G5948A:p.R1983H	8q21.13	C3L-02118	6.019e-05	0	0	0	0	7.797e-05	0	0.0001	rs757178425	6.16	D	D	.	.	U	D	.	T	N	0.524	T	T	T	0.123	.	0.117	0.560	T	.	T	T	T	D	3.267	24.000	0.998	D	D	0.423	4.490	0.445	4.696	1.000	0.554	0.590	0.574	0.621	.	4.200	4.200	4.393	1.150	0.646	1.000	1.000	0.998	798	.	.	.	ID=COSV50506049;OCCURENCE=2(large_intestine),7(pancreas),1(lung),1(endometrium)	ZFHX4	105	0	154	20	0.114942528735632	TRUE	TRUE
ENSG00000204291.11	.	BCM	GRCh38.p13	chr9	99035098	99035098	+	C	C	T	Missense_Mutation	SNP	ENST00000375001.8	exon18	c.C2164T	p.P722S	exonic	ENSG00000204291.11	.	nonsynonymous SNV	ENSG00000204291.11:ENST00000375001.8:exon18:c.C2164T:p.P722S	9q22.33	C3L-02118	.	.	.	.	.	.	.	.	.	15.20	T	D	D	D	D	D	N	D	D	0.426	D	D	D	0.503	0.446	0.884	0.425	T	D	D	T	D	T	2.986	23.400	0.998	D	D	0.583	5.759	0.581	5.992	1.000	0.487	0.590	0.574	0.613	.	5.690	5.690	2.905	1.026	0.599	0.972	0.998	0.957	856	.	.	.	.	COL15A1	97	0	121	25	0.171232876712329	TRUE	TRUE
ENSG00000181752.3	.	BCM	GRCh38.p13	chr11	56159435	56159435	+	C	C	T	Missense_Mutation	SNP	ENST00000313447.1	exon1	c.G883A	p.E295K	exonic	ENSG00000181752.3	.	nonsynonymous SNV	ENSG00000181752.3:ENST00000313447.1:exon1:c.G883A:p.E295K	11q12.1	C3L-02118	8.343e-06	9.718e-05	0	0	0	0	0	0	rs376114385	0.20	T	T	B	B	N	N	N	T	N	0.076	T	T	T	0.120	.	0.250	0.005	T	T	T	T	T	T	0.566	7.178	0.155	N	N	-1.341	0.144	-1.053	0.426	0.000	0.487	0.574	0.574	0.564	.	3.880	3.880	0.439	0.025	-0.203	0.000	0.120	0.007	161	.	.	.	ID=COSV57888140;OCCURENCE=7(skin)	OR8K5	83	0	99	9	0.0833333333333333	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227341	25227341	+	T	T	G	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A183C	p.Q61H	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A183C:p.Q61H	12p12.1	C3L-02118	.	.	.	.	.	.	.	.	rs17851045	17.20	D	D	B	B	D	D	M	D	D	0.760	D	D	D	0.644	0.659	0.905	1.857	D	D	D	D	D	T	2.993	23.400	0.997	D	D	0.298	3.768	0.383	4.239	0.998	0.722	0.710	0.710	0.735	.	5.770	5.770	2.812	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55498802;OCCURENCE=2(breast),6(liver),1(genital_tract),1(cervix),117(large_intestine),2(central_nervous_system),17(biliary_tract),3(ovary),8(stomach),50(haematopoietic_and_lymphoid_tissue),2(urinary_tract),1(kidney),71(pancreas),2(skin),2(prostate),28(lung),1(thyroid),2(small_intestine),5(endometrium)	KRAS	183	0	223	5	0.0219298245614035	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02118	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	254	0	279	33	0.105769230769231	TRUE	TRUE
ENSG00000261308.2	.	BCM	GRCh38.p13	chr12	51821752	51821752	+	G	G	A	Missense_Mutation	SNP	ENST00000618634.2	exon2	c.C662T	p.P221L	exonic	ENSG00000261308.2	.	nonsynonymous SNV	ENSG00000261308.2:ENST00000618634.2:exon2:c.C662T:p.P221L	12q13.13	C3L-02118	.	.	.	.	.	.	.	.	.	2.7	.	.	B	B	.	.	M	.	.	.	.	.	.	.	.	.	.	D	T	.	.	.	T	2.176	20.700	0.956	N	.	.	.	.	.	1.000	0.111	0.060	0.120	0.063	0.116	4.180	2.280	2.789	0.942	0.496	0.991	0.068	0.108	478	.	.	.	.	FIGNL2	19	0	16	5	0.238095238095238	TRUE	NA
ENSG00000139318.8	.	BCM	GRCh38.p13	chr12	89350605	89350605	+	-	NA	GA	Frame_Shift_Ins	INS	ENST00000279488.8	exon2	c.820_821insTC	p.E274Vfs*7	exonic	ENSG00000139318.8	.	frameshift insertion	ENSG00000139318.8:ENST00000279488.8:exon2:c.820_821insTC:p.E274Vfs*7	12q21.33	C3L-02118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DUSP6	NA	NA	NA	NA	NA	NA	NA
ENSG00000111252.11	.	BCM	GRCh38.p13	chr12	111447531	111447531	+	A	A	G	Missense_Mutation	SNP	ENST00000341259.7	exon6	c.A1223G	p.Q408R	exonic	ENSG00000111252.11	.	nonsynonymous SNV	ENSG00000111252.11:ENST00000341259.7:exon6:c.A1223G:p.Q408R	12q24.12	C3L-02118	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	D	0.777	T	T	D	0.368	0.438	0.863	0.398	T	D	D	T	D	D	4.056	27.400	0.997	D	D	0.538	5.344	0.547	5.621	1.000	0.722	0.699	0.698	0.735	.	5.000	5.000	7.147	1.312	0.756	1.000	0.998	0.987	601	SH2_domain;SH2B3,_SH2_domain	.	.	.	SH2B3	137	1	136	14	0.0933333333333333	TRUE	NA
ENSG00000178235.8	.	BCM	GRCh38.p13	chr13	83881341	83881341	+	G	G	A	Missense_Mutation	SNP	ENST00000377084.3	exon1	c.C167T	p.P56L	exonic	ENSG00000178235.8	.	nonsynonymous SNV	ENSG00000178235.8:ENST00000377084.3:exon1:c.C167T:p.P56L	13q31.1	C3L-02118	1.65e-05	0	0	0	0	3.002e-05	0	0	rs765288417	11.20	T	D	P	B	D	D	M	T	D	0.642	T	T	T	0.212	0.678	0.162	0.742	D	D	T	T	D	D	3.027	23.500	0.994	D	D	0.418	4.456	0.495	5.111	1.000	0.658	0.588	0.619	0.564	.	4.890	4.890	8.190	1.176	0.676	1.000	1.000	0.997	973	.	.	.	.	SLITRK1	229	1	181	49	0.21304347826087	TRUE	NA
ENSG00000139908.15	.	BCM	GRCh38.p13	chr14	24206074	24206074	+	G	G	T	Missense_Mutation	SNP	ENST00000287913.10	exon1	c.G151T	p.V51L	exonic	ENSG00000139908.15	.	nonsynonymous SNV	ENSG00000139908.15:ENST00000287913.10:exon1:c.G151T:p.V51L	14q12	C3L-02118	.	.	.	.	.	.	.	.	.	7.19	D	D	P	P	N	D	L	T	N	0.496	T	T	D	0.509	0.781	0.750	0.218	T	T	T	T	D	.	3.226	23.900	0.993	D	D	0.164	3.148	0.195	3.158	1.000	0.461	0.577	0.576	0.492	.	5.270	4.380	4.609	0.222	-0.110	1.000	0.999	0.980	895	Protein_kinase_domain;Protein_kinase,_ATP_binding_site	.	.	ID=COSV104383239;OCCURENCE=1(pancreas)	TSSK4	325	0	389	30	0.0715990453460621	TRUE	TRUE
ENSG00000119715.15	.	BCM	GRCh38.p13	chr14	76491590	76491590	+	C	C	T	Missense_Mutation	SNP	ENST00000380887.7	exon8	c.C931T	p.H311Y	exonic	ENSG00000119715.15	.	nonsynonymous SNV	ENSG00000119715.15:ENST00000380887.7:exon8:c.C931T:p.H311Y	14q24.3	C3L-02118	.	.	.	.	.	.	.	.	.	12.20	T	T	P	P	D	D	L	D	N	0.627	D	D	D	0.735	0.572	0.831	0.602	T	T	D	D	D	D	2.873	23.200	0.998	D	D	0.637	6.324	0.727	8.290	1.000	0.487	0.547	0.547	0.564	.	6.060	6.060	7.905	1.022	0.596	1.000	1.000	0.997	815	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	ESRRB	290	0	324	53	0.140583554376658	TRUE	TRUE
ENSG00000172366.20	.	BCM	GRCh38.p13	chr16	642189	642189	+	C	C	A	Missense_Mutation	SNP	ENST00000307650.9	exon2	c.C122A	p.T41N	exonic	ENSG00000172366.20	.	nonsynonymous SNV	ENSG00000172366.20:ENST00000307650.9:exon2:c.C122A:p.T41N	16p13.3	C3L-02118	.	.	.	.	.	.	.	.	.	2.18	T	T	B	B	U	N	.	.	N	0.171	T	T	D	0.024	0.284	0.048	0.386	D	T	T	T	T	T	1.299	14.380	0.948	N	N	-0.831	0.611	-0.786	0.778	1.000	0.767	0.522	0.851	0.604	.	2.710	2.710	0.788	0.806	0.442	0.000	0.260	0.647	649	.	.	.	.	MCRIP2	70	0	128	22	0.146666666666667	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675088	7675088	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G524A	p.R175H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G524A:p.R175H	17p13.1	C3L-02118	8.243e-06	0	0	0	0	1.499e-05	0	0	rs28934578	19.20	D	D	D	D	D	A	M	D	D	0.938	D	D	D	0.922	0.986	0.997	1.101	T	D	D	D	D	D	2.987	23.400	0.999	D	D	0.740	7.720	0.711	7.954	1.000	0.722	0.698	0.698	0.735	.	5.410	5.410	6.163	1.026	0.599	1.000	0.996	0.919	434	p53,_DNA-binding_domain	.	.	ID=COSV52661038;OCCURENCE=13(salivary_gland),172(breast),8(penis),1(peritoneum),14(liver),118(oesophagus),6(adrenal_gland),1(meninges),5(cervix),604(large_intestine),116(central_nervous_system),23(biliary_tract),94(ovary),9(vulva),2(pleura),5(bone),6(NS),124(stomach),74(haematopoietic_and_lymphoid_tissue),14(soft_tissue),21(kidney),38(urinary_tract),75(pancreas),10(skin),28(prostate),47(lung),14(thyroid),109(upper_aerodigestive_tract),1(testis),1(eye),3(small_intestine),31(endometrium)	TP53	282	0	321	47	0.127717391304348	TRUE	TRUE
ENSG00000277363.5	.	BCM	GRCh38.p13	chr17	38559653	38559653	+	G	G	A	Missense_Mutation	SNP	ENST00000617146.5	exon10	c.C1957T	p.H653Y	exonic	ENSG00000277363.5	.	nonsynonymous SNV	ENSG00000277363.5:ENST00000617146.5:exon10:c.C1957T:p.H653Y	17q12	C3L-02118	.	.	.	.	.	.	.	.	.	4.12	.	T	.	.	N	D	.	.	.	0.367	T	T	T	0.080	.	0.043	.	T	.	T	T	D	.	2.681	22.800	0.990	D	D	-0.171	1.959	-0.031	2.255	1.000	0.685	0.552	0.674	0.639	.	5.010	3.890	6.089	1.176	0.676	1.000	0.998	0.902	192	.	.	.	.	SRCIN1	160	0	254	45	0.150501672240803	TRUE	NA
ENSG00000167850.4	.	BCM	GRCh38.p13	chr17	74544819	74544819	+	G	G	A	Nonsense_Mutation	SNP	ENST00000330793.2	exon2	c.C190T	p.R64X	exonic	ENSG00000167850.4	.	stopgain	ENSG00000167850.4:ENST00000330793.2:exon2:c.C190T:p.R64X	17q25.1	C3L-02118	0.0003	0.0021	0.0003	0.0005	0	4.495e-05	0	6.057e-05	rs59461308	2.6	.	.	.	.	N	A	.	.	.	0.056	.	.	.	.	.	.	.	.	.	T	D	.	.	4.270	29.300	0.991	N	N	-0.142	2.045	-0.573	1.087	1.000	0.554	0.588	0.547	0.564	.	3.280	-2.040	-1.336	-0.440	-0.824	0.000	0.000	0.000	793	Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV58170375;OCCURENCE=1(large_intestine),3(skin)	CD300C	209	0	230	27	0.105058365758755	NA	TRUE
ENSG00000160877.6	.	BCM	GRCh38.p13	chr19	13137367	13137367	+	T	T	C	Missense_Mutation	SNP	ENST00000292431.5	exon4	c.T1217C	p.F406S	exonic	ENSG00000160877.6	.	nonsynonymous SNV	ENSG00000160877.6:ENST00000292431.5:exon4:c.T1217C:p.F406S	19p13.13	C3L-02118	8.343e-06	0	0	0	0	0	0	6.069e-05	rs531044891	10.20	D	D	P	P	N	D	N	T	D	0.906	T	T	D	0.306	0.804	0.339	2.854	D	D	T	T	D	T	3.995	26.900	0.995	D	D	0.030	2.621	0.041	2.505	1.000	0.707	0.702	0.702	0.714	.	4.860	3.840	7.938	1.134	-0.137	1.000	1.000	0.733	754	BEN_domain	.	.	.	NACC1	75	0	119	28	0.19047619047619	TRUE	NA
ENSG00000133422.13	.	BCM	GRCh38.p13	chr22	30941891	30941891	+	G	G	A	Missense_Mutation	SNP	ENST00000397641.8	exon8	c.C698T	p.T233M	exonic	ENSG00000133422.13	.	nonsynonymous SNV	ENSG00000133422.13:ENST00000397641.8:exon8:c.C698T:p.T233M	22q12.2	C3L-02118	.	.	.	.	.	.	.	.	rs924468105	7.20	T	T	D	P	D	D	L	T	N	0.334	T	T	T	0.156	0.324	0.213	1.147	T	T	T	T	D	D	3.972	26.800	0.986	D	D	0.685	6.921	0.705	7.840	1.000	0.707	0.654	0.725	0.714	.	5.680	5.680	7.367	1.176	0.676	1.000	1.000	0.863	641	.	.	.	.	MORC2	110	0	107	26	0.195488721804511	TRUE	NA
ENSG00000073150.14	.	BCM	GRCh38.p13	chr22	50177377	50177377	+	T	T	C	Missense_Mutation	SNP	ENST00000395842.3	exon2	c.T665C	p.F222S	exonic	ENSG00000073150.14	.	nonsynonymous SNV	ENSG00000073150.14:ENST00000395842.3:exon2:c.T665C:p.F222S	22q13.33	C3L-02118	.	.	.	.	.	.	.	.	.	10.20	T	D	P	P	D	D	N	T	N	0.845	T	T	T	0.323	0.665	0.296	3.285	D	T	D	D	D	D	3.657	25.200	0.997	D	D	0.346	4.027	0.428	4.559	1.000	0.718	0.588	0.571	0.700	.	5.070	5.070	7.584	1.135	0.665	1.000	1.000	0.999	702	.	.	.	.	PANX2	105	0	167	11	0.0617977528089888	TRUE	TRUE
ENSG00000187754.9	.	BCM	GRCh38.p13	chrX	52648325	52648325	+	G	G	T	Missense_Mutation	SNP	ENST00000298181.6	exon6	c.C402A	p.N134K	exonic	ENSG00000187754.9	.	nonsynonymous SNV	ENSG00000187754.9:ENST00000298181.6:exon6:c.C402A:p.N134K	Xp11.22	C3L-02118	.	.	.	.	.	.	.	.	.	1.18	T	T	B	B	N	N	M	T	N	0.141	T	T	T	0.039	0.291	0.014	0.012	.	T	T	T	T	T	-1.160	0.003	0.348	N	.	.	.	.	.	0.173	.	.	.	.	.	0.560	-1.120	-1.418	-1.451	-2.804	0.000	0.000	0.000	484	.	.	.	.	SSX7	196	1	222	12	0.0512820512820513	TRUE	TRUE
ENSG00000102053.12	.	BCM	GRCh38.p13	chrX	65502161	65502161	+	G	G	A	Missense_Mutation	SNP	ENST00000338957.4	exon5	c.G1463A	p.R488H	exonic	ENSG00000102053.12	.	nonsynonymous SNV	ENSG00000102053.12:ENST00000338957.4:exon5:c.G1463A:p.R488H	Xq12	C3L-02118	.	.	.	.	.	.	.	.	.	6.17	D	T	.	.	D	D	N	T	N	0.480	T	T	T	0.211	.	0.428	1.589	T	T	T	T	D	D	3.913	26.400	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.700	4.700	7.951	1.176	0.676	1.000	1.000	0.994	434	.	.	.	.	ZC3H12B	117	0	131	10	0.0709219858156028	TRUE	TRUE
ENSG00000028137.19	.	BCM	GRCh38.p13	chr1	12202092	12202092	+	G	G	A	Silent	SNP	ENST00000376259.7	exon9	c.G1026A	p.A342A	exonic	ENSG00000028137.19	.	synonymous SNV	ENSG00000028137.19:ENST00000376259.7:exon9:c.G1026A:p.A342A	1p36.22	C3L-02118	2.73e-05	0	0	0	0	5.391e-05	0	0	rs776068574	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66164008;OCCURENCE=1(stomach)	TNFRSF1B	231	0	370	36	0.0886699507389163	TRUE	TRUE
ENSG00000173175.14	.	BCM	GRCh38.p13	chr3	123286799	123286799	+	G	G	A	Silent	SNP	ENST00000462833.5	exon20	c.C3543T	p.I1181I	exonic	ENSG00000173175.14	.	synonymous SNV	ENSG00000173175.14:ENST00000462833.5:exon20:c.C3543T:p.I1181I	3q21.1	C3L-02118	2.595e-05	0.0003	0	0	0	0	0	0	rs746474779	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59199681;OCCURENCE=1(biliary_tract)	ADCY5	76	0	114	11	0.088	TRUE	TRUE
ENSG00000039600.11	.	BCM	GRCh38.p13	chr5	157646761	157646761	+	G	G	A	Silent	SNP	ENST00000265007.11	exon3	c.C1263T	p.S421S	exonic	ENSG00000039600.11	.	synonymous SNV	ENSG00000039600.11:ENST00000265007.11:exon3:c.C1263T:p.S421S	5q33.3	C3L-02118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SOX30	342	1	264	53	0.167192429022082	TRUE	TRUE
ENSG00000197157.11	.	BCM	GRCh38.p13	chr7	127694875	127694875	+	G	G	A	Silent	SNP	ENST00000354725.8	exon3	c.G276A	p.G92G	exonic	ENSG00000197157.11	.	synonymous SNV	ENSG00000197157.11:ENST00000354725.8:exon3:c.G276A:p.G92G	7q32.1	C3L-02118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SND1	131	0	158	13	0.0760233918128655	TRUE	NA
ENSG00000148600.15	.	BCM	GRCh38.p13	chr10	84197836	84197836	+	G	G	A	Silent	SNP	ENST00000623527.4	exon4	c.G348A	p.L116L	exonic	ENSG00000148600.15	.	synonymous SNV	ENSG00000148600.15:ENST00000623527.4:exon4:c.G348A:p.L116L	10q23.1	C3L-02118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDHR1	293	0	340	49	0.125964010282776	TRUE	TRUE
ENSG00000123407.4	.	BCM	GRCh38.p13	chr12	53955229	53955229	+	C	C	T	Silent	SNP	ENST00000243103.4	exon1	c.C300T	p.A100A	exonic	ENSG00000123407.4	.	synonymous SNV	ENSG00000123407.4:ENST00000243103.4:exon1:c.C300T:p.A100A	12q13.13	C3L-02118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HOXC12	77	0	78	26	0.25	TRUE	TRUE
ENSG00000072041.17	.	BCM	GRCh38.p13	chr12	84892019	84892019	+	A	A	G	Silent	SNP	ENST00000266682.10	exon2	c.T102C	p.F34F	exonic	ENSG00000072041.17	.	synonymous SNV	ENSG00000072041.17:ENST00000266682.10:exon2:c.T102C:p.F34F	12q21.31	C3L-02118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC6A15	307	0	239	36	0.130909090909091	TRUE	TRUE
ENSG00000047346.12	.	BCM	GRCh38.p13	chr15	52610014	52610014	+	T	T	C	Silent	SNP	ENST00000261844.11	exon6	c.A900G	p.L300L	exonic	ENSG00000047346.12	.	synonymous SNV	ENSG00000047346.12:ENST00000261844.11:exon6:c.A900G:p.L300L	15q21.3	C3L-02118	4.244e-05	0.0001	0	0.0005	0	0	0	0	rs200513144	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM214A	177	0	128	15	0.104895104895105	TRUE	NA
ENSG00000149654.11	.	BCM	GRCh38.p13	chr20	46186661	46186661	+	G	G	A	Silent	SNP	ENST00000537909.4	exon10	c.C1590T	p.G530G	exonic	ENSG00000149654.11	.	synonymous SNV	ENSG00000149654.11:ENST00000537909.4:exon10:c.C1590T:p.G530G	20q13.12	C3L-02118	0.0020	0.0206	0.0007	0	0	0.0002	0.0011	0.0002	rs1883837	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100953020;OCCURENCE=2(haematopoietic_and_lymphoid_tissue)	CDH22	141	0	202	32	0.136752136752137	TRUE	NA
ENSG00000188064.10	.	BCM	GRCh38.p13	chr22	45931344	45931344	+	G	G	A	Silent	SNP	ENST00000339464.9	exon3	c.C324T	p.Y108Y	exonic	ENSG00000188064.10	.	synonymous SNV	ENSG00000188064.10:ENST00000339464.9:exon3:c.C324T:p.Y108Y	22q13.31	C3L-02118	4.611e-05	0	9.166e-05	0	0	6.732e-05	0	0	rs375198790	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59750407;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	WNT7B	77	0	116	25	0.177304964539007	TRUE	NA
ENSG00000163703.19	.	BCM	GRCh38.p13	chr3	9943944	9943944	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000163703.19;ENSG00000288550.1	.	.	.	3p25.3	C3L-02118	7.413e-05	0	0	0	0	7.492e-05	0	0.0002	rs369653816	0.18	T	T	B	B	N	N	.	T	N	0.092	T	T	T	0.071	.	0.234	0.184	T	.	T	T	T	T	-1.320	0.001	0.746	N	N	-1.611	0.053	-1.754	0.041	1.000	0.672	0.702	0.644	0.492	.	3.280	-6.330	-2.297	-2.400	-1.781	0.000	0.000	0.000	628	.	.	.	.	CRELD1	315	0	336	46	0.120418848167539	TRUE	NA
ENSG00000002079.14	.	BCM	GRCh38.p13	chr7	99296890	99296890	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000002079.14	.	.	.	7q22.1	C3L-02118	0.0002	0	0	0	0	0.0005	0	0.0001	rs777991094	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYH16	230	0	242	28	0.103703703703704	TRUE	NA
ENSG00000048392.12	.	BCM	GRCh38.p13	chr8	102238729	102238729	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000048392.12	.	.	.	8q22.3	C3L-02118	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RRM2B	266	0	434	68	0.135458167330677	TRUE	TRUE
ENSG00000156150.9	.	BCM	GRCh38.p13	chr1	110061454	110061454	+	C	C	T	Missense_Mutation	SNP	ENST00000647563.2	exon3	c.G704A	p.R235H	exonic	ENSG00000156150.9	.	nonsynonymous SNV	ENSG00000156150.9:ENST00000647563.2:exon3:c.G704A:p.R235H	1p13.3	C3L-03628	9.887e-05	0	8.637e-05	0.0006	0	0	0	0.0004	rs199753639	11.20	D	D	B	B	N	D	M	D	D	0.360	T	D	D	0.313	0.384	0.970	1.002	T	D	T	T	T	D	3.002	23.400	0.998	D	N	-0.489	1.198	-0.414	1.348	1.000	0.737	0.380	0.733	0.684	.	4.980	3.110	4.983	-1.326	-1.865	0.999	0.009	0.758	429	.	.	.	ID=COSV63928745;OCCURENCE=1(large_intestine)	ALX3	360	1	500	35	0.0654205607476635	TRUE	TRUE
ENSG00000075340.23	.	BCM	GRCh38.p13	chr2	70677859	70677859	+	C	C	T	Missense_Mutation	SNP	ENST00000264436.9	exon12	c.G1402A	p.V468M	exonic	ENSG00000075340.23	.	nonsynonymous SNV	ENSG00000075340.23:ENST00000264436.9:exon12:c.G1402A:p.V468M	2p13.3	C3L-03628	.	.	.	.	.	.	.	.	.	5.20	T	T	P	B	D	D	L	T	N	0.384	T	T	T	0.062	0.182	0.416	0.800	T	T	T	T	D	D	2.252	21.300	0.987	D	N	-0.153	2.012	0.022	2.434	0.618	0.672	0.627	0.702	0.542	.	5.400	4.520	0.842	1.026	0.599	0.203	0.995	0.991	748	.	.	.	.	ADD2	154	0	234	17	0.0677290836653386	TRUE	TRUE
ENSG00000135636.14	.	BCM	GRCh38.p13	chr2	71526263	71526263	+	G	G	A	Missense_Mutation	SNP	ENST00000258104.7	exon12	c.G1097A	p.S366N	exonic	ENSG00000135636.14	.	nonsynonymous SNV	ENSG00000135636.14:ENST00000258104.7:exon12:c.G1097A:p.S366N	2p13.2	C3L-03628	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	L	T	N	0.135	T	T	T	0.213	0.391	0.758	0.139	T	T	T	T	T	D	2.370	22.000	0.982	D	D	-0.239	1.770	-0.107	2.028	1.000	0.707	0.590	0.659	0.714	.	5.330	4.420	3.861	0.222	0.676	1.000	0.993	0.989	541	FerIin_domain	.	.	ID=COSV50301205;OCCURENCE=1(stomach)	DYSF	370	0	518	38	0.0683453237410072	TRUE	TRUE
ENSG00000154162.15	.	BCM	GRCh38.p13	chr5	21751801	21751801	+	C	C	T	Missense_Mutation	SNP	ENST00000382254.6	exon15	c.G2321A	p.R774H	exonic	ENSG00000154162.15	.	nonsynonymous SNV	ENSG00000154162.15:ENST00000382254.6:exon15:c.G2321A:p.R774H	5p14.3	C3L-03628	.	.	.	.	.	.	.	.	.	11.20	D	D	B	B	D	D	M	T	D	0.425	T	T	D	0.506	0.887	0.824	0.809	T	T	T	T	D	D	2.576	22.600	0.999	D	D	0.149	3.086	0.215	3.259	0.987	0.554	0.574	0.574	0.621	.	5.180	4.310	3.432	1.026	0.549	1.000	1.000	0.999	853	Cadherin,_cytoplasmic_domain	.	.	ID=COSV66401295;OCCURENCE=1(large_intestine),1(skin)	CDH12	246	0	304	22	0.0674846625766871	TRUE	TRUE
ENSG00000131711.15	.	BCM	GRCh38.p13	chr5	72194331	72194331	+	C	C	T	Missense_Mutation	SNP	ENST00000296755.12	exon5	c.C976T	p.R326W	exonic	ENSG00000131711.15	.	nonsynonymous SNV	ENSG00000131711.15:ENST00000296755.12:exon5:c.C976T:p.R326W	5q13.2	C3L-03628	.	.	.	.	.	.	.	.	rs200457818	17.20	D	D	D	D	D	D	M	T	D	0.942	T	T	D	0.444	0.511	0.800	0.885	D	D	D	D	D	D	3.853	26.100	0.999	D	D	0.755	7.967	0.727	8.281	1.000	0.707	0.627	0.725	0.714	.	6.170	5.230	1.250	0.124	0.599	1.000	1.000	0.998	234	.	.	.	ID=COSV57096970;OCCURENCE=2(large_intestine)	MAP1B	344	0	448	28	0.0588235294117647	TRUE	TRUE
ENSG00000196821.10	.	BCM	GRCh38.p13	chr6	34696569	34696569	+	A	A	G	Missense_Mutation	SNP	ENST00000374023.8	exon1	c.T35C	p.L12P	exonic	ENSG00000196821.10	.	nonsynonymous SNV	ENSG00000196821.10:ENST00000374023.8:exon1:c.T35C:p.L12P	6p21.31	C3L-03628	.	.	.	.	.	.	.	.	.	15.18	D	D	D	D	D	D	M	.	D	0.925	T	T	D	0.508	0.719	0.615	3.576	.	T	D	D	D	D	4.316	29.700	0.998	D	D	0.608	6.004	0.477	4.953	1.000	0.442	0.522	0.522	0.562	.	2.500	2.500	7.877	1.194	0.614	1.000	1.000	0.998	321	.	.	.	.	ILRUN	137	1	230	24	0.094488188976378	TRUE	TRUE
ENSG00000122728.6	.	BCM	GRCh38.p13	chr9	32633970	32633970	+	T	T	C	Missense_Mutation	SNP	ENST00000242310.4	exon1	c.A1610G	p.E537G	exonic	ENSG00000122728.6	.	nonsynonymous SNV	ENSG00000122728.6:ENST00000242310.4:exon1:c.A1610G:p.E537G	9p21.1	C3L-03628	.	.	.	.	.	.	.	.	.	7.20	D	T	B	B	D	D	L	T	D	0.202	T	T	T	0.106	0.162	0.370	0.163	T	T	T	T	D	D	1.731	17.240	0.993	D	N	-0.522	1.134	-0.491	1.217	0.829	0.638	0.670	0.659	0.655	.	1.160	1.160	5.218	0.298	0.266	1.000	0.718	0.429	835	.	.	.	.	TAF1L	292	0	348	31	0.0817941952506596	NA	TRUE
ENSG00000196730.13	.	BCM	GRCh38.p13	chr9	87681585	87681585	+	C	C	T	Missense_Mutation	SNP	ENST00000408954.8	exon20	c.C2183T	p.S728F	exonic	ENSG00000196730.13	.	nonsynonymous SNV	ENSG00000196730.13:ENST00000408954.8:exon20:c.C2183T:p.S728F	9q21.33	C3L-03628	.	.	.	.	.	.	.	.	.	9.20	D	D	P	B	D	D	L	T	N	0.552	T	T	D	0.185	0.188	0.642	0.769	T	T	T	T	D	D	2.637	22.700	0.995	D	D	0.330	3.937	0.353	4.044	1.000	0.707	0.725	0.725	0.714	.	5.170	5.170	4.557	1.023	0.595	1.000	0.782	0.282	865	Roc_domain	.	.	.	DAPK1	279	1	408	29	0.0663615560640732	TRUE	TRUE
ENSG00000182752.10	.	BCM	GRCh38.p13	chr9	116271390	116271390	+	G	G	A	Missense_Mutation	SNP	ENST00000328252.4	exon9	c.G2927A	p.R976Q	exonic	ENSG00000182752.10	.	nonsynonymous SNV	ENSG00000182752.10:ENST00000328252.4:exon9:c.G2927A:p.R976Q	9q33.1	C3L-03628	4.942e-05	0	0	0.0003	0	2.997e-05	0	6.057e-05	rs374222533	0.20	T	T	B	B	N	N	N	T	N	0.107	T	T	T	0.008	.	0.162	0.407	T	T	T	T	T	T	0.352	4.888	0.914	N	N	-1.424	0.107	-1.354	0.176	1.000	0.598	0.590	0.596	0.564	.	4.780	-2.840	-0.696	-1.741	-1.600	0.001	0.369	0.946	426	.	.	.	ID=COSV60281341;OCCURENCE=1(large_intestine),1(central_nervous_system)	PAPPA	213	0	325	21	0.0606936416184971	TRUE	TRUE
ENSG00000156502.14	.	BCM	GRCh38.p13	chr10	69187694	69187694	+	T	T	G	Missense_Mutation	SNP	ENST00000359655.9	exon4	c.T510G	p.F170L	exonic	ENSG00000156502.14	.	nonsynonymous SNV	ENSG00000156502.14:ENST00000359655.9:exon4:c.T510G:p.F170L	10q22.1	C3L-03628	.	.	.	.	.	.	.	.	.	15.20	D	T	D	D	D	D	M	T	D	0.741	T	T	D	0.323	0.520	0.636	1.070	D	D	D	D	D	D	3.720	25.500	0.998	D	N	0.398	4.330	0.344	3.986	0.211	0.707	0.725	0.725	0.714	.	5.370	2.620	1.458	0.197	0.665	1.000	1.000	1.000	748	.	.	.	.	SUPV3L1	123	0	219	14	0.0600858369098712	TRUE	TRUE
ENSG00000205495.1	.	BCM	GRCh38.p13	chr11	5046983	5046983	+	G	G	A	Missense_Mutation	SNP	ENST00000380370.1	exon1	c.G458A	p.R153H	exonic	ENSG00000205495.1	.	nonsynonymous SNV	ENSG00000205495.1:ENST00000380370.1:exon1:c.G458A:p.R153H	11p15.4	C3L-03628	2.477e-05	0	8.708e-05	0	0	1.501e-05	0	6.058e-05	rs759986415	4.20	D	D	B	B	N	N	M	T	D	0.092	T	T	T	0.083	0.632	0.183	0.014	T	T	T	T	T	T	0.763	9.037	0.935	N	N	-0.929	0.485	-1.065	0.413	0.001	0.487	0.574	0.492	0.564	.	4.190	1.010	-0.553	-0.608	-0.745	0.000	0.000	0.004	841	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV66746819;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(pancreas),1(small_intestine)	OR52J3	236	0	344	22	0.0601092896174863	TRUE	TRUE
ENSG00000187398.12	.	BCM	GRCh38.p13	chr11	24763291	24763291	+	C	C	T	Nonsense_Mutation	SNP	ENST00000336930.11	exon5	c.C379T	p.R127X	exonic	ENSG00000187398.12	.	stopgain	ENSG00000187398.12:ENST00000336930.11:exon5:c.C379T:p.R127X	11p14.3	C3L-03628	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.546	.	.	.	.	.	.	.	.	.	D	D	.	.	7.999	40	0.997	D	N	0.694	7.037	0.544	5.583	0.002	0.487	0.574	0.547	0.564	.	4.510	4.510	1.191	1.008	0.547	1.000	0.997	0.996	982	.	.	.	ID=COSV61204414;OCCURENCE=2(skin),1(endometrium)	LUZP2	17	0	37	6	0.13953488372093	TRUE	TRUE
ENSG00000134824.14	.	BCM	GRCh38.p13	chr11	61862974	61862974	+	C	C	A	Missense_Mutation	SNP	ENST00000278840.9	exon8	c.C885A	p.D295E	exonic	ENSG00000134824.14	.	nonsynonymous SNV	ENSG00000134824.14:ENST00000278840.9:exon8:c.C885A:p.D295E	11q12.2	C3L-03628	.	.	.	.	.	.	.	.	.	12.20	D	D	P	P	D	D	M	T	D	0.693	T	T	D	0.542	0.558	0.928	1.074	T	T	D	D	D	D	2.861	23.100	0.997	D	N	-0.039	2.375	0.015	2.411	1.000	0.672	0.702	0.702	0.711	.	5.000	4.090	1.784	1.026	0.594	0.961	0.988	0.949	779	Fatty_acid_desaturase_domain	.	.	.	FADS2	225	0	311	19	0.0575757575757576	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3L-03628	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	319	0	424	61	0.125773195876289	TRUE	TRUE
ENSG00000177169.10	.	BCM	GRCh38.p13	chr12	131909227	131909227	+	C	C	T	Missense_Mutation	SNP	ENST00000321867.6	exon8	c.C656T	p.A219V	exonic	ENSG00000177169.10	.	nonsynonymous SNV	ENSG00000177169.10:ENST00000321867.6:exon8:c.C656T:p.A219V	12q24.33	C3L-03628	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	N	T	D	0.654	T	T	D	0.334	0.599	0.368	2.237	T	T	T	T	D	D	4.127	28.000	0.999	D	D	0.529	5.269	0.548	5.631	1.000	0.707	0.644	0.571	0.714	.	4.770	4.770	7.805	1.015	0.549	1.000	0.973	0.966	976	Protein_kinase_domain	.	.	.	ULK1	135	1	227	21	0.0846774193548387	TRUE	TRUE
ENSG00000166825.14	.	BCM	GRCh38.p13	chr15	89790472	89790472	+	A	A	C	Nonsense_Mutation	SNP	ENST00000300060.7	exon20	c.T2739G	p.Y913X	exonic	ENSG00000166825.14	.	stopgain	ENSG00000166825.14:ENST00000300060.7:exon20:c.T2739G:p.Y913X	15q26.1	C3L-03628	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	D	.	.	.	0.817	.	.	.	.	.	.	.	.	.	D	D	.	.	5.880	35	0.988	N	N	-0.207	1.857	-0.577	1.080	0.995	0.672	0.547	0.659	0.711	.	4.980	-4.950	-0.456	-1.400	-0.590	0.000	0.019	0.482	476	ERAP1-like_C-terminal_domain	.	.	.	ANPEP	251	0	351	26	0.0689655172413793	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674268	7674268	+	A	A	C	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.T695G	p.I232S	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.T695G:p.I232S	17p13.1	C3L-03628	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.903	D	D	D	0.935	0.732	0.988	1.973	T	D	D	D	D	D	4.360	31	0.995	D	D	0.755	7.963	0.705	7.853	0.998	0.722	0.702	0.725	0.735	.	4.620	4.620	9.300	1.291	0.751	1.000	1.000	0.998	433	p53,_DNA-binding_domain	.	.	ID=COSV52829354;OCCURENCE=5(breast),1(liver),2(oesophagus),2(large_intestine),2(central_nervous_system),1(upper_aerodigestive_tract)	TP53	431	0	502	46	0.0839416058394161	TRUE	TRUE
ENSG00000270885.2	.	BCM	GRCh38.p13	chr17	35740532	35740532	+	A	A	G	Missense_Mutation	SNP	ENST00000603017.2	exon3	c.A340G	p.R114G	exonic	ENSG00000270885.2	.	nonsynonymous SNV	ENSG00000270885.2:ENST00000603017.2:exon3:c.A340G:p.R114G	17q12	C3L-03628	.	.	.	.	.	.	.	.	.	15.18	.	D	D	P	D	D	M	T	.	0.879	D	D	D	0.793	0.725	0.926	.	D	D	D	D	D	T	5.204	33	0.999	D	D	0.597	5.891	0.563	5.791	1.000	0.610	0.627	0.494	0.616	.	5.010	5.010	5.880	1.312	0.756	1.000	0.977	0.787	657	.	.	.	.	RASL10B	75	0	137	10	0.0680272108843537	TRUE	TRUE
ENSG00000128000.16	.	BCM	GRCh38.p13	chr19	40036440	40036440	+	T	T	C	Missense_Mutation	SNP	ENST00000434248.6	exon5	c.A419G	p.N140S	exonic	ENSG00000128000.16	.	nonsynonymous SNV	ENSG00000128000.16:ENST00000434248.6:exon5:c.A419G:p.N140S	19q13.2	C3L-03628	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	.	N	N	T	N	0.014	T	T	T	0.012	0.382	0.171	0.103	T	T	T	T	T	.	-0.770	0.030	0.362	N	N	-1.426	0.107	-1.465	0.122	0.001	0.615	0.634	0.609	0.655	.	2.110	-0.486	-0.186	-0.611	0.366	0.000	0.000	0.072	784	.	.	.	.	ZNF780B	113	0	202	14	0.0648148148148148	TRUE	TRUE
ENSG00000120500.18	.	BCM	GRCh38.p13	chrX	70277405	70277405	+	G	G	A	Missense_Mutation	SNP	ENST00000307959.9	exon9	c.G485A	p.R162Q	exonic	ENSG00000120500.18	.	nonsynonymous SNV	ENSG00000120500.18:ENST00000307959.9:exon9:c.G485A:p.R162Q	Xq13.1	C3L-03628	3.658e-05	0.0004	0	0	0	0	0	0	rs371232872	4.19	T	T	P	B	N	N	M	T	D	0.317	T	T	T	0.068	.	0.361	0.088	T	T	T	T	T	D	1.530	15.930	0.997	D	.	.	.	.	.	0.004	.	.	.	.	.	4.690	2.880	3.008	0.171	0.676	1.000	0.997	0.986	44	Arrestin-like,_N-terminal	.	.	.	ARR3	161	0	216	20	0.0847457627118644	TRUE	NA
ENSG00000165349.12	.	BCM	GRCh38.p13	chrX	70927996	70927996	+	C	C	T	Missense_Mutation	SNP	ENST00000374299.8	exon6	c.G845A	p.R282H	exonic	ENSG00000165349.12	.	nonsynonymous SNV	ENSG00000165349.12:ENST00000374299.8:exon6:c.G845A:p.R282H	Xq13.1	C3L-03628	0.0002	0.0016	0.0002	0	0	2.209e-05	0.0017	0	rs143349209	8.19	T	T	B	B	N	N	M	D	D	0.232	D	D	D	0.386	.	0.813	0.522	T	D	T	T	T	T	1.055	12.300	0.956	D	.	.	.	.	.	0.116	.	.	.	.	.	5.250	0.467	1.047	-0.712	-0.174	0.398	0.952	0.810	512	.	.	.	ID=COSV53228854;OCCURENCE=1(large_intestine),1(lung)	SLC7A3	276	0	351	30	0.078740157480315	TRUE	TRUE
ENSG00000198910.14	.	BCM	GRCh38.p13	chrX	153866709	153866709	+	C	C	T	Missense_Mutation	SNP	ENST00000370060.7	exon19	c.G2371A	p.V791I	exonic	ENSG00000198910.14	.	nonsynonymous SNV	ENSG00000198910.14:ENST00000370060.7:exon19:c.G2371A:p.V791I	Xq28	C3L-03628	.	.	.	.	.	.	.	.	rs200605257	1.19	T	T	B	B	N	D	N	T	N	0.074	T	T	T	0.020	0.470	0.307	0.467	T	T	T	T	T	T	1.453	15.430	0.948	N	.	.	.	.	.	0.253	.	.	.	.	.	5.280	2.320	0.223	0.129	-0.207	0.005	0.989	0.985	155	Fibronectin_type_III	.	.	ID=COSV62828942;OCCURENCE=1(breast),1(lung)	L1CAM	227	0	305	29	0.0868263473053892	TRUE	TRUE
ENSG00000184216.14	.	BCM	GRCh38.p13	chrX	154014070	154014070	+	C	C	T	Missense_Mutation	SNP	ENST00000369980.8	exon11	c.G1511A	p.R504Q	exonic	ENSG00000184216.14	.	nonsynonymous SNV	ENSG00000184216.14:ENST00000369980.8:exon11:c.G1511A:p.R504Q	Xq28	C3L-03628	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	L	T	D	0.275	D	D	D	0.234	0.406	0.851	1.483	T	T	T	T	D	D	3.385	24.400	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.540	4.670	3.325	1.026	0.599	1.000	1.000	0.999	76	Protein_kinase_domain	.	.	.	IRAK1	223	0	341	29	0.0783783783783784	TRUE	TRUE
ENSG00000157870.17	.	BCM	GRCh38.p13	chr1	2588600	2588600	+	C	C	T	Silent	SNP	ENST00000419916.8	exon5	c.C435T	p.S145S	exonic	ENSG00000157870.17	.	synonymous SNV	ENSG00000157870.17:ENST00000419916.8:exon5:c.C435T:p.S145S	1p36.32	C3L-03628	0.0002	0	0	0	0	3.005e-05	0	0.0011	rs536749188	1.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	0.149	2.565	0.699	N	N	-0.710	0.797	-0.798	0.760	1.000	0.706	0.710	0.723	0.714	.	4.180	-3.230	-0.984	0.102	-0.226	0.244	0.998	0.974	834	.	.	.	.	PRXL2B	143	1	229	16	0.0653061224489796	TRUE	NA
ENSG00000170396.8	.	BCM	GRCh38.p13	chr2	184598980	184598980	+	C	C	T	Silent	SNP	ENST00000302277.7	exon1	c.C21T	p.V7V	exonic	ENSG00000170396.8	.	synonymous SNV	ENSG00000170396.8:ENST00000302277.7:exon1:c.C21T:p.V7V	2q32.1	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56463713;OCCURENCE=1(lung)	ZNF804A	239	0	319	26	0.0753623188405797	TRUE	TRUE
ENSG00000060971.18	.	BCM	GRCh38.p13	chr3	38133954	38133954	+	C	C	T	Silent	SNP	ENST00000333167.13	exon3	c.G321A	p.L107L	exonic	ENSG00000060971.18	.	synonymous SNV	ENSG00000060971.18:ENST00000333167.13:exon3:c.G321A:p.L107L	3p22.2	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACAA1	165	0	264	20	0.0704225352112676	TRUE	TRUE
ENSG00000197584.12	.	BCM	GRCh38.p13	chr3	178828187	178828187	+	C	C	T	Silent	SNP	ENST00000452583.6	exon4	c.C237T	p.T79T	exonic	ENSG00000197584.12;ENSG00000275163.1	.	synonymous SNV	ENSG00000197584.12:ENST00000452583.6:exon4:c.C237T:p.T79T,ENSG00000275163.1:ENST00000614557.1:exon4:c.C237T:p.T79T	3q26.32	C3L-03628	8.318e-06	0	0	0	0	1.505e-05	0	0	rs767171556	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCNMB2	121	0	168	12	0.0666666666666667	TRUE	NA
ENSG00000184985.16	.	BCM	GRCh38.p13	chr4	7676178	7676178	+	C	C	T	Silent	SNP	ENST00000507866.6	exon9	c.C1290T	p.D430D	exonic	ENSG00000184985.16	.	synonymous SNV	ENSG00000184985.16:ENST00000507866.6:exon9:c.C1290T:p.D430D	4p16.1	C3L-03628	0	0	0	0	0	0	0	0	rs773780208	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SORCS2	253	0	342	25	0.0681198910081744	TRUE	NA
ENSG00000221818.9	.	BCM	GRCh38.p13	chr8	25844615	25844615	+	C	C	T	Silent	SNP	ENST00000520164.6	exon16	c.G1722A	p.P574P	exonic	ENSG00000221818.9	.	synonymous SNV	ENSG00000221818.9:ENST00000520164.6:exon16:c.G1722A:p.P574P	8p21.2	C3L-03628	8.286e-06	0	0	0	0	1.499e-05	0	0	rs773515338	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV68780534;OCCURENCE=1(large_intestine)	EBF2	205	0	302	17	0.0532915360501567	TRUE	NA
ENSG00000154146.13	.	BCM	GRCh38.p13	chr11	124745508	124745508	+	C	C	T	Silent	SNP	ENST00000284292.11	exon2	c.C21T	p.N7N	exonic	ENSG00000154146.13	.	synonymous SNV	ENSG00000154146.13:ENST00000284292.11:exon2:c.C21T:p.N7N	11q24.2	C3L-03628	2.693e-05	0	0	0.0002	0	0	0	7.38e-05	rs559809272	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52518053;OCCURENCE=1(large_intestine)	NRGN	54	0	84	19	0.184466019417476	TRUE	TRUE
ENSG00000109956.13	.	BCM	GRCh38.p13	chr11	134383824	134383824	+	G	G	A	Silent	SNP	ENST00000312527.9	exon3	c.C477T	p.R159R	exonic	ENSG00000109956.13	.	synonymous SNV	ENSG00000109956.13:ENST00000312527.9:exon3:c.C477T:p.R159R	11q25	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56998007;OCCURENCE=1(large_intestine),1(stomach),1(lung)	B3GAT1	297	0	415	29	0.0653153153153153	TRUE	TRUE
ENSG00000170486.11	.	BCM	GRCh38.p13	chr12	52601126	52601126	+	C	C	T	Silent	SNP	ENST00000293745.7	exon1	c.G327A	p.P109P	exonic	ENSG00000170486.11	.	synonymous SNV	ENSG00000170486.11:ENST00000293745.7:exon1:c.G327A:p.P109P	12q13.13	C3L-03628	1.649e-05	0	0	0	0.0002	1.5e-05	0	0	rs777799663	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99537223;OCCURENCE=1(large_intestine)	KRT72	268	0	306	24	0.0727272727272727	TRUE	NA
ENSG00000111249.14	.	BCM	GRCh38.p13	chr12	111298553	111298553	+	C	C	T	Silent	SNP	ENST00000261726.11	exon9	c.C717T	p.V239V	exonic	ENSG00000111249.14	.	synonymous SNV	ENSG00000111249.14:ENST00000261726.11:exon9:c.C717T:p.V239V	12q24.11	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CUX2	234	0	363	22	0.0571428571428571	TRUE	TRUE
ENSG00000110917.8	.	BCM	GRCh38.p13	chr12	120687479	120687479	+	C	C	T	Silent	SNP	ENST00000228506.8	exon1	c.C183T	p.D61D	exonic	ENSG00000110917.8	.	synonymous SNV	ENSG00000110917.8:ENST00000228506.8:exon1:c.C183T:p.D61D	12q24.31	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MLEC	71	0	93	6	0.0606060606060606	TRUE	NA
ENSG00000168904.15	.	BCM	GRCh38.p13	chr15	99352445	99352445	+	G	G	C	Silent	SNP	ENST00000301981.8	exon7	c.G669C	p.L223L	exonic	ENSG00000168904.15	.	synonymous SNV	ENSG00000168904.15:ENST00000301981.8:exon7:c.G669C:p.L223L	15q26.3	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRRC28	159	0	250	14	0.053030303030303	TRUE	NA
ENSG00000007314.12	.	BCM	GRCh38.p13	chr17	63951691	63951691	+	G	G	A	Silent	SNP	ENST00000435607.3	exon14	c.C2586T	p.D862D	exonic	ENSG00000007314.12	.	synonymous SNV	ENSG00000007314.12:ENST00000435607.3:exon14:c.C2586T:p.D862D	17q23.3	C3L-03628	9.619e-05	0	0	0.0015	0	0	0	0	rs756161095	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101438331;OCCURENCE=1(stomach)	SCN4A	238	0	386	29	0.0698795180722892	TRUE	NA
ENSG00000132016.11	.	BCM	GRCh38.p13	chr19	13889839	13889839	+	G	G	A	Silent	SNP	ENST00000586783.5	exon5	c.C1017T	p.I339I	exonic	ENSG00000132016.11	.	synonymous SNV	ENSG00000132016.11:ENST00000586783.5:exon5:c.C1017T:p.I339I	19p13.12	C3L-03628	2.543e-05	0	0	0	0	3.108e-05	0	6.062e-05	rs367695544	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C19orf57	283	0	397	23	0.0547619047619048	TRUE	NA
ENSG00000068438.15	.	BCM	GRCh38.p13	chrX	48478513	48478513	+	G	G	A	Silent	SNP	ENST00000348411.3	exon3	c.G186A	p.K62K	exonic	ENSG00000068438.15	.	synonymous SNV	ENSG00000068438.15:ENST00000348411.3:exon3:c.G186A:p.K62K	Xp11.23	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FTSJ1	423	0	579	48	0.076555023923445	TRUE	TRUE
ENSG00000162980.17	.	BCM	GRCh38.p13	chr2	151810559	151810559	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000162980.17	.	.	.	2q23.3	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARL5A	54	0	84	6	0.0666666666666667	TRUE	NA
ENSG00000124224.17	.	BCM	GRCh38.p13	chr20	58239398	58239398	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000124224.17	.	.	.	20q13.32	C3L-03628	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPP4R1L	86	0	135	8	0.0559440559440559	TRUE	NA
ENSG00000198758.10	.	BCM	GRCh38.p13	chr1	109759287	109759287	+	G	G	A	Missense_Mutation	SNP	ENST00000361965.8	exon5	c.C356T	p.P119L	exonic	ENSG00000198758.10	.	nonsynonymous SNV	ENSG00000198758.10:ENST00000361965.8:exon5:c.C356T:p.P119L	1p13.3	C3N-03780	1.649e-05	0	0	0	0	1.501e-05	0	6.059e-05	rs757406657	2.20	D	T	B	B	N	N	L	T	D	0.214	T	T	T	0.021	0.350	0.391	0.088	T	T	T	T	T	T	1.334	14.630	0.577	N	N	-1.007	0.397	-0.978	0.516	0.990	0.428	0.547	0.547	0.613	.	5.240	2.290	0.730	-0.156	-0.135	0.040	0.025	0.006	567	Tensin/EPS8_phosphotyrosine-binding_domain;Epidermal_growth_factor_receptor_kinase_substrate,_phosphotyrosine-binding_domain	.	.	.	EPS8L3	221	0	333	23	0.0646067415730337	TRUE	NA
ENSG00000135835.12	.	BCM	GRCh38.p13	chr1	180935489	180935489	+	C	C	T	Missense_Mutation	SNP	ENST00000367588.9	exon5	c.C1580T	p.P527L	exonic	ENSG00000135835.12	.	nonsynonymous SNV	ENSG00000135835.12:ENST00000367588.9:exon5:c.C1580T:p.P527L	1q25.3	C3N-03780	0.0008	0	0	0	0	0.0013	0	0	rs371418964	2.20	T	D	B	B	N	N	N	T	D	0.123	T	T	T	0.011	.	0.055	0.216	T	T	T	T	T	T	0.597	7.480	0.966	N	N	-0.952	0.458	-1.024	0.460	1.000	0.616	0.618	0.535	0.605	.	4.620	-0.154	-0.489	0.019	0.452	0.000	0.000	0.001	865	.	.	.	ID=COSV62550999;OCCURENCE=1(ovary)	KIAA1614	21	0	36	8	0.181818181818182	TRUE	TRUE
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140322008	140322008	+	C	C	T	Missense_Mutation	SNP	ENST00000389484.8	exon82	c.G12595A	p.G4199R	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon82:c.G12595A:p.G4199R	2q22.1	C3N-03780	.	.	.	.	.	.	.	.	rs865839359	19.20	D	D	D	D	D	D	M	D	D	0.958	D	D	D	0.885	0.669	0.885	0.785	T	D	D	D	D	D	4.087	27.600	0.999	D	D	0.910	11.308	0.847	11.654	1.000	0.487	0.574	0.574	0.564	.	5.190	5.190	7.389	1.026	0.599	1.000	1.000	0.998	940	EGF-like_domain	.	.	ID=COSV67275984;OCCURENCE=1(skin)	LRP1B	235	1	351	34	0.0883116883116883	TRUE	TRUE
ENSG00000123607.15	.	BCM	GRCh38.p13	chr2	165913617	165913617	+	C	C	T	Missense_Mutation	SNP	ENST00000243344.8	exon16	c.G2168A	p.R723Q	exonic	ENSG00000123607.15	.	nonsynonymous SNV	ENSG00000123607.15:ENST00000243344.8:exon16:c.G2168A:p.R723Q	2q24.3	C3N-03780	7.483e-05	0	0.0007	0	0	0	0	6.091e-05	rs151309609	2.20	T	T	B	B	D	N	N	T	N	0.069	T	T	T	0.095	.	0.146	0.034	T	T	T	T	T	T	2.187	20.800	0.839	D	N	-1.177	0.243	-1.039	0.441	0.418	0.651	0.709	0.651	0.684	.	5.230	0.740	3.180	-0.258	-1.156	1.000	0.072	0.039	502	Tetratricopeptide_repeat-containing_domain	.	.	.	TTC21B	218	0	336	25	0.0692520775623269	TRUE	NA
ENSG00000138398.16	.	BCM	GRCh38.p13	chr2	169637078	169637078	+	G	G	A	Missense_Mutation	SNP	ENST00000260970.8	exon14	c.G1820A	p.R607Q	exonic	ENSG00000138398.16	.	nonsynonymous SNV	ENSG00000138398.16:ENST00000260970.8:exon14:c.G1820A:p.R607Q	2q31.1	C3N-03780	5.142e-05	0	0	0	0	0	0	0.0004	rs748608521	5.20	D	T	B	B	N	D	L	T	N	0.272	T	T	T	0.034	0.190	0.192	0.040	T	T	T	T	T	D	3.240	24.000	0.999	D	D	-0.305	1.601	-0.130	1.964	0.968	0.707	0.725	0.725	0.714	.	5.510	3.330	2.391	1.176	0.618	0.995	1.000	0.996	659	.	.	.	ID=COSV53646808;OCCURENCE=1(pancreas)	PPIG	213	0	319	31	0.0885714285714286	TRUE	TRUE
ENSG00000047315.17	.	BCM	GRCh38.p13	chr4	57023381	57023381	+	C	C	T	Missense_Mutation	SNP	ENST00000314595.6	exon19	c.C2567T	p.P856L	exonic	ENSG00000047315.17	.	nonsynonymous SNV	ENSG00000047315.17:ENST00000314595.6:exon19:c.C2567T:p.P856L	4q12	C3N-03780	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.767	D	D	D	0.699	0.681	0.781	2.568	D	D	D	D	D	D	4.253	29.200	0.999	D	D	0.917	11.493	0.880	12.909	1.000	0.707	0.725	0.725	0.617	.	5.520	5.520	7.726	1.026	0.599	1.000	0.994	0.998	909	DNA-directed_RNA_polymerase,_subunit_2,_hybrid-binding_domain	.	.	.	POLR2B	189	0	277	33	0.106451612903226	TRUE	TRUE
ENSG00000067248.10	.	BCM	GRCh38.p13	chr5	55270670	55270670	+	C	C	A	Missense_Mutation	SNP	ENST00000251636.10	exon19	c.G2901T	p.E967D	exonic	ENSG00000067248.10	.	nonsynonymous SNV	ENSG00000067248.10:ENST00000251636.10:exon19:c.G2901T:p.E967D	5q11.2	C3N-03780	.	.	.	.	.	.	.	.	.	9.20	T	D	D	D	D	D	L	T	N	0.796	T	T	T	0.187	0.389	0.488	0.813	D	T	T	T	D	D	3.238	24.000	0.997	D	N	0.269	3.622	0.236	3.362	0.001	0.707	0.654	0.725	0.714	.	5.440	2.550	1.891	1.026	0.549	1.000	0.179	0.826	480	Helicase,_C-terminal	.	.	.	DHX29	260	0	393	32	0.0752941176470588	TRUE	TRUE
ENSG00000204701.2	.	BCM	GRCh38.p13	chr6	29112314	29112314	+	C	C	T	Missense_Mutation	SNP	ENST00000641960.1	exon5	c.C424T	p.R142C	exonic	ENSG00000204701.2	.	nonsynonymous SNV	ENSG00000204701.2:ENST00000641960.1:exon5:c.C424T:p.R142C	6p22.1	C3N-03780	8.331e-06	0	0	0	0	1.509e-05	0	0	rs762835534	1.15	T	T	.	.	.	N	.	T	D	0.144	T	T	T	0.123	0.407	0.138	0.158	T	.	T	T	T	T	1.713	17.110	0.944	N	N	-0.778	0.688	-0.834	0.710	0.007	0.556	0.616	0.685	0.564	.	2.760	0.484	-3.183	-0.798	0.507	0.000	0.004	0.073	754	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV65848968;OCCURENCE=2(skin)	OR2J3	197	0	279	42	0.130841121495327	NA	TRUE
ENSG00000152822.14	.	BCM	GRCh38.p13	chr6	146399045	146399045	+	C	C	T	Missense_Mutation	SNP	ENST00000282753.6	exon7	c.C2006T	p.A669V	exonic	ENSG00000152822.14	.	nonsynonymous SNV	ENSG00000152822.14:ENST00000282753.6:exon7:c.C2006T:p.A669V	6q24.3	C3N-03780	.	.	.	.	.	.	.	.	.	17.20	D	D	D	P	D	D	L	D	D	0.776	D	D	D	0.826	0.680	0.919	1.689	T	D	D	D	D	D	3.535	24.800	0.999	D	D	0.565	5.585	0.622	6.510	0.975	0.487	0.574	0.547	0.564	.	5.510	5.510	6.170	1.026	0.549	1.000	0.999	0.991	287	GPCR_family_3,_C-terminal	.	.	ID=COSV51185332;OCCURENCE=1(large_intestine)	GRM1	117	0	174	12	0.0645161290322581	TRUE	TRUE
ENSG00000136205.17	.	BCM	GRCh38.p13	chr7	47400416	47400416	+	G	G	C	Missense_Mutation	SNP	ENST00000311160.14	exon15	c.C896G	p.S299C	exonic	ENSG00000136205.17	.	nonsynonymous SNV	ENSG00000136205.17:ENST00000311160.14:exon15:c.C896G:p.S299C	7p12.3	C3N-03780	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	N	D	M	T	D	0.647	T	T	D	0.449	0.804	0.552	.	T	D	D	D	D	D	4.180	28.500	0.993	D	D	0.960	12.707	0.899	13.698	1.000	0.732	0.688	0.710	0.728	.	5.290	5.290	9.303	1.176	0.676	1.000	0.953	0.978	906	Tensin_phosphatase,_C2_domain	.	.	.	TNS3	164	0	299	25	0.0771604938271605	TRUE	TRUE
ENSG00000164692.18	.	BCM	GRCh38.p13	chr7	94409409	94409409	+	G	G	A	Missense_Mutation	SNP	ENST00000297268.11	exon17	c.G880A	p.V294I	exonic	ENSG00000164692.18	.	nonsynonymous SNV	ENSG00000164692.18:ENST00000297268.11:exon17:c.G880A:p.V294I	7q21.3	C3N-03780	3.295e-05	0	8.639e-05	0.0001	0	0	0	0.0001	rs145693444	8.20	T	T	P	B	D	D	L	D	N	0.217	D	D	T	0.385	.	0.741	0.948	T	T	T	T	T	D	2.155	20.500	0.998	D	D	0.165	3.152	0.340	3.962	1.000	0.707	0.574	0.725	0.492	.	5.730	5.730	4.071	1.176	0.676	1.000	0.821	0.412	691	.	.	.	ID=COSV51967036;OCCURENCE=1(large_intestine),1(central_nervous_system)	COL1A2	551	0	681	61	0.0822102425876011	TRUE	TRUE
ENSG00000136960.12	.	BCM	GRCh38.p13	chr8	119619298	119619298	+	G	G	A	Missense_Mutation	SNP	ENST00000075322.10	exon5	c.C425T	p.S142L	exonic	ENSG00000136960.12	.	nonsynonymous SNV	ENSG00000136960.12:ENST00000075322.10:exon5:c.C425T:p.S142L	8q24.12	C3N-03780	0.0001	9.615e-05	0.0010	0	0	1.501e-05	0	6.062e-05	rs759807131	8.20	D	D	B	B	N	D	N	T	D	0.506	T	T	D	0.124	.	0.603	0.226	T	T	T	T	T	D	3.376	24.300	0.998	D	D	-0.064	2.292	0.102	2.742	1.000	0.615	0.624	0.659	0.621	.	5.490	5.490	6.338	1.176	0.618	1.000	0.846	0.878	910	Somatomedin_B_domain	.	.	.	ENPP2	148	0	274	19	0.0648464163822526	TRUE	NA
ENSG00000066827.16	.	BCM	GRCh38.p13	chr8	134509620	134509620	+	T	T	C	Missense_Mutation	SNP	ENST00000377838.8	exon15	c.A3491G	p.Q1164R	exonic	ENSG00000066827.16	.	nonsynonymous SNV	ENSG00000066827.16:ENST00000377838.8:exon15:c.A3491G:p.Q1164R	8q24.22	C3N-03780	.	.	.	.	.	.	.	.	rs750068172	11.20	D	D	D	D	D	D	L	T	D	0.640	T	T	T	0.225	0.279	0.455	0.917	T	T	D	T	D	T	4.473	32	0.998	D	D	0.324	3.904	0.359	4.079	1.000	0.672	0.702	0.653	0.621	.	5.920	5.920	6.085	1.138	0.665	1.000	0.565	0.717	964	.	.	.	.	ZFAT	247	0	370	58	0.135514018691589	TRUE	NA
ENSG00000165124.18	.	BCM	GRCh38.p13	chr9	110407081	110407081	+	G	G	T	Missense_Mutation	SNP	ENST00000374469.6	exon38	c.C8519A	p.A2840D	exonic	ENSG00000165124.18	.	nonsynonymous SNV	ENSG00000165124.18:ENST00000374469.6:exon38:c.C8519A:p.A2840D	9q31.3	C3N-03780	.	.	.	.	.	.	.	.	.	0.17	.	T	B	B	N	N	L	.	.	0.176	T	T	T	0.034	0.458	0.043	0.142	T	T	T	T	T	T	1.226	13.840	0.733	N	N	-0.309	1.591	-0.310	1.544	0.001	0.554	0.563	0.618	0.564	.	5.520	3.370	1.708	1.106	0.507	0.243	0.820	0.755	969	Sushi/SCR/CCP_domain	.	.	.	SVEP1	261	1	374	44	0.105263157894737	TRUE	NA
ENSG00000107951.14	.	BCM	GRCh38.p13	chr10	30336951	30336951	+	C	C	A	Missense_Mutation	SNP	ENST00000263063.8	exon4	c.G632T	p.C211F	exonic	ENSG00000107951.14	.	nonsynonymous SNV	ENSG00000107951.14:ENST00000263063.8:exon4:c.G632T:p.C211F	10p11.23	C3N-03780	.	.	.	.	.	.	.	.	.	12.20	D	D	B	B	D	D	M	T	D	0.933	T	T	T	0.239	0.429	0.419	1.409	T	T	D	D	D	D	3.167	23.800	0.982	D	D	0.244	3.502	0.282	3.613	0.302	0.732	0.725	0.744	0.714	.	5.640	4.720	4.527	1.026	0.594	1.000	0.992	0.967	917	.	.	.	.	MTPAP	535	0	682	43	0.0593103448275862	TRUE	TRUE
ENSG00000187122.17	.	BCM	GRCh38.p13	chr10	97013756	97013756	+	G	G	A	Missense_Mutation	SNP	ENST00000266058.9	exon30	c.C3188T	p.T1063I	exonic	ENSG00000187122.17	.	nonsynonymous SNV	ENSG00000187122.17:ENST00000266058.9:exon30:c.C3188T:p.T1063I	10q24.1	C3N-03780	.	.	.	.	.	.	.	.	rs1041420300	9.20	T	T	P	P	D	D	L	D	N	0.489	D	D	D	0.574	0.479	0.389	1.083	T	T	T	T	D	T	2.910	23.200	0.997	D	D	0.332	3.951	0.327	3.878	1.000	0.554	0.547	0.602	0.621	.	4.280	4.280	5.048	1.176	0.676	1.000	0.786	0.228	714	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	SLIT1	191	0	312	31	0.0903790087463557	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-03780	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	301	0	333	45	0.119047619047619	TRUE	TRUE
ENSG00000165972.13	.	BCM	GRCh38.p13	chr12	95878215	95878215	+	G	G	A	Missense_Mutation	SNP	ENST00000344280.8	exon13	c.C1274T	p.A425V	exonic	ENSG00000165972.13	.	nonsynonymous SNV	ENSG00000165972.13:ENST00000344280.8:exon13:c.C1274T:p.A425V	12q23.1	C3N-03780	4.154e-05	0	0.0003	0	0	3.021e-05	0	0	rs771269053	0.20	T	T	B	B	N	N	L	T	N	0.054	T	T	T	0.023	0.171	0.120	0.055	T	T	T	T	T	T	1.298	14.370	0.850	N	N	-0.432	1.314	-0.327	1.510	0.548	0.554	0.588	0.574	0.613	.	5.820	3.570	1.102	1.176	0.676	0.105	0.722	0.152	590	.	.	.	.	CCDC38	242	0	314	31	0.0898550724637681	TRUE	NA
ENSG00000100503.24	.	BCM	GRCh38.p13	chr14	50770906	50770906	+	G	G	A	Missense_Mutation	SNP	ENST00000382041.7	exon11	c.C1205T	p.S402L	exonic	ENSG00000100503.24	.	nonsynonymous SNV	ENSG00000100503.24:ENST00000382041.7:exon11:c.C1205T:p.S402L	14q22.1	C3N-03780	1.661e-05	0	0	0	0	1.506e-05	0	6.114e-05	rs768423014	12.20	D	D	D	D	D	D	M	T	D	0.454	T	T	T	0.149	0.274	0.451	0.193	T	T	T	T	D	D	3.991	26.900	0.999	D	D	0.709	7.254	0.681	7.412	1.000	0.707	0.702	0.725	0.714	.	5.510	5.510	5.399	1.176	0.676	1.000	0.940	0.901	433	.	.	.	ID=COSV55396464;OCCURENCE=1(large_intestine)	NIN	225	0	328	21	0.0601719197707736	TRUE	TRUE
ENSG00000179008.9	.	BCM	GRCh38.p13	chr14	60437031	60437031	+	C	C	A	Missense_Mutation	SNP	ENST00000321731.8	exon18	c.G1578T	p.K526N	exonic	ENSG00000179008.9	.	nonsynonymous SNV	ENSG00000179008.9:ENST00000321731.8:exon18:c.G1578T:p.K526N	14q23.1	C3N-03780	.	.	.	.	.	.	.	.	.	8.15	D	D	.	.	D	D	.	T	D	0.551	T	T	D	0.137	0.182	0.542	0.112	.	.	T	T	D	T	2.778	23.000	0.997	D	N	0.129	3.001	0.044	2.516	0.000	0.487	0.574	0.547	0.564	.	5.170	2.760	0.885	-0.170	-0.839	0.995	0.978	0.959	354	.	.	.	.	C14orf39	126	0	148	11	0.0691823899371069	TRUE	TRUE
ENSG00000154118.13	.	BCM	GRCh38.p13	chr16	87690426	87690426	+	G	G	A	Missense_Mutation	SNP	ENST00000284262.3	exon4	c.G2066A	p.R689Q	exonic	ENSG00000154118.13	.	nonsynonymous SNV	ENSG00000154118.13:ENST00000284262.3:exon4:c.G2066A:p.R689Q	16q24.2	C3N-03780	.	.	.	.	.	.	.	.	.	9.20	D	T	D	P	D	D	M	T	N	0.493	T	T	T	0.196	0.290	0.511	0.625	T	T	T	T	D	D	3.776	25.700	0.999	D	D	0.566	5.591	0.564	5.799	1.000	0.635	0.514	0.644	0.605	.	4.300	4.300	9.713	1.129	0.658	1.000	0.477	0.949	952	.	.	.	.	JPH3	48	0	62	5	0.0746268656716418	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675088	7675088	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G524A	p.R175H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G524A:p.R175H	17p13.1	C3N-03780	8.243e-06	0	0	0	0	1.499e-05	0	0	rs28934578	19.20	D	D	D	D	D	A	M	D	D	0.938	D	D	D	0.922	0.986	0.997	1.101	T	D	D	D	D	D	2.987	23.400	0.999	D	D	0.740	7.720	0.711	7.954	1.000	0.722	0.698	0.698	0.735	.	5.410	5.410	6.163	1.026	0.599	1.000	0.996	0.919	434	p53,_DNA-binding_domain	.	.	ID=COSV52661038;OCCURENCE=13(salivary_gland),172(breast),8(penis),1(peritoneum),14(liver),118(oesophagus),6(adrenal_gland),1(meninges),5(cervix),604(large_intestine),116(central_nervous_system),23(biliary_tract),94(ovary),9(vulva),2(pleura),5(bone),6(NS),124(stomach),74(haematopoietic_and_lymphoid_tissue),14(soft_tissue),21(kidney),38(urinary_tract),75(pancreas),10(skin),28(prostate),47(lung),14(thyroid),109(upper_aerodigestive_tract),1(testis),1(eye),3(small_intestine),31(endometrium)	TP53	371	1	401	30	0.0696055684454756	TRUE	TRUE
ENSG00000141376.22	.	BCM	GRCh38.p13	chr17	60684022	60684022	+	G	G	A	Missense_Mutation	SNP	ENST00000390652.9	exon3	c.G124A	p.D42N	exonic	ENSG00000141376.22	.	nonsynonymous SNV	ENSG00000141376.22:ENST00000390652.9:exon3:c.G124A:p.D42N	17q23.2	C3N-03780	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.648	T	T	T	0.225	0.362	0.581	1.154	D	T	T	T	D	D	4.217	28.800	0.999	D	D	0.767	8.169	0.791	9.872	1.000	0.707	0.670	0.659	0.714	.	6.080	6.080	7.140	1.176	0.676	1.000	1.000	0.998	459	.	.	.	.	BCAS3	121	0	204	20	0.0892857142857143	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51078380	51078380	+	G	G	T	Missense_Mutation	SNP	ENST00000342988.8	exon12	c.G1572T	p.W524C	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon12:c.G1572T:p.W524C	18q21.2	C3N-03780	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.978	D	D	D	0.933	0.933	0.993	3.877	D	D	D	D	D	D	4.570	32	0.990	D	D	1.104	17.701	1.054	22.670	1.000	0.707	0.725	0.725	0.714	.	6.080	6.080	9.830	1.176	0.676	1.000	1.000	0.998	860	SMAD_domain,_Dwarfin-type	.	.	ID=COSV61686227;OCCURENCE=4(large_intestine),3(pancreas)	SMAD4	317	0	435	37	0.0783898305084746	TRUE	TRUE
ENSG00000130589.16	.	BCM	GRCh38.p13	chr20	63561610	63561610	+	T	T	C	Missense_Mutation	SNP	ENST00000467148.1	exon12	c.A6827G	p.Q2276R	exonic	ENSG00000130589.16	.	nonsynonymous SNV	ENSG00000130589.16:ENST00000467148.1:exon12:c.A6827G:p.Q2276R	20q13.33	C3N-03780	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	D	N	0.083	T	T	D	0.101	0.278	0.237	0.203	T	T	T	T	T	T	0.338	4.723	0.626	N	N	-1.415	0.111	-1.435	0.135	0.079	0.660	0.694	0.723	0.636	.	4.490	-1.200	-0.802	-0.278	-0.242	0.000	0.001	0.024	.	.	.	.	.	HELZ2	65	0	103	9	0.0803571428571429	TRUE	TRUE
ENSG00000100285.10	.	BCM	GRCh38.p13	chr22	29480902	29480902	+	G	G	A	Missense_Mutation	SNP	ENST00000310624.7	exon1	c.G640A	p.V214M	exonic	ENSG00000100285.10	.	nonsynonymous SNV	ENSG00000100285.10:ENST00000310624.7:exon1:c.G640A:p.V214M	22q12.2	C3N-03780	.	.	.	.	.	.	.	.	.	6.15	D	T	.	.	N	N	.	D	N	0.076	T	D	D	0.163	0.482	0.796	1.092	D	.	T	T	T	.	2.131	20.300	0.957	D	N	-0.632	0.931	-0.620	1.016	1.000	0.598	0.479	0.504	0.639	.	4.080	3.040	1.486	1.082	0.520	0.005	0.997	0.486	677	.	.	.	.	NEFH	210	0	280	31	0.0996784565916399	TRUE	NA
ENSG00000165694.9	.	BCM	GRCh38.p13	chrX	132078665	132078665	+	T	T	G	Missense_Mutation	SNP	ENST00000298542.8	exon12	c.A1352C	p.K451T	exonic	ENSG00000165694.9	.	nonsynonymous SNV	ENSG00000165694.9:ENST00000298542.8:exon12:c.A1352C:p.K451T	Xq26.2	C3N-03780	.	.	.	.	.	.	.	.	.	6.19	D	T	P	P	N	N	M	D	N	0.106	T	D	D	0.282	0.379	0.820	0.291	T	T	T	T	T	T	1.529	15.920	0.995	D	.	.	.	.	.	0.990	.	.	.	.	.	5.760	0.636	0.753	1.138	0.665	0.990	0.873	0.866	276	.	.	.	.	FRMD7	150	0	225	16	0.0663900414937759	TRUE	TRUE
ENSG00000067842.17	.	BCM	GRCh38.p13	chrX	153536428	153536428	+	C	C	T	Missense_Mutation	SNP	ENST00000263519.4	exon1	c.C181T	p.R61W	exonic	ENSG00000067842.17	.	nonsynonymous SNV	ENSG00000067842.17:ENST00000263519.4:exon1:c.C181T:p.R61W	Xq28	C3N-03780	.	.	.	.	.	.	.	.	rs895866699	11.19	D	D	D	P	D	N	M	T	D	0.325	D	D	D	0.501	0.446	0.898	1.409	T	T	T	T	D	D	1.831	17.960	0.997	N	.	.	.	.	.	1.000	.	.	.	.	.	5.790	-4.150	0.327	-0.163	-0.140	0.008	0.974	0.914	116	Cation-transporting_P-type_ATPase,_N-terminal	.	.	.	ATP2B3	289	1	356	33	0.0848329048843188	TRUE	NA
ENSG00000169231.13	.	BCM	GRCh38.p13	chr1	155197660	155197660	+	C	C	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000169231.13	ENST00000368378.7:exon20:c.2303-1G>C	.	.	1q22	C3N-03780	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.135	33	0.994	D	.	1.115	18.193	0.943	15.742	1.000	0.361	0.346	0.151	0.221	0.989	4.740	4.740	7.857	1.026	0.549	1.000	0.947	0.925	69	.	.	.	.	THBS3	72	1	102	12	0.105263157894737	TRUE	NA
ENSG00000284770.2	.	BCM	GRCh38.p13	chr1	235434281	235434281	+	G	G	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000284770.2;ENSG00000285053.1	ENST00000642610.2:exon8:c.737+1G>C;ENST00000645655.1:exon11:c.737+1G>C	.	.	1q42.3	C3N-03780	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.258	33	0.991	D	.	0.969	12.973	0.781	9.575	1.000	0.295	0.304	0.217	0.196	0.973	5.550	5.550	6.588	1.130	0.676	1.000	0.984	0.390	356	.	.	.	.	TBCE	352	0	470	25	0.0505050505050505	NA	TRUE
ENSG00000169994.18	.	BCM	GRCh38.p13	chr2	127609593	127609593	+	C	C	T	Silent	SNP	ENST00000428314.5	exon23	c.C2902T	p.L968L	exonic	ENSG00000169994.18	.	synonymous SNV	ENSG00000169994.18:ENST00000428314.5:exon23:c.C2902T:p.L968L	2q14.3	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO7B	416	0	507	47	0.0848375451263538	TRUE	TRUE
ENSG00000128714.6	.	BCM	GRCh38.p13	chr2	176093028	176093028	+	G	G	A	Silent	SNP	ENST00000392539.4	exon1	c.G138A	p.A46A	exonic	ENSG00000128714.6	.	synonymous SNV	ENSG00000128714.6:ENST00000392539.4:exon1:c.G138A:p.A46A	2q31.1	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HOXD13	94	0	190	12	0.0594059405940594	TRUE	TRUE
ENSG00000055955.17	.	BCM	GRCh38.p13	chr3	52825976	52825976	+	T	T	C	Silent	SNP	ENST00000266041.9	exon6	c.A669G	p.Q223Q	exonic	ENSG00000055955.17	.	synonymous SNV	ENSG00000055955.17:ENST00000266041.9:exon6:c.A669G:p.Q223Q	3p21.1	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITIH4	137	0	231	17	0.0685483870967742	TRUE	TRUE
ENSG00000150625.16	.	BCM	GRCh38.p13	chr4	175701715	175701715	+	C	C	T	Silent	SNP	ENST00000280187.11	exon3	c.G90A	p.L30L	exonic	ENSG00000150625.16	.	synonymous SNV	ENSG00000150625.16:ENST00000280187.11:exon3:c.G90A:p.L30L	4q34.2	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54548561;OCCURENCE=1(large_intestine)	GPM6A	229	0	322	18	0.0529411764705882	TRUE	TRUE
ENSG00000113763.12	.	BCM	GRCh38.p13	chr5	176868661	176868661	+	C	C	T	Silent	SNP	ENST00000329542.9	exon4	c.C537T	p.A179A	exonic	ENSG00000113763.12	.	synonymous SNV	ENSG00000113763.12:ENST00000329542.9:exon4:c.C537T:p.A179A	5q35.2	C3N-03780	2.697e-05	0	0	0	0	4.865e-05	0	0	rs373056438	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56169754;OCCURENCE=1(large_intestine)	UNC5A	98	0	180	12	0.0625	TRUE	TRUE
ENSG00000104517.13	.	BCM	GRCh38.p13	chr8	102304138	102304138	+	T	T	C	Silent	SNP	ENST00000520539.6	exon22	c.A2859G	p.A953A	exonic	ENSG00000104517.13	.	synonymous SNV	ENSG00000104517.13:ENST00000520539.6:exon22:c.A2859G:p.A953A	8q22.3	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBR5	157	0	260	37	0.124579124579125	TRUE	TRUE
ENSG00000165806.21	.	BCM	GRCh38.p13	chr10	113725525	113725525	+	C	C	G	Silent	SNP	ENST00000369318.8	exon5	c.C540G	p.L180L	exonic	ENSG00000165806.21	.	synonymous SNV	ENSG00000165806.21:ENST00000369318.8:exon5:c.C540G:p.L180L	10q25.3	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CASP7	63	0	78	5	0.0602409638554217	NA	TRUE
ENSG00000197790.1	.	BCM	GRCh38.p13	chr11	4545268	4545268	+	C	C	T	Silent	SNP	ENST00000360213.1	exon1	c.C78T	p.H26H	exonic	ENSG00000197790.1	.	synonymous SNV	ENSG00000197790.1:ENST00000360213.1:exon1:c.C78T:p.H26H	11p15.4	C3N-03780	8.262e-06	0	0	0	0	1.502e-05	0	0	rs559376682	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64171853;OCCURENCE=2(lung),2(upper_aerodigestive_tract)	OR52M1	113	0	218	18	0.076271186440678	NA	TRUE
ENSG00000121741.16	.	BCM	GRCh38.p13	chr13	20062940	20062940	+	A	A	G	Silent	SNP	ENST00000610343.4	exon18	c.A3006G	p.P1002P	exonic	ENSG00000121741.16	.	synonymous SNV	ENSG00000121741.16:ENST00000610343.4:exon18:c.A3006G:p.P1002P	13q12.11	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZMYM2	92	0	140	9	0.0604026845637584	TRUE	TRUE
ENSG00000254585.5	.	BCM	GRCh38.p13	chr15	23646978	23646978	+	C	C	T	Silent	SNP	ENST00000650528.1	exon1	c.G765A	p.P255P	exonic	ENSG00000254585.5	.	synonymous SNV	ENSG00000254585.5:ENST00000650528.1:exon1:c.G765A:p.P255P	15q11.2	C3N-03780	6.34e-05	0	0	0	0	0.0002	0	0	rs760536434	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAGEL2	200	0	329	29	0.0810055865921788	TRUE	NA
ENSG00000130300.9	.	BCM	GRCh38.p13	chr19	17377196	17377196	+	G	G	A	Silent	SNP	ENST00000252590.9	exon1	c.C93T	p.F31F	exonic	ENSG00000130300.9	.	synonymous SNV	ENSG00000130300.9:ENST00000252590.9:exon1:c.C93T:p.F31F	19p13.11	C3N-03780	0.0002	0	0.0010	0.0010	0	0	0	6.056e-05	rs202209497	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53083849;OCCURENCE=2(skin)	PLVAP	303	0	411	52	0.11231101511879	TRUE	TRUE
ENSG00000064042.18	.	BCM	GRCh38.p13	chr4	41632843	41632843	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000064042.18	.	.	.	4p13	C3N-03780	.	.	.	.	.	.	.	.	rs1055359702	2.19	T	D	B	B	N	N	.	T	N	0.125	T	T	D	0.025	0.272	0.068	.	T	T	T	T	T	T	0.002	1.348	0.990	N	N	-0.849	0.587	-0.908	0.609	1.000	0.497	0.563	0.547	0.542	.	5.030	1.120	-0.335	-0.211	-0.186	0.000	0.003	0.006	845	.	.	.	.	LIMCH1	339	0	513	45	0.0806451612903226	TRUE	NA
ENSG00000254469.7	.	BCM	GRCh38.p13	chr11	71916181	71916181	+	G	G	A	3'Flank	SNP	NA	NA	NA	NA	downstream	ENSG00000254469.7	dist=414	.	.	11q13.4	C3N-03780	0.0002	0	0	0	0	0	0	0.0003	rs766087889	4.12	D	D	.	.	.	.	.	T	D	.	T	T	.	0.182	0.569	0.504	.	.	.	T	T	D	T	2.433	22.200	0.999	N	N	0.042	2.665	0.028	2.458	0.028	0.651	0.654	0.651	0.636	.	5.850	4.940	0.916	0.214	0.676	0.006	0.897	0.832	654	.	.	.	.	AP002495.1	314	0	388	34	0.0805687203791469	TRUE	NA
ENSG00000255087.4	.	BCM	GRCh38.p13	chr11	127099363	127099363	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000255087.4	.	.	.	11q24.2	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AP001993.1	180	0	297	22	0.0689655172413793	TRUE	NA
ENSG00000205325.3	.	BCM	GRCh38.p13	chr17	14780042	14780042	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000205325.3	.	.	.	17p12	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC005863.1	245	0	319	26	0.0753623188405797	TRUE	NA
ENSG00000065559.15	.	BCM	GRCh38.p13	chr17	12095663	12095664	+	TT	TT	AA	Unknown	MNP	ENST00000353533.10	exon4	c.482_483delinsAA	p.I161K	exonic	ENSG00000065559.15	.	nonframeshift substitution	ENSG00000065559.15:ENST00000353533.10:exon4:c.482_483delinsAA:p.I161K	17p12	C3N-03780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP2K4	162	20	249	20	0.0743494423791822	TRUE	TRUE
ENSG00000127463.15	.	BCM	GRCh38.p13	chr1	19240328	19240328	+	G	G	A	Missense_Mutation	SNP	ENST00000477853.6	exon7	c.C755T	p.T252M	exonic	ENSG00000127463.15	.	nonsynonymous SNV	ENSG00000127463.15:ENST00000477853.6:exon7:c.C755T:p.T252M	1p36.13	C3L-01637	8.24e-06	0	0	0	0	1.499e-05	0	0	rs558157154	5.20	D	T	D	P	N	D	L	T	N	0.260	T	T	T	0.115	.	0.620	0.382	T	T	T	T	T	D	3.526	24.800	0.997	D	N	0.455	4.702	0.514	5.291	1.000	0.719	0.723	0.725	0.714	.	5.770	5.770	2.748	1.176	0.676	0.999	0.884	0.979	778	.	.	.	.	EMC1	134	0	278	55	0.165165165165165	TRUE	NA
ENSG00000243710.7	.	BCM	GRCh38.p13	chr1	43185291	43185291	+	G	G	C	Missense_Mutation	SNP	ENST00000372492.8	exon5	c.G904C	p.G302R	exonic	ENSG00000243710.7	.	nonsynonymous SNV	ENSG00000243710.7:ENST00000372492.8:exon5:c.G904C:p.G302R	1p34.2	C3L-01637	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	.	T	D	0.909	T	T	D	0.512	0.547	0.360	0.708	T	T	D	D	D	D	4.167	28.300	0.999	D	D	0.882	10.591	0.860	12.156	1.000	0.534	0.547	0.686	0.621	.	5.530	5.530	8.695	1.176	0.618	1.000	0.994	0.991	467	.	.	.	.	CFAP57	506	0	838	146	0.148373983739837	TRUE	TRUE
ENSG00000153187.20	.	BCM	GRCh38.p13	chr1	244863639	244863639	+	-	NA	CCGCCGCCT	In_Frame_Ins	INS	ENST00000640218.2	exon1	c.668_669insAGGCGGCGG	p.G223_R224insGGG	exonic	ENSG00000153187.20	.	nonframeshift insertion	ENSG00000153187.20:ENST00000640218.2:exon1:c.668_669insAGGCGGCGG:p.G223_R224insGGG	1q44	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HNRNPU	NA	NA	NA	NA	NA	NA	NA
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178774411	178774411	+	C	C	A	Nonsense_Mutation	SNP	ENST00000591111.5	exon30	c.G6853T	p.E2285X	exonic	ENSG00000155657.27	.	stopgain	ENSG00000155657.27:ENST00000591111.5:exon30:c.G6853T:p.E2285X	2q31.2	C3L-01637	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	.	A	.	.	.	0.983	.	.	.	.	.	.	.	.	.	D	D	.	.	7.208	37	0.996	D	N	1.191	22.918	1.052	22.509	1.000	0.516	0.602	0.574	0.586	.	5.600	5.600	7.905	1.026	0.599	1.000	1.000	0.995	343	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	TTN	210	0	426	57	0.118012422360248	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178784339	178784339	+	C	C	T	Missense_Mutation	SNP	ENST00000591111.5	exon16	c.G2506A	p.G836S	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon16:c.G2506A:p.G836S	2q31.2	C3L-01637	5.005e-05	0	8.663e-05	0.0001	0	4.563e-05	0	6.061e-05	rs751157908	14.17	D	D	D	D	.	D	.	D	D	0.709	D	D	D	0.462	0.315	0.587	0.387	T	.	T	T	D	D	3.312	24.200	0.977	D	D	0.696	7.064	0.722	8.183	1.000	0.497	0.547	0.547	0.542	.	5.520	5.520	7.512	1.026	0.599	1.000	0.999	0.992	363	.	.	.	ID=COSV60007599;OCCURENCE=1(salivary_gland),1(biliary_tract),1(lung)	TTN	224	1	467	64	0.120527306967985	TRUE	NA
ENSG00000144406.19	.	BCM	GRCh38.p13	chr2	209820375	209820375	+	C	C	T	Missense_Mutation	SNP	ENST00000439458.5	exon13	c.C2027T	p.A676V	exonic	ENSG00000144406.19	.	nonsynonymous SNV	ENSG00000144406.19:ENST00000439458.5:exon13:c.C2027T:p.A676V	2q34	C3L-01637	4.475e-05	0	0	0	0	0	0	0.0001	rs768146438	7.19	T	D	P	B	.	N	L	T	N	0.505	T	T	D	0.426	0.649	0.530	0.912	D	T	T	T	D	D	1.439	15.340	0.997	D	D	0.182	3.224	0.282	3.615	0.996	0.487	0.574	0.547	0.564	.	5.740	5.740	6.044	1.026	0.549	1.000	0.578	0.175	814	.	.	.	.	UNC80	128	0	224	40	0.151515151515152	TRUE	NA
ENSG00000114487.10	.	BCM	GRCh38.p13	chr3	109118040	109118040	+	G	G	A	Missense_Mutation	SNP	ENST00000232603.10	exon1	c.C20T	p.A7V	exonic	ENSG00000114487.10	.	nonsynonymous SNV	ENSG00000114487.10:ENST00000232603.10:exon1:c.C20T:p.A7V	3q13.13	C3L-01637	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.126	T	T	T	0.016	0.292	0.302	0.174	T	T	T	T	T	T	0.328	4.615	0.967	N	N	-1.349	0.139	-1.368	0.168	0.012	0.526	0.574	0.616	0.564	.	4.860	-2.210	-0.197	-1.107	-0.127	0.000	0.000	0.001	898	.	.	.	ID=COSV51730439;OCCURENCE=1(large_intestine)	MORC1	137	0	342	40	0.104712041884817	TRUE	TRUE
ENSG00000155890.4	.	BCM	GRCh38.p13	chr3	140678504	140678504	+	A	A	T	Missense_Mutation	SNP	ENST00000286349.4	exon1	c.A275T	p.E92V	exonic	ENSG00000155890.4	.	nonsynonymous SNV	ENSG00000155890.4:ENST00000286349.4:exon1:c.A275T:p.E92V	3q23	C3L-01637	.	.	.	.	.	.	.	.	.	5.20	D	D	P	P	N	D	L	T	N	0.725	T	T	T	0.078	0.369	0.443	0.843	T	T	T	T	D	T	3.567	24.900	0.993	D	N	0.209	3.344	0.297	3.701	0.024	0.487	0.590	0.574	0.564	.	5.150	5.150	2.733	1.312	0.756	1.000	0.995	0.974	564	.	.	.	.	TRIM42	208	0	417	69	0.141975308641975	TRUE	TRUE
ENSG00000109606.13	.	BCM	GRCh38.p13	chr4	24556271	24556271	+	T	T	C	Missense_Mutation	SNP	ENST00000336812.5	exon4	c.A841G	p.R281G	exonic	ENSG00000109606.13	.	nonsynonymous SNV	ENSG00000109606.13:ENST00000336812.5:exon4:c.A841G:p.R281G	4p15.2	C3L-01637	.	.	.	.	.	.	.	.	.	9.20	T	T	B	B	D	D	L	T	D	0.737	T	T	D	0.235	0.532	0.789	2.313	D	T	T	T	D	D	3.064	23.500	0.992	D	D	0.211	3.352	0.390	4.287	1.000	0.707	0.725	0.702	0.714	.	6.170	6.170	6.152	1.138	0.665	1.000	1.000	1.000	515	Helicase_superfamily_1/2,_ATP-binding_domain;DEAD/DEAH_box_helicase_domain	.	.	.	DHX15	115	0	190	34	0.151785714285714	TRUE	TRUE
ENSG00000163453.11	.	BCM	GRCh38.p13	chr4	57110114	57110114	+	-	NA	C	Frame_Shift_Ins	INS	ENST00000295666.6	exon1	c.237dupG	p.Y80Vfs*18	exonic	ENSG00000163453.11	.	frameshift insertion	ENSG00000163453.11:ENST00000295666.6:exon1:c.237dupG:p.Y80Vfs*18	4q12	C3L-01637	.	.	.	.	.	.	.	.	rs969745457	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGFBP7	NA	NA	NA	NA	NA	NA	NA
ENSG00000156269.5	.	BCM	GRCh38.p13	chr4	79325343	79325343	+	C	C	T	Missense_Mutation	SNP	ENST00000286794.5	exon1	c.G535A	p.E179K	exonic	ENSG00000156269.5	.	nonsynonymous SNV	ENSG00000156269.5:ENST00000286794.5:exon1:c.G535A:p.E179K	4q21.21	C3L-01637	8.329e-06	0	0	0.0001	0	0	0	0	rs772384949	1.20	T	T	P	B	U	N	M	T	N	0.119	T	T	T	0.056	0.297	0.266	0.196	T	T	T	T	T	T	1.685	16.920	0.989	N	N	-0.419	1.343	-0.515	1.179	1.000	0.487	0.574	0.574	0.564	.	4.890	3.090	1.008	1.000	0.599	0.016	0.462	0.033	531	.	.	.	.	NAA11	232	0	523	78	0.129783693843594	TRUE	NA
ENSG00000079841.18	.	BCM	GRCh38.p13	chr6	72400515	72400515	+	A	A	G	Missense_Mutation	SNP	ENST00000521978.5	exon34	c.A4880G	p.Y1627C	exonic	ENSG00000079841.18	.	nonsynonymous SNV	ENSG00000079841.18:ENST00000521978.5:exon34:c.A4880G:p.Y1627C	6q13	C3L-01637	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.906	D	D	D	0.841	0.718	0.892	1.965	D	D	D	D	D	D	4.472	32	0.997	D	D	0.973	13.106	0.889	13.287	1.000	0.554	0.563	0.618	0.621	.	5.210	5.210	9.321	1.312	0.756	1.000	1.000	0.998	883	C2_domain	.	.	.	RIMS1	188	0	345	71	0.170673076923077	TRUE	NA
ENSG00000179869.15	.	BCM	GRCh38.p13	chr7	48524381	48524381	+	C	C	T	Missense_Mutation	SNP	ENST00000435803.6	exon54	c.C14185T	p.R4729C	exonic	ENSG00000179869.15	.	nonsynonymous SNV	ENSG00000179869.15:ENST00000435803.6:exon54:c.C14185T:p.R4729C	7p12.3	C3L-01637	0.0004	0.0002	8.954e-05	0	0	0.0004	0.0011	0.0007	rs185678311	6.16	D	D	.	.	N	N	.	D	N	0.319	D	D	D	0.417	.	0.458	0.101	T	.	T	T	T	T	1.021	11.880	0.932	N	N	-0.912	0.505	-1.195	0.287	0.930	0.487	0.574	0.574	0.564	.	5.590	-9.240	-1.128	0.234	-0.136	0.000	0.005	0.121	806	ABC_transporter-like	.	.	.	ABCA13	252	0	475	55	0.10377358490566	TRUE	NA
ENSG00000221866.9	.	BCM	GRCh38.p13	chr7	132181502	132181502	+	T	T	C	Missense_Mutation	SNP	ENST00000359827.7	exon18	c.A3371G	p.N1124S	exonic	ENSG00000221866.9	.	nonsynonymous SNV	ENSG00000221866.9:ENST00000359827.7:exon18:c.A3371G:p.N1124S	7q32.3	C3L-01637	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	D	D	M	T	D	0.537	T	T	D	0.311	0.655	0.729	1.130	T	D	T	T	D	D	3.711	25.500	0.999	D	D	0.653	6.507	0.622	6.515	1.000	0.563	0.574	0.602	0.636	.	5.250	5.250	6.081	1.138	0.665	1.000	0.969	0.916	933	IPT_domain	.	.	.	PLXNA4	447	2	889	192	0.177613320999075	TRUE	TRUE
ENSG00000180190.11	.	BCM	GRCh38.p13	chr8	492475	492475	+	-	NA	GCA	In_Frame_Ins	INS	ENST00000613071.1	exon4	c.481_482insTGC	p.L160_R161insL	exonic	ENSG00000180190.11	.	nonframeshift insertion	ENSG00000180190.11:ENST00000613071.1:exon4:c.481_482insTGC:p.L160_R161insL	8p23.3	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TDRP	NA	NA	NA	NA	NA	NA	NA
ENSG00000158941.16	.	BCM	GRCh38.p13	chr8	22608031	22608031	+	C	C	T	Missense_Mutation	SNP	ENST00000308511.8	exon7	c.C550T	p.R184W	exonic	ENSG00000158941.16	.	nonsynonymous SNV	ENSG00000158941.16:ENST00000308511.8:exon7:c.C550T:p.R184W	8p21.3	C3L-01637	2.479e-05	0	0	0.0001	0	1.504e-05	0	6.069e-05	rs376168583	13.20	D	D	D	D	D	D	L	T	D	0.562	T	T	D	0.317	0.598	0.565	2.149	T	T	T	D	D	D	4.056	27.400	0.999	D	D	0.475	4.847	0.490	5.072	1.000	0.722	0.699	0.725	0.711	.	5.820	4.920	2.710	1.026	0.599	1.000	0.999	0.997	885	.	.	.	ID=COSV51514431;OCCURENCE=2(large_intestine)	CCAR2	219	1	381	57	0.13013698630137	TRUE	TRUE
ENSG00000234616.9	.	BCM	GRCh38.p13	chr8	142664977	142665003	+	TCGTTCATGTTGTAGCGGGCGTGGGGG	TCGTTCATGTTGTAGCGGGCGTGGGGG	-	In_Frame_Del	DEL	ENST00000615982.4	exon2	c.1056_1082del	p.P353_D361del	exonic	ENSG00000234616.9	.	nonframeshift deletion	ENSG00000234616.9:ENST00000615982.4:exon2:c.1056_1082del:p.P353_D361del	8q24.3	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	JRK	153	0	302	37	0.109144542772861	TRUE	NA
ENSG00000057608.17	.	BCM	GRCh38.p13	chr10	5773884	5773884	+	A	A	-	Frame_Shift_Del	DEL	ENST00000380191.9	exon7	c.777delT	p.I259Mfs*7	exonic	ENSG00000057608.17	.	frameshift deletion	ENSG00000057608.17:ENST00000380191.9:exon7:c.777delT:p.I259Mfs*7	10p15.1	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GDI2	206	0	303	40	0.116618075801749	TRUE	TRUE
ENSG00000204740.11	.	BCM	GRCh38.p13	chr10	19331562	19331562	+	A	A	T	Missense_Mutation	SNP	ENST00000454679.7	exon24	c.A3881T	p.D1294V	exonic	ENSG00000204740.11	.	nonsynonymous SNV	ENSG00000204740.11:ENST00000454679.7:exon24:c.A3881T:p.D1294V	10p12.31	C3L-01637	.	.	.	.	.	.	.	.	.	14.14	D	D	.	.	.	D	.	D	D	0.847	D	D	D	0.887	.	0.869	.	.	.	D	D	D	D	4.287	29.500	0.994	D	D	0.456	4.709	0.552	5.667	1.000	0.487	0.574	0.574	0.564	.	5.930	5.930	8.505	1.284	0.750	1.000	0.994	0.969	950	Low-density_lipoprotein_(LDL)_receptor_class_A,_conserved_site	.	.	.	MALRD1	169	1	305	58	0.159779614325069	TRUE	TRUE
ENSG00000138316.11	.	BCM	GRCh38.p13	chr10	70730156	70730156	+	C	C	T	Missense_Mutation	SNP	ENST00000373207.2	exon6	c.C1009T	p.R337C	exonic	ENSG00000138316.11	.	nonsynonymous SNV	ENSG00000138316.11:ENST00000373207.2:exon6:c.C1009T:p.R337C	10q22.1	C3L-01637	1.655e-05	0	0	0.0001	0	1.506e-05	0	0	rs775055593	17.20	D	D	D	D	D	D	M	T	D	0.884	D	T	D	0.480	0.536	0.881	0.815	D	T	D	D	D	D	4.367	31	0.999	D	D	0.801	8.795	0.741	8.599	1.000	0.539	0.574	0.784	0.564	.	4.700	4.700	5.978	0.947	0.599	1.000	1.000	0.998	324	Peptidase_M12B,_ADAM/reprolysin	.	.	ID=COSV100941798;OCCURENCE=1(pancreas)	ADAMTS14	102	0	217	41	0.158914728682171	TRUE	NA
ENSG00000182170.3	.	BCM	GRCh38.p13	chr11	3217955	3217955	+	C	C	A	Missense_Mutation	SNP	ENST00000332314.3	exon1	c.G859T	p.G287C	exonic	ENSG00000182170.3	.	nonsynonymous SNV	ENSG00000182170.3:ENST00000332314.3:exon1:c.G859T:p.G287C	11p15.4	C3L-01637	.	.	.	.	.	.	.	.	.	5.17	D	D	.	.	.	N	M	T	D	0.168	T	T	T	0.014	0.308	0.067	.	T	T	T	T	D	T	1.570	16.190	0.983	N	N	-0.948	0.462	-1.111	0.365	0.997	0.487	0.574	0.578	0.563	.	3.720	-3.470	-1.145	-0.978	0.577	0.000	0.020	0.023	976	.	.	.	.	MRGPRG	47	0	82	14	0.145833333333333	TRUE	TRUE
ENSG00000170790.5	.	BCM	GRCh38.p13	chr11	6869861	6869861	+	C	C	A	Missense_Mutation	SNP	ENST00000641461.1	exon2	c.C107A	p.T36N	exonic	ENSG00000170790.5	.	nonsynonymous SNV	ENSG00000170790.5:ENST00000641461.1:exon2:c.C107A:p.T36N	11p15.4	C3L-01637	.	.	.	.	.	.	.	.	.	7.20	D	D	D	P	D	N	M	T	D	0.472	T	T	T	0.082	0.579	0.602	0.414	T	T	T	T	D	T	1.964	18.980	0.980	N	N	0.134	3.025	-0.054	2.183	0.006	0.554	0.574	0.618	0.564	.	4.300	4.300	0.901	1.023	0.599	0.000	0.050	0.017	522	GPCR,_rhodopsin-like,_7TM	.	.	.	OR10A2	319	1	676	105	0.134443021766965	NA	TRUE
ENSG00000234776.5	.	BCM	GRCh38.p13	chr11	45907191	45907191	+	G	G	-	Frame_Shift_Del	DEL	ENST00000449465.2	exon1	c.55delC	p.L19Sfs*15	exonic	ENSG00000234776.5	.	frameshift deletion	ENSG00000234776.5:ENST00000449465.2:exon1:c.55delC:p.L19Sfs*15	11p11.2	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C11orf94	172	0	394	70	0.150862068965517	TRUE	TRUE
ENSG00000149357.10	.	BCM	GRCh38.p13	chr11	72099151	72099151	+	C	C	T	Missense_Mutation	SNP	ENST00000278671.10	exon2	c.G148A	p.E50K	exonic	ENSG00000149357.10	.	nonsynonymous SNV	ENSG00000149357.10:ENST00000278671.10:exon2:c.G148A:p.E50K	11q13.4	C3L-01637	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.935	T	T	D	0.381	0.209	0.804	1.225	D	D	D	D	D	D	4.112	27.900	0.983	D	D	0.637	6.321	0.703	7.804	1.000	0.707	0.702	0.702	0.714	.	5.910	5.910	7.326	1.010	0.580	1.000	1.000	0.996	557	.	.	.	.	LAMTOR1	126	1	317	39	0.109550561797753	TRUE	TRUE
ENSG00000134640.2	.	BCM	GRCh38.p13	chr11	92969828	92969828	+	C	C	T	Nonsense_Mutation	SNP	ENST00000257068.2	exon1	c.C103T	p.R35X	exonic	ENSG00000134640.2	.	stopgain	ENSG00000134640.2:ENST00000257068.2:exon1:c.C103T:p.R35X	11q14.3	C3L-01637	.	.	.	.	.	.	.	.	rs551192907	4.6	.	.	.	.	D	A	.	.	.	0.596	.	.	.	.	.	.	.	.	.	D	D	.	.	4.999	33	0.992	N	N	-0.013	2.465	-0.370	1.427	0.997	0.549	0.627	0.608	0.530	.	3.500	2.540	0.398	0.012	0.596	0.008	0.000	0.001	803	.	.	.	.	MTNR1B	75	0	212	19	0.0822510822510823	TRUE	NA
ENSG00000137692.12	.	BCM	GRCh38.p13	chr11	103089299	103089299	+	G	G	A	Missense_Mutation	SNP	ENST00000260247.10	exon2	c.C106T	p.P36S	exonic	ENSG00000137692.12	.	nonsynonymous SNV	ENSG00000137692.12:ENST00000260247.10:exon2:c.C106T:p.P36S	11q22.3	C3L-01637	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	D	N	.	N	0.079	T	T	T	0.120	0.173	0.246	0.724	T	T	T	T	T	T	1.837	18.010	0.899	D	N	-0.536	1.106	-0.267	1.633	1.000	0.660	0.663	0.663	0.639	.	5.800	3.940	1.782	1.176	0.676	1.000	1.000	1.000	211	.	.	.	.	DCUN1D5	96	0	186	41	0.180616740088106	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227341	25227341	+	T	T	A	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A183T	p.Q61H	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A183T:p.Q61H	12p12.1	C3L-01637	.	.	.	.	.	.	.	.	rs17851045	16.20	D	D	B	B	D	D	M	D	D	0.760	D	D	D	0.647	0.659	0.905	1.857	D	D	D	D	D	T	3.041	23.500	0.997	D	N	0.298	3.768	0.383	4.239	0.998	0.722	0.710	0.710	0.735	.	5.770	5.770	2.812	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55499223;OCCURENCE=1(breast),2(liver),3(cervix),54(large_intestine),2(biliary_tract),1(ovary),1(NS),2(stomach),18(haematopoietic_and_lymphoid_tissue),1(urinary_tract),3(soft_tissue),21(pancreas),33(lung),1(thyroid)	KRAS	214	0	365	51	0.122596153846154	TRUE	TRUE
ENSG00000066117.15	.	BCM	GRCh38.p13	chr12	50090275	50090275	+	G	G	A	Missense_Mutation	SNP	ENST00000394963.9	exon8	c.G908A	p.R303Q	exonic	ENSG00000066117.15	.	nonsynonymous SNV	ENSG00000066117.15:ENST00000394963.9:exon8:c.G908A:p.R303Q	12q13.12	C3L-01637	.	.	.	.	.	.	.	.	.	9.20	T	D	P	B	D	D	L	T	D	0.746	T	T	T	0.242	0.495	0.307	1.646	D	T	T	T	D	D	3.581	25.000	0.999	D	D	0.392	4.297	0.516	5.312	1.000	0.719	0.723	0.702	0.711	.	5.320	5.320	9.940	1.176	0.676	1.000	0.998	0.949	217	SWIB_domain;SWIB/MDM2_domain	.	.	ID=COSV67411587;OCCURENCE=1(large_intestine)	SMARCD1	141	0	206	40	0.16260162601626	TRUE	TRUE
ENSG00000067221.14	.	BCM	GRCh38.p13	chr15	73989199	73989199	+	-	NA	G	Frame_Shift_Ins	INS	ENST00000541638.6	exon3	c.298dupC	p.Q100Pfs*13	exonic	ENSG00000067221.14	.	frameshift insertion	ENSG00000067221.14:ENST00000541638.6:exon3:c.298dupC:p.Q100Pfs*13	15q24.1	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STOML1	NA	NA	NA	NA	NA	NA	NA
ENSG00000103326.12	.	BCM	GRCh38.p13	chr16	547277	547290	+	TGGGCGTGTCCGCG	TGGGCGTGTCCGCG	-	Frame_Shift_Del	DEL	ENST00000219611.7	exon4	c.439_452del	p.W147Lfs*29	exonic	ENSG00000103326.12	.	frameshift deletion	ENSG00000103326.12:ENST00000219611.7:exon4:c.439_452del:p.W147Lfs*29	16p13.3	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CAPN15	100	0	263	59	0.183229813664596	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675160	7675160	+	G	G	C	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.C452G	p.P151R	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.C452G:p.P151R	17p13.1	C3L-01637	.	.	.	.	.	.	.	.	rs1057520000	19.20	D	D	D	D	D	D	M	D	D	0.856	D	D	D	0.912	0.851	0.972	1.705	T	D	D	D	D	D	3.760	25.700	0.998	D	D	0.690	6.985	0.565	5.812	1.000	0.722	0.698	0.698	0.735	.	5.590	4.630	8.190	1.176	0.676	1.000	0.202	0.669	434	p53,_DNA-binding_domain	.	.	ID=COSV52677206;OCCURENCE=2(breast),1(oesophagus),4(large_intestine),1(central_nervous_system),3(ovary),1(stomach),1(urinary_tract),1(kidney),1(pancreas),3(lung),2(endometrium)	TP53	276	0	393	92	0.189690721649485	TRUE	TRUE
ENSG00000094804.12	.	BCM	GRCh38.p13	chr17	40291285	40291285	+	C	C	G	Missense_Mutation	SNP	ENST00000209728.9	exon3	c.C406G	p.Q136E	exonic	ENSG00000094804.12	.	nonsynonymous SNV	ENSG00000094804.12:ENST00000209728.9:exon3:c.C406G:p.Q136E	17q21.2	C3L-01637	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.180	T	T	T	0.070	0.256	0.604	0.212	T	T	T	T	T	T	0.325	4.582	0.679	N	N	-0.428	1.323	-0.382	1.405	1.000	0.731	0.750	0.702	0.734	.	5.600	4.610	1.182	0.123	0.599	0.008	0.160	0.072	350	.	.	.	.	CDC6	236	0	413	66	0.137787056367432	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51076653	51076653	+	C	C	T	Nonsense_Mutation	SNP	ENST00000342988.8	exon11	c.C1324T	p.Q442X	exonic	ENSG00000141646.14	.	stopgain	ENSG00000141646.14:ENST00000342988.8:exon11:c.C1324T:p.Q442X	18q21.2	C3L-01637	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.986	.	.	.	.	.	.	.	.	.	D	D	.	.	8.276	42	0.998	D	N	1.240	28.024	1.115	28.821	1.000	0.732	0.744	0.725	0.714	.	6.030	6.030	7.773	1.026	0.599	1.000	0.997	0.997	865	SMAD_domain,_Dwarfin-type	.	.	ID=COSV61684132;OCCURENCE=1(large_intestine),1(biliary_tract),1(kidney),3(pancreas)	SMAD4	223	0	331	67	0.168341708542714	TRUE	TRUE
ENSG00000160321.15	.	BCM	GRCh38.p13	chr19	21974397	21974397	+	A	A	T	Missense_Mutation	SNP	ENST00000397126.9	exon4	c.T637A	p.S213T	exonic	ENSG00000160321.15	.	nonsynonymous SNV	ENSG00000160321.15:ENST00000397126.9:exon4:c.T637A:p.S213T	19p12	C3L-01637	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	.	N	H	T	N	0.124	T	T	T	0.007	0.352	0.105	0.009	T	T	T	T	T	T	0.721	8.643	0.119	N	N	-1.297	0.166	-1.480	0.116	0.000	0.487	0.574	0.574	0.564	.	1.360	-2.730	-1.296	0.458	0.410	0.000	0.001	0.001	988	Zinc_finger_C2H2-type	.	.	.	ZNF208	171	0	364	52	0.125	NA	TRUE
ENSG00000196437.12	.	BCM	GRCh38.p13	chr19	37414071	37414071	+	T	T	C	Missense_Mutation	SNP	ENST00000316950.11	exon6	c.A587G	p.N196S	exonic	ENSG00000196437.12	.	nonsynonymous SNV	ENSG00000196437.12:ENST00000316950.11:exon6:c.A587G:p.N196S	19q13.12	C3L-01637	9.091e-05	9.846e-05	0.0007	0	0	1.501e-05	0.0011	0	rs532445392	0.20	T	T	B	B	N	N	N	T	N	0.053	T	T	T	0.051	0.378	0.161	0.097	T	T	T	T	T	T	-0.523	0.106	0.796	N	N	-1.404	0.115	-1.392	0.156	0.216	0.615	0.634	0.659	0.794	.	3.730	-4.300	-0.973	-0.487	-0.220	0.000	0.941	0.992	633	Zinc_finger_C2H2-type	.	.	.	ZNF569	191	0	313	36	0.103151862464183	TRUE	NA
ENSG00000101445.10	.	BCM	GRCh38.p13	chr20	38918389	38918389	+	G	G	A	Missense_Mutation	SNP	ENST00000299824.6	exon11	c.G1427A	p.S476N	exonic	ENSG00000101445.10	.	nonsynonymous SNV	ENSG00000101445.10:ENST00000299824.6:exon11:c.G1427A:p.S476N	20q11.23	C3L-01637	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	N	L	T	N	0.053	T	T	T	0.124	0.273	0.596	0.415	T	T	T	T	D	T	2.917	23.200	0.996	D	D	0.062	2.738	0.226	3.315	1.000	0.672	0.698	0.659	0.711	.	5.200	5.200	4.097	1.176	0.676	1.000	0.999	0.982	889	.	.	.	ID=COSV100239676;OCCURENCE=1(stomach)	PPP1R16B	324	0	862	98	0.102083333333333	TRUE	TRUE
ENSG00000142149.9	.	BCM	GRCh38.p13	chr21	31990171	31990171	+	G	G	A	Missense_Mutation	SNP	ENST00000270112.7	exon9	c.G1300A	p.V434M	exonic	ENSG00000142149.9	.	nonsynonymous SNV	ENSG00000142149.9:ENST00000270112.7:exon9:c.G1300A:p.V434M	21q22.11	C3L-01637	7.415e-05	0	8.642e-05	0.0001	0	8.993e-05	0	6.057e-05	rs367545209	3.20	D	T	D	B	N	N	N	T	N	0.408	T	T	T	0.160	.	0.356	0.154	T	T	T	T	T	T	2.845	23.100	0.995	D	N	-0.035	2.389	0.010	2.393	0.107	0.615	0.574	0.659	0.564	.	4.000	2.130	2.591	1.176	0.676	1.000	1.000	0.989	800	.	.	.	ID=COSV54224899;OCCURENCE=1(adrenal_gland),1(central_nervous_system)	HUNK	230	0	292	45	0.13353115727003	TRUE	TRUE
ENSG00000075240.17	.	BCM	GRCh38.p13	chr22	46677148	46677148	+	C	C	G	Missense_Mutation	SNP	ENST00000406902.6	exon19	c.C1634G	p.P545R	exonic	ENSG00000075240.17	.	nonsynonymous SNV	ENSG00000075240.17:ENST00000406902.6:exon19:c.C1634G:p.P545R	22q13.31	C3L-01637	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	L	T	D	0.854	D	D	D	0.645	0.455	0.645	2.540	D	T	D	D	D	D	4.410	31	0.998	D	D	0.471	4.820	0.449	4.723	1.000	0.719	0.723	0.723	0.700	.	4.700	4.700	6.837	1.026	0.599	1.000	0.849	0.736	654	GRAM_domain;GRAMDC4,_PH-GRAM_domain	.	.	.	GRAMD4	175	0	272	63	0.188059701492537	TRUE	TRUE
ENSG00000170745.12	.	BCM	GRCh38.p13	chr2	17931566	17931566	+	T	T	C	Silent	SNP	ENST00000304101.9	exon3	c.T558C	p.L186L	exonic	ENSG00000170745.12	.	synonymous SNV	ENSG00000170745.12:ENST00000304101.9:exon3:c.T558C:p.L186L	2p24.2	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCNS3	162	0	376	68	0.153153153153153	TRUE	TRUE
ENSG00000118997.14	.	BCM	GRCh38.p13	chr2	195864977	195864977	+	T	T	C	Silent	SNP	ENST00000312428.11	exon41	c.A6678G	p.R2226R	exonic	ENSG00000118997.14	.	synonymous SNV	ENSG00000118997.14:ENST00000312428.11:exon41:c.A6678G:p.R2226R	2q32.3	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH7	99	0	192	44	0.186440677966102	TRUE	TRUE
ENSG00000153002.12	.	BCM	GRCh38.p13	chr3	148845476	148845476	+	A	A	C	Silent	SNP	ENST00000282957.9	exon9	c.A831C	p.A277A	exonic	ENSG00000153002.12	.	synonymous SNV	ENSG00000153002.12:ENST00000282957.9:exon9:c.A831C:p.A277A	3q24	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPB1	289	0	569	98	0.146926536731634	TRUE	TRUE
ENSG00000145246.14	.	BCM	GRCh38.p13	chr4	47563648	47563648	+	G	G	A	Silent	SNP	ENST00000273859.8	exon15	c.G2736A	p.A912A	exonic	ENSG00000145246.14	.	synonymous SNV	ENSG00000145246.14:ENST00000273859.8:exon15:c.G2736A:p.A912A	4p12	C3L-01637	4.122e-05	0	8.642e-05	0.0001	0	4.5e-05	0	0	rs201043225	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56707418;OCCURENCE=1(stomach)	ATP10D	138	0	231	28	0.108108108108108	TRUE	TRUE
ENSG00000205038.12	.	BCM	GRCh38.p13	chr8	109522325	109522325	+	T	T	A	Silent	SNP	ENST00000378402.10	exon74	c.T12171A	p.S4057S	exonic	ENSG00000205038.12	.	synonymous SNV	ENSG00000205038.12:ENST00000378402.10:exon74:c.T12171A:p.S4057S	8q23.2	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PKHD1L1	101	0	155	28	0.153005464480874	TRUE	TRUE
ENSG00000186583.12	.	BCM	GRCh38.p13	chr8	144040713	144040713	+	G	G	A	Silent	SNP	ENST00000377470.8	exon3	c.G912A	p.S304S	exonic	ENSG00000186583.12	.	synonymous SNV	ENSG00000186583.12:ENST00000377470.8:exon3:c.G912A:p.S304S	8q24.3	C3L-01637	1.667e-05	9.752e-05	0	0	0	0	0	6.083e-05	rs782610725	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66299223;OCCURENCE=2(skin)	SPATC1	201	0	330	58	0.149484536082474	TRUE	NA
ENSG00000170631.15	.	BCM	GRCh38.p13	chr8	144931344	144931344	+	G	G	T	Silent	SNP	ENST00000394909.7	exon3	c.C1443A	p.I481I	exonic	ENSG00000170631.15	.	synonymous SNV	ENSG00000170631.15:ENST00000394909.7:exon3:c.C1443A:p.I481I	8q24.3	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF16	184	0	438	62	0.124	TRUE	TRUE
ENSG00000197702.14	.	BCM	GRCh38.p13	chr11	12477933	12477933	+	C	C	T	Silent	SNP	ENST00000334956.15	exon4	c.C384T	p.V128V	exonic	ENSG00000197702.14	.	synonymous SNV	ENSG00000197702.14:ENST00000334956.15:exon4:c.C384T:p.V128V	11p15.3	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PARVA	367	0	817	45	0.0522041763341067	TRUE	TRUE
ENSG00000196557.13	.	BCM	GRCh38.p13	chr16	1201962	1201962	+	G	G	A	Silent	SNP	ENST00000348261.11	exon9	c.G1512A	p.Q504Q	exonic	ENSG00000196557.13	.	synonymous SNV	ENSG00000196557.13:ENST00000348261.11:exon9:c.G1512A:p.Q504Q	16p13.3	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA1H	146	0	353	74	0.173302107728337	TRUE	TRUE
ENSG00000099783.12	.	BCM	GRCh38.p13	chr19	8463593	8463593	+	T	T	G	Silent	SNP	ENST00000325495.9	exon5	c.T345G	p.A115A	exonic	ENSG00000099783.12	.	synonymous SNV	ENSG00000099783.12:ENST00000325495.9:exon5:c.T345G:p.A115A	19p13.2	C3L-01637	.	.	.	.	.	.	.	.	.	1.9	.	T	.	.	.	D	.	T	.	.	.	.	.	.	.	0.876	.	.	T	T	T	.	T	0.602	7.534	0.655	N	N	.	.	.	.	1.000	0.672	0.698	0.702	0.711	.	6.170	-5.540	-0.344	-0.580	-0.718	0.440	0.685	0.645	734	RNA_recognition_motif_domain	.	.	.	HNRNPM	165	0	366	22	0.0567010309278351	TRUE	TRUE
ENSG00000105409.19	.	BCM	GRCh38.p13	chr19	41985319	41985319	+	G	G	A	Silent	SNP	ENST00000644613.1	exon7	c.C711T	p.T237T	exonic	ENSG00000105409.19;ENSG00000285505.1	.	synonymous SNV	ENSG00000285505.1:ENST00000644613.1:exon7:c.C711T:p.T237T,ENSG00000105409.19:ENST00000648268.1:exon7:c.C711T:p.T237T	19q13.2	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP1A3	474	0	879	130	0.128840436075322	TRUE	TRUE
ENSG00000187244.12	.	BCM	GRCh38.p13	chr19	44813285	44813285	+	C	C	G	Silent	SNP	ENST00000270233.12	exon5	c.C540G	p.A180A	exonic	ENSG00000187244.12	.	synonymous SNV	ENSG00000187244.12:ENST00000270233.12:exon5:c.C540G:p.A180A	19q13.32	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BCAM	258	0	491	64	0.115315315315315	TRUE	TRUE
ENSG00000241973.11	.	BCM	GRCh38.p13	chr22	20798585	20798585	+	T	T	G	Silent	SNP	ENST00000255882.11	exon17	c.A2107C	p.R703R	exonic	ENSG00000241973.11	.	synonymous SNV	ENSG00000241973.11:ENST00000255882.11:exon17:c.A2107C:p.R703R	22q11.21	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PI4KA	220	0	390	86	0.180672268907563	TRUE	TRUE
ENSG00000134882.16	.	BCM	GRCh38.p13	chr13	99201442	99201442	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000134882.16	.	.	.	13q32.3	C3L-01637	.	.	.	.	.	.	.	.	.	1.15	D	T	B	B	.	N	.	.	N	0.048	T	T	T	0.013	0.251	0.150	.	.	.	T	T	T	T	0.704	8.494	0.954	N	N	-0.936	0.476	-1.009	0.478	1.000	0.267	0.219	0.520	0.250	.	3.540	1.120	0.172	1.043	0.607	0.013	0.124	0.039	888	.	.	.	.	UBAC2	149	0	224	57	0.202846975088968	TRUE	NA
ENSG00000121068.14	.	BCM	GRCh38.p13	chr17	61404987	61404987	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000121068.14	.	.	.	17q23.2	C3L-01637	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBX2	229	2	389	70	0.152505446623094	TRUE	NA
ENSG00000117713.20	.	BCM	GRCh38.p13	chr1	26771212	26771212	+	C	C	T	Nonsense_Mutation	SNP	ENST00000324856.13	exon12	c.C3292T	p.Q1098X	exonic	ENSG00000117713.20	.	stopgain	ENSG00000117713.20:ENST00000324856.13:exon12:c.C3292T:p.Q1098X	1p36.11	C3N-04119	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.985	.	.	.	.	.	.	.	.	.	D	D	.	.	7.274	37	0.998	D	N	1.061	15.972	0.940	15.590	1.000	0.722	0.699	0.698	0.592	.	5.430	5.430	7.844	0.947	0.599	1.000	1.000	1.000	412	ARID_DNA-binding_domain	.	.	ID=COSV61372190;OCCURENCE=1(stomach),1(pancreas),1(endometrium)	ARID1A	479	0	617	59	0.0872781065088757	TRUE	TRUE
ENSG00000090621.14	.	BCM	GRCh38.p13	chr1	39562159	39562159	+	C	C	T	Missense_Mutation	SNP	ENST00000372857.7	exon14	c.G1759A	p.A587T	exonic	ENSG00000090621.14	.	nonsynonymous SNV	ENSG00000090621.14:ENST00000372857.7:exon14:c.G1759A:p.A587T	1p34.3	C3N-04119	.	.	.	.	.	.	.	.	.	13.20	T	D	P	P	D	D	M	T	N	0.881	T	D	D	0.399	0.862	0.711	1.278	D	T	D	D	D	D	3.265	24.000	0.999	D	D	0.528	5.257	0.554	5.691	1.000	0.672	0.698	0.702	0.711	.	5.420	5.420	7.860	1.026	0.599	1.000	0.271	0.826	318	Polyadenylate-binding_protein/Hyperplastic_disc_protein	.	.	.	PABPC4	246	0	335	34	0.0921409214092141	TRUE	TRUE
ENSG00000116209.12	.	BCM	GRCh38.p13	chr1	54047276	54047276	+	A	A	T	Missense_Mutation	SNP	ENST00000234831.10	exon2	c.T286A	p.C96S	exonic	ENSG00000116209.12	.	nonsynonymous SNV	ENSG00000116209.12:ENST00000234831.10:exon2:c.T286A:p.C96S	1p32.3	C3N-04119	1.653e-05	0	0	0	0	3.012e-05	0	0	rs755400755	19.20	D	D	D	D	D	D	M	T	D	0.976	D	D	D	0.894	0.714	0.900	0.749	D	D	D	D	D	D	4.203	28.700	0.994	D	D	0.882	10.606	0.843	11.513	1.000	0.706	0.686	0.710	0.617	.	5.460	5.460	8.488	1.312	0.691	1.000	1.000	0.999	826	.	.	.	.	TMEM59	137	0	169	28	0.142131979695431	TRUE	NA
ENSG00000154342.6	.	BCM	GRCh38.p13	chr1	228059059	228059059	+	G	G	A	Nonsense_Mutation	SNP	ENST00000284523.2	exon4	c.G653A	p.W218X	exonic	ENSG00000154342.6	.	stopgain	ENSG00000154342.6:ENST00000284523.2:exon4:c.G653A:p.W218X	1q42.13	C3N-04119	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.835	.	.	.	.	.	.	.	.	.	D	D	.	.	8.373	42	0.995	D	N	0.930	11.848	0.793	9.929	1.000	0.598	0.563	0.607	0.639	.	4.580	4.580	9.866	1.176	0.618	1.000	1.000	0.994	721	.	.	.	.	WNT3A	247	0	378	41	0.0978520286396181	TRUE	TRUE
ENSG00000183780.13	.	BCM	GRCh38.p13	chr1	234316620	234316620	+	G	G	A	Missense_Mutation	SNP	ENST00000366617.3	exon4	c.G640A	p.A214T	exonic	ENSG00000183780.13	.	nonsynonymous SNV	ENSG00000183780.13:ENST00000366617.3:exon4:c.G640A:p.A214T	1q42.2	C3N-04119	8.259e-06	0	0	0	0	0	0	6.123e-05	rs762720695	14.20	D	D	D	D	D	D	L	T	N	0.859	T	T	D	0.428	0.601	0.134	1.545	D	T	D	D	D	D	4.372	31	0.999	D	D	0.766	8.156	0.788	9.773	1.000	0.615	0.588	0.659	0.542	.	5.730	5.730	8.012	1.176	0.676	1.000	0.999	0.992	969	EamA_domain	.	.	ID=COSV100784683;OCCURENCE=1(central_nervous_system),1(endometrium)	SLC35F3	89	0	133	25	0.158227848101266	TRUE	NA
ENSG00000198601.3	.	BCM	GRCh38.p13	chr1	248180349	248180349	+	C	C	T	Missense_Mutation	SNP	ENST00000641211.1	exon3	c.C364T	p.R122C	exonic	ENSG00000198601.3	.	nonsynonymous SNV	ENSG00000198601.3:ENST00000641211.1:exon3:c.C364T:p.R122C	1q44	C3N-04119	0.0003	0	0	0	0	0	0	0.0022	rs563979686	3.20	T	D	B	B	N	N	M	T	D	0.081	T	T	T	0.241	0.558	0.425	0.152	T	T	T	T	T	T	1.056	12.300	0.510	N	N	-1.132	0.279	-1.288	0.217	0.000	0.487	0.574	0.574	0.564	.	1.880	-2.560	-0.119	0.372	-0.649	0.196	0.001	0.001	976	GPCR,_rhodopsin-like,_7TM	.	.	.	OR2M2	320	0	300	38	0.112426035502959	TRUE	NA
ENSG00000158089.15	.	BCM	GRCh38.p13	chr2	30992881	30992881	+	G	G	A	Missense_Mutation	SNP	ENST00000349752.10	exon2	c.C256T	p.R86W	exonic	ENSG00000158089.15	.	nonsynonymous SNV	ENSG00000158089.15:ENST00000349752.10:exon2:c.C256T:p.R86W	2p23.1	C3N-04119	0.0004	0	8.64e-05	0	0	0.0008	0	0	rs143970227	11.18	D	D	D	P	.	D	M	T	D	0.903	T	T	D	0.471	.	0.911	.	.	T	T	D	T	D	2.185	20.800	0.999	D	D	0.681	6.863	0.635	6.692	0.999	0.752	0.588	0.390	0.564	.	4.960	4.960	4.158	1.176	0.676	1.000	0.998	0.882	934	.	.	.	ID=COSV61112843;OCCURENCE=1(central_nervous_system)	GALNT14	177	1	304	31	0.0925373134328358	TRUE	NA
ENSG00000152154.11	.	BCM	GRCh38.p13	chr2	39666352	39666352	+	C	C	A	Missense_Mutation	SNP	ENST00000281961.3	exon1	c.C378A	p.D126E	exonic	ENSG00000152154.11	.	nonsynonymous SNV	ENSG00000152154.11:ENST00000281961.3:exon1:c.C378A:p.D126E	2p22.1	C3N-04119	.	.	.	.	.	.	.	.	.	6.20	T	T	P	B	D	D	L	T	N	0.106	T	T	D	0.146	0.428	0.043	0.828	D	T	T	T	D	T	2.288	21.500	0.959	D	N	0.015	2.564	0.063	2.586	1.000	0.726	0.610	0.594	0.568	.	3.550	3.550	0.109	0.059	0.485	0.725	1.000	0.998	641	.	.	.	.	TMEM178A	181	0	264	32	0.108108108108108	TRUE	TRUE
ENSG00000155052.14	.	BCM	GRCh38.p13	chr2	124789917	124789917	+	G	G	A	Missense_Mutation	SNP	ENST00000431078.1	exon18	c.G2765A	p.R922K	exonic	ENSG00000155052.14	.	nonsynonymous SNV	ENSG00000155052.14:ENST00000431078.1:exon18:c.G2765A:p.R922K	2q14.3	C3N-04119	.	.	.	.	.	.	.	.	.	5.20	T	T	P	B	N	D	M	T	N	0.277	T	T	T	0.200	0.511	0.463	0.352	T	T	T	T	D	T	3.046	23.500	0.992	D	D	0.220	3.393	0.228	3.324	0.000	0.595	0.574	0.598	0.564	.	5.240	3.310	4.167	1.176	0.676	1.000	0.995	0.865	942	Laminin_G_domain	.	.	.	CNTNAP5	121	0	174	11	0.0594594594594595	TRUE	TRUE
ENSG00000067066.17	.	BCM	GRCh38.p13	chr2	230462473	230462473	+	G	G	A	Missense_Mutation	SNP	ENST00000264052.9	exon10	c.G1012A	p.D338N	exonic	ENSG00000067066.17	.	nonsynonymous SNV	ENSG00000067066.17:ENST00000264052.9:exon10:c.G1012A:p.D338N	2q37.1	C3N-04119	.	.	.	.	.	.	.	.	.	6.20	D	D	D	P	N	N	L	D	N	0.214	T	T	D	0.053	0.205	0.808	0.592	T	T	T	T	T	D	2.315	21.700	0.997	N	N	-0.382	1.423	-0.556	1.113	0.995	0.707	0.702	0.574	0.714	.	4.090	2.190	0.512	1.176	0.676	0.000	0.004	0.002	946	.	.	.	.	SP100	255	0	272	23	0.0779661016949153	TRUE	TRUE
ENSG00000132330.18	.	BCM	GRCh38.p13	chr2	238081821	238081821	+	G	G	C	Missense_Mutation	SNP	ENST00000254663.12	exon5	c.G597C	p.E199D	exonic	ENSG00000132330.18	.	nonsynonymous SNV	ENSG00000132330.18:ENST00000254663.12:exon5:c.G597C:p.E199D	2q37.3	C3N-04119	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	H	D	D	0.901	D	D	D	0.636	0.919	0.895	0.392	T	.	D	D	D	D	3.857	26.100	0.998	D	D	0.583	5.758	0.538	5.523	1.000	0.707	0.725	0.725	0.714	.	5.840	4.950	5.869	1.176	0.676	1.000	0.686	0.233	964	Aminotransferase_class_V_domain	.	.	.	SCLY	179	0	249	28	0.101083032490975	TRUE	TRUE
ENSG00000168016.14	.	BCM	GRCh38.p13	chr3	36832015	36832015	+	C	C	T	Missense_Mutation	SNP	ENST00000429976.5	exon21	c.G7436A	p.R2479Q	exonic	ENSG00000168016.14	.	nonsynonymous SNV	ENSG00000168016.14:ENST00000429976.5:exon21:c.G7436A:p.R2479Q	3p22.2	C3N-04119	8.28e-06	0	0	0	0	1.498e-05	0	0	rs756325744	5.20	D	D	D	P	N	N	M	T	N	0.264	T	T	T	0.055	.	0.364	0.212	T	T	T	T	D	T	2.869	23.200	0.999	N	N	0.222	3.402	0.142	2.913	0.065	0.706	0.634	0.710	0.655	.	5.050	1.280	0.582	1.022	0.596	0.972	1.000	0.996	759	.	.	.	.	TRANK1	205	0	280	24	0.0789473684210526	TRUE	NA
ENSG00000068001.14	.	BCM	GRCh38.p13	chr3	50318416	50318416	+	G	G	A	Missense_Mutation	SNP	ENST00000357750.9	exon4	c.C1135T	p.R379C	exonic	ENSG00000068001.14	.	nonsynonymous SNV	ENSG00000068001.14:ENST00000357750.9:exon4:c.C1135T:p.R379C	3p21.31	C3N-04119	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.482	T	T	D	0.189	0.404	0.690	1.583	T	D	T	T	D	D	4.164	28.300	0.999	D	D	0.732	7.587	0.706	7.863	1.000	0.672	0.702	0.702	0.639	.	5.930	5.930	2.037	1.176	0.676	0.995	1.000	0.998	2	.	.	.	ID=COSV63306114;OCCURENCE=1(NS)	HYAL2	231	0	481	48	0.0907372400756144	TRUE	TRUE
ENSG00000163618.18	.	BCM	GRCh38.p13	chr3	62650935	62650935	+	C	C	T	Missense_Mutation	SNP	ENST00000383710.9	exon5	c.G1115A	p.R372H	exonic	ENSG00000163618.18	.	nonsynonymous SNV	ENSG00000163618.18:ENST00000383710.9:exon5:c.G1115A:p.R372H	3p14.2	C3N-04119	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.856	T	T	T	0.349	0.570	0.779	1.141	T	D	D	T	D	D	4.089	27.700	0.999	D	D	0.848	9.802	0.864	12.297	1.000	0.638	0.574	0.653	0.530	.	6.030	6.030	7.905	1.026	0.599	1.000	1.000	0.998	927	.	.	.	ID=COSV99337214;OCCURENCE=1(lung)	CADPS	437	0	508	48	0.0863309352517986	TRUE	NA
ENSG00000082684.16	.	BCM	GRCh38.p13	chr3	122961221	122961221	+	C	C	T	Missense_Mutation	SNP	ENST00000357599.8	exon2	c.G43A	p.V15I	exonic	ENSG00000082684.16	.	nonsynonymous SNV	ENSG00000082684.16:ENST00000357599.8:exon2:c.G43A:p.V15I	3q21.1	C3N-04119	.	.	.	.	.	.	.	.	rs555943228	1.18	D	.	B	B	.	N	N	T	N	0.082	T	T	T	0.026	0.207	0.310	0.258	T	T	T	T	T	T	-0.573	0.083	0.897	N	N	-1.198	0.228	-1.266	0.232	1.000	0.706	0.590	0.710	0.530	.	3.230	-1.910	-1.582	-0.375	0.549	0.000	0.000	0.001	583	.	.	.	ID=COSV52093968;OCCURENCE=1(large_intestine),1(NS)	SEMA5B	177	0	216	22	0.092436974789916	TRUE	TRUE
ENSG00000169026.12	.	BCM	GRCh38.p13	chr4	682841	682841	+	G	G	A	Nonsense_Mutation	SNP	ENST00000404286.6	exon9	c.C1204T	p.R402X	exonic	ENSG00000169026.12	.	stopgain	ENSG00000169026.12:ENST00000404286.6:exon9:c.C1204T:p.R402X	4p16.3	C3N-04119	0.0003	0	0	0	0	0	0	0.0019	rs772057703	3.6	.	.	.	.	N	A	.	.	.	0.097	.	.	.	.	.	.	.	.	.	D	D	.	.	6.296	35	0.997	N	N	0.161	3.135	-0.180	1.835	1.000	0.635	0.694	0.644	0.605	.	4.200	3.330	0.925	1.166	0.665	0.001	0.014	0.011	824	Major_facilitator_superfamily_domain	.	.	.	SLC49A3	190	0	284	43	0.131498470948012	TRUE	NA
ENSG00000173610.12	.	BCM	GRCh38.p13	chr4	69647487	69647487	+	A	A	C	Missense_Mutation	SNP	ENST00000514019.1	exon2	c.T158G	p.L53R	exonic	ENSG00000173610.12	.	nonsynonymous SNV	ENSG00000173610.12:ENST00000514019.1:exon2:c.T158G:p.L53R	4q13.3	C3N-04119	.	.	.	.	.	.	.	.	.	15.17	D	D	D	D	D	.	.	T	D	0.944	D	D	D	0.627	0.786	0.735	0.066	T	.	D	D	D	D	3.082	23.600	0.996	D	D	0.598	5.900	0.437	4.630	0.011	0.554	0.574	0.618	0.621	.	5.930	5.930	7.336	1.288	0.756	0.726	0.818	0.371	946	.	.	.	.	UGT2A1	160	0	133	14	0.0952380952380952	TRUE	TRUE
ENSG00000039139.9	.	BCM	GRCh38.p13	chr5	13839422	13839422	+	G	G	A	Missense_Mutation	SNP	ENST00000265104.4	exon35	c.C5816T	p.A1939V	exonic	ENSG00000039139.9	.	nonsynonymous SNV	ENSG00000039139.9:ENST00000265104.4:exon35:c.C5816T:p.A1939V	5p15.2	C3N-04119	2.472e-05	0	0	0	0	4.497e-05	0	0	rs376871205	2.19	D	.	B	B	N	N	N	T	N	0.188	T	T	T	0.036	.	0.390	0.257	T	T	T	T	T	D	1.996	19.230	0.997	N	N	-0.470	1.236	-0.355	1.456	0.772	0.554	0.574	0.618	0.564	.	4.930	4.050	0.447	1.176	0.676	0.000	0.995	0.988	689	.	.	.	.	DNAH5	214	0	153	16	0.0946745562130177	TRUE	NA
ENSG00000164327.13	.	BCM	GRCh38.p13	chr5	38952265	38952265	+	T	T	C	Missense_Mutation	SNP	ENST00000357387.8	exon30	c.A3058G	p.S1020G	exonic	ENSG00000164327.13	.	nonsynonymous SNV	ENSG00000164327.13:ENST00000357387.8:exon30:c.A3058G:p.S1020G	5p13.1	C3N-04119	8.276e-06	0	0	0	0	0	0	6.068e-05	rs757720947	10.20	D	T	D	D	D	D	L	T	N	0.739	T	T	D	0.215	0.199	0.162	1.136	T	T	T	T	D	D	4.109	27.800	0.999	D	D	0.690	6.984	0.681	7.410	1.000	0.707	0.725	0.651	0.714	.	5.520	5.520	7.645	1.138	0.609	1.000	1.000	0.995	226	.	.	.	.	RICTOR	268	0	199	20	0.091324200913242	TRUE	NA
ENSG00000113319.13	.	BCM	GRCh38.p13	chr5	81094918	81094918	+	G	G	A	Missense_Mutation	SNP	ENST00000265080.9	exon12	c.G1681A	p.A561T	exonic	ENSG00000113319.13	.	nonsynonymous SNV	ENSG00000113319.13:ENST00000265080.9:exon12:c.G1681A:p.A561T	5q14.1	C3N-04119	1.649e-05	0	0	0	0	1.499e-05	0	6.058e-05	rs553413159	1.20	D	T	B	B	N	N	N	T	N	0.087	T	T	T	0.133	0.329	0.346	0.409	T	T	T	T	T	T	1.164	13.340	0.984	N	N	-0.513	1.151	-0.490	1.218	0.007	0.615	0.574	0.659	0.530	.	5.930	2.840	0.183	-0.304	-0.104	0.000	0.029	0.230	917	Pleckstrin_homology_domain	.	.	ID=COSV54128496;OCCURENCE=1(large_intestine)	RASGRF2	298	2	389	33	0.0781990521327014	TRUE	TRUE
ENSG00000113319.13	.	BCM	GRCh38.p13	chr5	81113905	81113905	+	C	C	T	Nonsense_Mutation	SNP	ENST00000265080.9	exon15	c.C2455T	p.R819X	exonic	ENSG00000113319.13	.	stopgain	ENSG00000113319.13:ENST00000265080.9:exon15:c.C2455T:p.R819X	5q14.1	C3N-04119	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	N	A	.	.	.	0.922	.	.	.	.	.	.	.	.	.	D	D	.	.	8.035	40	0.996	D	D	0.525	5.233	0.298	3.708	0.010	0.615	0.590	0.659	0.586	.	4.940	3.000	1.464	1.026	0.599	1.000	0.650	0.104	889	Ras-like_guanine_nucleotide_exchange_factor,_N-terminal	.	.	ID=COSV54122570;OCCURENCE=3(oesophagus),1(central_nervous_system),1(biliary_tract)	RASGRF2	124	0	180	30	0.142857142857143	TRUE	TRUE
ENSG00000120729.10	.	BCM	GRCh38.p13	chr5	137887257	137887257	+	C	C	T	Nonsense_Mutation	SNP	ENST00000239926.9	exon10	c.C1369T	p.R457X	exonic	ENSG00000120729.10	.	stopgain	ENSG00000120729.10:ENST00000239926.9:exon10:c.C1369T:p.R457X	5q31.2	C3N-04119	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.945	.	.	.	.	.	.	.	.	.	D	D	.	.	7.355	37	0.996	D	N	0.652	6.498	0.512	5.269	1.000	0.487	0.542	0.574	0.564	.	5.810	3.990	3.072	1.026	0.549	1.000	1.000	0.998	138	.	.	.	ID=COSV99295896;OCCURENCE=2(urinary_tract)	MYOT	354	0	329	34	0.09366391184573	TRUE	TRUE
ENSG00000253953.2	.	BCM	GRCh38.p13	chr5	141390040	141390040	+	C	C	G	Missense_Mutation	SNP	ENST00000519479.1	exon1	c.C2156G	p.P719R	exonic	ENSG00000253953.2	.	nonsynonymous SNV	ENSG00000253953.2:ENST00000519479.1:exon1:c.C2156G:p.P719R	5q31.3	C3N-04119	.	.	.	.	.	.	.	.	.	4.18	D	D	B	B	.	N	M	T	D	0.161	T	T	T	0.016	0.395	0.183	.	.	T	T	T	T	T	1.253	14.050	0.901	N	N	-0.814	0.634	-0.844	0.697	0.872	0.549	0.588	0.693	0.616	.	5.850	1.680	0.315	0.047	0.449	0.000	0.002	0.045	764	Cadherin,_cytoplasmic_C-terminal_domain	.	.	.	PCDHGB4	344	0	497	60	0.107719928186715	TRUE	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152416423	152416423	+	C	C	T	Missense_Mutation	SNP	ENST00000367255.10	exon41	c.G6014A	p.R2005Q	exonic	ENSG00000131018.24	.	nonsynonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon41:c.G6014A:p.R2005Q	6q25.2	C3N-04119	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.151	T	T	T	0.032	0.287	0.203	0.154	T	T	T	T	T	T	0.602	7.532	0.632	N	N	-0.820	0.626	-0.819	0.731	0.000	0.487	0.574	0.574	0.564	.	5.970	3.010	0.933	-0.236	-0.175	0.040	0.000	0.004	869	.	.	.	.	SYNE1	393	0	383	43	0.10093896713615	TRUE	TRUE
ENSG00000105983.22	.	BCM	GRCh38.p13	chr7	156688177	156688177	+	C	C	G	Missense_Mutation	SNP	ENST00000353442.10	exon16	c.G1240C	p.D414H	exonic	ENSG00000105983.22	.	nonsynonymous SNV	ENSG00000105983.22:ENST00000353442.10:exon16:c.G1240C:p.D414H	7q36.3	C3N-04119	.	.	.	.	.	.	.	.	.	14.20	D	D	P	P	D	D	M	T	D	0.991	T	T	D	0.660	0.958	0.805	0.835	D	T	D	D	D	D	3.820	25.900	0.996	D	D	0.794	8.666	0.784	9.676	1.000	0.732	0.744	0.710	0.728	.	5.510	5.510	7.624	1.022	0.596	1.000	1.000	0.997	945	.	.	.	.	LMBR1	63	0	92	7	0.0707070707070707	TRUE	TRUE
ENSG00000275591.5	.	BCM	GRCh38.p13	chr8	6823723	6823723	+	G	G	T	Missense_Mutation	SNP	ENST00000618742.3	exon4	c.C435A	p.S145R	exonic	ENSG00000275591.5	.	nonsynonymous SNV	ENSG00000275591.5:ENST00000618742.3:exon4:c.C435A:p.S145R	8p23.1	C3N-04119	.	.	.	.	.	.	.	.	.	5.9	.	D	D	D	.	.	.	.	.	0.756	.	.	.	.	.	0.465	.	T	T	D	D	.	T	0.464	6.124	0.607	N	.	.	.	.	.	0.999	0.162	0.060	0.175	0.059	0.085	4.640	-4.540	-0.355	-0.984	-0.946	0.066	0.000	0.031	994	.	.	.	.	XKR5	290	3	390	21	0.0510948905109489	NA	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971168	21971168	+	A	A	G	Missense_Mutation	SNP	ENST00000304494.9	exon2	c.T191C	p.L64P	exonic	ENSG00000147889.17	.	nonsynonymous SNV	ENSG00000147889.17:ENST00000304494.9:exon2:c.T191C:p.L64P	9p21.3	C3N-04119	.	.	.	.	.	.	.	.	.	16.18	D	D	D	D	.	D	.	T	D	0.922	D	D	D	0.899	0.733	0.956	1.566	T	D	D	D	D	D	4.503	32	0.999	D	D	0.687	6.945	0.678	7.367	1.000	0.677	0.383	0.608	0.601	.	5.790	5.790	8.610	1.312	0.756	1.000	0.249	0.876	900	Ankyrin_repeat-containing_domain	.	.	ID=COSV58729783;OCCURENCE=2(breast),1(ovary)	CDKN2A	640	0	801	94	0.105027932960894	NA	TRUE
ENSG00000136826.15	.	BCM	GRCh38.p13	chr9	107485858	107485858	+	T	T	A	Missense_Mutation	SNP	ENST00000374672.5	exon5	c.A1333T	p.R445W	exonic	ENSG00000136826.15	.	nonsynonymous SNV	ENSG00000136826.15:ENST00000374672.5:exon5:c.A1333T:p.R445W	9q31.2	C3N-04119	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	N	D	.	T	D	0.815	T	T	D	0.397	.	0.803	2.555	D	D	D	D	D	T	4.419	31	0.999	D	D	0.337	3.974	0.302	3.729	1.000	0.653	0.590	0.659	0.669	.	5.820	2.210	5.310	1.138	0.665	1.000	1.000	0.998	744	Zinc_finger_C2H2-type	.	.	.	KLF4	252	1	341	37	0.0978835978835979	TRUE	TRUE
ENSG00000148843.15	.	BCM	GRCh38.p13	chr10	103425116	103425116	+	G	G	T	Missense_Mutation	SNP	ENST00000369797.8	exon20	c.G2896T	p.D966Y	exonic	ENSG00000148843.15	.	nonsynonymous SNV	ENSG00000148843.15:ENST00000369797.8:exon20:c.G2896T:p.D966Y	10q24.33	C3N-04119	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	L	T	D	0.648	T	T	T	0.502	0.800	0.512	0.864	T	T	D	T	D	D	4.266	29.300	0.995	D	D	0.742	7.753	0.785	9.687	1.000	0.719	0.702	0.723	0.714	.	5.650	5.650	9.082	1.176	0.618	1.000	1.000	0.995	217	.	.	.	.	PDCD11	351	0	585	57	0.088785046728972	TRUE	TRUE
ENSG00000171811.14	.	BCM	GRCh38.p13	chr10	132899547	132899547	+	G	G	A	Missense_Mutation	SNP	ENST00000368586.10	exon23	c.C3044T	p.T1015M	exonic	ENSG00000171811.14	.	nonsynonymous SNV	ENSG00000171811.14:ENST00000368586.10:exon23:c.C3044T:p.T1015M	10q26.3	C3N-04119	.	.	.	.	.	.	.	.	rs898358192	2.16	D	T	.	.	.	N	.	T	N	0.079	T	T	D	0.069	0.234	0.040	0.114	T	T	T	T	T	T	0.497	6.473	0.864	N	N	-1.127	0.283	-1.207	0.277	0.000	0.487	0.574	0.547	0.542	.	3.720	-0.431	0.406	0.233	-0.105	0.000	0.025	0.049	994	.	.	.	.	CFAP46	116	0	181	23	0.112745098039216	TRUE	NA
ENSG00000186119.8	.	BCM	GRCh38.p13	chr11	55819794	55819794	+	A	A	T	Missense_Mutation	SNP	ENST00000333976.6	exon1	c.A165T	p.K55N	exonic	ENSG00000186119.8	.	nonsynonymous SNV	ENSG00000186119.8:ENST00000333976.6:exon1:c.A165T:p.K55N	11q12.1	C3N-04119	.	.	.	.	.	.	.	.	.	4.20	D	D	B	B	D	N	N	T	D	0.083	T	T	T	0.034	0.400	0.245	0.101	T	T	T	T	T	T	0.727	8.702	0.983	N	N	-1.064	0.339	-1.088	0.388	0.000	0.487	0.574	0.574	0.564	.	4.940	-3.660	-4.848	-0.224	-0.101	0.000	0.056	0.767	156	GPCR,_rhodopsin-like,_7TM	.	.	.	OR5D18	129	0	145	10	0.0645161290322581	TRUE	TRUE
ENSG00000173039.19	.	BCM	GRCh38.p13	chr11	65659770	65659770	+	T	T	C	Missense_Mutation	SNP	ENST00000406246.8	exon6	c.A455G	p.Y152C	exonic	ENSG00000173039.19	.	nonsynonymous SNV	ENSG00000173039.19:ENST00000406246.8:exon6:c.A455G:p.Y152C	11q13.1	C3N-04119	.	.	.	.	.	.	.	.	.	10.20	D	T	D	D	D	D	L	T	N	0.679	T	T	D	0.193	0.594	0.440	2.699	T	T	T	T	D	D	3.458	24.600	0.984	D	D	0.177	3.202	0.201	3.189	1.000	0.672	0.702	0.702	0.711	.	4.710	4.710	2.812	1.138	0.665	0.997	0.996	0.935	281	Rel_homology_domain_(RHD),_DNA-binding_domain	.	.	.	RELA	109	0	192	25	0.115207373271889	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-04119	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	298	0	285	37	0.114906832298137	TRUE	TRUE
ENSG00000135476.12	.	BCM	GRCh38.p13	chr12	53286904	53286904	+	C	C	T	Missense_Mutation	SNP	ENST00000257934.9	exon18	c.C4168T	p.R1390C	exonic	ENSG00000135476.12	.	nonsynonymous SNV	ENSG00000135476.12:ENST00000257934.9:exon18:c.C4168T:p.R1390C	12q13.13	C3N-04119	.	.	.	.	.	.	.	.	rs149944800	14.20	D	D	D	D	D	D	M	T	D	0.718	T	T	D	0.196	.	0.482	0.996	T	D	T	T	D	D	4.182	28.500	0.999	D	D	0.576	5.692	0.496	5.124	1.000	0.672	0.702	0.644	0.636	.	5.080	5.080	4.496	1.022	0.596	0.992	0.876	0.963	706	.	.	.	.	ESPL1	41	0	81	10	0.10989010989011	TRUE	NA
ENSG00000140678.17	.	BCM	GRCh38.p13	chr16	31380296	31380296	+	C	C	T	Missense_Mutation	SNP	ENST00000268296.9	exon27	c.C3091T	p.R1031C	exonic	ENSG00000140678.17	.	nonsynonymous SNV	ENSG00000140678.17:ENST00000268296.9:exon27:c.C3091T:p.R1031C	16p11.2	C3N-04119	6.734e-05	0.0002	0.0002	0	0	0	0	0.0002	rs377108919	8.19	D	D	D	D	.	N	M	T	D	0.170	T	T	T	0.146	.	0.746	0.850	T	D	T	T	D	T	1.629	16.560	0.999	N	N	0.060	2.732	-0.102	2.042	0.000	0.706	0.710	0.547	0.568	.	4.700	1.410	-0.140	-0.280	0.549	0.000	0.535	0.912	394	.	.	.	ID=COSV51641830;OCCURENCE=1(large_intestine),1(stomach)	ITGAX	325	0	465	50	0.0970873786407767	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674957	7674957	+	G	G	A	Nonsense_Mutation	SNP	ENST00000269305.8	exon6	c.C574T	p.Q192X	exonic	ENSG00000141510.17	.	stopgain	ENSG00000141510.17:ENST00000269305.8:exon6:c.C574T:p.Q192X	17p13.1	C3N-04119	.	.	.	.	.	.	.	.	rs866380588	5.6	.	.	.	.	D	A	.	.	.	0.927	.	.	.	.	.	.	.	.	.	D	D	.	.	7.987	40	0.994	D	N	0.694	7.042	0.457	4.792	0.807	0.722	0.698	0.702	0.735	.	5.410	3.360	3.131	1.176	0.676	1.000	0.999	0.979	433	p53,_DNA-binding_domain	.	.	ID=COSV52660737;OCCURENCE=34(breast),7(liver),12(oesophagus),2(cervix),1(placenta),12(large_intestine),1(central_nervous_system),4(biliary_tract),16(ovary),1(NS),7(haematopoietic_and_lymphoid_tissue),5(stomach),2(kidney),15(urinary_tract),5(pancreas),8(skin),1(prostate),17(lung),4(thyroid),13(upper_aerodigestive_tract),1(eye),2(endometrium)	TP53	481	0	623	86	0.1212976022567	TRUE	TRUE
ENSG00000172716.16	.	BCM	GRCh38.p13	chr17	35363623	35363623	+	C	C	T	Missense_Mutation	SNP	ENST00000394566.5	exon4	c.G185A	p.R62Q	exonic	ENSG00000172716.16	.	nonsynonymous SNV	ENSG00000172716.16:ENST00000394566.5:exon4:c.G185A:p.R62Q	17q12	C3N-04119	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.040	T	T	T	0.028	0.415	0.040	0.086	T	T	T	T	T	T	0.345	4.808	0.921	N	N	-1.240	0.200	-1.275	0.226	0.999	0.707	0.634	0.547	0.714	.	3.850	-5.140	0.259	-1.148	-0.171	0.000	0.001	0.710	581	.	.	.	.	SLFN11	130	0	194	21	0.0976744186046512	TRUE	NA
ENSG00000177303.10	.	BCM	GRCh38.p13	chr17	75501841	75501841	+	C	C	T	Missense_Mutation	SNP	ENST00000321617.8	exon18	c.G3233A	p.R1078Q	exonic	ENSG00000177303.10	.	nonsynonymous SNV	ENSG00000177303.10:ENST00000321617.8:exon18:c.G3233A:p.R1078Q	17q25.1	C3N-04119	2.789e-05	0.0001	0	0	0	1.62e-05	0	0.0001	rs766946055	1.20	T	T	B	B	N	N	N	T	N	0.082	T	T	D	0.040	.	0.337	0.153	T	T	T	T	T	T	-0.410	0.183	0.588	N	N	-1.562	0.064	-1.553	0.089	1.000	0.635	0.551	0.644	0.636	.	4.900	-2.320	-1.601	-0.697	-0.916	0.000	0.000	0.000	976	.	.	.	.	CASKIN2	25	0	55	9	0.140625	TRUE	NA
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51058402	51058402	+	C	C	T	Nonsense_Mutation	SNP	ENST00000342988.8	exon7	c.C850T	p.Q284X	exonic	ENSG00000141646.14	.	stopgain	ENSG00000141646.14:ENST00000342988.8:exon7:c.C850T:p.Q284X	18q21.2	C3N-04119	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.982	.	.	.	.	.	.	.	.	.	D	D	.	.	6.756	36	0.998	D	N	0.984	13.420	0.888	13.256	1.000	0.707	0.725	0.725	0.714	.	6.170	6.170	4.416	1.026	0.599	1.000	1.000	1.000	669	.	.	.	ID=COSV61693823;OCCURENCE=1(pancreas)	SMAD4	504	0	509	71	0.122413793103448	TRUE	TRUE
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8126314	8126314	+	G	G	A	Missense_Mutation	SNP	ENST00000600128.6	exon21	c.C2588T	p.T863M	exonic	ENSG00000142449.13	.	nonsynonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon21:c.C2588T:p.T863M	19p13.2	C3N-04119	0.0002	0.0007	0	0.0013	0	8.412e-05	0	0	rs139953945	2.20	D	T	B	B	U	N	L	D	N	0.111	T	T	T	0.180	.	0.498	0.201	T	T	T	T	T	T	0.421	5.663	0.837	N	N	-1.417	0.110	-1.537	0.095	0.045	0.707	0.574	0.725	0.613	.	2.930	-2.880	0.362	-1.022	-0.834	0.001	0.007	0.001	934	.	.	.	.	FBN3	242	0	411	32	0.072234762979684	TRUE	NA
ENSG00000182584.6	.	BCM	GRCh38.p13	chr20	33667936	33667936	+	G	G	A	Missense_Mutation	SNP	ENST00000330271.6	exon1	c.G439A	p.A147T	exonic	ENSG00000182584.6	.	nonsynonymous SNV	ENSG00000182584.6:ENST00000330271.6:exon1:c.G439A:p.A147T	20q11.22	C3N-04119	.	.	.	.	.	.	.	.	.	9.20	T	T	P	P	D	D	L	D	N	0.422	D	D	D	0.461	0.530	0.630	0.870	T	T	D	D	D	T	3.134	23.700	0.998	N	N	-0.060	2.306	-0.146	1.921	1.000	0.437	0.219	0.607	0.250	.	4.970	3.950	3.233	1.101	0.590	0.920	0.047	0.017	117	.	.	.	.	ACTL10	198	0	345	31	0.0824468085106383	TRUE	TRUE
ENSG00000182798.10	.	BCM	GRCh38.p13	chrX	16170836	16170836	+	C	C	T	Missense_Mutation	SNP	ENST00000400004.6	exon2	c.C454T	p.R152W	exonic	ENSG00000182798.10	.	nonsynonymous SNV	ENSG00000182798.10:ENST00000400004.6:exon2:c.C454T:p.R152W	Xp22.2	C3N-04119	.	.	.	.	.	.	.	.	.	4.17	D	D	.	.	N	N	M	T	D	0.268	T	T	T	0.051	.	0.048	0.768	T	T	T	T	T	T	1.832	17.970	0.992	N	.	.	.	.	.	0.823	.	.	.	.	.	2.410	-4.360	-0.471	-0.783	-0.224	0.000	0.000	0.002	416	MAGE_homology_domain	.	.	.	MAGEB17	79	1	113	35	0.236486486486486	TRUE	NA
ENSG00000080371.6	.	BCM	GRCh38.p13	chr12	71770590	71770590	+	A	A	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000080371.6	ENST00000261263.5:exon3:c.220-2A>C	.	.	12q21.1	C3N-04119	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.871	35	0.988	D	.	1.026	14.760	0.848	11.697	0.999	0.295	0.304	0.175	0.221	0.891	5.210	4.070	8.771	1.312	0.750	1.000	0.984	0.908	813	.	.	.	.	RAB21	232	1	201	11	0.0518867924528302	TRUE	TRUE
ENSG00000103319.12	.	BCM	GRCh38.p13	chr16	22260461	22260461	+	G	G	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000103319.12	ENST00000263026.10:exon11:c.1232-1G>C	.	.	16p12.2	C3N-04119	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.442	34	0.995	D	.	1.164	20.946	1.020	20.090	0.984	0.295	0.304	0.126	0.118	0.983	5.650	5.650	6.173	1.176	0.676	1.000	0.988	0.890	553	.	.	.	ID=COSV99533736;OCCURENCE=1(upper_aerodigestive_tract)	EEF2K	259	0	404	43	0.0961968680089485	TRUE	TRUE
ENSG00000142765.18	.	BCM	GRCh38.p13	chr1	27351547	27351547	+	C	C	T	Silent	SNP	ENST00000616558.5	exon13	c.C1335T	p.Y445Y	exonic	ENSG00000142765.18	.	synonymous SNV	ENSG00000142765.18:ENST00000616558.5:exon13:c.C1335T:p.Y445Y	1p36.11	C3N-04119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SYTL1	91	0	128	23	0.152317880794702	TRUE	NA
ENSG00000126705.15	.	BCM	GRCh38.p13	chr1	27551243	27551243	+	G	G	A	Silent	SNP	ENST00000673934.1	exon8	c.C873T	p.L291L	exonic	ENSG00000126705.15	.	synonymous SNV	ENSG00000126705.15:ENST00000673934.1:exon8:c.C873T:p.L291L	1p36.11	C3N-04119	1.847e-05	0	0	0	0	1.687e-05	0	6.238e-05	rs758776352	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AHDC1	126	0	250	32	0.113475177304965	TRUE	NA
ENSG00000175077.6	.	BCM	GRCh38.p13	chr3	187199806	187199806	+	C	C	T	Silent	SNP	ENST00000312295.5	exon2	c.C528T	p.H176H	exonic	ENSG00000175077.6	.	synonymous SNV	ENSG00000175077.6:ENST00000312295.5:exon2:c.C528T:p.H176H	3q27.3	C3N-04119	8.601e-06	0	0	0	0	1.572e-05	0	0	rs368637643	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RTP1	148	0	220	14	0.0598290598290598	TRUE	NA
ENSG00000153395.10	.	BCM	GRCh38.p13	chr5	1474026	1474026	+	C	C	T	Silent	SNP	ENST00000283415.4	exon11	c.G1110A	p.A370A	exonic	ENSG00000153395.10	.	synonymous SNV	ENSG00000153395.10:ENST00000283415.4:exon11:c.G1110A:p.A370A	5p15.33	C3N-04119	1.648e-05	0	0	0	0	1.499e-05	0	6.058e-05	rs756860780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99358646;OCCURENCE=1(endometrium)	LPCAT1	316	0	481	56	0.104283054003724	TRUE	NA
ENSG00000145832.14	.	BCM	GRCh38.p13	chr5	135842441	135842441	+	C	C	T	Silent	SNP	ENST00000433282.6	exon2	c.C72T	p.H24H	exonic	ENSG00000145832.14	.	synonymous SNV	ENSG00000145832.14:ENST00000433282.6:exon2:c.C72T:p.H24H	5q31.1	C3N-04119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC25A48	170	0	302	27	0.0820668693009119	TRUE	TRUE
ENSG00000169436.17	.	BCM	GRCh38.p13	chr8	138694826	138694826	+	C	C	T	Silent	SNP	ENST00000303045.11	exon33	c.G2646A	p.P882P	exonic	ENSG00000169436.17	.	synonymous SNV	ENSG00000169436.17:ENST00000303045.11:exon33:c.G2646A:p.P882P	8q24.23	C3N-04119	2.49e-05	0	0	0	0	3.01e-05	0	6.231e-05	rs756859195	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57346815;OCCURENCE=1(large_intestine),1(urinary_tract)	COL22A1	196	0	329	54	0.140992167101828	TRUE	TRUE
ENSG00000109927.10	.	BCM	GRCh38.p13	chr11	121146022	121146022	+	G	G	A	Silent	SNP	ENST00000392793.5	exon12	c.G4011A	p.A1337A	exonic	ENSG00000109927.10	.	synonymous SNV	ENSG00000109927.10:ENST00000392793.5:exon12:c.G4011A:p.A1337A	11q23.3	C3N-04119	0.0018	0.0195	0.0005	0	0	9.229e-05	0.0022	6.083e-05	rs144441070	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50749983;OCCURENCE=1(large_intestine),1(stomach)	TECTA	402	0	611	75	0.10932944606414	TRUE	TRUE
ENSG00000133110.15	.	BCM	GRCh38.p13	chr13	37580644	37580644	+	G	G	A	Silent	SNP	ENST00000379747.9	exon11	c.C1446T	p.N482N	exonic	ENSG00000133110.15	.	synonymous SNV	ENSG00000133110.15:ENST00000379747.9:exon11:c.C1446T:p.N482N	13q13.3	C3N-04119	8.237e-06	9.61e-05	0	0	0	0	0	0	rs147888983	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65713279;OCCURENCE=1(large_intestine),1(central_nervous_system),1(ovary),1(stomach),1(haematopoietic_and_lymphoid_tissue),1(lung)	POSTN	292	0	309	24	0.0720720720720721	TRUE	TRUE
ENSG00000134897.14	.	BCM	GRCh38.p13	chr13	102816529	102816529	+	C	C	A	Silent	SNP	ENST00000257336.6	exon4	c.C580A	p.R194R	exonic	ENSG00000134897.14;ENSG00000270181.3	.	synonymous SNV	ENSG00000134897.14:ENST00000257336.6:exon4:c.C580A:p.R194R,ENSG00000270181.3:ENST00000639435.1:exon4:c.C580A:p.R194R	13q33.1	C3N-04119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BIVM	87	0	83	6	0.0674157303370786	TRUE	NA
ENSG00000169992.10	.	BCM	GRCh38.p13	chr17	7417484	7417484	+	C	C	T	Silent	SNP	ENST00000302926.7	exon7	c.C2193T	p.A731A	exonic	ENSG00000169992.10	.	synonymous SNV	ENSG00000169992.10:ENST00000302926.7:exon7:c.C2193T:p.A731A	17p13.1	C3N-04119	0	0	0	0	0	0	0	0	rs775547220	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NLGN2	76	0	87	13	0.13	TRUE	NA
ENSG00000136488.15	.	BCM	GRCh38.p13	chr17	63895208	63895208	+	G	G	A	Silent	SNP	ENST00000316193.13	exon5	c.C468T	p.D156D	exonic	ENSG00000136488.15	.	synonymous SNV	ENSG00000136488.15:ENST00000316193.13:exon5:c.C468T:p.D156D	17q23.3	C3N-04119	8.358e-06	0	0	0	0	0	0	6.058e-05	rs369347327	3.17	T	T	B	B	.	D	.	D	N	0.169	T	T	D	0.334	.	0.284	.	.	T	T	T	T	T	-0.732	0.037	0.087	N	N	-1.625	0.050	-1.714	0.048	0.001	0.497	0.590	0.547	0.542	.	2.560	-5.120	-2.872	0.214	-1.487	0.000	0.470	0.008	863	.	.	.	ID=COSV60242801;OCCURENCE=1(liver),1(oesophagus),1(skin)	CSH1	506	0	711	81	0.102272727272727	NA	TRUE
ENSG00000198795.11	.	BCM	GRCh38.p13	chr18	25224486	25224486	+	G	G	A	Silent	SNP	ENST00000361524.8	exon4	c.C3432T	p.N1144N	exonic	ENSG00000198795.11	.	synonymous SNV	ENSG00000198795.11:ENST00000361524.8:exon4:c.C3432T:p.N1144N	18q11.2	C3N-04119	.	.	.	.	.	.	.	.	rs1011241462	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64130709;OCCURENCE=1(large_intestine)	ZNF521	189	0	251	35	0.122377622377622	TRUE	TRUE
ENSG00000142303.14	.	BCM	GRCh38.p13	chr19	8605096	8605096	+	C	C	T	Silent	SNP	ENST00000597188.6	exon4	c.G351A	p.A117A	exonic	ENSG00000142303.14	.	synonymous SNV	ENSG00000142303.14:ENST00000597188.6:exon4:c.G351A:p.A117A	19p13.2	C3N-04119	0.0004	0.0051	0	0	0	1.667e-05	0	0	rs114628276	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99547070;OCCURENCE=1(lung)	ADAMTS10	225	0	325	43	0.116847826086957	TRUE	NA
ENSG00000125966.10	.	BCM	GRCh38.p13	chr20	35246947	35246947	+	C	C	T	Silent	SNP	ENST00000246186.8	exon2	c.C354T	p.Y118Y	exonic	ENSG00000125966.10	.	synonymous SNV	ENSG00000125966.10:ENST00000246186.8:exon2:c.C354T:p.Y118Y	20q11.22	C3N-04119	2.484e-05	0	0	0.0001	0	2.997e-05	0	0	rs201429856	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MMP24	276	0	437	53	0.108163265306122	TRUE	NA
ENSG00000149658.18	.	BCM	GRCh38.p13	chr20	63202866	63202866	+	A	A	G	Silent	SNP	ENST00000370339.8	exon4	c.T1074C	p.S358S	exonic	ENSG00000149658.18	.	synonymous SNV	ENSG00000149658.18:ENST00000370339.8:exon4:c.T1074C:p.S358S	20q13.33	C3N-04119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	YTHDF1	319	0	513	61	0.106271777003484	TRUE	TRUE
ENSG00000156299.13	.	BCM	GRCh38.p13	chr21	31245632	31245632	+	G	G	A	Silent	SNP	ENST00000286827.7	exon7	c.C1440T	p.D480D	exonic	ENSG00000156299.13	.	synonymous SNV	ENSG00000156299.13:ENST00000286827.7:exon7:c.C1440T:p.D480D	21q22.11	C3N-04119	9.437e-05	0	0	0.0008	0	3.079e-05	0	0.0001	rs745535556	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54545301;OCCURENCE=1(large_intestine),1(stomach)	TIAM1	69	0	98	16	0.140350877192982	TRUE	TRUE
ENSG00000156299.13	.	BCM	GRCh38.p13	chr21	31266841	31266841	+	C	C	T	Silent	SNP	ENST00000286827.7	exon5	c.G132A	p.S44S	exonic	ENSG00000156299.13	.	synonymous SNV	ENSG00000156299.13:ENST00000286827.7:exon5:c.G132A:p.S44S	21q22.11	C3N-04119	0.0006	0.0002	0.0003	0	0.0018	0.0007	0.0011	0.0002	rs142183230	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TIAM1	269	0	426	33	0.0718954248366013	TRUE	NA
ENSG00000130487.9	.	BCM	GRCh38.p13	chr22	50549126	50549126	+	G	G	T	Silent	SNP	ENST00000395676.4	exon1	c.G960T	p.A320A	exonic	ENSG00000130487.9	.	synonymous SNV	ENSG00000130487.9:ENST00000395676.4:exon1:c.G960T:p.A320A	22q13.33	C3N-04119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KLHDC7B	220	0	326	39	0.106849315068493	TRUE	TRUE
ENSG00000198453.13	.	BCM	GRCh38.p13	chr19	36997123	36997123	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000198453.13;ENSG00000275547.1	dist=44389;dist=27763	.	.	19q13.12	C3N-04119	0.0002	0	0	0.0013	0	0.0002	0	0	rs752008255	2.15	D	D	.	.	.	N	.	T	N	0.160	T	T	T	0.107	0.614	0.473	.	.	T	T	T	T	T	1.755	17.410	0.912	N	N	-1.056	0.347	-1.079	0.398	0.003	0.554	0.574	0.618	0.621	.	3.740	0.165	2.240	0.066	-0.998	0.005	0.001	0.000	662	Zinc_finger_C2H2-type	.	.	.	ZNF568	163	0	167	36	0.177339901477833	TRUE	NA
ENSG00000121904.17	.	BCM	GRCh38.p13	chr1	33541174	33541174	+	C	C	A	Missense_Mutation	SNP	ENST00000373388.6	exon58	c.G8981T	p.C2994F	exonic	ENSG00000121904.17	.	nonsynonymous SNV	ENSG00000121904.17:ENST00000373388.6:exon58:c.G8981T:p.C2994F	1p35.1	C3L-02899	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	D	D	0.958	D	D	D	0.918	0.970	0.925	.	T	T	D	D	D	D	3.969	26.800	0.991	D	D	1.060	15.933	0.954	16.251	1.000	0.615	0.574	0.659	0.564	.	5.580	5.580	7.844	0.947	0.599	1.000	1.000	0.999	416	Sushi/SCR/CCP_domain	.	.	.	CSMD2	156	0	154	24	0.134831460674157	TRUE	TRUE
ENSG00000158859.10	.	BCM	GRCh38.p13	chr1	161196738	161196738	+	C	C	T	Missense_Mutation	SNP	ENST00000367996.6	exon2	c.G776A	p.R259H	exonic	ENSG00000158859.10	.	nonsynonymous SNV	ENSG00000158859.10:ENST00000367996.6:exon2:c.G776A:p.R259H	1q23.3	C3L-02899	.	.	.	.	.	.	.	.	.	6.20	T	D	P	B	N	D	L	D	N	0.098	T	T	T	0.202	.	0.767	0.721	T	T	T	T	D	D	2.683	22.800	0.997	D	N	0.069	2.765	0.225	3.307	1.000	0.757	0.547	0.858	0.662	.	5.090	5.090	3.213	1.023	0.599	0.997	1.000	0.999	404	Peptidase_M12B,_ADAM/reprolysin	.	.	ID=COSV100917463;OCCURENCE=1(lung)	ADAMTS4	415	1	315	42	0.117647058823529	TRUE	NA
ENSG00000143847.15	.	BCM	GRCh38.p13	chr1	203056857	203056857	+	C	C	T	Missense_Mutation	SNP	ENST00000447715.6	exon24	c.C2248T	p.R750C	exonic	ENSG00000143847.15	.	nonsynonymous SNV	ENSG00000143847.15:ENST00000447715.6:exon24:c.C2248T:p.R750C	1q32.1	C3L-02899	8.333e-06	0	0	0	0	0	0	6.099e-05	rs750034692	13.20	D	D	D	D	D	D	M	T	D	0.389	T	T	D	0.205	-	0.702	1.319	T	T	T	T	D	D	3.574	25.000	0.999	D	D	0.472	4.825	0.520	5.347	1.000	0.696	0.695	0.692	0.584	.	5.190	5.190	4.440	1.026	0.597	1.000	1.000	0.997	824	.	.	.	.	PPFIA4	388	0	398	37	0.0850574712643678	TRUE	NA
ENSG00000066032.18	.	BCM	GRCh38.p13	chr2	79909792	79909792	+	A	A	C	Missense_Mutation	SNP	ENST00000402739.8	exon6	c.A1051C	p.N351H	exonic	ENSG00000066032.18	.	nonsynonymous SNV	ENSG00000066032.18:ENST00000402739.8:exon6:c.A1051C:p.N351H	2p12	C3L-02899	.	.	.	.	.	.	.	.	.	9.20	D	T	D	P	N	D	L	T	D	0.449	T	T	D	0.120	0.460	0.556	1.366	D	T	T	T	T	D	3.311	24.200	0.997	D	D	0.557	5.516	0.557	5.726	0.971	0.615	0.574	0.659	0.564	.	5.600	5.600	2.853	1.312	0.691	1.000	1.000	0.995	981	.	.	.	ID=COSV63547281;OCCURENCE=1(ovary),1(soft_tissue),1(prostate),2(upper_aerodigestive_tract),1(endometrium)	CTNNA2	156	4	110	46	0.294871794871795	TRUE	NA
ENSG00000158417.11	.	BCM	GRCh38.p13	chr2	99361371	99361371	+	C	C	-	Nonsense_Mutation	SNP	ENST00000289371.11	exon4	c.470delC	p.S157*	exonic	ENSG00000158417.11	.	stopgain	ENSG00000158417.11:ENST00000289371.11:exon4:c.470delC:p.S157*	2q11.2	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EIF5B	137	0	113	19	0.143939393939394	TRUE	TRUE
ENSG00000163513.19	.	BCM	GRCh38.p13	chr3	30674136	30674136	+	T	T	A	Missense_Mutation	SNP	ENST00000295754.10	exon5	c.T1286A	p.V429D	exonic	ENSG00000163513.19	.	nonsynonymous SNV	ENSG00000163513.19:ENST00000295754.10:exon5:c.T1286A:p.V429D	3p24.1	C3L-02899	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.960	D	D	D	0.902	0.837	0.994	1.884	D	D	D	D	D	D	4.389	31	0.988	D	D	0.966	12.889	0.917	14.498	1.000	0.722	0.590	0.725	0.735	.	6.020	6.020	8.017	1.138	0.663	1.000	0.998	1.000	925	Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	TGFBR2	476	0	338	51	0.131105398457584	TRUE	TRUE
ENSG00000145242.13	.	BCM	GRCh38.p13	chr4	65335991	65335991	+	C	C	A	Missense_Mutation	SNP	ENST00000273854.7	exon16	c.G2793T	p.M931I	exonic	ENSG00000145242.13	.	nonsynonymous SNV	ENSG00000145242.13:ENST00000273854.7:exon16:c.G2793T:p.M931I	4q13.1	C3L-02899	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	N	T	N	0.321	T	T	T	0.153	0.437	0.749	0.257	T	T	T	T	T	D	1.626	16.540	0.737	D	N	-0.296	1.625	-0.019	2.296	0.178	0.554	0.574	0.574	0.621	.	6.170	6.170	0.987	1.008	0.599	1.000	0.997	0.984	953	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	EPHA5	151	0	116	21	0.153284671532847	TRUE	TRUE
ENSG00000003147.19	.	BCM	GRCh38.p13	chr7	8232613	8232613	+	C	C	T	Missense_Mutation	SNP	ENST00000402384.8	exon3	c.G160A	p.A54T	exonic	ENSG00000003147.19	.	nonsynonymous SNV	ENSG00000003147.19:ENST00000402384.8:exon3:c.G160A:p.A54T	7p21.3	C3L-02899	1.778e-05	0	0	0.0001	0	0	0	6.921e-05	rs766630394	17.20	D	D	D	D	D	D	M	T	D	0.508	D	D	D	0.513	0.530	0.896	0.164	T	D	T	D	D	D	3.275	24.100	0.999	D	D	0.663	6.635	0.629	6.612	1.000	0.732	0.588	0.744	0.714	.	5.750	5.750	3.900	1.026	0.599	0.999	0.947	0.576	955	Arfaptin_homology_(AH)_domain	.	.	.	ICA1	74	0	84	14	0.142857142857143	TRUE	NA
ENSG00000164776.9	.	BCM	GRCh38.p13	chr7	56081196	56081196	+	C	C	T	Missense_Mutation	SNP	ENST00000297373.6	exon10	c.G1022A	p.R341Q	exonic	ENSG00000164776.9	.	nonsynonymous SNV	ENSG00000164776.9:ENST00000297373.6:exon10:c.G1022A:p.R341Q	7p11.2	C3L-02899	2.486e-05	0	0	0	0	4.531e-05	0	0	rs763494578	6.20	D	D	D	P	N	D	L	T	N	0.355	T	T	T	0.073	0.464	0.720	0.251	T	T	T	T	T	D	3.800	25.800	0.999	D	N	0.082	2.815	0.064	2.593	0.266	0.660	0.380	0.696	0.528	.	5.020	1.720	2.690	1.026	0.599	1.000	1.000	0.992	629	.	.	.	ID=COSV51914856;OCCURENCE=3(large_intestine)	PHKG1	615	0	511	73	0.125	NA	TRUE
ENSG00000204983.14	.	BCM	GRCh38.p13	chr7	142751979	142751979	+	G	G	A	Missense_Mutation	SNP	ENST00000311737.12	exon3	c.G406A	p.G136S	exonic	ENSG00000204983.14	.	nonsynonymous SNV	ENSG00000204983.14:ENST00000311737.12:exon3:c.G406A:p.G136S	7q34	C3L-02899	.	.	.	.	.	.	.	.	.	15.19	D	D	P	B	D	D	L	D	D	0.921	D	D	D	0.811	0.734	0.957	0.343	T	D	D	D	D	.	2.987	23.400	0.997	D	D	0.141	3.050	0.075	2.635	1.000	0.447	0.563	0.547	0.530	.	3.280	3.280	9.674	1.076	0.504	1.000	0.002	0.002	776	Serine_proteases,_trypsin_domain	.	.	.	PRSS1	465	0	412	48	0.104347826086957	TRUE	TRUE
ENSG00000036565.15	.	BCM	GRCh38.p13	chr8	20179349	20179356	+	TTGTTGAA	TTGTTGAA	-	Frame_Shift_Del	DEL	ENST00000276373.10	exon3	c.253_260del	p.F85Qfs*6	exonic	ENSG00000036565.15	.	frameshift deletion	ENSG00000036565.15:ENST00000276373.10:exon3:c.253_260del:p.F85Qfs*6	8p21.3	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC18A1	372	0	325	24	0.0687679083094556	TRUE	TRUE
ENSG00000197444.10	.	BCM	GRCh38.p13	chr10	49738235	49738235	+	C	C	T	Missense_Mutation	SNP	ENST00000374103.9	exon18	c.G2347A	p.E783K	exonic	ENSG00000197444.10	.	nonsynonymous SNV	ENSG00000197444.10:ENST00000374103.9:exon18:c.G2347A:p.E783K	10q11.23	C3L-02899	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.992	D	D	D	0.882	0.911	0.923	0.757	D	D	D	D	D	D	3.755	25.600	0.999	D	D	0.840	9.609	0.659	7.043	1.000	0.696	0.844	0.723	0.568	.	4.840	3.870	6.112	1.012	0.583	1.000	0.504	0.302	900	Transketolase-like,_pyrimidine-binding_domain	.	.	ID=COSV100934495;OCCURENCE=1(skin)	OGDHL	292	0	246	35	0.124555160142349	TRUE	NA
ENSG00000122863.6	.	BCM	GRCh38.p13	chr10	72008425	72008425	+	G	G	A	Missense_Mutation	SNP	ENST00000373115.5	exon3	c.G1394A	p.R465H	exonic	ENSG00000122863.6	.	nonsynonymous SNV	ENSG00000122863.6:ENST00000373115.5:exon3:c.G1394A:p.R465H	10q22.1	C3L-02899	.	.	.	.	.	.	.	.	rs569940449	14.20	T	T	D	D	D	D	M	D	N	0.304	D	D	D	0.510	0.420	0.994	1.857	T	T	D	D	D	D	3.231	23.900	0.999	D	N	0.536	5.330	0.529	5.434	1.000	0.646	0.547	0.645	0.636	.	5.270	5.270	2.423	1.176	0.676	1.000	0.946	0.738	724	.	.	.	.	CHST3	168	0	129	25	0.162337662337662	TRUE	NA
ENSG00000065613.15	.	BCM	GRCh38.p13	chr10	104008235	104008235	+	C	C	A	Missense_Mutation	SNP	ENST00000369755.4	exon12	c.C2663A	p.T888N	exonic	ENSG00000065613.15	.	nonsynonymous SNV	ENSG00000065613.15:ENST00000369755.4:exon12:c.C2663A:p.T888N	10q25.1	C3L-02899	.	.	.	.	.	.	.	.	.	10.20	T	T	D	D	D	D	M	T	N	0.717	T	T	T	0.204	0.264	0.557	1.854	D	T	T	T	D	D	3.549	24.900	0.995	D	D	0.769	8.209	0.774	9.391	1.000	0.732	0.744	0.710	0.714	.	5.940	5.940	6.081	1.026	0.599	1.000	0.966	0.973	59	UVR_domain	.	.	.	SLK	197	0	177	30	0.144927536231884	TRUE	TRUE
ENSG00000151067.22	.	BCM	GRCh38.p13	chr12	2691038	2691038	+	G	G	A	Missense_Mutation	SNP	ENST00000399655.6	exon47	c.G6256A	p.A2086T	exonic	ENSG00000151067.22	.	nonsynonymous SNV	ENSG00000151067.22:ENST00000399655.6:exon47:c.G6256A:p.A2086T	12p13.33	C3L-02899	1.601e-05	0	0	0	0	2.944e-05	0	0	rs763324710	1.18	T	T	B	B	N	D	.	T	N	0.118	T	T	T	0.036	.	0.438	0.184	T	T	T	T	T	.	0.872	10.140	0.960	N	N	-0.739	0.748	-0.671	0.942	1.000	0.496	0.492	0.240	0.555	.	4.490	-0.671	0.245	1.160	0.599	0.001	0.977	0.989	861	Voltage-gated_calcium_channel_subunit_alpha,_C-terminal	.	.	.	CACNA1C	347	0	313	38	0.108262108262108	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-02899	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	317	0	345	49	0.124365482233503	TRUE	TRUE
ENSG00000139620.13	.	BCM	GRCh38.p13	chr12	48660588	48660588	+	G	G	C	Missense_Mutation	SNP	ENST00000420613.7	exon8	c.C1005G	p.F335L	exonic	ENSG00000139620.13	.	nonsynonymous SNV	ENSG00000139620.13:ENST00000420613.7:exon8:c.C1005G:p.F335L	12q13.11	C3L-02899	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.979	T	T	D	0.579	0.831	0.741	1.206	T	T	D	D	D	D	3.948	26.600	0.999	D	N	0.700	7.119	0.676	7.319	0.996	0.707	0.702	0.725	0.714	.	5.640	5.640	2.699	1.172	0.614	1.000	1.000	0.995	363	Potential_DNA-binding_domain	.	.	.	KANSL2	295	0	200	28	0.12280701754386	TRUE	TRUE
ENSG00000176219.3	.	BCM	GRCh38.p13	chr14	20224659	20224659	+	A	A	T	Missense_Mutation	SNP	ENST00000315519.3	exon1	c.A950T	p.D317V	exonic	ENSG00000176219.3	.	nonsynonymous SNV	ENSG00000176219.3:ENST00000315519.3:exon1:c.A950T:p.D317V	14q11.2	C3L-02899	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	D	N	T	N	0.171	T	T	T	0.042	0.356	0.365	0.079	T	T	T	T	T	T	1.410	15.150	0.651	N	N	-0.809	0.642	-0.707	0.890	0.081	0.487	0.574	0.574	0.564	.	5.100	2.640	0.053	1.286	0.652	0.000	0.997	0.634	964	.	.	.	.	OR11H6	128	0	76	13	0.146067415730337	TRUE	TRUE
ENSG00000100813.14	.	BCM	GRCh38.p13	chr14	23078248	23078248	+	C	C	A	Nonsense_Mutation	SNP	ENST00000262710.5	exon8	c.G2200T	p.E734X	exonic	ENSG00000100813.14	.	stopgain	ENSG00000100813.14:ENST00000262710.5:exon8:c.G2200T:p.E734X	14q11.2	C3L-02899	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.364	.	.	.	.	.	.	.	.	.	D	D	.	.	8.097	41	0.995	D	N	1.027	14.790	0.892	13.394	1.000	0.707	0.702	0.725	0.635	.	5.990	5.100	2.193	1.026	0.599	1.000	1.000	1.000	807	.	.	.	.	ACIN1	278	1	265	43	0.13961038961039	TRUE	TRUE
ENSG00000100934.15	.	BCM	GRCh38.p13	chr14	39042866	39042866	+	G	G	A	Missense_Mutation	SNP	ENST00000307712.11	exon17	c.C1906T	p.L636F	exonic	ENSG00000100934.15	.	nonsynonymous SNV	ENSG00000100934.15:ENST00000307712.11:exon17:c.C1906T:p.L636F	14q21.1	C3L-02899	0.0002	0	8.639e-05	0	0	0.0003	0	0	rs144656181	12.20	D	D	B	B	D	D	M	T	D	0.628	T	T	D	0.224	.	0.782	1.103	D	T	T	T	D	D	3.763	25.700	0.999	D	D	0.340	3.994	0.376	4.193	0.672	0.732	0.744	0.744	0.714	.	5.550	4.660	5.717	1.176	0.676	1.000	0.999	0.947	853	Gelsolin-like_domain;Sec23,_C-terminal	.	.	.	SEC23A	331	0	344	48	0.122448979591837	TRUE	NA
ENSG00000182400.15	.	BCM	GRCh38.p13	chr14	39151826	39151826	+	G	G	A	Missense_Mutation	SNP	ENST00000330149.10	exon5	c.C365T	p.T122M	exonic	ENSG00000182400.15	.	nonsynonymous SNV	ENSG00000182400.15:ENST00000330149.10:exon5:c.C365T:p.T122M	14q21.1	C3L-02899	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	D	D	M	T	D	0.783	T	T	D	0.456	0.567	0.587	0.490	T	T	D	T	D	D	4.630	32	0.999	D	D	0.841	9.643	0.807	10.343	1.000	0.732	0.744	0.710	0.728	.	5.960	5.070	7.553	1.163	0.676	1.000	1.000	0.997	840	.	.	.	.	TRAPPC6B	135	0	157	20	0.112994350282486	TRUE	NA
ENSG00000028528.15	.	BCM	GRCh38.p13	chr15	64127237	64127237	+	G	G	A	Missense_Mutation	SNP	ENST00000559844.6	exon7	c.G716A	p.R239K	exonic	ENSG00000028528.15	.	nonsynonymous SNV	ENSG00000028528.15:ENST00000559844.6:exon7:c.G716A:p.R239K	15q22.31	C3L-02899	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.912	T	T	T	0.437	0.705	0.657	0.795	D	D	D	D	D	D	4.181	28.500	0.997	D	D	0.913	11.390	0.867	12.399	1.000	0.732	0.725	0.744	0.714	.	4.970	4.970	9.529	1.176	0.676	1.000	0.992	0.983	307	Phox_homologous_domain;Sorting_Nexin_1,_PX_domain	.	.	.	SNX1	187	0	155	22	0.124293785310734	TRUE	TRUE
ENSG00000172824.16	.	BCM	GRCh38.p13	chr16	67000911	67000911	+	G	G	C	Missense_Mutation	SNP	ENST00000648724.2	exon4	c.G457C	p.E153Q	exonic	ENSG00000172824.16	.	nonsynonymous SNV	ENSG00000172824.16:ENST00000648724.2:exon4:c.G457C:p.E153Q	16q22.1	C3L-02899	.	.	.	.	.	.	.	.	.	7.19	D	D	P	P	N	N	N	T	N	0.239	T	T	D	0.235	0.705	0.804	0.218	T	.	T	T	D	D	2.316	21.700	0.996	D	D	-0.023	2.429	-0.014	2.310	1.000	0.658	0.707	0.504	0.604	.	4.880	3.910	1.632	0.044	0.657	0.859	0.002	0.005	164	Carboxylesterase,_type_B	.	.	.	CES4A	421	1	364	64	0.149532710280374	TRUE	TRUE
ENSG00000173826.14	.	BCM	GRCh38.p13	chr17	63524198	63524198	+	G	G	A	Missense_Mutation	SNP	ENST00000583023.1	exon2	c.G136A	p.D46N	exonic	ENSG00000173826.14	.	nonsynonymous SNV	ENSG00000173826.14:ENST00000583023.1:exon2:c.G136A:p.D46N	17q23.3	C3L-02899	1.647e-05	0.0002	0	0	0	0	0	0	rs368030494	18.20	D	D	D	D	D	D	M	D	D	0.636	D	D	D	0.756	.	0.889	0.669	T	D	T	D	D	D	4.117	27.900	0.938	D	D	0.577	5.702	0.541	5.557	1.000	0.677	0.590	0.673	0.605	.	5.340	5.340	9.942	1.176	0.676	1.000	0.989	0.945	809	PAS_domain	.	.	ID=COSV59001631;OCCURENCE=1(large_intestine),2(skin)	KCNH6	425	0	530	31	0.0552584670231729	TRUE	TRUE
ENSG00000105404.11	.	BCM	GRCh38.p13	chr19	41959259	41959259	+	C	C	A	Nonsense_Mutation	SNP	ENST00000222008.11	exon1	c.G34T	p.E12X	exonic	ENSG00000105404.11	.	stopgain	ENSG00000105404.11:ENST00000222008.11:exon1:c.G34T:p.E12X	19q13.2	C3L-02899	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	A	.	.	.	0.669	.	.	.	.	.	.	.	.	.	D	D	.	.	7.480	38	0.997	N	N	0.564	5.574	0.332	3.910	1.000	0.442	0.522	0.522	0.562	.	4.170	3.120	1.584	1.022	0.596	0.040	0.997	0.988	846	.	.	.	.	RABAC1	458	0	366	46	0.111650485436893	TRUE	TRUE
ENSG00000160505.16	.	BCM	GRCh38.p13	chr19	55861542	55861542	+	G	G	C	Missense_Mutation	SNP	ENST00000301295.11	exon4	c.G2013C	p.K671N	exonic	ENSG00000160505.16	.	nonsynonymous SNV	ENSG00000160505.16:ENST00000301295.11:exon4:c.G2013C:p.K671N	19q13.43	C3L-02899	.	.	.	.	.	.	.	.	.	3.19	T	D	B	B	.	N	N	D	D	0.104	T	T	T	0.118	0.389	0.549	0.049	T	T	T	T	T	T	0.227	3.433	0.867	N	N	-1.363	0.133	-1.481	0.115	0.001	0.554	0.588	0.574	0.564	.	4.490	-6.220	-2.000	-0.434	-0.154	0.000	0.000	0.001	900	.	.	.	.	NLRP4	107	0	92	11	0.106796116504854	TRUE	TRUE
ENSG00000175556.17	.	BCM	GRCh38.p13	chrX	119009172	119009172	+	T	T	G	Missense_Mutation	SNP	ENST00000371628.8	exon7	c.T1577G	p.L526R	exonic	ENSG00000175556.17	.	nonsynonymous SNV	ENSG00000175556.17:ENST00000371628.8:exon7:c.T1577G:p.L526R	Xq24	C3L-02899	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	N	N	M	T	D	0.902	T	T	D	0.475	0.711	0.678	2.691	T	T	D	D	D	D	3.956	26.700	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	6.080	6.080	7.927	1.134	0.661	0.993	0.995	0.993	341	.	.	.	.	LONRF3	105	1	89	18	0.168224299065421	TRUE	TRUE
ENSG00000142606.16	.	BCM	GRCh38.p13	chr1	2592968	2592968	+	T	T	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000142606.16	ENST00000378412.8:exon20:c.1868-2A>T	.	.	1p36.32	C3L-02899	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.724	34	0.994	D	.	1.032	14.957	0.860	12.140	1.000	0.116	0.061	0.074	0.110	0.897	4.760	4.760	7.746	1.138	0.665	1.000	0.996	0.936	835	.	.	.	.	MMEL1	148	0	124	10	0.0746268656716418	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673609	7673609	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon9:c.920-1G>T	.	.	17p13.1	C3L-02899	.	.	.	.	.	.	.	.	.	3.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.070	33	0.989	N	.	0.655	6.536	0.401	4.363	0.991	0.284	0.279	0.341	0.120	0.809	4.710	4.710	1.455	1.022	0.596	1.000	0.691	0.574	435	.	.	.	ID=COSV52664150;OCCURENCE=8(breast),6(liver),3(oesophagus),1(large_intestine),2(biliary_tract),1(stomach),1(skin),1(prostate),3(lung),1(upper_aerodigestive_tract)	TP53	435	0	283	46	0.139817629179331	TRUE	TRUE
ENSG00000163531.15	.	BCM	GRCh38.p13	chr1	204970635	204970635	+	C	C	T	Silent	SNP	ENST00000339876.10	exon11	c.C1023T	p.D341D	exonic	ENSG00000163531.15	.	synonymous SNV	ENSG00000163531.15:ENST00000339876.10:exon11:c.C1023T:p.D341D	1q32.1	C3L-02899	0.0061	0.0670	0.0022	0.0001	0	0.0001	0.0022	0.0003	rs6690894	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NFASC	257	0	215	26	0.107883817427386	TRUE	NA
ENSG00000144406.19	.	BCM	GRCh38.p13	chr2	209839222	209839222	+	C	C	T	Silent	SNP	ENST00000439458.5	exon19	c.C3042T	p.H1014H	exonic	ENSG00000144406.19	.	synonymous SNV	ENSG00000144406.19:ENST00000439458.5:exon19:c.C3042T:p.H1014H	2q34	C3L-02899	4.796e-05	0.0005	0	0	0	0	0	0	rs572393115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99779565;OCCURENCE=1(large_intestine)	UNC80	178	0	124	24	0.162162162162162	TRUE	NA
ENSG00000232382.2	.	BCM	GRCh38.p13	chr3	98470044	98470044	+	C	C	T	Silent	SNP	ENST00000642057.1	exon2	c.C468T	p.S156S	exonic	ENSG00000232382.2	.	synonymous SNV	ENSG00000232382.2:ENST00000642057.1:exon2:c.C468T:p.S156S	3q11.2	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR5K1	426	0	410	25	0.0574712643678161	NA	TRUE
ENSG00000204967.12	.	BCM	GRCh38.p13	chr5	140807208	140807208	+	C	C	T	Silent	SNP	ENST00000530339.2	exon1	c.C21T	p.S7S	exonic	ENSG00000204967.12	.	synonymous SNV	ENSG00000204967.12:ENST00000530339.2:exon1:c.C21T:p.S7S	5q31.3	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHA4	256	0	162	13	0.0742857142857143	TRUE	TRUE
ENSG00000147647.13	.	BCM	GRCh38.p13	chr8	104466891	104466891	+	G	G	A	Silent	SNP	ENST00000351513.7	exon1	c.C30T	p.R10R	exonic	ENSG00000147647.13	.	synonymous SNV	ENSG00000147647.13:ENST00000351513.7:exon1:c.C30T:p.R10R	8q22.3	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100680171;OCCURENCE=1(stomach)	DPYS	215	0	203	14	0.0645161290322581	TRUE	TRUE
ENSG00000165238.16	.	BCM	GRCh38.p13	chr9	93259149	93259149	+	G	G	A	Silent	SNP	ENST00000297954.8	exon11	c.G2601A	p.A867A	exonic	ENSG00000165238.16	.	synonymous SNV	ENSG00000165238.16:ENST00000297954.8:exon11:c.G2601A:p.A867A	9q22.31	C3L-02899	0.0002	0	0.0002	0	0	0.0003	0	0.0002	rs375757039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99944434;OCCURENCE=1(stomach)	WNK2	236	0	200	32	0.137931034482759	TRUE	NA
ENSG00000110713.17	.	BCM	GRCh38.p13	chr11	3691445	3691445	+	C	C	T	Silent	SNP	ENST00000359171.8	exon28	c.G4407A	p.S1469S	exonic	ENSG00000110713.17	.	synonymous SNV	ENSG00000110713.17:ENST00000359171.8:exon28:c.G4407A:p.S1469S	11p15.4	C3L-02899	5.768e-05	9.61e-05	0	0	0	1.499e-05	0	0.0003	rs373056120	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NUP98	314	0	352	46	0.115577889447236	TRUE	NA
ENSG00000141447.18	.	BCM	GRCh38.p13	chr18	24178174	24178174	+	G	G	A	Silent	SNP	ENST00000319481.8	exon21	c.C1932T	p.L644L	exonic	ENSG00000141447.18	.	synonymous SNV	ENSG00000141447.18:ENST00000319481.8:exon21:c.C1932T:p.L644L	18q11.2	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OSBPL1A	95	0	90	11	0.108910891089109	TRUE	TRUE
ENSG00000010310.9	.	BCM	GRCh38.p13	chr19	45677050	45677050	+	G	G	A	Silent	SNP	ENST00000590918.6	exon8	c.G735A	p.L245L	exonic	ENSG00000010310.9	.	synonymous SNV	ENSG00000010310.9:ENST00000590918.6:exon8:c.G735A:p.L245L	19q13.32	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GIPR	607	1	554	66	0.106451612903226	TRUE	TRUE
ENSG00000063244.12	.	BCM	GRCh38.p13	chr19	55655143	55655143	+	G	G	A	Silent	SNP	ENST00000308924.8	exon1	c.G39A	p.E13E	exonic	ENSG00000063244.12	.	synonymous SNV	ENSG00000063244.12:ENST00000308924.8:exon1:c.G39A:p.E13E	19q13.42	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	U2AF2	373	0	317	51	0.138586956521739	TRUE	NA
ENSG00000125931.11	.	BCM	GRCh38.p13	chrX	72301831	72301831	+	C	C	T	Silent	SNP	ENST00000651998.1	exon3	c.G474A	p.L158L	exonic	ENSG00000125931.11;ENSG00000285547.1	.	synonymous SNV	ENSG00000125931.11:ENST00000651998.1:exon3:c.G474A:p.L158L,ENSG00000285547.1:ENST00000648922.1:exon12:c.G1650A:p.L550L	Xq13.1	C3L-02899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CITED1	217	0	143	36	0.201117318435754	TRUE	NA
ENSG00000174776.11	.	BCM	GRCh38.p13	chr3	167566877	167566877	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000174776.11	.	.	.	3q26.1	C3L-02899	8.225e-05	0.0018	0	0	0	0	0	0	rs552286041	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57701437;OCCURENCE=1(large_intestine),1(pancreas)	WDR49	125	0	132	10	0.0704225352112676	TRUE	NA
ENSG00000157423.18	.	BCM	GRCh38.p13	chr16	71175828	71175828	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000157423.18	.	.	.	16q22.2	C3L-02899	0.0160	0.0029	0.0087	0	0.0438	0.0223	0.0199	0.0009	rs12933249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HYDIN	194	0	151	13	0.0792682926829268	TRUE	NA
ENSG00000188157.15	.	BCM	GRCh38.p13	chr1	1041627	1041628	+	TG	TG	-	Frame_Shift_Del	DEL	ENST00000379370.7	exon6	c.1102_1103del	p.V369Hfs*53	exonic	ENSG00000188157.15	.	frameshift deletion	ENSG00000188157.15:ENST00000379370.7:exon6:c.1102_1103del:p.V369Hfs*53	1p36.33	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AGRN	264	0	385	31	0.0745192307692308	TRUE	TRUE
ENSG00000159339.13	.	BCM	GRCh38.p13	chr1	17331024	17331024	+	G	G	A	Missense_Mutation	SNP	ENST00000375448.4	exon2	c.G148A	p.V50M	exonic	ENSG00000159339.13	.	nonsynonymous SNV	ENSG00000159339.13:ENST00000375448.4:exon2:c.G148A:p.V50M	1p36.13	C3N-02971	4.123e-05	0	0	0	0	6.003e-05	0	6.058e-05	rs757370203	6.19	D	D	D	P	N	N	M	T	N	0.498	T	T	D	0.179	.	0.250	0.503	T	T	T	T	D	.	2.049	19.630	0.997	N	N	0.094	2.861	-0.096	2.059	0.107	0.554	0.610	0.618	0.542	.	5.320	4.170	0.351	0.228	-0.113	0.029	0.002	0.001	632	Protein-arginine_deiminase_(PAD)_N-terminal	.	.	ID=COSV100966759;OCCURENCE=1(central_nervous_system)	PADI4	150	0	252	15	0.0561797752808989	TRUE	NA
ENSG00000198758.10	.	BCM	GRCh38.p13	chr1	109757857	109757857	+	G	G	A	Missense_Mutation	SNP	ENST00000361965.8	exon10	c.C839T	p.T280I	exonic	ENSG00000198758.10	.	nonsynonymous SNV	ENSG00000198758.10:ENST00000361965.8:exon10:c.C839T:p.T280I	1p13.3	C3N-02971	.	.	.	.	.	.	.	.	.	4.20	D	T	D	P	N	N	L	T	D	0.505	T	T	T	0.121	0.377	0.751	0.452	T	T	T	T	D	T	2.627	22.700	0.995	N	N	-0.291	1.635	-0.367	1.432	0.954	0.428	0.547	0.547	0.613	.	5.310	3.410	3.860	1.176	0.676	0.256	0.004	0.005	563	.	.	.	.	EPS8L3	254	0	443	40	0.082815734989648	TRUE	TRUE
ENSG00000168679.18	.	BCM	GRCh38.p13	chr1	110381655	110381655	+	G	G	C	Missense_Mutation	SNP	ENST00000369779.9	exon4	c.C361G	p.P121A	exonic	ENSG00000168679.18	.	nonsynonymous SNV	ENSG00000168679.18:ENST00000369779.9:exon4:c.C361G:p.P121A	1p13.3	C3N-02971	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	N	D	L	T	N	0.304	T	T	T	0.057	0.499	0.681	0.157	T	T	T	T	T	T	1.213	13.740	0.200	D	N	-0.526	1.127	-0.432	1.316	1.000	0.421	0.551	0.545	0.492	.	4.870	1.780	2.444	0.194	-0.154	1.000	0.997	0.766	883	Major_facilitator_superfamily_domain	.	.	.	SLC16A4	75	0	138	15	0.0980392156862745	TRUE	TRUE
ENSG00000198965.4	.	BCM	GRCh38.p13	chr1	158480398	158480398	+	T	T	G	Missense_Mutation	SNP	ENST00000368152.1	exon1	c.T521G	p.L174W	exonic	ENSG00000198965.4	.	nonsynonymous SNV	ENSG00000198965.4:ENST00000368152.1:exon1:c.T521G:p.L174W	1q23.1	C3N-02971	.	.	.	.	.	.	.	.	.	7.19	D	D	D	D	.	N	M	T	D	0.466	T	T	T	0.174	0.532	0.755	0.068	T	T	T	T	D	T	2.452	22.300	0.955	N	N	0.123	2.978	-0.115	2.005	0.046	0.603	0.549	0.574	0.564	.	4.480	3.350	3.094	0.949	0.643	0.140	0.001	0.250	672	GPCR,_rhodopsin-like,_7TM	.	.	.	OR10R2	225	0	435	23	0.0502183406113537	TRUE	NA
ENSG00000162896.6	.	BCM	GRCh38.p13	chr1	206935637	206935637	+	G	G	T	Nonsense_Mutation	SNP	ENST00000356495.5	exon5	c.C1227A	p.Y409X	exonic	ENSG00000162896.6	.	stopgain	ENSG00000162896.6:ENST00000356495.5:exon5:c.C1227A:p.Y409X	1q32.1	C3N-02971	.	.	.	.	.	.	.	.	.	1.6	.	.	.	.	N	A	.	.	.	0.829	.	.	.	.	.	.	.	.	.	T	T	.	.	3.181	23.800	0.921	N	N	-0.914	0.503	-1.318	0.198	1.000	0.520	0.596	0.441	0.636	.	5.450	-7.050	-2.122	-3.255	-1.484	0.000	0.000	0.002	798	Immunoglobulin_V-set_domain;Immunoglobulin_subtype	.	.	.	PIGR	322	0	556	84	0.13125	TRUE	TRUE
ENSG00000279263.1	.	BCM	GRCh38.p13	chr1	247949363	247949363	+	G	G	A	Missense_Mutation	SNP	ENST00000623922.1	exon1	c.G506A	p.R169Q	exonic	ENSG00000279263.1	.	nonsynonymous SNV	ENSG00000279263.1:ENST00000623922.1:exon1:c.G506A:p.R169Q	1q44	C3N-02971	9.89e-05	0.0004	8.678e-05	0.0003	0	5.995e-05	0	0	rs565612069	0.16	.	.	B	B	N	N	L	.	.	.	T	T	T	0.048	.	.	.	T	T	T	T	T	T	0.272	3.965	0.986	N	N	-0.736	0.753	-0.737	0.846	0.000	0.487	0.574	0.574	0.564	.	1.790	0.818	0.234	-2.356	-0.206	0.000	0.000	0.000	946	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV61727112;OCCURENCE=2(central_nervous_system),1(skin)	OR2L8	300	0	462	55	0.106382978723404	NA	TRUE
ENSG00000188687.17	.	BCM	GRCh38.p13	chr2	74239463	74239463	+	G	G	A	Missense_Mutation	SNP	ENST00000346834.8	exon18	c.C2191T	p.R731C	exonic	ENSG00000188687.17	.	nonsynonymous SNV	ENSG00000188687.17:ENST00000346834.8:exon18:c.C2191T:p.R731C	2p13.1	C3N-02971	1.663e-05	0	0	0	0.0002	1.508e-05	0	0	.	10.20	D	D	D	P	N	D	L	T	D	0.470	T	T	D	0.406	0.384	0.628	0.742	T	D	T	T	D	D	3.855	26.100	0.999	D	N	0.189	3.257	0.198	3.171	0.004	0.554	0.588	0.574	0.530	.	5.330	2.370	1.393	1.176	0.676	0.991	0.965	0.965	649	Bicarbonate_transporter,_C-terminal	.	.	ID=COSV61030120;OCCURENCE=1(large_intestine),1(stomach)	SLC4A5	304	0	557	46	0.0762852404643449	TRUE	TRUE
ENSG00000132313.15	.	BCM	GRCh38.p13	chr2	86206174	86206174	+	A	A	G	Missense_Mutation	SNP	ENST00000337109.9	exon2	c.A112G	p.I38V	exonic	ENSG00000132313.15	.	nonsynonymous SNV	ENSG00000132313.15:ENST00000337109.9:exon2:c.A112G:p.I38V	2p11.2	C3N-02971	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.038	T	T	T	0.025	0.171	0.102	0.113	T	T	T	T	T	T	0.285	4.117	0.776	N	N	-0.946	0.465	-0.926	0.585	0.999	0.732	0.744	0.710	0.714	.	5.290	-1.240	0.127	1.302	0.747	0.004	0.968	0.934	475	.	.	.	.	MRPL35	139	0	268	18	0.0629370629370629	NA	TRUE
ENSG00000144057.15	.	BCM	GRCh38.p13	chr2	106830159	106830159	+	G	G	T	Missense_Mutation	SNP	ENST00000409382.7	exon5	c.C1225A	p.L409I	exonic	ENSG00000144057.15	.	nonsynonymous SNV	ENSG00000144057.15:ENST00000409382.7:exon5:c.C1225A:p.L409I	2q12.3	C3N-02971	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	M	T	N	0.614	T	T	T	0.253	0.657	0.450	1.457	T	T	T	T	D	D	3.578	25.000	0.997	D	D	0.865	10.197	0.892	13.426	1.000	0.563	0.574	0.609	0.564	.	6.060	6.060	9.964	1.176	0.676	1.000	1.000	1.000	866	.	.	.	ID=COSV62416335;OCCURENCE=2(large_intestine)	ST6GAL2	117	1	240	35	0.127272727272727	TRUE	TRUE
ENSG00000144228.9	.	BCM	GRCh38.p13	chr2	138550505	138550505	+	A	A	G	Missense_Mutation	SNP	ENST00000280098.9	exon3	c.A101G	p.Y34C	exonic	ENSG00000144228.9	.	nonsynonymous SNV	ENSG00000144228.9:ENST00000280098.9:exon3:c.A101G:p.Y34C	2q22.1	C3N-02971	8.302e-06	0	0	0	0	0	0	6.083e-05	rs770111475	16.20	D	D	D	D	D	D	M	T	D	0.865	T	T	D	0.814	0.710	0.879	0.766	D	T	D	D	D	D	3.932	26.500	0.998	D	D	0.707	7.216	0.657	7.025	1.000	0.651	0.709	0.659	0.655	.	4.720	4.720	7.488	1.311	0.756	1.000	1.000	0.990	890	MATH/TRAF_domain	.	.	.	SPOPL	45	0	102	15	0.128205128205128	TRUE	NA
ENSG00000038295.8	.	BCM	GRCh38.p13	chr4	166003399	166003399	+	C	C	T	Missense_Mutation	SNP	ENST00000061240.7	exon6	c.C641T	p.S214F	exonic	ENSG00000038295.8	.	nonsynonymous SNV	ENSG00000038295.8:ENST00000061240.7:exon6:c.C641T:p.S214F	4q32.3	C3N-02971	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	U	D	H	T	D	0.982	D	D	D	0.897	0.920	0.912	0.941	D	D	D	D	D	D	4.060	27.400	0.998	D	D	0.965	12.852	0.833	11.159	1.000	0.638	0.574	0.618	0.668	.	5.190	5.190	7.905	1.000	0.599	1.000	1.000	0.973	906	Peptidase,_metallopeptidase;Peptidase_M12A;Tolloid/BMP1_peptidase_domain	.	.	ID=COSV99288636;OCCURENCE=1(skin)	TLL1	310	0	431	38	0.0810234541577825	TRUE	TRUE
ENSG00000164292.13	.	BCM	GRCh38.p13	chr5	95793149	95793149	+	G	G	A	Missense_Mutation	SNP	ENST00000379982.8	exon12	c.G1811A	p.R604Q	exonic	ENSG00000164292.13	.	nonsynonymous SNV	ENSG00000164292.13:ENST00000379982.8:exon12:c.G1811A:p.R604Q	5q15	C3N-02971	0.0003	0.0003	0.0025	0	0	0	0	0	rs374462478	3.20	T	T	B	B	D	D	L	T	N	0.217	T	T	T	0.132	.	0.718	0.470	T	T	T	T	T	T	2.633	22.700	0.998	D	N	-0.027	2.418	0.223	3.299	1.000	0.732	0.654	0.659	0.728	.	6.170	6.170	4.094	1.176	0.676	1.000	1.000	0.997	857	.	.	.	.	RHOBTB3	97	0	213	22	0.0936170212765957	TRUE	NA
ENSG00000204655.12	.	BCM	GRCh38.p13	chr6	29659438	29659438	+	C	C	T	Missense_Mutation	SNP	ENST00000376917.8	exon2	c.C208T	p.R70C	exonic	ENSG00000204655.12	.	nonsynonymous SNV	ENSG00000204655.12:ENST00000376917.8:exon2:c.C208T:p.R70C	6p22.1	C3N-02971	3.442e-05	0	0	0	0	3.158e-05	0	0.0001	rs749783831	15.20	D	D	D	D	D	D	M	T	D	0.846	T	T	D	0.720	0.713	0.884	1.024	T	D	D	D	D	D	3.865	26.200	0.999	D	N	0.562	5.559	0.485	5.021	0.998	0.554	0.547	0.602	0.530	.	5.720	3.870	1.492	1.026	0.599	1.000	0.867	0.955	851	Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	MOG	242	0	436	62	0.124497991967871	TRUE	NA
ENSG00000151914.20	.	BCM	GRCh38.p13	chr6	56607633	56607633	+	A	A	C	Missense_Mutation	SNP	ENST00000361203.7	exon36	c.T6362G	p.V2121G	exonic	ENSG00000151914.20	.	nonsynonymous SNV	ENSG00000151914.20:ENST00000361203.7:exon36:c.T6362G:p.V2121G	6p12.1	C3N-02971	.	.	.	.	.	.	.	.	.	1.17	D	T	B	B	N	.	.	T	N	0.152	T	T	T	0.299	.	0.926	.	.	T	T	T	T	T	0.609	7.595	0.928	N	N	-0.731	0.761	-0.729	0.858	0.966	0.707	0.602	0.651	0.714	.	5.190	2.790	-0.215	0.232	0.756	0.000	0.002	0.107	252	.	.	.	.	DST	236	0	374	57	0.132250580046404	TRUE	NA
ENSG00000112706.12	.	BCM	GRCh38.p13	chr6	76041980	76041980	+	C	C	T	Missense_Mutation	SNP	ENST00000369950.8	exon2	c.G214A	p.A72T	exonic	ENSG00000112706.12	.	nonsynonymous SNV	ENSG00000112706.12:ENST00000369950.8:exon2:c.G214A:p.A72T	6q14.1	C3N-02971	8.244e-06	0	0	0	0	0	0.0011	0	rs769499134	0.20	T	T	B	B	N	N	L	T	N	0.192	T	T	T	0.156	0.300	0.537	0.013	T	T	T	T	T	T	0.179	2.892	0.916	N	N	-0.873	0.555	-0.839	0.703	0.000	0.487	0.574	0.574	0.564	.	6.070	-2.600	-1.138	-0.832	-0.275	0.000	0.984	0.986	378	.	.	.	ID=COSV64059410;OCCURENCE=2(large_intestine),1(haematopoietic_and_lymphoid_tissue)	IMPG1	496	0	729	47	0.0605670103092784	TRUE	TRUE
ENSG00000146282.18	.	BCM	GRCh38.p13	chr6	87541994	87541994	+	C	C	A	Missense_Mutation	SNP	ENST00000369536.10	exon8	c.G536T	p.G179V	exonic	ENSG00000146282.18	.	nonsynonymous SNV	ENSG00000146282.18:ENST00000369536.10:exon8:c.G536T:p.G179V	6q15	C3N-02971	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.967	D	D	D	0.690	0.878	0.971	0.596	T	T	D	D	D	D	5.055	33	0.998	D	D	1.050	15.572	0.954	16.289	1.000	0.732	0.725	0.744	0.728	.	5.850	5.850	5.814	1.023	0.599	1.000	0.978	0.871	799	Arginyl-tRNA_synthetase,_catalytic_core_domain	.	.	.	RARS2	307	0	505	75	0.129310344827586	TRUE	TRUE
ENSG00000026297.16	.	BCM	GRCh38.p13	chr6	166956127	166956127	+	A	A	C	Missense_Mutation	SNP	ENST00000508775.6	exon1	c.T56G	p.L19R	exonic	ENSG00000026297.16	.	nonsynonymous SNV	ENSG00000026297.16:ENST00000508775.6:exon1:c.T56G:p.L19R	6q27	C3N-02971	.	.	.	.	.	.	.	.	.	1.20	T	D	B	B	N	N	N	T	N	0.384	T	T	T	0.328	0.779	0.337	0.333	T	T	T	T	T	T	0.669	8.165	0.662	N	N	-1.192	0.232	-1.253	0.242	1.000	0.789	0.522	0.768	0.604	.	2.150	-0.086	-0.640	-0.394	-0.227	0.000	0.000	0.001	994	.	.	.	.	RNASET2	374	0	633	78	0.109704641350211	TRUE	TRUE
ENSG00000001629.10	.	BCM	GRCh38.p13	chr7	92398462	92398462	+	A	A	C	Missense_Mutation	SNP	ENST00000265742.8	exon20	c.A2783C	p.E928A	exonic	ENSG00000001629.10	.	nonsynonymous SNV	ENSG00000001629.10:ENST00000265742.8:exon20:c.A2783C:p.E928A	7q21.2	C3N-02971	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.095	T	T	T	0.064	0.071	0.284	0.073	T	T	T	T	T	T	1.728	17.220	0.969	D	N	-0.445	1.287	-0.266	1.636	0.212	0.732	0.725	0.744	0.714	.	5.610	1.530	1.804	1.312	0.756	0.982	1.000	0.996	586	.	.	.	.	ANKIB1	229	0	393	227	0.366129032258065	TRUE	TRUE
ENSG00000061337.15	.	BCM	GRCh38.p13	chr8	20249808	20249808	+	G	G	A	Missense_Mutation	SNP	ENST00000381569.5	exon4	c.C1705T	p.R569C	exonic	ENSG00000061337.15	.	nonsynonymous SNV	ENSG00000061337.15:ENST00000381569.5:exon4:c.C1705T:p.R569C	8p21.3	C3N-02971	4.12e-05	0.0002	8.639e-05	0	0	2.998e-05	0	0	rs376917114	0.20	T	T	P	B	N	N	L	T	N	0.422	T	T	T	0.083	.	0.271	1.107	T	T	T	T	T	T	2.299	21.600	0.995	N	N	-0.228	1.799	-0.201	1.784	1.000	0.701	0.574	0.717	0.639	.	5.280	4.320	1.805	1.166	0.663	0.008	0.415	0.353	935	.	.	.	ID=COSV99742849;OCCURENCE=1(upper_aerodigestive_tract)	LZTS1	264	0	407	86	0.174442190669371	TRUE	NA
ENSG00000079102.16	.	BCM	GRCh38.p13	chr8	91960492	91960492	+	G	G	A	Missense_Mutation	SNP	ENST00000613302.4	exon14	c.C1565T	p.A522V	exonic	ENSG00000079102.16	.	nonsynonymous SNV	ENSG00000079102.16:ENST00000613302.4:exon14:c.C1565T:p.A522V	8q21.3	C3N-02971	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.969	T	T	D	0.549	0.696	0.524	1.688	D	D	D	D	D	D	4.261	29.200	0.999	D	D	0.972	13.069	0.955	16.345	1.000	0.707	0.574	0.725	0.636	.	5.860	5.860	10.003	1.176	0.676	1.000	0.725	0.958	542	Zinc_finger,_MYND-type	.	.	ID=COSV56143042;OCCURENCE=1(cervix),1(stomach),1(endometrium)	RUNX1T1	213	0	338	35	0.0938337801608579	TRUE	TRUE
ENSG00000023318.8	.	BCM	GRCh38.p13	chr9	100057850	100057850	+	T	T	C	Missense_Mutation	SNP	ENST00000262455.7	exon3	c.A140G	p.D47G	exonic	ENSG00000023318.8	.	nonsynonymous SNV	ENSG00000023318.8:ENST00000262455.7:exon3:c.A140G:p.D47G	9q31.1	C3N-02971	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	N	T	D	0.245	T	T	T	0.074	0.503	0.168	0.723	T	T	T	T	D	T	2.940	23.300	0.989	D	N	-0.053	2.329	0.169	3.035	1.000	0.732	0.658	0.710	0.728	.	5.620	5.620	5.292	1.134	0.661	1.000	1.000	1.000	515	Thioredoxin_domain	.	.	.	ERP44	138	0	221	36	0.140077821011673	TRUE	TRUE
ENSG00000187714.7	.	BCM	GRCh38.p13	chr10	49611137	49611137	+	A	A	G	Missense_Mutation	SNP	ENST00000374115.5	exon1	c.A397G	p.I133V	exonic	ENSG00000187714.7	.	nonsynonymous SNV	ENSG00000187714.7:ENST00000374115.5:exon1:c.A397G:p.I133V	10q11.23	C3N-02971	.	.	.	.	.	.	.	.	.	6.20	D	T	P	P	U	D	M	T	N	0.446	T	T	T	0.280	0.463	0.677	.	T	T	T	T	D	T	3.704	25.400	0.997	D	D	0.626	6.194	0.627	6.572	1.000	0.598	0.563	0.607	0.639	.	4.940	4.940	7.203	1.312	0.756	1.000	0.997	0.988	607	Major_facilitator_superfamily_domain	.	.	.	SLC18A3	392	0	651	43	0.0619596541786743	TRUE	TRUE
ENSG00000170959.14	.	BCM	GRCh38.p13	chr11	30904998	30904998	+	C	C	T	Missense_Mutation	SNP	ENST00000597505.5	exon29	c.G4271A	p.R1424H	exonic	ENSG00000170959.14	.	nonsynonymous SNV	ENSG00000170959.14:ENST00000597505.5:exon29:c.G4271A:p.R1424H	11p14.1	C3N-02971	0.0001	0	0.0003	0	0	0.0002	0	6.058e-05	rs754104310	2.14	.	T	.	.	N	N	.	D	.	0.242	T	D	T	0.316	.	0.293	.	T	.	T	T	T	T	0.636	7.859	0.912	N	N	-1.085	0.320	-1.064	0.414	0.000	0.554	0.574	0.618	0.564	.	5.300	-3.570	-0.756	-1.333	-1.742	0.227	0.799	0.814	452	Doublecortin_domain	.	.	ID=COSV58004437;OCCURENCE=1(pancreas)	DCDC1	221	0	349	51	0.1275	TRUE	TRUE
ENSG00000165323.15	.	BCM	GRCh38.p13	chr11	92883354	92883354	+	G	G	A	Missense_Mutation	SNP	ENST00000409404.6	exon23	c.G12898A	p.D4300N	exonic	ENSG00000165323.15	.	nonsynonymous SNV	ENSG00000165323.15:ENST00000409404.6:exon23:c.G12898A:p.D4300N	11q14.3	C3N-02971	.	.	.	.	.	.	.	.	.	14.18	D	D	D	P	.	D	M	D	D	0.726	D	D	D	0.582	0.517	0.760	.	T	T	D	T	D	.	4.287	29.500	0.999	D	D	0.845	9.724	0.836	11.263	1.000	0.657	0.590	0.673	0.613	.	5.640	5.640	8.042	1.176	0.676	1.000	1.000	0.989	701	.	.	.	ID=COSV53101263;OCCURENCE=1(lung)	FAT3	62	0	97	11	0.101851851851852	TRUE	TRUE
ENSG00000110811.20	.	BCM	GRCh38.p13	chr12	6828526	6828526	+	C	C	T	Missense_Mutation	SNP	ENST00000290510.10	exon1	c.C86T	p.S29F	exonic	ENSG00000110811.20	.	nonsynonymous SNV	ENSG00000110811.20:ENST00000290510.10:exon1:c.C86T:p.S29F	12p13.31	C3N-02971	.	.	.	.	.	.	.	.	.	3.15	.	D	B	B	U	N	.	.	.	0.122	T	T	D	0.030	0.251	0.092	.	.	T	T	T	D	T	1.782	17.600	0.989	N	N	-0.544	1.091	-0.618	1.019	1.000	0.496	0.492	0.520	0.492	.	3.530	2.640	1.330	0.081	-0.314	0.005	0.942	0.608	549	.	.	.	.	P3H3	77	0	154	9	0.0552147239263804	TRUE	TRUE
ENSG00000134538.3	.	BCM	GRCh38.p13	chr12	21178697	21178697	+	A	A	T	Missense_Mutation	SNP	ENST00000256958.3	exon6	c.A603T	p.K201N	exonic	ENSG00000134538.3	.	nonsynonymous SNV	ENSG00000134538.3:ENST00000256958.3:exon6:c.A603T:p.K201N	12p12.1	C3N-02971	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	M	T	D	0.138	T	T	T	0.094	0.502	0.300	0.015	T	T	T	T	D	T	1.553	16.070	0.987	N	N	-0.456	1.265	-0.542	1.135	0.000	0.487	0.574	0.574	0.564	.	3.560	3.560	0.047	0.146	-0.228	0.000	0.924	0.551	917	Major_facilitator_superfamily_domain	.	.	.	SLCO1B1	213	0	308	21	0.0638297872340425	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-02971	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	276	0	443	60	0.119284294234592	TRUE	TRUE
ENSG00000111249.14	.	BCM	GRCh38.p13	chr12	111348184	111348184	+	C	C	A	Missense_Mutation	SNP	ENST00000261726.11	exon22	c.C4320A	p.D1440E	exonic	ENSG00000111249.14	.	nonsynonymous SNV	ENSG00000111249.14:ENST00000261726.11:exon22:c.C4320A:p.D1440E	12q24.12	C3N-02971	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.026	T	T	T	0.036	0.155	0.134	0.050	T	T	T	T	T	T	1.578	16.230	0.612	N	N	-1.076	0.328	-1.022	0.463	0.000	0.615	0.588	0.659	0.542	.	5.580	2.570	0.764	0.077	-0.182	0.314	0.014	0.031	588	.	.	.	.	CUX2	237	0	407	22	0.0512820512820513	TRUE	NA
ENSG00000133983.16	.	BCM	GRCh38.p13	chr14	70359542	70359542	+	G	G	T	Missense_Mutation	SNP	ENST00000389912.7	exon1	c.C46A	p.L16I	exonic	ENSG00000133983.16	.	nonsynonymous SNV	ENSG00000133983.16:ENST00000389912.7:exon1:c.C46A:p.L16I	14q24.2	C3N-02971	.	.	.	.	.	.	.	.	.	0.18	T	T	P	B	U	N	L	.	N	0.260	T	T	T	0.133	0.274	0.200	0.195	.	T	T	T	T	T	1.783	17.610	0.980	N	N	-0.349	1.498	-0.300	1.564	1.000	0.442	0.522	0.522	0.562	.	5.320	3.500	0.963	0.227	-0.103	0.960	0.752	0.720	861	.	.	.	.	COX16	163	0	346	33	0.0870712401055409	TRUE	TRUE
ENSG00000182256.13	.	BCM	GRCh38.p13	chr15	27520104	27520104	+	C	C	T	Missense_Mutation	SNP	ENST00000615808.5	exon7	c.C845T	p.T282M	exonic	ENSG00000182256.13	.	nonsynonymous SNV	ENSG00000182256.13:ENST00000615808.5:exon7:c.C845T:p.T282M	15q12	C3N-02971	.	.	.	.	.	.	.	.	.	15.20	D	D	D	P	D	D	M	D	N	0.528	D	D	D	0.516	0.622	0.755	1.543	T	T	D	T	D	D	3.301	24.100	0.999	D	D	0.588	5.799	0.607	6.318	0.895	0.487	0.574	0.574	0.564	.	5.390	5.390	2.102	1.023	0.595	0.917	0.996	0.977	988	Neurotransmitter-gated_ion-channel_transmembrane_domain	.	.	ID=COSV61529562;OCCURENCE=1(large_intestine)	GABRG3	203	0	340	26	0.0710382513661202	TRUE	TRUE
ENSG00000174485.15	.	BCM	GRCh38.p13	chr15	65669822	65669822	+	C	C	T	Missense_Mutation	SNP	ENST00000431932.6	exon26	c.G4612A	p.D1538N	exonic	ENSG00000174485.15	.	nonsynonymous SNV	ENSG00000174485.15:ENST00000431932.6:exon26:c.G4612A:p.D1538N	15q22.31	C3N-02971	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.104	T	T	T	0.057	0.175	0.467	0.088	T	T	T	T	T	T	1.887	18.390	0.987	D	N	-0.164	1.978	0.012	2.402	0.999	0.732	0.744	0.659	0.674	.	5.640	5.640	0.221	1.026	0.599	0.828	1.000	0.947	716	.	.	.	.	DENND4A	184	0	282	18	0.06	TRUE	TRUE
ENSG00000007384.15	.	BCM	GRCh38.p13	chr16	60496	60496	+	G	G	C	Missense_Mutation	SNP	ENST00000262316.10	exon12	c.C1601G	p.A534G	exonic	ENSG00000007384.15	.	nonsynonymous SNV	ENSG00000007384.15:ENST00000262316.10:exon12:c.C1601G:p.A534G	16p13.3	C3N-02971	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.187	T	T	T	0.110	0.234	0.286	0.424	T	T	T	T	D	D	2.354	21.900	0.709	D	D	-0.340	1.518	-0.084	2.094	1.000	0.672	0.694	0.702	0.711	.	5.380	5.380	5.022	1.172	0.672	1.000	0.969	0.896	946	.	.	.	.	RHBDF1	182	0	325	32	0.0896358543417367	TRUE	TRUE
ENSG00000205832.7	.	BCM	GRCh38.p13	chr16	4576312	4576312	+	C	C	T	Missense_Mutation	SNP	ENST00000444310.4	exon5	c.C1832T	p.T611M	exonic	ENSG00000205832.7	.	nonsynonymous SNV	ENSG00000205832.7:ENST00000444310.4:exon5:c.C1832T:p.T611M	16p13.3	C3N-02971	5.636e-05	0	0	0	0	0.0001	0	0	rs759379003	0.17	T	T	B	B	.	N	N	.	N	0.052	T	T	T	0.057	0.341	0.030	.	.	T	T	T	T	T	-1.523	0.001	0.653	N	N	-1.812	0.022	-1.906	0.021	0.960	0.615	0.574	0.659	0.613	.	3.710	-7.430	-3.467	-0.215	-0.254	0.000	0.000	0.001	520	.	.	.	.	C16orf96	262	0	432	37	0.0788912579957356	TRUE	NA
ENSG00000171241.9	.	BCM	GRCh38.p13	chr16	46621350	46621350	+	C	C	A	Missense_Mutation	SNP	ENST00000303383.8	exon1	c.G10T	p.G4W	exonic	ENSG00000171241.9	.	nonsynonymous SNV	ENSG00000171241.9:ENST00000303383.8:exon1:c.G10T:p.G4W	16q11.2	C3N-02971	8.876e-06	0	0	0	0	1.63e-05	0	0	rs759988033	3.20	T	D	D	D	N	N	L	T	N	0.199	T	T	T	0.065	0.240	0.173	0.291	T	T	T	T	T	T	1.668	16.810	0.965	N	N	-0.312	1.586	-0.506	1.192	1.000	0.267	0.093	0.474	0.373	.	3.830	2.870	-0.025	0.031	-0.245	0.000	0.052	0.012	367	.	.	.	.	SHCBP1	209	0	344	86	0.2	TRUE	NA
ENSG00000103335.22	.	BCM	GRCh38.p13	chr16	88716018	88716018	+	A	A	G	Missense_Mutation	SNP	ENST00000301015.14	exon50	c.T7231C	p.C2411R	exonic	ENSG00000103335.22	.	nonsynonymous SNV	ENSG00000103335.22:ENST00000301015.14:exon50:c.T7231C:p.C2411R	16q24.3	C3N-02971	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	N	D	L	T	D	0.642	T	T	D	0.557	0.607	0.210	.	T	T	T	T	D	T	2.937	23.300	0.986	D	.	-0.035	2.389	-0.020	2.291	1.000	0.672	0.702	0.723	0.711	.	4.400	4.400	3.463	1.168	0.686	1.000	0.450	0.060	895	Piezo_non-specific_cation_channel,_R-Ras-binding_domain	.	.	.	PIEZO1	177	0	371	23	0.0583756345177665	TRUE	TRUE
ENSG00000108405.4	.	BCM	GRCh38.p13	chr17	3903629	3903629	+	G	G	A	Missense_Mutation	SNP	ENST00000225538.4	exon6	c.C527T	p.P176L	exonic	ENSG00000108405.4	.	nonsynonymous SNV	ENSG00000108405.4:ENST00000225538.4:exon6:c.C527T:p.P176L	17p13.2	C3N-02971	.	.	.	.	.	.	.	.	.	10.20	D	D	P	P	D	D	M	T	D	0.613	T	T	T	0.219	0.653	0.531	1.058	T	T	T	T	D	D	4.052	27.400	0.999	D	D	0.590	5.825	0.548	5.631	1.000	0.615	0.634	0.535	0.613	.	5.370	4.400	5.732	1.176	0.676	1.000	0.997	0.979	317	.	.	.	.	P2RX1	430	0	560	114	0.169139465875371	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674250	7674250	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.G713A	p.C238Y	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.G713A:p.C238Y	17p13.1	C3N-02971	1.648e-05	0	0	0	0	2.997e-05	0	0	rs730882005	20.20	D	D	D	D	D	D	M	D	D	0.978	D	D	D	0.957	0.989	0.993	0.492	D	D	D	D	D	D	4.116	27.900	0.997	D	D	0.869	10.286	0.765	9.165	1.000	0.722	0.702	0.725	0.735	.	4.090	4.090	7.829	1.021	0.596	1.000	1.000	1.000	433	p53,_DNA-binding_domain	.	.	ID=COSV52661646;OCCURENCE=1(salivary_gland),25(breast),1(liver),16(oesophagus),19(large_intestine),10(central_nervous_system),3(biliary_tract),13(ovary),1(bone),5(stomach),20(haematopoietic_and_lymphoid_tissue),3(urinary_tract),9(soft_tissue),14(pancreas),2(skin),3(prostate),5(lung),2(thyroid),4(upper_aerodigestive_tract),5(endometrium)	TP53	352	0	486	179	0.269172932330827	TRUE	TRUE
ENSG00000133026.13	.	BCM	GRCh38.p13	chr17	8535930	8535930	+	G	G	A	Missense_Mutation	SNP	ENST00000269243.8	exon14	c.C1577T	p.A526V	exonic	ENSG00000133026.13	.	nonsynonymous SNV	ENSG00000133026.13:ENST00000269243.8:exon14:c.C1577T:p.A526V	17p13.1	C3N-02971	1.655e-05	0	0	0	0	3.006e-05	0	0	rs752480302	8.20	T	T	B	B	D	D	N	D	N	0.587	T	T	D	0.421	0.451	0.726	1.455	D	T	T	T	T	D	3.269	24.000	0.997	D	D	0.230	3.436	0.394	4.313	1.000	0.707	0.670	0.725	0.714	.	5.420	5.420	9.985	1.176	0.676	1.000	0.968	0.931	561	Myosin_head,_motor_domain	.	.	.	MYH10	93	0	118	53	0.309941520467836	TRUE	NA
ENSG00000172156.4	.	BCM	GRCh38.p13	chr17	34285821	34285821	+	G	G	A	Missense_Mutation	SNP	ENST00000305869.4	exon1	c.G13A	p.A5T	exonic	ENSG00000172156.4	.	nonsynonymous SNV	ENSG00000172156.4:ENST00000305869.4:exon1:c.G13A:p.A5T	17q12	C3N-02971	0.0001	0.0002	0	0.0001	0	0.0001	0	0.0004	rs56120942	0.19	T	T	B	B	N	N	.	T	N	0.059	T	T	T	0.035	.	0.329	0.009	T	T	T	T	T	T	-0.384	0.208	0.874	N	N	-1.295	0.167	-1.402	0.150	0.000	0.487	0.574	0.574	0.530	.	4.680	-4.260	-0.597	-0.481	-0.105	0.000	0.000	0.001	819	.	.	.	ID=COSV59925160;OCCURENCE=2(large_intestine)	CCL11	114	0	180	30	0.142857142857143	TRUE	TRUE
ENSG00000120071.14	.	BCM	GRCh38.p13	chr17	46171872	46171872	+	G	G	T	Missense_Mutation	SNP	ENST00000432791.6	exon2	c.C272A	p.P91H	exonic	ENSG00000120071.14	.	nonsynonymous SNV	ENSG00000120071.14:ENST00000432791.6:exon2:c.C272A:p.P91H	17q21.31	C3N-02971	.	.	.	.	.	.	.	.	.	8.17	D	D	.	.	N	D	.	T	D	0.370	T	T	T	0.165	0.261	0.202	0.126	T	T	T	T	D	D	3.810	25.900	0.995	D	D	0.590	5.826	0.671	7.250	1.000	0.722	0.702	0.699	0.714	.	5.870	5.870	8.954	1.163	0.676	1.000	0.996	1.000	169	.	.	.	.	KANSL1	612	0	975	87	0.0819209039548023	TRUE	TRUE
ENSG00000166685.12	.	BCM	GRCh38.p13	chr17	73193277	73193277	+	C	C	T	Missense_Mutation	SNP	ENST00000299886.9	exon1	c.C208T	p.R70C	exonic	ENSG00000166685.12	.	nonsynonymous SNV	ENSG00000166685.12:ENST00000299886.9:exon1:c.C208T:p.R70C	17q25.1	C3N-02971	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.481	T	T	D	0.243	0.712	0.411	2.043	D	T	T	T	D	D	4.473	32	0.990	N	N	0.468	4.799	0.408	4.414	1.000	0.442	0.522	0.522	0.562	.	3.890	3.890	2.483	0.939	0.439	1.000	0.999	0.905	584	.	.	.	.	COG1	288	0	414	84	0.168674698795181	TRUE	TRUE
ENSG00000141519.15	.	BCM	GRCh38.p13	chr17	80084945	80084945	+	A	A	G	Missense_Mutation	SNP	ENST00000397545.9	exon13	c.A2192G	p.N731S	exonic	ENSG00000141519.15	.	nonsynonymous SNV	ENSG00000141519.15:ENST00000397545.9:exon13:c.A2192G:p.N731S	17q25.3	C3N-02971	8.402e-06	0	0	0	0	1.519e-05	0	0	rs376612893	1.19	T	T	B	B	.	N	L	T	N	0.180	T	T	T	0.127	.	0.363	0.203	T	T	T	T	T	T	2.060	19.710	0.992	D	N	-0.054	2.324	0.074	2.629	0.025	0.646	0.563	0.645	0.530	.	5.060	5.060	1.694	1.232	0.665	0.984	1.000	0.985	884	.	.	.	.	CCDC40	403	0	690	49	0.0663058186738836	TRUE	NA
ENSG00000065717.15	.	BCM	GRCh38.p13	chr19	3014586	3014586	+	T	T	C	Missense_Mutation	SNP	ENST00000262953.11	exon10	c.A707G	p.N236S	exonic	ENSG00000065717.15	.	nonsynonymous SNV	ENSG00000065717.15:ENST00000262953.11:exon10:c.A707G:p.N236S	19p13.3	C3N-02971	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.649	T	T	D	0.263	0.398	0.911	0.244	T	T	T	T	D	D	3.110	23.700	0.994	D	D	0.498	5.018	0.376	4.193	0.998	0.706	0.610	0.710	0.714	.	3.860	3.860	7.116	0.206	0.664	1.000	0.815	0.087	982	.	.	.	.	TLE2	44	0	77	10	0.114942528735632	TRUE	NA
ENSG00000128011.4	.	BCM	GRCh38.p13	chr19	39314058	39314058	+	G	G	A	Missense_Mutation	SNP	ENST00000248668.4	exon1	c.C1279T	p.R427W	exonic	ENSG00000128011.4	.	nonsynonymous SNV	ENSG00000128011.4:ENST00000248668.4:exon1:c.C1279T:p.R427W	19q13.2	C3N-02971	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.341	T	T	D	0.292	0.585	0.318	.	T	T	D	T	D	D	2.998	23.400	0.999	N	D	0.113	2.938	-0.031	2.255	0.000	0.701	0.588	0.717	0.568	.	4.530	0.848	-0.406	-0.235	0.676	0.000	0.623	0.365	544	Fibronectin_type_III	.	.	ID=COSV50434815;OCCURENCE=1(cervix)	LRFN1	197	0	319	48	0.130790190735695	TRUE	TRUE
ENSG00000077312.9	.	BCM	GRCh38.p13	chr19	40762981	40762981	+	G	G	C	Missense_Mutation	SNP	ENST00000243563.8	exon4	c.G507C	p.M169I	exonic	ENSG00000077312.9	.	nonsynonymous SNV	ENSG00000077312.9:ENST00000243563.8:exon4:c.G507C:p.M169I	19q13.2	C3N-02971	.	.	.	.	.	.	.	.	.	8.20	T	T	P	P	D	D	L	T	N	0.681	T	T	D	0.129	0.231	0.659	0.997	D	T	T	T	D	D	3.240	24.000	0.996	D	D	0.638	6.334	0.687	7.517	1.000	0.707	0.702	0.702	0.714	.	5.540	5.540	8.800	1.176	0.676	1.000	0.999	0.980	494	.	.	.	.	SNRPA	183	0	248	52	0.173333333333333	TRUE	TRUE
ENSG00000160013.9	.	BCM	GRCh38.p13	chr19	46621323	46621323	+	G	G	A	Missense_Mutation	SNP	ENST00000291294.7	exon3	c.C1118T	p.T373M	exonic	ENSG00000160013.9	.	nonsynonymous SNV	ENSG00000160013.9:ENST00000291294.7:exon3:c.C1118T:p.T373M	19q13.32	C3N-02971	9.137e-06	0	0	0.0001	0	0	0	0	rs768787228	0.20	T	T	B	B	N	N	N	T	N	0.110	T	T	T	0.070	0.161	0.700	0.180	T	T	T	T	T	T	1.067	12.430	0.728	N	N	-0.948	0.462	-0.919	0.595	1.000	0.543	0.686	0.618	0.568	.	4.750	2.430	0.696	0.245	0.676	0.001	0.002	0.027	929	.	.	.	ID=COSV104394174;OCCURENCE=1(large_intestine)	PTGIR	17	0	48	4	0.0769230769230769	TRUE	NA
ENSG00000126001.16	.	BCM	GRCh38.p13	chr20	35501934	35501934	+	C	C	T	Missense_Mutation	SNP	ENST00000397527.6	exon29	c.C3988T	p.R1330W	exonic	ENSG00000126001.16	.	nonsynonymous SNV	ENSG00000126001.16:ENST00000397527.6:exon29:c.C3988T:p.R1330W	20q11.22	C3N-02971	5.81e-05	0	0.0004	0	0	3.018e-05	0	0	rs773111712	6.20	D	D	D	P	N	N	M	T	D	0.290	T	T	T	0.051	.	0.427	0.153	T	T	T	T	T	D	2.992	23.400	0.998	N	N	-0.004	2.498	-0.136	1.947	1.000	0.722	0.699	0.725	0.636	.	5.110	1.840	0.204	1.026	0.599	0.005	0.903	0.933	549	.	.	.	.	CEP250	135	0	257	22	0.0788530465949821	TRUE	NA
ENSG00000169184.6	.	BCM	GRCh38.p13	chr22	27799166	27799166	+	C	C	T	Missense_Mutation	SNP	ENST00000302326.5	exon1	c.G1378A	p.D460N	exonic	ENSG00000169184.6	.	nonsynonymous SNV	ENSG00000169184.6:ENST00000302326.5:exon1:c.G1378A:p.D460N	22q12.1	C3N-02971	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	D	D	L	T	D	0.502	T	T	D	0.307	0.338	0.937	.	D	T	T	T	D	D	4.209	28.700	0.998	D	D	0.478	4.872	0.505	5.206	1.000	0.658	0.588	0.619	0.621	.	4.920	4.920	7.359	0.939	0.442	1.000	0.997	0.991	982	.	.	.	.	MN1	90	0	150	13	0.0797546012269939	TRUE	TRUE
ENSG00000173852.14	.	BCM	GRCh38.p13	chr7	34989942	34989942	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000173852.14	ENST00000310974.8:exon7:c.546-1G>A	.	.	7p14.2	C3N-02971	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.642	34	0.995	D	.	1.028	14.817	0.866	12.363	0.995	0.078	0.097	0.079	0.093	0.976	5.270	5.270	4.089	1.021	0.596	1.000	0.956	0.767	701	.	.	.	.	DPY19L1	136	0	265	52	0.16403785488959	NA	TRUE
ENSG00000143631.11	.	BCM	GRCh38.p13	chr1	152304929	152304929	+	C	C	T	Silent	SNP	ENST00000368799.2	exon3	c.G9957A	p.P3319P	exonic	ENSG00000143631.11	.	synonymous SNV	ENSG00000143631.11:ENST00000368799.2:exon3:c.G9957A:p.P3319P	1q21.3	C3N-02971	1.647e-05	0	8.637e-05	0	0	1.498e-05	0	0	rs774241945	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64242888;OCCURENCE=1(oesophagus),1(prostate)	FLG	539	0	806	134	0.142553191489362	NA	TRUE
ENSG00000135829.17	.	BCM	GRCh38.p13	chr1	182858165	182858165	+	A	A	G	Silent	SNP	ENST00000367549.4	exon8	c.A735G	p.S245S	exonic	ENSG00000135829.17	.	synonymous SNV	ENSG00000135829.17:ENST00000367549.4:exon8:c.A735G:p.S245S	1q25.3	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DHX9	201	0	309	36	0.104347826086957	TRUE	TRUE
ENSG00000197410.14	.	BCM	GRCh38.p13	chr4	154235285	154235285	+	G	G	A	Silent	SNP	ENST00000357232.10	exon20	c.C9367T	p.L3123L	exonic	ENSG00000197410.14	.	synonymous SNV	ENSG00000197410.14:ENST00000357232.10:exon20:c.C9367T:p.L3123L	4q31.3	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DCHS2	156	0	229	20	0.0803212851405622	TRUE	TRUE
ENSG00000072682.18	.	BCM	GRCh38.p13	chr5	132193043	132193043	+	G	G	A	Silent	SNP	ENST00000401867.5	exon16	c.C1575T	p.F525F	exonic	ENSG00000072682.18	.	synonymous SNV	ENSG00000072682.18:ENST00000401867.5:exon16:c.C1575T:p.F525F	5q31.1	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P4HA2	117	0	234	19	0.075098814229249	TRUE	TRUE
ENSG00000276547.1	.	BCM	GRCh38.p13	chr5	141399783	141399783	+	C	C	T	Silent	SNP	ENST00000617380.1	exon1	c.C1656T	p.N552N	exonic	ENSG00000276547.1	.	synonymous SNV	ENSG00000276547.1:ENST00000617380.1:exon1:c.C1656T:p.N552N	5q31.3	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53956513;OCCURENCE=1(pancreas)	PCDHGB5	523	0	744	110	0.128805620608899	NA	TRUE
ENSG00000146648.18	.	BCM	GRCh38.p13	chr7	55200392	55200392	+	C	C	T	Silent	SNP	ENST00000275493.7	exon24	c.C2925T	p.P975P	exonic	ENSG00000146648.18	.	synonymous SNV	ENSG00000146648.18:ENST00000275493.7:exon24:c.C2925T:p.P975P	7p11.2	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EGFR	559	0	796	104	0.115555555555556	TRUE	TRUE
ENSG00000133878.9	.	BCM	GRCh38.p13	chr8	33593642	33593642	+	C	C	A	Silent	SNP	ENST00000256261.9	exon3	c.G327T	p.L109L	exonic	ENSG00000133878.9	.	synonymous SNV	ENSG00000133878.9:ENST00000256261.9:exon3:c.G327T:p.L109L	8p12	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DUSP26	479	1	749	61	0.0753086419753086	TRUE	TRUE
ENSG00000169583.13	.	BCM	GRCh38.p13	chr9	136995480	136995480	+	C	C	T	Silent	SNP	ENST00000494426.2	exon3	c.G231A	p.Q77Q	exonic	ENSG00000169583.13	.	synonymous SNV	ENSG00000169583.13:ENST00000494426.2:exon3:c.G231A:p.Q77Q	9q34.3	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLIC3	147	0	246	31	0.111913357400722	TRUE	TRUE
ENSG00000078403.17	.	BCM	GRCh38.p13	chr10	21727926	21727926	+	A	A	C	Silent	SNP	ENST00000307729.12	exon16	c.A2061C	p.P687P	exonic	ENSG00000078403.17	.	synonymous SNV	ENSG00000078403.17:ENST00000307729.12:exon16:c.A2061C:p.P687P	10p12.31	C3N-02971	8.637e-06	0	0	0	0.0002	0	0	0	rs745498825	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MLLT10	220	0	306	28	0.0838323353293413	TRUE	NA
ENSG00000110799.13	.	BCM	GRCh38.p13	chr12	6056906	6056906	+	G	G	A	Silent	SNP	ENST00000261405.9	exon15	c.C1896T	p.A632A	exonic	ENSG00000110799.13	.	synonymous SNV	ENSG00000110799.13:ENST00000261405.9:exon15:c.C1896T:p.A632A	12p13.31	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VWF	182	0	335	59	0.149746192893401	TRUE	TRUE
ENSG00000089250.19	.	BCM	GRCh38.p13	chr12	117280767	117280767	+	G	G	A	Silent	SNP	ENST00000317775.11	exon8	c.C1482T	p.D494D	exonic	ENSG00000089250.19	.	synonymous SNV	ENSG00000089250.19:ENST00000317775.11:exon8:c.C1482T:p.D494D	12q24.22	C3N-02971	0.0005	0.0001	8.646e-05	0.0052	0	9.013e-05	0	0.0001	rs181652902	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57607214;OCCURENCE=2(central_nervous_system),1(lung)	NOS1	226	0	442	30	0.0635593220338983	TRUE	TRUE
ENSG00000166206.15	.	BCM	GRCh38.p13	chr15	26560956	26560956	+	G	G	A	Silent	SNP	ENST00000311550.10	exon8	c.C1056T	p.D352D	exonic	ENSG00000166206.15	.	synonymous SNV	ENSG00000166206.15:ENST00000311550.10:exon8:c.C1056T:p.D352D	15q12	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GABRB3	317	0	512	42	0.075812274368231	TRUE	TRUE
ENSG00000215041.10	.	BCM	GRCh38.p13	chr17	7327558	7327558	+	G	G	A	Silent	SNP	ENST00000399464.7	exon2	c.C609T	p.T203T	exonic	ENSG00000215041.10	.	synonymous SNV	ENSG00000215041.10:ENST00000399464.7:exon2:c.C609T:p.T203T	17p13.1	C3N-02971	8.511e-06	0.0001	0	0	0	0	0	0	rs372129260	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEURL4	72	0	180	12	0.0625	TRUE	NA
ENSG00000186868.15	.	BCM	GRCh38.p13	chr17	45983353	45983353	+	C	C	T	Silent	SNP	ENST00000262410.9	exon6	c.C549T	p.H183H	exonic	ENSG00000186868.15	.	synonymous SNV	ENSG00000186868.15:ENST00000262410.9:exon6:c.C549T:p.H183H	17q21.31	C3N-02971	0.0001	0	0	0	0.0033	0	0.0018	0	rs761089103	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAPT	91	0	181	13	0.0670103092783505	TRUE	NA
ENSG00000142235.11	.	BCM	GRCh38.p13	chr19	48498387	48498387	+	G	G	A	Silent	SNP	ENST00000600059.5	exon11	c.C2682T	p.P894P	exonic	ENSG00000142235.11	.	synonymous SNV	ENSG00000142235.11:ENST00000600059.5:exon11:c.C2682T:p.P894P	19q13.33	C3N-02971	4.923e-05	0	0.0001	0	0	0	0	0.0003	rs747292842	1.3	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	0.719	8.632	0.698	N	N	.	.	.	.	1.000	0.696	0.634	0.723	0.563	.	3.570	2.400	-0.049	1.074	0.676	0.000	1.000	0.968	958	.	.	.	ID=COSV99539893;OCCURENCE=1(breast),1(endometrium)	LMTK3	359	0	546	99	0.153488372093023	TRUE	NA
ENSG00000268089.3	.	BCM	GRCh38.p13	chrX	152649749	152649749	+	C	C	T	Silent	SNP	ENST00000598523.3	exon6	c.C618T	p.Y206Y	exonic	ENSG00000268089.3	.	synonymous SNV	ENSG00000268089.3:ENST00000598523.3:exon6:c.C618T:p.Y206Y	Xq28	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GABRQ	200	0	265	51	0.161392405063291	TRUE	TRUE
ENSG00000109689.17	.	BCM	GRCh38.p13	chr4	27021017	27021017	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000109689.17	.	.	.	4p15.2	C3N-02971	.	.	.	.	.	.	.	.	rs750475852	2.15	T	D	.	.	.	N	.	T	N	.	T	T	D	0.153	0.124	0.067	.	.	T	T	T	T	T	-0.611	0.069	0.421	N	N	-2.023	0.008	-2.047	0.011	0.414	0.707	0.725	0.602	0.568	.	3.220	-4.380	-0.591	-3.181	-1.162	0.000	0.000	0.022	674	.	.	.	.	STIM2	113	0	204	15	0.0684931506849315	TRUE	NA
ENSG00000054690.14	.	BCM	GRCh38.p13	chr14	67582242	67582242	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000054690.14	.	.	.	14q24.1	C3N-02971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEKHH1	201	0	372	34	0.083743842364532	TRUE	TRUE
ENSG00000142733.17	.	BCM	GRCh38.p13	chr1	27357084	27357084	+	G	G	-	Frame_Shift_Del	DEL	ENST00000357582.3	exon24	c.3289delC	p.R1097Vfs*23	exonic	ENSG00000142733.17	.	frameshift deletion	ENSG00000142733.17:ENST00000357582.3:exon24:c.3289delC:p.R1097Vfs*23	1p36.11	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP3K6	329	0	394	57	0.126385809312639	TRUE	NA
ENSG00000117013.17	.	BCM	GRCh38.p13	chr1	40838461	40838461	+	G	G	T	Missense_Mutation	SNP	ENST00000347132.10	exon14	c.G2026T	p.D676Y	exonic	ENSG00000117013.17	.	nonsynonymous SNV	ENSG00000117013.17:ENST00000347132.10:exon14:c.G2026T:p.D676Y	1p34.2	C3N-02573	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	D	D	0.586	T	T	D	0.836	0.425	0.923	2.309	T	D	D	D	D	D	4.188	28.500	0.994	D	D	0.299	3.776	0.398	4.345	1.000	0.718	0.588	0.571	0.542	.	4.910	4.910	6.783	1.176	0.676	1.000	1.000	0.999	664	.	.	.	.	KCNQ4	427	0	502	60	0.106761565836299	TRUE	TRUE
ENSG00000143537.13	.	BCM	GRCh38.p13	chr1	155058014	155058014	+	A	A	G	Missense_Mutation	SNP	ENST00000356955.6	exon14	c.A1580G	p.Y527C	exonic	ENSG00000143537.13	.	nonsynonymous SNV	ENSG00000143537.13:ENST00000356955.6:exon14:c.A1580G:p.Y527C	1q21.3	C3N-02573	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	N	D	M	T	D	0.774	T	T	T	0.249	.	0.680	0.928	T	T	T	T	D	D	3.938	26.600	0.998	D	D	0.692	7.010	0.642	6.798	1.000	0.744	0.695	0.630	0.714	.	5.100	5.100	3.067	1.298	0.740	0.146	0.992	0.991	213	ADAM,_cysteine-rich	.	.	.	ADAM15	531	0	756	95	0.111633372502938	TRUE	NA
ENSG00000116962.15	.	BCM	GRCh38.p13	chr1	235993765	235993765	+	C	C	T	Missense_Mutation	SNP	ENST00000264187.7	exon13	c.G2635A	p.D879N	exonic	ENSG00000116962.15	.	nonsynonymous SNV	ENSG00000116962.15:ENST00000264187.7:exon13:c.G2635A:p.D879N	1q42.3	C3N-02573	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.690	D	D	D	0.464	0.624	0.868	0.795	T	T	T	T	D	D	3.450	24.600	0.999	D	D	0.655	6.538	0.598	6.199	1.000	0.706	0.710	0.710	0.714	.	5.690	5.690	5.966	1.015	0.599	1.000	0.756	0.226	424	Thyroglobulin_type-1	.	.	ID=COSV51614984;OCCURENCE=3(oesophagus),1(haematopoietic_and_lymphoid_tissue)	NID1	407	0	481	60	0.11090573012939	TRUE	TRUE
ENSG00000162849.16	.	BCM	GRCh38.p13	chr1	245367285	245367285	+	C	C	T	Missense_Mutation	SNP	ENST00000407071.7	exon3	c.C917T	p.S306L	exonic	ENSG00000162849.16	.	nonsynonymous SNV	ENSG00000162849.16:ENST00000407071.7:exon3:c.C917T:p.S306L	1q44	C3N-02573	.	.	.	.	.	.	.	.	rs1034978766	12.20	D	D	P	B	N	D	M	T	D	0.553	T	D	D	0.438	0.411	0.513	0.269	T	T	D	T	D	D	2.917	23.200	0.998	D	D	0.449	4.664	0.522	5.362	1.000	0.554	0.588	0.624	0.564	.	5.750	5.750	5.301	1.026	0.599	0.996	0.963	0.939	980	.	.	.	ID=COSV68572526;OCCURENCE=1(breast),1(large_intestine),1(pleura)	KIF26B	321	1	377	45	0.106635071090047	TRUE	TRUE
ENSG00000138039.15	.	BCM	GRCh38.p13	chr2	48687718	48687718	+	C	C	G	Missense_Mutation	SNP	ENST00000294954.12	exon11	c.G2079C	p.K693N	exonic	ENSG00000138039.15	.	nonsynonymous SNV	ENSG00000138039.15:ENST00000294954.12:exon11:c.G2079C:p.K693N	2p16.3	C3N-02573	8.24e-06	0	0	0.0001	0	0	0	0	rs759440300	5.20	D	D	P	B	N	D	L	T	N	0.182	T	T	D	0.204	0.192	0.877	0.100	T	T	T	T	T	T	1.652	16.710	0.994	D	N	-0.195	1.890	-0.199	1.788	0.018	0.487	0.574	0.547	0.613	.	4.700	4.700	0.352	0.088	0.549	0.140	0.502	0.815	527	.	.	.	.	LHCGR	185	0	244	21	0.0792452830188679	TRUE	NA
ENSG00000113916.18	.	BCM	GRCh38.p13	chr3	187729233	187729233	+	T	T	C	Missense_Mutation	SNP	ENST00000406870.7	exon5	c.A1172G	p.K391R	exonic	ENSG00000113916.18	.	nonsynonymous SNV	ENSG00000113916.18:ENST00000406870.7:exon5:c.A1172G:p.K391R	3q27.3	C3N-02573	8.24e-06	0	0	0	0	0	0	6.056e-05	rs769861975	8.20	D	T	D	D	D	D	L	T	N	0.593	T	T	T	0.188	0.351	0.460	0.645	T	T	T	T	D	T	3.416	24.500	0.999	D	D	0.261	3.586	0.370	4.154	1.000	0.563	0.590	0.609	0.636	.	5.610	5.610	5.902	1.138	0.665	1.000	1.000	0.998	939	.	.	.	.	BCL6	150	0	181	24	0.117073170731707	TRUE	NA
ENSG00000183090.5	.	BCM	GRCh38.p13	chr4	143699117	143699117	+	C	C	T	Missense_Mutation	SNP	ENST00000329798.5	exon1	c.G1559A	p.R520Q	exonic	ENSG00000183090.5	.	nonsynonymous SNV	ENSG00000183090.5:ENST00000329798.5:exon1:c.G1559A:p.R520Q	4q31.21	C3N-02573	5.049e-05	0	0.0033	0	0	0	0	0	rs532088660	1.18	T	T	.	.	N	N	L	T	D	0.106	T	T	T	0.085	0.533	0.048	.	T	T	T	T	T	T	0.138	2.453	0.968	N	N	-0.970	0.437	-1.147	0.330	0.999	0.447	0.563	0.563	0.530	.	4.160	-3.000	0.626	-0.299	-0.187	0.009	0.067	0.154	811	.	.	.	.	FREM3	369	0	397	50	0.111856823266219	TRUE	NA
ENSG00000155511.18	.	BCM	GRCh38.p13	chr5	153811115	153811115	+	G	G	A	Missense_Mutation	SNP	ENST00000285900.10	exon16	c.G2611A	p.G871S	exonic	ENSG00000155511.18	.	nonsynonymous SNV	ENSG00000155511.18:ENST00000285900.10:exon16:c.G2611A:p.G871S	5q33.2	C3N-02573	1.649e-05	0	0	0.0001	0	1.5e-05	0	0	rs139089198	6.20	T	T	D	D	D	D	N	T	N	0.303	T	T	T	0.181	.	0.804	1.233	T	T	T	T	T	D	2.032	19.500	0.401	D	N	-0.419	1.341	-0.200	1.786	0.971	0.487	0.574	0.574	0.564	.	3.780	3.780	4.720	1.174	0.676	1.000	0.995	0.994	792	.	.	.	ID=COSV53613412;OCCURENCE=1(prostate)	GRIA1	538	1	593	78	0.116244411326379	TRUE	TRUE
ENSG00000168269.10	.	BCM	GRCh38.p13	chr5	170108181	170108181	+	G	G	A	Missense_Mutation	SNP	ENST00000306268.8	exon2	c.G707A	p.S236N	exonic	ENSG00000168269.10	.	nonsynonymous SNV	ENSG00000168269.10:ENST00000306268.8:exon2:c.G707A:p.S236N	5q35.1	C3N-02573	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	D	N	0.018	T	T	D	0.235	0.184	0.734	0.160	T	T	T	T	T	T	-0.661	0.053	0.594	N	N	-1.469	0.091	-1.413	0.145	0.991	0.497	0.590	0.563	0.613	.	4.910	-3.620	0.485	-0.086	-0.116	0.805	0.698	0.260	946	.	.	.	.	FOXI1	618	0	695	94	0.119138149556401	TRUE	NA
ENSG00000078053.17	.	BCM	GRCh38.p13	chr7	38476954	38476954	+	G	G	A	Missense_Mutation	SNP	ENST00000356264.7	exon6	c.C412T	p.R138C	exonic	ENSG00000078053.17	.	nonsynonymous SNV	ENSG00000078053.17:ENST00000356264.7:exon6:c.C412T:p.R138C	7p14.1	C3N-02573	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.840	D	D	D	0.764	0.648	0.883	0.881	D	D	D	D	D	D	4.234	29.000	0.999	D	N	0.622	6.154	0.530	5.443	0.037	0.644	0.624	0.653	0.632	.	5.520	3.380	1.637	1.176	0.618	1.000	0.998	0.997	786	BAR_domain	.	.	ID=COSV57737817;OCCURENCE=3(oesophagus),1(large_intestine),1(endometrium)	AMPH	213	0	265	34	0.11371237458194	TRUE	TRUE
ENSG00000146834.14	.	BCM	GRCh38.p13	chr7	100431504	100431504	+	C	C	T	Missense_Mutation	SNP	ENST00000310512.4	exon1	c.C1486T	p.R496C	exonic	ENSG00000146834.14	.	nonsynonymous SNV	ENSG00000146834.14:ENST00000310512.4:exon1:c.C1486T:p.R496C	7q22.1	C3N-02573	.	.	.	.	.	.	.	.	.	8.19	D	D	B	B	N	D	M	.	N	0.441	T	T	T	0.171	0.489	0.328	2.259	T	T	D	T	D	D	2.713	22.900	0.999	D	N	-0.409	1.363	-0.256	1.658	1.000	0.646	0.672	0.672	0.723	.	4.680	2.870	0.730	0.103	0.599	0.996	0.397	0.241	463	Bin3-type_S-adenosyl-L-methionine_binding_domain	.	.	ID=COSV52769750;OCCURENCE=1(large_intestine)	MEPCE	421	0	520	58	0.100346020761246	TRUE	TRUE
ENSG00000147485.13	.	BCM	GRCh38.p13	chr8	51320822	51320822	+	G	G	A	Missense_Mutation	SNP	ENST00000356297.5	exon22	c.C4222T	p.R1408C	exonic	ENSG00000147485.13	.	nonsynonymous SNV	ENSG00000147485.13:ENST00000356297.5:exon22:c.C4222T:p.R1408C	8q11.22	C3N-02573	3.313e-05	0.0001	0	0.0002	0.0002	0	0	0	rs537952252	5.19	D	D	D	P	.	N	M	T	D	0.144	T	T	T	0.241	0.540	0.352	0.161	T	T	T	T	T	T	1.641	16.640	0.987	N	N	-0.623	0.946	-0.843	0.699	0.000	0.554	0.574	0.618	0.564	.	4.430	0.333	0.014	-0.945	-0.633	0.000	0.000	0.003	900	VWFC_domain	.	.	ID=COSV62487421;OCCURENCE=2(large_intestine)	PXDNL	306	1	409	48	0.105032822757112	TRUE	TRUE
ENSG00000050555.18	.	BCM	GRCh38.p13	chr9	131061112	131061112	+	G	G	A	Missense_Mutation	SNP	ENST00000361069.9	exon13	c.G2236A	p.A746T	exonic	ENSG00000050555.18	.	nonsynonymous SNV	ENSG00000050555.18:ENST00000361069.9:exon13:c.G2236A:p.A746T	9q34.12	C3N-02573	.	.	.	.	.	.	.	.	rs900991986	0.20	T	T	B	B	N	N	N	T	N	0.102	T	T	T	0.016	0.489	0.216	0.141	T	T	T	T	T	T	-1.330	0.001	0.787	N	N	-1.829	0.021	-1.871	0.025	1.000	0.696	0.547	0.723	0.613	.	4.790	-8.570	-4.063	-0.623	-0.116	0.000	0.001	0.005	408	Laminin_EGF_domain	.	.	.	LAMC3	526	0	553	30	0.0514579759862779	TRUE	NA
ENSG00000198610.11	.	BCM	GRCh38.p13	chr10	5204429	5204429	+	C	C	A	Nonsense_Mutation	SNP	ENST00000380448.5	exon5	c.C305A	p.S102X	exonic	ENSG00000198610.11	.	stopgain	ENSG00000198610.11:ENST00000380448.5:exon5:c.C305A:p.S102X	10p15.1	C3N-02573	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.784	.	.	.	.	.	.	.	.	.	D	D	.	.	6.668	36	0.989	D	N	0.248	3.521	-0.049	2.199	0.032	0.487	0.574	0.574	0.564	.	3.130	2.170	5.120	0.925	0.549	1.000	0.008	0.374	982	NADP-dependent_oxidoreductase_domain	.	.	.	AKR1C4	173	0	245	36	0.128113879003559	TRUE	TRUE
ENSG00000095787.23	.	BCM	GRCh38.p13	chr10	28595997	28595997	+	C	C	G	Missense_Mutation	SNP	ENST00000354911.9	exon7	c.C875G	p.P292R	exonic	ENSG00000095787.23	.	nonsynonymous SNV	ENSG00000095787.23:ENST00000354911.9:exon7:c.C875G:p.P292R	10p12.1	C3N-02573	.	.	.	.	.	.	.	.	.	6.20	D	T	P	B	N	D	L	T	N	0.430	T	T	T	0.163	0.275	0.110	0.464	T	T	T	T	D	D	2.943	23.300	0.994	D	D	0.197	3.289	0.325	3.863	1.000	0.722	0.702	0.699	0.735	.	5.410	5.410	3.135	1.026	0.599	1.000	1.000	1.000	866	.	.	.	.	WAC	211	0	227	33	0.126923076923077	TRUE	TRUE
ENSG00000184014.8	.	BCM	GRCh38.p13	chr11	9204140	9204140	+	G	G	T	Missense_Mutation	SNP	ENST00000328194.8	exon4	c.C469A	p.H157N	exonic	ENSG00000184014.8	.	nonsynonymous SNV	ENSG00000184014.8:ENST00000328194.8:exon4:c.C469A:p.H157N	11p15.4	C3N-02573	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.894	T	T	T	0.306	0.314	0.501	1.281	D	T	T	T	D	D	3.894	26.300	0.993	D	D	0.960	12.709	0.948	15.985	1.000	0.719	0.698	0.780	0.734	.	5.810	5.810	10.003	1.176	0.676	1.000	1.000	0.999	492	Tripartite_DENN_domain	.	.	.	DENND5A	357	1	347	46	0.11704834605598	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-02573	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	288	1	371	52	0.122931442080378	TRUE	TRUE
ENSG00000167548.15	.	BCM	GRCh38.p13	chr12	49046408	49046408	+	G	G	A	Nonsense_Mutation	SNP	ENST00000301067.11	exon16	c.C4435T	p.Q1479X	exonic	ENSG00000167548.15	.	stopgain	ENSG00000167548.15:ENST00000301067.11:exon16:c.C4435T:p.Q1479X	12q13.12	C3N-02573	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.746	.	.	.	.	.	.	.	.	.	D	D	.	.	7.735	39	0.998	D	N	1.182	22.195	1.030	20.812	1.000	0.707	0.702	0.702	0.714	.	5.230	5.230	8.117	1.176	0.676	1.000	1.000	0.998	371	.	.	.	ID=COSV56434785;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	KMT2D	163	0	241	37	0.133093525179856	TRUE	TRUE
ENSG00000139618.15	.	BCM	GRCh38.p13	chr13	32370992	32370992	+	C	C	T	Missense_Mutation	SNP	ENST00000380152.7	exon20	c.C8524T	p.R2842C	exonic	ENSG00000139618.15	.	nonsynonymous SNV	ENSG00000139618.15:ENST00000380152.7:exon20:c.C8524T:p.R2842C	13q13.1	C3N-02573	.	.	.	.	.	.	.	.	rs80359104	13.15	D	D	.	.	D	D	.	D	N	0.738	D	D	D	0.843	.	0.945	0.179	T	.	D	D	D	.	4.136	28.100	0.999	D	D	0.705	7.184	0.667	7.180	1.000	0.732	0.654	0.744	0.684	.	5.100	5.100	4.630	1.026	0.549	1.000	1.000	0.999	723	.	.	.	ID=COSV66450665;OCCURENCE=5(breast),1(penis),1(oesophagus),1(large_intestine),2(biliary_tract),1(pancreas),1(skin),2(endometrium)	BRCA2	221	0	262	52	0.165605095541401	TRUE	TRUE
ENSG00000165355.7	.	BCM	GRCh38.p13	chr14	39431922	39431924	+	AGA	AGA	-	In_Frame_Del	DEL	ENST00000298097.7	exon1	c.239_241del	p.F80del	exonic	ENSG00000165355.7	.	nonframeshift deletion	ENSG00000165355.7:ENST00000298097.7:exon1:c.239_241del:p.F80del	14q21.1	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBXO33	186	0	184	49	0.210300429184549	TRUE	TRUE
ENSG00000103657.14	.	BCM	GRCh38.p13	chr15	63723223	63723223	+	C	C	T	Missense_Mutation	SNP	ENST00000443617.7	exon19	c.G3701A	p.R1234Q	exonic	ENSG00000103657.14	.	nonsynonymous SNV	ENSG00000103657.14:ENST00000443617.7:exon19:c.G3701A:p.R1234Q	15q22.31	C3N-02573	4.032e-05	0	0	0.0006	0	0	0	0	rs761166996	2.20	T	T	B	B	U	N	N	T	N	0.280	T	T	T	0.024	0.251	0.103	0.381	T	T	T	T	T	D	2.312	21.600	0.990	D	N	-0.593	1.000	-0.355	1.456	0.998	0.732	0.709	0.651	0.728	.	5.540	3.650	1.959	1.026	0.599	0.985	0.990	0.998	711	.	.	.	ID=COSV71246981;OCCURENCE=1(large_intestine)	HERC1	68	0	105	12	0.102564102564103	TRUE	TRUE
ENSG00000166855.9	.	BCM	GRCh38.p13	chr15	65179039	65179039	+	C	C	T	Missense_Mutation	SNP	ENST00000300107.7	exon3	c.G253A	p.E85K	exonic	ENSG00000166855.9	.	nonsynonymous SNV	ENSG00000166855.9:ENST00000300107.7:exon3:c.G253A:p.E85K	15q22.31	C3N-02573	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.199	T	T	T	0.092	0.264	0.210	0.566	T	T	T	T	D	D	2.099	20.100	0.998	D	D	0.022	2.590	0.171	3.043	1.000	0.707	0.725	0.725	0.714	.	4.970	4.970	4.316	1.026	0.599	1.000	0.917	0.413	627	.	.	.	.	CLPX	135	0	183	58	0.240663900414938	TRUE	TRUE
ENSG00000156218.13	.	BCM	GRCh38.p13	chr15	84025296	84025296	+	C	C	T	Missense_Mutation	SNP	ENST00000286744.10	exon27	c.C4516T	p.R1506W	exonic	ENSG00000156218.13	.	nonsynonymous SNV	ENSG00000156218.13:ENST00000286744.10:exon27:c.C4516T:p.R1506W	15q25.2	C3N-02573	2.5e-05	0	0	0	0	3.014e-05	0	6.44e-05	rs781474522	15.20	D	D	D	D	N	D	H	T	D	0.886	D	D	D	0.794	0.889	0.941	0.593	T	T	D	D	D	T	3.478	24.600	0.999	D	D	0.890	10.787	0.769	9.267	0.965	0.638	0.670	0.602	0.613	.	5.150	5.150	2.076	1.026	0.599	1.000	0.998	0.904	634	.	.	.	.	ADAMTSL3	116	0	188	28	0.12962962962963	TRUE	NA
ENSG00000172831.14	.	BCM	GRCh38.p13	chr16	66941161	66941161	+	C	C	G	Missense_Mutation	SNP	ENST00000317091.10	exon6	c.C854G	p.S285C	exonic	ENSG00000172831.14	.	nonsynonymous SNV	ENSG00000172831.14:ENST00000317091.10:exon6:c.C854G:p.S285C	16q22.1	C3N-02573	1.649e-05	0	0	0.0001	0	1.5e-05	0	0	rs756554216	12.16	D	D	.	.	D	D	.	T	D	0.348	D	D	D	0.414	.	0.801	0.702	T	.	T	T	D	D	3.475	24.600	0.799	D	D	0.864	10.166	0.754	8.890	1.000	0.732	0.702	0.744	0.714	.	5.400	5.400	5.297	1.000	0.599	0.945	0.258	0.631	140	.	.	.	.	CES2	197	0	314	37	0.105413105413105	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675232	7675232	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.C380T	p.S127F	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.C380T:p.S127F	17p13.1	C3N-02573	.	.	.	.	.	.	.	.	rs730881999	19.20	D	D	D	D	D	D	M	D	D	0.959	D	D	D	0.925	0.837	0.988	1.738	T	D	D	D	D	D	4.098	27.700	0.997	D	D	0.881	10.572	0.796	10.009	1.000	0.722	0.702	0.698	0.735	.	5.480	4.510	9.948	1.176	0.676	1.000	0.792	0.922	434	p53,_DNA-binding_domain	.	.	ID=COSV52666031;OCCURENCE=1(salivary_gland),6(breast),2(liver),4(oesophagus),18(large_intestine),8(central_nervous_system),3(biliary_tract),6(ovary),2(bone),8(NS),4(stomach),4(urinary_tract),8(pancreas),11(skin),7(lung),1(thyroid),6(upper_aerodigestive_tract),2(small_intestine),3(endometrium)	TP53	294	0	329	44	0.117962466487936	TRUE	TRUE
ENSG00000120088.15	.	BCM	GRCh38.p13	chr17	45834678	45834678	+	C	C	T	Missense_Mutation	SNP	ENST00000398285.7	exon14	c.C1249T	p.R417C	exonic	ENSG00000120088.15;ENSG00000263715.7	.	nonsynonymous SNV	ENSG00000120088.15:ENST00000398285.7:exon14:c.C1249T:p.R417C,ENSG00000263715.7:ENST00000634540.1:exon15:c.C637T:p.R213C	17q21.31	C3N-02573	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.785	T	T	D	0.467	0.596	0.738	1.756	D	D	D	D	D	D	4.220	28.800	0.999	D	D	0.623	6.164	0.568	5.842	0.917	0.646	0.590	0.645	0.613	.	5.240	4.250	6.157	0.074	0.599	1.000	0.517	0.897	611	.	.	.	ID=COSV99524313;OCCURENCE=1(upper_aerodigestive_tract)	CRHR1	191	0	254	39	0.133105802047782	TRUE	NA
ENSG00000167280.17	.	BCM	GRCh38.p13	chr17	79083911	79083911	+	C	C	T	Missense_Mutation	SNP	ENST00000579016.6	exon10	c.C1402T	p.R468W	exonic	ENSG00000167280.17	.	nonsynonymous SNV	ENSG00000167280.17:ENST00000579016.6:exon10:c.C1402T:p.R468W	17q25.3	C3N-02573	0.0002	0.0013	0	0.0002	0	7.748e-05	0	0	rs369232286	7.18	.	D	D	B	N	N	M	T	.	0.481	T	T	D	0.329	.	0.348	0.472	T	T	T	T	T	D	2.803	23.000	0.999	D	D	-0.071	2.270	-0.164	1.874	0.939	0.672	0.702	0.723	0.636	.	4.820	3.820	3.494	1.026	0.599	1.000	0.035	0.022	917	.	.	.	ID=COSV56134889;OCCURENCE=1(stomach)	ENGASE	398	1	489	67	0.120503597122302	TRUE	TRUE
ENSG00000212710.5	.	BCM	GRCh38.p13	chr18	22416199	22416199	+	T	T	G	Missense_Mutation	SNP	ENST00000391403.4	exon1	c.A1613C	p.Q538P	exonic	ENSG00000212710.5	.	nonsynonymous SNV	ENSG00000212710.5:ENST00000391403.4:exon1:c.A1613C:p.Q538P	18q11.2	C3N-02573	.	.	.	.	.	.	.	.	.	1.18	T	T	B	B	.	N	M	T	N	0.192	T	T	T	0.035	0.169	0.110	0.008	T	T	T	T	T	.	0.710	8.545	0.744	N	N	-0.858	0.574	-0.963	0.537	0.004	0.554	0.588	0.618	0.564	.	0.779	0.779	1.333	0.270	0.462	0.955	0.018	0.009	910	.	.	.	.	CTAGE1	458	1	443	121	0.214539007092199	NA	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51067035	51067035	+	G	G	T	Missense_Mutation	SNP	ENST00000342988.8	exon10	c.G1156T	p.G386C	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon10:c.G1156T:p.G386C	18q21.2	C3N-02573	.	.	.	.	.	.	.	.	rs1057519962	20.20	D	D	D	D	D	D	H	D	D	0.971	D	D	D	0.972	0.901	0.988	2.936	D	D	D	D	D	D	4.545	32	0.996	D	D	0.962	12.780	0.871	12.562	1.000	0.732	0.744	0.725	0.714	.	5.650	4.780	9.889	1.176	0.676	1.000	1.000	0.999	892	SMAD_domain,_Dwarfin-type	.	.	ID=COSV61697840;OCCURENCE=2(large_intestine),1(ovary)	SMAD4	295	0	344	50	0.126903553299492	TRUE	TRUE
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8081016	8081016	+	G	G	T	Missense_Mutation	SNP	ENST00000600128.6	exon59	c.C7440A	p.H2480Q	exonic	ENSG00000142449.13	.	nonsynonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon59:c.C7440A:p.H2480Q	19p13.2	C3N-02573	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	U	N	N	D	D	0.185	T	T	D	0.336	0.486	0.770	0.214	T	T	T	T	D	T	2.796	23.000	0.985	D	N	-0.227	1.803	-0.187	1.817	0.983	0.696	0.574	0.723	0.564	.	3.910	2.820	1.567	0.996	0.606	1.000	0.903	0.916	744	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	FBN3	336	0	392	56	0.125	TRUE	TRUE
ENSG00000100412.16	.	BCM	GRCh38.p13	chr22	41525322	41525322	+	C	C	G	Missense_Mutation	SNP	ENST00000216254.9	exon14	c.C1735G	p.L579V	exonic	ENSG00000100412.16	.	nonsynonymous SNV	ENSG00000100412.16:ENST00000216254.9:exon14:c.C1735G:p.L579V	22q13.2	C3N-02573	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	M	T	N	0.620	T	T	D	0.159	0.291	0.515	0.725	T	T	T	T	D	D	1.730	17.240	0.989	D	D	-0.179	1.935	-0.101	2.043	1.000	0.672	0.702	0.702	0.711	.	5.870	1.430	3.136	0.127	-0.175	1.000	0.998	0.979	98	.	.	.	.	ACO2	221	0	233	87	0.271875	TRUE	TRUE
ENSG00000196576.15	.	BCM	GRCh38.p13	chr22	50287151	50287151	+	G	G	C	Missense_Mutation	SNP	ENST00000359337.9	exon8	c.C1722G	p.C574W	exonic	ENSG00000196576.15	.	nonsynonymous SNV	ENSG00000196576.15:ENST00000359337.9:exon8:c.C1722G:p.C574W	22q13.33	C3N-02573	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	N	D	H	T	D	0.823	T	T	D	0.299	0.850	0.875	1.184	T	D	D	D	D	T	2.926	23.300	0.993	N	N	-0.095	2.192	-0.332	1.500	0.693	0.672	0.702	0.723	0.711	.	4.600	-1.400	0.433	0.245	0.676	0.985	0.518	0.065	620	.	.	.	.	PLXNB2	85	0	109	31	0.221428571428571	TRUE	TRUE
ENSG00000130741.11	.	BCM	GRCh38.p13	chrX	24068043	24068043	+	C	C	A	Missense_Mutation	SNP	ENST00000253039.9	exon9	c.C947A	p.S316Y	exonic	ENSG00000130741.11	.	nonsynonymous SNV	ENSG00000130741.11:ENST00000253039.9:exon9:c.C947A:p.S316Y	Xp22.11	C3N-02573	.	.	.	.	.	.	.	.	.	17.18	D	D	D	D	D	D	.	T	D	0.833	D	D	D	0.674	0.747	0.969	3.504	D	D	D	D	D	D	3.870	26.200	0.995	D	.	.	.	.	.	1.000	.	.	.	.	.	5.240	5.240	7.466	1.015	0.589	1.000	1.000	1.000	242	Translation_elongation_factor_EFTu-like,_domain_2	.	.	.	EIF2S3	71	0	105	7	0.0625	NA	TRUE
ENSG00000198173.5	.	BCM	GRCh38.p13	chrX	37011208	37011208	+	A	A	T	Missense_Mutation	SNP	ENST00000358047.5	exon1	c.A2798T	p.H933L	exonic	ENSG00000198173.5	.	nonsynonymous SNV	ENSG00000198173.5:ENST00000358047.5:exon1:c.A2798T:p.H933L	Xp21.1	C3N-02573	.	.	.	.	.	.	.	.	.	1.18	T	T	B	B	.	N	L	T	D	0.140	T	T	T	0.031	0.393	0.115	0.227	T	T	T	T	T	T	-0.665	0.052	0.289	N	.	.	.	.	.	0.039	.	.	.	.	.	0.484	-0.967	-1.040	-1.288	-1.646	0.013	0.001	0.001	889	.	.	.	.	FAM47C	123	0	125	14	0.100719424460432	TRUE	TRUE
ENSG00000147041.12	.	BCM	GRCh38.p13	chrX	38073623	38073623	+	G	G	A	Missense_Mutation	SNP	ENST00000297875.7	exon5	c.G479A	p.R160H	exonic	ENSG00000147041.12	.	nonsynonymous SNV	ENSG00000147041.12:ENST00000297875.7:exon5:c.G479A:p.R160H	Xp11.4	C3N-02573	0.0010	0.0073	0.0018	0	0	0	0	0	rs149390993	0.19	T	T	B	B	N	N	N	T	N	0.056	T	T	T	0.014	.	0.088	0.041	T	T	T	T	T	T	-0.822	0.022	0.690	N	.	.	.	.	.	1.000	.	.	.	.	.	5.530	-9.070	-2.693	-0.478	0.676	0.000	0.001	0.821	719	.	.	.	.	SYTL5	146	0	195	27	0.121621621621622	TRUE	NA
ENSG00000147044.21	.	BCM	GRCh38.p13	chrX	41853162	41853162	+	A	A	C	Missense_Mutation	SNP	ENST00000378163.6	exon2	c.T125G	p.I42S	exonic	ENSG00000147044.21	.	nonsynonymous SNV	ENSG00000147044.21:ENST00000378163.6:exon2:c.T125G:p.I42S	Xp11.4	C3N-02573	.	.	.	.	.	.	.	.	.	13.19	T	T	D	D	D	D	M	T	D	0.946	T	T	D	0.560	0.810	0.985	2.391	D	T	D	D	D	D	3.273	24.000	0.993	D	.	.	.	.	.	1.000	.	.	.	.	.	5.320	5.320	8.845	1.312	0.756	1.000	1.000	1.000	832	Protein_kinase_domain	.	.	.	CASK	228	1	309	49	0.136871508379888	TRUE	TRUE
ENSG00000187690.4	.	BCM	GRCh38.p13	chrX	51407926	51407926	+	C	C	T	Missense_Mutation	SNP	ENST00000342995.4	exon1	c.C910T	p.R304C	exonic	ENSG00000187690.4	.	nonsynonymous SNV	ENSG00000187690.4:ENST00000342995.4:exon1:c.C910T:p.R304C	Xp11.22	C3N-02573	.	.	.	.	.	.	.	.	.	4.17	D	D	P	B	N	N	.	T	D	0.119	T	T	T	0.098	0.265	0.117	0.285	.	T	T	T	D	T	1.621	16.510	0.964	N	.	.	.	.	.	0.025	.	.	.	.	.	3.260	-1.490	0.468	0.832	-0.242	0.001	0.006	0.000	242	.	.	.	.	EZHIP	617	2	645	70	0.0979020979020979	TRUE	TRUE
ENSG00000086758.16	.	BCM	GRCh38.p13	chrX	53552643	53552643	+	C	C	A	Missense_Mutation	SNP	ENST00000262854.11	exon62	c.G8745T	p.E2915D	exonic	ENSG00000086758.16	.	nonsynonymous SNV	ENSG00000086758.16:ENST00000262854.11:exon62:c.G8745T:p.E2915D	Xp11.22	C3N-02573	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	N	T	N	0.097	T	T	T	0.109	0.096	0.555	0.850	T	T	T	T	T	T	0.982	11.400	0.856	D	.	.	.	.	.	1.000	.	.	.	.	.	6.080	2.220	0.151	-0.624	-0.186	0.991	0.971	0.920	1	.	.	.	.	HUWE1	434	0	491	56	0.102376599634369	TRUE	TRUE
ENSG00000086758.16	.	BCM	GRCh38.p13	chrX	53607560	53607560	+	G	G	C	Missense_Mutation	SNP	ENST00000262854.11	exon25	c.C2459G	p.A820G	exonic	ENSG00000086758.16	.	nonsynonymous SNV	ENSG00000086758.16:ENST00000262854.11:exon25:c.C2459G:p.A820G	Xp11.22	C3N-02573	.	.	.	.	.	.	.	.	.	9.19	D	T	P	B	D	D	M	T	D	0.608	T	T	D	0.276	0.526	0.801	1.840	T	T	T	T	D	D	3.065	23.600	0.996	D	.	.	.	.	.	1.000	.	.	.	.	.	5.390	5.390	9.128	1.176	0.676	1.000	1.000	1.000	1	.	.	.	.	HUWE1	136	0	178	15	0.077720207253886	TRUE	TRUE
ENSG00000075461.6	.	BCM	GRCh38.p13	chr17	67018273	67018273	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000075461.6	ENST00000262138.4:exon2:c.304+1G>A	.	.	17q24.2	C3N-02573	1.651e-05	0	0	0	0	1.501e-05	0	6.073e-05	rs774987460	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.030	35	0.995	D	.	1.166	21.063	1.004	19.114	1.000	0.078	0.080	0.065	0.059	0.983	4.890	4.890	9.463	1.176	0.676	1.000	0.994	0.925	634	.	.	.	.	CACNG4	156	0	219	21	0.0875	TRUE	NA
ENSG00000174827.14	.	BCM	GRCh38.p13	chr1	145686667	145686667	+	A	A	G	Silent	SNP	ENST00000417171.6	exon3	c.T270C	p.D90D	exonic	ENSG00000174827.14	.	synonymous SNV	ENSG00000174827.14:ENST00000417171.6:exon3:c.T270C:p.D90D	1q21.1	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDZK1	95	0	126	16	0.112676056338028	NA	TRUE
ENSG00000075340.23	.	BCM	GRCh38.p13	chr2	70663656	70663656	+	G	G	A	Silent	SNP	ENST00000264436.9	exon16	c.C1950T	p.N650N	exonic	ENSG00000075340.23	.	synonymous SNV	ENSG00000075340.23:ENST00000264436.9:exon16:c.C1950T:p.N650N	2p13.3	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52458845;OCCURENCE=1(large_intestine),1(stomach),1(pancreas),1(prostate)	ADD2	340	0	380	54	0.124423963133641	TRUE	TRUE
ENSG00000114786.16	.	BCM	GRCh38.p13	chr3	51987367	51987367	+	C	C	T	Silent	SNP	ENST00000636358.2	exon11	c.C766T	p.L256L	exonic	ENSG00000114786.16;ENSG00000243989.9	.	synonymous SNV	ENSG00000243989.9:ENST00000636358.2:exon11:c.C766T:p.L256L,ENSG00000114786.16:ENST00000463937.1:exon12:c.C1069T:p.L357L	3p21.2	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABHD14A-ACY1	330	0	356	39	0.0987341772151899	TRUE	TRUE
ENSG00000215262.8	.	BCM	GRCh38.p13	chr8	36931139	36931139	+	C	C	T	Silent	SNP	ENST00000399881.8	exon25	c.C2925T	p.D975D	exonic	ENSG00000215262.8	.	synonymous SNV	ENSG00000215262.8:ENST00000399881.8:exon25:c.C2925T:p.D975D	8p11.23	C3N-02573	0.0046	0.0217	0.0015	0.0001	0	0.0003	0.0011	0.0196	rs60599552	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67757797;OCCURENCE=1(large_intestine)	KCNU1	53	0	71	13	0.154761904761905	TRUE	TRUE
ENSG00000059915.17	.	BCM	GRCh38.p13	chr10	102416757	102416757	+	G	G	A	Silent	SNP	ENST00000020673.6	exon2	c.C282T	p.P94P	exonic	ENSG00000059915.17	.	synonymous SNV	ENSG00000059915.17:ENST00000020673.6:exon2:c.C282T:p.P94P	10q24.32	C3N-02573	4.543e-05	0	0	0.0004	0	3.223e-05	0	0	rs767634674	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PSD	86	0	112	26	0.188405797101449	TRUE	NA
ENSG00000108018.15	.	BCM	GRCh38.p13	chr10	106956530	106956530	+	T	T	C	Silent	SNP	ENST00000263054.10	exon2	c.A609G	p.T203T	exonic	ENSG00000108018.15	.	synonymous SNV	ENSG00000108018.15:ENST00000263054.10:exon2:c.A609G:p.T203T	10q25.1	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SORCS1	116	0	187	17	0.0833333333333333	TRUE	TRUE
ENSG00000010292.13	.	BCM	GRCh38.p13	chr12	6514803	6514803	+	G	G	C	Silent	SNP	ENST00000315579.10	exon9	c.G870C	p.L290L	exonic	ENSG00000010292.13	.	synonymous SNV	ENSG00000010292.13:ENST00000315579.10:exon9:c.G870C:p.L290L	12p13.31	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NCAPD2	164	0	220	25	0.102040816326531	TRUE	TRUE
ENSG00000119596.18	.	BCM	GRCh38.p13	chr14	74763969	74763969	+	A	A	C	Silent	SNP	ENST00000325680.12	exon1	c.A480C	p.P160P	exonic	ENSG00000119596.18	.	synonymous SNV	ENSG00000119596.18:ENST00000325680.12:exon1:c.A480C:p.P160P	14q24.3	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	YLPM1	55	0	38	6	0.136363636363636	TRUE	NA
ENSG00000169696.16	.	BCM	GRCh38.p13	chr17	81985530	81985530	+	C	C	T	Silent	SNP	ENST00000306739.9	exon4	c.C297T	p.D99D	exonic	ENSG00000169696.16	.	synonymous SNV	ENSG00000169696.16:ENST00000306739.9:exon4:c.C297T:p.D99D	17q25.3	C3N-02573	8.288e-06	0	0	0	0	1.512e-05	0	0	rs748292573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ASPSCR1	248	0	305	40	0.115942028985507	TRUE	NA
ENSG00000130270.16	.	BCM	GRCh38.p13	chr19	1796784	1796784	+	G	G	A	Silent	SNP	ENST00000310127.10	exon16	c.C1680T	p.A560A	exonic	ENSG00000130270.16	.	synonymous SNV	ENSG00000130270.16:ENST00000310127.10:exon16:c.C1680T:p.A560A	19p13.3	C3N-02573	0.0001	0	8.826e-05	0	0	0.0002	0	6.099e-05	rs764850311	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP8B3	408	0	482	62	0.113970588235294	TRUE	NA
ENSG00000196090.12	.	BCM	GRCh38.p13	chr20	42199319	42199319	+	G	G	A	Silent	SNP	ENST00000373187.5	exon16	c.C2412T	p.A804A	exonic	ENSG00000196090.12	.	synonymous SNV	ENSG00000196090.12:ENST00000373187.5:exon16:c.C2412T:p.A804A	20q12	C3N-02573	0.0001	0	0	0.0003	0	0.0002	0	6.056e-05	rs368232579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTPRT	254	0	311	28	0.0825958702064897	TRUE	NA
ENSG00000231672.7	.	BCM	GRCh38.p13	chr2	217756067	217756067	+	C	C	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000231672.7	.	.	.	2q35	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DIRC3	251	0	370	26	0.0656565656565657	TRUE	TRUE
ENSG00000163576.18	.	BCM	GRCh38.p13	chr3	19936288	19936288	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000163576.18;ENSG00000232953.1	dist=2071;dist=3981	.	.	3p24.3	C3N-02573	.	.	.	.	.	.	.	.	rs994695408	1.16	D	T	B	B	.	N	.	T	N	0.043	T	T	T	0.042	0.441	0.055	.	.	.	T	T	T	T	-0.216	0.472	0.620	N	N	-1.618	0.051	-1.723	0.047	0.997	0.554	0.588	0.547	0.621	.	1.270	-2.540	-0.942	-0.698	-1.297	0.008	0.012	0.001	759	.	.	.	.	EFHB	58	0	62	11	0.150684931506849	TRUE	NA
ENSG00000247925.2	.	BCM	GRCh38.p13	chr6	11201022	11201022	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000247925.2	.	.	.	6p24.2	C3N-02573	.	.	.	.	.	.	.	.	.	0.14	T	T	.	.	.	N	.	T	N	0.068	T	T	T	0.039	0.422	0.279	.	.	.	T	T	T	T	-0.391	0.200	0.896	N	N	-1.262	0.187	-1.366	0.169	1.000	0.503	0.577	0.547	0.655	.	4.350	-3.340	-1.489	-0.163	-0.232	0.000	0.203	0.068	808	.	.	.	.	AL139807.1	233	0	292	30	0.093167701863354	TRUE	TRUE
ENSG00000212443.1	.	BCM	GRCh38.p13	chr12	98599746	98599746	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000212443.1	.	.	.	12q23.1	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SNORA53	289	0	348	19	0.0517711171662125	TRUE	NA
ENSG00000208027.4	.	BCM	GRCh38.p13	chr14	101055472	101055472	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000208027.4	.	.	.	14q32.31	C3N-02573	3.315e-05	0	0	0	0	4.529e-05	0	6.115e-05	rs751189950	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR485	104	0	104	26	0.2	TRUE	NA
ENSG00000157890.17	.	BCM	GRCh38.p13	chr15	65916616	65916616	+	C	C	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000157890.17	.	.	.	15q22.31	C3N-02573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MEGF11	51	0	65	17	0.207317073170732	TRUE	NA
ENSG00000235590.7	.	BCM	GRCh38.p13	chr20	58840572	58840572	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000235590.7	.	.	.	20q13.32	C3N-02573	2.513e-05	9.872e-05	0	0	0	3.062e-05	0	0	rs776413759	0.18	T	T	P	B	.	N	N	.	N	0.228	T	T	T	0.083	.	0.103	.	T	T	T	T	T	T	1.688	16.950	0.982	N	N	-0.753	0.725	-0.673	0.939	1.000	0.598	0.627	0.504	0.639	.	5.080	-0.070	0.926	-0.548	-0.242	0.990	0.003	0.480	959	.	.	.	ID=COSV58342706;OCCURENCE=1(endometrium)	GNAS-AS1	216	0	240	36	0.130434782608696	TRUE	NA
ENSG00000116138.13	.	BCM	GRCh38.p13	chr1	15529262	15529262	+	G	G	A	Missense_Mutation	SNP	ENST00000375847.8	exon2	c.G157A	p.A53T	exonic	ENSG00000116138.13	.	nonsynonymous SNV	ENSG00000116138.13:ENST00000375847.8:exon2:c.G157A:p.A53T	1p36.21	C3L-00819	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	D	D	M	T	D	0.751	T	T	T	0.381	.	0.620	0.611	T	T	D	D	D	D	4.159	28.300	0.999	D	D	0.883	10.610	0.861	12.170	1.000	0.651	0.624	0.659	0.684	.	5.650	5.650	8.090	1.167	0.676	1.000	1.000	1.000	905	DnaJ_domain	.	.	ID=COSV61600805;OCCURENCE=1(large_intestine)	DNAJC16	155	0	69	14	0.168674698795181	TRUE	TRUE
ENSG00000143569.19	.	BCM	GRCh38.p13	chr1	154255745	154255745	+	C	C	T	Missense_Mutation	SNP	ENST00000428931.6	exon18	c.C2147T	p.S716F	exonic	ENSG00000143569.19	.	nonsynonymous SNV	ENSG00000143569.19:ENST00000428931.6:exon18:c.C2147T:p.S716F	1q21.3	C3L-00819	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	D	0.814	T	T	D	0.375	0.390	0.238	0.155	T	D	D	T	D	D	4.090	27.700	0.995	D	D	0.653	6.506	0.673	7.272	1.000	0.707	0.702	0.702	0.714	.	5.460	5.460	5.305	1.010	0.580	1.000	0.999	0.996	144	.	.	.	.	UBAP2L	264	0	239	44	0.15547703180212	TRUE	TRUE
ENSG00000163357.11	.	BCM	GRCh38.p13	chr1	155041428	155041428	+	G	G	A	Missense_Mutation	SNP	ENST00000295542.6	exon7	c.G563A	p.R188Q	exonic	ENSG00000163357.11	.	nonsynonymous SNV	ENSG00000163357.11:ENST00000295542.6:exon7:c.G563A:p.R188Q	1q21.3	C3L-00819	8.431e-06	0.0001	0	0	0	0	0	0	rs750570779	1.20	T	T	B	B	N	N	N	T	N	0.124	T	T	D	0.057	0.372	0.312	0.134	T	T	T	T	T	T	-0.636	0.061	0.806	N	N	-1.849	0.019	-1.802	0.034	1.000	0.497	0.590	0.547	0.613	.	4.290	-5.060	-0.920	0.207	-0.194	0.000	0.879	0.259	234	.	.	.	.	DCST1	306	0	739	107	0.126477541371158	TRUE	NA
ENSG00000115705.22	.	BCM	GRCh38.p13	chr2	1493885	1493885	+	G	G	A	Missense_Mutation	SNP	ENST00000329066.9	exon11	c.G1852A	p.V618M	exonic	ENSG00000115705.22	.	nonsynonymous SNV	ENSG00000115705.22:ENST00000329066.9:exon11:c.G1852A:p.V618M	2p25.3	C3L-00819	0.0157	0.1694	0.0082	0	0.0002	0.0005	0.0111	0.0005	rs10189135	1.19	T	T	P	B	N	P	L	T	N	0.123	T	T	.	0.210	.	.	0.356	T	T	T	T	D	T	0.578	7.295	0.971	N	N	-0.936	0.476	-1.197	0.285	1.000	0.554	0.588	0.578	0.613	.	4.840	-8.980	-1.554	-0.186	0.672	0.000	0.001	0.031	889	.	.	.	.	TPO	410	0	1027	165	0.138422818791946	TRUE	NA
ENSG00000115507.10	.	BCM	GRCh38.p13	chr2	63054109	63054109	+	G	G	A	Missense_Mutation	SNP	ENST00000282549.7	exon4	c.G160A	p.E54K	exonic	ENSG00000115507.10	.	nonsynonymous SNV	ENSG00000115507.10:ENST00000282549.7:exon4:c.G160A:p.E54K	2p15	C3L-00819	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.881	D	D	D	0.958	0.886	0.978	.	D	D	D	D	D	D	4.676	32	0.993	D	D	0.936	12.015	0.866	12.385	1.000	0.564	0.552	0.504	0.555	.	4.790	4.790	9.940	1.176	0.676	1.000	0.988	0.997	327	Homeobox_domain	.	.	.	OTX1	132	0	504	76	0.131034482758621	TRUE	TRUE
ENSG00000196834.12	.	BCM	GRCh38.p13	chr2	130508961	130508961	+	T	T	G	Missense_Mutation	SNP	ENST00000451531.6	exon1	c.A275C	p.K92T	exonic	ENSG00000196834.12	.	nonsynonymous SNV	ENSG00000196834.12:ENST00000451531.6:exon1:c.A275C:p.K92T	2q21.1	C3L-00819	.	.	.	.	.	.	.	.	.	2.17	D	D	.	.	.	N	L	T	N	0.273	T	T	T	0.231	0.384	0.187	.	T	T	T	T	T	T	2.183	20.700	0.990	N	N	-0.504	1.170	-0.682	0.926	0.000	0.487	0.574	0.574	0.564	.	0.700	0.700	0.475	0.265	0.223	0.455	0.001	0.002	976	.	.	.	.	POTEI	660	1	1793	281	0.135486981677917	NA	TRUE
ENSG00000153253.18	.	BCM	GRCh38.p13	chr2	165140812	165140812	+	G	G	A	Nonsense_Mutation	SNP	ENST00000360093.7	exon13	c.C1858T	p.R620X	exonic	ENSG00000153253.18	.	stopgain	ENSG00000153253.18:ENST00000360093.7:exon13:c.C1858T:p.R620X	2q24.3	C3L-00819	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.935	.	.	.	.	.	.	.	.	.	D	D	.	.	7.474	38	0.998	D	N	0.746	7.807	0.627	6.583	0.977	0.487	0.547	0.574	0.530	.	6.070	5.190	2.172	1.176	0.676	1.000	1.000	0.998	849	Voltage-gated_Na+_ion_channel,_cytoplasmic_domain	.	.	ID=COSV51800546;OCCURENCE=3(large_intestine),1(endometrium)	SCN3A	292	0	498	77	0.133913043478261	TRUE	TRUE
ENSG00000231192.2	.	BCM	GRCh38.p13	chr3	98133281	98133281	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000641874.1	exon2	c.585dupT	p.L197Sfs*35	exonic	ENSG00000231192.2	.	frameshift insertion	ENSG00000231192.2:ENST00000641874.1:exon2:c.585dupT:p.L197Sfs*35	3q11.2	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR5H1	NA	NA	NA	NA	NA	NA	NA
ENSG00000173230.15	.	BCM	GRCh38.p13	chr3	121664563	121664563	+	G	G	A	Missense_Mutation	SNP	ENST00000340645.9	exon22	c.C9697T	p.R3233W	exonic	ENSG00000173230.15	.	nonsynonymous SNV	ENSG00000173230.15:ENST00000340645.9:exon22:c.C9697T:p.R3233W	3q13.33	C3L-00819	4.12e-05	0	0	0	0	5.996e-05	0	6.057e-05	rs745651336	13.20	D	D	D	D	D	D	L	T	D	0.812	T	T	D	0.348	0.483	0.789	0.535	T	T	T	D	D	D	4.520	32	0.998	D	D	0.637	6.320	0.655	6.986	1.000	0.732	0.725	0.744	0.711	.	5.640	5.640	3.029	1.176	0.676	1.000	0.998	0.994	387	.	.	.	ID=COSV58859217;OCCURENCE=1(endometrium)	GOLGB1	227	0	356	71	0.166276346604215	TRUE	TRUE
ENSG00000145198.14	.	BCM	GRCh38.p13	chr3	184233280	184233280	+	G	G	A	Missense_Mutation	SNP	ENST00000426955.6	exon3	c.G413A	p.R138Q	exonic	ENSG00000145198.14	.	nonsynonymous SNV	ENSG00000145198.14:ENST00000426955.6:exon3:c.G413A:p.R138Q	3q27.1	C3L-00819	7.149e-05	0	0	0	0	0	0	0.0002	rs765197607	2.17	T	T	.	.	.	D	N	T	N	0.091	T	T	T	0.052	0.312	0.145	0.705	T	T	T	T	T	T	2.173	20.700	0.995	D	N	-0.454	1.269	-0.269	1.628	0.061	0.598	0.590	0.596	0.530	.	4.370	3.490	1.492	1.176	0.676	1.000	1.000	0.995	884	VIT_domain	.	.	.	VWA5B2	91	0	311	47	0.131284916201117	TRUE	NA
ENSG00000145147.20	.	BCM	GRCh38.p13	chr4	20567313	20567313	+	C	C	T	Missense_Mutation	SNP	ENST00000504154.6	exon27	c.C2777T	p.P926L	exonic	ENSG00000145147.20	.	nonsynonymous SNV	ENSG00000145147.20:ENST00000504154.6:exon27:c.C2777T:p.P926L	4p15.31	C3L-00819	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.917	D	D	D	0.946	0.834	0.930	0.954	D	D	D	D	D	D	3.994	26.900	0.999	D	D	0.983	13.388	0.919	14.607	1.000	0.693	0.574	0.659	0.564	.	5.670	5.670	7.905	1.026	0.599	1.000	0.990	0.964	808	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	ID=COSV56596750;OCCURENCE=1(large_intestine),1(skin)	SLIT2	132	0	109	10	0.0840336134453782	TRUE	TRUE
ENSG00000178187.7	.	BCM	GRCh38.p13	chr5	178965447	178965447	+	G	G	A	Missense_Mutation	SNP	ENST00000320129.7	exon5	c.G1043A	p.R348K	exonic	ENSG00000178187.7	.	nonsynonymous SNV	ENSG00000178187.7:ENST00000320129.7:exon5:c.G1043A:p.R348K	5q35.3	C3L-00819	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	D	N	N	T	N	0.332	T	T	T	0.103	0.618	0.310	1.021	T	T	T	T	D	T	2.516	22.500	0.990	N	N	-0.148	2.028	-0.117	1.999	0.012	0.554	0.574	0.618	0.568	.	4.210	4.210	2.161	1.007	0.590	0.043	1.000	0.998	793	Zinc_finger_C2H2-type	.	.	.	ZNF454	143	0	145	29	0.166666666666667	TRUE	TRUE
ENSG00000146197.9	.	BCM	GRCh38.p13	chr6	35244678	35244678	+	C	C	G	Missense_Mutation	SNP	ENST00000274938.8	exon18	c.C2268G	p.N756K	exonic	ENSG00000146197.9	.	nonsynonymous SNV	ENSG00000146197.9:ENST00000274938.8:exon18:c.C2268G:p.N756K	6p21.31	C3L-00819	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.641	T	T	D	0.385	0.775	0.554	1.134	T	T	T	T	D	D	3.039	23.500	0.998	D	D	0.408	4.391	0.320	3.835	0.999	0.563	0.547	0.602	0.636	.	5.670	2.960	2.205	-0.232	-0.860	1.000	0.958	0.921	248	Tyrosine-protein_kinase_ephrin_type_A/B_receptor-like;EGF-like_domain	.	.	.	SCUBE3	159	0	319	58	0.153846153846154	TRUE	TRUE
ENSG00000112159.12	.	BCM	GRCh38.p13	chr6	89680645	89680645	+	G	G	A	Missense_Mutation	SNP	ENST00000369393.8	exon74	c.C12209T	p.T4070M	exonic	ENSG00000112159.12	.	nonsynonymous SNV	ENSG00000112159.12:ENST00000369393.8:exon74:c.C12209T:p.T4070M	6q15	C3L-00819	.	.	.	.	.	.	.	.	.	1.19	T	.	P	B	N	N	M	T	N	0.077	T	T	T	0.019	0.274	0.147	0.310	T	T	T	T	T	T	0.530	6.816	0.739	N	N	-0.939	0.473	-1.021	0.464	0.659	0.646	0.654	0.696	0.636	.	5.020	-0.614	0.538	-0.113	-0.119	0.001	0.000	0.001	803	.	.	.	ID=COSV65534599;OCCURENCE=1(large_intestine)	MDN1	208	0	540	61	0.101497504159734	TRUE	NA
ENSG00000135333.14	.	BCM	GRCh38.p13	chr6	93255954	93255954	+	C	C	G	Missense_Mutation	SNP	ENST00000369303.9	exon13	c.G2256C	p.M752I	exonic	ENSG00000135333.14	.	nonsynonymous SNV	ENSG00000135333.14:ENST00000369303.9:exon13:c.G2256C:p.M752I	6q16.1	C3L-00819	.	.	.	.	.	.	.	.	.	13.20	D	D	P	P	D	D	N	D	D	0.647	T	T	D	0.639	0.741	0.744	0.589	D	T	D	D	D	T	3.502	24.700	0.997	D	D	0.340	3.991	0.479	4.977	0.999	0.638	0.574	0.653	0.504	.	5.750	5.750	6.130	1.026	0.599	1.000	1.000	0.996	960	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	EPHA7	318	0	257	23	0.0821428571428571	TRUE	TRUE
ENSG00000104714.14	.	BCM	GRCh38.p13	chr8	673930	673931	+	CT	CT	-	Frame_Shift_Del	DEL	ENST00000262109.8	exon4	c.421_422del	p.L142Vfs*19	exonic	ENSG00000104714.14	.	frameshift deletion	ENSG00000104714.14:ENST00000262109.8:exon4:c.421_422del:p.L142Vfs*19	8p23.3	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ERICH1	318	0	300	40	0.117647058823529	TRUE	TRUE
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	3359229	3359229	+	C	C	T	Missense_Mutation	SNP	ENST00000635120.2	exon21	c.G3227A	p.R1076H	exonic	ENSG00000183117.19	.	nonsynonymous SNV	ENSG00000183117.19:ENST00000635120.2:exon21:c.G3227A:p.R1076H	8p23.2	C3L-00819	1.651e-05	9.762e-05	0	0	0	1.5e-05	0	0	rs748686121	13.19	D	D	D	D	D	D	.	T	D	0.942	T	T	D	0.556	.	0.655	.	T	T	D	T	D	D	3.786	25.800	0.999	D	D	0.628	6.222	0.568	5.841	1.000	0.487	0.574	0.574	0.564	.	5.240	5.240	7.699	1.000	0.597	1.000	0.063	0.007	964	Sushi/SCR/CCP_domain	.	.	ID=COSV59302829;OCCURENCE=1(liver),1(oesophagus),1(large_intestine),1(kidney)	CSMD1	177	0	359	48	0.117936117936118	TRUE	TRUE
ENSG00000164743.5	.	BCM	GRCh38.p13	chr8	13567179	13567179	+	G	G	T	Missense_Mutation	SNP	ENST00000297324.5	exon1	c.G188T	p.S63I	exonic	ENSG00000164743.5	.	nonsynonymous SNV	ENSG00000164743.5:ENST00000297324.5:exon1:c.G188T:p.S63I	8p22	C3L-00819	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	L	T	D	0.058	T	T	T	0.044	0.159	0.107	.	.	T	T	T	T	T	0.460	6.081	0.730	N	N	-1.250	0.194	-1.314	0.200	0.998	0.455	0.574	0.607	0.665	.	5.220	-1.880	-0.088	-0.566	-0.797	0.000	0.000	0.012	974	.	.	.	.	C8orf48	197	1	242	40	0.141843971631206	TRUE	TRUE
ENSG00000156345.17	.	BCM	GRCh38.p13	chr9	87974385	87974385	+	G	G	C	Missense_Mutation	SNP	ENST00000325303.8	exon1	c.C62G	p.A21G	exonic	ENSG00000156345.17	.	nonsynonymous SNV	ENSG00000156345.17:ENST00000325303.8:exon1:c.C62G:p.A21G	9q22.1	C3L-00819	.	.	.	.	.	.	.	.	.	7.20	T	T	P	P	D	D	L	T	D	0.677	T	T	T	0.261	0.937	0.460	0.126	T	T	T	T	D	D	3.410	24.400	0.988	D	D	0.332	3.948	0.379	4.211	1.000	0.652	0.608	0.641	0.555	.	4.140	4.140	4.890	0.862	0.584	1.000	1.000	0.955	953	Protein_kinase_domain;Protein_kinase,_ATP_binding_site	.	.	.	CDK20	113	0	300	30	0.0909090909090909	TRUE	TRUE
ENSG00000136830.12	.	BCM	GRCh38.p13	chr9	127508173	127508173	+	G	G	A	Missense_Mutation	SNP	ENST00000373312.4	exon12	c.C1462T	p.R488W	exonic	ENSG00000136830.12	.	nonsynonymous SNV	ENSG00000136830.12:ENST00000373312.4:exon12:c.C1462T:p.R488W	9q34.11	C3L-00819	1.663e-05	0	0	0	0	3.029e-05	0	0	rs772145640	17.20	D	D	D	D	D	D	M	T	D	0.930	T	T	D	0.439	0.598	0.334	0.963	D	D	D	D	D	D	4.134	28.000	0.999	D	D	0.592	5.843	0.531	5.455	1.000	0.707	0.588	0.723	0.714	.	4.930	3.970	1.272	1.101	0.590	1.000	0.976	0.866	523	.	.	.	ID=COSV55941898;OCCURENCE=1(central_nervous_system),1(haematopoietic_and_lymphoid_tissue)	NIBAN2	183	0	458	102	0.182142857142857	TRUE	TRUE
ENSG00000150275.18	.	BCM	GRCh38.p13	chr10	54195807	54195807	+	T	T	A	Missense_Mutation	SNP	ENST00000320301.10	exon11	c.A1181T	p.Y394F	exonic	ENSG00000150275.18	.	nonsynonymous SNV	ENSG00000150275.18:ENST00000320301.10:exon11:c.A1181T:p.Y394F	10q21.1	C3L-00819	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	.	D	L	T	N	0.656	T	T	T	0.221	0.306	0.733	0.198	T	T	T	T	D	D	3.037	23.500	0.981	D	D	0.567	5.602	0.551	5.654	0.995	0.487	0.574	0.574	0.564	.	5.170	5.170	7.986	1.118	0.609	1.000	0.994	0.890	937	Cadherin-like	.	.	.	PCDH15	340	0	291	46	0.136498516320475	TRUE	TRUE
ENSG00000122852.15	.	BCM	GRCh38.p13	chr10	79611949	79611949	+	C	C	T	Missense_Mutation	SNP	ENST00000398636.8	exon3	c.C124T	p.P42S	exonic	ENSG00000122852.15	.	nonsynonymous SNV	ENSG00000122852.15:ENST00000398636.8:exon3:c.C124T:p.P42S	10q22.3	C3L-00819	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	M	T	D	0.385	T	T	T	0.212	0.671	0.585	0.136	T	T	T	T	D	D	2.336	21.800	0.999	N	N	0.396	4.322	0.224	3.302	0.001	0.447	0.563	0.547	0.646	.	2.630	2.630	1.004	0.917	0.519	0.216	0.541	0.132	702	.	.	.	.	SFTPA1	150	0	520	81	0.13477537437604	NA	TRUE
ENSG00000132746.15	.	BCM	GRCh38.p13	chr11	67665542	67665542	+	C	C	T	Missense_Mutation	SNP	ENST00000673966.1	exon7	c.G449A	p.R150H	exonic	ENSG00000132746.15	.	nonsynonymous SNV	ENSG00000132746.15:ENST00000673966.1:exon7:c.G449A:p.R150H	11q13.2	C3L-00819	0.0002	0.0010	0	0.0001	0.0002	9e-05	0	6.058e-05	rs150455483	13.20	D	D	D	D	U	D	H	T	D	0.806	D	D	D	0.649	.	0.867	0.860	T	T	T	D	T	D	3.089	23.600	0.997	D	N	0.288	3.719	0.110	2.777	1.000	0.526	0.616	0.600	0.584	.	4.060	2.130	4.734	0.125	-0.179	1.000	0.807	0.804	774	Aldehyde_dehydrogenase_domain	.	.	ID=COSV62429131;OCCURENCE=3(large_intestine)	ALDH3B2	225	0	642	104	0.13941018766756	NA	TRUE
ENSG00000149311.18	.	BCM	GRCh38.p13	chr11	108289655	108289655	+	T	T	-	Frame_Shift_Del	DEL	ENST00000278616.8	exon29	c.4290delT	p.N1430Kfs*21	exonic	ENSG00000149311.18	.	frameshift deletion	ENSG00000149311.18:ENST00000278616.8:exon29:c.4290delT:p.N1430Kfs*21	11q22.3	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATM	85	0	50	5	0.0909090909090909	TRUE	TRUE
ENSG00000259571.2	.	BCM	GRCh38.p13	chr11	122115881	122115881	+	G	G	T	Missense_Mutation	SNP	ENST00000560104.2	exon1	c.C42A	p.F14L	exonic	ENSG00000259571.2	.	nonsynonymous SNV	ENSG00000259571.2:ENST00000560104.2:exon1:c.C42A:p.F14L	11q24.1	C3L-00819	1.66e-05	0	0	0.0001	0	1.51e-05	0	0	rs749390802	1.17	.	.	B	B	.	N	N	T	D	0.209	T	T	T	0.031	0.343	0.836	0.055	T	T	T	T	T	T	1.176	13.450	0.911	N	N	-0.794	0.664	-0.832	0.713	1.000	0.578	0.616	0.600	0.742	.	4.780	1.830	-0.040	0.120	0.618	0.000	0.025	0.039	921	.	.	.	.	BLID	81	0	130	24	0.155844155844156	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-00819	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	267	0	226	32	0.124031007751938	TRUE	TRUE
ENSG00000123352.18	.	BCM	GRCh38.p13	chr12	49522790	49522790	+	C	C	T	Nonsense_Mutation	SNP	ENST00000552918.6	exon12	c.C1048T	p.R350X	exonic	ENSG00000123352.18	.	stopgain	ENSG00000123352.18:ENST00000552918.6:exon12:c.C1048T:p.R350X	12q13.12	C3L-00819	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	D	A	.	.	.	0.510	.	.	.	.	.	.	.	.	.	D	D	.	.	5.760	34	0.998	N	N	0.346	4.027	0.137	2.892	0.020	0.732	0.725	0.744	0.714	.	5.840	2.870	0.050	0.072	0.599	0.045	0.992	0.986	170	.	.	.	.	SPATS2	168	0	176	14	0.0736842105263158	TRUE	NA
ENSG00000102554.14	.	BCM	GRCh38.p13	chr13	73062216	73062216	+	T	T	-	Frame_Shift_Del	DEL	ENST00000377687.6	exon2	c.617delT	p.F207Sfs*26	exonic	ENSG00000102554.14	.	frameshift deletion	ENSG00000102554.14:ENST00000377687.6:exon2:c.617delT:p.F207Sfs*26	13q22.1	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KLF5	214	0	384	54	0.123287671232877	TRUE	TRUE
ENSG00000137807.15	.	BCM	GRCh38.p13	chr15	69422368	69422368	+	G	G	A	Missense_Mutation	SNP	ENST00000260363.9	exon6	c.G496A	p.E166K	exonic	ENSG00000137807.15	.	nonsynonymous SNV	ENSG00000137807.15:ENST00000260363.9:exon6:c.G496A:p.E166K	15q23	C3L-00819	.	.	.	.	.	.	.	.	rs924358072	14.20	D	D	D	P	D	D	M	T	D	0.600	T	T	D	0.561	.	0.821	0.891	T	D	D	D	D	D	4.043	27.300	0.998	D	N	0.154	3.106	0.089	2.691	1.000	0.707	0.725	0.725	0.714	.	5.120	4.210	3.968	1.176	0.618	1.000	1.000	0.998	848	Kinesin_motor_domain	.	.	.	KIF23	100	0	92	12	0.115384615384615	TRUE	NA
ENSG00000225614.4	.	BCM	GRCh38.p13	chr16	88435079	88435079	+	G	G	A	Missense_Mutation	SNP	ENST00000565624.3	exon3	c.G7609A	p.E2537K	exonic	ENSG00000225614.4	.	nonsynonymous SNV	ENSG00000225614.4:ENST00000565624.3:exon3:c.G7609A:p.E2537K	16q24.2	C3L-00819	.	.	.	.	.	.	.	.	.	3.16	T	T	.	.	.	N	.	T	N	0.196	T	T	D	0.062	0.176	0.126	.	T	T	T	T	D	T	2.232	21.100	0.992	D	N	-0.242	1.761	-0.305	1.554	0.846	0.701	0.588	0.717	0.655	.	4.410	3.430	2.439	1.075	0.618	0.903	0.036	0.130	.	.	.	.	.	ZNF469	299	0	807	126	0.135048231511254	TRUE	TRUE
ENSG00000074755.15	.	BCM	GRCh38.p13	chr17	4025004	4025004	+	C	C	G	Missense_Mutation	SNP	ENST00000381638.7	exon43	c.G7007C	p.S2336T	exonic	ENSG00000074755.15	.	nonsynonymous SNV	ENSG00000074755.15:ENST00000381638.7:exon43:c.G7007C:p.S2336T	17p13.2	C3L-00819	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.157	T	T	T	0.079	0.096	0.043	0.136	T	T	T	T	T	T	1.469	15.540	0.208	N	N	-0.691	0.829	-0.427	1.325	0.001	0.707	0.725	0.725	0.714	.	5.800	2.590	2.902	0.215	-0.121	1.000	0.999	0.997	220	.	.	.	.	ZZEF1	573	0	911	134	0.12822966507177	TRUE	TRUE
ENSG00000198844.12	.	BCM	GRCh38.p13	chr17	8319552	8319552	+	C	C	T	Missense_Mutation	SNP	ENST00000361926.8	exon15	c.C2323T	p.R775W	exonic	ENSG00000198844.12	.	nonsynonymous SNV	ENSG00000198844.12:ENST00000361926.8:exon15:c.C2323T:p.R775W	17p13.1	C3L-00819	0.0249	0.0183	0.0156	0.0001	0.0101	0.0283	0.0235	0.0423	rs79993581	4.18	D	D	D	B	N	N	.	T	N	0.146	T	T	.	0.133	.	.	0.171	T	T	T	T	T	T	2.251	21.200	0.997	D	N	-0.055	2.322	-0.006	2.339	0.146	0.707	0.590	0.602	0.714	.	5.480	4.480	1.921	0.126	0.599	0.940	0.344	0.472	641	.	KRBA2;NLGN2	Colon_Sigmoid;Muscle_Skeletal	.	ARHGEF15	95	0	176	22	0.111111111111111	TRUE	NA
ENSG00000109046.15	.	BCM	GRCh38.p13	chr17	27311616	27311616	+	G	G	A	Missense_Mutation	SNP	ENST00000262394.7	exon8	c.G1106A	p.G369E	exonic	ENSG00000109046.15	.	nonsynonymous SNV	ENSG00000109046.15:ENST00000262394.7:exon8:c.G1106A:p.G369E	17q11.1	C3L-00819	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.992	D	D	D	0.851	0.835	0.397	0.615	D	T	D	D	D	T	5.833	35	0.998	D	D	1.028	14.813	0.927	14.958	1.000	0.707	0.725	0.725	0.711	.	5.010	5.010	9.832	1.176	0.676	1.000	1.000	0.994	119	WD40-repeat-containing_domain	.	.	.	WSB1	115	0	148	26	0.149425287356322	TRUE	TRUE
ENSG00000167131.17	.	BCM	GRCh38.p13	chr17	44902637	44902642	+	GAGCCG	GAGCCG	-	In_Frame_Del	DEL	ENST00000417826.3	exon4	c.549_554del	p.S184_R185del	exonic	ENSG00000167131.17	.	nonframeshift deletion	ENSG00000167131.17:ENST00000417826.3:exon4:c.549_554del:p.S184_R185del	17q21.31	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC103	510	0	1311	110	0.0774102744546094	TRUE	TRUE
ENSG00000118271.11	.	BCM	GRCh38.p13	chr18	31598599	31598599	+	G	G	A	Missense_Mutation	SNP	ENST00000237014.8	exon4	c.G368A	p.R123H	exonic	ENSG00000118271.11	.	nonsynonymous SNV	ENSG00000118271.11:ENST00000237014.8:exon4:c.G368A:p.R123H	18q12.1	C3L-00819	4.121e-05	0.0004	0	0	0	0	0	6.058e-05	rs148538950	14.20	D	D	P	B	D	D	M	D	N	0.786	D	D	D	0.566	.	0.996	0.932	T	D	T	D	T	D	3.542	24.800	0.991	D	D	0.446	4.642	0.391	4.298	1.000	0.487	0.547	0.547	0.564	.	5.980	5.980	7.679	1.176	0.618	1.000	0.047	0.016	705	Transthyretin/hydroxyisourate_hydrolase_domain	.	.	ID=COSV52701523;OCCURENCE=1(large_intestine)	TTR	709	0	1732	230	0.117227319062181	TRUE	TRUE
ENSG00000130300.9	.	BCM	GRCh38.p13	chr19	17365834	17365834	+	G	G	A	Missense_Mutation	SNP	ENST00000252590.9	exon3	c.C631T	p.R211C	exonic	ENSG00000130300.9	.	nonsynonymous SNV	ENSG00000130300.9:ENST00000252590.9:exon3:c.C631T:p.R211C	19p13.11	C3L-00819	8.244e-06	0	0	0	0	1.5e-05	0	0	rs772839272	5.19	D	D	D	P	N	N	L	.	D	0.423	T	T	T	0.090	0.525	0.220	1.015	T	T	T	T	D	T	2.747	22.900	0.997	N	N	-0.489	1.198	-0.693	0.910	0.016	0.615	0.588	0.573	0.655	.	5.040	-1.990	0.291	1.146	0.618	0.000	0.008	0.148	769	.	.	.	ID=COSV53087213;OCCURENCE=1(prostate),1(lung)	PLVAP	276	0	721	101	0.12287104622871	TRUE	TRUE
ENSG00000167642.13	.	BCM	GRCh38.p13	chr19	38290154	38290154	+	C	C	T	Missense_Mutation	SNP	ENST00000301244.12	exon5	c.C427T	p.R143C	exonic	ENSG00000167642.13;ENSG00000267748.4	.	nonsynonymous SNV	ENSG00000167642.13:ENST00000301244.12:exon5:c.C427T:p.R143C	19q13.2	C3L-00819	8.24e-06	0	0	0	0	0	0	6.058e-05	rs755052415	17.20	D	D	D	D	D	D	M	T	D	0.659	D	D	D	0.499	0.661	0.865	1.381	T	T	D	D	D	D	3.891	26.300	0.999	D	D	0.780	8.399	0.634	6.675	1.000	0.706	0.710	0.725	0.655	.	5.550	5.550	2.078	1.026	0.599	1.000	0.705	0.163	617	Pancreatic_trypsin_inhibitor_Kunitz_domain	.	.	.	SPINT2	361	0	1035	161	0.134615384615385	TRUE	NA
ENSG00000196263.8	.	BCM	GRCh38.p13	chr19	56525320	56525320	+	G	G	A	Missense_Mutation	SNP	ENST00000308031.10	exon5	c.G1253A	p.R418H	exonic	ENSG00000196263.8	.	nonsynonymous SNV	ENSG00000196263.8:ENST00000308031.10:exon5:c.G1253A:p.R418H	19q13.43	C3L-00819	4.12e-05	0	0	0	0.0002	2.997e-05	0.0011	6.059e-05	rs578040016	4.19	D	D	B	B	.	D	L	T	N	0.103	T	T	T	0.112	.	0.641	0.514	T	T	T	T	T	T	2.590	22.600	0.992	N	D	-0.317	1.574	-0.320	1.524	0.236	0.554	0.574	0.602	0.564	.	3.580	2.520	1.921	-0.386	-0.154	0.011	0.996	0.997	988	Zinc_finger_C2H2-type	.	.	.	ZNF471	222	0	202	35	0.147679324894515	TRUE	NA
ENSG00000124212.6	.	BCM	GRCh38.p13	chr20	49514320	49514320	+	C	C	T	Missense_Mutation	SNP	ENST00000244043.5	exon7	c.G931A	p.G311R	exonic	ENSG00000124212.6	.	nonsynonymous SNV	ENSG00000124212.6:ENST00000244043.5:exon7:c.G931A:p.G311R	20q13.13	C3L-00819	5.788e-05	0.0002	0	0.0002	0	0	0	0.0002	rs561823415	0.20	T	T	B	B	N	N	L	T	N	0.178	T	T	T	0.059	.	0.676	0.128	T	T	T	T	T	T	0.761	9.012	0.471	N	N	-0.737	0.752	-0.779	0.788	0.977	0.706	0.590	0.710	0.586	.	4.100	3.130	0.689	1.026	0.594	0.000	0.069	0.057	437	.	.	.	ID=COSV54840430;OCCURENCE=1(lung)	PTGIS	444	0	1038	143	0.12108382726503	TRUE	TRUE
ENSG00000185666.15	.	BCM	GRCh38.p13	chr22	32518188	32518188	+	G	G	A	Missense_Mutation	SNP	ENST00000358763.7	exon13	c.C1465T	p.R489W	exonic	ENSG00000185666.15	.	nonsynonymous SNV	ENSG00000185666.15:ENST00000358763.7:exon13:c.C1465T:p.R489W	22q12.3	C3L-00819	9.957e-05	0.0007	8.642e-05	0.0001	0	1.505e-05	0	0.0001	rs151051257	12.20	D	D	D	D	D	D	M	T	N	0.556	T	T	D	0.222	.	0.340	0.769	T	T	T	D	T	D	4.387	31	0.999	D	D	0.742	7.755	0.724	8.217	0.029	0.707	0.574	0.725	0.564	.	5.970	4.930	2.958	1.176	0.676	1.000	0.999	0.936	619	.	.	.	ID=COSV60504082;OCCURENCE=2(large_intestine)	SYN3	97	0	188	23	0.109004739336493	TRUE	TRUE
ENSG00000100399.16	.	BCM	GRCh38.p13	chr22	41238735	41238735	+	G	G	C	Missense_Mutation	SNP	ENST00000216241.14	exon3	c.C337G	p.L113V	exonic	ENSG00000100399.16	.	nonsynonymous SNV	ENSG00000100399.16:ENST00000216241.14:exon3:c.C337G:p.L113V	22q13.2	C3L-00819	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.165	T	T	T	0.041	0.345	0.283	0.027	T	T	T	T	T	T	1.466	15.520	0.836	N	N	-0.444	1.289	-0.246	1.679	1.000	0.403	0.547	0.587	0.563	.	4.900	2.490	2.122	1.176	0.676	1.000	0.998	1.000	158	.	.	.	.	CHADL	166	0	509	85	0.143097643097643	TRUE	TRUE
ENSG00000146950.13	.	BCM	GRCh38.p13	chrX	9898202	9898202	+	G	G	A	Missense_Mutation	SNP	ENST00000380913.8	exon5	c.G2803A	p.E935K	exonic	ENSG00000146950.13	.	nonsynonymous SNV	ENSG00000146950.13:ENST00000380913.8:exon5:c.G2803A:p.E935K	Xp22.2	C3L-00819	.	.	.	.	.	.	.	.	rs1002335210	5.19	D	T	D	B	N	N	L	T	N	0.239	T	T	D	0.090	0.290	0.296	0.366	T	T	T	T	D	T	2.284	21.500	0.984	D	.	.	.	.	.	1.000	.	.	.	.	.	4.630	3.770	4.771	0.154	0.676	0.774	0.029	0.511	937	.	.	.	.	SHROOM2	179	0	279	80	0.222841225626741	TRUE	NA
ENSG00000182798.10	.	BCM	GRCh38.p13	chrX	16170425	16170425	+	C	C	T	Missense_Mutation	SNP	ENST00000400004.6	exon2	c.C43T	p.R15C	exonic	ENSG00000182798.10	.	nonsynonymous SNV	ENSG00000182798.10:ENST00000400004.6:exon2:c.C43T:p.R15C	Xp22.2	C3L-00819	0	0	0	0	0	0	0	0	rs763866721	3.17	T	T	.	.	N	N	L	T	D	0.261	T	T	T	0.062	0.319	0.061	0.401	T	T	T	T	D	D	2.505	22.400	0.996	N	.	.	.	.	.	0.451	.	.	.	.	.	2.720	0.504	-0.092	-0.034	0.599	0.002	0.387	0.836	422	Melanoma_associated_antigen,_N-terminal	.	.	ID=COSV61556951;OCCURENCE=1(large_intestine)	MAGEB17	34	0	135	49	0.266304347826087	TRUE	TRUE
ENSG00000147050.15	.	BCM	GRCh38.p13	chrX	45079158	45079158	+	T	T	C	Missense_Mutation	SNP	ENST00000377967.8	exon20	c.T2951C	p.F984S	exonic	ENSG00000147050.15	.	nonsynonymous SNV	ENSG00000147050.15:ENST00000377967.8:exon20:c.T2951C:p.F984S	Xp11.3	C3L-00819	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	M	T	D	0.930	D	D	D	0.933	.	0.965	2.253	D	D	D	D	D	D	4.247	29.100	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.460	5.460	7.674	1.138	0.665	1.000	1.000	0.999	611	.	.	.	ID=COSV65043243;OCCURENCE=2(urinary_tract)	KDM6A	125	0	87	20	0.186915887850467	TRUE	TRUE
ENSG00000204410.16	.	BCM	GRCh38.p13	chr6	31740615	31740615	+	T	T	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000204410.16;ENSG00000255152.8	ENST00000375750.9:exon2:c.147+2T>G;ENST00000493662.6:exon2:c.147+2T>G	.	.	6p21.33	C3L-00819	.	.	.	.	.	.	.	.	.	3.3	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.456	32	0.975	D	.	0.858	10.019	0.664	7.126	1.000	0.020	0.074	0.036	0.105	0.744	4.640	3.500	1.593	0.135	0.587	0.976	0.011	0.547	889	.	.	.	.	MSH5	71	1	173	23	0.11734693877551	TRUE	TRUE
ENSG00000186094.17	.	BCM	GRCh38.p13	chr1	48539650	48539650	+	C	C	T	Silent	SNP	ENST00000371839.6	exon12	c.G1356A	p.P452P	exonic	ENSG00000186094.17	.	synonymous SNV	ENSG00000186094.17:ENST00000371839.6:exon12:c.G1356A:p.P452P	1p33	C3L-00819	.	.	.	.	.	.	.	.	rs927622923	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AGBL4	80	0	115	31	0.212328767123288	TRUE	NA
ENSG00000075391.16	.	BCM	GRCh38.p13	chr1	178458454	178458454	+	G	G	A	Silent	SNP	ENST00000462775.5	exon12	c.G2739A	p.Q913Q	exonic	ENSG00000075391.16	.	synonymous SNV	ENSG00000075391.16:ENST00000462775.5:exon12:c.G2739A:p.Q913Q	1q25.2	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RASAL2	153	0	571	55	0.0878594249201278	TRUE	TRUE
ENSG00000153820.13	.	BCM	GRCh38.p13	chr2	228017527	228017527	+	C	C	T	Silent	SNP	ENST00000392056.8	exon7	c.G3327A	p.P1109P	exonic	ENSG00000153820.13	.	synonymous SNV	ENSG00000153820.13:ENST00000392056.8:exon7:c.G3327A:p.P1109P	2q36.3	C3L-00819	8.461e-05	0	0	0.0011	0	0	0	6.203e-05	rs199683355	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPHKAP	90	0	252	31	0.109540636042403	TRUE	NA
ENSG00000173230.15	.	BCM	GRCh38.p13	chr3	121696773	121696773	+	G	G	A	Silent	SNP	ENST00000340645.9	exon13	c.C3735T	p.D1245D	exonic	ENSG00000173230.15	.	synonymous SNV	ENSG00000173230.15:ENST00000340645.9:exon13:c.C3735T:p.D1245D	3q13.33	C3L-00819	2.472e-05	0	0	0	0	2.997e-05	0	6.057e-05	rs759460081	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61464925;OCCURENCE=1(large_intestine),1(central_nervous_system),1(stomach),1(lung),1(thyroid)	GOLGB1	204	0	269	34	0.112211221122112	TRUE	TRUE
ENSG00000146005.4	.	BCM	GRCh38.p13	chr5	139817550	139817550	+	C	C	T	Silent	SNP	ENST00000274710.4	exon5	c.C1086T	p.D362D	exonic	ENSG00000146005.4	.	synonymous SNV	ENSG00000146005.4:ENST00000274710.4:exon5:c.C1086T:p.D362D	5q31.2	C3L-00819	4.943e-05	0	0	0	0	7.494e-05	0	6.056e-05	rs747518596	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51199034;OCCURENCE=1(breast),1(large_intestine)	PSD2	168	0	415	53	0.113247863247863	TRUE	TRUE
ENSG00000178409.13	.	BCM	GRCh38.p13	chr6	107069160	107069160	+	G	G	A	Silent	SNP	ENST00000429433.3	exon5	c.C2031T	p.P677P	exonic	ENSG00000178409.13	.	synonymous SNV	ENSG00000178409.13:ENST00000429433.3:exon5:c.C2031T:p.P677P	6q21	C3L-00819	1.714e-05	0	0	0.0001	0.0002	0	0	0	rs781978327	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BEND3	154	0	454	72	0.136882129277567	TRUE	NA
ENSG00000158941.16	.	BCM	GRCh38.p13	chr8	22619208	22619208	+	G	G	A	Silent	SNP	ENST00000308511.8	exon20	c.G2580A	p.E860E	exonic	ENSG00000158941.16	.	synonymous SNV	ENSG00000158941.16:ENST00000308511.8:exon20:c.G2580A:p.E860E	8p21.3	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCAR2	254	0	760	112	0.128440366972477	TRUE	NA
ENSG00000148704.13	.	BCM	GRCh38.p13	chr10	117137898	117137898	+	C	C	T	Silent	SNP	ENST00000369206.6	exon1	c.G159A	p.A53A	exonic	ENSG00000148704.13	.	synonymous SNV	ENSG00000148704.13:ENST00000369206.6:exon1:c.G159A:p.A53A	10q25.3	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VAX1	334	0	1092	128	0.104918032786885	TRUE	TRUE
ENSG00000174885.12	.	BCM	GRCh38.p13	chr11	281006	281006	+	C	C	G	Silent	SNP	ENST00000312165.5	exon4	c.C1272G	p.T424T	exonic	ENSG00000174885.12	.	synonymous SNV	ENSG00000174885.12:ENST00000312165.5:exon4:c.C1272G:p.T424T	11p15.5	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NLRP6	229	0	610	63	0.0936106983655275	TRUE	TRUE
ENSG00000174669.12	.	BCM	GRCh38.p13	chr11	66365945	66365945	+	G	G	A	Silent	SNP	ENST00000357440.7	exon10	c.C1050T	p.Y350Y	exonic	ENSG00000174669.12	.	synonymous SNV	ENSG00000174669.12:ENST00000357440.7:exon10:c.C1050T:p.Y350Y	11q13.2	C3L-00819	.	.	.	.	.	.	.	.	.	4.17	D	D	B	B	.	D	.	T	N	0.340	T	T	T	0.058	0.608	0.136	.	.	T	T	T	T	T	0.769	9.085	0.998	D	N	-0.199	1.879	-0.070	2.135	1.000	0.632	0.694	0.698	0.655	.	5.550	3.680	1.351	1.176	0.676	0.920	1.000	0.992	61	.	.	.	.	SLC29A2	487	0	892	117	0.11595639246779	TRUE	TRUE
ENSG00000205978.6	.	BCM	GRCh38.p13	chr14	24417020	24417020	+	G	G	A	Silent	SNP	ENST00000382554.4	exon9	c.G5271A	p.P1757P	exonic	ENSG00000205978.6	.	synonymous SNV	ENSG00000205978.6:ENST00000382554.4:exon9:c.G5271A:p.P1757P	14q12	C3L-00819	2.635e-05	0	0	0	0	3.105e-05	0	7.865e-05	rs368739121	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NYNRIN	38	0	130	17	0.115646258503401	TRUE	NA
ENSG00000172150.4	.	BCM	GRCh38.p13	chr17	3198127	3198127	+	C	C	T	Silent	SNP	ENST00000381951.1	exon1	c.C609T	p.V203V	exonic	ENSG00000172150.4	.	synonymous SNV	ENSG00000172150.4:ENST00000381951.1:exon1:c.C609T:p.V203V	17p13.3	C3L-00819	7.515e-05	0.0009	0	0	0	0	0	0	rs150553361	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67936059;OCCURENCE=1(central_nervous_system),1(skin),1(endometrium)	OR1A2	39	0	55	8	0.126984126984127	TRUE	TRUE
ENSG00000130477.15	.	BCM	GRCh38.p13	chr19	17633118	17633118	+	G	G	A	Silent	SNP	ENST00000519716.6	exon27	c.C3291T	p.Y1097Y	exonic	ENSG00000130477.15	.	synonymous SNV	ENSG00000130477.15:ENST00000519716.6:exon27:c.C3291T:p.Y1097Y	19p13.11	C3L-00819	0.0010	0.0106	0.0008	0	0	8.997e-05	0	0.0002	rs113090566	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99409595;OCCURENCE=1(breast)	UNC13A	115	0	185	26	0.123222748815166	TRUE	NA
ENSG00000186810.8	.	BCM	GRCh38.p13	chrX	71616488	71616488	+	C	C	T	Silent	SNP	ENST00000373693.4	exon2	c.G984A	p.R328R	exonic	ENSG00000186810.8	.	synonymous SNV	ENSG00000186810.8:ENST00000373693.4:exon2:c.G984A:p.R328R	Xq13.1	C3L-00819	1.215e-05	0	0	0	0	2.197e-05	0	0	rs747616337	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CXCR3	66	0	222	37	0.142857142857143	TRUE	NA
ENSG00000279804.2	.	BCM	GRCh38.p13	chr1	13234857	13234857	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000279804.2;ENSG00000250894.1	dist=8751;dist=11006	.	.	1p36.21	C3L-00819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRAMEF18	10	0	18	4	0.181818181818182	TRUE	NA
ENSG00000152763.17	.	BCM	GRCh38.p13	chr1	66925033	66925033	+	A	A	G	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000152763.17	dist=177	.	.	1p31.3	C3L-00819	.	.	.	.	.	.	.	.	.	7.15	D	D	.	.	.	D	.	T	N	0.361	T	T	D	0.058	0.117	0.227	1.887	D	.	T	T	D	T	3.509	24.700	0.990	D	N	-0.162	1.987	-0.025	2.277	1.000	0.267	0.484	0.520	0.562	.	3.880	3.880	1.313	1.117	0.647	1.000	1.000	0.998	831	.	.	.	.	WDR78	80	0	228	34	0.129770992366412	TRUE	TRUE
ENSG00000240707.3	.	BCM	GRCh38.p13	chr10	133081893	133081893	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000240707.3;ENSG00000256925.3	dist=105539;dist=1587	.	.	10q26.3	C3L-00819	0.0001	0	0	0	0	0.0003	0	0	rs756879823	0.12	.	.	B	B	.	.	.	.	.	0.106	T	T	T	0.101	0.071	0.043	.	T	.	T	T	T	T	0.004	1.359	0.499	N	N	-1.544	0.069	-1.698	0.052	0.001	0.057	0.063	0.074	0.063	.	0.891	-1.780	-1.636	-0.469	-1.013	0.000	0.000	0.000	981	.	.	.	.	LINC01168	239	0	676	119	0.149685534591195	TRUE	NA
ENSG00000152402.11	.	BCM	GRCh38.p13	chr11	106936684	106936684	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000152402.11	.	.	.	11q22.3	C3L-00819	.	.	.	.	.	.	.	.	.	2.14	T	T	.	.	.	N	.	D	N	0.074	T	T	D	0.137	0.570	0.570	.	.	.	T	T	T	T	-0.442	0.157	0.887	N	N	-1.169	0.249	-1.263	0.235	0.000	0.487	0.574	0.547	0.564	.	3.020	-0.256	-0.634	-0.848	-0.886	0.000	0.000	0.001	888	.	.	.	ID=COSV104388828;OCCURENCE=1(large_intestine)	GUCY1A2	141	0	172	29	0.144278606965174	TRUE	NA
ENSG00000261069.3	.	BCM	GRCh38.p13	chr15	25088363	25088363	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000261069.3	.	.	.	15q11.2	C3L-00819	.	.	.	.	.	.	.	.	rs944114015	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC124312.3	113	0	248	39	0.13588850174216	TRUE	NA
ENSG00000266887.1	.	BCM	GRCh38.p13	chr22	48850846	48850846	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000266887.1;ENSG00000205632.4	dist=70493;dist=15924	.	.	22q13.32	C3L-00819	0.0005	0	0	0	0	0	0	0.0011	rs374939649	1.11	D	T	.	.	.	.	.	.	N	.	T	T	.	0.016	0.176	0.014	.	.	.	T	T	T	T	-0.075	0.934	0.313	N	N	-1.063	0.341	-1.293	0.213	0.000	0.554	0.574	0.602	0.564	.	1.100	-0.400	-1.430	-2.058	-2.430	0.000	0.000	0.000	992	.	.	.	.	MIR4535	133	0	369	51	0.121428571428571	TRUE	NA
ENSG00000188886.3	.	BCM	GRCh38.p13	chr2	96135355	96135355	+	C	C	T	Missense_Mutation	SNP	ENST00000342380.2	exon3	c.G239A	p.R80Q	exonic	ENSG00000188886.3	.	nonsynonymous SNV	ENSG00000188886.3:ENST00000342380.2:exon3:c.G239A:p.R80Q	2q11.2	C3N-01714	8.351e-06	0	0	0	0	1.514e-05	0	0	rs373382016	2.20	T	T	D	P	N	N	L	T	N	0.309	T	T	D	0.158	.	0.727	0.218	T	T	T	T	T	T	2.487	22.400	0.988	N	N	0.041	2.659	-0.023	2.282	0.912	0.554	0.551	0.602	0.542	.	4.420	2.160	1.443	0.939	0.592	0.993	0.413	0.060	295	.	.	.	ID=COSV60903676;OCCURENCE=2(large_intestine)	ASTL	152	0	376	27	0.0669975186104218	TRUE	TRUE
ENSG00000168280.17	.	BCM	GRCh38.p13	chr2	148947022	148947022	+	A	A	G	Missense_Mutation	SNP	ENST00000435030.6	exon8	c.A713G	p.K238R	exonic	ENSG00000168280.17	.	nonsynonymous SNV	ENSG00000168280.17:ENST00000435030.6:exon8:c.A713G:p.K238R	2q23.1	C3N-01714	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	.	T	D	0.751	T	T	D	0.550	0.487	0.863	2.251	D	D	D	D	D	D	4.984	33	0.999	D	D	1.123	18.551	0.986	18.030	1.000	0.732	0.574	0.744	0.564	.	5.340	5.340	9.325	1.312	0.756	1.000	1.000	0.999	651	Kinesin_motor_domain	.	.	.	KIF5C	134	0	117	8	0.064	NA	TRUE
ENSG00000174279.4	.	BCM	GRCh38.p13	chr2	176080651	176080651	+	G	G	A	Missense_Mutation	SNP	ENST00000308618.4	exon3	c.C887T	p.A296V	exonic	ENSG00000174279.4	.	nonsynonymous SNV	ENSG00000174279.4:ENST00000308618.4:exon3:c.C887T:p.A296V	2q31.1	C3N-01714	2.388e-05	0	0	0	0	0	0	0.0001	rs765774536	11.20	D	T	P	B	D	D	L	D	N	0.505	T	T	D	0.459	0.406	0.822	.	D	T	D	D	D	T	3.178	23.800	0.996	D	D	-0.282	1.657	-0.247	1.677	1.000	0.598	0.590	0.607	0.639	.	4.040	3.140	7.495	1.087	0.525	1.000	0.359	0.529	694	.	.	.	ID=COSV57963877;OCCURENCE=1(oesophagus),2(thyroid)	EVX2	163	0	328	26	0.0734463276836158	TRUE	TRUE
ENSG00000196981.4	.	BCM	GRCh38.p13	chr3	122414679	122414679	+	G	G	A	Missense_Mutation	SNP	ENST00000330689.6	exon1	c.C850T	p.L284F	exonic	ENSG00000196981.4	.	nonsynonymous SNV	ENSG00000196981.4:ENST00000330689.6:exon1:c.C850T:p.L284F	3q21.1	C3N-01714	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	L	D	D	0.321	D	D	D	0.475	0.358	0.868	0.409	T	T	D	T	D	D	3.582	25.000	0.999	D	D	0.542	5.383	0.494	5.100	1.000	0.653	0.628	0.696	0.669	.	4.770	3.870	5.281	1.176	0.676	1.000	1.000	0.999	447	WD40_repeat,_conserved_site;WD40-repeat-containing_domain	.	.	.	WDR5B	414	0	569	37	0.0610561056105611	TRUE	TRUE
ENSG00000160145.15	.	BCM	GRCh38.p13	chr3	124268798	124268798	+	C	C	T	Missense_Mutation	SNP	ENST00000360013.7	exon5	c.C506T	p.T169M	exonic	ENSG00000160145.15	.	nonsynonymous SNV	ENSG00000160145.15:ENST00000360013.7:exon5:c.C506T:p.T169M	3q21.2	C3N-01714	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.794	T	T	D	0.533	0.419	0.718	1.694	T	D	D	D	D	D	3.651	25.200	0.999	D	D	0.990	13.607	0.921	14.702	1.000	0.554	0.547	0.618	0.568	.	5.460	5.460	7.905	1.026	0.599	1.000	0.918	0.876	688	CRAL-TRIO_lipid_binding_domain	.	.	.	KALRN	211	0	468	37	0.0732673267326733	TRUE	TRUE
ENSG00000109586.12	.	BCM	GRCh38.p13	chr4	173314170	173314170	+	G	G	A	Nonsense_Mutation	SNP	ENST00000265000.9	exon9	c.G1602A	p.W534X	exonic	ENSG00000109586.12	.	stopgain	ENSG00000109586.12:ENST00000265000.9:exon9:c.G1602A:p.W534X	4q34.1	C3N-01714	.	.	.	.	.	.	.	.	.	5.7	.	.	.	.	U	A	.	.	.	0.462	.	.	.	.	.	.	.	.	.	D	D	D	.	8.704	44	0.996	D	N	1.043	15.326	0.936	15.386	1.000	0.732	0.725	0.744	0.714	.	5.600	5.600	10.003	1.172	0.672	1.000	0.994	0.989	912	Ricin_B,_lectin_domain	.	.	.	GALNT7	157	0	196	23	0.105022831050228	TRUE	TRUE
ENSG00000204962.6	.	BCM	GRCh38.p13	chr5	140842811	140842811	+	G	G	A	Missense_Mutation	SNP	ENST00000531613.2	exon1	c.G1490A	p.R497Q	exonic	ENSG00000204962.6	.	nonsynonymous SNV	ENSG00000204962.6:ENST00000531613.2:exon1:c.G1490A:p.R497Q	5q31.3	C3N-01714	.	.	.	.	.	.	.	.	.	2.19	T	T	P	P	U	N	N	T	D	0.330	T	T	T	0.075	0.320	0.656	.	.	T	T	T	D	T	3.583	25.000	0.997	N	N	-0.204	1.866	-0.231	1.714	0.000	0.554	0.588	0.602	0.613	.	3.720	3.720	2.834	1.097	0.522	0.466	0.991	0.909	32	Cadherin-like	.	.	.	PCDHA8	719	0	1382	92	0.062415196743555	NA	TRUE
ENSG00000135298.14	.	BCM	GRCh38.p13	chr6	68956729	68956729	+	G	G	C	Missense_Mutation	SNP	ENST00000370598.6	exon8	c.G1445C	p.C482S	exonic	ENSG00000135298.14	.	nonsynonymous SNV	ENSG00000135298.14:ENST00000370598.6:exon8:c.G1445C:p.C482S	6q12	C3N-01714	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	.	T	D	0.984	D	D	D	0.727	0.868	0.554	0.895	T	T	D	D	D	D	3.659	25.200	0.990	D	D	0.971	13.021	0.795	9.963	1.000	0.554	0.574	0.602	0.564	.	5.190	5.190	9.564	1.176	0.676	1.000	0.306	0.020	913	.	.	.	ID=COSV101002291;OCCURENCE=1(stomach)	ADGRB3	252	0	491	37	0.0700757575757576	TRUE	TRUE
ENSG00000184486.10	.	BCM	GRCh38.p13	chr6	98836152	98836152	+	G	G	A	Missense_Mutation	SNP	ENST00000328345.8	exon1	c.G1279A	p.G427R	exonic	ENSG00000184486.10	.	nonsynonymous SNV	ENSG00000184486.10:ENST00000328345.8:exon1:c.G1279A:p.G427R	6q16.1	C3N-01714	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	U	D	L	D	D	0.661	D	D	D	0.485	0.266	0.892	.	T	T	D	T	D	T	4.474	32	0.998	D	D	0.626	6.194	0.612	6.382	1.000	0.598	0.563	0.378	0.639	.	4.510	4.510	6.564	1.171	0.676	1.000	1.000	1.000	882	.	.	.	ID=COSV60409574;OCCURENCE=1(skin)	POU3F2	142	0	327	34	0.0941828254847645	TRUE	TRUE
ENSG00000003147.19	.	BCM	GRCh38.p13	chr7	8218358	8218358	+	C	C	T	Missense_Mutation	SNP	ENST00000402384.8	exon6	c.G526A	p.V176M	exonic	ENSG00000003147.19	.	nonsynonymous SNV	ENSG00000003147.19:ENST00000402384.8:exon6:c.G526A:p.V176M	7p21.3	C3N-01714	0.0008	0	0	0	0	0.0014	0.0022	0.0002	rs148267518	17.20	D	D	D	D	D	D	M	T	D	0.749	D	D	D	0.395	.	0.875	0.606	D	D	T	D	T	D	3.844	26.000	0.999	D	D	0.846	9.758	0.842	11.474	1.000	0.732	0.588	0.744	0.714	.	6.000	6.000	7.905	1.026	0.599	1.000	0.927	0.991	951	Arfaptin_homology_(AH)_domain	.	.	.	ICA1	398	0	680	64	0.0860215053763441	TRUE	NA
ENSG00000126870.16	.	BCM	GRCh38.p13	chr7	158911615	158911615	+	A	A	C	Missense_Mutation	SNP	ENST00000407559.8	exon12	c.A1526C	p.D509A	exonic	ENSG00000126870.16	.	nonsynonymous SNV	ENSG00000126870.16:ENST00000407559.8:exon12:c.A1526C:p.D509A	7q36.3	C3N-01714	.	.	.	.	.	.	.	.	.	13.20	D	D	P	B	D	D	M	D	D	0.803	T	T	D	0.753	0.686	0.774	0.423	T	T	D	D	D	T	3.159	23.800	0.995	D	D	0.262	3.589	0.334	3.921	1.000	0.732	0.744	0.659	0.655	.	5.030	5.030	6.644	1.278	0.754	1.000	1.000	0.998	952	.	.	.	.	WDR60	117	0	160	14	0.0804597701149425	TRUE	TRUE
ENSG00000160957.14	.	BCM	GRCh38.p13	chr8	144513229	144513229	+	G	G	-	Frame_Shift_Del	NA	ENST00000617875.6	exon14	c.2452delC	p.L818Cfs*25	exonic	ENSG00000160957.14	.	frameshift deletion	ENSG00000160957.14:ENST00000617875.6:exon14:c.2452delC:p.L818Cfs*25	8q24.3	C3N-01714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RECQL4	75	0	196	23	0.105022831050228	NA	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971163	21971163	+	G	G	-	Frame_Shift_Del	NA	ENST00000304494.9	exon2	c.196delC	p.H66Tfs*80	exonic	ENSG00000147889.17	.	frameshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.196delC:p.H66Tfs*80	9p21.3	C3N-01714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	409	0	689	77	0.100522193211488	NA	TRUE
ENSG00000188133.6	.	BCM	GRCh38.p13	chr9	32784880	32784880	+	A	A	G	Missense_Mutation	SNP	ENST00000342743.6	exon2	c.A697G	p.T233A	exonic	ENSG00000188133.6	.	nonsynonymous SNV	ENSG00000188133.6:ENST00000342743.6:exon2:c.A697G:p.T233A	9p21.1	C3N-01714	.	.	.	.	.	.	.	.	.	9.19	T	T	D	D	D	D	N	.	N	0.444	T	T	T	0.133	0.140	0.048	0.904	T	T	D	D	D	T	3.158	23.800	0.989	D	D	0.496	5.008	0.527	5.410	1.000	0.549	0.563	0.590	0.530	.	5.570	5.570	5.052	1.312	0.756	1.000	0.998	0.932	637	.	.	.	.	TMEM215	89	0	150	29	0.162011173184358	TRUE	TRUE
ENSG00000148426.13	.	BCM	GRCh38.p13	chr10	11870309	11870309	+	C	C	T	Missense_Mutation	SNP	ENST00000277570.10	exon4	c.C1211T	p.P404L	exonic	ENSG00000148426.13	.	nonsynonymous SNV	ENSG00000148426.13:ENST00000277570.10:exon4:c.C1211T:p.P404L	10p14	C3N-01714	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	L	T	D	0.448	T	T	D	0.249	0.305	0.355	1.035	T	T	T	T	D	D	3.774	25.700	0.999	D	D	0.519	5.183	0.478	4.960	1.000	0.685	0.578	0.674	0.636	.	5.300	5.300	6.423	0.954	0.462	0.947	0.973	0.270	917	.	.	.	.	PROSER2	108	0	254	18	0.0661764705882353	TRUE	TRUE
ENSG00000138311.18	.	BCM	GRCh38.p13	chr10	62388416	62388416	+	A	A	G	Missense_Mutation	SNP	ENST00000395254.8	exon3	c.A764G	p.H255R	exonic	ENSG00000138311.18	.	nonsynonymous SNV	ENSG00000138311.18:ENST00000395254.8:exon3:c.A764G:p.H255R	10q21.2	C3N-01714	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	D	D	M	T	N	0.312	T	T	T	0.117	0.430	0.779	0.909	T	T	T	T	D	T	3.037	23.500	0.996	D	D	0.629	6.233	0.636	6.707	1.000	0.554	0.590	0.602	0.568	.	5.560	5.560	4.800	1.312	0.750	1.000	1.000	0.999	789	.	.	.	.	ZNF365	181	0	342	46	0.118556701030928	TRUE	TRUE
ENSG00000165660.8	.	BCM	GRCh38.p13	chr10	124826619	124826619	+	C	C	T	Missense_Mutation	SNP	ENST00000298492.6	exon5	c.C292T	p.R98W	exonic	ENSG00000165660.8	.	nonsynonymous SNV	ENSG00000165660.8:ENST00000298492.6:exon5:c.C292T:p.R98W	10q26.13	C3N-01714	.	.	.	.	.	.	.	.	rs968863430	16.19	D	D	D	D	D	D	.	T	D	0.991	T	T	D	0.599	0.747	0.618	1.053	D	D	D	D	D	D	4.070	27.500	0.999	D	D	0.573	5.662	0.520	5.345	0.983	0.707	0.725	0.725	0.714	.	5.820	3.780	2.045	1.000	0.581	1.000	0.998	0.991	741	MPN_domain	.	.	ID=COSV53716833;OCCURENCE=2(large_intestine)	ABRAXAS2	167	0	307	41	0.117816091954023	TRUE	TRUE
ENSG00000165970.12	.	BCM	GRCh38.p13	chr11	20617875	20617875	+	T	T	-	Frame_Shift_Del	NA	ENST00000525748.6	exon7	c.1251delT	p.S418Qfs*17	exonic	ENSG00000165970.12	.	frameshift deletion	ENSG00000165970.12:ENST00000525748.6:exon7:c.1251delT:p.S418Qfs*17	11p15.1	C3N-01714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC6A5	404	0	720	61	0.0781049935979513	NA	TRUE
ENSG00000052850.8	.	BCM	GRCh38.p13	chr11	44265153	44265153	+	C	C	T	Missense_Mutation	SNP	ENST00000652299.1	exon4	c.G937A	p.G313R	exonic	ENSG00000052850.8	.	nonsynonymous SNV	ENSG00000052850.8:ENST00000652299.1:exon4:c.G937A:p.G313R	11p11.2	C3N-01714	.	.	.	.	.	.	.	.	.	17.20	D	D	D	P	D	D	M	D	D	0.531	D	D	D	0.629	0.477	0.979	1.097	T	D	D	D	D	D	3.598	25.000	0.999	D	N	0.607	5.998	0.639	6.753	1.000	0.487	0.574	0.547	0.613	.	5.670	5.670	4.579	1.026	0.599	1.000	0.964	0.600	643	.	.	.	.	ALX4	59	0	162	15	0.0847457627118644	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-01714	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	286	1	471	67	0.12453531598513	TRUE	TRUE
ENSG00000179715.13	.	BCM	GRCh38.p13	chr12	47236235	47236235	+	G	G	A	Missense_Mutation	SNP	ENST00000546455.6	exon4	c.G1172A	p.R391Q	exonic	ENSG00000179715.13	.	nonsynonymous SNV	ENSG00000179715.13:ENST00000546455.6:exon4:c.G1172A:p.R391Q	12q13.11	C3N-01714	.	.	.	.	.	.	.	.	rs375607179	0.19	T	T	B	B	N	N	N	T	N	0.069	T	T	T	0.005	.	0.076	0.401	T	T	T	T	T	T	0.009	1.390	0.832	N	.	-1.659	0.043	-1.641	0.064	0.999	0.615	0.588	0.659	0.464	.	4.040	-2.930	-0.078	-0.444	-0.704	0.001	0.000	0.006	775	.	.	.	.	PCED1B	176	0	356	20	0.0531914893617021	TRUE	NA
ENSG00000188596.11	.	BCM	GRCh38.p13	chr12	96691278	96691278	+	C	C	T	Missense_Mutation	SNP	ENST00000524981.9	exon44	c.C6232T	p.R2078C	exonic	ENSG00000188596.11	.	nonsynonymous SNV	ENSG00000188596.11:ENST00000524981.9:exon44:c.C6232T:p.R2078C	12q23.1	C3N-01714	2.486e-05	9.636e-05	0	0	0	3.015e-05	0	0	rs375947114	2.15	T	T	.	.	N	N	.	.	D	0.351	T	T	T	0.173	.	0.402	0.045	.	T	T	T	D	T	2.866	23.100	0.936	N	N	-0.205	1.863	-0.144	1.927	0.001	0.651	0.574	0.574	0.684	.	5.630	4.730	0.962	1.024	0.599	0.693	0.938	0.641	505	.	.	.	.	CFAP54	156	0	217	22	0.0920502092050209	TRUE	NA
ENSG00000151952.16	.	BCM	GRCh38.p13	chr12	129074987	129074987	+	C	C	A	Missense_Mutation	SNP	ENST00000422113.7	exon9	c.G2188T	p.D730Y	exonic	ENSG00000151952.16	.	nonsynonymous SNV	ENSG00000151952.16:ENST00000422113.7:exon9:c.G2188T:p.D730Y	12q24.33	C3N-01714	.	.	.	.	.	.	.	.	.	11.20	D	D	D	P	D	D	M	T	D	0.698	T	T	D	0.264	0.595	0.256	0.973	T	T	T	T	D	D	3.544	24.800	0.995	D	N	0.502	5.053	0.406	4.402	0.466	0.615	0.588	0.659	0.564	.	4.300	4.300	2.832	1.000	0.599	1.000	0.993	0.905	994	Transmembrane_protein_family_132,_middle_domain	.	.	ID=COSV67159692;OCCURENCE=1(large_intestine)	TMEM132D	208	0	304	33	0.0979228486646884	TRUE	TRUE
ENSG00000133083.14	.	BCM	GRCh38.p13	chr13	35854557	35854557	+	C	C	T	Missense_Mutation	SNP	ENST00000360631.7	exon6	c.G977A	p.R326H	exonic	ENSG00000133083.14	.	nonsynonymous SNV	ENSG00000133083.14:ENST00000360631.7:exon6:c.G977A:p.R326H	13q13.3	C3N-01714	8.28e-06	0	0	0	0	1.503e-05	0	0	rs373217123	7.20	T	T	B	B	D	D	N	T	N	0.424	T	T	T	0.088	.	0.643	2.354	D	T	T	T	D	D	2.679	22.800	0.998	D	D	-0.012	2.469	0.204	3.203	1.000	0.507	0.574	0.658	0.621	.	5.670	5.670	4.789	1.026	0.599	1.000	0.998	0.998	655	.	.	.	ID=COSV55179916;OCCURENCE=1(large_intestine),2(stomach),1(endometrium)	DCLK1	89	0	130	12	0.0845070422535211	TRUE	TRUE
ENSG00000182253.15	.	BCM	GRCh38.p13	chr15	99130171	99130171	+	G	G	C	Missense_Mutation	SNP	ENST00000336292.11	exon4	c.G1811C	p.G604A	exonic	ENSG00000182253.15	.	nonsynonymous SNV	ENSG00000182253.15:ENST00000336292.11:exon4:c.G1811C:p.G604A	15q26.3	C3N-01714	.	.	.	.	.	.	.	.	.	0.16	T	T	.	.	.	N	.	T	N	0.152	T	T	T	0.033	0.150	0.081	0.174	T	T	T	T	T	T	0.008	1.386	0.535	N	N	-0.948	0.462	-0.995	0.495	1.000	0.615	0.542	0.659	0.563	.	5.870	-0.686	0.229	0.189	0.676	0.001	0.001	0.033	981	.	.	.	.	SYNM	382	0	766	60	0.0726392251815981	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7670685	7670685	+	G	G	A	Nonsense_Mutation	SNP	ENST00000269305.8	exon10	c.C1024T	p.R342X	exonic	ENSG00000141510.17	.	stopgain	ENSG00000141510.17:ENST00000269305.8:exon10:c.C1024T:p.R342X	17p13.1	C3N-01714	.	.	.	.	.	.	.	.	rs730882029	4.6	.	.	.	.	N	A	.	.	.	0.870	.	.	.	.	.	.	.	.	.	D	D	.	.	6.863	36	0.997	D	N	0.558	5.519	0.362	4.100	0.001	0.707	0.702	0.725	0.714	.	5.430	3.430	1.174	0.185	0.676	0.110	0.906	0.978	450	p53,_tetramerisation_domain	.	.	ID=COSV52665487;OCCURENCE=1(salivary_gland),57(breast),1(penis),1(peritoneum),8(liver),38(oesophagus),1(adrenal_gland),76(large_intestine),18(central_nervous_system),8(biliary_tract),1(pleura),2(vulva),11(ovary),11(NS),20(stomach),9(haematopoietic_and_lymphoid_tissue),6(urinary_tract),11(kidney),6(soft_tissue),27(pancreas),23(skin),4(prostate),20(lung),3(thyroid),25(upper_aerodigestive_tract),2(thymus),6(endometrium)	TP53	275	0	568	63	0.0998415213946117	TRUE	TRUE
ENSG00000154016.13	.	BCM	GRCh38.p13	chr17	19022074	19022074	+	C	C	T	Missense_Mutation	SNP	ENST00000284154.9	exon5	c.G539A	p.R180H	exonic	ENSG00000154016.13	.	nonsynonymous SNV	ENSG00000154016.13:ENST00000284154.9:exon5:c.G539A:p.R180H	17p11.2	C3N-01714	0.0003	0.0009	0.0012	0	0	0.0002	0.0024	0.0001	rs138402616	3.20	T	T	B	B	N	D	L	T	N	0.106	T	T	T	0.023	.	0.575	0.800	T	T	T	T	T	D	2.139	20.400	0.994	D	N	-0.410	1.361	-0.255	1.660	0.970	0.672	0.702	0.576	0.711	.	4.770	2.440	0.794	0.118	0.535	0.939	0.649	0.832	809	SH3_domain	.	.	.	GRAP	67	0	181	19	0.095	TRUE	NA
ENSG00000101049.17	.	BCM	GRCh38.p13	chr20	43569445	43569445	+	G	G	A	Missense_Mutation	SNP	ENST00000373100.7	exon6	c.G289A	p.V97M	exonic	ENSG00000101049.17	.	nonsynonymous SNV	ENSG00000101049.17:ENST00000373100.7:exon6:c.G289A:p.V97M	20q13.12	C3N-01714	4.953e-05	0	8.64e-05	0	0	4.508e-05	0	0.0001	rs149168513	14.20	D	D	D	D	D	D	M	T	D	0.892	T	T	D	0.566	.	0.768	0.850	T	T	T	D	D	D	4.208	28.700	0.999	D	D	0.848	9.783	0.775	9.421	1.000	0.554	0.588	0.547	0.542	.	4.240	4.240	9.968	1.146	0.676	1.000	0.996	0.935	730	Protein_kinase_domain	.	.	.	SGK2	184	0	396	32	0.0747663551401869	TRUE	NA
ENSG00000101144.13	.	BCM	GRCh38.p13	chr20	57228331	57228331	+	G	G	A	Missense_Mutation	SNP	ENST00000395863.8	exon2	c.C509T	p.T170M	exonic	ENSG00000101144.13	.	nonsynonymous SNV	ENSG00000101144.13:ENST00000395863.8:exon2:c.C509T:p.T170M	20q13.31	C3N-01714	8.237e-06	0	0	0	0	1.498e-05	0	0	rs371762840	18.20	D	D	D	D	D	D	M	T	D	0.937	D	D	D	0.725	.	0.887	1.739	T	D	D	D	D	D	3.991	26.900	0.999	D	D	0.861	10.093	0.820	10.742	1.000	0.648	0.590	0.693	0.564	.	5.630	5.630	9.103	1.176	0.676	1.000	0.465	0.552	783	TGF-beta,_propeptide	.	.	.	BMP7	391	0	722	70	0.0883838383838384	TRUE	NA
ENSG00000196576.15	.	BCM	GRCh38.p13	chr22	50280892	50280892	+	T	T	C	Missense_Mutation	SNP	ENST00000359337.9	exon24	c.A3845G	p.D1282G	exonic	ENSG00000196576.15	.	nonsynonymous SNV	ENSG00000196576.15:ENST00000359337.9:exon24:c.A3845G:p.D1282G	22q13.33	C3N-01714	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	N	D	M	T	D	0.816	T	T	D	0.315	0.789	0.531	2.106	T	T	T	T	D	D	4.238	29.000	0.998	D	D	0.495	5.001	0.441	4.662	1.000	0.672	0.702	0.723	0.711	.	4.380	4.380	6.038	1.066	0.580	1.000	0.999	0.991	616	Plexin,_cytoplasmic_RasGAP_domain	.	.	ID=COSV100833925;OCCURENCE=1(skin)	PLXNB2	388	0	897	97	0.0975855130784708	TRUE	TRUE
ENSG00000177189.14	.	BCM	GRCh38.p13	chrX	20164954	20164954	+	G	G	A	Missense_Mutation	SNP	ENST00000379565.9	exon18	c.C1709T	p.A570V	exonic	ENSG00000177189.14	.	nonsynonymous SNV	ENSG00000177189.14:ENST00000379565.9:exon18:c.C1709T:p.A570V	Xp22.12	C3N-01714	.	.	.	.	.	.	.	.	rs980055137	12.19	D	T	D	D	D	D	N	T	D	0.488	T	T	D	0.310	0.433	0.848	2.190	D	T	D	T	D	D	4.053	27.400	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.570	5.570	5.729	1.176	0.676	1.000	1.000	0.998	76	Protein_kinase_domain	.	.	.	RPS6KA3	253	0	288	58	0.167630057803468	TRUE	NA
ENSG00000189186.10	.	BCM	GRCh38.p13	chrX	27747826	27747826	+	A	A	G	Missense_Mutation	SNP	ENST00000451261.6	exon5	c.A931G	p.T311A	exonic	ENSG00000189186.10	.	nonsynonymous SNV	ENSG00000189186.10:ENST00000451261.6:exon5:c.A931G:p.T311A	Xp21.3	C3N-01714	.	.	.	.	.	.	.	.	.	3.11	.	T	.	.	.	D	M	T	.	0.179	.	.	T	.	.	0.043	0.787	T	T	T	T	.	T	1.647	16.680	0.459	D	.	.	.	.	.	0.151	.	.	.	.	.	3.660	1.120	4.275	1.312	0.756	1.000	0.015	0.155	854	WD40-repeat-containing_domain	.	.	.	DCAF8L2	251	0	426	29	0.0637362637362637	TRUE	TRUE
ENSG00000041515.16	.	BCM	GRCh38.p13	chr13	109019710	109019710	+	G	G	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000041515.16	ENST00000356711.7:exon23:c.2530-1G>T	.	.	13q33.3	C3N-01714	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.787	33	0.986	D	.	1.025	14.741	0.827	10.966	1.000	0.061	0.063	0.063	0.057	0.960	5.080	5.080	7.556	1.176	0.676	1.000	0.977	0.339	968	.	.	.	ID=COSV51803605;OCCURENCE=1(large_intestine)	MYO16	152	0	198	17	0.0790697674418605	TRUE	TRUE
ENSG00000205090.9	.	BCM	GRCh38.p13	chr1	1539761	1539761	+	C	C	T	Silent	SNP	ENST00000378733.9	exon2	c.G87A	p.A29A	exonic	ENSG00000205090.9	.	synonymous SNV	ENSG00000205090.9:ENST00000378733.9:exon2:c.G87A:p.A29A	1p36.33	C3N-01714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM240	218	1	404	27	0.0626450116009281	TRUE	NA
ENSG00000116852.14	.	BCM	GRCh38.p13	chr1	201000578	201000578	+	G	G	A	Silent	SNP	ENST00000422435.2	exon11	c.C1497T	p.N499N	exonic	ENSG00000116852.14	.	synonymous SNV	ENSG00000116852.14:ENST00000422435.2:exon11:c.C1497T:p.N499N	1q32.1	C3N-01714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIF21B	172	0	413	31	0.0698198198198198	TRUE	NA
ENSG00000163545.11	.	BCM	GRCh38.p13	chr1	205304350	205304350	+	G	G	A	Silent	SNP	ENST00000367157.6	exon7	c.C987T	p.R329R	exonic	ENSG00000163545.11	.	synonymous SNV	ENSG00000163545.11:ENST00000367157.6:exon7:c.C987T:p.R329R	1q32.1	C3N-01714	0.0001	0.0014	8.97e-05	0	0	1.604e-05	0	0	rs144977455	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NUAK2	80	0	212	23	0.0978723404255319	TRUE	NA
ENSG00000170549.4	.	BCM	GRCh38.p13	chr5	3599572	3599572	+	C	C	T	Silent	SNP	ENST00000302006.4	exon2	c.C624T	p.S208S	exonic	ENSG00000170549.4	.	synonymous SNV	ENSG00000170549.4:ENST00000302006.4:exon2:c.C624T:p.S208S	5p15.33	C3N-01714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57361038;OCCURENCE=1(endometrium)	IRX1	273	0	654	37	0.0535455861070912	TRUE	TRUE
ENSG00000164187.7	.	BCM	GRCh38.p13	chr5	36117738	36117738	+	G	G	A	Silent	SNP	ENST00000296603.5	exon10	c.C1299T	p.I433I	exonic	ENSG00000164187.7	.	synonymous SNV	ENSG00000164187.7:ENST00000296603.5:exon10:c.C1299T:p.I433I	5p13.2	C3N-01714	8.708e-06	0	8.831e-05	0	0	0	0	0	rs187816551	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56950263;OCCURENCE=2(skin)	LMBRD2	69	0	106	15	0.12396694214876	TRUE	TRUE
ENSG00000107560.12	.	BCM	GRCh38.p13	chr10	118040475	118040475	+	G	G	A	Silent	SNP	ENST00000355624.8	exon2	c.C444T	p.T148T	exonic	ENSG00000107560.12	.	synonymous SNV	ENSG00000107560.12:ENST00000355624.8:exon2:c.C444T:p.T148T	10q26.11	C3N-01714	1.656e-05	9.664e-05	0	0	0	0	0	6.072e-05	rs188765663	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62924859;OCCURENCE=3(oesophagus),1(large_intestine),1(upper_aerodigestive_tract),1(endometrium)	RAB11FIP2	188	0	222	16	0.0672268907563025	TRUE	TRUE
ENSG00000084110.11	.	BCM	GRCh38.p13	chr12	95976468	95976468	+	C	C	T	Silent	SNP	ENST00000261208.8	exon20	c.G1794A	p.P598P	exonic	ENSG00000084110.11	.	synonymous SNV	ENSG00000084110.11:ENST00000261208.8:exon20:c.G1794A:p.P598P	12q23.1	C3N-01714	6.598e-05	0	0	0.0005	0	4.497e-05	0.0011	0	rs149461774	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HAL	479	0	1009	106	0.095067264573991	TRUE	NA
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11854224	11854224	+	G	G	A	Silent	SNP	ENST00000262442.9	exon50	c.G9729A	p.P3243P	exonic	ENSG00000007174.18	.	synonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon50:c.G9729A:p.P3243P	17p12	C3N-01714	9.06e-05	9.61e-05	0.0008	0.0001	0	0	0	0	rs149731222	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH9	393	1	699	40	0.054127198917456	TRUE	NA
ENSG00000054523.17	.	BCM	GRCh38.p13	chr1	10303204	10303204	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000054523.17	.	.	.	1p36.22	C3N-01714	0.0005	0.0002	0.0006	0	0	0.0005	0.0011	0.0013	rs150181429	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55813876;OCCURENCE=1(bone)	KIF1B	217	0	321	25	0.0722543352601156	TRUE	TRUE
ENSG00000015153.14	.	BCM	GRCh38.p13	chr12	42238627	42238627	+	G	G	T	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000015153.14	dist=379	.	.	12q12	C3N-01714	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	YAF2	104	0	265	26	0.0893470790378007	TRUE	NA
ENSG00000140481.15	.	BCM	GRCh38.p13	chr15	74335146	74335146	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000140481.15	.	.	.	15q24.1	C3N-01714	.	.	.	.	.	.	.	.	.	1.16	D	T	B	B	.	N	.	T	N	0.136	T	T	T	0.035	.	0.124	.	.	.	T	T	T	T	0.273	3.977	0.872	N	N	-0.963	0.445	-1.048	0.432	0.595	0.497	0.590	0.547	0.542	.	3.920	-0.321	-0.074	-0.335	-1.054	0.000	0.001	0.002	799	.	.	.	.	CCDC33	187	0	307	44	0.125356125356125	TRUE	NA
ENSG00000088340.17	.	BCM	GRCh38.p13	chr20	35559187	35559187	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000088340.17	.	.	.	20q11.22	C3N-01714	.	.	.	.	.	.	.	.	rs937707491	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FER1L4	135	0	268	28	0.0945945945945946	TRUE	NA
ENSG00000196581.11	.	BCM	GRCh38.p13	chr1	4712037	4712037	+	C	C	T	Missense_Mutation	SNP	ENST00000378191.5	exon2	c.C167T	p.S56L	exonic	ENSG00000196581.11	.	nonsynonymous SNV	ENSG00000196581.11:ENST00000378191.5:exon2:c.C167T:p.S56L	1p36.32	C3L-02890	.	.	.	.	.	.	.	.	.	3.20	D	T	B	B	N	N	N	T	N	0.126	T	T	D	0.055	0.278	0.162	0.347	T	T	T	T	T	T	1.591	16.320	0.995	D	N	-0.689	0.831	-0.621	1.014	0.995	0.583	0.574	0.615	0.613	.	5.080	4.160	4.549	1.022	0.594	0.820	0.002	0.003	993	.	.	.	.	AJAP1	181	0	327	18	0.0521739130434783	TRUE	TRUE
ENSG00000116819.8	.	BCM	GRCh38.p13	chr1	35573960	35573960	+	G	G	A	Missense_Mutation	SNP	ENST00000373235.4	exon2	c.G61A	p.G21R	exonic	ENSG00000116819.8	.	nonsynonymous SNV	ENSG00000116819.8:ENST00000373235.4:exon2:c.G61A:p.G21R	1p34.3	C3L-02890	.	.	.	.	.	.	.	.	.	11.20	T	T	D	P	U	D	L	D	N	0.518	D	D	D	0.495	0.263	0.641	1.190	D	T	D	D	D	T	2.891	23.200	0.998	D	N	-0.101	2.171	-0.061	2.162	1.000	0.437	0.542	0.607	0.555	.	3.600	3.600	2.722	0.976	0.471	1.000	0.993	0.697	349	.	.	.	.	TFAP2E	162	0	241	31	0.113970588235294	TRUE	TRUE
ENSG00000116871.15	.	BCM	GRCh38.p13	chr1	36176553	36176553	+	C	C	T	Missense_Mutation	SNP	ENST00000373151.6	exon7	c.C1205T	p.P402L	exonic	ENSG00000116871.15	.	nonsynonymous SNV	ENSG00000116871.15:ENST00000373151.6:exon7:c.C1205T:p.P402L	1p34.3	C3L-02890	0.0004	0	0	0.0011	0	0.0004	0	0	rs780310575	1.20	T	T	B	B	N	N	N	T	N	0.060	T	T	D	0.019	0.182	0.043	0.229	T	T	T	T	T	T	0.249	3.693	0.953	N	N	-1.473	0.090	-1.502	0.107	1.000	0.789	0.702	0.768	0.714	.	5.510	-6.050	-0.039	-0.827	-0.319	0.000	0.000	0.417	156	.	.	.	ID=COSV60214922;OCCURENCE=1(large_intestine),2(stomach)	MAP7D1	52	0	67	5	0.0694444444444444	TRUE	TRUE
ENSG00000143390.17	.	BCM	GRCh38.p13	chr1	151342628	151342628	+	C	C	T	Missense_Mutation	SNP	ENST00000290524.8	exon11	c.G1409A	p.R470Q	exonic	ENSG00000143390.17	.	nonsynonymous SNV	ENSG00000143390.17:ENST00000290524.8:exon11:c.G1409A:p.R470Q	1q21.3	C3L-02890	0.0001	0	0	0	0	0.0003	0	0	rs138131380	9.20	D	D	D	D	D	D	L	T	N	0.418	T	T	T	0.152	.	0.652	0.664	T	T	T	T	T	D	3.882	26.200	1.000	D	D	0.689	6.963	0.680	7.396	1.000	0.707	0.696	0.702	0.714	.	5.420	5.420	2.662	1.026	0.549	1.000	1.000	0.999	310	RFX5,_C-terminal	.	.	.	RFX5	316	1	538	59	0.0988274706867672	TRUE	NA
ENSG00000027644.5	.	BCM	GRCh38.p13	chr1	156841054	156841054	+	G	G	C	Missense_Mutation	SNP	ENST00000368195.4	exon22	c.C3713G	p.S1238C	exonic	ENSG00000027644.5	.	nonsynonymous SNV	ENSG00000027644.5:ENST00000368195.4:exon22:c.C3713G:p.S1238C	1q23.1	C3L-02890	.	.	.	.	.	.	.	.	.	14.20	D	D	P	B	N	D	M	D	D	0.176	D	D	D	0.522	0.611	0.940	0.161	T	D	D	T	D	T	2.858	23.100	0.990	D	D	0.345	4.020	0.370	4.152	1.000	0.497	0.590	0.547	0.632	.	5.410	5.410	4.201	1.176	0.676	1.000	0.915	0.648	725	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	INSRR	415	0	703	46	0.061415220293725	TRUE	TRUE
ENSG00000198216.12	.	BCM	GRCh38.p13	chr1	181715352	181715352	+	G	G	A	Missense_Mutation	SNP	ENST00000367573.7	exon9	c.G1186A	p.A396T	exonic	ENSG00000198216.12	.	nonsynonymous SNV	ENSG00000198216.12:ENST00000367573.7:exon9:c.G1186A:p.A396T	1q25.3	C3L-02890	0	0	0	0	0	0	0	0	rs777265667	18.20	D	T	D	D	N	D	M	D	D	0.545	D	D	D	0.580	.	0.859	1.616	D	D	D	D	D	D	4.023	27.100	0.999	D	D	0.784	8.479	0.762	9.100	1.000	0.651	0.709	0.547	0.564	.	5.160	5.160	7.162	1.176	0.674	1.000	1.000	0.998	589	.	.	.	ID=COSV100704395;OCCURENCE=1(stomach)	CACNA1E	149	1	325	19	0.0552325581395349	TRUE	NA
ENSG00000066279.18	.	BCM	GRCh38.p13	chr1	197103616	197103616	+	T	T	C	Missense_Mutation	SNP	ENST00000367409.9	exon18	c.A5635G	p.I1879V	exonic	ENSG00000066279.18	.	nonsynonymous SNV	ENSG00000066279.18:ENST00000367409.9:exon18:c.A5635G:p.I1879V	1q31.3	C3L-02890	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.060	T	T	T	0.017	0.486	0.030	.	T	T	T	T	T	T	0.313	4.440	0.446	N	N	-1.397	0.118	-1.431	0.137	1.000	0.719	0.654	0.644	0.734	.	5.620	-3.200	-0.435	-0.151	-0.118	0.000	0.142	0.656	177	IQ_motif,_EF-hand_binding_site	.	.	.	ASPM	295	0	466	48	0.0933852140077821	TRUE	TRUE
ENSG00000175143.4	.	BCM	GRCh38.p13	chr1	248406047	248406047	+	G	G	A	Missense_Mutation	SNP	ENST00000366474.1	exon1	c.G53A	p.C18Y	exonic	ENSG00000175143.4	.	nonsynonymous SNV	ENSG00000175143.4:ENST00000366474.1:exon1:c.G53A:p.C18Y	1q44	C3L-02890	8.299e-06	9.903e-05	0	0	0	0	0	0	rs773073764	1.18	T	D	B	B	.	N	N	T	N	0.087	T	T	T	0.008	0.370	0.188	0.012	T	T	T	T	T	.	-0.386	0.206	0.251	N	N	-1.518	0.076	-1.541	0.093	0.000	0.487	0.547	0.574	0.564	.	3.080	-1.610	-0.676	-0.324	-0.123	0.000	0.003	0.043	982	.	.	.	.	OR2T1	95	0	188	13	0.0646766169154229	TRUE	TRUE
ENSG00000119771.15	.	BCM	GRCh38.p13	chr2	23706512	23706512	+	A	A	G	Missense_Mutation	SNP	ENST00000486442.6	exon14	c.A2476G	p.T826A	exonic	ENSG00000119771.15	.	nonsynonymous SNV	ENSG00000119771.15:ENST00000486442.6:exon14:c.A2476G:p.T826A	2p24.1	C3L-02890	.	.	.	.	.	.	.	.	.	10.18	T	D	.	.	D	D	L	T	N	0.665	T	T	D	0.466	.	0.454	.	D	T	D	T	D	D	2.620	22.700	0.982	D	D	-0.101	2.173	-0.014	2.312	1.000	0.672	0.702	0.597	0.636	.	5.190	5.190	9.241	1.311	0.756	1.000	0.840	0.714	916	.	.	.	.	KLHL29	132	0	228	19	0.0769230769230769	TRUE	TRUE
ENSG00000206559.8	.	BCM	GRCh38.p13	chr3	28413270	28413270	+	T	T	C	Missense_Mutation	SNP	ENST00000635992.1	exon2	c.T202C	p.Y68H	exonic	ENSG00000206559.8;ENSG00000283563.1	.	nonsynonymous SNV	ENSG00000283563.1:ENST00000635992.1:exon2:c.T202C:p.Y68H,ENSG00000206559.8:ENST00000383768.7:exon3:c.T202C:p.Y68H	3p24.1	C3L-02890	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	L	T	D	0.308	T	T	T	0.104	0.786	0.048	0.024	T	T	T	T	D	T	2.099	20.100	0.981	D	N	-0.015	2.457	0.089	2.690	0.000	0.638	0.588	0.574	0.668	.	5.410	4.040	1.485	1.138	0.665	0.979	0.313	0.979	639	Zinc_finger,_CW-type	.	.	.	ZCWPW2	222	0	367	21	0.0541237113402062	TRUE	TRUE
ENSG00000048342.16	.	BCM	GRCh38.p13	chr4	15502488	15502488	+	C	C	T	Missense_Mutation	SNP	ENST00000424120.5	exon5	c.C307T	p.R103C	exonic	ENSG00000048342.16	.	nonsynonymous SNV	ENSG00000048342.16:ENST00000424120.5:exon5:c.C307T:p.R103C	4p15.32	C3L-02890	.	.	.	.	.	.	.	.	rs367699902	14.20	D	D	D	D	D	D	M	T	D	0.719	T	T	D	0.165	0.303	0.545	0.339	T	D	T	T	D	D	3.987	26.900	0.999	D	D	0.719	7.386	0.684	7.466	0.999	0.706	0.574	0.710	0.655	.	5.560	4.640	3.991	1.026	0.599	1.000	0.999	0.957	656	.	.	.	ID=COSV67503463;OCCURENCE=1(stomach),1(upper_aerodigestive_tract),1(large_intestine)	CC2D2A	85	0	175	19	0.0979381443298969	TRUE	TRUE
ENSG00000170561.13	.	BCM	GRCh38.p13	chr5	2749672	2749672	+	G	G	A	Missense_Mutation	SNP	ENST00000302057.6	exon2	c.C365T	p.T122M	exonic	ENSG00000170561.13	.	nonsynonymous SNV	ENSG00000170561.13:ENST00000302057.6:exon2:c.C365T:p.T122M	5p15.33	C3L-02890	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.902	D	D	D	0.898	0.631	0.948	2.661	D	D	D	D	D	D	4.328	29.800	0.999	D	D	0.887	10.710	0.831	11.123	1.000	0.767	0.574	0.851	0.639	.	4.850	4.850	9.551	1.172	0.672	1.000	1.000	0.993	946	Homeobox_domain	.	.	.	IRX2	367	0	609	60	0.0896860986547085	TRUE	TRUE
ENSG00000175426.11	.	BCM	GRCh38.p13	chr5	96393045	96393045	+	G	G	A	Missense_Mutation	SNP	ENST00000311106.8	exon14	c.C2218T	p.R740W	exonic	ENSG00000175426.11	.	nonsynonymous SNV	ENSG00000175426.11:ENST00000311106.8:exon14:c.C2218T:p.R740W	5q15	C3L-02890	2.472e-05	0	0	0	0	0	0	0.0002	rs368253923	11.20	D	D	D	D	D	D	L	T	N	0.699	T	T	D	0.454	.	0.902	0.944	T	T	T	D	T	D	3.895	26.300	0.999	D	D	0.419	4.463	0.427	4.558	0.735	0.615	0.610	0.602	0.655	.	6.030	4.170	2.982	0.161	0.676	1.000	1.000	0.999	801	Prohormone_convertase_enzyme	.	.	.	PCSK1	220	1	367	43	0.104878048780488	TRUE	NA
ENSG00000272674.3	.	BCM	GRCh38.p13	chr5	141183415	141183415	+	G	G	A	Missense_Mutation	SNP	ENST00000609684.2	exon1	c.G856A	p.E286K	exonic	ENSG00000272674.3	.	nonsynonymous SNV	ENSG00000272674.3:ENST00000609684.2:exon1:c.G856A:p.E286K	5q31.3	C3L-02890	.	.	.	.	.	.	.	.	.	0.12	.	T	.	.	N	N	.	.	.	0.097	T	T	T	0.071	0.395	0.462	.	T	.	T	T	T	.	2.196	20.800	0.995	N	N	-0.442	1.293	-0.529	1.156	0.990	0.646	0.547	0.645	0.568	.	4.750	3.880	0.414	0.208	0.614	0.000	0.001	0.024	654	.	.	.	.	PCDHB16	207	0	370	32	0.0796019900497512	TRUE	TRUE
ENSG00000186439.14	.	BCM	GRCh38.p13	chr6	123548568	123548568	+	G	G	A	Missense_Mutation	SNP	ENST00000334268.9	exon3	c.C277T	p.R93C	exonic	ENSG00000186439.14	.	nonsynonymous SNV	ENSG00000186439.14:ENST00000334268.9:exon3:c.C277T:p.R93C	6q22.31	C3L-02890	0.0005	0.0042	0.0004	0	0	0	0	0.0001	rs370788759	3.20	D	D	P	B	N	N	N	T	N	0.237	T	T	T	0.073	.	0.340	.	T	T	T	T	T	T	3.061	23.500	0.996	D	N	-0.039	2.375	0.043	2.514	0.080	0.693	0.574	0.659	0.632	.	5.290	3.320	1.887	0.161	0.676	0.987	0.941	0.863	816	Aspartyl_beta-hydroxylase/Triadin_domain	.	.	ID=COSV100521887;OCCURENCE=1(large_intestine)	TRDN	107	0	197	13	0.0619047619047619	TRUE	NA
ENSG00000164694.17	.	BCM	GRCh38.p13	chr6	159233786	159233786	+	C	C	T	Missense_Mutation	SNP	ENST00000297267.14	exon11	c.C3274T	p.R1092W	exonic	ENSG00000164694.17	.	nonsynonymous SNV	ENSG00000164694.17:ENST00000297267.14:exon11:c.C3274T:p.R1092W	6q25.3	C3L-02890	.	.	.	.	.	.	.	.	.	5.20	D	D	D	P	N	N	N	T	D	0.424	T	T	T	0.041	0.288	0.441	0.167	T	T	T	T	D	T	2.733	22.900	0.993	N	N	-0.357	1.479	-0.534	1.148	1.000	0.623	0.563	0.378	0.563	.	4.360	2.260	0.170	-0.031	0.318	0.000	0.001	0.041	808	.	.	.	.	FNDC1	197	0	284	15	0.0501672240802676	TRUE	TRUE
ENSG00000164853.9	.	BCM	GRCh38.p13	chr7	1236130	1236130	+	C	C	T	Missense_Mutation	SNP	ENST00000316333.9	exon3	c.C749T	p.P250L	exonic	ENSG00000164853.9	.	nonsynonymous SNV	ENSG00000164853.9:ENST00000316333.9:exon3:c.C749T:p.P250L	7p22.3	C3L-02890	.	.	.	.	.	.	.	.	.	6.20	D	T	B	B	U	D	L	D	N	0.193	T	T	D	0.238	0.316	0.549	.	D	T	T	T	T	T	2.068	19.780	0.992	D	N	-0.223	1.812	-0.094	2.064	0.995	0.598	0.590	0.608	0.639	.	3.630	3.630	0.097	0.891	0.449	0.000	0.979	0.275	970	.	.	.	ID=COSV100310246;OCCURENCE=1(stomach)	UNCX	120	0	118	7	0.056	TRUE	TRUE
ENSG00000085563.15	.	BCM	GRCh38.p13	chr7	87515370	87515370	+	G	G	A	Missense_Mutation	SNP	ENST00000622132.5	exon25	c.C3143T	p.P1048L	exonic	ENSG00000085563.15	.	nonsynonymous SNV	ENSG00000085563.15:ENST00000622132.5:exon25:c.C3143T:p.P1048L	7q21.12	C3L-02890	2.474e-05	0	8.654e-05	0	0	3e-05	0	0	rs756736504	12.19	D	D	D	B	N	D	L	D	D	0.329	D	D	D	0.513	0.649	0.356	0.272	T	.	T	T	T	D	3.282	24.100	0.961	D	D	-0.153	2.012	-0.119	1.992	0.996	0.554	0.588	0.618	0.621	.	5.960	5.080	6.812	0.229	-0.104	1.000	0.098	0.458	485	ABC_transporter-like	.	.	ID=COSV55944903;OCCURENCE=1(skin),1(lung)	ABCB1	402	0	795	52	0.0613931523022432	TRUE	TRUE
ENSG00000106236.4	.	BCM	GRCh38.p13	chr7	98624972	98624972	+	C	C	T	Missense_Mutation	SNP	ENST00000265634.4	exon3	c.C694T	p.R232C	exonic	ENSG00000106236.4	.	nonsynonymous SNV	ENSG00000106236.4:ENST00000265634.4:exon3:c.C694T:p.R232C	7q22.1	C3L-02890	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.921	T	T	D	0.581	0.771	0.489	1.325	D	D	D	D	D	D	3.847	26.100	0.999	D	D	0.822	9.229	0.714	8.020	1.000	0.706	0.590	0.710	0.621	.	5.570	5.570	6.085	1.026	0.599	1.000	0.905	0.436	231	.	.	.	.	NPTX2	135	0	268	34	0.112582781456954	TRUE	NA
ENSG00000214300.7	.	BCM	GRCh38.p13	chr7	100317092	100317092	+	C	C	A	Missense_Mutation	SNP	ENST00000332397.6	exon8	c.C1283A	p.A428E	exonic	ENSG00000214300.7	.	nonsynonymous SNV	ENSG00000214300.7:ENST00000332397.6:exon8:c.C1283A:p.A428E	7q22.1	C3L-02890	.	.	.	.	.	.	.	.	.	4.16	T	T	.	.	D	N	M	.	D	0.585	T	T	T	0.073	0.480	0.043	2.504	.	T	T	T	D	T	1.222	13.810	0.634	N	N	-0.791	0.669	-1.013	0.473	0.000	0.615	0.634	0.659	0.568	.	0.418	-0.836	1.024	0.318	0.217	0.561	0.028	0.146	275	.	.	.	.	SPDYE3	454	0	696	77	0.0996119016817594	NA	TRUE
ENSG00000106331.17	.	BCM	GRCh38.p13	chr7	127613803	127613803	+	C	C	T	Missense_Mutation	SNP	ENST00000639438.3	exon7	c.G515A	p.R172Q	exonic	ENSG00000106331.17	.	nonsynonymous SNV	ENSG00000106331.17:ENST00000639438.3:exon7:c.G515A:p.R172Q	7q32.1	C3L-02890	4.119e-05	0	0	0.0001	0	2.997e-05	0	0.0001	rs587780414	17.19	D	D	D	D	D	D	.	D	D	0.764	D	D	D	0.871	.	0.968	0.353	T	T	D	D	D	D	4.131	28.000	1.000	D	D	0.767	8.167	0.727	8.300	1.000	0.487	0.574	0.547	0.542	.	5.320	5.320	5.233	1.026	0.599	1.000	0.993	0.924	0	Homeobox_domain	.	.	ID=COSV58392056;OCCURENCE=1(lung)	PAX4	298	0	514	50	0.0886524822695035	TRUE	NA
ENSG00000181790.11	.	BCM	GRCh38.p13	chr8	142464884	142464884	+	C	C	-	Frame_Shift_Del	NA	ENST00000517894.5	exon2	c.686delC	p.R231Afs*6	exonic	ENSG00000181790.11	.	frameshift deletion	ENSG00000181790.11:ENST00000517894.5:exon2:c.686delC:p.R231Afs*6	8q24.3	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADGRB1	190	0	311	45	0.126404494382022	TRUE	TRUE
ENSG00000178445.10	.	BCM	GRCh38.p13	chr9	6553427	6553427	+	C	C	T	Missense_Mutation	SNP	ENST00000321612.8	exon20	c.G2398A	p.V800I	exonic	ENSG00000178445.10	.	nonsynonymous SNV	ENSG00000178445.10:ENST00000321612.8:exon20:c.G2398A:p.V800I	9p24.1	C3L-02890	1.648e-05	0	0	0	0	1.499e-05	0	6.056e-05	rs754581403	6.20	T	T	B	B	N	D	L	D	N	0.166	D	D	D	0.270	0.546	0.755	0.041	T	T	T	T	T	D	0.327	4.603	0.855	N	N	-0.925	0.489	-0.920	0.593	1.000	0.706	0.702	0.710	0.375	.	4.840	-0.461	1.002	-0.239	-0.193	0.584	0.530	0.129	768	.	.	.	.	GLDC	376	0	651	72	0.0995850622406639	TRUE	NA
ENSG00000198642.7	.	BCM	GRCh38.p13	chr9	21333368	21333368	+	T	T	C	Missense_Mutation	SNP	ENST00000359039.5	exon1	c.A1492G	p.I498V	exonic	ENSG00000198642.7	.	nonsynonymous SNV	ENSG00000198642.7:ENST00000359039.5:exon1:c.A1492G:p.I498V	9p21.3	C3L-02890	.	.	.	.	.	.	.	.	.	6.20	D	T	P	P	U	D	L	D	N	0.418	T	T	T	0.450	0.651	0.579	0.613	T	T	T	T	D	T	3.058	23.500	0.993	D	D	0.281	3.684	0.361	4.092	1.000	0.722	0.663	0.663	0.735	.	4.950	4.950	7.979	1.120	0.644	1.000	1.000	0.996	740	.	.	.	.	KLHL9	562	0	926	75	0.0749250749250749	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971121	21971121	+	G	G	A	Nonsense_Mutation	SNP	ENST00000304494.9	exon2	c.C238T	p.R80X	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon2:c.C238T:p.R80X	9p21.3	C3L-02890	.	.	.	.	.	.	.	.	rs121913388	9.16	T	D	.	.	N	D	.	D	D	0.305	T	T	.	0.480	.	0.977	.	T	T	D	D	D	T	7.418	38	0.998	D	D	0.265	3.604	0.302	3.727	1.000	0.677	0.383	0.608	0.601	.	5.930	5.010	1.260	1.176	0.676	0.882	0.552	0.951	900	.	.	.	ID=COSV58682746;OCCURENCE=1(salivary_gland),2(breast),17(penis),1(liver),29(oesophagus),6(large_intestine),4(central_nervous_system),9(biliary_tract),11(vulva),5(ovary),2(bone),7(NS),3(stomach),19(haematopoietic_and_lymphoid_tissue),2(soft_tissue),2(kidney),6(urinary_tract),26(pancreas),49(skin),1(prostate),15(lung),7(thyroid),70(upper_aerodigestive_tract),2(thymus),1(small_intestine),3(endometrium)	CDKN2A	658	0	1016	223	0.17998385794996	TRUE	TRUE
ENSG00000183049.12	.	BCM	GRCh38.p13	chr10	12824469	12824469	+	G	G	A	Missense_Mutation	SNP	ENST00000619168.4	exon9	c.G838A	p.A280T	exonic	ENSG00000183049.12	.	nonsynonymous SNV	ENSG00000183049.12:ENST00000619168.4:exon9:c.G838A:p.A280T	10p13	C3L-02890	.	.	.	.	.	.	.	.	rs912179319	5.20	T	T	B	B	D	D	L	T	N	0.409	T	T	T	0.078	0.262	0.382	.	T	T	T	T	D	D	2.902	23.200	0.988	D	N	0.067	2.757	0.204	3.202	0.992	0.706	0.710	0.710	0.616	.	5.120	5.120	4.265	1.176	0.676	1.000	0.990	0.989	969	.	.	.	ID=COSV66609732;OCCURENCE=1(large_intestine)	CAMK1D	236	0	445	43	0.0881147540983607	TRUE	TRUE
ENSG00000149571.12	.	BCM	GRCh38.p13	chr11	126424903	126424903	+	C	C	T	Missense_Mutation	SNP	ENST00000525144.7	exon17	c.G2014A	p.G672S	exonic	ENSG00000149571.12	.	nonsynonymous SNV	ENSG00000149571.12:ENST00000525144.7:exon17:c.G2014A:p.G672S	11q24.2	C3L-02890	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	D	D	N	T	N	0.833	T	T	D	0.213	0.602	0.647	1.275	D	T	D	D	D	D	2.717	22.900	0.999	D	D	0.443	4.624	0.511	5.264	1.000	0.581	0.547	0.576	0.613	.	4.880	4.880	7.331	1.026	0.599	1.000	0.845	0.918	951	.	.	.	.	KIRREL3	117	0	189	13	0.0643564356435644	TRUE	TRUE
ENSG00000111713.3	.	BCM	GRCh38.p13	chr12	21575939	21575939	+	C	C	-	Frame_Shift_Del	NA	ENST00000261195.3	exon3	c.422delG	p.G141Afs*13	exonic	ENSG00000111713.3	.	frameshift deletion	ENSG00000111713.3:ENST00000261195.3:exon3:c.422delG:p.G141Afs*13	12p12.1	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GYS2	266	0	455	61	0.118217054263566	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-02890	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	269	0	590	85	0.125925925925926	TRUE	TRUE
ENSG00000174718.12	.	BCM	GRCh38.p13	chr12	31984167	31984167	+	C	C	T	Missense_Mutation	SNP	ENST00000312561.9	exon4	c.C3212T	p.T1071I	exonic	ENSG00000174718.12	.	nonsynonymous SNV	ENSG00000174718.12:ENST00000312561.9:exon4:c.C3212T:p.T1071I	12p11.21	C3L-02890	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.041	T	T	T	0.007	0.316	0.040	0.011	T	T	T	T	T	T	0.082	1.931	0.977	N	N	-1.038	0.365	-1.142	0.335	0.998	0.707	0.702	0.644	0.714	.	5.300	-1.320	-0.378	-0.388	-0.273	0.000	0.002	0.001	958	.	.	.	.	RESF1	60	0	104	17	0.140495867768595	TRUE	TRUE
ENSG00000137766.17	.	BCM	GRCh38.p13	chr15	54013186	54013186	+	C	C	T	Nonsense_Mutation	SNP	ENST00000260323.15	exon1	c.C283T	p.R95X	exonic	ENSG00000137766.17	.	stopgain	ENSG00000137766.17:ENST00000260323.15:exon1:c.C283T:p.R95X	15q21.3	C3L-02890	0.0001	0	0	0.0001	0.0009	9.034e-05	0	6.066e-05	rs777064285	4.5	.	.	.	.	.	A	.	.	.	0.275	.	.	.	.	.	.	.	.	.	D	D	.	.	5.958	35	0.997	D	N	0.511	5.121	0.328	3.883	0.000	0.487	0.574	0.574	0.564	.	5.090	1.930	1.615	0.947	0.599	1.000	1.000	0.992	844	.	.	.	ID=COSV52872525;OCCURENCE=1(upper_aerodigestive_tract)	UNC13C	197	0	362	22	0.0572916666666667	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675209	7675209	+	A	A	-	Frame_Shift_Del	NA	ENST00000269305.8	exon5	c.403delT	p.C135Afs*35	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon5:c.403delT:p.C135Afs*35	17p13.1	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	239	0	389	32	0.0760095011876485	TRUE	TRUE
ENSG00000008838.20	.	BCM	GRCh38.p13	chr17	40035249	40035249	+	G	G	A	Missense_Mutation	SNP	ENST00000394128.7	exon6	c.C427T	p.R143W	exonic	ENSG00000008838.20	.	nonsynonymous SNV	ENSG00000008838.20:ENST00000394128.7:exon6:c.C427T:p.R143W	17q21.1	C3L-02890	1.702e-05	0	0	0	0	3.104e-05	0	0	rs776181925	9.20	D	D	D	P	N	D	L	T	D	0.465	T	T	T	0.111	0.282	0.585	0.454	T	T	T	T	D	D	3.614	25.100	0.992	D	D	0.487	4.937	0.573	5.902	1.000	0.716	0.702	0.732	0.297	.	6.060	6.060	3.162	1.176	0.676	1.000	0.998	0.984	173	Mediator_complex,_subunit_Med24,_N-terminal	.	.	.	MED24	232	0	407	38	0.0853932584269663	TRUE	NA
ENSG00000006283.18	.	BCM	GRCh38.p13	chr17	50621703	50621703	+	T	T	G	Missense_Mutation	SNP	ENST00000359106.10	exon35	c.T5969G	p.I1990S	exonic	ENSG00000006283.18	.	nonsynonymous SNV	ENSG00000006283.18:ENST00000359106.10:exon35:c.T5969G:p.I1990S	17q21.33	C3L-02890	.	.	.	.	.	.	.	.	.	12.20	D	T	B	B	N	D	L	D	N	0.742	D	D	D	0.513	0.375	0.929	0.720	T	T	D	D	D	D	2.934	23.300	0.983	D	D	-0.001	2.508	0.146	2.932	1.000	0.455	0.547	0.607	0.563	.	4.840	4.840	5.505	1.138	0.665	1.000	1.000	0.998	855	.	.	.	.	CACNA1G	99	0	205	28	0.120171673819742	TRUE	TRUE
ENSG00000158201.10	.	BCM	GRCh38.p13	chr18	21683945	21683945	+	C	C	G	Missense_Mutation	SNP	ENST00000289119.7	exon4	c.G530C	p.R177T	exonic	ENSG00000158201.10	.	nonsynonymous SNV	ENSG00000158201.10:ENST00000289119.7:exon4:c.G530C:p.R177T	18q11.2	C3L-02890	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	H	T	D	0.904	D	D	D	0.884	0.905	0.944	0.906	T	T	D	D	D	D	3.803	25.800	0.984	D	N	0.811	8.994	0.711	7.969	1.000	0.615	0.634	0.659	0.655	.	4.660	4.660	3.712	1.011	0.531	1.000	1.000	0.998	759	Alpha/beta_hydrolase_fold-1	.	.	.	ABHD3	190	0	406	48	0.105726872246696	TRUE	TRUE
ENSG00000198795.11	.	BCM	GRCh38.p13	chr18	25224485	25224485	+	C	C	T	Missense_Mutation	SNP	ENST00000361524.8	exon4	c.G3433A	p.V1145I	exonic	ENSG00000198795.11	.	nonsynonymous SNV	ENSG00000198795.11:ENST00000361524.8:exon4:c.G3433A:p.V1145I	18q11.2	C3L-02890	8.241e-06	0	0	0	0	1.499e-05	0	0	rs770755347	9.20	T	T	D	D	D	D	M	T	N	0.666	T	T	T	0.252	0.695	0.043	0.282	T	T	T	T	D	D	3.590	25.000	0.973	D	D	0.807	8.916	0.827	10.984	1.000	0.672	0.547	0.688	0.711	.	5.980	5.980	7.563	1.026	0.599	1.000	0.986	0.987	908	Zinc_finger_C2H2-type	.	.	ID=COSV64124244;OCCURENCE=3(pancreas)	ZNF521	182	0	318	145	0.31317494600432	TRUE	TRUE
ENSG00000141639.12	.	BCM	GRCh38.p13	chr18	50664481	50664481	+	G	G	A	Missense_Mutation	SNP	ENST00000400384.7	exon2	c.G523A	p.V175I	exonic	ENSG00000141639.12	.	nonsynonymous SNV	ENSG00000141639.12:ENST00000400384.7:exon2:c.G523A:p.V175I	18q21.1	C3L-02890	6.22e-05	0	0	0	0	4.731e-05	0	0.0003	rs761132815	5.20	T	T	P	B	D	D	N	T	N	0.301	T	T	D	0.053	.	0.762	1.411	T	T	T	T	T	D	2.310	21.600	0.999	D	N	0.115	2.946	0.211	3.236	1.000	0.638	0.590	0.653	0.564	.	5.870	5.000	2.951	1.176	0.676	1.000	0.825	0.296	626	Protein_kinase_domain	.	.	ID=COSV101245301;OCCURENCE=1(stomach)	MAPK4	71	0	101	7	0.0648148148148148	TRUE	NA
ENSG00000129932.10	.	BCM	GRCh38.p13	chr19	3496745	3496745	+	G	G	A	Missense_Mutation	SNP	ENST00000427575.6	exon2	c.C70T	p.R24C	exonic	ENSG00000129932.10	.	nonsynonymous SNV	ENSG00000129932.10:ENST00000427575.6:exon2:c.C70T:p.R24C	19p13.3	C3L-02890	1.696e-05	0	0	0	0	3.1e-05	0	0	rs766745007	18.19	D	D	D	D	D	D	H	.	D	0.947	D	D	D	0.879	0.869	0.601	1.277	T	D	D	D	D	D	3.700	25.400	0.999	D	D	0.780	8.406	0.644	6.827	1.000	0.707	0.702	0.725	0.714	.	4.280	4.280	4.046	1.164	0.662	1.000	0.997	0.784	952	.	.	.	.	DOHH	257	0	450	27	0.0566037735849057	TRUE	NA
ENSG00000101187.16	.	BCM	GRCh38.p13	chr20	62656858	62656858	+	A	A	G	Missense_Mutation	SNP	ENST00000217159.6	exon2	c.A404G	p.Y135C	exonic	ENSG00000101187.16	.	nonsynonymous SNV	ENSG00000101187.16:ENST00000217159.6:exon2:c.A404G:p.Y135C	20q13.33	C3L-02890	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	N	D	M	T	D	0.343	T	T	D	0.230	0.919	0.705	0.867	T	T	T	T	D	D	2.164	20.600	0.986	D	N	-0.124	2.100	-0.335	1.494	1.000	0.672	0.702	0.723	0.655	.	4.580	-2.420	1.382	-0.168	-0.114	0.879	0.477	0.029	608	Major_facilitator_superfamily_domain	.	.	.	SLCO4A1	95	0	175	13	0.0691489361702128	TRUE	TRUE
ENSG00000160284.15	.	BCM	GRCh38.p13	chr21	46161497	46161497	+	G	G	A	Missense_Mutation	SNP	ENST00000291672.6	exon5	c.C905T	p.A302V	exonic	ENSG00000160284.15	.	nonsynonymous SNV	ENSG00000160284.15:ENST00000291672.6:exon5:c.C905T:p.A302V	21q22.3	C3L-02890	0.0003	0	0.0002	0	0.0003	0.0003	0.0015	0.0006	rs138638304	1.19	T	T	D	P	N	N	L	T	N	0.149	T	T	T	0.081	.	0.438	0.188	T	T	T	T	T	.	2.585	22.600	0.997	N	N	0.185	3.237	0.132	2.869	1.000	0.706	0.710	0.723	0.700	.	4.370	4.370	1.606	1.112	0.592	0.064	0.999	0.995	982	Speriolin,_C-terminal	.	.	.	SPATC1L	121	0	156	10	0.0602409638554217	TRUE	NA
ENSG00000161180.11	.	BCM	GRCh38.p13	chr22	21635163	21635163	+	G	G	A	Missense_Mutation	SNP	ENST00000292779.4	exon4	c.G1100A	p.R367H	exonic	ENSG00000161180.11	.	nonsynonymous SNV	ENSG00000161180.11:ENST00000292779.4:exon4:c.G1100A:p.R367H	22q11.21	C3L-02890	5.029e-05	0	0	0	0	9.164e-05	0	0	rs9609909	0.18	T	T	.	.	N	N	N	T	N	0.060	T	T	T	0.016	.	0.040	0.232	T	T	T	T	T	T	-0.182	0.557	0.859	N	N	-1.988	0.010	-2.037	0.011	1.000	0.581	0.547	0.576	0.613	.	4.170	-8.350	-1.011	-2.110	-2.481	0.000	0.000	0.000	946	.	.	.	.	CCDC116	126	0	254	18	0.0661764705882353	TRUE	NA
ENSG00000183530.14	.	BCM	GRCh38.p13	chr22	31713619	31713619	+	C	C	T	Missense_Mutation	SNP	ENST00000327423.11	exon4	c.G4220A	p.R1407H	exonic	ENSG00000183530.14	.	nonsynonymous SNV	ENSG00000183530.14:ENST00000327423.11:exon4:c.G4220A:p.R1407H	22q12.2	C3L-02890	.	.	.	.	.	.	.	.	rs773119037	1.20	T	T	B	B	N	N	N	T	N	0.041	T	T	D	0.026	0.167	0.043	0.081	T	T	T	T	T	T	-0.271	0.359	0.136	N	N	-1.412	0.112	-1.357	0.174	0.037	0.707	0.725	0.725	0.714	.	5.470	-0.390	0.013	0.204	-0.113	0.000	0.021	0.003	155	.	.	.	ID=COSV57883076;OCCURENCE=4(large_intestine)	PRR14L	350	0	599	52	0.0798771121351766	TRUE	TRUE
ENSG00000102290.22	.	BCM	GRCh38.p13	chrX	91876975	91876975	+	C	C	A	Missense_Mutation	SNP	ENST00000373094.5	exon2	c.C735A	p.N245K	exonic	ENSG00000102290.22	.	nonsynonymous SNV	ENSG00000102290.22:ENST00000373094.5:exon2:c.C735A:p.N245K	Xq21.31	C3L-02890	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	H	T	D	0.895	D	D	D	0.491	0.706	0.948	2.476	T	T	T	T	D	D	1.310	14.460	0.997	N	.	.	.	.	.	0.000	.	.	.	.	.	4.630	3.740	-0.216	0.085	0.549	0.007	0.866	0.979	974	Cadherin_conserved_site;Cadherin-like	.	.	.	PCDH11X	234	0	380	24	0.0594059405940594	NA	TRUE
ENSG00000147255.19	.	BCM	GRCh38.p13	chrX	131281245	131281245	+	C	C	T	Missense_Mutation	SNP	ENST00000361420.8	exon9	c.G1619A	p.R540K	exonic	ENSG00000147255.19	.	nonsynonymous SNV	ENSG00000147255.19:ENST00000361420.8:exon9:c.G1619A:p.R540K	Xq26.1	C3L-02890	.	.	.	.	.	.	.	.	.	2.19	D	D	B	B	N	N	N	T	N	0.209	T	T	T	0.054	.	0.068	0.189	T	T	T	T	T	T	0.172	2.812	0.970	N	.	.	.	.	.	0.990	.	.	.	.	.	4.100	1.340	0.255	-0.788	-0.908	0.969	0.566	0.006	61	.	.	.	.	IGSF1	102	1	232	17	0.0682730923694779	TRUE	NA
ENSG00000130338.13	.	BCM	GRCh38.p13	chr6	158413195	158413195	+	T	T	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000130338.13	ENST00000367097.8:exon2:c.381+2T>G	.	.	6q25.3	C3L-02890	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.557	34	0.995	D	.	1.112	18.025	0.960	16.591	1.000	0.099	0.105	0.084	0.090	0.987	6.020	6.020	7.894	1.138	0.665	1.000	0.992	0.628	912	.	.	.	.	TULP4	54	0	86	6	0.0652173913043478	TRUE	TRUE
ENSG00000132688.11	.	BCM	GRCh38.p13	chr1	156676548	156676548	+	C	C	T	Silent	SNP	ENST00000368223.4	exon1	c.G717A	p.R239R	exonic	ENSG00000132688.11	.	synonymous SNV	ENSG00000132688.11:ENST00000368223.4:exon1:c.G717A:p.R239R	1q23.1	C3L-02890	1.22e-05	0	0	0	0	2.258e-05	0	0	rs775804285	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NES	373	0	715	76	0.0960809102402023	TRUE	NA
ENSG00000116147.17	.	BCM	GRCh38.p13	chr1	175379619	175379619	+	C	C	T	Silent	SNP	ENST00000367674.7	exon9	c.G1896A	p.A632A	exonic	ENSG00000116147.17	.	synonymous SNV	ENSG00000116147.17:ENST00000367674.7:exon9:c.G1896A:p.A632A	1q25.1	C3L-02890	1.648e-05	0	8.645e-05	0	0	1.499e-05	0	0	rs763935322	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TNR	188	0	342	18	0.05	TRUE	NA
ENSG00000170128.5	.	BCM	GRCh38.p13	chr1	200873415	200873415	+	C	C	T	Silent	SNP	ENST00000304244.5	exon1	c.C378T	p.G126G	exonic	ENSG00000170128.5	.	synonymous SNV	ENSG00000170128.5:ENST00000304244.5:exon1:c.C378T:p.G126G	1q32.1	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPR25	335	0	454	32	0.065843621399177	TRUE	TRUE
ENSG00000178171.10	.	BCM	GRCh38.p13	chr2	130762606	130762606	+	G	G	A	Silent	SNP	ENST00000423981.1	exon2	c.G534A	p.A178A	exonic	ENSG00000178171.10	.	synonymous SNV	ENSG00000178171.10:ENST00000423981.1:exon2:c.G534A:p.A178A	2q21.1	C3L-02890	8.404e-06	0.0001	0	0	0	0	0	0	rs375834725	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100366251;OCCURENCE=1(stomach)	AMER3	171	0	311	25	0.0744047619047619	TRUE	NA
ENSG00000144229.12	.	BCM	GRCh38.p13	chr2	137642633	137642633	+	G	G	A	Silent	SNP	ENST00000409968.6	exon21	c.G3945A	p.E1315E	exonic	ENSG00000144229.12	.	synonymous SNV	ENSG00000144229.12:ENST00000409968.6:exon21:c.G3945A:p.E1315E	2q22.1	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	THSD7B	111	0	195	25	0.113636363636364	TRUE	TRUE
ENSG00000172139.15	.	BCM	GRCh38.p13	chr3	112278756	112278756	+	C	C	T	Silent	SNP	ENST00000305815.10	exon4	c.G291A	p.T97T	exonic	ENSG00000172139.15	.	synonymous SNV	ENSG00000172139.15:ENST00000305815.10:exon4:c.G291A:p.T97T	3q13.2	C3L-02890	0.0001	9.671e-05	0.0003	0	0	0.0001	0	0	rs200555832	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC9C1	142	0	284	18	0.0596026490066225	TRUE	NA
ENSG00000071794.16	.	BCM	GRCh38.p13	chr3	149074255	149074255	+	C	C	T	Silent	SNP	ENST00000310053.10	exon4	c.G489A	p.Q163Q	exonic	ENSG00000071794.16	.	synonymous SNV	ENSG00000071794.16:ENST00000310053.10:exon4:c.G489A:p.Q163Q	3q24	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HLTF	156	0	290	16	0.0522875816993464	TRUE	TRUE
ENSG00000106012.18	.	BCM	GRCh38.p13	chr7	2610048	2610048	+	C	C	G	Silent	SNP	ENST00000402050.7	exon22	c.C1974G	p.P658P	exonic	ENSG00000106012.18	.	synonymous SNV	ENSG00000106012.18:ENST00000402050.7:exon22:c.C1974G:p.P658P	7p22.3	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IQCE	121	0	251	17	0.0634328358208955	TRUE	NA
ENSG00000020577.14	.	BCM	GRCh38.p13	chr14	54760247	54760247	+	G	G	A	Silent	SNP	ENST00000554335.6	exon7	c.G1263A	p.P421P	exonic	ENSG00000020577.14	.	synonymous SNV	ENSG00000020577.14:ENST00000554335.6:exon7:c.G1263A:p.P421P	14q22.2	C3L-02890	1.737e-05	0	0	0	0	3.189e-05	0	0	rs763459461	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SAMD4A	356	0	711	74	0.0942675159235669	TRUE	NA
ENSG00000254585.5	.	BCM	GRCh38.p13	chr15	23645097	23645097	+	G	G	A	Silent	SNP	ENST00000650528.1	exon1	c.C2646T	p.S882S	exonic	ENSG00000254585.5	.	synonymous SNV	ENSG00000254585.5:ENST00000650528.1:exon1:c.C2646T:p.S882S	15q11.2	C3L-02890	6.641e-05	0	0.0004	0.0001	0	3.007e-05	0	0	rs747679005	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58566556;OCCURENCE=2(large_intestine),3(endometrium)	MAGEL2	402	0	639	57	0.0818965517241379	TRUE	TRUE
ENSG00000073670.14	.	BCM	GRCh38.p13	chr17	44778228	44778228	+	G	G	A	Silent	SNP	ENST00000200557.11	exon25	c.G2262A	p.T754T	exonic	ENSG00000073670.14	.	synonymous SNV	ENSG00000073670.14:ENST00000200557.11:exon25:c.G2262A:p.T754T	17q21.31	C3L-02890	0.0001	0	0	0	0	0	0	0.0008	rs575543165	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52344884;OCCURENCE=1(large_intestine)	ADAM11	154	0	321	27	0.0775862068965517	TRUE	TRUE
ENSG00000183034.13	.	BCM	GRCh38.p13	chr17	74930739	74930739	+	C	C	T	Silent	SNP	ENST00000331427.9	exon6	c.C1104T	p.D368D	exonic	ENSG00000183034.13	.	synonymous SNV	ENSG00000183034.13:ENST00000331427.9:exon6:c.C1104T:p.D368D	17q25.1	C3L-02890	.	.	.	.	.	.	.	.	rs768778471	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58882465;OCCURENCE=1(central_nervous_system),1(stomach),1(endometrium)	OTOP2	283	0	573	47	0.0758064516129032	TRUE	TRUE
ENSG00000234775.2	.	BCM	GRCh38.p13	chr1	203128324	203128324	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000234775.2	.	.	.	1q32.1	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC105940.2	162	0	341	22	0.0606060606060606	TRUE	NA
ENSG00000188566.14	.	BCM	GRCh38.p13	chr9	137205776	137205776	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000188566.14	ENST00000371521.8:c.-2C>T	.	.	9q34.3	C3L-02890	8.841e-06	0	0	0	0.0002	0	0	0	rs752203472	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100641649;OCCURENCE=1(thyroid)	NDOR1	437	0	801	98	0.109010011123471	TRUE	NA
ENSG00000041515.16	.	BCM	GRCh38.p13	chr13	108886447	108886447	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000041515.16	.	.	.	13q33.3	C3L-02890	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51796343;OCCURENCE=1(pancreas)	MYO16	226	0	408	43	0.0953436807095344	TRUE	NA
ENSG00000184155.8	.	BCM	GRCh38.p13	chr1	159535258	159535258	+	G	G	T	Missense_Mutation	SNP	ENST00000334857.3	exon1	c.C750A	p.H250Q	exonic	ENSG00000184155.8	.	nonsynonymous SNV	ENSG00000184155.8:ENST00000334857.3:exon1:c.C750A:p.H250Q	1q23.2	C3L-02116	.	.	.	.	.	.	.	.	.	5.19	D	T	D	D	.	N	N	T	D	0.276	T	T	T	0.062	0.437	0.546	0.284	T	T	T	T	D	T	2.070	19.790	0.982	N	N	-0.118	2.119	-0.316	1.532	0.000	0.487	0.574	0.574	0.564	.	3.980	2.010	0.331	1.176	0.618	0.004	0.887	0.627	866	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58386920;OCCURENCE=1(lung)	OR10J5	396	0	413	52	0.111827956989247	TRUE	TRUE
ENSG00000181218.5	.	BCM	GRCh38.p13	chr1	228457616	228457616	+	C	C	T	Missense_Mutation	SNP	ENST00000366695.3	exon1	c.G202A	p.G68S	exonic	ENSG00000181218.5	.	nonsynonymous SNV	ENSG00000181218.5:ENST00000366695.3:exon1:c.G202A:p.G68S	1q42.13	C3L-02116	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	M	T	D	0.868	D	D	D	0.558	0.708	0.890	2.133	D	T	D	D	D	.	4.052	27.400	0.996	D	D	0.779	8.386	0.635	6.694	1.000	0.442	0.522	0.504	0.373	.	3.840	3.840	5.654	1.026	0.599	1.000	0.966	0.829	320	Histone_H2A/H2B/H3	.	.	.	H2AW	618	0	745	67	0.082512315270936	TRUE	TRUE
ENSG00000133401.16	.	BCM	GRCh38.p13	chr5	31799547	31799547	+	G	G	A	Missense_Mutation	SNP	ENST00000438447.2	exon2	c.G299A	p.R100H	exonic	ENSG00000133401.16	.	nonsynonymous SNV	ENSG00000133401.16:ENST00000438447.2:exon2:c.G299A:p.R100H	5p13.3	C3L-02116	.	.	.	.	.	.	.	.	rs753717715	11.20	D	D	D	D	D	D	N	T	N	0.214	T	T	D	0.351	0.420	0.812	1.097	T	T	T	T	D	D	4.077	27.600	0.999	D	D	0.665	6.657	0.714	8.027	1.000	0.554	0.563	0.602	0.564	.	5.670	5.670	7.106	1.176	0.676	1.000	0.998	0.997	926	PDZ_domain	.	.	ID=COSV56875257;OCCURENCE=1(liver)	PDZD2	600	0	789	88	0.100342075256556	NA	TRUE
ENSG00000249437.8	.	BCM	GRCh38.p13	chr5	71012795	71012795	+	C	C	T	Missense_Mutation	SNP	ENST00000517649.6	exon4	c.G121A	p.E41K	exonic	ENSG00000249437.8	.	nonsynonymous SNV	ENSG00000249437.8:ENST00000517649.6:exon4:c.G121A:p.E41K	5q13.2	C3L-02116	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.197	T	T	T	0.102	0.434	0.414	0.180	T	T	T	T	T	T	-0.055	1.027	0.900	N	N	-1.338	0.145	-1.408	0.147	0.992	0.554	0.588	0.658	0.530	.	3.250	-1.750	-0.266	-0.528	-1.159	0.000	0.008	0.001	964	.	.	.	.	NAIP	580	0	534	32	0.0565371024734982	TRUE	TRUE
ENSG00000145700.10	.	BCM	GRCh38.p13	chr5	75146161	75146161	+	C	C	-	Frame_Shift_Del	NA	ENST00000274361.3	exon14	c.3250delG	p.V1084Lfs*6	exonic	ENSG00000145700.10	.	frameshift deletion	ENSG00000145700.10:ENST00000274361.3:exon14:c.3250delG:p.V1084Lfs*6	5q13.3	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANKRD31	218	0	139	23	0.141975308641975	TRUE	TRUE
ENSG00000197226.12	.	BCM	GRCh38.p13	chr5	179879167	179879167	+	G	G	A	Missense_Mutation	SNP	ENST00000356834.7	exon9	c.C1447T	p.H483Y	exonic	ENSG00000197226.12	.	nonsynonymous SNV	ENSG00000197226.12:ENST00000356834.7:exon9:c.C1447T:p.H483Y	5q35.3	C3L-02116	.	.	.	.	.	.	.	.	.	4.19	D	D	B	B	N	N	N	T	N	0.392	T	T	D	0.043	0.450	0.236	0.248	T	T	T	T	T	.	1.514	15.820	0.977	D	N	-0.799	0.656	-0.677	0.932	0.526	0.707	0.702	0.723	0.714	.	5.280	-1.740	1.442	0.191	-0.156	1.000	0.961	0.876	912	.	.	.	.	TBC1D9B	269	1	377	57	0.131336405529954	TRUE	TRUE
ENSG00000156508.18	.	BCM	GRCh38.p13	chr6	73518605	73518605	+	C	C	T	Missense_Mutation	SNP	ENST00000309268.11	exon6	c.G778A	p.G260S	exonic	ENSG00000156508.18	.	nonsynonymous SNV	ENSG00000156508.18:ENST00000309268.11:exon6:c.G778A:p.G260S	6q13	C3L-02116	.	.	.	.	.	.	.	.	.	16.19	D	D	P	B	U	D	.	D	D	0.923	D	D	D	0.905	0.848	0.975	1.723	D	D	D	D	D	D	4.777	33	0.998	D	D	0.656	6.549	0.610	6.357	1.000	0.628	0.672	0.686	0.639	.	4.710	4.710	7.573	1.005	0.599	1.000	0.998	0.898	917	Translation_elongation_factor_EFTu-like,_domain_2	.	.	ID=COSV58549690;OCCURENCE=1(skin)	EEF1A1	246	0	319	25	0.0726744186046512	TRUE	TRUE
ENSG00000104313.20	.	BCM	GRCh38.p13	chr8	71271813	71271813	+	C	C	T	Missense_Mutation	SNP	ENST00000340726.8	exon10	c.G911A	p.R304H	exonic	ENSG00000104313.20	.	nonsynonymous SNV	ENSG00000104313.20:ENST00000340726.8:exon10:c.G911A:p.R304H	8q13.3	C3L-02116	.	.	.	.	.	.	.	.	rs1036380891	20.20	D	D	D	D	D	D	M	D	D	0.682	D	D	D	0.591	0.452	0.829	0.922	D	D	D	D	D	D	4.143	28.100	1.000	D	D	0.849	9.825	0.835	11.233	1.000	0.554	0.574	0.618	0.564	.	5.700	5.700	7.520	1.026	0.599	1.000	1.000	0.999	440	.	.	.	ID=COSV58159592;OCCURENCE=1(kidney)	EYA1	1076	2	1066	105	0.089666951323655	NA	TRUE
ENSG00000122728.6	.	BCM	GRCh38.p13	chr9	32633085	32633085	+	C	C	T	Missense_Mutation	SNP	ENST00000242310.4	exon1	c.G2495A	p.R832H	exonic	ENSG00000122728.6	.	nonsynonymous SNV	ENSG00000122728.6:ENST00000242310.4:exon1:c.G2495A:p.R832H	9p21.1	C3L-02116	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	H	T	D	0.610	T	T	T	0.475	0.771	0.576	0.307	T	T	T	T	D	D	3.084	23.600	0.999	D	N	0.421	4.477	0.192	3.147	0.979	0.638	0.670	0.659	0.655	.	1.190	1.190	5.164	0.258	0.222	1.000	0.979	0.958	835	Transcription_initiation_factor_TFIID_subunit_1,_domain_of_unknown_function	.	.	ID=COSV54258209;OCCURENCE=3(breast),1(liver),2(large_intestine),1(stomach)	TAF1L	1118	2	1105	110	0.0905349794238683	NA	TRUE
ENSG00000165606.8	.	BCM	GRCh38.p13	chr10	49390222	49390222	+	C	C	T	Missense_Mutation	SNP	ENST00000374139.6	exon3	c.G145A	p.E49K	exonic	ENSG00000165606.8	.	nonsynonymous SNV	ENSG00000165606.8:ENST00000374139.6:exon3:c.G145A:p.E49K	10q11.23	C3L-02116	.	.	.	.	.	.	.	.	.	18.18	D	D	.	.	D	D	M	D	D	0.909	D	D	D	0.960	.	0.938	0.759	D	D	D	D	D	D	3.981	26.800	0.999	D	D	1.008	14.174	0.933	15.236	1.000	0.497	0.590	0.578	0.530	.	5.600	5.600	7.568	1.026	0.599	1.000	0.944	0.960	830	Homeobox_domain	.	.	ID=COSV65136841;OCCURENCE=3(large_intestine)	DRGX	372	0	343	36	0.0949868073878628	TRUE	TRUE
ENSG00000197658.9	.	BCM	GRCh38.p13	chr11	63096066	63096066	+	C	C	T	Missense_Mutation	SNP	ENST00000612278.4	exon6	c.G995A	p.R332Q	exonic	ENSG00000197658.9	.	nonsynonymous SNV	ENSG00000197658.9:ENST00000612278.4:exon6:c.G995A:p.R332Q	11q12.3	C3L-02116	.	.	.	.	.	.	.	.	rs371518525	0.17	T	T	B	B	.	N	.	T	N	0.082	T	T	T	0.135	0.719	0.148	0.006	T	.	T	T	T	T	0.365	5.030	0.255	N	N	-1.807	0.023	-1.714	0.048	0.000	0.487	0.574	0.574	0.530	.	3.680	1.280	0.085	-0.377	-0.896	0.037	0.000	0.000	809	Major_facilitator_superfamily_domain	.	.	ID=COSV70301809;OCCURENCE=2(skin)	SLC22A24	336	0	336	29	0.0794520547945206	TRUE	NA
ENSG00000186635.14	.	BCM	GRCh38.p13	chr11	72726701	72726701	+	G	G	A	Missense_Mutation	SNP	ENST00000393609.7	exon3	c.C428T	p.P143L	exonic	ENSG00000186635.14	.	nonsynonymous SNV	ENSG00000186635.14:ENST00000393609.7:exon3:c.C428T:p.P143L	11q13.4	C3L-02116	0	0	0	0	0	0	0	0	rs372690916	8.20	D	D	B	B	N	D	L	T	D	0.526	T	T	D	0.120	.	0.378	1.071	T	T	T	T	T	D	2.653	22.700	0.999	D	D	-0.053	2.330	0.063	2.589	1.000	0.745	0.725	0.732	0.655	.	4.860	4.860	5.382	1.176	0.676	1.000	0.887	0.092	455	.	.	.	.	ARAP1	141	0	191	30	0.135746606334842	TRUE	NA
ENSG00000095110.8	.	BCM	GRCh38.p13	chr11	114522486	114522486	+	G	G	A	Missense_Mutation	SNP	ENST00000534921.2	exon9	c.C1126T	p.L376F	exonic	ENSG00000095110.8	.	nonsynonymous SNV	ENSG00000095110.8:ENST00000534921.2:exon9:c.C1126T:p.L376F	11q23.2	C3L-02116	.	.	.	.	.	.	.	.	.	5.20	T	T	D	D	N	N	M	T	N	0.255	T	T	T	0.274	0.659	0.286	0.158	T	T	T	T	D	T	3.172	23.800	0.998	D	N	0.369	4.156	0.277	3.586	0.004	0.487	0.590	0.574	0.564	.	4.440	2.480	2.575	1.176	0.676	1.000	1.000	0.997	889	.	.	.	.	NXPE1	106	0	131	16	0.108843537414966	TRUE	NA
ENSG00000215009.5	.	BCM	GRCh38.p13	chr12	7322471	7322471	+	C	C	G	Missense_Mutation	SNP	ENST00000399422.4	exon7	c.C1055G	p.P352R	exonic	ENSG00000215009.5	.	nonsynonymous SNV	ENSG00000215009.5:ENST00000399422.4:exon7:c.C1055G:p.P352R	12p13.31	C3L-02116	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	U	D	M	T	D	0.553	T	T	T	0.286	0.560	0.517	0.444	T	T	T	T	D	D	3.672	25.300	0.998	D	D	0.536	5.331	0.451	4.742	0.005	0.554	0.588	0.574	0.586	.	3.270	3.270	6.363	0.071	0.426	1.000	0.248	0.921	702	AMP-dependent_synthetase/ligase	.	.	.	ACSM4	351	0	453	53	0.104743083003953	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227341	25227341	+	T	T	G	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A183C	p.Q61H	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A183C:p.Q61H	12p12.1	C3L-02116	.	.	.	.	.	.	.	.	rs17851045	17.20	D	D	B	B	D	D	M	D	D	0.760	D	D	D	0.644	0.659	0.905	1.857	D	D	D	D	D	T	2.993	23.400	0.997	D	D	0.298	3.768	0.383	4.239	0.998	0.722	0.710	0.710	0.735	.	5.770	5.770	2.812	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55498802;OCCURENCE=2(breast),6(liver),1(genital_tract),1(cervix),117(large_intestine),2(central_nervous_system),17(biliary_tract),3(ovary),8(stomach),50(haematopoietic_and_lymphoid_tissue),2(urinary_tract),1(kidney),71(pancreas),2(skin),2(prostate),28(lung),1(thyroid),2(small_intestine),5(endometrium)	KRAS	324	0	305	43	0.123563218390805	TRUE	TRUE
ENSG00000139354.11	.	BCM	GRCh38.p13	chr12	100622330	100622330	+	A	A	G	Missense_Mutation	SNP	ENST00000547754.6	exon9	c.A704G	p.E235G	exonic	ENSG00000139354.11	.	nonsynonymous SNV	ENSG00000139354.11:ENST00000547754.6:exon9:c.A704G:p.E235G	12q23.1	C3L-02116	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.949	T	T	T	0.575	0.544	0.606	0.481	D	T	D	D	D	D	4.312	29.700	0.999	D	D	0.763	8.106	0.744	8.662	1.000	0.651	0.547	0.618	0.684	.	5.900	5.900	8.559	1.312	0.756	1.000	1.000	0.997	586	GAR_domain	.	.	.	GAS2L3	222	0	176	18	0.0927835051546392	TRUE	TRUE
ENSG00000139354.11	.	BCM	GRCh38.p13	chr12	100624055	100624055	+	C	C	A	Missense_Mutation	SNP	ENST00000547754.6	exon10	c.C1250A	p.S417Y	exonic	ENSG00000139354.11	.	nonsynonymous SNV	ENSG00000139354.11:ENST00000547754.6:exon10:c.C1250A:p.S417Y	12q23.1	C3L-02116	.	.	.	.	.	.	.	.	.	3.20	D	D	B	B	N	N	M	T	N	0.256	T	T	T	0.036	0.265	0.424	0.194	T	T	T	T	T	T	0.858	9.984	0.923	N	N	-0.805	0.648	-0.893	0.630	0.000	0.707	0.588	0.653	0.714	.	4.790	1.780	0.189	0.038	-0.182	0.033	0.005	0.009	590	.	.	.	.	GAS2L3	580	0	612	54	0.0810810810810811	TRUE	TRUE
ENSG00000137801.11	.	BCM	GRCh38.p13	chr15	39589884	39589884	+	A	A	G	Missense_Mutation	SNP	ENST00000260356.6	exon13	c.A2006G	p.Y669C	exonic	ENSG00000137801.11	.	nonsynonymous SNV	ENSG00000137801.11:ENST00000260356.6:exon13:c.A2006G:p.Y669C	15q14	C3L-02116	.	.	.	.	.	.	.	.	.	8.20	D	T	D	P	N	D	L	T	N	0.584	T	T	D	0.394	0.434	0.465	1.221	T	T	T	T	D	D	4.219	28.800	0.998	D	D	0.252	3.540	0.367	4.133	1.000	0.672	0.610	0.702	0.658	.	5.990	4.800	3.072	1.312	0.756	1.000	0.987	0.988	878	EGF-like_domain	.	.	.	THBS1	257	0	356	29	0.0753246753246753	TRUE	NA
ENSG00000166415.15	.	BCM	GRCh38.p13	chr15	53613727	53613727	+	C	C	A	Missense_Mutation	SNP	ENST00000360509.10	exon16	c.G2811T	p.K937N	exonic	ENSG00000166415.15	.	nonsynonymous SNV	ENSG00000166415.15:ENST00000360509.10:exon16:c.G2811T:p.K937N	15q21.3	C3L-02116	.	.	.	.	.	.	.	.	.	8.20	D	D	D	D	D	N	M	T	N	0.632	T	T	D	0.163	0.650	0.436	0.024	T	T	T	T	D	T	2.101	20.100	0.998	N	N	0.040	2.656	-0.130	1.965	0.007	0.487	0.574	0.574	0.613	.	5.290	4.380	0.185	0.074	0.549	0.093	0.020	0.176	895	.	.	.	.	WDR72	291	1	288	35	0.108359133126935	TRUE	TRUE
ENSG00000149654.11	.	BCM	GRCh38.p13	chr20	46241002	46241002	+	C	C	T	Missense_Mutation	SNP	ENST00000537909.4	exon3	c.G511A	p.G171S	exonic	ENSG00000149654.11	.	nonsynonymous SNV	ENSG00000149654.11:ENST00000537909.4:exon3:c.G511A:p.G171S	20q13.12	C3L-02116	8.408e-06	0	0	0.0001	0	0	0	0	rs754632908	12.20	D	D	D	P	D	D	N	T	D	0.854	T	T	D	0.302	0.297	0.621	.	D	T	T	T	D	D	3.621	25.100	0.998	D	D	0.278	3.669	0.306	3.754	1.000	0.516	0.610	0.602	0.542	.	4.430	4.430	7.568	1.026	0.599	1.000	0.988	0.785	442	Cadherin-like	.	.	ID=COSV64838261;OCCURENCE=1(biliary_tract)	CDH22	227	0	328	37	0.101369863013699	TRUE	TRUE
ENSG00000081479.15	.	BCM	GRCh38.p13	chr2	169243523	169243523	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000081479.15	ENST00000649046.1:exon23:c.3431-1G>A	.	.	2q31.1	C3L-02116	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.762	33	0.989	D	.	0.970	12.994	0.769	9.257	1.000	0.054	0.060	0.060	0.059	0.978	6.030	6.030	7.361	1.015	0.599	1.000	0.202	0.242	898	.	.	.	.	LRP2	471	0	375	32	0.0786240786240786	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51067188	51067188	+	G	G	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141646.14	ENST00000342988.8:exon10:c.1308+1G>C	.	.	18q21.2	C3L-02116	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.667	34	0.996	D	.	1.214	25.064	1.064	23.473	1.000	0.322	0.319	0.138	0.090	0.984	5.170	5.170	9.819	1.176	0.676	1.000	0.995	0.971	886	.	.	.	ID=COSV61690413;OCCURENCE=1(endometrium)	SMAD4	417	0	314	49	0.134986225895317	TRUE	TRUE
ENSG00000162437.14	.	BCM	GRCh38.p13	chr1	64745352	64745352	+	G	G	A	Silent	SNP	ENST00000294428.7	exon1	c.G180A	p.R60R	exonic	ENSG00000162437.14	.	synonymous SNV	ENSG00000162437.14:ENST00000294428.7:exon1:c.G180A:p.R60R	1p31.3	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAVER2	316	1	313	47	0.130555555555556	TRUE	TRUE
ENSG00000183873.17	.	BCM	GRCh38.p13	chr3	38604882	38604882	+	G	G	A	Silent	SNP	ENST00000333535.9	exon11	c.C1365T	p.T455T	exonic	ENSG00000183873.17	.	synonymous SNV	ENSG00000183873.17:ENST00000333535.9:exon11:c.C1365T:p.T455T	3p22.2	C3L-02116	1.898e-05	0	0	0	0	1.697e-05	0	7.029e-05	rs747138429	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCN5A	261	0	272	46	0.144654088050314	TRUE	NA
ENSG00000249437.8	.	BCM	GRCh38.p13	chr5	71012883	71012883	+	C	C	T	Silent	SNP	ENST00000517649.6	exon4	c.G33A	p.R11R	exonic	ENSG00000249437.8	.	synonymous SNV	ENSG00000249437.8:ENST00000517649.6:exon4:c.G33A:p.R11R	5q13.2	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NAIP	243	0	232	14	0.0569105691056911	TRUE	TRUE
ENSG00000261934.2	.	BCM	GRCh38.p13	chr5	141403351	141403351	+	C	C	T	Silent	SNP	ENST00000573521.1	exon1	c.C399T	p.F133F	exonic	ENSG00000261934.2	.	synonymous SNV	ENSG00000261934.2:ENST00000573521.1:exon1:c.C399T:p.F133F	5q31.3	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHGA9	360	0	484	57	0.105360443622921	TRUE	TRUE
ENSG00000133878.9	.	BCM	GRCh38.p13	chr8	33593627	33593627	+	C	C	T	Silent	SNP	ENST00000256261.9	exon3	c.G342A	p.L114L	exonic	ENSG00000133878.9	.	synonymous SNV	ENSG00000133878.9:ENST00000256261.9:exon3:c.G342A:p.L114L	8p12	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DUSP26	492	1	779	100	0.113765642775882	TRUE	NA
ENSG00000148408.13	.	BCM	GRCh38.p13	chr9	138121678	138121678	+	C	C	T	Silent	SNP	ENST00000371372.6	exon47	c.C6699T	p.S2233S	exonic	ENSG00000148408.13	.	synonymous SNV	ENSG00000148408.13:ENST00000371372.6:exon47:c.C6699T:p.S2233S	9q34.3	C3L-02116	5.022e-05	0	8.688e-05	0	0	7.591e-05	0	0	rs200996202	8.14	D	D	.	.	.	D	.	D	N	0.056	T	D	D	0.315	0.289	0.502	.	.	.	D	D	T	T	-0.264	0.371	0.953	N	N	-1.403	0.116	-1.620	0.070	1.000	0.646	0.590	0.645	0.613	.	5.110	-10.200	-5.293	-1.456	-1.078	0.000	0.961	0.722	994	.	.	.	ID=COSV53136715;OCCURENCE=1(large_intestine)	CACNA1B	204	0	305	48	0.135977337110482	TRUE	TRUE
ENSG00000075826.17	.	BCM	GRCh38.p13	chr10	100509397	100509397	+	C	C	T	Silent	SNP	ENST00000370345.8	exon4	c.G318A	p.L106L	exonic	ENSG00000075826.17	.	synonymous SNV	ENSG00000075826.17:ENST00000370345.8:exon4:c.G318A:p.L106L	10q24.31	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEC31B	333	0	345	20	0.0547945205479452	TRUE	TRUE
ENSG00000185100.10	.	BCM	GRCh38.p13	chr14	104744824	104744824	+	G	G	A	Silent	SNP	ENST00000330877.6	exon11	c.G1086A	p.T362T	exonic	ENSG00000185100.10	.	synonymous SNV	ENSG00000185100.10:ENST00000330877.6:exon11:c.G1086A:p.T362T	14q32.33	C3L-02116	1.653e-05	0	0	0	0	0	0	0.0001	rs760343931	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58272681;OCCURENCE=1(endometrium)	ADSS1	288	0	278	34	0.108974358974359	TRUE	TRUE
ENSG00000159495.8	.	BCM	GRCh38.p13	chr15	43292878	43292878	+	G	G	A	Silent	SNP	ENST00000452443.3	exon3	c.C270T	p.S90S	exonic	ENSG00000159495.8	.	synonymous SNV	ENSG00000159495.8:ENST00000452443.3:exon3:c.C270T:p.S90S	15q15.2	C3L-02116	8.247e-06	0	0	0.0001	0	0	0	0	rs753185732	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101476840;OCCURENCE=2(central_nervous_system)	TGM7	582	1	674	51	0.0703448275862069	TRUE	NA
ENSG00000103876.13	.	BCM	GRCh38.p13	chr15	80162322	80162322	+	G	G	T	Silent	SNP	ENST00000561421.6	exon5	c.G441T	p.A147A	exonic	ENSG00000103876.13	.	synonymous SNV	ENSG00000103876.13:ENST00000561421.6:exon5:c.G441T:p.A147A	15q25.1	C3L-02116	1.647e-05	0	0	0	0	2.997e-05	0	0	rs141863249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAH	710	1	805	51	0.0595794392523364	TRUE	NA
ENSG00000157423.18	.	BCM	GRCh38.p13	chr16	71027620	71027620	+	G	G	A	Silent	SNP	ENST00000393567.7	exon20	c.C3024T	p.G1008G	exonic	ENSG00000157423.18	.	synonymous SNV	ENSG00000157423.18:ENST00000393567.7:exon20:c.C3024T:p.G1008G	16q22.2	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HYDIN	574	0	723	74	0.0928481806775408	NA	TRUE
ENSG00000131746.13	.	BCM	GRCh38.p13	chr17	40487133	40487133	+	G	G	T	Silent	SNP	ENST00000254051.11	exon4	c.C1191A	p.S397S	exonic	ENSG00000131746.13	.	synonymous SNV	ENSG00000131746.13:ENST00000254051.11:exon4:c.C1191A:p.S397S	17q21.2	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TNS4	613	1	772	84	0.0981308411214953	TRUE	TRUE
ENSG00000087074.8	.	BCM	GRCh38.p13	chr19	48875904	48875904	+	T	T	A	Silent	SNP	ENST00000200453.6	exon3	c.T1956A	p.A652A	exonic	ENSG00000087074.8	.	synonymous SNV	ENSG00000087074.8:ENST00000200453.6:exon3:c.T1956A:p.A652A	19q13.33	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPP1R15A	165	0	153	23	0.130681818181818	TRUE	TRUE
ENSG00000213057.5	.	BCM	GRCh38.p13	chr1	178545707	178545707	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000213057.5	.	.	.	1q25.2	C3L-02116	4.12e-05	0.0002	0	0.0001	0.0002	0	0	6.056e-05	rs145498551	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C1orf220	439	0	500	53	0.0958408679927667	TRUE	NA
ENSG00000225182.1	.	BCM	GRCh38.p13	chr2	166903777	166903777	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000225182.1;ENSG00000254552.1	dist=13893;dist=220127	.	.	2q24.3	C3L-02116	.	.	.	.	.	.	.	.	.	7.17	D	D	P	P	.	N	.	D	N	0.253	T	D	D	0.152	0.162	0.453	0.104	T	.	T	T	D	T	2.346	21.800	0.999	D	N	0.243	3.500	0.188	3.125	0.015	0.554	0.574	0.618	0.564	.	5.120	5.120	3.261	1.176	0.676	0.996	0.763	0.048	272	.	.	.	ID=COSV54687771;OCCURENCE=2(skin)	AC092601.1	529	0	597	36	0.0568720379146919	TRUE	TRUE
ENSG00000242428.6	.	BCM	GRCh38.p13	chr3	58913699	58913699	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000242428.6	.	.	.	3p14.2	C3L-02116	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C3orf67-AS1	527	0	435	42	0.0880503144654088	TRUE	NA
ENSG00000163749.17	.	BCM	GRCh38.p13	chr4	76375701	76375701	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000163749.17	.	.	.	4q21.1	C3L-02116	.	.	.	.	.	.	.	.	.	2.16	T	T	B	B	.	D	.	T	N	0.230	T	T	T	0.046	0.118	0.254	.	.	.	T	T	T	T	2.206	20.900	0.964	D	N	-0.528	1.121	-0.409	1.356	0.982	0.487	0.574	0.547	0.542	.	5.810	3.210	2.251	0.065	-0.171	1.000	0.998	0.912	767	.	.	.	.	CCDC158	152	0	110	16	0.126984126984127	TRUE	NA
ENSG00000187955.12	.	BCM	GRCh38.p13	chr8	120370335	120370335	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000187955.12	.	.	.	8q24.12	C3L-02116	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	3.463	24.600	0.995	D	.	0.367	4.144	0.438	4.639	1.000	0.075	0.063	0.079	0.059	0.975	4.990	4.990	6.068	1.176	0.676	1.000	0.977	0.746	691	.	.	.	.	COL14A1	263	1	230	26	0.1015625	TRUE	NA
ENSG00000198855.7	.	BCM	GRCh38.p13	chr12	108518258	108518258	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000198855.7	.	.	.	12q23.3	C3L-02116	.	.	.	.	.	.	.	.	rs774851840	1.12	D	.	.	.	.	N	.	.	N	0.134	T	T	T	0.010	0.292	0.340	.	.	.	T	T	T	T	-1.170	0.003	0.617	N	N	-1.339	0.144	-1.562	0.086	1.000	0.406	0.380	0.487	0.509	.	3.250	-4.320	-4.132	-2.519	-1.916	0.000	0.000	0.000	888	.	.	.	.	FICD	688	0	841	78	0.0848748639825898	TRUE	NA
ENSG00000167798.17	.	BCM	GRCh38.p13	chr19	10049999	10049999	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000167798.17	.	.	.	19p13.2	C3L-02116	1.657e-05	0	0	0	0	2.999e-05	0	0	rs771970106	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C3P1	262	0	260	19	0.0681003584229391	TRUE	NA
ENSG00000283685.1	.	BCM	GRCh38.p13	chr19	53751240	53751240	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000283685.1	.	.	.	19q13.42	C3L-02116	6.617e-05	0.0002	0	0	0	9.05e-05	0	0	rs146976572	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR522	298	0	206	15	0.0678733031674208	TRUE	NA
ENSG00000116690.13	.	BCM	GRCh38.p13	chr1	186312232	186312232	+	G	G	A	Missense_Mutation	SNP	ENST00000445192.7	exon11	c.G3851A	p.R1284K	exonic	ENSG00000116690.13	.	nonsynonymous SNV	ENSG00000116690.13:ENST00000445192.7:exon11:c.G3851A:p.R1284K	1q31.1	C3L-01453	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	N	0.220	T	T	T	0.055	0.347	0.040	0.036	T	T	T	T	D	T	2.792	23.000	0.961	N	D	-0.219	1.824	-0.145	1.923	0.831	0.372	0.546	0.487	0.492	.	5.380	4.460	2.349	1.176	0.618	0.221	0.998	0.995	259	Hemopexin-like_domain	.	.	ID=COSV63355732;OCCURENCE=1(urinary_tract)	PRG4	264	0	397	58	0.127472527472527	TRUE	TRUE
ENSG00000172954.13	.	BCM	GRCh38.p13	chr2	30459661	30459661	+	A	A	G	Missense_Mutation	SNP	ENST00000309052.8	exon2	c.A49G	p.I17V	exonic	ENSG00000172954.13	.	nonsynonymous SNV	ENSG00000172954.13:ENST00000309052.8:exon2:c.A49G:p.I17V	2p23.1	C3L-01453	4.942e-05	0	0	0.0003	0	1.499e-05	0	0.0001	rs753684188	1.19	T	D	B	B	U	N	N	T	N	0.139	T	T	T	0.007	0.221	0.110	0.210	.	T	T	T	T	T	-0.202	0.506	0.189	N	N	-1.801	0.023	-1.898	0.022	1.000	0.554	0.546	0.527	0.568	.	2.980	-5.950	-1.141	-1.055	-0.878	0.000	0.001	0.004	946	.	.	.	.	LCLAT1	349	0	482	59	0.1090573012939	TRUE	NA
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	141229266	141229266	+	G	G	A	Missense_Mutation	SNP	ENST00000389484.8	exon6	c.C767T	p.S256L	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon6:c.C767T:p.S256L	2q22.1	C3L-01453	8.262e-06	0	0	0	0	1.502e-05	0	0	rs772492671	10.20	T	D	B	B	U	D	M	D	N	0.293	D	D	D	0.249	0.463	0.251	0.290	T	T	T	T	D	T	2.465	22.300	0.997	D	D	-0.020	2.443	0.165	3.019	0.999	0.487	0.574	0.574	0.564	.	5.200	5.200	3.688	1.176	0.618	1.000	1.000	0.998	639	.	.	.	.	LRP1B	364	0	426	56	0.116182572614108	TRUE	NA
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178579615	178579615	+	C	C	A	Nonsense_Mutation	SNP	ENST00000591111.5	exon269	c.G62659T	p.E20887X	exonic	ENSG00000155657.27	.	stopgain	ENSG00000155657.27:ENST00000591111.5:exon269:c.G62659T:p.E20887X	2q31.2	C3L-01453	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	.	A	.	.	.	0.973	.	.	.	.	.	.	.	.	.	D	D	.	.	13.508	63	0.976	D	N	1.237	27.629	1.105	27.694	1.000	0.563	0.654	0.602	0.621	.	5.780	5.780	6.123	1.026	0.599	1.000	1.000	1.000	430	Fibronectin_type_III	.	.	.	TTN	416	0	613	69	0.101173020527859	TRUE	TRUE
ENSG00000079263.19	.	BCM	GRCh38.p13	chr2	230312592	230312592	+	G	G	C	Missense_Mutation	SNP	ENST00000392045.8	exon27	c.G2512C	p.D838H	exonic	ENSG00000079263.19	.	nonsynonymous SNV	ENSG00000079263.19:ENST00000392045.8:exon27:c.G2512C:p.D838H	2q37.1	C3L-01453	.	.	.	.	.	.	.	.	.	7.19	D	D	D	P	.	N	M	T	D	0.199	T	T	T	0.035	0.420	0.414	2.281	T	T	T	T	D	D	2.335	21.800	0.983	N	N	-0.442	1.295	-0.661	0.956	0.001	0.707	0.725	0.547	0.586	.	3.300	0.135	-0.092	-0.225	-0.242	0.000	0.162	0.581	938	Bromodomain	.	.	.	SP140	215	0	255	36	0.123711340206186	TRUE	TRUE
ENSG00000060971.18	.	BCM	GRCh38.p13	chr3	38129336	38129336	+	G	G	A	Missense_Mutation	SNP	ENST00000333167.13	exon6	c.C499T	p.R167C	exonic	ENSG00000060971.18	.	nonsynonymous SNV	ENSG00000060971.18:ENST00000333167.13:exon6:c.C499T:p.R167C	3p22.2	C3L-01453	8.243e-06	0	8.646e-05	0	0	0	0	0	rs751653410	15.20	D	D	B	B	D	D	M	D	D	0.348	D	D	D	0.594	0.619	0.948	0.493	T	D	D	D	T	D	2.735	22.900	0.999	D	N	-0.054	2.326	-0.029	2.263	1.000	0.707	0.725	0.725	0.714	.	5.550	4.680	2.498	1.157	0.654	0.957	0.655	0.818	553	Thiolase,_N-terminal	.	.	.	ACAA1	161	0	239	47	0.164335664335664	TRUE	NA
ENSG00000172771.12	.	BCM	GRCh38.p13	chr3	129408671	129408671	+	G	G	A	Missense_Mutation	SNP	ENST00000505956.6	exon6	c.C1223T	p.P408L	exonic	ENSG00000172771.12	.	nonsynonymous SNV	ENSG00000172771.12:ENST00000505956.6:exon6:c.C1223T:p.P408L	3q21.3	C3L-01453	3.297e-05	0	0	0	0	6.862e-05	0	0	rs747911030	8.20	D	D	D	D	N	N	M	T	D	0.329	T	T	T	0.140	0.460	0.229	0.307	T	T	T	T	D	T	3.188	23.800	0.997	D	N	0.052	2.703	0.013	2.404	0.837	0.615	0.588	0.659	0.542	.	5.340	3.490	1.561	-0.549	-1.477	0.995	0.030	0.129	439	.	.	.	.	EFCAB12	268	0	421	63	0.130165289256198	TRUE	NA
ENSG00000071794.16	.	BCM	GRCh38.p13	chr3	149064845	149064845	+	A	A	C	Missense_Mutation	SNP	ENST00000310053.10	exon9	c.T1012G	p.S338A	exonic	ENSG00000071794.16	.	nonsynonymous SNV	ENSG00000071794.16:ENST00000310053.10:exon9:c.T1012G:p.S338A	3q24	C3L-01453	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	.	N	L	D	N	0.128	T	T	D	0.170	0.393	0.644	0.148	T	T	T	T	T	T	0.005	1.369	0.307	N	N	-1.292	0.169	-1.262	0.235	0.011	0.732	0.744	0.710	0.728	.	5.650	1.890	0.452	-0.135	-0.059	0.204	0.006	0.006	888	Helicase_superfamily_1/2,_ATP-binding_domain;SNF2-related,_N-terminal_domain	.	.	.	HLTF	194	0	302	29	0.0876132930513595	TRUE	TRUE
ENSG00000138741.11	.	BCM	GRCh38.p13	chr4	121951529	121951529	+	G	G	C	Missense_Mutation	SNP	ENST00000379645.8	exon1	c.C152G	p.S51W	exonic	ENSG00000138741.11	.	nonsynonymous SNV	ENSG00000138741.11:ENST00000379645.8:exon1:c.C152G:p.S51W	4q27	C3L-01453	.	.	.	.	.	.	.	.	.	4.16	D	D	.	.	U	N	.	T	N	0.247	T	T	D	0.126	0.307	0.327	1.058	T	.	T	T	D	T	1.849	18.100	0.960	N	N	-0.656	0.889	-0.736	0.848	1.000	0.437	0.492	0.607	0.555	.	2.780	1.900	0.212	0.993	0.616	0.000	0.139	0.055	658	.	.	.	.	TRPC3	51	0	148	18	0.108433734939759	TRUE	TRUE
ENSG00000038295.8	.	BCM	GRCh38.p13	chr4	165994492	165994492	+	C	C	A	Missense_Mutation	SNP	ENST00000061240.7	exon4	c.C473A	p.P158H	exonic	ENSG00000038295.8	.	nonsynonymous SNV	ENSG00000038295.8:ENST00000061240.7:exon4:c.C473A:p.P158H	4q32.3	C3L-01453	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	U	D	H	T	D	0.826	D	D	D	0.759	0.806	0.905	0.964	T	D	D	D	D	D	3.634	25.200	0.996	D	D	0.924	11.675	0.805	10.263	1.000	0.638	0.574	0.574	0.668	.	5.720	5.720	7.905	1.000	0.599	1.000	0.971	0.583	923	Peptidase,_metallopeptidase;Peptidase_M12A;Tolloid/BMP1_peptidase_domain	.	.	.	TLL1	343	0	486	77	0.136767317939609	TRUE	NA
ENSG00000164199.18	.	BCM	GRCh38.p13	chr5	90617898	90617898	+	G	G	A	Missense_Mutation	SNP	ENST00000405460.9	exon3	c.G302A	p.C101Y	exonic	ENSG00000164199.18	.	nonsynonymous SNV	ENSG00000164199.18:ENST00000405460.9:exon3:c.G302A:p.C101Y	5q14.3	C3L-01453	.	.	.	.	.	.	.	.	.	11.19	D	D	D	P	D	D	.	T	D	0.856	T	T	D	0.285	0.499	0.706	0.106	T	T	T	T	D	D	3.299	24.100	0.993	D	D	0.400	4.345	0.466	4.864	1.000	0.554	0.574	0.602	0.564	.	5.560	5.560	4.734	1.166	0.665	1.000	1.000	1.000	791	.	.	.	.	ADGRV1	174	0	284	47	0.141993957703928	TRUE	TRUE
ENSG00000113657.13	.	BCM	GRCh38.p13	chr5	147415789	147415789	+	C	C	G	Missense_Mutation	SNP	ENST00000398514.7	exon4	c.G398C	p.C133S	exonic	ENSG00000113657.13	.	nonsynonymous SNV	ENSG00000113657.13:ENST00000398514.7:exon4:c.G398C:p.C133S	5q32	C3L-01453	.	.	.	.	.	.	.	.	.	17.20	T	D	P	D	D	D	M	D	D	0.914	D	D	D	0.791	0.752	0.540	0.979	T	D	D	D	D	D	3.851	26.100	0.992	D	D	0.874	10.392	0.861	12.184	1.000	0.707	0.574	0.702	0.714	.	6.030	5.150	7.863	1.026	0.599	1.000	0.999	0.989	769	Amidohydrolase-related	.	.	.	DPYSL3	227	0	370	54	0.127358490566038	TRUE	TRUE
ENSG00000184347.15	.	BCM	GRCh38.p13	chr5	168708098	168708098	+	G	G	A	Missense_Mutation	SNP	ENST00000519560.6	exon26	c.C2722T	p.P908S	exonic	ENSG00000184347.15	.	nonsynonymous SNV	ENSG00000184347.15:ENST00000519560.6:exon26:c.C2722T:p.P908S	5q34	C3L-01453	.	.	.	.	.	.	.	.	.	10.20	D	D	P	B	D	D	L	T	D	0.468	T	T	D	0.507	0.531	0.299	0.526	T	T	T	T	D	D	3.992	26.900	0.998	D	D	0.319	3.880	0.399	4.355	0.953	0.615	0.563	0.659	0.613	.	4.940	4.940	5.728	1.176	0.618	1.000	0.999	0.993	947	.	.	.	.	SLIT3	188	0	355	49	0.121287128712871	TRUE	TRUE
ENSG00000106246.18	.	BCM	GRCh38.p13	chr7	99429660	99429660	+	C	C	A	Missense_Mutation	SNP	ENST00000292478.9	exon4	c.G741T	p.L247F	exonic	ENSG00000106246.18;ENSG00000248919.7	.	nonsynonymous SNV	ENSG00000106246.18:ENST00000292478.9:exon4:c.G741T:p.L247F,ENSG00000248919.7:ENST00000413834.5:exon5:c.G888T:p.L296F	7q22.1	C3L-01453	.	.	.	.	.	.	.	.	.	10.20	T	D	D	D	D	D	M	T	N	0.568	T	T	D	0.228	0.293	0.685	0.506	T	T	T	T	D	D	3.116	23.700	0.998	D	N	0.156	3.114	0.068	2.608	0.000	0.672	0.702	0.702	0.636	.	5.340	1.200	-0.234	0.122	0.596	0.593	0.996	0.997	397	Pentacotripeptide-repeat_region_of_PRORP	.	.	.	PTCD1	605	2	2111	144	0.0638580931263858	TRUE	TRUE
ENSG00000166526.18	.	BCM	GRCh38.p13	chr7	100072095	100072095	+	T	T	C	Missense_Mutation	SNP	ENST00000299667.9	exon6	c.A389G	p.Y130C	exonic	ENSG00000166526.18	.	nonsynonymous SNV	ENSG00000166526.18:ENST00000299667.9:exon6:c.A389G:p.Y130C	7q22.1	C3L-01453	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	D	N	T	N	0.188	T	T	T	0.044	0.371	0.175	0.373	T	T	T	T	T	T	1.400	15.080	0.780	N	N	-0.671	0.863	-0.563	1.103	0.799	0.672	0.702	0.702	0.711	.	4.680	2.370	0.274	1.138	0.609	0.113	1.000	0.987	137	Krueppel-associated_box	.	.	.	ZNF3	278	0	859	61	0.066304347826087	TRUE	NA
ENSG00000008282.8	.	BCM	GRCh38.p13	chr7	106091813	106091813	+	C	C	T	Missense_Mutation	SNP	ENST00000011473.6	exon6	c.G772A	p.G258R	exonic	ENSG00000008282.8	.	nonsynonymous SNV	ENSG00000008282.8:ENST00000011473.6:exon6:c.G772A:p.G258R	7q22.3	C3L-01453	3.312e-05	0	0	0.0001	0	3.013e-05	0	6.103e-05	rs773642336	5.20	D	D	D	P	N	D	L	T	N	0.194	T	T	T	0.164	0.242	0.320	0.605	T	T	T	T	T	T	3.213	23.900	0.999	D	N	0.408	4.396	0.411	4.440	1.000	0.732	0.723	0.710	0.728	.	5.770	5.770	1.813	1.026	0.594	0.939	0.688	0.897	936	.	.	.	.	SYPL1	176	0	224	47	0.173431734317343	TRUE	NA
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	3029322	3029322	+	G	G	A	Nonsense_Mutation	SNP	ENST00000635120.2	exon51	c.C7852T	p.R2618X	exonic	ENSG00000183117.19	.	stopgain	ENSG00000183117.19:ENST00000635120.2:exon51:c.C7852T:p.R2618X	8p23.2	C3L-01453	1.715e-05	0	0	0.0001	0	1.532e-05	0	0	rs766376387	5.7	.	.	.	.	N	A	.	.	.	0.940	.	.	.	.	.	.	.	.	.	D	D	D	.	7.745	39	0.976	D	N	0.134	3.024	-0.204	1.776	0.000	0.554	0.574	0.602	0.564	.	4.880	-0.495	1.912	-0.214	-0.265	0.740	0.000	0.004	964	Sushi/SCR/CCP_domain	.	.	ID=COSV59284438;OCCURENCE=1(liver),1(large_intestine),1(endometrium)	CSMD1	94	1	158	23	0.12707182320442	TRUE	TRUE
ENSG00000147789.15	.	BCM	GRCh38.p13	chr8	144842319	144842319	+	G	G	C	Missense_Mutation	SNP	ENST00000528372.5	exon5	c.G1212C	p.Q404H	exonic	ENSG00000147789.15	.	nonsynonymous SNV	ENSG00000147789.15:ENST00000528372.5:exon5:c.G1212C:p.Q404H	8q24.3	C3L-01453	.	.	.	.	.	.	.	.	.	6.19	T	D	D	P	N	N	M	T	D	0.297	T	T	T	0.076	0.485	0.210	0.086	T	T	T	T	D	T	1.739	17.300	0.994	D	.	-0.445	1.287	-0.618	1.019	0.992	0.672	0.702	0.702	0.636	.	4.790	-2.350	1.034	0.105	0.662	0.001	0.995	0.985	759	.	.	.	.	ZNF7	329	0	473	126	0.210350584307179	TRUE	TRUE
ENSG00000111679.17	.	BCM	GRCh38.p13	chr12	6952060	6952060	+	C	C	T	Missense_Mutation	SNP	ENST00000318974.14	exon3	c.C209T	p.A70V	exonic	ENSG00000111679.17	.	nonsynonymous SNV	ENSG00000111679.17:ENST00000318974.14:exon3:c.C209T:p.A70V	12p13.31	C3L-01453	.	.	.	.	.	.	.	.	.	18.20	D	D	D	P	D	D	M	D	D	0.758	D	D	D	0.860	0.647	0.867	1.373	T	D	D	D	D	D	3.550	24.900	0.997	D	D	0.567	5.599	0.479	4.974	1.000	0.718	0.522	0.571	0.550	.	4.720	4.720	7.905	1.026	0.599	1.000	0.056	0.111	620	SH2_domain	.	.	.	PTPN6	256	1	357	52	0.127139364303178	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01453	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	339	0	505	74	0.127806563039724	TRUE	TRUE
ENSG00000171262.11	.	BCM	GRCh38.p13	chr15	38484295	38484295	+	A	A	C	Missense_Mutation	SNP	ENST00000397609.6	exon8	c.A938C	p.N313T	exonic	ENSG00000171262.11	.	nonsynonymous SNV	ENSG00000171262.11:ENST00000397609.6:exon8:c.A938C:p.N313T	15q14	C3L-01453	.	.	.	.	.	.	.	.	.	3.16	T	T	.	.	N	N	.	T	N	0.110	T	T	D	0.232	0.526	0.493	0.127	T	.	T	T	T	D	1.979	19.100	0.978	D	N	-0.416	1.348	-0.273	1.620	0.778	0.707	0.644	0.725	0.567	.	3.770	2.530	0.525	1.210	0.750	0.988	0.992	0.996	892	.	.	.	.	FAM98B	298	0	505	67	0.117132867132867	TRUE	TRUE
ENSG00000137767.14	.	BCM	GRCh38.p13	chr15	45682497	45682497	+	C	C	G	Missense_Mutation	SNP	ENST00000260324.12	exon7	c.C884G	p.T295R	exonic	ENSG00000137767.14	.	nonsynonymous SNV	ENSG00000137767.14:ENST00000260324.12:exon7:c.C884G:p.T295R	15q21.1	C3L-01453	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	.	T	D	0.974	T	T	D	0.678	0.655	0.772	0.408	T	D	D	D	D	D	3.678	25.300	0.995	D	D	1.001	13.950	0.942	15.663	1.000	0.707	0.725	0.547	0.714	.	5.600	5.600	7.840	1.026	0.599	1.000	0.995	0.987	337	.	.	.	.	SQOR	176	0	264	47	0.15112540192926	TRUE	TRUE
ENSG00000177238.14	.	BCM	GRCh38.p13	chr16	31224318	31224318	+	G	G	A	Missense_Mutation	SNP	ENST00000322122.8	exon7	c.G997A	p.A333T	exonic	ENSG00000177238.14	.	nonsynonymous SNV	ENSG00000177238.14:ENST00000322122.8:exon7:c.G997A:p.A333T	16p11.2	C3L-01453	.	.	.	.	.	.	.	.	.	7.20	D	D	D	P	N	D	L	T	N	0.255	T	T	D	0.071	0.514	0.469	.	D	T	T	T	D	T	3.468	24.600	0.999	N	N	0.212	3.358	0.201	3.189	0.843	0.516	0.610	0.576	0.563	.	5.440	5.440	0.565	1.172	0.618	0.001	0.976	0.991	189	0.000	.	.	.	TRIM72	102	0	245	28	0.102564102564103	TRUE	TRUE
ENSG00000154118.13	.	BCM	GRCh38.p13	chr16	87644470	87644470	+	G	G	A	Missense_Mutation	SNP	ENST00000284262.3	exon2	c.G595A	p.V199M	exonic	ENSG00000154118.13	.	nonsynonymous SNV	ENSG00000154118.13:ENST00000284262.3:exon2:c.G595A:p.V199M	16q24.2	C3L-01453	0.0025	0.0291	0.0010	0.0001	0	3.138e-05	0	0.0001	rs9934067	3.19	T	T	B	B	D	N	N	T	N	0.160	T	T	.	0.057	.	0.110	0.134	T	T	T	T	T	D	2.346	21.800	0.988	D	N	-0.542	1.095	-0.334	1.497	0.999	0.718	0.547	0.571	0.568	.	5.030	3.030	3.657	1.146	-0.148	1.000	1.000	0.991	952	.	.	.	.	JPH3	358	0	728	118	0.139479905437352	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673803	7673803	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.C817T	p.R273C	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.C817T:p.R273C	17p13.1	C3L-01453	8.886e-06	0	0	0	0	1.605e-05	0	0	rs121913343	19.20	D	D	D	D	D	D	M	D	D	0.973	D	D	D	0.901	0.987	0.997	0.443	T	D	D	D	D	D	4.377	31	0.999	D	D	0.483	4.906	0.319	3.829	0.520	0.722	0.702	0.725	0.735	.	4.920	3.950	5.730	1.172	0.672	1.000	0.869	0.988	432	p53,_DNA-binding_domain	.	.	ID=COSV52662066;OCCURENCE=3(salivary_gland),68(breast),4(penis),23(liver),1(peritoneum),1(genital_tract),34(oesophagus),5(adrenal_gland),5(cervix),261(large_intestine),256(central_nervous_system),11(biliary_tract),10(vulva),2(pleura),46(ovary),13(bone),1(NS),55(stomach),59(haematopoietic_and_lymphoid_tissue),2(soft_tissue),8(kidney),20(urinary_tract),30(pancreas),13(skin),43(prostate),35(lung),11(thyroid),55(upper_aerodigestive_tract),1(testis),1(eye),7(small_intestine),49(endometrium)	TP53	605	0	800	146	0.154334038054968	TRUE	TRUE
ENSG00000017797.13	.	BCM	GRCh38.p13	chr18	9535734	9535734	+	G	G	A	Missense_Mutation	SNP	ENST00000383432.8	exon10	c.G1765A	p.V589M	exonic	ENSG00000017797.13	.	nonsynonymous SNV	ENSG00000017797.13:ENST00000383432.8:exon10:c.G1765A:p.V589M	18p11.22	C3L-01453	3.921e-05	0	0	0	0	3.559e-05	0	0.0001	rs780605304	9.20	D	D	P	B	D	D	N	T	N	0.689	T	T	T	0.214	.	0.287	0.852	D	D	T	T	T	D	2.854	23.100	0.997	D	D	0.395	4.314	0.423	4.525	1.000	0.732	0.725	0.744	0.714	.	5.010	4.130	9.273	1.100	0.592	1.000	0.873	0.073	627	.	.	.	.	RALBP1	215	0	420	58	0.121338912133891	TRUE	NA
ENSG00000141867.17	.	BCM	GRCh38.p13	chr19	15238385	15238385	+	G	G	A	Missense_Mutation	SNP	ENST00000263377.6	exon20	c.C4081T	p.L1361F	exonic	ENSG00000141867.17	.	nonsynonymous SNV	ENSG00000141867.17:ENST00000263377.6:exon20:c.C4081T:p.L1361F	19p13.12	C3L-01453	.	.	.	.	.	.	.	.	.	8.20	T	D	D	P	N	D	L	T	N	0.565	T	T	D	0.125	0.246	0.721	1.753	T	T	D	T	D	D	3.160	23.800	0.972	D	N	0.488	4.944	0.494	5.101	1.000	0.672	0.702	0.702	0.711	.	4.950	4.950	4.087	1.176	0.674	1.000	1.000	1.000	867	Bromodomain_protein_4,_C-terminal	.	.	ID=COSV99650932;OCCURENCE=3(skin)	BRD4	186	0	256	21	0.075812274368231	TRUE	TRUE
ENSG00000186115.13	.	BCM	GRCh38.p13	chr19	15878926	15878926	+	C	C	T	Missense_Mutation	SNP	ENST00000221700.11	exon13	c.G1408A	p.G470R	exonic	ENSG00000186115.13	.	nonsynonymous SNV	ENSG00000186115.13:ENST00000221700.11:exon13:c.G1408A:p.G470R	19p13.12	C3L-01453	7.495e-05	0	0	0	0	0	0	0.0006	rs146148233	18.20	D	D	D	D	U	D	H	D	D	0.704	D	D	D	0.757	0.987	0.974	0.730	T	D	D	D	D	D	3.379	24.300	0.995	D	D	0.420	4.469	0.150	2.948	0.000	0.554	0.588	0.574	0.564	.	2.620	1.550	5.285	0.910	0.501	1.000	0.044	0.027	976	Cytochrome_P450,_conserved_site	.	.	ID=COSV55616274;OCCURENCE=1(biliary_tract),3(stomach),1(endometrium)	CYP4F2	116	0	273	54	0.165137614678899	NA	TRUE
ENSG00000214046.8	.	BCM	GRCh38.p13	chr19	16659980	16659980	+	C	C	T	Missense_Mutation	SNP	ENST00000487416.6	exon2	c.G47A	p.G16E	exonic	ENSG00000214046.8;ENSG00000268790.5	.	nonsynonymous SNV	ENSG00000214046.8:ENST00000487416.6:exon2:c.G47A:p.G16E,ENSG00000268790.5:ENST00000593991.5:exon2:c.G41A:p.G14E	19p13.11	C3L-01453	.	.	.	.	.	.	.	.	rs956924929	13.18	D	D	D	P	U	D	.	.	D	0.947	T	T	D	0.746	0.498	0.304	0.161	D	T	D	D	D	D	4.059	27.400	0.996	D	D	0.564	5.575	0.571	5.873	1.000	0.442	0.522	0.522	0.562	.	4.850	4.850	4.461	0.947	0.599	0.999	0.781	0.939	759	.	.	.	.	SMIM7	361	0	701	84	0.107006369426752	TRUE	NA
ENSG00000100991.12	.	BCM	GRCh38.p13	chr20	35004547	35004547	+	G	G	T	Missense_Mutation	SNP	ENST00000252015.3	exon17	c.C1960A	p.R654S	exonic	ENSG00000100991.12	.	nonsynonymous SNV	ENSG00000100991.12:ENST00000252015.3:exon17:c.C1960A:p.R654S	20q11.22	C3L-01453	.	.	.	.	.	.	.	.	.	7.19	D	T	P	P	D	D	L	.	N	0.821	T	T	T	0.132	0.401	0.068	0.406	T	T	T	T	D	D	3.421	24.500	0.995	D	D	0.333	3.952	0.298	3.704	0.996	0.707	0.702	0.702	0.714	.	4.600	3.570	5.763	1.176	0.671	1.000	0.997	0.807	609	.	.	.	.	TRPC4AP	231	0	380	76	0.166666666666667	TRUE	TRUE
ENSG00000125975.14	.	BCM	GRCh38.p13	chr20	35528812	35528812	+	G	G	A	Missense_Mutation	SNP	ENST00000246199.5	exon2	c.C218T	p.S73L	exonic	ENSG00000125975.14	.	nonsynonymous SNV	ENSG00000125975.14:ENST00000246199.5:exon2:c.C218T:p.S73L	20q11.22	C3L-01453	.	.	.	.	.	.	.	.	rs1050191157	1.18	T	T	B	B	N	N	.	T	D	0.176	T	T	T	0.032	0.379	0.040	.	.	T	T	T	T	T	0.249	3.693	0.608	N	N	-1.603	0.054	-1.717	0.048	0.592	0.487	0.574	0.547	0.564	.	4.070	-7.570	-0.164	-0.975	-1.503	0.000	0.000	0.000	491	.	.	.	.	C20orf173	109	0	152	23	0.131428571428571	TRUE	NA
ENSG00000171587.15	.	BCM	GRCh38.p13	chr21	40013351	40013351	+	C	C	A	Missense_Mutation	SNP	ENST00000400454.6	exon33	c.G5722T	p.D1908Y	exonic	ENSG00000171587.15	.	nonsynonymous SNV	ENSG00000171587.15:ENST00000400454.6:exon33:c.G5722T:p.D1908Y	21q22.2	C3L-01453	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	N	0.867	T	T	D	0.471	0.492	0.938	1.543	D	T	D	D	D	D	4.033	27.200	0.996	D	D	0.667	6.685	0.698	7.718	1.000	0.487	0.574	0.574	0.564	.	5.390	5.390	7.370	0.966	0.530	1.000	1.000	0.999	968	.	.	.	.	DSCAM	69	0	113	14	0.110236220472441	TRUE	TRUE
ENSG00000133454.16	.	BCM	GRCh38.p13	chr22	25955334	25955334	+	G	G	C	Missense_Mutation	SNP	ENST00000335473.12	exon39	c.G6126C	p.E2042D	exonic	ENSG00000133454.16	.	nonsynonymous SNV	ENSG00000133454.16:ENST00000335473.12:exon39:c.G6126C:p.E2042D	22q12.1	C3L-01453	.	.	.	.	.	.	.	.	.	12.20	D	D	P	P	D	D	M	D	D	0.562	T	T	D	0.441	0.114	0.898	0.329	T	T	T	T	D	D	2.966	23.300	0.998	D	D	0.262	3.587	0.282	3.611	1.000	0.554	0.588	0.602	0.564	.	4.960	3.930	2.048	1.152	0.650	0.992	0.870	0.921	934	.	.	.	ID=COSV59129833;OCCURENCE=1(oesophagus)	MYO18B	106	0	193	54	0.218623481781377	TRUE	TRUE
ENSG00000090539.15	.	BCM	GRCh38.p13	chr3	184388996	184388996	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000090539.15	ENST00000204604.5:exon22:c.2812+1G>A	.	.	3q27.1	C3L-01453	4.444e-05	0.0001	0	0.0002	0	3.194e-05	0	0	rs767747110	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	4.753	32	0.919	D	.	0.600	5.921	0.363	4.104	0.723	0.056	0.060	0.072	0.075	0.364	4.930	4.050	3.881	1.175	0.676	1.000	0.740	0.124	911	.	.	.	ID=COSV52609935;OCCURENCE=1(stomach),1(haematopoietic_and_lymphoid_tissue)	CHRD	92	0	187	30	0.138248847926267	TRUE	TRUE
ENSG00000117385.16	.	BCM	GRCh38.p13	chr1	42766792	42766792	+	C	C	T	Silent	SNP	ENST00000296388.10	exon1	c.G180A	p.R60R	exonic	ENSG00000117385.16	.	synonymous SNV	ENSG00000117385.16:ENST00000296388.10:exon1:c.G180A:p.R60R	1p34.2	C3L-01453	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	P3H1	292	0	444	58	0.115537848605578	TRUE	TRUE
ENSG00000115207.13	.	BCM	GRCh38.p13	chr2	27336404	27336404	+	A	A	G	Silent	SNP	ENST00000359541.6	exon8	c.T1149C	p.H383H	exonic	ENSG00000115207.13	.	synonymous SNV	ENSG00000115207.13:ENST00000359541.6:exon8:c.T1149C:p.H383H	2p23.3	C3L-01453	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GTF3C2	145	0	264	45	0.145631067961165	TRUE	TRUE
ENSG00000114270.17	.	BCM	GRCh38.p13	chr3	48570942	48570942	+	G	G	A	Silent	SNP	ENST00000328333.12	exon94	c.C7191T	p.P2397P	exonic	ENSG00000114270.17	.	synonymous SNV	ENSG00000114270.17:ENST00000328333.12:exon94:c.C7191T:p.P2397P	3p21.31	C3L-01453	0.0002	0	0.0002	0	0	0.0003	0	0	rs34360255	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL7A1	327	0	524	93	0.150729335494327	TRUE	NA
ENSG00000175426.11	.	BCM	GRCh38.p13	chr5	96423385	96423385	+	C	C	T	Silent	SNP	ENST00000311106.8	exon4	c.G471A	p.T157T	exonic	ENSG00000175426.11	.	synonymous SNV	ENSG00000175426.11:ENST00000311106.8:exon4:c.G471A:p.T157T	5q15	C3L-01453	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCSK1	681	0	1036	154	0.129411764705882	TRUE	NA
ENSG00000019991.18	.	BCM	GRCh38.p13	chr7	81707328	81707328	+	C	C	T	Silent	SNP	ENST00000222390.11	exon14	c.G1578A	p.E526E	exonic	ENSG00000019991.18	.	synonymous SNV	ENSG00000019991.18:ENST00000222390.11:exon14:c.G1578A:p.E526E	7q21.11	C3L-01453	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HGF	336	0	460	79	0.146567717996289	TRUE	TRUE
ENSG00000161996.19	.	BCM	GRCh38.p13	chr16	656737	656737	+	C	C	T	Silent	SNP	ENST00000293879.9	exon19	c.C2208T	p.Y736Y	exonic	ENSG00000161996.19	.	synonymous SNV	ENSG00000161996.19:ENST00000293879.9:exon19:c.C2208T:p.Y736Y	16p13.3	C3L-01453	8.465e-06	0.0001	0	0	0	0	0	0	rs372511115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WDR90	98	0	148	26	0.149425287356322	TRUE	NA
ENSG00000103091.15	.	BCM	GRCh38.p13	chr16	74915915	74915915	+	C	C	T	Silent	SNP	ENST00000262144.11	exon13	c.G1179A	p.Q393Q	exonic	ENSG00000103091.15	.	synonymous SNV	ENSG00000103091.15:ENST00000262144.11:exon13:c.G1179A:p.Q393Q	16q23.1	C3L-01453	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WDR59	306	0	467	65	0.12218045112782	TRUE	TRUE
ENSG00000141526.16	.	BCM	GRCh38.p13	chr17	82237334	82237334	+	C	C	T	Silent	SNP	ENST00000581287.5	exon3	c.C564T	p.L188L	exonic	ENSG00000141526.16	.	synonymous SNV	ENSG00000141526.16:ENST00000581287.5:exon3:c.C564T:p.L188L	17q25.3	C3L-01453	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66429952;OCCURENCE=1(biliary_tract)	SLC16A3	48	0	143	17	0.10625	TRUE	TRUE
ENSG00000065717.15	.	BCM	GRCh38.p13	chr19	3019329	3019329	+	C	C	T	Silent	SNP	ENST00000262953.11	exon7	c.G504A	p.A168A	exonic	ENSG00000065717.15	.	synonymous SNV	ENSG00000065717.15:ENST00000262953.11:exon7:c.G504A:p.A168A	19p13.3	C3L-01453	9.75e-05	0	0	0	0	0	0	0.0004	rs781758361	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TLE2	226	0	582	56	0.0877742946708464	TRUE	NA
ENSG00000011590.14	.	BCM	GRCh38.p13	chr19	35714728	35714728	+	C	C	T	Silent	SNP	ENST00000392197.7	exon3	c.C102T	p.T34T	exonic	ENSG00000011590.14	.	synonymous SNV	ENSG00000011590.14:ENST00000392197.7:exon3:c.C102T:p.T34T	19q13.12	C3L-01453	.	.	.	.	.	.	.	.	rs267605432	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZBTB32	125	0	327	38	0.104109589041096	TRUE	NA
ENSG00000069020.18	.	BCM	GRCh38.p13	chr5	66828847	66828847	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000069020.18	.	.	.	5q12.3	C3L-01453	.	.	.	.	.	.	.	.	rs914001649	8.16	T	D	D	D	.	D	.	T	N	0.614	T	T	D	0.196	0.248	0.800	.	.	.	T	T	D	T	2.243	21.200	0.997	D	D	0.684	6.902	0.720	8.143	1.000	0.598	0.596	0.159	0.562	.	5.260	5.260	8.135	1.176	0.618	1.000	1.000	0.999	876	.	.	.	.	MAST4	224	0	374	41	0.0987951807228916	TRUE	NA
ENSG00000103507.14	.	BCM	GRCh38.p13	chr16	31112403	31112403	+	T	T	C	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000103507.14	ENST00000219794.11:c.*138T>C	.	.	16p11.2	C3L-01453	.	.	.	.	.	.	.	.	rs553418699	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BCKDK	163	0	279	42	0.130841121495327	TRUE	NA
ENSG00000196581.11	.	BCM	GRCh38.p13	chr1	4772524	4772524	+	C	C	T	Nonsense_Mutation	SNP	ENST00000378191.5	exon4	c.C1162T	p.R388X	exonic	ENSG00000196581.11	.	stopgain	ENSG00000196581.11:ENST00000378191.5:exon4:c.C1162T:p.R388X	1p36.32	C3L-03635	.	.	.	.	.	.	.	.	.	6.6	.	.	.	.	D	A	.	.	.	0.829	.	.	.	.	.	.	.	.	.	D	D	.	.	8.417	43	0.996	D	D	0.499	5.030	0.303	3.736	0.319	0.701	0.574	0.717	0.564	.	5.120	1.660	2.726	1.026	0.599	1.000	0.959	0.683	988	AJAP1/PANP,_C-terminal	.	.	ID=COSV65452928;OCCURENCE=1(ovary),1(thyroid)	AJAP1	134	1	189	14	0.0689655172413793	TRUE	TRUE
ENSG00000000971.16	.	BCM	GRCh38.p13	chr1	196747129	196747129	+	G	G	A	Missense_Mutation	SNP	ENST00000367429.9	exon22	c.G3512A	p.R1171Q	exonic	ENSG00000000971.16	.	nonsynonymous SNV	ENSG00000000971.16:ENST00000367429.9:exon22:c.G3512A:p.R1171Q	1q31.3	C3L-03635	.	.	.	.	.	.	.	.	.	4.15	D	D	.	.	.	N	.	D	N	0.044	T	T	D	0.173	0.617	0.442	1.467	T	.	T	T	T	T	0.240	3.589	0.844	N	N	-1.666	0.042	-1.538	0.094	0.000	0.693	0.588	0.545	0.564	.	4.480	0.821	0.382	-0.975	-1.758	0.035	0.000	0.001	534	.	.	.	ID=COSV66406620;OCCURENCE=1(NS),1(skin)	CFH	296	1	384	39	0.0921985815602837	NA	TRUE
ENSG00000218819.6	.	BCM	GRCh38.p13	chr2	21141270	21141270	+	A	A	G	Missense_Mutation	SNP	ENST00000405799.3	exon4	c.A3803G	p.N1268S	exonic	ENSG00000218819.6	.	nonsynonymous SNV	ENSG00000218819.6:ENST00000405799.3:exon4:c.A3803G:p.N1268S	2p24.1	C3L-03635	.	.	.	.	.	.	.	.	.	0.14	T	T	.	.	.	.	.	T	N	0.044	T	T	T	0.016	0.185	0.088	.	.	T	T	T	T	T	-0.018	1.225	0.317	N	N	-0.834	0.607	-0.934	0.575	0.000	0.487	0.574	0.574	0.564	.	4.180	-0.913	1.123	0.300	-0.070	0.009	0.710	0.426	690	.	.	.	.	TDRD15	82	0	153	10	0.0613496932515337	TRUE	TRUE
ENSG00000115275.14	.	BCM	GRCh38.p13	chr2	74462786	74462786	+	C	C	A	Missense_Mutation	SNP	ENST00000448666.7	exon4	c.G1003T	p.V335L	exonic	ENSG00000115275.14	.	nonsynonymous SNV	ENSG00000115275.14:ENST00000448666.7:exon4:c.G1003T:p.V335L	2p13.1	C3L-03635	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	N	T	N	0.083	T	T	T	0.063	0.567	0.349	0.242	T	T	T	T	T	D	1.373	14.900	0.961	D	N	-0.486	1.205	-0.279	1.607	1.000	0.672	0.698	0.702	0.711	.	4.730	3.850	1.034	0.103	0.599	0.982	0.994	0.926	506	.	.	.	.	MOGS	655	0	1043	71	0.0637342908438061	NA	TRUE
ENSG00000072163.19	.	BCM	GRCh38.p13	chr2	127654537	127654537	+	G	G	T	Missense_Mutation	SNP	ENST00000355119.8	exon4	c.C246A	p.F82L	exonic	ENSG00000072163.19	.	nonsynonymous SNV	ENSG00000072163.19:ENST00000355119.8:exon4:c.C246A:p.F82L	2q14.3	C3L-03635	.	.	.	.	.	.	.	.	.	15.20	D	D	B	B	D	D	L	D	D	0.843	T	T	D	0.573	0.512	0.777	0.226	D	D	D	D	D	D	2.784	23.000	0.995	D	D	-0.242	1.763	-0.115	2.006	1.000	0.707	0.590	0.616	0.714	.	5.370	3.490	4.623	-0.102	0.676	1.000	0.828	0.648	946	Zinc_finger,_LIM-type	.	.	.	LIMS2	182	0	372	44	0.105769230769231	TRUE	TRUE
ENSG00000172318.5	.	BCM	GRCh38.p13	chr2	167869714	167869714	+	T	T	G	Missense_Mutation	SNP	ENST00000392690.3	exon1	c.T675G	p.D225E	exonic	ENSG00000172318.5	.	nonsynonymous SNV	ENSG00000172318.5:ENST00000392690.3:exon1:c.T675G:p.D225E	2q24.3	C3L-03635	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	N	T	N	0.274	T	T	T	0.087	0.413	0.432	0.443	T	T	T	T	T	D	1.588	16.300	0.791	D	N	-0.507	1.163	-0.198	1.791	0.853	0.732	0.574	0.744	0.564	.	6.020	4.850	1.903	1.138	0.665	1.000	1.000	1.000	753	.	.	.	.	B3GALT1	82	0	158	38	0.193877551020408	TRUE	TRUE
ENSG00000118997.14	.	BCM	GRCh38.p13	chr2	195808819	195808819	+	A	A	C	Missense_Mutation	SNP	ENST00000312428.11	exon53	c.T9946G	p.Y3316D	exonic	ENSG00000118997.14	.	nonsynonymous SNV	ENSG00000118997.14:ENST00000312428.11:exon53:c.T9946G:p.Y3316D	2q32.3	C3L-03635	.	.	.	.	.	.	.	.	.	2.19	T	.	B	B	N	N	L	D	N	0.265	T	T	T	0.193	0.475	0.118	0.042	T	T	T	T	T	D	0.532	6.840	0.930	N	N	-1.089	0.316	-1.077	0.400	0.034	0.500	0.574	0.492	0.504	.	5.060	-4.470	-0.687	-1.000	-0.870	0.000	0.782	0.958	900	.	.	.	.	DNAH7	244	0	351	28	0.0738786279683377	TRUE	TRUE
ENSG00000183662.11	.	BCM	GRCh38.p13	chr3	68006643	68006643	+	C	C	T	Missense_Mutation	SNP	ENST00000478136.6	exon2	c.C17T	p.A6V	exonic	ENSG00000183662.11	.	nonsynonymous SNV	ENSG00000183662.11:ENST00000478136.6:exon2:c.C17T:p.A6V	3p14.1	C3L-03635	.	.	.	.	.	.	.	.	.	4.19	T	T	P	B	N	D	N	.	N	0.603	T	T	T	0.186	0.243	0.151	0.506	T	T	T	T	D	T	2.616	22.700	0.991	D	D	0.079	2.806	0.310	3.774	1.000	0.487	0.574	0.563	0.564	.	6.170	6.170	6.472	1.026	0.599	1.000	1.000	0.996	960	.	.	.	.	TAFA1	181	0	356	34	0.0871794871794872	TRUE	TRUE
ENSG00000174953.14	.	BCM	GRCh38.p13	chr3	154303399	154303399	+	T	T	C	Missense_Mutation	SNP	ENST00000496811.6	exon9	c.A1147G	p.M383V	exonic	ENSG00000174953.14	.	nonsynonymous SNV	ENSG00000174953.14:ENST00000496811.6:exon9:c.A1147G:p.M383V	3q25.2	C3L-03635	5.802e-05	0	0	0	0	0.0001	0	0	rs754937391	4.20	T	T	B	B	D	D	N	T	N	0.692	T	T	T	0.240	.	0.590	0.301	T	T	T	T	T	T	2.380	22.000	0.936	D	D	-0.183	1.924	0.084	2.669	1.000	0.732	0.744	0.725	0.728	.	5.530	5.530	7.208	1.138	0.665	1.000	1.000	0.999	875	Helicase_superfamily_1/2,_ATP-binding_domain	.	.	ID=COSV57674533;OCCURENCE=1(pancreas)	DHX36	63	0	133	11	0.0763888888888889	TRUE	TRUE
ENSG00000174776.11	.	BCM	GRCh38.p13	chr3	167531207	167531207	+	G	G	A	Missense_Mutation	SNP	ENST00000308378.7	exon9	c.C1070T	p.T357M	exonic	ENSG00000174776.11	.	nonsynonymous SNV	ENSG00000174776.11:ENST00000308378.7:exon9:c.C1070T:p.T357M	3q26.1	C3L-03635	0.0001	0.0009	0	0.0001	0	7.51e-05	0.0011	0	rs151083851	0.20	T	T	B	B	N	N	L	T	N	0.155	T	T	T	0.022	.	0.259	0.030	T	T	T	T	T	T	-0.562	0.088	0.719	N	N	-1.598	0.055	-1.665	0.059	0.001	0.487	0.574	0.574	0.564	.	5.360	-5.110	-0.065	-1.022	-1.238	0.000	0.000	0.000	881	WD40-repeat-containing_domain	.	.	ID=COSV57710516;OCCURENCE=1(oesophagus)	WDR49	298	1	497	87	0.148972602739726	NA	TRUE
ENSG00000152969.20	.	BCM	GRCh38.p13	chr4	6062329	6062329	+	C	C	T	Missense_Mutation	SNP	ENST00000282924.9	exon10	c.G1543A	p.A515T	exonic	ENSG00000152969.20	.	nonsynonymous SNV	ENSG00000152969.20:ENST00000282924.9:exon10:c.G1543A:p.A515T	4p16.1	C3L-03635	.	.	.	.	.	.	.	.	rs1023704574	15.20	D	D	D	D	D	D	M	T	D	0.853	T	T	T	0.251	0.106	0.590	1.576	D	T	D	D	D	D	3.626	25.100	0.999	D	D	0.451	4.677	0.322	3.850	1.000	0.615	0.654	0.659	0.564	.	4.850	4.850	5.684	1.026	0.599	1.000	0.031	0.019	988	Janus_kinase_and_microtubule-interacting_protein,_C-terminal_domain	.	.	ID=COSV51534944;OCCURENCE=1(large_intestine)	JAKMIP1	539	0	877	61	0.0650319829424307	TRUE	TRUE
ENSG00000182308.7	.	BCM	GRCh38.p13	chr4	41982163	41982163	+	A	A	G	Missense_Mutation	SNP	ENST00000333141.7	exon1	c.A371G	p.N124S	exonic	ENSG00000182308.7	.	nonsynonymous SNV	ENSG00000182308.7:ENST00000333141.7:exon1:c.A371G:p.N124S	4p13	C3L-03635	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	D	D	L	T	D	0.380	T	T	T	0.310	0.648	0.255	0.832	T	T	T	T	D	D	1.677	16.880	0.965	D	N	0.122	2.975	-0.061	2.163	0.981	0.487	0.574	0.547	0.542	.	0.688	0.688	3.589	0.484	0.407	1.000	0.218	0.625	599	.	.	.	.	DCAF4L1	146	0	311	30	0.0879765395894428	TRUE	TRUE
ENSG00000196159.12	.	BCM	GRCh38.p13	chr4	125468791	125468791	+	A	A	C	Missense_Mutation	SNP	ENST00000674496.1	exon11	c.A12179C	p.H4060P	exonic	ENSG00000196159.12	.	nonsynonymous SNV	ENSG00000196159.12:ENST00000674496.1:exon11:c.A12179C:p.H4060P	4q28.1	C3L-03635	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	U	D	H	D	D	0.991	D	D	D	0.942	0.746	0.905	0.237	T	D	D	D	D	D	4.004	27.000	0.982	D	D	0.884	10.651	0.821	10.760	1.000	0.707	0.574	0.653	0.714	.	5.310	5.310	9.133	1.308	0.684	1.000	0.999	0.973	923	Laminin_G_domain	.	.	.	FAT4	133	0	154	15	0.0887573964497041	TRUE	TRUE
ENSG00000112902.12	.	BCM	GRCh38.p13	chr5	9119008	9119008	+	G	G	A	Missense_Mutation	SNP	ENST00000382496.10	exon15	c.C1915T	p.R639C	exonic	ENSG00000112902.12	.	nonsynonymous SNV	ENSG00000112902.12:ENST00000382496.10:exon15:c.C1915T:p.R639C	5p15.31	C3L-03635	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	L	T	D	0.846	T	T	D	0.597	0.700	0.774	1.247	D	T	D	D	D	D	4.383	31	0.999	D	D	0.644	6.399	0.579	5.976	1.000	0.539	0.588	0.607	0.564	.	5.430	4.540	3.128	0.161	0.676	1.000	0.996	0.993	925	.	.	.	ID=COSV101228520;OCCURENCE=1(central_nervous_system),1(endometrium)	SEMA5A	166	0	297	26	0.0804953560371517	TRUE	TRUE
ENSG00000113100.10	.	BCM	GRCh38.p13	chr5	26988188	26988188	+	C	C	T	Missense_Mutation	SNP	ENST00000231021.9	exon2	c.G146A	p.R49H	exonic	ENSG00000113100.10	.	nonsynonymous SNV	ENSG00000113100.10:ENST00000231021.9:exon2:c.G146A:p.R49H	5p14.1	C3L-03635	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.081	T	T	T	0.106	0.479	0.283	0.524	T	T	T	T	T	T	1.161	13.320	0.360	N	N	-0.904	0.515	-0.793	0.767	0.000	0.554	0.574	0.618	0.564	.	5.640	-1.850	0.194	-0.669	0.549	0.975	0.905	0.996	891	.	.	.	ID=COSV50289480;OCCURENCE=1(large_intestine)	CDH9	399	0	602	32	0.0504731861198738	TRUE	NA
ENSG00000113209.9	.	BCM	GRCh38.p13	chr5	141136566	141136566	+	G	G	A	Missense_Mutation	SNP	ENST00000231134.8	exon1	c.G1132A	p.G378S	exonic	ENSG00000113209.9	.	nonsynonymous SNV	ENSG00000113209.9:ENST00000231134.8:exon1:c.G1132A:p.G378S	5q31.3	C3L-03635	8.238e-06	0	0	0	0	1.498e-05	0	0	rs782760735	7.14	D	D	.	.	.	N	.	T	D	0.654	D	T	D	0.246	0.672	0.643	0.665	T	.	T	T	D	.	3.515	24.800	0.998	D	N	0.604	5.969	0.464	4.847	0.954	0.660	0.547	0.663	0.621	.	4.950	4.950	2.889	1.101	0.590	1.000	0.842	0.604	549	.	.	.	ID=COSV50678024;OCCURENCE=1(large_intestine),1(skin)	PCDHB5	237	0	336	33	0.0894308943089431	TRUE	TRUE
ENSG00000151914.20	.	BCM	GRCh38.p13	chr6	56597910	56597910	+	T	T	C	Missense_Mutation	SNP	ENST00000361203.7	exon43	c.A11392G	p.T3798A	exonic	ENSG00000151914.20	.	nonsynonymous SNV	ENSG00000151914.20:ENST00000361203.7:exon43:c.A11392G:p.T3798A	6p12.1	C3L-03635	.	.	.	.	.	.	.	.	.	0.17	T	.	B	B	N	.	.	T	N	0.167	T	T	T	0.052	.	0.569	0.116	T	T	T	T	T	T	-0.069	0.962	0.558	N	N	-1.141	0.271	-1.134	0.342	0.776	0.707	0.725	0.725	0.714	.	5.770	-1.140	0.266	1.118	0.665	0.000	0.271	0.217	247	.	.	.	.	DST	182	0	283	20	0.066006600660066	TRUE	TRUE
ENSG00000079841.18	.	BCM	GRCh38.p13	chr6	72274420	72274420	+	C	C	T	Missense_Mutation	SNP	ENST00000521978.5	exon23	c.C3470T	p.P1157L	exonic	ENSG00000079841.18	.	nonsynonymous SNV	ENSG00000079841.18:ENST00000521978.5:exon23:c.C3470T:p.P1157L	6q13	C3L-03635	0.0214	0.0067	0.0163	0.0001	0.0075	0.0321	0.0161	0.0069	rs41265501	11.19	D	D	D	D	D	D	M	T	D	0.670	T	T	.	0.247	.	.	0.635	T	T	T	T	T	D	3.466	24.600	0.996	D	D	0.538	5.345	0.605	6.293	1.000	0.500	0.624	0.574	0.613	.	5.560	5.560	6.947	1.026	0.599	1.000	0.998	0.988	901	.	.	.	ID=COSV53450187;OCCURENCE=1(skin)	RIMS1	115	0	301	31	0.0933734939759036	TRUE	TRUE
ENSG00000146530.14	.	BCM	GRCh38.p13	chr7	12337000	12337000	+	G	G	A	Nonsense_Mutation	SNP	ENST00000275358.8	exon26	c.C4546T	p.R1516X	exonic	ENSG00000146530.14	.	stopgain	ENSG00000146530.14:ENST00000275358.8:exon26:c.C4546T:p.R1516X	7p21.3	C3L-03635	.	.	.	.	.	.	.	.	rs113354784	3.6	.	.	.	.	N	A	.	.	.	0.194	.	.	.	.	.	.	.	.	.	D	D	.	.	8.516	43	0.991	N	N	-0.095	2.191	-0.422	1.334	0.927	0.722	0.574	0.699	0.621	.	4.630	-0.844	0.428	0.131	-0.154	0.001	0.581	0.751	853	EGF-like_domain	.	.	.	VWDE	78	1	170	52	0.234234234234234	TRUE	NA
ENSG00000184408.10	.	BCM	GRCh38.p13	chr7	120275485	120275485	+	G	G	A	Missense_Mutation	SNP	ENST00000331113.9	exon1	c.G853A	p.V285I	exonic	ENSG00000184408.10	.	nonsynonymous SNV	ENSG00000184408.10:ENST00000331113.9:exon1:c.G853A:p.V285I	7q31.31	C3L-03635	.	.	.	.	.	.	.	.	.	12.20	T	T	P	B	D	D	L	D	N	0.298	D	D	D	0.533	0.613	0.758	2.237	T	T	D	D	D	D	2.740	22.900	0.995	D	D	0.358	4.094	0.452	4.749	1.000	0.660	0.663	0.663	0.542	.	5.180	5.180	10.003	1.172	0.672	1.000	0.993	0.978	672	Ion_transport_domain	.	.	ID=COSV58580353;OCCURENCE=3(large_intestine),1(haematopoietic_and_lymphoid_tissue),1(pancreas)	KCND2	117	0	174	10	0.0543478260869565	TRUE	TRUE
ENSG00000213203.3	.	BCM	GRCh38.p13	chr7	150720902	150720902	+	G	G	A	Missense_Mutation	SNP	ENST00000307194.6	exon3	c.G898A	p.V300I	exonic	ENSG00000213203.3	.	nonsynonymous SNV	ENSG00000213203.3:ENST00000307194.6:exon3:c.G898A:p.V300I	7q36.1	C3L-03635	0	0	0	0	0	0	0	0	rs752300708	0.19	T	T	B	B	U	N	N	T	N	0.075	T	T	T	0.022	0.138	0.134	0.552	.	T	T	T	T	T	-1.528	0.001	0.703	N	N	-2.142	0.004	-2.268	0.003	1.000	0.707	0.634	0.590	0.714	.	3.390	-6.780	-1.630	-1.806	-1.478	0.000	0.000	0.000	774	.	.	.	ID=COSV56188181;OCCURENCE=1(large_intestine)	GIMAP1	122	0	188	15	0.0738916256157636	TRUE	TRUE
ENSG00000182674.6	.	BCM	GRCh38.p13	chr8	72937223	72937223	+	C	C	T	Missense_Mutation	SNP	ENST00000523207.2	exon3	c.C1868T	p.P623L	exonic	ENSG00000182674.6	.	nonsynonymous SNV	ENSG00000182674.6:ENST00000523207.2:exon3:c.C1868T:p.P623L	8q21.11	C3L-03635	.	.	.	.	.	.	.	.	rs370327292	3.20	D	T	B	B	N	D	L	T	N	0.125	T	T	T	0.056	.	0.357	0.610	T	T	T	T	T	T	1.278	14.230	0.953	D	N	-0.203	1.869	-0.094	2.065	0.568	0.487	0.547	0.547	0.564	.	5.040	5.040	2.064	1.026	0.549	0.137	0.060	0.018	848	.	.	.	ID=COSV101578828;OCCURENCE=1(stomach)	KCNB2	289	0	627	56	0.08199121522694	TRUE	TRUE
ENSG00000104447.12	.	BCM	GRCh38.p13	chr8	115414023	115414023	+	T	T	G	Nonstop_Mutation	SNP	ENST00000640765.1	exon6	c.A3846C	p.X1282Y	exonic	ENSG00000104447.12	.	stoploss	ENSG00000104447.12:ENST00000640765.1:exon6:c.A3846C:p.X1282Y	8q23.3	C3L-03635	.	.	.	.	.	.	.	.	.	1.4	.	.	.	.	.	N	.	.	.	0.589	.	.	.	.	.	.	.	.	.	T	T	.	.	1.499	15.730	0.836	D	.	1.010	14.236	0.857	12.020	1.000	0.201	0.097	0.060	0.402	0.947	5.430	5.430	3.122	1.138	0.665	1.000	1.000	1.000	935	.	.	.	.	TRPS1	118	0	205	17	0.0765765765765766	TRUE	TRUE
ENSG00000160886.13	.	BCM	GRCh38.p13	chr8	142701639	142701639	+	G	G	A	Missense_Mutation	SNP	ENST00000292430.10	exon2	c.G143A	p.R48K	exonic	ENSG00000160886.13	.	nonsynonymous SNV	ENSG00000160886.13:ENST00000292430.10:exon2:c.G143A:p.R48K	8q24.3	C3L-03635	.	.	.	.	.	.	.	.	.	1.20	D	T	B	B	N	N	N	T	N	0.138	T	T	T	0.003	0.302	0.014	0.078	T	T	T	T	T	T	-1.348	0.001	0.835	N	N	-1.801	0.023	-1.900	0.022	1.000	0.706	0.660	0.576	0.613	.	2.060	-4.110	-3.938	-0.825	-0.980	0.000	0.048	0.021	988	.	.	.	ID=COSV99456086;OCCURENCE=1(skin)	LY6K	214	0	395	111	0.219367588932806	TRUE	TRUE
ENSG00000148541.13	.	BCM	GRCh38.p13	chr10	59262534	59262534	+	G	G	A	Missense_Mutation	SNP	ENST00000618804.5	exon10	c.C1136T	p.A379V	exonic	ENSG00000148541.13	.	nonsynonymous SNV	ENSG00000148541.13:ENST00000618804.5:exon10:c.C1136T:p.A379V	10q21.1	C3L-03635	7.427e-05	0	0	0	0	0.0001	0	6.057e-05	rs200879419	2.20	T	T	B	B	N	D	N	T	N	0.123	T	T	T	0.185	.	0.639	.	T	T	T	T	T	T	0.878	10.210	0.207	D	N	-0.935	0.477	-0.745	0.835	0.330	0.554	0.588	0.574	0.564	.	5.930	1.790	1.391	-0.485	-0.105	0.967	0.026	0.103	982	.	.	.	ID=COSV99514923;OCCURENCE=1(stomach)	FAM13C	436	1	748	60	0.0742574257425743	TRUE	NA
ENSG00000171219.9	.	BCM	GRCh38.p13	chr11	64834878	64834878	+	C	C	T	Missense_Mutation	SNP	ENST00000342711.6	exon18	c.G2146A	p.G716S	exonic	ENSG00000171219.9	.	nonsynonymous SNV	ENSG00000171219.9:ENST00000342711.6:exon18:c.G2146A:p.G716S	11q13.1	C3L-03635	.	.	.	.	.	.	.	.	.	7.20	T	T	D	D	D	D	M	T	N	0.632	T	T	T	0.160	0.224	0.498	0.870	T	T	T	T	D	T	3.132	23.700	0.998	D	N	0.357	4.089	0.383	4.238	1.000	0.696	0.588	0.723	0.568	.	5.070	5.070	0.367	1.026	0.599	0.390	0.954	0.806	309	.	.	.	.	CDC42BPG	216	0	356	64	0.152380952380952	TRUE	TRUE
ENSG00000111241.2	.	BCM	GRCh38.p13	chr12	4434280	4434280	+	G	G	A	Missense_Mutation	SNP	ENST00000228837.2	exon3	c.C562T	p.R188W	exonic	ENSG00000111241.2	.	nonsynonymous SNV	ENSG00000111241.2:ENST00000228837.2:exon3:c.C562T:p.R188W	12p13.32	C3L-03635	9.884e-05	9.61e-05	8.637e-05	0.0002	0.0002	8.99e-05	0	6.056e-05	rs142642694	15.20	D	D	D	D	D	D	M	T	D	0.867	T	T	D	0.571	.	0.752	0.834	T	D	T	D	D	D	3.880	26.200	0.999	D	D	0.653	6.514	0.556	5.708	1.000	0.487	0.574	0.547	0.564	.	5.130	4.230	3.458	1.176	0.676	1.000	0.998	0.955	870	.	.	.	ID=COSV57403529;OCCURENCE=2(breast),1(large_intestine),1(central_nervous_system),1(endometrium)	FGF6	288	0	504	134	0.210031347962382	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-03635	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	268	0	479	69	0.125912408759124	TRUE	TRUE
ENSG00000179104.9	.	BCM	GRCh38.p13	chr12	82985940	82985940	+	G	G	A	Missense_Mutation	SNP	ENST00000321196.8	exon8	c.G1964A	p.R655H	exonic	ENSG00000179104.9	.	nonsynonymous SNV	ENSG00000179104.9:ENST00000321196.8:exon8:c.G1964A:p.R655H	12q21.31	C3L-03635	8.245e-05	0	0.0002	0.0005	0	6.001e-05	0	0	rs779280970	14.20	D	D	D	D	D	D	M	T	N	0.720	D	D	D	0.472	.	0.734	0.721	T	T	T	D	T	D	4.118	27.900	0.999	D	D	0.783	8.461	0.724	8.235	1.000	0.638	0.588	0.653	0.655	.	5.400	5.400	9.139	1.176	0.676	1.000	0.664	0.232	898	Tetratricopeptide_repeat-containing_domain	.	.	.	TMTC2	115	0	203	19	0.0855855855855856	TRUE	NA
ENSG00000185344.14	.	BCM	GRCh38.p13	chr12	123757971	123757971	+	T	T	A	Missense_Mutation	SNP	ENST00000330342.8	exon20	c.T2510A	p.F837Y	exonic	ENSG00000185344.14	.	nonsynonymous SNV	ENSG00000185344.14:ENST00000330342.8:exon20:c.T2510A:p.F837Y	12q24.31	C3L-03635	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	.	D	N	0.795	D	D	D	0.792	0.716	0.760	0.622	T	T	D	D	D	D	4.163	28.300	0.996	D	D	0.805	8.883	0.795	9.970	1.000	0.732	0.710	0.725	0.728	.	5.710	5.710	8.017	1.131	0.661	1.000	1.000	0.999	342	.	.	.	.	ATP6V0A2	208	0	315	56	0.150943396226415	TRUE	TRUE
ENSG00000132970.14	.	BCM	GRCh38.p13	chr13	26642386	26642386	+	G	G	A	Missense_Mutation	SNP	ENST00000335327.6	exon3	c.G116A	p.R39H	exonic	ENSG00000132970.14	.	nonsynonymous SNV	ENSG00000132970.14:ENST00000335327.6:exon3:c.G116A:p.R39H	13q12.13	C3L-03635	4.959e-05	0.0003	0.0003	0	0	0	0	0	rs774059020	15.20	D	D	D	B	D	D	M	T	D	0.926	D	T	D	0.559	.	0.454	1.187	D	T	T	D	D	D	3.742	25.600	0.999	D	D	0.789	8.559	0.770	9.300	1.000	0.706	0.574	0.710	0.714	.	5.550	4.690	7.602	1.176	0.676	1.000	0.999	0.986	915	.	.	.	ID=COSV58963075;OCCURENCE=1(large_intestine)	WASF3	79	0	185	26	0.123222748815166	TRUE	TRUE
ENSG00000102531.16	.	BCM	GRCh38.p13	chr13	49167258	49167258	+	A	A	G	Missense_Mutation	SNP	ENST00000492622.6	exon9	c.A992G	p.N331S	exonic	ENSG00000102531.16	.	nonsynonymous SNV	ENSG00000102531.16:ENST00000492622.6:exon9:c.A992G:p.N331S	13q14.2	C3L-03635	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.106	T	T	T	0.075	0.319	0.252	0.170	T	T	T	T	T	T	0.785	9.246	0.248	N	N	-1.097	0.309	-0.848	0.691	0.802	0.732	0.744	0.651	0.728	.	5.190	2.260	0.571	-0.615	-0.801	1.000	0.377	0.767	556	Fibronectin_type_III	.	.	.	FNDC3A	109	0	205	13	0.0596330275229358	TRUE	TRUE
ENSG00000100813.14	.	BCM	GRCh38.p13	chr14	23061571	23061571	+	C	C	G	Missense_Mutation	SNP	ENST00000262710.5	exon17	c.G3325C	p.E1109Q	exonic	ENSG00000100813.14	.	nonsynonymous SNV	ENSG00000100813.14:ENST00000262710.5:exon17:c.G3325C:p.E1109Q	14q11.2	C3L-03635	.	.	.	.	.	.	.	.	.	6.20	D	T	B	B	D	D	L	T	N	0.368	T	T	T	0.041	0.155	0.355	1.105	T	T	T	T	D	D	2.982	23.400	0.997	D	N	-0.073	2.263	0.100	2.736	1.000	0.722	0.702	0.702	0.735	.	4.790	4.790	2.602	1.018	0.589	1.000	0.991	0.984	825	.	.	.	.	ACIN1	82	0	152	12	0.0731707317073171	TRUE	TRUE
ENSG00000119714.11	.	BCM	GRCh38.p13	chr14	91234256	91234256	+	G	G	C	Missense_Mutation	SNP	ENST00000650645.1	exon2	c.C795G	p.F265L	exonic	ENSG00000119714.11	.	nonsynonymous SNV	ENSG00000119714.11:ENST00000650645.1:exon2:c.C795G:p.F265L	14q32.11	C3L-03635	.	.	.	.	.	.	.	.	.	10.20	D	T	D	P	D	D	L	T	D	0.704	T	T	D	0.494	0.515	0.679	1.266	T	T	D	T	D	T	3.615	25.100	0.998	D	D	0.431	4.541	0.444	4.689	0.217	0.461	0.577	0.576	0.568	.	5.260	5.260	1.722	1.176	0.676	1.000	0.984	0.459	900	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV53176767;OCCURENCE=1(oesophagus)	GPR68	234	0	484	32	0.062015503875969	TRUE	TRUE
ENSG00000103742.12	.	BCM	GRCh38.p13	chr15	65396133	65396133	+	G	G	A	Missense_Mutation	SNP	ENST00000352385.3	exon7	c.C1028T	p.A343V	exonic	ENSG00000103742.12	.	nonsynonymous SNV	ENSG00000103742.12:ENST00000352385.3:exon7:c.C1028T:p.A343V	15q22.31	C3L-03635	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	N	N	T	N	0.058	T	T	D	0.126	0.375	0.340	1.514	D	T	T	T	T	T	2.905	23.200	0.992	D	N	-0.576	1.031	-0.509	1.188	1.000	0.598	0.596	0.504	0.639	.	4.140	2.190	3.765	0.142	-0.397	1.000	0.997	0.777	458	Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	IGDCC4	98	0	185	16	0.0796019900497512	TRUE	TRUE
ENSG00000167202.11	.	BCM	GRCh38.p13	chr15	78003440	78003440	+	C	C	A	Missense_Mutation	SNP	ENST00000300584.7	exon11	c.G2439T	p.L813F	exonic	ENSG00000167202.11	.	nonsynonymous SNV	ENSG00000167202.11:ENST00000300584.7:exon11:c.G2439T:p.L813F	15q25.1	C3L-03635	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	H	T	D	0.819	T	T	D	0.302	0.798	0.772	0.958	T	T	D	T	D	D	3.069	23.600	0.998	D	N	0.161	3.136	-0.055	2.181	1.000	0.722	0.699	0.723	0.714	.	5.290	1.860	-0.234	1.026	0.599	0.672	0.548	0.837	772	Rab-GTPase-TBC_domain	.	.	.	TBC1D2B	79	0	186	14	0.07	TRUE	TRUE
ENSG00000157350.13	.	BCM	GRCh38.p13	chr16	70398515	70398515	+	G	G	A	Missense_Mutation	SNP	ENST00000342907.3	exon2	c.C16T	p.R6W	exonic	ENSG00000157350.13	.	nonsynonymous SNV	ENSG00000157350.13:ENST00000342907.3:exon2:c.C16T:p.R6W	16q22.1	C3L-03635	3.485e-05	0	0	0	0	2.099e-05	0	0.0002	rs759434739	15.20	D	D	D	D	D	D	L	T	N	0.762	T	T	D	0.351	0.508	0.508	0.639	D	D	D	D	D	D	3.455	24.600	0.999	D	D	0.448	4.655	0.437	4.631	0.999	0.707	0.702	0.725	0.711	.	5.230	4.260	3.263	1.176	0.676	1.000	0.999	0.997	100	.	.	.	ID=COSV61595915;OCCURENCE=1(endometrium)	ST3GAL2	162	0	240	37	0.133574007220217	TRUE	TRUE
ENSG00000140873.16	.	BCM	GRCh38.p13	chr16	77293165	77293165	+	G	G	A	Missense_Mutation	SNP	ENST00000282849.10	exon20	c.C3100T	p.L1034F	exonic	ENSG00000140873.16	.	nonsynonymous SNV	ENSG00000140873.16:ENST00000282849.10:exon20:c.C3100T:p.L1034F	16q23.1	C3L-03635	.	.	.	.	.	.	.	.	.	3.20	D	D	B	B	N	N	L	T	N	0.238	T	T	D	0.128	0.250	0.373	.	T	T	T	T	T	T	1.131	13.060	0.987	N	N	-0.877	0.550	-1.074	0.403	1.000	0.563	0.590	0.602	0.636	.	6.160	-7.560	-0.160	-0.213	0.671	0.000	0.353	0.599	848	.	.	.	.	ADAMTS18	174	0	332	27	0.0752089136490251	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675086	7675086	+	A	A	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.T526A	p.C176S	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.T526A:p.C176S	17p13.1	C3L-03635	.	.	.	.	.	.	.	.	rs967461896	18.20	D	D	P	D	D	D	M	D	D	0.992	D	D	D	0.946	0.927	0.988	1.163	T	D	D	D	D	D	4.095	27.700	0.995	D	D	0.823	9.245	0.794	9.949	1.000	0.722	0.698	0.698	0.735	.	5.590	5.590	9.325	1.312	0.756	1.000	0.999	0.932	434	p53,_DNA-binding_domain	.	.	ID=COSV52681947;OCCURENCE=3(breast),1(liver),3(oesophagus),6(large_intestine),1(biliary_tract),2(ovary),1(NS),7(haematopoietic_and_lymphoid_tissue),2(pancreas),1(prostate),4(lung),1(thyroid),1(upper_aerodigestive_tract),1(endometrium)	TP53	393	0	498	113	0.18494271685761	TRUE	TRUE
ENSG00000091536.19	.	BCM	GRCh38.p13	chr17	18120793	18120793	+	G	G	A	Missense_Mutation	SNP	ENST00000647165.2	exon2	c.G1993A	p.V665M	exonic	ENSG00000091536.19	.	nonsynonymous SNV	ENSG00000091536.19:ENST00000647165.2:exon2:c.G1993A:p.V665M	17p11.2	C3L-03635	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	.	N	N	D	N	0.150	T	T	D	0.139	0.133	0.456	.	D	T	T	T	T	T	0.558	7.099	0.893	N	N	-1.220	0.213	-1.244	0.249	0.000	0.403	0.547	0.578	0.563	.	3.830	-1.500	0.092	0.040	0.480	0.000	0.001	0.008	247	.	.	.	.	MYO15A	110	0	160	19	0.106145251396648	TRUE	TRUE
ENSG00000130816.16	.	BCM	GRCh38.p13	chr19	10142044	10142044	+	C	C	T	Missense_Mutation	SNP	ENST00000340748.8	exon29	c.G3245A	p.R1082H	exonic	ENSG00000130816.16	.	nonsynonymous SNV	ENSG00000130816.16:ENST00000340748.8:exon29:c.G3245A:p.R1082H	19p13.2	C3L-03635	.	.	.	.	.	.	.	.	.	14.20	D	T	P	B	D	D	M	D	D	0.576	D	D	D	0.577	0.699	0.881	2.124	T	D	T	T	D	D	3.144	23.700	0.999	D	D	0.465	4.778	0.448	4.718	1.000	0.707	0.702	0.702	0.714	.	5.360	4.310	5.990	1.026	0.599	1.000	0.878	0.284	923	Bromo_adjacent_homology_(BAH)_domain	.	.	.	DNMT1	105	0	198	15	0.0704225352112676	TRUE	NA
ENSG00000130167.13	.	BCM	GRCh38.p13	chr19	11298203	11298203	+	C	C	T	Missense_Mutation	SNP	ENST00000316737.5	exon2	c.C131T	p.T44M	exonic	ENSG00000130167.13	.	nonsynonymous SNV	ENSG00000130167.13:ENST00000316737.5:exon2:c.C131T:p.T44M	19p13.2	C3L-03635	8.24e-06	9.61e-05	0	0	0	0	0	0	rs768255025	5.20	T	D	D	D	N	N	L	T	N	0.224	T	D	D	0.285	.	0.596	0.361	T	T	T	T	T	T	1.061	12.370	0.989	N	N	-0.327	1.549	-0.570	1.092	0.000	0.487	0.574	0.578	0.542	.	3.570	1.430	-0.237	0.007	0.507	0.003	0.002	0.002	814	.	.	.	ID=COSV57441936;OCCURENCE=1(central_nervous_system)	TSPAN16	316	0	523	45	0.0792253521126761	TRUE	TRUE
ENSG00000105392.16	.	BCM	GRCh38.p13	chr19	47836261	47836261	+	G	G	A	Missense_Mutation	SNP	ENST00000221996.12	exon3	c.G119A	p.R40Q	exonic	ENSG00000105392.16	.	nonsynonymous SNV	ENSG00000105392.16:ENST00000221996.12:exon3:c.G119A:p.R40Q	19q13.33	C3L-03635	8.258e-06	0	0	0	0	1.503e-05	0	0	rs771450991	20.20	D	D	D	D	D	D	H	D	D	0.875	D	D	D	0.866	0.896	0.965	0.780	D	D	D	D	D	D	4.303	29.600	0.998	D	D	0.675	6.785	0.544	5.585	1.000	0.554	0.574	0.602	0.613	.	3.670	3.670	9.235	0.973	0.581	1.000	0.998	0.954	912	Homeobox_domain	.	.	.	CRX	329	0	700	71	0.0920881971465629	TRUE	NA
ENSG00000105464.3	.	BCM	GRCh38.p13	chr19	48443764	48443764	+	C	C	A	Missense_Mutation	SNP	ENST00000263269.3	exon13	c.C3838A	p.R1280S	exonic	ENSG00000105464.3	.	nonsynonymous SNV	ENSG00000105464.3:ENST00000263269.3:exon13:c.C3838A:p.R1280S	19q13.33	C3L-03635	.	.	.	.	.	.	.	.	.	3.20	D	T	B	B	U	N	N	T	N	0.099	T	T	D	0.042	0.197	0.333	.	D	T	T	T	T	T	2.668	22.800	0.985	N	N	-0.746	0.737	-0.706	0.891	0.999	0.646	0.541	0.645	0.639	.	2.370	2.370	-1.052	0.840	0.443	0.000	0.754	0.977	958	.	.	.	.	GRIN2D	161	0	337	42	0.110817941952507	TRUE	TRUE
ENSG00000198538.11	.	BCM	GRCh38.p13	chr19	52799762	52799762	+	C	C	T	Missense_Mutation	SNP	ENST00000457749.7	exon4	c.G2083A	p.E695K	exonic	ENSG00000198538.11	.	nonsynonymous SNV	ENSG00000198538.11:ENST00000457749.7:exon4:c.G2083A:p.E695K	19q13.41	C3L-03635	.	.	.	.	.	.	.	.	.	0.19	T	T	P	B	.	N	N	T	N	0.230	T	T	T	0.043	0.517	0.169	0.046	T	T	T	T	T	T	1.491	15.680	0.967	N	N	-0.943	0.468	-1.106	0.369	0.000	0.615	0.634	0.609	0.636	.	1.780	-1.220	0.021	0.586	0.432	0.000	0.020	0.167	976	Zinc_finger_C2H2-type	.	.	.	ZNF28	357	0	559	30	0.0509337860780985	NA	TRUE
ENSG00000198300.14	.	BCM	GRCh38.p13	chr19	56817799	56817799	+	G	G	A	Missense_Mutation	SNP	ENST00000326441.15	exon9	c.C809T	p.T270M	exonic	ENSG00000198300.14	.	nonsynonymous SNV	ENSG00000198300.14:ENST00000326441.15:exon9:c.C809T:p.T270M	19q13.43	C3L-03635	0.0004	0.0007	0	0.0001	0	0.0006	0	0.0001	rs148655323	7.19	D	D	D	D	D	.	L	T	N	0.472	T	T	T	0.130	.	0.612	0.291	T	T	T	T	T	D	3.730	25.500	0.999	D	N	0.312	3.839	0.278	3.591	0.687	0.487	0.574	0.574	0.564	.	4.280	3.220	1.423	1.176	0.676	0.944	1.000	0.998	976	.	.	.	ID=COSV55624734;OCCURENCE=3(large_intestine),1(stomach),1(pancreas),1(upper_aerodigestive_tract)	PEG3	281	0	478	139	0.225283630470016	TRUE	TRUE
ENSG00000128250.5	.	BCM	GRCh38.p13	chr22	29442001	29442001	+	C	C	T	Missense_Mutation	SNP	ENST00000354373.2	exon2	c.C833T	p.P278L	exonic	ENSG00000128250.5	.	nonsynonymous SNV	ENSG00000128250.5:ENST00000354373.2:exon2:c.C833T:p.P278L	22q12.2	C3L-03635	.	.	.	.	.	.	.	.	.	2.19	T	T	P	P	.	N	M	T	D	0.226	T	T	T	0.116	0.601	0.708	0.537	T	T	T	T	T	T	0.636	7.860	0.942	N	N	-0.630	0.934	-0.873	0.658	0.000	0.554	0.588	0.668	0.530	.	1.420	0.295	0.886	0.275	0.405	0.021	0.042	0.145	527	0.000	.	.	.	RFPL1	83	0	172	32	0.156862745098039	TRUE	TRUE
ENSG00000123572.17	.	BCM	GRCh38.p13	chrX	105908732	105908732	+	C	C	T	Missense_Mutation	SNP	ENST00000243300.14	exon13	c.C1091T	p.P364L	exonic	ENSG00000123572.17	.	nonsynonymous SNV	ENSG00000123572.17:ENST00000243300.14:exon13:c.C1091T:p.P364L	Xq22.3	C3L-03635	.	.	.	.	.	.	.	.	.	8.19	D	D	P	B	N	D	N	T	D	0.220	T	T	D	0.075	0.295	0.217	.	T	D	T	T	D	T	2.315	21.700	0.998	D	.	.	.	.	.	0.002	.	.	.	.	.	4.910	4.040	1.187	1.026	0.599	0.973	0.988	0.996	35	.	.	.	.	NRK	23	0	40	14	0.259259259259259	TRUE	TRUE
ENSG00000155495.9	.	BCM	GRCh38.p13	chrX	141908144	141908144	+	G	G	A	Missense_Mutation	SNP	ENST00000285879.5	exon4	c.G2740A	p.E914K	exonic	ENSG00000155495.9	.	nonsynonymous SNV	ENSG00000155495.9:ENST00000285879.5:exon4:c.G2740A:p.E914K	Xq27.2	C3L-03635	.	.	.	.	.	.	.	.	.	3.18	D	T	P	B	.	N	L	T	D	0.178	T	T	T	0.036	0.426	0.191	.	T	T	T	T	D	T	0.944	10.920	0.983	N	.	.	.	.	.	0.000	.	.	.	.	.	0.837	0.837	0.162	-1.122	0.303	0.006	0.001	0.077	987	MAGE_homology_domain	.	.	.	MAGEC1	112	0	192	27	0.123287671232877	TRUE	NA
ENSG00000158125.10	.	BCM	GRCh38.p13	chr2	31379977	31379977	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000158125.10	ENST00000379416.4:exon13:c.1133-1G>A	.	.	2p23.1	C3L-03635	.	.	.	.	.	.	.	.	rs1028214638	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.210	33	0.993	D	.	1.053	15.675	0.884	13.067	1.000	0.061	0.060	0.063	0.057	0.980	6.100	6.100	7.327	1.026	0.599	1.000	0.274	0.075	928	.	.	.	.	XDH	524	0	836	48	0.0542986425339367	TRUE	NA
ENSG00000115155.18	.	BCM	GRCh38.p13	chr2	26464087	26464087	+	G	G	A	Silent	SNP	ENST00000272371.7	exon40	c.C4980T	p.D1660D	exonic	ENSG00000115155.18	.	synonymous SNV	ENSG00000115155.18:ENST00000272371.7:exon40:c.C4980T:p.D1660D	2p23.3	C3L-03635	0.0005	0.0048	0	0	0	3.046e-05	0	0.0008	rs149549554	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55501671;OCCURENCE=1(oesophagus),1(large_intestine)	OTOF	208	0	455	30	0.0618556701030928	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178548443	178548443	+	A	A	G	Silent	SNP	ENST00000591111.5	exon289	c.T88260C	p.R29420R	exonic	ENSG00000155657.27	.	synonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon289:c.T88260C:p.R29420R	2q31.2	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59972555;OCCURENCE=1(large_intestine)	TTN	211	0	397	26	0.0614657210401891	TRUE	TRUE
ENSG00000144619.15	.	BCM	GRCh38.p13	chr3	2988399	2988399	+	C	C	T	Silent	SNP	ENST00000418658.6	exon14	c.C1413T	p.D471D	exonic	ENSG00000144619.15	.	synonymous SNV	ENSG00000144619.15:ENST00000418658.6:exon14:c.C1413T:p.D471D	3p26.2	C3L-03635	.	.	.	.	.	.	.	.	rs1037405854	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61867980;OCCURENCE=3(oesophagus),1(lung),1(endometrium)	CNTN4	264	0	315	28	0.0816326530612245	TRUE	TRUE
ENSG00000088727.12	.	BCM	GRCh38.p13	chr3	47236058	47236058	+	G	G	T	Silent	SNP	ENST00000335044.6	exon19	c.C2193A	p.V731V	exonic	ENSG00000088727.12	.	synonymous SNV	ENSG00000088727.12:ENST00000335044.6:exon19:c.C2193A:p.V731V	3p21.31	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIF9	200	0	386	25	0.0608272506082725	TRUE	TRUE
ENSG00000113924.12	.	BCM	GRCh38.p13	chr3	120638492	120638492	+	C	C	T	Silent	SNP	ENST00000283871.10	exon12	c.G969A	p.G323G	exonic	ENSG00000113924.12	.	synonymous SNV	ENSG00000113924.12:ENST00000283871.10:exon12:c.G969A:p.G323G	3q13.33	C3L-03635	0.0001	0	8.64e-05	0	0	0.0002	0	0	rs376724242	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HGD	368	0	612	49	0.0741301059001513	TRUE	NA
ENSG00000204963.6	.	BCM	GRCh38.p13	chr5	140834680	140834680	+	C	C	T	Silent	SNP	ENST00000525929.2	exon1	c.C297T	p.S99S	exonic	ENSG00000204963.6	.	synonymous SNV	ENSG00000204963.6:ENST00000525929.2:exon1:c.C297T:p.S99S	5q31.3	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65344985;OCCURENCE=1(endometrium)	PCDHA7	588	1	782	77	0.089639115250291	NA	TRUE
ENSG00000112818.10	.	BCM	GRCh38.p13	chr6	46834579	46834579	+	G	G	T	Silent	SNP	ENST00000230588.9	exon12	c.G1611T	p.A537A	exonic	ENSG00000112818.10	.	synonymous SNV	ENSG00000112818.10:ENST00000230588.9:exon12:c.G1611T:p.A537A	6p12.3	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MEP1A	50	0	126	10	0.0735294117647059	NA	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152331134	152331134	+	A	A	G	Silent	SNP	ENST00000367255.10	exon78	c.T13551C	p.G4517G	exonic	ENSG00000131018.24	.	synonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon78:c.T13551C:p.G4517G	6q25.2	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SYNE1	356	0	534	32	0.0565371024734982	TRUE	TRUE
ENSG00000104365.15	.	BCM	GRCh38.p13	chr8	42306405	42306405	+	A	A	G	Silent	SNP	ENST00000520810.6	exon7	c.A540G	p.T180T	exonic	ENSG00000104365.15	.	synonymous SNV	ENSG00000104365.15:ENST00000520810.6:exon7:c.A540G:p.T180T	8p11.21	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IKBKB	189	0	413	34	0.0760626398210291	TRUE	TRUE
ENSG00000147804.10	.	BCM	GRCh38.p13	chr8	144415375	144415375	+	C	C	T	Silent	SNP	ENST00000301305.8	exon3	c.G519A	p.A173A	exonic	ENSG00000147804.10	.	synonymous SNV	ENSG00000147804.10:ENST00000301305.8:exon3:c.G519A:p.A173A	8q24.3	C3L-03635	1.217e-05	0	0	0	0	0	0	7.428e-05	rs782696621	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC39A4	155	0	310	26	0.0773809523809524	TRUE	NA
ENSG00000041982.16	.	BCM	GRCh38.p13	chr9	115078106	115078106	+	G	G	A	Silent	SNP	ENST00000350763.9	exon7	c.C2511T	p.Y837Y	exonic	ENSG00000041982.16	.	synonymous SNV	ENSG00000041982.16:ENST00000350763.9:exon7:c.C2511T:p.Y837Y	9q33.1	C3L-03635	9.069e-05	0.0006	8.649e-05	0	0	3e-05	0	0.0001	rs146641282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60788749;OCCURENCE=1(central_nervous_system),1(ovary)	TNC	200	0	354	43	0.10831234256927	TRUE	TRUE
ENSG00000107611.16	.	BCM	GRCh38.p13	chr10	17084460	17084460	+	C	C	T	Silent	SNP	ENST00000377833.10	exon17	c.G2112A	p.S704S	exonic	ENSG00000107611.16	.	synonymous SNV	ENSG00000107611.16:ENST00000377833.10:exon17:c.G2112A:p.S704S	10p13	C3L-03635	9.215e-06	0	0	0	0	0	0	6.592e-05	rs774463666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64716375;OCCURENCE=1(skin)	CUBN	447	0	682	47	0.0644718792866941	TRUE	TRUE
ENSG00000165383.11	.	BCM	GRCh38.p13	chr10	48913532	48913532	+	C	C	T	Silent	SNP	ENST00000374160.7	exon1	c.G624A	p.A208A	exonic	ENSG00000165383.11	.	synonymous SNV	ENSG00000165383.11:ENST00000374160.7:exon1:c.G624A:p.A208A	10q11.23	C3L-03635	8.236e-06	0	0	0	0	1.498e-05	0	0	rs750366620	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53282970;OCCURENCE=1(stomach),1(endometrium)	LRRC18	345	0	544	105	0.161787365177196	TRUE	TRUE
ENSG00000220948.5	.	BCM	GRCh38.p13	chr11	48980948	48980948	+	G	G	A	Silent	SNP	ENST00000649162.1	exon3	c.C465T	p.H155H	exonic	ENSG00000220948.5	.	synonymous SNV	ENSG00000220948.5:ENST00000649162.1:exon3:c.C465T:p.H155H	11p11.12	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIM51GP	201	0	299	18	0.056782334384858	TRUE	NA
ENSG00000111432.4	.	BCM	GRCh38.p13	chr12	130163758	130163758	+	C	C	T	Silent	SNP	ENST00000229030.4	exon1	c.C816T	p.V272V	exonic	ENSG00000111432.4	.	synonymous SNV	ENSG00000111432.4:ENST00000229030.4:exon1:c.C816T:p.V272V	12q24.33	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FZD10	220	0	439	41	0.0854166666666667	TRUE	TRUE
ENSG00000159433.12	.	BCM	GRCh38.p13	chr15	42686336	42686336	+	T	T	C	Silent	SNP	ENST00000290607.12	exon23	c.T4758C	p.Y1586Y	exonic	ENSG00000159433.12	.	synonymous SNV	ENSG00000159433.12:ENST00000290607.12:exon23:c.T4758C:p.Y1586Y	15q15.2	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STARD9	257	0	344	29	0.0777479892761394	TRUE	TRUE
ENSG00000140521.15	.	BCM	GRCh38.p13	chr15	89317488	89317488	+	G	G	A	Silent	SNP	ENST00000442287.6	exon22	c.C3531T	p.V1177V	exonic	ENSG00000140521.15	.	synonymous SNV	ENSG00000140521.15:ENST00000442287.6:exon22:c.C3531T:p.V1177V	15q26.1	C3L-03635	.	.	.	.	.	.	.	.	rs1060504039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51520403;OCCURENCE=1(stomach)	POLG	547	0	733	59	0.0744949494949495	TRUE	TRUE
ENSG00000182481.9	.	BCM	GRCh38.p13	chr17	68037471	68037471	+	G	G	A	Silent	SNP	ENST00000330459.8	exon3	c.G189A	p.P63P	exonic	ENSG00000182481.9	.	synonymous SNV	ENSG00000182481.9:ENST00000330459.8:exon3:c.G189A:p.P63P	17q24.2	C3L-03635	8.248e-06	0	0	0	0	1.501e-05	0	0	rs782745827	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57857337;OCCURENCE=2(central_nervous_system)	KPNA2	159	0	201	27	0.118421052631579	NA	TRUE
ENSG00000196268.11	.	BCM	GRCh38.p13	chr19	21423985	21423985	+	T	T	C	Silent	SNP	ENST00000355504.4	exon2	c.T942C	p.F314F	exonic	ENSG00000196268.11	.	synonymous SNV	ENSG00000196268.11:ENST00000355504.4:exon2:c.T942C:p.F314F	19p12	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF493	367	0	444	38	0.0788381742738589	NA	TRUE
ENSG00000184032.3	.	BCM	GRCh38.p13	chr21	30635320	30635320	+	C	C	T	Silent	SNP	ENST00000330798.3	exon1	c.C57T	p.G19G	exonic	ENSG00000184032.3	.	synonymous SNV	ENSG00000184032.3:ENST00000330798.3:exon1:c.C57T:p.G19G	21q22.11	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58182517;OCCURENCE=3(large_intestine),1(bone),1(endometrium)	KRTAP20-2	455	1	572	105	0.155096011816839	TRUE	TRUE
ENSG00000160886.13	.	BCM	GRCh38.p13	chr8	142700490	142700490	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000160886.13	ENST00000292430.10:c.-38C>T	.	.	8q24.3	C3L-03635	4.56e-05	0	0	0	0	0.0001	0	0	rs782374804	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LY6K	126	0	404	25	0.0582750582750583	TRUE	NA
ENSG00000207930.1	.	BCM	GRCh38.p13	chr10	24275721	24275721	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000207930.1	.	.	.	10p12.2	C3L-03635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR603	194	1	283	43	0.131901840490798	TRUE	NA
ENSG00000135127.11	.	BCM	GRCh38.p13	chr12	120094305	120094305	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000135127.11	ENST00000397558.6:c.*1144G>A	.	.	12q24.23	C3L-03635	7.113e-05	0	0	0	0	0.0003	0	0	rs545012687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BICDL1	129	0	285	23	0.0746753246753247	TRUE	NA
ENSG00000092051.17	.	BCM	GRCh38.p13	chr14	23572962	23572962	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000092051.17	.	.	.	14q11.2	C3L-03635	.	.	.	.	.	.	.	.	rs552590147	1.15	D	.	B	B	.	N	.	T	N	0.034	T	T	T	0.021	0.269	0.129	.	.	.	T	T	T	T	-0.165	0.606	0.961	N	N	-1.191	0.234	-1.306	0.205	1.000	0.660	0.492	0.696	0.530	.	3.200	-2.250	-1.412	-0.403	-0.273	0.000	0.022	0.206	627	.	.	.	.	JPH4	87	0	162	42	0.205882352941176	TRUE	NA
ENSG00000095002.15	.	BCM	GRCh38.p13	chr2	47403271	47403271	+	C	C	T	Missense_Mutation	SNP	ENST00000233146.7	exon1	c.C80T	p.P27L	exonic	ENSG00000095002.15	.	nonsynonymous SNV	ENSG00000095002.15:ENST00000233146.7:exon1:c.C80T:p.P27L	2p21	C3N-00518	5.282e-05	0.0002	0	0	0	6.336e-05	0	0	rs750746034	18.20	D	D	D	P	D	D	M	D	D	0.669	D	D	D	0.683	.	0.865	0.028	T	D	D	D	D	D	4.284	29.400	0.999	D	D	0.742	7.743	0.711	7.973	1.000	0.442	0.522	0.522	0.562	.	5.570	5.570	5.469	1.022	0.593	1.000	1.000	0.991	786	DNA_mismatch_repair_protein_MutS-like,_N-terminal	.	.	.	MSH2	688	0	894	62	0.0648535564853557	TRUE	NA
ENSG00000115665.9	.	BCM	GRCh38.p13	chr2	107992156	107992156	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000264047.3	exon3	c.230dupT	p.P78Tfs*17	exonic	ENSG00000115665.9	.	frameshift insertion	ENSG00000115665.9:ENST00000264047.3:exon3:c.230dupT:p.P78Tfs*17	2q12.3	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC5A7	NA	NA	NA	NA	NA	NA	NA
ENSG00000131378.14	.	BCM	GRCh38.p13	chr3	16316899	16316899	+	T	T	G	Missense_Mutation	SNP	ENST00000334133.9	exon10	c.A1666C	p.N556H	exonic	ENSG00000131378.14	.	nonsynonymous SNV	ENSG00000131378.14:ENST00000334133.9:exon10:c.A1666C:p.N556H	3p24.3	C3N-00518	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.074	T	T	T	0.010	0.091	0.154	0.112	T	T	T	T	T	T	-0.175	0.577	0.620	N	N	-1.449	0.098	-1.471	0.119	1.000	0.707	0.702	0.696	0.714	.	4.760	-2.860	-2.605	-1.797	-0.379	0.000	0.000	0.010	685	.	.	.	.	RFTN1	592	0	649	54	0.0768136557610242	TRUE	TRUE
ENSG00000163833.8	.	BCM	GRCh38.p13	chr3	121621580	121621580	+	G	G	A	Missense_Mutation	SNP	ENST00000338040.6	exon3	c.G151A	p.E51K	exonic	ENSG00000163833.8	.	nonsynonymous SNV	ENSG00000163833.8:ENST00000338040.6:exon3:c.G151A:p.E51K	3q13.33	C3N-00518	.	.	.	.	.	.	.	.	.	7.20	D	T	P	P	N	D	M	T	N	0.495	T	T	T	0.083	0.335	0.610	0.389	T	T	T	T	D	D	3.855	26.100	0.999	D	D	0.614	6.067	0.636	6.703	0.975	0.497	0.590	0.547	0.530	.	5.470	5.470	5.430	1.176	0.676	1.000	1.000	0.992	355	Zinc_finger,_TRAF-type	.	.	ID=COSV104647279;OCCURENCE=1(skin)	FBXO40	247	2	375	35	0.0853658536585366	TRUE	TRUE
ENSG00000173175.14	.	BCM	GRCh38.p13	chr3	123447759	123447759	+	G	G	A	Missense_Mutation	SNP	ENST00000462833.5	exon1	c.C787T	p.R263W	exonic	ENSG00000173175.14	.	nonsynonymous SNV	ENSG00000173175.14:ENST00000462833.5:exon1:c.C787T:p.R263W	3q21.1	C3N-00518	.	.	.	.	.	.	.	.	.	5.20	T	D	P	P	N	N	N	T	N	0.193	T	T	D	0.280	0.480	0.592	0.921	T	T	T	T	D	T	2.710	22.800	0.994	D	D	-0.276	1.675	-0.217	1.744	1.000	0.598	0.590	0.607	0.639	.	4.910	1.870	0.610	-0.207	-0.199	0.224	0.211	0.097	835	Adenylate_cyclase,_N-terminal	.	.	ID=COSV71901312;OCCURENCE=1(central_nervous_system)	ADCY5	130	0	158	10	0.0595238095238095	TRUE	TRUE
ENSG00000135226.18	.	BCM	GRCh38.p13	chr4	69280732	69280732	+	C	C	G	Missense_Mutation	SNP	ENST00000335568.10	exon1	c.C232G	p.P78A	exonic	ENSG00000135226.18	.	nonsynonymous SNV	ENSG00000135226.18:ENST00000335568.10:exon1:c.C232G:p.P78A	4q13.2	C3N-00518	.	.	.	.	.	.	.	.	.	6.20	D	D	D	P	U	N	M	T	D	0.184	T	T	T	0.132	0.548	0.260	0.198	T	T	T	T	D	T	1.092	12.690	0.958	N	N	-0.611	0.969	-0.910	0.607	0.000	0.487	0.574	0.574	0.564	.	2.180	-1.610	-0.247	-0.824	0.435	0.000	0.001	0.010	884	.	.	.	.	UGT2B28	73	0	307	33	0.0970588235294118	NA	TRUE
ENSG00000177839.7	.	BCM	GRCh38.p13	chr5	141189474	141189474	+	C	C	T	Missense_Mutation	SNP	ENST00000316105.7	exon1	c.C2156T	p.A719V	exonic	ENSG00000177839.7	.	nonsynonymous SNV	ENSG00000177839.7:ENST00000316105.7:exon1:c.C2156T:p.A719V	5q31.3	C3N-00518	.	.	.	.	.	.	.	.	.	0.5	.	T	.	.	.	.	.	.	.	0.245	.	.	.	.	.	0.600	.	T	.	T	T	.	.	2.219	21.000	0.957	N	.	.	.	.	.	0.004	0.078	0.097	0.084	0.063	0.053	3.630	-3.200	-0.120	0.910	0.323	0.015	0.050	0.034	672	.	.	.	ID=COSV53376611;OCCURENCE=1(oesophagus)	PCDHB9	535	0	605	43	0.066358024691358	NA	TRUE
ENSG00000204695.4	.	BCM	GRCh38.p13	chr6	29307134	29307134	+	G	G	T	Missense_Mutation	SNP	ENST00000641895.1	exon2	c.G445T	p.A149S	exonic	ENSG00000204695.4	.	nonsynonymous SNV	ENSG00000204695.4:ENST00000641895.1:exon2:c.G445T:p.A149S	6p22.1	C3N-00518	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	T	N	0.054	T	T	T	0.074	0.357	0.146	0.190	T	T	T	T	T	.	0.350	4.864	0.273	N	N	-1.281	0.175	-1.168	0.311	0.000	0.487	0.590	0.547	0.564	.	4.860	-0.284	-1.811	0.770	0.656	0.000	0.992	0.996	774	GPCR,_rhodopsin-like,_7TM	.	.	.	OR14J1	309	0	410	40	0.0888888888888889	TRUE	TRUE
ENSG00000112541.16	.	BCM	GRCh38.p13	chr6	165395261	165395261	+	G	G	T	Missense_Mutation	SNP	ENST00000539869.3	exon15	c.C2223A	p.F741L	exonic	ENSG00000112541.16	.	nonsynonymous SNV	ENSG00000112541.16:ENST00000539869.3:exon15:c.C2223A:p.F741L	6q27	C3N-00518	8.428e-06	0	0	0	0	0	0	6.197e-05	rs773851683	8.16	.	.	B	B	N	D	M	.	.	.	T	T	D	0.383	0.614	0.641	1.125	T	D	T	T	D	D	2.778	23.000	0.993	D	D	0.007	2.537	0.132	2.871	0.034	0.638	0.574	0.574	0.668	.	5.570	3.790	5.511	1.176	0.676	1.000	1.000	1.000	993	3'5'-cyclic_nucleotide_phosphodiesterase,_catalytic_domain	.	.	.	PDE10A	74	0	271	28	0.0936454849498328	TRUE	NA
ENSG00000155897.10	.	BCM	GRCh38.p13	chr8	130909727	130909727	+	C	C	T	Missense_Mutation	SNP	ENST00000286355.10	exon6	c.G1621A	p.E541K	exonic	ENSG00000155897.10	.	nonsynonymous SNV	ENSG00000155897.10:ENST00000286355.10:exon6:c.G1621A:p.E541K	8q24.22	C3N-00518	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.969	D	D	D	0.904	0.875	0.995	1.345	D	D	D	D	D	D	4.287	29.500	0.999	D	D	1.145	19.741	1.050	22.321	1.000	0.638	0.574	0.653	0.542	.	5.930	5.930	7.905	1.026	0.599	1.000	0.989	0.998	708	Adenylyl_cyclase_class-3/4/guanylyl_cyclase;Adenylyl_cyclase_class-4/guanylyl_cyclase,_conserved_site	.	.	ID=COSV53903634;OCCURENCE=1(liver),1(NS),3(skin)	ADCY8	220	0	329	33	0.0911602209944751	TRUE	TRUE
ENSG00000042832.12	.	BCM	GRCh38.p13	chr8	132923467	132923467	+	G	G	A	Nonsense_Mutation	SNP	ENST00000220616.9	exon22	c.G4658A	p.W1553X	exonic	ENSG00000042832.12	.	stopgain	ENSG00000042832.12:ENST00000220616.9:exon22:c.G4658A:p.W1553X	8q24.22	C3N-00518	.	.	.	.	.	.	.	.	.	5.7	.	.	.	.	N	A	.	.	.	0.949	.	.	.	.	.	.	.	.	.	D	D	D	.	7.704	39	0.989	D	N	0.355	4.077	0.093	2.705	0.986	0.487	0.590	0.574	0.564	.	4.770	3.890	4.469	1.176	0.610	1.000	0.023	0.097	686	Thyroglobulin_type-1	.	.	.	TG	280	0	312	44	0.123595505617978	TRUE	TRUE
ENSG00000185122.11	.	BCM	GRCh38.p13	chr8	144309584	144309584	+	T	T	G	Missense_Mutation	SNP	ENST00000528838.6	exon3	c.T356G	p.V119G	exonic	ENSG00000185122.11	.	nonsynonymous SNV	ENSG00000185122.11:ENST00000528838.6:exon3:c.T356G:p.V119G	8q24.3	C3N-00518	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	L	D	D	0.460	D	D	D	0.754	0.500	0.858	0.853	T	D	D	D	D	.	3.430	24.500	0.997	D	D	0.693	7.021	0.664	7.133	1.000	0.707	0.702	0.723	0.714	.	5.470	5.470	4.177	0.168	0.663	1.000	0.990	0.991	946	.	.	.	.	HSF1	224	0	354	37	0.0946291560102302	TRUE	TRUE
ENSG00000196422.11	.	BCM	GRCh38.p13	chr9	135487640	135487640	+	T	T	C	Missense_Mutation	SNP	ENST00000356818.7	exon4	c.T3130C	p.S1044P	exonic	ENSG00000196422.11	.	nonsynonymous SNV	ENSG00000196422.11:ENST00000356818.7:exon4:c.T3130C:p.S1044P	9q34.3	C3N-00518	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.047	T	T	T	0.007	0.242	0.043	0.330	T	T	T	T	T	T	0.503	6.533	0.330	N	N	-1.445	0.099	-1.518	0.101	1.000	0.696	0.588	0.723	0.636	.	4.700	-7.280	-1.157	-0.215	-0.176	0.000	0.000	0.004	508	.	.	.	.	PPP1R26	29	0	79	6	0.0705882352941176	NA	TRUE
ENSG00000149782.11	.	BCM	GRCh38.p13	chr11	64267192	64267192	+	A	A	G	Missense_Mutation	SNP	ENST00000540288.5	exon30	c.A3422G	p.E1141G	exonic	ENSG00000149782.11	.	nonsynonymous SNV	ENSG00000149782.11:ENST00000540288.5:exon30:c.A3422G:p.E1141G	11q13.1	C3N-00518	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	L	T	D	0.247	T	T	D	0.321	0.666	0.572	0.844	T	T	T	T	D	D	4.604	32	0.997	D	D	0.376	4.195	0.326	3.870	1.000	0.722	0.694	0.725	0.735	.	4.420	3.270	4.383	1.228	0.658	1.000	1.000	0.991	654	Phospholipase_C-beta,_C-terminal_domain	.	.	.	PLCB3	271	1	437	32	0.0682302771855011	TRUE	TRUE
ENSG00000137713.16	.	BCM	GRCh38.p13	chr11	111764855	111764855	+	C	C	T	Missense_Mutation	SNP	ENST00000527614.6	exon3	c.G256A	p.G86R	exonic	ENSG00000137713.16	.	nonsynonymous SNV	ENSG00000137713.16:ENST00000527614.6:exon3:c.G256A:p.G86R	11q23.1	C3N-00518	8.258e-06	0	0	0	0	0	0	6.081e-05	rs782540147	15.20	D	D	D	P	D	D	H	T	D	0.952	T	T	D	0.488	0.720	0.727	0.890	D	T	D	D	D	D	3.976	26.800	0.999	D	D	0.861	10.086	0.798	10.054	1.000	0.722	0.672	0.663	0.735	.	5.280	5.280	7.317	1.013	0.599	1.000	1.000	0.999	106	.	.	.	.	PPP2R1B	248	0	456	38	0.0769230769230769	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227341	25227341	+	T	T	G	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A183C	p.Q61H	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A183C:p.Q61H	12p12.1	C3N-00518	.	.	.	.	.	.	.	.	rs17851045	17.20	D	D	B	B	D	D	M	D	D	0.760	D	D	D	0.644	0.659	0.905	1.857	D	D	D	D	D	T	2.993	23.400	0.997	D	D	0.298	3.768	0.383	4.239	0.998	0.722	0.710	0.710	0.735	.	5.770	5.770	2.812	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55498802;OCCURENCE=2(breast),6(liver),1(genital_tract),1(cervix),117(large_intestine),2(central_nervous_system),17(biliary_tract),3(ovary),8(stomach),50(haematopoietic_and_lymphoid_tissue),2(urinary_tract),1(kidney),71(pancreas),2(skin),2(prostate),28(lung),1(thyroid),2(small_intestine),5(endometrium)	KRAS	106	0	335	50	0.12987012987013	TRUE	TRUE
ENSG00000166866.13	.	BCM	GRCh38.p13	chr12	57038471	57038471	+	G	G	C	Missense_Mutation	SNP	ENST00000300119.8	exon17	c.C1701G	p.F567L	exonic	ENSG00000166866.13	.	nonsynonymous SNV	ENSG00000166866.13:ENST00000300119.8:exon17:c.C1701G:p.F567L	12q13.3	C3N-00518	.	.	.	.	.	.	.	.	.	15.20	D	T	D	D	D	D	M	T	D	0.706	D	D	D	0.643	0.767	0.794	0.334	T	D	T	T	D	D	3.197	23.900	0.999	D	D	0.641	6.374	0.524	5.383	1.000	0.516	0.547	0.602	0.586	.	4.940	3.080	4.883	0.236	0.662	1.000	1.000	0.999	174	Class_I_myosin,_motor_domain;Myosin_head,_motor_domain	.	.	ID=COSV100271499;OCCURENCE=1(testis)	MYO1A	661	0	941	55	0.0552208835341365	TRUE	NA
ENSG00000188603.20	.	BCM	GRCh38.p13	chr16	28477817	28477817	+	G	G	C	Missense_Mutation	SNP	ENST00000635887.1	exon15	c.C1117G	p.L373V	exonic	ENSG00000188603.20;ENSG00000261832.6	.	nonsynonymous SNV	ENSG00000261832.6:ENST00000635887.1:exon15:c.C1117G:p.L373V,ENSG00000188603.20:ENST00000569430.6:exon16:c.C1117G:p.L373V	16p12.1	C3N-00518	.	.	.	.	.	.	.	.	rs752700529	6.20	T	T	P	P	N	D	M	T	N	0.378	T	T	D	0.082	0.445	0.762	0.195	T	D	D	T	T	T	1.253	14.050	0.981	D	N	-0.719	0.781	-0.708	0.889	0.002	0.707	0.725	0.805	0.714	.	5.290	-0.350	0.193	-0.124	-0.108	0.991	0.919	0.973	749	.	.	.	.	CLN3	565	0	752	71	0.086269744835966	TRUE	NA
ENSG00000178921.14	.	BCM	GRCh38.p13	chr17	8256633	8256633	+	C	C	T	Missense_Mutation	SNP	ENST00000314666.11	exon8	c.C931T	p.H311Y	exonic	ENSG00000178921.14	.	nonsynonymous SNV	ENSG00000178921.14:ENST00000314666.11:exon8:c.C931T:p.H311Y	17p13.1	C3N-00518	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.964	D	D	T	0.545	0.899	0.913	0.914	T	D	D	D	D	D	3.714	25.500	0.998	D	D	1.028	14.812	0.903	13.881	1.000	0.707	0.702	0.702	0.714	.	5.220	5.220	5.436	1.026	0.599	1.000	0.986	0.989	484	.	.	.	.	PFAS	188	0	225	28	0.110671936758893	TRUE	TRUE
ENSG00000187775.17	.	BCM	GRCh38.p13	chr17	78449575	78449575	+	C	C	T	Missense_Mutation	SNP	ENST00000389840.7	exon69	c.G11050A	p.V3684M	exonic	ENSG00000187775.17	.	nonsynonymous SNV	ENSG00000187775.17:ENST00000389840.7:exon69:c.G11050A:p.V3684M	17q25.3	C3N-00518	3.009e-05	0	0	0	0	2.758e-05	0	9.615e-05	rs772970929	6.13	.	.	.	.	N	D	.	T	.	0.246	T	T	D	0.201	.	0.220	.	T	.	T	T	D	D	1.390	15.010	0.984	D	D	-0.134	2.070	-0.157	1.893	0.077	0.706	0.710	0.602	0.613	.	4.700	2.710	3.312	0.130	-0.187	0.995	0.994	0.322	878	.	.	.	.	DNAH17	137	2	168	18	0.0967741935483871	TRUE	NA
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51047258	51047258	+	G	G	A	Missense_Mutation	SNP	ENST00000342988.8	exon2	c.G212A	p.C71Y	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon2:c.G212A:p.C71Y	18q21.2	C3N-00518	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.935	D	D	D	0.901	0.909	0.980	4.141	D	D	D	D	D	D	4.228	28.900	0.998	D	D	1.081	16.708	1.015	19.772	1.000	0.706	0.725	0.710	0.613	.	5.640	5.640	10.003	1.161	0.676	1.000	1.000	1.000	672	MAD_homology_1,_Dwarfin-type;MAD_homology,_MH1	.	.	.	SMAD4	61	0	371	43	0.103864734299517	TRUE	TRUE
ENSG00000105617.4	.	BCM	GRCh38.p13	chr19	54156787	54156787	+	C	C	T	Missense_Mutation	SNP	ENST00000222224.4	exon3	c.G551A	p.G184E	exonic	ENSG00000105617.4	.	nonsynonymous SNV	ENSG00000105617.4:ENST00000222224.4:exon3:c.G551A:p.G184E	19q13.42	C3N-00518	8.295e-06	9.614e-05	0	0	0	0	0	0	rs551528484	0.15	T	T	.	.	N	N	.	T	N	0.111	T	T	T	0.075	0.235	0.232	0.024	T	.	T	T	T	.	-0.797	0.026	0.843	N	N	-1.311	0.159	-1.417	0.143	1.000	0.461	0.577	0.576	0.636	.	4.410	-7.060	-3.258	0.114	0.580	0.000	0.007	0.861	994	.	.	.	.	LENG1	163	0	181	12	0.0621761658031088	TRUE	NA
ENSG00000157557.13	.	BCM	GRCh38.p13	chr21	38818467	38818467	+	A	A	C	Missense_Mutation	SNP	ENST00000360938.8	exon7	c.A632C	p.N211T	exonic	ENSG00000157557.13	.	nonsynonymous SNV	ENSG00000157557.13:ENST00000360938.8:exon7:c.A632C:p.N211T	21q22.2	C3N-00518	.	.	.	.	.	.	.	.	.	1.20	D	T	B	B	N	N	L	T	N	0.281	T	T	T	0.066	0.259	0.569	0.335	T	T	T	T	T	T	-0.408	0.185	0.925	N	N	-1.225	0.210	-1.345	0.181	1.000	0.672	0.654	0.698	0.711	.	6.160	-8.290	-0.199	1.312	0.756	0.000	0.139	0.149	566	.	.	.	.	ETS2	561	0	819	79	0.0879732739420935	TRUE	TRUE
ENSG00000183963.18	.	BCM	GRCh38.p13	chr22	31098840	31098840	+	G	G	A	Missense_Mutation	SNP	ENST00000347557.6	exon17	c.G2333A	p.G778D	exonic	ENSG00000183963.18	.	nonsynonymous SNV	ENSG00000183963.18:ENST00000347557.6:exon17:c.G2333A:p.G778D	22q12.2	C3N-00518	.	.	.	.	.	.	.	.	.	16.20	D	D	D	P	N	D	L	D	D	0.356	D	D	D	0.234	0.263	0.599	1.181	T	D	D	D	D	D	4.505	32	0.998	D	D	0.304	3.799	0.359	4.080	1.000	0.789	0.709	0.768	0.711	.	4.760	4.760	9.115	1.176	0.676	1.000	0.083	0.169	632	.	.	.	.	SMTN	166	0	303	20	0.0619195046439628	TRUE	TRUE
ENSG00000085185.15	.	BCM	GRCh38.p13	chrX	130014609	130014609	+	T	T	-	Frame_Shift_Del	NA	ENST00000540052.5	exon3	c.1837delT	p.S613Lfs*35	exonic	ENSG00000085185.15	.	frameshift deletion	ENSG00000085185.15:ENST00000540052.5:exon3:c.1837delT:p.S613Lfs*35	Xq26.1	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BCORL1	107	0	156	36	0.1875	TRUE	TRUE
ENSG00000138035.15	.	BCM	GRCh38.p13	chr2	55656130	55656130	+	C	C	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000138035.15	ENST00000447944.7:exon17:c.1441+1G>C	.	.	2p16.1	C3N-00518	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.858	35	0.995	D	.	1.067	16.207	0.887	13.201	1.000	0.164	0.157	0.084	0.110	0.983	4.820	4.820	7.565	1.026	0.599	1.000	0.959	0.911	423	.	.	.	.	PNPT1	30	0	170	11	0.0607734806629834	TRUE	TRUE
ENSG00000153093.18	.	BCM	GRCh38.p13	chr2	111031680	111031680	+	C	C	T	Silent	SNP	ENST00000389811.8	exon16	c.C1425T	p.H475H	exonic	ENSG00000153093.18	.	synonymous SNV	ENSG00000153093.18:ENST00000389811.8:exon16:c.C1425T:p.H475H	2q13	C3N-00518	8.239e-06	0	0	0	0	0	0	6.056e-05	rs757294119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACOXL	290	0	413	30	0.0677200902934537	TRUE	NA
ENSG00000107789.16	.	BCM	GRCh38.p13	chr10	87505506	87505506	+	G	G	T	Silent	SNP	ENST00000371996.9	exon1	c.G591T	p.G197G	exonic	ENSG00000107789.16	.	synonymous SNV	ENSG00000107789.16:ENST00000371996.9:exon1:c.G591T:p.G197G	10q23.2	C3N-00518	.	.	.	.	.	.	.	.	rs910432787	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MINPP1	191	0	290	42	0.126506024096386	TRUE	NA
ENSG00000170468.8	.	BCM	GRCh38.p13	chr14	73491938	73491938	+	T	T	A	Silent	SNP	ENST00000304061.8	exon1	c.T921A	p.T307T	exonic	ENSG00000170468.8	.	synonymous SNV	ENSG00000170468.8:ENST00000304061.8:exon1:c.T921A:p.T307T	14q24.3	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RIOX1	221	0	365	39	0.0965346534653465	TRUE	TRUE
ENSG00000090905.19	.	BCM	GRCh38.p13	chr16	24806675	24806675	+	A	A	T	Silent	SNP	ENST00000395799.8	exon17	c.A4431T	p.P1477P	exonic	ENSG00000090905.19	.	synonymous SNV	ENSG00000090905.19:ENST00000395799.8:exon17:c.A4431T:p.P1477P	16p12.1	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TNRC6A	692	0	955	107	0.10075329566855	TRUE	TRUE
ENSG00000160299.17	.	BCM	GRCh38.p13	chr21	46334495	46334495	+	C	C	T	Silent	SNP	ENST00000359568.10	exon3	c.C366T	p.V122V	exonic	ENSG00000160299.17	.	synonymous SNV	ENSG00000160299.17:ENST00000359568.10:exon3:c.C366T:p.V122V	21q22.3	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCNT	597	0	820	76	0.0848214285714286	TRUE	TRUE
ENSG00000182872.16	.	BCM	GRCh38.p13	chrX	47185790	47185790	+	G	G	A	Silent	SNP	ENST00000377604.8	exon21	c.G2430A	p.E810E	exonic	ENSG00000182872.16	.	synonymous SNV	ENSG00000182872.16:ENST00000377604.8:exon21:c.G2430A:p.E810E	Xp11.3	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBM10	371	1	478	84	0.149466192170818	TRUE	TRUE
ENSG00000130643.9	.	BCM	GRCh38.p13	chr10	133324561	133324561	+	T	T	G	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000130643.9	ENST00000252939.9:c.*1034A>C	.	.	10q26.3	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CALY	34	2	57	8	0.123076923076923	TRUE	NA
ENSG00000137707.13	.	BCM	GRCh38.p13	chr11	111497105	111497105	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000137707.13	.	.	.	11q23.1	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BTG4	11	0	64	9	0.123287671232877	TRUE	NA
ENSG00000258561.2	.	BCM	GRCh38.p13	chr14	66496294	66496294	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000258561.2	.	.	.	14q23.3	C3N-00518	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL359232.1	190	0	426	36	0.0779220779220779	TRUE	NA
ENSG00000117713.20	.	BCM	GRCh38.p13	chr1	26773456	26773456	+	C	C	T	Nonsense_Mutation	SNP	ENST00000324856.13	exon15	c.C3826T	p.R1276X	exonic	ENSG00000117713.20	.	stopgain	ENSG00000117713.20:ENST00000324856.13:exon15:c.C3826T:p.R1276X	1p36.11	C3N-03840	.	.	.	.	.	.	.	.	.	6.7	.	.	.	.	D	D	.	.	.	0.983	.	.	.	.	.	.	.	.	.	D	D	D	.	7.063	37	0.997	D	N	0.962	12.760	0.780	9.555	1.000	0.722	0.702	0.702	0.735	.	4.720	3.740	1.133	1.026	0.599	0.974	1.000	1.000	412	.	.	.	ID=COSV61370466;OCCURENCE=1(breast),5(large_intestine),1(central_nervous_system),2(biliary_tract),2(NS),5(haematopoietic_and_lymphoid_tissue),5(stomach),1(soft_tissue),1(kidney),1(urinary_tract),3(pancreas),9(endometrium)	ARID1A	97	0	179	16	0.0820512820512821	TRUE	TRUE
ENSG00000162613.16	.	BCM	GRCh38.p13	chr1	77960196	77960196	+	G	G	A	Missense_Mutation	SNP	ENST00000370768.6	exon16	c.C1564T	p.P522S	exonic	ENSG00000162613.16	.	nonsynonymous SNV	ENSG00000162613.16:ENST00000370768.6:exon16:c.C1564T:p.P522S	1p31.1	C3N-03840	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.378	T	T	T	0.092	.	0.343	0.610	T	T	T	T	D	D	2.489	22.400	0.994	D	D	0.147	3.075	0.342	3.973	1.000	0.672	0.702	0.702	0.711	.	5.600	5.600	9.419	1.176	0.676	1.000	1.000	0.978	707	.	.	.	ID=COSV53935551;OCCURENCE=1(skin)	FUBP1	151	0	310	39	0.111747851002865	TRUE	TRUE
ENSG00000198837.10	.	BCM	GRCh38.p13	chr1	153930328	153930328	+	C	C	T	Missense_Mutation	SNP	ENST00000361217.9	exon28	c.G4460A	p.R1487Q	exonic	ENSG00000198837.10	.	nonsynonymous SNV	ENSG00000198837.10:ENST00000361217.9:exon28:c.G4460A:p.R1487Q	1q21.3	C3N-03840	8.33e-06	0	0	0	0	1.507e-05	0	0	rs759874404	13.20	D	D	D	P	D	D	M	T	D	0.726	T	T	D	0.319	0.495	0.371	1.881	T	T	D	T	D	D	4.104	27.800	0.999	D	D	0.627	6.212	0.579	5.975	1.000	0.722	0.702	0.636	0.735	.	5.140	4.230	6.815	1.026	0.599	1.000	0.997	0.998	46	.	.	.	ID=COSV63411501;OCCURENCE=1(large_intestine)	DENND4B	143	0	289	62	0.176638176638177	TRUE	TRUE
ENSG00000198216.12	.	BCM	GRCh38.p13	chr1	181724514	181724514	+	G	G	A	Missense_Mutation	SNP	ENST00000367573.7	exon17	c.G2119A	p.A707T	exonic	ENSG00000198216.12	.	nonsynonymous SNV	ENSG00000198216.12:ENST00000367573.7:exon17:c.G2119A:p.A707T	1q25.3	C3N-03840	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	L	D	D	0.815	D	D	D	0.697	0.426	0.938	1.616	D	D	D	D	D	D	3.549	24.900	0.996	D	D	0.608	6.002	0.559	5.744	1.000	0.563	0.654	0.602	0.564	.	4.860	4.860	9.728	1.176	0.674	1.000	0.920	0.282	606	Ion_transport_domain	.	.	.	CACNA1E	250	0	438	41	0.0855949895615866	TRUE	NA
ENSG00000171094.18	.	BCM	GRCh38.p13	chr2	29920460	29920460	+	T	T	C	Missense_Mutation	SNP	ENST00000389048.8	exon1	c.A200G	p.Y67C	exonic	ENSG00000171094.18	.	nonsynonymous SNV	ENSG00000171094.18:ENST00000389048.8:exon1:c.A200G:p.Y67C	2p23.1	C3N-03840	.	.	.	.	.	.	.	.	.	11.19	D	D	D	P	.	D	N	D	N	0.616	D	D	D	0.249	0.362	0.783	0.788	T	T	D	D	D	T	4.213	28.800	0.998	N	N	0.396	4.317	0.429	4.571	0.999	0.598	0.590	0.607	0.639	.	5.360	5.360	1.752	1.062	0.576	1.000	0.981	0.983	817	.	.	.	.	ALK	238	0	415	44	0.0958605664488017	TRUE	TRUE
ENSG00000115896.16	.	BCM	GRCh38.p13	chr2	198084692	198084692	+	A	A	C	Missense_Mutation	SNP	ENST00000428675.6	exon2	c.A1175C	p.E392A	exonic	ENSG00000115896.16	.	nonsynonymous SNV	ENSG00000115896.16:ENST00000428675.6:exon2:c.A1175C:p.E392A	2q33.1	C3N-03840	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	D	0.592	T	T	T	0.099	0.496	0.501	0.430	T	T	T	T	D	D	2.551	22.500	0.980	D	N	0.130	3.005	0.298	3.707	0.033	0.638	0.588	0.547	0.668	.	5.940	5.940	4.869	1.312	0.756	1.000	1.000	1.000	716	.	.	.	.	PLCL1	100	0	163	15	0.0842696629213483	TRUE	TRUE
ENSG00000163513.19	.	BCM	GRCh38.p13	chr3	30674108	30674108	+	G	G	C	Missense_Mutation	SNP	ENST00000295754.10	exon5	c.G1258C	p.G420R	exonic	ENSG00000163513.19	.	nonsynonymous SNV	ENSG00000163513.19:ENST00000295754.10:exon5:c.G1258C:p.G420R	3p24.1	C3N-03840	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.987	D	D	D	0.825	0.948	0.968	1.617	D	D	D	D	D	D	4.365	31	0.999	D	D	1.153	20.237	1.081	25.025	1.000	0.722	0.590	0.609	0.735	.	5.980	5.980	10.003	1.176	0.674	1.000	1.000	0.988	925	Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	TGFBR2	275	1	413	62	0.130526315789474	TRUE	TRUE
ENSG00000180767.10	.	BCM	GRCh38.p13	chr3	126542172	126542172	+	G	G	A	Missense_Mutation	SNP	ENST00000319340.7	exon3	c.G620A	p.R207H	exonic	ENSG00000180767.10	.	nonsynonymous SNV	ENSG00000180767.10:ENST00000319340.7:exon3:c.G620A:p.R207H	3q21.3	C3N-03840	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	U	D	M	T	D	0.376	D	D	D	0.583	0.590	0.846	1.905	D	T	T	T	D	T	3.774	25.700	0.998	D	D	0.367	4.143	0.252	3.449	1.000	0.701	0.590	0.717	0.639	.	4.570	3.670	5.439	1.037	0.524	1.000	0.298	0.046	840	.	.	.	.	CHST13	82	0	229	26	0.101960784313725	TRUE	TRUE
ENSG00000144893.12	.	BCM	GRCh38.p13	chr3	151411447	151411447	+	C	C	T	Missense_Mutation	SNP	ENST00000474524.5	exon39	c.C5975T	p.P1992L	exonic	ENSG00000144893.12	.	nonsynonymous SNV	ENSG00000144893.12:ENST00000474524.5:exon39:c.C5975T:p.P1992L	3q25.1	C3N-03840	8.24e-06	0	0	0	0	1.499e-05	0	0	rs766967153	13.20	D	T	D	D	D	D	M	T	D	0.663	T	T	D	0.249	0.375	0.151	1.234	T	D	T	T	D	D	3.928	26.500	0.999	D	D	0.762	8.087	0.744	8.663	1.000	0.615	0.563	0.659	0.564	.	5.750	5.750	5.553	1.026	0.599	1.000	0.959	0.991	862	Mediator_complex,_subunit_Med12,_catenin-binding	.	.	ID=COSV56379954;OCCURENCE=1(large_intestine),1(stomach)	MED12L	303	0	557	95	0.145705521472393	TRUE	TRUE
ENSG00000183654.9	.	BCM	GRCh38.p13	chr5	16067749	16067749	+	G	G	A	Missense_Mutation	SNP	ENST00000332432.9	exon4	c.C931T	p.R311C	exonic	ENSG00000183654.9	.	nonsynonymous SNV	ENSG00000183654.9:ENST00000332432.9:exon4:c.C931T:p.R311C	5p15.1	C3N-03840	.	.	.	.	.	.	.	.	rs921889840	15.20	D	D	D	D	D	D	L	T	D	0.872	T	T	D	0.516	0.660	0.861	1.329	D	T	D	D	D	D	4.392	31	0.999	D	D	0.802	8.814	0.790	9.825	1.000	0.554	0.489	0.602	0.564	.	5.540	5.540	6.076	1.176	0.676	1.000	0.998	0.996	862	.	.	.	ID=COSV60127080;OCCURENCE=1(large_intestine)	MARCHF11	176	0	301	38	0.112094395280236	TRUE	TRUE
ENSG00000106113.19	.	BCM	GRCh38.p13	chr7	30655074	30655074	+	A	A	G	Missense_Mutation	SNP	ENST00000471646.6	exon11	c.T1060C	p.F354L	exonic	ENSG00000106113.19	.	nonsynonymous SNV	ENSG00000106113.19:ENST00000471646.6:exon11:c.T1060C:p.F354L	7p14.3	C3N-03840	.	.	.	.	.	.	.	.	.	11.20	D	T	D	P	D	D	L	T	N	0.904	T	T	T	0.308	0.684	0.604	0.440	D	T	D	D	D	D	3.894	26.300	0.998	D	D	0.458	4.724	0.527	5.413	1.000	0.554	0.588	0.602	0.568	.	5.290	5.290	8.746	1.207	0.756	1.000	0.998	0.989	695	GPCR,_family_2-like;GPCR,_family_2,_secretin-like,_conserved_site	.	.	.	CRHR2	165	0	334	33	0.0899182561307902	TRUE	TRUE
ENSG00000165124.18	.	BCM	GRCh38.p13	chr9	110406671	110406671	+	G	G	A	Missense_Mutation	SNP	ENST00000374469.6	exon38	c.C8929T	p.P2977S	exonic	ENSG00000165124.18	.	nonsynonymous SNV	ENSG00000165124.18:ENST00000374469.6:exon38:c.C8929T:p.P2977S	9q31.3	C3N-03840	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	D	0.150	T	T	T	0.131	0.569	0.155	0.104	T	T	T	T	T	T	1.701	17.030	0.913	D	N	-0.542	1.095	-0.454	1.278	0.000	0.554	0.563	0.618	0.564	.	5.570	-1.070	1.361	0.161	0.616	1.000	0.995	0.998	969	Sushi/SCR/CCP_domain	.	.	.	SVEP1	181	0	367	41	0.100490196078431	TRUE	TRUE
ENSG00000136848.17	.	BCM	GRCh38.p13	chr9	121772954	121772954	+	C	C	T	Missense_Mutation	SNP	ENST00000408936.7	exon12	c.C2426T	p.T809I	exonic	ENSG00000136848.17	.	nonsynonymous SNV	ENSG00000136848.17:ENST00000408936.7:exon12:c.C2426T:p.T809I	9q33.2	C3N-03840	.	.	.	.	.	.	.	.	.	10.20	D	T	P	P	D	D	M	T	N	0.567	T	T	D	0.135	0.224	0.196	0.418	D	T	T	T	D	D	2.254	21.300	0.998	D	D	0.334	3.958	0.383	4.239	1.000	0.696	0.610	0.723	0.636	.	4.690	4.690	7.347	1.026	0.599	1.000	0.997	0.985	950	Domain_of_unknown_function_DUF3498	.	.	.	DAB2IP	68	0	108	17	0.136	TRUE	TRUE
ENSG00000099834.19	.	BCM	GRCh38.p13	chr11	621349	621349	+	A	A	G	Missense_Mutation	SNP	ENST00000397542.7	exon6	c.T614C	p.V205A	exonic	ENSG00000099834.19	.	nonsynonymous SNV	ENSG00000099834.19:ENST00000397542.7:exon6:c.T614C:p.V205A	11p15.5	C3N-03840	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.391	T	T	T	0.223	0.681	0.014	0.048	T	T	T	T	T	T	-0.192	0.532	0.658	N	N	-1.477	0.089	-1.415	0.144	0.961	0.581	0.759	0.537	0.605	.	4.190	-2.220	-0.631	-1.567	-2.049	0.000	0.040	0.003	929	Cadherin-like	.	.	.	CDHR5	123	0	235	26	0.0996168582375479	TRUE	TRUE
ENSG00000149311.18	.	BCM	GRCh38.p13	chr11	108353856	108353856	+	C	C	G	Missense_Mutation	SNP	ENST00000278616.8	exon60	c.C8762G	p.T2921R	exonic	ENSG00000149311.18	.	nonsynonymous SNV	ENSG00000149311.18:ENST00000278616.8:exon60:c.C8762G:p.T2921R	11q22.3	C3N-03840	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.973	D	D	D	0.824	0.711	0.959	0.620	D	D	D	D	D	D	4.034	27.200	0.993	D	D	0.931	11.891	0.871	12.581	1.000	0.707	0.725	0.725	0.714	.	5.420	5.420	7.900	1.026	0.599	1.000	0.986	0.955	193	Phosphatidylinositol_3-/4-kinase,_catalytic_domain	.	.	.	ATM	397	0	578	68	0.105263157894737	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-03840	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	248	0	386	56	0.126696832579186	TRUE	TRUE
ENSG00000156222.12	.	BCM	GRCh38.p13	chr15	84943464	84943464	+	C	C	T	Missense_Mutation	SNP	ENST00000394573.6	exon16	c.C1601T	p.T534M	exonic	ENSG00000156222.12	.	nonsynonymous SNV	ENSG00000156222.12:ENST00000394573.6:exon16:c.C1601T:p.T534M	15q25.3	C3N-03840	4.119e-05	0	8.643e-05	0	0	5.994e-05	0	0	rs145160651	10.20	D	D	D	D	D	D	L	T	D	0.751	T	T	T	0.170	.	0.480	0.423	T	T	T	T	T	D	3.441	24.500	0.997	D	D	-0.161	1.989	-0.246	1.679	0.950	0.554	0.590	0.618	0.567	.	4.200	2.290	2.931	1.006	0.599	0.987	0.544	0.147	628	Concentrative_nucleoside_transporter_C-terminal_domain	.	.	.	SLC28A1	384	1	674	66	0.0891891891891892	TRUE	NA
ENSG00000162039.15	.	BCM	GRCh38.p13	chr16	1844951	1844951	+	G	G	A	Missense_Mutation	SNP	ENST00000397344.7	exon10	c.C791T	p.A264V	exonic	ENSG00000162039.15	.	nonsynonymous SNV	ENSG00000162039.15:ENST00000397344.7:exon10:c.C791T:p.A264V	16p13.3	C3N-03840	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.681	T	T	T	0.324	0.539	0.227	.	T	T	D	D	D	D	3.681	25.300	0.999	D	D	0.786	8.510	0.758	8.991	0.999	0.554	0.574	0.618	0.542	.	5.980	5.980	5.978	1.155	0.616	1.000	0.987	0.908	641	.	.	.	.	MEIOB	36	0	70	7	0.0909090909090909	TRUE	TRUE
ENSG00000006788.14	.	BCM	GRCh38.p13	chr17	10318992	10318992	+	C	C	T	Missense_Mutation	SNP	ENST00000252172.9	exon27	c.G3536A	p.R1179H	exonic	ENSG00000006788.14	.	nonsynonymous SNV	ENSG00000006788.14:ENST00000252172.9:exon27:c.G3536A:p.R1179H	17p13.1	C3N-03840	2.471e-05	9.614e-05	0	0	0	2.997e-05	0	0	rs369467746	16.19	D	D	D	D	.	D	H	D	D	0.725	D	D	T	0.555	.	0.877	0.475	T	D	T	D	D	D	3.867	26.200	0.999	D	D	0.711	7.281	0.571	5.880	0.131	0.487	0.547	0.492	0.564	.	4.050	3.060	6.142	1.022	0.545	1.000	0.981	0.983	86	Myosin_tail	.	.	ID=COSV52840316;OCCURENCE=1(skin)	MYH13	516	0	915	89	0.0886454183266932	NA	TRUE
ENSG00000276234.5	.	BCM	GRCh38.p13	chr17	37476891	37476891	+	C	C	T	Missense_Mutation	SNP	ENST00000615182.5	exon16	c.C1241T	p.A414V	exonic	ENSG00000276234.5	.	nonsynonymous SNV	ENSG00000276234.5:ENST00000615182.5:exon16:c.C1241T:p.A414V	17q12	C3N-03840	8.238e-06	0	0	0.0001	0	0	0	0	rs748285471	7.14	.	D	.	.	D	D	.	.	.	0.567	T	T	T	0.283	0.531	0.662	.	T	T	T	T	D	D	3.969	26.800	0.999	D	D	0.880	10.541	0.860	12.141	1.000	0.731	0.725	0.725	0.649	.	5.930	5.930	7.715	1.026	0.599	1.000	0.999	0.970	53	SWIRM_domain	.	.	.	TADA2A	115	0	200	15	0.0697674418604651	TRUE	NA
ENSG00000120071.14	.	BCM	GRCh38.p13	chr17	46034185	46034185	+	-	NA	GCAGTTTCTCTAC	Frame_Shift_Ins	INS	ENST00000432791.6	exon11	c.2641_2642insGTAGAGAAACTGC	p.Q881Rfs*18	exonic	ENSG00000120071.14	.	frameshift insertion	ENSG00000120071.14:ENST00000432791.6:exon11:c.2641_2642insGTAGAGAAACTGC:p.Q881Rfs*18	17q21.31	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KANSL1	NA	NA	NA	NA	NA	NA	NA
ENSG00000141367.12	.	BCM	GRCh38.p13	chr17	59693805	59693805	+	G	G	A	Missense_Mutation	SNP	ENST00000269122.8	exon32	c.G4981A	p.A1661T	exonic	ENSG00000141367.12	.	nonsynonymous SNV	ENSG00000141367.12:ENST00000269122.8:exon32:c.G4981A:p.A1661T	17q23.1	C3N-03840	.	.	.	.	.	.	.	.	.	9.20	T	T	D	P	D	D	M	T	N	0.683	T	T	T	0.220	0.204	0.551	1.401	D	T	T	T	D	D	2.582	22.600	0.926	D	D	0.598	5.902	0.678	7.356	1.000	0.672	0.702	0.702	0.711	.	5.910	5.910	7.922	1.176	0.676	1.000	1.000	0.967	569	.	.	.	ID=COSV52244627;OCCURENCE=2(large_intestine)	CLTC	125	1	256	15	0.0553505535055351	TRUE	TRUE
ENSG00000130402.12	.	BCM	GRCh38.p13	chr19	38729362	38729362	+	C	C	T	Missense_Mutation	SNP	ENST00000252699.7	exon21	c.C2666T	p.P889L	exonic	ENSG00000130402.12	.	nonsynonymous SNV	ENSG00000130402.12:ENST00000252699.7:exon21:c.C2666T:p.P889L	19q13.2	C3N-03840	.	.	.	.	.	.	.	.	.	11.19	D	D	B	B	D	D	M	T	D	0.484	T	T	D	0.316	0.674	0.806	1.049	T	D	T	T	D	.	2.446	22.300	0.992	D	D	-0.078	2.245	-0.087	2.085	1.000	0.672	0.702	0.607	0.711	.	3.480	3.480	3.861	1.026	0.599	0.996	0.162	0.021	707	EF-hand,_Ca_insensitive	.	.	.	ACTN4	383	0	711	77	0.0977157360406091	TRUE	TRUE
ENSG00000128011.4	.	BCM	GRCh38.p13	chr19	39308036	39308036	+	A	A	G	Missense_Mutation	SNP	ENST00000248668.4	exon2	c.T1913C	p.V638A	exonic	ENSG00000128011.4	.	nonsynonymous SNV	ENSG00000128011.4:ENST00000248668.4:exon2:c.T1913C:p.V638A	19q13.2	C3N-03840	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.023	T	T	D	0.023	0.372	0.185	.	T	T	T	T	T	T	0.071	1.842	0.582	N	N	-1.290	0.170	-1.305	0.206	1.000	0.726	0.588	0.594	0.621	.	4.070	-0.716	-0.863	0.241	0.636	0.000	0.011	0.088	560	.	.	.	.	LRFN1	46	0	78	11	0.123595505617978	TRUE	TRUE
ENSG00000242019.1	.	BCM	GRCh38.p13	chr19	54727671	54727671	+	C	C	T	Missense_Mutation	SNP	ENST00000291860.1	exon4	c.C416T	p.T139M	exonic	ENSG00000242019.1	.	nonsynonymous SNV	ENSG00000242019.1:ENST00000291860.1:exon4:c.C416T:p.T139M	19q13.42	C3N-03840	3.823e-05	0.0002	0	0	0	3.157e-05	0	0	rs544733307	2.15	T	D	.	.	N	N	.	T	D	0.129	T	T	T	0.111	0.367	0.043	1.964	T	.	T	T	T	.	-1.144	0.003	0.755	N	N	-1.171	0.248	-1.464	0.122	0.000	0.487	0.574	0.574	0.564	.	1.500	-3.010	-2.607	-2.491	-2.345	0.000	0.000	0.000	952	Immunoglobulin_subtype	.	.	ID=COSV52546043;OCCURENCE=1(breast),1(ovary)	KIR3DL3	226	0	365	89	0.196035242290749	TRUE	TRUE
ENSG00000215595.2	.	BCM	GRCh38.p13	chr20	1207085	1207085	+	C	C	T	Nonsense_Mutation	SNP	ENST00000400633.2	exon2	c.C352T	p.R118X	exonic	ENSG00000215595.2	.	stopgain	ENSG00000215595.2:ENST00000400633.2:exon2:c.C352T:p.R118X	20p13	C3N-03840	8.737e-05	0	0	0	0	0.0002	0	0	rs181425626	3.5	.	.	.	.	.	N	.	.	.	0.127	.	.	.	.	.	.	.	.	.	D	D	.	.	7.387	38	0.997	D	N	0.634	6.293	0.458	4.798	0.991	0.554	0.563	0.602	0.530	.	3.760	3.760	0.647	0.097	-0.233	0.961	0.997	0.966	922	.	.	.	ID=COSV68763753;OCCURENCE=1(large_intestine),1(prostate)	C20orf202	56	0	94	6	0.06	TRUE	TRUE
ENSG00000198646.14	.	BCM	GRCh38.p13	chr20	34749420	34749420	+	-	NA	T	Frame_Shift_Ins	INS	ENST00000359003.7	exon9	c.2774dupA	p.N925Kfs*2	exonic	ENSG00000198646.14	.	frameshift insertion	ENSG00000198646.14:ENST00000359003.7:exon9:c.2774dupA:p.N925Kfs*2	20q11.22	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NCOA6	NA	NA	NA	NA	NA	NA	NA
ENSG00000100393.14	.	BCM	GRCh38.p13	chr22	41117357	41117357	+	A	A	G	Missense_Mutation	SNP	ENST00000263253.9	exon2	c.A265G	p.S89G	exonic	ENSG00000100393.14	.	nonsynonymous SNV	ENSG00000100393.14:ENST00000263253.9:exon2:c.A265G:p.S89G	22q13.2	C3N-03840	.	.	.	.	.	.	.	.	.	14.20	D	T	D	P	D	D	M	D	N	0.578	D	D	D	0.371	0.152	0.817	.	T	D	D	T	D	D	3.660	25.300	0.998	D	N	0.663	6.630	0.681	7.417	1.000	0.707	0.696	0.702	0.714	.	5.990	5.990	5.848	1.312	0.756	1.000	1.000	0.999	296	.	.	.	.	EP300	320	0	548	55	0.0912106135986733	TRUE	TRUE
ENSG00000169306.10	.	BCM	GRCh38.p13	chrX	29955440	29955440	+	C	C	A	Missense_Mutation	SNP	ENST00000378993.6	exon11	c.C1711A	p.Q571K	exonic	ENSG00000169306.10	.	nonsynonymous SNV	ENSG00000169306.10:ENST00000378993.6:exon11:c.C1711A:p.Q571K	Xp21.2	C3N-03840	1.161e-05	0	0	0	0	0	0	0.0001	rs756892831	5.19	T	T	B	B	D	D	L	T	N	0.134	T	T	D	0.115	0.495	0.490	1.102	T	T	T	T	T	D	2.161	20.600	0.958	D	.	.	.	.	.	1.000	.	.	.	.	.	5.250	5.250	7.568	1.026	0.599	1.000	1.000	0.999	491	.	.	.	ID=COSV100148575;OCCURENCE=1(lung)	IL1RAPL1	265	0	418	36	0.079295154185022	TRUE	NA
ENSG00000118997.14	.	BCM	GRCh38.p13	chr2	195875805	195875805	+	C	C	T	Silent	SNP	ENST00000312428.11	exon38	c.G6156A	p.E2052E	exonic	ENSG00000118997.14	.	synonymous SNV	ENSG00000118997.14:ENST00000312428.11:exon38:c.G6156A:p.E2052E	2q32.3	C3N-03840	8.374e-06	0.0001	0	0	0	0	0	0	rs370194780	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH7	90	0	163	22	0.118918918918919	TRUE	NA
ENSG00000163781.14	.	BCM	GRCh38.p13	chr3	133608583	133608583	+	C	C	T	Silent	SNP	ENST00000260810.10	exon27	c.G4377A	p.Q1459Q	exonic	ENSG00000163781.14	.	synonymous SNV	ENSG00000163781.14:ENST00000260810.10:exon27:c.G4377A:p.Q1459Q	3q22.1	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99604876;OCCURENCE=1(cervix)	TOPBP1	153	1	249	30	0.10752688172043	TRUE	TRUE
ENSG00000083857.14	.	BCM	GRCh38.p13	chr4	186603312	186603312	+	G	G	A	Silent	SNP	ENST00000441802.7	exon19	c.C11214T	p.C3738C	exonic	ENSG00000083857.14	.	synonymous SNV	ENSG00000083857.14:ENST00000441802.7:exon19:c.C11214T:p.C3738C	4q35.2	C3N-03840	8.299e-06	0	0	0	0	0	0	6.066e-05	rs562587924	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAT1	336	1	645	63	0.0889830508474576	TRUE	NA
ENSG00000176788.9	.	BCM	GRCh38.p13	chr5	17275786	17275786	+	G	G	A	Silent	SNP	ENST00000322611.4	exon2	c.G570A	p.T190T	exonic	ENSG00000176788.9	.	synonymous SNV	ENSG00000176788.9:ENST00000322611.4:exon2:c.G570A:p.T190T	5p15.1	C3N-03840	2.755e-05	0	0.0003	0	0	0	0	0	rs759514967	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BASP1	181	0	281	36	0.113564668769716	TRUE	NA
ENSG00000261150.3	.	BCM	GRCh38.p13	chr8	143871037	143871037	+	G	G	A	Silent	SNP	ENST00000615648.2	exon2	c.C2217T	p.P739P	exonic	ENSG00000261150.3	.	synonymous SNV	ENSG00000261150.3:ENST00000615648.2:exon2:c.C2217T:p.P739P	8q24.3	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EPPK1	277	0	528	64	0.108108108108108	TRUE	NA
ENSG00000167566.17	.	BCM	GRCh38.p13	chr12	49796465	49796465	+	C	C	T	Silent	SNP	ENST00000335999.7	exon8	c.G1395A	p.S465S	exonic	ENSG00000167566.17	.	synonymous SNV	ENSG00000167566.17:ENST00000335999.7:exon8:c.G1395A:p.S465S	12q13.12	C3N-03840	1.297e-05	0.0002	0	0	0	0	0	0	rs548007920	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NCKAP5L	21	0	40	7	0.148936170212766	TRUE	NA
ENSG00000186184.19	.	BCM	GRCh38.p13	chr13	27622007	27622007	+	G	G	A	Silent	SNP	ENST00000302979.5	exon1	c.G24A	p.E8E	exonic	ENSG00000186184.19	.	synonymous SNV	ENSG00000186184.19:ENST00000302979.5:exon1:c.G24A:p.E8E	13q12.2	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	POLR1D	304	0	509	49	0.0878136200716846	TRUE	NA
ENSG00000103184.12	.	BCM	GRCh38.p13	chr16	5008549	5008549	+	C	C	T	Silent	SNP	ENST00000251170.12	exon14	c.C1701T	p.T567T	exonic	ENSG00000103184.12	.	synonymous SNV	ENSG00000103184.12:ENST00000251170.12:exon14:c.C1701T:p.T567T	16p13.3	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEC14L5	105	0	216	24	0.1	TRUE	TRUE
ENSG00000157423.18	.	BCM	GRCh38.p13	chr16	70920906	70920906	+	C	C	T	Silent	SNP	ENST00000393567.7	exon46	c.G7470A	p.A2490A	exonic	ENSG00000157423.18	.	synonymous SNV	ENSG00000157423.18:ENST00000393567.7:exon46:c.G7470A:p.A2490A	16q22.2	C3N-03840	4.761e-05	0	0	0	0	3.469e-05	0	0.0002	rs1798530	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99992190;OCCURENCE=1(large_intestine),1(endometrium)	HYDIN	213	0	372	35	0.085995085995086	NA	TRUE
ENSG00000166377.20	.	BCM	GRCh38.p13	chr18	79277180	79277180	+	A	A	G	Silent	SNP	ENST00000426216.6	exon13	c.A1395G	p.L465L	exonic	ENSG00000166377.20	.	synonymous SNV	ENSG00000166377.20:ENST00000426216.6:exon13:c.A1395G:p.L465L	18q23	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP9B	131	0	172	28	0.14	TRUE	TRUE
ENSG00000198646.14	.	BCM	GRCh38.p13	chr20	34749618	34749618	+	T	T	G	Silent	SNP	ENST00000359003.7	exon9	c.A2577C	p.G859G	exonic	ENSG00000198646.14	.	synonymous SNV	ENSG00000198646.14:ENST00000359003.7:exon9:c.A2577C:p.G859G	20q11.22	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NCOA6	118	1	205	32	0.135021097046413	TRUE	NA
ENSG00000149527.18	.	BCM	GRCh38.p13	chr1	2502416	2502416	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000149527.18	.	.	.	1p36.32	C3N-03840	.	.	.	.	.	.	.	.	.	2.15	T	T	B	B	.	D	.	T	N	0.112	T	T	D	0.015	0.183	0.061	0.233	.	.	T	T	T	.	0.147	2.540	0.980	N	N	-1.103	0.304	-1.127	0.348	0.801	0.421	0.551	0.514	0.563	.	4.370	1.330	0.266	-0.240	-0.254	0.037	0.140	0.129	829	.	.	.	ID=COSV53939907;OCCURENCE=1(large_intestine)	PLCH2	315	0	574	68	0.105919003115265	TRUE	NA
ENSG00000073737.16	.	BCM	GRCh38.p13	chr2	169067238	169067238	+	A	A	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000073737.16	.	.	.	2q31.1	C3N-03840	.	.	.	.	.	.	.	.	.	3.13	D	.	.	.	.	N	.	D	N	0.164	T	T	D	0.134	0.280	0.287	.	.	.	T	T	T	T	0.943	10.920	0.846	N	N	-1.065	0.339	-1.150	0.327	1.000	0.487	0.574	0.492	0.613	.	3.350	0.807	0.380	0.283	-0.100	0.000	0.006	0.004	810	.	.	.	.	DHRS9	147	0	283	32	0.101587301587302	TRUE	TRUE
ENSG00000181001.2	.	BCM	GRCh38.p13	chr11	5796581	5796581	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000181001.2;ENSG00000236965.4	dist=5316;dist=3783	.	.	11p15.4	C3N-03840	.	.	.	.	.	.	.	.	rs945377486	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66206099;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	OR52N1	318	0	533	52	0.0888888888888889	TRUE	NA
ENSG00000170004.17	.	BCM	GRCh38.p13	chr17	7910425	7910425	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000170004.17	.	.	.	17p13.1	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHD3	470	0	798	89	0.100338218714769	TRUE	NA
ENSG00000225950.8	.	BCM	GRCh38.p13	chr19	49061364	49061364	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000225950.8	ENST00000593537.1:c.*1G>A	.	.	19q13.33	C3N-03840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NTF4	246	0	476	45	0.0863723608445297	TRUE	NA
ENSG00000163554.15	.	BCM	GRCh38.p13	chr1	158647692	158647692	+	C	C	T	Missense_Mutation	SNP	ENST00000643759.2	exon27	c.G3743A	p.R1248Q	exonic	ENSG00000163554.15	.	nonsynonymous SNV	ENSG00000163554.15:ENST00000643759.2:exon27:c.G3743A:p.R1248Q	1q23.1	C3L-02606	1.664e-05	0	0.0002	0	0	0	0	0	rs568044940	12.20	D	D	D	D	N	D	M	T	D	0.322	T	T	D	0.219	0.419	0.775	0.050	T	T	T	T	D	D	3.106	23.600	0.999	D	D	0.263	3.596	0.101	2.739	1.000	0.554	0.547	0.574	0.621	.	4.710	3.800	4.761	1.026	0.599	1.000	0.174	0.606	603	.	.	.	ID=COSV63753987;OCCURENCE=1(large_intestine)	SPTA1	196	0	416	73	0.149284253578732	TRUE	TRUE
ENSG00000135835.12	.	BCM	GRCh38.p13	chr1	180935272	180935272	+	G	G	T	Nonsense_Mutation	SNP	ENST00000367588.9	exon5	c.G1363T	p.E455X	exonic	ENSG00000135835.12	.	stopgain	ENSG00000135835.12:ENST00000367588.9:exon5:c.G1363T:p.E455X	1q25.3	C3L-02606	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.190	.	.	.	.	.	.	.	.	.	D	D	.	.	7.274	37	0.997	D	N	0.900	11.046	0.697	7.693	1.000	0.609	0.492	0.769	0.568	.	4.830	4.830	7.054	1.172	0.674	1.000	0.926	0.423	865	Domain_of_unknown_function_DUF4685	.	.	.	KIAA1614	18	0	56	5	0.0819672131147541	TRUE	TRUE
ENSG00000162951.11	.	BCM	GRCh38.p13	chr2	80303720	80303720	+	C	C	T	Missense_Mutation	SNP	ENST00000295057.4	exon2	c.G100A	p.A34T	exonic	ENSG00000162951.11	.	nonsynonymous SNV	ENSG00000162951.11:ENST00000295057.4:exon2:c.G100A:p.A34T	2p12	C3L-02606	.	.	.	.	.	.	.	.	.	5.20	D	T	P	B	U	D	N	T	N	0.355	T	T	D	0.089	0.227	0.307	.	T	T	T	T	T	T	2.393	22.100	0.984	D	D	0.023	2.595	0.054	2.554	1.000	0.497	0.590	0.504	0.563	.	4.650	4.650	3.398	1.010	0.529	1.000	1.000	0.998	948	.	.	.	ID=COSV99703402;OCCURENCE=1(stomach)	LRRTM1	44	0	145	26	0.152046783625731	TRUE	NA
ENSG00000239305.7	.	BCM	GRCh38.p13	chr2	86604703	86604703	+	T	T	C	Missense_Mutation	SNP	ENST00000237455.5	exon4	c.A1198G	p.T400A	exonic	ENSG00000239305.7	.	nonsynonymous SNV	ENSG00000239305.7:ENST00000237455.5:exon4:c.A1198G:p.T400A	2p11.2	C3L-02606	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	D	D	L	T	N	0.838	T	T	D	0.306	0.346	0.643	0.767	T	T	D	D	D	D	3.809	25.900	0.993	D	D	0.723	7.453	0.721	8.158	1.000	0.707	0.725	0.659	0.714	.	5.590	5.590	7.722	1.138	0.609	1.000	1.000	0.997	603	.	.	.	ID=COSV52896064;OCCURENCE=1(endometrium)	RNF103	220	0	338	77	0.185542168674699	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178587208	178587208	+	C	C	T	Missense_Mutation	SNP	ENST00000591111.5	exon257	c.G59080A	p.E19694K	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon257:c.G59080A:p.E19694K	2q31.2	C3L-02606	8.29e-06	0.0001	0	0	0	0	0	0	rs773791222	9.17	D	.	D	D	.	D	L	T	D	0.814	T	T	T	0.362	.	0.315	0.489	T	.	T	T	D	D	3.323	24.200	0.993	D	D	0.751	7.893	0.782	9.603	1.000	0.476	0.602	0.547	0.504	.	5.980	5.980	6.106	1.026	0.599	1.000	1.000	0.999	405	Fibronectin_type_III	.	.	.	TTN	365	1	722	164	0.18510158013544	TRUE	NA
ENSG00000206557.6	.	BCM	GRCh38.p13	chr3	32818300	32818300	+	C	C	T	Missense_Mutation	SNP	ENST00000383763.6	exon1	c.C220T	p.R74W	exonic	ENSG00000206557.6	.	nonsynonymous SNV	ENSG00000206557.6:ENST00000383763.6:exon1:c.C220T:p.R74W	3p22.3	C3L-02606	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	U	D	N	D	N	0.502	T	T	D	0.436	0.703	0.282	0.993	D	T	T	T	D	T	3.915	26.400	0.995	D	N	-0.035	2.390	-0.035	2.242	1.000	0.598	0.492	0.391	0.639	.	4.010	1.970	1.263	0.853	0.500	1.000	0.999	0.931	735	Zinc_finger,_RING-type	.	.	.	TRIM71	192	0	320	87	0.213759213759214	TRUE	TRUE
ENSG00000182168.15	.	BCM	GRCh38.p13	chr4	95242515	95242515	+	G	G	A	Missense_Mutation	SNP	ENST00000453304.6	exon7	c.C1022T	p.T341M	exonic	ENSG00000182168.15	.	nonsynonymous SNV	ENSG00000182168.15:ENST00000453304.6:exon7:c.C1022T:p.T341M	4q22.3	C3L-02606	1.842e-05	0	0	0	0	3.371e-05	0	0	rs775796452	8.20	T	T	D	P	N	D	M	T	D	0.343	T	T	D	0.184	.	0.856	0.237	T	T	T	T	D	D	2.858	23.100	0.992	D	N	0.293	3.746	0.317	3.816	0.998	0.554	0.574	0.618	0.621	.	5.100	5.100	1.734	1.176	0.676	0.970	0.526	0.470	567	.	.	.	ID=COSV71661666;OCCURENCE=3(large_intestine),1(stomach)	UNC5C	115	0	296	27	0.0835913312693498	TRUE	TRUE
ENSG00000255408.4	.	BCM	GRCh38.p13	chr5	140801300	140801300	+	G	G	A	Missense_Mutation	SNP	ENST00000522353.3	exon1	c.G103A	p.V35I	exonic	ENSG00000255408.4	.	nonsynonymous SNV	ENSG00000255408.4:ENST00000522353.3:exon1:c.G103A:p.V35I	5q31.3	C3L-02606	.	.	.	.	.	.	.	.	.	1.19	T	T	P	B	N	D	N	T	N	0.121	T	T	T	0.064	0.594	0.145	.	.	T	T	T	T	T	1.438	15.340	0.840	N	N	-0.759	0.717	-0.817	0.734	0.908	0.534	0.574	0.686	0.555	.	4.650	1.870	0.019	0.210	0.618	0.001	0.015	0.153	18	Cadherin,_N-terminal	.	.	ID=COSV65366871;OCCURENCE=1(breast),1(large_intestine)	PCDHA3	317	0	644	87	0.119015047879617	NA	TRUE
ENSG00000204965.9	.	BCM	GRCh38.p13	chr5	140823693	140823693	+	G	G	A	Missense_Mutation	SNP	ENST00000529859.2	exon1	c.G1918A	p.E640K	exonic	ENSG00000204965.9	.	nonsynonymous SNV	ENSG00000204965.9:ENST00000529859.2:exon1:c.G1918A:p.E640K	5q31.3	C3L-02606	.	.	.	.	.	.	.	.	.	8.18	D	D	P	B	.	D	L	T	D	0.201	T	T	D	0.233	0.762	0.769	0.427	.	T	T	T	D	T	2.951	23.300	0.999	D	D	0.251	3.534	0.315	3.808	1.000	0.581	0.574	0.576	0.542	.	4.010	4.010	4.545	1.072	0.522	0.998	0.435	0.041	28	Cadherin-like	.	.	.	PCDHA5	314	0	629	59	0.0857558139534884	TRUE	TRUE
ENSG00000253731.3	.	BCM	GRCh38.p13	chr5	141375105	141375105	+	A	A	G	Missense_Mutation	SNP	ENST00000517434.3	exon1	c.A1022G	p.N341S	exonic	ENSG00000253731.3	.	nonsynonymous SNV	ENSG00000253731.3:ENST00000517434.3:exon1:c.A1022G:p.N341S	5q31.3	C3L-02606	4.975e-05	0	0	0.0007	0	0	0	0	rs371346343	16.19	D	D	D	D	U	D	H	D	D	0.799	D	D	D	0.787	0.734	0.987	0.862	.	T	T	D	D	D	4.007	27.000	0.999	D	D	1.027	14.785	0.933	15.260	1.000	0.554	0.588	0.576	0.621	.	5.250	5.250	9.325	1.312	0.756	1.000	1.000	0.999	651	Cadherin-like	.	.	ID=COSV54018804;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	PCDHGA6	251	0	495	82	0.1421143847487	TRUE	TRUE
ENSG00000086570.12	.	BCM	GRCh38.p13	chr5	151565735	151565735	+	T	T	G	Missense_Mutation	SNP	ENST00000261800.5	exon1	c.A3197C	p.E1066A	exonic	ENSG00000086570.12	.	nonsynonymous SNV	ENSG00000086570.12:ENST00000261800.5:exon1:c.A3197C:p.E1066A	5q33.1	C3L-02606	.	.	.	.	.	.	.	.	.	6.20	D	T	P	P	D	D	L	T	D	0.562	T	T	T	0.110	0.417	0.655	0.371	T	T	T	T	D	T	3.731	25.500	0.994	D	N	0.320	3.883	0.346	3.996	1.000	0.487	0.590	0.574	0.542	.	5.160	3.920	3.155	1.138	0.665	0.998	0.973	0.838	903	Cadherin-like	.	.	.	FAT2	132	0	327	27	0.076271186440678	TRUE	TRUE
ENSG00000168269.10	.	BCM	GRCh38.p13	chr5	170106177	170106177	+	C	C	G	Missense_Mutation	SNP	ENST00000306268.8	exon1	c.C220G	p.P74A	exonic	ENSG00000168269.10	.	nonsynonymous SNV	ENSG00000168269.10:ENST00000306268.8:exon1:c.C220G:p.P74A	5q35.1	C3L-02606	.	.	.	.	.	.	.	.	.	12.20	D	T	B	B	D	D	M	D	D	0.363	D	D	D	0.312	0.320	0.928	0.267	T	D	T	T	D	T	1.416	15.190	0.994	D	N	-0.225	1.808	-0.165	1.871	0.997	0.497	0.590	0.578	0.613	.	5.060	4.170	2.690	1.026	0.549	0.978	0.629	0.032	952	.	.	.	.	FOXI1	68	0	243	18	0.0689655172413793	TRUE	TRUE
ENSG00000145982.13	.	BCM	GRCh38.p13	chr6	5368853	5368853	+	G	G	A	Missense_Mutation	SNP	ENST00000274680.9	exon2	c.G283A	p.E95K	exonic	ENSG00000145982.13	.	nonsynonymous SNV	ENSG00000145982.13:ENST00000274680.9:exon2:c.G283A:p.E95K	6p25.1	C3L-02606	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	L	T	N	0.228	T	T	T	0.062	0.495	0.680	0.177	T	T	T	T	D	D	2.288	21.500	0.996	D	D	-0.271	1.687	-0.113	2.012	0.060	0.706	0.725	0.710	0.714	.	5.330	2.300	4.417	1.176	0.676	1.000	1.000	0.973	944	Phenylalanyl-tRNA_synthetase	.	.	ID=COSV104571843;OCCURENCE=1(skin)	FARS2	417	0	872	153	0.149268292682927	TRUE	TRUE
ENSG00000106327.13	.	BCM	GRCh38.p13	chr7	100627296	100627296	+	C	C	T	Missense_Mutation	SNP	ENST00000223051.8	exon16	c.G1963A	p.G655R	exonic	ENSG00000106327.13	.	nonsynonymous SNV	ENSG00000106327.13:ENST00000223051.8:exon16:c.G1963A:p.G655R	7q22.1	C3L-02606	.	.	.	.	.	.	.	.	rs920217192	6.20	T	T	D	P	N	D	N	T	N	0.529	T	T	D	0.234	0.529	0.718	1.099	T	T	T	T	D	T	3.070	23.600	0.997	D	D	0.152	3.096	0.233	3.351	1.000	0.658	0.435	0.619	0.555	.	5.320	5.320	2.042	0.129	0.599	1.000	0.930	0.944	707	.	.	.	.	TFR2	270	1	766	120	0.135440180586907	TRUE	NA
ENSG00000169871.13	.	BCM	GRCh38.p13	chr7	101088439	101088441	+	AGA	AGA	-	In_Frame_Del	DEL	ENST00000306085.11	exon3	c.1127_1129del	p.K377del	exonic	ENSG00000169871.13	.	nonframeshift deletion	ENSG00000169871.13:ENST00000306085.11:exon3:c.1127_1129del:p.K377del	7q22.1	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIM56	96	0	222	22	0.0901639344262295	TRUE	TRUE
ENSG00000137563.12	.	BCM	GRCh38.p13	chr8	63017526	63017526	+	C	C	T	Missense_Mutation	SNP	ENST00000260118.7	exon8	c.G802A	p.A268T	exonic	ENSG00000137563.12	.	nonsynonymous SNV	ENSG00000137563.12:ENST00000260118.7:exon8:c.G802A:p.A268T	8q12.3	C3L-02606	8.264e-06	0	0	0.0001	0	0	0	0	rs554949020	2.20	T	T	P	B	D	D	L	T	N	0.422	T	T	T	0.123	0.436	0.439	0.124	T	T	T	T	T	T	2.114	20.200	0.967	N	N	-0.217	1.829	-0.107	2.026	0.332	0.732	0.744	0.710	0.728	.	5.680	3.640	1.016	0.074	0.599	0.584	0.996	0.994	921	.	.	.	ID=COSV99479016;OCCURENCE=1(endometrium)	GGH	106	0	293	54	0.155619596541787	TRUE	NA
ENSG00000147852.16	.	BCM	GRCh38.p13	chr9	2646549	2646549	+	C	C	T	Missense_Mutation	SNP	ENST00000382100.8	exon11	c.C1700T	p.S567F	exonic	ENSG00000147852.16	.	nonsynonymous SNV	ENSG00000147852.16:ENST00000382100.8:exon11:c.C1700T:p.S567F	9p24.2	C3L-02606	8.465e-06	0	0	0	0	1.536e-05	0	0	rs769791140	19.20	D	D	D	D	D	D	M	D	D	0.842	D	D	D	0.721	0.478	0.879	0.536	D	T	D	D	D	D	3.726	25.500	0.998	D	D	0.738	7.682	0.683	7.442	1.000	0.672	0.588	0.702	0.621	.	5.470	5.470	4.915	1.026	0.599	1.000	0.919	0.957	699	.	.	.	.	VLDLR	355	0	697	109	0.135235732009926	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971187	21971187	+	G	G	A	Nonsense_Mutation	SNP	ENST00000304494.9	exon2	c.C172T	p.R58X	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon2:c.C172T:p.R58X	9p21.3	C3L-02606	.	.	.	.	.	.	.	.	rs121913387	4.15	D	T	.	.	N	D	.	T	D	0.185	T	T	.	0.220	.	0.879	.	.	T	T	T	D	T	5.550	34	0.997	N	N	-0.315	1.578	-0.449	1.286	1.000	0.677	0.383	0.608	0.601	.	5.790	2.710	-0.135	1.176	0.676	0.000	0.031	0.057	900	.	.	.	ID=COSV58682666;OCCURENCE=1(salivary_gland),3(breast),9(penis),1(peritoneum),5(liver),18(oesophagus),1(cervix),8(vulva),6(ovary),17(NS),4(haematopoietic_and_lymphoid_tissue),4(stomach),4(urinary_tract),2(soft_tissue),18(pancreas),41(skin),18(lung),42(upper_aerodigestive_tract),1(thymus),1(endometrium)	CDKN2A	341	0	756	130	0.146726862302483	NA	TRUE
ENSG00000165006.14	.	BCM	GRCh38.p13	chr9	34241839	34241839	+	G	G	T	Missense_Mutation	SNP	ENST00000297661.9	exon4	c.G814T	p.D272Y	exonic	ENSG00000165006.14	.	nonsynonymous SNV	ENSG00000165006.14:ENST00000297661.9:exon4:c.G814T:p.D272Y	9p13.3	C3L-02606	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	D	0.888	T	T	D	0.362	0.259	0.452	.	T	T	D	D	D	D	4.106	27.800	0.995	D	D	0.904	11.154	0.920	14.645	1.000	0.707	0.702	0.725	0.714	.	6.170	6.170	7.139	1.176	0.676	1.000	1.000	0.999	294	.	.	.	.	UBAP1	164	0	351	27	0.0714285714285714	TRUE	TRUE
ENSG00000198408.14	.	BCM	GRCh38.p13	chr10	101807869	101807869	+	C	C	A	Missense_Mutation	SNP	ENST00000361464.8	exon5	c.G513T	p.L171F	exonic	ENSG00000198408.14	.	nonsynonymous SNV	ENSG00000198408.14:ENST00000361464.8:exon5:c.G513T:p.L171F	10q24.32	C3L-02606	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	.	T	D	0.765	T	T	D	0.387	0.668	0.642	1.232	D	D	D	D	D	D	3.415	24.400	0.999	D	N	0.765	8.126	0.700	7.748	0.999	0.707	0.725	0.725	0.714	.	5.350	5.350	1.509	0.109	0.549	1.000	1.000	0.999	492	.	.	.	.	OGA	85	1	152	11	0.0674846625766871	TRUE	NA
ENSG00000110321.18	.	BCM	GRCh38.p13	chr11	10805988	10805988	+	G	G	A	Missense_Mutation	SNP	ENST00000526148.5	exon4	c.C167T	p.T56I	exonic	ENSG00000110321.18	.	nonsynonymous SNV	ENSG00000110321.18:ENST00000526148.5:exon4:c.C167T:p.T56I	11p15.4	C3L-02606	.	.	.	.	.	.	.	.	.	5.17	T	T	B	B	D	.	L	T	N	.	T	T	.	0.177	0.243	0.369	.	.	T	T	T	D	D	2.264	21.300	0.956	D	D	-0.061	2.302	0.156	2.977	1.000	0.722	0.672	0.699	0.639	.	5.340	5.340	6.618	1.176	0.676	1.000	1.000	1.000	619	.	.	.	.	EIF4G2	341	0	877	117	0.117706237424547	TRUE	TRUE
ENSG00000175264.8	.	BCM	GRCh38.p13	chr11	45650215	45650215	+	G	G	A	Missense_Mutation	SNP	ENST00000308064.7	exon4	c.C709T	p.R237C	exonic	ENSG00000175264.8	.	nonsynonymous SNV	ENSG00000175264.8:ENST00000308064.7:exon4:c.C709T:p.R237C	11p11.2	C3L-02606	.	.	.	.	.	.	.	.	.	19.19	D	D	D	D	D	D	.	D	D	0.942	D	D	D	0.869	0.948	0.931	2.447	D	D	D	D	D	D	4.417	31	0.999	D	D	0.688	6.961	0.565	5.809	1.000	0.707	0.547	0.604	0.714	.	4.980	4.980	4.359	1.172	0.676	1.000	0.581	0.824	636	Sulfotransferase_domain	.	.	ID=COSV57321999;OCCURENCE=2(large_intestine)	CHST1	110	0	420	39	0.0849673202614379	TRUE	TRUE
ENSG00000172464.3	.	BCM	GRCh38.p13	chr11	56642304	56642304	+	C	C	A	Missense_Mutation	SNP	ENST00000544374.2	exon1	c.G136T	p.V46L	exonic	ENSG00000172464.3	.	nonsynonymous SNV	ENSG00000172464.3:ENST00000544374.2:exon1:c.G136T:p.V46L	11q12.1	C3L-02606	.	.	.	.	.	.	.	.	.	0.16	.	.	B	B	N	N	N	.	.	.	T	T	T	0.078	0.239	0.270	.	T	T	T	T	T	T	0.500	6.501	0.949	N	N	-0.666	0.871	-0.494	1.211	0.000	0.487	0.574	0.574	0.564	.	5.080	4.130	-1.224	0.109	-0.220	0.000	0.921	0.529	445	.	.	.	.	OR5AP2	205	0	374	46	0.10952380952381	TRUE	TRUE
ENSG00000165494.11	.	BCM	GRCh38.p13	chr11	83157558	83157558	+	T	T	A	Missense_Mutation	SNP	ENST00000298281.8	exon1	c.T119A	p.L40Q	exonic	ENSG00000165494.11	.	nonsynonymous SNV	ENSG00000165494.11:ENST00000298281.8:exon1:c.T119A:p.L40Q	11q14.1	C3L-02606	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	N	D	H	T	D	0.969	D	D	D	0.757	0.818	0.978	2.609	D	T	D	D	D	D	4.393	31	0.995	D	D	0.809	8.954	0.735	8.471	1.000	0.733	0.522	0.601	0.562	.	4.840	4.840	7.516	1.138	0.663	1.000	1.000	1.000	407	CID_domain	.	.	.	PCF11	294	0	614	60	0.0890207715133531	TRUE	TRUE
ENSG00000111713.3	.	BCM	GRCh38.p13	chr12	21536998	21536998	+	C	C	T	Missense_Mutation	SNP	ENST00000261195.3	exon16	c.G2068A	p.V690I	exonic	ENSG00000111713.3	.	nonsynonymous SNV	ENSG00000111713.3:ENST00000261195.3:exon16:c.G2068A:p.V690I	12p12.1	C3L-02606	1.648e-05	0	0	0	0	0	0	0.0001	rs148461282	1.20	T	T	B	B	N	N	N	T	N	0.029	T	T	D	0.035	0.152	0.399	0.095	T	T	T	T	T	T	-0.700	0.044	0.750	N	N	-1.382	0.125	-1.358	0.174	0.001	0.554	0.590	0.618	0.530	.	5.460	-2.450	-0.427	-3.396	-0.843	0.000	0.000	0.531	866	.	.	.	.	GYS2	341	0	624	107	0.146374829001368	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-02606	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	267	0	531	78	0.12807881773399	TRUE	TRUE
ENSG00000110925.7	.	BCM	GRCh38.p13	chr12	51067771	51067771	+	G	G	A	Nonsense_Mutation	SNP	ENST00000228515.6	exon4	c.C610T	p.R204X	exonic	ENSG00000110925.7	.	stopgain	ENSG00000110925.7:ENST00000228515.6:exon4:c.C610T:p.R204X	12q13.12	C3L-02606	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.387	.	.	.	.	.	.	.	.	.	D	D	.	.	6.868	36	0.997	D	N	0.575	5.679	0.404	4.390	0.934	0.707	0.725	0.725	0.714	.	4.840	2.910	2.449	-0.235	0.676	0.999	0.991	0.998	183	Cysteine/serine-rich_nuclear_protein,_N-terminal_domain	.	.	.	CSRNP2	225	0	588	39	0.062200956937799	TRUE	TRUE
ENSG00000166226.13	.	BCM	GRCh38.p13	chr12	69587983	69587983	+	G	G	A	Missense_Mutation	SNP	ENST00000299300.11	exon5	c.G310A	p.V104I	exonic	ENSG00000166226.13	.	nonsynonymous SNV	ENSG00000166226.13:ENST00000299300.11:exon5:c.G310A:p.V104I	12q15	C3L-02606	1.649e-05	0	0	0	0	2.998e-05	0	0	rs749401932	9.20	T	T	D	D	D	D	L	T	N	0.502	T	D	D	0.405	0.573	0.657	0.452	T	T	T	T	D	T	3.484	24.700	0.997	D	D	0.729	7.550	0.752	8.842	1.000	0.707	0.725	0.702	0.714	.	5.660	5.660	7.776	1.161	0.676	1.000	0.998	0.994	872	.	.	.	ID=COSV54739289;OCCURENCE=2(large_intestine),1(stomach)	CCT2	212	0	363	26	0.0668380462724936	TRUE	TRUE
ENSG00000133101.10	.	BCM	GRCh38.p13	chr13	36438693	36438693	+	C	C	T	Missense_Mutation	SNP	ENST00000255465.7	exon5	c.C719T	p.T240M	exonic	ENSG00000133101.10	.	nonsynonymous SNV	ENSG00000133101.10:ENST00000255465.7:exon5:c.C719T:p.T240M	13q13.3	C3L-02606	2.474e-05	0	0.0002	0	0	1.499e-05	0	0	rs750419153	14.20	D	D	D	D	D	D	H	T	D	0.862	T	T	D	0.520	0.576	0.859	1.245	T	T	T	D	D	D	3.095	23.600	0.999	D	D	0.945	12.263	0.858	12.062	1.000	0.706	0.476	0.618	0.613	.	5.330	5.330	7.685	1.026	0.599	1.000	0.709	0.299	905	Cyclin,_N-terminal	.	.	ID=COSV55222625;OCCURENCE=1(endometrium)	CCNA1	248	0	631	77	0.108757062146893	TRUE	TRUE
ENSG00000088387.19	.	BCM	GRCh38.p13	chr13	98867521	98867521	+	T	T	A	Nonsense_Mutation	SNP	ENST00000652315.1	exon30	c.A3193T	p.K1065X	exonic	ENSG00000088387.19	.	stopgain	ENSG00000088387.19:ENST00000652315.1:exon30:c.A3193T:p.K1065X	13q32.3	C3L-02606	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.568	.	.	.	.	.	.	.	.	.	D	D	.	.	8.923	46	0.997	D	N	0.961	12.726	0.866	12.355	1.000	0.672	0.588	0.659	0.711	.	6.080	6.080	7.602	1.138	0.665	1.000	1.000	0.998	946	.	.	.	.	DOCK9	127	0	174	24	0.121212121212121	TRUE	TRUE
ENSG00000139880.19	.	BCM	GRCh38.p13	chr14	23054268	23054268	+	C	C	T	Missense_Mutation	SNP	ENST00000397359.7	exon6	c.G845A	p.R282Q	exonic	ENSG00000139880.19	.	nonsynonymous SNV	ENSG00000139880.19:ENST00000397359.7:exon6:c.G845A:p.R282Q	14q11.2	C3L-02606	3.354e-05	0	0	0	0	1.525e-05	0	0.0002	rs764282796	1.20	T	T	B	B	N	N	N	T	N	0.226	T	T	T	0.060	0.509	0.545	0.421	T	T	T	T	T	D	1.735	17.270	0.998	N	N	-0.528	1.122	-0.406	1.361	1.000	0.707	0.611	0.723	0.714	.	4.770	3.790	0.342	0.138	0.599	0.000	0.978	0.987	809	Cadherin-like	.	.	ID=COSV52974166;OCCURENCE=1(stomach)	CDH24	94	0	160	18	0.101123595505618	TRUE	TRUE
ENSG00000165379.13	.	BCM	GRCh38.p13	chr14	41887124	41887124	+	G	G	T	Missense_Mutation	SNP	ENST00000298119.8	exon3	c.G499T	p.V167F	exonic	ENSG00000165379.13	.	nonsynonymous SNV	ENSG00000165379.13:ENST00000298119.8:exon3:c.G499T:p.V167F	14q21.1	C3L-02606	.	.	.	.	.	.	.	.	.	12.20	T	D	B	B	D	D	N	T	D	0.729	T	T	D	0.541	0.625	0.713	1.365	T	D	D	D	D	D	3.210	23.900	0.979	D	D	-0.279	1.667	0.046	2.522	0.474	0.554	0.574	0.618	0.564	.	5.560	5.560	7.779	1.176	0.676	1.000	0.999	0.996	921	.	.	.	ID=COSV53242887;OCCURENCE=1(lung)	LRFN5	160	0	367	29	0.0732323232323232	TRUE	TRUE
ENSG00000140459.18	.	BCM	GRCh38.p13	chr15	74345115	74345115	+	C	C	T	Missense_Mutation	SNP	ENST00000268053.11	exon3	c.G554A	p.R185H	exonic	ENSG00000140459.18	.	nonsynonymous SNV	ENSG00000140459.18:ENST00000268053.11:exon3:c.G554A:p.R185H	15q24.1	C3L-02606	1.648e-05	0	0	0.0001	0	0	0	6.057e-05	rs763099365	9.20	D	T	P	B	D	D	M	T	D	0.227	T	T	D	0.305	0.609	0.911	0.524	T	T	T	T	D	D	3.188	23.800	0.998	D	N	0.116	2.949	0.128	2.852	1.000	0.616	0.588	0.616	0.527	.	4.370	4.370	1.718	1.016	0.577	1.000	0.974	0.206	814	.	.	.	ID=COSV51430559;OCCURENCE=1(liver),1(large_intestine),1(lung),1(endometrium)	CYP11A1	167	1	299	32	0.0966767371601208	TRUE	TRUE
ENSG00000103313.12	.	BCM	GRCh38.p13	chr16	3249750	3249750	+	C	C	T	Missense_Mutation	SNP	ENST00000219596.5	exon3	c.G941A	p.R314H	exonic	ENSG00000103313.12	.	nonsynonymous SNV	ENSG00000103313.12:ENST00000219596.5:exon3:c.G941A:p.R314H	16p13.3	C3L-02606	0.0001	0	0	0	0	9.296e-05	0	0.0006	rs104895204	0.20	T	T	B	B	N	N	N	T	N	0.080	T	T	T	0.060	.	0.454	0.144	T	T	T	T	T	T	-0.525	0.105	0.657	N	N	-1.754	0.029	-1.752	0.041	1.000	0.487	0.574	0.547	0.542	.	3.900	-1.030	-0.910	-1.001	-1.716	0.000	0.001	0.000	794	.	.	.	ID=COSV54825955;OCCURENCE=1(oesophagus),1(large_intestine),1(endometrium)	MEFV	127	1	314	29	0.0845481049562682	TRUE	TRUE
ENSG00000167207.13	.	BCM	GRCh38.p13	chr16	50710842	50710842	+	C	C	T	Missense_Mutation	SNP	ENST00000300589.6	exon4	c.C931T	p.R311W	exonic	ENSG00000167207.13	.	nonsynonymous SNV	ENSG00000167207.13:ENST00000300589.6:exon4:c.C931T:p.R311W	16q12.1	C3L-02606	0.0005	0.0002	0.0006	0.0017	0	0.0005	0.0011	6.064e-05	rs104895427	11.20	D	D	D	D	N	D	M	T	D	0.337	T	D	D	0.627	.	0.937	0.498	T	T	T	T	T	T	3.719	25.500	0.999	D	D	0.533	5.306	0.537	5.518	1.000	0.707	0.725	0.547	0.564	.	5.620	5.620	2.880	-0.268	-0.189	1.000	0.082	0.785	701	NACHT_nucleoside_triphosphatase	.	.	ID=COSV56049177;OCCURENCE=1(oesophagus),1(soft_tissue),1(prostate)	NOD2	505	0	1194	126	0.0954545454545455	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674220	7674220	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.G743A	p.R248Q	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.G743A:p.R248Q	17p13.1	C3L-02606	5.768e-05	0	0	0.0002	0	7.493e-05	0	0	rs11540652	19.20	D	D	D	D	D	A	M	D	D	0.946	D	D	D	0.934	.	0.975	0.412	T	D	D	D	D	D	4.282	29.400	0.999	D	D	0.660	6.591	0.561	5.765	0.799	0.722	0.702	0.725	0.735	.	4.620	3.650	6.163	1.021	0.596	1.000	0.981	0.841	433	p53,_DNA-binding_domain	.	.	ID=COSV52661580;OCCURENCE=3(salivary_gland),148(breast),3(penis),1(peritoneum),13(liver),1(genital_tract),73(oesophagus),2(adrenal_gland),1(meninges),4(cervix),277(large_intestine),71(central_nervous_system),10(biliary_tract),3(pleura),11(vulva),57(ovary),8(bone),8(NS),70(stomach),116(haematopoietic_and_lymphoid_tissue),6(soft_tissue),8(kidney),57(urinary_tract),34(pancreas),1(pituitary),23(skin),46(prostate),53(lung),18(thyroid),74(upper_aerodigestive_tract),1(testis),1(eye),1(thymus),11(small_intestine),44(endometrium)	TP53	275	1	575	104	0.153166421207658	TRUE	TRUE
ENSG00000175832.13	.	BCM	GRCh38.p13	chr17	43545343	43545343	+	G	G	A	Missense_Mutation	SNP	ENST00000319349.10	exon3	c.C85T	p.R29C	exonic	ENSG00000175832.13	.	nonsynonymous SNV	ENSG00000175832.13:ENST00000319349.10:exon3:c.C85T:p.R29C	17q21.31	C3L-02606	.	.	.	.	.	.	.	.	.	4.20	D	T	B	B	N	D	N	T	N	0.384	T	T	T	0.080	0.533	0.460	0.848	T	T	T	T	D	T	2.991	23.400	0.991	D	N	-0.301	1.611	-0.133	1.955	1.000	0.652	0.749	0.522	0.562	.	5.150	2.870	0.965	0.168	0.675	0.997	0.999	0.999	489	PEA3-type_ETS-domain_transcription_factor,_N-terminal	.	.	.	ETV4	82	0	159	25	0.135869565217391	TRUE	TRUE
ENSG00000172421.9	.	BCM	GRCh38.p13	chr17	62407180	62407180	+	T	T	C	Missense_Mutation	SNP	ENST00000305286.7	exon8	c.T835C	p.Y279H	exonic	ENSG00000172421.9	.	nonsynonymous SNV	ENSG00000172421.9:ENST00000305286.7:exon8:c.T835C:p.Y279H	17q23.2	C3L-02606	.	.	.	.	.	.	.	.	.	7.20	T	D	D	D	N	D	M	T	N	0.652	T	T	T	0.275	0.458	0.793	0.567	T	T	T	T	D	T	3.009	23.400	0.991	D	N	0.452	4.685	0.425	4.543	0.023	0.487	0.574	0.547	0.542	.	5.910	5.910	2.616	1.138	0.609	1.000	0.990	0.830	715	.	.	.	.	EFCAB3	60	0	79	20	0.202020202020202	TRUE	TRUE
ENSG00000159640.16	.	BCM	GRCh38.p13	chr17	63477197	63477197	+	C	C	A	Missense_Mutation	SNP	ENST00000290866.10	exon1	c.C103A	p.Q35K	exonic	ENSG00000159640.16	.	nonsynonymous SNV	ENSG00000159640.16:ENST00000290866.10:exon1:c.C103A:p.Q35K	17q23.3	C3L-02606	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	M	T	N	0.206	T	T	D	0.090	0.522	0.498	0.116	T	T	T	T	T	T	1.095	12.730	0.662	N	N	-0.621	0.950	-0.605	1.039	1.000	0.652	0.492	0.607	0.710	.	4.320	2.110	0.396	0.839	0.485	0.086	0.791	0.729	940	.	.	.	.	ACE	174	0	351	53	0.131188118811881	TRUE	TRUE
ENSG00000154263.17	.	BCM	GRCh38.p13	chr17	69222599	69222599	+	A	A	-	Frame_Shift_Del	DEL	ENST00000269081.8	exon5	c.133delT	p.S45Hfs*4	exonic	ENSG00000154263.17	.	frameshift deletion	ENSG00000154263.17:ENST00000269081.8:exon5:c.133delT:p.S45Hfs*4	17q24.3	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABCA10	136	0	120	11	0.083969465648855	TRUE	TRUE
ENSG00000152217.19	.	BCM	GRCh38.p13	chr18	44953301	44953301	+	C	C	T	Missense_Mutation	SNP	ENST00000649279.2	exon4	c.C3961T	p.R1321C	exonic	ENSG00000152217.19	.	nonsynonymous SNV	ENSG00000152217.19:ENST00000649279.2:exon4:c.C3961T:p.R1321C	18q12.3	C3L-02606	2.508e-05	0	0	0	0	4.562e-05	0	0	rs767301100	13.20	D	D	D	D	D	D	L	T	D	0.657	T	T	D	0.389	.	0.521	1.009	T	T	D	D	D	D	4.051	27.400	0.999	D	N	0.606	5.980	0.650	6.911	0.961	0.707	0.725	0.659	0.564	.	6.170	6.170	3.495	1.026	0.599	1.000	1.000	0.998	860	.	.	.	.	SETBP1	312	0	592	48	0.075	TRUE	NA
ENSG00000197647.11	.	BCM	GRCh38.p13	chr19	12016403	12016403	+	G	G	A	Missense_Mutation	SNP	ENST00000344980.10	exon4	c.C464T	p.S155F	exonic	ENSG00000197647.11	.	nonsynonymous SNV	ENSG00000197647.11:ENST00000344980.10:exon4:c.C464T:p.S155F	19p13.2	C3L-02606	.	.	.	.	.	.	.	.	.	4.19	D	D	P	B	.	N	M	T	D	0.225	T	T	T	0.090	0.594	0.226	0.111	T	T	T	T	T	T	0.710	8.547	0.965	N	N	-0.856	0.577	-1.102	0.373	0.072	0.563	0.654	0.537	0.492	.	1.140	-2.270	-0.310	-0.984	-0.392	0.000	0.000	0.001	934	Zinc_finger_C2H2-type	.	.	.	ZNF433	270	0	316	57	0.152815013404826	TRUE	NA
ENSG00000128016.7	.	BCM	GRCh38.p13	chr19	39407824	39407824	+	G	G	A	Missense_Mutation	SNP	ENST00000597629.3	exon2	c.G106A	p.G36R	exonic	ENSG00000128016.7	.	nonsynonymous SNV	ENSG00000128016.7:ENST00000597629.3:exon2:c.G106A:p.G36R	19q13.2	C3L-02606	.	.	.	.	.	.	.	.	.	0.14	.	T	.	.	U	N	.	T	.	0.106	T	T	T	0.048	.	0.043	0.509	T	.	T	T	T	T	1.740	17.300	0.996	N	N	-0.709	0.797	-0.673	0.939	1.000	0.726	0.522	0.594	0.639	.	3.680	1.360	0.682	1.176	0.606	0.000	0.728	0.535	687	.	.	.	.	ZFP36	61	0	273	32	0.104918032786885	TRUE	TRUE
ENSG00000086544.3	.	BCM	GRCh38.p13	chr19	40717750	40717750	+	G	G	C	Missense_Mutation	SNP	ENST00000263370.3	exon1	c.G615C	p.Q205H	exonic	ENSG00000086544.3	.	nonsynonymous SNV	ENSG00000086544.3:ENST00000263370.3:exon1:c.G615C:p.Q205H	19q13.2	C3L-02606	.	.	.	.	.	.	.	.	.	1.19	D	T	B	B	N	N	L	.	N	0.089	T	T	T	0.094	0.146	0.225	0.516	T	T	T	T	T	T	1.567	16.160	0.810	N	N	-0.812	0.637	-0.837	0.707	1.000	0.405	0.517	0.522	0.562	.	4.030	0.355	0.476	0.245	0.618	0.000	0.929	0.969	536	.	.	.	.	ITPKC	186	0	645	37	0.0542521994134897	TRUE	TRUE
ENSG00000177398.18	.	BCM	GRCh38.p13	chr21	42127688	42127688	+	A	A	-	Frame_Shift_Del	DEL	ENST00000408910.6	exon20	c.3547delA	p.T1183Hfs*5	exonic	ENSG00000177398.18	.	frameshift deletion	ENSG00000177398.18:ENST00000408910.6:exon20:c.3547delA:p.T1183Hfs*5	21q22.3	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UMODL1	153	1	273	52	0.16	TRUE	TRUE
ENSG00000090776.6	.	BCM	GRCh38.p13	chrX	68840262	68840262	+	A	A	T	Nonsense_Mutation	SNP	ENST00000204961.5	exon5	c.A649T	p.K217X	exonic	ENSG00000090776.6	.	stopgain	ENSG00000090776.6:ENST00000204961.5:exon5:c.A649T:p.K217X	Xq13.1	C3L-02606	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	N	D	.	.	.	0.750	.	.	.	.	.	.	.	.	.	D	D	.	.	6.778	36	0.994	D	.	.	.	.	.	1.000	.	.	.	.	.	5.160	5.160	2.148	1.312	0.756	0.998	1.000	0.998	595	.	.	.	.	EFNB1	304	0	640	113	0.150066401062417	TRUE	TRUE
ENSG00000162062.15	.	BCM	GRCh38.p13	chr16	2460814	2460814	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000162062.15	ENST00000361837.9:exon4:c.197-2A>G	.	.	16p13.3	C3L-02606	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	3.317	24.200	0.970	D	.	0.696	7.060	0.441	4.665	1.000	0.256	0.177	0.218	0.288	0.954	4.590	4.590	1.415	0.315	0.756	0.085	0.035	0.396	713	.	.	.	.	TEDC2	80	0	192	31	0.139013452914798	TRUE	TRUE
ENSG00000211452.11	.	BCM	GRCh38.p13	chr1	53894505	53894505	+	C	C	T	Unknown	SNP	NA	NA	NA	NA	exonic	ENSG00000211452.11	.	unknown	UNKNOWN	1p32.3	C3L-02606	0.0002	0	0.0002	0	0	0.0002	0	0	rs144654417	1.8	.	.	.	.	.	D	.	.	.	0.181	.	.	T	.	.	0.040	.	.	.	T	T	T	T	1.144	13.170	0.949	N	N	-1.103	0.304	-1.230	0.259	1.000	0.554	0.588	0.573	0.613	.	4.660	-8.310	-1.044	0.138	0.599	0.000	0.820	0.761	819	.	.	.	ID=COSV50778811;OCCURENCE=1(stomach),1(lung)	DIO1	204	0	460	45	0.0891089108910891	TRUE	NA
ENSG00000178752.16	.	BCM	GRCh38.p13	chr2	238161602	238161602	+	C	C	T	Silent	SNP	ENST00000546354.6	exon2	c.C207T	p.T69T	exonic	ENSG00000178752.16	.	synonymous SNV	ENSG00000178752.16:ENST00000546354.6:exon2:c.C207T:p.T69T	2q37.3	C3L-02606	.	.	.	.	.	.	.	.	rs970950289	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60137478;OCCURENCE=1(breast)	ERFE	36	0	111	29	0.207142857142857	TRUE	NA
ENSG00000144596.13	.	BCM	GRCh38.p13	chr3	14517827	14517827	+	G	G	A	Silent	SNP	ENST00000621039.5	exon10	c.C1101T	p.P367P	exonic	ENSG00000144596.13	.	synonymous SNV	ENSG00000144596.13:ENST00000621039.5:exon10:c.C1101T:p.P367P	3p25.1	C3L-02606	.	.	.	.	.	.	.	.	rs892714157	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GRIP2	112	0	259	40	0.133779264214047	TRUE	NA
ENSG00000163848.19	.	BCM	GRCh38.p13	chr3	125232683	125232683	+	A	A	G	Silent	SNP	ENST00000360647.8	exon9	c.T2043C	p.G681G	exonic	ENSG00000163848.19	.	synonymous SNV	ENSG00000163848.19:ENST00000360647.8:exon9:c.T2043C:p.G681G	3q21.2	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF148	205	1	460	55	0.106796116504854	TRUE	TRUE
ENSG00000172752.14	.	BCM	GRCh38.p13	chr3	130385168	130385168	+	C	C	T	Silent	SNP	ENST00000265379.10	exon5	c.C1665T	p.S555S	exonic	ENSG00000172752.14	.	synonymous SNV	ENSG00000172752.14:ENST00000265379.10:exon5:c.C1665T:p.S555S	3q22.1	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL6A5	295	0	643	46	0.0667634252539913	TRUE	TRUE
ENSG00000026652.15	.	BCM	GRCh38.p13	chr6	161146569	161146569	+	G	G	A	Silent	SNP	ENST00000320285.9	exon7	c.C798T	p.D266D	exonic	ENSG00000026652.15	.	synonymous SNV	ENSG00000026652.15:ENST00000320285.9:exon7:c.C798T:p.D266D	6q26	C3L-02606	0.0061	0.0626	0.0033	0.0041	0	0.0002	0.0033	0.0002	rs16892215	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100212079;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	AGPAT4	168	0	358	35	0.089058524173028	TRUE	NA
ENSG00000034677.13	.	BCM	GRCh38.p13	chr8	100259997	100259997	+	C	C	T	Silent	SNP	ENST00000341084.7	exon9	c.G1683A	p.R561R	exonic	ENSG00000034677.13	.	synonymous SNV	ENSG00000034677.13:ENST00000341084.7:exon9:c.G1683A:p.R561R	8q22.2	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF19A	189	1	395	48	0.108352144469526	TRUE	TRUE
ENSG00000171435.14	.	BCM	GRCh38.p13	chr12	117539822	117539822	+	C	C	T	Silent	SNP	ENST00000339824.7	exon10	c.G1584A	p.T528T	exonic	ENSG00000171435.14	.	synonymous SNV	ENSG00000171435.14:ENST00000339824.7:exon10:c.G1584A:p.T528T	12q24.22	C3L-02606	4.16e-05	0	0	0.0006	0	0	0	0	rs753143776	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56676969;OCCURENCE=1(pancreas),1(upper_aerodigestive_tract),1(endometrium)	KSR2	195	0	389	43	0.099537037037037	TRUE	TRUE
ENSG00000136099.13	.	BCM	GRCh38.p13	chr13	52847948	52847948	+	G	G	A	Silent	SNP	ENST00000377942.7	exon1	c.C489T	p.D163D	exonic	ENSG00000136099.13	.	synonymous SNV	ENSG00000136099.13:ENST00000377942.7:exon1:c.C489T:p.D163D	13q14.3	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58810931;OCCURENCE=1(stomach)	PCDH8	100	0	386	52	0.118721461187215	TRUE	TRUE
ENSG00000188869.13	.	BCM	GRCh38.p13	chr15	81372686	81372686	+	C	C	T	Silent	SNP	ENST00000359440.6	exon2	c.G141A	p.P47P	exonic	ENSG00000188869.13	.	synonymous SNV	ENSG00000188869.13:ENST00000359440.6:exon2:c.G141A:p.P47P	15q25.1	C3L-02606	0.0001	0	0	0	0	4.499e-05	0	0.0007	rs375088581	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63925040;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	TMC3	181	0	424	27	0.0598669623059867	TRUE	NA
ENSG00000081138.14	.	BCM	GRCh38.p13	chr18	65814510	65814510	+	G	G	A	Silent	SNP	ENST00000397968.4	exon4	c.G531A	p.A177A	exonic	ENSG00000081138.14	.	synonymous SNV	ENSG00000081138.14:ENST00000397968.4:exon4:c.G531A:p.A177A	18q22.1	C3L-02606	2.471e-05	9.61e-05	8.64e-05	0	0	1.498e-05	0	0	rs567500655	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59881966;OCCURENCE=1(large_intestine)	CDH7	291	0	551	60	0.0981996726677578	TRUE	TRUE
ENSG00000160179.18	.	BCM	GRCh38.p13	chr21	42290193	42290193	+	G	G	A	Silent	SNP	ENST00000361802.6	exon11	c.G1404A	p.A468A	exonic	ENSG00000160179.18	.	synonymous SNV	ENSG00000160179.18:ENST00000361802.6:exon11:c.G1404A:p.A468A	21q22.3	C3L-02606	8.241e-06	0	0	0.0001	0	0	0	0	rs61735842	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABCG1	138	0	370	54	0.127358490566038	TRUE	NA
ENSG00000100346.18	.	BCM	GRCh38.p13	chr22	39681037	39681037	+	C	C	T	Silent	SNP	ENST00000402142.4	exon34	c.C5649T	p.G1883G	exonic	ENSG00000100346.18	.	synonymous SNV	ENSG00000100346.18:ENST00000402142.4:exon34:c.C5649T:p.G1883G	22q13.1	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA1I	76	0	260	38	0.12751677852349	TRUE	TRUE
ENSG00000165288.11	.	BCM	GRCh38.p13	chrX	80734181	80734181	+	C	C	G	Silent	SNP	ENST00000373275.5	exon11	c.G1023C	p.V341V	exonic	ENSG00000165288.11	.	synonymous SNV	ENSG00000165288.11:ENST00000373275.5:exon11:c.G1023C:p.V341V	Xq21.1	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BRWD3	231	1	342	26	0.0706521739130435	TRUE	TRUE
ENSG00000127603.29	.	BCM	GRCh38.p13	chr1	39411780	39411780	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000127603.29	.	.	.	1p34.3	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57130946;OCCURENCE=1(large_intestine)	MACF1	192	0	392	33	0.0776470588235294	TRUE	NA
ENSG00000203664.7	.	BCM	GRCh38.p13	chr1	247491412	247491412	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000203664.7	.	.	.	1q44	C3L-02606	0.0011	0.0002	8.637e-05	0	0	4.497e-05	0	0.0079	rs201479742	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR2W5	249	0	635	53	0.0770348837209302	TRUE	NA
ENSG00000115457.10	.	BCM	GRCh38.p13	chr2	216661795	216661795	+	T	T	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000115457.10	.	.	.	2q35	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGFBP2	224	0	648	40	0.0581395348837209	NA	TRUE
ENSG00000144560.15	.	BCM	GRCh38.p13	chr3	11671394	11671394	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000144560.15;ENSG00000144559.10	dist=27479;dist=135900	.	.	3p25.2	C3L-02606	5.68e-05	0.0001	0	0	0	5.214e-05	0	0.0001	rs751713418	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VGLL4	74	0	161	29	0.152631578947368	TRUE	NA
ENSG00000136444.10	.	BCM	GRCh38.p13	chr17	50480118	50480118	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000136444.10	.	.	.	17q21.33	C3L-02606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RSAD1	155	0	362	70	0.162037037037037	TRUE	NA
ENSG00000167614.14	.	BCM	GRCh38.p13	chr19	54416871	54416871	+	C	C	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000167614.14	.	.	.	19q13.42	C3L-02606	.	.	.	.	.	.	.	.	.	1.14	D	.	.	.	.	N	.	T	N	.	T	T	T	0.006	0.273	0.043	.	.	T	T	T	T	T	0.099	2.079	0.778	N	N	-0.985	0.420	-1.074	0.402	0.992	0.598	0.590	0.607	0.639	.	2.680	1.470	-0.931	0.073	0.589	0.000	0.002	0.002	982	.	.	.	.	TTYH1	121	0	483	161	0.25	TRUE	TRUE
ENSG00000116793.16	.	BCM	GRCh38.p13	chr1	113724853	113724853	+	T	T	A	Missense_Mutation	SNP	ENST00000369604.6	exon7	c.A529T	p.N177Y	exonic	ENSG00000116793.16	.	nonsynonymous SNV	ENSG00000116793.16:ENST00000369604.6:exon7:c.A529T:p.N177Y	1p13.2	C3N-03061	.	.	.	.	.	.	.	.	.	7.19	D	D	B	B	N	D	L	.	D	0.552	T	T	T	0.148	0.125	0.227	0.312	T	T	T	T	D	D	2.369	21.900	0.985	D	N	-0.355	1.484	-0.183	1.826	0.004	0.732	0.709	0.651	0.728	.	5.140	2.580	1.549	1.138	0.665	1.000	1.000	0.997	675	.	.	.	.	PHTF1	108	0	155	15	0.0882352941176471	TRUE	TRUE
ENSG00000007908.16	.	BCM	GRCh38.p13	chr1	169728082	169728082	+	C	C	T	Missense_Mutation	SNP	ENST00000333360.12	exon8	c.G1255A	p.D419N	exonic	ENSG00000007908.16	.	nonsynonymous SNV	ENSG00000007908.16:ENST00000333360.12:exon8:c.G1255A:p.D419N	1q24.2	C3N-03061	.	.	.	.	.	.	.	.	.	6.20	T	T	D	D	D	D	L	T	N	0.210	T	T	T	0.208	0.475	0.830	0.069	T	T	T	T	D	T	2.332	21.800	0.998	D	N	0.333	3.957	0.349	4.015	1.000	0.625	0.590	0.574	0.595	.	5.250	5.250	0.430	1.026	0.599	0.119	0.904	0.774	545	Sushi/SCR/CCP_domain	.	.	.	SELE	143	0	141	29	0.170588235294118	TRUE	NA
ENSG00000000971.16	.	BCM	GRCh38.p13	chr1	196676002	196676002	+	G	G	A	Missense_Mutation	SNP	ENST00000367429.9	exon4	c.G364A	p.G122S	exonic	ENSG00000000971.16	.	nonsynonymous SNV	ENSG00000000971.16:ENST00000367429.9:exon4:c.G364A:p.G122S	1q31.3	C3N-03061	.	.	.	.	.	.	.	.	.	4.18	T	T	P	P	.	N	.	T	D	0.358	T	T	D	0.281	0.837	0.902	0.386	T	T	T	T	D	T	3.065	23.600	0.997	N	D	0.001	2.516	-0.046	2.208	0.001	0.706	0.574	0.574	0.613	.	5.500	2.120	2.490	1.175	0.676	0.982	0.357	0.944	545	Sushi/SCR/CCP_domain	.	.	.	CFH	99	0	123	38	0.236024844720497	TRUE	TRUE
ENSG00000117724.13	.	BCM	GRCh38.p13	chr1	214618655	214618655	+	A	A	T	Missense_Mutation	SNP	ENST00000366955.8	exon4	c.A442T	p.I148F	exonic	ENSG00000117724.13	.	nonsynonymous SNV	ENSG00000117724.13:ENST00000366955.8:exon4:c.A442T:p.I148F	1q41	C3N-03061	.	.	.	.	.	.	.	.	rs936369720	2.19	T	T	D	P	N	N	.	T	N	0.235	T	T	T	0.099	.	0.375	0.189	T	T	T	T	T	T	1.630	16.560	0.948	D	N	-0.102	2.169	-0.242	1.688	0.789	0.722	0.725	0.725	0.735	.	5.420	-1.680	2.215	-0.113	0.691	0.899	0.972	0.961	884	.	.	.	ID=COSV65276969;OCCURENCE=1(large_intestine)	CENPF	170	0	170	24	0.123711340206186	TRUE	TRUE
ENSG00000116141.16	.	BCM	GRCh38.p13	chr1	220599860	220599860	+	G	G	C	Missense_Mutation	SNP	ENST00000366917.6	exon5	c.G421C	p.G141R	exonic	ENSG00000116141.16	.	nonsynonymous SNV	ENSG00000116141.16:ENST00000366917.6:exon5:c.G421C:p.G141R	1q41	C3N-03061	.	.	.	.	.	.	.	.	.	15.20	D	T	D	D	D	D	M	T	D	0.819	T	T	D	0.453	0.781	0.589	2.171	D	T	D	D	D	D	3.536	24.800	0.999	D	D	0.886	10.701	0.856	12.010	1.000	0.615	0.574	0.659	0.568	.	5.340	5.340	9.116	1.155	0.676	1.000	0.998	0.996	855	Protein_kinase_domain	.	.	.	MARK1	41	0	57	17	0.22972972972973	TRUE	TRUE
ENSG00000143751.10	.	BCM	GRCh38.p13	chr1	225999303	225999303	+	C	C	G	Missense_Mutation	SNP	ENST00000272091.8	exon1	c.G10C	p.A4P	exonic	ENSG00000143751.10	.	nonsynonymous SNV	ENSG00000143751.10:ENST00000272091.8:exon1:c.G10C:p.A4P	1q42.12	C3N-03061	.	.	.	.	.	.	.	.	rs897210734	2.20	D	T	B	B	N	N	M	T	N	0.205	T	T	T	0.122	.	0.115	0.233	T	T	T	T	T	T	-0.608	0.070	0.901	N	N	-1.389	0.122	-1.583	0.080	1.000	0.442	0.522	0.520	0.373	.	4.950	-9.900	-4.042	0.094	0.599	0.000	0.008	0.001	764	.	.	.	.	SDE2	150	0	151	27	0.151685393258427	TRUE	NA
ENSG00000144406.19	.	BCM	GRCh38.p13	chr2	209839392	209839392	+	G	G	A	Missense_Mutation	SNP	ENST00000439458.5	exon19	c.G3212A	p.R1071H	exonic	ENSG00000144406.19	.	nonsynonymous SNV	ENSG00000144406.19:ENST00000439458.5:exon19:c.G3212A:p.R1071H	2q34	C3N-03061	4.452e-05	0	0	0	0	0	0	0.0001	rs755460416	9.20	D	D	B	B	D	D	N	T	N	0.499	T	T	T	0.155	0.272	0.254	1.181	D	T	T	T	D	D	3.045	23.500	1.000	D	D	0.192	3.268	0.379	4.210	0.995	0.595	0.574	0.598	0.564	.	5.880	5.880	8.190	1.176	0.676	1.000	0.997	0.677	814	.	.	.	ID=COSV55888864;OCCURENCE=1(large_intestine),1(stomach),1(pancreas)	UNC80	312	0	324	41	0.112328767123288	TRUE	TRUE
ENSG00000168301.13	.	BCM	GRCh38.p13	chr3	58501321	58501321	+	C	C	T	Missense_Mutation	SNP	ENST00000404589.8	exon3	c.C403T	p.P135S	exonic	ENSG00000168301.13	.	nonsynonymous SNV	ENSG00000168301.13:ENST00000404589.8:exon3:c.C403T:p.P135S	3p14.3	C3N-03061	.	.	.	.	.	.	.	.	.	9.19	D	T	P	B	D	D	N	T	N	0.658	T	T	D	0.235	0.445	0.778	1.209	D	T	D	T	D	D	2.364	21.900	0.993	D	.	0.292	3.740	0.445	4.692	1.000	0.706	0.654	0.710	0.636	.	5.660	5.660	7.905	1.026	0.549	1.000	1.000	0.995	628	.	.	.	.	KCTD6	105	0	82	18	0.18	TRUE	TRUE
ENSG00000121892.15	.	BCM	GRCh38.p13	chr4	39904094	39904097	+	CTGA	CTGA	-	Frame_Shift_Del	DEL	ENST00000303538.13	exon12	c.1328_1331del	p.V443Afs*3	exonic	ENSG00000121892.15	.	frameshift deletion	ENSG00000121892.15:ENST00000303538.13:exon12:c.1328_1331del:p.V443Afs*3	4p14	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDS5A	152	0	182	30	0.141509433962264	TRUE	NA
ENSG00000138640.15	.	BCM	GRCh38.p13	chr4	88851038	88851038	+	C	C	T	Missense_Mutation	SNP	ENST00000264344.10	exon7	c.G989A	p.S330N	exonic	ENSG00000138640.15	.	nonsynonymous SNV	ENSG00000138640.15:ENST00000264344.10:exon7:c.G989A:p.S330N	4q22.1	C3N-03061	8.241e-06	0	0	0	0	1.5e-05	0	0	rs753411487	1.20	D	T	B	B	N	N	N	T	N	0.026	T	T	T	0.067	0.245	0.285	0.172	T	T	T	T	T	T	0.386	5.267	0.756	N	N	-1.012	0.392	-1.054	0.425	0.123	0.638	0.574	0.653	0.568	.	4.330	0.130	-0.170	0.096	0.599	0.000	0.007	0.191	833	.	.	.	.	FAM13A	127	0	126	32	0.20253164556962	TRUE	NA
ENSG00000218336.9	.	BCM	GRCh38.p13	chr4	182754482	182754482	+	G	G	A	Missense_Mutation	SNP	ENST00000511685.6	exon22	c.G4115A	p.R1372H	exonic	ENSG00000218336.9	.	nonsynonymous SNV	ENSG00000218336.9:ENST00000511685.6:exon22:c.G4115A:p.R1372H	4q35.1	C3N-03061	0.0002	0.0001	0.0001	0	0.0002	1.706e-05	0	0.0012	rs543878787	5.19	T	T	B	B	.	D	N	D	N	0.158	T	T	T	0.305	0.551	0.082	0.344	T	T	T	T	T	D	2.206	20.900	0.970	D	D	-0.127	2.090	0.103	2.749	1.000	0.706	0.574	0.725	0.613	.	5.580	5.580	5.008	1.083	0.676	1.000	0.978	0.986	955	.	.	.	ID=COSV69304543;OCCURENCE=2(large_intestine),2(biliary_tract),1(upper_aerodigestive_tract),1(endometrium)	TENM3	206	0	164	44	0.211538461538462	TRUE	TRUE
ENSG00000142319.18	.	BCM	GRCh38.p13	chr5	1403049	1403049	+	-	NA	G	Frame_Shift_Ins	NA	ENST00000270349.12	exon13	c.1639dupC	p.H547Pfs*56	exonic	ENSG00000142319.18	.	frameshift insertion	ENSG00000142319.18:ENST00000270349.12:exon13:c.1639dupC:p.H547Pfs*56	5p15.33	C3N-03061	5.078e-05	0	8.812e-05	0	0	7.701e-05	0	0	rs749320240	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC6A3	NA	NA	NA	NA	NA	NA	NA
ENSG00000164236.12	.	BCM	GRCh38.p13	chr5	10649784	10649784	+	G	G	A	Missense_Mutation	SNP	ENST00000296657.7	exon4	c.G1156A	p.G386S	exonic	ENSG00000164236.12	.	nonsynonymous SNV	ENSG00000164236.12:ENST00000296657.7:exon4:c.G1156A:p.G386S	5p15.2	C3N-03061	.	.	.	.	.	.	.	.	.	1.18	T	T	.	.	N	N	N	T	N	0.025	T	T	D	0.013	0.188	0.030	.	T	T	T	T	T	T	-0.674	0.050	0.839	N	N	-1.073	0.331	-1.137	0.339	1.000	0.672	0.702	0.576	0.613	.	4.840	-0.535	0.233	-2.606	-1.140	0.002	0.000	0.000	981	.	.	.	.	ANKRD33B	73	0	97	20	0.170940170940171	TRUE	TRUE
ENSG00000262576.3	.	BCM	GRCh38.p13	chr5	141356656	141356656	+	C	C	T	Nonsense_Mutation	SNP	ENST00000571252.3	exon1	c.C1549T	p.R517X	exonic	ENSG00000262576.3	.	stopgain	ENSG00000262576.3:ENST00000571252.3:exon1:c.C1549T:p.R517X	5q31.3	C3N-03061	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	A	.	.	.	0.093	.	.	.	.	.	.	.	.	.	D	D	.	.	4.822	33	0.985	N	N	.	.	.	.	0.720	0.625	0.547	0.602	0.595	.	5.570	3.640	-1.304	-0.319	-0.223	0.000	0.009	0.041	641	Cadherin-like	.	.	ID=COSV53897391;OCCURENCE=1(large_intestine),2(stomach),1(skin),1(lung)	PCDHGA4	160	0	196	41	0.172995780590717	TRUE	TRUE
ENSG00000086570.12	.	BCM	GRCh38.p13	chr5	151553248	151553248	+	T	T	A	Missense_Mutation	SNP	ENST00000261800.5	exon5	c.A4085T	p.D1362V	exonic	ENSG00000086570.12	.	nonsynonymous SNV	ENSG00000086570.12:ENST00000261800.5:exon5:c.A4085T:p.D1362V	5q33.1	C3N-03061	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	D	0.897	T	T	D	0.558	0.504	0.864	0.677	T	T	D	D	D	D	4.144	28.100	0.995	D	D	0.643	6.397	0.646	6.856	1.000	0.554	0.574	0.618	0.564	.	5.380	5.380	7.610	1.138	0.665	1.000	0.932	0.921	886	Cadherin-like	.	.	.	FAT2	384	0	379	57	0.130733944954128	TRUE	TRUE
ENSG00000137338.5	.	BCM	GRCh38.p13	chr6	28284009	28284009	+	C	C	T	Nonsense_Mutation	SNP	ENST00000259883.3	exon2	c.C196T	p.R66X	exonic	ENSG00000137338.5	.	stopgain	ENSG00000137338.5:ENST00000259883.3:exon2:c.C196T:p.R66X	6p22.1	C3N-03061	0.0005	9.617e-05	0.0003	0	0	0.0008	0	0	rs141311101	3.5	.	.	.	.	.	A	.	.	.	0.032	.	.	.	.	.	.	.	.	.	D	D	.	.	5.149	33	0.998	N	N	0.276	3.659	0.013	2.406	0.980	0.707	0.654	0.702	0.714	.	4.560	3.690	-0.014	0.877	0.599	0.000	0.985	0.910	513	SCAN_domain	.	.	.	PGBD1	139	0	135	34	0.201183431952663	TRUE	NA
ENSG00000137411.18	.	BCM	GRCh38.p13	chr6	30916898	30916900	+	AGC	AGC	-	In_Frame_Del	DEL	ENST00000321897.9	exon7	c.692_694del	p.Q232del	exonic	ENSG00000137411.18	.	nonframeshift deletion	ENSG00000137411.18:ENST00000321897.9:exon7:c.692_694del:p.Q232del	6p21.33	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VARS2	278	0	282	35	0.110410094637224	TRUE	TRUE
ENSG00000124678.20	.	BCM	GRCh38.p13	chr6	35122303	35122303	+	C	C	T	Missense_Mutation	SNP	ENST00000311875.11	exon5	c.G392A	p.R131H	exonic	ENSG00000124678.20	.	nonsynonymous SNV	ENSG00000124678.20:ENST00000311875.11:exon5:c.G392A:p.R131H	6p21.31	C3N-03061	1.648e-05	9.612e-05	0	0	0	1.499e-05	0	0	rs150752841	13.20	D	D	D	D	D	D	M	T	D	0.628	T	T	D	0.321	.	0.692	0.396	T	T	T	T	D	D	3.756	25.600	0.999	D	D	0.723	7.459	0.625	6.557	0.857	0.554	0.588	0.574	0.542	.	4.330	4.330	4.703	1.026	0.599	1.000	0.843	0.902	377	.	.	.	ID=COSV99774226;OCCURENCE=1(endometrium)	TCP11	196	0	249	24	0.0879120879120879	TRUE	NA
ENSG00000196569.12	.	BCM	GRCh38.p13	chr6	129481332	129481332	+	A	A	G	Missense_Mutation	SNP	ENST00000421865.2	exon55	c.A7642G	p.T2548A	exonic	ENSG00000196569.12	.	nonsynonymous SNV	ENSG00000196569.12:ENST00000421865.2:exon55:c.A7642G:p.T2548A	6q22.33	C3N-03061	.	.	.	.	.	.	.	.	.	13.19	T	.	D	D	D	D	M	T	N	0.776	D	D	D	0.528	0.376	0.918	0.294	T	T	D	D	D	T	3.336	24.200	0.993	D	D	0.631	6.256	0.620	6.485	0.997	0.638	0.610	0.653	0.509	.	5.110	5.110	6.630	1.312	0.756	1.000	1.000	0.986	769	Laminin_G_domain	.	.	.	LAMA2	341	0	326	67	0.170483460559796	TRUE	TRUE
ENSG00000157927.17	.	BCM	GRCh38.p13	chr7	4799422	4799422	+	C	C	T	Missense_Mutation	SNP	ENST00000399583.4	exon15	c.G3184A	p.V1062M	exonic	ENSG00000157927.17	.	nonsynonymous SNV	ENSG00000157927.17:ENST00000399583.4:exon15:c.G3184A:p.V1062M	7p22.1	C3N-03061	3.328e-05	0	0.0002	0.0001	0	0	0	6.057e-05	rs747213896	0.20	T	T	B	B	N	N	N	T	N	0.127	T	T	T	0.030	.	0.237	0.044	T	T	T	T	T	T	0.692	8.377	0.848	N	N	-0.952	0.458	-0.978	0.517	0.020	0.646	0.514	0.645	0.605	.	4.930	-1.460	0.366	0.138	0.549	0.001	0.242	0.165	825	.	.	.	ID=COSV68201980;OCCURENCE=1(lung)	RADIL	261	0	245	38	0.134275618374558	TRUE	TRUE
ENSG00000218823.2	.	BCM	GRCh38.p13	chr7	4861453	4861453	+	C	C	T	Missense_Mutation	SNP	ENST00000404991.2	exon1	c.G358A	p.V120I	exonic	ENSG00000218823.2	.	nonsynonymous SNV	ENSG00000218823.2:ENST00000404991.2:exon1:c.G358A:p.V120I	7p22.1	C3N-03061	.	.	.	.	.	.	.	.	.	7.14	.	D	D	P	.	D	.	.	.	0.121	T	T	T	0.180	.	0.725	0.305	T	.	T	T	D	D	3.044	23.500	0.990	D	D	0.084	2.822	-0.040	2.227	1.000	0.542	0.460	0.547	0.568	.	3.980	2.180	6.093	0.127	-0.266	1.000	0.966	0.836	840	Poly(A)_polymerase,_central_domain;Polymerase,_nucleotidyl_transferase_domain	.	.	ID=COSV68200319;OCCURENCE=1(liver),2(pancreas)	PAPOLB	117	0	184	16	0.08	TRUE	TRUE
ENSG00000136297.14	.	BCM	GRCh38.p13	chr7	4907566	4907566	+	C	C	T	Missense_Mutation	SNP	ENST00000404774.7	exon7	c.G643A	p.G215R	exonic	ENSG00000136297.14	.	nonsynonymous SNV	ENSG00000136297.14:ENST00000404774.7:exon7:c.G643A:p.G215R	7p22.1	C3N-03061	2.49e-05	0	0	0	0	3.005e-05	0	6.059e-05	rs375097927	15.20	D	D	D	D	D	D	H	T	D	0.976	T	T	D	0.735	.	0.723	0.287	T	T	D	D	D	D	4.094	27.700	0.999	D	D	0.949	12.390	0.860	12.153	1.000	0.487	0.574	0.573	0.613	.	5.600	5.600	7.789	1.019	0.593	1.000	0.718	0.885	835	.	.	.	ID=COSV68661071;OCCURENCE=1(pancreas)	MMD2	337	1	367	53	0.126190476190476	TRUE	TRUE
ENSG00000179869.15	.	BCM	GRCh38.p13	chr7	48520218	48520218	+	G	G	A	Missense_Mutation	SNP	ENST00000435803.6	exon53	c.G13975A	p.V4659M	exonic	ENSG00000179869.15	.	nonsynonymous SNV	ENSG00000179869.15:ENST00000435803.6:exon53:c.G13975A:p.V4659M	7p12.3	C3N-03061	5.847e-05	0.0002	8.767e-05	0	0	4.523e-05	0	6.127e-05	rs369296047	4.16	T	D	.	.	N	N	.	D	N	0.474	T	D	D	0.296	.	0.605	0.185	T	.	T	T	T	T	1.143	13.170	0.993	N	N	-0.217	1.829	-0.357	1.451	0.000	0.487	0.574	0.574	0.564	.	5.140	1.690	0.702	-0.536	-0.108	0.527	0.029	0.276	811	.	.	.	ID=COSV68947920;OCCURENCE=1(large_intestine),1(stomach)	ABCA13	143	0	139	24	0.147239263803681	TRUE	TRUE
ENSG00000221900.6	.	BCM	GRCh38.p13	chr7	53036048	53036048	+	G	G	A	Missense_Mutation	SNP	ENST00000408890.6	exon1	c.G377A	p.R126H	exonic	ENSG00000221900.6	.	nonsynonymous SNV	ENSG00000221900.6:ENST00000408890.6:exon1:c.G377A:p.R126H	7p12.1	C3N-03061	.	.	.	.	.	.	.	.	.	2.19	T	T	D	P	.	N	N	T	N	0.089	T	T	T	0.080	0.396	0.055	0.386	T	T	T	T	D	T	1.212	13.730	0.998	N	N	-0.534	1.110	-0.724	0.865	0.000	0.487	0.574	0.547	0.564	.	2.690	1.780	-0.044	-0.357	-0.938	0.000	0.000	0.000	981	.	.	.	ID=COSV68692958;OCCURENCE=3(large_intestine),1(central_nervous_system)	POM121L12	360	0	342	47	0.120822622107969	TRUE	TRUE
ENSG00000185274.12	.	BCM	GRCh38.p13	chr7	71132866	71132866	+	G	G	A	Missense_Mutation	SNP	ENST00000333538.10	exon1	c.G64A	p.V22M	exonic	ENSG00000185274.12	.	nonsynonymous SNV	ENSG00000185274.12:ENST00000333538.10:exon1:c.G64A:p.V22M	7q11.22	C3N-03061	.	.	.	.	.	.	.	.	.	6.19	T	T	P	B	N	D	.	T	N	0.190	T	T	T	0.131	0.396	0.496	0.618	D	T	T	T	D	D	2.884	23.200	0.996	D	D	0.148	3.082	0.292	3.672	1.000	0.487	0.574	0.522	0.563	.	4.850	4.850	5.963	1.172	0.672	1.000	1.000	0.971	938	.	.	.	ID=COSV61194968;OCCURENCE=1(large_intestine)	GALNT17	342	0	329	43	0.115591397849462	TRUE	TRUE
ENSG00000106236.4	.	BCM	GRCh38.p13	chr7	98619697	98619697	+	G	G	T	Missense_Mutation	SNP	ENST00000265634.4	exon2	c.G481T	p.V161L	exonic	ENSG00000106236.4	.	nonsynonymous SNV	ENSG00000106236.4:ENST00000265634.4:exon2:c.G481T:p.V161L	7q22.1	C3N-03061	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	N	T	N	0.217	T	T	T	0.067	0.200	0.236	0.345	T	T	T	T	T	T	1.743	17.320	0.886	D	D	-0.676	0.853	-0.503	1.196	1.000	0.789	0.596	0.768	0.639	.	4.510	1.000	2.081	0.224	0.618	1.000	0.987	0.806	228	.	.	.	.	NPTX2	410	1	423	54	0.113207547169811	TRUE	TRUE
ENSG00000104447.12	.	BCM	GRCh38.p13	chr8	115587578	115587578	+	C	C	T	Missense_Mutation	SNP	ENST00000640765.1	exon4	c.G2084A	p.R695H	exonic	ENSG00000104447.12	.	nonsynonymous SNV	ENSG00000104447.12:ENST00000640765.1:exon4:c.G2084A:p.R695H	8q23.3	C3N-03061	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	N	0.790	T	T	T	0.339	0.476	0.283	1.680	T	T	T	T	D	D	4.155	28.200	0.999	D	D	0.734	7.618	0.765	9.163	1.000	0.638	0.588	0.659	0.668	.	5.770	5.770	6.236	1.026	0.599	1.000	1.000	0.997	942	Zinc_finger_C2H2-type	.	.	ID=COSV55234192;OCCURENCE=1(upper_aerodigestive_tract)	TRPS1	245	0	179	52	0.225108225108225	TRUE	TRUE
ENSG00000183354.12	.	BCM	GRCh38.p13	chr9	5929093	5929093	+	C	C	G	Missense_Mutation	SNP	ENST00000399933.8	exon6	c.G2449C	p.E817Q	exonic	ENSG00000183354.12	.	nonsynonymous SNV	ENSG00000183354.12:ENST00000399933.8:exon6:c.G2449C:p.E817Q	9p24.1	C3N-03061	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	D	D	N	.	N	0.697	T	T	T	0.217	0.183	0.470	.	D	T	T	T	D	D	3.780	25.700	0.998	D	D	0.715	7.336	0.746	8.715	1.000	0.651	0.709	0.659	0.646	.	5.510	5.510	7.253	1.026	0.599	1.000	1.000	0.998	352	.	.	.	.	KIAA2026	66	0	91	12	0.116504854368932	TRUE	TRUE
ENSG00000198825.15	.	BCM	GRCh38.p13	chr10	119807987	119807987	+	G	G	A	Missense_Mutation	SNP	ENST00000650623.2	exon13	c.G1496A	p.R499H	exonic	ENSG00000198825.15	.	nonsynonymous SNV	ENSG00000198825.15:ENST00000650623.2:exon13:c.G1496A:p.R499H	10q26.11	C3N-03061	8.247e-06	0	0	0	0	1.501e-05	0	0	rs775019768	9.20	D	T	D	P	D	D	L	T	N	0.625	T	T	T	0.325	.	0.519	0.652	T	T	D	T	D	D	4.394	31	0.999	D	D	0.753	7.925	0.788	9.787	1.000	0.722	0.699	0.710	0.688	.	5.550	5.550	9.878	1.176	0.618	1.000	0.975	0.975	545	SAC_domain	.	.	ID=COSV62820038;OCCURENCE=3(oesophagus),3(large_intestine),1(stomach),1(endometrium)	INPP5F	143	0	118	12	0.0923076923076923	NA	TRUE
ENSG00000060749.15	.	BCM	GRCh38.p13	chr11	32932367	32932367	+	C	C	T	Missense_Mutation	SNP	ENST00000399302.7	exon4	c.C722T	p.S241F	exonic	ENSG00000060749.15	.	nonsynonymous SNV	ENSG00000060749.15:ENST00000399302.7:exon4:c.C722T:p.S241F	11p13	C3N-03061	.	.	.	.	.	.	.	.	.	5.20	D	T	P	B	N	D	L	T	N	0.148	T	T	T	0.045	0.239	0.103	0.266	T	T	T	T	D	D	2.887	23.200	0.997	D	N	0.290	3.726	0.357	4.068	0.374	0.707	0.546	0.725	0.714	.	4.980	4.050	3.134	1.026	0.599	1.000	0.998	0.996	492	.	.	.	.	QSER1	193	0	217	18	0.0765957446808511	TRUE	TRUE
ENSG00000181903.5	.	BCM	GRCh38.p13	chr11	55665729	55665729	+	C	C	T	Missense_Mutation	SNP	ENST00000641251.1	exon1	c.C563T	p.T188M	exonic	ENSG00000181903.5	.	nonsynonymous SNV	ENSG00000181903.5:ENST00000641251.1:exon1:c.C563T:p.T188M	11q11	C3N-03061	0.0001	0.0002	0.0002	0.0003	0.0002	7.494e-05	0	0.0003	rs372457190	1.20	T	T	B	B	N	N	M	T	N	0.047	T	T	T	0.010	.	0.166	0.002	T	T	T	T	T	T	-0.526	0.105	0.326	N	N	-1.163	0.254	-1.219	0.267	0.000	0.487	0.574	0.574	0.564	.	4.070	-2.790	-1.770	-0.591	-0.244	0.000	0.002	0.079	145	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58602389;OCCURENCE=2(pancreas)	OR4C6	205	0	223	24	0.097165991902834	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-03061	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	253	0	306	51	0.142857142857143	TRUE	TRUE
ENSG00000167548.15	.	BCM	GRCh38.p13	chr12	49052696	49052696	+	C	C	A	Nonsense_Mutation	SNP	ENST00000301067.11	exon9	c.G1126T	p.E376X	exonic	ENSG00000167548.15	.	stopgain	ENSG00000167548.15:ENST00000301067.11:exon9:c.G1126T:p.E376X	12q13.12	C3N-03061	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.696	.	.	.	.	.	.	.	.	.	D	D	.	.	6.710	36	0.995	D	N	1.006	14.120	0.851	11.805	1.000	0.707	0.725	0.702	0.714	.	5.340	5.340	2.686	1.026	0.549	0.998	0.999	0.988	360	.	.	.	.	KMT2D	98	0	115	25	0.178571428571429	TRUE	TRUE
ENSG00000075035.10	.	BCM	GRCh38.p13	chr12	108210186	108210186	+	C	C	T	Missense_Mutation	SNP	ENST00000547525.6	exon4	c.C563T	p.T188M	exonic	ENSG00000075035.10	.	nonsynonymous SNV	ENSG00000075035.10:ENST00000547525.6:exon4:c.C563T:p.T188M	12q23.3	C3N-03061	1.696e-05	0	0	0	0	3.074e-05	0	0	rs749318050	2.20	T	T	B	B	N	N	L	T	N	0.352	T	T	D	0.119	.	0.278	0.463	T	T	T	T	D	T	1.897	18.460	0.988	N	N	-0.150	2.022	-0.110	2.019	1.000	0.554	0.590	0.602	0.613	.	5.120	5.120	2.856	1.016	0.587	0.021	0.060	0.892	889	Carbohydrate-binding_WSC	.	.	ID=COSV54586324;OCCURENCE=1(breast)	WSCD2	562	2	517	98	0.159349593495935	TRUE	TRUE
ENSG00000123191.16	.	BCM	GRCh38.p13	chr13	51934759	51934759	+	G	G	C	Missense_Mutation	SNP	ENST00000242839.10	exon21	c.C4395G	p.I1465M	exonic	ENSG00000123191.16	.	nonsynonymous SNV	ENSG00000123191.16:ENST00000242839.10:exon21:c.C4395G:p.I1465M	13q14.3	C3N-03061	.	.	.	.	.	.	.	.	.	12.20	D	D	B	B	N	D	L	D	N	0.326	D	D	D	0.500	0.243	0.754	0.101	T	D	D	D	D	T	2.101	20.100	0.986	D	N	-0.198	1.882	-0.090	2.075	1.000	0.615	0.611	0.650	0.655	.	5.350	4.490	1.763	1.176	0.676	1.000	0.894	0.705	491	.	.	.	.	ATP7B	523	0	593	76	0.113602391629297	TRUE	TRUE
ENSG00000123191.16	.	BCM	GRCh38.p13	chr13	51935623	51935623	+	G	G	A	Missense_Mutation	SNP	ENST00000242839.10	exon20	c.C4094T	p.S1365F	exonic	ENSG00000123191.16	.	nonsynonymous SNV	ENSG00000123191.16:ENST00000242839.10:exon20:c.C4094T:p.S1365F	13q14.3	C3N-03061	9.365e-06	0	0	0	0	1.654e-05	0	0	rs747301758	19.20	D	D	D	D	D	D	M	D	D	0.949	D	D	D	0.911	0.552	0.977	0.390	T	D	D	D	D	D	4.395	31	0.998	D	D	0.813	9.049	0.810	10.414	1.000	0.615	0.563	0.616	0.646	.	5.230	5.230	9.460	1.083	0.676	1.000	0.999	0.994	485	.	.	.	.	ATP7B	265	0	284	42	0.128834355828221	TRUE	NA
ENSG00000068650.18	.	BCM	GRCh38.p13	chr13	112831541	112831541	+	A	A	C	Missense_Mutation	SNP	ENST00000487903.5	exon13	c.A1388C	p.N463T	exonic	ENSG00000068650.18	.	nonsynonymous SNV	ENSG00000068650.18:ENST00000487903.5:exon13:c.A1388C:p.N463T	13q34	C3N-03061	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	D	N	0.287	T	T	T	0.139	0.333	0.451	0.301	T	T	T	T	T	T	1.293	14.340	0.631	D	N	-0.355	1.484	-0.294	1.577	1.000	0.707	0.702	0.702	0.714	.	5.450	4.570	2.873	0.182	-0.156	0.961	0.006	0.415	994	.	.	.	.	ATP11A	91	0	95	37	0.28030303030303	TRUE	TRUE
ENSG00000139874.6	.	BCM	GRCh38.p13	chr14	38210174	38210174	+	G	G	A	Missense_Mutation	SNP	ENST00000267377.3	exon3	c.G785A	p.R262H	exonic	ENSG00000139874.6	.	nonsynonymous SNV	ENSG00000139874.6:ENST00000267377.3:exon3:c.G785A:p.R262H	14q21.1	C3N-03061	.	.	.	.	.	.	.	.	.	15.20	D	D	D	P	D	D	M	T	D	0.576	T	T	D	0.339	0.501	0.593	2.029	D	D	D	T	D	D	4.619	32	1.000	D	D	0.795	8.687	0.776	9.449	1.000	0.658	0.574	0.619	0.619	.	4.820	4.820	9.968	1.155	0.676	1.000	1.000	1.000	804	GPCR,_rhodopsin-like,_7TM	.	.	.	SSTR1	201	0	134	30	0.182926829268293	TRUE	TRUE
ENSG00000198133.8	.	BCM	GRCh38.p13	chr14	67473728	67473728	+	G	G	A	Missense_Mutation	SNP	ENST00000357461.6	exon3	c.C196T	p.R66W	exonic	ENSG00000198133.8	.	nonsynonymous SNV	ENSG00000198133.8:ENST00000357461.6:exon3:c.C196T:p.R66W	14q24.1	C3N-03061	.	.	.	.	.	.	.	.	rs926386994	4.19	T	T	P	B	N	N	N	.	N	0.304	T	T	T	0.063	0.404	0.105	1.237	T	T	T	T	D	D	3.160	23.800	0.998	D	D	0.219	3.390	0.304	3.742	0.863	0.534	0.588	0.686	0.542	.	4.690	4.690	4.247	1.176	0.676	1.000	0.998	0.992	298	.	.	.	.	TMEM229B	289	0	302	59	0.163434903047091	TRUE	NA
ENSG00000139985.7	.	BCM	GRCh38.p13	chr14	70457897	70457897	+	G	G	A	Missense_Mutation	SNP	ENST00000603540.2	exon2	c.G398A	p.R133Q	exonic	ENSG00000139985.7	.	nonsynonymous SNV	ENSG00000139985.7:ENST00000603540.2:exon2:c.G398A:p.R133Q	14q24.2	C3N-03061	.	.	.	.	.	.	.	.	.	0.18	.	T	B	B	N	N	N	T	.	0.086	T	T	T	0.116	0.805	0.118	0.486	T	T	T	T	T	T	0.116	2.243	0.685	N	N	-1.350	0.139	-1.400	0.151	0.017	0.516	0.610	0.547	0.613	.	3.760	-1.670	0.299	0.215	-0.221	0.000	0.028	0.086	741	Peptidase_M12B,_propeptide	.	.	ID=COSV50804868;OCCURENCE=1(large_intestine),1(lung)	ADAM21	167	0	167	36	0.177339901477833	NA	TRUE
ENSG00000241839.10	.	BCM	GRCh38.p13	chr15	64855006	64855006	+	G	G	A	Missense_Mutation	SNP	ENST00000323544.5	exon3	c.G248A	p.R83H	exonic	ENSG00000241839.10;ENSG00000249240.2	.	nonsynonymous SNV	ENSG00000241839.10:ENST00000323544.5:exon3:c.G248A:p.R83H,ENSG00000249240.2:ENST00000437723.1:exon3:c.G248A:p.R83H	15q22.31	C3N-03061	8.719e-05	0.0002	0	0	0	0.0001	0	0	rs144415889	8.20	T	T	D	D	D	D	L	T	N	0.395	T	T	D	0.436	.	0.706	0.560	T	T	T	T	T	D	4.373	31	0.999	D	D	0.614	6.069	0.627	6.575	1.000	0.707	0.702	0.725	0.714	.	5.190	5.190	4.931	1.176	0.676	0.998	0.999	0.986	195	Pleckstrin_homology_domain	.	.	ID=COSV60261731;OCCURENCE=1(endometrium)	PLEKHO2	247	0	293	42	0.125373134328358	TRUE	TRUE
ENSG00000156218.13	.	BCM	GRCh38.p13	chr15	84016491	84016491	+	C	C	T	Missense_Mutation	SNP	ENST00000286744.10	exon25	c.C4265T	p.P1422L	exonic	ENSG00000156218.13	.	nonsynonymous SNV	ENSG00000156218.13:ENST00000286744.10:exon25:c.C4265T:p.P1422L	15q25.2	C3N-03061	3.382e-05	0	0	0.0002	0	3.081e-05	0	0	rs199806479	0.20	T	T	B	B	N	N	N	T	N	0.124	T	T	T	0.039	0.393	0.436	0.126	T	T	T	T	T	T	0.297	4.258	0.085	N	N	-1.374	0.128	-1.328	0.191	0.000	0.581	0.588	0.565	0.564	.	4.530	0.791	0.368	0.204	-0.114	0.000	0.044	0.346	635	.	.	.	ID=COSV54470395;OCCURENCE=2(skin)	ADAMTSL3	125	0	124	20	0.138888888888889	TRUE	TRUE
ENSG00000166813.15	.	BCM	GRCh38.p13	chr15	89648280	89648280	+	G	G	A	Missense_Mutation	SNP	ENST00000394412.8	exon5	c.C1418T	p.A473V	exonic	ENSG00000166813.15	.	nonsynonymous SNV	ENSG00000166813.15:ENST00000394412.8:exon5:c.C1418T:p.A473V	15q26.1	C3N-03061	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	U	N	L	T	N	0.026	T	T	D	0.075	0.101	0.175	0.019	T	T	T	T	T	T	1.566	16.160	0.993	N	N	-1.044	0.359	-1.086	0.390	0.999	0.696	0.547	0.692	0.605	.	4.090	1.060	1.363	0.215	-0.132	0.004	0.052	0.010	843	.	.	.	.	KIF7	200	0	210	29	0.121338912133891	TRUE	NA
ENSG00000185905.4	.	BCM	GRCh38.p13	chr16	29744306	29744306	+	G	G	A	Missense_Mutation	SNP	ENST00000329410.4	exon2	c.C646T	p.R216C	exonic	ENSG00000185905.4	.	nonsynonymous SNV	ENSG00000185905.4:ENST00000329410.4:exon2:c.C646T:p.R216C	16p11.2	C3N-03061	9.211e-06	0	0	0	0	1.664e-05	0	0	rs775079638	11.19	D	D	D	D	U	D	L	T	D	0.662	T	T	D	0.454	0.340	0.679	1.344	.	T	D	D	D	T	3.522	24.800	0.999	D	N	0.307	3.818	0.286	3.637	1.000	0.742	0.586	0.775	0.542	.	5.800	3.610	0.387	0.138	0.604	0.123	0.818	0.864	476	.	.	.	ID=COSV61477192;OCCURENCE=3(large_intestine)	C16orf54	503	0	600	114	0.159663865546218	TRUE	TRUE
ENSG00000171724.3	.	BCM	GRCh38.p13	chr16	77884669	77884669	+	G	G	T	Missense_Mutation	SNP	ENST00000302536.3	exon7	c.G944T	p.G315V	exonic	ENSG00000171724.3	.	nonsynonymous SNV	ENSG00000171724.3:ENST00000302536.3:exon7:c.G944T:p.G315V	16q23.1	C3N-03061	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.948	T	T	D	0.677	0.857	0.454	0.599	D	T	D	D	D	D	3.961	26.700	0.998	D	D	0.832	9.432	0.760	9.053	1.000	0.635	0.610	0.644	0.568	.	5.920	5.920	9.602	1.176	0.676	1.000	0.199	0.777	948	Polyketide_synthase,_enoylreductase_domain	.	.	.	VAT1L	236	1	256	45	0.149501661129568	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7676082	7676082	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000269305.8	exon4	c.286dupT	p.S96Ffs*53	exonic	ENSG00000141510.17	.	frameshift insertion	ENSG00000141510.17:ENST00000269305.8:exon4:c.286dupT:p.S96Ffs*53	17p13.1	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	NA	NA	NA	NA	NA	NA	NA
ENSG00000132481.7	.	BCM	GRCh38.p13	chr17	75877987	75877987	+	G	G	A	Missense_Mutation	SNP	ENST00000254816.6	exon1	c.C562T	p.P188S	exonic	ENSG00000132481.7	.	nonsynonymous SNV	ENSG00000132481.7:ENST00000254816.6:exon1:c.C562T:p.P188S	17q25.1	C3N-03061	0	0	0	0	0	0	0	0	rs534004186	8.20	T	D	B	B	D	D	M	T	N	0.089	T	T	D	0.062	0.379	0.556	2.728	D	T	T	T	D	T	2.243	21.200	0.998	D	N	-0.176	1.946	-0.101	2.045	1.000	0.443	0.552	0.666	0.242	.	4.300	4.300	1.382	1.076	0.573	0.003	0.998	0.997	883	B-box-type_zinc_finger	.	.	.	TRIM47	212	0	233	37	0.137037037037037	TRUE	NA
ENSG00000180777.14	.	BCM	GRCh38.p13	chr18	14837289	14837289	+	A	A	T	Missense_Mutation	SNP	ENST00000358984.9	exon29	c.A2569T	p.N857Y	exonic	ENSG00000180777.14	.	nonsynonymous SNV	ENSG00000180777.14:ENST00000358984.9:exon29:c.A2569T:p.N857Y	18p11.21	C3N-03061	.	.	.	.	.	.	.	.	.	2.17	D	D	.	.	.	N	L	T	N	0.268	T	T	T	0.075	0.122	0.185	0.086	T	T	T	T	T	T	1.785	17.620	0.973	N	N	-0.656	0.888	-0.895	0.626	0.000	0.487	0.574	0.547	0.564	.	1.820	-0.852	-0.205	-0.008	0.487	0.001	0.246	0.042	923	.	.	.	.	ANKRD30B	84	0	159	34	0.176165803108808	NA	TRUE
ENSG00000183287.14	.	BCM	GRCh38.p13	chr18	59439811	59439811	+	G	G	C	Missense_Mutation	SNP	ENST00000439986.9	exon8	c.C781G	p.P261A	exonic	ENSG00000183287.14	.	nonsynonymous SNV	ENSG00000183287.14:ENST00000439986.9:exon8:c.C781G:p.P261A	18q21.32	C3N-03061	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.266	T	T	D	0.343	0.257	0.861	0.200	T	T	T	T	D	T	2.620	22.700	0.984	D	D	0.172	3.183	0.261	3.495	1.000	0.615	0.588	0.659	0.564	.	4.220	4.220	6.191	1.172	0.671	1.000	0.993	0.991	964	.	.	.	.	CCBE1	185	0	154	36	0.189473684210526	TRUE	TRUE
ENSG00000119559.17	.	BCM	GRCh38.p13	chr19	1475220	1475220	+	C	C	A	Missense_Mutation	SNP	ENST00000585675.6	exon3	c.G169T	p.A57S	exonic	ENSG00000119559.17	.	nonsynonymous SNV	ENSG00000119559.17:ENST00000585675.6:exon3:c.G169T:p.A57S	19p13.3	C3N-03061	.	.	.	.	.	.	.	.	.	1.18	T	D	P	B	N	N	L	.	N	0.134	T	T	T	0.047	0.114	0.170	0.150	.	T	T	T	T	T	0.378	5.185	0.987	N	N	-0.548	1.084	-0.666	0.950	0.999	0.713	0.644	0.636	0.711	.	3.980	2.900	1.039	-0.305	-0.201	0.002	0.029	0.009	964	.	.	.	.	C19orf25	170	0	152	29	0.160220994475138	TRUE	TRUE
ENSG00000187650.4	.	BCM	GRCh38.p13	chr19	5909096	5909096	+	C	C	T	Missense_Mutation	SNP	ENST00000339485.4	exon2	c.C464T	p.A155V	exonic	ENSG00000187650.4	.	nonsynonymous SNV	ENSG00000187650.4:ENST00000339485.4:exon2:c.C464T:p.A155V	19p13.3	C3N-03061	9.064e-05	0	0	0	0	0	0	0.0002	rs751669540	0.19	T	T	B	B	N	N	N	.	N	0.018	T	T	T	0.030	0.017	0.014	0.482	T	T	T	T	T	T	-0.635	0.061	0.830	N	N	-1.476	0.089	-1.588	0.079	1.000	0.615	0.634	0.659	0.714	.	4.530	-7.370	-1.195	-1.107	-0.881	0.000	0.000	0.003	878	.	.	.	ID=COSV100258937;OCCURENCE=1(endometrium)	VMAC	283	0	242	56	0.187919463087248	TRUE	NA
ENSG00000187664.9	.	BCM	GRCh38.p13	chr19	19257908	19257908	+	G	G	T	Missense_Mutation	SNP	ENST00000291481.8	exon5	c.C1118A	p.A373E	exonic	ENSG00000187664.9	.	nonsynonymous SNV	ENSG00000187664.9:ENST00000291481.8:exon5:c.C1118A:p.A373E	19p13.11	C3N-03061	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	N	N	N	T	N	0.308	T	T	D	0.077	0.329	0.570	0.809	D	T	T	T	T	T	2.458	22.300	0.925	N	N	-0.507	1.162	-0.536	1.144	0.004	0.581	0.547	0.576	0.563	.	4.350	3.250	1.396	1.061	0.649	0.883	0.015	0.091	814	.	.	.	.	HAPLN4	188	1	206	31	0.130801687763713	TRUE	NA
ENSG00000196109.9	.	BCM	GRCh38.p13	chr19	22180533	22180533	+	C	C	A	Missense_Mutation	SNP	ENST00000397121.3	exon3	c.G1184T	p.C395F	exonic	ENSG00000196109.9	.	nonsynonymous SNV	ENSG00000196109.9:ENST00000397121.3:exon3:c.G1184T:p.C395F	19p12	C3N-03061	.	.	.	.	.	.	.	.	.	10.19	D	D	D	D	.	N	H	D	D	0.177	T	D	T	0.199	0.922	0.884	0.208	T	T	T	T	D	D	2.424	22.200	0.965	N	N	-0.007	2.486	-0.345	1.474	0.000	0.487	0.574	0.574	0.564	.	0.810	-0.534	3.662	0.455	0.203	0.958	0.131	0.003	988	Zinc_finger_C2H2-type	.	.	.	ZNF676	353	1	395	48	0.108352144469526	NA	TRUE
ENSG00000186020.13	.	BCM	GRCh38.p13	chr19	36546927	36546927	+	C	C	A	Missense_Mutation	SNP	ENST00000591340.6	exon5	c.G1631T	p.S544I	exonic	ENSG00000186020.13	.	nonsynonymous SNV	ENSG00000186020.13:ENST00000591340.6:exon5:c.G1631T:p.S544I	19q13.12	C3N-03061	.	.	.	.	.	.	.	.	.	0.15	.	T	.	.	.	N	L	T	.	0.152	T	T	T	0.038	.	0.216	0.299	T	T	T	T	T	T	0.076	1.884	0.599	N	N	-0.763	0.710	-0.936	0.572	0.456	0.707	0.725	0.609	0.646	.	2.550	1.510	-1.516	-0.021	-0.372	0.000	0.405	0.013	428	Zinc_finger_C2H2-type	.	.	.	ZNF529	129	1	139	25	0.152439024390244	TRUE	TRUE
ENSG00000197863.9	.	BCM	GRCh38.p13	chr19	36823297	36823297	+	C	C	T	Missense_Mutation	SNP	ENST00000356725.9	exon4	c.G217A	p.G73R	exonic	ENSG00000197863.9	.	nonsynonymous SNV	ENSG00000197863.9:ENST00000356725.9:exon4:c.G217A:p.G73R	19q13.12	C3N-03061	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	L	T	N	0.190	T	T	T	0.018	0.275	0.193	0.058	T	T	T	T	T	T	-0.047	1.068	0.820	N	N	-1.691	0.038	-1.751	0.042	0.000	0.563	0.588	0.576	0.636	.	3.630	-4.410	-0.230	-1.286	-1.208	0.000	0.000	0.573	584	Krueppel-associated_box	.	.	.	ZNF790	134	0	176	28	0.137254901960784	TRUE	TRUE
ENSG00000179954.16	.	BCM	GRCh38.p13	chr19	55517478	55517478	+	G	G	A	Missense_Mutation	SNP	ENST00000389623.11	exon14	c.G3202A	p.D1068N	exonic	ENSG00000179954.16	.	nonsynonymous SNV	ENSG00000179954.16:ENST00000389623.11:exon14:c.G3202A:p.D1068N	19q13.42	C3N-03061	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	.	N	N	T	N	0.048	T	T	D	0.054	0.182	0.030	0.015	T	T	T	T	T	T	0.778	9.177	0.969	N	N	-1.152	0.263	-1.191	0.291	1.000	0.000	0.166	0.585	0.375	.	2.990	0.613	1.167	0.014	-0.293	0.004	0.005	0.112	958	.	.	.	.	SSC5D	455	1	501	74	0.128695652173913	TRUE	TRUE
ENSG00000179954.16	.	BCM	GRCh38.p13	chr19	55517742	55517742	+	G	G	A	Missense_Mutation	SNP	ENST00000389623.11	exon14	c.G3466A	p.D1156N	exonic	ENSG00000179954.16	.	nonsynonymous SNV	ENSG00000179954.16:ENST00000389623.11:exon14:c.G3466A:p.D1156N	19q13.42	C3N-03061	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.056	T	T	T	0.078	0.180	0.030	0.014	T	T	T	T	T	T	-0.558	0.090	0.871	N	N	-1.567	0.063	-1.676	0.056	1.000	0.609	0.492	0.769	0.445	.	1.650	-3.300	-2.011	-0.435	-0.386	0.000	0.001	0.023	958	.	.	.	.	SSC5D	114	0	143	36	0.201117318435754	NA	TRUE
ENSG00000179954.16	.	BCM	GRCh38.p13	chr19	55518413	55518413	+	G	G	C	Missense_Mutation	SNP	ENST00000389623.11	exon14	c.G4137C	p.Q1379H	exonic	ENSG00000179954.16	.	nonsynonymous SNV	ENSG00000179954.16:ENST00000389623.11:exon14:c.G4137C:p.Q1379H	19q13.42	C3N-03061	.	.	.	.	.	.	.	.	.	4.19	D	D	P	B	.	N	M	T	N	0.063	T	T	D	0.106	0.084	0.061	0.014	T	T	T	T	T	T	0.157	2.648	0.208	N	N	-0.928	0.486	-1.066	0.411	0.999	0.646	0.588	0.645	0.655	.	2.620	1.530	-0.057	0.205	-0.250	0.000	0.011	0.019	958	.	.	.	.	SSC5D	305	0	349	52	0.129675810473815	TRUE	TRUE
ENSG00000179873.14	.	BCM	GRCh38.p13	chr19	55817992	55817992	+	C	C	G	Missense_Mutation	SNP	ENST00000589093.5	exon2	c.G183C	p.E61D	exonic	ENSG00000179873.14	.	nonsynonymous SNV	ENSG00000179873.14:ENST00000589093.5:exon2:c.G183C:p.E61D	19q13.43	C3N-03061	.	.	.	.	.	.	.	.	.	1.17	.	D	P	P	.	N	L	T	.	0.232	T	T	T	0.070	0.469	0.598	.	T	T	T	T	T	T	0.862	10.040	0.995	N	N	-0.513	1.151	-0.751	0.827	0.002	0.487	0.492	0.574	0.564	.	2.840	0.573	-0.122	-0.843	-0.200	0.005	0.004	0.005	792	DAPIN_domain	.	.	.	NLRP11	163	0	184	16	0.08	TRUE	TRUE
ENSG00000179873.14	.	BCM	GRCh38.p13	chr19	55818024	55818024	+	C	C	G	Missense_Mutation	SNP	ENST00000589093.5	exon2	c.G151C	p.E51Q	exonic	ENSG00000179873.14	.	nonsynonymous SNV	ENSG00000179873.14:ENST00000589093.5:exon2:c.G151C:p.E51Q	19q13.43	C3N-03061	.	.	.	.	.	.	.	.	.	0.17	.	T	B	B	.	N	L	T	.	0.082	T	T	T	0.040	0.611	0.423	.	T	T	T	T	T	T	-0.023	1.201	0.696	N	N	-1.257	0.190	-1.314	0.200	0.069	0.487	0.492	0.574	0.564	.	2.840	-0.873	0.088	-0.863	-0.905	0.000	0.000	0.000	792	DAPIN_domain	.	.	.	NLRP11	183	0	214	18	0.0775862068965517	TRUE	TRUE
ENSG00000179873.14	.	BCM	GRCh38.p13	chr19	55818147	55818147	+	C	C	G	Missense_Mutation	SNP	ENST00000589093.5	exon2	c.G28C	p.D10H	exonic	ENSG00000179873.14	.	nonsynonymous SNV	ENSG00000179873.14:ENST00000589093.5:exon2:c.G28C:p.D10H	19q13.43	C3N-03061	.	.	.	.	.	.	.	.	.	3.17	.	D	D	D	.	N	N	T	.	0.179	T	T	T	0.131	0.583	0.528	.	T	T	T	T	T	T	2.120	20.300	0.987	N	N	-0.329	1.545	-0.573	1.087	0.099	0.487	0.480	0.574	0.564	.	2.560	1.460	0.493	0.583	0.580	0.000	0.209	0.051	792	DAPIN_domain	.	.	.	NLRP11	69	0	90	8	0.0816326530612245	TRUE	TRUE
ENSG00000124207.17	.	BCM	GRCh38.p13	chr20	49066199	49066199	+	A	A	G	Missense_Mutation	SNP	ENST00000262982.3	exon4	c.A236G	p.D79G	exonic	ENSG00000124207.17	.	nonsynonymous SNV	ENSG00000124207.17:ENST00000262982.3:exon4:c.A236G:p.D79G	20q13.13	C3N-03061	.	.	.	.	.	.	.	.	.	11.20	T	T	B	B	D	D	L	T	D	0.711	T	T	D	0.422	0.629	0.566	0.626	T	D	D	D	D	D	3.101	23.600	0.993	D	D	0.183	3.228	0.337	3.942	1.000	0.719	0.723	0.725	0.714	.	5.620	5.620	9.325	1.312	0.756	1.000	1.000	1.000	917	Importin-beta,_N-terminal_domain	.	.	.	CSE1L	132	0	158	21	0.11731843575419	TRUE	TRUE
ENSG00000124253.11	.	BCM	GRCh38.p13	chr20	57563084	57563084	+	C	C	T	Missense_Mutation	SNP	ENST00000319441.6	exon5	c.C667T	p.P223S	exonic	ENSG00000124253.11	.	nonsynonymous SNV	ENSG00000124253.11:ENST00000319441.6:exon5:c.C667T:p.P223S	20q13.31	C3N-03061	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	H	T	D	0.912	T	T	D	0.492	0.773	0.555	0.500	T	T	D	D	D	D	4.036	27.200	0.999	D	D	0.962	12.773	0.874	12.691	1.000	0.487	0.563	0.574	0.564	.	5.060	5.060	7.461	1.026	0.599	1.000	0.926	0.881	814	Phosphoenolpyruvate_carboxykinase,_GTP-utilising,_N-terminal	.	.	.	PCK1	227	0	212	32	0.131147540983607	TRUE	TRUE
ENSG00000125522.3	.	BCM	GRCh38.p13	chr20	64106189	64106189	+	A	A	G	Missense_Mutation	SNP	ENST00000369768.1	exon1	c.T643C	p.Y215H	exonic	ENSG00000125522.3	.	nonsynonymous SNV	ENSG00000125522.3:ENST00000369768.1:exon1:c.T643C:p.Y215H	20q13.33	C3N-03061	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	U	D	M	T	D	0.423	T	T	D	0.386	0.733	0.806	0.994	T	T	T	T	D	.	2.573	22.600	0.996	D	D	0.463	4.762	0.238	3.373	1.000	0.403	0.547	0.578	0.613	.	3.900	3.900	6.857	1.093	0.691	1.000	0.028	0.215	.	GPCR,_rhodopsin-like,_7TM	.	.	.	NPBWR2	162	0	176	24	0.12	TRUE	TRUE
ENSG00000180530.11	.	BCM	GRCh38.p13	chr21	14965093	14965093	+	A	A	T	Missense_Mutation	SNP	ENST00000318948.7	exon4	c.T3100A	p.S1034T	exonic	ENSG00000180530.11	.	nonsynonymous SNV	ENSG00000180530.11:ENST00000318948.7:exon4:c.T3100A:p.S1034T	21q11.2	C3N-03061	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	M	T	N	0.166	T	T	T	0.052	0.170	0.413	0.026	T	T	T	T	T	T	1.623	16.520	0.844	D	N	-0.666	0.872	-0.572	1.088	0.999	0.737	0.710	0.659	0.678	.	5.610	-0.186	0.606	0.272	0.756	0.999	0.240	0.975	994	Nuclear_receptor-interacting_protein_1,_repression_domain_4	.	.	.	NRIP1	134	0	172	14	0.0752688172043011	TRUE	TRUE
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	3052461	3052461	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000183117.19	ENST00000635120.2:exon50:c.7660+1G>A	.	.	8p23.2	C3N-03061	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.068	33	0.987	D	.	0.992	13.679	0.789	9.806	1.000	0.066	0.063	0.091	0.057	0.967	5.320	5.320	6.306	0.941	0.599	1.000	0.282	0.009	923	.	.	.	ID=COSV59289275;OCCURENCE=3(oesophagus),1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	CSMD1	66	0	76	8	0.0952380952380952	TRUE	TRUE
ENSG00000116981.3	.	BCM	GRCh38.p13	chr1	39659178	39659178	+	A	A	G	Silent	SNP	ENST00000235628.1	exon6	c.T1050C	p.G350G	exonic	ENSG00000116981.3	.	synonymous SNV	ENSG00000116981.3:ENST00000235628.1:exon6:c.T1050C:p.G350G	1p34.2	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52496025;OCCURENCE=1(stomach)	NT5C1A	175	0	114	31	0.213793103448276	TRUE	TRUE
ENSG00000117600.12	.	BCM	GRCh38.p13	chr1	99305912	99305912	+	C	C	A	Silent	SNP	ENST00000370185.7	exon7	c.C1194A	p.I398I	exonic	ENSG00000117600.12	.	synonymous SNV	ENSG00000117600.12:ENST00000370185.7:exon7:c.C1194A:p.I398I	1p21.2	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLPPR4	256	2	245	17	0.0648854961832061	TRUE	TRUE
ENSG00000134323.12	.	BCM	GRCh38.p13	chr2	15942721	15942721	+	C	C	T	Silent	SNP	ENST00000281043.4	exon2	c.C657T	p.V219V	exonic	ENSG00000134323.12	.	synonymous SNV	ENSG00000134323.12:ENST00000281043.4:exon2:c.C657T:p.V219V	2p24.3	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYCN	38	0	52	8	0.133333333333333	TRUE	TRUE
ENSG00000019169.10	.	BCM	GRCh38.p13	chr2	118994400	118994400	+	C	C	T	Silent	SNP	ENST00000327097.4	exon17	c.C1443T	p.I481I	exonic	ENSG00000019169.10	.	synonymous SNV	ENSG00000019169.10:ENST00000327097.4:exon17:c.C1443T:p.I481I	2q14.2	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MARCO	197	0	225	28	0.110671936758893	TRUE	TRUE
ENSG00000008300.17	.	BCM	GRCh38.p13	chr3	48661258	48661258	+	G	G	A	Silent	SNP	ENST00000164024.5	exon1	c.C1377T	p.D459D	exonic	ENSG00000008300.17	.	synonymous SNV	ENSG00000008300.17:ENST00000164024.5:exon1:c.C1377T:p.D459D	3p21.31	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CELSR3	163	0	144	34	0.191011235955056	TRUE	TRUE
ENSG00000048828.17	.	BCM	GRCh38.p13	chr9	93532214	93532214	+	C	C	A	Silent	SNP	ENST00000277165.11	exon10	c.C1794A	p.A598A	exonic	ENSG00000048828.17	.	synonymous SNV	ENSG00000048828.17:ENST00000277165.11:exon10:c.C1794A:p.A598A	9q22.31	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM120A	259	0	192	29	0.131221719457014	TRUE	TRUE
ENSG00000166341.8	.	BCM	GRCh38.p13	chr11	6626012	6626012	+	G	G	C	Silent	SNP	ENST00000299441.5	exon17	c.C6639G	p.S2213S	exonic	ENSG00000166341.8	.	synonymous SNV	ENSG00000166341.8:ENST00000299441.5:exon17:c.C6639G:p.S2213S	11p15.4	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DCHS1	259	0	251	26	0.0938628158844765	TRUE	TRUE
ENSG00000214517.10	.	BCM	GRCh38.p13	chr11	74230389	74230389	+	T	T	C	Silent	SNP	ENST00000328257.13	exon6	c.T543C	p.D181D	exonic	ENSG00000214517.10	.	synonymous SNV	ENSG00000214517.10:ENST00000328257.13:exon6:c.T543C:p.D181D	11q13.4	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60297014;OCCURENCE=1(large_intestine)	PPME1	232	0	279	43	0.133540372670807	TRUE	TRUE
ENSG00000111218.12	.	BCM	GRCh38.p13	chr12	3569518	3569518	+	C	C	T	Silent	SNP	ENST00000382622.4	exon6	c.C666T	p.Y222Y	exonic	ENSG00000111218.12	.	synonymous SNV	ENSG00000111218.12:ENST00000382622.4:exon6:c.C666T:p.Y222Y	12p13.32	C3N-03061	2.471e-05	0	8.637e-05	0	0	1.498e-05	0	6.056e-05	rs763610227	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99713579;OCCURENCE=1(large_intestine)	PRMT8	320	0	474	55	0.103969754253308	TRUE	NA
ENSG00000111262.6	.	BCM	GRCh38.p13	chr12	4912425	4912425	+	G	G	A	Silent	SNP	ENST00000382545.5	exon2	c.G1047A	p.A349A	exonic	ENSG00000111262.6	.	synonymous SNV	ENSG00000111262.6:ENST00000382545.5:exon2:c.G1047A:p.A349A	12p13.32	C3N-03061	3.295e-05	0	8.637e-05	0.0002	0	1.499e-05	0	0	rs748570236	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66836519;OCCURENCE=1(large_intestine),1(stomach),1(upper_aerodigestive_tract)	KCNA1	212	0	288	32	0.1	TRUE	TRUE
ENSG00000175548.9	.	BCM	GRCh38.p13	chr12	38318317	38318317	+	C	C	T	Silent	SNP	ENST00000308742.9	exon2	c.C228T	p.V76V	exonic	ENSG00000175548.9	.	synonymous SNV	ENSG00000175548.9:ENST00000308742.9:exon2:c.C228T:p.V76V	12q12	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ALG10B	407	1	489	79	0.139084507042254	NA	TRUE
ENSG00000261308.2	.	BCM	GRCh38.p13	chr12	51821751	51821751	+	C	C	T	Silent	SNP	ENST00000618634.2	exon2	c.G663A	p.P221P	exonic	ENSG00000261308.2	.	synonymous SNV	ENSG00000261308.2:ENST00000618634.2:exon2:c.G663A:p.P221P	12q13.13	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FIGNL2	23	0	38	9	0.191489361702128	TRUE	NA
ENSG00000132952.12	.	BCM	GRCh38.p13	chr13	30657646	30657646	+	C	C	T	Silent	SNP	ENST00000255304.9	exon9	c.C1569T	p.L523L	exonic	ENSG00000132952.12	.	synonymous SNV	ENSG00000132952.12:ENST00000255304.9:exon9:c.C1569T:p.L523L	13q12.3	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	USPL1	194	0	187	35	0.157657657657658	TRUE	TRUE
ENSG00000133101.10	.	BCM	GRCh38.p13	chr13	36438818	36438818	+	C	C	T	Silent	SNP	ENST00000255465.7	exon5	c.C844T	p.L282L	exonic	ENSG00000133101.10	.	synonymous SNV	ENSG00000133101.10:ENST00000255465.7:exon5:c.C844T:p.L282L	13q13.3	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCNA1	292	0	279	54	0.162162162162162	TRUE	TRUE
ENSG00000123191.16	.	BCM	GRCh38.p13	chr13	51937485	51937485	+	G	G	C	Silent	SNP	ENST00000242839.10	exon18	c.C3894G	p.V1298V	exonic	ENSG00000123191.16	.	synonymous SNV	ENSG00000123191.16:ENST00000242839.10:exon18:c.C3894G:p.V1298V	13q14.3	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP7B	672	0	745	105	0.123529411764706	TRUE	TRUE
ENSG00000123191.16	.	BCM	GRCh38.p13	chr13	51937572	51937572	+	G	G	T	Silent	SNP	ENST00000242839.10	exon18	c.C3807A	p.V1269V	exonic	ENSG00000123191.16	.	synonymous SNV	ENSG00000123191.16:ENST00000242839.10:exon18:c.C3807A:p.V1269V	13q14.3	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP7B	610	2	728	106	0.127098321342926	TRUE	TRUE
ENSG00000102935.11	.	BCM	GRCh38.p13	chr16	49637328	49637328	+	G	G	A	Silent	SNP	ENST00000561648.5	exon5	c.C1824T	p.S608S	exonic	ENSG00000102935.11	.	synonymous SNV	ENSG00000102935.11:ENST00000561648.5:exon5:c.C1824T:p.S608S	16q12.1	C3N-03061	9.892e-05	9.621e-05	0	0	0	7.5e-05	0.0011	0.0003	rs376218086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF423	230	1	238	33	0.121771217712177	TRUE	NA
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11854032	11854032	+	C	C	T	Silent	SNP	ENST00000262442.9	exon50	c.C9537T	p.G3179G	exonic	ENSG00000007174.18	.	synonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon50:c.C9537T:p.G3179G	17p12	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH9	152	0	184	23	0.111111111111111	TRUE	TRUE
ENSG00000141564.15	.	BCM	GRCh38.p13	chr17	80962997	80962997	+	C	C	T	Silent	SNP	ENST00000306801.8	exon33	c.C3879T	p.Y1293Y	exonic	ENSG00000141564.15	.	synonymous SNV	ENSG00000141564.15:ENST00000306801.8:exon33:c.C3879T:p.Y1293Y	17q25.3	C3N-03061	5.446e-05	0	0.0005	0	0	1.656e-05	0	0	rs781681867	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RPTOR	312	0	353	45	0.113065326633166	TRUE	NA
ENSG00000179954.16	.	BCM	GRCh38.p13	chr19	55518767	55518767	+	G	G	A	Silent	SNP	ENST00000389623.11	exon14	c.G4491A	p.V1497V	exonic	ENSG00000179954.16	.	synonymous SNV	ENSG00000179954.16:ENST00000389623.11:exon14:c.G4491A:p.V1497V	19q13.42	C3N-03061	5.263e-05	0	0	0	0	0.0001	0	0	rs775432888	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SSC5D	407	0	444	70	0.136186770428016	TRUE	NA
ENSG00000179954.16	.	BCM	GRCh38.p13	chr19	55518875	55518875	+	G	G	C	Silent	SNP	ENST00000389623.11	exon14	c.G4599C	p.R1533R	exonic	ENSG00000179954.16	.	synonymous SNV	ENSG00000179954.16:ENST00000389623.11:exon14:c.G4599C:p.R1533R	19q13.42	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SSC5D	382	0	465	72	0.134078212290503	TRUE	TRUE
ENSG00000088882.8	.	BCM	GRCh38.p13	chr20	2797971	2797971	+	G	G	A	Silent	SNP	ENST00000380605.3	exon5	c.C678T	p.D226D	exonic	ENSG00000088882.8	.	synonymous SNV	ENSG00000088882.8:ENST00000380605.3:exon5:c.C678T:p.D226D	20p13	C3N-03061	.	.	.	.	.	.	.	.	rs375748016	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPXM1	121	0	146	14	0.0875	TRUE	NA
ENSG00000124208.16	.	BCM	GRCh38.p13	chr20	50129586	50129586	+	C	C	T	Silent	SNP	ENST00000341698.2	exon4	c.G438A	p.P146P	exonic	ENSG00000124208.16;ENSG00000240849.11	.	synonymous SNV	ENSG00000124208.16:ENST00000341698.2:exon4:c.G438A:p.P146P,ENSG00000240849.11:ENST00000371652.9:exon4:c.G438A:p.P146P	20q13.13	C3N-03061	1.65e-05	0	0	0	0	1.5e-05	0	6.058e-05	rs150986496	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM189-UBE2V1	218	0	232	32	0.121212121212121	TRUE	NA
ENSG00000185340.15	.	BCM	GRCh38.p13	chr22	29311642	29311642	+	G	G	A	Silent	SNP	ENST00000618518.3	exon5	c.G1191A	p.R397R	exonic	ENSG00000185340.15	.	synonymous SNV	ENSG00000185340.15:ENST00000618518.3:exon5:c.G1191A:p.R397R	22q12.2	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GAS2L1	159	0	170	28	0.141414141414141	TRUE	NA
ENSG00000147100.11	.	BCM	GRCh38.p13	chrX	74421712	74421712	+	G	G	T	Silent	SNP	ENST00000587091.6	exon1	c.G75T	p.P25P	exonic	ENSG00000147100.11	.	synonymous SNV	ENSG00000147100.11:ENST00000587091.6:exon1:c.G75T:p.P25P	Xq13.2	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC16A2	470	0	398	74	0.156779661016949	TRUE	TRUE
ENSG00000185008.17	.	BCM	GRCh38.p13	chr3	77632578	77632578	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000185008.17	.	.	.	3p12.3	C3N-03061	0.0002	0.0036	0	0	0	0	0	0	rs753114815	3.15	T	T	B	B	.	.	.	T	N	0.237	T	T	T	0.040	0.241	0.329	.	.	.	T	T	T	D	2.124	20.300	0.980	D	D	-0.141	2.048	0.025	2.447	0.000	0.554	0.574	0.618	0.564	.	5.490	3.670	4.812	1.176	0.676	1.000	1.000	0.995	571	.	.	.	.	ROBO2	120	0	113	19	0.143939393939394	TRUE	NA
ENSG00000129055.12	.	BCM	GRCh38.p13	chr3	134478588	134478588	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000129055.12	ENST00000510994.5:c.*2G>A	.	.	3q22.2	C3N-03061	9.062e-05	0.0008	0.0002	0	0	1.499e-05	0	0	rs151170068	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANAPC13	89	0	76	14	0.155555555555556	TRUE	NA
ENSG00000172432.19	.	BCM	GRCh38.p13	chr6	43622000	43622000	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000172432.19	.	.	.	6p21.1	C3N-03061	0.0001	0	0	0	0	0	0	0.0008	rs112143094	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GTPBP2	487	0	529	67	0.11241610738255	TRUE	NA
ENSG00000216854.2	.	BCM	GRCh38.p13	chr6	56900474	56900474	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000216854.2;ENSG00000200224.2	dist=28731;dist=45256	.	.	6p12.1	C3N-03061	.	.	.	.	.	.	.	.	.	3.4	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.975	36	0.998	D	N	0.747	7.828	0.606	6.295	1.000	0.651	0.588	0.651	0.621	.	4.800	4.800	3.787	1.176	0.676	1.000	0.996	0.983	351	.	.	.	.	RPL17P26	259	0	318	26	0.0755813953488372	TRUE	TRUE
ENSG00000153930.12	.	BCM	GRCh38.p13	chr17	56492249	56492249	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000153930.12;ENSG00000243058.1	dist=9603;dist=80791	.	.	17q22	C3N-03061	.	.	.	.	.	.	.	.	.	6.10	.	D	.	.	.	D	.	T	.	0.771	.	.	D	.	.	0.742	.	.	T	T	T	.	D	4.082	27.600	0.998	D	D	.	.	.	.	1.000	0.487	0.590	0.574	0.530	.	5.540	5.540	9.402	1.176	0.618	1.000	1.000	0.998	95	.	.	.	.	ANKFN1	205	0	187	31	0.142201834862385	TRUE	TRUE
ENSG00000105705.16	.	BCM	GRCh38.p13	chr19	19303991	19303991	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000105705.16	.	.	.	19p13.11	C3N-03061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUGP1	54	0	51	9	0.15	TRUE	NA
ENSG00000130985.17	.	BCM	GRCh38.p13	chrX	47198245	47198245	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000130985.17	.	.	.	Xp11.3	C3N-03061	9.145e-05	0	0	0	0	0	0	0.0002	rs782182393	1.12	D	.	.	.	.	N	.	T	N	.	T	T	.	0.062	0.217	0.315	.	.	T	T	T	T	T	-0.066	0.974	0.480	N	.	.	.	.	.	0.999	.	.	.	.	.	1.810	-0.247	-0.155	-1.977	-0.813	0.000	0.000	0.002	465	.	.	.	.	UBA1	157	0	157	22	0.122905027932961	TRUE	NA
ENSG00000171612.7	.	BCM	GRCh38.p13	chr1	9539717	9539717	+	A	A	G	Missense_Mutation	SNP	ENST00000302692.7	exon1	c.A26G	p.E9G	exonic	ENSG00000171612.7	.	nonsynonymous SNV	ENSG00000171612.7:ENST00000302692.7:exon1:c.A26G:p.E9G	1p36.22	C3L-04848	.	.	.	.	.	.	.	.	.	6.20	D	T	B	B	U	D	N	T	N	0.209	T	T	D	0.210	0.361	0.558	0.534	D	T	T	T	D	T	3.659	25.200	0.995	D	N	-0.363	1.466	-0.220	1.739	1.000	0.243	0.484	0.391	0.492	.	3.350	3.350	1.127	1.174	0.551	1.000	1.000	0.985	912	.	.	.	.	SLC25A33	173	0	233	16	0.0642570281124498	NA	TRUE
ENSG00000068781.21	.	BCM	GRCh38.p13	chr2	48646790	48646790	+	C	C	G	Missense_Mutation	SNP	ENST00000403751.8	exon6	c.C726G	p.I242M	exonic	ENSG00000068781.21;ENSG00000242441.8	.	nonsynonymous SNV	ENSG00000242441.8:ENST00000403751.8:exon6:c.C726G:p.I242M,ENSG00000068781.21:ENST00000394754.5:exon8:c.C2838G:p.I946M	2p16.3	C3L-04848	8.237e-06	9.612e-05	0	0	0	0	0	0	rs149659316	0.20	T	T	B	B	N	N	L	T	N	0.130	T	T	T	0.123	.	0.030	0.007	T	T	T	T	T	T	0.438	5.844	0.325	N	N	-1.069	0.335	-1.089	0.387	0.000	0.554	0.574	0.618	0.621	.	4.880	-0.564	0.073	1.026	0.549	0.000	0.043	0.129	534	.	.	.	.	STON1-GTF2A1L	234	0	345	43	0.110824742268041	TRUE	NA
ENSG00000066032.18	.	BCM	GRCh38.p13	chr2	79909792	79909792	+	A	A	C	Missense_Mutation	SNP	ENST00000402739.8	exon6	c.A1051C	p.N351H	exonic	ENSG00000066032.18	.	nonsynonymous SNV	ENSG00000066032.18:ENST00000402739.8:exon6:c.A1051C:p.N351H	2p12	C3L-04848	.	.	.	.	.	.	.	.	.	9.20	D	T	D	P	N	D	L	T	D	0.449	T	T	D	0.120	0.460	0.556	1.366	D	T	T	T	T	D	3.311	24.200	0.997	D	D	0.557	5.516	0.557	5.726	0.971	0.615	0.574	0.659	0.564	.	5.600	5.600	2.853	1.312	0.691	1.000	1.000	0.995	981	.	.	.	ID=COSV63547281;OCCURENCE=1(ovary),1(soft_tissue),1(prostate),2(upper_aerodigestive_tract),1(endometrium)	CTNNA2	141	0	198	65	0.247148288973384	NA	TRUE
ENSG00000163702.20	.	BCM	GRCh38.p13	chr3	9933171	9933171	+	T	T	-	Frame_Shift_Del	NA	ENST00000295981.7	exon19	c.1954delT	p.F652Sfs*142	exonic	ENSG00000163702.20	.	frameshift deletion	ENSG00000163702.20:ENST00000295981.7:exon19:c.1954delT:p.F652Sfs*142	3p25.3	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IL17RC	152	0	248	24	0.0882352941176471	NA	TRUE
ENSG00000173585.16	.	BCM	GRCh38.p13	chr3	45901731	45901731	+	G	G	A	Missense_Mutation	SNP	ENST00000357632.7	exon3	c.G943A	p.V315I	exonic	ENSG00000173585.16	.	nonsynonymous SNV	ENSG00000173585.16:ENST00000357632.7:exon3:c.G943A:p.V315I	3p21.31	C3L-04848	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	L	T	N	0.026	T	T	T	0.077	0.321	0.458	0.261	T	T	T	T	D	T	1.185	13.520	0.996	D	N	-0.188	1.909	-0.059	2.168	1.000	0.635	0.644	0.547	0.542	.	4.960	4.960	0.741	1.176	0.676	0.373	0.942	0.974	484	GPCR,_rhodopsin-like,_7TM	.	.	.	CCR9	133	0	260	20	0.0714285714285714	TRUE	TRUE
ENSG00000236980.10	.	BCM	GRCh38.p13	chr3	49178025	49178025	+	C	C	T	Missense_Mutation	SNP	ENST00000545770.7	exon4	c.G226A	p.G76R	exonic	ENSG00000236980.10	.	nonsynonymous SNV	ENSG00000236980.10:ENST00000545770.7:exon4:c.G226A:p.G76R	3p21.31	C3L-04848	9.439e-06	0	0	0	0	1.674e-05	0	0	rs754289775	7.13	D	D	.	.	.	D	M	T	D	0.608	.	.	D	.	.	0.880	0.538	.	T	T	T	.	T	3.191	23.800	0.998	D	N	.	.	.	.	0.981	0.497	0.590	0.578	0.646	.	4.900	4.030	1.395	0.128	-0.175	0.990	0.988	0.977	0	Domain_of_unknown_function_with_conserved_HDNR_motif	.	.	ID=COSV60412884;OCCURENCE=1(large_intestine)	C3orf84	105	0	152	18	0.105882352941176	TRUE	TRUE
ENSG00000127249.15	.	BCM	GRCh38.p13	chr3	193464975	193464975	+	C	C	T	Missense_Mutation	SNP	ENST00000342695.9	exon12	c.G1426A	p.V476I	exonic	ENSG00000127249.15	.	nonsynonymous SNV	ENSG00000127249.15:ENST00000342695.9:exon12:c.G1426A:p.V476I	3q29	C3L-04848	1.648e-05	0	0	0.0001	0	1.499e-05	0	0	rs759539336	3.20	T	T	B	B	N	D	N	D	N	0.172	T	T	T	0.191	0.481	0.567	0.093	T	T	T	T	T	T	0.761	9.013	0.071	D	N	-0.721	0.778	-0.556	1.113	0.000	0.487	0.574	0.574	0.564	.	6.170	3.080	0.796	1.026	0.599	0.982	0.989	0.887	940	.	.	.	ID=COSV55066550;OCCURENCE=1(large_intestine)	ATP13A4	197	0	258	19	0.0685920577617329	TRUE	TRUE
ENSG00000164190.19	.	BCM	GRCh38.p13	chr5	37006360	37006360	+	A	A	G	Missense_Mutation	SNP	ENST00000282516.13	exon17	c.A3859G	p.N1287D	exonic	ENSG00000164190.19	.	nonsynonymous SNV	ENSG00000164190.19:ENST00000282516.13:exon17:c.A3859G:p.N1287D	5p13.2	C3L-04848	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	D	D	L	T	N	0.358	T	T	T	0.093	0.282	0.613	1.776	D	T	T	T	D	D	2.179	20.700	0.986	D	D	-0.221	1.819	-0.006	2.340	1.000	0.707	0.725	0.659	0.714	.	5.610	5.610	4.545	1.312	0.754	1.000	0.996	0.942	128	.	.	.	.	NIPBL	147	0	252	25	0.0902527075812274	TRUE	TRUE
ENSG00000203909.4	.	BCM	GRCh38.p13	chr6	73353909	73353909	+	C	C	T	Missense_Mutation	SNP	ENST00000370370.4	exon2	c.G236A	p.R79Q	exonic	ENSG00000203909.4	.	nonsynonymous SNV	ENSG00000203909.4:ENST00000370370.4:exon2:c.G236A:p.R79Q	6q13	C3L-04848	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	D	N	M	T	N	0.410	T	T	T	0.042	0.651	0.076	0.954	T	T	T	T	T	T	1.075	12.520	0.983	N	N	-0.687	0.835	-0.789	0.774	0.001	0.646	0.588	0.645	0.542	.	3.740	1.950	0.827	0.804	0.465	0.053	0.066	0.004	852	KH-like_RNA-binding_domain	.	.	ID=COSV64875412;OCCURENCE=2(large_intestine)	DPPA5	217	0	397	39	0.0894495412844037	NA	TRUE
ENSG00000077782.21	.	BCM	GRCh38.p13	chr8	38457373	38457373	+	G	G	-	Frame_Shift_Del	NA	ENST00000447712.7	exon2	c.74delC	p.P25Rfs*78	exonic	ENSG00000077782.21	.	frameshift deletion	ENSG00000077782.21:ENST00000447712.7:exon2:c.74delC:p.P25Rfs*78	8p11.23	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FGFR1	341	0	505	72	0.124783362218371	TRUE	TRUE
ENSG00000164796.18	.	BCM	GRCh38.p13	chr8	112304867	112304867	+	C	C	T	Nonsense_Mutation	SNP	ENST00000297405.10	exon52	c.G8120A	p.W2707X	exonic	ENSG00000164796.18	.	stopgain	ENSG00000164796.18:ENST00000297405.10:exon52:c.G8120A:p.W2707X	8q23.3	C3L-04848	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.566	.	.	.	.	.	.	.	.	.	D	D	.	.	8.761	45	0.996	D	N	0.982	13.377	0.859	12.099	1.000	0.487	0.574	0.574	0.564	.	5.180	5.180	7.879	1.026	0.599	1.000	1.000	0.999	849	Sushi/SCR/CCP_domain	.	.	ID=COSV52126876;OCCURENCE=1(cervix)	CSMD3	339	0	527	29	0.052158273381295	TRUE	NA
ENSG00000147799.11	.	BCM	GRCh38.p13	chr8	144547273	144547273	+	C	C	T	Missense_Mutation	SNP	ENST00000276826.5	exon4	c.G1813A	p.E605K	exonic	ENSG00000147799.11	.	nonsynonymous SNV	ENSG00000147799.11:ENST00000276826.5:exon4:c.G1813A:p.E605K	8q24.3	C3L-04848	.	.	.	.	.	.	.	.	.	11.20	T	T	D	D	N	D	M	T	N	0.750	T	T	D	0.237	0.392	0.772	1.225	T	T	D	D	D	D	3.299	24.100	0.999	D	D	0.437	4.580	0.434	4.611	1.000	0.646	0.547	0.645	0.700	.	5.050	5.050	3.769	1.026	0.599	1.000	0.910	0.855	878	.	.	.	.	ARHGAP39	290	0	431	75	0.148221343873518	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971187	21971187	+	G	G	-	Frame_Shift_Del	NA	ENST00000304494.9	exon2	c.172delC	p.R58Efs*88	exonic	ENSG00000147889.17	.	frameshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.172delC:p.R58Efs*88	9p21.3	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	487	0	645	96	0.129554655870445	NA	TRUE
ENSG00000148337.21	.	BCM	GRCh38.p13	chr9	128180487	128180487	+	T	T	C	Missense_Mutation	SNP	ENST00000372938.10	exon7	c.A719G	p.K240R	exonic	ENSG00000148337.21	.	nonsynonymous SNV	ENSG00000148337.21:ENST00000372938.10:exon7:c.A719G:p.K240R	9q34.11	C3L-04848	.	.	.	.	.	.	.	.	.	1.20	D	T	P	B	N	N	L	T	N	0.147	T	T	T	0.015	0.323	0.527	0.293	T	T	T	T	T	T	1.227	13.850	0.977	N	N	-0.590	1.005	-0.617	1.021	0.998	0.707	0.725	0.725	0.714	.	4.210	3.140	0.687	0.200	0.665	0.221	0.006	0.019	451	.	.	.	.	CIZ1	175	0	315	27	0.0789473684210526	TRUE	TRUE
ENSG00000110148.10	.	BCM	GRCh38.p13	chr11	6270255	6270255	+	G	G	A	Missense_Mutation	SNP	ENST00000334619.7	exon3	c.G571A	p.V191M	exonic	ENSG00000110148.10	.	nonsynonymous SNV	ENSG00000110148.10:ENST00000334619.7:exon3:c.G571A:p.V191M	11p15.4	C3L-04848	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	N	0.526	D	T	D	0.444	0.541	0.810	1.044	T	T	D	T	D	D	3.400	24.400	0.998	N	N	0.465	4.776	0.392	4.302	1.000	0.778	0.616	0.854	0.584	.	4.810	4.810	0.686	1.176	0.676	0.223	0.948	0.885	595	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58099194;OCCURENCE=1(cervix),1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	CCKBR	300	0	422	59	0.122661122661123	TRUE	TRUE
ENSG00000186714.12	.	BCM	GRCh38.p13	chr11	32654942	32654942	+	T	T	G	Missense_Mutation	SNP	ENST00000335185.9	exon10	c.A676C	p.K226Q	exonic	ENSG00000186714.12	.	nonsynonymous SNV	ENSG00000186714.12:ENST00000335185.9:exon10:c.A676C:p.K226Q	11p13	C3L-04848	.	.	.	.	.	.	.	.	.	7.18	D	T	D	D	.	N	M	.	N	0.451	T	T	T	0.086	0.179	0.327	0.558	T	T	T	T	D	T	3.636	25.200	0.992	D	D	0.583	5.755	0.578	5.955	0.412	0.487	0.574	0.574	0.564	.	5.670	5.670	5.175	1.138	0.609	1.000	0.997	0.856	368	.	.	.	.	CCDC73	122	0	210	19	0.0829694323144105	TRUE	TRUE
ENSG00000110436.13	.	BCM	GRCh38.p13	chr11	35265741	35265741	+	G	G	A	Missense_Mutation	SNP	ENST00000278379.9	exon10	c.C1439T	p.S480L	exonic	ENSG00000110436.13	.	nonsynonymous SNV	ENSG00000110436.13:ENST00000278379.9:exon10:c.C1439T:p.S480L	11p13	C3L-04848	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.952	T	T	D	0.589	0.592	0.824	1.372	D	D	D	D	D	D	4.148	28.200	0.998	D	D	0.544	5.396	0.559	5.745	1.000	0.603	0.575	0.602	0.663	.	5.690	5.690	9.516	1.176	0.676	1.000	0.998	0.951	521	.	.	.	.	SLC1A2	121	0	151	11	0.0679012345679012	TRUE	TRUE
ENSG00000255012.2	.	BCM	GRCh38.p13	chr11	56613139	56613139	+	G	G	A	Missense_Mutation	SNP	ENST00000641076.1	exon2	c.C364T	p.R122C	exonic	ENSG00000255012.2	.	nonsynonymous SNV	ENSG00000255012.2:ENST00000641076.1:exon2:c.C364T:p.R122C	11q12.1	C3L-04848	7.46e-05	0	0.0006	0	0	0	0	0.0001	rs189610087	7.20	D	D	P	B	N	D	M	T	D	0.558	T	T	D	0.419	.	0.845	0.455	T	T	T	T	T	T	1.809	17.800	0.993	D	N	-0.061	2.300	-0.089	2.077	0.000	0.487	0.574	0.574	0.564	.	3.710	2.770	0.195	0.122	0.302	0.036	0.002	0.880	306	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV73202421;OCCURENCE=3(skin)	OR5M1	228	0	256	19	0.0690909090909091	NA	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-04848	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	274	0	418	62	0.129166666666667	TRUE	TRUE
ENSG00000139174.12	.	BCM	GRCh38.p13	chr12	42460281	42460281	+	C	C	T	Missense_Mutation	SNP	ENST00000345127.9	exon8	c.G2024A	p.R675H	exonic	ENSG00000139174.12	.	nonsynonymous SNV	ENSG00000139174.12:ENST00000345127.9:exon8:c.G2024A:p.R675H	12q12	C3L-04848	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	N	D	N	0.164	T	T	D	0.276	0.185	0.394	0.436	T	T	T	T	T	D	1.918	18.630	0.970	D	N	-0.391	1.402	-0.253	1.663	0.985	0.722	0.588	0.699	0.711	.	5.530	3.320	1.717	-0.214	-0.172	1.000	0.957	0.989	503	.	.	.	ID=COSV58207605;OCCURENCE=1(oesophagus),2(large_intestine),1(stomach)	PRICKLE1	489	0	641	97	0.131436314363144	TRUE	TRUE
ENSG00000135127.11	.	BCM	GRCh38.p13	chr12	119998656	119998656	+	C	C	T	Missense_Mutation	SNP	ENST00000397558.6	exon2	c.C565T	p.R189W	exonic	ENSG00000135127.11	.	nonsynonymous SNV	ENSG00000135127.11:ENST00000397558.6:exon2:c.C565T:p.R189W	12q24.23	C3L-04848	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	.	T	D	0.221	T	T	T	0.172	0.209	0.802	0.491	T	T	D	D	D	D	3.793	25.800	0.999	D	D	0.675	6.788	0.638	6.741	1.000	0.706	0.710	0.710	0.530	.	5.040	5.040	2.284	1.026	0.599	0.987	0.997	1.000	820	.	.	.	.	BICDL1	265	0	309	52	0.14404432132964	TRUE	NA
ENSG00000178235.8	.	BCM	GRCh38.p13	chr13	83880697	83880697	+	G	G	A	Missense_Mutation	SNP	ENST00000377084.3	exon1	c.C811T	p.L271F	exonic	ENSG00000178235.8	.	nonsynonymous SNV	ENSG00000178235.8:ENST00000377084.3:exon1:c.C811T:p.L271F	13q31.1	C3L-04848	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	D	D	L	T	N	0.339	T	T	T	0.073	0.263	0.165	1.023	T	T	T	T	D	D	2.902	23.200	0.985	D	N	0.130	3.007	0.215	3.260	0.990	0.767	0.547	0.851	0.564	.	4.710	4.710	3.077	1.176	0.676	1.000	1.000	0.997	973	.	.	.	.	SLITRK1	154	0	256	24	0.0857142857142857	TRUE	TRUE
ENSG00000179455.9	.	BCM	GRCh38.p13	chr15	23566993	23566993	+	C	C	T	Missense_Mutation	SNP	ENST00000314520.6	exon1	c.C1211T	p.A404V	exonic	ENSG00000179455.9	.	nonsynonymous SNV	ENSG00000179455.9:ENST00000314520.6:exon1:c.C1211T:p.A404V	15q11.2	C3L-04848	2.471e-05	0	0	0	0	1.498e-05	0	0.0001	rs776896408	3.19	T	T	D	B	D	D	L	T	N	0.169	T	T	T	0.099	0.329	0.631	0.089	T	T	T	T	T	T	1.467	15.530	0.893	N	.	-0.537	1.105	-0.663	0.953	1.000	0.554	0.574	0.574	0.621	.	4.010	0.897	2.226	0.063	0.599	0.954	0.719	0.658	994	Zinc_finger,_CCCH-type	.	.	.	MKRN3	423	1	600	81	0.118942731277533	TRUE	NA
ENSG00000161996.19	.	BCM	GRCh38.p13	chr16	651088	651088	+	G	G	A	Missense_Mutation	SNP	ENST00000293879.9	exon6	c.G653A	p.R218H	exonic	ENSG00000161996.19	.	nonsynonymous SNV	ENSG00000161996.19:ENST00000293879.9:exon6:c.G653A:p.R218H	16p13.3	C3L-04848	6.672e-05	0.0001	0	0	0	0.0001	0	0	rs778872146	1.20	T	T	B	B	N	D	N	T	N	0.103	T	T	T	0.036	0.682	0.014	0.142	T	T	T	T	T	T	-0.365	0.227	0.900	N	N	-1.501	0.081	-1.563	0.086	1.000	0.635	0.644	0.723	0.700	.	4.950	-4.990	-0.807	-0.775	-0.633	0.000	0.004	0.007	649	.	.	.	.	WDR90	275	0	488	60	0.109489051094891	TRUE	NA
ENSG00000103174.13	.	BCM	GRCh38.p13	chr16	5028045	5028045	+	C	C	T	Missense_Mutation	SNP	ENST00000312251.8	exon6	c.G1061A	p.G354D	exonic	ENSG00000103174.13	.	nonsynonymous SNV	ENSG00000103174.13:ENST00000312251.8:exon6:c.G1061A:p.G354D	16p13.3	C3L-04848	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.859	D	D	D	0.380	0.925	0.806	0.141	T	D	T	T	D	T	2.428	22.200	0.998	D	D	0.638	6.338	0.422	4.517	1.000	0.660	0.694	0.723	0.655	.	4.030	4.030	4.691	1.026	0.599	0.998	0.005	0.001	867	.	.	.	.	NAGPA	481	0	867	50	0.054525627044711	TRUE	TRUE
ENSG00000273559.5	.	BCM	GRCh38.p13	chr17	38802836	38802836	+	G	G	A	Nonsense_Mutation	SNP	ENST00000614790.5	exon9	c.C1027T	p.R343X	exonic	ENSG00000273559.5	.	stopgain	ENSG00000273559.5:ENST00000614790.5:exon9:c.C1027T:p.R343X	17q12	C3L-04848	1.656e-05	0	0	0	0.0002	0	0	6.056e-05	rs760543725	4.6	.	.	.	.	N	A	.	.	.	0.275	.	.	.	.	.	.	.	.	.	D	D	.	.	7.705	39	0.997	D	N	0.706	7.200	0.578	5.963	1.000	0.707	0.725	0.725	0.714	.	5.880	4.900	1.554	1.176	0.676	0.984	0.998	0.997	352	.	.	.	.	CWC25	156	0	265	19	0.0669014084507042	TRUE	NA
ENSG00000101203.16	.	BCM	GRCh38.p13	chr20	63309378	63309378	+	C	C	T	Missense_Mutation	SNP	ENST00000358894.10	exon9	c.C986T	p.P329L	exonic	ENSG00000101203.16	.	nonsynonymous SNV	ENSG00000101203.16:ENST00000358894.10:exon9:c.C986T:p.P329L	20q13.33	C3L-04848	.	.	.	.	.	.	.	.	rs749535969	2.20	T	T	B	B	N	N	N	D	N	0.152	T	T	D	0.136	.	0.741	0.036	T	T	T	T	T	T	0.309	4.389	0.885	N	N	-1.066	0.338	-1.159	0.319	0.570	0.526	0.547	0.600	0.584	.	4.630	-4.100	-0.078	-0.590	0.450	0.001	0.000	0.008	.	von_Willebrand_factor,_type_A	.	.	ID=COSV58920416;OCCURENCE=1(large_intestine)	COL20A1	109	0	235	16	0.0637450199203187	TRUE	TRUE
ENSG00000183579.16	.	BCM	GRCh38.p13	chr22	29043419	29043419	+	C	C	T	Missense_Mutation	SNP	ENST00000544604.7	exon4	c.C622T	p.R208C	exonic	ENSG00000183579.16	.	nonsynonymous SNV	ENSG00000183579.16:ENST00000544604.7:exon4:c.C622T:p.R208C	22q12.1	C3L-04848	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	D	D	L	T	D	0.495	T	T	D	0.245	0.409	0.117	1.338	D	T	T	T	D	D	4.103	27.800	0.999	D	D	0.512	5.132	0.587	6.065	1.000	0.732	0.588	0.744	0.655	.	6.070	6.070	2.565	1.026	0.599	1.000	1.000	0.987	520	.	.	.	ID=COSV60430961;OCCURENCE=2(large_intestine),1(endometrium)	ZNRF3	124	0	205	16	0.0723981900452489	TRUE	TRUE
ENSG00000101825.8	.	BCM	GRCh38.p13	chrX	3322195	3322195	+	G	G	A	Missense_Mutation	SNP	ENST00000217939.7	exon5	c.C3490T	p.H1164Y	exonic	ENSG00000101825.8	.	nonsynonymous SNV	ENSG00000101825.8:ENST00000217939.7:exon5:c.C3490T:p.H1164Y	Xp22.33	C3L-04848	.	.	.	.	.	.	.	.	.	2.19	D	T	D	B	U	N	N	T	N	0.181	T	T	T	0.092	0.260	0.235	0.155	T	T	T	T	T	T	1.216	13.760	0.984	N	.	.	.	.	.	0.015	.	.	.	.	.	3.610	2.720	2.035	0.056	0.674	0.246	0.009	0.588	1000	.	.	.	ID=COSV54246826;OCCURENCE=1(skin)	MXRA5	66	0	58	4	0.0645161290322581	TRUE	NA
ENSG00000169891.18	.	BCM	GRCh38.p13	chrX	16946911	16946911	+	C	C	T	Missense_Mutation	SNP	ENST00000357277.8	exon1	c.C50T	p.A17V	exonic	ENSG00000169891.18	.	nonsynonymous SNV	ENSG00000169891.18:ENST00000357277.8:exon1:c.C50T:p.A17V	Xp22.2	C3L-04848	.	.	.	.	.	.	.	.	.	3.19	D	T	B	B	U	N	L	T	N	0.277	T	T	D	0.020	0.262	0.213	0.379	D	T	T	T	T	T	1.765	17.480	0.993	N	.	.	.	.	.	1.000	.	.	.	.	.	3.260	2.390	2.232	0.547	0.368	0.993	0.911	0.327	300	.	.	.	.	REPS2	11	0	20	4	0.166666666666667	NA	TRUE
ENSG00000175809.6	.	BCM	GRCh38.p13	chrX	22274099	22274099	+	G	G	A	Missense_Mutation	SNP	ENST00000323684.4	exon1	c.G1108A	p.E370K	exonic	ENSG00000175809.6	.	nonsynonymous SNV	ENSG00000175809.6:ENST00000323684.4:exon1:c.G1108A:p.E370K	Xp22.11	C3L-04848	.	.	.	.	.	.	.	.	rs868368528	5.18	D	T	D	P	U	N	.	T	N	0.201	T	T	T	0.141	0.526	0.030	0.445	T	T	T	T	D	D	2.095	19.980	0.974	D	.	.	.	.	.	0.009	.	.	.	.	.	2.900	2.030	2.881	0.190	-0.106	1.000	0.006	0.019	789	.	.	.	ID=COSV60370252;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(pancreas),1(skin)	CBLL2	242	0	304	29	0.0870870870870871	TRUE	TRUE
ENSG00000232030.3	.	BCM	GRCh38.p13	chrX	26161271	26161271	+	G	G	A	Missense_Mutation	SNP	ENST00000416929.2	exon1	c.G671A	p.R224H	exonic	ENSG00000232030.3	.	nonsynonymous SNV	ENSG00000232030.3:ENST00000416929.2:exon1:c.G671A:p.R224H	Xp21.3	C3L-04848	.	.	.	.	.	.	.	.	.	0.3	.	T	.	.	.	.	.	.	.	0.110	.	.	.	.	.	.	.	.	.	.	.	.	T	0.338	4.723	0.493	N	.	.	.	.	.	0.000	.	.	.	.	0.043	2.470	-3.170	0.482	-0.623	-0.154	0.000	0.000	0.002	611	MAGE_homology_domain	.	.	.	MAGEB6B	249	0	290	17	0.0553745928338762	TRUE	TRUE
ENSG00000183337.17	.	BCM	GRCh38.p13	chrX	40052112	40052112	+	C	C	T	Nonsense_Mutation	SNP	ENST00000378444.9	exon15	c.G5265A	p.W1755X	exonic	ENSG00000183337.17	.	stopgain	ENSG00000183337.17:ENST00000378444.9:exon15:c.G5265A:p.W1755X	Xp11.4	C3L-04848	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	0.582	.	.	.	.	.	.	.	.	.	D	D	.	.	8.279	42	0.984	D	.	.	.	.	.	1.000	.	.	.	.	.	5.830	5.830	1.899	1.026	0.599	1.000	0.293	0.469	912	.	.	.	.	BCOR	93	0	96	7	0.0679611650485437	TRUE	TRUE
ENSG00000102385.12	.	BCM	GRCh38.p13	chrX	101241722	101241722	+	C	C	T	Missense_Mutation	SNP	ENST00000395209.7	exon7	c.C614T	p.A205V	exonic	ENSG00000102385.12	.	nonsynonymous SNV	ENSG00000102385.12:ENST00000395209.7:exon7:c.C614T:p.A205V	Xq22.1	C3L-04848	1.144e-05	0	0	0	0	2.092e-05	0	0	rs755031248	5.19	T	T	P	B	D	D	L	T	N	0.838	T	T	D	0.184	0.322	0.268	0.939	T	T	T	T	T	D	1.892	18.430	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.490	5.490	7.527	1.026	0.599	1.000	0.984	0.870	124	.	.	.	ID=COSV65811879;OCCURENCE=1(large_intestine)	DRP2	212	0	332	22	0.0621468926553672	TRUE	TRUE
ENSG00000198354.7	.	BCM	GRCh38.p13	chrX	126165330	126165330	+	C	C	T	Missense_Mutation	SNP	ENST00000360028.4	exon1	c.G595A	p.A199T	exonic	ENSG00000198354.7	.	nonsynonymous SNV	ENSG00000198354.7:ENST00000360028.4:exon1:c.G595A:p.A199T	Xq25	C3L-04848	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	L	T	N	0.138	T	T	T	0.044	.	0.348	.	T	T	T	T	T	T	0.485	6.350	0.969	D	.	.	.	.	.	0.001	.	.	.	.	.	3.870	-0.260	1.065	-0.066	0.463	0.806	0.001	0.193	937	WD40-repeat-containing_domain	.	.	ID=COSV63580237;OCCURENCE=2(liver),1(stomach),1(kidney),1(skin),1(lung),1(upper_aerodigestive_tract)	DCAF12L2	443	0	715	40	0.0529801324503311	NA	TRUE
ENSG00000147255.19	.	BCM	GRCh38.p13	chrX	131286605	131286605	+	G	G	A	Missense_Mutation	SNP	ENST00000361420.8	exon2	c.C70T	p.R24W	exonic	ENSG00000147255.19	.	nonsynonymous SNV	ENSG00000147255.19:ENST00000361420.8:exon2:c.C70T:p.R24W	Xq26.1	C3L-04848	2.284e-05	0.0001	0	0	0	2.085e-05	0	0	rs767093474	2.18	T	T	B	B	.	D	N	T	N	0.183	T	T	D	0.050	.	0.043	0.193	T	T	T	T	T	T	0.326	4.585	0.743	N	.	.	.	.	.	1.000	.	.	.	.	.	4.240	-4.580	-1.217	-1.087	-0.817	0.013	0.926	0.871	73	.	.	.	ID=COSV63836910;OCCURENCE=1(large_intestine),1(NS),1(kidney),1(skin)	IGSF1	70	0	104	11	0.0956521739130435	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7670717	7670717	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon10:c.994-2A>G	.	.	17p13.1	C3L-04848	.	.	.	.	.	.	.	.	rs867389695	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.684	34	0.992	D	.	0.928	11.804	0.723	8.214	0.996	0.295	0.272	0.343	0.221	0.943	5.130	5.130	6.967	1.136	0.665	1.000	0.831	0.519	450	.	.	.	ID=COSV52692098;OCCURENCE=5(breast),1(liver),1(large_intestine),1(central_nervous_system),2(ovary),3(haematopoietic_and_lymphoid_tissue),3(prostate),5(lung),1(thyroid),1(upper_aerodigestive_tract)	TP53	273	0	351	60	0.145985401459854	TRUE	TRUE
ENSG00000081923.15	.	BCM	GRCh38.p13	chr18	57652483	57652483	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000081923.15	ENST00000648908.2:exon25:c.3261+1G>A	.	.	18q21.31	C3L-04848	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.322	33	0.995	D	.	1.162	20.769	1.014	19.724	1.000	0.070	0.097	0.084	0.090	0.990	5.860	5.860	7.876	1.026	0.599	1.000	0.966	0.790	982	.	.	.	.	ATP8B1	205	0	310	22	0.0662650602409639	TRUE	TRUE
ENSG00000138061.12	.	BCM	GRCh38.p13	chr2	38075035	38075035	+	C	C	T	Silent	SNP	ENST00000610745.5	exon2	c.G354A	p.P118P	exonic	ENSG00000138061.12	.	synonymous SNV	ENSG00000138061.12:ENST00000610745.5:exon2:c.G354A:p.P118P	2p22.2	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53192711;OCCURENCE=1(ovary)	CYP1B1	448	0	597	99	0.142241379310345	TRUE	TRUE
ENSG00000068781.21	.	BCM	GRCh38.p13	chr2	48646469	48646469	+	C	C	T	Silent	SNP	ENST00000403751.8	exon6	c.C405T	p.V135V	exonic	ENSG00000068781.21;ENSG00000242441.8	.	synonymous SNV	ENSG00000242441.8:ENST00000403751.8:exon6:c.C405T:p.V135V,ENSG00000068781.21:ENST00000394754.5:exon8:c.C2517T:p.V839V	2p16.3	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STON1-GTF2A1L	60	0	78	8	0.0930232558139535	TRUE	TRUE
ENSG00000121988.18	.	BCM	GRCh38.p13	chr2	135207530	135207530	+	G	G	A	Silent	SNP	ENST00000264159.11	exon19	c.C2913T	p.N971N	exonic	ENSG00000121988.18	.	synonymous SNV	ENSG00000121988.18:ENST00000264159.11:exon19:c.C2913T:p.N971N	2q21.3	C3L-04848	0.0007	0	0	0.0089	0	5.995e-05	0	6.057e-05	rs199874816	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZRANB3	153	0	235	18	0.0711462450592885	TRUE	NA
ENSG00000187091.13	.	BCM	GRCh38.p13	chr3	38009785	38009785	+	C	C	T	Silent	SNP	ENST00000334661.4	exon9	c.G1314A	p.K438K	exonic	ENSG00000187091.13	.	synonymous SNV	ENSG00000187091.13:ENST00000334661.4:exon9:c.G1314A:p.K438K	3p22.2	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLCD1	332	0	550	50	0.0833333333333333	TRUE	TRUE
ENSG00000121552.4	.	BCM	GRCh38.p13	chr3	122337567	122337567	+	A	A	G	Silent	SNP	ENST00000264474.4	exon2	c.A87G	p.E29E	exonic	ENSG00000121552.4	.	synonymous SNV	ENSG00000121552.4:ENST00000264474.4:exon2:c.A87G:p.E29E	3q21.1	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CSTA	135	0	221	27	0.108870967741935	TRUE	TRUE
ENSG00000039139.9	.	BCM	GRCh38.p13	chr5	13810183	13810183	+	C	C	T	Silent	SNP	ENST00000265104.4	exon45	c.G7485A	p.A2495A	exonic	ENSG00000039139.9	.	synonymous SNV	ENSG00000039139.9:ENST00000265104.4:exon45:c.G7485A:p.A2495A	5p15.2	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54231710;OCCURENCE=1(central_nervous_system)	DNAH5	201	0	429	58	0.119096509240246	TRUE	TRUE
ENSG00000177409.12	.	BCM	GRCh38.p13	chr7	93135711	93135711	+	C	C	T	Silent	SNP	ENST00000318238.9	exon5	c.G261A	p.P87P	exonic	ENSG00000177409.12	.	synonymous SNV	ENSG00000177409.12:ENST00000318238.9:exon5:c.G261A:p.P87P	7q21.2	C3L-04848	2.472e-05	0	0	0	0.0003	1.499e-05	0	0	rs767681806	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SAMD9L	256	0	351	51	0.126865671641791	TRUE	NA
ENSG00000164889.14	.	BCM	GRCh38.p13	chr7	151071418	151071418	+	G	G	A	Silent	SNP	ENST00000413384.7	exon14	c.G2004A	p.G668G	exonic	ENSG00000164889.14	.	synonymous SNV	ENSG00000164889.14:ENST00000413384.7:exon14:c.G2004A:p.G668G	7q36.1	C3L-04848	.	.	.	.	.	.	.	.	rs527345139	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC4A2	128	0	226	73	0.244147157190635	TRUE	NA
ENSG00000189376.12	.	BCM	GRCh38.p13	chr8	123241299	123241299	+	C	C	T	Silent	SNP	ENST00000276704.6	exon1	c.G48A	p.V16V	exonic	ENSG00000189376.12	.	synonymous SNV	ENSG00000189376.12:ENST00000276704.6:exon1:c.G48A:p.V16V	8q24.13	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C8orf76	178	0	334	26	0.0722222222222222	TRUE	TRUE
ENSG00000169727.12	.	BCM	GRCh38.p13	chr17	82056487	82056487	+	C	C	T	Silent	SNP	ENST00000306823.10	exon10	c.C1065T	p.D355D	exonic	ENSG00000169727.12	.	synonymous SNV	ENSG00000169727.12:ENST00000306823.10:exon10:c.C1065T:p.D355D	17q25.3	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPS1	201	0	369	35	0.0866336633663366	TRUE	TRUE
ENSG00000126091.21	.	BCM	GRCh38.p13	chr1	43930103	43930103	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000126091.21;ENSG00000284989.1	.	.	.	1p34.1	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ST3GAL3	504	0	693	92	0.117197452229299	TRUE	NA
ENSG00000163964.16	.	BCM	GRCh38.p13	chr3	196721182	196721182	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000163964.16	.	.	.	3q29	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PIGX	56	0	98	6	0.0576923076923077	TRUE	NA
ENSG00000164877.19	.	BCM	GRCh38.p13	chr7	1434376	1434376	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000164877.19	ENST00000297508.8:c.*220C>T	.	.	7p22.3	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MICALL2	130	0	196	29	0.128888888888889	TRUE	NA
ENSG00000019485.13	.	BCM	GRCh38.p13	chr11	45212897	45212897	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000019485.13	.	.	.	11p11.2	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRDM11	38	1	63	4	0.0597014925373134	TRUE	NA
ENSG00000196547.15	.	BCM	GRCh38.p13	chr15	90911372	90911372	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000196547.15	.	.	.	15q26.1	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAN2A2	141	0	209	12	0.0542986425339367	TRUE	NA
ENSG00000132507.18	.	BCM	GRCh38.p13	chr17	7310168	7310168	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000132507.18	.	.	.	17p13.1	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EIF5A	379	0	471	71	0.1309963099631	TRUE	NA
ENSG00000121073.15	.	BCM	GRCh38.p13	chr17	49704086	49704086	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000121073.15	.	.	.	17q21.33	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC35B1	119	0	183	27	0.128571428571429	TRUE	NA
ENSG00000089063.15	.	BCM	GRCh38.p13	chr20	5111525	5111525	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000089063.15	ENST00000379286.6:c.-2095G>A	.	.	20p12.3	C3L-04848	.	.	.	.	.	.	.	.	.	1.17	D	T	P	B	.	N	.	T	N	0.116	T	T	T	0.019	0.367	0.030	0.667	T	.	T	T	T	T	0.180	2.900	0.898	N	N	-0.789	0.671	-0.983	0.511	0.999	0.476	0.602	0.537	0.492	.	0.536	0.536	0.500	0.412	0.389	0.003	0.005	0.009	957	.	.	.	.	TMEM230	40	0	69	4	0.0547945205479452	TRUE	NA
ENSG00000068781.21	.	BCM	GRCh38.p13	chr2	48646517	48646518	+	TC	TC	AT	Unknown	MNP	ENST00000403751.8	exon6	c.453_454delinsAT	p.Q152_W478del	exonic	ENSG00000068781.21;ENSG00000242441.8	.	stopgain	ENSG00000242441.8:ENST00000403751.8:exon6:c.453_454delinsAT:p.Q152_W478del,ENSG00000068781.21:ENST00000394754.5:exon8:c.2565_2566delinsAT:p.Q856_W1182del	2p16.3	C3L-04848	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STON1-GTF2A1L	115	0	173	23	0.11734693877551	TRUE	NA
ENSG00000070886.12	.	BCM	GRCh38.p13	chr1	22601428	22601428	+	C	C	T	Missense_Mutation	SNP	ENST00000166244.8	exon16	c.C2858T	p.A953V	exonic	ENSG00000070886.12	.	nonsynonymous SNV	ENSG00000070886.12:ENST00000166244.8:exon16:c.C2858T:p.A953V	1p36.12	C3N-00514	.	.	.	.	.	.	.	.	rs369076646	8.20	D	T	D	B	D	D	M	T	N	0.590	T	T	T	0.116	.	0.593	0.525	T	T	T	T	D	D	3.014	23.400	0.999	D	N	0.263	3.596	0.249	3.433	0.900	0.581	0.574	0.576	0.542	.	5.230	5.230	1.172	1.012	0.545	0.442	0.897	0.694	888	Sterile_alpha_motif_domain	.	.	ID=COSV99385518;OCCURENCE=1(stomach)	EPHA8	463	0	1086	67	0.0581092801387684	TRUE	NA
ENSG00000162618.15	.	BCM	GRCh38.p13	chr1	78937815	78937815	+	G	G	A	Missense_Mutation	SNP	ENST00000370742.4	exon6	c.C752T	p.T251M	exonic	ENSG00000162618.15	.	nonsynonymous SNV	ENSG00000162618.15:ENST00000370742.4:exon6:c.C752T:p.T251M	1p31.1	C3N-00514	6.685e-05	0	0	0	0	7.538e-05	0	0.0002	rs369699141	6.19	D	D	D	P	N	D	.	T	N	0.284	T	T	T	0.100	.	0.368	0.223	T	T	T	T	T	D	3.095	23.600	0.998	D	N	0.009	2.543	0.015	2.410	0.007	0.707	0.574	0.574	0.714	.	5.790	3.900	1.974	-0.367	-0.227	1.000	0.706	0.822	775	GAIN_domain,_N-terminal	.	.	ID=COSV66059098;OCCURENCE=1(large_intestine),1(stomach)	ADGRL4	70	0	137	14	0.0927152317880795	TRUE	TRUE
ENSG00000119866.22	.	BCM	GRCh38.p13	chr2	60461723	60461723	+	G	G	A	Missense_Mutation	SNP	ENST00000642384.2	exon4	c.C1189T	p.R397C	exonic	ENSG00000119866.22	.	nonsynonymous SNV	ENSG00000119866.22:ENST00000642384.2:exon4:c.C1189T:p.R397C	2p16.1	C3N-00514	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.875	T	T	D	0.440	0.762	0.728	.	D	D	D	D	D	D	4.289	29.500	0.990	D	D	0.708	7.234	0.648	6.875	1.000	0.696	0.654	0.723	0.621	.	5.740	4.840	3.898	1.176	0.676	1.000	1.000	1.000	855	Zinc_finger_C2H2-type	.	.	ID=COSV59624433;OCCURENCE=1(large_intestine),1(stomach)	BCL11A	443	0	1028	79	0.0713640469738031	TRUE	TRUE
ENSG00000066032.18	.	BCM	GRCh38.p13	chr2	79909756	79909756	+	C	C	T	Missense_Mutation	SNP	ENST00000402739.8	exon6	c.C1015T	p.R339W	exonic	ENSG00000066032.18	.	nonsynonymous SNV	ENSG00000066032.18:ENST00000402739.8:exon6:c.C1015T:p.R339W	2p12	C3N-00514	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.876	T	T	D	0.468	0.669	0.797	1.666	D	D	D	D	D	D	3.794	25.800	0.999	D	D	0.645	6.417	0.567	5.829	0.996	0.615	0.574	0.659	0.564	.	5.600	4.700	2.055	1.026	0.549	0.968	0.987	0.999	981	.	.	.	ID=COSV63587511;OCCURENCE=1(kidney)	CTNNA2	161	0	512	33	0.0605504587155963	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178571122	178571122	+	G	G	A	Missense_Mutation	SNP	ENST00000591111.5	exon276	c.C70087T	p.R23363C	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon276:c.C70087T:p.R23363C	2q31.2	C3N-00514	.	.	.	.	.	.	.	.	.	9.17	D	.	D	P	.	D	M	T	D	0.541	T	T	T	0.218	0.430	0.301	0.304	T	.	T	T	D	D	3.598	25.000	0.867	D	D	0.620	6.138	0.622	6.507	0.889	0.487	0.546	0.545	0.564	.	5.280	5.280	3.305	1.176	0.676	1.000	0.989	0.998	429	Fibronectin_type_III	.	.	ID=COSV59934151;OCCURENCE=1(NS),1(endometrium)	TTN	144	0	295	22	0.0694006309148265	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178729566	178729566	+	T	T	C	Missense_Mutation	SNP	ENST00000591111.5	exon62	c.A17639G	p.E5880G	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon62:c.A17639G:p.E5880G	2q31.2	C3N-00514	.	.	.	.	.	.	.	.	.	8.16	D	.	D	D	.	D	.	T	D	0.441	T	T	D	0.375	0.398	0.666	0.498	T	.	T	T	T	T	3.753	25.600	0.946	D	D	0.762	8.083	0.767	9.225	1.000	0.554	0.588	0.547	0.564	.	6.060	6.060	6.198	1.138	0.665	1.000	0.990	0.993	343	.	.	.	.	TTN	78	0	287	21	0.0681818181818182	TRUE	TRUE
ENSG00000068024.16	.	BCM	GRCh38.p13	chr2	239236649	239236649	+	C	C	T	Missense_Mutation	SNP	ENST00000345617.7	exon3	c.G38A	p.R13Q	exonic	ENSG00000068024.16	.	nonsynonymous SNV	ENSG00000068024.16:ENST00000345617.7:exon3:c.G38A:p.R13Q	2q37.3	C3N-00514	0.0001	0.0007	0	0	0	0.0001	0	0	rs61754650	6.20	D	T	B	B	N	D	L	T	D	0.429	T	T	D	0.111	.	0.678	0.520	T	T	T	T	T	D	3.330	24.200	0.991	D	N	0.272	3.636	0.341	3.968	1.000	0.615	0.588	0.659	0.568	.	4.680	4.680	4.195	1.026	0.599	1.000	1.000	1.000	922	.	.	.	.	HDAC4	396	0	787	57	0.0675355450236967	TRUE	NA
ENSG00000181555.20	.	BCM	GRCh38.p13	chr3	47122885	47122885	+	T	T	C	Missense_Mutation	SNP	ENST00000409792.3	exon3	c.A1751G	p.Q584R	exonic	ENSG00000181555.20	.	nonsynonymous SNV	ENSG00000181555.20:ENST00000409792.3:exon3:c.A1751G:p.Q584R	3p21.31	C3N-00514	.	.	.	.	.	.	.	.	.	6.20	D	D	B	B	N	N	L	D	D	0.093	T	T	T	0.134	0.035	0.751	0.289	T	T	T	T	D	T	2.482	22.400	0.985	D	N	-0.292	1.633	-0.118	1.997	1.000	0.563	0.654	0.670	0.636	.	5.250	4.080	3.014	0.170	0.665	1.000	0.999	0.999	13	.	.	.	.	SETD2	69	0	147	11	0.069620253164557	TRUE	TRUE
ENSG00000164077.14	.	BCM	GRCh38.p13	chr3	49910837	49910837	+	C	C	T	Missense_Mutation	SNP	ENST00000296473.7	exon4	c.G952A	p.A318T	exonic	ENSG00000164077.14	.	nonsynonymous SNV	ENSG00000164077.14:ENST00000296473.7:exon4:c.G952A:p.A318T	3p21.31	C3N-00514	.	.	.	.	.	.	.	.	.	12.17	D	D	.	.	D	D	M	.	D	0.713	T	T	D	0.241	0.686	0.430	1.100	T	T	D	T	D	D	3.588	25.000	0.999	D	D	0.540	5.366	0.521	5.358	1.000	0.726	0.616	0.594	0.636	.	5.620	5.620	3.211	1.026	0.599	1.000	0.989	0.959	1	.	.	.	ID=COSV56560120;OCCURENCE=1(NS)	MON1A	94	1	246	17	0.064638783269962	TRUE	TRUE
ENSG00000114054.14	.	BCM	GRCh38.p13	chr3	136250400	136250400	+	G	G	A	Missense_Mutation	SNP	ENST00000251654.9	exon1	c.G25A	p.A9T	exonic	ENSG00000114054.14	.	nonsynonymous SNV	ENSG00000114054.14:ENST00000251654.9:exon1:c.G25A:p.A9T	3q22.3	C3N-00514	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	N	N	D	N	0.292	T	D	D	0.401	0.374	0.846	0.097	T	T	D	T	T	T	1.692	16.970	0.950	D	N	-0.951	0.458	-0.870	0.661	1.000	0.442	0.522	0.504	0.373	.	4.980	3.190	2.567	1.176	0.676	0.054	0.005	0.097	346	Acetyl-coenzyme_A_carboxyltransferase,_N-terminal	.	.	.	PCCB	48	0	83	8	0.0879120879120879	TRUE	TRUE
ENSG00000173040.13	.	BCM	GRCh38.p13	chr4	5689333	5689333	+	G	G	A	Missense_Mutation	SNP	ENST00000344408.10	exon5	c.C530T	p.S177L	exonic	ENSG00000173040.13	.	nonsynonymous SNV	ENSG00000173040.13:ENST00000344408.10:exon5:c.C530T:p.S177L	4p16.2	C3N-00514	2.475e-05	0.0002	0	0	0	1.501e-05	0	0	rs145758016	1.20	T	D	B	B	N	N	N	T	N	0.190	T	T	T	0.163	.	0.673	0.020	T	T	T	T	T	T	1.945	18.840	0.966	N	N	-0.891	0.531	-0.795	0.765	0.004	0.615	0.588	0.659	0.636	.	4.540	2.040	1.843	0.179	-0.140	0.991	0.005	0.001	982	.	.	.	ID=COSV60388597;OCCURENCE=1(NS),1(skin),1(lung)	EVC2	289	0	699	40	0.054127198917456	TRUE	TRUE
ENSG00000249693.3	.	BCM	GRCh38.p13	chr4	56531145	56531145	+	C	C	T	Missense_Mutation	SNP	ENST00000512175.3	exon1	c.C469T	p.R157W	exonic	ENSG00000249693.3	.	nonsynonymous SNV	ENSG00000249693.3:ENST00000512175.3:exon1:c.C469T:p.R157W	4q12	C3N-00514	.	.	.	.	.	.	.	.	.	4.12	D	D	.	.	.	.	N	.	D	0.153	.	.	D	.	.	0.444	.	T	T	T	T	.	T	1.084	12.620	0.999	N	N	.	.	.	.	1.000	0.598	0.596	0.608	0.555	.	3.850	1.930	-1.612	0.068	-0.444	0.000	0.007	0.301	704	.	.	.	ID=COSV72866708;OCCURENCE=1(liver)	THEGL	80	1	144	13	0.0828025477707006	TRUE	TRUE
ENSG00000170153.11	.	BCM	GRCh38.p13	chr4	141132550	141132550	+	G	G	T	Missense_Mutation	SNP	ENST00000515673.7	exon1	c.C259A	p.R87S	exonic	ENSG00000170153.11	.	nonsynonymous SNV	ENSG00000170153.11:ENST00000515673.7:exon1:c.C259A:p.R87S	4q31.21	C3N-00514	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	D	0.520	T	T	D	0.120	0.468	0.365	0.708	T	T	T	T	D	T	2.992	23.400	0.987	D	N	-0.309	1.592	-0.158	1.889	1.000	0.437	0.563	0.504	0.604	.	3.930	3.930	2.037	1.175	0.674	1.000	1.000	0.994	902	.	.	.	.	RNF150	256	0	642	47	0.0682148040638607	TRUE	TRUE
ENSG00000056097.16	.	BCM	GRCh38.p13	chr5	32355769	32355771	+	ATC	ATC	-	In_Frame_Del	DEL	ENST00000265069.13	exon20	c.3214_3216del	p.D1072del	exonic	ENSG00000056097.16	.	nonframeshift deletion	ENSG00000056097.16:ENST00000265069.13:exon20:c.3214_3216del:p.D1072del	5p13.3	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFR	84	0	172	12	0.0652173913043478	NA	TRUE
ENSG00000164904.18	.	BCM	GRCh38.p13	chr5	126577176	126577176	+	C	C	T	Missense_Mutation	SNP	ENST00000409134.8	exon6	c.G553A	p.V185I	exonic	ENSG00000164904.18	.	nonsynonymous SNV	ENSG00000164904.18:ENST00000409134.8:exon6:c.G553A:p.V185I	5q23.2	C3N-00514	9.912e-05	0	0.0002	0	0	0.0001	0	6.087e-05	rs61757685	5.20	D	T	B	B	N	D	N	D	N	0.275	T	T	D	0.143	.	0.826	0.122	T	T	T	T	T	T	0.823	9.628	0.965	D	N	-0.691	0.827	-0.606	1.037	0.009	0.707	0.588	0.702	0.714	.	5.200	0.620	2.045	-0.892	-0.173	0.928	0.558	0.165	645	Aldehyde_dehydrogenase_domain	.	.	.	ALDH7A1	495	0	968	81	0.0772163965681602	TRUE	NA
ENSG00000204965.9	.	BCM	GRCh38.p13	chr5	140823378	140823378	+	A	A	T	Missense_Mutation	SNP	ENST00000529859.2	exon1	c.A1603T	p.S535C	exonic	ENSG00000204965.9	.	nonsynonymous SNV	ENSG00000204965.9:ENST00000529859.2:exon1:c.A1603T:p.S535C	5q31.3	C3N-00514	.	.	.	.	.	.	.	.	.	10.18	D	D	D	D	.	D	L	T	D	0.397	T	T	D	0.197	0.426	0.810	0.998	.	T	T	T	D	D	3.662	25.300	0.985	D	N	0.186	3.240	0.067	2.602	0.000	0.554	0.588	0.576	0.542	.	3.860	3.860	0.779	1.280	0.686	0.127	1.000	0.900	28	Cadherin-like	.	.	.	PCDHA5	939	0	2001	149	0.0693023255813953	NA	TRUE
ENSG00000155511.18	.	BCM	GRCh38.p13	chr5	153811145	153811145	+	C	C	T	Missense_Mutation	SNP	ENST00000285900.10	exon16	c.C2641T	p.H881Y	exonic	ENSG00000155511.18	.	nonsynonymous SNV	ENSG00000155511.18:ENST00000285900.10:exon16:c.C2641T:p.H881Y	5q33.2	C3N-00514	.	.	.	.	.	.	.	.	.	6.20	D	T	P	B	D	D	L	T	N	0.562	T	T	T	0.161	0.242	0.421	1.663	T	T	T	T	D	T	2.464	22.300	0.994	D	D	0.355	4.078	0.449	4.723	1.000	0.554	0.574	0.618	0.564	.	5.030	5.030	7.388	1.024	0.599	1.000	0.996	0.995	792	.	.	.	.	GRIA1	416	0	934	68	0.0678642714570858	TRUE	TRUE
ENSG00000221900.6	.	BCM	GRCh38.p13	chr7	53036146	53036146	+	C	C	T	Missense_Mutation	SNP	ENST00000408890.6	exon1	c.C475T	p.R159C	exonic	ENSG00000221900.6	.	nonsynonymous SNV	ENSG00000221900.6:ENST00000408890.6:exon1:c.C475T:p.R159C	7p12.1	C3N-00514	8.927e-06	0	0	0	0	0	0	6.101e-05	rs746175412	1.19	T	T	D	P	.	N	N	T	N	0.083	T	T	T	0.061	0.239	0.132	0.413	T	T	T	T	T	T	1.698	17.020	0.920	N	N	-0.692	0.826	-0.873	0.657	0.000	0.487	0.574	0.547	0.564	.	1.810	0.851	0.327	0.674	0.505	0.000	0.003	0.001	980	.	.	.	ID=COSV68692799;OCCURENCE=1(central_nervous_system),2(lung)	POM121L12	219	0	523	41	0.0726950354609929	TRUE	TRUE
ENSG00000185900.10	.	BCM	GRCh38.p13	chr8	43103612	43103612	+	G	G	T	Missense_Mutation	SNP	ENST00000331373.10	exon4	c.G64T	p.G22W	exonic	ENSG00000185900.10	.	nonsynonymous SNV	ENSG00000185900.10:ENST00000331373.10:exon4:c.G64T:p.G22W	8p11.21	C3N-00514	.	.	.	.	.	.	.	.	.	3.20	D	D	P	B	N	N	L	T	N	0.579	T	T	D	0.298	0.723	0.722	0.344	T	T	T	T	T	T	1.131	13.060	0.977	N	N	-0.583	1.018	-0.702	0.897	1.000	0.707	0.725	0.725	0.636	.	5.160	1.840	-0.194	0.190	-0.276	0.005	0.305	0.132	451	.	.	.	ID=COSV100505838;OCCURENCE=1(skin)	POMK	402	0	747	64	0.0789149198520345	TRUE	TRUE
ENSG00000182022.18	.	BCM	GRCh38.p13	chr10	124046076	124046076	+	C	C	T	Missense_Mutation	SNP	ENST00000435907.6	exon2	c.G137A	p.R46H	exonic	ENSG00000182022.18	.	nonsynonymous SNV	ENSG00000182022.18:ENST00000435907.6:exon2:c.G137A:p.R46H	10q26.13	C3N-00514	0.0001	0.0003	8.637e-05	0	0.0005	7.493e-05	0	0.0001	rs201960331	1.19	T	T	B	B	N	D	N	.	N	0.123	T	T	T	0.010	.	0.150	0.354	T	T	T	T	T	T	1.118	12.940	0.990	N	N	-0.812	0.637	-0.676	0.935	1.000	0.765	0.628	0.659	0.528	.	5.670	2.700	0.727	0.114	-0.313	0.386	0.997	0.985	845	.	.	.	ID=COSV60561060;OCCURENCE=1(oesophagus),1(stomach),1(pancreas)	CHST15	310	0	609	37	0.0572755417956656	TRUE	TRUE
ENSG00000174672.16	.	BCM	GRCh38.p13	chr11	1450644	1450644	+	G	G	C	Missense_Mutation	SNP	ENST00000528841.6	exon14	c.G1345C	p.V449L	exonic	ENSG00000174672.16	.	nonsynonymous SNV	ENSG00000174672.16:ENST00000528841.6:exon14:c.G1345C:p.V449L	11p15.5	C3N-00514	.	.	.	.	.	.	.	.	.	5.20	T	T	P	B	U	D	L	T	N	0.534	T	T	D	0.070	0.228	0.438	0.541	D	T	T	T	D	D	2.675	22.800	0.951	N	N	-0.365	1.462	-0.150	1.910	0.291	0.696	0.588	0.723	0.563	.	4.440	3.450	6.423	1.117	0.608	1.000	0.925	0.829	976	.	.	.	.	BRSK2	93	0	172	28	0.14	TRUE	TRUE
ENSG00000068976.14	.	BCM	GRCh38.p13	chr11	64753902	64753902	+	C	C	T	Missense_Mutation	SNP	ENST00000164139.4	exon10	c.G1216A	p.E406K	exonic	ENSG00000068976.14	.	nonsynonymous SNV	ENSG00000068976.14:ENST00000164139.4:exon10:c.G1216A:p.E406K	11q13.1	C3N-00514	3.188e-05	0	0	0	0	6.567e-05	0	0	rs781394907	14.20	D	T	B	B	D	D	L	D	N	0.869	D	D	D	0.721	0.713	0.930	0.659	T	D	D	D	D	D	2.766	23.000	0.999	D	D	0.204	3.321	0.346	3.996	1.000	0.696	0.588	0.723	0.613	.	4.950	4.950	7.905	1.026	0.599	1.000	0.987	0.986	384	.	.	.	ID=COSV51217665;OCCURENCE=2(liver)	PYGM	431	0	1002	55	0.0520340586565752	TRUE	TRUE
ENSG00000154134.15	.	BCM	GRCh38.p13	chr11	124870261	124870261	+	G	G	A	Missense_Mutation	SNP	ENST00000397801.6	exon5	c.G863A	p.R288H	exonic	ENSG00000154134.15	.	nonsynonymous SNV	ENSG00000154134.15:ENST00000397801.6:exon5:c.G863A:p.R288H	11q24.2	C3N-00514	1.673e-05	0.0002	0	0	0	0	0	0	rs746486301	0.20	T	T	B	B	N	N	N	T	N	0.079	T	T	T	0.059	.	0.342	0.108	T	T	T	T	T	T	0.288	4.154	0.956	N	N	-1.149	0.265	-1.168	0.311	0.001	0.598	0.563	0.596	0.639	.	4.920	-1.360	0.076	-0.105	-0.109	0.000	0.015	0.551	712	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	ROBO3	206	0	519	34	0.0614828209764919	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-00514	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	348	0	657	103	0.135526315789474	TRUE	TRUE
ENSG00000090382.7	.	BCM	GRCh38.p13	chr12	69353181	69353182	+	AG	AG	-	Frame_Shift_Del	DEL	ENST00000261267.7	exon4	c.409_410del	p.D138Cfs*33	exonic	ENSG00000090382.7	.	frameshift deletion	ENSG00000090382.7:ENST00000261267.7:exon4:c.409_410del:p.D138Cfs*33	12q15	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LYZ	401	0	704	58	0.0761154855643045	TRUE	TRUE
ENSG00000196458.11	.	BCM	GRCh38.p13	chr12	132927052	132927052	+	T	T	C	Missense_Mutation	SNP	ENST00000360187.9	exon5	c.A247G	p.I83V	exonic	ENSG00000196458.11	.	nonsynonymous SNV	ENSG00000196458.11:ENST00000360187.9:exon5:c.A247G:p.I83V	12q24.33	C3N-00514	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.067	T	T	T	0.013	0.306	0.364	.	T	T	T	T	T	T	0.273	3.976	0.879	N	N	-1.087	0.318	-1.028	0.454	0.008	0.651	0.588	0.618	0.684	.	3.780	1.450	0.135	0.207	-0.163	0.000	0.681	0.596	958	.	.	.	.	ZNF605	119	0	243	21	0.0795454545454545	TRUE	NA
ENSG00000007545.16	.	BCM	GRCh38.p13	chr16	1626093	1626093	+	G	G	A	Missense_Mutation	SNP	ENST00000397412.8	exon3	c.G467A	p.G156D	exonic	ENSG00000007545.16	.	nonsynonymous SNV	ENSG00000007545.16:ENST00000397412.8:exon3:c.G467A:p.G156D	16p13.3	C3N-00514	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	N	0.424	T	T	T	0.224	0.216	0.134	2.392	T	T	T	T	D	D	4.195	28.600	0.998	D	D	0.756	7.982	0.802	10.196	0.998	0.707	0.654	0.725	0.636	.	5.810	5.810	9.674	1.176	0.676	1.000	0.998	0.998	553	.	.	.	.	CRAMP1	133	0	260	17	0.0613718411552347	TRUE	TRUE
ENSG00000187555.16	.	BCM	GRCh38.p13	chr16	8921242	8921242	+	T	T	C	Missense_Mutation	SNP	ENST00000344836.9	exon4	c.A437G	p.D146G	exonic	ENSG00000187555.16	.	nonsynonymous SNV	ENSG00000187555.16:ENST00000344836.9:exon4:c.A437G:p.D146G	16p13.2	C3N-00514	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	N	T	N	0.492	T	T	T	0.213	0.568	0.763	1.880	T	T	T	T	D	D	2.272	21.400	0.991	D	D	-0.262	1.710	0.031	2.468	1.000	0.722	0.699	0.725	0.711	.	5.900	5.900	7.824	1.138	0.665	1.000	0.999	0.997	851	MATH/TRAF_domain	.	.	.	USP7	126	0	275	16	0.0549828178694158	TRUE	TRUE
ENSG00000140853.15	.	BCM	GRCh38.p13	chr16	57026438	57026438	+	G	G	A	Missense_Mutation	SNP	ENST00000262510.10	exon6	c.G1495A	p.V499I	exonic	ENSG00000140853.15	.	nonsynonymous SNV	ENSG00000140853.15:ENST00000262510.10:exon6:c.G1495A:p.V499I	16q13	C3N-00514	0.0002	0.0003	0.0002	0.0001	0	0.0002	0	0.0002	rs61744164	2.20	T	T	B	B	N	N	N	D	N	0.037	T	T	D	0.147	.	0.218	0.204	T	T	T	T	T	T	-1.253	0.002	0.415	N	N	-1.975	0.010	-1.984	0.015	1.000	0.672	0.702	0.602	0.592	.	5.400	-5.690	-0.075	-2.201	-1.554	0.001	0.000	0.001	917	.	.	.	ID=COSV52658084;OCCURENCE=1(large_intestine)	NLRC5	400	0	876	70	0.0739957716701903	TRUE	TRUE
ENSG00000108576.10	.	BCM	GRCh38.p13	chr17	30210595	30210595	+	C	C	T	Missense_Mutation	SNP	ENST00000650711.1	exon11	c.G1369A	p.V457I	exonic	ENSG00000108576.10	.	nonsynonymous SNV	ENSG00000108576.10:ENST00000650711.1:exon11:c.G1369A:p.V457I	17q11.2	C3N-00514	6.611e-05	0	0	0	0	1.504e-05	0	0.0004	rs190758123	0.20	T	T	B	B	N	N	N	T	N	0.122	T	T	T	0.088	.	0.227	0.354	T	T	T	T	T	T	0.064	1.784	0.840	N	N	-1.066	0.338	-0.897	0.624	0.036	0.644	0.688	0.574	0.542	.	6.040	2.640	-1.138	0.207	-0.108	0.000	0.976	0.988	615	.	.	.	ID=COSV55565955;OCCURENCE=2(central_nervous_system),2(haematopoietic_and_lymphoid_tissue),1(pancreas),1(skin),1(endometrium)	SLC6A4	183	0	366	35	0.0872817955112219	TRUE	TRUE
ENSG00000064687.13	.	BCM	GRCh38.p13	chr19	1046252	1046252	+	G	G	A	Missense_Mutation	SNP	ENST00000263094.11	exon13	c.G1468A	p.A490T	exonic	ENSG00000064687.13	.	nonsynonymous SNV	ENSG00000064687.13:ENST00000263094.11:exon13:c.G1468A:p.A490T	19p13.3	C3N-00514	.	.	.	.	.	.	.	.	.	15.19	T	T	D	D	.	D	M	D	D	0.561	D	D	D	0.594	0.274	0.950	0.491	T	T	D	D	D	D	3.747	25.600	0.999	D	D	0.537	5.338	0.459	4.802	1.000	0.660	0.654	0.696	0.605	.	4.950	4.950	9.782	1.003	0.583	1.000	0.008	0.015	988	.	.	.	ID=COSV54025106;OCCURENCE=1(large_intestine),1(pleura)	ABCA7	251	0	485	27	0.052734375	TRUE	TRUE
ENSG00000185800.12	.	BCM	GRCh38.p13	chr19	45785921	45785921	+	C	C	T	Missense_Mutation	SNP	ENST00000593999.1	exon1	c.G53A	p.R18H	exonic	ENSG00000185800.12;ENSG00000268434.5	.	nonsynonymous SNV	ENSG00000268434.5:ENST00000593999.1:exon1:c.G53A:p.R18H	19q13.32	C3N-00514	2.766e-05	0	0	0	0	0	0	0.0002	rs778487763	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DMWD	165	0	209	20	0.0873362445414847	TRUE	NA
ENSG00000142515.15	.	BCM	GRCh38.p13	chr19	50858220	50858220	+	C	C	T	Missense_Mutation	SNP	ENST00000326003.7	exon3	c.C398T	p.T133M	exonic	ENSG00000142515.15	.	nonsynonymous SNV	ENSG00000142515.15:ENST00000326003.7:exon3:c.C398T:p.T133M	19q13.33	C3N-00514	1.649e-05	0	0	0	0	2.999e-05	0	0	rs373661565	7.18	D	D	.	.	N	N	M	T	D	0.489	T	T	T	0.102	.	0.744	0.450	T	D	T	T	D	D	2.233	21.100	0.997	N	N	-0.027	2.416	-0.319	1.525	0.021	0.487	0.574	0.492	0.564	.	2.310	2.310	0.492	0.888	0.581	0.001	0.009	0.012	851	Serine_proteases,_trypsin_domain	.	.	ID=COSV58101547;OCCURENCE=3(large_intestine),1(stomach),1(haematopoietic_and_lymphoid_tissue)	KLK3	252	1	561	43	0.0711920529801325	TRUE	TRUE
ENSG00000173638.19	.	BCM	GRCh38.p13	chr21	45516043	45516043	+	G	G	A	Missense_Mutation	SNP	ENST00000311124.9	exon6	c.C1391T	p.P464L	exonic	ENSG00000173638.19	.	nonsynonymous SNV	ENSG00000173638.19:ENST00000311124.9:exon6:c.C1391T:p.P464L	21q22.3	C3N-00514	.	.	.	.	.	.	.	.	rs749244983	2.20	D	T	P	B	N	D	N	T	N	0.097	T	T	T	0.066	0.337	0.173	0.118	T	T	T	T	T	T	-0.051	1.046	0.858	N	N	-1.613	0.052	-1.720	0.047	0.995	0.672	0.702	0.607	0.636	.	4.560	-5.770	-0.029	-3.287	-3.079	0.001	0.000	0.000	580	.	.	.	.	SLC19A1	143	1	305	24	0.0729483282674772	TRUE	NA
ENSG00000068323.17	.	BCM	GRCh38.p13	chrX	49039331	49039331	+	G	G	A	Missense_Mutation	SNP	ENST00000315869.8	exon3	c.C310T	p.P104S	exonic	ENSG00000068323.17	.	nonsynonymous SNV	ENSG00000068323.17:ENST00000315869.8:exon3:c.C310T:p.P104S	Xp11.23	C3N-00514	.	.	.	.	.	.	.	.	.	5.19	T	T	B	B	N	D	L	T	D	0.108	T	T	T	0.070	0.340	0.200	0.923	T	D	T	T	D	T	2.137	20.400	0.997	D	.	.	.	.	.	1.000	.	.	.	.	.	5.030	3.930	2.951	1.176	0.676	1.000	1.000	0.999	36	.	.	.	.	TFE3	92	0	176	33	0.157894736842105	TRUE	TRUE
ENSG00000198793.13	.	BCM	GRCh38.p13	chr1	11259386	11259386	+	G	G	A	Silent	SNP	ENST00000361445.9	exon2	c.C24T	p.A8A	exonic	ENSG00000198793.13	.	synonymous SNV	ENSG00000198793.13:ENST00000361445.9:exon2:c.C24T:p.A8A	1p36.22	C3N-00514	8.601e-06	0	0	0	0	1.53e-05	0	0	rs779391809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63868114;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(skin)	MTOR	125	0	237	21	0.0813953488372093	TRUE	TRUE
ENSG00000159189.12	.	BCM	GRCh38.p13	chr1	22647687	22647687	+	C	C	T	Silent	SNP	ENST00000374640.9	exon3	c.C642T	p.G214G	exonic	ENSG00000159189.12	.	synonymous SNV	ENSG00000159189.12:ENST00000374640.9:exon3:c.C642T:p.G214G	1p36.12	C3N-00514	1.655e-05	0	0	0	0	3.013e-05	0	0	rs778815928	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV104687323;OCCURENCE=1(skin)	C1QC	187	0	421	41	0.0887445887445888	TRUE	NA
ENSG00000154358.21	.	BCM	GRCh38.p13	chr1	228339969	228339969	+	C	C	T	Silent	SNP	ENST00000422127.5	exon70	c.C17283T	p.C5761C	exonic	ENSG00000154358.21	.	synonymous SNV	ENSG00000154358.21:ENST00000422127.5:exon70:c.C17283T:p.C5761C	1q42.13	C3N-00514	8.302e-06	0	0	0	0.0002	0	0	0	rs752645262	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OBSCN	719	1	1408	119	0.0779305828421742	TRUE	NA
ENSG00000176887.7	.	BCM	GRCh38.p13	chr2	5693252	5693252	+	C	C	T	Silent	SNP	ENST00000322002.5	exon1	c.C531T	p.G177G	exonic	ENSG00000176887.7	.	synonymous SNV	ENSG00000176887.7:ENST00000322002.5:exon1:c.C531T:p.G177G	2p25.2	C3N-00514	.	.	.	.	.	.	.	.	rs373041001	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100430678;OCCURENCE=1(stomach)	SOX11	33	0	168	21	0.111111111111111	TRUE	NA
ENSG00000136068.15	.	BCM	GRCh38.p13	chr3	58145991	58145991	+	G	G	A	Silent	SNP	ENST00000295956.9	exon33	c.G5496A	p.V1832V	exonic	ENSG00000136068.15	.	synonymous SNV	ENSG00000136068.15:ENST00000295956.9:exon33:c.G5496A:p.V1832V	3p14.3	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FLNB	509	0	938	90	0.0875486381322957	TRUE	TRUE
ENSG00000188848.16	.	BCM	GRCh38.p13	chr4	42143855	42143855	+	G	G	A	Silent	SNP	ENST00000502486.6	exon3	c.C627T	p.N209N	exonic	ENSG00000188848.16	.	synonymous SNV	ENSG00000188848.16:ENST00000502486.6:exon3:c.C627T:p.N209N	4p13	C3N-00514	1.882e-05	0.0001	0	0	0	0	0	0.0001	rs574971489	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV72468915;OCCURENCE=1(large_intestine),2(upper_aerodigestive_tract),1(endometrium)	BEND4	40	0	98	13	0.117117117117117	TRUE	TRUE
ENSG00000170561.13	.	BCM	GRCh38.p13	chr5	2749039	2749039	+	G	G	A	Silent	SNP	ENST00000302057.6	exon3	c.C669T	p.H223H	exonic	ENSG00000170561.13	.	synonymous SNV	ENSG00000170561.13:ENST00000302057.6:exon3:c.C669T:p.H223H	5p15.33	C3N-00514	9.833e-06	0	9.638e-05	0	0	0	0	0	rs753207229	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IRX2	483	0	902	71	0.0729701952723535	TRUE	NA
ENSG00000113262.16	.	BCM	GRCh38.p13	chr5	178994537	178994537	+	C	C	T	Silent	SNP	ENST00000517717.3	exon2	c.G408A	p.P136P	exonic	ENSG00000113262.16	.	synonymous SNV	ENSG00000113262.16:ENST00000517717.3:exon2:c.G408A:p.P136P	5q35.3	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51445887;OCCURENCE=1(large_intestine)	GRM6	87	0	214	21	0.0893617021276596	TRUE	TRUE
ENSG00000095321.17	.	BCM	GRCh38.p13	chr9	129104283	129104283	+	G	G	A	Silent	SNP	ENST00000318080.7	exon3	c.C315T	p.T105T	exonic	ENSG00000095321.17	.	synonymous SNV	ENSG00000095321.17:ENST00000318080.7:exon3:c.C315T:p.T105T	9q34.11	C3N-00514	.	.	.	.	.	.	.	.	rs959328458	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CRAT	213	1	382	28	0.0682926829268293	TRUE	NA
ENSG00000130635.16	.	BCM	GRCh38.p13	chr9	134730424	134730424	+	C	C	T	Silent	SNP	ENST00000371817.8	exon7	c.C1113T	p.G371G	exonic	ENSG00000130635.16	.	synonymous SNV	ENSG00000130635.16:ENST00000371817.8:exon7:c.C1113T:p.G371G	9q34.3	C3N-00514	3.312e-05	0	8.657e-05	0	0	4.528e-05	0	0	rs754423580	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL5A1	517	0	973	82	0.0777251184834123	TRUE	NA
ENSG00000184937.15	.	BCM	GRCh38.p13	chr11	32400008	32400008	+	C	C	T	Silent	SNP	ENST00000452863.9	exon6	c.G1053A	p.T351T	exonic	ENSG00000184937.15	.	synonymous SNV	ENSG00000184937.15:ENST00000452863.9:exon6:c.G1053A:p.T351T	11p13	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WT1	608	0	1256	81	0.0605833956619297	TRUE	NA
ENSG00000139292.13	.	BCM	GRCh38.p13	chr12	71584512	71584512	+	G	G	A	Silent	SNP	ENST00000266674.10	exon18	c.G2502A	p.L834L	exonic	ENSG00000139292.13	.	synonymous SNV	ENSG00000139292.13:ENST00000266674.10:exon18:c.G2502A:p.L834L	12q21.1	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LGR5	150	0	371	27	0.0678391959798995	TRUE	TRUE
ENSG00000022840.16	.	BCM	GRCh38.p13	chr12	120563934	120563934	+	C	C	T	Silent	SNP	ENST00000325954.9	exon10	c.C1656T	p.S552S	exonic	ENSG00000022840.16	.	synonymous SNV	ENSG00000022840.16:ENST00000325954.9:exon10:c.C1656T:p.S552S	12q24.31	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF10	188	0	379	26	0.0641975308641975	TRUE	TRUE
ENSG00000176349.11	.	BCM	GRCh38.p13	chr7	1847764	1847764	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000176349.11	.	.	.	7p22.3	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC104129.1	91	0	319	26	0.0753623188405797	TRUE	NA
ENSG00000165802.23	.	BCM	GRCh38.p13	chr9	137452642	137452642	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000165802.23	.	.	.	9q34.3	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NSMF	351	0	761	68	0.0820265379975875	TRUE	NA
ENSG00000099246.17	.	BCM	GRCh38.p13	chr10	27542080	27542080	+	C	C	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000099246.17	ENST00000356940.11:c.*4029C>A	.	.	10p12.1	C3N-00514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAB18	405	1	784	61	0.072189349112426	TRUE	NA
ENSG00000168175.15	.	BCM	GRCh38.p13	chr14	55051674	55051674	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000168175.15	ENST00000395468.9:c.-10010C>T	.	.	14q22.3	C3N-00514	2.14e-05	0	0.0001	0	0	1.965e-05	0	0	rs767344249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAPK1IP1L	259	0	817	66	0.0747451868629672	TRUE	NA
ENSG00000134684.10	.	BCM	GRCh38.p13	chr1	32806551	32806551	+	C	C	G	Missense_Mutation	SNP	ENST00000373477.8	exon4	c.G441C	p.K147N	exonic	ENSG00000134684.10	.	nonsynonymous SNV	ENSG00000134684.10:ENST00000373477.8:exon4:c.G441C:p.K147N	1p35.1	C3L-02897	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.750	D	D	D	0.509	0.475	0.843	1.206	D	T	T	T	D	D	2.346	21.800	0.996	D	N	0.103	2.898	-0.077	2.113	0.419	0.707	0.702	0.698	0.714	.	4.820	-1.670	0.219	0.179	-0.181	0.989	0.998	0.976	281	.	.	.	.	YARS1	423	0	315	29	0.0843023255813953	TRUE	TRUE
ENSG00000159450.12	.	BCM	GRCh38.p13	chr1	152109384	152109384	+	T	T	C	Missense_Mutation	SNP	ENST00000614923.1	exon3	c.A3833G	p.D1278G	exonic	ENSG00000159450.12	.	nonsynonymous SNV	ENSG00000159450.12:ENST00000614923.1:exon3:c.A3833G:p.D1278G	1q21.3	C3L-02897	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.068	T	T	T	0.008	0.235	0.188	0.346	T	T	T	T	T	T	1.260	14.100	0.791	N	N	-2.031	0.008	-2.106	0.008	1.000	0.765	0.627	0.732	0.527	.	1.160	-2.110	0.576	-0.596	-0.210	0.002	0.000	0.004	478	.	.	.	.	TCHH	280	0	202	40	0.165289256198347	TRUE	TRUE
ENSG00000153201.16	.	BCM	GRCh38.p13	chr2	108730872	108730872	+	T	T	G	Missense_Mutation	SNP	ENST00000283195.11	exon3	c.T239G	p.V80G	exonic	ENSG00000153201.16	.	nonsynonymous SNV	ENSG00000153201.16:ENST00000283195.11:exon3:c.T239G:p.V80G	2q13	C3L-02897	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	.	D	L	T	D	0.462	T	T	D	0.624	0.731	0.816	0.595	T	D	D	D	D	T	4.127	28.000	0.995	D	D	0.620	6.130	0.563	5.784	0.980	0.732	0.710	0.651	0.728	.	4.240	4.240	7.181	1.125	0.588	1.000	0.880	0.855	887	Tetratricopeptide_repeat-containing_domain	.	.	.	RANBP2	476	0	330	28	0.0782122905027933	NA	TRUE
ENSG00000135898.10	.	BCM	GRCh38.p13	chr2	230910943	230910943	+	C	C	T	Missense_Mutation	SNP	ENST00000650999.1	exon2	c.G20A	p.S7N	exonic	ENSG00000135898.10	.	nonsynonymous SNV	ENSG00000135898.10:ENST00000650999.1:exon2:c.G20A:p.S7N	2q37.1	C3L-02897	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.042	T	T	T	0.042	0.166	0.352	0.247	T	T	T	T	T	T	0.119	2.270	0.964	N	N	-0.741	0.744	-0.769	0.802	1.000	0.632	0.698	0.547	0.542	.	4.680	2.740	-0.380	1.026	0.549	0.000	0.001	0.087	809	.	.	.	.	GPR55	73	0	61	9	0.128571428571429	TRUE	TRUE
ENSG00000162804.14	.	BCM	GRCh38.p13	chr2	241081781	241081781	+	C	C	T	Missense_Mutation	SNP	ENST00000310397.13	exon28	c.C4021T	p.R1341C	exonic	ENSG00000162804.14	.	nonsynonymous SNV	ENSG00000162804.14:ENST00000310397.13:exon28:c.C4021T:p.R1341C	2q37.3	C3L-02897	4.268e-05	0	0	0	0	8.22e-05	0	0	rs749096541	13.20	D	D	D	P	N	D	M	D	D	0.480	D	D	D	0.581	.	0.908	1.334	T	T	T	T	D	D	4.086	27.600	0.999	D	N	0.400	4.342	0.354	4.047	1.000	0.660	0.514	0.576	0.592	.	4.330	3.440	1.138	1.026	0.599	0.953	0.991	0.896	982	EGF-like,_conserved_site;EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	SNED1	179	0	113	6	0.0504201680672269	TRUE	NA
ENSG00000153802.12	.	BCM	GRCh38.p13	chr4	67822459	67822459	+	G	G	A	Missense_Mutation	SNP	ENST00000283916.11	exon10	c.C1135T	p.R379W	exonic	ENSG00000153802.12	.	nonsynonymous SNV	ENSG00000153802.12:ENST00000283916.11:exon10:c.C1135T:p.R379W	4q13.2	C3L-02897	1.653e-05	0	0	0	0.0002	0	0	6.064e-05	rs758167149	9.20	D	D	D	D	N	N	M	T	D	0.331	T	T	D	0.276	0.598	0.691	0.462	T	D	T	T	D	T	3.128	23.700	0.998	N	N	-0.288	1.645	-0.401	1.371	0.000	0.487	0.574	0.574	0.564	.	5.780	4.010	0.356	0.195	-0.153	0.000	0.982	0.963	878	Serine_proteases,_trypsin_domain	.	.	ID=COSV52224233;OCCURENCE=1(pancreas)	TMPRSS11D	221	0	140	14	0.0909090909090909	TRUE	TRUE
ENSG00000196159.12	.	BCM	GRCh38.p13	chr4	125316839	125316839	+	C	C	A	Missense_Mutation	SNP	ENST00000674496.1	exon1	c.C428A	p.T143N	exonic	ENSG00000196159.12	.	nonsynonymous SNV	ENSG00000196159.12:ENST00000674496.1:exon1:c.C428A:p.T143N	4q28.1	C3L-02897	.	.	.	.	.	.	.	.	.	7.20	D	D	P	P	U	D	N	T	N	0.309	T	T	T	0.115	0.419	0.155	0.254	T	T	T	T	D	D	3.532	24.800	0.986	D	D	0.269	3.625	0.299	3.714	1.000	0.447	0.563	0.504	0.581	.	5.200	4.350	6.001	1.026	0.599	1.000	0.987	0.900	932	Cadherin-like	.	.	.	FAT4	426	0	278	43	0.133956386292835	TRUE	TRUE
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	169714387	169714387	+	G	G	A	Missense_Mutation	SNP	ENST00000520908.7	exon19	c.G1871A	p.R624H	exonic	ENSG00000134516.18	.	nonsynonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon19:c.G1871A:p.R624H	5q35.1	C3L-02897	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.647	T	T	T	0.351	0.434	0.598	1.143	T	T	T	T	D	D	4.085	27.600	0.999	D	D	0.838	9.560	0.790	9.839	1.000	0.672	0.702	0.653	0.568	.	5.790	4.920	10.003	1.176	0.676	1.000	1.000	1.000	952	.	.	.	ID=COSV56943483;OCCURENCE=1(breast),2(liver)	DOCK2	221	0	169	15	0.0815217391304348	TRUE	TRUE
ENSG00000204394.13	.	BCM	GRCh38.p13	chr6	31785604	31785604	+	C	C	A	Missense_Mutation	SNP	ENST00000375663.8	exon9	c.G1230T	p.E410D	exonic	ENSG00000204394.13	.	nonsynonymous SNV	ENSG00000204394.13:ENST00000375663.8:exon9:c.G1230T:p.E410D	6p21.33	C3L-02897	.	.	.	.	.	.	.	.	.	4.19	T	T	B	B	D	D	L	T	N	0.210	T	T	T	0.112	0.704	0.222	0.460	T	T	T	T	D	.	1.383	14.970	0.994	D	N	-0.180	1.934	-0.100	2.046	1.000	0.707	0.702	0.698	0.714	.	5.290	4.430	0.520	-0.243	-0.182	0.998	0.199	0.679	900	Aminoacyl-tRNA_synthetase,_class_Ia	.	.	.	VARS1	196	0	126	7	0.0526315789473684	TRUE	TRUE
ENSG00000105877.18	.	BCM	GRCh38.p13	chr7	21687148	21687148	+	C	C	T	Missense_Mutation	SNP	ENST00000409508.8	exon33	c.C5671T	p.P1891S	exonic	ENSG00000105877.18	.	nonsynonymous SNV	ENSG00000105877.18:ENST00000409508.8:exon33:c.C5671T:p.P1891S	7p15.3	C3L-02897	0.0005	0.0001	9.441e-05	0	0	0.0008	0.0012	0	rs201704416	8.16	D	.	.	.	D	D	.	T	D	0.787	T	T	D	0.195	.	0.398	.	T	T	T	T	T	D	3.489	24.700	0.999	D	D	0.696	7.069	0.715	8.041	0.482	0.554	0.574	0.618	0.564	.	5.840	5.840	4.974	1.025	0.599	1.000	0.949	0.959	803	Dynein_heavy_chain,_hydrolytic_ATP-binding_dynein_motor_region_D1;AAA+_ATPase_domain	.	.	.	DNAH11	164	0	106	12	0.101694915254237	TRUE	NA
ENSG00000127947.16	.	BCM	GRCh38.p13	chr7	77627210	77627210	+	C	C	T	Missense_Mutation	SNP	ENST00000248594.11	exon13	c.C1531T	p.P511S	exonic	ENSG00000127947.16	.	nonsynonymous SNV	ENSG00000127947.16:ENST00000248594.11:exon13:c.C1531T:p.P511S	7q11.23	C3L-02897	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.039	T	T	T	0.058	0.066	0.204	0.024	T	T	T	T	T	T	0.710	8.550	0.582	N	N	-1.171	0.248	-1.120	0.355	0.648	0.707	0.725	0.702	0.711	.	5.930	-0.384	0.436	-0.727	-0.202	0.015	0.225	0.993	906	.	.	.	.	PTPN12	138	0	81	11	0.119565217391304	TRUE	TRUE
ENSG00000105967.16	.	BCM	GRCh38.p13	chr7	115974171	115974171	+	G	G	T	Missense_Mutation	SNP	ENST00000265440.12	exon3	c.C266A	p.T89K	exonic	ENSG00000105967.16	.	nonsynonymous SNV	ENSG00000105967.16:ENST00000265440.12:exon3:c.C266A:p.T89K	7q31.2	C3L-02897	.	.	.	.	.	.	.	.	.	8.20	D	D	B	B	N	D	M	T	D	0.731	T	T	T	0.175	0.557	0.466	0.046	T	T	T	T	D	T	3.066	23.600	0.962	D	D	0.128	2.998	0.248	3.430	1.000	0.693	0.588	0.574	0.564	.	4.770	4.770	4.720	1.155	0.674	1.000	1.000	0.997	730	.	.	.	.	TFEC	116	0	70	9	0.113924050632911	TRUE	TRUE
ENSG00000104321.11	.	BCM	GRCh38.p13	chr8	72039778	72039778	+	C	C	T	Missense_Mutation	SNP	ENST00000262209.5	exon18	c.G2081A	p.R694H	exonic	ENSG00000104321.11	.	nonsynonymous SNV	ENSG00000104321.11:ENST00000262209.5:exon18:c.G2081A:p.R694H	8q21.11	C3L-02897	1.662e-05	0	0	0	0	3.025e-05	0	0	rs772226867	17.20	D	D	D	D	D	D	M	T	D	0.723	D	D	D	0.622	0.786	0.863	0.570	T	D	D	T	D	D	4.329	29.800	0.999	D	D	0.711	7.269	0.682	7.425	0.999	0.554	0.588	0.574	0.564	.	5.220	5.220	6.090	1.026	0.549	1.000	1.000	0.999	887	.	.	.	ID=COSV51560119;OCCURENCE=1(large_intestine)	TRPA1	258	0	172	19	0.0994764397905759	TRUE	TRUE
ENSG00000147724.12	.	BCM	GRCh38.p13	chr8	138151692	138151692	+	C	C	T	Missense_Mutation	SNP	ENST00000395297.6	exon13	c.G2783A	p.G928D	exonic	ENSG00000147724.12	.	nonsynonymous SNV	ENSG00000147724.12:ENST00000395297.6:exon13:c.G2783A:p.G928D	8q24.23	C3L-02897	2.472e-05	0	0.0002	0	0	1.499e-05	0	0	rs755060753	0.20	T	T	B	B	N	N	N	T	N	0.111	T	T	T	0.040	0.072	0.043	0.081	T	T	T	T	T	T	-0.372	0.220	0.169	N	N	-1.157	0.259	-1.176	0.303	0.000	0.487	0.574	0.574	0.564	.	5.450	-2.490	-1.233	-0.727	0.599	0.000	0.000	0.380	955	.	.	.	.	FAM135B	356	0	251	27	0.0971223021582734	TRUE	NA
ENSG00000226807.6	.	BCM	GRCh38.p13	chr8	141477445	141477445	+	G	G	A	Missense_Mutation	SNP	ENST00000621837.1	exon12	c.C1403T	p.T468M	exonic	ENSG00000226807.6	.	nonsynonymous SNV	ENSG00000226807.6:ENST00000621837.1:exon12:c.C1403T:p.T468M	8q24.3	C3L-02897	0.0006	0.0002	0.0013	0.0005	0	0.0008	0	6.095e-05	rs202047417	1.6	.	.	.	.	.	.	.	.	.	0.400	.	.	.	.	.	0.061	.	T	.	T	T	.	T	3.272	24.000	0.999	D	N	.	.	.	.	0.654	0.487	0.574	0.547	0.613	.	4.360	4.360	5.061	1.082	0.500	0.770	0.018	0.134	894	.	.	.	ID=COSV101435963;OCCURENCE=1(stomach)	MROH5	274	1	220	22	0.0909090909090909	TRUE	NA
ENSG00000107864.15	.	BCM	GRCh38.p13	chr10	92052382	92052382	+	G	G	A	Missense_Mutation	SNP	ENST00000265997.5	exon10	c.C1927T	p.R643C	exonic	ENSG00000107864.15	.	nonsynonymous SNV	ENSG00000107864.15:ENST00000265997.5:exon10:c.C1927T:p.R643C	10q23.32	C3L-02897	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.661	T	T	T	0.512	0.541	0.871	2.832	D	T	D	D	D	D	4.475	32	0.999	D	D	0.947	12.332	0.939	15.536	1.000	0.651	0.709	0.659	0.655	.	5.810	5.810	10.003	1.176	0.676	1.000	0.979	0.994	927	Cytoplasmic_polyadenylation_element-binding_protein,_ZZ_domain	.	.	.	CPEB3	307	0	178	21	0.105527638190955	TRUE	NA
ENSG00000166272.18	.	BCM	GRCh38.p13	chr10	102813295	102813295	+	C	C	A	Missense_Mutation	SNP	ENST00000369889.5	exon4	c.C993A	p.D331E	exonic	ENSG00000166272.18	.	nonsynonymous SNV	ENSG00000166272.18:ENST00000369889.5:exon4:c.C993A:p.D331E	10q24.32	C3L-02897	.	.	.	.	.	.	.	.	.	7.20	T	T	D	D	D	D	M	T	N	0.318	T	T	T	0.222	0.094	0.082	0.907	T	T	T	T	D	T	2.690	22.800	0.997	D	N	0.649	6.463	0.672	7.256	1.000	0.722	0.725	0.710	0.735	.	5.940	5.940	1.713	1.026	0.599	1.000	0.886	0.058	572	.	.	.	.	WBP1L	142	0	100	17	0.145299145299145	TRUE	TRUE
ENSG00000151651.16	.	BCM	GRCh38.p13	chr10	133273282	133273282	+	G	G	A	Missense_Mutation	SNP	ENST00000445355.8	exon6	c.C545T	p.T182M	exonic	ENSG00000151651.16	.	nonsynonymous SNV	ENSG00000151651.16:ENST00000445355.8:exon6:c.C545T:p.T182M	10q26.3	C3L-02897	0.0001	0.0003	0	0.0005	0	6.822e-05	0	8.933e-05	rs746594474	0.16	T	T	P	B	.	N	N	T	N	0.173	.	.	T	.	.	0.732	0.154	T	T	T	T	.	T	-0.299	0.313	0.889	N	N	.	.	.	.	1.000	0.672	0.702	0.645	0.563	.	4.380	-2.480	-0.653	-1.042	-0.968	0.000	0.000	0.000	994	.	.	.	.	ADAM8	388	1	307	34	0.0997067448680352	TRUE	NA
ENSG00000180988.2	.	BCM	GRCh38.p13	chr11	5820835	5820835	+	G	G	A	Missense_Mutation	SNP	ENST00000317037.2	exon1	c.G500A	p.R167H	exonic	ENSG00000180988.2	.	nonsynonymous SNV	ENSG00000180988.2:ENST00000317037.2:exon1:c.G500A:p.R167H	11p15.4	C3L-02897	0.0002	0	8.652e-05	0	0	0	0	0.0014	rs551878101	4.20	D	T	B	B	N	N	M	T	D	0.129	T	T	T	0.079	0.493	0.422	0.082	T	T	T	T	T	D	1.519	15.860	0.997	N	N	-0.303	1.607	-0.249	1.672	0.010	0.554	0.588	0.574	0.564	.	6.110	3.190	0.039	-0.149	-0.121	0.000	0.000	0.875	676	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV57676973;OCCURENCE=1(liver),1(large_intestine),1(stomach)	OR52N2	143	0	88	14	0.137254901960784	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02897	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	333	0	198	28	0.123893805309735	TRUE	TRUE
ENSG00000125304.10	.	BCM	GRCh38.p13	chr13	99541599	99541599	+	A	A	T	Missense_Mutation	SNP	ENST00000376387.5	exon9	c.A949T	p.M317L	exonic	ENSG00000125304.10	.	nonsynonymous SNV	ENSG00000125304.10:ENST00000376387.5:exon9:c.A949T:p.M317L	13q32.3	C3L-02897	.	.	.	.	.	.	.	.	.	9.20	T	T	B	B	D	D	L	T	N	0.699	T	T	T	0.266	0.633	0.672	0.705	D	T	D	D	D	D	2.696	22.800	0.969	D	D	0.081	2.812	0.267	3.533	1.000	0.722	0.699	0.725	0.734	.	5.240	5.240	9.156	1.312	0.691	1.000	1.000	0.997	449	.	.	.	.	TM9SF2	161	0	100	10	0.0909090909090909	TRUE	TRUE
ENSG00000104064.17	.	BCM	GRCh38.p13	chr15	50304075	50304075	+	A	A	G	Missense_Mutation	SNP	ENST00000220429.12	exon3	c.T167C	p.V56A	exonic	ENSG00000104064.17	.	nonsynonymous SNV	ENSG00000104064.17:ENST00000220429.12:exon3:c.T167C:p.V56A	15q21.2	C3L-02897	.	.	.	.	.	.	.	.	.	14.20	D	T	D	D	D	D	L	T	D	0.689	T	T	D	0.371	0.590	0.699	3.141	D	T	D	D	D	D	4.071	27.500	0.998	D	D	0.557	5.510	0.613	6.389	1.000	0.706	0.710	0.725	0.714	.	5.450	5.450	9.325	1.288	0.756	1.000	0.959	0.984	701	Ankyrin_repeat-containing_domain	.	.	.	GABPB1	219	0	175	10	0.0540540540540541	TRUE	TRUE
ENSG00000140465.14	.	BCM	GRCh38.p13	chr15	74720599	74720599	+	G	G	A	Missense_Mutation	SNP	ENST00000379727.8	exon7	c.C1429T	p.R477W	exonic	ENSG00000140465.14	.	nonsynonymous SNV	ENSG00000140465.14:ENST00000379727.8:exon7:c.C1429T:p.R477W	15q24.1	C3L-02897	0.0003	0.0020	0	0	0.0002	4.507e-05	0.0011	0.0003	rs56240201	10.20	D	D	D	P	N	N	M	T	D	0.306	T	D	D	0.270	.	0.965	0.189	T	D	T	T	T	T	3.103	23.600	0.999	D	D	0.415	4.439	0.238	3.374	0.045	0.554	0.588	0.602	0.621	.	5.650	4.700	2.408	1.159	0.672	0.994	0.515	0.071	499	.	.	.	ID=COSV65697213;OCCURENCE=1(breast),1(biliary_tract),1(stomach),1(skin)	CYP1A1	133	0	94	8	0.0784313725490196	NA	TRUE
ENSG00000196155.13	.	BCM	GRCh38.p13	chr16	67284347	67284347	+	G	G	T	Missense_Mutation	SNP	ENST00000379344.8	exon12	c.G1582T	p.G528W	exonic	ENSG00000196155.13	.	nonsynonymous SNV	ENSG00000196155.13:ENST00000379344.8:exon12:c.G1582T:p.G528W	16q22.1	C3L-02897	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	.	D	M	T	N	0.677	T	T	D	0.202	0.422	0.364	1.004	T	T	T	T	D	T	3.597	25.000	0.991	D	N	0.357	4.086	0.204	3.202	1.000	0.696	0.852	0.645	0.563	.	4.330	4.330	6.353	1.176	0.618	1.000	0.010	0.082	23	.	.	.	.	PLEKHG4	358	0	252	30	0.106382978723404	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673806	7673806	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G814A	p.V272M	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G814A:p.V272M	17p13.1	C3L-02897	2.683e-05	0	9.992e-05	0	0	3.229e-05	0	0	rs121912657	17.20	D	D	D	D	D	D	M	D	N	0.733	D	D	D	0.907	0.868	0.965	0.387	T	D	D	D	D	T	3.966	26.700	0.999	D	D	0.829	9.378	0.756	8.946	1.000	0.722	0.702	0.725	0.735	.	5.130	5.130	6.170	1.022	0.596	1.000	0.986	0.996	432	p53,_DNA-binding_domain	.	.	ID=COSV52661812;OCCURENCE=24(breast),3(liver),15(oesophagus),30(large_intestine),8(central_nervous_system),1(biliary_tract),1(vulva),18(ovary),1(bone),9(stomach),15(haematopoietic_and_lymphoid_tissue),2(urinary_tract),2(kidney),2(soft_tissue),9(pancreas),1(skin),2(prostate),11(lung),1(thyroid),6(upper_aerodigestive_tract),1(endometrium)	TP53	736	2	475	55	0.10377358490566	NA	TRUE
ENSG00000158270.12	.	BCM	GRCh38.p13	chr18	334825	334825	+	C	C	G	Missense_Mutation	SNP	ENST00000400256.5	exon6	c.G1733C	p.G578A	exonic	ENSG00000158270.12	.	nonsynonymous SNV	ENSG00000158270.12:ENST00000400256.5:exon6:c.G1733C:p.G578A	18p11.32	C3L-02897	.	.	.	.	.	.	.	.	.	19.20	D	T	D	D	D	D	H	D	D	0.555	D	D	D	0.915	0.977	0.831	0.248	D	D	D	D	D	D	2.737	22.900	0.850	D	D	0.626	6.194	0.470	4.895	1.000	0.615	0.574	0.598	0.655	.	5.390	4.520	3.521	1.022	0.596	0.996	0.889	0.626	878	.	.	.	ID=COSV101232129;OCCURENCE=1(stomach)	COLEC12	86	0	56	8	0.125	TRUE	NA
ENSG00000130304.17	.	BCM	GRCh38.p13	chr19	17486807	17486807	+	C	C	T	Missense_Mutation	SNP	ENST00000252595.12	exon2	c.C412T	p.R138W	exonic	ENSG00000130304.17	.	nonsynonymous SNV	ENSG00000130304.17:ENST00000252595.12:exon2:c.C412T:p.R138W	19p13.11	C3L-02897	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	H	T	D	0.831	T	T	D	0.482	0.707	0.752	1.202	T	T	D	T	D	D	3.983	26.900	0.999	D	D	0.660	6.595	0.534	5.486	0.017	0.646	0.588	0.645	0.655	.	4.920	3.880	2.961	0.943	0.596	1.000	0.997	0.979	940	AMP-dependent_synthetase/ligase	.	.	.	SLC27A1	242	0	166	9	0.0514285714285714	TRUE	NA
ENSG00000100372.15	.	BCM	GRCh38.p13	chr22	40777275	40777275	+	T	T	C	Missense_Mutation	SNP	ENST00000435456.7	exon6	c.A550G	p.M184V	exonic	ENSG00000100372.15	.	nonsynonymous SNV	ENSG00000100372.15:ENST00000435456.7:exon6:c.A550G:p.M184V	22q13.2	C3L-02897	.	.	.	.	.	.	.	.	.	11.20	D	T	B	B	D	D	N	T	D	0.840	T	T	D	0.591	0.623	0.809	0.613	T	T	D	D	D	D	2.972	23.400	0.993	D	D	0.163	3.144	0.354	4.049	1.000	0.707	0.725	0.725	0.714	.	5.860	5.860	7.905	1.138	0.665	1.000	1.000	0.998	245	.	.	.	.	SLC25A17	124	1	82	12	0.127659574468085	TRUE	TRUE
ENSG00000102271.14	.	BCM	GRCh38.p13	chrX	87518069	87518069	+	G	G	A	Missense_Mutation	SNP	ENST00000373119.9	exon1	c.G176A	p.R59K	exonic	ENSG00000102271.14	.	nonsynonymous SNV	ENSG00000102271.14:ENST00000373119.9:exon1:c.G176A:p.R59K	Xq21.31	C3L-02897	.	.	.	.	.	.	.	.	.	5.19	T	T	P	B	N	D	M	T	N	0.323	T	T	D	0.272	0.180	0.662	0.971	T	T	T	T	D	T	2.578	22.600	0.987	D	.	.	.	.	.	1.000	.	.	.	.	.	5.050	4.190	8.833	1.012	0.596	1.000	1.000	0.994	974	.	.	.	.	KLHL4	172	0	98	24	0.19672131147541	TRUE	TRUE
ENSG00000175707.9	.	BCM	GRCh38.p13	chr1	26950757	26950757	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000175707.9	ENST00000320567.6:exon3:c.1040-1G>T	.	.	1p36.11	C3L-02897	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.785	34	0.995	D	.	1.105	17.707	0.955	16.320	1.000	0.093	0.094	0.122	0.083	0.986	5.440	5.440	5.434	1.026	0.599	1.000	0.997	0.936	590	.	.	.	.	KDF1	179	1	109	12	0.0991735537190083	TRUE	TRUE
ENSG00000108375.12	.	BCM	GRCh38.p13	chr17	58363273	58363273	+	A	A	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000108375.12;ENSG00000285897.1	ENST00000584437.5:exon4:c.582+2T>A;ENST00000648873.1:exon4:c.582+2T>A	.	.	17q22	C3L-02897	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.593	34	0.992	D	.	1.126	18.727	0.978	17.543	1.000	0.099	0.105	0.078	0.059	0.978	5.680	5.680	8.473	1.312	0.691	1.000	0.831	0.965	308	.	.	.	.	RNF43	114	0	81	15	0.15625	TRUE	TRUE
ENSG00000119041.11	.	BCM	GRCh38.p13	chr2	196793043	196793043	+	C	C	T	Silent	SNP	ENST00000263956.8	exon3	c.G324A	p.E108E	exonic	ENSG00000119041.11	.	synonymous SNV	ENSG00000119041.11:ENST00000263956.8:exon3:c.G324A:p.E108E	2q33.1	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GTF3C3	299	5	219	14	0.0600858369098712	NA	TRUE
ENSG00000172752.14	.	BCM	GRCh38.p13	chr3	130440791	130440791	+	G	G	A	Silent	SNP	ENST00000265379.10	exon36	c.G6441A	p.A2147A	exonic	ENSG00000172752.14	.	synonymous SNV	ENSG00000172752.14:ENST00000265379.10:exon36:c.G6441A:p.A2147A	3q22.1	C3L-02897	0.0092	0.0017	0.0037	0	0.0076	0.0143	0.0086	0.0021	rs73214742	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55218157;OCCURENCE=1(stomach),1(pancreas)	COL6A5	214	1	119	13	0.0984848484848485	TRUE	TRUE
ENSG00000145934.16	.	BCM	GRCh38.p13	chr5	168262567	168262567	+	C	C	T	Silent	SNP	ENST00000518659.5	exon29	c.C8082T	p.R2694R	exonic	ENSG00000145934.16	.	synonymous SNV	ENSG00000145934.16:ENST00000518659.5:exon29:c.C8082T:p.R2694R	5q34	C3L-02897	0.0001	0	0	0	0	0.0002	0	0.0001	rs781070079	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TENM2	211	0	150	16	0.0963855421686747	TRUE	NA
ENSG00000130713.16	.	BCM	GRCh38.p13	chr9	130702163	130702163	+	C	C	A	Silent	SNP	ENST00000372358.10	exon7	c.C525A	p.S175S	exonic	ENSG00000130713.16	.	synonymous SNV	ENSG00000130713.16:ENST00000372358.10:exon7:c.C525A:p.S175S	9q34.12	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EXOSC2	190	0	128	13	0.0921985815602837	TRUE	TRUE
ENSG00000171794.4	.	BCM	GRCh38.p13	chr10	133230810	133230810	+	C	C	T	Silent	SNP	ENST00000304477.3	exon1	c.C522T	p.N174N	exonic	ENSG00000171794.4	.	synonymous SNV	ENSG00000171794.4:ENST00000304477.3:exon1:c.C522T:p.N174N	10q26.3	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UTF1	126	0	31	7	0.184210526315789	TRUE	TRUE
ENSG00000174885.12	.	BCM	GRCh38.p13	chr11	281522	281522	+	G	G	A	Silent	SNP	ENST00000312165.5	exon4	c.G1788A	p.G596G	exonic	ENSG00000174885.12	.	synonymous SNV	ENSG00000174885.12:ENST00000312165.5:exon4:c.G1788A:p.G596G	11p15.5	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NLRP6	128	0	61	11	0.152777777777778	TRUE	NA
ENSG00000110435.12	.	BCM	GRCh38.p13	chr11	34916721	34916721	+	C	C	T	Silent	SNP	ENST00000227868.9	exon1	c.C66T	p.G22G	exonic	ENSG00000110435.12	.	synonymous SNV	ENSG00000110435.12:ENST00000227868.9:exon1:c.C66T:p.G22G	11p13	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDHX	354	0	231	13	0.0532786885245902	NA	TRUE
ENSG00000069329.18	.	BCM	GRCh38.p13	chr16	46662270	46662270	+	G	G	A	Silent	SNP	ENST00000299138.12	exon15	c.C2040T	p.G680G	exonic	ENSG00000069329.18	.	synonymous SNV	ENSG00000069329.18:ENST00000299138.12:exon15:c.C2040T:p.G680G	16q11.2	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VPS35	457	0	296	27	0.0835913312693498	TRUE	TRUE
ENSG00000126457.21	.	BCM	GRCh38.p13	chr19	49680567	49680567	+	C	C	T	Silent	SNP	ENST00000454376.6	exon3	c.C171T	p.Y57Y	exonic	ENSG00000126457.21	.	synonymous SNV	ENSG00000126457.21:ENST00000454376.6:exon3:c.C171T:p.Y57Y	19q13.33	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRMT1	297	0	195	18	0.0845070422535211	TRUE	NA
ENSG00000228672.4	.	BCM	GRCh38.p13	chr5	139396921	139396921	+	A	A	G	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000228672.4;ENSG00000170469.10	dist=1817;dist=4580	.	.	5q31.2	C3L-02897	.	.	.	.	.	.	.	.	.	4.18	D	T	B	B	.	N	N	.	N	0.454	T	T	T	0.163	0.292	0.030	.	T	T	T	T	D	T	2.326	21.700	0.977	D	D	-0.128	2.087	0.087	2.680	1.000	0.722	0.699	0.696	0.568	.	5.450	5.450	4.783	1.312	0.756	0.990	0.988	0.977	625	.	.	.	.	PROB1	189	1	169	21	0.110526315789474	TRUE	TRUE
ENSG00000196364.9	.	BCM	GRCh38.p13	chr16	1262635	1262635	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000196364.9	.	.	.	16p13.3	C3L-02897	7.273e-05	0	0	0.0051	0	0	0	0	rs770982416	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRSS29P	536	0	376	25	0.0623441396508728	TRUE	NA
ENSG00000162032.16	.	BCM	GRCh38.p13	chr16	1781199	1781199	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000162032.16	.	.	.	16p13.3	C3L-02897	6.101e-05	0	0	0	0	0.0002	0	0	rs765592684	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPSB3	230	0	155	32	0.171122994652406	TRUE	NA
ENSG00000168096.15	.	BCM	GRCh38.p13	chr16	4700858	4700858	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000168096.15	.	.	.	16p13.3	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100422895;OCCURENCE=1(large_intestine)	ANKS3	401	0	274	25	0.0836120401337793	TRUE	NA
ENSG00000234684.7	.	BCM	GRCh38.p13	chr20	1336416	1336416	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000234684.7	.	.	.	20p13	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SDCBP2-AS1	380	0	301	26	0.0795107033639144	TRUE	NA
ENSG00000101966.12	.	BCM	GRCh38.p13	chrX	123908626	123908626	+	T	T	G	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000101966.12	ENST00000371199.7:c.*1445T>G	.	.	Xq25	C3L-02897	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	XIAP	48	0	22	5	0.185185185185185	TRUE	NA
ENSG00000065243.20	.	BCM	GRCh38.p13	chr1	88828594	88828594	+	G	G	A	Missense_Mutation	SNP	ENST00000370521.8	exon19	c.G2533A	p.V845M	exonic	ENSG00000065243.20	.	nonsynonymous SNV	ENSG00000065243.20:ENST00000370521.8:exon19:c.G2533A:p.V845M	1p22.2	C3L-01687	.	.	.	.	.	.	.	.	.	12.20	D	D	P	B	U	D	M	T	D	0.895	T	T	T	0.449	0.667	0.837	1.257	D	T	D	D	D	D	3.497	24.700	0.997	D	D	0.695	7.054	0.733	8.426	1.000	0.732	0.744	0.725	0.728	.	5.400	5.400	9.602	1.176	0.676	1.000	0.996	0.969	885	Protein_kinase_domain	.	.	ID=COSV65143304;OCCURENCE=1(central_nervous_system)	PKN2	108	0	161	26	0.13903743315508	TRUE	TRUE
ENSG00000163534.15	.	BCM	GRCh38.p13	chr1	157804060	157804060	+	G	G	T	Missense_Mutation	SNP	ENST00000368176.8	exon3	c.C104A	p.T35N	exonic	ENSG00000163534.15	.	nonsynonymous SNV	ENSG00000163534.15:ENST00000368176.8:exon3:c.C104A:p.T35N	1q23.1	C3L-01687	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	D	0.271	T	T	T	0.036	0.454	0.232	0.129	T	T	T	T	T	T	1.083	12.600	0.948	D	N	-0.536	1.106	-0.473	1.246	0.254	0.560	0.624	0.574	0.564	.	4.550	2.680	0.470	0.225	-0.106	0.979	0.082	0.026	814	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	FCRL1	266	1	450	80	0.150943396226415	TRUE	NA
ENSG00000162670.11	.	BCM	GRCh38.p13	chr1	190226235	190226235	+	C	C	A	Nonsense_Mutation	SNP	ENST00000367462.5	exon6	c.G808T	p.E270X	exonic	ENSG00000162670.11	.	stopgain	ENSG00000162670.11:ENST00000367462.5:exon6:c.G808T:p.E270X	1q31.1	C3L-01687	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.302	.	.	.	.	.	.	.	.	.	D	D	.	.	7.275	37	0.998	D	N	1.136	19.228	0.997	18.669	0.997	0.487	0.574	0.574	0.564	.	5.680	5.680	5.715	1.026	0.599	1.000	1.000	0.996	726	.	.	.	.	BRINP3	216	0	319	56	0.149333333333333	TRUE	TRUE
ENSG00000183780.13	.	BCM	GRCh38.p13	chr1	234323068	234323068	+	T	T	C	Missense_Mutation	SNP	ENST00000366617.3	exon7	c.T1091C	p.I364T	exonic	ENSG00000183780.13	.	nonsynonymous SNV	ENSG00000183780.13:ENST00000366617.3:exon7:c.T1091C:p.I364T	1q42.2	C3L-01687	.	.	.	.	.	.	.	.	.	13.20	D	D	B	B	N	D	M	T	D	0.784	T	T	D	0.318	0.527	0.103	1.778	D	T	D	D	D	D	3.536	24.800	0.998	D	D	0.107	2.912	0.230	3.336	1.000	0.696	0.858	0.692	0.584	.	5.620	4.500	7.667	1.138	0.609	1.000	1.000	0.995	969	.	.	.	.	SLC35F3	424	1	821	66	0.0744081172491545	TRUE	TRUE
ENSG00000144118.14	.	BCM	GRCh38.p13	chr2	120285967	120285967	+	G	G	A	Missense_Mutation	SNP	ENST00000272519.10	exon3	c.G208A	p.A70T	exonic	ENSG00000144118.14	.	nonsynonymous SNV	ENSG00000144118.14:ENST00000272519.10:exon3:c.G208A:p.A70T	2q14.2	C3L-01687	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.906	D	D	D	0.795	0.783	0.955	1.951	D	D	D	D	D	D	4.060	27.400	0.999	D	D	0.883	10.612	0.783	9.637	1.000	0.706	0.719	0.710	0.714	.	5.950	5.950	9.858	1.176	0.676	1.000	0.941	0.900	768	Small_GTP-binding_protein_domain	.	.	.	RALB	411	0	604	111	0.155244755244755	TRUE	NA
ENSG00000114923.17	.	BCM	GRCh38.p13	chr2	219629149	219629149	+	C	C	T	Missense_Mutation	SNP	ENST00000358055.8	exon4	c.C223T	p.R75W	exonic	ENSG00000114923.17	.	nonsynonymous SNV	ENSG00000114923.17:ENST00000358055.8:exon4:c.C223T:p.R75W	2q35	C3L-01687	1.902e-05	0	0	0	0	3.339e-05	0	0	rs764732530	14.20	D	D	D	D	D	D	L	T	D	0.861	T	T	D	0.313	0.460	0.651	.	D	D	T	T	D	D	4.451	32	0.999	D	D	0.608	6.003	0.570	5.870	1.000	0.646	0.590	0.645	0.605	.	4.750	4.750	2.346	1.026	0.599	1.000	1.000	0.999	156	.	.	.	.	SLC4A3	39	0	59	9	0.132352941176471	TRUE	NA
ENSG00000159650.9	.	BCM	GRCh38.p13	chr3	126489297	126489297	+	C	C	T	Missense_Mutation	SNP	ENST00000290868.7	exon17	c.G1687A	p.D563N	exonic	ENSG00000159650.9	.	nonsynonymous SNV	ENSG00000159650.9:ENST00000290868.7:exon17:c.G1687A:p.D563N	3q21.3	C3L-01687	6.594e-05	0	0	0.0002	0	8.998e-05	0	0	rs372570937	16.20	D	D	D	D	D	D	H	T	D	0.975	D	D	D	0.613	.	0.843	0.400	D	T	T	T	D	D	3.376	24.300	0.999	D	D	0.661	6.609	0.446	4.699	1.000	0.487	0.574	0.547	0.613	.	4.590	4.590	7.187	0.980	0.549	1.000	0.143	0.263	846	Urocanase,_C-terminal_domain	.	.	ID=COSV99330990;OCCURENCE=1(large_intestine)	UROC1	356	0	670	144	0.176904176904177	TRUE	NA
ENSG00000151458.12	.	BCM	GRCh38.p13	chr4	124672280	124672280	+	A	A	C	Missense_Mutation	SNP	ENST00000504087.6	exon4	c.T997G	p.L333V	exonic	ENSG00000151458.12	.	nonsynonymous SNV	ENSG00000151458.12:ENST00000504087.6:exon4:c.T997G:p.L333V	4q28.1	C3L-01687	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	L	T	N	0.826	T	T	D	0.551	0.705	0.943	0.837	D	T	D	D	D	D	3.246	24.000	0.994	D	N	0.151	3.093	0.102	2.742	1.000	0.672	0.588	0.609	0.711	.	5.430	4.580	4.388	0.240	-0.137	1.000	0.964	0.901	933	.	.	.	.	ANKRD50	299	1	447	90	0.167597765363128	TRUE	TRUE
ENSG00000150627.15	.	BCM	GRCh38.p13	chr4	176128827	176128827	+	T	T	A	Missense_Mutation	SNP	ENST00000280190.8	exon7	c.T952A	p.L318I	exonic	ENSG00000150627.15	.	nonsynonymous SNV	ENSG00000150627.15:ENST00000280190.8:exon7:c.T952A:p.L318I	4q34.2	C3L-01687	.	.	.	.	.	.	.	.	.	6.20	T	D	P	B	D	D	L	T	N	0.582	T	T	T	0.110	0.337	0.745	0.205	T	T	T	T	D	D	2.151	20.500	0.985	D	N	0.030	2.618	0.128	2.853	0.000	0.554	0.588	0.618	0.564	.	5.450	4.270	2.133	1.138	0.665	1.000	0.983	0.994	970	.	.	.	.	WDR17	217	0	330	24	0.0677966101694915	TRUE	TRUE
ENSG00000040731.10	.	BCM	GRCh38.p13	chr5	24593260	24593260	+	C	C	G	Missense_Mutation	SNP	ENST00000264463.8	exon2	c.G231C	p.K77N	exonic	ENSG00000040731.10	.	nonsynonymous SNV	ENSG00000040731.10:ENST00000264463.8:exon2:c.G231C:p.K77N	5p14.2	C3L-01687	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	D	D	H	T	D	0.655	T	T	D	0.270	0.528	0.797	0.626	D	T	T	T	D	D	5.084	33	0.998	D	D	0.541	5.368	0.472	4.917	0.137	0.487	0.574	0.574	0.564	.	4.370	3.490	7.104	1.026	0.549	1.000	0.999	0.736	939	Cadherin-like	.	.	.	CDH10	176	0	232	35	0.131086142322097	TRUE	TRUE
ENSG00000205359.10	.	BCM	GRCh38.p13	chr5	102399644	102399644	+	G	G	T	Nonsense_Mutation	SNP	ENST00000506729.6	exon10	c.C1725A	p.C575X	exonic	ENSG00000205359.10	.	stopgain	ENSG00000205359.10:ENST00000506729.6:exon10:c.C1725A:p.C575X	5q21.1	C3L-01687	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	D	A	.	.	.	0.260	.	.	.	.	.	.	.	.	.	D	D	.	.	5.247	33	0.983	N	N	-0.093	2.198	-0.396	1.379	0.000	0.487	0.574	0.574	0.564	.	5.420	1.200	0.461	0.073	-0.106	0.505	0.917	0.561	251	.	.	.	.	SLCO6A1	170	0	247	16	0.0608365019011407	TRUE	TRUE
ENSG00000105851.11	.	BCM	GRCh38.p13	chr7	106868991	106868991	+	G	G	A	Missense_Mutation	SNP	ENST00000496166.6	exon2	c.G1430A	p.R477H	exonic	ENSG00000105851.11	.	nonsynonymous SNV	ENSG00000105851.11:ENST00000496166.6:exon2:c.G1430A:p.R477H	7q22.3	C3L-01687	4.953e-05	0	0	0	0	9.011e-05	0	0	rs200175951	1.20	T	T	B	B	N	N	N	T	N	0.090	T	T	T	0.168	.	0.381	0.507	T	T	T	T	T	D	1.892	18.430	0.929	N	N	-0.548	1.084	-0.394	1.382	1.000	0.615	0.654	0.574	0.655	.	6.020	1.220	3.002	-0.101	0.676	0.986	0.912	0.990	274	Phosphatidylinositol_3-kinase,_C2_domain	.	.	ID=COSV63245400;OCCURENCE=1(oesophagus),2(large_intestine),2(central_nervous_system),1(prostate),1(endometrium)	PIK3CG	259	0	414	28	0.0633484162895928	TRUE	TRUE
ENSG00000154415.8	.	BCM	GRCh38.p13	chr7	113879942	113879942	+	C	C	T	Missense_Mutation	SNP	ENST00000284601.4	exon4	c.G1150A	p.V384I	exonic	ENSG00000154415.8	.	nonsynonymous SNV	ENSG00000154415.8:ENST00000284601.4:exon4:c.G1150A:p.V384I	7q31.1	C3L-01687	0.0001	0	0	0	0	0	0.0011	0.0008	rs533705714	0.20	T	T	B	B	N	N	N	T	N	0.020	T	T	T	0.038	0.079	0.302	0.038	T	T	T	T	T	T	-0.248	0.403	0.641	N	N	-1.460	0.094	-1.361	0.172	0.000	0.487	0.574	0.574	0.564	.	5.550	-2.670	0.604	-0.509	-0.836	0.311	0.638	0.677	801	.	.	.	ID=COSV52882352;OCCURENCE=1(stomach)	PPP1R3A	180	0	299	21	0.065625	TRUE	TRUE
ENSG00000147647.13	.	BCM	GRCh38.p13	chr8	104428000	104428000	+	C	C	T	Missense_Mutation	SNP	ENST00000351513.7	exon6	c.G1072A	p.V358I	exonic	ENSG00000147647.13	.	nonsynonymous SNV	ENSG00000147647.13:ENST00000351513.7:exon6:c.G1072A:p.V358I	8q22.3	C3L-01687	1.647e-05	9.61e-05	0	0.0001	0	0	0	0	rs769403392	7.20	T	T	B	B	N	D	N	D	N	0.170	T	D	D	0.205	0.597	0.767	0.121	T	T	T	T	T	D	1.367	14.860	0.994	D	D	-0.226	1.804	-0.032	2.253	1.000	0.487	0.590	0.574	0.657	.	5.950	5.080	1.841	1.026	0.599	0.913	0.997	0.997	501	Amidohydrolase-related	.	.	.	DPYS	487	1	748	123	0.141216991963261	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971112	21971112	+	G	G	C	Missense_Mutation	SNP	ENST00000304494.9	exon2	c.C247G	p.H83D	exonic	ENSG00000147889.17	.	nonsynonymous SNV	ENSG00000147889.17:ENST00000304494.9:exon2:c.C247G:p.H83D	9p21.3	C3L-01687	.	.	.	.	.	.	.	.	rs121913385	14.18	D	D	D	D	.	D	.	T	D	0.918	T	T	D	0.771	0.726	0.934	1.433	T	D	D	D	D	D	4.569	32	0.995	D	D	0.745	7.793	0.793	9.921	1.000	0.677	0.383	0.608	0.601	.	5.930	5.930	9.231	1.176	0.676	1.000	0.843	0.926	900	Ankyrin_repeat-containing_domain	.	.	ID=COSV58690009;OCCURENCE=2(breast),1(liver),2(pancreas),2(skin),1(lung)	CDKN2A	385	0	750	191	0.202975557917109	TRUE	TRUE
ENSG00000156650.14	.	BCM	GRCh38.p13	chr10	75030180	75030180	+	G	G	A	Missense_Mutation	SNP	ENST00000287239.10	exon18	c.G5356A	p.E1786K	exonic	ENSG00000156650.14	.	nonsynonymous SNV	ENSG00000156650.14:ENST00000287239.10:exon18:c.G5356A:p.E1786K	10q22.2	C3L-01687	.	.	.	.	.	.	.	.	rs906740657	17.19	D	D	D	D	D	D	M	D	D	0.608	D	D	D	0.576	0.405	0.590	0.621	T	T	D	D	D	.	3.679	25.300	0.998	D	D	0.716	7.344	0.747	8.731	1.000	0.707	0.702	0.725	0.636	.	5.540	5.540	7.757	1.176	0.676	1.000	0.969	0.949	23	.	.	.	ID=COSV54744157;OCCURENCE=1(urinary_tract)	KAT6B	327	0	615	40	0.0610687022900763	TRUE	TRUE
ENSG00000010379.16	.	BCM	GRCh38.p13	chr12	224484	224484	+	G	G	A	Missense_Mutation	SNP	ENST00000343164.9	exon10	c.C1090T	p.R364W	exonic	ENSG00000010379.16	.	nonsynonymous SNV	ENSG00000010379.16:ENST00000343164.9:exon10:c.C1090T:p.R364W	12p13.33	C3L-01687	9.965e-05	9.854e-05	0	0	0	0.0001	0	0.0002	rs149299701	17.20	D	D	D	D	D	D	M	T	D	0.791	D	D	D	0.874	.	0.960	0.437	T	T	D	D	D	D	4.326	29.800	0.999	D	D	0.637	6.319	0.548	5.630	0.000	0.516	0.610	0.547	0.564	.	5.610	3.600	3.950	1.176	0.665	1.000	0.975	0.832	934	.	.	.	ID=COSV58255715;OCCURENCE=2(large_intestine)	SLC6A13	240	0	464	36	0.072	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01687	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	349	1	543	88	0.13946117274168	TRUE	TRUE
ENSG00000172915.18	.	BCM	GRCh38.p13	chr13	35161796	35161796	+	T	T	A	Missense_Mutation	SNP	ENST00000400445.7	exon23	c.T3908A	p.V1303D	exonic	ENSG00000172915.18	.	nonsynonymous SNV	ENSG00000172915.18:ENST00000400445.7:exon23:c.T3908A:p.V1303D	13q13.3	C3L-01687	.	.	.	.	.	.	.	.	.	9.20	T	T	P	B	D	D	L	T	N	0.894	T	T	D	0.210	0.322	0.614	0.946	T	T	D	D	D	D	3.517	24.800	0.962	D	D	0.126	2.990	0.244	3.408	1.000	0.626	0.588	0.805	0.568	.	5.040	5.040	7.951	1.138	0.609	1.000	0.908	0.985	919	.	.	.	.	NBEA	298	1	535	80	0.130081300813008	TRUE	TRUE
ENSG00000083520.15	.	BCM	GRCh38.p13	chr13	72771881	72771881	+	-	NA	A	Frame_Shift_Ins	INS	ENST00000377767.9	exon11	c.1518dupT	p.A507Cfs*2	exonic	ENSG00000083520.15	.	frameshift insertion	ENSG00000083520.15:ENST00000377767.9:exon11:c.1518dupT:p.A507Cfs*2	13q21.33	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DIS3	NA	NA	NA	NA	NA	NA	NA
ENSG00000128731.18	.	BCM	GRCh38.p13	chr15	28270723	28270723	+	G	G	A	Missense_Mutation	SNP	ENST00000261609.13	exon10	c.C1229T	p.P410L	exonic	ENSG00000128731.18	.	nonsynonymous SNV	ENSG00000128731.18:ENST00000261609.13:exon10:c.C1229T:p.P410L	15q13.1	C3L-01687	8.243e-06	0	8.64e-05	0	0	0	0	0	rs779830734	11.19	D	.	D	D	D	D	M	T	D	0.834	T	T	T	0.367	0.470	0.440	0.147	T	T	T	T	D	D	4.077	27.600	0.998	D	D	0.707	7.224	0.721	8.159	1.000	0.707	0.546	0.725	0.636	.	5.700	5.700	9.937	1.150	0.646	1.000	0.688	0.403	856	.	.	.	ID=COSV55334806;OCCURENCE=1(large_intestine),1(bone)	HERC2	205	0	350	57	0.14004914004914	NA	TRUE
ENSG00000134160.14	.	BCM	GRCh38.p13	chr15	31038045	31038045	+	G	G	A	Missense_Mutation	SNP	ENST00000397795.6	exon18	c.C2372T	p.T791M	exonic	ENSG00000134160.14	.	nonsynonymous SNV	ENSG00000134160.14:ENST00000397795.6:exon18:c.C2372T:p.T791M	15q13.3	C3L-01687	5.801e-05	0.0001	0	0	0.0002	2.999e-05	0	0.0002	rs377044822	0.20	T	T	B	B	N	N	N	T	N	0.097	T	T	T	0.064	.	0.110	0.215	T	T	T	T	T	T	0.803	9.420	0.908	N	N	-1.574	0.061	-1.499	0.108	0.000	0.487	0.574	0.547	0.564	.	5.330	-1.090	0.341	-0.957	-0.704	0.041	0.317	0.187	819	.	.	.	ID=COSV99855070;OCCURENCE=1(large_intestine)	TRPM1	389	0	577	86	0.129713423831071	TRUE	NA
ENSG00000103222.19	.	BCM	GRCh38.p13	chr16	16106738	16106738	+	-	NA	CAGCTCAG	Frame_Shift_Ins	INS	ENST00000399410.8	exon21	c.2736_2737insCAGCTCAG	p.S918Afs*33	exonic	ENSG00000103222.19	.	frameshift insertion	ENSG00000103222.19:ENST00000399410.8:exon21:c.2736_2737insCAGCTCAG:p.S918Afs*33	16p13.11	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABCC1	NA	NA	NA	NA	NA	NA	NA
ENSG00000277481.1	.	BCM	GRCh38.p13	chr16	71978259	71978259	+	-	NA	T	Frame_Shift_Ins	INS	ENST00000620267.1	exon10	c.1522dupA	p.I508Nfs*2	exonic	ENSG00000277481.1	.	frameshift insertion	ENSG00000277481.1:ENST00000620267.1:exon10:c.1522dupA:p.I508Nfs*2	16q22.2	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PKD1L3	NA	NA	NA	NA	NA	NA	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674244	7674258	+	CTGTTACACATGTAG	CTGTTACACATGTAG	-	In_Frame_Del	DEL	ENST00000269305.8	exon7	c.705_719del	p.Y236_S240del	exonic	ENSG00000141510.17	.	nonframeshift deletion	ENSG00000141510.17:ENST00000269305.8:exon7:c.705_719del:p.Y236_S240del	17p13.1	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	400	0	534	93	0.148325358851675	TRUE	TRUE
ENSG00000101680.15	.	BCM	GRCh38.p13	chr18	7049116	7049116	+	G	G	A	Missense_Mutation	SNP	ENST00000389658.4	exon5	c.C730T	p.R244W	exonic	ENSG00000101680.15	.	nonsynonymous SNV	ENSG00000101680.15:ENST00000389658.4:exon5:c.C730T:p.R244W	18p11.31	C3L-01687	4.119e-05	0	0.0002	0	0	4.495e-05	0	0	rs200626690	13.20	D	D	D	D	D	D	M	T	D	0.383	T	T	T	0.319	.	0.454	0.520	T	D	T	T	D	D	4.232	29.000	0.999	D	D	0.625	6.191	0.588	6.072	1.000	0.732	0.574	0.744	0.564	.	5.860	4.980	3.149	0.207	0.676	1.000	0.673	0.966	882	Laminin,_N-terminal	.	.	ID=COSV101055738;OCCURENCE=1(prostate),1(endometrium)	LAMA1	365	1	711	89	0.11125	TRUE	NA
ENSG00000101654.17	.	BCM	GRCh38.p13	chr18	13740203	13740203	+	G	G	A	Missense_Mutation	SNP	ENST00000383314.6	exon6	c.G716A	p.R239Q	exonic	ENSG00000101654.17	.	nonsynonymous SNV	ENSG00000101654.17:ENST00000383314.6:exon6:c.G716A:p.R239Q	18p11.21	C3L-01687	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	H	.	D	0.923	D	D	D	0.610	0.941	0.796	0.740	T	T	D	D	D	D	4.371	31	1.000	D	D	1.056	15.803	0.996	18.604	1.000	0.732	0.744	0.744	0.714	.	5.760	5.760	9.184	1.155	0.676	1.000	1.000	1.000	708	mRNA_(guanine-N(7))-methyltransferase_domain	.	.	.	RNMT	316	1	439	33	0.0699152542372881	TRUE	NA
ENSG00000141858.12	.	BCM	GRCh38.p13	chr19	14090367	14090367	+	-	NA	GTGGTG	In_Frame_Ins	INS	ENST00000533683.7	exon1	c.53_54insCACCAC	p.T18_A19insTT	exonic	ENSG00000141858.12	.	nonframeshift insertion	ENSG00000141858.12:ENST00000533683.7:exon1:c.53_54insCACCAC:p.T18_A19insTT	19p13.12	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SAMD1	NA	NA	NA	NA	NA	NA	NA
ENSG00000159905.14	.	BCM	GRCh38.p13	chr19	43967181	43967181	+	G	G	A	Missense_Mutation	SNP	ENST00000251269.9	exon6	c.G1679A	p.R560Q	exonic	ENSG00000159905.14	.	nonsynonymous SNV	ENSG00000159905.14:ENST00000251269.9:exon6:c.G1679A:p.R560Q	19q13.31	C3L-01687	0.0004	0.0045	0.0002	0	0	1.499e-05	0	6.058e-05	rs147168648	3.19	D	D	D	P	.	N	L	T	N	0.150	T	T	T	0.051	.	0.355	0.030	T	T	T	T	T	T	1.812	17.820	0.999	N	N	0.005	2.529	-0.138	1.943	0.002	0.563	0.588	0.609	0.492	.	2.770	1.610	0.240	-0.336	-0.206	0.000	0.014	0.012	656	Zinc_finger_C2H2-type	.	.	ID=COSV104569801;OCCURENCE=1(central_nervous_system)	ZNF221	158	0	295	95	0.243589743589744	TRUE	NA
ENSG00000105287.12	.	BCM	GRCh38.p13	chr19	46694126	46694126	+	G	G	A	Missense_Mutation	SNP	ENST00000433867.5	exon11	c.C1325T	p.P442L	exonic	ENSG00000105287.12	.	nonsynonymous SNV	ENSG00000105287.12:ENST00000433867.5:exon11:c.C1325T:p.P442L	19q13.32	C3L-01687	8.351e-06	0	0	0	0	1.521e-05	0	0	rs763539356	17.20	D	D	P	P	D	D	M	T	D	0.930	D	D	D	0.711	0.768	0.821	1.920	D	D	D	D	D	D	3.992	26.900	0.999	D	D	0.774	8.288	0.712	7.988	1.000	0.707	0.702	0.725	0.714	.	4.730	4.730	9.948	1.176	0.676	1.000	0.639	0.656	929	Pleckstrin_homology_domain	.	.	ID=COSV99354200;OCCURENCE=1(cervix)	PRKD2	118	0	241	50	0.171821305841924	TRUE	NA
ENSG00000089177.18	.	BCM	GRCh38.p13	chr20	16406409	16406409	+	G	G	A	Missense_Mutation	SNP	ENST00000354981.6	exon16	c.C1660T	p.P554S	exonic	ENSG00000089177.18	.	nonsynonymous SNV	ENSG00000089177.18:ENST00000354981.6:exon16:c.C1660T:p.P554S	20p12.1	C3L-01687	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	L	D	D	0.826	D	D	D	0.703	0.436	0.900	0.559	T	D	D	D	D	D	4.077	27.600	0.999	D	D	0.863	10.145	0.880	12.929	1.000	0.638	0.670	0.659	0.568	.	5.950	5.950	9.158	1.176	0.676	1.000	0.983	0.996	801	.	.	.	.	KIF16B	219	0	382	26	0.0637254901960784	NA	TRUE
ENSG00000101191.17	.	BCM	GRCh38.p13	chr20	62894154	62894158	+	TTTTT	TTTTT	-	Frame_Shift_Del	DEL	ENST00000395343.6	exon12	c.2609_2613del	p.K870Tfs*8	exonic	ENSG00000101191.17	.	frameshift deletion	ENSG00000101191.17:ENST00000395343.6:exon12:c.2609_2613del:p.K870Tfs*8	20q13.33	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DIDO1	126	0	220	35	0.137254901960784	TRUE	TRUE
ENSG00000196924.18	.	BCM	GRCh38.p13	chrX	154366368	154366368	+	C	C	T	Missense_Mutation	SNP	ENST00000369850.10	exon8	c.G1168A	p.G390S	exonic	ENSG00000196924.18	.	nonsynonymous SNV	ENSG00000196924.18:ENST00000369850.10:exon8:c.G1168A:p.G390S	Xq28	C3L-01687	1.156e-05	0.0001	0	0	0	0	0	0	rs199766573	18.19	D	D	D	D	D	D	H	D	D	0.793	D	D	D	0.903	.	0.978	1.426	T	D	D	D	D	D	3.550	24.900	0.847	D	.	.	.	.	.	1.000	.	.	.	.	.	4.710	4.710	7.849	1.021	0.543	1.000	0.595	0.546	86	.	.	.	.	FLNA	330	2	774	55	0.0663449939686369	TRUE	NA
ENSG00000143252.15	.	BCM	GRCh38.p13	chr1	161356711	161356711	+	C	C	T	Silent	SNP	ENST00000367975.7	exon5	c.C276T	p.L92L	exonic	ENSG00000143252.15	.	synonymous SNV	ENSG00000143252.15:ENST00000367975.7:exon5:c.C276T:p.L92L	1q23.3	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100713603;OCCURENCE=1(skin)	SDHC	341	1	616	101	0.140864714086471	TRUE	TRUE
ENSG00000075340.23	.	BCM	GRCh38.p13	chr2	70692403	70692403	+	C	C	T	Silent	SNP	ENST00000264436.9	exon7	c.G705A	p.A235A	exonic	ENSG00000075340.23	.	synonymous SNV	ENSG00000075340.23:ENST00000264436.9:exon7:c.G705A:p.A235A	2p13.3	C3L-01687	2.794e-05	0	0	0	0	4.811e-05	0	0	rs781804198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52472118;OCCURENCE=1(large_intestine)	ADD2	43	0	105	17	0.139344262295082	TRUE	TRUE
ENSG00000198648.11	.	BCM	GRCh38.p13	chr2	168075205	168075205	+	A	A	G	Silent	SNP	ENST00000355999.5	exon11	c.T1116C	p.G372G	exonic	ENSG00000198648.11	.	synonymous SNV	ENSG00000198648.11:ENST00000355999.5:exon11:c.T1116C:p.G372G	2q24.3	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STK39	237	0	391	26	0.0623501199040767	TRUE	TRUE
ENSG00000113296.14	.	BCM	GRCh38.p13	chr5	80059490	80059490	+	C	C	T	Silent	SNP	ENST00000350881.6	exon6	c.C783T	p.C261C	exonic	ENSG00000113296.14	.	synonymous SNV	ENSG00000113296.14:ENST00000350881.6:exon6:c.C783T:p.C261C	5q14.1	C3L-01687	8.237e-06	0	8.639e-05	0	0	0	0	0	rs561944130	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	THBS4	211	0	299	35	0.104790419161677	TRUE	NA
ENSG00000148396.18	.	BCM	GRCh38.p13	chr9	136476359	136476359	+	C	C	T	Silent	SNP	ENST00000313050.11	exon1	c.G1257A	p.G419G	exonic	ENSG00000148396.18	.	synonymous SNV	ENSG00000148396.18:ENST00000313050.11:exon1:c.G1257A:p.G419G	9q34.3	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEC16A	221	0	443	82	0.156190476190476	TRUE	TRUE
ENSG00000161681.15	.	BCM	GRCh38.p13	chr19	50667220	50667220	+	T	T	C	Silent	SNP	ENST00000293441.5	exon22	c.A4740G	p.P1580P	exonic	ENSG00000161681.15	.	synonymous SNV	ENSG00000161681.15:ENST00000293441.5:exon22:c.A4740G:p.P1580P	19q13.33	C3L-01687	0.0001	0	0	0	0	0.0002	0	0	rs763099836	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SHANK1	170	0	311	85	0.214646464646465	TRUE	NA
ENSG00000089177.18	.	BCM	GRCh38.p13	chr20	16406389	16406389	+	G	G	A	Silent	SNP	ENST00000354981.6	exon16	c.C1680T	p.L560L	exonic	ENSG00000089177.18	.	synonymous SNV	ENSG00000089177.18:ENST00000354981.6:exon16:c.C1680T:p.L560L	20p12.1	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61706295;OCCURENCE=1(skin)	KIF16B	164	0	293	16	0.0517799352750809	TRUE	TRUE
ENSG00000171940.13	.	BCM	GRCh38.p13	chr20	53577105	53577105	+	T	T	C	Silent	SNP	ENST00000371471.6	exon4	c.A1659G	p.Q553Q	exonic	ENSG00000171940.13	.	synonymous SNV	ENSG00000171940.13:ENST00000371471.6:exon4:c.A1659G:p.Q553Q	20q13.2	C3L-01687	8.238e-06	0	0	0	0	0	0	6.056e-05	rs752565233	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF217	368	0	677	96	0.124191461836999	TRUE	NA
ENSG00000181433.9	.	BCM	GRCh38.p13	chrX	135908541	135908541	+	C	C	T	Silent	SNP	ENST00000324447.7	exon12	c.C1365T	p.N455N	exonic	ENSG00000181433.9	.	synonymous SNV	ENSG00000181433.9:ENST00000324447.7:exon12:c.C1365T:p.N455N	Xq26.3	C3L-01687	1.17e-05	0	0	0	0	0	0	0.0001	rs782556186	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100186857;OCCURENCE=1(stomach)	SAGE1	141	0	218	35	0.138339920948617	TRUE	NA
ENSG00000269934.3	.	BCM	GRCh38.p13	chr1	228272003	228272003	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000269934.3	.	.	.	1q42.13	C3L-01687	.	.	.	.	.	.	.	.	.	0.13	.	T	.	.	.	N	.	T	.	0.345	T	T	T	0.178	.	0.171	0.339	T	.	T	T	T	T	0.629	7.792	0.493	N	N	-0.576	1.032	-0.729	0.859	0.955	0.696	0.610	0.723	0.421	.	4.950	0.924	-0.014	0.069	-0.299	0.000	0.305	0.003	445	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	AL353593.1	277	0	599	78	0.115214180206795	TRUE	TRUE
ENSG00000105339.10	.	BCM	GRCh38.p13	chr8	141158198	141158198	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000105339.10	.	.	.	8q24.3	C3L-01687	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DENND3	129	0	252	54	0.176470588235294	TRUE	NA
ENSG00000153930.12	.	BCM	GRCh38.p13	chr17	56510565	56510565	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000153930.12;ENSG00000243058.1	dist=27919;dist=62475	.	.	17q22	C3L-01687	.	.	.	.	.	.	.	.	.	6.10	.	D	.	.	.	D	.	T	.	0.258	.	.	D	.	.	0.729	.	.	T	T	T	.	D	4.311	29.700	0.999	D	D	.	.	.	.	1.000	0.526	0.574	0.616	0.564	.	4.830	4.830	9.943	1.176	0.676	1.000	1.000	0.997	56	.	.	.	.	ANKFN1	356	0	627	81	0.114406779661017	TRUE	TRUE
ENSG00000281732.1	.	BCM	GRCh38.p13	chr22	48544693	48544693	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000281732.1	.	.	.	22q13.32	C3L-01687	.	.	.	.	.	.	.	.	rs867817171	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	Z84468.1	124	0	213	47	0.180769230769231	TRUE	NA
ENSG00000174332.5	.	BCM	GRCh38.p13	chr1	53529924	53529924	+	C	C	T	Missense_Mutation	SNP	ENST00000312233.4	exon4	c.G824A	p.R275Q	exonic	ENSG00000174332.5	.	nonsynonymous SNV	ENSG00000174332.5:ENST00000312233.4:exon4:c.G824A:p.R275Q	1p32.3	C3N-02940	1.662e-05	0	0	0	0	3.028e-05	0	0	rs142254031	10.20	D	T	D	P	D	D	N	T	D	0.746	T	T	T	0.322	.	0.605	0.153	D	T	T	T	D	D	4.005	27.000	0.999	D	D	0.554	5.489	0.573	5.902	1.000	0.497	0.590	0.578	0.563	.	4.580	4.580	7.905	1.026	0.549	0.990	0.977	0.957	531	Zinc_finger_C2H2-type	.	.	.	GLIS1	181	0	263	34	0.114478114478114	TRUE	NA
ENSG00000058799.15	.	BCM	GRCh38.p13	chr1	53871390	53871390	+	C	C	T	Missense_Mutation	SNP	ENST00000072644.7	exon7	c.G463A	p.V155M	exonic	ENSG00000058799.15	.	nonsynonymous SNV	ENSG00000058799.15:ENST00000072644.7:exon7:c.G463A:p.V155M	1p32.3	C3N-02940	8.238e-06	0	0	0	0	1.499e-05	0	0	rs764033322	10.20	T	T	D	D	D	D	M	T	N	0.612	T	T	D	0.105	0.223	0.613	0.224	T	T	T	T	D	D	3.947	26.600	0.998	D	D	0.752	7.906	0.751	8.831	1.000	0.732	0.744	0.710	0.714	.	5.690	5.690	5.921	1.026	0.599	1.000	1.000	0.992	857	Yip1_domain	.	.	.	YIPF1	148	0	229	13	0.0537190082644628	TRUE	NA
ENSG00000134249.7	.	BCM	GRCh38.p13	chr1	119894622	119894622	+	G	G	A	Missense_Mutation	SNP	ENST00000369400.2	exon1	c.C1715T	p.T572M	exonic	ENSG00000134249.7	.	nonsynonymous SNV	ENSG00000134249.7:ENST00000369400.2:exon1:c.C1715T:p.T572M	1p12	C3N-02940	2.474e-05	0	0	0.0001	0	1.5e-05	0	6.057e-05	rs367708640	6.20	D	D	D	P	N	N	M	T	D	0.174	T	T	T	0.119	.	0.409	0.505	T	T	T	T	D	T	2.016	19.380	0.997	N	N	-0.055	2.322	-0.287	1.591	1.000	0.497	0.590	0.547	0.542	.	5.280	3.380	-0.301	1.089	0.676	0.000	0.148	0.085	881	ADAM,_cysteine-rich	.	.	ID=COSV101023996;OCCURENCE=1(prostate)	ADAM30	292	1	457	356	0.437884378843788	TRUE	NA
ENSG00000133019.11	.	BCM	GRCh38.p13	chr1	239907527	239907527	+	G	G	A	Missense_Mutation	SNP	ENST00000255380.8	exon5	c.G76A	p.D26N	exonic	ENSG00000133019.11	.	nonsynonymous SNV	ENSG00000133019.11:ENST00000255380.8:exon5:c.G76A:p.D26N	1q43	C3N-02940	4.952e-05	0	0	0	0	9.011e-05	0	0	rs200014816	0.20	T	T	B	B	N	N	N	T	N	0.160	T	T	T	0.093	0.133	0.383	0.466	T	T	T	T	T	T	1.060	12.350	0.963	N	N	-0.633	0.928	-0.531	1.152	0.004	0.615	0.574	0.659	0.564	.	5.600	3.610	1.625	0.220	-0.120	0.256	0.009	0.428	971	.	.	.	ID=COSV99698054;OCCURENCE=2(skin)	CHRM3	242	0	426	33	0.0718954248366013	TRUE	NA
ENSG00000180432.6	.	BCM	GRCh38.p13	chr3	42874439	42874439	+	G	G	C	Missense_Mutation	SNP	ENST00000316161.6	exon1	c.C1378G	p.H460D	exonic	ENSG00000180432.6	.	nonsynonymous SNV	ENSG00000180432.6:ENST00000316161.6:exon1:c.C1378G:p.H460D	3p22.1	C3N-02940	.	.	.	.	.	.	.	.	.	7.20	T	T	P	B	U	D	L	T	D	0.298	T	T	D	0.145	0.505	0.277	0.244	T	D	T	T	D	T	2.028	19.470	0.969	D	D	-0.358	1.476	-0.422	1.333	0.824	0.497	0.590	0.547	0.542	.	5.150	-1.940	2.251	-0.243	-0.113	0.963	0.910	0.995	657	.	.	.	.	CYP8B1	385	1	618	41	0.0622154779969651	TRUE	TRUE
ENSG00000172046.19	.	BCM	GRCh38.p13	chr3	49117774	49117774	+	C	C	A	Missense_Mutation	SNP	ENST00000398888.6	exon4	c.G355T	p.D119Y	exonic	ENSG00000172046.19	.	nonsynonymous SNV	ENSG00000172046.19:ENST00000398888.6:exon4:c.G355T:p.D119Y	3p21.31	C3N-02940	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.713	T	T	D	0.397	0.620	0.305	0.689	T	T	T	T	D	D	3.689	25.400	0.994	D	D	0.562	5.558	0.549	5.640	1.000	0.719	0.698	0.723	0.636	.	4.770	4.770	4.499	0.947	0.599	0.991	0.996	0.993	0	CS_domain	.	.	.	USP19	222	0	370	25	0.0632911392405063	TRUE	TRUE
ENSG00000187054.15	.	BCM	GRCh38.p13	chr4	67946551	67946551	+	C	C	T	Missense_Mutation	SNP	ENST00000334830.11	exon2	c.G32A	p.R11Q	exonic	ENSG00000187054.15	.	nonsynonymous SNV	ENSG00000187054.15:ENST00000334830.11:exon2:c.G32A:p.R11Q	4q13.2	C3N-02940	.	.	.	.	.	.	.	.	rs1037515820	1.16	T	T	.	.	N	N	.	D	N	0.080	T	T	T	0.240	.	0.427	0.113	T	.	T	T	T	T	-1.073	0.005	0.738	N	N	-2.098	0.006	-2.208	0.005	0.949	0.487	0.574	0.574	0.564	.	4.590	-9.170	-4.109	-3.361	-1.682	0.000	0.000	0.000	789	.	.	.	ID=COSV58356942;OCCURENCE=1(pancreas),1(skin),1(lung)	TMPRSS11A	150	0	270	18	0.0625	TRUE	TRUE
ENSG00000138792.10	.	BCM	GRCh38.p13	chr4	110476783	110476783	+	C	C	G	Missense_Mutation	SNP	ENST00000265162.10	exon1	c.C369G	p.I123M	exonic	ENSG00000138792.10	.	nonsynonymous SNV	ENSG00000138792.10:ENST00000265162.10:exon1:c.C369G:p.I123M	4q25	C3N-02940	.	.	.	.	.	.	.	.	.	4.20	D	D	P	P	N	N	M	T	N	0.342	T	T	T	0.057	0.580	0.198	0.498	T	T	T	T	D	T	2.849	23.100	0.982	N	N	-0.367	1.456	-0.541	1.137	0.992	0.447	0.563	0.492	0.530	.	5.830	3.040	0.044	1.000	-0.214	0.025	0.187	0.173	734	.	.	.	.	ENPEP	596	0	953	63	0.062007874015748	TRUE	TRUE
ENSG00000168843.14	.	BCM	GRCh38.p13	chr4	161386375	161386375	+	G	G	T	Missense_Mutation	SNP	ENST00000306100.10	exon16	c.C1916A	p.T639K	exonic	ENSG00000168843.14	.	nonsynonymous SNV	ENSG00000168843.14:ENST00000306100.10:exon16:c.C1916A:p.T639K	4q32.2	C3N-02940	.	.	.	.	.	.	.	.	.	10.20	D	D	B	B	D	D	M	T	D	0.220	T	T	T	0.232	0.610	0.573	0.377	T	T	T	T	D	D	2.914	23.200	0.994	D	D	0.467	4.789	0.541	5.557	0.506	0.638	0.574	0.574	0.668	.	5.530	5.530	5.822	1.176	0.676	1.000	1.000	0.998	979	.	.	.	ID=COSV60183216;OCCURENCE=1(oesophagus)	FSTL5	197	0	264	38	0.125827814569536	TRUE	TRUE
ENSG00000152034.11	.	BCM	GRCh38.p13	chr6	99934500	99934500	+	G	G	A	Missense_Mutation	SNP	ENST00000281806.7	exon5	c.C605T	p.T202M	exonic	ENSG00000152034.11	.	nonsynonymous SNV	ENSG00000152034.11:ENST00000281806.7:exon5:c.C605T:p.T202M	6q16.2	C3N-02940	.	.	.	.	.	.	.	.	rs376688154	3.20	T	T	B	B	N	D	L	T	N	0.444	T	T	D	0.321	.	0.930	0.162	T	T	T	T	T	T	2.737	22.900	0.983	D	N	0.015	2.566	0.124	2.835	0.993	0.487	0.574	0.547	0.564	.	5.330	4.470	3.127	1.006	0.676	1.000	0.971	0.974	493	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV56009994;OCCURENCE=1(oesophagus),1(prostate),1(lung)	MCHR2	55	0	86	5	0.0549450549450549	TRUE	TRUE
ENSG00000122691.13	.	BCM	GRCh38.p13	chr7	19116954	19116954	+	G	G	A	Missense_Mutation	SNP	ENST00000242261.6	exon1	c.C368T	p.S123L	exonic	ENSG00000122691.13	.	nonsynonymous SNV	ENSG00000122691.13:ENST00000242261.6:exon1:c.C368T:p.S123L	7p21.1	C3N-02940	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.618	D	D	D	0.791	0.458	0.999	2.510	D	D	D	D	D	D	4.483	32	0.998	D	D	0.389	4.277	0.366	4.127	1.000	0.598	0.596	0.504	0.604	.	4.650	3.760	6.727	1.085	0.607	1.000	1.000	0.996	964	Myc-type,_basic_helix-loop-helix_(bHLH)_domain	.	.	.	TWIST1	243	0	335	22	0.061624649859944	TRUE	TRUE
ENSG00000221900.6	.	BCM	GRCh38.p13	chr7	53036107	53036107	+	C	C	T	Missense_Mutation	SNP	ENST00000408890.6	exon1	c.C436T	p.R146C	exonic	ENSG00000221900.6	.	nonsynonymous SNV	ENSG00000221900.6:ENST00000408890.6:exon1:c.C436T:p.R146C	7p12.1	C3N-02940	2.616e-05	0	0	0	0	4.775e-05	0	0	rs761437622	3.19	D	D	P	B	.	N	L	T	D	0.166	T	T	T	0.019	.	0.126	0.093	T	T	T	T	T	T	0.878	10.200	0.985	N	N	-0.739	0.748	-0.921	0.591	0.000	0.487	0.574	0.547	0.564	.	1.950	0.986	-1.598	-0.519	-0.202	0.000	0.000	0.001	981	.	.	.	ID=COSV101374907;OCCURENCE=1(stomach),1(upper_aerodigestive_tract)	POM121L12	373	0	574	38	0.0620915032679739	TRUE	NA
ENSG00000106665.16	.	BCM	GRCh38.p13	chr7	74353952	74353952	+	G	G	A	Missense_Mutation	SNP	ENST00000223398.11	exon4	c.G751A	p.V251M	exonic	ENSG00000106665.16	.	nonsynonymous SNV	ENSG00000106665.16:ENST00000223398.11:exon4:c.G751A:p.V251M	7q11.23	C3N-02940	4.951e-05	0	0	0	0	6.004e-05	0	0.0001	rs535427245	20.20	D	D	D	D	D	D	H	D	D	0.918	D	D	D	0.886	0.706	0.955	1.722	D	D	D	D	D	D	4.196	28.600	0.999	D	D	1.118	18.333	1.024	20.384	1.000	0.707	0.702	0.607	0.714	.	5.500	5.500	9.743	1.176	0.676	1.000	1.000	1.000	911	CAP_Gly-rich_domain	.	.	ID=COSV56281778;OCCURENCE=1(biliary_tract)	CLIP2	178	0	282	15	0.0505050505050505	TRUE	TRUE
ENSG00000197140.15	.	BCM	GRCh38.p13	chr8	39223055	39223055	+	G	G	A	Missense_Mutation	SNP	ENST00000379907.9	exon14	c.G1342A	p.V448I	exonic	ENSG00000197140.15	.	nonsynonymous SNV	ENSG00000197140.15:ENST00000379907.9:exon14:c.G1342A:p.V448I	8p11.22	C3N-02940	0.0004	0.0027	0.0003	0.0003	0	7.917e-05	0	0.0004	rs143711220	0.20	T	T	P	B	N	N	L	T	N	0.159	T	T	T	0.022	.	0.040	0.045	T	T	T	T	T	T	-1.076	0.005	0.617	N	N	-1.875	0.017	-2.085	0.009	1.000	0.554	0.574	0.574	0.621	.	5.550	-11.100	-1.840	-0.783	-0.781	0.000	0.004	0.074	819	Disintegrin,_conserved_site;Disintegrin_domain	.	.	ID=COSV65949246;OCCURENCE=1(large_intestine),1(stomach)	ADAM32	242	0	345	22	0.0599455040871935	TRUE	TRUE
ENSG00000106852.15	.	BCM	GRCh38.p13	chr9	122226476	122226476	+	C	C	T	Missense_Mutation	SNP	ENST00000373755.6	exon3	c.G274A	p.V92M	exonic	ENSG00000106852.15	.	nonsynonymous SNV	ENSG00000106852.15:ENST00000373755.6:exon3:c.G274A:p.V92M	9q33.2	C3N-02940	.	.	.	.	.	.	.	.	.	12.20	D	D	P	B	D	D	L	D	N	0.528	D	D	D	0.408	0.449	0.678	2.582	T	T	T	T	D	D	2.937	23.300	0.998	D	D	0.415	4.437	0.471	4.905	1.000	0.677	0.563	0.607	0.601	.	5.350	5.350	3.715	1.026	0.599	1.000	1.000	1.000	936	Zinc_finger,_LIM-type	.	.	.	LHX6	233	0	324	28	0.0795454545454545	TRUE	NA
ENSG00000148187.18	.	BCM	GRCh38.p13	chr9	122313285	122313285	+	G	G	T	Missense_Mutation	SNP	ENST00000344641.8	exon6	c.G610T	p.A204S	exonic	ENSG00000148187.18	.	nonsynonymous SNV	ENSG00000148187.18:ENST00000344641.8:exon6:c.G610T:p.A204S	9q33.2	C3N-02940	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	D	D	L	T	N	0.217	T	T	T	0.105	0.615	0.690	0.166	T	T	T	T	D	T	3.104	23.600	0.996	D	D	0.355	4.074	0.441	4.665	1.000	0.732	0.725	0.744	0.714	.	5.140	5.140	5.812	1.176	0.676	1.000	1.000	0.998	950	Ribosome_recycling_factor_domain	.	.	.	MRRF	343	0	541	35	0.0607638888888889	TRUE	TRUE
ENSG00000138161.14	.	BCM	GRCh38.p13	chr10	122834910	122834910	+	T	T	C	Missense_Mutation	SNP	ENST00000392790.6	exon7	c.A1178G	p.Y393C	exonic	ENSG00000138161.14	.	nonsynonymous SNV	ENSG00000138161.14:ENST00000392790.6:exon7:c.A1178G:p.Y393C	10q26.13	C3N-02940	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	M	T	D	0.728	D	D	D	0.633	0.805	0.911	0.422	.	D	D	D	D	T	3.278	24.100	0.997	D	N	0.419	4.460	0.315	3.805	0.159	0.732	0.588	0.744	0.528	.	4.810	4.810	1.947	1.138	0.609	0.977	0.992	0.810	950	Zona_pellucida_domain	.	.	.	CUZD1	95	0	124	9	0.0676691729323308	TRUE	TRUE
ENSG00000182022.18	.	BCM	GRCh38.p13	chr10	124042439	124042439	+	G	G	A	Missense_Mutation	SNP	ENST00000435907.6	exon4	c.C895T	p.R299C	exonic	ENSG00000182022.18	.	nonsynonymous SNV	ENSG00000182022.18:ENST00000435907.6:exon4:c.C895T:p.R299C	10q26.13	C3N-02940	8.263e-06	0	0	0	0	0	0	6.118e-05	rs544235718	15.19	D	D	D	D	D	D	M	.	D	0.880	T	T	T	0.673	0.747	0.506	1.099	D	T	D	D	D	D	4.261	29.200	0.999	D	D	0.721	7.419	0.712	7.987	1.000	0.615	0.624	0.659	0.636	.	5.720	5.720	4.813	1.172	0.672	1.000	0.990	0.843	844	.	.	.	.	CHST15	102	0	169	15	0.0815217391304348	TRUE	NA
ENSG00000166341.8	.	BCM	GRCh38.p13	chr11	6621877	6621877	+	C	C	T	Missense_Mutation	SNP	ENST00000299441.5	exon21	c.G9799A	p.V3267I	exonic	ENSG00000166341.8	.	nonsynonymous SNV	ENSG00000166341.8:ENST00000299441.5:exon21:c.G9799A:p.V3267I	11p15.4	C3N-02940	2.014e-05	0.0002	0	0	0	0	0	0	rs530939498	5.20	T	T	D	B	N	D	L	T	N	0.346	T	T	T	0.150	.	0.351	0.357	T	T	T	T	T	D	2.742	22.900	0.988	D	D	0.420	4.467	0.475	4.936	1.000	0.707	0.627	0.723	0.714	.	5.010	5.010	4.162	1.026	0.599	0.993	0.971	0.982	526	.	.	.	ID=COSV100197569;OCCURENCE=1(endometrium)	DCHS1	159	0	185	15	0.075	TRUE	NA
ENSG00000254598.3	.	BCM	GRCh38.p13	chr11	11352324	11352324	+	C	C	T	Missense_Mutation	SNP	ENST00000528848.3	exon1	c.G796A	p.D266N	exonic	ENSG00000254598.3	.	nonsynonymous SNV	ENSG00000254598.3:ENST00000528848.3:exon1:c.G796A:p.D266N	11p15.4	C3N-02940	.	.	.	.	.	.	.	.	.	3.14	.	T	P	P	.	D	N	T	.	0.265	.	.	T	.	.	0.107	0.346	T	T	T	T	.	D	2.717	22.900	0.791	D	N	.	.	.	.	1.000	0.294	0.333	0.293	0.331	.	1.860	1.860	4.010	0.288	0.445	1.000	0.920	0.939	940	Protein_kinase_domain	.	.	.	CSNK2A3	457	0	654	40	0.0576368876080692	NA	TRUE
ENSG00000006071.15	.	BCM	GRCh38.p13	chr11	17393698	17393698	+	G	G	A	Missense_Mutation	SNP	ENST00000389817.8	exon38	c.C4607T	p.A1536V	exonic	ENSG00000006071.15	.	nonsynonymous SNV	ENSG00000006071.15:ENST00000389817.8:exon38:c.C4607T:p.A1536V	11p15.1	C3N-02940	1.648e-05	0	0	0	0	0	0	0.0001	rs745918247	19.20	D	D	D	P	D	D	M	D	D	0.982	D	D	D	0.951	0.822	0.957	1.645	D	D	D	D	D	D	5.087	33	0.999	D	D	0.856	9.978	0.792	9.905	1.000	0.615	0.547	0.659	0.542	.	5.080	5.080	9.310	1.089	0.676	1.000	0.998	0.977	594	ABC_transporter-like;AAA+_ATPase_domain	.	.	ID=COSV56854756;OCCURENCE=1(large_intestine),1(stomach)	ABCC8	599	1	900	60	0.0625	TRUE	TRUE
ENSG00000179817.5	.	BCM	GRCh38.p13	chr11	18174203	18174203	+	C	C	T	Missense_Mutation	SNP	ENST00000314254.3	exon1	c.C947T	p.S316L	exonic	ENSG00000179817.5	.	nonsynonymous SNV	ENSG00000179817.5:ENST00000314254.3:exon1:c.C947T:p.S316L	11p15.1	C3N-02940	.	.	.	.	.	.	.	.	.	4.20	D	D	P	P	N	N	L	T	D	0.081	T	T	T	0.024	0.248	0.506	0.186	T	T	T	T	D	T	1.644	16.660	0.979	N	N	-0.426	1.326	-0.704	0.894	0.005	0.487	0.563	0.574	0.542	.	2.010	1.080	-0.232	-0.203	-0.387	0.000	0.000	0.002	840	.	.	.	ID=COSV58590471;OCCURENCE=1(ovary)	MRGPRX4	134	0	206	13	0.0593607305936073	NA	TRUE
ENSG00000172572.6	.	BCM	GRCh38.p13	chr12	20630103	20630103	+	T	T	C	Missense_Mutation	SNP	ENST00000359062.3	exon6	c.T1736C	p.L579P	exonic	ENSG00000172572.6	.	nonsynonymous SNV	ENSG00000172572.6:ENST00000359062.3:exon6:c.T1736C:p.L579P	12p12.2	C3N-02940	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.380	T	T	T	0.115	0.304	0.189	0.109	T	T	T	T	T	T	1.874	18.290	0.979	N	N	-0.795	0.662	-0.712	0.882	1.000	0.707	0.574	0.659	0.714	.	5.380	1.660	2.519	0.188	0.644	0.108	0.930	0.998	931	.	.	.	.	PDE3A	319	0	432	23	0.0505494505494506	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-02940	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	261	0	427	71	0.142570281124498	TRUE	TRUE
ENSG00000123360.12	.	BCM	GRCh38.p13	chr12	54576638	54576638	+	C	C	T	Missense_Mutation	SNP	ENST00000243052.8	exon14	c.C1444T	p.R482C	exonic	ENSG00000123360.12	.	nonsynonymous SNV	ENSG00000123360.12:ENST00000243052.8:exon14:c.C1444T:p.R482C	12q13.2	C3N-02940	8.363e-06	0	0	0.0001	0	0	0	0	rs764032346	13.20	D	D	D	D	D	D	L	T	D	0.600	T	T	D	0.536	0.475	0.508	1.095	T	T	T	D	D	D	3.654	25.200	0.999	D	D	0.553	5.472	0.563	5.785	1.000	0.707	0.725	0.602	0.542	.	4.860	4.860	3.339	1.026	0.599	1.000	0.826	0.171	686	3'5'-cyclic_nucleotide_phosphodiesterase,_catalytic_domain	.	.	ID=COSV54495233;OCCURENCE=2(skin)	PDE1B	361	0	524	42	0.0742049469964664	TRUE	TRUE
ENSG00000089250.19	.	BCM	GRCh38.p13	chr12	117243336	117243336	+	G	G	A	Missense_Mutation	SNP	ENST00000317775.11	exon19	c.C2923T	p.R975C	exonic	ENSG00000089250.19	.	nonsynonymous SNV	ENSG00000089250.19:ENST00000317775.11:exon19:c.C2923T:p.R975C	12q24.22	C3N-02940	2.485e-05	0.0001	0	0.0001	0	1.499e-05	0	0	rs771520384	15.20	D	D	D	D	D	D	M	T	D	0.712	T	T	D	0.679	0.621	0.742	1.624	T	D	T	D	D	D	4.465	32	0.999	D	D	0.661	6.611	0.573	5.902	1.000	0.615	0.574	0.659	0.564	.	3.590	3.590	7.339	1.163	0.618	1.000	1.000	0.999	921	.	.	.	ID=COSV100499775;OCCURENCE=1(large_intestine)	NOS1	189	0	299	22	0.0685358255451713	TRUE	NA
ENSG00000133980.5	.	BCM	GRCh38.p13	chr14	74358219	74358219	+	C	C	T	Missense_Mutation	SNP	ENST00000256362.5	exon2	c.C1436T	p.A479V	exonic	ENSG00000133980.5	.	nonsynonymous SNV	ENSG00000133980.5:ENST00000256362.5:exon2:c.C1436T:p.A479V	14q24.3	C3N-02940	6.804e-05	0.0001	0.0004	0.0001	0	1.559e-05	0	0	rs756291711	0.20	T	T	B	B	N	N	N	T	N	0.005	T	T	T	0.027	0.108	0.043	0.432	T	T	T	T	T	T	-2.010	0.001	0.649	N	N	-2.021	0.008	-2.112	0.008	1.000	0.722	0.590	0.699	0.542	.	4.290	-8.570	-2.065	-1.561	-2.150	0.000	0.000	0.000	269	.	.	.	ID=COSV56439091;OCCURENCE=1(biliary_tract),1(ovary)	VRTN	76	0	107	9	0.0775862068965517	TRUE	NA
ENSG00000156414.19	.	BCM	GRCh38.p13	chr14	103928657	103928657	+	G	G	A	Missense_Mutation	SNP	ENST00000409874.9	exon1	c.G148A	p.A50T	exonic	ENSG00000156414.19	.	nonsynonymous SNV	ENSG00000156414.19:ENST00000409874.9:exon1:c.G148A:p.A50T	14q32.33	C3N-02940	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.055	T	T	T	0.006	0.212	0.014	0.205	T	T	T	T	T	T	-0.100	0.829	0.850	N	N	-1.812	0.022	-1.922	0.020	1.000	0.554	0.588	0.578	0.605	.	4.070	-8.150	-1.312	-0.974	0.609	0.000	0.000	0.003	446	.	.	.	.	TDRD9	43	0	71	7	0.0897435897435897	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674893	7674893	+	C	C	A	Missense_Mutation	SNP	ENST00000269305.8	exon6	c.G638T	p.R213L	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon6:c.G638T:p.R213L	17p13.1	C3N-02940	.	.	.	.	.	.	.	.	rs587778720	19.20	D	D	D	D	D	D	M	D	D	0.964	D	D	D	0.929	0.930	0.995	1.850	T	D	D	D	D	D	4.252	29.100	0.998	D	D	0.690	6.986	0.553	5.678	0.999	0.722	0.698	0.702	0.735	.	5.280	4.320	7.905	1.026	0.599	0.954	0.996	0.998	433	p53,_DNA-binding_domain	.	.	ID=COSV52668963;OCCURENCE=3(breast),12(liver),4(oesophagus),1(adrenal_gland),14(large_intestine),2(central_nervous_system),3(ovary),2(stomach),3(haematopoietic_and_lymphoid_tissue),1(kidney),1(soft_tissue),6(urinary_tract),8(pancreas),3(prostate),10(lung),1(thyroid),9(upper_aerodigestive_tract),1(eye)	TP53	395	0	485	90	0.156521739130435	TRUE	TRUE
ENSG00000141161.11	.	BCM	GRCh38.p13	chr17	35150167	35150167	+	C	C	T	Missense_Mutation	SNP	ENST00000268876.9	exon4	c.C325T	p.R109W	exonic	ENSG00000141161.11	.	nonsynonymous SNV	ENSG00000141161.11:ENST00000268876.9:exon4:c.C325T:p.R109W	17q12	C3N-02940	3.311e-05	0	0	0.0002	0	1.504e-05	0	6.173e-05	rs774414887	9.20	D	D	D	D	N	N	L	T	D	0.333	T	T	D	0.167	.	0.770	0.102	T	T	T	T	T	D	3.499	24.700	0.999	D	D	0.029	2.616	-0.039	2.232	1.000	0.497	0.547	0.547	0.542	.	4.550	-1.540	1.099	-0.308	0.599	0.787	0.660	0.982	912	Tetratricopeptide_repeat-containing_domain	.	.	ID=COSV52098827;OCCURENCE=1(large_intestine)	UNC45B	143	0	252	15	0.0561797752808989	TRUE	TRUE
ENSG00000105559.12	.	BCM	GRCh38.p13	chr19	48859093	48859093	+	G	G	A	Missense_Mutation	SNP	ENST00000263265.11	exon8	c.C739T	p.R247C	exonic	ENSG00000105559.12	.	nonsynonymous SNV	ENSG00000105559.12:ENST00000263265.11:exon8:c.C739T:p.R247C	19q13.33	C3N-02940	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	N	D	M	T	D	0.596	T	T	T	0.127	0.375	0.650	0.971	D	T	T	T	D	D	4.504	32	0.999	D	D	0.288	3.716	0.238	3.377	1.000	0.617	0.749	0.786	0.605	.	4.780	3.730	4.595	1.101	0.590	0.998	0.912	0.642	749	.	.	.	.	PLEKHA4	77	0	124	8	0.0606060606060606	TRUE	NA
ENSG00000125787.11	.	BCM	GRCh38.p13	chr20	3044521	3044521	+	G	G	A	Missense_Mutation	SNP	ENST00000245983.6	exon2	c.G107A	p.R36Q	exonic	ENSG00000125787.11	.	nonsynonymous SNV	ENSG00000125787.11:ENST00000245983.6:exon2:c.G107A:p.R36Q	20p13	C3N-02940	2.485e-05	9.681e-05	8.675e-05	0	0	1.508e-05	0	0	rs61729221	4.19	D	D	P	B	.	N	L	T	D	0.283	T	T	T	0.061	.	0.381	0.047	T	D	T	T	T	T	0.265	3.883	0.925	N	N	-0.823	0.622	-0.894	0.628	1.000	0.421	0.551	0.514	0.646	.	4.270	-0.102	0.665	-1.493	-0.292	0.736	0.002	0.044	830	.	.	.	ID=COSV55661492;OCCURENCE=1(stomach)	GNRH2	234	0	354	45	0.112781954887218	TRUE	TRUE
ENSG00000088827.12	.	BCM	GRCh38.p13	chr20	3697268	3697268	+	G	G	A	Missense_Mutation	SNP	ENST00000344754.5	exon9	c.C2197T	p.R733W	exonic	ENSG00000088827.12	.	nonsynonymous SNV	ENSG00000088827.12:ENST00000344754.5:exon9:c.C2197T:p.R733W	20p13	C3N-02940	5.809e-05	0.0002	0	0.0001	0	6.052e-05	0	0	rs142675072	4.20	D	D	D	P	N	N	M	T	N	0.509	T	T	T	0.141	.	0.613	0.502	T	T	T	T	T	T	2.982	23.400	0.999	N	N	-0.031	2.403	-0.178	1.840	0.005	0.487	0.574	0.578	0.563	.	5.310	4.330	0.813	0.219	0.662	0.001	0.004	0.455	735	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	SIGLEC1	498	1	740	43	0.0549169859514687	TRUE	NA
ENSG00000124212.6	.	BCM	GRCh38.p13	chr20	49511079	49511079	+	G	G	A	Missense_Mutation	SNP	ENST00000244043.5	exon9	c.C1307T	p.A436V	exonic	ENSG00000124212.6	.	nonsynonymous SNV	ENSG00000124212.6:ENST00000244043.5:exon9:c.C1307T:p.A436V	20q13.13	C3N-02940	1.651e-05	0	0	0	0	1.501e-05	0	6.066e-05	rs267605985	15.20	D	D	D	D	D	D	M	T	D	0.651	T	T	D	0.605	0.808	0.896	0.381	T	T	D	D	D	D	3.611	25.100	0.999	D	D	0.564	5.577	0.492	5.089	1.000	0.706	0.590	0.710	0.580	.	5.260	5.260	6.465	1.176	0.671	1.000	0.016	0.810	420	.	.	.	.	PTGIS	294	0	421	33	0.0726872246696035	TRUE	NA
ENSG00000165195.15	.	BCM	GRCh38.p13	chrX	15324857	15324857	+	T	T	G	Missense_Mutation	SNP	ENST00000333590.5	exon5	c.A996C	p.R332S	exonic	ENSG00000165195.15	.	nonsynonymous SNV	ENSG00000165195.15:ENST00000333590.5:exon5:c.A996C:p.R332S	Xp22.2	C3N-02940	.	.	.	.	.	.	.	.	.	9.19	T	T	B	B	D	D	L	T	D	0.573	T	T	D	0.507	0.485	0.785	0.652	T	D	D	T	D	D	1.806	17.780	0.975	D	.	.	.	.	.	0.995	.	.	.	.	.	5.690	3.840	1.612	0.104	-0.218	1.000	0.973	0.964	111	Glycosyl_transferase,_family_1	.	.	.	PIGA	72	0	112	9	0.0743801652892562	TRUE	TRUE
ENSG00000169083.17	.	BCM	GRCh38.p13	chrX	67545771	67545771	+	G	G	A	Missense_Mutation	SNP	ENST00000374690.9	exon1	c.G625A	p.G209R	exonic	ENSG00000169083.17	.	nonsynonymous SNV	ENSG00000169083.17:ENST00000374690.9:exon1:c.G625A:p.G209R	Xq12	C3N-02940	1.306e-05	0	0	0	0	2.389e-05	0	0	rs775392428	7.16	D	T	.	.	N	N	.	D	D	0.453	D	D	D	0.293	.	0.976	1.245	T	T	T	T	T	D	2.702	22.800	0.982	N	.	.	.	.	.	1.000	.	.	.	.	.	5.150	2.230	1.557	1.164	0.660	0.742	0.872	0.875	563	.	.	.	.	AR	106	0	140	12	0.0789473684210526	TRUE	NA
ENSG00000130224.15	.	BCM	GRCh38.p13	chrX	115123085	115123085	+	G	G	A	Missense_Mutation	SNP	ENST00000317135.13	exon18	c.C1957T	p.R653C	exonic	ENSG00000130224.15	.	nonsynonymous SNV	ENSG00000130224.15:ENST00000317135.13:exon18:c.C1957T:p.R653C	Xq23	C3N-02940	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	M	T	D	0.815	T	T	D	0.382	0.757	0.373	1.541	D	D	T	T	D	D	3.759	25.700	0.999	D	.	.	.	.	.	0.999	.	.	.	.	.	5.310	5.310	6.124	1.172	0.614	1.000	0.977	0.659	937	Calponin_homology_domain	.	.	ID=COSV57747909;OCCURENCE=1(breast),1(large_intestine),1(stomach),1(skin),4(endometrium)	LRCH2	75	0	92	9	0.0891089108910891	TRUE	TRUE
ENSG00000204019.5	.	BCM	GRCh38.p13	chrX	116461755	116461755	+	G	G	A	Missense_Mutation	SNP	ENST00000371894.5	exon2	c.C328T	p.R110W	exonic	ENSG00000204019.5	.	nonsynonymous SNV	ENSG00000204019.5:ENST00000371894.5:exon2:c.C328T:p.R110W	Xq23	C3N-02940	.	.	.	.	.	.	.	.	.	1.17	T	T	B	B	N	N	N	.	D	0.076	T	T	T	0.137	0.188	0.014	0.007	.	T	T	T	T	T	-0.033	1.142	0.888	N	.	.	.	.	.	1.000	.	.	.	.	.	5.140	-6.560	-1.451	-0.842	-0.324	0.000	0.005	0.011	949	.	.	.	.	CT83	63	0	90	19	0.174311926605505	TRUE	TRUE
ENSG00000279804.2	.	BCM	GRCh38.p13	chr1	13225301	13225301	+	C	C	T	Silent	SNP	ENST00000624297.2	exon2	c.G420A	p.R140R	exonic	ENSG00000279804.2	.	synonymous SNV	ENSG00000279804.2:ENST00000624297.2:exon2:c.G420A:p.R140R	1p36.21	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRAMEF18	710	0	749	55	0.068407960199005	NA	TRUE
ENSG00000153820.13	.	BCM	GRCh38.p13	chr2	228019153	228019153	+	G	G	A	Silent	SNP	ENST00000392056.8	exon7	c.C1701T	p.A567A	exonic	ENSG00000153820.13	.	synonymous SNV	ENSG00000153820.13:ENST00000392056.8:exon7:c.C1701T:p.A567A	2q36.3	C3N-02940	0.0001	0.0002	8.645e-05	0	0	0.0001	0	0.0002	rs371211421	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPHKAP	298	0	457	37	0.0748987854251012	TRUE	NA
ENSG00000218336.9	.	BCM	GRCh38.p13	chr4	182738543	182738543	+	C	C	T	Silent	SNP	ENST00000511685.6	exon18	c.C3378T	p.N1126N	exonic	ENSG00000218336.9	.	synonymous SNV	ENSG00000218336.9:ENST00000511685.6:exon18:c.C3378T:p.N1126N	4q35.1	C3N-02940	3.352e-05	0	0	0	0	6.036e-05	0	0	rs757218648	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TENM3	78	0	163	18	0.0994475138121547	TRUE	NA
ENSG00000112992.18	.	BCM	GRCh38.p13	chr5	43656030	43656030	+	C	C	T	Silent	SNP	ENST00000344920.9	exon15	c.C2250T	p.G750G	exonic	ENSG00000112992.18	.	synonymous SNV	ENSG00000112992.18:ENST00000344920.9:exon15:c.C2250T:p.G750G	5p12	C3N-02940	5.772e-05	0	0	0	0	0	0	0.0004	rs748327925	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NNT	279	0	440	39	0.081419624217119	TRUE	NA
ENSG00000145832.14	.	BCM	GRCh38.p13	chr5	135880063	135880063	+	C	C	T	Silent	SNP	ENST00000433282.6	exon7	c.C909T	p.R303R	exonic	ENSG00000145832.14	.	synonymous SNV	ENSG00000145832.14:ENST00000433282.6:exon7:c.C909T:p.R303R	5q31.1	C3N-02940	6.995e-05	0	0	0	0	0	0.0055	0	rs780395889	1.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	0.568	7.202	0.809	N	N	.	.	.	.	1.000	0.554	0.590	0.602	0.542	.	5.830	-8.330	-0.565	-1.522	-0.780	0.065	0.056	0.742	766	.	.	.	.	SLC25A48	203	0	306	18	0.0555555555555556	TRUE	NA
ENSG00000087116.16	.	BCM	GRCh38.p13	chr5	179113945	179113945	+	G	G	A	Silent	SNP	ENST00000251582.12	exon22	c.C3558T	p.P1186P	exonic	ENSG00000087116.16	.	synonymous SNV	ENSG00000087116.16:ENST00000251582.12:exon22:c.C3558T:p.P1186P	5q35.3	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAMTS2	388	0	575	59	0.0930599369085174	TRUE	TRUE
ENSG00000230873.9	.	BCM	GRCh38.p13	chr6	17130809	17130809	+	C	C	T	Silent	SNP	ENST00000536551.6	exon5	c.C759T	p.N253N	exonic	ENSG00000230873.9	.	synonymous SNV	ENSG00000230873.9:ENST00000536551.6:exon5:c.C759T:p.N253N	6p22.3	C3N-02940	0.0002	0	0	0	0	0.0003	0	0.0001	rs760258726	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STMND1	96	0	162	12	0.0689655172413793	TRUE	NA
ENSG00000169894.18	.	BCM	GRCh38.p13	chr7	100959561	100959561	+	T	T	C	Silent	SNP	ENST00000379458.9	exon2	c.T7782C	p.P2594P	exonic	ENSG00000169894.18	.	synonymous SNV	ENSG00000169894.18:ENST00000379458.9:exon2:c.T7782C:p.P2594P	7q22.1	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC3A	51	0	75	4	0.0506329113924051	TRUE	NA
ENSG00000187122.17	.	BCM	GRCh38.p13	chr10	97060768	97060768	+	G	G	A	Silent	SNP	ENST00000266058.9	exon9	c.C813T	p.R271R	exonic	ENSG00000187122.17	.	synonymous SNV	ENSG00000187122.17:ENST00000266058.9:exon9:c.C813T:p.R271R	10q24.1	C3N-02940	2.136e-05	0	0	0	0	0	0	0.0002	rs774778879	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56586381;OCCURENCE=1(large_intestine)	SLIT1	137	0	262	20	0.0709219858156028	TRUE	TRUE
ENSG00000182791.5	.	BCM	GRCh38.p13	chr11	66590676	66590676	+	C	C	T	Silent	SNP	ENST00000333861.5	exon1	c.G2340A	p.E780E	exonic	ENSG00000182791.5	.	synonymous SNV	ENSG00000182791.5:ENST00000333861.5:exon1:c.G2340A:p.E780E	11q13.2	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC87	215	0	359	23	0.0602094240837696	TRUE	TRUE
ENSG00000077498.9	.	BCM	GRCh38.p13	chr11	89178190	89178190	+	G	G	A	Silent	SNP	ENST00000263321.6	exon1	c.G237A	p.S79S	exonic	ENSG00000077498.9	.	synonymous SNV	ENSG00000077498.9:ENST00000263321.6:exon1:c.G237A:p.S79S	11q14.3	C3N-02940	1.655e-05	9.639e-05	0	0.0001	0	0	0	0	rs376813190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54469844;OCCURENCE=2(large_intestine),1(central_nervous_system),3(urinary_tract)	TYR	502	0	620	41	0.0620272314674735	TRUE	TRUE
ENSG00000136111.14	.	BCM	GRCh38.p13	chr13	75312766	75312766	+	G	G	A	Silent	SNP	ENST00000377636.8	exon13	c.C2355T	p.N785N	exonic	ENSG00000136111.14	.	synonymous SNV	ENSG00000136111.14:ENST00000377636.8:exon13:c.C2355T:p.N785N	13q22.2	C3N-02940	8.282e-06	0.0001	0	0	0	0	0	0	rs527354382	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBC1D4	270	0	387	49	0.112385321100917	TRUE	NA
ENSG00000197102.12	.	BCM	GRCh38.p13	chr14	102027816	102027816	+	A	A	G	Silent	SNP	ENST00000360184.10	exon47	c.A9246G	p.S3082S	exonic	ENSG00000197102.12	.	synonymous SNV	ENSG00000197102.12:ENST00000360184.10:exon47:c.A9246G:p.S3082S	14q32.31	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DYNC1H1	698	0	1051	71	0.0632798573975045	TRUE	TRUE
ENSG00000130479.11	.	BCM	GRCh38.p13	chr19	17726353	17726353	+	C	C	T	Silent	SNP	ENST00000324096.9	exon5	c.C969T	p.D323D	exonic	ENSG00000130479.11	.	synonymous SNV	ENSG00000130479.11:ENST00000324096.9:exon5:c.C969T:p.D323D	19p13.11	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP1S	400	0	540	35	0.0608695652173913	TRUE	TRUE
ENSG00000196218.13	.	BCM	GRCh38.p13	chr19	38458189	38458189	+	C	C	T	Silent	SNP	ENST00000359596.8	exon18	c.C2064T	p.T688T	exonic	ENSG00000196218.13	.	synonymous SNV	ENSG00000196218.13:ENST00000359596.8:exon18:c.C2064T:p.T688T	19q13.2	C3N-02940	8.341e-06	0	0	0.0001	0	0	0	0	rs764993324	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62097525;OCCURENCE=1(lung)	RYR1	387	0	466	268	0.365122615803815	TRUE	TRUE
ENSG00000198300.14	.	BCM	GRCh38.p13	chr19	56815262	56815262	+	G	G	A	Silent	SNP	ENST00000326441.15	exon10	c.C3180T	p.G1060G	exonic	ENSG00000198300.14	.	synonymous SNV	ENSG00000198300.14:ENST00000326441.15:exon10:c.C3180T:p.G1060G	19q13.43	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55651259;OCCURENCE=1(pancreas)	PEG3	125	0	221	13	0.0555555555555556	TRUE	TRUE
ENSG00000196236.13	.	BCM	GRCh38.p13	chr22	40914307	40914307	+	G	G	A	Silent	SNP	ENST00000357137.9	exon7	c.G1038A	p.T346T	exonic	ENSG00000196236.13	.	synonymous SNV	ENSG00000196236.13:ENST00000357137.9:exon7:c.G1038A:p.T346T	22q13.2	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63210168;OCCURENCE=1(stomach)	XPNPEP3	514	0	773	131	0.144911504424779	TRUE	TRUE
ENSG00000102081.15	.	BCM	GRCh38.p13	chrX	147928712	147928712	+	A	A	C	Silent	SNP	ENST00000370475.9	exon5	c.A324C	p.T108T	exonic	ENSG00000102081.15	.	synonymous SNV	ENSG00000102081.15:ENST00000370475.9:exon5:c.A324C:p.T108T	Xq27.3	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FMR1	89	0	114	22	0.161764705882353	TRUE	TRUE
ENSG00000157168.20	.	BCM	GRCh38.p13	chr8	32749575	32749575	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000157168.20	.	.	.	8p12	C3N-02940	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	.	D	.	.	.	0.810	.	.	.	.	.	.	.	.	.	D	D	.	.	9.214	48	0.996	D	N	1.257	30.294	1.121	29.653	1.000	0.615	0.574	0.547	0.655	.	5.590	5.590	9.902	1.176	0.676	1.000	1.000	1.000	844	.	.	.	.	NRG1	160	1	228	24	0.0952380952380952	TRUE	TRUE
ENSG00000254872.3	.	BCM	GRCh38.p13	chr11	1078486	1078486	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000254872.3;ENSG00000198788.8	dist=22737;dist=23969	.	.	11p15.5	C3N-02940	0	0	0	0	0	0	0	0	rs780476801	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC02688	333	1	439	69	0.135826771653543	TRUE	NA
ENSG00000151067.22	.	BCM	GRCh38.p13	chr12	2504537	2504537	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000151067.22	.	.	.	12p13.33	C3N-02940	8.317e-06	0	0	0	0	0	0	6.061e-05	rs751480224	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100216745;OCCURENCE=1(large_intestine),2(lung)	CACNA1C	184	2	292	20	0.0641025641025641	TRUE	NA
ENSG00000090238.12	.	BCM	GRCh38.p13	chr16	30095395	30095395	+	C	C	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000090238.12	ENST00000398838.8:c.-27G>T	.	.	16p11.2	C3N-02940	0.0102	0.0013	0.0059	0	0.0089	0.0156	0.0026	0.0025	rs184524218	2.15	T	T	B	B	N	D	.	.	N	0.065	T	T	.	0.075	.	0.336	0.673	.	.	T	T	T	T	2.012	19.350	0.979	D	N	-0.259	1.716	-0.129	1.965	1.000	0.545	0.522	0.602	0.665	.	3.520	3.520	1.511	1.022	0.596	1.000	1.000	0.999	100	.	0.000	Skin_Not_Sun_Exposed_Suprapubic;Adipose_Subcutaneous;Lung;Skin_Sun_Exposed_Lower_leg	ID=COSV54223198;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(lung)	YPEL3	86	0	133	10	0.0699300699300699	TRUE	TRUE
ENSG00000153885.14	.	BCM	GRCh38.p13	chr19	33813219	33813219	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000153885.14	ENST00000430256.3:c.*271C>T	.	.	19q13.11	C3N-02940	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCTD15	60	0	81	5	0.0581395348837209	TRUE	NA
ENSG00000175497.17	.	BCM	GRCh38.p13	chr2	115836529	115836529	+	C	C	A	Nonsense_Mutation	SNP	ENST00000410059.6	exon23	c.C2073A	p.Y691X	exonic	ENSG00000175497.17	.	stopgain	ENSG00000175497.17:ENST00000410059.6:exon23:c.C2073A:p.Y691X	2q14.1	C3L-04080	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.938	.	.	.	.	.	.	.	.	.	D	D	.	.	7.284	37	0.994	D	N	0.423	4.490	0.224	3.302	0.000	0.638	0.574	0.653	0.564	.	5.280	0.117	0.063	1.026	0.599	0.961	0.996	0.978	903	Peptidase_S9,_prolyl_oligopeptidase,_catalytic_domain	.	.	.	DPP10	169	1	171	70	0.29045643153527	TRUE	TRUE
ENSG00000144229.12	.	BCM	GRCh38.p13	chr2	136882222	136882222	+	G	G	A	Missense_Mutation	SNP	ENST00000409968.6	exon2	c.G44A	p.R15K	exonic	ENSG00000144229.12	.	nonsynonymous SNV	ENSG00000144229.12:ENST00000409968.6:exon2:c.G44A:p.R15K	2q22.1	C3L-04080	.	.	.	.	.	.	.	.	.	1.16	T	T	.	.	U	N	.	T	N	0.215	T	T	T	0.054	0.430	0.105	0.140	.	T	T	T	T	T	1.708	17.080	0.307	D	N	0.021	2.586	0.041	2.505	0.000	0.554	0.574	0.602	0.564	.	5.340	4.260	3.585	1.176	0.676	1.000	0.081	0.186	658	.	.	.	.	THSD7B	140	0	132	40	0.232558139534884	TRUE	TRUE
ENSG00000115145.10	.	BCM	GRCh38.p13	chr2	152175610	152175610	+	T	T	G	Missense_Mutation	SNP	ENST00000263904.5	exon1	c.A33C	p.Q11H	exonic	ENSG00000115145.10	.	nonsynonymous SNV	ENSG00000115145.10:ENST00000263904.5:exon1:c.A33C:p.Q11H	2q23.3	C3L-04080	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	M	T	D	0.330	T	T	T	0.136	0.444	0.307	0.042	T	T	T	T	D	T	1.275	14.210	0.976	N	N	-0.547	1.086	-0.531	1.152	1.000	0.442	0.093	0.522	0.562	.	4.810	-2.980	-0.924	-0.031	0.651	0.680	0.983	0.999	693	VHS_domain	.	.	ID=COSV55731296;OCCURENCE=2(liver)	STAM2	252	1	484	54	0.100371747211896	TRUE	TRUE
ENSG00000056097.16	.	BCM	GRCh38.p13	chr5	32444281	32444281	+	A	A	C	Missense_Mutation	SNP	ENST00000265069.13	exon2	c.T85G	p.F29V	exonic	ENSG00000056097.16	.	nonsynonymous SNV	ENSG00000056097.16:ENST00000265069.13:exon2:c.T85G:p.F29V	5p13.3	C3L-04080	.	.	.	.	.	.	.	.	.	11.20	D	D	B	B	D	D	L	T	D	0.561	T	T	D	0.302	0.660	0.335	2.473	D	T	T	T	D	D	3.352	24.300	0.984	D	D	-0.064	2.290	0.080	2.655	1.000	0.733	0.522	0.601	0.373	.	4.030	4.030	6.513	1.167	0.584	1.000	1.000	0.999	680	.	.	.	.	ZFR	275	0	365	58	0.137115839243499	TRUE	TRUE
ENSG00000047188.16	.	BCM	GRCh38.p13	chr5	113542373	113542373	+	A	A	T	Missense_Mutation	SNP	ENST00000161863.9	exon10	c.A1365T	p.E455D	exonic	ENSG00000047188.16	.	nonsynonymous SNV	ENSG00000047188.16:ENST00000161863.9:exon10:c.A1365T:p.E455D	5q22.2	C3L-04080	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	L	T	N	0.748	T	T	T	0.163	0.388	0.174	0.331	T	T	T	T	D	D	1.823	17.900	0.986	D	N	-0.414	1.353	-0.271	1.626	0.021	0.732	0.744	0.744	0.728	.	5.140	2.680	0.903	1.311	0.754	1.000	1.000	0.987	902	.	.	.	.	YTHDC2	139	0	191	34	0.151111111111111	TRUE	TRUE
ENSG00000164916.11	.	BCM	GRCh38.p13	chr7	4762217	4762217	+	A	A	-	Frame_Shift_Del	DEL	ENST00000328914.5	exon9	c.1955delA	p.A653Rfs*62	exonic	ENSG00000164916.11	.	frameshift deletion	ENSG00000164916.11:ENST00000328914.5:exon9:c.1955delA:p.A653Rfs*62	7p22.1	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FOXK1	206	0	291	36	0.110091743119266	TRUE	TRUE
ENSG00000158683.8	.	BCM	GRCh38.p13	chr7	47929294	47929294	+	T	T	A	Missense_Mutation	SNP	ENST00000289672.6	exon7	c.A970T	p.M324L	exonic	ENSG00000158683.8	.	nonsynonymous SNV	ENSG00000158683.8:ENST00000289672.6:exon7:c.A970T:p.M324L	7p12.3	C3L-04080	.	.	.	.	.	.	.	.	rs944419000	0.20	T	T	B	B	N	N	L	T	N	0.085	T	T	T	0.029	0.513	0.110	0.086	T	T	T	T	T	T	-1.178	0.003	0.727	N	N	-1.913	0.014	-1.997	0.014	1.000	0.615	0.541	0.547	0.655	.	3.970	-7.930	-2.692	-0.875	-0.194	0.000	0.000	0.002	830	.	.	.	.	PKD1L1	270	0	390	60	0.133333333333333	TRUE	NA
ENSG00000147586.10	.	BCM	GRCh38.p13	chr8	80030041	80030041	+	G	G	T	Missense_Mutation	SNP	ENST00000276585.9	exon1	c.C208A	p.Q70K	exonic	ENSG00000147586.10	.	nonsynonymous SNV	ENSG00000147586.10:ENST00000276585.9:exon1:c.C208A:p.Q70K	8q21.13	C3L-04080	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	U	D	N	T	N	0.282	T	T	T	0.074	0.160	0.437	0.157	T	T	T	T	T	T	1.439	15.340	0.947	N	N	-0.713	0.791	-0.596	1.052	1.000	0.442	0.522	0.504	0.562	.	4.580	2.440	3.010	1.075	0.676	0.968	0.127	0.059	922	.	.	.	.	MRPS28	148	0	262	27	0.0934256055363322	TRUE	TRUE
ENSG00000120526.11	.	BCM	GRCh38.p13	chr8	109271015	109271015	+	G	G	A	Missense_Mutation	SNP	ENST00000239690.9	exon8	c.C1289T	p.T430I	exonic	ENSG00000120526.11	.	nonsynonymous SNV	ENSG00000120526.11:ENST00000239690.9:exon8:c.C1289T:p.T430I	8q23.1	C3L-04080	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	N	N	T	N	0.093	T	T	T	0.186	0.342	0.189	0.118	T	T	T	T	D	T	2.453	22.300	0.799	D	D	-0.445	1.288	-0.230	1.715	0.990	0.732	0.725	0.710	0.728	.	6.000	5.130	6.100	1.175	0.669	1.000	0.999	0.972	672	.	.	.	.	NUDCD1	62	0	81	32	0.283185840707965	TRUE	TRUE
ENSG00000122696.14	.	BCM	GRCh38.p13	chr9	37888318	37888318	+	C	C	T	Missense_Mutation	SNP	ENST00000242275.7	exon3	c.G233A	p.R78Q	exonic	ENSG00000122696.14	.	nonsynonymous SNV	ENSG00000122696.14:ENST00000242275.7:exon3:c.G233A:p.R78Q	9p13.2	C3L-04080	1.647e-05	0	0	0.0001	0	1.498e-05	0	0	rs769274693	5.19	T	T	B	B	N	D	.	T	N	0.361	T	T	T	0.516	0.586	0.665	1.174	T	T	T	D	T	D	2.323	21.700	0.999	D	D	0.144	3.065	0.251	3.446	1.000	0.707	0.725	0.609	0.714	.	4.940	4.940	4.670	1.022	0.545	1.000	0.997	0.895	558	.	.	.	ID=COSV54252107;OCCURENCE=1(endometrium)	SLC25A51	275	0	304	32	0.0952380952380952	NA	TRUE
ENSG00000157653.11	.	BCM	GRCh38.p13	chr9	113424285	113424285	+	T	T	A	Missense_Mutation	SNP	ENST00000288462.4	exon8	c.T776A	p.M259K	exonic	ENSG00000157653.11	.	nonsynonymous SNV	ENSG00000157653.11:ENST00000288462.4:exon8:c.T776A:p.M259K	9q32	C3L-04080	.	.	.	.	.	.	.	.	.	11.19	D	T	D	D	D	D	L	T	D	0.929	T	T	D	0.321	0.309	0.667	0.587	.	T	D	D	D	T	3.180	23.800	0.985	D	N	0.423	4.488	0.391	4.296	0.966	0.549	0.588	0.547	0.616	.	4.330	4.330	2.952	1.138	0.665	1.000	0.408	0.692	803	.	.	.	.	C9orf43	100	0	143	44	0.235294117647059	TRUE	TRUE
ENSG00000177963.14	.	BCM	GRCh38.p13	chr11	209587	209587	+	G	G	A	Missense_Mutation	SNP	ENST00000526104.5	exon3	c.G313A	p.V105I	exonic	ENSG00000177963.14	.	nonsynonymous SNV	ENSG00000177963.14:ENST00000526104.5:exon3:c.G313A:p.V105I	11p15.5	C3L-04080	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	.	N	0.094	T	T	T	0.022	0.376	0.437	0.208	T	T	T	T	T	T	0.170	2.786	0.559	N	N	-1.162	0.255	-1.102	0.374	1.000	0.628	0.522	0.672	0.639	.	4.560	2.570	0.163	-0.102	-0.103	0.000	0.000	0.000	774	.	.	.	.	RIC8A	253	0	335	60	0.151898734177215	TRUE	TRUE
ENSG00000174885.12	.	BCM	GRCh38.p13	chr11	281835	281835	+	G	G	A	Missense_Mutation	SNP	ENST00000312165.5	exon4	c.G2101A	p.G701S	exonic	ENSG00000174885.12	.	nonsynonymous SNV	ENSG00000174885.12:ENST00000312165.5:exon4:c.G2101A:p.G701S	11p15.5	C3L-04080	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	.	T	N	0.151	T	T	T	0.121	0.421	0.014	.	T	T	T	T	T	T	0.810	9.492	0.314	N	N	-1.637	0.047	-1.640	0.064	1.000	0.598	0.563	0.578	0.639	.	2.080	-2.010	0.082	-0.154	-0.556	0.493	0.130	0.302	884	.	.	.	.	NLRP6	78	0	100	15	0.130434782608696	TRUE	NA
ENSG00000215182.8	.	BCM	GRCh38.p13	chr11	1194157	1194157	+	A	A	G	Missense_Mutation	SNP	ENST00000621226.2	exon34	c.A14803G	p.T4935A	exonic	ENSG00000215182.8	.	nonsynonymous SNV	ENSG00000215182.8:ENST00000621226.2:exon34:c.A14803G:p.T4935A	11p15.5	C3L-04080	.	.	.	.	.	.	.	.	.	0.5	.	T	.	.	.	.	.	.	.	0.289	.	.	.	.	.	0.370	.	.	T	T	T	.	.	3.208	23.900	0.732	N	.	.	.	.	.	0.000	0.057	0.061	0.045	0.079	0.186	4.830	2.470	0.362	1.307	0.746	0.000	0.998	0.965	.	von_Willebrand_factor,_type_D_domain	.	.	.	MUC5AC	358	0	385	86	0.182590233545648	TRUE	TRUE
ENSG00000254598.3	.	BCM	GRCh38.p13	chr11	11352117	11352117	+	C	C	T	Missense_Mutation	SNP	ENST00000528848.3	exon1	c.G1003A	p.G335S	exonic	ENSG00000254598.3	.	nonsynonymous SNV	ENSG00000254598.3:ENST00000528848.3:exon1:c.G1003A:p.G335S	11p15.4	C3L-04080	.	.	.	.	.	.	.	.	.	0.14	.	T	B	B	.	N	N	T	.	0.140	.	.	T	.	.	0.223	0.130	T	T	T	T	.	T	1.170	13.400	0.828	N	N	.	.	.	.	1.000	0.294	0.333	0.284	0.331	.	1.920	0.907	2.204	0.288	0.445	1.000	0.561	0.832	940	.	.	.	.	CSNK2A3	553	0	644	117	0.153745072273325	NA	TRUE
ENSG00000166012.17	.	BCM	GRCh38.p13	chr11	93738402	93738402	+	G	G	A	Missense_Mutation	SNP	ENST00000448108.7	exon3	c.C166T	p.P56S	exonic	ENSG00000166012.17	.	nonsynonymous SNV	ENSG00000166012.17:ENST00000448108.7:exon3:c.C166T:p.P56S	11q21	C3L-04080	8.253e-06	0	0	0	0	1.502e-05	0	0	rs764603250	1.18	T	T	B	B	N	N	L	.	D	0.157	T	T	T	0.013	0.199	0.168	0.111	T	.	T	T	T	T	0.738	8.798	0.584	N	N	-0.689	0.831	-0.811	0.743	1.000	0.722	0.672	0.699	0.658	.	5.360	-0.761	0.562	0.222	0.618	0.008	0.008	0.166	831	.	.	.	.	TAF1D	124	0	152	23	0.131428571428571	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3L-04080	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	307	0	412	67	0.139874739039666	TRUE	TRUE
ENSG00000178498.16	.	BCM	GRCh38.p13	chr12	57607470	57607470	+	G	G	A	Missense_Mutation	SNP	ENST00000337737.8	exon5	c.G607A	p.G203S	exonic	ENSG00000178498.16	.	nonsynonymous SNV	ENSG00000178498.16:ENST00000337737.8:exon5:c.G607A:p.G203S	12q13.3	C3L-04080	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	D	D	L	T	N	0.363	T	T	T	0.061	0.472	0.524	1.543	T	T	T	T	T	T	2.354	21.900	0.984	N	.	-0.335	1.529	-0.201	1.784	0.997	0.732	0.644	0.744	0.636	.	4.290	3.330	0.693	1.176	0.676	0.238	0.970	0.978	311	.	.	.	.	DTX3	280	0	409	56	0.120430107526882	TRUE	NA
ENSG00000102699.6	.	BCM	GRCh38.p13	chr13	24449752	24449752	+	A	A	C	Missense_Mutation	SNP	ENST00000381989.4	exon25	c.T3080G	p.F1027C	exonic	ENSG00000102699.6	.	nonsynonymous SNV	ENSG00000102699.6:ENST00000381989.4:exon25:c.T3080G:p.F1027C	13q12.12	C3L-04080	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.727	T	T	T	0.406	0.652	0.634	0.654	T	T	D	T	D	T	4.178	28.400	0.994	D	D	0.723	7.455	0.663	7.114	0.972	0.732	0.725	0.744	0.714	.	4.750	4.750	6.135	1.258	0.587	1.000	0.998	0.963	872	von_Willebrand_factor,_type_A	.	.	ID=COSV67960505;OCCURENCE=1(kidney),1(skin)	PARP4	150	0	183	45	0.197368421052632	NA	TRUE
ENSG00000151849.15	.	BCM	GRCh38.p13	chr13	24885315	24885315	+	G	G	T	Missense_Mutation	SNP	ENST00000381884.9	exon13	c.C3438A	p.D1146E	exonic	ENSG00000151849.15	.	nonsynonymous SNV	ENSG00000151849.15:ENST00000381884.9:exon13:c.C3438A:p.D1146E	13q12.12	C3L-04080	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.086	T	T	T	0.019	0.191	0.174	0.112	T	T	T	T	T	T	-0.312	0.295	0.197	N	N	-1.608	0.053	-1.519	0.101	0.832	0.732	0.725	0.744	0.728	.	5.100	-2.030	0.159	-1.329	-1.602	0.813	0.001	0.000	895	.	.	.	.	CENPJ	333	0	483	74	0.132854578096948	TRUE	TRUE
ENSG00000136167.14	.	BCM	GRCh38.p13	chr13	46158909	46158909	+	T	T	C	Missense_Mutation	SNP	ENST00000323076.7	exon3	c.A145G	p.R49G	exonic	ENSG00000136167.14	.	nonsynonymous SNV	ENSG00000136167.14:ENST00000323076.7:exon3:c.A145G:p.R49G	13q14.13	C3L-04080	.	.	.	.	.	.	.	.	.	10.20	D	D	B	B	D	N	L	T	D	0.345	T	T	D	0.289	0.460	0.634	0.465	T	D	T	T	D	D	2.639	22.700	0.990	D	D	-0.233	1.786	-0.194	1.800	1.000	0.672	0.702	0.602	0.530	.	5.760	-0.102	1.486	0.142	0.665	0.783	0.962	0.931	868	EF-hand_domain	.	.	ID=COSV59939986;OCCURENCE=1(large_intestine)	LCP1	297	1	374	75	0.167037861915367	TRUE	TRUE
ENSG00000178115.11	.	BCM	GRCh38.p13	chr15	30557812	30557812	+	C	C	T	Missense_Mutation	SNP	ENST00000562783.1	exon9	c.C653T	p.A218V	exonic	ENSG00000178115.11	.	nonsynonymous SNV	ENSG00000178115.11:ENST00000562783.1:exon9:c.C653T:p.A218V	15q13.2	C3L-04080	.	.	.	.	.	.	.	.	.	1.10	D	T	.	.	.	.	.	T	N	0.068	.	.	T	.	.	0.081	0.480	.	.	T	T	.	T	1.673	16.850	0.996	N	N	.	.	.	.	0.000	0.554	0.588	0.618	0.621	.	0.770	0.770	0.350	-0.150	0.255	0.005	0.002	0.010	976	.	.	.	.	GOLGA8Q	510	0	584	38	0.0610932475884244	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674290	7674299	+	CCTAGGAGAT	CCTAGGAGAT	-	Frame_Shift_Del	DEL	ENST00000269305.8	exon7	c.673delG	p.V225Lfs*22	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon7:c.673delG:p.V225Lfs*22	17p13.1	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	474	0	442	63	0.124752475247525	TRUE	TRUE
ENSG00000154975.14	.	BCM	GRCh38.p13	chr17	52072333	52072333	+	C	C	A	Missense_Mutation	SNP	ENST00000451037.7	exon2	c.G122T	p.G41V	exonic	ENSG00000154975.14	.	nonsynonymous SNV	ENSG00000154975.14:ENST00000451037.7:exon2:c.G122T:p.G41V	17q21.33	C3L-04080	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.915	T	T	D	0.437	.	0.814	1.346	D	T	D	D	D	D	4.770	33	0.998	D	D	0.795	8.684	0.821	10.759	1.000	0.554	0.574	0.618	0.564	.	6.170	6.170	7.158	1.026	0.599	1.000	1.000	0.998	903	Alpha_carbonic_anhydrase_domain	.	.	ID=COSV53360365;OCCURENCE=1(endometrium)	CA10	281	0	333	77	0.18780487804878	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51047216	51047216	+	T	T	C	Missense_Mutation	SNP	ENST00000342988.8	exon2	c.T170C	p.L57S	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon2:c.T170C:p.L57S	18q21.2	C3L-04080	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.989	D	D	D	0.957	0.811	0.983	3.328	D	D	D	D	D	D	4.102	27.800	0.999	D	D	0.978	13.234	0.913	14.306	1.000	0.706	0.725	0.710	0.613	.	5.860	5.860	8.017	1.124	0.665	1.000	1.000	0.991	672	MAD_homology_1,_Dwarfin-type;MAD_homology,_MH1	.	.	ID=COSV61684770;OCCURENCE=2(pancreas)	SMAD4	205	0	208	44	0.174603174603175	TRUE	TRUE
ENSG00000089820.16	.	BCM	GRCh38.p13	chrX	153919238	153919238	+	G	G	A	Missense_Mutation	SNP	ENST00000350060.10	exon6	c.C727T	p.R243C	exonic	ENSG00000089820.16	.	nonsynonymous SNV	ENSG00000089820.16:ENST00000350060.10:exon6:c.C727T:p.R243C	Xq28	C3L-04080	.	.	.	.	.	.	.	.	.	11.19	D	D	D	P	N	D	M	T	D	0.583	T	T	D	0.254	0.716	0.716	1.551	T	D	T	T	D	D	3.210	23.900	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.670	3.760	1.577	1.157	0.654	0.971	0.417	0.624	180	F-BAR_domain	.	.	.	ARHGAP4	230	1	226	76	0.251655629139073	TRUE	TRUE
ENSG00000158008.10	.	BCM	GRCh38.p13	chr1	26023264	26023264	+	G	G	A	Silent	SNP	ENST00000374280.4	exon1	c.G618A	p.P206P	exonic	ENSG00000158008.10	.	synonymous SNV	ENSG00000158008.10:ENST00000374280.4:exon1:c.G618A:p.P206P	1p36.11	C3L-04080	9.742e-06	0	9.211e-05	0	0	0	0	0	rs768099208	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65338459;OCCURENCE=1(large_intestine),1(endometrium)	EXTL1	51	0	85	26	0.234234234234234	TRUE	TRUE
ENSG00000032389.12	.	BCM	GRCh38.p13	chr2	3194076	3194076	+	T	T	C	Silent	SNP	ENST00000382125.8	exon7	c.A744G	p.G248G	exonic	ENSG00000032389.12	.	synonymous SNV	ENSG00000032389.12:ENST00000382125.8:exon7:c.A744G:p.G248G	2p25.3	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EIPR1	324	0	339	81	0.192857142857143	TRUE	TRUE
ENSG00000244607.7	.	BCM	GRCh38.p13	chr3	42752710	42752710	+	G	G	A	Silent	SNP	ENST00000310232.11	exon4	c.C378T	p.A126A	exonic	ENSG00000244607.7;ENSG00000280571.2	.	synonymous SNV	ENSG00000244607.7:ENST00000310232.11:exon4:c.C378T:p.A126A,ENSG00000280571.2:ENST00000648550.1:exon5:c.C447T:p.A149A	3p22.1	C3L-04080	1.649e-05	0	0	0	0	1.5e-05	0	6.06e-05	rs141032680	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC13	134	0	211	39	0.156	TRUE	NA
ENSG00000138778.13	.	BCM	GRCh38.p13	chr4	103158638	103158638	+	A	A	G	Silent	SNP	ENST00000265148.9	exon23	c.T2850C	p.S950S	exonic	ENSG00000138778.13	.	synonymous SNV	ENSG00000138778.13:ENST00000265148.9:exon23:c.T2850C:p.S950S	4q24	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CENPE	98	1	108	6	0.0526315789473684	NA	TRUE
ENSG00000019995.6	.	BCM	GRCh38.p13	chr10	124983682	124983682	+	T	T	A	Silent	SNP	ENST00000359653.4	exon8	c.T1902A	p.A634A	exonic	ENSG00000019995.6	.	synonymous SNV	ENSG00000019995.6:ENST00000359653.4:exon8:c.T1902A:p.A634A	10q26.13	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZRANB1	107	0	165	14	0.0782122905027933	TRUE	TRUE
ENSG00000108001.14	.	BCM	GRCh38.p13	chr10	129840887	129840887	+	C	C	T	Silent	SNP	ENST00000355311.10	exon14	c.G1518A	p.S506S	exonic	ENSG00000108001.14	.	synonymous SNV	ENSG00000108001.14:ENST00000355311.10:exon14:c.G1518A:p.S506S	10q26.3	C3L-04080	0.0002	0	0	0	0.0011	0.0002	0	0.0001	rs372476626	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62473166;OCCURENCE=1(large_intestine),1(stomach),1(endometrium)	EBF3	121	0	151	37	0.196808510638298	TRUE	TRUE
ENSG00000158270.12	.	BCM	GRCh38.p13	chr18	480723	480723	+	G	G	A	Silent	SNP	ENST00000400256.5	exon2	c.C42T	p.F14F	exonic	ENSG00000158270.12	.	synonymous SNV	ENSG00000158270.12:ENST00000400256.5:exon2:c.C42T:p.F14F	18p11.32	C3L-04080	8.237e-06	0	0	0	0	1.498e-05	0	0	rs778096255	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV68375160;OCCURENCE=1(biliary_tract),1(upper_aerodigestive_tract)	COLEC12	383	0	485	62	0.113345521023766	TRUE	TRUE
ENSG00000101052.13	.	BCM	GRCh38.p13	chr20	43603768	43603768	+	C	C	T	Silent	SNP	ENST00000373030.8	exon4	c.C216T	p.I72I	exonic	ENSG00000101052.13	.	synonymous SNV	ENSG00000101052.13:ENST00000373030.8:exon4:c.C216T:p.I72I	20q13.12	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IFT52	160	0	248	33	0.117437722419929	TRUE	TRUE
ENSG00000142961.14	.	BCM	GRCh38.p13	chr1	46613356	46613356	+	C	C	-	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000142961.14	ENST00000371940.1:c.-35delG	.	.	1p33	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MOB3C	87	0	81	23	0.221153846153846	TRUE	TRUE
ENSG00000203761.5	.	BCM	GRCh38.p13	chr1	155747925	155747925	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000203761.5	.	.	.	1q22	C3L-04080	1.786e-05	9.968e-05	0	0	0	1.558e-05	0	0	rs755983569	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MSTO2P	32	0	67	7	0.0945945945945946	TRUE	NA
ENSG00000254106.1	.	BCM	GRCh38.p13	chr5	109884463	109884463	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000254106.1	.	.	.	5q21.3	C3L-04080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC01848	317	0	381	66	0.147651006711409	TRUE	NA
ENSG00000127334.11	.	BCM	GRCh38.p13	chr12	67651533	67651533	+	A	A	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000127334.11	.	.	.	12q15	C3L-04080	.	.	.	.	.	.	.	.	.	1.13	D	.	.	.	.	N	.	T	N	.	T	T	.	0.011	0.261	0.238	.	.	T	T	T	T	T	0.441	5.871	0.359	N	N	-1.189	0.235	-1.413	0.145	1.000	0.455	0.374	0.607	0.550	.	4.170	-6.380	0.155	-0.779	-0.683	0.000	0.000	0.000	569	.	.	.	.	DYRK2	152	0	228	46	0.167883211678832	TRUE	TRUE
ENSG00000142675.18	.	BCM	GRCh38.p13	chr1	26184135	26184149	+	CTCCCAGGTAACAGG	CTCCCAGGTAACAGG	-	Frame_Shift_Del	DEL	ENST00000374253.9	exon10	c.941_947del	p.S314Wfs*49	exonic	ENSG00000142675.18	.	frameshift deletion	ENSG00000142675.18:ENST00000374253.9:exon10:c.941_947del:p.S314Wfs*49	1p36.11	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNKSR1	393	1	423	53	0.111344537815126	TRUE	TRUE
ENSG00000198216.12	.	BCM	GRCh38.p13	chr1	181755330	181755330	+	G	G	A	Missense_Mutation	SNP	ENST00000367573.7	exon28	c.G3922A	p.V1308I	exonic	ENSG00000198216.12	.	nonsynonymous SNV	ENSG00000198216.12:ENST00000367573.7:exon28:c.G3922A:p.V1308I	1q25.3	C3N-03853	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	N	0.625	D	D	D	0.867	0.608	0.935	1.338	T	D	D	D	D	D	3.799	25.800	0.999	D	D	0.933	11.934	0.892	13.416	1.000	0.707	0.725	0.574	0.564	.	5.290	5.290	9.818	1.176	0.674	1.000	0.996	0.989	692	Ion_transport_domain	.	.	.	CACNA1E	220	0	294	49	0.142857142857143	TRUE	TRUE
ENSG00000162687.18	.	BCM	GRCh38.p13	chr1	196331196	196331196	+	A	A	T	Missense_Mutation	SNP	ENST00000294725.13	exon18	c.T2063A	p.L688H	exonic	ENSG00000162687.18	.	nonsynonymous SNV	ENSG00000162687.18:ENST00000294725.13:exon18:c.T2063A:p.L688H	1q31.3	C3N-03853	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.933	D	D	D	0.875	0.575	0.859	1.351	D	T	D	D	D	D	4.070	27.500	0.985	D	D	0.849	9.811	0.800	10.125	1.000	0.615	0.574	0.659	0.621	.	5.260	5.260	9.325	1.312	0.691	1.000	0.998	0.996	528	.	.	.	.	KCNT2	219	0	286	34	0.10625	TRUE	TRUE
ENSG00000135976.20	.	BCM	GRCh38.p13	chr2	97152534	97152534	+	G	G	A	Missense_Mutation	SNP	ENST00000420699.9	exon14	c.G1193A	p.R398K	exonic	ENSG00000135976.20	.	nonsynonymous SNV	ENSG00000135976.20:ENST00000420699.9:exon14:c.G1193A:p.R398K	2q11.2	C3N-03853	.	.	.	.	.	.	.	.	.	2.19	D	T	B	B	.	D	N	T	N	0.201	T	T	T	0.042	0.594	0.040	.	T	T	T	T	T	T	3.310	24.100	0.276	N	N	-1.116	0.293	-1.180	0.300	0.000	0.554	0.588	0.618	0.636	.	1.340	1.340	0.339	0.407	0.563	0.015	0.008	0.010	229	.	.	.	.	ANKRD36	120	0	114	27	0.191489361702128	NA	TRUE
ENSG00000075568.17	.	BCM	GRCh38.p13	chr2	97796361	97796361	+	A	A	-	Frame_Shift_Del	DEL	ENST00000186436.10	exon28	c.3057delT	p.F1019Lfs*3	exonic	ENSG00000075568.17	.	frameshift deletion	ENSG00000075568.17:ENST00000186436.10:exon28:c.3057delT:p.F1019Lfs*3	2q11.2	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM131	111	0	209	32	0.132780082987552	TRUE	TRUE
ENSG00000125618.17	.	BCM	GRCh38.p13	chr2	113241718	113241718	+	C	C	T	Missense_Mutation	SNP	ENST00000429538.8	exon7	c.G610A	p.D204N	exonic	ENSG00000125618.17	.	nonsynonymous SNV	ENSG00000125618.17:ENST00000429538.8:exon7:c.G610A:p.D204N	2q14.1	C3N-03853	.	.	.	.	.	.	.	.	rs868276472	11.20	D	T	P	B	D	D	L	D	N	0.299	D	D	D	0.492	0.260	0.893	0.047	T	T	T	T	D	D	2.427	22.200	0.998	D	D	0.255	3.557	0.344	3.985	1.000	0.515	0.551	0.604	0.635	.	4.690	4.690	6.721	1.026	0.599	1.000	1.000	0.799	623	.	.	.	.	PAX8	718	0	962	63	0.0614634146341463	TRUE	NA
ENSG00000183960.9	.	BCM	GRCh38.p13	chr3	19533635	19533635	+	A	A	G	Missense_Mutation	SNP	ENST00000328405.7	exon16	c.A2860G	p.I954V	exonic	ENSG00000183960.9	.	nonsynonymous SNV	ENSG00000183960.9:ENST00000328405.7:exon16:c.A2860G:p.I954V	3p24.3	C3N-03853	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	N	N	D	N	0.021	D	D	D	0.241	0.304	0.625	0.020	T	T	T	T	T	T	0.074	1.871	0.280	N	N	-0.953	0.457	-0.810	0.744	0.000	0.638	0.588	0.653	0.564	.	5.360	2.000	0.487	0.046	0.756	0.001	0.601	0.905	693	.	.	.	.	KCNH8	404	0	479	82	0.146167557932264	TRUE	TRUE
ENSG00000169379.16	.	BCM	GRCh38.p13	chr3	94043047	94043047	+	C	C	A	Missense_Mutation	SNP	ENST00000394222.8	exon7	c.C831A	p.N277K	exonic	ENSG00000169379.16	.	nonsynonymous SNV	ENSG00000169379.16:ENST00000394222.8:exon7:c.C831A:p.N277K	3q11.2	C3N-03853	0.0014	0.0019	0.0007	0.0021	0.0005	0.0009	0	0.0039	rs139997243	1.20	T	T	B	B	N	D	N	T	N	0.100	T	T	T	0.045	.	0.323	0.084	T	T	T	T	T	T	0.586	7.377	0.532	N	N	-1.158	0.258	-0.929	0.581	0.000	0.615	0.588	0.659	0.655	.	5.200	2.440	0.227	-0.131	-0.107	0.997	0.044	0.169	631	.	.	.	ID=COSV57397738;OCCURENCE=2(oesophagus),3(central_nervous_system),1(pancreas),1(skin),1(prostate),1(endometrium)	ARL13B	141	0	181	31	0.14622641509434	TRUE	TRUE
ENSG00000113389.16	.	BCM	GRCh38.p13	chr5	32712329	32712329	+	G	G	C	Missense_Mutation	SNP	ENST00000265074.13	exon1	c.G553C	p.G185R	exonic	ENSG00000113389.16	.	nonsynonymous SNV	ENSG00000113389.16:ENST00000265074.13:exon1:c.G553C:p.G185R	5p13.3	C3N-03853	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.800	D	D	D	0.844	0.879	0.946	.	T	D	D	D	D	D	4.564	32	0.998	D	D	0.518	5.176	0.462	4.831	1.000	0.549	0.627	0.607	0.527	.	4.890	4.020	7.926	1.172	0.672	1.000	1.000	0.999	844	Receptor,_ligand_binding_region	.	.	.	NPR3	174	0	351	35	0.0906735751295337	TRUE	TRUE
ENSG00000079215.14	.	BCM	GRCh38.p13	chr5	36686069	36686069	+	C	C	T	Missense_Mutation	SNP	ENST00000265113.9	exon10	c.C1429T	p.R477C	exonic	ENSG00000079215.14	.	nonsynonymous SNV	ENSG00000079215.14:ENST00000265113.9:exon10:c.C1429T:p.R477C	5p13.2	C3N-03853	8.246e-06	0	0	0	0	0	0	6.058e-05	rs766340486	19.20	D	D	D	D	D	D	H	T	D	0.845	D	D	D	0.806	0.683	0.894	1.483	D	D	D	D	D	D	4.584	32	0.999	D	D	1.025	14.741	0.951	16.112	1.000	0.707	0.618	0.725	0.542	.	5.620	5.620	7.834	1.026	0.599	1.000	0.998	0.945	697	.	.	.	ID=COSV54314181;OCCURENCE=1(large_intestine),2(NS),2(skin)	SLC1A3	540	1	1003	116	0.103663985701519	TRUE	TRUE
ENSG00000086570.12	.	BCM	GRCh38.p13	chr5	151531799	151531799	+	G	G	A	Missense_Mutation	SNP	ENST00000261800.5	exon13	c.C9599T	p.T3200M	exonic	ENSG00000086570.12	.	nonsynonymous SNV	ENSG00000086570.12:ENST00000261800.5:exon13:c.C9599T:p.T3200M	5q33.1	C3N-03853	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	N	D	M	T	D	0.455	T	T	D	0.357	0.593	0.868	0.549	T	T	T	T	D	D	3.836	26.000	0.998	D	D	0.691	6.998	0.580	5.982	1.000	0.497	0.590	0.547	0.542	.	5.340	5.340	9.810	1.176	0.676	1.000	0.922	0.567	898	Cadherin-like	.	.	ID=COSV55822841;OCCURENCE=1(upper_aerodigestive_tract)	FAT2	614	0	727	163	0.18314606741573	TRUE	TRUE
ENSG00000155511.18	.	BCM	GRCh38.p13	chr5	153811148	153811148	+	G	G	A	Missense_Mutation	SNP	ENST00000285900.10	exon16	c.G2644A	p.D882N	exonic	ENSG00000155511.18	.	nonsynonymous SNV	ENSG00000155511.18:ENST00000285900.10:exon16:c.G2644A:p.D882N	5q33.2	C3N-03853	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	D	D	L	T	N	0.653	T	T	T	0.140	0.171	0.806	1.918	T	T	T	T	D	D	3.651	25.200	0.999	D	D	0.674	6.771	0.691	7.587	1.000	0.554	0.574	0.618	0.564	.	5.030	5.030	9.367	1.174	0.676	1.000	0.993	0.994	792	.	.	.	.	GRIA1	552	0	696	144	0.171428571428571	TRUE	TRUE
ENSG00000184347.15	.	BCM	GRCh38.p13	chr5	168724432	168724432	+	G	G	A	Nonsense_Mutation	SNP	ENST00000519560.6	exon21	c.C2323T	p.R775X	exonic	ENSG00000184347.15	.	stopgain	ENSG00000184347.15:ENST00000519560.6:exon21:c.C2323T:p.R775X	5q34	C3N-03853	8.389e-06	0	8.749e-05	0	0	0	0	0	rs767878241	5.6	.	.	.	.	D	A	.	.	.	0.962	.	.	.	.	.	.	.	.	.	D	D	.	.	8.506	43	0.998	D	N	0.716	7.346	0.543	5.570	0.001	0.615	0.574	0.659	0.621	.	4.870	2.840	3.986	1.166	0.663	1.000	0.992	0.981	920	.	.	.	.	SLIT3	153	0	229	33	0.125954198473282	TRUE	NA
ENSG00000184347.15	.	BCM	GRCh38.p13	chr5	168806453	168806453	+	C	C	T	Missense_Mutation	SNP	ENST00000519560.6	exon9	c.G928A	p.V310I	exonic	ENSG00000184347.15	.	nonsynonymous SNV	ENSG00000184347.15:ENST00000519560.6:exon9:c.G928A:p.V310I	5q34	C3N-03853	4.121e-05	9.612e-05	8.637e-05	0	0	4.499e-05	0	0	rs184054777	2.20	T	D	B	B	N	D	N	T	N	0.049	T	T	T	0.050	.	0.217	0.256	T	T	T	T	T	T	1.156	13.270	0.996	N	N	-0.446	1.285	-0.307	1.550	0.959	0.554	0.563	0.618	0.621	.	5.520	4.650	0.564	0.128	0.599	0.279	0.951	0.956	937	Leucine-rich_repeat_N-terminal_domain	.	.	ID=COSV100270139;OCCURENCE=1(stomach)	SLIT3	110	0	145	51	0.260204081632653	TRUE	NA
ENSG00000197283.17	.	BCM	GRCh38.p13	chr6	33443736	33443736	+	G	G	A	Missense_Mutation	SNP	ENST00000646630.1	exon15	c.G3184A	p.G1062R	exonic	ENSG00000197283.17	.	nonsynonymous SNV	ENSG00000197283.17:ENST00000646630.1:exon15:c.G3184A:p.G1062R	6p21.32	C3N-03853	.	.	.	.	.	.	.	.	.	4.20	T	T	P	B	N	D	L	D	N	0.510	T	T	D	0.403	0.313	0.513	1.827	T	T	T	T	T	T	2.285	21.500	0.960	D	N	-0.130	2.081	-0.007	2.336	1.000	0.672	0.602	0.702	0.528	.	4.090	4.090	1.614	1.171	0.612	0.962	0.998	0.933	490	Domain_of_unknown_function_DUF3498	.	.	.	SYNGAP1	98	0	119	24	0.167832167832168	TRUE	NA
ENSG00000136279.20	.	BCM	GRCh38.p13	chr7	44059554	44059554	+	G	G	C	Missense_Mutation	SNP	ENST00000448521.5	exon11	c.G943C	p.E315Q	exonic	ENSG00000136279.20	.	nonsynonymous SNV	ENSG00000136279.20:ENST00000448521.5:exon11:c.G943C:p.E315Q	7p13	C3N-03853	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.124	T	T	T	0.061	0.222	0.667	0.105	T	T	T	T	T	T	1.218	13.780	0.892	N	N	-0.254	1.730	-0.310	1.544	1.000	0.722	0.699	0.725	0.714	.	5.620	3.680	0.110	1.176	0.676	0.000	0.007	0.162	693	.	.	.	.	DBNL	209	0	290	68	0.189944134078212	TRUE	TRUE
ENSG00000013374.16	.	BCM	GRCh38.p13	chr7	151356192	151356195	+	ATCA	ATCA	-	Frame_Shift_Del	DEL	ENST00000470229.6	exon7	c.663_666del	p.I223Efs*12	exonic	ENSG00000013374.16	.	frameshift deletion	ENSG00000013374.16:ENST00000470229.6:exon7:c.663_666del:p.I223Efs*12	7q36.1	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NUB1	353	0	547	73	0.117741935483871	TRUE	TRUE
ENSG00000147573.17	.	BCM	GRCh38.p13	chr8	66128358	66128358	+	C	C	T	Nonsense_Mutation	SNP	ENST00000315962.9	exon2	c.C223T	p.R75X	exonic	ENSG00000147573.17	.	stopgain	ENSG00000147573.17:ENST00000315962.9:exon2:c.C223T:p.R75X	8q13.1	C3N-03853	8.247e-06	0	0	0	0.0002	0	0	0	rs750201649	5.6	.	.	.	.	D	A	.	.	.	0.526	.	.	.	.	.	.	.	.	.	D	D	.	.	6.974	36	0.998	D	N	0.750	7.883	0.624	6.538	1.000	0.447	0.547	0.573	0.530	.	5.810	4.910	3.292	1.026	0.597	1.000	1.000	0.997	910	Zinc_finger,_RING-type;RING-type_zinc-finger,_LisH_dimerisation_motif	.	.	ID=COSV52545400;OCCURENCE=1(breast)	TRIM55	104	0	139	28	0.167664670658683	TRUE	TRUE
ENSG00000174429.4	.	BCM	GRCh38.p13	chr8	106769954	106769954	+	-	NA	G	Frame_Shift_Ins	NA	ENST00000311955.4	exon1	c.236dupC	p.S81Vfs*20	exonic	ENSG00000174429.4	.	frameshift insertion	ENSG00000174429.4:ENST00000311955.4:exon1:c.236dupC:p.S81Vfs*20	8q23.1	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABRA	NA	NA	NA	NA	NA	NA	NA
ENSG00000153707.17	.	BCM	GRCh38.p13	chr9	8518378	8518378	+	C	C	A	Missense_Mutation	SNP	ENST00000381196.8	exon18	c.G1013T	p.S338I	exonic	ENSG00000153707.17	.	nonsynonymous SNV	ENSG00000153707.17:ENST00000381196.8:exon18:c.G1013T:p.S338I	9p24.1	C3N-03853	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	H	T	D	0.933	D	D	D	0.609	0.618	0.595	.	D	T	D	D	D	.	3.859	26.100	0.997	D	D	0.846	9.747	0.779	9.527	1.000	0.706	0.574	0.710	0.564	.	5.190	5.190	7.905	1.026	0.549	1.000	1.000	0.997	625	Fibronectin_type_III	.	.	.	PTPRD	141	0	127	37	0.225609756097561	TRUE	TRUE
ENSG00000165238.16	.	BCM	GRCh38.p13	chr9	93308378	93308378	+	G	G	A	Missense_Mutation	SNP	ENST00000297954.8	exon28	c.G6421A	p.A2141T	exonic	ENSG00000165238.16	.	nonsynonymous SNV	ENSG00000165238.16:ENST00000297954.8:exon28:c.G6421A:p.A2141T	9q22.31	C3N-03853	0	0	0	0	0	0	0	0	rs537020225	0.20	T	T	P	B	N	N	N	T	N	0.113	T	T	T	0.112	0.082	0.139	0.134	T	T	T	T	T	T	0.239	3.570	0.620	N	N	-1.059	0.345	-1.129	0.347	0.967	0.696	0.590	0.723	0.542	.	4.920	-4.300	0.085	-1.161	-0.794	0.002	0.940	0.952	908	.	.	.	.	WNK2	224	0	221	53	0.193430656934307	TRUE	NA
ENSG00000171501.10	.	BCM	GRCh38.p13	chr9	122553904	122553904	+	C	C	G	Missense_Mutation	SNP	ENST00000373688.3	exon1	c.C693G	p.I231M	exonic	ENSG00000171501.10	.	nonsynonymous SNV	ENSG00000171501.10:ENST00000373688.3:exon1:c.C693G:p.I231M	9q33.2	C3N-03853	.	.	.	.	.	.	.	.	.	2.19	D	.	P	P	N	N	L	T	D	.	T	T	T	0.057	0.425	0.451	0.141	T	T	T	T	T	T	1.044	12.170	0.992	N	N	-0.464	1.249	-0.557	1.111	0.017	0.487	0.574	0.574	0.542	.	4.560	1.480	-2.507	0.907	0.572	0.000	0.017	0.014	905	GPCR,_rhodopsin-like,_7TM	.	.	.	OR1N2	404	1	377	58	0.133333333333333	TRUE	TRUE
ENSG00000203772.7	.	BCM	GRCh38.p13	chr10	133423291	133423291	+	G	G	A	Missense_Mutation	SNP	ENST00000414069.2	exon2	c.C391T	p.R131C	exonic	ENSG00000203772.7	.	nonsynonymous SNV	ENSG00000203772.7:ENST00000414069.2:exon2:c.C391T:p.R131C	10q26.3	C3N-03853	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	.	N	N	T	N	0.105	T	T	D	0.023	0.341	0.030	.	T	T	T	T	T	T	0.695	8.412	0.989	N	N	-1.520	0.075	-1.550	0.090	0.999	0.598	0.551	0.608	0.639	.	3.900	-1.750	-1.121	-0.352	-0.198	0.000	0.000	0.000	.	.	.	.	.	SPRN	237	0	311	53	0.145604395604396	TRUE	NA
ENSG00000070047.13	.	BCM	GRCh38.p13	chr11	597467	597467	+	G	G	A	Missense_Mutation	SNP	ENST00000264555.10	exon8	c.G791A	p.R264Q	exonic	ENSG00000070047.13	.	nonsynonymous SNV	ENSG00000070047.13:ENST00000264555.10:exon8:c.G791A:p.R264Q	11p15.5	C3N-03853	9.167e-06	0	0	0	0	1.633e-05	0	0	rs749964878	9.20	D	T	P	B	N	D	L	D	D	0.278	T	T	D	0.323	0.320	0.215	0.111	T	T	T	T	D	D	2.987	23.400	0.999	D	D	0.047	2.683	0.060	2.577	0.994	0.713	0.702	0.780	0.692	.	4.230	3.320	3.804	1.168	0.667	1.000	0.983	0.837	923	.	.	.	.	PHRF1	452	0	417	86	0.170974155069582	TRUE	NA
ENSG00000073921.18	.	BCM	GRCh38.p13	chr11	86031510	86031510	+	A	A	G	Missense_Mutation	SNP	ENST00000393346.8	exon2	c.T232C	p.S78P	exonic	ENSG00000073921.18	.	nonsynonymous SNV	ENSG00000073921.18:ENST00000393346.8:exon2:c.T232C:p.S78P	11q14.2	C3N-03853	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.866	T	T	D	0.326	0.774	0.730	1.388	D	D	D	D	D	D	3.992	26.900	0.999	D	D	0.571	5.640	0.578	5.954	1.000	0.706	0.725	0.710	0.646	.	5.520	5.520	2.766	1.312	0.756	1.000	1.000	0.998	651	ENTH__domain;AP180_N-terminal_homology_(ANTH)_domain	.	.	.	PICALM	175	0	202	57	0.22007722007722	TRUE	TRUE
ENSG00000047617.15	.	BCM	GRCh38.p13	chr12	5565583	5565583	+	C	C	T	Missense_Mutation	SNP	ENST00000650848.1	exon26	c.G2717A	p.R906H	exonic	ENSG00000047617.15	.	nonsynonymous SNV	ENSG00000047617.15:ENST00000650848.1:exon26:c.G2717A:p.R906H	12p13.31	C3N-03853	5.11e-05	0	0	0	0	9.401e-05	0	0	rs192113570	15.17	D	D	.	.	D	D	.	T	D	0.906	D	D	D	0.727	.	0.664	0.412	T	D	D	D	D	D	4.133	28.000	1.000	D	D	0.924	11.684	0.833	11.174	1.000	0.563	0.590	0.602	0.636	.	4.950	4.950	5.864	1.026	0.599	1.000	0.994	0.852	934	.	.	.	ID=COSV59020943;OCCURENCE=1(liver),1(large_intestine),1(NS),1(haematopoietic_and_lymphoid_tissue),1(endometrium)	ANO2	287	0	477	72	0.131147540983607	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245347	25245347	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G38A	p.G13D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G38A:p.G13D	12p12.1	C3N-03853	.	.	.	.	.	.	.	.	rs112445441	18.20	D	D	P	P	D	D	M	D	D	0.977	D	D	D	0.832	0.722	0.974	2.437	D	D	D	D	D	D	3.167	23.800	0.998	D	D	0.646	6.423	0.688	7.529	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	0.999	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497388;OCCURENCE=1(salivary_gland),20(breast),5(liver),16(peritoneum),9(oesophagus),2(genital_tract),17(cervix),4810(large_intestine),1(central_nervous_system),40(biliary_tract),2(pleura),43(ovary),1(bone),7(NS),85(stomach),256(haematopoietic_and_lymphoid_tissue),5(kidney),35(soft_tissue),12(urinary_tract),71(pancreas),23(gastrointestinal_tract_(site_indeterminate)),12(skin),23(prostate),212(lung),24(thyroid),10(upper_aerodigestive_tract),2(thymus),41(small_intestine),81(endometrium)	KRAS	294	0	407	65	0.13771186440678	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675085	7675085	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G527A	p.C176Y	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G527A:p.C176Y	17p13.1	C3N-03853	.	.	.	.	.	.	.	.	rs786202962	20.20	D	D	D	D	D	D	M	D	D	0.977	D	D	D	0.949	0.961	0.986	2.143	D	D	D	D	D	D	4.061	27.400	0.997	D	D	0.857	10.008	0.769	9.258	1.000	0.722	0.698	0.698	0.735	.	5.590	4.610	7.905	1.026	0.599	1.000	0.999	0.932	434	p53,_DNA-binding_domain	.	.	ID=COSV52660760;OCCURENCE=1(salivary_gland),8(breast),9(liver),16(oesophagus),29(large_intestine),8(central_nervous_system),3(biliary_tract),7(ovary),2(bone),1(NS),19(haematopoietic_and_lymphoid_tissue),5(stomach),1(urinary_tract),3(pancreas),2(skin),15(lung),9(upper_aerodigestive_tract),1(thymus),5(endometrium)	TP53	423	0	378	120	0.240963855421687	TRUE	TRUE
ENSG00000182271.13	.	BCM	GRCh38.p13	chr17	30329277	30329277	+	G	G	A	Missense_Mutation	SNP	ENST00000328886.5	exon3	c.C335T	p.S112F	exonic	ENSG00000182271.13	.	nonsynonymous SNV	ENSG00000182271.13:ENST00000328886.5:exon3:c.C335T:p.S112F	17q11.2	C3N-03853	.	.	.	.	.	.	.	.	.	3.20	T	D	B	B	N	N	L	T	D	0.309	T	T	T	0.098	0.643	0.345	0.056	T	T	T	T	D	T	2.302	21.600	0.946	N	N	-0.370	1.450	-0.331	1.501	0.026	0.447	0.547	0.547	0.530	.	5.480	2.250	2.507	1.166	0.606	0.767	0.550	0.585	546	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	TMIGD1	77	0	99	22	0.181818181818182	TRUE	TRUE
ENSG00000188878.19	.	BCM	GRCh38.p13	chr17	75914878	75914878	+	G	G	A	Missense_Mutation	SNP	ENST00000586717.5	exon24	c.C2641T	p.R881W	exonic	ENSG00000188878.19	.	nonsynonymous SNV	ENSG00000188878.19:ENST00000586717.5:exon24:c.C2641T:p.R881W	17q25.1	C3N-03853	.	.	.	.	.	.	.	.	rs1025965803	10.17	.	D	D	D	.	D	M	T	.	0.648	T	T	D	0.301	0.264	0.509	.	T	T	T	T	D	D	4.268	29.300	0.999	D	D	0.750	7.873	0.715	8.041	1.000	0.646	0.670	0.645	0.568	.	5.340	5.340	3.586	1.176	0.676	1.000	1.000	0.983	828	.	.	.	.	FBF1	255	0	318	47	0.128767123287671	TRUE	NA
ENSG00000141434.12	.	BCM	GRCh38.p13	chr18	32210524	32210524	+	G	G	A	Missense_Mutation	SNP	ENST00000269202.11	exon10	c.G943A	p.D315N	exonic	ENSG00000141434.12	.	nonsynonymous SNV	ENSG00000141434.12:ENST00000269202.11:exon10:c.G943A:p.D315N	18q12.1	C3N-03853	2.517e-05	0	0	0.0004	0	0	0	0	rs757121510	0.20	T	T	B	B	N	N	N	T	N	0.084	T	T	T	0.124	0.673	0.211	0.104	T	T	T	T	T	T	-0.556	0.090	0.657	N	N	-1.675	0.040	-1.672	0.057	0.001	0.487	0.574	0.574	0.564	.	5.570	-6.250	0.185	-1.014	-0.176	0.003	0.000	0.020	824	MAM_domain	.	.	ID=COSV52496715;OCCURENCE=1(skin),2(endometrium)	MEP1B	187	0	230	365	0.613445378151261	TRUE	TRUE
ENSG00000186994.11	.	BCM	GRCh38.p13	chr19	8333122	8333122	+	C	C	A	Nonsense_Mutation	SNP	ENST00000593649.5	exon7	c.G1828T	p.E610X	exonic	ENSG00000186994.11	.	stopgain	ENSG00000186994.11:ENST00000593649.5:exon7:c.G1828T:p.E610X	19p13.2	C3N-03853	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	A	.	.	.	0.195	.	.	.	.	.	.	.	.	.	D	D	.	.	6.956	36	0.997	N	N	0.389	4.275	0.126	2.843	0.776	0.672	0.627	0.641	0.711	.	4.790	2.530	2.044	1.014	0.585	0.560	0.041	0.286	934	Ankyrin_repeat-containing_domain	.	.	.	KANK3	614	0	754	128	0.145124716553288	TRUE	TRUE
ENSG00000197054.12	.	BCM	GRCh38.p13	chr19	11978720	11978720	+	C	C	G	Missense_Mutation	SNP	ENST00000358987.8	exon4	c.C796G	p.H266D	exonic	ENSG00000197054.12;ENSG00000267179.1	.	nonsynonymous SNV	ENSG00000197054.12:ENST00000358987.8:exon4:c.C796G:p.H266D,ENSG00000267179.1:ENST00000590798.1:exon4:c.C856G:p.H286D	19p13.2	C3N-03853	.	.	.	.	.	.	.	.	.	1.18	T	T	P	P	.	N	N	T	D	0.147	T	T	T	0.023	0.293	0.055	0.009	.	T	T	T	T	T	-1.478	0.001	0.764	N	N	-1.099	0.308	-1.274	0.226	0.000	0.554	0.588	0.602	0.621	.	1.400	0.169	-4.274	-3.794	-5.007	0.000	0.000	0.000	934	Zinc_finger_C2H2-type	.	.	.	ZNF763	259	0	346	60	0.147783251231527	TRUE	TRUE
ENSG00000196218.13	.	BCM	GRCh38.p13	chr19	38517565	38517565	+	G	G	A	Missense_Mutation	SNP	ENST00000359596.8	exon66	c.G9892A	p.A3298T	exonic	ENSG00000196218.13	.	nonsynonymous SNV	ENSG00000196218.13:ENST00000359596.8:exon66:c.G9892A:p.A3298T	19q13.2	C3N-03853	0.0001	0	0	0	0	1.527e-05	0	0.0007	rs544339193	5.19	T	.	B	B	U	N	N	D	N	0.331	D	D	D	0.271	.	0.928	0.310	T	T	T	T	T	T	1.123	12.990	0.770	D	N	-0.404	1.374	-0.397	1.378	0.002	0.646	0.547	0.645	0.563	.	3.600	2.390	2.957	0.211	0.595	0.558	0.026	0.029	725	.	.	.	ID=COSV62092810;OCCURENCE=1(large_intestine),2(NS)	RYR1	426	0	544	110	0.168195718654434	TRUE	TRUE
ENSG00000186026.7	.	BCM	GRCh38.p13	chr19	44086022	44086022	+	A	A	T	Nonsense_Mutation	SNP	ENST00000421176.4	exon5	c.A544T	p.K182X	exonic	ENSG00000186026.7	.	stopgain	ENSG00000186026.7:ENST00000421176.4:exon5:c.A544T:p.K182X	19q13.31	C3N-03853	.	.	.	.	.	.	.	.	rs868833403	4.5	.	.	.	.	.	D	.	.	.	0.043	.	.	.	.	.	.	.	.	.	D	D	.	.	4.191	28.600	0.991	D	N	-0.094	2.193	-0.481	1.233	0.002	0.372	0.546	0.464	0.492	.	2.590	1.480	-0.077	1.228	0.658	0.000	0.004	0.009	661	Zinc_finger_C2H2-type	.	.	.	ZNF284	170	0	254	44	0.147651006711409	TRUE	NA
ENSG00000089199.10	.	BCM	GRCh38.p13	chr20	5922838	5922838	+	C	C	T	Nonsense_Mutation	SNP	ENST00000378961.9	exon4	c.C694T	p.R232X	exonic	ENSG00000089199.10	.	stopgain	ENSG00000089199.10:ENST00000378961.9:exon4:c.C694T:p.R232X	20p12.3	C3N-03853	2.498e-05	0	0	0	0	0	0	0.0002	rs760333741	3.6	.	.	.	.	N	A	.	.	.	0.516	.	.	.	.	.	.	.	.	.	D	D	.	.	5.181	33	0.997	N	N	0.061	2.736	-0.234	1.706	0.001	0.706	0.590	0.710	0.530	.	5.450	2.260	-0.320	-0.144	0.599	0.004	0.202	0.311	614	.	.	.	.	CHGB	205	0	307	58	0.158904109589041	TRUE	NA
ENSG00000177398.18	.	BCM	GRCh38.p13	chr21	42111704	42111704	+	G	G	A	Missense_Mutation	SNP	ENST00000408910.6	exon12	c.G2098A	p.A700T	exonic	ENSG00000177398.18	.	nonsynonymous SNV	ENSG00000177398.18:ENST00000408910.6:exon12:c.G2098A:p.A700T	21q22.3	C3N-03853	8.691e-06	0	0	0	0	0	0	7.002e-05	rs768607330	2.20	T	D	P	B	N	N	M	T	N	0.057	T	T	T	0.008	0.455	0.245	0.099	T	T	T	T	T	T	0.033	1.555	0.906	N	N	-1.079	0.325	-1.138	0.338	1.000	0.497	0.590	0.578	0.542	.	4.410	0.265	-0.139	-0.849	-0.883	0.000	0.053	0.015	981	.	.	.	ID=COSV61161227;OCCURENCE=1(large_intestine)	UMODL1	51	0	102	21	0.170731707317073	TRUE	TRUE
ENSG00000188937.5	.	BCM	GRCh38.p13	chrX	41473836	41473836	+	C	C	T	Missense_Mutation	SNP	ENST00000342595.2	exon2	c.C383T	p.A128V	exonic	ENSG00000188937.5	.	nonsynonymous SNV	ENSG00000188937.5:ENST00000342595.2:exon2:c.C383T:p.A128V	Xp11.4	C3N-03853	0.0002	0	0	0	0	0	0	0.0013	rs778437203	3.19	T	T	B	B	N	N	N	T	N	0.017	T	T	D	0.211	0.418	0.997	0.797	D	T	T	T	T	T	2.453	22.300	0.917	D	.	.	.	.	.	0.995	.	.	.	.	.	4.640	3.760	3.716	0.086	0.518	0.998	0.995	0.974	69	.	.	.	ID=COSV61180564;OCCURENCE=1(oesophagus)	NYX	129	0	175	47	0.211711711711712	TRUE	TRUE
ENSG00000165288.11	.	BCM	GRCh38.p13	chrX	80707433	80707433	+	G	G	C	Missense_Mutation	SNP	ENST00000373275.5	exon22	c.C2546G	p.S849C	exonic	ENSG00000165288.11	.	nonsynonymous SNV	ENSG00000165288.11:ENST00000373275.5:exon22:c.C2546G:p.S849C	Xq21.1	C3N-03853	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	M	T	D	0.564	T	T	D	0.188	0.227	0.756	1.987	T	D	T	T	D	D	3.835	26.000	0.994	D	.	.	.	.	.	0.355	.	.	.	.	.	4.570	4.570	3.277	1.155	0.613	1.000	1.000	0.996	681	.	.	.	.	BRWD3	209	0	261	43	0.141447368421053	TRUE	TRUE
ENSG00000101972.19	.	BCM	GRCh38.p13	chrX	124037563	124037563	+	G	G	T	Missense_Mutation	SNP	ENST00000371160.5	exon6	c.G325T	p.D109Y	exonic	ENSG00000101972.19	.	nonsynonymous SNV	ENSG00000101972.19:ENST00000371160.5:exon6:c.G325T:p.D109Y	Xq25	C3N-03853	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	M	T	D	0.814	T	T	D	0.479	0.482	0.718	2.504	T	T	D	D	D	D	4.120	27.900	0.995	D	.	.	.	.	.	1.000	.	.	.	.	.	4.940	4.940	8.129	1.161	0.618	1.000	1.000	1.000	866	.	.	.	.	STAG2	141	0	206	18	0.0803571428571429	TRUE	TRUE
ENSG00000183434.10	.	BCM	GRCh38.p13	chrX	133217898	133217898	+	G	G	A	Missense_Mutation	SNP	ENST00000310125.5	exon1	c.C362T	p.T121M	exonic	ENSG00000183434.10	.	nonsynonymous SNV	ENSG00000183434.10:ENST00000310125.5:exon1:c.C362T:p.T121M	Xq26.2	C3N-03853	.	.	.	.	.	.	.	.	.	4.18	D	D	B	B	.	D	N	T	N	0.158	T	T	T	0.062	0.655	0.128	0.207	T	T	T	T	T	D	0.397	5.392	0.708	N	.	.	.	.	.	0.028	.	.	.	.	.	0.226	-0.452	2.411	-1.225	-1.531	1.000	0.433	0.100	434	E2F/DP_family,_winged-helix_DNA-binding_domain	.	.	ID=COSV59536633;OCCURENCE=1(central_nervous_system),1(kidney)	TFDP3	290	0	346	90	0.206422018348624	TRUE	TRUE
ENSG00000144481.17	.	BCM	GRCh38.p13	chr2	233945975	233945975	+	C	C	T	Silent	SNP	ENST00000324695.9	exon7	c.C819T	p.V273V	exonic	ENSG00000144481.17	.	synonymous SNV	ENSG00000144481.17:ENST00000324695.9:exon7:c.C819T:p.V273V	2q37.1	C3N-03853	3.296e-05	0	0	0	0	5.996e-05	0	0	rs200501002	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61222482;OCCURENCE=1(stomach),1(endometrium)	TRPM8	189	0	204	44	0.17741935483871	TRUE	TRUE
ENSG00000090402.8	.	BCM	GRCh38.p13	chr3	165016012	165016012	+	C	C	T	Silent	SNP	ENST00000264382.8	exon32	c.G3828A	p.Q1276Q	exonic	ENSG00000090402.8	.	synonymous SNV	ENSG00000090402.8:ENST00000264382.8:exon32:c.G3828A:p.Q1276Q	3q26.1	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SI	254	0	343	61	0.150990099009901	TRUE	TRUE
ENSG00000112320.12	.	BCM	GRCh38.p13	chr6	107634893	107634893	+	C	C	T	Silent	SNP	ENST00000317357.10	exon6	c.C2049T	p.S683S	exonic	ENSG00000112320.12	.	synonymous SNV	ENSG00000112320.12:ENST00000317357.10:exon6:c.C2049T:p.S683S	6q21	C3N-03853	.	.	.	.	.	.	.	.	rs945395751	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SOBP	118	0	158	37	0.18974358974359	TRUE	NA
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152442186	152442186	+	C	C	T	Silent	SNP	ENST00000367255.10	exon31	c.G3897A	p.A1299A	exonic	ENSG00000131018.24	.	synonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon31:c.G3897A:p.A1299A	6q25.2	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55034127;OCCURENCE=1(cervix),1(pancreas),1(lung)	SYNE1	631	0	710	136	0.160756501182033	TRUE	TRUE
ENSG00000139044.12	.	BCM	GRCh38.p13	chr12	460412	460412	+	C	C	T	Silent	SNP	ENST00000266383.10	exon1	c.C36T	p.L12L	exonic	ENSG00000139044.12	.	synonymous SNV	ENSG00000139044.12:ENST00000266383.10:exon1:c.C36T:p.L12L	12p13.33	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	B4GALNT3	216	0	261	68	0.206686930091185	TRUE	NA
ENSG00000133687.16	.	BCM	GRCh38.p13	chr12	29758754	29758754	+	C	C	T	Silent	SNP	ENST00000539277.6	exon3	c.G504A	p.A168A	exonic	ENSG00000133687.16	.	synonymous SNV	ENSG00000133687.16:ENST00000539277.6:exon3:c.G504A:p.A168A	12p11.22	C3N-03853	0.0001	0	0.0004	0	0	0.0001	0	6.402e-05	rs769031907	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55481117;OCCURENCE=1(pancreas)	TMTC1	267	0	272	55	0.168195718654434	TRUE	TRUE
ENSG00000182870.13	.	BCM	GRCh38.p13	chr12	132247988	132247988	+	G	G	A	Silent	SNP	ENST00000328957.13	exon6	c.C999T	p.R333R	exonic	ENSG00000182870.13	.	synonymous SNV	ENSG00000182870.13:ENST00000328957.13:exon6:c.C999T:p.R333R	12q24.33	C3N-03853	4.709e-05	0	0	0	0	0	0	0.0001	rs554309534	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GALNT9	187	0	184	51	0.217021276595745	TRUE	NA
ENSG00000130477.15	.	BCM	GRCh38.p13	chr19	17641467	17641467	+	G	G	A	Silent	SNP	ENST00000519716.6	exon21	c.C2562T	p.Y854Y	exonic	ENSG00000130477.15	.	synonymous SNV	ENSG00000130477.15:ENST00000519716.6:exon21:c.C2562T:p.Y854Y	19p13.11	C3N-03853	3.312e-05	0	0	0	0	4.495e-05	0	6.056e-05	rs374674567	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UNC13A	316	0	481	74	0.133333333333333	TRUE	NA
ENSG00000188559.15	.	BCM	GRCh38.p13	chr20	20572956	20572956	+	T	T	C	Silent	SNP	ENST00000202677.12	exon21	c.A2820G	p.G940G	exonic	ENSG00000188559.15	.	synonymous SNV	ENSG00000188559.15:ENST00000202677.12:exon21:c.A2820G:p.G940G	20p11.23	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RALGAPA2	275	2	328	36	0.0989010989010989	TRUE	TRUE
ENSG00000146950.13	.	BCM	GRCh38.p13	chrX	9895993	9895993	+	G	G	A	Silent	SNP	ENST00000380913.8	exon4	c.G2085A	p.T695T	exonic	ENSG00000146950.13	.	synonymous SNV	ENSG00000146950.13:ENST00000380913.8:exon4:c.G2085A:p.T695T	Xp22.2	C3N-03853	2.167e-05	0.0002	0	0	0	0	0	0	rs760036869	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66608779;OCCURENCE=1(large_intestine)	SHROOM2	240	1	341	62	0.153846153846154	TRUE	TRUE
ENSG00000180815.14	.	BCM	GRCh38.p13	chrX	19413402	19413402	+	G	G	T	Silent	SNP	ENST00000338883.8	exon11	c.C1653A	p.A551A	exonic	ENSG00000180815.14	.	synonymous SNV	ENSG00000180815.14:ENST00000338883.8:exon11:c.C1653A:p.A551A	Xp22.12	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP3K15	118	1	145	16	0.0993788819875776	TRUE	NA
ENSG00000129680.16	.	BCM	GRCh38.p13	chrX	136231553	136231553	+	G	G	A	Silent	SNP	ENST00000316077.14	exon8	c.C1404T	p.D468D	exonic	ENSG00000129680.16	.	synonymous SNV	ENSG00000129680.16:ENST00000316077.14:exon8:c.C1404T:p.D468D	Xq26.3	C3N-03853	1.219e-05	0	0	0	0	2.146e-05	0	0	rs780117758	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60170289;OCCURENCE=1(stomach)	MAP7D3	121	0	164	30	0.154639175257732	TRUE	TRUE
ENSG00000115806.13	.	BCM	GRCh38.p13	chr2	170929827	170929827	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000115806.13	.	.	.	2q31.1	C3N-03853	7.196e-05	0	0	0	0	0	0	0.0001	rs770400543	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GORASP2	160	0	214	34	0.137096774193548	TRUE	NA
ENSG00000047365.12	.	BCM	GRCh38.p13	chr4	36259845	36259845	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000047365.12;ENSG00000247193.3	dist=15331;dist=11725	.	.	4p14	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARAP2	334	2	446	85	0.160075329566855	TRUE	NA
ENSG00000249740.3	.	BCM	GRCh38.p13	chr5	38823189	38823189	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000249740.3	.	.	.	5p13.1	C3N-03853	.	.	.	.	.	.	.	.	rs984099683	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OSMR-AS1	14	0	12	4	0.25	TRUE	NA
ENSG00000181355.21	.	BCM	GRCh38.p13	chr6	9809630	9809630	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000181355.21	.	.	.	6p24.3	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OFCC1	248	0	300	66	0.180327868852459	TRUE	NA
ENSG00000253763.1	.	BCM	GRCh38.p13	chr14	106056128	106056128	+	G	G	A	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000253763.1	dist=130	.	.	14q32.33	C3N-03853	.	.	.	.	.	.	.	.	rs782376168	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHV3-6	8	0	15	8	0.347826086956522	TRUE	NA
ENSG00000284675.1	.	BCM	GRCh38.p13	chr16	73127389	73127389	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000284675.1	.	.	.	16q22.3	C3N-03853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC116667.2	170	0	228	62	0.213793103448276	TRUE	NA
ENSG00000118473.22	.	BCM	GRCh38.p13	chr1	66682333	66682333	+	G	G	A	Missense_Mutation	SNP	ENST00000371037.9	exon15	c.G1279A	p.G427R	exonic	ENSG00000118473.22	.	nonsynonymous SNV	ENSG00000118473.22:ENST00000371037.9:exon15:c.G1279A:p.G427R	1p31.3	C3N-04283	1.679e-05	0.0001	0	0.0001	0	0	0	0	rs375315309	11.20	D	T	D	D	N	D	M	T	N	0.767	T	T	D	0.239	.	0.110	0.614	D	T	T	T	D	D	4.181	28.500	0.999	D	D	0.572	5.645	0.612	6.371	1.000	0.487	0.547	0.574	0.714	.	5.490	5.490	6.945	1.176	0.676	1.000	1.000	0.996	866	.	.	.	ID=COSV104378051;OCCURENCE=1(small_intestine)	SGIP1	110	0	207	23	0.1	TRUE	NA
ENSG00000184005.11	.	BCM	GRCh38.p13	chr1	76412270	76412270	+	G	G	A	Missense_Mutation	SNP	ENST00000328299.4	exon3	c.G476A	p.R159H	exonic	ENSG00000184005.11	.	nonsynonymous SNV	ENSG00000184005.11:ENST00000328299.4:exon3:c.G476A:p.R159H	1p31.1	C3N-04283	1.65e-05	0	0	0	0	2.999e-05	0	0	rs373383533	12.20	D	T	D	D	D	D	L	T	D	0.815	T	T	T	0.425	.	0.389	0.436	T	T	D	D	D	D	3.758	25.600	0.998	D	D	0.922	11.636	0.939	15.547	1.000	0.693	0.574	0.659	0.564	.	6.170	6.170	9.568	1.176	0.676	1.000	1.000	0.993	658	.	.	.	ID=COSV60323951;OCCURENCE=1(cervix),2(large_intestine),1(central_nervous_system),1(stomach)	ST6GALNAC3	315	0	429	44	0.0930232558139535	TRUE	TRUE
ENSG00000115970.18	.	BCM	GRCh38.p13	chr2	43398002	43398002	+	C	C	T	Missense_Mutation	SNP	ENST00000405006.8	exon29	c.G4196A	p.R1399Q	exonic	ENSG00000115970.18	.	nonsynonymous SNV	ENSG00000115970.18:ENST00000405006.8:exon29:c.G4196A:p.R1399Q	2p21	C3N-04283	1.656e-05	0	0	0	0	2.998e-05	0	0	rs370092582	7.20	T	T	D	P	D	D	M	T	N	0.368	T	T	T	0.069	.	0.156	.	T	T	T	T	D	D	3.357	24.300	1.000	D	N	0.114	2.943	0.190	3.134	1.000	0.706	0.634	0.710	0.613	.	5.170	4.290	4.510	1.026	0.599	1.000	1.000	0.999	927	.	.	.	.	THADA	136	1	277	24	0.079734219269103	TRUE	NA
ENSG00000115085.13	.	BCM	GRCh38.p13	chr2	97735449	97735449	+	G	G	A	Missense_Mutation	SNP	ENST00000264972.9	exon10	c.G1282A	p.G428S	exonic	ENSG00000115085.13	.	nonsynonymous SNV	ENSG00000115085.13:ENST00000264972.9:exon10:c.G1282A:p.G428S	2q11.2	C3N-04283	3.357e-05	0	0	0	0	6.106e-05	0	0	rs149448335	1.20	T	T	B	B	N	N	L	D	N	0.194	T	T	T	0.173	.	0.644	0.709	T	T	T	T	T	T	1.205	13.670	0.731	N	N	-0.786	0.675	-0.673	0.938	0.998	0.554	0.588	0.578	0.605	.	5.370	4.470	0.726	1.120	0.665	0.022	0.117	0.012	456	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	ZAP70	101	0	195	30	0.133333333333333	TRUE	NA
ENSG00000127418.15	.	BCM	GRCh38.p13	chr4	1012561	1012561	+	C	C	G	Missense_Mutation	SNP	ENST00000510644.6	exon2	c.C76G	p.R26G	exonic	ENSG00000127418.15	.	nonsynonymous SNV	ENSG00000127418.15:ENST00000510644.6:exon2:c.C76G:p.R26G	4p16.3	C3N-04283	0.0002	0	0	0	0	0.0005	0	0	rs768315040	6.20	D	D	B	B	U	D	L	T	D	0.288	T	T	D	0.144	.	0.752	0.182	D	T	T	T	T	T	2.488	22.400	0.984	N	N	-0.296	1.623	-0.265	1.638	1.000	0.652	0.552	0.641	0.373	.	2.360	1.470	0.187	0.851	0.495	0.360	0.963	0.943	867	.	.	.	.	FGFRL1	119	0	251	35	0.122377622377622	TRUE	NA
ENSG00000163625.15	.	BCM	GRCh38.p13	chr4	84772873	84772873	+	A	A	G	Missense_Mutation	SNP	ENST00000295888.8	exon30	c.T4811C	p.V1604A	exonic	ENSG00000163625.15	.	nonsynonymous SNV	ENSG00000163625.15:ENST00000295888.8:exon30:c.T4811C:p.V1604A	4q21.23	C3N-04283	.	.	.	.	.	.	.	.	.	11.20	D	D	P	B	D	D	L	T	N	0.836	T	T	T	0.392	0.401	0.298	0.514	D	T	D	D	D	D	3.338	24.200	0.998	D	D	0.399	4.336	0.496	5.125	1.000	0.732	0.574	0.602	0.728	.	5.420	5.420	9.086	1.312	0.756	1.000	1.000	0.999	899	.	.	.	ID=COSV55703811;OCCURENCE=1(large_intestine)	WDFY3	168	0	177	37	0.172897196261682	TRUE	TRUE
ENSG00000050730.16	.	BCM	GRCh38.p13	chr4	121141890	121141890	+	C	C	T	Missense_Mutation	SNP	ENST00000057513.8	exon9	c.G811A	p.G271S	exonic	ENSG00000050730.16	.	nonsynonymous SNV	ENSG00000050730.16:ENST00000057513.8:exon9:c.G811A:p.G271S	4q27	C3N-04283	1.676e-05	0	0	0.0001	0	0	0	6.535e-05	rs746466806	1.20	T	T	P	B	N	N	L	T	D	0.261	T	T	T	0.032	0.456	0.353	0.235	T	T	T	T	T	T	0.649	7.980	0.836	N	N	-0.869	0.560	-0.964	0.535	1.000	0.554	0.588	0.574	0.613	.	4.770	0.700	0.418	-0.237	-0.171	0.001	0.001	0.088	824	.	.	.	ID=COSV50246134;OCCURENCE=1(large_intestine)	TNIP3	73	0	111	8	0.0672268907563025	TRUE	TRUE
ENSG00000112137.17	.	BCM	GRCh38.p13	chr6	13228045	13228045	+	G	G	A	Missense_Mutation	SNP	ENST00000332995.11	exon9	c.G1216A	p.D406N	exonic	ENSG00000112137.17	.	nonsynonymous SNV	ENSG00000112137.17:ENST00000332995.11:exon9:c.G1216A:p.D406N	6p24.1	C3N-04283	1.702e-05	0	0	0.0001	0	0	0	6.132e-05	rs562927111	6.19	T	T	D	P	D	D	L	T	N	0.503	T	T	D	0.212	0.084	0.636	.	T	T	T	T	T	.	3.193	23.800	0.992	D	D	0.455	4.705	0.551	5.659	1.000	0.615	0.588	0.659	0.655	.	5.760	5.760	9.107	1.176	0.676	1.000	0.721	0.836	890	.	.	.	.	PHACTR1	134	0	206	31	0.130801687763713	TRUE	NA
ENSG00000157212.19	.	BCM	GRCh38.p13	chr7	154975833	154975833	+	T	T	C	Missense_Mutation	SNP	ENST00000404141.6	exon6	c.A937G	p.M313V	exonic	ENSG00000157212.19	.	nonsynonymous SNV	ENSG00000157212.19:ENST00000404141.6:exon6:c.A937G:p.M313V	7q36.2	C3N-04283	.	.	.	.	.	.	.	.	.	1.20	D	T	P	B	N	N	N	T	N	0.164	T	T	T	0.023	0.276	0.189	0.157	T	T	T	T	T	T	0.695	8.408	0.871	N	N	-0.906	0.513	-0.984	0.509	0.828	0.707	0.725	0.725	0.636	.	5.040	-2.260	0.321	1.138	0.609	0.098	0.965	0.981	988	.	.	.	.	PAXIP1	271	1	595	58	0.0888208269525268	TRUE	TRUE
ENSG00000148408.13	.	BCM	GRCh38.p13	chr9	138023675	138023675	+	C	C	T	Missense_Mutation	SNP	ENST00000371372.6	exon19	c.C2932T	p.R978W	exonic	ENSG00000148408.13	.	nonsynonymous SNV	ENSG00000148408.13:ENST00000371372.6:exon19:c.C2932T:p.R978W	9q34.3	C3N-04283	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	M	D	D	0.399	D	D	D	0.526	0.359	0.870	1.688	D	D	D	D	D	D	3.348	24.300	0.999	D	N	0.160	3.133	0.015	2.411	0.992	0.598	0.590	0.607	0.639	.	4.040	0.294	0.431	-0.043	0.520	0.813	0.352	0.915	982	.	.	.	.	CACNA1B	304	0	536	147	0.215226939970717	TRUE	TRUE
ENSG00000095713.14	.	BCM	GRCh38.p13	chr10	97896939	97896939	+	C	C	T	Missense_Mutation	SNP	ENST00000370597.8	exon9	c.G1186A	p.D396N	exonic	ENSG00000095713.14	.	nonsynonymous SNV	ENSG00000095713.14:ENST00000370597.8:exon9:c.G1186A:p.D396N	10q24.2	C3N-04283	0	0	0	0	0	0	0	0	rs750669625	11.20	T	D	D	P	D	D	M	T	D	0.607	T	T	D	0.213	.	0.494	0.379	T	T	T	T	D	D	3.084	23.600	0.996	D	D	0.303	3.792	0.206	3.215	1.000	0.497	0.590	0.547	0.613	.	5.170	5.170	7.094	1.026	0.599	1.000	0.022	0.007	248	.	.	.	.	CRTAC1	107	0	146	25	0.146198830409357	TRUE	NA
ENSG00000162298.18	.	BCM	GRCh38.p13	chr11	65131368	65131368	+	T	T	C	Missense_Mutation	SNP	ENST00000377190.7	exon8	c.A664G	p.I222V	exonic	ENSG00000162298.18	.	nonsynonymous SNV	ENSG00000162298.18:ENST00000377190.7:exon8:c.A664G:p.I222V	11q13.1	C3N-04283	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	N	T	N	0.273	T	T	T	0.060	0.378	0.329	1.007	T	T	T	T	T	T	2.543	22.500	0.994	D	D	-0.213	1.841	-0.041	2.224	1.000	0.707	0.672	0.725	0.711	.	4.490	4.490	3.859	1.138	0.665	1.000	1.000	0.990	420	.	.	.	.	SYVN1	184	0	304	30	0.0898203592814371	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-04283	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	251	0	307	52	0.144846796657382	TRUE	TRUE
ENSG00000089250.19	.	BCM	GRCh38.p13	chr12	117272420	117272420	+	C	C	T	Missense_Mutation	SNP	ENST00000317775.11	exon10	c.G1804A	p.D602N	exonic	ENSG00000089250.19	.	nonsynonymous SNV	ENSG00000089250.19:ENST00000317775.11:exon10:c.G1804A:p.D602N	12q24.22	C3N-04283	.	.	.	.	.	.	.	.	.	9.20	T	T	D	P	D	D	N	T	D	0.699	T	T	D	0.212	0.702	0.753	2.233	T	T	T	T	D	D	3.148	23.700	0.999	D	D	0.333	3.954	0.430	4.580	1.000	0.638	0.590	0.653	0.564	.	4.700	4.700	6.172	1.026	0.599	1.000	0.980	0.997	893	Nitric_oxide_synthase,_N-terminal	.	.	.	NOS1	506	1	764	101	0.116763005780347	TRUE	TRUE
ENSG00000183463.6	.	BCM	GRCh38.p13	chr13	27978327	27978327	+	G	G	A	Missense_Mutation	SNP	ENST00000332715.6	exon2	c.C301T	p.R101W	exonic	ENSG00000183463.6	.	nonsynonymous SNV	ENSG00000183463.6:ENST00000332715.6:exon2:c.C301T:p.R101W	13q12.2	C3N-04283	.	.	.	.	.	.	.	.	.	5.20	T	T	D	D	N	N	M	T	N	0.403	T	T	D	0.149	0.593	0.293	0.894	D	T	T	T	T	T	2.143	20.400	0.997	N	N	-0.214	1.838	-0.463	1.264	0.830	0.598	0.590	0.378	0.639	.	4.510	1.140	-0.089	-0.867	-0.197	0.002	0.000	0.003	904	2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline_decarboxylase,_type_1;Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline_decarboxylase	.	.	.	URAD	137	0	284	39	0.120743034055728	TRUE	NA
ENSG00000133958.13	.	BCM	GRCh38.p13	chr14	93540782	93540782	+	A	A	T	Missense_Mutation	SNP	ENST00000393151.6	exon13	c.A1475T	p.D492V	exonic	ENSG00000133958.13	.	nonsynonymous SNV	ENSG00000133958.13:ENST00000393151.6:exon13:c.A1475T:p.D492V	14q32.12	C3N-04283	.	.	.	.	.	.	.	.	.	11.19	T	D	D	D	D	D	N	T	N	0.900	T	T	D	0.442	0.330	0.068	2.535	T	T	D	D	D	.	3.549	24.900	0.992	D	D	0.627	6.212	0.647	6.861	1.000	0.554	0.574	0.602	0.613	.	5.610	5.610	9.067	1.312	0.756	1.000	0.917	0.903	851	.	.	.	.	UNC79	300	1	498	62	0.110714285714286	TRUE	TRUE
ENSG00000237289.10	.	BCM	GRCh38.p13	chr15	43596451	43596451	+	G	G	T	Missense_Mutation	SNP	ENST00000441322.6	exon6	c.G796T	p.D266Y	exonic	ENSG00000237289.10	.	nonsynonymous SNV	ENSG00000237289.10:ENST00000441322.6:exon6:c.G796T:p.D266Y	15q15.3	C3N-04283	.	.	.	.	.	.	.	.	.	13.15	D	D	.	.	D	D	.	T	D	0.980	D	T	D	0.674	0.927	0.851	2.171	D	.	D	D	D	.	4.162	28.300	0.995	D	D	1.061	15.963	0.919	14.589	1.000	0.707	0.574	0.725	0.530	.	4.490	4.490	9.992	1.166	0.608	1.000	1.000	0.983	11	.	.	.	.	CKMT1B	118	0	210	24	0.102564102564103	NA	TRUE
ENSG00000173546.7	.	BCM	GRCh38.p13	chr15	75685440	75685440	+	G	G	C	Missense_Mutation	SNP	ENST00000308508.5	exon4	c.C4051G	p.L1351V	exonic	ENSG00000173546.7	.	nonsynonymous SNV	ENSG00000173546.7:ENST00000308508.5:exon4:c.C4051G:p.L1351V	15q24.2	C3N-04283	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	N	D	L	T	N	0.290	T	T	T	0.116	0.490	0.192	0.342	T	T	T	T	T	T	1.224	13.820	0.700	D	N	-0.192	1.900	-0.080	2.105	1.000	0.653	0.616	0.597	0.639	.	4.760	4.760	0.748	1.057	0.567	0.964	0.755	0.010	162	.	.	.	.	CSPG4	318	0	473	65	0.120817843866171	TRUE	TRUE
ENSG00000168140.5	.	BCM	GRCh38.p13	chr16	4382405	4382405	+	A	A	G	Missense_Mutation	SNP	ENST00000304735.4	exon2	c.A1528G	p.T510A	exonic	ENSG00000168140.5	.	nonsynonymous SNV	ENSG00000168140.5:ENST00000304735.4:exon2:c.A1528G:p.T510A	16p13.3	C3N-04283	.	.	.	.	.	.	.	.	.	5.19	T	T	D	B	N	D	L	D	N	0.232	T	T	D	0.235	0.319	0.755	0.187	T	T	T	T	T	.	1.994	19.210	0.940	D	N	0.161	3.133	0.244	3.404	1.000	0.718	0.551	0.571	0.563	.	5.390	5.390	1.648	1.294	0.729	0.054	0.831	0.810	572	Fibronectin_type_III	.	.	ID=COSV52033235;OCCURENCE=1(urinary_tract)	VASN	300	0	505	61	0.107773851590106	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673787	7673787	+	G	G	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.C833A	p.P278H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.C833A:p.P278H	17p13.1	C3N-04283	.	.	.	.	.	.	.	.	rs876659802	19.20	D	D	D	D	D	D	M	D	D	0.939	D	D	D	0.950	0.953	0.981	0.412	T	D	D	D	D	D	4.340	29.900	0.997	D	D	0.858	10.017	0.768	9.244	1.000	0.722	0.702	0.725	0.735	.	5.130	4.160	10.003	1.172	0.672	1.000	0.996	1.000	432	p53,_DNA-binding_domain	.	.	ID=COSV52665769;OCCURENCE=1(breast),2(oesophagus),1(adrenal_gland),3(large_intestine),3(central_nervous_system),1(ovary),2(haematopoietic_and_lymphoid_tissue),2(soft_tissue),2(pancreas),1(prostate),5(lung),1(upper_aerodigestive_tract)	TP53	657	0	978	141	0.126005361930295	TRUE	TRUE
ENSG00000070540.13	.	BCM	GRCh38.p13	chr17	68450771	68450774	+	TAAT	TAAT	-	Frame_Shift_Del	DEL	ENST00000262139.10	exon3	c.287_290del	p.N96Tfs*10	exonic	ENSG00000070540.13	.	frameshift deletion	ENSG00000070540.13:ENST00000262139.10:exon3:c.287_290del:p.N96Tfs*10	17q24.2	C3N-04283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WIPI1	125	0	239	37	0.134057971014493	TRUE	TRUE
ENSG00000176293.19	.	BCM	GRCh38.p13	chr19	58067828	58067838	+	CCACAGCTCCT	CCACAGCTCCT	-	Frame_Shift_Del	DEL	ENST00000313434.9	exon5	c.1344_1354del	p.H449Tfs*5	exonic	ENSG00000176293.19	.	frameshift deletion	ENSG00000176293.19:ENST00000313434.9:exon5:c.1344_1354del:p.H449Tfs*5	19q13.43	C3N-04283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF135	551	0	869	47	0.0513100436681223	NA	TRUE
ENSG00000100227.18	.	BCM	GRCh38.p13	chr22	42602919	42602919	+	G	G	C	Missense_Mutation	SNP	ENST00000252115.10	exon2	c.C301G	p.R101G	exonic	ENSG00000100227.18	.	nonsynonymous SNV	ENSG00000100227.18:ENST00000252115.10:exon2:c.C301G:p.R101G	22q13.2	C3N-04283	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	N	D	M	.	D	0.939	T	T	D	0.270	0.418	0.669	0.505	T	T	D	D	D	D	4.079	27.600	0.999	D	D	0.519	5.187	0.517	5.320	1.000	0.707	0.725	0.702	0.714	.	6.080	4.000	5.810	1.176	0.618	1.000	0.992	0.997	232	.	.	.	.	POLDIP3	277	0	542	63	0.104132231404959	TRUE	TRUE
ENSG00000077279.19	.	BCM	GRCh38.p13	chrX	111410134	111410134	+	G	G	A	Nonsense_Mutation	SNP	ENST00000635795.1	exon2	c.C265T	p.R89X	exonic	ENSG00000077279.19	.	stopgain	ENSG00000077279.19:ENST00000635795.1:exon2:c.C265T:p.R89X	Xq23	C3N-04283	.	.	.	.	.	.	.	.	rs104894785	5.5	.	.	.	.	D	A	.	.	.	0.901	.	.	.	.	.	.	.	.	.	D	D	.	.	5.611	34	0.997	D	.	.	.	.	.	1.000	.	.	.	.	.	5.500	3.720	3.389	0.194	-0.154	1.000	0.993	0.980	900	Doublecortin_domain	.	.	ID=COSV57565612;OCCURENCE=1(breast),1(liver),2(large_intestine),1(prostate)	DCX	180	0	325	45	0.121621621621622	TRUE	TRUE
ENSG00000005884.18	.	BCM	GRCh38.p13	chr17	50075598	50075598	+	G	G	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000005884.18	ENST00000320031.13:exon12:c.1538-1G>C	.	.	17q21.33	C3N-04283	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.051	35	0.994	D	.	1.233	27.090	1.092	26.169	1.000	0.106	0.106	0.084	0.118	0.983	5.540	5.540	6.662	1.176	0.676	1.000	0.894	0.972	817	.	.	.	.	ITGA3	223	0	464	75	0.139146567717996	TRUE	TRUE
ENSG00000162761.14	.	BCM	GRCh38.p13	chr1	165210702	165210702	+	C	C	T	Silent	SNP	ENST00000342310.7	exon6	c.G744A	p.A248A	exonic	ENSG00000162761.14	.	synonymous SNV	ENSG00000162761.14:ENST00000342310.7:exon6:c.G744A:p.A248A	1q23.3	C3N-04283	0.0009	9.626e-05	0.0003	0	0.0002	0.0012	0.0022	0.0013	rs146395249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54217285;OCCURENCE=1(skin),1(prostate)	LMX1A	107	0	165	18	0.0983606557377049	TRUE	TRUE
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237503436	237503436	+	C	C	T	Silent	SNP	ENST00000366574.7	exon22	c.C2544T	p.R848R	exonic	ENSG00000198626.17	.	synonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon22:c.C2544T:p.R848R	1q43	C3N-04283	2.485e-05	0	0	0	0	4.496e-05	0	0	rs748097250	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63683700;OCCURENCE=1(biliary_tract),1(stomach),1(haematopoietic_and_lymphoid_tissue),1(pancreas)	RYR2	171	0	362	41	0.101736972704715	TRUE	TRUE
ENSG00000214021.16	.	BCM	GRCh38.p13	chr3	9820697	9820697	+	C	C	T	Silent	SNP	ENST00000426895.9	exon7	c.C1110T	p.P370P	exonic	ENSG00000214021.16;ENSG00000250151.9	.	synonymous SNV	ENSG00000214021.16:ENST00000426895.9:exon7:c.C1110T:p.P370P,ENSG00000250151.9:ENST00000397256.5:exon8:c.C864T:p.P288P	3p25.3	C3N-04283	1.648e-05	0	8.645e-05	0	0	1.499e-05	0	0	rs753309450	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TTLL3	200	0	325	55	0.144736842105263	TRUE	NA
ENSG00000163788.14	.	BCM	GRCh38.p13	chr3	43347810	43347810	+	T	T	G	Silent	SNP	ENST00000296088.12	exon7	c.T1551G	p.A517A	exonic	ENSG00000163788.14	.	synonymous SNV	ENSG00000163788.14:ENST00000296088.12:exon7:c.T1551G:p.A517A	3p22.1	C3N-04283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SNRK	185	0	261	43	0.141447368421053	TRUE	TRUE
ENSG00000250673.2	.	BCM	GRCh38.p13	chr4	146228433	146228433	+	G	G	A	Silent	SNP	ENST00000636502.1	exon5	c.G819A	p.P273P	exonic	ENSG00000250673.2	.	synonymous SNV	ENSG00000250673.2:ENST00000636502.1:exon5:c.G819A:p.P273P	4q31.22	C3N-04283	9.275e-05	0	0	0	.	0	0	0.0001	rs746377000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV73413687;OCCURENCE=1(breast)	REELD1	320	0	589	70	0.106221547799697	TRUE	NA
ENSG00000146360.8	.	BCM	GRCh38.p13	chr6	109979397	109979397	+	G	G	A	Silent	SNP	ENST00000275169.4	exon1	c.G285A	p.A95A	exonic	ENSG00000146360.8	.	synonymous SNV	ENSG00000146360.8:ENST00000275169.4:exon1:c.G285A:p.A95A	6q21	C3N-04283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51574292;OCCURENCE=1(ovary)	GPR6	577	0	810	107	0.116684841875682	TRUE	TRUE
ENSG00000198010.12	.	BCM	GRCh38.p13	chr8	1565784	1565784	+	C	C	T	Silent	SNP	ENST00000421627.7	exon6	c.C1329T	p.D443D	exonic	ENSG00000198010.12	.	synonymous SNV	ENSG00000198010.12:ENST00000421627.7:exon6:c.C1329T:p.D443D	8p23.3	C3N-04283	4.237e-05	0.0003	0	0	0	3.065e-05	0	0	rs371842482	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV70102294;OCCURENCE=1(large_intestine),2(stomach),1(kidney)	DLGAP2	223	0	330	45	0.12	TRUE	TRUE
ENSG00000005884.18	.	BCM	GRCh38.p13	chr17	50075732	50075732	+	G	G	A	Silent	SNP	ENST00000320031.13	exon12	c.G1671A	p.L557L	exonic	ENSG00000005884.18	.	synonymous SNV	ENSG00000005884.18:ENST00000320031.13:exon12:c.G1671A:p.L557L	17q21.33	C3N-04283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITGA3	161	0	308	36	0.104651162790698	TRUE	TRUE
ENSG00000142156.15	.	BCM	GRCh38.p13	chr21	45998433	45998433	+	C	C	T	Silent	SNP	ENST00000361866.8	exon24	c.C1611T	p.N537N	exonic	ENSG00000142156.15	.	synonymous SNV	ENSG00000142156.15:ENST00000361866.8:exon24:c.C1611T:p.N537N	21q22.3	C3N-04283	0.0003	0	0	0	0.0005	0.0004	0	0	rs200023632	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL6A1	354	0	534	47	0.080895008605852	TRUE	NA
ENSG00000100346.18	.	BCM	GRCh38.p13	chr22	39684357	39684357	+	C	C	T	Silent	SNP	ENST00000402142.4	exon36	c.C5886T	p.A1962A	exonic	ENSG00000100346.18	.	synonymous SNV	ENSG00000100346.18:ENST00000402142.4:exon36:c.C5886T:p.A1962A	22q13.1	C3N-04283	.	.	.	.	.	.	.	.	rs929240706	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA1I	497	0	883	116	0.116116116116116	TRUE	NA
ENSG00000185386.15	.	BCM	GRCh38.p13	chr22	50267016	50267016	+	G	G	A	Silent	SNP	ENST00000330651.11	exon7	c.C528T	p.D176D	exonic	ENSG00000185386.15	.	synonymous SNV	ENSG00000185386.15:ENST00000330651.11:exon7:c.C528T:p.D176D	22q13.33	C3N-04283	1.669e-05	9.798e-05	0	0.0001	0	0	0	0	rs200171398	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAPK11	165	0	336	35	0.0943396226415094	TRUE	NA
ENSG00000169933.15	.	BCM	GRCh38.p13	chrX	12717730	12717730	+	G	G	A	Silent	SNP	ENST00000380682.5	exon16	c.G2904A	p.S968S	exonic	ENSG00000169933.15	.	synonymous SNV	ENSG00000169933.15:ENST00000380682.5:exon16:c.G2904A:p.S968S	Xp22.2	C3N-04283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66223530;OCCURENCE=1(breast),1(meninges),1(stomach)	FRMPD4	190	0	267	40	0.130293159609121	TRUE	TRUE
ENSG00000009780.15	.	BCM	GRCh38.p13	chr1	27760053	27760053	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000009780.15	.	.	.	1p35.3	C3N-04283	0.0005	0.0066	0	0	0	0	0	0.0002	rs575900320	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM76A	109	0	210	20	0.0869565217391304	TRUE	NA
ENSG00000119787.14	.	BCM	GRCh38.p13	chr2	38296521	38296521	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000119787.14	.	.	.	2p22.2	C3N-04283	.	.	.	.	.	.	.	.	.	7.17	T	T	B	B	.	D	.	D	N	0.356	T	D	D	0.261	0.203	0.775	.	.	T	D	T	T	T	2.018	19.390	0.943	D	D	-0.136	2.063	0.080	2.655	1.000	0.707	0.654	0.725	0.636	.	5.320	5.320	3.921	1.176	0.676	1.000	1.000	0.999	830	.	.	.	.	ATL2	183	0	252	26	0.0935251798561151	TRUE	TRUE
ENSG00000153094.24	.	BCM	GRCh38.p13	chr2	111153803	111153803	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000153094.24	.	.	.	2q13	C3N-04283	.	.	.	.	.	.	.	.	.	0.6	.	.	.	.	.	N	.	.	.	0.086	.	.	.	.	.	0.189	.	.	.	T	T	.	T	0.493	6.434	0.877	N	N	.	.	.	.	1.000	0.651	0.546	0.651	0.221	.	4.310	-7.970	-1.081	-0.704	-0.113	0.010	0.954	0.998	783	.	.	.	.	BCL2L11	157	0	291	31	0.0962732919254658	TRUE	TRUE
ENSG00000272031.3	.	BCM	GRCh38.p13	chr1	145960657	145960657	+	G	G	C	Missense_Mutation	SNP	ENST00000606888.3	exon4	c.C1103G	p.P368R	exonic	ENSG00000272031.3	.	nonsynonymous SNV	ENSG00000272031.3:ENST00000606888.3:exon4:c.C1103G:p.P368R	1q21.1	C3L-02109	.	.	.	.	.	.	.	.	rs781981808	1.4	.	T	.	.	.	.	.	.	.	0.525	.	.	.	.	.	.	.	.	T	.	.	.	T	3.524	24.800	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	4.575	1.176	0.618	1.000	0.998	0.998	958	.	.	.	.	ANKRD34A	47	0	136	40	0.227272727272727	TRUE	NA
ENSG00000143748.18	.	BCM	GRCh38.p13	chr1	224300651	224300651	+	G	G	A	Missense_Mutation	SNP	ENST00000281701.11	exon10	c.C973T	p.P325S	exonic	ENSG00000143748.18	.	nonsynonymous SNV	ENSG00000143748.18:ENST00000281701.11:exon10:c.C973T:p.P325S	1q42.11	C3L-02109	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	L	T	D	0.725	D	D	D	0.720	0.662	0.922	0.941	T	D	D	D	D	D	4.227	28.900	0.999	D	D	0.672	6.742	0.702	7.790	1.000	0.732	0.654	0.744	0.655	.	5.400	5.400	9.744	1.176	0.676	1.000	0.972	0.955	661	ATPase,_AAA-type,_core;AAA+_ATPase_domain	.	.	.	NVL	97	0	216	68	0.23943661971831	TRUE	TRUE
ENSG00000196862.10	.	BCM	GRCh38.p13	chr2	107861683	107861683	+	G	G	T	Missense_Mutation	SNP	ENST00000408999.4	exon15	c.G2148T	p.R716S	exonic	ENSG00000196862.10	.	nonsynonymous SNV	ENSG00000196862.10:ENST00000408999.4:exon15:c.G2148T:p.R716S	2q12.3	C3L-02109	.	.	.	.	.	.	.	.	.	7.19	D	D	B	B	.	N	M	T	D	0.543	T	T	T	0.060	0.374	0.095	.	T	T	T	T	D	D	2.427	22.200	0.972	D	N	-0.285	1.651	-0.290	1.586	0.000	0.487	0.574	0.574	0.564	.	2.600	1.520	0.410	1.061	0.302	0.998	0.999	0.797	963	.	.	.	.	RGPD4	140	0	195	24	0.10958904109589	NA	TRUE
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	141188568	141188568	+	G	G	A	Missense_Mutation	SNP	ENST00000389484.8	exon7	c.C866T	p.A289V	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon7:c.C866T:p.A289V	2q22.1	C3L-02109	3.323e-05	0	0	0.0001	0	0	0	0.0002	rs762658862	17.20	T	D	D	D	U	D	M	D	D	0.919	D	D	D	0.818	0.650	0.459	0.413	T	D	D	D	D	D	4.189	28.600	0.999	D	D	0.838	9.580	0.825	10.920	1.000	0.487	0.574	0.574	0.564	.	5.200	5.200	9.663	0.225	0.676	1.000	0.958	0.998	652	.	.	.	.	LRP1B	112	0	201	30	0.12987012987013	TRUE	NA
ENSG00000115806.13	.	BCM	GRCh38.p13	chr2	170965810	170965810	+	A	A	T	Missense_Mutation	SNP	ENST00000234160.5	exon10	c.A1039T	p.M347L	exonic	ENSG00000115806.13	.	nonsynonymous SNV	ENSG00000115806.13:ENST00000234160.5:exon10:c.A1039T:p.M347L	2q31.1	C3L-02109	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.107	T	T	T	0.026	0.361	0.117	0.126	T	T	T	T	T	T	0.868	10.100	0.499	N	N	-1.021	0.383	-0.727	0.861	1.000	0.707	0.702	0.702	0.714	.	5.610	2.000	1.506	-0.137	-0.106	1.000	0.976	0.837	651	.	.	.	.	GORASP2	206	0	427	66	0.133874239350913	TRUE	TRUE
ENSG00000114541.15	.	BCM	GRCh38.p13	chr3	69176548	69176548	+	T	T	C	Missense_Mutation	SNP	ENST00000398540.8	exon22	c.A2960G	p.Y987C	exonic	ENSG00000114541.15	.	nonsynonymous SNV	ENSG00000114541.15:ENST00000398540.8:exon22:c.A2960G:p.Y987C	3p14.1	C3L-02109	8.281e-06	0	0	0	0	1.498e-05	0	0	rs758394679	10.20	D	T	B	B	N	D	M	D	N	0.431	D	D	D	0.531	0.290	0.398	0.061	T	T	T	D	T	D	2.506	22.400	0.985	D	N	0.303	3.794	0.382	4.235	1.000	0.722	0.588	0.659	0.735	.	5.690	5.690	2.268	1.109	0.609	1.000	0.994	0.998	527	.	.	.	ID=COSV101273630;OCCURENCE=1(liver)	FRMD4B	127	0	194	35	0.152838427947598	TRUE	NA
ENSG00000174473.16	.	BCM	GRCh38.p13	chr4	171814690	171814690	+	T	T	C	Missense_Mutation	SNP	ENST00000506823.6	exon2	c.T110C	p.V37A	exonic	ENSG00000174473.16	.	nonsynonymous SNV	ENSG00000174473.16:ENST00000506823.6:exon2:c.T110C:p.V37A	4q34.1	C3L-02109	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	D	N	T	N	0.263	T	T	T	0.130	0.605	0.508	0.596	T	T	T	T	T	T	2.016	19.380	0.916	D	D	-0.186	1.917	0.082	2.661	1.000	0.583	0.563	0.615	0.530	.	5.900	5.900	6.295	1.138	0.665	1.000	0.996	0.914	972	.	.	.	.	GALNTL6	234	0	446	68	0.132295719844358	TRUE	TRUE
ENSG00000112941.14	.	BCM	GRCh38.p13	chr5	6737622	6737622	+	C	C	T	Missense_Mutation	SNP	ENST00000230859.8	exon2	c.C829T	p.P277S	exonic	ENSG00000112941.14	.	nonsynonymous SNV	ENSG00000112941.14:ENST00000230859.8:exon2:c.C829T:p.P277S	5p15.31	C3L-02109	.	.	.	.	.	.	.	.	.	11.14	.	D	.	.	D	D	.	.	D	0.764	T	T	D	0.469	-	0.513	2.243	T	.	D	D	D	D	3.901	26.400	0.999	D	D	0.804	8.859	0.750	8.801	1.000	0.707	0.522	0.725	0.714	.	5.050	5.050	7.114	1.026	0.549	1.000	0.933	0.987	809	Polymerase,_nucleotidyl_transferase_domain	.	.	.	TENT4A	147	0	260	56	0.177215189873418	TRUE	TRUE
ENSG00000039139.9	.	BCM	GRCh38.p13	chr5	13780952	13780952	+	C	C	T	Missense_Mutation	SNP	ENST00000265104.4	exon53	c.G8828A	p.R2943H	exonic	ENSG00000039139.9	.	nonsynonymous SNV	ENSG00000039139.9:ENST00000265104.4:exon53:c.G8828A:p.R2943H	5p15.2	C3L-02109	5.807e-05	0	0	0	0	7.54e-05	0	0.0001	rs184758570	17.19	D	.	D	D	D	D	H	T	D	0.986	D	D	D	0.632	.	0.862	0.444	T	D	D	D	D	D	3.902	26.400	0.999	D	D	1.014	14.379	0.842	11.469	1.000	0.487	0.574	0.574	0.564	.	5.560	5.560	7.811	1.026	0.599	1.000	0.632	0.545	707	Dynein_heavy_chain,_AAA_module_D4	.	.	ID=COSV54203923;OCCURENCE=1(large_intestine),2(pancreas),1(endometrium)	DNAH5	197	0	433	84	0.16247582205029	TRUE	TRUE
ENSG00000275379.2	.	BCM	GRCh38.p13	chr6	27872000	27872000	+	C	C	T	Missense_Mutation	SNP	ENST00000616365.2	exon1	c.G316A	p.E106K	exonic	ENSG00000275379.2	.	nonsynonymous SNV	ENSG00000275379.2:ENST00000616365.2:exon1:c.G316A:p.E106K	6p22.1	C3L-02109	.	.	.	.	.	.	.	.	.	9.11	.	D	.	.	.	D	.	.	.	0.932	T	T	D	0.650	.	0.601	.	D	.	D	D	D	.	3.483	24.700	0.992	D	D	0.377	4.206	0.396	4.329	1.000	0.243	0.219	0.391	0.250	.	4.120	4.120	7.701	1.022	0.596	1.000	0.734	0.723	485	.	.	.	ID=COSV100137683;OCCURENCE=1(upper_aerodigestive_tract)	H3C11	254	0	480	61	0.11275415896488	TRUE	TRUE
ENSG00000112218.9	.	BCM	GRCh38.p13	chr6	96798938	96798938	+	A	A	G	Missense_Mutation	SNP	ENST00000229955.4	exon2	c.T794C	p.I265T	exonic	ENSG00000112218.9	.	nonsynonymous SNV	ENSG00000112218.9:ENST00000229955.4:exon2:c.T794C:p.I265T	6q16.1	C3L-02109	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.932	T	T	D	0.774	0.871	0.668	0.589	D	T	D	D	D	D	3.880	26.200	0.998	D	D	0.848	9.788	0.805	10.283	1.000	0.719	0.654	0.723	0.564	.	5.200	5.200	8.947	1.312	0.756	1.000	1.000	1.000	754	GPCR,_rhodopsin-like,_7TM	.	.	.	GPR63	287	0	584	62	0.0959752321981424	TRUE	TRUE
ENSG00000130023.16	.	BCM	GRCh38.p13	chr6	169773388	169773388	+	C	C	G	Missense_Mutation	SNP	ENST00000366773.8	exon13	c.C1303G	p.Q435E	exonic	ENSG00000130023.16	.	nonsynonymous SNV	ENSG00000130023.16:ENST00000366773.8:exon13:c.C1303G:p.Q435E	6q27	C3L-02109	.	.	.	.	.	.	.	.	.	2.19	D	T	P	B	N	N	L	T	N	0.402	T	T	T	0.060	0.351	0.292	0.057	.	T	T	T	T	D	1.272	14.180	0.525	N	N	-0.469	1.239	-0.526	1.160	0.079	0.707	0.725	0.659	0.684	.	5.180	4.310	1.664	0.980	0.599	0.155	0.700	0.004	929	.	.	.	.	ERMARD	134	0	194	22	0.101851851851852	TRUE	TRUE
ENSG00000105989.10	.	BCM	GRCh38.p13	chr7	117278346	117278346	+	A	A	G	Missense_Mutation	SNP	ENST00000265441.8	exon5	c.T892C	p.S298P	exonic	ENSG00000105989.10	.	nonsynonymous SNV	ENSG00000105989.10:ENST00000265441.8:exon5:c.T892C:p.S298P	7q31.2	C3L-02109	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.823	D	D	D	0.900	0.611	0.725	0.983	T	D	D	D	D	D	4.314	29.700	0.999	D	D	0.993	13.691	0.939	15.534	1.000	0.554	0.588	0.574	0.621	.	5.870	5.870	9.325	1.312	0.756	1.000	0.999	0.990	425	.	.	.	.	WNT2	168	0	394	68	0.147186147186147	TRUE	TRUE
ENSG00000165113.13	.	BCM	GRCh38.p13	chr9	83799190	83799190	+	C	C	T	Missense_Mutation	SNP	ENST00000376371.7	exon4	c.G355A	p.E119K	exonic	ENSG00000165113.13	.	nonsynonymous SNV	ENSG00000165113.13:ENST00000376371.7:exon4:c.G355A:p.E119K	9q21.32	C3L-02109	2.471e-05	0	0	0	0	0	0	0.0002	rs767081495	7.19	T	T	P	B	D	D	L	.	N	0.790	T	T	T	0.218	0.207	0.416	0.158	T	T	D	D	T	D	2.883	23.200	0.998	D	D	0.305	3.807	0.434	4.606	1.000	0.638	0.634	0.653	0.568	.	5.290	5.290	6.911	1.022	0.596	1.000	1.000	0.999	968	.	.	.	.	GKAP1	229	0	321	32	0.0906515580736544	TRUE	NA
ENSG00000127084.19	.	BCM	GRCh38.p13	chr9	93029995	93029995	+	C	C	A	Missense_Mutation	SNP	ENST00000375482.8	exon15	c.C1679A	p.A560E	exonic	ENSG00000127084.19	.	nonsynonymous SNV	ENSG00000127084.19:ENST00000375482.8:exon15:c.C1679A:p.A560E	9q22.31	C3L-02109	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.250	T	T	T	0.161	0.553	0.309	0.470	T	T	T	T	T	T	0.489	6.389	0.428	D	N	-1.025	0.378	-1.008	0.479	1.000	0.707	0.725	0.602	0.613	.	4.310	-1.100	0.609	-3.210	-1.642	0.492	0.014	0.048	970	FYVE_zinc_finger;Zinc_finger,_FYVE-related	.	.	.	FGD3	91	0	146	25	0.146198830409357	TRUE	TRUE
ENSG00000136931.10	.	BCM	GRCh38.p13	chr9	124500442	124500442	+	A	A	G	Missense_Mutation	SNP	ENST00000373588.9	exon4	c.T518C	p.V173A	exonic	ENSG00000136931.10	.	nonsynonymous SNV	ENSG00000136931.10:ENST00000373588.9:exon4:c.T518C:p.V173A	9q33.3	C3L-02109	.	.	.	.	.	.	.	.	.	6.20	D	T	B	B	N	N	L	D	N	0.365	T	D	D	0.403	0.537	0.846	1.099	T	T	T	T	T	T	1.486	15.650	0.975	D	D	-0.493	1.190	-0.475	1.242	1.000	0.497	0.578	0.578	0.542	.	4.950	3.800	4.031	1.312	0.756	0.998	0.352	0.646	702	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	NR5A1	170	0	397	64	0.13882863340564	TRUE	TRUE
ENSG00000095585.17	.	BCM	GRCh38.p13	chr10	96271385	96271385	+	T	T	C	Missense_Mutation	SNP	ENST00000224337.10	exon1	c.A14G	p.N5S	exonic	ENSG00000095585.17	.	nonsynonymous SNV	ENSG00000095585.17:ENST00000224337.10:exon1:c.A14G:p.N5S	10q24.1	C3L-02109	.	.	.	.	.	.	.	.	.	8.19	D	D	D	D	D	D	L	.	N	0.495	T	T	T	0.139	0.275	0.647	0.906	T	T	T	T	D	D	2.365	21.900	0.984	N	N	0.432	4.549	0.470	4.893	1.000	0.487	0.522	0.574	0.542	.	5.800	5.800	2.609	1.138	0.665	1.000	1.000	0.997	447	.	.	.	.	BLNK	241	0	360	64	0.150943396226415	TRUE	TRUE
ENSG00000107815.10	.	BCM	GRCh38.p13	chr10	100988320	100988320	+	G	G	A	Missense_Mutation	SNP	ENST00000311916.8	exon1	c.G110A	p.R37H	exonic	ENSG00000107815.10	.	nonsynonymous SNV	ENSG00000107815.10:ENST00000311916.8:exon1:c.G110A:p.R37H	10q24.31	C3L-02109	.	.	.	.	.	.	.	.	.	6.19	T	T	B	B	D	D	L	D	N	0.173	D	D	D	0.279	0.248	0.461	0.679	.	T	T	T	T	T	1.787	17.640	0.989	N	N	-0.477	1.222	-0.367	1.433	1.000	0.628	0.672	0.686	0.628	.	5.590	4.680	0.896	1.166	0.665	0.198	0.658	0.023	552	.	.	.	.	TWNK	364	0	732	115	0.135773317591499	TRUE	TRUE
ENSG00000215009.5	.	BCM	GRCh38.p13	chr12	7306678	7306678	+	G	G	A	Missense_Mutation	SNP	ENST00000399422.4	exon2	c.G347A	p.R116H	exonic	ENSG00000215009.5	.	nonsynonymous SNV	ENSG00000215009.5:ENST00000399422.4:exon2:c.G347A:p.R116H	12p13.31	C3L-02109	6.699e-05	0.0001	0.0001	0	0.0002	1.974e-05	0	0.0002	rs370415520	4.20	T	T	P	B	N	N	M	T	D	0.316	T	T	T	0.161	.	0.288	0.462	T	T	T	T	T	T	2.069	19.780	0.990	D	D	-0.039	2.376	-0.063	2.157	0.005	0.487	0.574	0.574	0.530	.	4.890	3.990	5.279	0.210	-0.119	1.000	0.349	0.196	670	AMP-dependent_synthetase/ligase	.	.	.	ACSM4	274	0	529	100	0.158982511923688	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3L-02109	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	241	0	376	65	0.147392290249433	TRUE	TRUE
ENSG00000135519.8	.	BCM	GRCh38.p13	chr12	49550320	49550320	+	G	G	A	Missense_Mutation	SNP	ENST00000257981.7	exon10	c.G1909A	p.A637T	exonic	ENSG00000135519.8	.	nonsynonymous SNV	ENSG00000135519.8:ENST00000257981.7:exon10:c.G1909A:p.A637T	12q13.12	C3L-02109	.	.	.	.	.	.	.	.	.	17.20	D	D	P	P	D	D	H	D	D	0.670	D	D	D	0.738	0.533	0.950	2.277	T	D	D	D	D	D	4.382	31	0.999	D	D	0.905	11.183	0.890	13.323	1.000	0.677	0.627	0.673	0.563	.	5.480	5.480	9.968	1.176	0.676	1.000	1.000	0.999	180	Cyclic_nucleotide-binding_domain	.	.	ID=COSV57789775;OCCURENCE=3(large_intestine),1(upper_aerodigestive_tract)	KCNH3	49	0	176	37	0.173708920187793	TRUE	TRUE
ENSG00000135476.12	.	BCM	GRCh38.p13	chr12	53289504	53289504	+	C	C	T	Missense_Mutation	SNP	ENST00000257934.9	exon22	c.C5023T	p.R1675C	exonic	ENSG00000135476.12	.	nonsynonymous SNV	ENSG00000135476.12:ENST00000257934.9:exon22:c.C5023T:p.R1675C	12q13.13	C3L-02109	.	.	.	.	.	.	.	.	.	5.20	T	D	B	B	N	D	L	T	D	0.128	T	T	T	0.104	0.448	0.273	1.076	T	T	T	T	D	T	2.206	20.900	0.993	D	N	-0.342	1.514	-0.178	1.839	1.000	0.722	0.725	0.725	0.735	.	5.260	4.370	0.227	1.022	0.596	0.349	0.954	0.977	696	.	.	.	ID=COSV57761590;OCCURENCE=1(stomach)	ESPL1	155	0	350	56	0.137931034482759	TRUE	TRUE
ENSG00000069869.16	.	BCM	GRCh38.p13	chr15	55830555	55830555	+	T	T	-	Frame_Shift_Del	NA	ENST00000508342.5	exon24	c.3816delA	p.E1272Dfs*64	exonic	ENSG00000069869.16	.	frameshift deletion	ENSG00000069869.16:ENST00000508342.5:exon24:c.3816delA:p.E1272Dfs*64	15q21.3	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEDD4	225	0	377	37	0.0893719806763285	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673776	7673776	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.C844T	p.R282W	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.C844T:p.R282W	17p13.1	C3L-02109	1.659e-05	0	0	0	0	3.014e-05	0	0	rs28934574	19.20	D	D	D	D	D	A	M	D	D	0.932	D	D	D	0.896	.	0.980	0.392	T	D	D	D	D	D	4.401	31	0.999	D	D	0.395	4.315	0.222	3.292	0.203	0.722	0.702	0.725	0.735	.	4.750	1.490	4.023	1.172	0.672	1.000	0.519	0.997	432	p53,_DNA-binding_domain	.	.	ID=COSV52662048;OCCURENCE=1(salivary_gland),52(breast),2(peritoneum),6(liver),92(oesophagus),1(cervix),279(large_intestine),54(central_nervous_system),12(biliary_tract),1(pleura),6(vulva),25(ovary),3(bone),2(NS),20(haematopoietic_and_lymphoid_tissue),64(stomach),5(kidney),3(soft_tissue),22(urinary_tract),48(pancreas),21(skin),21(prostate),38(lung),6(thyroid),78(upper_aerodigestive_tract),3(thymus),3(small_intestine),13(endometrium)	TP53	500	0	924	161	0.148387096774194	TRUE	TRUE
ENSG00000141750.7	.	BCM	GRCh38.p13	chr17	39213557	39213557	+	G	G	A	Missense_Mutation	SNP	ENST00000333461.6	exon9	c.C943T	p.P315S	exonic	ENSG00000141750.7	.	nonsynonymous SNV	ENSG00000141750.7:ENST00000333461.6:exon9:c.C943T:p.P315S	17q12	C3L-02109	.	.	.	.	.	.	.	.	.	11.20	D	T	D	D	D	D	L	T	D	0.674	T	T	D	0.409	0.355	0.812	0.572	T	T	T	T	D	D	4.767	33	0.999	D	D	0.743	7.763	0.718	8.094	1.000	0.696	0.590	0.723	0.542	.	4.870	4.870	8.438	1.083	0.671	1.000	0.998	0.934	591	Stac2,_SH3_domain;SH3_domain	.	.	.	STAC2	149	0	294	48	0.140350877192982	TRUE	TRUE
ENSG00000167914.12	.	BCM	GRCh38.p13	chr17	39974949	39974949	+	C	C	G	Missense_Mutation	SNP	ENST00000301659.9	exon10	c.C956G	p.P319R	exonic	ENSG00000167914.12	.	nonsynonymous SNV	ENSG00000167914.12:ENST00000301659.9:exon10:c.C956G:p.P319R	17q21.1	C3L-02109	.	.	.	.	.	.	.	.	.	5.20	T	D	D	P	D	N	N	T	N	0.637	T	T	T	0.228	0.509	0.370	0.435	T	T	T	T	D	T	3.211	23.900	0.993	D	N	0.115	2.945	0.106	2.761	1.000	0.447	0.547	0.547	0.530	.	6.030	5.060	3.599	1.026	0.599	0.993	0.855	0.291	269	.	.	.	.	GSDMA	140	0	302	54	0.151685393258427	TRUE	TRUE
ENSG00000141447.18	.	BCM	GRCh38.p13	chr18	24172393	24172393	+	-	NA	ACATTGCCAT	Frame_Shift_Ins	INS	ENST00000319481.8	exon22	c.2183_2184insATGGCAATGT	p.E729Wfs*19	exonic	ENSG00000141447.18	.	frameshift insertion	ENSG00000141447.18:ENST00000319481.8:exon22:c.2183_2184insATGGCAATGT:p.E729Wfs*19	18q11.2	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OSBPL1A	NA	NA	NA	NA	NA	NA	NA
ENSG00000125735.10	.	BCM	GRCh38.p13	chr19	6665150	6665150	+	A	A	G	Missense_Mutation	SNP	ENST00000599359.1	exon5	c.T499C	p.Y167H	exonic	ENSG00000125735.10	.	nonsynonymous SNV	ENSG00000125735.10:ENST00000599359.1:exon5:c.T499C:p.Y167H	19p13.3	C3L-02109	.	.	.	.	.	.	.	.	.	15.18	.	D	D	D	N	D	M	D	.	0.301	D	D	D	0.747	0.684	0.941	1.237	T	D	D	D	D	T	3.839	26.000	0.998	D	D	0.557	5.508	0.502	5.173	0.999	0.461	0.577	0.573	0.613	.	4.500	4.500	2.932	1.202	0.751	0.965	0.996	0.933	940	Tumour_necrosis_factor_domain	.	.	.	TNFSF14	91	0	307	41	0.117816091954023	TRUE	TRUE
ENSG00000181143.15	.	BCM	GRCh38.p13	chr19	8856003	8856003	+	G	G	A	Missense_Mutation	SNP	ENST00000397910.8	exon81	c.C43274T	p.T14425I	exonic	ENSG00000181143.15	.	nonsynonymous SNV	ENSG00000181143.15:ENST00000397910.8:exon81:c.C43274T:p.T14425I	19p13.2	C3L-02109	.	.	.	.	.	.	.	.	.	6.15	D	D	.	.	.	N	.	T	D	0.372	T	T	D	0.270	.	0.158	.	T	.	T	T	D	T	2.807	23.000	0.999	D	N	0.411	4.415	0.330	3.896	0.000	0.554	0.574	0.602	0.564	.	4.220	3.170	1.028	1.146	0.674	0.998	0.992	0.956	958	SEA_domain	.	.	.	MUC16	183	0	332	69	0.172069825436409	TRUE	TRUE
ENSG00000243137.8	.	BCM	GRCh38.p13	chr19	43193386	43193386	+	A	A	T	Missense_Mutation	SNP	ENST00000405312.8	exon6	c.T1246A	p.W416R	exonic	ENSG00000243137.8	.	nonsynonymous SNV	ENSG00000243137.8:ENST00000405312.8:exon6:c.T1246A:p.W416R	19q13.31	C3L-02109	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.210	T	T	T	0.013	0.383	0.095	0.005	T	T	T	T	T	T	1.223	13.810	0.260	N	N	-1.269	0.183	-1.358	0.174	0.000	0.487	0.574	0.547	0.564	.	0.100	0.100	0.200	0.228	0.229	0.257	0.340	0.329	809	.	.	.	.	PSG4	353	0	479	55	0.102996254681648	NA	TRUE
ENSG00000243137.8	.	BCM	GRCh38.p13	chr19	43194394	43194394	+	G	G	A	Missense_Mutation	SNP	ENST00000405312.8	exon5	c.C1189T	p.R397C	exonic	ENSG00000243137.8	.	nonsynonymous SNV	ENSG00000243137.8:ENST00000405312.8:exon5:c.C1189T:p.R397C	19q13.31	C3L-02109	1.648e-05	0.0002	0	0	0	0	0	0	rs138668740	8.19	D	D	D	D	.	N	M	T	D	0.114	T	T	T	0.026	.	0.175	0.023	T	T	T	T	D	D	1.941	18.810	0.996	N	N	-0.289	1.640	-0.647	0.977	0.000	0.554	0.574	0.547	0.621	.	1.180	-0.485	-0.119	0.624	0.240	0.000	0.001	0.014	814	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV54937332;OCCURENCE=1(NS),1(skin)	PSG4	288	0	445	51	0.102822580645161	NA	TRUE
ENSG00000124089.4	.	BCM	GRCh38.p13	chr20	56249398	56249398	+	C	C	A	Missense_Mutation	SNP	ENST00000243911.2	exon1	c.C555A	p.S185R	exonic	ENSG00000124089.4	.	nonsynonymous SNV	ENSG00000124089.4:ENST00000243911.2:exon1:c.C555A:p.S185R	20q13.2	C3L-02109	.	.	.	.	.	.	.	.	.	11.18	D	T	.	.	D	D	M	T	D	0.835	T	T	T	0.256	.	0.752	0.709	T	T	D	D	D	D	3.115	23.700	0.998	D	D	0.540	5.366	0.502	5.173	1.000	0.526	0.616	0.596	0.584	.	5.370	4.430	3.133	1.026	0.599	1.000	1.000	0.995	982	GPCR,_rhodopsin-like,_7TM	.	.	.	MC3R	439	0	911	134	0.12822966507177	TRUE	TRUE
ENSG00000089472.16	.	BCM	GRCh38.p13	chrX	66172549	66172549	+	G	G	T	Missense_Mutation	SNP	ENST00000343002.6	exon2	c.G362T	p.R121L	exonic	ENSG00000089472.16	.	nonsynonymous SNV	ENSG00000089472.16:ENST00000343002.6:exon2:c.G362T:p.R121L	Xq12	C3L-02109	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	M	D	D	0.795	D	D	D	0.944	0.606	0.655	0.502	T	D	D	D	D	D	3.958	26.700	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.830	4.830	9.893	1.176	0.676	1.000	0.990	0.995	728	Multicopper_oxidase,_type_3	.	.	ID=COSV100294341;OCCURENCE=1(stomach)	HEPH	75	0	189	28	0.129032258064516	TRUE	NA
ENSG00000102081.15	.	BCM	GRCh38.p13	chrX	147948803	147948803	+	A	A	G	Missense_Mutation	SNP	ENST00000370475.9	exon17	c.A1858G	p.S620G	exonic	ENSG00000102081.15	.	nonsynonymous SNV	ENSG00000102081.15:ENST00000370475.9:exon17:c.A1858G:p.S620G	Xq27.3	C3L-02109	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	D	N	T	N	0.136	T	T	T	0.075	0.068	0.618	0.812	T	T	T	T	T	D	1.590	16.310	0.970	N	.	.	.	.	.	0.019	.	.	.	.	.	5.610	1.960	1.791	0.325	0.756	1.000	0.996	0.995	728	Fragile_X-related_mental_retardation_protein,_C-terminal_region_2	.	.	.	FMR1	262	0	503	81	0.138698630136986	TRUE	TRUE
ENSG00000124334.17	.	BCM	GRCh38.p13	chrX	156005428	156005428	+	C	C	T	Nonsense_Mutation	SNP	ENST00000244174.10	exon6	c.C730T	p.Q244X	exonic	ENSG00000124334.17	.	stopgain	ENSG00000124334.17:ENST00000244174.10:exon6:c.C730T:p.Q244X	Xq28	C3L-02109	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	N	A	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.705	36	0.986	N	.	.	.	.	.	0.989	.	.	.	.	.	1.290	1.290	1.720	0.687	0.450	0.884	0.334	0.135	.	Fibronectin_type_III;Short_hematopoietin_receptor,_family_1,_conserved_site	.	.	.	IL9R	367	0	767	85	0.0997652582159624	TRUE	TRUE
ENSG00000070759.17	.	BCM	GRCh38.p13	chr1	45344894	45344894	+	G	G	C	Silent	SNP	ENST00000372086.4	exon11	c.C1662G	p.A554A	exonic	ENSG00000070759.17	.	synonymous SNV	ENSG00000070759.17:ENST00000372086.4:exon11:c.C1662G:p.A554A	1p34.1	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TESK2	136	0	289	43	0.129518072289157	TRUE	TRUE
ENSG00000152990.14	.	BCM	GRCh38.p13	chr4	22388758	22388758	+	A	A	G	Silent	SNP	ENST00000334304.10	exon19	c.T2913C	p.N971N	exonic	ENSG00000152990.14	.	synonymous SNV	ENSG00000152990.14:ENST00000334304.10:exon19:c.T2913C:p.N971N	4p15.2	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADGRA3	325	1	608	68	0.100591715976331	TRUE	TRUE
ENSG00000146090.16	.	BCM	GRCh38.p13	chr5	180137668	180137668	+	G	G	A	Silent	SNP	ENST00000361132.9	exon3	c.C222T	p.I74I	exonic	ENSG00000146090.16	.	synonymous SNV	ENSG00000146090.16:ENST00000361132.9:exon3:c.C222T:p.I74I	5q35.3	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RASGEF1C	228	1	621	105	0.144628099173554	TRUE	NA
ENSG00000133116.8	.	BCM	GRCh38.p13	chr13	33016503	33016503	+	G	G	A	Silent	SNP	ENST00000380099.4	exon1	c.G63A	p.L21L	exonic	ENSG00000133116.8	.	synonymous SNV	ENSG00000133116.8:ENST00000380099.4:exon1:c.G63A:p.L21L	13q13.1	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KL	26	0	64	13	0.168831168831169	TRUE	TRUE
ENSG00000125124.12	.	BCM	GRCh38.p13	chr16	56502355	56502355	+	G	G	A	Silent	SNP	ENST00000245157.10	exon9	c.C1042T	p.L348L	exonic	ENSG00000125124.12	.	synonymous SNV	ENSG00000125124.12:ENST00000245157.10:exon9:c.C1042T:p.L348L	16q13	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BBS2	459	0	844	139	0.141403865717192	TRUE	NA
ENSG00000011332.19	.	BCM	GRCh38.p13	chr19	38216249	38216249	+	C	C	T	Silent	SNP	ENST00000420980.6	exon8	c.G738A	p.A246A	exonic	ENSG00000011332.19	.	synonymous SNV	ENSG00000011332.19:ENST00000420980.6:exon8:c.G738A:p.A246A	19q13.2	C3L-02109	0.0001	0.0011	0.0002	0	0	4.524e-05	0	6.124e-05	rs148078050	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DPF1	68	0	163	25	0.132978723404255	TRUE	NA
ENSG00000197380.11	.	BCM	GRCh38.p13	chr19	46649466	46649466	+	C	C	T	Silent	SNP	ENST00000391916.7	exon4	c.G906A	p.A302A	exonic	ENSG00000197380.11	.	synonymous SNV	ENSG00000197380.11:ENST00000391916.7:exon4:c.G906A:p.A302A	19q13.32	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DACT3	22	0	100	19	0.159663865546218	TRUE	TRUE
ENSG00000197586.13	.	BCM	GRCh38.p13	chr20	25225540	25225540	+	G	G	A	Silent	SNP	ENST00000376652.9	exon15	c.G1398A	p.L466L	exonic	ENSG00000197586.13	.	synonymous SNV	ENSG00000197586.13:ENST00000376652.9:exon15:c.G1398A:p.L466L	20p11.21	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ENTPD6	83	0	172	26	0.131313131313131	TRUE	TRUE
ENSG00000100053.10	.	BCM	GRCh38.p13	chr22	25202715	25202715	+	C	C	T	Silent	SNP	ENST00000215855.7	exon3	c.C117T	p.C39C	exonic	ENSG00000100053.10	.	synonymous SNV	ENSG00000100053.10:ENST00000215855.7:exon3:c.C117T:p.C39C	22q11.23	C3L-02109	8.3e-06	0	0	0	0	1.513e-05	0	0	rs764774270	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53194520;OCCURENCE=1(breast)	CRYBB3	498	0	1064	124	0.104377104377104	TRUE	TRUE
ENSG00000165370.2	.	BCM	GRCh38.p13	chrX	137031582	137031582	+	G	G	T	Silent	SNP	ENST00000651716.1	exon2	c.C93A	p.G31G	exonic	ENSG00000165370.2	.	synonymous SNV	ENSG00000165370.2:ENST00000651716.1:exon2:c.C93A:p.G31G	Xq26.3	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPR101	118	0	193	27	0.122727272727273	TRUE	TRUE
ENSG00000126890.13	.	BCM	GRCh38.p13	chrX	154653405	154653405	+	C	C	T	Silent	SNP	ENST00000247306.4	exon1	c.G111A	p.A37A	exonic	ENSG00000126890.13	.	synonymous SNV	ENSG00000126890.13:ENST00000247306.4:exon1:c.G111A:p.A37A	Xq28	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55996300;OCCURENCE=1(oesophagus)	CTAG2	106	0	345	40	0.103896103896104	NA	TRUE
ENSG00000198169.9	.	BCM	GRCh38.p13	chr8	144753658	144753658	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000198169.9	.	.	.	8q24.3	C3L-02109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF251	79	0	199	22	0.0995475113122172	TRUE	NA
ENSG00000165406.16	.	BCM	GRCh38.p13	chr10	45463670	45463670	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000165406.16	.	.	.	10q11.21	C3L-02109	.	.	.	.	.	.	.	.	rs564144489	0.9	.	T	.	.	.	N	.	.	.	0.113	.	.	T	.	.	0.344	.	T	.	T	T	.	T	1.007	11.720	0.713	N	N	.	.	.	.	1.000	0.493	0.587	0.602	0.492	.	5.510	1.340	1.611	0.227	-0.119	0.945	0.038	0.031	824	.	.	.	.	MARCHF8	277	0	389	57	0.12780269058296	TRUE	NA
ENSG00000129514.8	.	BCM	GRCh38.p13	chr14	37622851	37622851	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000129514.8;ENSG00000200385.1	dist=27602;dist=97574	.	.	14q21.1	C3L-02109	.	.	.	.	.	.	.	.	.	1.14	T	T	.	.	N	.	.	T	N	0.105	T	T	D	0.055	0.312	0.298	0.032	.	T	T	T	T	T	-0.042	1.092	0.984	N	.	-0.842	0.596	-0.974	0.522	1.000	0.623	0.574	0.378	0.555	.	3.980	-0.812	-0.757	1.071	0.526	0.000	0.001	0.004	682	.	.	.	ID=COSV101606840;OCCURENCE=1(stomach)	FOXA1	113	1	259	32	0.109965635738832	TRUE	TRUE
ENSG00000252608.1	.	BCM	GRCh38.p13	chr16	81149863	81149863	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000252608.1;ENSG00000286759.1	dist=43224;dist=1957	.	.	16q23.2	C3L-02109	0.0058	0.0649	0.0023	0	0	0.0002	0.0060	0	rs16954775	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNU6-1191P	39	0	136	27	0.165644171779141	TRUE	NA
ENSG00000116922.14	.	BCM	GRCh38.p13	chr1	37683345	37683345	+	T	T	C	Missense_Mutation	SNP	ENST00000358011.8	exon4	c.A548G	p.K183R	exonic	ENSG00000116922.14	.	nonsynonymous SNV	ENSG00000116922.14:ENST00000358011.8:exon4:c.A548G:p.K183R	1p34.3	C3L-03630	8.238e-06	0	8.639e-05	0	0	0	0	0	rs758937443	2.17	T	T	B	B	N	N	.	.	N	0.151	T	T	T	0.087	0.229	0.531	0.324	.	T	T	T	D	T	2.442	22.200	0.991	D	N	-0.366	1.460	-0.178	1.838	0.989	0.707	0.654	0.725	0.636	.	5.280	4.140	3.502	1.127	0.651	1.000	0.904	0.988	884	.	.	.	.	C1orf109	177	0	312	49	0.135734072022161	TRUE	NA
ENSG00000178965.14	.	BCM	GRCh38.p13	chr1	74572531	74572531	+	C	C	T	Missense_Mutation	SNP	ENST00000326665.10	exon14	c.G3179A	p.R1060Q	exonic	ENSG00000178965.14	.	nonsynonymous SNV	ENSG00000178965.14:ENST00000326665.10:exon14:c.G3179A:p.R1060Q	1p31.1	C3L-03630	8.239e-06	0	0	0	0	0	0	6.057e-05	rs779101589	0.18	T	T	P	B	.	N	L	T	N	0.202	T	T	T	0.030	0.292	0.088	0.036	.	T	T	T	T	T	1.039	12.100	0.888	N	N	-0.837	0.602	-0.976	0.520	0.000	0.549	0.627	0.547	0.564	.	4.060	-0.351	-0.409	-0.612	0.524	0.000	0.000	0.004	713	.	.	.	ID=COSV58605623;OCCURENCE=2(NS),2(skin),1(upper_aerodigestive_tract)	ERICH3	233	0	380	53	0.122401847575058	TRUE	TRUE
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237633630	237633630	+	T	T	G	Missense_Mutation	SNP	ENST00000366574.7	exon43	c.T6608G	p.F2203C	exonic	ENSG00000198626.17	.	nonsynonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon43:c.T6608G:p.F2203C	1q43	C3L-03630	.	.	.	.	.	.	.	.	.	19.19	D	.	D	D	D	D	M	D	D	0.948	D	D	D	0.964	0.810	0.934	1.395	D	D	D	D	D	D	4.339	29.900	0.993	D	D	0.769	8.198	0.721	8.154	1.000	0.554	0.574	0.602	0.564	.	4.900	4.900	7.971	1.138	0.665	1.000	1.000	0.998	911	RIH_domain	.	.	.	RYR2	143	0	221	30	0.119521912350598	TRUE	TRUE
ENSG00000169618.7	.	BCM	GRCh38.p13	chr2	68655496	68655496	+	G	G	A	Missense_Mutation	SNP	ENST00000303786.5	exon3	c.G1102A	p.G368S	exonic	ENSG00000169618.7	.	nonsynonymous SNV	ENSG00000169618.7:ENST00000303786.5:exon3:c.G1102A:p.G368S	2p13.3	C3L-03630	8.255e-06	0	0	0	0	0	0	6.066e-05	rs748147832	0.20	T	T	B	B	N	N	N	T	N	0.150	T	T	T	0.136	0.382	0.738	0.154	T	T	T	T	T	T	0.668	8.155	0.183	N	N	-0.933	0.479	-0.732	0.854	0.806	0.615	0.590	0.659	0.530	.	4.420	3.300	3.478	-0.904	-0.174	0.977	0.000	0.001	867	.	.	.	ID=COSV100375851;OCCURENCE=1(stomach)	PROKR1	346	0	522	95	0.153970826580227	TRUE	NA
ENSG00000144029.12	.	BCM	GRCh38.p13	chr2	95090397	95090397	+	G	G	A	Missense_Mutation	SNP	ENST00000272418.7	exon11	c.C1057T	p.L353F	exonic	ENSG00000144029.12	.	nonsynonymous SNV	ENSG00000144029.12:ENST00000272418.7:exon11:c.C1057T:p.L353F	2q11.1	C3L-03630	.	.	.	.	.	.	.	.	.	9.19	D	T	P	P	D	D	M	.	D	0.645	T	T	T	0.434	0.709	0.738	0.441	T	T	D	D	D	T	3.339	24.200	0.998	D	N	0.327	3.923	0.219	3.277	0.002	0.732	0.725	0.744	0.714	.	5.090	4.080	2.417	1.172	0.614	0.992	0.674	0.345	.	Ribosomal_protein_S5,_C-terminal	.	.	.	MRPS5	162	0	282	54	0.160714285714286	TRUE	TRUE
ENSG00000163254.5	.	BCM	GRCh38.p13	chr2	208128225	208128225	+	C	C	T	Missense_Mutation	SNP	ENST00000282141.4	exon3	c.G503A	p.R168Q	exonic	ENSG00000163254.5	.	nonsynonymous SNV	ENSG00000163254.5:ENST00000282141.4:exon3:c.G503A:p.R168Q	2q33.3	C3L-03630	8.24e-05	0	0	0	0	2.997e-05	0	0.0005	rs539234728	11.19	D	D	P	B	N	D	M	D	D	0.209	D	D	D	0.492	0.890	0.852	0.310	T	D	T	T	D	.	1.841	18.030	0.999	N	N	0.111	2.930	0.004	2.374	0.003	0.487	0.574	0.573	0.564	.	4.850	3.980	0.649	1.026	0.549	0.003	0.998	0.927	843	Beta/gamma_crystallin	.	.	ID=COSV52205791;OCCURENCE=1(large_intestine)	CRYGC	267	0	430	63	0.127789046653144	TRUE	TRUE
ENSG00000144736.14	.	BCM	GRCh38.p13	chr3	72824455	72824455	+	C	C	A	Missense_Mutation	SNP	ENST00000325599.13	exon6	c.G696T	p.K232N	exonic	ENSG00000144736.14	.	nonsynonymous SNV	ENSG00000144736.14:ENST00000325599.13:exon6:c.G696T:p.K232N	3p13	C3L-03630	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	D	L	T	N	0.082	T	T	T	0.085	0.490	0.253	0.068	T	T	T	T	T	T	0.898	10.420	0.985	N	N	-0.589	1.007	-0.514	1.180	0.998	0.732	0.744	0.710	0.613	.	5.610	3.770	-0.163	1.026	0.599	0.000	0.914	0.539	788	.	.	.	ID=COSV57764869;OCCURENCE=1(endometrium)	SHQ1	366	2	581	94	0.139259259259259	TRUE	TRUE
ENSG00000114487.10	.	BCM	GRCh38.p13	chr3	109095052	109095052	+	G	G	A	Missense_Mutation	SNP	ENST00000232603.10	exon7	c.C440T	p.P147L	exonic	ENSG00000114487.10	.	nonsynonymous SNV	ENSG00000114487.10:ENST00000232603.10:exon7:c.C440T:p.P147L	3q13.13	C3L-03630	.	.	.	.	.	.	.	.	.	9.20	T	T	P	P	D	D	L	T	D	0.685	T	T	D	0.295	0.417	0.628	0.673	T	D	T	T	D	D	4.026	27.200	0.997	D	D	0.452	4.686	0.520	5.351	0.993	0.487	0.574	0.574	0.564	.	5.430	5.430	8.294	1.155	0.676	1.000	0.999	0.977	892	.	.	.	ID=COSV99225584;OCCURENCE=1(lung)	MORC1	207	1	402	52	0.114537444933921	TRUE	TRUE
ENSG00000173226.17	.	BCM	GRCh38.p13	chr3	121807399	121807399	+	C	C	T	Missense_Mutation	SNP	ENST00000310864.11	exon7	c.G532A	p.V178I	exonic	ENSG00000173226.17	.	nonsynonymous SNV	ENSG00000173226.17:ENST00000310864.11:exon7:c.G532A:p.V178I	3q13.33	C3L-03630	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.279	T	T	T	0.017	0.271	0.307	0.068	T	T	T	T	T	T	1.571	16.190	0.992	D	N	-0.348	1.499	-0.148	1.915	0.418	0.732	0.744	0.659	0.684	.	5.440	3.620	1.194	0.966	0.530	1.000	0.999	0.978	635	.	.	.	.	IQCB1	176	1	287	34	0.105919003115265	TRUE	NA
ENSG00000161202.20	.	BCM	GRCh38.p13	chr3	184168021	184168021	+	C	C	T	Missense_Mutation	SNP	ENST00000313143.9	exon13	c.C1454T	p.T485I	exonic	ENSG00000161202.20	.	nonsynonymous SNV	ENSG00000161202.20:ENST00000313143.9:exon13:c.C1454T:p.T485I	3q27.1	C3L-03630	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.961	T	T	D	0.507	0.614	0.560	1.776	D	D	D	D	D	D	3.891	26.300	0.999	D	D	0.984	13.431	0.930	15.086	1.000	0.707	0.725	0.723	0.711	.	5.640	5.640	7.905	1.026	0.599	1.000	1.000	0.999	862	DEP_domain	.	.	.	DVL3	421	0	622	91	0.127629733520337	TRUE	TRUE
ENSG00000152795.17	.	BCM	GRCh38.p13	chr4	82426093	82426093	+	C	C	T	Missense_Mutation	SNP	ENST00000621267.4	exon7	c.G1229A	p.G410D	exonic	ENSG00000152795.17	.	nonsynonymous SNV	ENSG00000152795.17:ENST00000621267.4:exon7:c.G1229A:p.G410D	4q21.22	C3L-03630	.	.	.	.	.	.	.	.	.	16.20	D	D	B	B	D	D	M	D	D	0.716	D	D	D	0.650	0.445	0.838	1.568	T	T	D	D	D	D	3.063	23.500	0.997	D	D	0.233	3.450	0.353	4.041	1.000	0.722	0.663	0.699	0.735	.	5.770	4.930	4.545	1.011	0.599	1.000	1.000	0.998	910	.	.	.	.	HNRNPDL	234	0	483	44	0.0834914611005693	TRUE	TRUE
ENSG00000145555.15	.	BCM	GRCh38.p13	chr5	16701414	16701414	+	T	T	C	Missense_Mutation	SNP	ENST00000513610.6	exon25	c.A2981G	p.D994G	exonic	ENSG00000145555.15	.	nonsynonymous SNV	ENSG00000145555.15:ENST00000513610.6:exon25:c.A2981G:p.D994G	5p15.1	C3L-03630	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	.	D	M	D	D	0.792	D	D	D	0.586	0.214	0.880	0.835	T	T	D	D	D	D	4.189	28.600	0.998	D	D	0.415	4.438	0.378	4.209	1.000	0.722	0.574	0.696	0.735	.	4.800	4.800	8.017	1.138	0.665	1.000	0.994	0.457	809	.	.	.	.	MYO10	381	0	546	96	0.149532710280374	TRUE	TRUE
ENSG00000112964.14	.	BCM	GRCh38.p13	chr5	42699919	42699919	+	C	C	T	Missense_Mutation	SNP	ENST00000230882.9	exon6	c.C535T	p.R179C	exonic	ENSG00000112964.14	.	nonsynonymous SNV	ENSG00000112964.14:ENST00000230882.9:exon6:c.C535T:p.R179C	5p12	C3L-03630	0.0041	0.0012	0.0021	0	0.0023	0.0059	0.0077	0.0027	rs121909362	11.20	D	D	P	B	D	A	L	D	N	0.724	D	D	D	0.609	.	0.981	0.061	T	T	T	D	T	T	1.803	17.750	0.995	D	D	-0.034	2.391	0.012	2.401	0.001	0.554	0.588	0.618	0.564	.	5.910	3.190	1.304	-0.241	-0.194	0.592	0.983	0.982	495	Fibronectin_type_III;Long_hematopoietin_receptor,_single_chain,_conserved_site	.	.	ID=COSV99039086;OCCURENCE=2(lung)	GHR	387	0	669	73	0.0983827493261455	TRUE	NA
ENSG00000113296.14	.	BCM	GRCh38.p13	chr5	80071145	80071145	+	G	G	A	Missense_Mutation	SNP	ENST00000350881.6	exon13	c.G1685A	p.R562K	exonic	ENSG00000113296.14	.	nonsynonymous SNV	ENSG00000113296.14:ENST00000350881.6:exon13:c.G1685A:p.R562K	5q14.1	C3L-03630	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	N	N	D	N	0.205	D	D	D	0.317	0.395	0.530	0.254	T	T	T	T	T	T	-0.116	0.768	0.793	N	N	-1.270	0.182	-1.235	0.255	1.000	0.706	0.593	0.710	0.564	.	5.230	-2.850	-0.051	-0.068	-0.116	0.010	0.969	0.924	627	.	.	.	.	THBS4	71	0	136	9	0.0620689655172414	TRUE	TRUE
ENSG00000145808.10	.	BCM	GRCh38.p13	chr5	129509182	129509182	+	A	A	G	Missense_Mutation	SNP	ENST00000274487.9	exon3	c.A853G	p.M285V	exonic	ENSG00000145808.10	.	nonsynonymous SNV	ENSG00000145808.10:ENST00000274487.9:exon3:c.A853G:p.M285V	5q23.3	C3L-03630	.	.	.	.	.	.	.	.	rs1045960086	0.16	.	.	B	B	N	N	N	.	.	.	T	T	T	0.089	0.242	0.400	0.172	T	T	T	T	T	T	-0.437	0.161	0.608	N	N	-1.215	0.217	-1.220	0.267	0.068	0.693	0.574	0.659	0.564	.	4.420	-4.990	-0.625	1.312	0.756	0.004	0.995	0.960	725	.	.	.	.	ADAMTS19	222	0	332	47	0.12401055408971	TRUE	NA
ENSG00000204498.11	.	BCM	GRCh38.p13	chr6	31558438	31558438	+	G	G	T	Nonsense_Mutation	SNP	ENST00000376148.9	exon4	c.G973T	p.E325X	exonic	ENSG00000204498.11	.	stopgain	ENSG00000204498.11:ENST00000376148.9:exon4:c.G973T:p.E325X	6p21.33	C3L-03630	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.895	.	.	.	.	.	.	.	.	.	D	D	.	.	8.040	40	0.996	D	N	0.981	13.343	0.834	11.210	1.000	0.732	0.672	0.744	0.662	.	6.080	5.040	3.640	1.176	0.676	1.000	0.971	0.701	934	.	.	.	.	NFKBIL1	134	0	285	130	0.313253012048193	TRUE	TRUE
ENSG00000237649.8	.	BCM	GRCh38.p13	chr6	33406199	33406199	+	G	G	A	Missense_Mutation	SNP	ENST00000428849.7	exon8	c.G1540A	p.D514N	exonic	ENSG00000237649.8	.	nonsynonymous SNV	ENSG00000237649.8:ENST00000428849.7:exon8:c.G1540A:p.D514N	6p21.32	C3L-03630	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	N	T	N	0.125	T	T	T	0.144	0.512	0.776	0.377	T	T	T	T	T	.	0.777	9.167	0.987	D	N	-0.590	1.007	-0.462	1.265	1.000	0.732	0.702	0.702	0.728	.	4.250	3.350	0.457	0.213	-0.113	0.526	0.139	0.001	365	Kinesin_motor_domain	.	.	.	KIFC1	86	0	150	17	0.101796407185629	TRUE	TRUE
ENSG00000188112.9	.	BCM	GRCh38.p13	chr6	42105199	42105199	+	C	C	A	Missense_Mutation	SNP	ENST00000341865.9	exon4	c.G2713T	p.D905Y	exonic	ENSG00000188112.9	.	nonsynonymous SNV	ENSG00000188112.9:ENST00000341865.9:exon4:c.G2713T:p.D905Y	6p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	5.16	D	D	.	.	.	N	L	T	D	0.203	T	T	D	0.060	0.148	0.192	.	.	T	T	T	D	T	2.671	22.800	0.981	N	N	-0.552	1.077	-0.617	1.021	1.000	0.598	0.596	0.269	0.563	.	4.680	2.800	0.185	0.113	0.529	0.005	0.042	0.113	921	.	.	.	.	C6orf132	243	1	738	193	0.207303974221267	TRUE	TRUE
ENSG00000188112.9	.	BCM	GRCh38.p13	chr6	42105205	42105205	+	C	C	T	Missense_Mutation	SNP	ENST00000341865.9	exon4	c.G2707A	p.E903K	exonic	ENSG00000188112.9	.	nonsynonymous SNV	ENSG00000188112.9:ENST00000341865.9:exon4:c.G2707A:p.E903K	6p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	2.16	T	T	.	.	.	N	N	T	N	0.071	T	T	D	0.014	0.156	0.048	.	.	T	T	T	D	T	1.116	12.920	0.990	N	N	-0.581	1.023	-0.664	0.952	1.000	0.598	0.596	0.269	0.563	.	4.680	2.660	0.313	1.002	0.529	0.000	0.016	0.085	922	.	.	.	.	C6orf132	259	0	772	213	0.216243654822335	TRUE	TRUE
ENSG00000188112.9	.	BCM	GRCh38.p13	chr6	42105517	42105517	+	C	C	T	Missense_Mutation	SNP	ENST00000341865.9	exon4	c.G2395A	p.E799K	exonic	ENSG00000188112.9	.	nonsynonymous SNV	ENSG00000188112.9:ENST00000341865.9:exon4:c.G2395A:p.E799K	6p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	0.16	T	T	.	.	.	N	N	T	N	0.045	T	T	T	0.032	0.214	0.030	.	.	T	T	T	T	T	1.153	13.250	0.963	N	N	-0.549	1.082	-0.636	0.993	1.000	0.632	0.563	0.780	0.563	.	4.240	3.370	1.088	1.010	0.580	0.002	0.004	0.019	922	.	.	.	.	C6orf132	147	0	371	145	0.281007751937984	TRUE	TRUE
ENSG00000188112.9	.	BCM	GRCh38.p13	chr6	42105909	42105909	+	C	C	G	Missense_Mutation	SNP	ENST00000341865.9	exon4	c.G2003C	p.G668A	exonic	ENSG00000188112.9	.	nonsynonymous SNV	ENSG00000188112.9:ENST00000341865.9:exon4:c.G2003C:p.G668A	6p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	2.16	D	T	.	.	.	N	L	T	D	0.103	T	T	T	0.057	0.155	0.014	.	.	T	T	T	T	T	0.904	10.470	0.974	N	N	-0.859	0.573	-0.962	0.537	0.999	0.696	0.563	0.723	0.605	.	3.340	1.490	-0.718	0.008	0.490	0.000	0.003	0.002	923	.	.	.	.	C6orf132	689	0	1743	594	0.254172015404365	TRUE	TRUE
ENSG00000188112.9	.	BCM	GRCh38.p13	chr6	42106093	42106093	+	C	C	T	Missense_Mutation	SNP	ENST00000341865.9	exon4	c.G1819A	p.D607N	exonic	ENSG00000188112.9	.	nonsynonymous SNV	ENSG00000188112.9:ENST00000341865.9:exon4:c.G1819A:p.D607N	6p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	0.16	T	T	.	.	.	N	N	T	N	0.042	T	T	T	0.057	0.121	0.040	.	.	T	T	T	T	T	-0.605	0.071	0.107	N	N	-1.122	0.287	-1.180	0.300	0.959	0.696	0.563	0.723	0.605	.	4.430	0.292	-0.957	-0.643	-0.722	0.000	0.060	0.237	923	.	.	.	.	C6orf132	442	0	1267	202	0.137508509189925	TRUE	TRUE
ENSG00000188112.9	.	BCM	GRCh38.p13	chr6	42106096	42106096	+	C	C	T	Missense_Mutation	SNP	ENST00000341865.9	exon4	c.G1816A	p.D606N	exonic	ENSG00000188112.9	.	nonsynonymous SNV	ENSG00000188112.9:ENST00000341865.9:exon4:c.G1816A:p.D606N	6p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	1.16	D	T	.	.	.	N	L	T	N	0.058	T	T	T	0.047	0.118	0.030	.	.	T	T	T	T	T	0.757	8.979	0.993	N	N	-0.635	0.925	-0.716	0.876	0.995	0.696	0.563	0.723	0.605	.	4.850	3.070	0.375	1.010	0.580	0.000	0.046	0.240	923	.	.	.	.	C6orf132	445	1	1283	197	0.133108108108108	TRUE	TRUE
ENSG00000135298.14	.	BCM	GRCh38.p13	chr6	69324920	69324920	+	T	T	A	Missense_Mutation	SNP	ENST00000370598.6	exon21	c.T2863A	p.S955T	exonic	ENSG00000135298.14	.	nonsynonymous SNV	ENSG00000135298.14:ENST00000370598.6:exon21:c.T2863A:p.S955T	6q13	C3L-03630	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	.	T	D	0.657	T	T	T	0.351	0.831	0.365	2.082	D	T	D	T	D	D	3.999	27.000	0.996	D	D	0.677	6.803	0.726	8.274	1.000	0.554	0.574	0.618	0.564	.	6.070	6.070	7.991	1.138	0.665	1.000	1.000	0.989	680	GPCR,_family_2-like	.	.	.	ADGRB3	151	0	279	19	0.063758389261745	TRUE	TRUE
ENSG00000135541.21	.	BCM	GRCh38.p13	chr6	135466081	135466081	+	G	G	A	Missense_Mutation	SNP	ENST00000265602.11	exon7	c.C482T	p.P161L	exonic	ENSG00000135541.21	.	nonsynonymous SNV	ENSG00000135541.21:ENST00000265602.11:exon7:c.C482T:p.P161L	6q23.3	C3L-03630	.	.	.	.	.	.	.	.	.	2.20	D	T	B	B	N	N	N	T	D	0.118	T	T	T	0.098	0.168	0.444	0.042	T	T	T	T	T	T	0.812	9.515	0.650	N	N	-0.677	0.852	-0.691	0.913	1.000	0.693	0.634	0.659	0.636	.	5.860	3.150	2.197	1.175	0.676	0.026	0.026	0.006	692	.	.	.	.	AHI1	271	0	362	80	0.180995475113122	TRUE	TRUE
ENSG00000147419.19	.	BCM	GRCh38.p13	chr8	27736241	27736241	+	C	C	T	Missense_Mutation	SNP	ENST00000356537.9	exon9	c.G602A	p.G201D	exonic	ENSG00000147419.19	.	nonsynonymous SNV	ENSG00000147419.19:ENST00000356537.9:exon9:c.G602A:p.G201D	8p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	9.18	D	T	D	P	D	D	.	.	D	0.325	T	T	T	0.141	0.204	0.435	0.738	T	T	D	D	D	T	2.935	23.300	0.998	D	N	0.464	4.771	0.470	4.894	0.972	0.732	0.725	0.744	0.728	.	5.120	5.120	2.151	1.015	0.599	0.998	0.968	0.941	743	.	.	.	.	CCDC25	102	0	215	21	0.0889830508474576	TRUE	TRUE
ENSG00000091656.19	.	BCM	GRCh38.p13	chr8	76863765	76863765	+	A	A	C	Missense_Mutation	SNP	ENST00000651372.2	exon11	c.A10051C	p.K3351Q	exonic	ENSG00000091656.19	.	nonsynonymous SNV	ENSG00000091656.19:ENST00000651372.2:exon11:c.A10051C:p.K3351Q	8q21.13	C3L-03630	.	.	.	.	.	.	.	.	.	3.16	T	T	.	.	U	N	.	T	N	0.320	T	T	T	0.063	0.178	0.139	0.189	T	.	T	T	D	T	1.953	18.900	0.949	D	D	-0.322	1.560	-0.153	1.902	0.129	0.638	0.574	0.618	0.668	.	4.680	3.510	3.154	1.312	0.756	0.999	0.971	0.969	796	.	.	.	.	ZFHX4	365	0	546	71	0.115072933549433	TRUE	TRUE
ENSG00000185189.18	.	BCM	GRCh38.p13	chr8	143840182	143840182	+	C	C	G	Missense_Mutation	SNP	ENST00000442628.7	exon2	c.G177C	p.M59I	exonic	ENSG00000185189.18	.	nonsynonymous SNV	ENSG00000185189.18:ENST00000442628.7:exon2:c.G177C:p.M59I	8q24.3	C3L-03630	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	.	D	M	D	D	0.464	D	D	D	0.663	0.544	0.918	0.737	T	T	D	D	D	D	3.939	26.600	0.997	D	D	0.579	5.714	0.505	5.203	1.000	0.767	0.587	0.851	0.658	.	3.510	3.510	7.303	1.008	0.529	1.000	1.000	0.993	940	Protein_kinase_domain	.	.	.	NRBP2	270	1	414	58	0.122881355932203	TRUE	TRUE
ENSG00000178209.15	.	BCM	GRCh38.p13	chr8	143916635	143916635	+	C	C	T	Missense_Mutation	SNP	ENST00000322810.8	exon32	c.G13597A	p.G4533S	exonic	ENSG00000178209.15	.	nonsynonymous SNV	ENSG00000178209.15:ENST00000322810.8:exon32:c.G13597A:p.G4533S	8q24.3	C3L-03630	.	.	.	.	.	.	.	.	rs759155242	16.20	D	D	D	D	U	D	H	D	N	0.834	D	D	D	0.776	0.901	0.801	.	T	T	D	D	D	D	3.520	24.800	0.951	D	D	0.892	10.854	0.790	9.826	1.000	0.707	0.702	0.723	0.714	.	5.190	5.190	6.037	1.026	0.589	1.000	0.039	0.257	970	.	.	.	.	PLEC	356	0	492	91	0.156089193825043	TRUE	NA
ENSG00000165271.17	.	BCM	GRCh38.p13	chr9	33469636	33469636	+	T	T	G	Missense_Mutation	SNP	ENST00000379471.3	exon5	c.A590C	p.Q197P	exonic	ENSG00000165271.17	.	nonsynonymous SNV	ENSG00000165271.17:ENST00000379471.3:exon5:c.A590C:p.Q197P	9p13.3	C3L-03630	.	.	.	.	.	.	.	.	.	13.20	T	D	D	P	D	D	M	T	D	0.897	T	T	D	0.428	0.633	0.697	0.822	T	T	D	D	D	D	3.905	26.400	0.993	D	D	0.614	6.068	0.647	6.870	1.000	0.719	0.723	0.725	0.714	.	5.680	5.680	7.266	1.138	0.665	1.000	1.000	0.993	576	Nrap_protein_domain_1	.	.	.	NOL6	183	0	337	41	0.108465608465608	TRUE	TRUE
ENSG00000010438.16	.	BCM	GRCh38.p13	chr9	33796663	33796663	+	G	G	A	Missense_Mutation	SNP	ENST00000361005.9	exon2	c.G232A	p.D78N	exonic	ENSG00000010438.16	.	nonsynonymous SNV	ENSG00000010438.16:ENST00000361005.9:exon2:c.G232A:p.D78N	9p13.3	C3L-03630	.	.	.	.	.	.	.	.	.	12.20	D	T	P	P	D	D	N	D	D	0.489	D	D	D	0.359	0.458	0.879	0.301	T	T	T	T	D	D	3.173	23.800	0.996	D	D	-0.156	2.003	-0.132	1.957	1.000	0.537	0.541	0.492	0.530	.	3.210	3.210	5.564	0.691	0.308	1.000	0.452	0.329	357	.	.	.	.	PRSS3	283	0	463	53	0.102713178294574	NA	TRUE
ENSG00000048828.17	.	BCM	GRCh38.p13	chr9	93561193	93561193	+	G	G	A	Missense_Mutation	SNP	ENST00000277165.11	exon16	c.G2891A	p.R964H	exonic	ENSG00000048828.17	.	nonsynonymous SNV	ENSG00000048828.17:ENST00000277165.11:exon16:c.G2891A:p.R964H	9q22.31	C3L-03630	8.406e-06	0	8.787e-05	0	0	0	0	0	rs764432382	9.20	D	D	B	B	D	D	L	T	D	0.699	T	T	T	0.223	0.246	0.360	1.594	T	T	T	T	D	D	3.724	25.500	0.999	D	D	0.401	4.347	0.514	5.288	1.000	0.732	0.725	0.744	0.714	.	6.160	5.270	9.735	1.176	0.676	1.000	0.971	0.990	952	.	.	.	.	FAM120A	342	0	574	107	0.15712187958884	TRUE	NA
ENSG00000136861.18	.	BCM	GRCh38.p13	chr9	120527890	120527890	+	T	T	G	Missense_Mutation	SNP	ENST00000349780.9	exon10	c.A915C	p.E305D	exonic	ENSG00000136861.18	.	nonsynonymous SNV	ENSG00000136861.18:ENST00000349780.9:exon10:c.A915C:p.E305D	9q33.2	C3L-03630	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	D	0.589	T	T	T	0.162	0.089	0.528	0.118	T	T	T	T	D	D	3.349	24.300	0.996	D	N	0.457	4.718	0.440	4.652	1.000	0.732	0.725	0.744	0.728	.	6.030	4.890	2.912	1.138	0.663	1.000	1.000	0.990	846	.	.	.	ID=COSV62572192;OCCURENCE=1(endometrium)	CDK5RAP2	257	0	525	61	0.104095563139932	TRUE	TRUE
ENSG00000160323.18	.	BCM	GRCh38.p13	chr9	133437862	133437876	+	GGGACCCTGAGCCTG	GGGACCCTGAGCCTG	-	In_Frame_Del	DEL	ENST00000371929.7	exon13	c.1549_1563del	p.G517_L521del	exonic	ENSG00000160323.18	.	nonframeshift deletion	ENSG00000160323.18:ENST00000371929.7:exon13:c.1549_1563del:p.G517_L521del	9q34.2	C3L-03630	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAMTS13	831	0	1111	148	0.117553613979349	TRUE	NA
ENSG00000203791.15	.	BCM	GRCh38.p13	chr10	124762369	124762369	+	G	G	C	Nonsense_Mutation	SNP	ENST00000368836.7	exon6	c.C806G	p.S269X	exonic	ENSG00000203791.15	.	stopgain	ENSG00000203791.15:ENST00000368836.7:exon6:c.C806G:p.S269X	10q26.13	C3L-03630	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	.	.	.	.	0.009	.	.	.	.	.	.	.	.	.	D	D	.	.	4.888	33	0.635	N	N	-0.243	1.759	-0.698	0.902	0.803	0.707	0.725	0.725	0.714	.	1.220	-1.310	0.806	0.576	-0.203	0.056	0.025	0.002	524	.	.	.	.	EEF1AKMT2	100	0	178	25	0.123152709359606	NA	TRUE
ENSG00000130640.13	.	BCM	GRCh38.p13	chr10	133285544	133285544	+	C	C	T	Missense_Mutation	SNP	ENST00000368563.6	exon12	c.G1807A	p.A603T	exonic	ENSG00000130640.13	.	nonsynonymous SNV	ENSG00000130640.13:ENST00000368563.6:exon12:c.G1807A:p.A603T	10q26.3	C3L-03630	9.375e-06	0	0	0	0	1.641e-05	0	0	rs759006952	5.20	T	T	B	B	D	D	L	T	N	0.721	T	T	T	0.250	0.316	0.376	0.347	T	T	T	T	T	D	2.177	20.700	0.998	D	D	-0.097	2.183	0.038	2.495	1.000	0.719	0.723	0.723	0.714	.	5.640	5.640	7.540	0.990	0.599	1.000	0.015	0.163	993	.	.	.	.	TUBGCP2	62	0	109	16	0.128	TRUE	NA
ENSG00000165917.10	.	BCM	GRCh38.p13	chr11	47448105	47448105	+	C	C	T	Missense_Mutation	SNP	ENST00000298854.7	exon2	c.G238A	p.D80N	exonic	ENSG00000165917.10	.	nonsynonymous SNV	ENSG00000165917.10:ENST00000298854.7:exon2:c.G238A:p.D80N	11p11.2	C3L-03630	2.49e-05	0.0002	0	0	0	1.512e-05	0	0	rs781724566	2.20	T	T	B	B	N	D	L	T	N	0.196	T	T	T	0.033	0.585	0.633	0.156	T	T	T	T	T	T	1.638	16.620	0.941	D	N	-0.711	0.794	-0.561	1.106	1.000	0.570	0.551	0.658	0.492	.	4.820	0.578	2.413	0.130	-0.176	0.975	0.971	0.789	19	Rapsyn,_myristoylation/linker_region,_N-terminal	.	.	ID=COSV54084160;OCCURENCE=1(liver),1(large_intestine)	RAPSN	297	0	559	71	0.112698412698413	TRUE	TRUE
ENSG00000170322.14	.	BCM	GRCh38.p13	chr11	129874170	129874170	+	G	G	A	Missense_Mutation	SNP	ENST00000446488.7	exon20	c.C2222T	p.S741L	exonic	ENSG00000170322.14	.	nonsynonymous SNV	ENSG00000170322.14:ENST00000446488.7:exon20:c.C2222T:p.S741L	11q24.3	C3L-03630	5.422e-05	0.0002	0	0	0	6.248e-05	0	0	rs141128592	5.19	D	D	B	B	N	N	L	.	N	0.395	T	T	T	0.054	.	0.068	0.263	T	T	T	T	T	D	2.881	23.200	0.997	D	D	-0.208	1.853	-0.086	2.088	1.000	0.707	0.725	0.725	0.714	.	5.560	5.560	5.230	1.176	0.676	0.943	0.506	0.880	824	.	.	.	ID=COSV58757015;OCCURENCE=1(endometrium)	NFRKB	17	0	24	3	0.111111111111111	TRUE	TRUE
ENSG00000120645.12	.	BCM	GRCh38.p13	chr12	174675	174675	+	C	C	T	Missense_Mutation	SNP	ENST00000538872.6	exon14	c.C3191T	p.P1064L	exonic	ENSG00000120645.12	.	nonsynonymous SNV	ENSG00000120645.12:ENST00000538872.6:exon14:c.C3191T:p.P1064L	12p13.33	C3L-03630	1.054e-05	0	0	0	0	1.88e-05	0	0	rs747026524	0.20	T	T	B	B	U	N	L	T	N	0.077	T	T	T	0.031	0.250	0.123	0.394	T	T	T	T	T	T	-0.597	0.074	0.892	N	N	-1.253	0.192	-1.334	0.188	1.000	0.646	0.547	0.645	0.563	.	3.660	-4.420	-0.363	0.060	-0.315	0.000	0.017	0.068	940	.	.	.	ID=COSV58290439;OCCURENCE=1(stomach)	IQSEC3	109	0	160	37	0.187817258883249	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-03630	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	295	0	460	80	0.148148148148148	TRUE	TRUE
ENSG00000198598.6	.	BCM	GRCh38.p13	chr12	131849987	131849987	+	G	G	A	Missense_Mutation	SNP	ENST00000360564.5	exon9	c.G1390A	p.G464S	exonic	ENSG00000198598.6	.	nonsynonymous SNV	ENSG00000198598.6:ENST00000360564.5:exon9:c.G1390A:p.G464S	12q24.33	C3L-03630	2.497e-05	0	0	0	0	3.041e-05	0.0011	0	rs779153151	15.20	D	D	D	D	D	D	M	T	D	0.779	T	T	D	0.539	0.437	0.712	0.764	T	T	D	D	D	D	4.250	29.100	0.999	D	D	0.809	8.967	0.758	8.987	1.000	0.706	0.588	0.723	0.613	.	4.920	4.920	7.931	1.083	0.618	1.000	0.998	0.991	982	Hemopexin-like_domain	.	.	ID=COSV62179778;OCCURENCE=1(stomach)	MMP17	347	0	611	47	0.0714285714285714	TRUE	TRUE
ENSG00000099814.16	.	BCM	GRCh38.p13	chr14	104886598	104886598	+	A	A	G	Missense_Mutation	SNP	ENST00000414716.8	exon12	c.A2359G	p.R787G	exonic	ENSG00000099814.16	.	nonsynonymous SNV	ENSG00000099814.16:ENST00000414716.8:exon12:c.A2359G:p.R787G	14q32.33	C3L-03630	.	.	.	.	.	.	.	.	.	5.20	D	T	P	B	N	N	M	T	D	0.378	T	T	D	0.049	0.300	0.196	0.230	T	T	T	T	D	T	1.118	12.940	0.916	N	N	-0.975	0.432	-1.135	0.341	0.931	0.646	0.547	0.645	0.636	.	4.620	-5.450	-0.019	-0.168	0.756	0.000	0.001	0.030	976	.	.	.	.	CEP170B	31	0	58	8	0.121212121212121	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674230	7674230	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.G733A	p.G245S	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.G733A:p.G245S	17p13.1	C3L-03630	8.239e-06	0	0	0	0	1.498e-05	0	0	rs28934575	19.20	D	D	D	D	D	D	M	D	D	0.921	D	D	D	0.947	.	0.994	0.387	T	D	D	D	D	D	4.069	27.500	0.999	D	D	0.816	9.103	0.750	8.806	1.000	0.722	0.702	0.725	0.735	.	4.620	4.620	7.905	1.021	0.596	1.000	0.893	0.975	433	p53,_DNA-binding_domain	.	.	ID=COSV52661877;OCCURENCE=4(salivary_gland),48(breast),1(penis),4(liver),34(oesophagus),1(adrenal_gland),2(cervix),215(large_intestine),43(central_nervous_system),3(biliary_tract),27(ovary),6(vulva),1(bone),3(NS),55(stomach),33(haematopoietic_and_lymphoid_tissue),2(kidney),4(soft_tissue),14(urinary_tract),18(pancreas),12(skin),16(prostate),17(lung),6(thyroid),29(upper_aerodigestive_tract),7(small_intestine),13(endometrium)	TP53	403	0	503	95	0.158862876254181	TRUE	TRUE
ENSG00000121068.14	.	BCM	GRCh38.p13	chr17	61404709	61404709	+	C	C	T	Missense_Mutation	SNP	ENST00000240328.4	exon5	c.C991T	p.R331W	exonic	ENSG00000121068.14	.	nonsynonymous SNV	ENSG00000121068.14:ENST00000240328.4:exon5:c.C991T:p.R331W	17q23.2	C3L-03630	0.0002	0	0.0026	0	0	0	0	0	rs770492149	15.20	D	D	D	D	N	D	L	D	D	0.590	D	D	D	0.544	0.328	0.850	.	T	D	T	D	T	D	3.497	24.700	0.998	D	D	0.047	2.681	0.001	2.362	1.000	0.598	0.596	0.608	0.639	.	4.750	2.640	0.757	0.134	-0.180	0.225	0.459	0.701	237	Transcription_factor,_T-box,_region_of_unknown_function	.	.	.	TBX2	133	0	213	36	0.144578313253012	TRUE	NA
ENSG00000141338.14	.	BCM	GRCh38.p13	chr17	68919318	68919318	+	G	G	A	Nonsense_Mutation	SNP	ENST00000586539.6	exon14	c.C1771T	p.Q591X	exonic	ENSG00000141338.14	.	stopgain	ENSG00000141338.14:ENST00000586539.6:exon14:c.C1771T:p.Q591X	17q24.2	C3L-03630	1.651e-05	0	8.639e-05	0	0	0	0	6.095e-05	rs775795770	3.6	.	.	.	.	N	A	.	.	.	0.092	.	.	.	.	.	.	.	.	.	D	D	.	.	6.530	36	0.997	N	N	0.116	2.950	-0.199	1.787	0.000	0.554	0.574	0.547	0.568	.	4.540	2.380	0.374	0.167	0.618	0.000	0.570	0.973	933	ABC_transporter-like;AAA+_ATPase_domain	.	.	.	ABCA8	109	0	179	28	0.135265700483092	TRUE	NA
ENSG00000101542.10	.	BCM	GRCh38.p13	chr18	61507379	61507379	+	A	A	G	Missense_Mutation	SNP	ENST00000262717.9	exon6	c.A836G	p.Y279C	exonic	ENSG00000101542.10	.	nonsynonymous SNV	ENSG00000101542.10:ENST00000262717.9:exon6:c.A836G:p.Y279C	18q21.33	C3L-03630	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.927	D	D	D	0.762	0.677	0.861	1.182	D	T	D	D	D	D	4.237	29.000	0.998	D	D	1.069	16.276	0.948	15.992	1.000	0.487	0.574	0.574	0.542	.	5.450	5.450	9.325	1.312	0.756	1.000	1.000	0.989	787	Cadherin-like	.	.	.	CDH20	209	0	244	56	0.186666666666667	TRUE	TRUE
ENSG00000101470.10	.	BCM	GRCh38.p13	chr20	45824065	45824065	+	T	T	C	Missense_Mutation	SNP	ENST00000372555.8	exon5	c.A377G	p.H126R	exonic	ENSG00000101470.10	.	nonsynonymous SNV	ENSG00000101470.10:ENST00000372555.8:exon5:c.A377G:p.H126R	20q13.12	C3L-03630	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	N	T	N	0.336	T	T	D	0.109	0.279	0.273	1.004	T	T	T	T	T	D	2.609	22.700	0.971	D	N	-0.468	1.241	-0.277	1.612	1.000	0.726	0.541	0.594	0.568	.	4.120	4.120	1.195	1.138	0.609	1.000	0.996	0.972	819	EF-hand_domain	.	.	.	TNNC2	281	0	469	75	0.137867647058824	TRUE	TRUE
ENSG00000182541.18	.	BCM	GRCh38.p13	chr22	31266022	31266022	+	C	C	T	Missense_Mutation	SNP	ENST00000331728.9	exon8	c.C931T	p.R311C	exonic	ENSG00000182541.18	.	nonsynonymous SNV	ENSG00000182541.18:ENST00000331728.9:exon8:c.C931T:p.R311C	22q12.2	C3L-03630	.	.	.	.	.	.	.	.	rs769771373	19.20	D	D	D	D	D	D	M	D	D	0.857	D	D	D	0.781	0.269	0.967	0.807	T	D	D	D	D	D	4.409	31	0.999	D	D	0.802	8.822	0.770	9.292	1.000	0.745	0.702	0.732	0.714	.	5.150	5.150	7.568	1.026	0.549	1.000	0.999	0.999	572	.	.	.	.	LIMK2	243	0	438	39	0.0817610062893082	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21974677	21974677	+	C	C	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000147889.17	ENST00000304494.9:exon1:c.150+1G>C	.	.	9p21.3	C3L-03630	.	.	.	.	.	.	.	.	.	5.5	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.582	32	0.991	D	D	0.477	4.863	0.450	4.734	1.000	0.658	0.707	0.607	0.555	.	4.890	4.890	3.530	1.026	0.599	1.000	0.753	0.211	893	.	.	.	ID=COSV58691878;OCCURENCE=2(liver),1(haematopoietic_and_lymphoid_tissue)	CDKN2A	310	0	386	72	0.157205240174672	TRUE	TRUE
ENSG00000163029.16	.	BCM	GRCh38.p13	chr2	17716902	17716902	+	A	A	T	Silent	SNP	ENST00000448223.7	exon14	c.T1185A	p.T395T	exonic	ENSG00000163029.16	.	synonymous SNV	ENSG00000163029.16:ENST00000448223.7:exon14:c.T1185A:p.T395T	2p24.2	C3L-03630	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMC6	80	0	160	28	0.148936170212766	TRUE	TRUE
ENSG00000115946.8	.	BCM	GRCh38.p13	chr2	68174766	68174766	+	T	T	C	Silent	SNP	ENST00000263657.7	exon7	c.T723C	p.I241I	exonic	ENSG00000115946.8	.	synonymous SNV	ENSG00000115946.8:ENST00000263657.7:exon7:c.T723C:p.I241I	2p14	C3L-03630	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PNO1	108	0	187	24	0.113744075829384	TRUE	NA
ENSG00000149177.13	.	BCM	GRCh38.p13	chr11	48127850	48127850	+	C	C	A	Silent	SNP	ENST00000418331.7	exon7	c.C1164A	p.V388V	exonic	ENSG00000149177.13	.	synonymous SNV	ENSG00000149177.13:ENST00000418331.7:exon7:c.C1164A:p.V388V	11p11.2	C3L-03630	8.238e-06	0	0	0	0	0	0	6.056e-05	rs762925560	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTPRJ	144	0	270	34	0.111842105263158	TRUE	NA
ENSG00000149485.19	.	BCM	GRCh38.p13	chr11	61802914	61802914	+	C	C	T	Silent	SNP	ENST00000350997.12	exon11	c.G1341A	p.T447T	exonic	ENSG00000149485.19	.	synonymous SNV	ENSG00000149485.19:ENST00000350997.12:exon11:c.G1341A:p.T447T	11q12.2	C3L-03630	2.487e-05	0.0002	0	0	0	1.501e-05	0	0	rs115713429	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63521220;OCCURENCE=1(urinary_tract)	FADS1	195	1	286	45	0.13595166163142	TRUE	TRUE
ENSG00000168286.3	.	BCM	GRCh38.p13	chr16	67843325	67843325	+	C	C	T	Silent	SNP	ENST00000303596.3	exon1	c.C771T	p.L257L	exonic	ENSG00000168286.3	.	synonymous SNV	ENSG00000168286.3:ENST00000303596.3:exon1:c.C771T:p.L257L	16q22.1	C3L-03630	1.652e-05	0	0	0	0	3.01e-05	0	0	rs774473286	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	THAP11	176	0	282	43	0.132307692307692	TRUE	NA
ENSG00000183048.12	.	BCM	GRCh38.p13	chr17	81715709	81715709	+	C	C	T	Silent	SNP	ENST00000350690.10	exon4	c.C345T	p.F115F	exonic	ENSG00000183048.12;ENSG00000262660.1	.	synonymous SNV	ENSG00000183048.12:ENST00000350690.10:exon4:c.C345T:p.F115F,ENSG00000262660.1:ENST00000571730.1:exon8:c.C810T:p.F270F	17q25.3	C3L-03630	9.137e-05	0.0011	0	0	0	0	0	0	rs199916012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC25A10	436	0	718	86	0.106965174129353	TRUE	NA
ENSG00000179242.16	.	BCM	GRCh38.p13	chr20	61928323	61928323	+	G	G	A	Silent	SNP	ENST00000614565.5	exon12	c.G1905A	p.A635A	exonic	ENSG00000179242.16	.	synonymous SNV	ENSG00000179242.16:ENST00000614565.5:exon12:c.G1905A:p.A635A	20q13.33	C3L-03630	.	.	.	.	.	.	.	.	rs936184978	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDH4	574	0	925	152	0.141132776230269	TRUE	NA
ENSG00000211655.3	.	BCM	GRCh38.p13	chr22	22432313	22432313	+	C	C	A	Silent	SNP	ENST00000390301.3	exon2	c.C201A	p.L67L	exonic	ENSG00000211655.3	.	synonymous SNV	ENSG00000211655.3:ENST00000390301.3:exon2:c.C201A:p.L67L	22q11.22	C3L-03630	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGLV1-36	417	0	607	109	0.152234636871508	TRUE	TRUE
ENSG00000131831.18	.	BCM	GRCh38.p13	chrX	17801675	17801675	+	G	G	A	Silent	SNP	ENST00000545871.1	exon3	c.C336T	p.Y112Y	exonic	ENSG00000131831.18	.	synonymous SNV	ENSG00000131831.18:ENST00000545871.1:exon3:c.C336T:p.Y112Y	Xp22.13	C3L-03630	5.72e-05	0.0001	0	0	0	6.26e-05	0	9.897e-05	rs760262315	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58964040;OCCURENCE=1(large_intestine)	RAI2	131	2	189	81	0.3	NA	TRUE
ENSG00000211997.1	.	BCM	GRCh38.p13	chr11	79402080	79402080	+	A	A	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000211997.1	.	.	.	11q14.1	C3L-03630	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR708	54	0	124	21	0.144827586206897	TRUE	NA
ENSG00000111452.13	.	BCM	GRCh38.p13	chr12	131002807	131002807	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000111452.13	.	.	.	12q24.33	C3L-03630	0.0003	0.0005	9.122e-05	0.0029	0	3.488e-05	0	0	rs144732392	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55456596;OCCURENCE=1(prostate),1(lung),1(upper_aerodigestive_tract)	ADGRD1	37	0	58	10	0.147058823529412	TRUE	NA
ENSG00000188112.9	.	BCM	GRCh38.p13	chr6	42105150	42105152	+	CCC	CCC	TCT	Unknown	MNP	ENST00000341865.9	exon4	c.2760_2762delinsAGA	p.G921E	exonic	ENSG00000188112.9	.	nonframeshift substitution	ENSG00000188112.9:ENST00000341865.9:exon4:c.2760_2762delinsAGA:p.G921E	6p21.1	C3L-03630	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C6orf132	153	134	461	83	0.152573529411765	TRUE	NA
ENSG00000160323.18	.	BCM	GRCh38.p13	chr9	133437877	133437878	+	TG	TG	CA	Unknown	MNP	ENST00000371929.7	exon13	c.1564_1565delinsCA	p.C522H	exonic	ENSG00000160323.18	.	nonframeshift substitution	ENSG00000160323.18:ENST00000371929.7:exon13:c.1564_1565delinsCA:p.C522H	9q34.2	C3L-03630	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAMTS13	689	0	1037	155	0.13003355704698	NA	TRUE
ENSG00000179002.5	.	BCM	GRCh38.p13	chr1	18849391	18849391	+	G	G	A	Nonsense_Mutation	SNP	ENST00000375371.3	exon4	c.C1417T	p.R473X	exonic	ENSG00000179002.5	.	stopgain	ENSG00000179002.5:ENST00000375371.3:exon4:c.C1417T:p.R473X	1p36.13	C3L-01662	.	.	.	.	.	.	.	.	rs1020801784	1.6	.	.	.	.	N	A	.	.	.	0.537	.	.	.	.	.	.	.	.	.	T	T	.	.	6.024	35	0.933	N	N	-0.707	0.801	-1.108	0.367	0.001	0.497	0.590	0.563	0.613	.	4.490	-4.640	-1.121	-0.735	-0.900	0.000	0.000	0.000	946	.	.	.	ID=COSV64744730;OCCURENCE=1(large_intestine)	TAS1R2	267	0	610	62	0.0922619047619048	TRUE	TRUE
ENSG00000117152.13	.	BCM	GRCh38.p13	chr1	163072810	163072810	+	G	G	C	Missense_Mutation	SNP	ENST00000367909.10	exon3	c.G155C	p.S52T	exonic	ENSG00000117152.13	.	nonsynonymous SNV	ENSG00000117152.13:ENST00000367909.10:exon3:c.G155C:p.S52T	1q23.3	C3L-01662	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	L	T	N	0.336	T	T	T	0.069	0.414	0.667	0.207	T	T	T	T	D	T	2.109	20.200	0.975	D	D	-0.176	1.946	-0.018	2.300	1.000	0.714	0.590	0.618	0.617	.	4.230	4.230	3.282	1.083	0.674	1.000	0.985	0.956	900	.	.	.	.	RGS4	172	0	360	24	0.0625	TRUE	TRUE
ENSG00000154358.21	.	BCM	GRCh38.p13	chr1	228308308	228308308	+	G	G	A	Missense_Mutation	SNP	ENST00000422127.5	exon47	c.G12664A	p.V4222M	exonic	ENSG00000154358.21	.	nonsynonymous SNV	ENSG00000154358.21:ENST00000422127.5:exon47:c.G12664A:p.V4222M	1q42.13	C3L-01662	1.863e-05	0.0001	0	0	0	1.681e-05	0	0	rs375322738	14.20	D	D	D	D	D	D	H	T	N	0.421	D	D	D	0.455	.	0.753	0.495	T	T	T	D	D	D	3.008	23.400	0.985	D	N	0.674	6.771	0.570	5.872	0.635	0.635	0.574	0.644	0.613	.	6.040	6.040	2.456	1.176	0.676	0.995	0.036	0.019	446	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin_subtype	.	.	ID=COSV52812227;OCCURENCE=1(pancreas)	OBSCN	313	0	630	180	0.222222222222222	TRUE	TRUE
ENSG00000155816.20	.	BCM	GRCh38.p13	chr1	240438178	240438178	+	G	G	A	Nonsense_Mutation	SNP	ENST00000319653.14	exon16	c.G5028A	p.W1676X	exonic	ENSG00000155816.20	.	stopgain	ENSG00000155816.20:ENST00000319653.14:exon16:c.G5028A:p.W1676X	1q43	C3L-01662	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.925	.	.	.	.	.	.	.	.	.	D	D	.	.	10.670	56	0.996	D	N	0.915	11.441	0.797	10.048	1.000	0.554	0.574	0.618	0.621	.	5.910	5.000	9.399	1.176	0.606	1.000	0.999	0.987	945	Formin,_FH2_domain	.	.	ID=COSV60446025;OCCURENCE=1(skin)	FMN2	176	0	383	23	0.0566502463054187	TRUE	TRUE
ENSG00000242580.1	.	BCM	GRCh38.p13	chr2	90210088	90210088	+	T	T	C	Missense_Mutation	SNP	ENST00000468879.1	exon1	c.T35C	p.L12P	exonic	ENSG00000242580.1	.	nonsynonymous SNV	ENSG00000242580.1:ENST00000468879.1:exon1:c.T35C:p.L12P	2p11.2	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGKV1D-43	229	0	503	55	0.0985663082437276	NA	TRUE
ENSG00000115361.8	.	BCM	GRCh38.p13	chr2	210204652	210204652	+	G	G	A	Missense_Mutation	SNP	ENST00000233710.4	exon7	c.C799T	p.R267W	exonic	ENSG00000115361.8	.	nonsynonymous SNV	ENSG00000115361.8:ENST00000233710.4:exon7:c.C799T:p.R267W	2q34	C3L-01662	0.0006	9.654e-05	0.0004	0.0002	0	0.0006	0.0011	0.0012	rs200297060	15.20	D	D	B	B	D	D	M	D	D	0.683	D	D	D	0.705	.	0.987	0.318	T	D	T	D	T	D	2.807	23.000	0.993	D	D	-0.117	2.121	-0.055	2.181	0.395	0.487	0.590	0.574	0.542	.	5.220	3.380	3.654	0.221	-0.208	1.000	0.993	0.983	704	.	.	.	ID=COSV52053772;OCCURENCE=2(large_intestine),1(stomach)	ACADL	347	0	694	99	0.12484237074401	TRUE	TRUE
ENSG00000144451.19	.	BCM	GRCh38.p13	chr2	213284593	213284593	+	C	C	T	Missense_Mutation	SNP	ENST00000331683.10	exon1	c.C110T	p.A37V	exonic	ENSG00000144451.19	.	nonsynonymous SNV	ENSG00000144451.19:ENST00000331683.10:exon1:c.C110T:p.A37V	2q34	C3L-01662	.	.	.	.	.	.	.	.	.	8.20	D	D	D	P	N	D	M	T	N	0.374	T	T	D	0.073	0.496	0.689	0.047	T	T	T	T	D	D	2.580	22.600	0.999	N	N	-0.132	2.076	-0.137	1.946	1.000	0.442	0.522	0.522	0.373	.	4.200	3.310	1.777	1.026	0.549	0.984	0.495	0.792	919	.	.	.	.	SPAG16	117	0	306	32	0.0946745562130177	TRUE	TRUE
ENSG00000155890.4	.	BCM	GRCh38.p13	chr3	140682803	140682803	+	G	G	A	Missense_Mutation	SNP	ENST00000286349.4	exon2	c.G683A	p.R228H	exonic	ENSG00000155890.4	.	nonsynonymous SNV	ENSG00000155890.4:ENST00000286349.4:exon2:c.G683A:p.R228H	3q23	C3L-01662	8.245e-06	0	0	0	0	0	0	6.056e-05	rs766965674	10.20	D	D	D	D	D	D	L	T	N	0.457	T	T	T	0.242	0.501	0.631	0.937	T	T	T	T	D	D	4.180	28.500	1.000	D	D	0.684	6.904	0.679	7.386	0.125	0.487	0.574	0.574	0.564	.	5.200	5.200	6.024	1.176	0.676	1.000	1.000	0.997	561	.	.	.	ID=COSV53883946;OCCURENCE=1(stomach)	TRIM42	215	1	592	53	0.0821705426356589	TRUE	TRUE
ENSG00000145734.19	.	BCM	GRCh38.p13	chr5	71522386	71522386	+	G	G	A	Missense_Mutation	SNP	ENST00000358731.9	exon23	c.G5089A	p.E1697K	exonic	ENSG00000145734.19	.	nonsynonymous SNV	ENSG00000145734.19:ENST00000358731.9:exon23:c.G5089A:p.E1697K	5q13.2	C3L-01662	.	.	.	.	.	.	.	.	.	2.20	T	D	B	B	N	N	L	T	N	0.100	T	T	T	0.026	0.206	0.161	0.044	T	T	T	T	T	T	1.744	17.330	0.990	D	N	-0.319	1.569	-0.344	1.476	0.911	0.651	0.654	0.609	0.684	.	5.210	3.350	2.410	0.228	0.676	0.992	0.038	0.089	434	.	.	.	.	BDP1	227	0	403	32	0.0735632183908046	TRUE	TRUE
ENSG00000175325.2	.	BCM	GRCh38.p13	chr5	177995915	177995915	+	G	G	A	Missense_Mutation	SNP	ENST00000308304.2	exon1	c.C19T	p.R7C	exonic	ENSG00000175325.2	.	nonsynonymous SNV	ENSG00000175325.2:ENST00000308304.2:exon1:c.C19T:p.R7C	5q35.3	C3L-01662	4.125e-05	0	0	0	0	6e-05	0	6.062e-05	rs374712664	2.20	T	D	P	B	N	N	L	D	N	0.099	T	T	T	0.254	.	0.502	0.173	T	T	T	T	T	T	0.587	7.385	0.792	N	N	-1.537	0.070	-1.708	0.049	0.879	0.497	0.590	0.608	0.542	.	2.120	-4.230	-1.065	-1.007	-1.746	0.001	0.059	0.007	929	.	.	.	ID=COSV57645338;OCCURENCE=1(oesophagus),1(biliary_tract)	PROP1	335	0	803	61	0.0706018518518518	TRUE	TRUE
ENSG00000204469.13	.	BCM	GRCh38.p13	chr6	31624471	31624471	+	G	G	T	Missense_Mutation	SNP	ENST00000376033.3	exon5	c.G412T	p.G138W	exonic	ENSG00000204469.13	.	nonsynonymous SNV	ENSG00000204469.13:ENST00000376033.3:exon5:c.G412T:p.G138W	6p21.33	C3L-01662	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.843	T	T	D	0.489	0.625	0.134	0.185	D	T	D	T	D	D	4.482	32	0.956	D	D	0.792	8.630	0.771	9.315	1.000	0.672	0.702	0.702	0.711	.	4.780	4.780	9.143	1.162	0.668	1.000	1.000	1.000	878	BAT2,_N-terminal	.	.	.	PRRC2A	238	0	514	33	0.0603290676416819	TRUE	TRUE
ENSG00000112218.9	.	BCM	GRCh38.p13	chr6	96799500	96799500	+	A	A	T	Missense_Mutation	SNP	ENST00000229955.4	exon2	c.T232A	p.L78M	exonic	ENSG00000112218.9	.	nonsynonymous SNV	ENSG00000112218.9:ENST00000229955.4:exon2:c.T232A:p.L78M	6q16.1	C3L-01662	.	.	.	.	.	.	.	.	.	7.20	D	D	D	D	D	D	L	T	N	0.411	T	T	T	0.155	0.354	0.222	0.483	T	T	T	T	T	T	2.658	22.700	0.975	D	N	-0.417	1.346	-0.576	1.082	0.000	0.707	0.654	0.725	0.564	.	5.150	-3.570	1.736	0.259	-0.208	1.000	0.992	0.983	753	.	.	.	.	GPR63	278	0	573	35	0.0575657894736842	TRUE	TRUE
ENSG00000106571.14	.	BCM	GRCh38.p13	chr7	42023523	42023523	+	T	T	G	Missense_Mutation	SNP	ENST00000395925.8	exon10	c.A1442C	p.N481T	exonic	ENSG00000106571.14	.	nonsynonymous SNV	ENSG00000106571.14:ENST00000395925.8:exon10:c.A1442C:p.N481T	7p14.1	C3L-01662	.	.	.	.	.	.	.	.	.	17.20	D	D	P	B	D	D	M	D	D	0.870	D	D	D	0.587	0.342	0.732	0.622	T	D	D	D	D	D	3.329	24.200	0.992	D	D	0.399	4.338	0.519	5.341	1.000	0.706	0.590	0.710	0.636	.	5.700	5.700	8.017	1.137	0.665	1.000	1.000	0.996	894	Zinc_finger_C2H2-type	.	.	.	GLI3	326	1	838	71	0.0781078107810781	TRUE	TRUE
ENSG00000048405.10	.	BCM	GRCh38.p13	chr7	127373796	127373796	+	T	T	A	Missense_Mutation	SNP	ENST00000265827.8	exon5	c.A1540T	p.I514F	exonic	ENSG00000048405.10	.	nonsynonymous SNV	ENSG00000048405.10:ENST00000265827.8:exon5:c.A1540T:p.I514F	7q31.33	C3L-01662	.	.	.	.	.	.	.	.	.	9.19	D	T	D	D	D	.	N	T	N	0.648	T	T	T	0.391	0.373	0.068	0.468	D	T	T	T	D	D	3.448	24.500	0.971	D	D	0.611	6.042	0.680	7.397	1.000	0.707	0.725	0.651	0.714	.	6.070	6.070	7.674	1.138	0.665	1.000	1.000	1.000	0	.	.	.	.	ZNF800	171	0	318	32	0.0914285714285714	TRUE	TRUE
ENSG00000147485.13	.	BCM	GRCh38.p13	chr8	51475132	51475132	+	A	A	C	Missense_Mutation	SNP	ENST00000356297.5	exon7	c.T534G	p.D178E	exonic	ENSG00000147485.13	.	nonsynonymous SNV	ENSG00000147485.13:ENST00000356297.5:exon7:c.T534G:p.D178E	8q11.22	C3L-01662	.	.	.	.	.	.	.	.	.	4.19	D	T	P	P	.	N	L	T	N	0.497	T	T	T	0.162	0.490	0.215	0.519	T	T	T	T	D	D	1.968	19.010	0.990	D	N	-0.456	1.266	-0.578	1.080	0.000	0.554	0.574	0.618	0.564	.	4.750	-0.471	0.291	0.153	-0.065	0.994	0.805	0.088	912	.	.	.	.	PXDNL	130	0	284	42	0.128834355828221	TRUE	TRUE
ENSG00000047621.12	.	BCM	GRCh38.p13	chr12	4525312	4525312	+	G	G	C	Missense_Mutation	SNP	ENST00000261250.8	exon6	c.C670G	p.Q224E	exonic	ENSG00000047621.12	.	nonsynonymous SNV	ENSG00000047621.12:ENST00000261250.8:exon6:c.C670G:p.Q224E	12p13.32	C3L-01662	.	.	.	.	.	.	.	.	.	10.18	D	T	P	P	D	D	M	.	N	0.738	T	T	T	0.150	0.643	0.458	0.781	.	T	D	D	D	D	3.031	23.500	0.993	D	D	0.587	5.798	0.619	6.467	1.000	0.706	0.710	0.659	0.613	.	5.090	5.090	9.210	1.172	0.672	1.000	1.000	0.994	887	.	.	.	.	C12orf4	263	0	633	57	0.0826086956521739	TRUE	TRUE
ENSG00000185652.12	.	BCM	GRCh38.p13	chr12	5494638	5494638	+	C	C	T	Missense_Mutation	SNP	ENST00000331010.7	exon1	c.C424T	p.H142Y	exonic	ENSG00000185652.12	.	nonsynonymous SNV	ENSG00000185652.12:ENST00000331010.7:exon1:c.C424T:p.H142Y	12p13.31	C3L-01662	.	.	.	.	.	.	.	.	.	14.20	D	T	D	D	D	D	L	T	D	0.625	T	T	D	0.374	0.539	0.461	2.040	T	D	D	D	D	D	3.636	25.200	0.997	D	D	0.717	7.370	0.721	8.168	1.000	0.554	0.590	0.602	0.542	.	5.520	5.520	6.066	1.026	0.549	1.000	0.999	0.991	969	.	.	.	.	NTF3	215	0	571	63	0.0993690851735016	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01662	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	307	1	522	90	0.147058823529412	TRUE	TRUE
ENSG00000126216.15	.	BCM	GRCh38.p13	chr13	112527015	112527015	+	G	G	C	Missense_Mutation	SNP	ENST00000261965.8	exon13	c.C1482G	p.H494Q	exonic	ENSG00000126216.15	.	nonsynonymous SNV	ENSG00000126216.15:ENST00000261965.8:exon13:c.C1482G:p.H494Q	13q34	C3L-01662	.	.	.	.	.	.	.	.	.	5.20	T	D	B	B	D	D	L	T	N	0.829	T	T	T	0.187	0.589	0.781	0.579	T	T	T	T	T	D	2.017	19.380	0.949	D	N	-0.425	1.329	-0.339	1.486	0.997	0.732	0.644	0.744	0.714	.	4.660	0.273	1.646	1.157	0.595	1.000	1.000	0.994	994	.	.	.	.	TUBGCP3	224	0	452	27	0.0563674321503132	TRUE	TRUE
ENSG00000169221.14	.	BCM	GRCh38.p13	chr16	30358470	30358470	+	C	C	T	Missense_Mutation	SNP	ENST00000409939.8	exon9	c.G1901A	p.R634Q	exonic	ENSG00000169221.14	.	nonsynonymous SNV	ENSG00000169221.14:ENST00000409939.8:exon9:c.G1901A:p.R634Q	16p11.2	C3L-01662	2.199e-05	0	0	0	0	0	0	0.0001	rs747731612	12.20	D	T	D	P	D	D	L	D	N	0.141	D	D	D	0.387	0.277	0.359	0.467	T	T	D	D	D	T	3.362	24.300	0.998	D	N	0.290	3.730	0.254	3.462	1.000	0.707	0.702	0.723	0.714	.	4.480	4.480	3.127	1.023	0.544	1.000	1.000	0.997	185	.	.	.	.	TBC1D10B	120	0	401	73	0.154008438818565	TRUE	NA
ENSG00000005156.12	.	BCM	GRCh38.p13	chr17	34991796	34991796	+	G	G	C	Missense_Mutation	SNP	ENST00000378526.9	exon6	c.G1167C	p.K389N	exonic	ENSG00000005156.12	.	nonsynonymous SNV	ENSG00000005156.12:ENST00000378526.9:exon6:c.G1167C:p.K389N	17q12	C3L-01662	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.442	T	T	T	0.165	0.377	0.229	0.703	T	T	T	T	D	D	3.477	24.600	0.999	D	D	0.497	5.009	0.415	4.463	1.000	0.707	0.696	0.698	0.714	.	5.500	2.150	2.503	0.245	0.676	1.000	1.000	0.988	835	DNA_ligase,_ATP-dependent,_N-terminal	.	.	.	LIG3	244	0	516	91	0.1499176276771	TRUE	TRUE
ENSG00000168502.17	.	BCM	GRCh38.p13	chr18	8796305	8796305	+	T	T	A	Missense_Mutation	SNP	ENST00000306329.15	exon7	c.T3041A	p.L1014H	exonic	ENSG00000168502.17	.	nonsynonymous SNV	ENSG00000168502.17:ENST00000306329.15:exon7:c.T3041A:p.L1014H	18p11.22	C3L-01662	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	N	D	M	T	D	0.896	T	T	D	0.419	.	0.432	0.546	T	T	D	D	D	D	3.868	26.200	0.983	D	D	0.569	5.625	0.485	5.023	1.000	0.757	0.563	0.858	0.592	.	5.760	5.760	6.208	1.138	0.665	0.996	0.838	0.906	874	.	.	.	.	MTCL1	390	0	822	50	0.0573394495412844	TRUE	TRUE
ENSG00000188227.13	.	BCM	GRCh38.p13	chr19	37532401	37532401	+	G	G	C	Missense_Mutation	SNP	ENST00000627814.3	exon6	c.G61C	p.E21Q	exonic	ENSG00000188227.13	.	nonsynonymous SNV	ENSG00000188227.13:ENST00000627814.3:exon6:c.G61C:p.E21Q	19q13.12	C3L-01662	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	.	N	H	T	D	0.576	T	T	T	0.257	0.896	0.575	0.305	T	T	T	T	D	D	3.436	24.500	0.998	D	N	0.669	6.709	0.527	5.418	0.006	0.707	0.588	0.725	0.564	.	3.530	3.530	3.754	1.006	0.676	1.000	0.980	0.911	658	Krueppel-associated_box	.	.	.	ZNF793	149	1	340	28	0.0760869565217391	TRUE	TRUE
ENSG00000154736.6	.	BCM	GRCh38.p13	chr21	26934588	26934588	+	G	G	A	Missense_Mutation	SNP	ENST00000284987.6	exon4	c.C1567T	p.R523C	exonic	ENSG00000154736.6	.	nonsynonymous SNV	ENSG00000154736.6:ENST00000284987.6:exon4:c.C1567T:p.R523C	21q21.3	C3L-01662	1.648e-05	0	0	0.0001	0	1.499e-05	0	0	rs759375195	9.20	T	T	B	B	D	D	M	T	N	0.827	T	T	D	0.271	0.581	0.784	1.397	D	T	T	T	D	D	3.724	25.500	0.999	D	D	-0.074	2.260	0.061	2.579	1.000	0.554	0.574	0.602	0.564	.	5.680	3.880	5.991	1.176	0.676	1.000	0.996	0.945	735	ADAM,_cysteine-rich	.	.	ID=COSV53176118;OCCURENCE=1(large_intestine),1(stomach)	ADAMTS5	403	0	896	60	0.0627615062761506	TRUE	TRUE
ENSG00000186951.16	.	BCM	GRCh38.p13	chr22	46215296	46215296	+	G	G	C	Missense_Mutation	SNP	ENST00000407236.5	exon4	c.G332C	p.G111A	exonic	ENSG00000186951.16	.	nonsynonymous SNV	ENSG00000186951.16:ENST00000407236.5:exon4:c.G332C:p.G111A	22q13.31	C3L-01662	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.942	D	D	D	0.981	0.977	0.992	.	D	D	D	D	D	D	3.956	26.700	0.999	D	D	1.039	15.179	0.950	16.061	1.000	0.707	0.725	0.659	0.655	.	5.150	5.150	9.857	1.176	0.618	1.000	0.997	0.990	895	Zinc_finger,_nuclear_hormone_receptor-type	.	.	.	PPARA	483	0	842	177	0.173699705593719	TRUE	TRUE
ENSG00000204267.16	.	BCM	GRCh38.p13	chr6	32837638	32837638	+	G	G	A	Silent	SNP	ENST00000374897.4	exon3	c.C507T	p.I169I	exonic	ENSG00000204267.16;ENSG00000250264.1	.	synonymous SNV	ENSG00000204267.16:ENST00000374897.4:exon3:c.C507T:p.I169I,ENSG00000250264.1:ENST00000452392.2:exon3:c.C507T:p.I169I	6p21.32	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TAP2	457	0	966	58	0.056640625	TRUE	TRUE
ENSG00000127948.16	.	BCM	GRCh38.p13	chr7	75985123	75985123	+	G	G	A	Silent	SNP	ENST00000461988.6	exon12	c.G1314A	p.P438P	exonic	ENSG00000127948.16	.	synonymous SNV	ENSG00000127948.16:ENST00000461988.6:exon12:c.G1314A:p.P438P	7q11.23	C3L-01662	6.95e-05	0	0	0.0004	0	4.765e-05	0	0.0001	rs199937789	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58693818;OCCURENCE=2(large_intestine),1(endometrium)	POR	69	0	248	42	0.144827586206897	TRUE	TRUE
ENSG00000023287.13	.	BCM	GRCh38.p13	chr8	52683645	52683645	+	G	G	C	Silent	SNP	ENST00000025008.10	exon5	c.C273G	p.T91T	exonic	ENSG00000023287.13	.	synonymous SNV	ENSG00000023287.13:ENST00000025008.10:exon5:c.C273G:p.T91T	8q11.23	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RB1CC1	126	0	220	26	0.105691056910569	TRUE	TRUE
ENSG00000164796.18	.	BCM	GRCh38.p13	chr8	112517158	112517158	+	T	T	C	Silent	SNP	ENST00000297405.10	exon28	c.A4632G	p.R1544R	exonic	ENSG00000164796.18	.	synonymous SNV	ENSG00000164796.18:ENST00000297405.10:exon28:c.A4632G:p.R1544R	8q23.3	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CSMD3	272	0	632	51	0.0746705710102489	TRUE	TRUE
ENSG00000165282.14	.	BCM	GRCh38.p13	chr9	35089197	35089197	+	G	G	A	Silent	SNP	ENST00000378617.4	exon11	c.C3165T	p.F1055F	exonic	ENSG00000165282.14	.	synonymous SNV	ENSG00000165282.14:ENST00000378617.4:exon11:c.C3165T:p.F1055F	9p13.3	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PIGO	215	0	507	44	0.0798548094373866	TRUE	TRUE
ENSG00000171505.5	.	BCM	GRCh38.p13	chr9	122526715	122526715	+	G	G	A	Silent	SNP	ENST00000304880.2	exon1	c.C579T	p.N193N	exonic	ENSG00000171505.5	.	synonymous SNV	ENSG00000171505.5:ENST00000304880.2:exon1:c.C579T:p.N193N	9q33.2	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR1N1	277	0	512	39	0.0707803992740472	TRUE	TRUE
ENSG00000117983.17	.	BCM	GRCh38.p13	chr11	1249993	1249993	+	C	C	T	Silent	SNP	ENST00000529681.5	exon31	c.C13113T	p.T4371T	exonic	ENSG00000117983.17	.	synonymous SNV	ENSG00000117983.17:ENST00000529681.5:exon31:c.C13113T:p.T4371T	11p15.5	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC5B	462	0	921	93	0.0917159763313609	NA	TRUE
ENSG00000149043.16	.	BCM	GRCh38.p13	chr11	1837350	1837350	+	C	C	T	Silent	SNP	ENST00000381968.7	exon9	c.C1125T	p.P375P	exonic	ENSG00000149043.16	.	synonymous SNV	ENSG00000149043.16:ENST00000381968.7:exon9:c.C1125T:p.P375P	11p15.5	C3L-01662	9.507e-06	0	0	0	0	1.74e-05	0	0	rs765027292	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53290837;OCCURENCE=1(lung)	SYT8	130	0	309	51	0.141666666666667	TRUE	TRUE
ENSG00000197136.4	.	BCM	GRCh38.p13	chr11	65618985	65618985	+	G	G	C	Silent	SNP	ENST00000355703.3	exon6	c.G1623C	p.L541L	exonic	ENSG00000197136.4	.	synonymous SNV	ENSG00000197136.4:ENST00000355703.3:exon6:c.G1623C:p.L541L	11q13.1	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCNX3	214	0	525	41	0.0724381625441696	TRUE	TRUE
ENSG00000047621.12	.	BCM	GRCh38.p13	chr12	4525331	4525331	+	G	G	A	Silent	SNP	ENST00000261250.8	exon6	c.C651T	p.A217A	exonic	ENSG00000047621.12	.	synonymous SNV	ENSG00000047621.12:ENST00000261250.8:exon6:c.C651T:p.A217A	12p13.32	C3L-01662	8.251e-06	0	0	0	0	0	0	6.058e-05	rs747307280	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C12orf4	252	0	606	50	0.0762195121951219	TRUE	NA
ENSG00000104885.18	.	BCM	GRCh38.p13	chr19	2217777	2217777	+	G	G	C	Silent	SNP	ENST00000398665.8	exon22	c.G2550C	p.L850L	exonic	ENSG00000104885.18	.	synonymous SNV	ENSG00000104885.18:ENST00000398665.8:exon22:c.G2550C:p.L850L	19p13.3	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101288490;OCCURENCE=1(cervix)	DOT1L	117	0	310	18	0.0548780487804878	TRUE	TRUE
ENSG00000050030.15	.	BCM	GRCh38.p13	chrX	74742574	74742574	+	G	G	A	Silent	SNP	ENST00000055682.12	exon3	c.C1983T	p.H661H	exonic	ENSG00000050030.15	.	synonymous SNV	ENSG00000050030.15:ENST00000055682.12:exon3:c.C1983T:p.H661H	Xq13.3	C3L-01662	5.148e-05	0.0001	0	0	0	4.801e-05	0	0.0001	rs138583612	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEXMIF	316	0	484	70	0.126353790613718	TRUE	NA
ENSG00000127241.17	.	BCM	GRCh38.p13	chr3	187236453	187236453	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000127241.17	.	.	.	3q27.3	C3L-01662	2.472e-05	0	0	0	0	4.497e-05	0	0	rs750601815	15.18	D	T	D	D	D	D	.	D	D	0.523	D	D	D	0.609	.	0.904	0.282	T	.	T	D	D	D	4.009	27.000	0.999	D	D	0.564	5.575	0.640	6.759	1.000	0.554	0.590	0.618	0.564	.	5.960	5.960	6.264	1.176	0.676	1.000	0.990	0.866	945	.	.	.	ID=COSV56227201;OCCURENCE=1(endometrium)	MASP1	93	1	459	38	0.0764587525150905	TRUE	NA
ENSG00000170419.10	.	BCM	GRCh38.p13	chr7	54554072	54554072	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000170419.10	.	.	.	7p11.2	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VSTM2A	170	0	328	30	0.0837988826815642	TRUE	NA
ENSG00000104529.17	.	BCM	GRCh38.p13	chr8	143589382	143589382	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000104529.17	.	.	.	8q24.3	C3L-01662	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EEF1D	21	0	89	5	0.0531914893617021	TRUE	NA
ENSG00000104970.11	.	BCM	GRCh38.p13	chr19	54537071	54537071	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000104970.11	.	.	.	19q13.42	C3L-01662	8.28e-06	0	0	0	0	1.498e-05	0	0	rs760842823	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55597926;OCCURENCE=2(large_intestine),1(soft_tissue),2(pancreas),1(lung),1(endometrium)	KIR3DX1	332	0	662	55	0.0767085076708508	TRUE	TRUE
ENSG00000117569.18	.	BCM	GRCh38.p13	chr1	96751440	96751440	+	C	C	G	Missense_Mutation	SNP	ENST00000426398.2	exon3	c.C55G	p.L19V	exonic	ENSG00000117569.18	.	nonsynonymous SNV	ENSG00000117569.18:ENST00000426398.2:exon3:c.C55G:p.L19V	1p21.3	C3N-00709	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	N	0.571	T	T	D	0.179	.	0.515	1.130	D	T	T	T	D	D	3.482	24.700	0.998	D	N	0.616	6.089	0.632	6.653	0.848	0.651	0.709	0.644	0.684	.	5.700	5.700	3.855	1.026	0.599	1.000	1.000	0.996	848	.	.	.	.	PTBP2	163	0	173	37	0.176190476190476	TRUE	TRUE
ENSG00000134250.20	.	BCM	GRCh38.p13	chr1	119968103	119968103	+	G	G	C	Missense_Mutation	SNP	ENST00000256646.7	exon7	c.C1238G	p.T413R	exonic	ENSG00000134250.20	.	nonsynonymous SNV	ENSG00000134250.20:ENST00000256646.7:exon7:c.C1238G:p.T413R	1p12	C3N-00709	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	U	D	N	D	N	0.570	D	D	D	0.513	0.373	0.927	1.612	T	T	D	D	D	D	2.552	22.500	0.991	D	N	0.394	4.306	0.459	4.807	1.000	0.778	0.567	0.780	0.826	.	5.230	5.230	3.235	1.157	0.676	1.000	0.999	0.998	861	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	NOTCH2	527	0	581	141	0.195290858725762	TRUE	TRUE
ENSG00000134389.10	.	BCM	GRCh38.p13	chr1	196984082	196984082	+	A	A	C	Missense_Mutation	SNP	ENST00000256785.5	exon3	c.A375C	p.K125N	exonic	ENSG00000134389.10	.	nonsynonymous SNV	ENSG00000134389.10:ENST00000256785.5:exon3:c.A375C:p.K125N	1q31.3	C3N-00709	8.247e-06	0	0	0	0	1.5e-05	0	0	rs775956342	0.19	T	T	B	B	.	N	N	T	N	0.080	T	T	T	0.029	0.573	0.479	0.016	T	T	T	T	T	T	0.144	2.517	0.082	N	N	-1.552	0.067	-1.557	0.088	0.000	0.487	0.574	0.574	0.564	.	3.890	-2.060	-0.025	-0.387	-0.416	0.000	0.000	0.002	300	Sushi/SCR/CCP_domain	.	.	ID=COSV56818541;OCCURENCE=1(liver)	CFHR5	307	0	456	26	0.0539419087136929	NA	TRUE
ENSG00000154358.21	.	BCM	GRCh38.p13	chr1	228217018	228217018	+	G	G	A	Missense_Mutation	SNP	ENST00000422127.5	exon8	c.G2383A	p.A795T	exonic	ENSG00000154358.21	.	nonsynonymous SNV	ENSG00000154358.21:ENST00000422127.5:exon8:c.G2383A:p.A795T	1q42.13	C3N-00709	0.0002	0	0	0	0	4.776e-05	0	0.0011	rs568901396	1.20	T	T	B	B	N	N	N	T	N	0.148	T	T	D	0.041	0.421	0.315	0.091	T	T	T	T	T	T	-0.671	0.051	0.641	N	N	-1.607	0.053	-1.562	0.086	0.761	0.732	0.574	0.744	0.613	.	4.790	1.150	0.176	-0.460	-1.556	0.000	0.000	0.000	503	.	.	.	ID=COSV52822663;OCCURENCE=1(large_intestine)	OBSCN	120	0	151	35	0.188172043010753	TRUE	TRUE
ENSG00000116031.9	.	BCM	GRCh38.p13	chr2	70835518	70835518	+	C	C	T	Missense_Mutation	SNP	ENST00000410009.5	exon2	c.G163A	p.A55T	exonic	ENSG00000116031.9	.	nonsynonymous SNV	ENSG00000116031.9:ENST00000410009.5:exon2:c.G163A:p.A55T	2p13.3	C3N-00709	3.323e-05	0.0001	0	0	0	3.004e-05	0	6.095e-05	rs781983818	0.20	T	T	B	B	N	N	N	T	N	0.054	T	T	T	0.009	0.217	0.092	0.160	T	T	T	T	T	T	0.206	3.196	0.923	N	N	-1.359	0.135	-1.372	0.166	0.149	0.497	0.590	0.547	0.542	.	4.870	-2.160	-0.990	-0.319	-0.218	0.000	0.001	0.045	876	.	.	.	ID=COSV69651938;OCCURENCE=1(lung)	CD207	331	0	400	71	0.150743099787686	TRUE	TRUE
ENSG00000144381.17	.	BCM	GRCh38.p13	chr2	197494701	197494701	+	C	C	G	Missense_Mutation	SNP	ENST00000388968.8	exon5	c.G562C	p.D188H	exonic	ENSG00000144381.17	.	nonsynonymous SNV	ENSG00000144381.17:ENST00000388968.8:exon5:c.G562C:p.D188H	2q33.1	C3N-00709	.	.	.	.	.	.	.	.	.	16.20	D	D	P	P	D	D	M	T	D	0.477	D	D	D	0.679	0.446	0.635	1.757	T	D	D	D	D	D	3.887	26.300	0.995	D	D	0.732	7.595	0.687	7.521	1.000	0.722	0.663	0.702	0.735	.	5.040	5.040	4.841	1.023	0.549	1.000	1.000	0.997	547	.	.	.	.	HSPD1	242	0	268	43	0.138263665594855	TRUE	TRUE
ENSG00000010282.15	.	BCM	GRCh38.p13	chr3	42697001	42697001	+	G	G	A	Missense_Mutation	SNP	ENST00000441594.6	exon8	c.C1010T	p.T337M	exonic	ENSG00000010282.15	.	nonsynonymous SNV	ENSG00000010282.15:ENST00000441594.6:exon8:c.C1010T:p.T337M	3p22.1	C3N-00709	1.722e-05	0	0	0	0	3.063e-05	0	0	rs773754543	11.20	T	D	D	D	D	D	L	T	N	0.931	T	T	D	0.515	0.678	0.857	0.663	T	T	D	D	T	D	3.264	24.000	0.995	D	D	0.590	5.825	0.544	5.586	1.000	0.497	0.590	0.547	0.542	.	4.320	4.320	9.780	1.083	0.674	1.000	0.965	0.252	397	.	.	.	.	HHATL	88	0	123	16	0.115107913669065	TRUE	NA
ENSG00000010327.10	.	BCM	GRCh38.p13	chr3	52507940	52507940	+	C	C	T	Missense_Mutation	SNP	ENST00000321725.10	exon20	c.C2062T	p.P688S	exonic	ENSG00000010327.10	.	nonsynonymous SNV	ENSG00000010327.10:ENST00000321725.10:exon20:c.C2062T:p.P688S	3p21.1	C3N-00709	.	.	.	.	.	.	.	.	.	12.20	T	D	D	P	D	D	L	D	D	0.366	T	D	D	0.354	0.474	0.788	0.652	T	T	D	T	D	T	2.577	22.600	0.999	D	D	0.059	2.729	0.043	2.511	1.000	0.722	0.547	0.578	0.735	.	4.960	4.960	3.674	1.026	0.599	0.771	0.978	0.948	84	.	.	.	.	STAB1	113	0	124	30	0.194805194805195	TRUE	TRUE
ENSG00000084092.7	.	BCM	GRCh38.p13	chr4	56976532	56976532	+	A	A	C	Missense_Mutation	SNP	ENST00000264230.5	exon1	c.T1054G	p.S352A	exonic	ENSG00000084092.7	.	nonsynonymous SNV	ENSG00000084092.7:ENST00000264230.5:exon1:c.T1054G:p.S352A	4q12	C3N-00709	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.745	D	T	D	0.591	0.860	0.702	0.543	T	T	D	D	D	D	4.156	28.300	0.996	D	D	0.900	11.057	0.756	8.935	1.000	0.628	0.672	0.672	0.658	.	5.680	4.480	7.047	1.302	0.741	1.000	1.000	0.994	855	GTP_binding_domain;Circularly_permuted_(CP)-type_guanine_nucleotide-binding_(G)_domain	.	.	.	NOA1	214	2	248	43	0.147766323024055	TRUE	TRUE
ENSG00000163629.13	.	BCM	GRCh38.p13	chr4	86774520	86774520	+	C	C	T	Missense_Mutation	SNP	ENST00000411767.7	exon33	c.C5497T	p.R1833W	exonic	ENSG00000163629.13	.	nonsynonymous SNV	ENSG00000163629.13:ENST00000411767.7:exon33:c.C5497T:p.R1833W	4q21.3	C3N-00709	4.98e-05	0	0	0.0002	0	3.111e-05	0	0.0001	rs747404195	15.20	D	D	D	D	D	D	M	T	D	0.884	T	T	D	0.563	0.823	0.556	0.263	T	T	D	D	D	D	4.255	29.200	0.999	D	D	0.709	7.242	0.627	6.583	0.993	0.732	0.588	0.744	0.621	.	5.500	4.630	3.372	1.026	0.599	1.000	0.999	0.994	863	PDZ_domain	.	.	.	PTPN13	121	0	134	31	0.187878787878788	TRUE	NA
ENSG00000138646.9	.	BCM	GRCh38.p13	chr4	88499967	88499967	+	A	A	T	Missense_Mutation	SNP	ENST00000264350.8	exon19	c.A2486T	p.E829V	exonic	ENSG00000138646.9	.	nonsynonymous SNV	ENSG00000138646.9:ENST00000264350.8:exon19:c.A2486T:p.E829V	4q22.1	C3N-00709	.	.	.	.	.	.	.	.	.	6.20	D	D	P	D	N	N	M	T	D	0.199	T	T	D	0.279	0.758	0.480	0.489	T	T	T	T	T	T	1.212	13.730	0.904	N	N	-1.022	0.381	-1.335	0.187	1.000	0.732	0.744	0.659	0.621	.	4.490	-8.990	-0.831	-0.279	-0.810	0.292	0.751	0.496	830	HECT_domain	.	.	.	HERC5	98	0	80	15	0.157894736842105	TRUE	TRUE
ENSG00000169570.10	.	BCM	GRCh38.p13	chr5	118840993	118840993	+	A	A	G	Missense_Mutation	SNP	ENST00000510708.6	exon6	c.T821C	p.L274S	exonic	ENSG00000169570.10	.	nonsynonymous SNV	ENSG00000169570.10:ENST00000510708.6:exon6:c.T821C:p.L274S	5q23.1	C3N-00709	.	.	.	.	.	.	.	.	.	7.19	T	T	D	P	D	D	L	.	D	0.342	T	T	T	0.157	0.314	0.713	0.187	T	T	T	T	D	T	3.605	25.100	0.997	D	D	0.463	4.762	0.530	5.444	0.944	0.638	0.670	0.653	0.621	.	5.530	5.530	8.687	1.288	0.756	1.000	1.000	0.998	691	.	.	.	.	DTWD2	270	0	369	69	0.157534246575342	TRUE	TRUE
ENSG00000113248.6	.	BCM	GRCh38.p13	chr5	141246252	141246252	+	C	C	A	Missense_Mutation	SNP	ENST00000231173.6	exon1	c.C674A	p.T225N	exonic	ENSG00000113248.6	.	nonsynonymous SNV	ENSG00000113248.6:ENST00000231173.6:exon1:c.C674A:p.T225N	5q31.3	C3N-00709	.	.	.	.	.	.	.	.	.	7.19	D	D	P	P	.	N	M	T	D	0.157	T	T	D	0.182	0.566	0.689	0.558	T	T	T	T	D	D	2.355	21.900	0.972	N	N	-0.158	1.998	-0.320	1.524	1.000	0.609	0.588	0.731	0.621	.	4.920	4.040	2.116	0.962	0.469	0.209	0.002	0.061	688	Cadherin-like	.	.	.	PCDHB15	257	2	289	59	0.169540229885057	TRUE	NA
ENSG00000112659.14	.	BCM	GRCh38.p13	chr6	43220466	43220466	+	G	G	A	Nonsense_Mutation	SNP	ENST00000252050.9	exon32	c.G6290A	p.W2097X	exonic	ENSG00000112659.14	.	stopgain	ENSG00000112659.14:ENST00000252050.9:exon32:c.G6290A:p.W2097X	6p21.1	C3N-00709	.	.	.	.	.	.	.	.	.	6.6	.	.	.	.	D	A	.	.	.	0.324	.	.	.	.	.	.	.	.	.	D	D	.	.	11.040	58	0.993	D	D	1.026	14.757	0.925	14.846	1.000	0.707	0.644	0.644	0.714	.	5.690	5.690	9.607	1.172	0.672	1.000	1.000	0.996	377	.	.	.	.	CUL9	111	0	314	48	0.132596685082873	TRUE	TRUE
ENSG00000112659.14	.	BCM	GRCh38.p13	chr6	43221738	43221738	+	G	G	A	Nonsense_Mutation	SNP	ENST00000252050.9	exon35	c.G6806A	p.W2269X	exonic	ENSG00000112659.14	.	stopgain	ENSG00000112659.14:ENST00000252050.9:exon35:c.G6806A:p.W2269X	6p21.1	C3N-00709	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.405	.	.	.	.	.	.	.	.	.	D	D	.	.	9.598	51	0.994	D	N	1.022	14.612	0.919	14.567	1.000	0.635	0.644	0.644	0.636	.	5.630	5.630	9.560	1.176	0.676	1.000	1.000	0.999	377	Zinc_finger,_RING-type;IBR_domain	.	.	.	CUL9	134	0	346	68	0.164251207729469	TRUE	NA
ENSG00000106086.20	.	BCM	GRCh38.p13	chr7	30046255	30046255	+	-	NA	AC	Frame_Shift_Ins	INS	ENST00000449726.6	exon3	c.203_204insAC	p.Q69Hfs*6	exonic	ENSG00000106086.20	.	frameshift insertion	ENSG00000106086.20:ENST00000449726.6:exon3:c.203_204insAC:p.Q69Hfs*6	7p14.3	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEKHA8	NA	NA	NA	NA	NA	NA	NA
ENSG00000105851.11	.	BCM	GRCh38.p13	chr7	106868045	106868045	+	G	G	A	Missense_Mutation	SNP	ENST00000496166.6	exon2	c.G484A	p.V162I	exonic	ENSG00000105851.11	.	nonsynonymous SNV	ENSG00000105851.11:ENST00000496166.6:exon2:c.G484A:p.V162I	7q22.3	C3N-00709	.	.	.	.	.	.	.	.	.	6.20	D	T	P	B	N	D	L	T	N	0.465	T	T	T	0.267	0.473	0.443	0.565	T	T	T	T	D	D	2.285	21.500	0.994	D	D	0.406	4.381	0.469	4.889	1.000	0.651	0.709	0.574	0.568	.	5.330	5.330	7.897	1.176	0.618	1.000	0.998	0.904	274	.	.	.	ID=COSV63246379;OCCURENCE=1(liver),3(large_intestine),1(stomach),1(kidney),1(lung)	PIK3CG	142	1	203	25	0.109649122807018	TRUE	TRUE
ENSG00000221866.9	.	BCM	GRCh38.p13	chr7	132508446	132508446	+	G	G	A	Missense_Mutation	SNP	ENST00000359827.7	exon2	c.C248T	p.T83M	exonic	ENSG00000221866.9	.	nonsynonymous SNV	ENSG00000221866.9:ENST00000359827.7:exon2:c.C248T:p.T83M	7q32.3	C3N-00709	0.0001	0	0	0	0.0006	0.0001	0.0011	0.0001	rs199571283	8.20	D	D	D	P	U	D	L	T	D	0.433	T	T	T	0.259	.	0.220	1.334	T	T	T	T	T	D	3.516	24.800	0.998	D	D	0.550	5.447	0.525	5.397	1.000	0.707	0.590	0.618	0.714	.	5.390	5.390	6.429	1.176	0.676	1.000	0.795	0.548	688	Sema_domain	.	.	ID=COSV58102572;OCCURENCE=2(large_intestine),1(stomach),1(kidney),1(urinary_tract),1(lung)	PLXNA4	390	0	671	80	0.106524633821571	TRUE	TRUE
ENSG00000106123.12	.	BCM	GRCh38.p13	chr7	142868321	142868321	+	G	G	T	Missense_Mutation	SNP	ENST00000652003.1	exon14	c.G1999T	p.D667Y	exonic	ENSG00000106123.12	.	nonsynonymous SNV	ENSG00000106123.12:ENST00000652003.1:exon14:c.G1999T:p.D667Y	7q34	C3N-00709	.	.	.	.	.	.	.	.	.	10.14	.	D	.	.	D	D	.	.	.	0.889	T	T	D	0.554	.	0.624	.	T	T	D	D	D	D	4.279	29.400	0.994	D	D	0.782	8.434	0.673	7.274	1.000	0.758	0.616	0.692	0.655	.	4.210	4.210	9.948	1.176	0.676	1.000	0.603	0.704	715	Ephrin_receptor,_transmembrane_domain	.	.	.	EPHB6	542	1	596	131	0.18019257221458	TRUE	TRUE
ENSG00000275591.5	.	BCM	GRCh38.p13	chr8	6811607	6811607	+	G	G	T	Missense_Mutation	SNP	ENST00000618742.3	exon7	c.C1652A	p.A551D	exonic	ENSG00000275591.5	.	nonsynonymous SNV	ENSG00000275591.5:ENST00000618742.3:exon7:c.C1652A:p.A551D	8p23.1	C3N-00709	.	.	.	.	.	.	.	.	.	0.8	.	T	.	.	.	.	L	.	.	0.084	.	.	.	.	.	0.252	.	T	T	T	T	.	T	1.669	16.820	0.527	N	.	.	.	.	.	1.000	0.263	0.166	0.293	0.075	0.123	5.360	2.410	0.384	-0.165	-0.107	0.000	0.000	0.001	994	.	.	.	.	XKR5	170	0	230	52	0.184397163120567	TRUE	TRUE
ENSG00000147647.13	.	BCM	GRCh38.p13	chr8	104392849	104392849	+	C	C	A	Missense_Mutation	SNP	ENST00000351513.7	exon8	c.G1378T	p.G460W	exonic	ENSG00000147647.13	.	nonsynonymous SNV	ENSG00000147647.13:ENST00000351513.7:exon8:c.G1378T:p.G460W	8q22.3	C3N-00709	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.983	D	D	D	0.864	0.890	0.988	0.678	T	D	D	D	D	D	3.993	26.900	0.996	D	D	0.682	6.872	0.717	8.077	1.000	0.554	0.547	0.618	0.613	.	6.020	6.020	7.568	1.026	0.599	1.000	0.789	0.570	551	.	.	.	.	DPYS	556	0	674	142	0.174019607843137	TRUE	TRUE
ENSG00000182197.12	.	BCM	GRCh38.p13	chr8	117822471	117822471	+	T	T	C	Missense_Mutation	SNP	ENST00000378204.7	exon5	c.A1411G	p.N471D	exonic	ENSG00000182197.12	.	nonsynonymous SNV	ENSG00000182197.12:ENST00000378204.7:exon5:c.A1411G:p.N471D	8q24.11	C3N-00709	.	.	.	.	.	.	.	.	.	10.20	T	T	B	B	D	D	N	D	N	0.528	D	D	D	0.321	0.333	0.594	0.460	T	T	T	T	D	D	2.627	22.700	0.993	D	D	-0.157	2.000	0.094	2.711	1.000	0.732	0.634	0.710	0.728	.	6.070	6.070	4.960	1.138	0.660	1.000	1.000	0.999	867	.	.	.	.	EXT1	221	0	311	41	0.116477272727273	TRUE	TRUE
ENSG00000187609.16	.	BCM	GRCh38.p13	chr9	137307035	137307035	+	G	G	A	Missense_Mutation	SNP	ENST00000340951.9	exon22	c.C2546T	p.A849V	exonic	ENSG00000187609.16	.	nonsynonymous SNV	ENSG00000187609.16:ENST00000340951.9:exon22:c.C2546T:p.A849V	9q34.3	C3N-00709	0	0	0	0	0	0	0	0	rs372867176	1.19	T	T	B	B	.	N	N	T	N	0.064	T	T	D	0.061	.	0.105	0.058	T	T	T	T	T	T	0.993	11.540	0.796	N	N	-1.049	0.354	-1.036	0.446	1.000	0.609	0.588	0.769	0.506	.	4.290	2.030	2.880	0.071	0.558	0.541	0.006	0.012	988	.	.	.	.	EXD3	194	1	264	30	0.102040816326531	TRUE	NA
ENSG00000078403.17	.	BCM	GRCh38.p13	chr10	21617134	21617134	+	A	A	G	Missense_Mutation	SNP	ENST00000307729.12	exon8	c.A626G	p.N209S	exonic	ENSG00000078403.17	.	nonsynonymous SNV	ENSG00000078403.17:ENST00000307729.12:exon8:c.A626G:p.N209S	10p12.31	C3N-00709	8.534e-06	0	0	0	0	1.561e-05	0	0	rs768627047	5.20	T	T	B	B	D	D	N	T	N	0.286	T	T	T	0.057	0.408	0.366	0.109	T	T	T	T	D	D	1.887	18.390	0.801	D	N	-0.210	1.850	0.033	2.476	1.000	0.732	0.634	0.659	0.728	.	5.690	5.690	4.642	1.312	0.754	1.000	1.000	0.999	898	.	.	.	.	MLLT10	60	0	69	8	0.103896103896104	TRUE	NA
ENSG00000196932.12	.	BCM	GRCh38.p13	chr10	61410426	61410426	+	T	T	C	Missense_Mutation	SNP	ENST00000399298.8	exon6	c.A1003G	p.S335G	exonic	ENSG00000196932.12	.	nonsynonymous SNV	ENSG00000196932.12:ENST00000399298.8:exon6:c.A1003G:p.S335G	10q21.2	C3N-00709	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	L	.	N	0.076	T	T	T	0.056	0.100	0.092	0.166	T	T	T	T	T	T	0.424	5.692	0.916	N	N	-1.059	0.345	-1.020	0.464	1.000	0.615	0.574	0.616	0.564	.	5.600	1.920	0.138	0.169	-0.203	0.000	0.005	0.003	783	.	.	.	.	TMEM26	357	1	409	82	0.167006109979633	TRUE	TRUE
ENSG00000048540.15	.	BCM	GRCh38.p13	chr12	16600683	16600683	+	G	G	A	Missense_Mutation	SNP	ENST00000537304.6	exon2	c.C178T	p.L60F	exonic	ENSG00000048540.15	.	nonsynonymous SNV	ENSG00000048540.15:ENST00000537304.6:exon2:c.C178T:p.L60F	12p12.3	C3N-00709	.	.	.	.	.	.	.	.	.	18.20	D	D	P	P	D	D	M	D	D	0.447	D	D	D	0.586	0.489	0.956	.	D	D	D	D	D	D	2.839	23.100	0.999	D	D	0.844	9.696	0.852	11.844	1.000	0.615	0.588	0.659	0.564	.	5.720	5.720	9.996	1.176	0.676	1.000	1.000	1.000	909	Zinc_finger,_LIM-type	.	.	.	LMO3	333	0	325	64	0.16452442159383	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-00709	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	305	0	362	67	0.156177156177156	TRUE	TRUE
ENSG00000139304.16	.	BCM	GRCh38.p13	chr12	80493292	80493292	+	G	G	A	Missense_Mutation	SNP	ENST00000644991.3	exon10	c.G1377A	p.M459I	exonic	ENSG00000139304.16	.	nonsynonymous SNV	ENSG00000139304.16:ENST00000644991.3:exon10:c.G1377A:p.M459I	12q21.31	C3N-00709	.	.	.	.	.	.	.	.	.	0.13	.	T	.	.	.	N	.	.	.	0.101	T	T	T	0.092	0.472	0.040	.	T	T	T	T	T	T	0.635	7.848	0.638	N	N	-0.487	1.202	-0.612	1.028	0.017	0.487	0.547	0.574	0.564	.	5.730	-0.600	0.903	0.184	0.676	0.303	0.223	0.462	892	Fibronectin_type_III	.	.	.	PTPRQ	54	0	66	14	0.175	TRUE	TRUE
ENSG00000172766.19	.	BCM	GRCh38.p13	chr13	41367440	41367440	+	-	NA	T	Nonsense_Mutation	SNP	ENST00000379406.8	exon14	c.1542dupT	p.E517*	exonic	ENSG00000172766.19	.	stopgain	ENSG00000172766.19:ENST00000379406.8:exon14:c.1542dupT:p.E517*	13q14.11	C3N-00709	8.463e-06	0	0	0	0	1.538e-05	0	0	rs749241638	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NAA16	NA	NA	NA	NA	NA	NA	NA
ENSG00000136146.15	.	BCM	GRCh38.p13	chr13	48079966	48079966	+	C	C	T	Missense_Mutation	SNP	ENST00000258648.7	exon6	c.G518A	p.R173Q	exonic	ENSG00000136146.15	.	nonsynonymous SNV	ENSG00000136146.15:ENST00000258648.7:exon6:c.G518A:p.R173Q	13q14.2	C3N-00709	.	.	.	.	.	.	.	.	.	19.19	D	D	D	D	D	D	M	.	D	0.711	D	D	D	0.705	0.673	0.648	1.187	D	D	D	D	D	D	4.323	29.800	1.000	D	D	0.873	10.388	0.849	11.718	1.000	0.707	0.725	0.725	0.714	.	5.600	5.600	7.727	1.023	0.599	1.000	0.993	0.916	918	.	.	.	.	MED4	233	0	313	75	0.193298969072165	TRUE	NA
ENSG00000068650.18	.	BCM	GRCh38.p13	chr13	112873581	112873581	+	G	G	T	Missense_Mutation	SNP	ENST00000487903.5	exon27	c.G3066T	p.L1022F	exonic	ENSG00000068650.18	.	nonsynonymous SNV	ENSG00000068650.18:ENST00000487903.5:exon27:c.G3066T:p.L1022F	13q34	C3N-00709	.	.	.	.	.	.	.	.	.	11.20	D	D	P	B	D	D	M	T	D	0.486	T	T	D	0.407	0.507	0.686	0.587	T	T	D	T	D	D	1.224	13.820	0.995	D	N	-0.753	0.726	-0.960	0.541	1.000	0.745	0.750	0.644	0.762	.	4.300	-6.040	0.247	-1.598	-1.216	0.995	0.007	0.018	988	P-type_ATPase,_C-terminal	.	.	.	ATP11A	108	0	139	17	0.108974358974359	TRUE	TRUE
ENSG00000100578.17	.	BCM	GRCh38.p13	chr14	58482672	58482672	+	G	G	A	Missense_Mutation	SNP	ENST00000619416.4	exon22	c.G3059A	p.G1020D	exonic	ENSG00000100578.17	.	nonsynonymous SNV	ENSG00000100578.17:ENST00000619416.4:exon22:c.G3059A:p.G1020D	14q23.1	C3N-00709	0.0015	0	0	0.0184	0.0005	9.027e-05	0	0.0008	rs77860620	0.19	T	T	B	B	N	N	L	T	N	0.129	T	T	.	0.044	.	0.211	0.021	T	T	T	T	T	T	-0.016	1.237	0.140	N	N	-1.021	0.382	-1.045	0.435	0.930	0.744	0.710	0.630	0.613	.	4.330	1.480	-0.289	1.083	0.676	0.000	0.030	0.003	798	.	.	.	ID=COSV54171338;OCCURENCE=1(biliary_tract),2(haematopoietic_and_lymphoid_tissue),1(upper_aerodigestive_tract)	KIAA0586	65	0	106	16	0.131147540983607	TRUE	TRUE
ENSG00000139970.17	.	BCM	GRCh38.p13	chr14	59603875	59603875	+	T	T	C	Missense_Mutation	SNP	ENST00000267484.10	exon6	c.A2159G	p.N720S	exonic	ENSG00000139970.17	.	nonsynonymous SNV	ENSG00000139970.17:ENST00000267484.10:exon6:c.A2159G:p.N720S	14q23.1	C3N-00709	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.888	T	T	D	0.433	0.635	0.302	1.512	T	T	T	T	D	D	3.877	26.200	0.999	D	D	0.742	7.744	0.722	8.187	1.000	0.638	0.588	0.653	0.564	.	5.320	5.320	8.017	1.138	0.665	1.000	1.000	0.989	707	Reticulon	.	.	.	RTN1	177	0	263	40	0.132013201320132	TRUE	TRUE
ENSG00000103313.12	.	BCM	GRCh38.p13	chr16	3254220	3254220	+	G	G	A	Missense_Mutation	SNP	ENST00000219596.5	exon2	c.C848T	p.P283L	exonic	ENSG00000103313.12	.	nonsynonymous SNV	ENSG00000103313.12:ENST00000219596.5:exon2:c.C848T:p.P283L	16p13.3	C3N-00709	8.243e-06	0	0	0	0	1.499e-05	0	0	rs104895119	0.20	T	T	B	B	N	N	N	T	N	0.491	T	T	T	0.308	.	0.321	0.117	T	T	T	T	T	T	-0.332	0.267	0.653	N	N	-1.680	0.040	-1.752	0.041	1.000	0.554	0.588	0.578	0.542	.	3.860	-5.460	-0.801	-0.153	-0.703	0.000	0.423	0.050	784	.	.	.	.	MEFV	492	0	593	103	0.147988505747126	TRUE	NA
ENSG00000005844.18	.	BCM	GRCh38.p13	chr16	30510903	30510903	+	A	A	T	Missense_Mutation	SNP	ENST00000356798.11	exon23	c.A2642T	p.N881I	exonic	ENSG00000005844.18	.	nonsynonymous SNV	ENSG00000005844.18:ENST00000356798.11:exon23:c.A2642T:p.N881I	16p11.2	C3N-00709	.	.	.	.	.	.	.	.	.	8.20	D	D	D	D	N	N	M	T	D	0.473	T	T	D	0.163	0.672	0.749	0.644	T	T	T	T	D	T	1.789	17.650	0.988	N	N	-0.120	2.111	-0.249	1.673	0.948	0.672	0.702	0.547	0.530	.	4.000	4.000	1.809	0.287	0.754	0.033	0.299	0.158	277	Integrin_alpha-2	.	.	.	ITGAL	137	0	175	21	0.107142857142857	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675217	7675219	+	TTG	TTG	-	In_Frame_Del	DEL	ENST00000269305.8	exon5	c.393_395del	p.N131del	exonic	ENSG00000141510.17	.	nonframeshift deletion	ENSG00000141510.17:ENST00000269305.8:exon5:c.393_395del:p.N131del	17p13.1	C3N-00709	.	.	.	.	.	.	.	.	rs879254214	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	285	0	304	85	0.218508997429306	TRUE	TRUE
ENSG00000129657.16	.	BCM	GRCh38.p13	chr17	77206745	77206745	+	T	T	A	Missense_Mutation	SNP	ENST00000436233.9	exon13	c.T1359A	p.D453E	exonic	ENSG00000129657.16	.	nonsynonymous SNV	ENSG00000129657.16:ENST00000436233.9:exon13:c.T1359A:p.D453E	17q25.3	C3N-00709	.	.	.	.	.	.	.	.	.	14.20	D	D	D	P	D	D	M	T	D	0.858	T	T	D	0.401	0.642	0.661	1.389	D	D	D	T	D	D	2.171	20.600	0.995	D	N	0.022	2.589	-0.165	1.873	1.000	0.722	0.699	0.725	0.617	.	4.570	-3.230	-0.005	0.202	-0.128	0.949	1.000	0.982	988	CRAL-TRIO_lipid_binding_domain	.	.	.	SEC14L1	58	0	78	13	0.142857142857143	TRUE	TRUE
ENSG00000180777.14	.	BCM	GRCh38.p13	chr18	14808571	14808571	+	C	C	A	Missense_Mutation	SNP	ENST00000358984.9	exon25	c.C2305A	p.L769I	exonic	ENSG00000180777.14	.	nonsynonymous SNV	ENSG00000180777.14:ENST00000358984.9:exon25:c.C2305A:p.L769I	18p11.21	C3N-00709	.	.	.	.	.	.	.	.	.	1.16	T	T	.	.	.	N	L	T	N	0.258	T	T	D	0.023	0.124	0.072	0.218	.	T	T	T	T	T	0.746	8.874	0.972	N	N	-0.964	0.443	-1.103	0.372	0.000	0.487	0.574	0.574	0.564	.	0.493	0.493	-0.512	-0.684	0.225	0.000	0.000	0.038	923	.	.	.	.	ANKRD30B	164	0	190	28	0.128440366972477	NA	TRUE
ENSG00000105705.16	.	BCM	GRCh38.p13	chr19	19280211	19280218	+	TCTGGGCG	TCTGGGCG	-	Frame_Shift_Del	DEL	ENST00000247001.10	exon9	c.1317_1324del	p.D439Efs*43	exonic	ENSG00000105705.16	.	frameshift deletion	ENSG00000105705.16:ENST00000247001.10:exon9:c.1317_1324del:p.D439Efs*43	19p13.11	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUGP1	156	0	324	56	0.147368421052632	TRUE	TRUE
ENSG00000205076.4	.	BCM	GRCh38.p13	chr19	38771891	38771891	+	C	C	T	Missense_Mutation	SNP	ENST00000378626.4	exon3	c.G235A	p.V79I	exonic	ENSG00000205076.4	.	nonsynonymous SNV	ENSG00000205076.4:ENST00000378626.4:exon3:c.G235A:p.V79I	19q13.2	C3N-00709	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	T	N	0.046	T	T	T	0.018	0.460	0.081	1.419	T	T	T	T	T	.	-0.212	0.482	0.949	N	N	-1.789	0.025	-1.838	0.029	0.998	0.516	0.547	0.577	0.613	.	4.220	-8.450	-2.012	-0.790	-0.477	0.000	0.451	0.027	636	Galectin,_carbohydrate_recognition_domain	.	.	.	LGALS7	138	0	239	23	0.0877862595419847	NA	TRUE
ENSG00000183709.8	.	BCM	GRCh38.p13	chr19	39268763	39268763	+	G	G	A	Missense_Mutation	SNP	ENST00000331982.6	exon2	c.G97A	p.G33R	exonic	ENSG00000183709.8	.	nonsynonymous SNV	ENSG00000183709.8:ENST00000331982.6:exon2:c.G97A:p.G33R	19q13.2	C3N-00709	1.653e-05	0	0	0	0	3.003e-05	0	0	rs368918145	0.20	T	T	B	B	N	N	N	T	N	0.088	T	T	T	0.006	.	0.130	0.372	T	T	T	T	T	T	-1.458	0.001	0.263	N	N	-1.971	0.010	-2.039	0.011	0.186	0.598	0.590	0.596	0.530	.	3.080	-6.150	-2.838	-1.287	-1.051	0.000	0.000	0.001	636	.	.	.	ID=COSV59594208;OCCURENCE=1(skin),1(prostate)	IFNL2	247	0	457	82	0.152133580705009	NA	TRUE
ENSG00000248098.12	.	BCM	GRCh38.p13	chr19	41414074	41414074	+	A	A	G	Missense_Mutation	SNP	ENST00000269980.7	exon4	c.A401G	p.N134S	exonic	ENSG00000248098.12;ENSG00000255730.5	.	nonsynonymous SNV	ENSG00000248098.12:ENST00000269980.7:exon4:c.A401G:p.N134S,ENSG00000255730.5:ENST00000540732.3:exon5:c.A503G:p.N168S	19q13.2	C3N-00709	.	.	.	.	.	.	.	.	.	12.20	T	T	P	B	D	D	N	D	D	0.904	T	T	D	0.587	0.515	0.949	0.293	T	D	D	D	D	D	2.162	20.600	0.636	D	D	0.288	3.720	0.395	4.322	1.000	0.732	0.725	0.744	0.714	.	4.810	4.810	8.567	1.312	0.756	1.000	1.000	0.997	856	Dehydrogenase,_E1_component	.	.	.	BCKDHA	504	0	555	122	0.180206794682422	TRUE	TRUE
ENSG00000104783.14	.	BCM	GRCh38.p13	chr19	43769018	43769018	+	C	C	T	Missense_Mutation	SNP	ENST00000648319.1	exon7	c.G1064A	p.R355Q	exonic	ENSG00000104783.14	.	nonsynonymous SNV	ENSG00000104783.14:ENST00000648319.1:exon7:c.G1064A:p.R355Q	19q13.31	C3N-00709	8.237e-06	0	0	0	0	1.498e-05	0	0	rs200807029	16.20	D	D	D	D	N	D	M	D	N	0.457	D	D	D	0.702	.	0.986	1.591	T	D	D	D	D	D	3.894	26.300	0.999	D	N	0.519	5.186	0.460	4.811	1.000	0.672	0.702	0.590	0.542	.	4.400	4.400	1.006	1.026	0.599	0.008	1.000	0.997	895	Calmodulin-binding_domain	.	.	.	KCNN4	245	0	250	85	0.253731343283582	TRUE	NA
ENSG00000254415.3	.	BCM	GRCh38.p13	chr19	51646407	51646407	+	G	G	A	Missense_Mutation	SNP	ENST00000360844.6	exon2	c.C271T	p.R91C	exonic	ENSG00000254415.3	.	nonsynonymous SNV	ENSG00000254415.3:ENST00000360844.6:exon2:c.C271T:p.R91C	19q13.41	C3N-00709	.	.	.	.	.	.	.	.	.	4.20	T	T	D	P	N	N	L	T	D	0.184	T	T	D	0.132	0.445	0.611	3.640	T	T	T	T	D	T	2.406	22.100	0.997	N	N	-0.197	1.884	-0.380	1.408	0.409	0.615	0.634	0.574	0.564	.	3.190	2.080	0.522	0.896	0.590	0.518	0.039	0.041	982	Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV55784412;OCCURENCE=1(liver),1(stomach),1(upper_aerodigestive_tract)	SIGLEC14	86	0	56	27	0.325301204819277	NA	TRUE
ENSG00000167608.11	.	BCM	GRCh38.p13	chr19	54168639	54168639	+	G	G	A	Missense_Mutation	SNP	ENST00000617472.4	exon4	c.C502T	p.R168C	exonic	ENSG00000167608.11	.	nonsynonymous SNV	ENSG00000167608.11:ENST00000617472.4:exon4:c.C502T:p.R168C	19q13.42	C3N-00709	2.839e-05	0	0	0	0	5.174e-05	0	0	rs764731755	9.17	D	D	.	.	U	D	.	T	D	0.633	T	T	D	0.429	0.711	0.579	.	T	T	D	T	D	T	4.115	27.900	0.999	D	D	0.408	4.391	0.344	3.986	1.000	0.685	0.567	0.674	0.826	.	4.080	3.040	4.338	1.141	0.663	1.000	1.000	0.997	994	.	.	.	.	TMC4	98	0	107	16	0.130081300813008	TRUE	NA
ENSG00000198768.11	.	BCM	GRCh38.p13	chr20	58461013	58461013	+	A	A	T	Missense_Mutation	SNP	ENST00000371149.8	exon4	c.T1283A	p.I428N	exonic	ENSG00000198768.11	.	nonsynonymous SNV	ENSG00000198768.11:ENST00000371149.8:exon4:c.T1283A:p.I428N	20q13.32	C3N-00709	7.416e-05	0	0	0	0	0	0	0.0005	rs149312027	3.20	T	D	B	B	N	N	L	T	N	0.587	T	T	T	0.065	.	0.081	1.297	T	T	T	T	T	D	1.926	18.690	0.961	D	N	-0.227	1.801	-0.187	1.818	0.993	0.615	0.574	0.659	0.542	.	4.220	4.220	2.028	0.248	0.691	0.929	0.603	0.145	489	APCDD1_domain	.	.	.	APCDD1L	228	0	378	102	0.2125	TRUE	TRUE
ENSG00000101162.4	.	BCM	GRCh38.p13	chr20	59024232	59024232	+	G	G	A	Missense_Mutation	SNP	ENST00000217133.2	exon4	c.G805A	p.G269S	exonic	ENSG00000101162.4	.	nonsynonymous SNV	ENSG00000101162.4:ENST00000217133.2:exon4:c.G805A:p.G269S	20q13.32	C3N-00709	.	.	.	.	.	.	.	.	.	11.20	D	T	D	P	N	D	L	D	D	0.869	T	T	D	0.651	.	0.901	0.752	T	D	T	T	D	D	3.505	24.700	0.995	D	D	0.242	3.493	0.220	3.285	1.000	0.537	0.380	0.374	0.509	.	5.340	4.390	9.996	0.198	-0.135	1.000	0.336	0.115	972	Tubulin/FtsZ,_2-layer_sandwich_domain	.	.	.	TUBB1	346	0	405	118	0.225621414913958	TRUE	NA
ENSG00000198445.4	.	BCM	GRCh38.p13	chr22	16592388	16592388	+	C	C	T	Missense_Mutation	SNP	ENST00000359963.4	exon1	c.G163A	p.G55S	exonic	ENSG00000198445.4	.	nonsynonymous SNV	ENSG00000198445.4:ENST00000359963.4:exon1:c.G163A:p.G55S	22q11.1	C3N-00709	7.42e-05	0	0.0008	0	0	0	0	0	rs773674246	13.19	D	D	D	D	U	D	.	D	D	0.671	D	D	D	0.619	0.932	0.666	0.621	T	D	T	D	D	T	2.590	22.600	0.998	N	N	0.207	3.333	-0.006	2.339	0.014	0.487	0.574	0.547	0.564	.	2.000	2.000	3.056	0.688	0.393	0.261	0.177	0.100	994	.	.	.	ID=COSV63461611;OCCURENCE=1(large_intestine)	CCT8L2	293	0	287	71	0.198324022346369	NA	TRUE
ENSG00000102048.16	.	BCM	GRCh38.p13	chrX	15250537	15250537	+	A	A	G	Missense_Mutation	SNP	ENST00000380488.9	exon5	c.T461C	p.I154T	exonic	ENSG00000102048.16	.	nonsynonymous SNV	ENSG00000102048.16:ENST00000380488.9:exon5:c.T461C:p.I154T	Xp22.2	C3N-00709	1.141e-05	0.0001	0	0	0	0	0	0	rs750343277	2.19	T	T	B	B	N	N	M	T	N	0.204	T	T	D	0.273	0.722	0.441	0.336	T	T	T	T	T	T	-0.133	0.707	0.710	N	.	.	.	.	.	0.041	.	.	.	.	.	5.790	-4.170	-0.283	0.042	0.751	0.000	0.000	0.001	314	Ankyrin_repeat-containing_domain	.	.	.	ASB9	96	0	109	53	0.327160493827161	TRUE	NA
ENSG00000068323.17	.	BCM	GRCh38.p13	chrX	49038089	49038089	+	A	A	T	Missense_Mutation	SNP	ENST00000315869.8	exon5	c.T806A	p.I269N	exonic	ENSG00000068323.17	.	nonsynonymous SNV	ENSG00000068323.17:ENST00000315869.8:exon5:c.T806A:p.I269N	Xp11.23	C3N-00709	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	M	T	D	0.549	T	T	D	0.576	0.539	0.752	1.895	D	D	D	D	D	T	3.932	26.500	0.989	D	.	.	.	.	.	1.000	.	.	.	.	.	5.890	5.890	7.399	1.307	0.749	1.000	1.000	1.000	36	.	.	.	.	TFE3	107	0	131	69	0.345	TRUE	TRUE
ENSG00000155659.15	.	BCM	GRCh38.p13	chrX	66033533	66033533	+	T	T	C	Missense_Mutation	SNP	ENST00000374737.9	exon2	c.A353G	p.Q118R	exonic	ENSG00000155659.15	.	nonsynonymous SNV	ENSG00000155659.15:ENST00000374737.9:exon2:c.A353G:p.Q118R	Xq12	C3N-00709	.	.	.	.	.	.	.	.	.	0.19	T	T	P	B	N	N	L	T	N	0.142	T	T	T	0.080	0.416	0.110	0.008	T	T	T	T	T	T	0.788	9.270	0.770	N	.	.	.	.	.	0.999	.	.	.	.	.	4.890	4.890	0.828	1.137	0.665	0.505	0.927	0.137	768	VSIG4,_immunoglobulin_variable_(IgV)-like_domain;Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	VSIG4	72	0	117	7	0.0564516129032258	TRUE	TRUE
ENSG00000196569.12	.	BCM	GRCh38.p13	chr6	129454154	129454154	+	G	G	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000196569.12	ENST00000421865.2:exon47:c.6574-1G>C	.	.	6q22.33	C3N-00709	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.057	35	0.995	D	.	1.259	30.695	1.123	29.994	1.000	0.054	0.060	0.060	0.063	0.984	5.660	5.660	9.602	1.176	0.676	1.000	0.994	0.998	776	.	.	.	ID=COSV101370724;OCCURENCE=1(large_intestine)	LAMA2	184	0	271	46	0.145110410094637	TRUE	TRUE
ENSG00000066135.13	.	BCM	GRCh38.p13	chr1	43667007	43667007	+	C	C	T	Silent	SNP	ENST00000372396.4	exon8	c.C831T	p.A277A	exonic	ENSG00000066135.13	.	synonymous SNV	ENSG00000066135.13:ENST00000372396.4:exon8:c.C831T:p.A277A	1p34.2	C3N-00709	0.0002	0.0002	0	0	0	0	0	0.0011	rs146415834	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KDM4A	283	0	321	64	0.166233766233766	TRUE	NA
ENSG00000143669.14	.	BCM	GRCh38.p13	chr1	235791861	235791861	+	G	G	A	Silent	SNP	ENST00000389793.7	exon12	c.C4381T	p.L1461L	exonic	ENSG00000143669.14	.	synonymous SNV	ENSG00000143669.14:ENST00000389793.7:exon12:c.C4381T:p.L1461L	1q42.3	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LYST	289	0	402	89	0.181262729124236	TRUE	TRUE
ENSG00000071073.13	.	BCM	GRCh38.p13	chr2	98639948	98639948	+	C	C	T	Silent	SNP	ENST00000393487.6	exon12	c.G1182A	p.A394A	exonic	ENSG00000071073.13	.	synonymous SNV	ENSG00000071073.13:ENST00000393487.6:exon12:c.G1182A:p.A394A	2q11.2	C3N-00709	0.0005	0.0050	0.0006	0.0002	0	1.501e-05	0	0	rs140644291	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MGAT4A	129	0	151	34	0.183783783783784	TRUE	NA
ENSG00000206559.8	.	BCM	GRCh38.p13	chr3	28520996	28520996	+	C	C	T	Silent	SNP	ENST00000635992.1	exon5	c.C544T	p.L182L	exonic	ENSG00000206559.8;ENSG00000283563.1	.	synonymous SNV	ENSG00000283563.1:ENST00000635992.1:exon5:c.C544T:p.L182L,ENSG00000206559.8:ENST00000383768.7:exon9:c.C789T:p.V263V	3p24.1	C3N-00709	8.279e-06	0	0	0.0001	0	0	0	0	rs753159242	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZCWPW2	199	0	347	26	0.0697050938337802	TRUE	NA
ENSG00000112659.14	.	BCM	GRCh38.p13	chr6	43220815	43220815	+	G	G	A	Silent	SNP	ENST00000252050.9	exon33	c.G6492A	p.Q2164Q	exonic	ENSG00000112659.14	.	synonymous SNV	ENSG00000112659.14:ENST00000252050.9:exon33:c.G6492A:p.Q2164Q	6p21.1	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CUL9	286	0	729	122	0.143360752056404	TRUE	TRUE
ENSG00000112701.18	.	BCM	GRCh38.p13	chr6	75675889	75675889	+	T	T	C	Silent	SNP	ENST00000447266.7	exon13	c.T1456C	p.L486L	exonic	ENSG00000112701.18	.	synonymous SNV	ENSG00000112701.18:ENST00000447266.7:exon13:c.T1456C:p.L486L	6q14.1	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SENP6	72	0	78	15	0.161290322580645	TRUE	TRUE
ENSG00000135541.21	.	BCM	GRCh38.p13	chr6	135394801	135394801	+	T	T	C	Silent	SNP	ENST00000265602.11	exon23	c.A3084G	p.L1028L	exonic	ENSG00000135541.21	.	synonymous SNV	ENSG00000135541.21:ENST00000265602.11:exon23:c.A3084G:p.L1028L	6q23.3	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AHI1	260	0	358	63	0.149643705463183	TRUE	NA
ENSG00000166886.13	.	BCM	GRCh38.p13	chr12	57091224	57091224	+	C	C	T	Silent	SNP	ENST00000300131.8	exon2	c.C183T	p.F61F	exonic	ENSG00000166886.13	.	synonymous SNV	ENSG00000166886.13:ENST00000300131.8:exon2:c.C183T:p.F61F	12q13.3	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NAB2	42	0	49	9	0.155172413793103	TRUE	TRUE
ENSG00000021645.19	.	BCM	GRCh38.p13	chr14	79280351	79280351	+	G	G	A	Silent	SNP	ENST00000557594.5	exon1	c.G60A	p.G20G	exonic	ENSG00000021645.19	.	synonymous SNV	ENSG00000021645.19:ENST00000557594.5:exon1:c.G60A:p.G20G	14q31.1	C3N-00709	.	.	.	.	.	.	.	.	rs926969351	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55326641;OCCURENCE=1(large_intestine)	NRXN3	282	0	393	48	0.108843537414966	TRUE	TRUE
ENSG00000204103.4	.	BCM	GRCh38.p13	chr20	40688386	40688386	+	C	C	T	Silent	SNP	ENST00000373313.3	exon1	c.G465A	p.L155L	exonic	ENSG00000204103.4	.	synonymous SNV	ENSG00000204103.4:ENST00000373313.3:exon1:c.G465A:p.L155L	20q12	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAFB	98	0	75	5	0.0625	TRUE	NA
ENSG00000180083.11	.	BCM	GRCh38.p13	chr20	45649374	45649374	+	G	G	A	Silent	SNP	ENST00000324384.4	exon4	c.C126T	p.C42C	exonic	ENSG00000180083.11	.	synonymous SNV	ENSG00000180083.11:ENST00000324384.4:exon4:c.C126T:p.C42C	20q13.12	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WFDC11	95	0	149	52	0.258706467661692	TRUE	TRUE
ENSG00000174963.17	.	BCM	GRCh38.p13	chr3	147405440	147405440	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000174963.17	.	.	.	3q24	C3N-00709	.	.	.	.	.	.	.	.	rs768212375	1.13	D	T	.	.	.	.	.	T	N	0.176	T	T	T	0.011	0.206	0.055	.	.	.	T	T	T	T	0.445	5.918	0.870	N	N	-1.155	0.261	-1.277	0.224	0.997	0.447	0.563	0.504	0.530	.	4.300	-0.789	-0.151	-0.681	-0.270	0.000	0.000	0.001	945	.	.	.	.	ZIC4	248	1	373	57	0.132558139534884	TRUE	NA
ENSG00000214035.3	.	BCM	GRCh38.p13	chr7	145010901	145010901	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000214035.3	.	.	.	7q35	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC073310.1	37	0	52	9	0.147540983606557	TRUE	NA
ENSG00000186960.12	.	BCM	GRCh38.p13	chr14	28791953	28791953	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000186960.12	.	.	.	14q12	C3N-00709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC01551	60	0	56	13	0.188405797101449	TRUE	NA
ENSG00000036549.13	.	BCM	GRCh38.p13	chr1	77581871	77581871	+	T	T	C	Missense_Mutation	SNP	ENST00000370801.8	exon8	c.A1813G	p.K605E	exonic	ENSG00000036549.13	.	nonsynonymous SNV	ENSG00000036549.13:ENST00000370801.8:exon8:c.A1813G:p.K605E	1p31.1	C3N-03007	.	.	.	.	.	.	.	.	.	6.15	T	T	.	.	D	D	.	.	N	0.355	T	T	T	0.031	0.177	0.068	0.357	T	.	T	T	D	D	2.721	22.900	0.996	D	D	-0.100	2.174	0.074	2.628	1.000	0.707	0.725	0.609	0.714	.	5.470	5.470	5.853	1.138	0.665	1.000	1.000	0.998	637	.	.	.	.	AC118549.1	125	0	84	6	0.0666666666666667	TRUE	TRUE
ENSG00000118965.15	.	BCM	GRCh38.p13	chr2	19930549	19930549	+	T	T	A	Missense_Mutation	SNP	ENST00000345530.7	exon26	c.A3001T	p.T1001S	exonic	ENSG00000118965.15	.	nonsynonymous SNV	ENSG00000118965.15:ENST00000345530.7:exon26:c.A3001T:p.T1001S	2p24.1	C3N-03007	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.225	T	T	T	0.042	0.278	0.545	0.102	T	T	T	T	T	T	1.717	17.140	0.969	D	N	-0.486	1.205	-0.272	1.623	0.163	0.707	0.654	0.725	0.636	.	5.200	4.020	2.656	1.118	0.665	1.000	0.981	0.985	950	.	.	.	.	WDR35	314	0	287	30	0.0946372239747634	TRUE	TRUE
ENSG00000065802.12	.	BCM	GRCh38.p13	chr2	238435859	238435859	+	G	G	A	Missense_Mutation	SNP	ENST00000264607.9	exon3	c.G340A	p.A114T	exonic	ENSG00000065802.12	.	nonsynonymous SNV	ENSG00000065802.12:ENST00000264607.9:exon3:c.G340A:p.A114T	2q37.3	C3N-03007	.	.	.	.	.	.	.	.	.	15.20	D	D	D	P	D	D	M	T	N	0.831	D	D	D	0.547	0.668	0.843	1.349	T	T	D	D	D	D	3.986	26.900	0.999	D	D	0.859	10.045	0.799	10.081	1.000	0.719	0.725	0.723	0.714	.	5.580	5.580	5.797	1.176	0.676	1.000	0.983	0.954	964	Ankyrin_repeat-containing_domain	.	.	.	ASB1	363	0	316	59	0.157333333333333	TRUE	TRUE
ENSG00000159650.9	.	BCM	GRCh38.p13	chr3	126508001	126508001	+	C	C	T	Missense_Mutation	SNP	ENST00000290868.7	exon5	c.G506A	p.R169H	exonic	ENSG00000159650.9	.	nonsynonymous SNV	ENSG00000159650.9:ENST00000290868.7:exon5:c.G506A:p.R169H	3q21.3	C3N-03007	4.952e-05	9.653e-05	8.643e-05	0	0	6.01e-05	0	0	rs369545977	7.20	D	D	P	B	D	N	M	T	N	0.273	T	T	T	0.119	.	0.597	0.111	T	T	T	T	T	D	1.830	17.950	0.996	D	D	-0.202	1.871	-0.287	1.590	0.554	0.487	0.574	0.547	0.613	.	3.910	3.030	1.624	-0.319	-1.388	0.971	0.026	0.004	843	Urocanase,_N-terminal_domain	.	.	ID=COSV52029861;OCCURENCE=1(skin),1(thyroid)	UROC1	246	0	224	13	0.0548523206751055	NA	TRUE
ENSG00000047662.5	.	BCM	GRCh38.p13	chr4	17639344	17639344	+	G	G	T	Missense_Mutation	SNP	ENST00000265018.4	exon14	c.C2572A	p.R858S	exonic	ENSG00000047662.5	.	nonsynonymous SNV	ENSG00000047662.5:ENST00000265018.4:exon14:c.C2572A:p.R858S	4p15.32	C3N-03007	.	.	.	.	.	.	.	.	.	4.20	T	D	P	P	D	N	L	T	N	0.305	T	T	D	0.095	0.179	0.088	.	T	T	T	T	D	T	3.511	24.700	0.997	N	N	0.168	3.165	0.168	3.030	0.212	0.660	0.514	0.696	0.714	.	5.020	4.080	3.361	1.083	0.618	0.882	0.494	0.372	661	.	.	.	.	FAM184B	261	0	213	20	0.0858369098712446	TRUE	TRUE
ENSG00000169435.14	.	BCM	GRCh38.p13	chr4	73585190	73585190	+	T	T	C	Missense_Mutation	SNP	ENST00000342081.7	exon6	c.A653G	p.Y218C	exonic	ENSG00000169435.14	.	nonsynonymous SNV	ENSG00000169435.14:ENST00000342081.7:exon6:c.A653G:p.Y218C	4q13.3	C3N-03007	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.960	T	T	D	0.621	0.663	0.517	0.018	T	T	D	D	D	D	4.337	29.900	0.998	D	D	0.784	8.475	0.721	8.162	1.000	0.554	0.588	0.547	0.564	.	5.910	5.910	6.465	1.138	0.665	1.000	1.000	0.961	838	Ras-associating_(RA)_domain	.	.	.	RASSF6	74	0	48	4	0.0769230769230769	NA	TRUE
ENSG00000204956.5	.	BCM	GRCh38.p13	chr5	141332728	141332728	+	G	G	A	Missense_Mutation	SNP	ENST00000517417.2	exon1	c.G2044A	p.A682T	exonic	ENSG00000204956.5	.	nonsynonymous SNV	ENSG00000204956.5:ENST00000517417.2:exon1:c.G2044A:p.A682T	5q31.3	C3N-03007	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	T	N	0.024	T	T	T	0.033	0.221	0.366	0.281	.	T	T	T	T	T	0.091	2.008	0.877	N	N	-1.223	0.211	-1.305	0.206	0.043	0.549	0.574	0.602	0.616	.	3.870	-2.850	-2.036	-0.167	0.608	0.000	0.000	0.001	474	.	.	.	ID=COSV65298235;OCCURENCE=2(thyroid)	PCDHGA1	516	0	451	43	0.0870445344129555	NA	TRUE
ENSG00000074276.10	.	BCM	GRCh38.p13	chr5	176565690	176565690	+	C	C	T	Missense_Mutation	SNP	ENST00000510636.5	exon3	c.C71T	p.P24L	exonic	ENSG00000074276.10	.	nonsynonymous SNV	ENSG00000074276.10:ENST00000510636.5:exon3:c.C71T:p.P24L	5q35.2	C3N-03007	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	.	D	M	D	D	0.872	D	D	D	0.719	0.639	0.759	0.646	T	T	D	D	D	T	3.118	23.700	0.997	D	D	0.618	6.115	0.393	4.312	1.000	0.497	0.590	0.578	0.613	.	4.800	4.800	4.145	1.026	0.599	0.879	0.009	0.040	373	.	.	.	.	CDHR2	218	0	178	12	0.0631578947368421	TRUE	NA
ENSG00000118491.10	.	BCM	GRCh38.p13	chr6	143937654	143937654	+	G	G	A	Missense_Mutation	SNP	ENST00000237275.9	exon7	c.G604A	p.A202T	exonic	ENSG00000118491.10	.	nonsynonymous SNV	ENSG00000118491.10:ENST00000237275.9:exon7:c.G604A:p.A202T	6q24.2	C3N-03007	.	.	.	.	.	.	.	.	.	2.19	D	D	B	B	.	N	L	T	N	0.084	T	T	T	0.030	0.134	0.055	.	T	T	T	T	T	T	2.052	19.650	0.998	N	N	-0.648	0.902	-0.565	1.100	0.998	0.554	0.588	0.492	0.542	.	5.130	2.140	0.343	1.176	0.618	0.069	0.991	0.997	887	.	.	.	.	ZC2HC1B	111	0	75	5	0.0625	TRUE	TRUE
ENSG00000186340.15	.	BCM	GRCh38.p13	chr6	169248865	169248865	+	G	G	T	Missense_Mutation	SNP	ENST00000366787.7	exon4	c.C161A	p.A54D	exonic	ENSG00000186340.15	.	nonsynonymous SNV	ENSG00000186340.15:ENST00000366787.7:exon4:c.C161A:p.A54D	6q27	C3N-03007	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	U	D	M	T	D	0.882	T	T	T	0.458	0.821	0.653	2.209	T	D	D	D	D	D	3.297	24.100	0.995	D	D	0.510	5.114	0.401	4.365	1.000	0.706	0.574	0.710	0.613	.	4.420	4.420	9.322	1.121	0.676	1.000	0.006	0.003	994	Laminin_G_domain	.	.	.	THBS2	180	0	151	11	0.0679012345679012	TRUE	TRUE
ENSG00000158528.12	.	BCM	GRCh38.p13	chr7	94911424	94911424	+	G	G	A	Missense_Mutation	SNP	ENST00000433881.5	exon2	c.G1311A	p.M437I	exonic	ENSG00000158528.12	.	nonsynonymous SNV	ENSG00000158528.12:ENST00000433881.5:exon2:c.G1311A:p.M437I	7q21.3	C3N-03007	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	L	T	N	0.404	T	T	T	0.070	0.247	0.398	0.184	T	T	T	T	T	D	1.735	17.270	0.940	D	N	-0.103	2.165	0.029	2.462	0.999	0.653	0.574	0.676	0.542	.	5.550	5.550	3.060	1.176	0.676	1.000	0.781	0.027	452	.	.	.	ID=COSV56893578;OCCURENCE=1(skin)	PPP1R9A	180	0	138	15	0.0980392156862745	TRUE	TRUE
ENSG00000104714.14	.	BCM	GRCh38.p13	chr8	731143	731143	+	G	G	A	Missense_Mutation	SNP	ENST00000262109.8	exon1	c.C19T	p.H7Y	exonic	ENSG00000104714.14	.	nonsynonymous SNV	ENSG00000104714.14:ENST00000262109.8:exon1:c.C19T:p.H7Y	8p23.3	C3N-03007	.	.	.	.	.	.	.	.	.	2.20	D	D	P	P	U	N	N	T	N	0.343	T	T	T	0.059	.	0.418	0.011	T	T	T	T	T	T	2.165	20.600	0.979	N	N	-0.408	1.366	-0.515	1.178	1.000	0.442	0.522	0.522	0.562	.	2.250	2.250	0.522	0.954	0.578	0.003	0.022	0.030	981	.	.	.	.	ERICH1	148	0	114	12	0.0952380952380952	TRUE	TRUE
ENSG00000104447.12	.	BCM	GRCh38.p13	chr8	115604820	115604820	+	C	C	A	Missense_Mutation	SNP	ENST00000640765.1	exon3	c.G1110T	p.E370D	exonic	ENSG00000104447.12	.	nonsynonymous SNV	ENSG00000104447.12:ENST00000640765.1:exon3:c.G1110T:p.E370D	8q23.3	C3N-03007	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	N	N	D	N	0.079	T	T	T	0.228	0.157	0.182	0.084	T	T	T	T	T	T	1.145	13.190	0.981	D	N	-0.458	1.262	-0.235	1.705	0.998	0.638	0.588	0.653	0.621	.	5.690	3.840	1.431	1.026	0.599	0.997	0.981	0.840	940	.	.	.	.	TRPS1	280	1	247	13	0.05	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971125	21971126	+	GA	GA	-	Frame_Shift_Del	DEL	ENST00000304494.9	exon2	c.233_234del	p.L78Hfs*41	exonic	ENSG00000147889.17	.	frameshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.233_234del:p.L78Hfs*41	9p21.3	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	635	2	422	60	0.12448132780083	NA	TRUE
ENSG00000148408.13	.	BCM	GRCh38.p13	chr9	138102715	138102715	+	C	C	T	Missense_Mutation	SNP	ENST00000371372.6	exon38	c.C5227T	p.R1743C	exonic	ENSG00000148408.13	.	nonsynonymous SNV	ENSG00000148408.13:ENST00000371372.6:exon38:c.C5227T:p.R1743C	9q34.3	C3N-03007	1.796e-05	0.0002	0	0	0	0	0	0	rs370345897	20.20	D	D	D	D	D	D	M	D	D	0.681	D	D	D	0.921	.	0.976	3.148	D	D	D	D	D	D	4.544	32	0.999	D	D	0.768	8.189	0.700	7.760	0.999	0.615	0.547	0.616	0.613	.	4.710	4.710	6.045	1.025	0.598	1.000	1.000	0.998	994	EF-hand_domain;Voltage-dependent_L-type_calcium_channel,_IQ-associated_domain	.	.	ID=COSV53113250;OCCURENCE=1(cervix),1(large_intestine)	CACNA1B	43	0	20	6	0.230769230769231	TRUE	TRUE
ENSG00000279012.2	.	BCM	GRCh38.p13	chr11	5324163	5324163	+	G	G	T	Nonsense_Mutation	SNP	ENST00000624187.1	exon1	c.C135A	p.Y45X	exonic	ENSG00000279012.2	.	stopgain	ENSG00000279012.2:ENST00000624187.1:exon1:c.C135A:p.Y45X	11p15.4	C3N-03007	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	U	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.178	28.500	0.992	N	N	-0.019	2.445	-0.359	1.448	0.001	0.487	0.574	0.574	0.564	.	4.390	-1.450	-2.090	-0.224	-1.059	0.000	0.800	0.001	873	GPCR,_rhodopsin-like,_7TM	.	.	.	OR51B2	239	0	164	14	0.0786516853932584	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-03007	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	250	0	175	32	0.154589371980676	TRUE	TRUE
ENSG00000072041.17	.	BCM	GRCh38.p13	chr12	84861775	84861775	+	C	C	T	Missense_Mutation	SNP	ENST00000266682.10	exon12	c.G2050A	p.E684K	exonic	ENSG00000072041.17	.	nonsynonymous SNV	ENSG00000072041.17:ENST00000266682.10:exon12:c.G2050A:p.E684K	12q21.31	C3N-03007	.	.	.	.	.	.	.	.	rs1006033978	13.20	D	D	D	P	N	D	M	T	N	0.779	T	D	D	0.354	0.364	0.833	0.702	T	T	D	D	D	D	3.168	23.800	0.999	D	D	0.573	5.662	0.557	5.726	1.000	0.638	0.574	0.653	0.564	.	5.850	5.850	7.447	1.026	0.599	1.000	0.351	0.011	877	.	.	.	ID=COSV57019783;OCCURENCE=2(large_intestine),1(stomach),1(pancreas),1(skin)	SLC6A15	115	0	72	9	0.111111111111111	TRUE	TRUE
ENSG00000100448.4	.	BCM	GRCh38.p13	chr14	24574740	24574740	+	G	G	A	Missense_Mutation	SNP	ENST00000216336.3	exon3	c.C274T	p.R92C	exonic	ENSG00000100448.4	.	nonsynonymous SNV	ENSG00000100448.4:ENST00000216336.3:exon3:c.C274T:p.R92C	14q12	C3N-03007	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	N	N	L	D	D	0.185	T	D	D	0.199	0.540	0.929	0.673	T	D	T	T	D	T	2.270	21.400	0.996	N	N	-0.472	1.233	-0.692	0.912	0.014	0.487	0.574	0.574	0.564	.	4.480	0.459	-0.889	1.176	-0.148	0.000	0.322	0.012	424	Serine_proteases,_trypsin_domain	.	.	ID=COSV53535447;OCCURENCE=1(central_nervous_system),1(prostate)	CTSG	349	0	326	31	0.0868347338935574	TRUE	TRUE
ENSG00000119630.14	.	BCM	GRCh38.p13	chr14	74946760	74946760	+	C	C	A	Missense_Mutation	SNP	ENST00000405431.2	exon5	c.G581T	p.G194V	exonic	ENSG00000119630.14	.	nonsynonymous SNV	ENSG00000119630.14:ENST00000405431.2:exon5:c.G581T:p.G194V	14q24.3	C3N-03007	.	.	.	.	.	.	.	.	.	1.14	D	T	.	.	.	N	.	.	N	0.240	T	T	T	0.082	0.219	0.200	.	.	T	T	T	T	T	0.559	7.107	0.931	N	N	-0.586	1.013	-0.777	0.790	1.000	0.609	0.682	0.618	0.655	.	3.560	-1.830	0.350	0.122	0.596	0.000	0.125	0.178	447	.	.	.	.	PGF	92	1	72	10	0.121951219512195	TRUE	TRUE
ENSG00000137877.10	.	BCM	GRCh38.p13	chr15	41871396	41871396	+	C	C	T	Missense_Mutation	SNP	ENST00000320955.8	exon29	c.G5426A	p.R1809H	exonic	ENSG00000137877.10	.	nonsynonymous SNV	ENSG00000137877.10:ENST00000320955.8:exon29:c.G5426A:p.R1809H	15q15.1	C3N-03007	0.0003	0	0.0029	0	0	0.0001	0	0	rs757454069	0.20	T	T	B	B	N	N	N	T	N	0.070	T	T	T	0.033	0.475	0.353	.	T	T	T	T	T	T	-0.731	0.037	0.868	N	N	-1.644	0.046	-1.705	0.050	1.000	0.563	0.610	0.576	0.636	.	4.700	-5.410	-1.580	-1.314	-1.573	0.000	0.005	0.025	197	.	.	.	.	SPTBN5	77	0	45	6	0.117647058823529	TRUE	NA
ENSG00000169594.13	.	BCM	GRCh38.p13	chr15	83264116	83264116	+	C	C	T	Missense_Mutation	SNP	ENST00000345382.6	exon4	c.G1135A	p.V379I	exonic	ENSG00000169594.13	.	nonsynonymous SNV	ENSG00000169594.13:ENST00000345382.6:exon4:c.G1135A:p.V379I	15q25.2	C3N-03007	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	N	0.662	T	T	T	0.197	0.300	0.402	0.565	D	T	T	T	D	D	3.572	24.900	0.999	D	D	0.914	11.430	0.890	13.312	1.000	0.638	0.563	0.653	0.636	.	5.750	5.750	7.842	1.026	0.599	1.000	0.994	0.975	430	Zinc_finger_C2H2-type	.	.	ID=COSV61756473;OCCURENCE=1(large_intestine),1(endometrium)	BNC1	226	0	168	20	0.106382978723404	TRUE	TRUE
ENSG00000168140.5	.	BCM	GRCh38.p13	chr16	4381829	4381829	+	G	G	A	Missense_Mutation	SNP	ENST00000304735.4	exon2	c.G952A	p.V318I	exonic	ENSG00000168140.5	.	nonsynonymous SNV	ENSG00000168140.5:ENST00000304735.4:exon2:c.G952A:p.V318I	16p13.3	C3N-03007	2.714e-05	0	0	0.0001	0	0	0	0.0001	rs755829190	3.19	T	T	B	B	N	D	N	T	N	0.040	T	T	D	0.104	0.269	0.406	0.062	T	T	T	T	T	.	1.051	12.250	0.948	D	N	-0.743	0.742	-0.669	0.944	1.000	0.696	0.551	0.723	0.605	.	5.670	-0.567	1.950	0.215	0.604	0.945	0.005	0.888	576	Cysteine-rich_flanking_region,_C-terminal	.	.	ID=COSV52030715;OCCURENCE=1(large_intestine)	VASN	235	0	256	24	0.0857142857142857	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674257	7674257	+	A	A	G	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.T706C	p.Y236H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.T706C:p.Y236H	17p13.1	C3N-03007	.	.	.	.	.	.	.	.	rs587782289	18.20	D	D	D	D	N	D	M	D	D	0.658	D	D	D	0.772	0.903	0.944	0.432	T	D	D	D	D	D	4.611	32	0.998	D	D	0.596	5.888	0.546	5.607	0.081	0.722	0.702	0.725	0.735	.	4.620	3.540	9.312	1.305	0.751	1.000	1.000	1.000	433	p53,_DNA-binding_domain	.	.	ID=COSV52783032;OCCURENCE=1(breast),1(liver),2(large_intestine),1(biliary_tract),2(ovary),2(haematopoietic_and_lymphoid_tissue),1(pancreas),3(skin),1(prostate),2(lung),3(upper_aerodigestive_tract),1(eye)	TP53	365	0	263	34	0.114478114478114	TRUE	TRUE
ENSG00000213417.3	.	BCM	GRCh38.p13	chr17	41065769	41065769	+	C	C	T	Missense_Mutation	SNP	ENST00000394015.3	exon1	c.G77A	p.R26H	exonic	ENSG00000213417.3	.	nonsynonymous SNV	ENSG00000213417.3:ENST00000394015.3:exon1:c.G77A:p.R26H	17q21.2	C3N-03007	.	.	.	.	.	.	.	.	.	2.16	T	T	.	.	U	N	.	T	N	0.318	T	T	T	0.194	0.479	0.380	0.717	T	T	T	T	D	.	2.712	22.900	0.992	D	N	0.139	3.044	0.160	2.995	0.691	0.487	0.590	0.547	0.564	.	5.270	4.290	1.271	1.007	0.507	0.940	0.972	0.980	407	.	.	.	.	KRTAP2-4	157	0	150	24	0.137931034482759	NA	TRUE
ENSG00000170703.15	.	BCM	GRCh38.p13	chr17	48786300	48786300	+	T	T	C	Missense_Mutation	SNP	ENST00000393382.7	exon12	c.A1625G	p.K542R	exonic	ENSG00000170703.15	.	nonsynonymous SNV	ENSG00000170703.15:ENST00000393382.7:exon12:c.A1625G:p.K542R	17q21.32	C3N-03007	.	.	.	.	.	.	.	.	.	2.13	.	T	.	.	N	N	.	T	.	0.296	T	T	T	0.221	.	0.085	0.339	T	.	T	T	D	.	2.010	19.330	0.996	D	N	-0.145	2.037	-0.145	1.924	0.004	0.615	0.627	0.659	0.530	.	5.630	3.390	3.499	1.138	0.665	0.998	0.330	0.087	452	.	.	.	.	TTLL6	219	0	233	18	0.0717131474103586	TRUE	TRUE
ENSG00000124089.4	.	BCM	GRCh38.p13	chr20	56248940	56248940	+	G	G	A	Missense_Mutation	SNP	ENST00000243911.2	exon1	c.G97A	p.A33T	exonic	ENSG00000124089.4	.	nonsynonymous SNV	ENSG00000124089.4:ENST00000243911.2:exon1:c.G97A:p.A33T	20q13.2	C3N-03007	8.244e-06	0	0	0.0001	0	0	0	0	rs770261378	0.18	T	T	.	.	N	N	N	T	N	0.052	T	T	T	0.300	.	0.410	0.151	T	T	T	T	T	T	-0.112	0.785	0.746	N	N	-1.337	0.146	-1.326	0.192	0.000	0.447	0.547	0.563	0.613	.	5.010	-1.940	0.852	-0.588	-0.754	0.005	0.065	0.540	982	.	.	.	ID=COSV54763474;OCCURENCE=1(liver),1(pancreas),1(endometrium)	MC3R	291	0	266	22	0.0763888888888889	TRUE	TRUE
ENSG00000154734.15	.	BCM	GRCh38.p13	chr21	26842526	26842526	+	C	C	T	Missense_Mutation	SNP	ENST00000284984.8	exon2	c.G890A	p.S297N	exonic	ENSG00000154734.15	.	nonsynonymous SNV	ENSG00000154734.15:ENST00000284984.8:exon2:c.G890A:p.S297N	21q21.3	C3N-03007	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	.	D	M	D	D	0.915	D	D	D	0.600	0.733	0.639	0.850	T	T	D	T	D	D	3.931	26.500	0.998	D	D	0.761	8.059	0.743	8.639	1.000	0.628	0.574	0.672	0.639	.	5.440	5.440	4.495	1.026	0.599	1.000	1.000	0.999	828	Peptidase_M12B,_ADAM/reprolysin	.	.	.	ADAMTS1	418	0	346	25	0.0673854447439353	TRUE	TRUE
ENSG00000156299.13	.	BCM	GRCh38.p13	chr21	31225898	31225898	+	C	C	T	Missense_Mutation	SNP	ENST00000286827.7	exon8	c.G1637A	p.C546Y	exonic	ENSG00000156299.13	.	nonsynonymous SNV	ENSG00000156299.13:ENST00000286827.7:exon8:c.G1637A:p.C546Y	21q22.11	C3N-03007	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.931	T	T	D	0.507	0.674	0.678	2.102	T	D	D	D	D	D	3.458	24.600	0.987	D	D	0.520	5.193	0.428	4.560	1.000	0.706	0.588	0.710	0.564	.	4.500	4.500	7.883	1.026	0.599	1.000	0.469	0.214	860	Pleckstrin_homology_domain	.	.	ID=COSV99734315;OCCURENCE=1(lung)	TIAM1	289	0	253	15	0.0559701492537313	TRUE	TRUE
ENSG00000183337.17	.	BCM	GRCh38.p13	chrX	40072815	40072815	+	G	G	A	Missense_Mutation	SNP	ENST00000378444.9	exon4	c.C2531T	p.P844L	exonic	ENSG00000183337.17	.	nonsynonymous SNV	ENSG00000183337.17:ENST00000378444.9:exon4:c.C2531T:p.P844L	Xp11.4	C3N-03007	2.283e-05	0.0001	0	0	0.0002	0	0	0	rs140780988	5.18	D	D	P	B	.	N	L	T	D	0.274	T	T	D	0.103	.	0.311	0.270	T	T	T	T	T	T	1.640	16.630	0.965	D	.	.	.	.	.	1.000	.	.	.	.	.	5.930	4.000	3.087	1.176	0.676	0.998	0.028	0.430	912	.	.	.	.	BCOR	116	1	94	16	0.145454545454545	TRUE	NA
ENSG00000250423.2	.	BCM	GRCh38.p13	chrX	119087341	119087341	+	G	G	A	Missense_Mutation	SNP	ENST00000402510.2	exon11	c.C3889T	p.L1297F	exonic	ENSG00000250423.2	.	nonsynonymous SNV	ENSG00000250423.2:ENST00000402510.2:exon11:c.C3889T:p.L1297F	Xq24	C3N-03007	.	.	.	.	.	.	.	.	.	0.18	T	T	P	B	.	N	N	T	N	0.103	T	T	T	0.014	0.192	0.055	0.034	T	T	T	T	T	T	-0.615	0.068	0.981	N	.	.	.	.	.	0.989	.	.	.	.	.	3.970	-5.480	-0.561	-0.633	-0.699	0.000	0.005	0.010	498	.	.	.	.	KIAA1210	90	0	130	10	0.0714285714285714	TRUE	TRUE
ENSG00000138381.10	.	BCM	GRCh38.p13	chr2	189667835	189667835	+	G	G	A	Silent	SNP	ENST00000260952.9	exon5	c.G1536A	p.S512S	exonic	ENSG00000138381.10;ENSG00000286165.1	.	synonymous SNV	ENSG00000138381.10:ENST00000260952.9:exon5:c.G1536A:p.S512S,ENSG00000286165.1:ENST00000606910.5:exon5:c.G693A:p.S231S	2q32.2	C3N-03007	0.0014	0	8.646e-05	0	0	2.998e-05	0.0022	0.0097	rs377666444	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ASNSD1	143	0	118	22	0.157142857142857	TRUE	NA
ENSG00000221955.10	.	BCM	GRCh38.p13	chr3	125190462	125190462	+	C	C	T	Silent	SNP	ENST00000393469.8	exon2	c.G111A	p.V37V	exonic	ENSG00000221955.10	.	synonymous SNV	ENSG00000221955.10:ENST00000393469.8:exon2:c.G111A:p.V37V	3q21.2	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC12A8	132	0	162	11	0.0635838150289017	TRUE	TRUE
ENSG00000157927.17	.	BCM	GRCh38.p13	chr7	4800204	4800204	+	G	G	A	Silent	SNP	ENST00000399583.4	exon13	c.C2949T	p.P983P	exonic	ENSG00000157927.17	.	synonymous SNV	ENSG00000157927.17:ENST00000399583.4:exon13:c.C2949T:p.P983P	7p22.1	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RADIL	214	0	234	24	0.0930232558139535	TRUE	TRUE
ENSG00000180210.15	.	BCM	GRCh38.p13	chr11	46726076	46726076	+	G	G	A	Silent	SNP	ENST00000311907.10	exon7	c.G777A	p.E259E	exonic	ENSG00000180210.15	.	synonymous SNV	ENSG00000180210.15:ENST00000311907.10:exon7:c.G777A:p.E259E	11p11.2	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	F2	310	1	312	27	0.079646017699115	TRUE	TRUE
ENSG00000172377.2	.	BCM	GRCh38.p13	chr11	58119202	58119202	+	G	G	T	Silent	SNP	ENST00000641439.1	exon3	c.C243A	p.I81I	exonic	ENSG00000172377.2	.	synonymous SNV	ENSG00000172377.2:ENST00000641439.1:exon3:c.C243A:p.I81I	11q12.1	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR9I1	130	0	109	11	0.0916666666666667	TRUE	TRUE
ENSG00000198046.12	.	BCM	GRCh38.p13	chr19	56441711	56441711	+	T	T	C	Silent	SNP	ENST00000504904.8	exon7	c.A1284G	p.A428A	exonic	ENSG00000198046.12	.	synonymous SNV	ENSG00000198046.12:ENST00000504904.8:exon7:c.A1284G:p.A428A	19q13.43	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF667	142	0	149	8	0.0509554140127389	TRUE	NA
ENSG00000088888.18	.	BCM	GRCh38.p13	chr20	3865817	3865817	+	G	G	A	Silent	SNP	ENST00000428216.4	exon7	c.G1293A	p.P431P	exonic	ENSG00000088888.18	.	synonymous SNV	ENSG00000088888.18:ENST00000428216.4:exon7:c.G1293A:p.P431P	20p13	C3N-03007	5.827e-05	0	0	0	0	4.561e-05	0	0.0002	rs546826199	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAVS	385	0	229	22	0.0876494023904383	TRUE	NA
ENSG00000131069.20	.	BCM	GRCh38.p13	chr20	34920667	34920667	+	C	C	T	Silent	SNP	ENST00000360596.7	exon9	c.C1101T	p.Y367Y	exonic	ENSG00000131069.20	.	synonymous SNV	ENSG00000131069.20:ENST00000360596.7:exon9:c.C1101T:p.Y367Y	20q11.22	C3N-03007	1.663e-05	0	0	0.0002	0	0	0	0	rs747790024	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53627601;OCCURENCE=1(large_intestine)	ACSS2	89	0	60	12	0.166666666666667	TRUE	TRUE
ENSG00000159259.8	.	BCM	GRCh38.p13	chr21	36411563	36411563	+	C	C	T	Silent	SNP	ENST00000314103.6	exon11	c.C1020T	p.Y340Y	exonic	ENSG00000159259.8	.	synonymous SNV	ENSG00000159259.8:ENST00000314103.6:exon11:c.C1020T:p.Y340Y	21q22.13	C3N-03007	8.237e-06	0	0	0	0	1.498e-05	0	0	rs370336150	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHAF1B	206	0	139	13	0.0855263157894737	TRUE	NA
ENSG00000179698.14	.	BCM	GRCh38.p13	chr8	144111288	144111288	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000179698.14	.	.	.	8q24.3	C3N-03007	.	.	.	.	.	.	.	.	rs544209807	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WDR97	451	0	414	25	0.0569476082004556	TRUE	NA
ENSG00000166575.17	.	BCM	GRCh38.p13	chr11	87326357	87326357	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000166575.17	ENST00000305494.6:c.*5024C>T	.	.	11q14.2	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM135	344	0	270	17	0.0592334494773519	TRUE	NA
ENSG00000166446.15	.	BCM	GRCh38.p13	chr16	80639683	80639683	+	A	A	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000166446.15	.	.	.	16q23.2	C3N-03007	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDYL2	200	0	180	11	0.0575916230366492	TRUE	NA
ENSG00000130508.11	.	BCM	GRCh38.p13	chr2	1648987	1648987	+	G	G	T	Missense_Mutation	SNP	ENST00000252804.9	exon17	c.C2793A	p.S931R	exonic	ENSG00000130508.11	.	nonsynonymous SNV	ENSG00000130508.11:ENST00000252804.9:exon17:c.C2793A:p.S931R	2p25.3	C3N-03665	.	.	.	.	.	.	.	.	.	9.20	D	T	P	P	D	D	M	T	D	0.654	T	T	D	0.492	0.620	0.767	0.536	T	T	T	T	D	T	3.039	23.500	0.998	D	D	0.417	4.450	0.384	4.245	1.000	0.707	0.574	0.725	0.714	.	5.660	3.800	2.008	1.121	0.676	1.000	1.000	0.963	804	Peroxidasin,_peroxidase_domain	.	.	.	PXDN	140	1	171	18	0.0952380952380952	TRUE	TRUE
ENSG00000115361.8	.	BCM	GRCh38.p13	chr2	210192859	210192859	+	C	C	T	Missense_Mutation	SNP	ENST00000233710.4	exon10	c.G1144A	p.D382N	exonic	ENSG00000115361.8	.	nonsynonymous SNV	ENSG00000115361.8:ENST00000233710.4:exon10:c.G1144A:p.D382N	2q34	C3N-03665	1.654e-05	0	0	0	0	0	0	0.0001	rs774103658	10.20	D	T	P	B	N	N	L	D	N	0.324	D	D	D	0.370	0.617	0.976	0.325	T	D	T	T	D	D	3.095	23.600	0.998	D	D	0.091	2.851	0.212	3.240	0.036	0.554	0.547	0.618	0.613	.	6.030	4.200	2.963	1.026	0.599	1.000	0.996	0.973	709	Acyl-CoA_dehydrogenase/oxidase_C-terminal	.	.	.	ACADL	335	0	510	60	0.105263157894737	TRUE	NA
ENSG00000115414.20	.	BCM	GRCh38.p13	chr2	215431881	215431881	+	A	A	C	Missense_Mutation	SNP	ENST00000354785.10	exon4	c.T499G	p.C167G	exonic	ENSG00000115414.20	.	nonsynonymous SNV	ENSG00000115414.20:ENST00000354785.10:exon4:c.T499G:p.C167G	2q35	C3N-03665	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.969	D	D	D	0.966	0.828	0.989	1.022	D	D	D	D	D	D	4.859	33	0.987	D	D	0.790	8.590	0.800	10.114	1.000	0.706	0.588	0.710	0.658	.	5.780	5.780	8.867	1.312	0.691	1.000	1.000	0.999	744	Fibronectin,_type_I	.	.	.	FN1	452	3	550	76	0.121405750798722	TRUE	TRUE
ENSG00000121871.4	.	BCM	GRCh38.p13	chr3	165190188	165190188	+	C	C	A	Nonsense_Mutation	SNP	ENST00000475390.2	exon2	c.G643T	p.G215X	exonic	ENSG00000121871.4	.	stopgain	ENSG00000121871.4:ENST00000475390.2:exon2:c.G643T:p.G215X	3q26.1	C3N-03665	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.532	.	.	.	.	.	.	.	.	.	D	D	.	.	6.568	36	0.993	D	N	1.215	25.109	1.086	25.550	1.000	0.554	0.590	0.602	0.564	.	5.860	5.860	7.905	1.026	0.599	1.000	0.998	0.996	902	.	.	.	.	SLITRK3	243	0	339	60	0.150375939849624	TRUE	TRUE
ENSG00000022355.18	.	BCM	GRCh38.p13	chr5	161854215	161854215	+	G	G	T	Missense_Mutation	SNP	ENST00000393943.10	exon3	c.G132T	p.R44S	exonic	ENSG00000022355.18	.	nonsynonymous SNV	ENSG00000022355.18:ENST00000393943.10:exon3:c.G132T:p.R44S	5q34	C3N-03665	.	.	.	.	.	.	.	.	.	13.20	D	D	P	P	D	D	L	T	D	0.595	T	T	D	0.588	0.630	0.917	1.418	T	D	D	D	D	D	3.178	23.800	0.997	D	D	0.138	3.038	0.139	2.899	0.003	0.706	0.574	0.710	0.564	.	5.510	2.360	0.960	-0.103	0.618	1.000	0.998	0.997	963	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	.	GABRA1	277	0	353	41	0.104060913705584	TRUE	TRUE
ENSG00000087116.16	.	BCM	GRCh38.p13	chr5	179114148	179114148	+	A	A	T	Missense_Mutation	SNP	ENST00000251582.12	exon22	c.T3355A	p.F1119I	exonic	ENSG00000087116.16	.	nonsynonymous SNV	ENSG00000087116.16:ENST00000251582.12:exon22:c.T3355A:p.F1119I	5q35.3	C3N-03665	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	L	T	N	0.127	T	T	T	0.047	0.377	0.319	0.577	T	T	T	T	T	.	1.875	18.300	0.935	D	N	-0.497	1.183	-0.344	1.476	0.792	0.615	0.574	0.659	0.564	.	5.020	4.050	0.675	0.094	0.756	0.988	0.695	0.587	740	.	.	.	.	ADAMTS2	182	0	212	39	0.155378486055777	TRUE	TRUE
ENSG00000164818.16	.	BCM	GRCh38.p13	chr7	785546	785546	+	C	C	T	Missense_Mutation	SNP	ENST00000297440.11	exon13	c.C2461T	p.P821S	exonic	ENSG00000164818.16	.	nonsynonymous SNV	ENSG00000164818.16:ENST00000297440.11:exon13:c.C2461T:p.P821S	7p22.3	C3N-03665	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	.	T	D	0.563	D	T	D	0.566	0.748	0.329	0.683	T	T	D	D	D	D	3.348	24.300	0.999	D	N	0.549	5.440	0.441	4.663	1.000	0.732	0.744	0.725	0.714	.	4.840	4.840	4.674	1.000	0.599	0.996	0.198	0.147	917	.	.	.	ID=COSV99860295;OCCURENCE=1(skin)	DNAAF5	301	0	375	53	0.123831775700935	TRUE	TRUE
ENSG00000157657.14	.	BCM	GRCh38.p13	chr9	114049070	114049070	+	G	G	A	Missense_Mutation	SNP	ENST00000374126.9	exon15	c.G1768A	p.D590N	exonic	ENSG00000157657.14	.	nonsynonymous SNV	ENSG00000157657.14:ENST00000374126.9:exon15:c.G1768A:p.D590N	9q32	C3N-03665	.	.	.	.	.	.	.	.	.	10.20	D	D	D	B	D	D	N	T	N	0.443	T	T	D	0.149	0.185	0.180	0.891	T	T	T	T	D	D	2.810	23.000	0.998	D	D	0.430	4.534	0.461	4.819	1.000	0.707	0.610	0.725	0.714	.	5.140	5.140	9.232	1.176	0.676	1.000	0.643	0.754	772	.	.	.	.	ZNF618	338	0	404	60	0.129310344827586	TRUE	NA
ENSG00000148498.16	.	BCM	GRCh38.p13	chr10	34372521	34372521	+	G	G	A	Nonsense_Mutation	SNP	ENST00000374789.8	exon12	c.C1684T	p.Q562X	exonic	ENSG00000148498.16	.	stopgain	ENSG00000148498.16:ENST00000374789.8:exon12:c.C1684T:p.Q562X	10p11.21	C3N-03665	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.956	.	.	.	.	.	.	.	.	.	D	D	.	.	8.885	46	0.998	D	N	0.989	13.567	0.887	13.221	1.000	0.706	0.588	0.710	0.613	.	5.830	5.830	7.222	1.155	0.671	1.000	1.000	1.000	872	.	.	.	.	PARD3	200	0	269	28	0.0942760942760943	TRUE	TRUE
ENSG00000279395.3	.	BCM	GRCh38.p13	chr11	55811495	55811495	+	C	C	A	Missense_Mutation	SNP	ENST00000625203.2	exon1	c.C29A	p.A10D	exonic	ENSG00000279395.3	.	nonsynonymous SNV	ENSG00000279395.3:ENST00000625203.2:exon1:c.C29A:p.A10D	11q12.1	C3N-03665	.	.	.	.	.	.	.	.	.	0.16	.	.	B	B	N	N	N	.	.	.	T	T	T	0.012	0.470	.	.	T	T	T	T	T	T	1.156	13.280	0.961	N	N	-0.847	0.589	-0.899	0.622	0.000	0.487	0.574	0.574	0.564	.	4.320	2.330	-0.546	0.757	0.416	0.000	0.023	0.021	155	.	.	.	.	OR5L1	96	0	117	22	0.158273381294964	NA	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-03665	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	318	0	363	67	0.155813953488372	TRUE	TRUE
ENSG00000181234.9	.	BCM	GRCh38.p13	chr12	128669438	128669438	+	G	G	A	Missense_Mutation	SNP	ENST00000435159.2	exon5	c.G1327A	p.A443T	exonic	ENSG00000181234.9	.	nonsynonymous SNV	ENSG00000181234.9:ENST00000435159.2:exon5:c.G1327A:p.A443T	12q24.32	C3N-03665	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.936	T	T	T	0.525	0.774	0.391	0.484	T	T	D	D	D	D	3.849	26.100	0.999	D	D	0.698	7.086	0.566	5.821	1.000	0.554	0.574	0.602	0.613	.	5.010	5.010	9.018	1.176	0.676	1.000	0.954	0.265	994	Transmembrane_protein_family_132,_middle_domain	.	.	ID=COSV59412833;OCCURENCE=1(large_intestine),1(soft_tissue)	TMEM132C	141	0	189	31	0.140909090909091	TRUE	TRUE
ENSG00000182652.3	.	BCM	GRCh38.p13	chr14	19747821	19747821	+	C	C	T	Missense_Mutation	SNP	ENST00000331723.1	exon1	c.C394T	p.R132C	exonic	ENSG00000182652.3	.	nonsynonymous SNV	ENSG00000182652.3:ENST00000331723.1:exon1:c.C394T:p.R132C	14q11.2	C3N-03665	5.78e-05	0	0	0	0	0.0001	0	0	rs368729783	5.20	D	D	D	P	U	N	M	T	D	0.187	T	T	T	0.093	.	0.373	.	T	T	T	T	T	T	2.629	22.700	0.982	N	N	-0.085	2.222	-0.217	1.745	0.000	0.487	0.574	0.574	0.564	.	4.360	3.470	0.462	0.120	0.533	0.001	0.705	0.094	994	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV59178530;OCCURENCE=1(endometrium)	OR4Q3	354	0	453	42	0.0848484848484849	NA	TRUE
ENSG00000255346.10	.	BCM	GRCh38.p13	chr15	69031785	69031785	+	C	C	T	Missense_Mutation	SNP	ENST00000388866.8	exon4	c.C593T	p.P198L	exonic	ENSG00000255346.10	.	nonsynonymous SNV	ENSG00000255346.10:ENST00000388866.8:exon4:c.C593T:p.P198L	15q23	C3N-03665	.	.	.	.	.	.	.	.	.	10.20	T	T	D	D	U	D	M	T	D	0.715	T	T	D	0.316	0.358	0.875	0.807	T	T	T	T	D	D	3.609	25.100	0.995	D	D	0.436	4.574	0.351	4.025	1.000	0.598	0.596	0.378	0.604	.	3.330	3.330	6.334	0.762	0.531	1.000	0.460	0.581	952	EF-hand_domain	.	.	.	NOX5	168	0	166	15	0.0828729281767956	TRUE	TRUE
ENSG00000168961.17	.	BCM	GRCh38.p13	chr17	27647347	27647347	+	G	G	A	Missense_Mutation	SNP	ENST00000395473.7	exon10	c.G836A	p.R279H	exonic	ENSG00000168961.17	.	nonsynonymous SNV	ENSG00000168961.17:ENST00000395473.7:exon10:c.G836A:p.R279H	17q11.2	C3N-03665	0.0001	0	0.0007	0.0001	0	7.497e-05	0	0.0001	rs149003631	11.20	D	D	D	P	D	D	M	T	D	0.731	T	T	D	0.338	.	0.658	1.331	T	T	T	T	T	D	3.661	25.300	0.999	D	D	0.696	7.065	0.553	5.686	0.908	0.707	0.702	0.659	0.714	.	4.360	3.380	4.257	1.175	0.614	1.000	0.944	0.952	256	Galectin,_carbohydrate_recognition_domain	.	.	ID=COSV56350050;OCCURENCE=1(central_nervous_system)	LGALS9	669	2	759	233	0.234879032258065	NA	TRUE
ENSG00000108582.12	.	BCM	GRCh38.p13	chr17	30379218	30379218	+	G	G	T	Missense_Mutation	SNP	ENST00000225719.9	exon1	c.G238T	p.A80S	exonic	ENSG00000108582.12	.	nonsynonymous SNV	ENSG00000108582.12:ENST00000225719.9:exon1:c.G238T:p.A80S	17q11.2	C3N-03665	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	N	T	N	0.252	T	T	D	0.071	0.725	0.168	1.287	D	T	T	T	T	T	1.640	16.630	0.986	D	N	-0.075	2.255	0.042	2.510	1.000	0.524	0.219	0.231	0.658	.	4.220	4.220	0.474	1.046	0.577	0.003	0.989	0.949	620	Carboxypeptidase_D,__carboxypeptidase-like_domain_1;Peptidase_M14,_carboxypeptidase_A	.	.	.	CPD	360	0	521	75	0.125838926174497	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51065549	51065549	+	G	G	A	Missense_Mutation	SNP	ENST00000342988.8	exon9	c.G1082A	p.R361H	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon9:c.G1082A:p.R361H	18q21.2	C3N-03665	.	.	.	.	.	.	.	.	rs377767347	20.20	D	D	D	D	D	D	M	D	D	0.870	D	D	D	0.955	0.987	0.998	3.229	D	D	D	D	D	D	4.374	31	0.999	D	D	0.941	12.166	0.912	14.263	1.000	0.707	0.725	0.725	0.714	.	5.860	5.860	7.959	1.176	0.676	1.000	1.000	0.999	904	SMAD_domain,_Dwarfin-type	.	.	ID=COSV61684056;OCCURENCE=3(breast),1(liver),1(peritoneum),5(oesophagus),5(cervix),104(large_intestine),6(biliary_tract),5(stomach),3(urinary_tract),18(pancreas),1(skin),8(lung),1(thyroid),3(upper_aerodigestive_tract),3(small_intestine),2(endometrium)	SMAD4	174	0	182	33	0.153488372093023	TRUE	TRUE
ENSG00000064687.13	.	BCM	GRCh38.p13	chr19	1047168	1047168	+	C	C	G	Missense_Mutation	SNP	ENST00000263094.11	exon15	c.C1857G	p.I619M	exonic	ENSG00000064687.13	.	nonsynonymous SNV	ENSG00000064687.13:ENST00000263094.11:exon15:c.C1857G:p.I619M	19p13.3	C3N-03665	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	.	N	M	D	N	0.514	T	D	D	0.529	0.493	0.755	0.532	T	D	D	T	D	D	2.854	23.100	0.994	D	N	0.316	3.861	0.161	3.000	0.081	0.675	0.654	0.693	0.568	.	5.210	0.058	-0.070	0.882	0.522	0.305	0.993	0.936	988	.	.	.	.	ABCA7	287	0	371	54	0.127058823529412	TRUE	TRUE
ENSG00000160161.9	.	BCM	GRCh38.p13	chr19	19545435	19545435	+	C	C	T	Missense_Mutation	SNP	ENST00000291495.5	exon8	c.C2890T	p.R964C	exonic	ENSG00000160161.9	.	nonsynonymous SNV	ENSG00000160161.9:ENST00000291495.5:exon8:c.C2890T:p.R964C	19p13.11	C3N-03665	.	.	.	.	.	.	.	.	.	7.20	D	D	D	P	N	N	L	T	D	0.503	T	T	D	0.120	0.305	0.469	0.965	T	T	T	T	D	D	2.998	23.400	0.997	N	N	-0.139	2.054	-0.275	1.617	0.372	0.718	0.547	0.571	0.613	.	5.790	4.690	1.461	-0.005	0.524	0.001	0.005	0.425	432	.	.	.	ID=COSV52274963;OCCURENCE=1(large_intestine)	CILP2	200	1	256	29	0.101754385964912	TRUE	TRUE
ENSG00000160007.19	.	BCM	GRCh38.p13	chr19	46919943	46919943	+	T	T	C	Missense_Mutation	SNP	ENST00000672722.1	exon2	c.T1268C	p.L423P	exonic	ENSG00000160007.19	.	nonsynonymous SNV	ENSG00000160007.19:ENST00000672722.1:exon2:c.T1268C:p.L423P	19q13.32	C3N-03665	.	.	.	.	.	.	.	.	.	15.18	D	D	.	.	D	D	M	T	D	0.955	T	T	D	0.519	0.425	0.805	2.087	D	D	D	D	D	D	4.093	27.700	0.998	D	D	0.873	10.368	0.857	12.018	1.000	0.707	0.725	0.725	0.714	.	6.030	6.030	8.017	1.138	0.665	1.000	0.999	0.978	884	.	.	.	.	ARHGAP35	328	0	384	53	0.121281464530892	TRUE	TRUE
ENSG00000198131.14	.	BCM	GRCh38.p13	chr19	58261325	58261325	+	A	A	C	Missense_Mutation	SNP	ENST00000269829.5	exon4	c.A719C	p.N240T	exonic	ENSG00000198131.14	.	nonsynonymous SNV	ENSG00000198131.14:ENST00000269829.5:exon4:c.A719C:p.N240T	19q13.43	C3N-03665	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.146	T	T	T	0.012	0.292	0.179	0.020	T	T	T	T	T	T	0.545	6.967	0.278	N	N	-1.434	0.104	-1.470	0.120	0.002	0.672	0.702	0.576	0.711	.	3.050	-0.392	0.433	-1.519	-0.634	0.003	0.000	0.001	964	.	.	.	.	ZNF544	176	0	183	34	0.15668202764977	TRUE	TRUE
ENSG00000101188.5	.	BCM	GRCh38.p13	chr20	62760061	62760061	+	G	G	A	Missense_Mutation	SNP	ENST00000370501.4	exon4	c.G1051A	p.A351T	exonic	ENSG00000101188.5	.	nonsynonymous SNV	ENSG00000101188.5:ENST00000370501.4:exon4:c.G1051A:p.A351T	20q13.33	C3N-03665	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.047	T	T	T	0.079	.	0.465	0.295	T	T	T	T	T	T	0.333	4.674	0.374	D	N	-0.992	0.413	-0.922	0.591	0.074	0.624	0.590	0.576	0.580	.	4.980	1.970	2.544	1.176	0.676	0.426	0.152	0.009	862	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV65137923;OCCURENCE=1(stomach)	NTSR1	246	0	252	37	0.1280276816609	TRUE	TRUE
ENSG00000143149.12	.	BCM	GRCh38.p13	chr1	165682979	165682979	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000143149.12	ENST00000354775.4:exon3:c.457+2T>C	.	.	1q24.1	C3N-03665	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.655	32	0.994	D	.	1.054	15.719	0.869	12.506	0.933	0.359	0.340	0.175	0.221	0.749	4.750	4.750	9.085	1.312	0.756	1.000	0.732	0.871	900	.	.	.	.	ALDH9A1	99	0	141	23	0.140243902439024	TRUE	TRUE
ENSG00000115464.15	.	BCM	GRCh38.p13	chr2	61266168	61266168	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000115464.15	ENST00000398571.7:exon42:c.5434-1G>T	.	.	2p15	C3N-03665	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.405	34	0.994	D	.	1.126	18.705	0.975	17.383	1.000	0.295	0.304	0.138	0.118	0.979	5.440	5.440	6.670	1.026	0.599	1.000	0.981	0.800	220	.	.	.	.	USP34	38	0	65	8	0.10958904109589	TRUE	TRUE
ENSG00000102893.16	.	BCM	GRCh38.p13	chr16	47696489	47696489	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000102893.16	ENST00000323584.10:exon29:c.3003+1G>A	.	.	16q12.1	C3N-03665	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.130	33	0.989	D	.	0.979	13.264	0.768	9.232	1.000	0.295	0.304	0.084	0.079	0.903	4.980	4.020	9.874	1.176	0.676	1.000	0.220	0.090	166	.	.	.	.	PHKB	301	0	357	34	0.0869565217391304	TRUE	TRUE
ENSG00000130508.11	.	BCM	GRCh38.p13	chr2	1649464	1649464	+	C	C	T	Silent	SNP	ENST00000252804.9	exon17	c.G2316A	p.E772E	exonic	ENSG00000130508.11	.	synonymous SNV	ENSG00000130508.11:ENST00000252804.9:exon17:c.G2316A:p.E772E	2p25.3	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PXDN	677	0	720	124	0.146919431279621	TRUE	TRUE
ENSG00000011566.15	.	BCM	GRCh38.p13	chr2	39286951	39286951	+	G	G	A	Silent	SNP	ENST00000263881.8	exon21	c.C1488T	p.S496S	exonic	ENSG00000011566.15	.	synonymous SNV	ENSG00000011566.15:ENST00000263881.8:exon21:c.C1488T:p.S496S	2p22.1	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP4K3	114	0	156	25	0.138121546961326	TRUE	TRUE
ENSG00000185008.17	.	BCM	GRCh38.p13	chr3	77644843	77644843	+	C	C	T	Silent	SNP	ENST00000461745.5	exon25	c.C4074T	p.S1358S	exonic	ENSG00000185008.17	.	synonymous SNV	ENSG00000185008.17:ENST00000461745.5:exon25:c.C4074T:p.S1358S	3p12.3	C3N-03665	3.313e-05	0	0	0	0	0	0	0.0002	rs771357490	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ROBO2	321	0	310	45	0.126760563380282	TRUE	NA
ENSG00000084093.18	.	BCM	GRCh38.p13	chr4	56931450	56931450	+	A	A	T	Silent	SNP	ENST00000309042.12	exon4	c.A2592T	p.S864S	exonic	ENSG00000084093.18	.	synonymous SNV	ENSG00000084093.18:ENST00000309042.12:exon4:c.A2592T:p.S864S	4q12	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	REST	248	0	306	54	0.15	TRUE	TRUE
ENSG00000218336.9	.	BCM	GRCh38.p13	chr4	182688269	182688269	+	C	C	T	Silent	SNP	ENST00000511685.6	exon12	c.C2139T	p.H713H	exonic	ENSG00000218336.9	.	synonymous SNV	ENSG00000218336.9:ENST00000511685.6:exon12:c.C2139T:p.H713H	4q35.1	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TENM3	224	0	288	31	0.0971786833855799	TRUE	TRUE
ENSG00000113088.6	.	BCM	GRCh38.p13	chr5	55031564	55031564	+	C	C	T	Silent	SNP	ENST00000231009.3	exon4	c.C564T	p.N188N	exonic	ENSG00000113088.6	.	synonymous SNV	ENSG00000113088.6:ENST00000231009.3:exon4:c.C564T:p.N188N	5q11.2	C3N-03665	0.0083	0.0006	8.645e-05	0.0795	0.0048	0.0010	0.0088	0.0125	rs78739734	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50245360;OCCURENCE=1(stomach),2(haematopoietic_and_lymphoid_tissue)	GZMK	255	0	279	35	0.111464968152866	TRUE	TRUE
ENSG00000145779.8	.	BCM	GRCh38.p13	chr5	119392925	119392925	+	T	T	C	Silent	SNP	ENST00000504771.3	exon2	c.T141C	p.S47S	exonic	ENSG00000145779.8	.	synonymous SNV	ENSG00000145779.8:ENST00000504771.3:exon2:c.T141C:p.S47S	5q23.1	C3N-03665	1.601e-05	0	0	0	0	0	0	9.814e-05	rs755004248	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TNFAIP8	351	1	441	68	0.133595284872299	TRUE	NA
ENSG00000253767.2	.	BCM	GRCh38.p13	chr5	141393248	141393248	+	C	C	T	Silent	SNP	ENST00000398604.2	exon1	c.C435T	p.I145I	exonic	ENSG00000253767.2	.	synonymous SNV	ENSG00000253767.2:ENST00000398604.2:exon1:c.C435T:p.I145I	5q31.3	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53921889;OCCURENCE=3(skin),2(endometrium)	PCDHGA8	231	0	285	45	0.136363636363636	TRUE	TRUE
ENSG00000177409.12	.	BCM	GRCh38.p13	chr7	93131238	93131238	+	T	T	C	Silent	SNP	ENST00000318238.9	exon5	c.A4734G	p.A1578A	exonic	ENSG00000177409.12	.	synonymous SNV	ENSG00000177409.12:ENST00000318238.9:exon5:c.A4734G:p.A1578A	7q21.2	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SAMD9L	44	0	55	8	0.126984126984127	TRUE	TRUE
ENSG00000106123.12	.	BCM	GRCh38.p13	chr7	142864160	142864160	+	C	C	T	Silent	SNP	ENST00000652003.1	exon7	c.C360T	p.S120S	exonic	ENSG00000106123.12	.	synonymous SNV	ENSG00000106123.12:ENST00000652003.1:exon7:c.C360T:p.S120S	7q34	C3N-03665	7.538e-05	0.0004	0	0.0005	0	0	0	6.058e-05	rs533330481	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67419655;OCCURENCE=1(large_intestine)	EPHB6	659	0	880	106	0.107505070993915	TRUE	NA
ENSG00000205442.12	.	BCM	GRCh38.p13	chr9	24545225	24545225	+	A	A	G	Silent	SNP	ENST00000543880.6	exon2	c.T288C	p.N96N	exonic	ENSG00000205442.12	.	synonymous SNV	ENSG00000205442.12:ENST00000543880.6:exon2:c.T288C:p.N96N	9p21.3	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IZUMO3	165	0	183	23	0.111650485436893	TRUE	TRUE
ENSG00000171435.14	.	BCM	GRCh38.p13	chr12	117525064	117525064	+	G	G	A	Silent	SNP	ENST00000339824.7	exon14	c.C2007T	p.G669G	exonic	ENSG00000171435.14	.	synonymous SNV	ENSG00000171435.14:ENST00000339824.7:exon14:c.C2007T:p.G669G	12q24.22	C3N-03665	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56678389;OCCURENCE=1(stomach)	KSR2	153	0	154	30	0.16304347826087	TRUE	TRUE
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65499071	65499071	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3N-03665	6.213e-05	0.0001	0.0002	0	0	6.518e-05	0	0	rs540960944	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	155	0	182	22	0.107843137254902	TRUE	NA
ENSG00000205754.12	.	BCM	GRCh38.p13	chr12	21052115	21052115	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000205754.12	.	.	.	12p12.2	C3N-03665	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	N	M	T	D	0.240	T	T	T	0.090	0.326	0.061	0.006	.	T	T	T	T	T	1.142	13.160	0.820	N	N	-0.937	0.475	-0.989	0.502	0.000	0.487	0.574	0.574	0.564	.	3.090	2.150	0.556	0.986	0.507	0.000	0.021	0.064	923	Major_facilitator_superfamily_domain	.	.	.	SLCO1B7	153	0	179	26	0.126829268292683	TRUE	NA
ENSG00000265690.7	.	BCM	GRCh38.p13	chr16	67164515	67164515	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000265690.7	ENST00000580114.5:c.*233G>A	.	.	16q22.1	C3N-03665	.	.	.	.	.	.	.	.	.	2.12	D	.	.	.	.	D	.	.	N	.	T	T	.	0.126	0.138	0.314	.	.	T	T	T	T	T	0.767	9.075	0.855	N	N	-0.242	1.763	-0.351	1.462	1.000	0.658	0.707	0.608	0.621	.	3.660	3.660	0.156	0.041	-0.123	0.000	0.001	0.053	46	.	.	.	.	AC074143.1	89	0	104	14	0.11864406779661	TRUE	TRUE
ENSG00000074964.17	.	BCM	GRCh38.p13	chr1	17697189	17697189	+	C	C	T	Missense_Mutation	SNP	ENST00000361221.8	exon29	c.C3649T	p.P1217S	exonic	ENSG00000074964.17	.	nonsynonymous SNV	ENSG00000074964.17:ENST00000361221.8:exon29:c.C3649T:p.P1217S	1p36.13	C3L-01598	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.605	T	T	D	0.396	0.446	0.758	0.952	T	T	D	D	D	D	3.817	25.900	0.999	D	D	0.793	8.638	0.746	8.710	1.000	0.632	0.610	0.780	0.568	.	4.890	4.890	7.231	1.022	0.596	1.000	0.990	0.976	873	.	.	.	.	ARHGEF10L	146	0	538	32	0.056140350877193	TRUE	TRUE
ENSG00000122482.21	.	BCM	GRCh38.p13	chr1	90939345	90939345	+	T	T	C	Missense_Mutation	SNP	ENST00000337393.10	exon3	c.A2009G	p.Q670R	exonic	ENSG00000122482.21	.	nonsynonymous SNV	ENSG00000122482.21:ENST00000337393.10:exon3:c.A2009G:p.Q670R	1p22.2	C3L-01598	.	.	.	.	.	.	.	.	.	6.20	D	T	P	B	D	D	L	T	N	0.505	T	T	D	0.165	0.231	0.368	0.646	T	T	T	T	D	T	2.871	23.200	0.991	D	N	0.253	3.548	0.351	4.028	0.999	0.707	0.725	0.702	0.714	.	6.020	4.840	2.226	1.138	0.665	1.000	0.996	0.995	908	.	.	.	.	ZNF644	634	0	1007	81	0.0744485294117647	TRUE	TRUE
ENSG00000116299.17	.	BCM	GRCh38.p13	chr1	109164616	109164616	+	C	C	T	Missense_Mutation	SNP	ENST00000369939.8	exon3	c.C392T	p.P131L	exonic	ENSG00000116299.17	.	nonsynonymous SNV	ENSG00000116299.17:ENST00000369939.8:exon3:c.C392T:p.P131L	1p13.3	C3L-01598	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	N	D	M	T	D	0.964	T	T	D	0.556	0.676	0.730	0.744	T	T	D	D	D	D	3.841	26.000	0.996	D	D	0.868	10.257	0.868	12.444	1.000	0.615	0.492	0.659	0.542	.	5.920	5.920	7.905	1.026	0.599	1.000	1.000	0.997	621	.	.	.	.	KIAA1324	192	0	410	26	0.0596330275229358	TRUE	TRUE
ENSG00000197106.7	.	BCM	GRCh38.p13	chr1	110167078	110167078	+	C	C	T	Missense_Mutation	SNP	ENST00000331565.5	exon2	c.C149T	p.A50V	exonic	ENSG00000197106.7	.	nonsynonymous SNV	ENSG00000197106.7:ENST00000331565.5:exon2:c.C149T:p.A50V	1p13.3	C3L-01598	2.748e-05	0.0001	0	0.0001	0	1.655e-05	0	0	rs770557467	0.20	T	T	B	B	N	N	N	T	N	0.080	T	T	T	0.035	.	0.441	0.551	T	T	T	T	T	T	0.275	3.992	0.963	N	N	-1.029	0.374	-1.017	0.468	0.058	0.497	0.590	0.547	0.542	.	4.550	0.103	0.671	-1.307	-0.182	0.027	0.222	0.403	435	.	.	.	ID=COSV58996157;OCCURENCE=1(breast)	SLC6A17	246	1	589	56	0.0868217054263566	TRUE	TRUE
ENSG00000160688.19	.	BCM	GRCh38.p13	chr1	154983902	154983902	+	G	G	A	Missense_Mutation	SNP	ENST00000292180.8	exon1	c.G208A	p.A70T	exonic	ENSG00000160688.19	.	nonsynonymous SNV	ENSG00000160688.19:ENST00000292180.8:exon1:c.G208A:p.A70T	1q21.3	C3L-01598	.	.	.	.	.	.	.	.	.	6.19	D	D	B	B	N	D	L	.	N	0.269	T	T	T	0.371	0.226	0.599	0.361	T	T	T	T	D	T	2.904	23.200	0.999	D	D	0.012	2.555	0.192	3.144	1.000	0.543	0.522	0.686	0.639	.	5.350	5.350	2.829	1.176	0.676	1.000	0.937	0.798	379	.	.	.	.	FLAD1	91	0	170	13	0.0710382513661202	TRUE	TRUE
ENSG00000116539.13	.	BCM	GRCh38.p13	chr1	155482190	155482190	+	C	C	T	Missense_Mutation	SNP	ENST00000368346.7	exon3	c.G680A	p.C227Y	exonic	ENSG00000116539.13	.	nonsynonymous SNV	ENSG00000116539.13:ENST00000368346.7:exon3:c.G680A:p.C227Y	1q22	C3L-01598	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	N	D	N	0.820	D	D	D	0.467	0.192	0.730	1.062	D	T	D	D	D	D	3.609	25.100	0.996	D	D	0.518	5.181	0.550	5.649	1.000	0.719	0.723	0.609	0.636	.	4.740	4.740	5.984	1.026	0.599	1.000	1.000	0.998	52	.	.	.	.	ASH1L	366	0	527	60	0.10221465076661	TRUE	NA
ENSG00000155816.20	.	BCM	GRCh38.p13	chr1	240123338	240123338	+	C	C	A	Nonsense_Mutation	SNP	ENST00000319653.14	exon2	c.C1775A	p.S592X	exonic	ENSG00000155816.20	.	stopgain	ENSG00000155816.20:ENST00000319653.14:exon2:c.C1775A:p.S592X	1q43	C3L-01598	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.869	.	.	.	.	.	.	.	.	.	D	D	.	.	8.150	41	0.997	D	N	0.812	9.019	0.637	6.723	1.000	0.554	0.574	0.608	0.621	.	5.690	5.690	3.114	0.947	0.599	0.992	0.625	0.133	976	DEP_domain	.	.	.	FMN2	122	0	217	27	0.110655737704918	TRUE	TRUE
ENSG00000115423.19	.	BCM	GRCh38.p13	chr2	84621290	84621290	+	G	G	C	Missense_Mutation	SNP	ENST00000389394.8	exon25	c.G3892C	p.A1298P	exonic	ENSG00000115423.19	.	nonsynonymous SNV	ENSG00000115423.19:ENST00000389394.8:exon25:c.G3892C:p.A1298P	2p11.2	C3L-01598	.	.	.	.	.	.	.	.	.	8.18	T	.	D	P	.	N	M	T	D	0.647	T	T	D	0.378	0.763	0.591	0.248	T	T	D	T	D	T	3.073	23.600	0.997	D	D	0.530	5.278	0.516	5.308	0.001	0.549	0.574	0.598	0.616	.	5.020	4.130	3.061	1.089	0.676	1.000	1.000	0.998	699	Dynein_heavy_chain,_domain-2	.	.	.	DNAH6	323	0	597	58	0.0885496183206107	TRUE	TRUE
ENSG00000196460.14	.	BCM	GRCh38.p13	chr2	101466790	101466790	+	G	G	A	Missense_Mutation	SNP	ENST00000428343.6	exon2	c.C59T	p.A20V	exonic	ENSG00000196460.14	.	nonsynonymous SNV	ENSG00000196460.14:ENST00000428343.6:exon2:c.C59T:p.A20V	2q11.2	C3L-01598	.	.	.	.	.	.	.	.	.	11.17	T	D	D	P	.	N	.	D	N	0.408	D	D	D	0.506	0.255	0.597	0.000	T	.	D	D	D	D	2.696	22.800	0.999	D	N	0.468	4.798	0.412	4.448	1.000	0.495	0.590	0.527	0.751	.	5.200	5.200	3.529	1.176	0.676	1.000	0.441	0.628	881	DNA-binding_RFX-type_winged-helix_domain	.	.	.	RFX8	369	0	646	50	0.0718390804597701	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178739848	178739848	+	A	A	T	Missense_Mutation	SNP	ENST00000591111.5	exon46	c.T12434A	p.V4145D	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon46:c.T12434A:p.V4145D	2q31.2	C3L-01598	.	.	.	.	.	.	.	.	.	4.14	D	.	.	.	.	D	.	T	N	0.298	T	T	D	0.167	0.553	0.544	0.139	T	.	T	T	T	T	1.793	17.680	0.661	N	D	-0.309	1.592	-0.190	1.809	1.000	0.487	0.574	0.574	0.564	.	5.560	5.560	4.505	1.312	0.756	0.564	0.270	0.603	341	.	.	.	.	TTN	543	0	689	44	0.0600272851296044	TRUE	TRUE
ENSG00000155749.12	.	BCM	GRCh38.p13	chr2	201342410	201342410	+	G	G	A	Missense_Mutation	SNP	ENST00000405148.6	exon7	c.C484T	p.R162C	exonic	ENSG00000155749.12	.	nonsynonymous SNV	ENSG00000155749.12:ENST00000405148.6:exon7:c.C484T:p.R162C	2q33.1	C3L-01598	8.248e-06	0	0	0	0	1.5e-05	0	0	rs144590707	9.20	D	D	D	D	N	D	M	T	D	0.355	T	T	T	0.106	.	0.644	0.092	T	T	T	T	D	D	3.733	25.500	0.999	N	N	-0.076	2.253	-0.192	1.806	0.029	0.554	0.574	0.547	0.621	.	4.590	3.690	2.639	0.245	0.676	0.068	0.962	0.705	602	.	.	.	.	FLACC1	247	0	384	30	0.072463768115942	TRUE	NA
ENSG00000168016.14	.	BCM	GRCh38.p13	chr3	36832939	36832939	+	C	C	T	Missense_Mutation	SNP	ENST00000429976.5	exon21	c.G6512A	p.R2171H	exonic	ENSG00000168016.14	.	nonsynonymous SNV	ENSG00000168016.14:ENST00000429976.5:exon21:c.G6512A:p.R2171H	3p22.2	C3L-01598	1.784e-05	0	0	0.0001	0	1.613e-05	0	0	rs370553712	8.20	D	D	D	P	D	N	M	T	N	0.595	T	T	T	0.099	.	0.508	0.763	T	T	T	T	D	D	3.760	25.700	0.999	D	N	0.439	4.595	0.443	4.675	0.911	0.615	0.634	0.659	0.655	.	5.160	5.160	3.128	1.026	0.599	0.982	0.997	0.999	744	.	.	.	ID=COSV57155336;OCCURENCE=1(kidney)	TRANK1	259	0	366	32	0.0804020100502513	TRUE	TRUE
ENSG00000168038.11	.	BCM	GRCh38.p13	chr3	41717744	41717744	+	C	C	A	Missense_Mutation	SNP	ENST00000301831.9	exon23	c.G2439T	p.E813D	exonic	ENSG00000168038.11	.	nonsynonymous SNV	ENSG00000168038.11:ENST00000301831.9:exon23:c.G2439T:p.E813D	3p22.1	C3L-01598	.	.	.	.	.	.	.	.	.	4.20	T	T	D	P	U	N	M	T	N	0.477	T	T	T	0.333	0.243	0.640	0.061	T	T	T	T	D	T	1.929	18.710	0.991	D	N	-0.561	1.059	-0.719	0.872	0.084	0.638	0.588	0.653	0.568	.	5.450	-7.550	0.105	-1.177	-0.780	0.973	0.715	0.978	760	.	.	.	.	ULK4	113	0	215	31	0.126016260162602	TRUE	TRUE
ENSG00000144821.10	.	BCM	GRCh38.p13	chr3	108416880	108416880	+	A	A	G	Missense_Mutation	SNP	ENST00000273353.4	exon30	c.T3940C	p.S1314P	exonic	ENSG00000144821.10	.	nonsynonymous SNV	ENSG00000144821.10:ENST00000273353.4:exon30:c.T3940C:p.S1314P	3q13.13	C3L-01598	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	.	D	M	T	D	0.441	D	D	D	0.385	0.625	0.799	0.505	T	D	T	T	D	D	2.478	22.400	0.990	N	N	-0.284	1.652	-0.548	1.125	0.003	0.487	0.574	0.547	0.564	.	4.500	0.367	0.210	-0.099	-0.208	0.129	0.347	0.585	354	Myosin_tail	.	.	.	MYH15	288	0	460	35	0.0707070707070707	TRUE	TRUE
ENSG00000113790.11	.	BCM	GRCh38.p13	chr3	185229455	185229455	+	G	G	A	Missense_Mutation	SNP	ENST00000231887.8	exon4	c.C440T	p.A147V	exonic	ENSG00000113790.11	.	nonsynonymous SNV	ENSG00000113790.11:ENST00000231887.8:exon4:c.C440T:p.A147V	3q27.2	C3L-01598	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	L	T	N	0.304	T	T	T	0.073	0.585	0.273	0.084	T	T	T	T	D	D	2.335	21.800	0.994	D	N	-0.107	2.153	0.057	2.566	0.602	0.638	0.588	0.653	0.668	.	6.070	4.270	3.844	0.245	0.671	1.000	1.000	0.993	679	.	.	.	.	EHHADH	48	0	95	5	0.05	TRUE	NA
ENSG00000155269.12	.	BCM	GRCh38.p13	chr4	8581038	8581038	+	C	C	T	Missense_Mutation	SNP	ENST00000382487.5	exon1	c.C56T	p.A19V	exonic	ENSG00000155269.12	.	nonsynonymous SNV	ENSG00000155269.12:ENST00000382487.5:exon1:c.C56T:p.A19V	4p16.1	C3L-01598	2.411e-05	0	0	0	0	4.351e-05	0	0	.	6.20	D	D	D	B	U	D	L	T	N	0.251	T	T	T	0.167	0.623	0.475	0.045	T	T	T	T	D	T	2.376	22.000	0.981	D	N	-0.126	2.095	-0.244	1.684	1.000	0.598	0.547	0.504	0.639	.	2.390	2.390	4.831	0.686	0.454	0.998	0.002	0.057	988	.	.	.	ID=COSV66763155;OCCURENCE=2(large_intestine)	GPR78	148	0	298	30	0.0914634146341463	TRUE	TRUE
ENSG00000215612.8	.	BCM	GRCh38.p13	chr4	8867842	8867842	+	C	C	T	Missense_Mutation	SNP	ENST00000400677.5	exon2	c.G898A	p.A300T	exonic	ENSG00000215612.8	.	nonsynonymous SNV	ENSG00000215612.8:ENST00000400677.5:exon2:c.G898A:p.A300T	4p16.1	C3L-01598	.	.	.	.	.	.	.	.	rs1050213588	3.19	T	T	B	B	.	N	N	D	N	0.191	T	T	D	0.135	0.335	0.799	0.893	D	T	T	T	T	T	0.981	11.380	0.992	N	N	-0.969	0.438	-0.936	0.572	0.744	0.598	0.590	0.616	0.639	.	1.700	-0.008	0.126	0.687	0.473	0.002	0.223	0.098	.	.	.	.	.	HMX1	17	0	58	6	0.09375	TRUE	NA
ENSG00000163736.4	.	BCM	GRCh38.p13	chr4	73987956	73987956	+	C	C	T	Missense_Mutation	SNP	ENST00000296028.4	exon1	c.G148A	p.E50K	exonic	ENSG00000163736.4	.	nonsynonymous SNV	ENSG00000163736.4:ENST00000296028.4:exon1:c.G148A:p.E50K	4q13.3	C3L-01598	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.137	T	T	T	0.016	0.348	0.362	0.017	T	T	T	T	T	T	2.268	21.400	0.503	N	N	-1.055	0.348	-1.172	0.307	1.000	0.581	0.563	0.565	0.564	.	2.230	-0.757	-0.421	-0.440	0.469	0.000	0.000	0.020	240	.	.	.	.	PPBP	218	0	371	33	0.0816831683168317	TRUE	NA
ENSG00000152208.13	.	BCM	GRCh38.p13	chr4	93422960	93422960	+	G	G	C	Missense_Mutation	SNP	ENST00000282020.9	exon10	c.G1537C	p.V513L	exonic	ENSG00000152208.13	.	nonsynonymous SNV	ENSG00000152208.13:ENST00000282020.9:exon10:c.G1537C:p.V513L	4q22.2	C3L-01598	.	.	.	.	.	.	.	.	.	8.20	D	T	B	B	D	D	N	T	N	0.238	T	T	T	0.032	0.698	0.355	0.212	D	T	T	T	D	D	3.037	23.500	0.987	D	D	-0.149	2.025	0.047	2.525	0.051	0.693	0.574	0.659	0.564	.	5.550	4.710	4.764	1.176	0.671	1.000	0.997	0.992	935	Ionotropic_glutamate_receptor,_L-glutamate_and_glycine-binding_domain;Ionotropic_glutamate_receptor	.	.	.	GRID2	286	0	409	35	0.0788288288288288	TRUE	TRUE
ENSG00000168594.15	.	BCM	GRCh38.p13	chr4	174977077	174977077	+	G	G	A	Missense_Mutation	SNP	ENST00000359240.7	exon5	c.G1552A	p.E518K	exonic	ENSG00000168594.15	.	nonsynonymous SNV	ENSG00000168594.15:ENST00000359240.7:exon5:c.G1552A:p.E518K	4q34.1	C3L-01598	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	U	N	L	T	N	0.090	T	T	T	0.027	0.585	0.300	0.089	T	T	T	T	T	T	-0.451	0.150	0.712	N	N	-1.884	0.016	-2.002	0.013	0.082	0.487	0.574	0.574	0.564	.	3.480	-6.970	-2.789	-0.968	-0.955	0.000	0.000	0.000	960	ADAM,_cysteine-rich	.	.	ID=COSV63665303;OCCURENCE=1(breast)	ADAM29	203	2	245	17	0.0648854961832061	NA	TRUE
ENSG00000170549.4	.	BCM	GRCh38.p13	chr5	3601006	3601006	+	C	C	T	Missense_Mutation	SNP	ENST00000302006.4	exon4	c.C1409T	p.T470M	exonic	ENSG00000170549.4	.	nonsynonymous SNV	ENSG00000170549.4:ENST00000302006.4:exon4:c.C1409T:p.T470M	5p15.33	C3L-01598	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	U	D	L	T	N	0.486	T	T	D	0.180	0.124	0.920	.	T	T	D	T	D	T	4.242	29.000	0.999	D	D	0.661	6.609	0.638	6.737	1.000	0.726	0.547	0.594	0.639	.	4.770	4.770	6.184	1.026	0.599	1.000	0.990	0.997	982	.	.	.	ID=COSV57358201;OCCURENCE=2(large_intestine),1(upper_aerodigestive_tract)	IRX1	343	1	634	50	0.0730994152046784	TRUE	TRUE
ENSG00000082516.9	.	BCM	GRCh38.p13	chr5	154931536	154931536	+	G	G	A	Missense_Mutation	SNP	ENST00000285873.8	exon5	c.C703T	p.P235S	exonic	ENSG00000082516.9	.	nonsynonymous SNV	ENSG00000082516.9:ENST00000285873.8:exon5:c.C703T:p.P235S	5q33.2	C3L-01598	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.232	T	T	D	0.067	0.479	0.635	0.075	T	T	T	T	T	T	0.363	5.011	0.498	N	N	-0.739	0.749	-0.719	0.873	1.000	0.707	0.654	0.725	0.714	.	5.250	2.220	0.083	0.199	-0.153	0.289	0.360	0.303	875	WD40-repeat-containing_domain	.	.	.	GEMIN5	141	0	207	21	0.0921052631578947	TRUE	TRUE
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	170041074	170041074	+	G	G	A	Missense_Mutation	SNP	ENST00000520908.7	exon37	c.G3685A	p.D1229N	exonic	ENSG00000134516.18	.	nonsynonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon37:c.G3685A:p.D1229N	5q35.1	C3L-01598	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	D	D	L	T	D	0.771	T	T	D	0.347	0.326	0.859	1.391	D	T	T	T	D	D	4.279	29.400	0.999	D	D	0.693	7.018	0.678	7.353	1.000	0.707	0.725	0.567	0.616	.	5.320	5.320	9.962	1.172	0.672	1.000	0.543	0.345	964	DHR-2_domain;Dedicator_of_cytokinesis,_C-terminal	.	.	ID=COSV56959162;OCCURENCE=2(skin),1(endometrium)	DOCK2	289	0	527	34	0.0606060606060606	TRUE	TRUE
ENSG00000079691.18	.	BCM	GRCh38.p13	chr6	25600555	25600555	+	G	G	A	Missense_Mutation	SNP	ENST00000329474.7	exon33	c.G3361A	p.E1121K	exonic	ENSG00000079691.18	.	nonsynonymous SNV	ENSG00000079691.18:ENST00000329474.7:exon33:c.G3361A:p.E1121K	6p22.2	C3L-01598	.	.	.	.	.	.	.	.	.	6.19	D	T	B	B	N	D	.	T	N	0.169	T	T	T	0.092	0.268	0.068	0.385	T	T	T	T	D	D	3.303	24.100	0.998	D	D	-0.090	2.205	-0.046	2.208	1.000	0.706	0.588	0.710	0.564	.	4.690	3.810	8.725	1.176	0.676	1.000	0.510	0.982	617	.	.	.	.	CARMIL1	380	1	531	45	0.078125	TRUE	TRUE
ENSG00000204248.11	.	BCM	GRCh38.p13	chr6	33169880	33169880	+	-	NA	C	Frame_Shift_Ins	NA	ENST00000374708.8	exon48	c.3382dupG	p.E1128Gfs*41	exonic	ENSG00000204248.11	.	frameshift insertion	ENSG00000204248.11:ENST00000374708.8:exon48:c.3382dupG:p.E1128Gfs*41	6p21.32	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL11A2	NA	NA	NA	NA	NA	NA	NA
ENSG00000111880.16	.	BCM	GRCh38.p13	chr6	88844398	88844398	+	C	C	T	Missense_Mutation	SNP	ENST00000369485.9	exon11	c.G1228A	p.V410I	exonic	ENSG00000111880.16	.	nonsynonymous SNV	ENSG00000111880.16:ENST00000369485.9:exon11:c.G1228A:p.V410I	6q15	C3L-01598	1.648e-05	9.625e-05	0	0	0	1.499e-05	0	0	rs772588621	7.20	T	T	B	B	D	D	L	D	N	0.333	T	T	D	0.405	0.571	0.595	0.571	T	T	T	T	T	D	2.165	20.600	0.997	D	D	0.050	2.695	0.251	3.441	1.000	0.707	0.725	0.659	0.564	.	5.700	5.700	6.009	1.026	0.599	1.000	1.000	0.996	797	mRNA_capping_enzyme,_catalytic_domain	.	.	.	RNGTT	256	0	374	31	0.0765432098765432	TRUE	NA
ENSG00000154269.15	.	BCM	GRCh38.p13	chr6	131693509	131693509	+	G	G	A	Missense_Mutation	SNP	ENST00000357639.8	exon15	c.G1297A	p.D433N	exonic	ENSG00000154269.15	.	nonsynonymous SNV	ENSG00000154269.15:ENST00000357639.8:exon15:c.G1297A:p.D433N	6q23.2	C3L-01598	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.190	T	T	T	0.106	0.601	0.465	0.062	T	T	T	T	T	T	1.248	14.000	0.844	N	N	-0.937	0.476	-0.837	0.707	0.059	0.487	0.590	0.492	0.564	.	5.920	3.190	1.396	1.176	0.676	0.065	0.224	0.543	872	.	.	.	.	ENPP3	184	0	233	19	0.0753968253968254	TRUE	NA
ENSG00000078053.17	.	BCM	GRCh38.p13	chr7	38426954	38426954	+	C	C	A	Missense_Mutation	SNP	ENST00000356264.7	exon15	c.G1215T	p.Q405H	exonic	ENSG00000078053.17	.	nonsynonymous SNV	ENSG00000078053.17:ENST00000356264.7:exon15:c.G1215T:p.Q405H	7p14.1	C3L-01598	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	N	D	L	T	N	0.456	T	T	D	0.204	0.124	0.885	0.649	T	T	D	T	D	T	6.606	36	0.997	D	D	0.671	6.731	0.664	7.130	1.000	0.706	0.575	0.710	0.613	.	5.380	5.380	5.480	1.026	0.599	1.000	0.996	0.955	784	.	.	.	.	AMPH	205	0	366	30	0.0757575757575758	TRUE	TRUE
ENSG00000172209.6	.	BCM	GRCh38.p13	chr7	107474893	107474893	+	G	G	A	Missense_Mutation	SNP	ENST00000304402.6	exon3	c.G833A	p.R278K	exonic	ENSG00000172209.6	.	nonsynonymous SNV	ENSG00000172209.6:ENST00000304402.6:exon3:c.G833A:p.R278K	7q22.3	C3L-01598	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	D	D	L	T	N	0.096	T	T	T	0.054	0.396	0.296	0.601	T	T	T	T	T	.	1.880	18.330	0.908	D	N	-0.027	2.418	0.169	3.038	1.000	0.554	0.574	0.547	0.568	.	5.560	5.560	4.210	1.176	0.618	1.000	1.000	0.999	829	GPCR,_rhodopsin-like,_7TM	.	.	.	GPR22	301	0	431	30	0.0650759219088937	TRUE	TRUE
ENSG00000128591.15	.	BCM	GRCh38.p13	chr7	128841257	128841257	+	A	A	C	Missense_Mutation	SNP	ENST00000325888.12	exon12	c.A1901C	p.E634A	exonic	ENSG00000128591.15	.	nonsynonymous SNV	ENSG00000128591.15:ENST00000325888.12:exon12:c.A1901C:p.E634A	7q32.1	C3L-01598	.	.	.	.	.	.	.	.	.	16.20	T	T	P	P	D	D	M	D	D	0.830	D	D	D	0.816	0.522	0.925	0.774	D	D	D	D	D	D	4.051	27.400	0.991	D	D	0.413	4.424	0.470	4.899	1.000	0.707	0.187	0.723	0.714	.	5.200	5.200	9.239	1.312	0.691	1.000	0.976	0.890	621	.	.	.	.	FLNC	282	1	496	45	0.0831792975970425	TRUE	TRUE
ENSG00000257743.8	.	BCM	GRCh38.p13	chr7	142171328	142171328	+	C	C	T	Missense_Mutation	SNP	ENST00000477922.3	exon28	c.C3239T	p.T1080M	exonic	ENSG00000257743.8	.	nonsynonymous SNV	ENSG00000257743.8:ENST00000477922.3:exon28:c.C3239T:p.T1080M	7q34	C3L-01598	0.0003	0	0	0	0	0.0009	0	0.0001	rs778452821	6.11	.	D	.	.	D	.	.	.	.	0.466	T	T	D	0.318	.	0.165	.	.	D	T	T	T	.	3.079	23.600	0.998	D	D	0.156	3.116	0.128	2.850	0.869	0.500	0.574	0.574	0.504	.	4.930	4.930	6.014	1.022	0.596	1.000	0.548	0.172	934	Galactose_mutarotase,_N-terminal_barrel	.	.	.	MGAM2	531	0	771	56	0.0677146311970979	TRUE	NA
ENSG00000165125.21	.	BCM	GRCh38.p13	chr7	142875623	142875623	+	G	G	A	Missense_Mutation	SNP	ENST00000359396.8	exon8	c.C1087T	p.R363W	exonic	ENSG00000165125.21	.	nonsynonymous SNV	ENSG00000165125.21:ENST00000359396.8:exon8:c.C1087T:p.R363W	7q34	C3L-01598	1.651e-05	0.0002	0	0	0	0	0	0	rs375745559	8.17	T	D	.	.	D	N	.	D	N	0.437	T	T	D	0.157	.	0.646	0.806	T	D	T	T	D	D	2.174	20.700	0.995	N	D	-0.578	1.028	-0.806	0.750	0.342	0.497	0.547	0.547	0.542	.	4.710	-2.560	1.602	-0.176	-0.877	0.036	0.930	0.154	705	.	.	.	ID=COSV63894082;OCCURENCE=1(large_intestine)	TRPV6	136	0	274	25	0.0836120401337793	TRUE	TRUE
ENSG00000130226.17	.	BCM	GRCh38.p13	chr7	154892446	154892446	+	C	C	G	Missense_Mutation	SNP	ENST00000377770.8	exon26	c.C2564G	p.T855R	exonic	ENSG00000130226.17	.	nonsynonymous SNV	ENSG00000130226.17:ENST00000377770.8:exon26:c.C2564G:p.T855R	7q36.2	C3L-01598	.	.	.	.	.	.	.	.	.	1.19	D	T	B	B	N	N	L	T	N	0.173	T	T	T	0.075	0.493	0.068	0.501	T	T	T	T	T	.	0.743	8.851	0.837	N	N	-0.693	0.824	-0.704	0.894	0.242	0.646	0.574	0.645	0.613	.	4.660	3.780	2.224	0.122	0.596	0.061	0.001	0.023	958	.	.	.	.	DPP6	185	0	337	29	0.0792349726775956	TRUE	TRUE
ENSG00000170961.7	.	BCM	GRCh38.p13	chr8	121614402	121614402	+	C	C	T	Missense_Mutation	SNP	ENST00000303924.5	exon4	c.G1366A	p.A456T	exonic	ENSG00000170961.7	.	nonsynonymous SNV	ENSG00000170961.7:ENST00000303924.5:exon4:c.G1366A:p.A456T	8q24.13	C3L-01598	.	.	.	.	.	.	.	.	.	7.20	T	T	P	P	D	D	L	T	N	0.441	T	T	T	0.220	0.546	0.068	1.547	D	T	T	T	D	D	3.481	24.600	0.998	D	D	0.524	5.228	0.620	6.483	1.000	0.554	0.574	0.602	0.564	.	6.170	6.170	5.048	1.026	0.594	1.000	0.961	0.997	864	.	.	.	.	HAS2	228	2	356	28	0.0729166666666667	NA	TRUE
ENSG00000160949.17	.	BCM	GRCh38.p13	chr8	144444410	144444410	+	C	C	A	Missense_Mutation	SNP	ENST00000409379.8	exon1	c.G5T	p.S2I	exonic	ENSG00000160949.17	.	nonsynonymous SNV	ENSG00000160949.17:ENST00000409379.8:exon1:c.G5T:p.S2I	8q24.3	C3L-01598	.	.	.	.	.	.	.	.	rs1052374304	2.18	T	D	B	B	.	N	L	T	N	0.080	T	T	D	0.031	.	0.092	0.164	T	T	T	T	T	.	0.737	8.789	0.898	N	N	-1.442	0.101	-1.553	0.089	1.000	0.468	0.484	0.504	0.373	.	4.910	-6.910	-2.318	-0.981	-1.395	0.000	0.003	0.005	940	.	.	.	.	TONSL	16	0	51	6	0.105263157894737	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971158	21971177	+	GCCGTGGAGCAGCAGCAGCT	GCCGTGGAGCAGCAGCAGCT	-	Frame_Shift_Del	DEL	ENST00000304494.9	exon2	c.182_201del	p.E61Gfs*52	exonic	ENSG00000147889.17	.	frameshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.182_201del:p.E61Gfs*52	9p21.3	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	457	0	901	77	0.0787321063394683	NA	TRUE
ENSG00000120054.12	.	BCM	GRCh38.p13	chr10	100042476	100042476	+	G	G	A	Missense_Mutation	SNP	ENST00000370418.8	exon9	c.C1328T	p.A443V	exonic	ENSG00000120054.12	.	nonsynonymous SNV	ENSG00000120054.12:ENST00000370418.8:exon9:c.C1328T:p.A443V	10q24.2	C3L-01598	8.238e-06	0	0	0	0	0	0	6.057e-05	rs758222936	0.20	T	T	B	B	N	N	N	T	N	0.077	T	T	T	0.029	0.186	0.268	0.397	T	T	T	T	T	T	0.452	6.000	0.924	N	N	-0.940	0.472	-0.912	0.603	0.994	0.554	0.492	0.602	0.613	.	4.580	2.720	0.111	1.176	0.674	0.000	0.018	0.016	831	.	.	.	.	CPN1	595	0	1082	92	0.0783645655877342	TRUE	NA
ENSG00000129159.8	.	BCM	GRCh38.p13	chr11	17736018	17736018	+	G	G	A	Missense_Mutation	SNP	ENST00000379472.4	exon1	c.G16A	p.E6K	exonic	ENSG00000129159.8	.	nonsynonymous SNV	ENSG00000129159.8:ENST00000379472.4:exon1:c.G16A:p.E6K	11p15.1	C3L-01598	.	.	.	.	.	.	.	.	.	12.20	T	T	D	B	N	D	L	D	N	0.240	D	D	D	0.434	0.410	0.890	2.298	T	T	D	D	D	D	2.936	23.300	0.995	D	D	0.076	2.793	0.169	3.037	1.000	0.598	0.616	0.378	0.639	.	4.230	4.230	6.814	1.176	0.618	1.000	1.000	0.999	789	.	.	.	.	KCNC1	54	1	87	8	0.0842105263157895	TRUE	TRUE
ENSG00000124942.14	.	BCM	GRCh38.p13	chr11	62520796	62520796	+	C	C	T	Missense_Mutation	SNP	ENST00000378024.9	exon5	c.G13621A	p.V4541I	exonic	ENSG00000124942.14	.	nonsynonymous SNV	ENSG00000124942.14:ENST00000378024.9:exon5:c.G13621A:p.V4541I	11q12.3	C3L-01598	0.0001	0.0003	0	0.0013	0	0	0	6.058e-05	rs202195084	0.19	T	T	B	B	N	N	N	T	N	0.025	T	T	T	0.068	.	0.107	0.024	T	T	T	T	T	T	-2.900	0.001	0.471	N	.	-1.746	0.030	-1.916	0.020	1.000	0.732	0.744	0.659	0.711	.	4.920	-9.840	-3.238	-3.750	-3.118	0.000	0.000	0.000	219	.	.	.	ID=COSV57210711;OCCURENCE=1(oesophagus),1(stomach)	AHNAK	266	2	361	38	0.0952380952380952	NA	TRUE
ENSG00000234560.4	.	BCM	GRCh38.p13	chr11	124030164	124030164	+	C	C	T	Missense_Mutation	SNP	ENST00000431524.1	exon1	c.C542T	p.P181L	exonic	ENSG00000234560.4	.	nonsynonymous SNV	ENSG00000234560.4:ENST00000431524.1:exon1:c.C542T:p.P181L	11q24.2	C3L-01598	8.237e-06	0	0	0	0	1.498e-05	0	0	rs776182491	5.20	T	T	D	D	D	N	L	T	D	0.123	T	T	T	0.079	0.474	0.369	0.286	T	T	T	T	D	T	2.202	20.900	0.996	N	N	-0.092	2.201	-0.297	1.570	0.001	0.487	0.590	0.547	0.564	.	3.040	3.040	0.334	0.937	0.573	0.000	0.016	0.004	773	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV70909383;OCCURENCE=1(stomach)	OR10G8	312	1	697	60	0.0792602377807133	NA	TRUE
ENSG00000166105.16	.	BCM	GRCh38.p13	chr11	134314425	134314425	+	C	C	A	Missense_Mutation	SNP	ENST00000431683.7	exon18	c.C1763A	p.T588N	exonic	ENSG00000166105.16	.	nonsynonymous SNV	ENSG00000166105.16:ENST00000431683.7:exon18:c.C1763A:p.T588N	11q25	C3L-01598	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	D	D	0.717	D	D	D	0.860	0.583	0.677	0.279	T	T	D	D	D	T	3.647	25.200	0.992	D	D	0.888	10.740	0.774	9.399	1.000	0.744	0.627	0.630	0.564	.	4.640	4.640	5.037	1.008	0.599	1.000	0.988	0.983	952	.	.	.	.	GLB1L3	404	0	907	63	0.0649484536082474	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01598	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	356	0	569	106	0.157037037037037	TRUE	TRUE
ENSG00000139626.16	.	BCM	GRCh38.p13	chr12	53192752	53192752	+	C	C	T	Missense_Mutation	SNP	ENST00000267082.10	exon13	c.G1885A	p.G629S	exonic	ENSG00000139626.16	.	nonsynonymous SNV	ENSG00000139626.16:ENST00000267082.10:exon13:c.G1885A:p.G629S	12q13.13	C3L-01598	0.0082	0.0013	0.0266	0	0.0189	0.0026	0.0055	0.0224	rs61754162	12.19	T	T	D	D	D	D	M	D	D	0.375	D	D	.	0.668	.	0.937	0.980	T	D	T	D	T	T	2.632	22.700	0.998	D	N	0.421	4.475	0.330	3.896	1.000	0.672	0.702	0.514	0.646	.	5.130	5.130	2.442	1.023	0.595	0.992	0.133	0.044	735	EGF-like_domain,_extracellular	.	.	ID=COSV57239218;OCCURENCE=1(lung)	ITGB7	264	0	555	49	0.0811258278145695	TRUE	TRUE
ENSG00000139767.10	.	BCM	GRCh38.p13	chr12	119130782	119130782	+	G	G	A	Missense_Mutation	SNP	ENST00000267260.5	exon8	c.G719A	p.R240H	exonic	ENSG00000139767.10	.	nonsynonymous SNV	ENSG00000139767.10:ENST00000267260.5:exon8:c.G719A:p.R240H	12q24.23	C3L-01598	1.746e-05	0	0	0.0001	0	1.573e-05	0	0	rs780069693	0.20	T	T	B	B	N	N	N	T	N	0.049	T	T	T	0.029	0.245	0.014	0.190	T	T	T	T	T	T	-0.517	0.109	0.619	N	N	-1.716	0.034	-1.726	0.046	0.089	0.554	0.574	0.602	0.564	.	5.070	-6.470	0.052	-1.093	-0.815	0.012	0.002	0.009	950	.	.	.	ID=COSV57410239;OCCURENCE=1(large_intestine)	SRRM4	200	0	358	24	0.06282722513089	TRUE	TRUE
ENSG00000185344.14	.	BCM	GRCh38.p13	chr12	123726262	123726262	+	G	G	A	Missense_Mutation	SNP	ENST00000330342.8	exon5	c.G498A	p.M166I	exonic	ENSG00000185344.14	.	nonsynonymous SNV	ENSG00000185344.14:ENST00000330342.8:exon5:c.G498A:p.M166I	12q24.31	C3L-01598	.	.	.	.	.	.	.	.	.	11.20	T	T	P	B	D	D	L	D	N	0.614	D	D	D	0.557	0.638	0.586	0.411	T	T	D	D	D	T	2.817	23.100	0.995	D	D	0.474	4.842	0.604	6.268	1.000	0.722	0.699	0.725	0.714	.	5.920	5.920	9.567	1.162	0.675	1.000	1.000	0.998	345	.	.	.	.	ATP6V0A2	309	0	483	31	0.0603112840466926	TRUE	TRUE
ENSG00000139517.9	.	BCM	GRCh38.p13	chr13	27562604	27562604	+	G	G	A	Missense_Mutation	SNP	ENST00000316334.5	exon5	c.C1033T	p.R345W	exonic	ENSG00000139517.9	.	nonsynonymous SNV	ENSG00000139517.9:ENST00000316334.5:exon5:c.C1033T:p.R345W	13q12.2	C3L-01598	1.648e-05	9.61e-05	0	0	0	0	0	6.056e-05	rs745613572	14.20	D	D	D	D	D	D	M	T	D	0.738	T	T	D	0.329	0.579	0.786	0.272	T	T	T	D	D	D	4.012	27.100	0.999	D	D	0.657	6.562	0.585	6.037	0.999	0.653	0.546	0.659	0.669	.	5.880	5.020	3.459	1.176	0.676	1.000	0.778	0.947	970	PDZ_domain	.	.	ID=COSV60338718;OCCURENCE=1(stomach),1(endometrium)	LNX2	355	0	616	75	0.108538350217077	TRUE	TRUE
ENSG00000174373.16	.	BCM	GRCh38.p13	chr14	35738515	35738515	+	G	G	A	Nonsense_Mutation	SNP	ENST00000389698.7	exon12	c.C1585T	p.Q529X	exonic	ENSG00000174373.16	.	stopgain	ENSG00000174373.16:ENST00000389698.7:exon12:c.C1585T:p.Q529X	14q13.2	C3L-01598	.	.	.	.	.	.	.	.	.	6.6	.	.	.	.	D	A	.	.	.	0.522	.	.	.	.	.	.	.	.	.	D	D	.	.	10.158	54	0.998	D	D	1.153	20.217	1.006	19.199	0.999	0.554	0.588	0.547	0.528	.	5.420	5.420	6.842	1.176	0.618	1.000	0.933	0.964	555	.	.	.	.	RALGAPA1	209	2	298	16	0.0509554140127389	NA	TRUE
ENSG00000151332.19	.	BCM	GRCh38.p13	chr14	36314532	36314532	+	T	T	C	Missense_Mutation	SNP	ENST00000416007.9	exon4	c.A551G	p.N184S	exonic	ENSG00000151332.19	.	nonsynonymous SNV	ENSG00000151332.19:ENST00000416007.9:exon4:c.A551G:p.N184S	14q13.3	C3L-01598	0.0004	0	0	0	0	0.0007	0	0	rs149685675	8.20	T	T	D	D	D	D	M	T	N	0.914	T	T	T	0.091	.	0.609	0.107	T	T	T	T	T	D	2.389	22.000	0.987	D	D	0.466	4.782	0.574	5.908	1.000	0.732	0.710	0.710	0.728	.	6.080	6.080	7.441	1.138	0.665	1.000	1.000	1.000	331	.	.	.	ID=COSV100576837;OCCURENCE=1(central_nervous_system)	MBIP	113	0	171	12	0.0655737704918033	TRUE	NA
ENSG00000119638.13	.	BCM	GRCh38.p13	chr14	75106525	75106525	+	T	T	C	Missense_Mutation	SNP	ENST00000238616.10	exon12	c.A1505G	p.Y502C	exonic	ENSG00000119638.13	.	nonsynonymous SNV	ENSG00000119638.13:ENST00000238616.10:exon12:c.A1505G:p.Y502C	14q24.3	C3L-01598	8.24e-06	0	0	0	0	1.499e-05	0	0	rs534245464	19.20	D	D	D	D	D	D	M	D	D	0.934	D	D	D	0.926	0.879	0.957	1.357	T	D	D	D	D	D	4.122	27.900	0.998	D	D	0.732	7.585	0.683	7.439	1.000	0.707	0.725	0.725	0.714	.	4.990	4.990	6.040	1.127	0.651	1.000	1.000	1.000	342	.	.	.	.	NEK9	413	0	734	55	0.0697084917617237	TRUE	NA
ENSG00000156218.13	.	BCM	GRCh38.p13	chr15	83991200	83991200	+	G	G	T	Missense_Mutation	SNP	ENST00000286744.10	exon23	c.G3959T	p.R1320L	exonic	ENSG00000156218.13	.	nonsynonymous SNV	ENSG00000156218.13:ENST00000286744.10:exon23:c.G3959T:p.R1320L	15q25.2	C3L-01598	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.476	T	T	D	0.230	0.710	0.555	0.217	T	T	T	T	T	T	1.079	12.560	0.968	N	N	-1.067	0.337	-1.162	0.316	1.000	0.601	0.597	0.618	0.564	.	5.210	-4.800	-0.182	-0.518	-0.642	0.003	0.774	0.884	623	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	ADAMTSL3	185	1	340	28	0.0760869565217391	TRUE	TRUE
ENSG00000154227.13	.	BCM	GRCh38.p13	chr15	100469382	100469382	+	A	A	G	Missense_Mutation	SNP	ENST00000284382.8	exon11	c.T841C	p.F281L	exonic	ENSG00000154227.13	.	nonsynonymous SNV	ENSG00000154227.13:ENST00000284382.8:exon11:c.T841C:p.F281L	15q26.3	C3L-01598	8.243e-06	0	0	0	0	0	0	6.058e-05	rs769131621	16.20	T	T	D	D	N	D	M	D	D	0.581	D	D	D	0.818	0.677	0.689	0.135	T	D	D	D	D	D	3.988	26.900	0.999	D	D	0.655	6.538	0.656	7.002	0.998	0.487	0.574	0.574	0.564	.	5.680	5.680	5.478	1.312	0.756	1.000	1.000	0.990	970	TRAM/LAG1/CLN8_homology_domain	.	.	.	CERS3	173	0	256	23	0.0824372759856631	TRUE	NA
ENSG00000103222.19	.	BCM	GRCh38.p13	chr16	16090516	16090516	+	C	C	G	Missense_Mutation	SNP	ENST00000399410.8	exon19	c.C2572G	p.R858G	exonic	ENSG00000103222.19	.	nonsynonymous SNV	ENSG00000103222.19:ENST00000399410.8:exon19:c.C2572G:p.R858G	16p13.11	C3L-01598	.	.	.	.	.	.	.	.	.	5.20	D	T	B	B	N	N	L	D	D	0.473	T	T	D	0.177	0.496	0.840	0.431	T	T	T	T	T	D	2.151	20.500	0.989	N	N	-0.235	1.780	-0.161	1.882	0.998	0.707	0.702	0.702	0.714	.	5.400	5.400	1.178	1.025	0.598	0.001	0.980	0.891	912	ABC_transporter-like;AAA+_ATPase_domain	.	.	.	ABCC1	156	0	320	23	0.0670553935860058	TRUE	NA
ENSG00000159708.18	.	BCM	GRCh38.p13	chr16	67375283	67375283	+	G	G	A	Missense_Mutation	SNP	ENST00000329956.11	exon10	c.G1531A	p.A511T	exonic	ENSG00000159708.18	.	nonsynonymous SNV	ENSG00000159708.18:ENST00000329956.11:exon10:c.G1531A:p.A511T	16q22.1	C3L-01598	.	.	.	.	.	.	.	.	.	2.19	D	T	B	B	N	D	N	T	N	0.070	T	T	.	0.039	0.222	0.262	0.211	T	T	T	T	T	T	1.947	18.850	0.989	N	N	-0.403	1.376	-0.282	1.601	0.995	0.516	0.547	0.547	0.586	.	5.690	2.670	0.641	-0.241	-0.250	1.000	0.991	0.995	22	.	.	.	.	LRRC36	275	0	643	41	0.0599415204678363	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675136	7675136	+	G	G	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.C476A	p.A159D	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.C476A:p.A159D	17p13.1	C3L-01598	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.857	D	D	D	0.836	0.920	0.976	2.017	T	D	D	D	D	D	3.578	25.000	0.990	D	D	0.322	3.896	0.157	2.980	0.990	0.722	0.698	0.698	0.735	.	5.590	2.420	8.150	1.176	0.676	1.000	0.917	0.632	434	p53,_DNA-binding_domain	.	.	ID=COSV52759722;OCCURENCE=1(oesophagus),6(large_intestine),2(central_nervous_system),1(stomach),1(haematopoietic_and_lymphoid_tissue),1(urinary_tract),1(prostate),1(lung)	TP53	357	2	522	62	0.106164383561644	TRUE	TRUE
ENSG00000240871.5	.	BCM	GRCh38.p13	chr17	41084327	41084327	+	C	C	T	Missense_Mutation	SNP	ENST00000391417.5	exon1	c.C121T	p.R41C	exonic	ENSG00000240871.5	.	nonsynonymous SNV	ENSG00000240871.5:ENST00000391417.5:exon1:c.C121T:p.R41C	17q21.2	C3L-01598	.	.	.	.	.	.	.	.	.	3.16	D	T	.	.	U	N	.	T	D	0.287	T	T	T	0.043	0.403	0.357	0.042	T	.	T	T	D	T	2.533	22.500	0.945	N	N	-0.381	1.425	-0.616	1.022	0.001	0.487	0.563	0.574	0.564	.	3.630	1.370	-0.370	0.126	0.507	0.013	0.037	0.033	408	.	.	.	ID=COSV66951250;OCCURENCE=1(stomach),1(urinary_tract)	KRTAP4-7	432	0	906	75	0.0764525993883792	NA	TRUE
ENSG00000166685.12	.	BCM	GRCh38.p13	chr17	73193376	73193376	+	G	G	A	Missense_Mutation	SNP	ENST00000299886.9	exon1	c.G307A	p.A103T	exonic	ENSG00000166685.12	.	nonsynonymous SNV	ENSG00000166685.12:ENST00000299886.9:exon1:c.G307A:p.A103T	17q25.1	C3L-01598	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.064	T	T	T	0.037	0.182	0.231	0.687	T	T	T	T	T	T	0.825	9.643	0.927	N	N	-0.932	0.482	-0.926	0.585	1.000	0.442	0.522	0.474	0.373	.	3.430	1.170	-0.006	0.153	-0.331	0.005	0.099	0.010	580	.	.	.	.	COG1	100	0	186	14	0.07	TRUE	NA
ENSG00000078898.7	.	BCM	GRCh38.p13	chr20	33021782	33021783	+	GA	GA	-	Frame_Shift_Del	DEL	ENST00000170150.4	exon15	c.1318_1319del	p.E440Dfs*5	exonic	ENSG00000078898.7	.	frameshift deletion	ENSG00000078898.7:ENST00000170150.4:exon15:c.1318_1319del:p.E440Dfs*5	20q11.21	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BPIFB2	274	1	512	30	0.0553505535055351	NA	TRUE
ENSG00000124143.10	.	BCM	GRCh38.p13	chr20	38623504	38623504	+	A	A	G	Missense_Mutation	SNP	ENST00000373345.8	exon2	c.A124G	p.R42G	exonic	ENSG00000124143.10	.	nonsynonymous SNV	ENSG00000124143.10:ENST00000373345.8:exon2:c.A124G:p.R42G	20q11.23	C3L-01598	.	.	.	.	.	.	.	.	.	0.17	T	T	.	.	.	N	L	T	N	0.140	T	T	T	0.015	0.218	0.284	.	T	T	T	T	T	T	0.736	8.786	0.733	N	N	-0.806	0.646	-0.932	0.578	0.314	0.516	0.590	0.602	0.586	.	4.170	-3.850	0.787	-0.120	-0.092	0.409	0.731	0.935	897	.	.	.	.	ARHGAP40	173	0	293	34	0.103975535168196	TRUE	TRUE
ENSG00000162669.16	.	BCM	GRCh38.p13	chr1	91315949	91315949	+	C	C	T	Silent	SNP	ENST00000370425.8	exon28	c.G3006A	p.T1002T	exonic	ENSG00000162669.16	.	synonymous SNV	ENSG00000162669.16:ENST00000370425.8:exon28:c.G3006A:p.T1002T	1p22.2	C3L-01598	.	.	.	.	.	.	.	.	rs773788286	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54023987;OCCURENCE=1(large_intestine)	HFM1	89	0	176	15	0.0785340314136126	TRUE	TRUE
ENSG00000143341.12	.	BCM	GRCh38.p13	chr1	186189863	186189863	+	C	C	T	Silent	SNP	ENST00000271588.9	exon107	c.C16893T	p.S5631S	exonic	ENSG00000143341.12	.	synonymous SNV	ENSG00000143341.12:ENST00000271588.9:exon107:c.C16893T:p.S5631S	1q31.1	C3L-01598	2.474e-05	0	0.0002	0	0	1.5e-05	0	0	rs200759463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HMCN1	318	0	413	35	0.078125	TRUE	NA
ENSG00000130508.11	.	BCM	GRCh38.p13	chr2	1648993	1648993	+	C	C	A	Silent	SNP	ENST00000252804.9	exon17	c.G2787T	p.L929L	exonic	ENSG00000130508.11	.	synonymous SNV	ENSG00000130508.11:ENST00000252804.9:exon17:c.G2787T:p.L929L	2p25.3	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PXDN	163	0	246	22	0.082089552238806	TRUE	TRUE
ENSG00000163295.5	.	BCM	GRCh38.p13	chr2	232458924	232458924	+	C	C	T	Silent	SNP	ENST00000295463.4	exon11	c.C1365T	p.D455D	exonic	ENSG00000163295.5	.	synonymous SNV	ENSG00000163295.5:ENST00000295463.4:exon11:c.C1365T:p.D455D	2q37.1	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55015571;OCCURENCE=1(large_intestine)	ALPI	259	0	529	106	0.166929133858268	TRUE	TRUE
ENSG00000156983.16	.	BCM	GRCh38.p13	chr3	9739302	9739302	+	C	C	T	Silent	SNP	ENST00000457855.1	exon2	c.C903T	p.H301H	exonic	ENSG00000156983.16	.	synonymous SNV	ENSG00000156983.16:ENST00000457855.1:exon2:c.C903T:p.H301H	3p25.3	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57403061;OCCURENCE=1(skin)	BRPF1	108	0	213	14	0.0616740088105727	TRUE	TRUE
ENSG00000187689.10	.	BCM	GRCh38.p13	chr4	70522817	70522817	+	A	A	G	Silent	SNP	ENST00000339336.9	exon3	c.A117G	p.P39P	exonic	ENSG00000187689.10	.	synonymous SNV	ENSG00000187689.10:ENST00000339336.9:exon3:c.A117G:p.P39P	4q13.3	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AMTN	291	2	514	31	0.0568807339449541	NA	TRUE
ENSG00000113430.10	.	BCM	GRCh38.p13	chr5	1878287	1878287	+	C	C	T	Silent	SNP	ENST00000231357.7	exon5	c.G1242A	p.P414P	exonic	ENSG00000113430.10	.	synonymous SNV	ENSG00000113430.10:ENST00000231357.7:exon5:c.G1242A:p.P414P	5p15.33	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51473850;OCCURENCE=1(breast),1(large_intestine)	IRX4	139	0	268	19	0.0662020905923345	TRUE	TRUE
ENSG00000244694.7	.	BCM	GRCh38.p13	chr6	47878921	47878921	+	G	G	A	Silent	SNP	ENST00000339488.8	exon3	c.C1923T	p.I641I	exonic	ENSG00000244694.7	.	synonymous SNV	ENSG00000244694.7:ENST00000339488.8:exon3:c.C1923T:p.I641I	6p12.3	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59778738;OCCURENCE=1(large_intestine),2(skin)	PTCHD4	395	0	590	53	0.0824261275272162	TRUE	TRUE
ENSG00000156395.13	.	BCM	GRCh38.p13	chr10	104641642	104641642	+	C	C	T	Silent	SNP	ENST00000369701.8	exon1	c.C315T	p.A105A	exonic	ENSG00000156395.13	.	synonymous SNV	ENSG00000156395.13:ENST00000369701.8:exon1:c.C315T:p.A105A	10q25.1	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SORCS3	148	0	344	26	0.0702702702702703	TRUE	TRUE
ENSG00000124942.14	.	BCM	GRCh38.p13	chr11	62518175	62518175	+	A	A	G	Silent	SNP	ENST00000378024.9	exon5	c.T16242C	p.S5414S	exonic	ENSG00000124942.14	.	synonymous SNV	ENSG00000124942.14:ENST00000378024.9:exon5:c.T16242C:p.S5414S	11q12.3	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AHNAK	238	0	439	34	0.0718816067653277	TRUE	TRUE
ENSG00000135424.18	.	BCM	GRCh38.p13	chr12	55702929	55702929	+	C	C	T	Silent	SNP	ENST00000555728.5	exon3	c.G357A	p.K119K	exonic	ENSG00000135424.18	.	synonymous SNV	ENSG00000135424.18:ENST00000555728.5:exon3:c.G357A:p.K119K	12q13.2	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITGA7	617	0	1046	81	0.0718722271517303	TRUE	TRUE
ENSG00000198855.7	.	BCM	GRCh38.p13	chr12	108518938	108518938	+	G	G	A	Silent	SNP	ENST00000552695.6	exon3	c.G840A	p.S280S	exonic	ENSG00000198855.7	.	synonymous SNV	ENSG00000198855.7:ENST00000552695.6:exon3:c.G840A:p.S280S	12q23.3	C3L-01598	3.302e-05	0	0	0	0	4.506e-05	0	6.058e-05	rs375100196	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FICD	327	0	559	54	0.0880913539967374	TRUE	NA
ENSG00000078328.21	.	BCM	GRCh38.p13	chr16	7518266	7518266	+	G	G	A	Silent	SNP	ENST00000550418.6	exon5	c.G147A	p.A49A	exonic	ENSG00000078328.21	.	synonymous SNV	ENSG00000078328.21:ENST00000550418.6:exon5:c.G147A:p.A49A	16p13.3	C3L-01598	8.239e-06	0	0	0	0	0	0	6.056e-05	rs752770034	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60957261;OCCURENCE=1(oesophagus),2(large_intestine)	RBFOX1	222	0	335	21	0.0589887640449438	TRUE	TRUE
ENSG00000076351.13	.	BCM	GRCh38.p13	chr17	28405319	28405319	+	G	G	A	Silent	SNP	ENST00000612814.5	exon2	c.C378T	p.L126L	exonic	ENSG00000076351.13	.	synonymous SNV	ENSG00000076351.13:ENST00000612814.5:exon2:c.C378T:p.L126L	17q11.2	C3L-01598	2.365e-05	0	0	0	0	4.232e-05	0	0	rs375678730	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC46A1	203	0	842	93	0.0994652406417112	TRUE	NA
ENSG00000278540.5	.	BCM	GRCh38.p13	chr17	37192114	37192114	+	G	G	A	Silent	SNP	ENST00000614428.4	exon37	c.C4281T	p.I1427I	exonic	ENSG00000278540.5	.	synonymous SNV	ENSG00000278540.5:ENST00000614428.4:exon37:c.C4281T:p.I1427I	17q12	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACACA	423	0	646	47	0.0678210678210678	TRUE	TRUE
ENSG00000161270.19	.	BCM	GRCh38.p13	chr19	35831347	35831347	+	G	G	A	Silent	SNP	ENST00000378910.9	exon26	c.C3336T	p.N1112N	exonic	ENSG00000161270.19	.	synonymous SNV	ENSG00000161270.19:ENST00000378910.9:exon26:c.C3336T:p.N1112N	19q13.12	C3L-01598	.	.	.	.	.	.	.	.	rs1053234526	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62289633;OCCURENCE=1(ovary)	NPHS1	517	1	932	69	0.0689310689310689	TRUE	TRUE
ENSG00000169297.8	.	BCM	GRCh38.p13	chrX	30309076	30309076	+	C	C	T	Silent	SNP	ENST00000378970.5	exon1	c.G288A	p.A96A	exonic	ENSG00000169297.8	.	synonymous SNV	ENSG00000169297.8:ENST00000378970.5:exon1:c.G288A:p.A96A	Xp21.2	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66764071;OCCURENCE=1(breast),2(large_intestine)	NR0B1	370	0	706	62	0.0807291666666667	TRUE	TRUE
ENSG00000046774.10	.	BCM	GRCh38.p13	chrX	142202890	142202890	+	G	G	A	Silent	SNP	ENST00000247452.4	exon3	c.C1098T	p.S366S	exonic	ENSG00000046774.10	.	synonymous SNV	ENSG00000046774.10:ENST00000247452.4:exon3:c.C1098T:p.S366S	Xq27.2	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAGEC2	136	0	211	22	0.0944206008583691	TRUE	TRUE
ENSG00000144228.9	.	BCM	GRCh38.p13	chr2	138554456	138554456	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000144228.9	.	.	.	2q22.1	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPOPL	82	0	151	13	0.0792682926829268	TRUE	NA
ENSG00000155111.15	.	BCM	GRCh38.p13	chr6	110643213	110643213	+	A	A	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000155111.15	.	.	.	6q21	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDK19	229	0	320	27	0.0778097982708934	TRUE	NA
ENSG00000257228.5	.	BCM	GRCh38.p13	chr12	41437978	41437978	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000257228.5	.	.	.	12q12	C3L-01598	.	.	.	.	.	.	.	.	.	9.17	D	D	D	D	N	D	.	T	N	0.590	T	T	T	0.248	0.339	0.461	.	.	.	T	T	D	D	2.284	21.500	0.995	D	D	0.783	8.454	0.782	9.614	1.000	0.487	0.574	0.492	0.613	.	4.960	4.960	9.323	1.176	0.676	1.000	1.000	1.000	681	.	.	.	.	AC090531.1	350	0	542	37	0.0639032815198618	TRUE	NA
ENSG00000229373.9	.	BCM	GRCh38.p13	chr13	113919527	113919527	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000229373.9	.	.	.	13q34	C3L-01598	0.0010	0	0	0	0	0	0	0.0016	rs772152045	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC00452	236	0	344	35	0.0923482849604222	TRUE	NA
ENSG00000207649.3	.	BCM	GRCh38.p13	chr16	56858592	56858592	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000207649.3	.	.	.	16q13	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR138-2	44	0	171	12	0.0655737704918033	TRUE	NA
ENSG00000226137.5	.	BCM	GRCh38.p13	chr17	81032954	81032954	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000226137.5	.	.	.	17q25.3	C3L-01598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BAIAP2-DT	241	1	439	34	0.0718816067653277	TRUE	NA
ENSG00000089327.15	.	BCM	GRCh38.p13	chr19	35159540	35159540	+	T	T	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000089327.15	.	.	.	19q13.12	C3L-01598	.	.	.	.	.	.	.	.	.	0.15	T	T	.	.	.	N	.	T	N	0.099	T	T	T	0.005	0.431	0.188	.	.	T	T	T	T	T	0.078	1.897	0.655	N	N	-0.721	0.778	-0.946	0.558	1.000	0.372	0.546	0.464	0.492	.	2.160	-0.563	-0.860	0.555	0.494	0.000	0.450	0.242	917	.	.	.	.	FXYD5	229	0	345	28	0.0750670241286863	TRUE	TRUE
ENSG00000117713.20	.	BCM	GRCh38.p13	chr1	26697194	26697194	+	C	C	A	Nonsense_Mutation	SNP	ENST00000324856.13	exon1	c.C791A	p.S264X	exonic	ENSG00000117713.20	.	stopgain	ENSG00000117713.20:ENST00000324856.13:exon1:c.C791A:p.S264X	1p36.11	C3L-00599	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	U	A	.	.	.	0.622	.	.	.	.	.	.	.	.	.	D	D	.	.	7.011	37	0.990	D	N	0.636	6.313	0.451	4.740	1.000	0.442	0.522	0.522	0.581	.	3.520	3.520	3.810	0.915	0.446	1.000	1.000	0.997	550	.	.	.	ID=COSV61381323;OCCURENCE=1(oesophagus),1(endometrium)	ARID1A	36	0	69	6	0.08	TRUE	TRUE
ENSG00000127125.9	.	BCM	GRCh38.p13	chr1	42457258	42457262	+	ATGTT	ATGTT	-	Frame_Shift_Del	DEL	ENST00000372561.4	exon2	c.520_524del	p.M174Lfs*15	exonic	ENSG00000127125.9	.	frameshift deletion	ENSG00000127125.9:ENST00000372561.4:exon2:c.520_524del:p.M174Lfs*15	1p34.2	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPCS	160	0	218	30	0.120967741935484	TRUE	TRUE
ENSG00000143552.9	.	BCM	GRCh38.p13	chr1	154058167	154058167	+	G	G	A	Missense_Mutation	SNP	ENST00000368559.7	exon22	c.C3029T	p.S1010F	exonic	ENSG00000143552.9	.	nonsynonymous SNV	ENSG00000143552.9:ENST00000368559.7:exon22:c.C3029T:p.S1010F	1q21.3	C3L-00599	.	.	.	.	.	.	.	.	.	3.20	T	T	P	P	N	D	L	T	N	0.369	T	T	T	0.127	0.449	0.690	0.612	T	T	T	T	D	T	3.069	23.600	0.988	D	N	0.224	3.412	0.217	3.267	0.000	0.487	0.590	0.574	0.479	.	4.760	3.860	3.761	1.176	0.676	1.000	0.957	0.625	85	.	.	.	ID=COSV55157757;OCCURENCE=1(stomach),1(skin)	NUP210L	174	0	359	31	0.0794871794871795	TRUE	TRUE
ENSG00000143507.18	.	BCM	GRCh38.p13	chr1	221702429	221702429	+	C	C	T	Missense_Mutation	SNP	ENST00000366899.4	exon4	c.G1432A	p.V478M	exonic	ENSG00000143507.18	.	nonsynonymous SNV	ENSG00000143507.18:ENST00000366899.4:exon4:c.G1432A:p.V478M	1q41	C3L-00599	6.594e-05	0	0	0.0006	0	4.499e-05	0	0	rs546305993	5.20	T	D	D	B	N	D	L	T	N	0.109	T	T	T	0.121	0.292	0.393	0.359	T	T	T	T	T	D	2.621	22.700	0.988	D	N	-0.033	2.397	0.085	2.672	1.000	0.632	0.698	0.602	0.621	.	5.720	4.800	3.243	0.138	0.599	0.995	0.928	0.652	914	.	.	.	ID=COSV60457434;OCCURENCE=1(stomach)	DUSP10	150	0	292	16	0.051948051948052	TRUE	TRUE
ENSG00000077522.13	.	BCM	GRCh38.p13	chr1	236731272	236731272	+	G	G	A	Missense_Mutation	SNP	ENST00000366578.6	exon7	c.G655A	p.A219T	exonic	ENSG00000077522.13	.	nonsynonymous SNV	ENSG00000077522.13:ENST00000366578.6:exon7:c.G655A:p.A219T	1q43	C3L-00599	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.882	D	D	D	0.807	0.859	0.881	1.942	T	D	D	D	D	D	4.262	29.200	0.999	D	D	1.098	17.436	0.966	16.881	1.000	0.554	0.547	0.602	0.621	.	4.870	4.870	9.998	1.176	0.676	1.000	0.658	0.893	427	Calponin_homology_domain	.	.	ID=COSV63978630;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	ACTN2	258	1	567	37	0.0612582781456954	TRUE	TRUE
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237733718	237733718	+	G	G	A	Missense_Mutation	SNP	ENST00000366574.7	exon79	c.G11053A	p.D3685N	exonic	ENSG00000198626.17	.	nonsynonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon79:c.G11053A:p.D3685N	1q43	C3L-00599	.	.	.	.	.	.	.	.	.	18.19	D	.	D	D	U	D	M	D	D	0.847	D	D	D	0.804	0.445	0.975	1.569	D	D	D	D	D	D	4.807	33	0.999	D	D	0.990	13.626	0.952	16.174	1.000	0.554	0.574	0.602	0.564	.	5.790	5.790	9.593	1.176	0.676	1.000	1.000	0.996	818	.	.	.	.	RYR2	221	0	419	35	0.0770925110132159	TRUE	TRUE
ENSG00000075426.12	.	BCM	GRCh38.p13	chr2	28408795	28408795	+	C	C	T	Missense_Mutation	SNP	ENST00000264716.9	exon3	c.C391T	p.R131W	exonic	ENSG00000075426.12	.	nonsynonymous SNV	ENSG00000075426.12:ENST00000264716.9:exon3:c.C391T:p.R131W	2p23.2	C3L-00599	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.830	D	D	D	0.831	0.600	0.938	3.317	D	D	D	D	D	D	4.104	27.800	0.998	D	D	0.257	3.566	0.146	2.931	1.000	0.731	0.670	0.659	0.649	.	5.450	3.030	1.571	-0.162	-0.700	1.000	0.995	0.945	448	Basic-leucine_zipper_domain	.	.	ID=COSV53103773;OCCURENCE=2(large_intestine),1(biliary_tract)	FOSL2	67	0	232	22	0.0866141732283465	TRUE	TRUE
ENSG00000144057.15	.	BCM	GRCh38.p13	chr2	106843434	106843434	+	T	T	C	Missense_Mutation	SNP	ENST00000409382.7	exon2	c.A544G	p.R182G	exonic	ENSG00000144057.15	.	nonsynonymous SNV	ENSG00000144057.15:ENST00000409382.7:exon2:c.A544G:p.R182G	2q12.3	C3L-00599	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.088	T	T	T	0.018	0.296	0.072	0.633	T	T	T	T	T	T	0.433	5.787	0.953	N	N	-1.155	0.261	-1.161	0.317	0.544	0.646	0.574	0.645	0.564	.	5.090	-4.430	-0.120	-0.028	0.580	0.000	0.010	0.879	872	.	.	.	.	ST6GAL2	176	0	386	57	0.128668171557562	TRUE	TRUE
ENSG00000226321.5	.	BCM	GRCh38.p13	chr2	240959324	240959324	+	G	G	T	Missense_Mutation	SNP	ENST00000443866.2	exon20	c.G2973T	p.E991D	exonic	ENSG00000226321.5	.	nonsynonymous SNV	ENSG00000226321.5:ENST00000443866.2:exon20:c.G2973T:p.E991D	2q37.3	C3L-00599	.	.	.	.	.	.	.	.	.	0.9	.	T	.	.	.	.	.	.	.	0.059	T	T	.	0.022	.	0.048	.	.	T	T	T	T	.	0.913	10.570	0.879	N	N	-0.758	0.718	-0.931	0.578	1.000	0.581	0.563	0.576	0.613	.	3.390	-2.060	0.204	0.245	0.616	0.084	0.527	0.727	970	.	.	.	.	CROCC2	112	0	231	29	0.111538461538462	TRUE	TRUE
ENSG00000082684.16	.	BCM	GRCh38.p13	chr3	122913279	122913279	+	G	G	A	Missense_Mutation	SNP	ENST00000357599.8	exon17	c.C2426T	p.P809L	exonic	ENSG00000082684.16	.	nonsynonymous SNV	ENSG00000082684.16:ENST00000357599.8:exon17:c.C2426T:p.P809L	3q21.1	C3L-00599	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.955	T	T	D	0.418	0.407	0.808	0.402	T	T	D	D	D	D	4.293	29.500	0.999	D	D	0.830	9.405	0.785	9.695	1.000	0.788	0.574	0.000	0.530	.	4.640	4.640	9.819	1.073	0.674	1.000	0.979	0.945	708	.	.	.	ID=COSV52094717;OCCURENCE=1(oesophagus),1(skin),1(prostate)	SEMA5B	148	0	431	34	0.0731182795698925	TRUE	TRUE
ENSG00000047662.5	.	BCM	GRCh38.p13	chr4	17709628	17709628	+	T	T	A	Missense_Mutation	SNP	ENST00000265018.4	exon2	c.A158T	p.N53I	exonic	ENSG00000047662.5	.	nonsynonymous SNV	ENSG00000047662.5:ENST00000265018.4:exon2:c.A158T:p.N53I	4p15.31	C3L-00599	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.867	D	D	D	0.636	0.405	0.466	.	T	T	D	D	D	T	4.056	27.400	0.990	D	D	0.664	6.646	0.629	6.609	1.000	0.554	0.588	0.602	0.564	.	5.170	5.170	4.886	1.138	0.665	1.000	0.998	0.993	790	Protein_FAM184A/B,_N-terminal	.	.	.	FAM184B	46	0	101	9	0.0818181818181818	TRUE	TRUE
ENSG00000109436.8	.	BCM	GRCh38.p13	chr4	140622446	140622446	+	C	C	T	Missense_Mutation	SNP	ENST00000442267.3	exon21	c.G3550A	p.G1184R	exonic	ENSG00000109436.8	.	nonsynonymous SNV	ENSG00000109436.8:ENST00000442267.3:exon21:c.G3550A:p.G1184R	4q31.21	C3L-00599	1.675e-05	0	0	0	0	1.518e-05	0	6.086e-05	rs778747040	9.20	D	D	D	P	D	D	L	T	N	0.348	T	T	T	0.080	.	0.043	1.097	T	T	T	T	D	D	3.568	24.900	0.996	D	D	0.213	3.359	0.172	3.048	1.000	0.707	0.634	0.659	0.714	.	5.010	4.170	5.841	1.026	0.599	1.000	0.814	0.969	878	.	.	.	.	TBC1D9	175	1	375	21	0.053030303030303	TRUE	NA
ENSG00000064651.14	.	BCM	GRCh38.p13	chr5	128131082	128131082	+	T	T	C	Missense_Mutation	SNP	ENST00000262461.7	exon5	c.T1064C	p.L355S	exonic	ENSG00000064651.14	.	nonsynonymous SNV	ENSG00000064651.14:ENST00000262461.7:exon5:c.T1064C:p.L355S	5q23.3	C3L-00599	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.930	D	D	D	0.968	0.759	0.930	2.045	D	D	D	D	D	D	4.290	29.500	0.999	D	D	0.917	11.485	0.816	10.621	1.000	0.651	0.709	0.653	0.646	.	4.930	4.930	7.674	1.138	0.665	1.000	1.000	0.997	762	Amino_acid_permease/_SLC12A_domain	.	.	.	SLC12A2	151	0	257	16	0.0586080586080586	TRUE	TRUE
ENSG00000160883.11	.	BCM	GRCh38.p13	chr5	176889487	176889487	+	C	C	T	Missense_Mutation	SNP	ENST00000292432.10	exon8	c.G808A	p.V270I	exonic	ENSG00000160883.11	.	nonsynonymous SNV	ENSG00000160883.11:ENST00000292432.10:exon8:c.G808A:p.V270I	5q35.2	C3L-00599	2.477e-05	9.658e-05	8.651e-05	0	0	1.503e-05	0	0	rs150272942	3.20	T	T	B	B	N	N	N	D	N	0.154	T	D	D	0.257	.	0.742	0.099	T	T	T	T	T	T	-0.756	0.032	0.219	N	N	-1.247	0.195	-1.164	0.314	0.944	0.516	0.610	0.602	0.542	.	5.480	1.670	-0.828	0.129	-0.232	0.000	0.106	0.008	547	Hexokinase,_C-terminal	.	.	ID=COSV52838042;OCCURENCE=1(large_intestine)	HK3	249	0	391	39	0.0906976744186047	TRUE	TRUE
ENSG00000232040.4	.	BCM	GRCh38.p13	chr6	28573526	28573526	+	C	C	A	Missense_Mutation	SNP	ENST00000452236.3	exon4	c.G2363T	p.S788I	exonic	ENSG00000232040.4	.	nonsynonymous SNV	ENSG00000232040.4:ENST00000452236.3:exon4:c.G2363T:p.S788I	6p22.1	C3L-00599	.	.	.	.	.	.	.	.	.	4.20	T	D	D	D	U	N	L	T	N	0.377	T	T	T	0.071	0.250	0.397	1.205	T	T	T	T	D	T	2.633	22.700	0.992	N	N	0.237	3.469	0.170	3.041	0.819	0.554	0.588	0.602	0.530	.	2.270	2.270	1.858	0.877	0.599	1.000	1.000	0.998	680	.	.	.	.	ZBED9	224	0	357	53	0.129268292682927	TRUE	TRUE
ENSG00000007866.21	.	BCM	GRCh38.p13	chr6	35486559	35486559	+	C	C	T	Nonsense_Mutation	SNP	ENST00000338863.12	exon2	c.G104A	p.W35X	exonic	ENSG00000007866.21	.	stopgain	ENSG00000007866.21:ENST00000338863.12:exon2:c.G104A:p.W35X	6p21.31	C3L-00599	.	.	.	.	.	.	.	.	.	6.8	.	.	.	.	D	D	.	.	.	.	.	.	D	.	.	.	.	.	.	T	T	D	.	7.234	37	0.994	D	D	0.862	10.106	0.722	8.193	1.000	0.554	0.547	0.522	0.568	.	5.150	5.150	7.896	1.026	0.547	1.000	1.000	0.998	607	TEA/ATTS_domain	.	.	.	TEAD3	209	0	467	26	0.0527383367139959	TRUE	NA
ENSG00000135250.17	.	BCM	GRCh38.p13	chr7	105143317	105143317	+	G	G	A	Missense_Mutation	SNP	ENST00000357311.7	exon9	c.C794T	p.S265F	exonic	ENSG00000135250.17	.	nonsynonymous SNV	ENSG00000135250.17:ENST00000357311.7:exon9:c.C794T:p.S265F	7q22.3	C3L-00599	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.698	T	T	D	0.413	0.288	0.599	2.079	T	T	D	T	D	D	4.404	31	0.998	D	D	0.911	11.332	0.895	13.554	1.000	0.563	0.654	0.602	0.492	.	5.680	5.680	9.332	1.176	0.676	1.000	1.000	1.000	683	Protein_kinase_domain	.	.	ID=COSV100623721;OCCURENCE=1(skin)	SRPK2	98	0	232	29	0.111111111111111	TRUE	TRUE
ENSG00000133612.19	.	BCM	GRCh38.p13	chr7	151117765	151117765	+	G	G	A	Missense_Mutation	SNP	ENST00000622464.4	exon6	c.G586A	p.V196M	exonic	ENSG00000133612.19	.	nonsynonymous SNV	ENSG00000133612.19:ENST00000622464.4:exon6:c.G586A:p.V196M	7q36.1	C3L-00599	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	H	T	D	0.863	D	D	D	0.674	0.698	0.834	2.586	D	D	D	D	D	D	4.376	31	0.999	D	D	0.890	10.806	0.782	9.619	1.000	0.707	0.702	0.723	0.714	.	4.290	4.290	8.129	1.157	0.595	1.000	0.999	0.997	940	.	.	.	.	AGAP3	73	1	170	23	0.119170984455959	TRUE	TRUE
ENSG00000137055.15	.	BCM	GRCh38.p13	chr9	26905581	26905584	+	TTTA	TTTA	-	Frame_Shift_Del	DEL	ENST00000397292.8	exon14	c.2315_2318del	p.I772Kfs*12	exonic	ENSG00000137055.15	.	frameshift deletion	ENSG00000137055.15:ENST00000397292.8:exon14:c.2315_2318del:p.I772Kfs*12	9p21.2	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLAA	129	0	164	30	0.154639175257732	TRUE	TRUE
ENSG00000172159.16	.	BCM	GRCh38.p13	chr9	83313738	83313738	+	G	G	C	Missense_Mutation	SNP	ENST00000304195.8	exon7	c.C606G	p.S202R	exonic	ENSG00000172159.16	.	nonsynonymous SNV	ENSG00000172159.16:ENST00000304195.8:exon7:c.C606G:p.S202R	9q21.32	C3L-00599	.	.	.	.	.	.	.	.	.	15.20	D	D	B	B	D	D	M	D	N	0.537	D	D	D	0.559	0.546	0.775	0.334	T	D	D	T	D	D	2.451	22.300	0.993	D	D	-0.033	2.397	-0.008	2.331	0.004	0.554	0.574	0.602	0.568	.	5.900	1.430	1.208	1.176	0.676	1.000	0.997	0.927	948	0.000	.	.	.	FRMD3	145	0	316	17	0.0510510510510511	TRUE	NA
ENSG00000110442.12	.	BCM	GRCh38.p13	chr11	36278499	36278499	+	T	T	C	Missense_Mutation	SNP	ENST00000263401.10	exon3	c.A295G	p.T99A	exonic	ENSG00000110442.12	.	nonsynonymous SNV	ENSG00000110442.12:ENST00000263401.10:exon3:c.A295G:p.T99A	11p13	C3L-00599	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	D	D	M	T	D	0.878	T	T	T	0.191	0.570	0.324	0.539	T	T	D	T	D	D	3.315	24.200	0.996	D	D	0.457	4.717	0.535	5.493	1.000	0.713	0.725	0.636	0.714	.	5.910	5.910	6.696	1.138	0.665	1.000	0.999	0.992	902	.	.	.	.	COMMD9	237	0	416	37	0.0816777041942605	TRUE	TRUE
ENSG00000130037.5	.	BCM	GRCh38.p13	chr12	5045048	5045048	+	A	A	G	Missense_Mutation	SNP	ENST00000252321.5	exon1	c.A901G	p.S301G	exonic	ENSG00000130037.5	.	nonsynonymous SNV	ENSG00000130037.5:ENST00000252321.5:exon1:c.A901G:p.S301G	12p13.32	C3L-00599	.	.	.	.	.	.	.	.	.	9.20	T	T	P	B	N	N	L	D	N	0.234	D	D	D	0.407	0.201	1.000	0.594	T	D	D	D	T	T	1.639	16.630	0.976	D	D	-0.024	2.427	0.068	2.605	0.944	0.598	0.590	0.596	0.542	.	4.770	4.770	3.515	0.265	-0.118	0.951	0.013	0.019	680	Ion_transport_domain	.	.	.	KCNA5	202	0	353	20	0.0536193029490617	TRUE	TRUE
ENSG00000121380.12	.	BCM	GRCh38.p13	chr12	12094797	12094797	+	A	A	C	Missense_Mutation	SNP	ENST00000308721.9	exon5	c.A812C	p.K271T	exonic	ENSG00000121380.12	.	nonsynonymous SNV	ENSG00000121380.12:ENST00000308721.9:exon5:c.A812C:p.K271T	12p13.2	C3L-00599	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	D	D	M	T	D	0.644	T	T	D	0.294	0.513	0.533	0.613	T	T	T	T	D	.	3.245	24.000	0.998	D	N	0.440	4.600	0.353	4.042	0.910	0.615	0.588	0.659	0.635	.	4.730	2.440	2.670	1.312	0.756	1.000	0.983	0.797	964	.	.	.	.	BCL2L14	368	1	682	85	0.110821382007823	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-00599	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	274	2	400	76	0.159663865546218	TRUE	TRUE
ENSG00000118946.12	.	BCM	GRCh38.p13	chr13	57634446	57634446	+	C	C	A	Missense_Mutation	SNP	ENST00000377918.8	exon1	c.C1900A	p.H634N	exonic	ENSG00000118946.12	.	nonsynonymous SNV	ENSG00000118946.12:ENST00000377918.8:exon1:c.C1900A:p.H634N	13q21.1	C3L-00599	.	.	.	.	.	.	.	.	.	4.20	T	T	P	P	D	D	N	T	N	0.318	T	T	T	0.142	0.531	0.615	.	T	T	T	T	D	T	3.198	23.900	0.956	D	N	0.217	3.377	0.327	3.876	1.000	0.583	0.574	0.615	0.568	.	5.500	3.620	3.921	1.019	0.591	1.000	1.000	0.999	835	Cadherin-like	.	.	.	PCDH17	225	0	492	122	0.198697068403909	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673799	7673799	+	A	A	C	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.T821G	p.V274G	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.T821G:p.V274G	17p13.1	C3L-00599	.	.	.	.	.	.	.	.	rs1057520006	18.20	D	D	D	D	N	D	M	D	D	0.569	D	D	D	0.865	0.792	0.968	0.435	T	D	D	D	D	D	4.121	27.900	0.997	D	D	0.750	7.875	0.657	7.022	1.000	0.722	0.702	0.725	0.735	.	4.920	4.920	9.325	1.307	0.751	0.980	0.981	0.989	432	p53,_DNA-binding_domain	.	.	ID=COSV52761348;OCCURENCE=8(breast),1(liver),2(large_intestine),1(central_nervous_system),1(ovary),1(stomach),1(haematopoietic_and_lymphoid_tissue),1(prostate),2(lung),1(endometrium)	TP53	583	2	828	128	0.133891213389121	TRUE	TRUE
ENSG00000189051.5	.	BCM	GRCh38.p13	chr17	8393131	8393131	+	C	C	T	Missense_Mutation	SNP	ENST00000399398.2	exon3	c.G331A	p.A111T	exonic	ENSG00000189051.5	.	nonsynonymous SNV	ENSG00000189051.5:ENST00000399398.2:exon3:c.G331A:p.A111T	17p13.1	C3L-00599	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	.	N	0.016	T	T	T	0.004	0.171	0.014	.	T	T	T	T	T	T	-0.465	0.141	0.844	N	N	-1.480	0.088	-1.462	0.123	0.972	0.403	0.547	0.578	0.563	.	4.210	-1.370	-0.405	-0.333	-0.328	0.000	0.000	0.001	283	.	.	.	.	RNF222	56	0	104	13	0.111111111111111	TRUE	NA
ENSG00000170310.15	.	BCM	GRCh38.p13	chr17	9491904	9491904	+	C	C	T	Missense_Mutation	SNP	ENST00000306357.9	exon6	c.G466A	p.D156N	exonic	ENSG00000170310.15	.	nonsynonymous SNV	ENSG00000170310.15:ENST00000306357.9:exon6:c.G466A:p.D156N	17p13.1	C3L-00599	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	M	.	D	0.631	T	T	D	0.648	0.731	0.477	0.220	T	T	T	T	D	D	4.030	27.200	0.999	D	D	0.691	6.998	0.643	6.810	0.998	0.706	0.710	0.659	0.613	.	5.880	4.910	5.190	1.022	0.545	1.000	0.994	0.991	912	Target_SNARE_coiled-coil_homology_domain	.	.	.	STX8	147	0	280	29	0.0938511326860841	TRUE	TRUE
ENSG00000166292.12	.	BCM	GRCh38.p13	chr17	55720907	55720907	+	C	C	T	Missense_Mutation	SNP	ENST00000424486.3	exon2	c.G164A	p.R55H	exonic	ENSG00000166292.12	.	nonsynonymous SNV	ENSG00000166292.12:ENST00000424486.3:exon2:c.G164A:p.R55H	17q22	C3L-00599	4.942e-05	9.61e-05	0	0	0	4.495e-05	0	0.0001	rs746630975	16.19	D	D	D	D	D	D	M	.	D	0.852	T	T	D	0.736	.	0.248	1.018	T	D	D	D	D	D	4.037	27.300	1.000	D	D	0.830	9.397	0.816	10.616	1.000	0.554	0.563	0.602	0.542	.	5.790	5.790	5.777	1.026	0.599	1.000	1.000	0.998	899	.	.	.	ID=COSV70118095;OCCURENCE=1(endometrium)	TMEM100	178	0	421	45	0.0965665236051502	TRUE	TRUE
ENSG00000062725.10	.	BCM	GRCh38.p13	chr17	60479182	60479182	+	G	G	T	Missense_Mutation	SNP	ENST00000083182.8	exon4	c.C469A	p.L157I	exonic	ENSG00000062725.10	.	nonsynonymous SNV	ENSG00000062725.10:ENST00000083182.8:exon4:c.C469A:p.L157I	17q23.2	C3L-00599	.	.	.	.	.	.	.	.	.	8.20	T	T	P	P	D	D	N	T	N	0.370	T	T	D	0.304	0.497	0.433	0.967	D	T	T	T	D	D	3.157	23.800	0.967	D	D	0.448	4.655	0.532	5.466	1.000	0.745	0.732	0.725	0.714	.	5.300	5.300	6.311	1.176	0.676	1.000	1.000	0.999	640	.	.	.	.	APPBP2	123	1	252	32	0.112676056338028	TRUE	TRUE
ENSG00000129646.14	.	BCM	GRCh38.p13	chr17	76282066	76282066	+	G	G	A	Missense_Mutation	SNP	ENST00000262765.10	exon8	c.C3563T	p.T1188M	exonic	ENSG00000129646.14	.	nonsynonymous SNV	ENSG00000129646.14:ENST00000262765.10:exon8:c.C3563T:p.T1188M	17q25.1	C3L-00599	5.164e-05	0	0.0004	0	0	0	0	0.0001	rs200506337	7.19	D	D	D	D	.	N	L	T	D	0.352	T	T	D	0.126	.	0.355	0.687	T	T	T	T	T	T	3.521	24.800	0.999	D	N	0.558	5.523	0.570	5.863	1.000	0.646	0.588	0.602	0.700	.	5.380	5.380	4.966	1.176	0.676	0.968	0.950	0.926	964	.	.	.	ID=COSV53158270;OCCURENCE=1(large_intestine)	QRICH2	108	0	290	23	0.073482428115016	TRUE	TRUE
ENSG00000095066.11	.	BCM	GRCh38.p13	chr19	12766151	12766151	+	T	T	C	Missense_Mutation	SNP	ENST00000397668.7	exon15	c.A1463G	p.H488R	exonic	ENSG00000095066.11	.	nonsynonymous SNV	ENSG00000095066.11:ENST00000397668.7:exon15:c.A1463G:p.H488R	19p13.13	C3L-00599	.	.	.	.	.	.	.	.	.	0.20	T	T	P	B	N	N	L	T	N	0.223	T	T	T	0.042	0.286	0.212	0.380	T	T	T	T	T	T	2.251	21.200	0.937	N	N	-0.078	2.246	0.038	2.495	1.000	0.658	0.404	0.780	0.297	.	4.770	4.770	2.145	1.123	0.590	1.000	1.000	0.986	624	.	.	.	.	HOOK2	117	0	330	30	0.0833333333333333	TRUE	TRUE
ENSG00000124191.18	.	BCM	GRCh38.p13	chr20	44065875	44065875	+	G	G	A	Missense_Mutation	SNP	ENST00000358131.5	exon6	c.G1070A	p.R357Q	exonic	ENSG00000124191.18	.	nonsynonymous SNV	ENSG00000124191.18:ENST00000358131.5:exon6:c.G1070A:p.R357Q	20q13.12	C3L-00599	7.575e-05	0	0	0.0002	0	9.201e-05	0	6.157e-05	rs773686339	5.20	T	T	D	D	N	D	L	T	N	0.267	T	T	T	0.127	0.305	0.217	1.049	T	T	T	T	T	D	3.512	24.700	0.998	D	N	0.067	2.757	0.049	2.536	0.176	0.615	0.634	0.576	0.655	.	5.110	4.160	5.442	1.172	0.672	1.000	0.995	0.941	754	.	.	.	ID=COSV57882392;OCCURENCE=2(large_intestine),1(pancreas),2(skin),1(prostate)	TOX2	77	0	239	20	0.0772200772200772	TRUE	TRUE
ENSG00000100109.17	.	BCM	GRCh38.p13	chr22	26499235	26499235	+	A	A	G	Missense_Mutation	SNP	ENST00000407690.6	exon9	c.T1198C	p.C400R	exonic	ENSG00000100109.17	.	nonsynonymous SNV	ENSG00000100109.17:ENST00000407690.6:exon9:c.T1198C:p.C400R	22q12.1	C3L-00599	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.928	T	T	D	0.524	0.847	0.851	1.599	T	T	D	D	D	D	4.192	28.600	0.996	D	D	0.636	6.312	0.571	5.876	1.000	0.722	0.702	0.702	0.735	.	5.670	4.620	6.529	1.312	0.756	1.000	0.865	0.542	978	GC-rich_sequence_DNA-binding_factor-like_domain	.	.	.	TFIP11	62	0	119	9	0.0703125	TRUE	TRUE
ENSG00000158578.21	.	BCM	GRCh38.p13	chrX	55009229	55009229	+	C	C	T	Missense_Mutation	SNP	ENST00000650242.1	exon11	c.G1715A	p.R572H	exonic	ENSG00000158578.21	.	nonsynonymous SNV	ENSG00000158578.21:ENST00000650242.1:exon11:c.G1715A:p.R572H	Xp11.21	C3L-00599	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	N	D	L	D	N	0.783	D	D	D	0.699	0.288	0.994	1.470	T	T	D	D	D	D	3.604	25.100	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.390	4.530	4.937	1.026	0.599	1.000	1.000	0.992	106	.	.	.	.	ALAS2	82	0	175	19	0.0979381443298969	TRUE	TRUE
ENSG00000171603.18	.	BCM	GRCh38.p13	chr1	9744438	9744438	+	G	G	A	Silent	SNP	ENST00000377298.9	exon8	c.C1191T	p.F397F	exonic	ENSG00000171603.18	.	synonymous SNV	ENSG00000171603.18:ENST00000377298.9:exon8:c.C1191T:p.F397F	1p36.22	C3L-00599	1.654e-05	0	0	0	0	3.009e-05	0	0	rs764400696	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLSTN1	181	0	260	15	0.0545454545454545	TRUE	NA
ENSG00000154007.7	.	BCM	GRCh38.p13	chr1	75919030	75919030	+	G	G	A	Silent	SNP	ENST00000284142.7	exon3	c.C810T	p.T270T	exonic	ENSG00000154007.7	.	synonymous SNV	ENSG00000154007.7:ENST00000284142.7:exon3:c.C810T:p.T270T	1p31.1	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ASB17	189	1	266	25	0.0859106529209622	TRUE	TRUE
ENSG00000135638.14	.	BCM	GRCh38.p13	chr2	72918203	72918203	+	C	C	T	Silent	SNP	ENST00000258106.11	exon1	c.C351T	p.L117L	exonic	ENSG00000135638.14	.	synonymous SNV	ENSG00000135638.14:ENST00000258106.11:exon1:c.C351T:p.L117L	2p13.2	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EMX1	107	0	225	13	0.0546218487394958	TRUE	TRUE
ENSG00000169836.5	.	BCM	GRCh38.p13	chr4	103656302	103656302	+	C	C	T	Silent	SNP	ENST00000304883.3	exon3	c.G780A	p.L260L	exonic	ENSG00000169836.5	.	synonymous SNV	ENSG00000169836.5:ENST00000304883.3:exon3:c.G780A:p.L260L	4q24	C3L-00599	8.255e-06	0	0	0.0001	0	0	0	0	rs768209062	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TACR3	305	1	471	45	0.0872093023255814	TRUE	NA
ENSG00000137312.15	.	BCM	GRCh38.p13	chr6	30740502	30740502	+	C	C	T	Silent	SNP	ENST00000376389.8	exon7	c.G564A	p.G188G	exonic	ENSG00000137312.15	.	synonymous SNV	ENSG00000137312.15:ENST00000376389.8:exon7:c.G564A:p.G188G	6p21.33	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FLOT1	187	0	345	26	0.0700808625336927	TRUE	TRUE
ENSG00000147912.13	.	BCM	GRCh38.p13	chr9	37516074	37516074	+	G	G	A	Silent	SNP	ENST00000432825.7	exon10	c.C2526T	p.N842N	exonic	ENSG00000147912.13	.	synonymous SNV	ENSG00000147912.13:ENST00000432825.7:exon10:c.C2526T:p.N842N	9p13.2	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBXO10	85	0	142	19	0.118012422360248	TRUE	TRUE
ENSG00000165204.3	.	BCM	GRCh38.p13	chr9	122800923	122800923	+	C	C	T	Silent	SNP	ENST00000277309.3	exon1	c.C801T	p.R267R	exonic	ENSG00000165204.3	.	synonymous SNV	ENSG00000165204.3:ENST00000277309.3:exon1:c.C801T:p.R267R	9q33.2	C3L-00599	3.323e-05	0	0	0	0	0	0	0.0002	rs773435922	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR1K1	178	0	384	21	0.0518518518518519	TRUE	NA
ENSG00000170370.12	.	BCM	GRCh38.p13	chr10	117548154	117548154	+	G	G	T	Silent	SNP	ENST00000553456.5	exon3	c.G681T	p.G227G	exonic	ENSG00000170370.12	.	synonymous SNV	ENSG00000170370.12:ENST00000553456.5:exon3:c.G681T:p.G227G	10q26.11	C3L-00599	.	.	.	.	.	.	.	.	.	3.11	.	D	.	.	.	D	.	.	.	0.412	T	T	T	0.062	-	0.756	.	.	.	T	T	T	T	1.158	13.290	0.990	D	N	0.241	3.487	0.335	3.930	1.000	0.598	0.596	0.615	0.530	.	5.240	5.240	1.976	1.176	0.665	1.000	1.000	0.998	752	.	.	.	ID=COSV101463626;OCCURENCE=1(lung)	EMX2	477	0	776	91	0.104959630911188	TRUE	TRUE
ENSG00000002016.18	.	BCM	GRCh38.p13	chr12	916659	916659	+	C	C	T	Silent	SNP	ENST00000358495.8	exon8	c.G705A	p.A235A	exonic	ENSG00000002016.18	.	synonymous SNV	ENSG00000002016.18:ENST00000358495.8:exon8:c.G705A:p.A235A	12p13.33	C3L-00599	3.424e-05	0	0	0	0	4.648e-05	0	6.174e-05	rs367718256	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAD52	110	0	210	13	0.0582959641255605	TRUE	NA
ENSG00000179284.5	.	BCM	GRCh38.p13	chr19	12969798	12969798	+	G	G	T	Silent	SNP	ENST00000317060.3	exon1	c.G138T	p.G46G	exonic	ENSG00000179284.5	.	synonymous SNV	ENSG00000179284.5:ENST00000317060.3:exon1:c.G138T:p.G46G	19p13.13	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DAND5	61	0	120	13	0.0977443609022556	TRUE	TRUE
ENSG00000187187.14	.	BCM	GRCh38.p13	chr19	40013768	40013768	+	C	C	T	Silent	SNP	ENST00000347077.9	exon7	c.C498T	p.I166I	exonic	ENSG00000187187.14	.	synonymous SNV	ENSG00000187187.14:ENST00000347077.9:exon7:c.C498T:p.I166I	19q13.2	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF546	84	0	182	20	0.099009900990099	TRUE	TRUE
ENSG00000218891.5	.	BCM	GRCh38.p13	chr19	55578524	55578524	+	G	G	A	Silent	SNP	ENST00000325421.7	exon2	c.C1116T	p.A372A	exonic	ENSG00000218891.5	.	synonymous SNV	ENSG00000218891.5:ENST00000325421.7:exon2:c.C1116T:p.A372A	19q13.42	C3L-00599	0	0	0	0	0	0	0	0	rs538352819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF579	27	0	118	8	0.0634920634920635	TRUE	NA
ENSG00000088827.12	.	BCM	GRCh38.p13	chr20	3699389	3699389	+	G	G	A	Silent	SNP	ENST00000344754.5	exon7	c.C1599T	p.S533S	exonic	ENSG00000088827.12	.	synonymous SNV	ENSG00000088827.12:ENST00000344754.5:exon7:c.C1599T:p.S533S	20p13	C3L-00599	4.568e-05	0	0	0	0	5.992e-05	0	8.126e-05	rs745634651	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99165570;OCCURENCE=1(stomach),1(endometrium)	SIGLEC1	332	0	655	182	0.217443249701314	TRUE	NA
ENSG00000147059.8	.	BCM	GRCh38.p13	chrX	57135977	57135977	+	A	A	G	Silent	SNP	ENST00000374908.1	exon1	c.T621C	p.D207D	exonic	ENSG00000147059.8	.	synonymous SNV	ENSG00000147059.8:ENST00000374908.1:exon1:c.T621C:p.D207D	Xp11.21	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPIN2A	94	0	150	41	0.214659685863874	NA	TRUE
ENSG00000231482.3	.	BCM	GRCh38.p13	chr2	1540908	1540908	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000231482.3	.	.	.	2p25.3	C3L-00599	.	.	.	.	.	.	.	.	.	1.12	D	.	.	.	.	N	.	T	N	.	T	T	.	0.019	0.256	0.507	.	.	.	T	T	T	T	0.358	4.961	0.444	N	N	-0.530	1.119	-0.716	0.876	0.999	0.581	0.574	0.576	0.613	.	1.380	1.380	0.969	0.760	0.440	0.179	0.016	0.011	934	.	.	.	.	AC105450.1	84	0	131	23	0.149350649350649	TRUE	TRUE
ENSG00000104518.11	.	BCM	GRCh38.p13	chr8	143560980	143560980	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000104518.11	.	.	.	8q24.3	C3L-00599	8.771e-06	0	0	0	0	0	0	6.192e-05	rs780783370	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52796670;OCCURENCE=1(large_intestine)	GSDMD	205	0	455	55	0.107843137254902	TRUE	NA
ENSG00000041982.16	.	BCM	GRCh38.p13	chr9	115053002	115053002	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000041982.16	.	.	.	9q33.1	C3L-00599	.	.	.	.	.	.	.	.	.	3.14	T	T	.	.	.	D	.	T	N	0.281	T	T	T	0.042	0.516	0.334	.	.	.	T	T	T	T	1.861	18.190	0.976	D	D	0.217	3.379	0.271	3.555	1.000	0.487	0.563	0.574	0.564	.	5.870	4.010	2.637	1.026	0.599	1.000	0.983	0.929	552	Fibronectin_type_III	.	.	.	TNC	101	0	197	32	0.139737991266376	TRUE	TRUE
ENSG00000284108.1	.	BCM	GRCh38.p13	chr11	61792533	61792533	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000284108.1	.	.	.	11q12.2	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR611	227	0	491	47	0.087360594795539	TRUE	NA
ENSG00000239438.1	.	BCM	GRCh38.p13	chr14	78243356	78243356	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000239438.1;ENSG00000258723.1	dist=11737;dist=36216	.	.	14q24.3	C3L-00599	7.917e-05	0	0	0	0	0	0	0.0003	rs368733653	4.7	.	D	.	.	.	.	.	.	.	0.256	T	T	.	0.106	.	.	.	.	T	.	.	.	D	3.272	24.000	0.998	D	D	0.406	4.379	0.505	5.201	0.996	0.638	0.590	0.653	0.564	.	6.160	5.270	3.946	1.176	0.676	1.000	0.998	0.986	555	Laminin_G_domain	.	.	.	RPS26P48	86	0	207	12	0.0547945205479452	TRUE	NA
ENSG00000221525.1	.	BCM	GRCh38.p13	chr14	101043045	101043045	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000221525.1	.	.	.	14q32.31	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR1185-1	163	0	150	35	0.189189189189189	TRUE	NA
ENSG00000165246.14	.	BCM	GRCh38.p13	chrY	14524716	14524716	+	C	C	G	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000165246.14	ENST00000339174.9:c.-97404C>G	.	.	Yq11.221	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NLGN4Y	272	0	347	89	0.204128440366972	TRUE	NA
ENSG00000178226.11	.	BCM	GRCh38.p13	chr16	31139215	31139216	+	GG	GG	CA	Unknown	MNP	ENST00000268281.9	exon15	c.2490_2491delinsTG	p.P831A	exonic	ENSG00000178226.11	.	nonframeshift substitution	ENSG00000178226.11:ENST00000268281.9:exon15:c.2490_2491delinsTG:p.P831A	16p11.2	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRSS36	90	0	175	5	0.0277777777777778	TRUE	NA
ENSG00000141736.13	.	BCM	GRCh38.p13	chr17	39711955	39711956	+	CC	CC	AT	Unknown	MNP	ENST00000269571.9	exon8	c.929_930delinsAT	p.S310Y	exonic	ENSG00000141736.13	.	nonframeshift substitution	ENSG00000141736.13:ENST00000269571.9:exon8:c.929_930delinsAT:p.S310Y	17q12	C3L-00599	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54073235;OCCURENCE=1(NS),1(endometrium)	ERBB2	276	0	515	38	0.0687160940325497	TRUE	NA
ENSG00000092853.14	.	BCM	GRCh38.p13	chr1	35762000	35762000	+	C	C	T	Missense_Mutation	SNP	ENST00000318121.8	exon6	c.G893A	p.R298Q	exonic	ENSG00000092853.14	.	nonsynonymous SNV	ENSG00000092853.14:ENST00000318121.8:exon6:c.G893A:p.R298Q	1p34.3	C3L-01051	0.0003	0	0	0.0039	0	0	0	6.196e-05	rs115197921	13.20	D	D	D	D	D	D	M	T	D	0.935	T	T	D	0.389	.	0.857	0.497	T	T	T	D	T	D	4.449	32	1.000	D	D	0.794	8.656	0.767	9.225	1.000	0.731	0.723	0.725	0.649	.	5.390	5.390	5.686	1.026	0.549	1.000	0.999	0.960	199	.	.	.	ID=COSV52053868;OCCURENCE=1(large_intestine),1(upper_aerodigestive_tract)	CLSPN	265	0	205	30	0.127659574468085	TRUE	TRUE
ENSG00000170989.10	.	BCM	GRCh38.p13	chr1	101239855	101239855	+	T	T	C	Missense_Mutation	SNP	ENST00000305352.7	exon2	c.T871C	p.F291L	exonic	ENSG00000170989.10	.	nonsynonymous SNV	ENSG00000170989.10:ENST00000305352.7:exon2:c.T871C:p.F291L	1p21.2	C3L-01051	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	L	T	D	0.142	T	T	T	0.110	0.414	0.549	1.213	T	T	T	T	D	T	3.013	23.400	0.968	D	D	-0.125	2.097	0.060	2.575	1.000	0.714	0.672	0.609	0.617	.	5.130	5.130	6.268	1.138	0.609	1.000	0.763	0.960	708	GPCR,_rhodopsin-like,_7TM	.	.	.	S1PR1	332	1	560	58	0.0938511326860841	TRUE	TRUE
ENSG00000179639.10	.	BCM	GRCh38.p13	chr1	159303986	159303986	+	G	G	T	Missense_Mutation	SNP	ENST00000368115.5	exon4	c.G135T	p.E45D	exonic	ENSG00000179639.10	.	nonsynonymous SNV	ENSG00000179639.10:ENST00000368115.5:exon4:c.G135T:p.E45D	1q23.2	C3L-01051	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.085	T	T	T	0.125	0.821	0.273	0.030	T	T	T	T	T	T	-0.620	0.066	0.095	N	N	-1.538	0.070	-1.547	0.091	0.026	0.554	0.588	0.574	0.564	.	4.700	-3.990	-1.977	-0.218	-0.244	0.000	0.361	0.892	785	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV63668419;OCCURENCE=1(endometrium)	FCER1A	325	0	326	37	0.101928374655647	TRUE	TRUE
ENSG00000116127.18	.	BCM	GRCh38.p13	chr2	73452010	73452010	+	T	T	A	Nonsense_Mutation	SNP	ENST00000613296.5	exon8	c.T5483A	p.L1828X	exonic	ENSG00000116127.18	.	stopgain	ENSG00000116127.18:ENST00000613296.5:exon8:c.T5483A:p.L1828X	2p13.1	C3L-01051	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	D	A	.	.	.	0.799	.	.	.	.	.	.	.	.	.	D	D	.	.	5.803	35	0.969	N	N	-0.019	2.446	-0.370	1.428	1.000	0.707	0.686	0.725	0.684	.	4.240	1.890	0.998	1.138	0.665	0.008	0.002	0.384	492	.	.	.	.	ALMS1	416	0	485	40	0.0761904761904762	TRUE	TRUE
ENSG00000239305.7	.	BCM	GRCh38.p13	chr2	86604132	86604132	+	C	C	T	Missense_Mutation	SNP	ENST00000237455.5	exon4	c.G1769A	p.R590K	exonic	ENSG00000239305.7	.	nonsynonymous SNV	ENSG00000239305.7:ENST00000237455.5:exon4:c.G1769A:p.R590K	2p11.2	C3L-01051	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	D	L	T	N	0.078	T	T	T	0.144	0.336	0.280	0.224	T	T	T	T	T	T	1.101	12.780	0.910	N	N	-0.810	0.640	-0.775	0.793	0.521	0.706	0.725	0.710	0.714	.	5.510	4.630	0.810	0.121	0.549	0.001	0.619	0.741	603	.	.	.	ID=COSV52893523;OCCURENCE=1(thymus)	RNF103	400	1	436	29	0.0623655913978495	TRUE	TRUE
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140716036	140716036	+	C	C	T	Missense_Mutation	SNP	ENST00000389484.8	exon37	c.G5960A	p.R1987H	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon37:c.G5960A:p.R1987H	2q22.1	C3L-01051	3.306e-05	0	0	0	0	6.008e-05	0	0	rs202025670	18.20	D	D	D	D	U	D	M	D	D	0.939	D	D	D	0.946	0.807	0.814	0.694	T	D	D	D	D	D	4.089	27.700	0.999	D	D	0.873	10.385	0.822	10.799	1.000	0.487	0.574	0.574	0.564	.	5.130	5.130	7.858	1.026	0.599	1.000	1.000	0.999	944	.	.	.	.	LRP1B	148	0	129	17	0.116438356164384	TRUE	NA
ENSG00000144285.21	.	BCM	GRCh38.p13	chr2	166041268	166041268	+	G	G	A	Missense_Mutation	SNP	ENST00000303395.8	exon15	c.C2378T	p.T793M	exonic	ENSG00000144285.21	.	nonsynonymous SNV	ENSG00000144285.21:ENST00000303395.8:exon15:c.C2378T:p.T793M	2q24.3	C3L-01051	8.241e-05	0	8.643e-05	0.0008	0	2.998e-05	0	0	rs762038032	18.20	D	D	D	D	D	D	M	D	D	0.527	D	D	D	0.724	0.350	0.983	1.720	T	D	T	D	D	D	3.498	24.700	0.999	D	D	0.774	8.291	0.730	8.358	0.363	0.554	0.574	0.602	0.564	.	5.540	5.540	5.173	1.176	0.618	1.000	0.790	0.919	497	Ion_transport_domain	.	.	ID=COSV100321456;OCCURENCE=1(stomach)	SCN1A	291	0	228	40	0.149253731343284	TRUE	NA
ENSG00000138449.11	.	BCM	GRCh38.p13	chr2	189571757	189571757	+	A	A	C	Missense_Mutation	SNP	ENST00000261024.7	exon5	c.T472G	p.W158G	exonic	ENSG00000138449.11	.	nonsynonymous SNV	ENSG00000138449.11:ENST00000261024.7:exon5:c.T472G:p.W158G	2q32.2	C3L-01051	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.921	D	D	D	0.977	0.875	0.939	1.817	T	D	D	D	D	D	4.542	32	0.979	D	D	0.891	10.818	0.845	11.605	1.000	0.706	0.574	0.590	0.613	.	5.290	5.290	9.114	1.312	0.756	1.000	0.980	0.998	779	.	.	.	.	SLC40A1	412	0	388	57	0.128089887640449	TRUE	TRUE
ENSG00000144481.17	.	BCM	GRCh38.p13	chr2	233969705	233969705	+	C	C	T	Missense_Mutation	SNP	ENST00000324695.9	exon16	c.C2036T	p.S679F	exonic	ENSG00000144481.17	.	nonsynonymous SNV	ENSG00000144481.17:ENST00000324695.9:exon16:c.C2036T:p.S679F	2q37.1	C3L-01051	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.781	D	D	D	0.877	0.473	0.998	0.698	D	D	D	D	D	D	4.127	28.000	0.998	D	D	0.779	8.388	0.759	9.011	1.000	0.487	0.574	0.547	0.564	.	5.420	5.420	5.841	1.022	0.596	1.000	0.999	0.998	929	.	.	.	.	TRPM8	294	0	263	54	0.170347003154574	TRUE	NA
ENSG00000163378.14	.	BCM	GRCh38.p13	chr3	68988951	68988951	+	G	G	A	Missense_Mutation	SNP	ENST00000383701.8	exon11	c.C898T	p.H300Y	exonic	ENSG00000163378.14	.	nonsynonymous SNV	ENSG00000163378.14:ENST00000383701.8:exon11:c.C898T:p.H300Y	3p14.1	C3L-01051	.	.	.	.	.	.	.	.	.	7.19	T	T	B	B	D	D	M	T	N	0.591	T	T	D	0.201	0.574	0.283	.	.	T	T	T	D	T	2.793	23.000	0.992	D	D	0.131	3.011	0.331	3.900	1.000	0.745	0.602	0.744	0.762	.	5.720	5.720	9.455	1.146	0.618	1.000	0.998	0.964	645	.	.	.	.	EOGT	201	0	130	27	0.171974522292994	TRUE	TRUE
ENSG00000181722.16	.	BCM	GRCh38.p13	chr3	114339367	114339367	+	T	T	C	Missense_Mutation	SNP	ENST00000474710.5	exon5	c.A1864G	p.I622V	exonic	ENSG00000181722.16	.	nonsynonymous SNV	ENSG00000181722.16:ENST00000474710.5:exon5:c.A1864G:p.I622V	3q13.31	C3L-01051	.	.	.	.	.	.	.	.	.	8.20	D	D	P	P	D	D	N	T	N	0.461	T	T	T	0.224	0.458	0.313	1.905	D	T	T	T	D	T	3.124	23.700	0.995	D	D	0.461	4.748	0.572	5.889	1.000	0.563	0.654	0.602	0.492	.	6.170	6.170	6.167	1.138	0.665	1.000	1.000	0.998	840	Zinc_finger_C2H2-type	.	.	.	ZBTB20	297	0	442	86	0.162878787878788	TRUE	TRUE
ENSG00000169704.4	.	BCM	GRCh38.p13	chr3	129061900	129061900	+	G	G	A	Missense_Mutation	SNP	ENST00000307395.4	exon3	c.G161A	p.R54H	exonic	ENSG00000169704.4	.	nonsynonymous SNV	ENSG00000169704.4:ENST00000307395.4:exon3:c.G161A:p.R54H	3q21.3	C3L-01051	8.725e-06	0	0	0	0	0	0	6.174e-05	rs763418097	7.20	D	D	D	D	U	N	L	T	N	0.447	T	T	D	0.238	0.457	0.582	0.769	T	T	T	T	D	D	3.441	24.500	0.999	N	N	0.061	2.733	-0.072	2.130	0.944	0.497	0.590	0.578	0.613	.	4.170	4.170	1.079	1.121	0.676	0.015	0.959	0.202	654	Leucine-rich_repeat_N-terminal_domain	.	.	ID=COSV56624094;OCCURENCE=1(lung)	GP9	628	0	1358	122	0.0824324324324324	TRUE	TRUE
ENSG00000171757.17	.	BCM	GRCh38.p13	chr3	169795603	169795603	+	A	A	G	Missense_Mutation	SNP	ENST00000446859.7	exon10	c.T1073C	p.V358A	exonic	ENSG00000171757.17	.	nonsynonymous SNV	ENSG00000171757.17:ENST00000446859.7:exon10:c.T1073C:p.V358A	3q26.2	C3L-01051	5.021e-05	0	0	0	0.0006	1.526e-05	0.0011	0	rs543612719	8.18	D	D	P	P	D	D	.	T	D	0.837	T	T	T	0.346	.	0.670	0.372	T	.	T	T	D	T	3.571	24.900	0.999	D	D	0.527	5.250	0.506	5.218	0.999	0.638	0.670	0.618	0.568	.	5.190	5.190	5.941	1.288	0.691	0.924	0.971	0.782	469	.	.	.	.	LRRC34	143	0	93	48	0.340425531914894	TRUE	NA
ENSG00000186001.14	.	BCM	GRCh38.p13	chr3	197870242	197870244	+	AGA	AGA	-	In_Frame_Del	DEL	ENST00000425562.7	exon18	c.1956_1958del	p.E655del	exonic	ENSG00000186001.14	.	nonframeshift deletion	ENSG00000186001.14:ENST00000425562.7:exon18:c.1956_1958del:p.E655del	3q29	C3L-01051	2.471e-05	0	0	0.0001	0	1.499e-05	0	6.058e-05	rs759920668	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRCH3	288	0	257	76	0.228228228228228	TRUE	TRUE
ENSG00000145451.13	.	BCM	GRCh38.p13	chr4	174677269	174677269	+	G	G	A	Nonsense_Mutation	SNP	ENST00000274093.8	exon7	c.C736T	p.R246X	exonic	ENSG00000145451.13	.	stopgain	ENSG00000145451.13:ENST00000274093.8:exon7:c.C736T:p.R246X	4q34.1	C3L-01051	1.665e-05	9.662e-05	0	0	0	1.513e-05	0	0	rs201620617	5.6	.	.	.	.	D	A	.	.	.	0.634	.	.	.	.	.	.	.	.	.	D	D	.	.	6.442	36	0.996	D	N	0.252	3.542	0.064	2.592	0.002	0.487	0.574	0.574	0.564	.	5.560	2.850	0.599	-0.140	-0.106	0.324	0.998	0.991	963	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	ID=COSV56859263;OCCURENCE=1(large_intestine),2(stomach)	GLRA3	131	0	153	23	0.130681818181818	TRUE	TRUE
ENSG00000164253.14	.	BCM	GRCh38.p13	chr5	77464805	77464805	+	C	C	T	Missense_Mutation	SNP	ENST00000296679.9	exon3	c.G172A	p.A58T	exonic	ENSG00000164253.14	.	nonsynonymous SNV	ENSG00000164253.14:ENST00000296679.9:exon3:c.G172A:p.A58T	5q13.3	C3L-01051	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.724	D	D	D	0.646	0.600	0.859	0.266	T	T	D	D	D	D	3.944	26.600	0.999	D	D	0.769	8.199	0.744	8.651	1.000	0.732	0.663	0.659	0.728	.	5.530	5.530	5.208	1.026	0.599	1.000	1.000	0.993	686	WD40-repeat-containing_domain	.	.	.	WDR41	285	0	327	40	0.108991825613079	TRUE	TRUE
ENSG00000164402.14	.	BCM	GRCh38.p13	chr5	132762605	132762605	+	G	G	A	Missense_Mutation	SNP	ENST00000378719.7	exon5	c.C575T	p.S192F	exonic	ENSG00000164402.14	.	nonsynonymous SNV	ENSG00000164402.14:ENST00000378719.7:exon5:c.C575T:p.S192F	5q31.1	C3L-01051	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.907	D	D	D	0.427	0.580	0.766	1.203	D	D	D	D	D	D	4.142	28.100	0.998	D	D	1.010	14.240	0.950	16.084	1.000	0.706	0.725	0.710	0.714	.	5.980	5.980	6.817	1.176	0.618	1.000	1.000	0.987	898	Septin-type_guanine_nucleotide-binding_(G)_domain	.	.	.	SEPTIN8	270	0	456	61	0.117988394584139	TRUE	TRUE
ENSG00000145934.16	.	BCM	GRCh38.p13	chr5	168228075	168228075	+	G	G	A	Missense_Mutation	SNP	ENST00000518659.5	exon25	c.G5465A	p.R1822H	exonic	ENSG00000145934.16	.	nonsynonymous SNV	ENSG00000145934.16:ENST00000518659.5:exon25:c.G5465A:p.R1822H	5q34	C3L-01051	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.889	D	D	D	0.838	0.583	0.895	1.389	D	T	D	D	D	D	4.433	31	0.999	D	D	0.968	12.948	0.938	15.480	1.000	0.615	0.166	0.659	0.635	.	5.660	5.660	9.964	1.176	0.676	1.000	0.998	0.995	917	.	.	.	ID=COSV69124662;OCCURENCE=1(large_intestine),1(pancreas)	TENM2	319	0	552	90	0.14018691588785	TRUE	TRUE
ENSG00000095970.17	.	BCM	GRCh38.p13	chr6	41158768	41158768	+	G	G	A	Missense_Mutation	SNP	ENST00000373113.8	exon5	c.C689T	p.T230M	exonic	ENSG00000095970.17	.	nonsynonymous SNV	ENSG00000095970.17:ENST00000373113.8:exon5:c.C689T:p.T230M	6p21.1	C3L-01051	4.119e-05	0	0	0	0	1.498e-05	0	0.0002	rs368921728	2.19	D	D	B	B	N	N	.	T	N	0.093	T	T	T	0.023	.	0.153	0.294	T	T	T	T	T	T	1.460	15.480	0.957	N	N	-0.954	0.455	-1.050	0.430	0.997	0.554	0.590	0.618	0.564	.	4.360	-1.960	-0.099	-0.136	0.665	0.000	0.003	0.101	674	.	.	.	.	TREM2	761	0	1094	265	0.194996320824135	TRUE	NA
ENSG00000146216.13	.	BCM	GRCh38.p13	chr6	43263156	43263156	+	C	C	T	Missense_Mutation	SNP	ENST00000259750.9	exon13	c.C1792T	p.R598C	exonic	ENSG00000146216.13	.	nonsynonymous SNV	ENSG00000146216.13:ENST00000259750.9:exon13:c.C1792T:p.R598C	6p21.1	C3L-01051	3.717e-05	0	0	0	0	7.438e-05	0	0	rs374064146	10.20	D	T	D	D	D	D	M	T	N	0.627	T	T	D	0.190	.	0.159	1.208	T	T	T	T	D	D	4.057	27.400	0.999	D	N	0.547	5.425	0.525	5.398	1.000	0.581	0.547	0.576	0.563	.	5.290	4.360	3.514	0.120	-0.176	1.000	0.966	0.985	184	.	.	.	.	TTBK1	107	0	464	38	0.0756972111553785	TRUE	NA
ENSG00000171453.20	.	BCM	GRCh38.p13	chr6	43517134	43517134	+	G	G	A	Missense_Mutation	SNP	ENST00000642195.1	exon1	c.G25A	p.E9K	exonic	ENSG00000171453.20	.	nonsynonymous SNV	ENSG00000171453.20:ENST00000642195.1:exon1:c.G25A:p.E9K	6p21.1	C3L-01051	.	.	.	.	.	.	.	.	.	11.20	T	T	B	B	D	D	M	D	N	0.664	T	T	D	0.486	0.334	0.846	0.095	T	T	D	D	D	D	2.658	22.700	0.997	D	D	0.352	4.060	0.373	4.172	1.000	0.442	0.522	0.522	0.562	.	5.230	5.230	8.320	1.176	0.676	1.000	0.076	0.229	217	.	.	.	.	POLR1C	491	0	1627	779	0.323773898586866	TRUE	TRUE
ENSG00000180113.16	.	BCM	GRCh38.p13	chr6	46688636	46688636	+	G	G	A	Missense_Mutation	SNP	ENST00000316081.11	exon1	c.G508A	p.V170I	exonic	ENSG00000180113.16	.	nonsynonymous SNV	ENSG00000180113.16:ENST00000316081.11:exon1:c.G508A:p.V170I	6p12.3	C3L-01051	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	N	0.245	T	T	D	0.218	0.431	0.342	0.105	T	T	T	T	D	T	2.952	23.300	0.998	D	D	0.627	6.205	0.580	5.977	1.000	0.517	0.574	0.479	0.542	.	5.470	5.470	6.416	1.101	0.590	1.000	0.994	0.978	505	.	.	.	ID=COSV60174750;OCCURENCE=1(large_intestine),2(stomach)	TDRD6	217	0	533	94	0.149920255183413	TRUE	TRUE
ENSG00000075618.18	.	BCM	GRCh38.p13	chr7	5603377	5603377	+	C	C	T	Missense_Mutation	SNP	ENST00000382361.8	exon2	c.C953T	p.T318M	exonic	ENSG00000075618.18	.	nonsynonymous SNV	ENSG00000075618.18:ENST00000382361.8:exon2:c.C953T:p.T318M	7p22.1	C3L-01051	7.479e-05	0	0.0004	0.0003	0	1.517e-05	0	0	rs150576558	10.20	D	D	D	D	D	D	M	T	N	0.745	T	T	D	0.240	.	0.500	1.254	T	T	T	T	T	T	3.879	26.200	0.999	D	D	0.619	6.122	0.564	5.800	1.000	0.672	0.698	0.698	0.711	.	4.750	4.750	5.020	-0.256	0.599	1.000	0.428	0.949	929	Fascin_domain	.	.	.	FSCN1	335	0	611	109	0.151388888888889	TRUE	NA
ENSG00000055609.18	.	BCM	GRCh38.p13	chr7	152148728	152148728	+	C	C	T	Missense_Mutation	SNP	ENST00000262189.11	exon52	c.G13199A	p.R4400Q	exonic	ENSG00000055609.18	.	nonsynonymous SNV	ENSG00000055609.18:ENST00000262189.11:exon52:c.G13199A:p.R4400Q	7q36.1	C3L-01051	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	U	D	M	D	D	0.840	D	D	D	0.830	0.579	0.955	1.388	T	D	D	D	D	D	4.067	27.500	0.998	D	D	0.758	8.021	0.691	7.585	1.000	0.707	0.725	0.725	0.714	.	5.240	5.240	7.905	1.026	0.599	1.000	0.998	0.999	789	Extended_PHD_(ePHD)_domain	.	.	ID=COSV51466658;OCCURENCE=2(breast),2(large_intestine)	KMT2C	413	0	537	99	0.155660377358491	TRUE	TRUE
ENSG00000198010.12	.	BCM	GRCh38.p13	chr8	1668602	1668602	+	G	G	T	Missense_Mutation	SNP	ENST00000421627.7	exon9	c.G2081T	p.R694L	exonic	ENSG00000198010.12	.	nonsynonymous SNV	ENSG00000198010.12:ENST00000421627.7:exon9:c.G2081T:p.R694L	8p23.3	C3L-01051	.	.	.	.	.	.	.	.	.	2.17	.	T	B	B	N	N	L	.	.	0.297	T	T	T	0.074	0.377	0.143	0.126	T	T	T	T	T	D	2.499	22.400	0.938	D	N	-0.357	1.480	-0.275	1.617	0.996	0.487	0.574	0.000	0.564	.	5.010	5.010	3.568	1.121	0.676	0.998	0.207	0.366	964	.	.	.	.	DLGAP2	209	0	344	77	0.182897862232779	TRUE	TRUE
ENSG00000158669.11	.	BCM	GRCh38.p13	chr8	41612180	41612180	+	G	G	C	Missense_Mutation	SNP	ENST00000396987.7	exon7	c.G702C	p.R234S	exonic	ENSG00000158669.11	.	nonsynonymous SNV	ENSG00000158669.11:ENST00000396987.7:exon7:c.G702C:p.R234S	8p11.21	C3L-01051	.	.	.	.	.	.	.	.	.	12.20	T	T	B	B	D	D	M	D	N	0.302	D	D	D	0.348	0.330	0.920	1.147	T	D	D	T	D	T	3.138	23.700	0.982	D	D	-0.017	2.453	0.108	2.768	1.000	0.707	0.725	0.725	0.714	.	5.270	4.400	1.918	1.176	0.676	1.000	0.993	0.980	760	Phospholipid/glycerol_acyltransferase	.	.	.	GPAT4	185	0	228	96	0.296296296296296	TRUE	TRUE
ENSG00000121005.9	.	BCM	GRCh38.p13	chr8	75029429	75029429	+	C	C	T	Nonsense_Mutation	SNP	ENST00000262207.9	exon14	c.C1363T	p.R455X	exonic	ENSG00000121005.9	.	stopgain	ENSG00000121005.9:ENST00000262207.9:exon14:c.C1363T:p.R455X	8q21.13	C3L-01051	.	.	.	.	.	.	.	.	rs149361480	4.6	.	.	.	.	N	A	.	.	.	0.451	.	.	.	.	.	.	.	.	.	D	D	.	.	7.468	38	0.997	D	N	0.850	9.843	0.715	8.041	0.015	0.693	0.574	0.659	0.668	.	5.290	5.290	2.061	1.026	0.599	0.998	0.998	0.933	886	LCCL_domain	.	.	ID=COSV51546711;OCCURENCE=1(kidney),2(skin)	CRISPLD1	313	1	390	26	0.0625	TRUE	TRUE
ENSG00000104327.7	.	BCM	GRCh38.p13	chr8	90060643	90060643	+	C	C	T	Missense_Mutation	SNP	ENST00000265431.7	exon10	c.G658A	p.E220K	exonic	ENSG00000104327.7	.	nonsynonymous SNV	ENSG00000104327.7:ENST00000265431.7:exon10:c.G658A:p.E220K	8q21.3	C3L-01051	1.648e-05	0	0.0002	0	0	0	0	0	rs761899367	16.20	D	D	P	P	D	D	N	D	D	0.533	D	D	D	0.651	0.674	0.916	1.185	T	D	D	D	D	D	3.842	26.000	0.999	D	D	0.594	5.861	0.659	7.055	1.000	0.693	0.588	0.659	0.613	.	5.800	5.800	6.636	1.008	0.599	1.000	0.997	0.973	927	EF-hand_domain	.	.	.	CALB1	238	0	227	61	0.211805555555556	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21974781	21974781	+	-	NA	GT	Frame_Shift_Ins	INS	ENST00000304494.9	exon1	c.46_47insAC	p.L16Hfs*11	exonic	ENSG00000147889.17	.	frameshift insertion	ENSG00000147889.17:ENST00000304494.9:exon1:c.46_47insAC:p.L16Hfs*11	9p21.3	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	NA	NA	NA	NA	NA	NA	NA
ENSG00000119522.16	.	BCM	GRCh38.p13	chr9	123381647	123381647	+	C	C	T	Missense_Mutation	SNP	ENST00000373624.6	exon22	c.G2815A	p.G939R	exonic	ENSG00000119522.16	.	nonsynonymous SNV	ENSG00000119522.16:ENST00000373624.6:exon22:c.G2815A:p.G939R	9q33.3	C3L-01051	.	.	.	.	.	.	.	.	.	11.20	D	D	D	P	D	D	M	T	N	0.131	T	T	D	0.165	0.348	0.194	0.856	T	T	T	T	D	D	3.274	24.100	0.999	D	D	0.404	4.370	0.436	4.626	1.000	0.635	0.644	0.645	0.655	.	5.110	5.110	1.366	1.026	0.599	0.998	1.000	0.989	379	.	.	.	.	DENND1A	196	0	307	74	0.194225721784777	TRUE	NA
ENSG00000136895.19	.	BCM	GRCh38.p13	chr9	127318094	127318094	+	C	C	T	Missense_Mutation	SNP	ENST00000373387.9	exon5	c.C470T	p.P157L	exonic	ENSG00000136895.19	.	nonsynonymous SNV	ENSG00000136895.19:ENST00000373387.9:exon5:c.C470T:p.P157L	9q33.3	C3L-01051	.	.	.	.	.	.	.	.	.	18.20	D	D	D	P	D	D	M	D	D	0.714	D	D	D	0.696	0.418	0.871	0.602	D	T	D	D	D	D	3.782	25.800	0.991	D	D	0.735	7.634	0.761	9.053	1.000	0.615	0.624	0.659	0.568	.	5.870	5.870	6.652	1.026	0.599	1.000	1.000	0.998	599	.	.	.	.	GARNL3	410	0	386	45	0.104408352668213	TRUE	TRUE
ENSG00000156671.15	.	BCM	GRCh38.p13	chr10	75168626	75168626	+	G	G	A	Missense_Mutation	SNP	ENST00000542569.6	exon4	c.G760A	p.V254M	exonic	ENSG00000156671.15	.	nonsynonymous SNV	ENSG00000156671.15:ENST00000542569.6:exon4:c.G760A:p.V254M	10q22.2	C3L-01051	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.774	D	D	D	0.753	0.823	0.985	2.877	D	D	D	D	D	D	4.128	28.000	0.999	D	D	0.944	12.238	0.919	14.593	1.000	0.706	0.725	0.710	0.714	.	5.580	5.580	10.003	1.176	0.676	1.000	1.000	1.000	23	.	.	.	.	SAMD8	349	2	479	27	0.0533596837944664	TRUE	NA
ENSG00000099204.20	.	BCM	GRCh38.p13	chr10	114547744	114547744	+	C	C	G	Missense_Mutation	SNP	ENST00000277895.9	exon5	c.G706C	p.G236R	exonic	ENSG00000099204.20	.	nonsynonymous SNV	ENSG00000099204.20:ENST00000277895.9:exon5:c.G706C:p.G236R	10q25.3	C3L-01051	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	N	D	L	D	D	0.944	T	T	D	0.875	0.536	0.909	1.285	D	D	D	D	D	D	3.813	25.900	0.999	D	D	0.524	5.227	0.604	6.275	1.000	0.742	0.588	0.659	0.662	.	5.660	5.660	7.727	1.026	0.599	1.000	0.991	0.957	905	Zinc_finger,_LIM-type	.	.	.	ABLIM1	233	0	444	70	0.136186770428016	TRUE	NA
ENSG00000189057.11	.	BCM	GRCh38.p13	chr11	59126196	59126196	+	G	G	A	Missense_Mutation	SNP	ENST00000343597.4	exon4	c.G2099A	p.S700N	exonic	ENSG00000189057.11	.	nonsynonymous SNV	ENSG00000189057.11:ENST00000343597.4:exon4:c.G2099A:p.S700N	11q12.1	C3L-01051	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.039	T	T	T	0.012	0.129	0.198	0.050	T	T	T	T	T	T	-0.824	0.022	0.482	N	N	-1.552	0.067	-1.638	0.065	0.016	0.707	0.725	0.651	0.636	.	3.230	-4.110	-1.154	0.056	-0.259	0.000	0.014	0.001	626	.	.	.	.	FAM111B	157	0	95	9	0.0865384615384615	TRUE	TRUE
ENSG00000175513.9	.	BCM	GRCh38.p13	chr11	65948132	65948132	+	C	C	T	Nonsense_Mutation	SNP	ENST00000532620.5	exon4	c.C1135T	p.R379X	exonic	ENSG00000175513.9	.	stopgain	ENSG00000175513.9:ENST00000532620.5:exon4:c.C1135T:p.R379X	11q13.1	C3L-01051	6.758e-05	0.0002	0	0	0	0	0	0.0003	rs758452043	2.4	.	.	.	.	.	.	.	.	.	0.155	.	.	.	.	.	.	.	.	.	T	T	.	.	6.592	36	0.908	D	D	.	.	.	.	0.870	0.162	0.090	0.175	0.075	.	4.710	2.820	0.697	-0.265	-0.821	0.996	0.996	0.947	229	.	.	.	ID=COSV73245228;OCCURENCE=1(cervix),1(stomach),1(small_intestine)	TSGA10IP	168	0	248	30	0.107913669064748	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227342	25227342	+	T	T	A	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A182T	p.Q61L	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A182T:p.Q61L	12p12.1	C3L-01051	.	.	.	.	.	.	.	.	rs121913240	18.20	D	D	D	P	D	D	M	D	D	0.829	D	D	D	0.885	0.640	0.979	2.605	D	D	D	D	D	T	4.098	27.700	0.996	D	D	0.891	10.832	0.851	11.816	1.000	0.722	0.710	0.710	0.735	.	5.770	5.770	8.004	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55504296;OCCURENCE=1(salivary_gland),2(breast),64(large_intestine),1(central_nervous_system),6(biliary_tract),1(ovary),1(NS),2(stomach),6(haematopoietic_and_lymphoid_tissue),1(kidney),3(urinary_tract),1(soft_tissue),13(pancreas),7(skin),2(prostate),20(lung),3(thyroid),1(testis),1(small_intestine),4(endometrium)	KRAS	271	1	337	5	0.0146198830409357	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01051	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	435	0	426	76	0.151394422310757	TRUE	TRUE
ENSG00000173157.17	.	BCM	GRCh38.p13	chr12	43502256	43502256	+	T	T	G	Missense_Mutation	SNP	ENST00000389420.8	exon4	c.A763C	p.I255L	exonic	ENSG00000173157.17	.	nonsynonymous SNV	ENSG00000173157.17:ENST00000389420.8:exon4:c.A763C:p.I255L	12q12	C3L-01051	.	.	.	.	.	.	.	.	.	0.17	T	T	.	.	N	N	N	T	N	0.171	T	T	T	0.115	0.361	0.281	0.034	T	.	T	T	T	T	-0.565	0.087	0.502	N	N	-1.522	0.075	-1.371	0.167	0.007	0.487	0.574	0.574	0.564	.	4.660	-4.030	0.235	-0.464	-0.715	0.982	0.954	0.946	700	.	.	.	.	ADAMTS20	305	2	247	35	0.124113475177305	TRUE	TRUE
ENSG00000167548.15	.	BCM	GRCh38.p13	chr12	49049745	49049745	+	T	T	-	Frame_Shift_Del	DEL	ENST00000301067.11	exon11	c.3843delA	p.G1282Afs*48	exonic	ENSG00000167548.15	.	frameshift deletion	ENSG00000167548.15:ENST00000301067.11:exon11:c.3843delA:p.G1282Afs*48	12q13.12	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KMT2D	95	0	155	13	0.0773809523809524	NA	TRUE
ENSG00000179626.4	.	BCM	GRCh38.p13	chr12	55551357	55551357	+	T	T	C	Missense_Mutation	SNP	ENST00000641569.1	exon2	c.T131C	p.I44T	exonic	ENSG00000179626.4	.	nonsynonymous SNV	ENSG00000179626.4:ENST00000641569.1:exon2:c.T131C:p.I44T	12q13.2	C3L-01051	.	.	.	.	.	.	.	.	.	7.20	D	D	D	P	N	N	M	T	D	0.465	T	T	T	0.107	0.608	0.873	0.001	T	T	T	T	D	D	3.259	24.000	0.998	N	N	0.431	4.542	0.289	3.652	0.001	0.487	0.574	0.574	0.564	.	4.770	4.770	5.830	1.051	0.665	0.885	0.931	0.033	682	GPCR,_rhodopsin-like,_7TM	.	.	.	OR6C4	321	0	309	54	0.148760330578512	TRUE	TRUE
ENSG00000137877.10	.	BCM	GRCh38.p13	chr15	41869906	41869906	+	G	G	A	Nonsense_Mutation	SNP	ENST00000320955.8	exon32	c.C5788T	p.R1930X	exonic	ENSG00000137877.10	.	stopgain	ENSG00000137877.10:ENST00000320955.8:exon32:c.C5788T:p.R1930X	15q15.1	C3L-01051	3.355e-05	0	0	0	0	6.575e-05	0	0	rs771424817	3.6	.	.	.	.	N	A	.	.	.	0.190	.	.	.	.	.	.	.	.	.	D	D	.	.	5.678	34	0.991	N	N	0.025	2.601	-0.334	1.495	1.000	0.563	0.610	0.578	0.636	.	4.700	1.740	-0.019	1.175	0.675	0.000	0.005	0.017	197	.	.	.	.	SPTBN5	71	0	301	33	0.0988023952095808	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674242	7674242	+	A	A	G	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.T721C	p.S241P	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.T721C:p.S241P	17p13.1	C3L-01051	.	.	.	.	.	.	.	.	rs1057520002	19.20	D	D	D	D	D	D	M	D	D	0.929	D	D	D	0.954	0.967	0.989	0.429	T	D	D	D	D	D	4.092	27.700	0.998	D	D	0.568	5.615	0.450	4.732	0.000	0.722	0.702	0.725	0.735	.	4.620	3.530	1.438	1.305	0.751	1.000	0.999	0.997	433	p53,_DNA-binding_domain	.	.	ID=COSV52670786;OCCURENCE=1(breast),1(oesophagus),2(large_intestine),1(central_nervous_system),3(haematopoietic_and_lymphoid_tissue),1(urinary_tract),1(pancreas),1(skin),2(prostate),1(endometrium)	TP53	452	1	728	130	0.151515151515152	TRUE	TRUE
ENSG00000136492.9	.	BCM	GRCh38.p13	chr17	61799107	61799107	+	G	G	A	Missense_Mutation	SNP	ENST00000259008.7	exon9	c.C1333T	p.L445F	exonic	ENSG00000136492.9	.	nonsynonymous SNV	ENSG00000136492.9:ENST00000259008.7:exon9:c.C1333T:p.L445F	17q23.2	C3L-01051	.	.	.	.	.	.	.	.	.	15.20	D	T	D	D	D	D	M	T	D	0.527	D	D	D	0.540	0.423	0.980	0.461	T	T	D	D	D	D	3.502	24.700	0.999	D	N	0.643	6.389	0.631	6.635	0.205	0.615	0.654	0.659	0.655	.	5.610	5.610	3.555	1.176	0.618	1.000	1.000	0.996	47	.	.	.	.	BRIP1	464	2	410	69	0.144050104384134	TRUE	TRUE
ENSG00000182938.7	.	BCM	GRCh38.p13	chr17	74941593	74941593	+	G	G	A	Missense_Mutation	SNP	ENST00000328801.6	exon2	c.G220A	p.G74R	exonic	ENSG00000182938.7	.	nonsynonymous SNV	ENSG00000182938.7:ENST00000328801.6:exon2:c.G220A:p.G74R	17q25.1	C3L-01051	.	.	.	.	.	.	.	.	.	13.16	.	.	D	D	D	D	M	.	.	.	T	T	D	0.358	0.665	0.432	0.221	D	T	D	D	D	D	3.888	26.300	0.999	D	D	0.627	6.210	0.565	5.816	0.873	0.497	0.590	0.578	0.542	.	4.860	4.860	6.145	1.176	0.676	1.000	0.800	0.906	923	.	.	.	.	OTOP3	96	0	237	16	0.0632411067193676	TRUE	NA
ENSG00000105732.13	.	BCM	GRCh38.p13	chr19	42080648	42080648	+	G	G	T	Missense_Mutation	SNP	ENST00000359044.5	exon2	c.G2042T	p.R681L	exonic	ENSG00000105732.13	.	nonsynonymous SNV	ENSG00000105732.13:ENST00000359044.5:exon2:c.G2042T:p.R681L	19q13.2	C3L-01051	.	.	.	.	.	.	.	.	.	4.19	D	T	P	B	D	N	L	T	N	0.682	T	T	T	0.213	0.417	0.129	1.131	D	T	T	T	T	T	2.565	22.600	0.994	D	.	-0.418	1.344	-0.365	1.436	0.999	0.672	0.698	0.702	0.636	.	5.500	4.460	1.388	1.176	0.676	0.009	0.993	0.942	846	Zinc_finger_C2H2-type	.	.	.	ZNF574	253	0	585	51	0.080188679245283	TRUE	TRUE
ENSG00000186806.5	.	BCM	GRCh38.p13	chr19	51334281	51334281	+	T	T	A	Missense_Mutation	SNP	ENST00000335624.4	exon8	c.A2329T	p.I777F	exonic	ENSG00000186806.5	.	nonsynonymous SNV	ENSG00000186806.5:ENST00000335624.4:exon8:c.A2329T:p.I777F	19q13.41	C3L-01051	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	M	T	N	0.496	T	T	D	0.272	0.406	0.312	.	T	T	T	T	D	T	3.128	23.700	0.989	D	N	0.634	6.283	0.539	5.533	0.959	0.696	0.627	0.723	0.568	.	5.360	5.360	1.647	1.135	0.609	1.000	0.953	0.326	970	.	.	.	.	VSIG10L	246	0	458	96	0.173285198555957	TRUE	TRUE
ENSG00000087460.25	.	BCM	GRCh38.p13	chr20	58909365	58909365	+	C	C	T	Missense_Mutation	SNP	ENST00000371100.8	exon8	c.C2530T	p.R844C	exonic	ENSG00000087460.25	.	nonsynonymous SNV	ENSG00000087460.25:ENST00000371100.8:exon8:c.C2530T:p.R844C	20q13.32	C3L-01051	8.238e-06	0	8.64e-05	0	0	0	0	0	rs11554273	20.20	D	D	D	D	D	D	H	D	D	0.887	D	D	D	0.943	0.913	0.997	3.743	D	D	D	D	D	D	4.600	32	0.999	D	D	0.934	11.959	0.815	10.570	1.000	0.722	0.699	0.702	0.735	.	5.530	4.530	4.121	1.026	0.599	1.000	0.910	0.934	987	.	.	.	ID=COSV55670339;OCCURENCE=8(breast),5(parathyroid),12(liver),18(peritoneum),2(oesophagus),20(adrenal_gland),9(cervix),84(large_intestine),9(biliary_tract),17(ovary),83(bone),3(NS),3(haematopoietic_and_lymphoid_tissue),32(stomach),3(kidney),26(soft_tissue),265(pancreas),1(autonomic_ganglia),167(pituitary),2(skin),1(prostate),4(lung),8(thyroid),1(upper_aerodigestive_tract),2(testis),34(small_intestine)	GNAS	759	0	1469	20	0.0134318334452653	TRUE	NA
ENSG00000130939.20	.	BCM	GRCh38.p13	chr1	10178778	10178778	+	C	C	T	Silent	SNP	ENST00000343090.11	exon26	c.C3660T	p.R1220R	exonic	ENSG00000130939.20	.	synonymous SNV	ENSG00000130939.20:ENST00000343090.11:exon26:c.C3660T:p.R1220R	1p36.22	C3L-01051	0.0001	0.0014	0	0	0	1.503e-05	0	6.083e-05	rs146434563	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53538688;OCCURENCE=1(soft_tissue)	UBE4B	200	0	268	15	0.0530035335689046	TRUE	TRUE
ENSG00000171055.15	.	BCM	GRCh38.p13	chr2	36578600	36578600	+	G	G	A	Silent	SNP	ENST00000405912.8	exon5	c.C900T	p.G300G	exonic	ENSG00000171055.15	.	synonymous SNV	ENSG00000171055.15:ENST00000405912.8:exon5:c.C900T:p.G300G	2p22.2	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FEZ2	113	1	117	14	0.106870229007634	TRUE	TRUE
ENSG00000135636.14	.	BCM	GRCh38.p13	chr2	71513858	71513858	+	C	C	T	Silent	SNP	ENST00000258104.7	exon6	c.C600T	p.I200I	exonic	ENSG00000135636.14	.	synonymous SNV	ENSG00000135636.14:ENST00000258104.7:exon6:c.C600T:p.I200I	2p13.2	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DYSF	724	0	1245	216	0.147843942505133	TRUE	TRUE
ENSG00000144460.12	.	BCM	GRCh38.p13	chr2	225582635	225582635	+	C	C	T	Silent	SNP	ENST00000636099.1	exon5	c.C1218T	p.A406A	exonic	ENSG00000144460.12	.	synonymous SNV	ENSG00000144460.12:ENST00000636099.1:exon5:c.C1218T:p.A406A	2q36.3	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NYAP2	85	0	221	16	0.0675105485232067	TRUE	TRUE
ENSG00000104447.12	.	BCM	GRCh38.p13	chr8	115604886	115604886	+	G	G	A	Silent	SNP	ENST00000640765.1	exon3	c.C1044T	p.T348T	exonic	ENSG00000104447.12	.	synonymous SNV	ENSG00000104447.12:ENST00000640765.1:exon3:c.C1044T:p.T348T	8q23.3	C3L-01051	0.0005	0	0	0	0	0.0007	0.0011	0.0007	rs143724802	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRPS1	348	0	404	36	0.0818181818181818	TRUE	NA
ENSG00000214929.4	.	BCM	GRCh38.p13	chr9	81993554	81993554	+	T	T	C	Silent	SNP	ENST00000344803.3	exon4	c.T3084C	p.G1028G	exonic	ENSG00000214929.4	.	synonymous SNV	ENSG00000214929.4:ENST00000344803.3:exon4:c.T3084C:p.G1028G	9q21.32	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100782742;OCCURENCE=1(large_intestine)	SPATA31D1	232	0	210	37	0.149797570850202	TRUE	TRUE
ENSG00000165238.16	.	BCM	GRCh38.p13	chr9	93289353	93289353	+	G	G	A	Silent	SNP	ENST00000297954.8	exon20	c.G4710A	p.S1570S	exonic	ENSG00000165238.16	.	synonymous SNV	ENSG00000165238.16:ENST00000297954.8:exon20:c.G4710A:p.S1570S	9q22.31	C3L-01051	2.212e-05	0	0.0001	0	0	1.998e-05	0	0	rs750204095	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52950151;OCCURENCE=1(breast),1(stomach),1(skin)	WNK2	107	0	233	42	0.152727272727273	TRUE	TRUE
ENSG00000059915.17	.	BCM	GRCh38.p13	chr10	102413963	102413963	+	G	G	A	Silent	SNP	ENST00000020673.6	exon5	c.C1359T	p.P453P	exonic	ENSG00000059915.17	.	synonymous SNV	ENSG00000059915.17:ENST00000020673.6:exon5:c.C1359T:p.P453P	10q24.32	C3L-01051	4.156e-05	0	0	0	0	0	0	0.0003	rs745853601	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PSD	251	0	393	70	0.151187904967603	TRUE	NA
ENSG00000139549.4	.	BCM	GRCh38.p13	chr12	49090297	49090297	+	A	A	G	Silent	SNP	ENST00000649637.2	exon3	c.T753C	p.A251A	exonic	ENSG00000139549.4	.	synonymous SNV	ENSG00000139549.4:ENST00000649637.2:exon3:c.T753C:p.A251A	12q13.12	C3L-01051	3.228e-05	0.0003	0	0	0	0	0	0	rs146122556	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DHH	256	2	612	97	0.136812411847673	TRUE	NA
ENSG00000184445.12	.	BCM	GRCh38.p13	chr12	122610879	122610879	+	A	A	T	Silent	SNP	ENST00000333479.12	exon53	c.A5601T	p.V1867V	exonic	ENSG00000184445.12	.	synonymous SNV	ENSG00000184445.12:ENST00000333479.12:exon53:c.A5601T:p.V1867V	12q24.31	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KNTC1	297	0	206	39	0.159183673469388	TRUE	TRUE
ENSG00000152520.14	.	BCM	GRCh38.p13	chr13	28138915	28138915	+	C	C	A	Silent	SNP	ENST00000380958.8	exon1	c.C258A	p.V86V	exonic	ENSG00000152520.14	.	synonymous SNV	ENSG00000152520.14:ENST00000380958.8:exon1:c.C258A:p.V86V	13q12.2	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PAN3	25	0	61	24	0.282352941176471	TRUE	NA
ENSG00000125255.7	.	BCM	GRCh38.p13	chr13	103046190	103046190	+	C	C	T	Silent	SNP	ENST00000245312.5	exon6	c.G990A	p.T330T	exonic	ENSG00000125255.7	.	synonymous SNV	ENSG00000125255.7:ENST00000245312.5:exon6:c.G990A:p.T330T	13q33.1	C3L-01051	7.432e-05	0	0	0.0008	0	1.502e-05	0	6.064e-05	rs148791669	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55361238;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(skin)	SLC10A2	394	0	371	54	0.127058823529412	TRUE	TRUE
ENSG00000140598.15	.	BCM	GRCh38.p13	chr15	82151946	82151946	+	T	T	A	Silent	SNP	ENST00000268206.12	exon18	c.A2508T	p.L836L	exonic	ENSG00000140598.15	.	synonymous SNV	ENSG00000140598.15:ENST00000268206.12:exon18:c.A2508T:p.L836L	15q25.2	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EFL1	260	0	252	64	0.20253164556962	TRUE	TRUE
ENSG00000141052.17	.	BCM	GRCh38.p13	chr17	12753289	12753289	+	C	C	T	Silent	SNP	ENST00000343344.8	exon10	c.C2001T	p.A667A	exonic	ENSG00000141052.17	.	synonymous SNV	ENSG00000141052.17:ENST00000343344.8:exon10:c.C2001T:p.A667A	17p12	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYOCD	141	0	142	24	0.144578313253012	TRUE	TRUE
ENSG00000171446.7	.	BCM	GRCh38.p13	chr17	40779514	40779514	+	G	G	A	Silent	SNP	ENST00000301656.4	exon5	c.C960T	p.S320S	exonic	ENSG00000171446.7	.	synonymous SNV	ENSG00000171446.7:ENST00000301656.4:exon5:c.C960T:p.S320S	17q21.2	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KRT27	146	0	329	39	0.105978260869565	TRUE	TRUE
ENSG00000171446.7	.	BCM	GRCh38.p13	chr17	40779586	40779586	+	G	G	A	Silent	SNP	ENST00000301656.4	exon5	c.C888T	p.A296A	exonic	ENSG00000171446.7	.	synonymous SNV	ENSG00000171446.7:ENST00000301656.4:exon5:c.C888T:p.A296A	17q21.2	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KRT27	212	0	474	63	0.11731843575419	TRUE	TRUE
ENSG00000105246.6	.	BCM	GRCh38.p13	chr19	4233177	4233177	+	G	G	C	Silent	SNP	ENST00000221847.6	exon3	c.G249C	p.T83T	exonic	ENSG00000105246.6	.	synonymous SNV	ENSG00000105246.6:ENST00000221847.6:exon3:c.G249C:p.T83T	19p13.3	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EBI3	163	0	283	67	0.191428571428571	TRUE	TRUE
ENSG00000149639.15	.	BCM	GRCh38.p13	chr20	36817446	36817446	+	G	G	A	Silent	SNP	ENST00000237536.9	exon4	c.C1095T	p.T365T	exonic	ENSG00000149639.15	.	synonymous SNV	ENSG00000149639.15:ENST00000237536.9:exon4:c.C1095T:p.T365T	20q11.23	C3L-01051	.	.	.	.	.	.	.	.	rs371451776	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SOGA1	372	0	527	66	0.111298482293423	TRUE	NA
ENSG00000142192.21	.	BCM	GRCh38.p13	chr21	26053290	26053290	+	C	C	T	Silent	SNP	ENST00000346798.8	exon4	c.G414A	p.Q138Q	exonic	ENSG00000142192.21	.	synonymous SNV	ENSG00000142192.21:ENST00000346798.8:exon4:c.G414A:p.Q138Q	21q21.3	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100696279;OCCURENCE=1(central_nervous_system)	APP	476	0	531	50	0.0860585197934595	TRUE	TRUE
ENSG00000273361.1	.	BCM	GRCh38.p13	chr2	218398478	218398478	+	G	G	A	3'Flank	SNP	NA	NA	NA	NA	downstream	ENSG00000273361.1	dist=265	.	.	2q35	C3L-01051	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC021016.2	112	0	280	21	0.0697674418604651	TRUE	NA
ENSG00000120952.4	.	BCM	GRCh38.p13	chr1	12859974	12859974	+	C	C	T	Missense_Mutation	SNP	ENST00000240189.2	exon3	c.C569T	p.T190M	exonic	ENSG00000120952.4	.	nonsynonymous SNV	ENSG00000120952.4:ENST00000240189.2:exon3:c.C569T:p.T190M	1p36.21	C3N-01716	0.0006	0	0.0003	0	0	3.007e-05	0	0.0044	rs374389020	0.19	T	T	P	B	N	N	N	T	N	0.055	T	T	T	0.109	.	0.014	0.050	T	T	T	T	T	.	-0.707	0.042	0.047	N	N	-1.494	0.083	-1.546	0.092	0.000	0.487	0.547	0.547	0.564	.	0.842	-0.902	-0.645	-1.179	-0.390	0.000	0.000	0.001	940	.	.	.	ID=COSV53575185;OCCURENCE=1(central_nervous_system),1(haematopoietic_and_lymphoid_tissue),1(kidney)	PRAMEF2	315	0	405	74	0.154488517745303	NA	TRUE
ENSG00000180708.5	.	BCM	GRCh38.p13	chr1	158420502	158420502	+	C	C	T	Missense_Mutation	SNP	ENST00000641042.1	exon2	c.G365A	p.R122H	exonic	ENSG00000180708.5	.	nonsynonymous SNV	ENSG00000180708.5:ENST00000641042.1:exon2:c.G365A:p.R122H	1q23.1	C3N-01716	0.0002	0	0.0003	0.0019	0	0	0	0	rs762306649	12.20	D	D	P	B	D	D	M	T	D	0.436	D	T	D	0.554	0.473	0.845	0.015	T	T	T	T	D	D	2.468	22.300	0.998	D	D	0.441	4.609	0.362	4.102	1.000	0.487	0.574	0.658	0.564	.	4.100	4.100	5.780	0.877	0.547	1.000	0.059	0.195	738	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV59220549;OCCURENCE=1(large_intestine),1(central_nervous_system),1(stomach)	OR10K2	597	0	671	149	0.181707317073171	TRUE	TRUE
ENSG00000116147.17	.	BCM	GRCh38.p13	chr1	175337560	175337560	+	A	A	C	Missense_Mutation	SNP	ENST00000367674.7	exon19	c.T3502G	p.C1168G	exonic	ENSG00000116147.17	.	nonsynonymous SNV	ENSG00000116147.17:ENST00000367674.7:exon19:c.T3502G:p.C1168G	1q25.1	C3N-01716	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.967	D	D	D	0.925	0.833	0.983	2.041	T	D	D	D	D	D	4.165	28.300	0.987	D	D	0.990	13.598	0.887	13.192	0.997	0.516	0.563	0.547	0.586	.	5.230	5.230	8.818	1.312	0.756	1.000	0.954	0.863	647	Fibrinogen,_alpha/beta/gamma_chain,_C-terminal_globular_domain	.	.	.	TNR	274	0	416	80	0.161290322580645	TRUE	TRUE
ENSG00000163328.13	.	BCM	GRCh38.p13	chr2	174481667	174481667	+	T	T	C	Missense_Mutation	SNP	ENST00000392552.6	exon2	c.A290G	p.N97S	exonic	ENSG00000163328.13	.	nonsynonymous SNV	ENSG00000163328.13:ENST00000392552.6:exon2:c.A290G:p.N97S	2q31.1	C3N-01716	1.649e-05	0	0	0	0	1.499e-05	0.0011	0	rs376481034	5.20	T	T	B	B	D	D	L	T	N	0.479	T	T	T	0.071	.	0.321	0.199	T	T	T	T	T	D	2.242	21.200	0.342	D	D	-0.279	1.665	0.002	2.365	1.000	0.638	0.670	0.574	0.621	.	5.790	5.790	4.959	1.138	0.665	1.000	0.999	0.998	934	.	.	.	.	GPR155	389	0	413	74	0.151950718685832	TRUE	NA
ENSG00000078295.17	.	BCM	GRCh38.p13	chr5	7414671	7414671	+	G	G	-	Frame_Shift_Del	NA	ENST00000338316.9	exon2	c.309delG	p.K104Sfs*9	exonic	ENSG00000078295.17	.	frameshift deletion	ENSG00000078295.17:ENST00000338316.9:exon2:c.309delG:p.K104Sfs*9	5p15.31	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADCY2	296	0	354	48	0.119402985074627	TRUE	TRUE
ENSG00000204963.6	.	BCM	GRCh38.p13	chr5	140836227	140836227	+	C	C	T	Missense_Mutation	SNP	ENST00000525929.2	exon1	c.C1844T	p.A615V	exonic	ENSG00000204963.6	.	nonsynonymous SNV	ENSG00000204963.6:ENST00000525929.2:exon1:c.C1844T:p.A615V	5q31.3	C3N-01716	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	.	N	N	T	N	0.073	T	T	T	0.011	0.274	0.479	.	.	T	T	T	T	T	0.164	2.726	0.938	N	N	-1.046	0.357	-1.064	0.414	0.000	0.554	0.588	0.602	0.613	.	3.670	1.820	-1.150	-0.334	0.500	0.000	0.000	0.002	31	Cadherin-like	.	.	ID=COSV65346513;OCCURENCE=1(large_intestine)	PCDHA7	502	1	760	163	0.176598049837486	TRUE	TRUE
ENSG00000082556.13	.	BCM	GRCh38.p13	chr8	53229359	53229359	+	G	G	A	Nonsense_Mutation	SNP	ENST00000265572.8	exon4	c.C1081T	p.R361X	exonic	ENSG00000082556.13	.	stopgain	ENSG00000082556.13:ENST00000265572.8:exon4:c.C1081T:p.R361X	8q11.23	C3N-01716	8.241e-06	0	0	0.0001	0	0	0	0	rs745533525	4.6	.	.	.	.	D	D	.	.	.	0.877	.	.	.	.	.	.	.	.	.	D	D	.	.	7.193	37	0.986	N	N	-0.097	2.184	-0.379	1.410	0.000	0.554	0.574	0.602	0.564	.	5.800	-1.160	-0.023	0.154	-0.270	0.006	0.549	0.966	896	.	.	.	ID=COSV55569565;OCCURENCE=2(large_intestine),1(central_nervous_system),2(stomach)	OPRK1	211	0	327	69	0.174242424242424	TRUE	TRUE
ENSG00000154493.19	.	BCM	GRCh38.p13	chr10	126504763	126504763	+	C	C	T	Missense_Mutation	SNP	ENST00000284694.11	exon3	c.G437A	p.R146H	exonic	ENSG00000154493.19	.	nonsynonymous SNV	ENSG00000154493.19:ENST00000284694.11:exon3:c.G437A:p.R146H	10q26.2	C3N-01716	.	.	.	.	.	.	.	.	rs372468399	13.19	D	D	D	D	D	D	M	T	D	0.672	T	T	T	0.192	.	0.406	0.474	.	T	D	D	D	D	3.546	24.900	1.000	D	N	0.596	5.880	0.541	5.557	0.997	0.487	0.574	0.578	0.564	.	5.100	5.100	2.401	1.026	0.599	0.971	0.232	0.516	609	.	.	.	ID=COSV52948763;OCCURENCE=1(oesophagus),1(stomach),1(haematopoietic_and_lymphoid_tissue),1(kidney),1(pancreas)	C10orf90	86	0	105	35	0.25	TRUE	TRUE
ENSG00000149328.15	.	BCM	GRCh38.p13	chr11	134371830	134371830	+	G	G	A	Missense_Mutation	SNP	ENST00000535456.7	exon15	c.G1507A	p.G503S	exonic	ENSG00000149328.15	.	nonsynonymous SNV	ENSG00000149328.15:ENST00000535456.7:exon15:c.G1507A:p.G503S	11q25	C3N-01716	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.948	D	D	D	0.964	0.823	0.613	0.668	T	D	D	D	D	D	7.141	37	0.999	D	D	1.069	16.248	0.988	18.129	1.000	0.660	0.588	0.696	0.568	.	5.600	5.600	8.403	1.166	0.665	1.000	1.000	0.976	975	.	.	.	.	GLB1L2	250	0	300	68	0.184782608695652	TRUE	TRUE
ENSG00000111247.14	.	BCM	GRCh38.p13	chr12	4543797	4543797	+	G	G	T	Missense_Mutation	SNP	ENST00000228843.13	exon3	c.G102T	p.K34N	exonic	ENSG00000111247.14	.	nonsynonymous SNV	ENSG00000111247.14:ENST00000228843.13:exon3:c.G102T:p.K34N	12p13.32	C3N-01716	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	D	0.735	T	T	T	0.113	0.330	0.330	0.550	T	T	T	T	D	D	3.758	25.600	0.998	D	N	0.291	3.733	0.239	3.378	0.950	0.706	0.710	0.725	0.613	.	5.060	2.950	1.431	1.155	0.618	1.000	0.990	0.992	860	.	.	.	.	RAD51AP1	217	0	201	52	0.205533596837945	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-01716	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	397	0	468	96	0.170212765957447	TRUE	TRUE
ENSG00000079337.16	.	BCM	GRCh38.p13	chr12	47749470	47749470	+	G	G	A	Missense_Mutation	SNP	ENST00000449771.7	exon10	c.C961T	p.R321W	exonic	ENSG00000079337.16	.	nonsynonymous SNV	ENSG00000079337.16:ENST00000449771.7:exon10:c.C961T:p.R321W	12q13.11	C3N-01716	8.263e-06	9.645e-05	0	0	0	0	0	0	rs761190001	20.20	D	D	D	D	D	D	H	D	D	0.995	D	D	D	0.865	0.631	0.986	0.787	D	D	D	D	D	D	4.225	28.900	0.999	D	D	0.946	12.291	0.807	10.344	1.000	0.706	0.634	0.710	0.714	.	4.280	4.280	2.639	1.176	0.676	0.998	0.998	0.996	894	Cyclic_nucleotide-binding_domain	.	.	.	RAPGEF3	277	0	533	130	0.196078431372549	TRUE	NA
ENSG00000139797.8	.	BCM	GRCh38.p13	chr13	98176495	98176495	+	C	C	T	Missense_Mutation	SNP	ENST00000267291.7	exon1	c.G742A	p.E248K	exonic	ENSG00000139797.8	.	nonsynonymous SNV	ENSG00000139797.8:ENST00000267291.7:exon1:c.G742A:p.E248K	13q32.2	C3N-01716	1.647e-05	9.61e-05	0	0	0	1.498e-05	0	0	rs376379120	4.20	T	D	B	B	U	D	L	T	N	0.219	T	T	T	0.119	.	0.468	0.549	T	T	T	T	T	D	1.666	16.800	0.992	D	N	-0.645	0.907	-0.683	0.925	1.000	0.554	0.588	0.604	0.728	.	1.570	0.678	3.758	-0.201	0.549	1.000	0.003	0.009	691	.	.	.	.	RNF113B	502	0	640	152	0.191919191919192	TRUE	NA
ENSG00000185518.11	.	BCM	GRCh38.p13	chr15	91251950	91251950	+	G	G	A	Missense_Mutation	SNP	ENST00000394232.5	exon3	c.G583A	p.V195M	exonic	ENSG00000185518.11	.	nonsynonymous SNV	ENSG00000185518.11:ENST00000394232.5:exon3:c.G583A:p.V195M	15q26.1	C3N-01716	3.295e-05	0	8.642e-05	0	0	2.998e-05	0	6.058e-05	rs776050433	12.20	T	D	D	D	D	D	L	T	N	0.694	D	D	T	0.487	0.673	0.731	0.962	T	T	T	D	D	D	3.128	23.700	0.999	D	D	0.756	7.989	0.735	8.463	1.000	0.549	0.627	0.618	0.564	.	5.380	5.380	7.767	1.176	0.676	1.000	0.998	0.793	809	Major_facilitator_superfamily_domain	.	.	ID=COSV100370469;OCCURENCE=1(large_intestine)	SV2B	216	0	339	84	0.198581560283688	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674945	7674945	+	G	G	A	Nonsense_Mutation	SNP	ENST00000269305.8	exon6	c.C586T	p.R196X	exonic	ENSG00000141510.17	.	stopgain	ENSG00000141510.17:ENST00000269305.8:exon6:c.C586T:p.R196X	17p13.1	C3N-01716	8.24e-06	0	0	0	0	1.499e-05	0	0	rs397516435	5.6	.	.	.	.	D	A	.	.	.	0.973	.	.	.	.	.	.	.	.	.	D	D	.	.	7.664	39	0.995	D	N	0.403	4.363	0.225	3.306	0.406	0.722	0.698	0.702	0.735	.	5.410	4.440	2.230	1.176	0.676	1.000	1.000	0.996	433	p53,_DNA-binding_domain	.	.	ID=COSV52663748;OCCURENCE=2(salivary_gland),52(breast),3(penis),1(liver),32(oesophagus),1(cervix),115(large_intestine),24(central_nervous_system),10(biliary_tract),17(ovary),9(NS),27(haematopoietic_and_lymphoid_tissue),35(stomach),1(soft_tissue),5(kidney),7(urinary_tract),21(pancreas),29(skin),6(prostate),19(lung),3(thyroid),24(upper_aerodigestive_tract),1(small_intestine),4(endometrium)	TP53	574	0	700	195	0.217877094972067	TRUE	TRUE
ENSG00000101574.15	.	BCM	GRCh38.p13	chr18	2566868	2566868	+	G	G	T	Missense_Mutation	SNP	ENST00000574538.2	exon2	c.C349A	p.L117M	exonic	ENSG00000101574.15	.	nonsynonymous SNV	ENSG00000101574.15:ENST00000574538.2:exon2:c.C349A:p.L117M	18p11.32	C3N-01716	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.132	T	T	T	0.097	0.242	0.181	0.111	T	T	T	T	T	T	0.585	7.362	0.928	N	N	-0.704	0.806	-0.735	0.850	0.999	0.651	0.654	0.651	0.636	.	4.900	0.987	-0.340	0.141	0.596	0.000	0.056	0.951	748	.	.	.	.	METTL4	131	1	161	22	0.120218579234973	TRUE	TRUE
ENSG00000101574.15	.	BCM	GRCh38.p13	chr18	2566904	2566904	+	G	G	C	Missense_Mutation	SNP	ENST00000574538.2	exon2	c.C313G	p.H105D	exonic	ENSG00000101574.15	.	nonsynonymous SNV	ENSG00000101574.15:ENST00000574538.2:exon2:c.C313G:p.H105D	18p11.32	C3N-01716	.	.	.	.	.	.	.	.	rs993396428	1.20	T	T	B	B	N	N	M	T	N	0.267	T	T	T	0.048	0.275	0.203	0.134	T	T	T	T	T	T	0.502	6.530	0.722	N	N	-0.992	0.413	-1.014	0.471	0.999	0.651	0.654	0.651	0.636	.	5.420	0.051	1.236	0.179	-0.202	0.002	0.923	0.694	748	.	.	.	.	METTL4	206	0	271	41	0.131410256410256	TRUE	TRUE
ENSG00000101574.15	.	BCM	GRCh38.p13	chr18	2567050	2567050	+	G	G	C	Missense_Mutation	SNP	ENST00000574538.2	exon2	c.C167G	p.S56C	exonic	ENSG00000101574.15	.	nonsynonymous SNV	ENSG00000101574.15:ENST00000574538.2:exon2:c.C167G:p.S56C	18p11.32	C3N-01716	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.155	T	T	T	0.038	0.302	0.187	0.094	T	T	T	T	T	T	0.854	9.939	0.887	N	N	-1.194	0.231	-1.187	0.294	1.000	0.707	0.654	0.725	0.636	.	5.340	-2.810	0.172	0.232	-0.273	0.003	0.070	0.019	748	.	.	.	ID=COSV55249767;OCCURENCE=1(urinary_tract)	METTL4	252	0	360	58	0.138755980861244	TRUE	TRUE
ENSG00000101574.15	.	BCM	GRCh38.p13	chr18	2567160	2567160	+	G	G	C	Missense_Mutation	SNP	ENST00000574538.2	exon2	c.C57G	p.I19M	exonic	ENSG00000101574.15	.	nonsynonymous SNV	ENSG00000101574.15:ENST00000574538.2:exon2:c.C57G:p.I19M	18p11.32	C3N-01716	.	.	.	.	.	.	.	.	.	7.19	D	D	P	P	D	N	M	T	N	0.536	T	T	T	0.131	0.479	0.340	0.396	T	T	T	T	D	D	2.770	23.000	0.994	D	.	0.078	2.798	0.074	2.632	1.000	0.707	0.654	0.609	0.714	.	5.860	2.290	1.060	0.232	-0.273	1.000	0.997	0.971	748	.	.	.	.	METTL4	147	0	204	29	0.124463519313305	TRUE	TRUE
ENSG00000101680.15	.	BCM	GRCh38.p13	chr18	7011322	7011322	+	G	G	A	Missense_Mutation	SNP	ENST00000389658.4	exon25	c.C3665T	p.P1222L	exonic	ENSG00000101680.15	.	nonsynonymous SNV	ENSG00000101680.15:ENST00000389658.4:exon25:c.C3665T:p.P1222L	18p11.31	C3N-01716	2.298e-05	0.0002	0	0	0	2.089e-05	0	0	rs762725918	17.20	D	D	D	D	D	D	H	T	D	0.738	D	D	D	0.600	0.838	0.943	0.533	T	T	D	D	D	D	4.107	27.800	0.999	D	D	0.839	9.602	0.752	8.857	1.000	0.732	0.574	0.744	0.564	.	5.870	5.870	9.120	1.172	0.660	1.000	0.781	0.371	839	Laminin_IV	.	.	.	LAMA1	356	0	624	342	0.354037267080745	TRUE	NA
ENSG00000125755.19	.	BCM	GRCh38.p13	chr19	45847929	45847929	+	C	C	T	Missense_Mutation	SNP	ENST00000245934.12	exon7	c.G499A	p.D167N	exonic	ENSG00000125755.19	.	nonsynonymous SNV	ENSG00000125755.19:ENST00000245934.12:exon7:c.G499A:p.D167N	19q13.32	C3N-01716	.	.	.	.	.	.	.	.	.	6.19	T	T	B	B	D	D	L	.	N	0.582	T	T	T	0.147	0.266	0.129	0.636	T	T	T	T	D	D	2.642	22.700	0.999	D	D	0.304	3.801	0.449	4.724	1.000	0.707	0.702	0.725	0.714	.	5.500	5.500	7.241	1.012	0.583	1.000	0.999	0.988	779	Symplekin/Pta1,_N-terminal	.	.	.	SYMPK	142	0	173	55	0.241228070175439	TRUE	TRUE
ENSG00000170471.15	.	BCM	GRCh38.p13	chr20	38574248	38574248	+	A	A	C	Missense_Mutation	SNP	ENST00000262879.11	exon29	c.A4241C	p.N1414T	exonic	ENSG00000170471.15	.	nonsynonymous SNV	ENSG00000170471.15:ENST00000262879.11:exon29:c.A4241C:p.N1414T	20q11.23	C3N-01716	.	.	.	.	.	.	.	.	.	10.20	D	T	B	B	D	D	L	D	N	0.374	D	D	D	0.344	0.550	0.220	0.446	T	T	T	T	D	D	2.320	21.700	0.988	D	N	0.002	2.517	0.213	3.245	0.541	0.732	0.744	0.744	0.728	.	6.020	6.020	4.400	1.312	0.756	1.000	0.994	0.992	928	.	.	.	.	RALGAPB	171	1	235	38	0.139194139194139	TRUE	TRUE
ENSG00000101180.16	.	BCM	GRCh38.p13	chr20	62216338	62216338	+	G	G	A	Missense_Mutation	SNP	ENST00000340177.10	exon3	c.C1006T	p.R336C	exonic	ENSG00000101180.16	.	nonsynonymous SNV	ENSG00000101180.16:ENST00000340177.10:exon3:c.C1006T:p.R336C	20q13.33	C3N-01716	.	.	.	.	.	.	.	.	.	13.20	D	D	B	B	N	D	M	T	D	0.460	D	D	D	0.343	0.505	0.851	1.397	D	D	T	T	D	D	3.490	24.700	0.999	D	N	0.272	3.640	0.280	3.603	0.583	0.696	0.547	0.723	0.563	.	4.610	3.540	1.384	1.152	0.650	1.000	1.000	0.985	856	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV100420461;OCCURENCE=1(endometrium)	HRH3	116	0	199	33	0.142241379310345	TRUE	TRUE
ENSG00000099949.21	.	BCM	GRCh38.p13	chr22	20982516	20982516	+	G	G	A	Missense_Mutation	SNP	ENST00000646124.2	exon1	c.G145A	p.E49K	exonic	ENSG00000099949.21	.	nonsynonymous SNV	ENSG00000099949.21:ENST00000646124.2:exon1:c.G145A:p.E49K	22q11.21	C3N-01716	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	N	0.595	T	T	D	0.304	0.625	0.431	1.665	D	T	D	D	D	D	4.709	32	0.999	D	D	0.765	8.138	0.775	9.414	1.000	0.767	0.522	0.851	0.562	.	5.550	5.550	5.795	1.172	0.672	1.000	1.000	0.998	934	.	.	.	.	LZTR1	390	1	798	149	0.157338965153115	TRUE	NA
ENSG00000185448.10	.	BCM	GRCh38.p13	chrX	34131290	34131290	+	G	G	A	Missense_Mutation	SNP	ENST00000346193.4	exon1	c.C989T	p.P330L	exonic	ENSG00000185448.10	.	nonsynonymous SNV	ENSG00000185448.10:ENST00000346193.4:exon1:c.C989T:p.P330L	Xp21.1	C3N-01716	.	.	.	.	.	.	.	.	.	5.18	D	D	D	D	.	N	L	T	D	0.072	T	T	T	0.081	0.202	0.043	0.775	T	T	T	T	T	T	1.520	15.870	0.910	N	.	.	.	.	.	0.000	.	.	.	.	.	0.226	-0.452	-0.708	-2.491	-1.500	0.001	0.000	0.000	937	.	.	.	ID=COSV60500739;OCCURENCE=1(endometrium)	FAM47A	180	1	195	74	0.275092936802974	TRUE	TRUE
ENSG00000147050.15	.	BCM	GRCh38.p13	chrX	45082585	45082585	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000377967.8	exon21	c.3155dupA	p.R1054Kfs*5	exonic	ENSG00000147050.15	.	frameshift insertion	ENSG00000147050.15:ENST00000377967.8:exon21:c.3155dupA:p.R1054Kfs*5	Xp11.3	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KDM6A	NA	NA	NA	NA	NA	NA	NA
ENSG00000196208.14	.	BCM	GRCh38.p13	chr2	11640364	11640364	+	C	C	T	Silent	SNP	ENST00000381486.7	exon33	c.C5760T	p.D1920D	exonic	ENSG00000196208.14	.	synonymous SNV	ENSG00000196208.14:ENST00000381486.7:exon33:c.C5760T:p.D1920D	2p25.1	C3N-01716	8.29e-06	0	0	0.0001	0	0	0	0	rs780513457	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52191810;OCCURENCE=1(large_intestine),1(central_nervous_system)	GREB1	230	0	488	88	0.152777777777778	TRUE	TRUE
ENSG00000175497.17	.	BCM	GRCh38.p13	chr2	115499583	115499583	+	A	A	G	Silent	SNP	ENST00000410059.6	exon4	c.A345G	p.L115L	exonic	ENSG00000175497.17	.	synonymous SNV	ENSG00000175497.17:ENST00000410059.6:exon4:c.A345G:p.L115L	2q14.1	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DPP10	187	0	131	17	0.114864864864865	TRUE	NA
ENSG00000182568.17	.	BCM	GRCh38.p13	chr3	18420788	18420788	+	C	C	T	Silent	SNP	ENST00000338745.11	exon2	c.G180A	p.S60S	exonic	ENSG00000182568.17	.	synonymous SNV	ENSG00000182568.17:ENST00000338745.11:exon2:c.G180A:p.S60S	3p24.3	C3N-01716	2.471e-05	0.0002	0	0	0	0	0	6.056e-05	rs138373358	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SATB1	351	0	530	127	0.193302891933029	TRUE	NA
ENSG00000145642.12	.	BCM	GRCh38.p13	chr5	64695600	64695600	+	G	G	A	Silent	SNP	ENST00000389074.6	exon2	c.G285A	p.T95T	exonic	ENSG00000145642.12	.	synonymous SNV	ENSG00000145642.12:ENST00000389074.6:exon2:c.G285A:p.T95T	5q12.3	C3N-01716	.	.	.	.	.	.	.	.	rs563854983	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66619529;OCCURENCE=1(oesophagus),1(biliary_tract),1(skin)	SHISAL2B	197	1	184	40	0.178571428571429	TRUE	TRUE
ENSG00000178764.8	.	BCM	GRCh38.p13	chr8	122952671	122952671	+	C	C	T	Silent	SNP	ENST00000314393.6	exon3	c.C1161T	p.T387T	exonic	ENSG00000178764.8	.	synonymous SNV	ENSG00000178764.8:ENST00000314393.6:exon3:c.C1161T:p.T387T	8q24.13	C3N-01716	8.245e-06	0	0	0	0	1.5e-05	0	0	rs530836451	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZHX2	421	0	679	126	0.156521739130435	TRUE	NA
ENSG00000107282.8	.	BCM	GRCh38.p13	chr9	69517130	69517130	+	G	G	A	Silent	SNP	ENST00000265381.7	exon2	c.C81T	p.A27A	exonic	ENSG00000107282.8	.	synonymous SNV	ENSG00000107282.8:ENST00000265381.7:exon2:c.C81T:p.A27A	9q21.12	C3N-01716	.	.	.	.	.	.	.	.	rs902513997	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55237360;OCCURENCE=1(skin)	APBA1	70	0	193	110	0.363036303630363	TRUE	TRUE
ENSG00000148400.12	.	BCM	GRCh38.p13	chr9	136508900	136508900	+	G	G	A	Silent	SNP	ENST00000651671.1	exon19	c.C3141T	p.C1047C	exonic	ENSG00000148400.12	.	synonymous SNV	ENSG00000148400.12:ENST00000651671.1:exon19:c.C3141T:p.C1047C	9q34.3	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NOTCH1	146	0	222	127	0.363896848137536	TRUE	NA
ENSG00000188162.11	.	BCM	GRCh38.p13	chr11	17557247	17557247	+	A	A	G	Silent	SNP	ENST00000399391.7	exon7	c.A825G	p.P275P	exonic	ENSG00000188162.11	.	synonymous SNV	ENSG00000188162.11:ENST00000399391.7:exon7:c.A825G:p.P275P	11p15.1	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OTOG	363	0	624	154	0.197943444730077	TRUE	TRUE
ENSG00000101574.15	.	BCM	GRCh38.p13	chr18	2566839	2566839	+	G	G	T	Silent	SNP	ENST00000574538.2	exon2	c.C378A	p.S126S	exonic	ENSG00000101574.15	.	synonymous SNV	ENSG00000101574.15:ENST00000574538.2:exon2:c.C378A:p.S126S	18p11.32	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	METTL4	83	1	107	13	0.108333333333333	TRUE	TRUE
ENSG00000142279.13	.	BCM	GRCh38.p13	chr19	34482436	34482436	+	C	C	G	Silent	SNP	ENST00000590071.7	exon1	c.C462G	p.G154G	exonic	ENSG00000142279.13	.	synonymous SNV	ENSG00000142279.13:ENST00000590071.7:exon1:c.C462G:p.G154G	19q13.11	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WTIP	79	0	189	53	0.21900826446281	TRUE	TRUE
ENSG00000171587.15	.	BCM	GRCh38.p13	chr21	40124297	40124297	+	C	C	T	Silent	SNP	ENST00000400454.6	exon20	c.G3594A	p.A1198A	exonic	ENSG00000171587.15	.	synonymous SNV	ENSG00000171587.15:ENST00000400454.6:exon20:c.G3594A:p.A1198A	21q22.2	C3N-01716	0.0001	0	0	0.0015	0	0	0	6.056e-05	rs745904747	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV68027549;OCCURENCE=1(stomach)	DSCAM	225	0	344	66	0.160975609756098	TRUE	TRUE
ENSG00000160216.21	.	BCM	GRCh38.p13	chr21	43969165	43969165	+	C	C	T	Silent	SNP	ENST00000291572.13	exon5	c.C396T	p.I132I	exonic	ENSG00000160216.21	.	synonymous SNV	ENSG00000160216.21:ENST00000291572.13:exon5:c.C396T:p.I132I	21q22.3	C3N-01716	4.945e-05	0	0.0004	0	0	1.499e-05	0	0	rs777102711	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AGPAT3	230	0	409	90	0.180360721442886	TRUE	NA
ENSG00000112855.17	.	BCM	GRCh38.p13	chr5	140693570	140693570	+	T	T	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000112855.17	.	.	.	5q31.3	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HARS2	493	0	732	138	0.158620689655172	TRUE	NA
ENSG00000197343.11	.	BCM	GRCh38.p13	chr7	99563889	99563889	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000197343.11;ENSG00000272647.3	.	.	.	7q22.1	C3N-01716	1.659e-05	0	8.693e-05	0	0	0	0	6.067e-05	rs776026660	9.16	D	D	D	D	.	D	.	T	D	0.585	T	T	T	0.080	0.306	0.482	.	.	.	T	T	T	D	2.216	21.000	0.999	D	D	0.441	4.610	0.436	4.626	1.000	0.719	0.723	0.698	0.636	.	4.140	4.140	1.885	1.026	0.599	1.000	1.000	0.997	281	.	.	.	.	ZNF655	336	0	481	110	0.186125211505922	TRUE	NA
ENSG00000101158.15	.	BCM	GRCh38.p13	chr20	58989739	58989739	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000101158.15	.	.	.	20q13.32	C3N-01716	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NELFCD	203	0	288	54	0.157894736842105	TRUE	NA
ENSG00000169991.11	.	BCM	GRCh38.p13	chr1	18921098	18921098	+	C	C	T	Missense_Mutation	SNP	ENST00000455833.7	exon2	c.G689A	p.R230H	exonic	ENSG00000169991.11	.	nonsynonymous SNV	ENSG00000169991.11:ENST00000455833.7:exon2:c.G689A:p.R230H	1p36.13	C3N-03839	.	.	.	.	.	.	.	.	rs979878869	14.20	D	D	P	B	D	D	M	D	D	0.565	D	D	D	0.681	.	0.958	1.748	T	T	T	D	D	T	4.136	28.100	1.000	D	D	0.519	5.190	0.568	5.844	1.000	0.672	0.654	0.659	0.711	.	4.840	4.840	7.011	1.026	0.599	1.000	0.996	0.995	940	Intermediate_filament,_rod_domain	.	.	ID=COSV69085783;OCCURENCE=1(stomach)	IFFO2	376	1	539	96	0.151181102362205	TRUE	TRUE
ENSG00000133216.16	.	BCM	GRCh38.p13	chr1	22785052	22785052	+	G	G	A	Missense_Mutation	SNP	ENST00000400191.7	exon3	c.G787A	p.V263I	exonic	ENSG00000133216.16	.	nonsynonymous SNV	ENSG00000133216.16:ENST00000400191.7:exon3:c.G787A:p.V263I	1p36.12	C3N-03839	8.386e-05	0	0	0	0	7.676e-05	0	0.0003	rs150803261	5.20	T	T	P	B	D	D	M	T	N	0.332	T	T	D	0.139	.	0.686	0.475	T	T	T	T	T	T	2.063	19.740	0.983	D	N	-0.026	2.419	0.056	2.561	0.985	0.707	0.588	0.725	0.714	.	5.120	4.210	4.510	0.227	-0.161	1.000	0.997	0.953	473	Tyrosine-protein_kinase_ephrin_type_A/B_receptor-like	.	.	.	EPHB2	288	1	450	87	0.162011173184358	TRUE	NA
ENSG00000116525.14	.	BCM	GRCh38.p13	chr1	33147391	33147391	+	G	G	A	Missense_Mutation	SNP	ENST00000291416.10	exon5	c.C1214T	p.T405M	exonic	ENSG00000116525.14	.	nonsynonymous SNV	ENSG00000116525.14:ENST00000291416.10:exon5:c.C1214T:p.T405M	1p35.1	C3N-03839	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.683	D	D	D	0.608	0.531	0.900	1.790	T	T	T	T	D	D	4.076	27.600	0.999	D	D	0.780	8.404	0.721	8.167	1.000	0.615	0.577	0.659	0.636	.	5.680	4.760	8.138	1.157	0.595	1.000	0.994	0.988	470	0.000	.	.	ID=COSV52221226;OCCURENCE=1(stomach)	TRIM62	464	0	662	126	0.15989847715736	TRUE	TRUE
ENSG00000163867.17	.	BCM	GRCh38.p13	chr1	35010518	35010518	+	T	T	C	Missense_Mutation	SNP	ENST00000357182.9	exon10	c.A1421G	p.Y474C	exonic	ENSG00000163867.17;ENSG00000271741.1	.	nonsynonymous SNV	ENSG00000163867.17:ENST00000357182.9:exon10:c.A1421G:p.Y474C,ENSG00000271741.1:ENST00000487874.1:exon10:c.A1421G:p.Y474C	1p34.3	C3N-03839	.	.	.	.	.	.	.	.	.	10.20	D	T	D	D	N	D	M	T	D	0.802	T	T	T	0.293	0.660	0.153	0.896	T	T	T	T	D	D	4.183	28.500	0.998	D	D	0.703	7.165	0.669	7.216	1.000	0.707	0.725	0.609	0.636	.	5.030	5.030	5.466	1.124	0.665	1.000	1.000	0.999	907	Zinc_finger,_MYM-type;TRASH_domain	.	.	.	ZMYM6	236	0	361	49	0.119512195121951	TRUE	TRUE
ENSG00000157131.11	.	BCM	GRCh38.p13	chr1	56917712	56917712	+	G	G	T	Missense_Mutation	SNP	ENST00000361249.4	exon11	c.G1751T	p.C584F	exonic	ENSG00000157131.11	.	nonsynonymous SNV	ENSG00000157131.11:ENST00000361249.4:exon11:c.G1751T:p.C584F	1p32.2	C3N-03839	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	D	D	0.892	D	D	D	0.819	0.727	0.901	0.287	T	T	D	D	D	T	3.599	25.000	0.992	D	D	0.860	10.058	0.678	7.364	0.999	0.487	0.574	0.547	0.564	.	4.820	4.820	6.364	1.176	0.676	1.000	0.249	0.126	871	.	.	.	.	C8A	358	0	490	81	0.141856392294221	TRUE	TRUE
ENSG00000143520.6	.	BCM	GRCh38.p13	chr1	152356258	152356258	+	A	A	G	Missense_Mutation	SNP	ENST00000388718.5	exon3	c.T1528C	p.S510P	exonic	ENSG00000143520.6	.	nonsynonymous SNV	ENSG00000143520.6:ENST00000388718.5:exon3:c.T1528C:p.S510P	1q21.3	C3N-03839	.	.	.	.	.	.	.	.	.	4.19	T	D	D	P	.	N	M	T	D	0.081	T	T	T	0.037	0.282	0.292	0.029	T	T	T	T	T	T	1.826	17.920	0.814	N	N	-0.257	1.722	-0.496	1.208	0.001	0.487	0.574	0.574	0.564	.	4.380	1.930	0.221	0.232	0.632	0.000	0.000	0.003	565	.	.	.	.	FLG2	494	0	635	113	0.151069518716578	TRUE	TRUE
ENSG00000162779.22	.	BCM	GRCh38.p13	chr1	179411220	179411220	+	C	C	T	Missense_Mutation	SNP	ENST00000367618.8	exon12	c.C1184T	p.A395V	exonic	ENSG00000162779.22	.	nonsynonymous SNV	ENSG00000162779.22:ENST00000367618.8:exon12:c.C1184T:p.A395V	1q25.2	C3N-03839	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.228	T	T	T	0.024	0.158	0.264	0.027	T	T	T	T	T	T	1.475	15.580	0.971	N	N	-0.597	0.993	-0.611	1.029	0.000	0.554	0.588	0.547	0.564	.	5.180	1.870	0.028	0.929	0.549	0.000	0.968	0.906	545	.	.	.	.	AXDND1	265	0	352	62	0.14975845410628	TRUE	TRUE
ENSG00000143878.10	.	BCM	GRCh38.p13	chr2	20447506	20447506	+	G	G	T	Missense_Mutation	SNP	ENST00000272233.6	exon1	c.G41T	p.G14V	exonic	ENSG00000143878.10	.	nonsynonymous SNV	ENSG00000143878.10:ENST00000272233.6:exon1:c.G41T:p.G14V	2p24.1	C3N-03839	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	U	D	M	T	D	0.568	D	D	D	0.872	0.910	0.933	3.099	D	D	D	D	D	T	4.286	29.500	0.997	D	D	0.753	7.937	0.665	7.145	1.000	0.685	0.749	0.674	0.562	.	5.720	4.840	7.935	1.166	0.665	1.000	1.000	0.998	431	Small_GTP-binding_protein_domain	.	.	.	RHOB	146	0	172	32	0.156862745098039	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178776609	178776609	+	C	C	T	Missense_Mutation	SNP	ENST00000591111.5	exon28	c.G5255A	p.R1752H	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon28:c.G5255A:p.R1752H	2q31.2	C3N-03839	0.0002	0	0.0018	0	0	4.499e-05	0	6.058e-05	rs150737838	10.17	D	D	D	D	.	D	.	T	D	0.713	T	T	D	0.521	.	0.397	0.516	T	.	T	T	T	D	3.254	24.000	0.967	D	D	0.611	6.040	0.608	6.326	1.000	0.487	0.545	0.574	0.542	.	5.050	5.050	4.941	0.071	-0.189	1.000	0.985	0.979	345	Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV59901601;OCCURENCE=1(breast),1(pancreas)	TTN	262	0	295	55	0.157142857142857	TRUE	TRUE
ENSG00000115677.17	.	BCM	GRCh38.p13	chr2	241235491	241235491	+	T	T	A	Missense_Mutation	SNP	ENST00000391975.5	exon22	c.A3008T	p.E1003V	exonic	ENSG00000115677.17	.	nonsynonymous SNV	ENSG00000115677.17:ENST00000391975.5:exon22:c.A3008T:p.E1003V	2q37.3	C3N-03839	.	.	.	.	.	.	.	.	.	12.16	D	D	.	.	D	D	.	T	D	0.904	T	T	D	0.491	0.749	0.290	0.956	T	.	D	D	D	D	6.441	36	0.992	D	D	0.759	8.028	0.717	8.093	1.000	0.722	0.702	0.702	0.735	.	5.790	5.790	7.953	1.138	0.665	1.000	0.989	0.972	994	K_Homology_domain,_type_1;K_Homology_domain	.	.	.	HDLBP	79	0	120	35	0.225806451612903	TRUE	TRUE
ENSG00000168036.18	.	BCM	GRCh38.p13	chr3	41225374	41225374	+	C	C	A	Missense_Mutation	SNP	ENST00000349496.11	exon5	c.C536A	p.S179Y	exonic	ENSG00000168036.18	.	nonsynonymous SNV	ENSG00000168036.18:ENST00000349496.11:exon5:c.C536A:p.S179Y	3p22.1	C3N-03839	.	.	.	.	.	.	.	.	rs77624106	17.20	D	D	D	D	D	D	M	T	D	0.911	T	T	D	0.692	0.486	0.949	2.551	D	D	D	D	D	D	3.909	26.400	0.995	D	D	0.903	11.140	0.882	12.996	1.000	0.722	0.725	0.699	0.711	.	5.700	5.700	7.905	1.026	0.597	1.000	1.000	1.000	679	.	.	.	.	CTNNB1	408	0	363	105	0.224358974358974	TRUE	NA
ENSG00000008300.17	.	BCM	GRCh38.p13	chr3	48650906	48650906	+	G	G	T	Missense_Mutation	SNP	ENST00000164024.5	exon15	c.C6356A	p.A2119D	exonic	ENSG00000008300.17	.	nonsynonymous SNV	ENSG00000008300.17:ENST00000164024.5:exon15:c.C6356A:p.A2119D	3p21.31	C3N-03839	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	.	D	L	T	N	0.490	T	T	T	0.122	0.696	0.471	0.517	T	T	T	T	T	T	2.394	22.100	0.975	D	N	-0.109	2.148	0.029	2.462	0.997	0.696	0.547	0.723	0.563	.	5.050	4.170	3.151	1.176	0.676	1.000	1.000	0.998	4	GPCR,_family_2,_extracellular_hormone_receptor_domain;Laminin_EGF_domain	.	.	.	CELSR3	243	0	279	89	0.241847826086957	TRUE	TRUE
ENSG00000158258.16	.	BCM	GRCh38.p13	chr3	140466669	140466669	+	C	C	T	Missense_Mutation	SNP	ENST00000458420.7	exon8	c.C1282T	p.R428W	exonic	ENSG00000158258.16	.	nonsynonymous SNV	ENSG00000158258.16:ENST00000458420.7:exon8:c.C1282T:p.R428W	3q23	C3N-03839	8.242e-06	0	0	0	0	1.499e-05	0	0	rs765719211	15.20	T	T	D	D	D	D	M	T	D	0.965	T	T	D	0.562	0.685	0.818	0.431	D	D	D	D	D	D	3.321	24.200	0.994	D	D	0.315	3.860	0.269	3.540	0.995	0.554	0.590	0.618	0.564	.	5.200	2.220	1.307	1.026	0.599	1.000	1.000	0.999	882	.	.	.	ID=COSV71720759;OCCURENCE=2(large_intestine)	CLSTN2	379	0	577	89	0.133633633633634	TRUE	TRUE
ENSG00000152580.8	.	BCM	GRCh38.p13	chr3	151453575	151453575	+	G	G	T	Missense_Mutation	SNP	ENST00000282466.3	exon3	c.C524A	p.S175Y	exonic	ENSG00000152580.8	.	nonsynonymous SNV	ENSG00000152580.8:ENST00000282466.3:exon3:c.C524A:p.S175Y	3q25.1	C3N-03839	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.623	T	T	D	0.393	0.541	0.861	0.195	T	T	T	T	D	T	3.877	26.200	0.995	D	D	0.909	11.286	0.857	12.046	1.000	0.554	0.590	0.602	0.542	.	5.150	5.150	9.602	1.176	0.676	1.000	0.994	0.987	813	.	.	.	.	IGSF10	186	0	213	55	0.205223880597015	TRUE	TRUE
ENSG00000088926.14	.	BCM	GRCh38.p13	chr4	186274274	186274274	+	C	C	T	Missense_Mutation	SNP	ENST00000403665.7	exon5	c.C484T	p.R162C	exonic	ENSG00000088926.14	.	nonsynonymous SNV	ENSG00000088926.14:ENST00000403665.7:exon5:c.C484T:p.R162C	4q35.2	C3N-03839	1.649e-05	0	8.648e-05	0	0	1.499e-05	0	0	rs748139184	18.20	D	D	D	P	D	D	M	D	D	0.434	D	D	D	0.783	0.928	0.976	0.154	T	D	D	D	D	D	4.339	29.900	0.999	D	D	0.684	6.900	0.641	6.784	1.000	0.554	0.574	0.618	0.564	.	5.760	5.760	2.620	1.026	0.599	1.000	0.697	0.720	582	Apple_domain;PAN/Apple_domain	.	.	.	F11	470	0	590	104	0.14985590778098	TRUE	NA
ENSG00000164509.15	.	BCM	GRCh38.p13	chr5	55916821	55916821	+	G	G	A	Missense_Mutation	SNP	ENST00000652347.1	exon15	c.G1996A	p.G666R	exonic	ENSG00000164509.15	.	nonsynonymous SNV	ENSG00000164509.15:ENST00000652347.1:exon15:c.G1996A:p.G666R	5q11.2	C3N-03839	8.239e-06	0	0	0	0	0	0	6.056e-05	rs765709220	8.18	D	D	D	D	N	D	.	T	D	0.349	T	T	T	0.220	0.227	0.710	0.536	T	.	T	T	D	T	3.598	25.000	0.999	D	N	0.647	6.444	0.636	6.711	1.000	0.615	0.547	0.547	0.655	.	5.650	5.650	3.333	1.176	0.676	1.000	0.839	0.956	907	.	.	.	.	IL31RA	520	0	752	120	0.137614678899083	TRUE	TRUE
ENSG00000151292.17	.	BCM	GRCh38.p13	chr5	123614379	123614379	+	A	A	C	Missense_Mutation	SNP	ENST00000361991.6	exon12	c.A1327C	p.I443L	exonic	ENSG00000151292.17	.	nonsynonymous SNV	ENSG00000151292.17:ENST00000361991.6:exon12:c.A1327C:p.I443L	5q23.2	C3N-03839	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	N	T	N	0.279	T	T	T	0.094	0.145	0.182	.	T	T	T	T	D	D	1.369	14.870	0.923	D	N	-0.312	1.584	-0.101	2.044	1.000	0.745	0.732	0.710	0.714	.	4.950	4.950	2.113	1.312	0.756	0.981	1.000	0.997	931	.	.	.	.	CSNK1G3	139	0	191	26	0.119815668202765	TRUE	TRUE
ENSG00000152377.14	.	BCM	GRCh38.p13	chr5	137498518	137498518	+	C	C	A	Missense_Mutation	SNP	ENST00000394945.6	exon2	c.G41T	p.W14L	exonic	ENSG00000152377.14	.	nonsynonymous SNV	ENSG00000152377.14:ENST00000394945.6:exon2:c.G41T:p.W14L	5q31.2	C3N-03839	.	.	.	.	.	.	.	.	.	7.20	T	D	P	P	N	N	L	T	D	0.596	T	T	D	0.199	0.550	0.364	1.110	D	T	T	T	D	T	3.334	24.200	0.982	D	D	0.223	3.405	0.182	3.098	1.000	0.685	0.590	0.674	0.562	.	3.510	3.510	4.357	0.929	0.596	1.000	0.997	0.860	45	.	.	.	.	SPOCK1	179	0	277	50	0.152905198776758	TRUE	TRUE
ENSG00000182700.5	.	BCM	GRCh38.p13	chr5	140128568	140128585	+	AATCACCATGTGGAAACC	AATCACCATGTGGAAACC	-	In_Frame_Del	DEL	ENST00000333305.5	exon1	c.92_109del	p.S32_Q37del	exonic	ENSG00000182700.5	.	nonframeshift deletion	ENSG00000182700.5:ENST00000333305.5:exon1:c.92_109del:p.S32_Q37del	5q31.3	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGIP	327	0	449	57	0.112648221343874	TRUE	TRUE
ENSG00000011083.9	.	BCM	GRCh38.p13	chr5	150196744	150196744	+	G	G	A	Missense_Mutation	SNP	ENST00000230671.7	exon3	c.G246A	p.M82I	exonic	ENSG00000011083.9	.	nonsynonymous SNV	ENSG00000011083.9:ENST00000230671.7:exon3:c.G246A:p.M82I	5q32	C3N-03839	.	.	.	.	.	.	.	.	.	13.20	D	D	P	P	D	D	M	T	D	0.885	D	T	D	0.617	0.556	0.859	0.626	D	T	T	T	D	D	3.536	24.800	0.998	D	D	0.563	5.568	0.566	5.826	0.997	0.516	0.610	0.547	0.542	.	5.320	4.440	6.911	0.190	0.676	1.000	0.989	0.998	779	.	.	.	.	SLC6A7	195	0	365	83	0.185267857142857	TRUE	NA
ENSG00000232040.4	.	BCM	GRCh38.p13	chr6	28572094	28572094	+	T	T	G	Missense_Mutation	SNP	ENST00000452236.3	exon4	c.A3795C	p.L1265F	exonic	ENSG00000232040.4	.	nonsynonymous SNV	ENSG00000232040.4:ENST00000452236.3:exon4:c.A3795C:p.L1265F	6p22.1	C3N-03839	8.252e-06	0	0	0	0	1.5e-05	0	0	rs757920531	4.20	D	D	P	P	U	N	M	T	N	0.348	T	T	T	0.145	0.444	0.471	1.159	T	T	T	T	D	T	2.645	22.700	0.998	N	N	0.186	3.244	0.034	2.481	0.393	0.615	0.588	0.659	0.542	.	2.530	1.360	0.758	0.970	0.665	1.000	0.983	0.869	680	.	.	.	.	ZBED9	357	0	390	102	0.207317073170732	TRUE	NA
ENSG00000204290.10	.	BCM	GRCh38.p13	chr6	32394807	32394807	+	C	C	T	Missense_Mutation	SNP	ENST00000374993.4	exon6	c.G1297A	p.V433I	exonic	ENSG00000204290.10	.	nonsynonymous SNV	ENSG00000204290.10:ENST00000374993.4:exon6:c.G1297A:p.V433I	6p21.32	C3N-03839	8.238e-06	0	0	0	0	1.499e-05	0	0	rs376819015	2.19	D	T	P	P	D	N	L	T	N	0.177	T	T	T	0.168	.	0.136	0.542	T	T	T	T	T	.	2.107	20.200	0.988	N	N	-0.534	1.110	-0.635	0.994	1.000	0.428	0.547	0.547	0.646	.	4.930	4.070	-0.078	0.952	0.537	0.008	0.165	0.048	934	.	.	.	ID=COSV66630366;OCCURENCE=2(haematopoietic_and_lymphoid_tissue)	BTNL2	154	0	466	52	0.1003861003861	TRUE	TRUE
ENSG00000187189.11	.	BCM	GRCh38.p13	chr6	116253921	116253921	+	G	G	A	Nonsense_Mutation	SNP	ENST00000420283.3	exon1	c.C88T	p.R30X	exonic	ENSG00000187189.11	.	stopgain	ENSG00000187189.11:ENST00000420283.3:exon1:c.C88T:p.R30X	6q22.1	C3N-03839	.	.	.	.	.	.	.	.	rs75652959	3.5	.	.	.	.	.	D	.	.	.	0.080	.	.	.	.	.	.	.	.	.	D	D	.	.	4.759	32	0.994	N	N	0.039	2.651	-0.337	1.491	1.000	0.442	0.522	0.522	0.562	.	4.300	-0.947	-0.269	-0.236	-0.208	0.000	0.002	0.106	559	.	.	.	.	TSPYL4	102	0	117	24	0.170212765957447	TRUE	TRUE
ENSG00000197343.11	.	BCM	GRCh38.p13	chr7	99572707	99572707	+	A	A	G	Missense_Mutation	SNP	ENST00000252713.9	exon3	c.A599G	p.N200S	exonic	ENSG00000197343.11	.	nonsynonymous SNV	ENSG00000197343.11:ENST00000252713.9:exon3:c.A599G:p.N200S	7q22.1	C3N-03839	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.028	T	T	T	0.016	0.214	0.014	0.138	T	T	T	T	T	T	-0.395	0.197	0.271	N	N	-1.314	0.157	-1.372	0.166	0.004	0.707	0.725	0.576	0.636	.	4.780	-4.670	-1.048	0.094	0.756	0.000	0.799	0.730	273	.	.	.	.	ZNF655	197	0	294	58	0.164772727272727	NA	TRUE
ENSG00000104320.14	.	BCM	GRCh38.p13	chr8	89958854	89958854	+	C	C	A	Missense_Mutation	SNP	ENST00000265433.8	exon9	c.G995T	p.G332V	exonic	ENSG00000104320.14	.	nonsynonymous SNV	ENSG00000104320.14:ENST00000265433.8:exon9:c.G995T:p.G332V	8q21.3	C3N-03839	.	.	.	.	.	.	.	.	.	5.20	D	T	B	B	N	D	M	T	N	0.290	T	T	T	0.073	0.150	0.744	0.218	T	T	T	T	D	T	2.767	23.000	0.976	D	N	-0.228	1.799	-0.198	1.791	0.989	0.732	0.725	0.744	0.714	.	5.850	2.010	0.671	-0.251	0.599	0.571	0.729	0.722	889	.	.	.	.	NBN	360	0	460	133	0.224283305227656	TRUE	TRUE
ENSG00000132549.18	.	BCM	GRCh38.p13	chr8	99861901	99861901	+	G	G	A	Missense_Mutation	SNP	ENST00000358544.6	exon58	c.G11245A	p.E3749K	exonic	ENSG00000132549.18	.	nonsynonymous SNV	ENSG00000132549.18:ENST00000358544.6:exon58:c.G11245A:p.E3749K	8q22.2	C3N-03839	6.099e-05	0	0	0.0003	0	7.671e-05	0	0	rs180177372	11.20	D	D	D	P	D	D	L	T	N	0.643	T	T	D	0.452	.	0.795	0.396	T	T	D	D	T	D	4.087	27.600	0.999	D	D	0.740	7.720	0.770	9.297	1.000	0.706	0.710	0.616	0.492	.	5.790	5.790	7.333	1.176	0.676	1.000	0.968	0.954	458	.	.	.	.	VPS13B	284	0	350	139	0.284253578732106	TRUE	NA
ENSG00000164796.18	.	BCM	GRCh38.p13	chr8	112311130	112311130	+	C	C	G	Missense_Mutation	SNP	ENST00000297405.10	exon50	c.G7733C	p.G2578A	exonic	ENSG00000164796.18	.	nonsynonymous SNV	ENSG00000164796.18:ENST00000297405.10:exon50:c.G7733C:p.G2578A	8q23.3	C3N-03839	.	.	.	.	.	.	.	.	.	17.20	D	T	D	D	D	D	M	T	D	0.964	D	D	D	0.732	0.851	0.756	0.685	D	T	D	D	D	D	4.207	28.700	0.998	D	D	1.019	14.533	0.957	16.451	1.000	0.554	0.574	0.574	0.621	.	5.760	5.760	7.902	1.026	0.599	1.000	1.000	0.995	853	Sushi/SCR/CCP_domain	.	.	.	CSMD3	363	0	487	185	0.275297619047619	TRUE	TRUE
ENSG00000119121.22	.	BCM	GRCh38.p13	chr9	74840053	74840053	+	G	G	A	Missense_Mutation	SNP	ENST00000360774.6	exon5	c.C515T	p.A172V	exonic	ENSG00000119121.22	.	nonsynonymous SNV	ENSG00000119121.22:ENST00000360774.6:exon5:c.C515T:p.A172V	9q21.13	C3N-03839	8.237e-06	0	8.637e-05	0	0	0	0	0	rs202053435	16.20	D	D	D	D	D	D	M	T	D	0.931	T	T	D	0.592	0.478	0.495	0.896	T	D	D	D	D	D	3.663	25.300	0.999	D	D	0.976	13.186	0.934	15.273	0.999	0.554	0.574	0.602	0.564	.	5.860	5.860	8.062	1.172	0.672	1.000	0.889	0.848	647	.	.	.	ID=COSV62506882;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	TRPM6	439	0	566	128	0.184438040345821	TRUE	TRUE
ENSG00000165181.16	.	BCM	GRCh38.p13	chr9	111699974	111699974	+	A	A	G	Missense_Mutation	SNP	ENST00000374287.7	exon21	c.T2971C	p.S991P	exonic	ENSG00000165181.16	.	nonsynonymous SNV	ENSG00000165181.16:ENST00000374287.7:exon21:c.T2971C:p.S991P	9q31.3	C3N-03839	.	.	.	.	.	.	.	.	.	3.15	T	T	.	.	N	D	.	T	N	0.268	T	T	T	0.034	0.294	0.291	0.198	.	.	T	T	D	T	3.002	23.400	0.995	D	N	-0.141	2.048	0.015	2.410	0.358	0.487	0.574	0.574	0.613	.	6.080	3.630	2.246	1.288	0.756	1.000	0.970	0.954	364	.	.	.	.	SHOC1	198	0	272	33	0.108196721311475	TRUE	TRUE
ENSG00000050555.18	.	BCM	GRCh38.p13	chr9	131041729	131041729	+	G	G	A	Missense_Mutation	SNP	ENST00000361069.9	exon7	c.G1376A	p.C459Y	exonic	ENSG00000050555.18	.	nonsynonymous SNV	ENSG00000050555.18:ENST00000361069.9:exon7:c.G1376A:p.C459Y	9q34.12	C3N-03839	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	D	D	0.993	D	D	D	0.974	0.875	0.968	0.842	T	T	D	D	D	D	4.062	27.400	0.998	D	D	1.021	14.605	0.882	13.020	1.000	0.706	0.547	0.710	0.639	.	4.970	4.970	9.877	1.175	0.676	1.000	0.923	0.280	427	Laminin_EGF_domain	.	.	.	LAMC3	716	1	966	179	0.156331877729258	TRUE	TRUE
ENSG00000197859.11	.	BCM	GRCh38.p13	chr9	133570400	133570400	+	C	C	T	Missense_Mutation	SNP	ENST00000651351.2	exon17	c.C2485T	p.P829S	exonic	ENSG00000197859.11	.	nonsynonymous SNV	ENSG00000197859.11:ENST00000651351.2:exon17:c.C2485T:p.P829S	9q34.2	C3N-03839	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	U	N	N	T	N	0.178	T	T	T	0.018	0.260	0.606	0.526	T	T	T	T	D	T	2.379	22.000	0.978	D	N	-0.488	1.201	-0.319	1.526	0.005	0.554	0.588	0.604	0.613	.	3.800	2.860	2.850	1.026	0.599	1.000	0.983	0.951	778	.	.	.	.	ADAMTSL2	409	0	551	106	0.161339421613394	TRUE	TRUE
ENSG00000177354.12	.	BCM	GRCh38.p13	chr10	49326726	49326726	+	C	C	T	Missense_Mutation	SNP	ENST00000374144.8	exon3	c.C4181T	p.P1394L	exonic	ENSG00000177354.12	.	nonsynonymous SNV	ENSG00000177354.12:ENST00000374144.8:exon3:c.C4181T:p.P1394L	10q11.23	C3N-03839	.	.	.	.	.	.	.	.	rs565274702	0.15	T	T	.	.	U	N	.	T	N	0.051	T	T	T	0.017	0.215	0.076	0.237	.	.	T	T	T	T	-0.881	0.016	0.708	N	N	-1.354	0.137	-1.486	0.113	0.969	0.487	0.590	0.547	0.564	.	5.320	-5.690	-0.641	-1.042	-2.505	0.000	0.000	0.002	894	.	.	.	ID=COSV60510894;OCCURENCE=1(large_intestine)	C10orf71	411	0	607	115	0.159279778393352	TRUE	TRUE
ENSG00000185933.7	.	BCM	GRCh38.p13	chr10	103458211	103458211	+	G	G	A	Missense_Mutation	SNP	ENST00000329905.6	exon1	c.C541T	p.R181C	exonic	ENSG00000185933.7	.	nonsynonymous SNV	ENSG00000185933.7:ENST00000329905.6:exon1:c.C541T:p.R181C	10q24.33	C3N-03839	8.494e-06	0	8.723e-05	0	0	0	0	0	rs769331766	11.20	D	D	D	P	N	D	M	T	D	0.657	T	T	D	0.351	0.648	0.300	0.690	T	T	T	T	D	D	4.413	31	0.999	D	D	0.739	7.694	0.721	8.157	1.000	0.554	0.588	0.578	0.563	.	5.490	5.490	7.094	1.097	0.586	1.000	0.998	0.984	267	.	.	.	.	CALHM1	384	0	510	88	0.147157190635452	TRUE	NA
ENSG00000006071.15	.	BCM	GRCh38.p13	chr11	17461735	17461735	+	G	G	T	Missense_Mutation	SNP	ENST00000389817.8	exon5	c.C670A	p.L224M	exonic	ENSG00000006071.15	.	nonsynonymous SNV	ENSG00000006071.15:ENST00000389817.8:exon5:c.C670A:p.L224M	11p15.1	C3N-03839	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	N	0.687	D	D	D	0.769	0.527	0.951	0.888	D	D	D	D	D	D	3.209	23.900	0.997	D	D	0.532	5.291	0.463	4.843	1.000	0.554	0.590	0.602	0.542	.	5.600	3.730	1.233	0.224	0.676	1.000	0.998	0.998	739	.	.	.	.	ABCC8	571	0	775	170	0.17989417989418	TRUE	TRUE
ENSG00000110076.19	.	BCM	GRCh38.p13	chr11	64685669	64685669	+	G	G	A	Missense_Mutation	SNP	ENST00000265459.11	exon6	c.C1129T	p.R377W	exonic	ENSG00000110076.19	.	nonsynonymous SNV	ENSG00000110076.19:ENST00000265459.11:exon6:c.C1129T:p.R377W	11q13.1	C3N-03839	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	U	D	M	T	D	0.732	D	D	D	0.701	0.556	0.955	1.106	D	D	D	D	D	D	4.010	27.000	0.999	D	D	0.381	4.230	0.292	3.669	0.990	0.615	0.610	0.659	0.542	.	4.000	3.060	1.705	1.176	0.618	0.983	1.000	0.997	382	Laminin_G_domain	.	.	ID=COSV55454599;OCCURENCE=1(liver),1(large_intestine)	NRXN2	698	0	874	167	0.160422670509126	TRUE	TRUE
ENSG00000077616.11	.	BCM	GRCh38.p13	chr11	90152384	90152384	+	T	T	A	Nonsense_Mutation	SNP	ENST00000534061.6	exon6	c.T696A	p.Y232X	exonic	ENSG00000077616.11	.	stopgain	ENSG00000077616.11:ENST00000534061.6:exon6:c.T696A:p.Y232X	11q14.3	C3N-03839	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.570	.	.	.	.	.	.	.	.	.	D	D	.	.	6.255	35	0.996	D	N	0.626	6.204	0.397	4.340	0.000	0.693	0.574	0.659	0.621	.	5.220	0.166	0.220	0.200	0.660	0.990	0.996	0.998	915	PA_domain	.	.	.	NAALAD2	97	0	174	25	0.125628140703518	TRUE	TRUE
ENSG00000137674.4	.	BCM	GRCh38.p13	chr11	102593540	102593540	+	A	A	C	Missense_Mutation	SNP	ENST00000260228.3	exon8	c.T1146G	p.I382M	exonic	ENSG00000137674.4	.	nonsynonymous SNV	ENSG00000137674.4:ENST00000260228.3:exon8:c.T1146G:p.I382M	11q22.2	C3N-03839	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	M	T	D	0.552	T	T	T	0.325	0.738	0.614	0.266	T	T	T	T	D	T	3.167	23.800	0.996	D	N	0.211	3.351	0.082	2.661	0.982	0.554	0.588	0.547	0.584	.	5.060	1.440	0.593	0.307	-0.089	1.000	0.982	0.840	778	Hemopexin-like_domain	.	.	.	MMP20	291	0	402	77	0.160751565762004	TRUE	TRUE
ENSG00000154134.15	.	BCM	GRCh38.p13	chr11	124880445	124880445	+	C	C	T	Missense_Mutation	SNP	ENST00000397801.6	exon27	c.C3986T	p.P1329L	exonic	ENSG00000154134.15	.	nonsynonymous SNV	ENSG00000154134.15:ENST00000397801.6:exon27:c.C3986T:p.P1329L	11q24.2	C3N-03839	.	.	.	.	.	.	.	.	.	11.20	D	D	B	B	N	D	M	T	D	0.385	T	T	D	0.136	0.288	0.798	0.474	T	D	T	T	D	D	2.619	22.700	0.998	D	D	-0.029	2.408	0.063	2.588	1.000	0.675	0.590	0.693	0.696	.	5.620	4.710	3.672	1.026	0.599	0.986	0.436	0.327	712	.	.	.	.	ROBO3	337	0	484	97	0.166953528399312	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-03839	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	366	0	442	91	0.170731707317073	TRUE	TRUE
ENSG00000135503.13	.	BCM	GRCh38.p13	chr12	51986924	51986924	+	C	C	T	Nonsense_Mutation	SNP	ENST00000257963.9	exon7	c.C1243T	p.R415X	exonic	ENSG00000135503.13	.	stopgain	ENSG00000135503.13:ENST00000257963.9:exon7:c.C1243T:p.R415X	12q13.13	C3N-03839	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.943	.	.	.	.	.	.	.	.	.	D	D	.	.	7.821	39	0.998	D	N	0.809	8.967	0.672	7.264	1.000	0.732	0.610	0.744	0.714	.	4.770	4.770	2.613	1.026	0.597	0.981	0.994	0.995	628	Protein_kinase_domain	.	.	.	ACVR1B	623	0	645	152	0.190715181932246	TRUE	TRUE
ENSG00000198812.5	.	BCM	GRCh38.p13	chr12	69610715	69610715	+	G	G	A	Missense_Mutation	SNP	ENST00000361484.5	exon1	c.C124T	p.R42C	exonic	ENSG00000198812.5	.	nonsynonymous SNV	ENSG00000198812.5:ENST00000361484.5:exon1:c.C124T:p.R42C	12q15	C3N-03839	8.302e-06	0	0	0	0	1.508e-05	0	0	rs768421373	11.20	D	D	B	B	D	D	M	T	D	0.247	T	T	D	0.123	0.456	0.427	0.292	T	D	T	T	D	T	2.901	23.200	0.999	D	D	-0.079	2.242	0.004	2.374	0.997	0.487	0.574	0.547	0.542	.	5.620	4.710	2.418	0.224	0.676	0.998	0.407	0.250	799	.	.	.	ID=COSV100825446;OCCURENCE=1(large_intestine)	LRRC10	285	0	378	74	0.163716814159292	TRUE	TRUE
ENSG00000179104.9	.	BCM	GRCh38.p13	chr12	82896430	82896430	+	G	G	A	Missense_Mutation	SNP	ENST00000321196.8	exon3	c.G1267A	p.V423I	exonic	ENSG00000179104.9	.	nonsynonymous SNV	ENSG00000179104.9:ENST00000321196.8:exon3:c.G1267A:p.V423I	12q21.31	C3N-03839	8.238e-06	0	0	0	0	1.499e-05	0	0	rs760933625	7.20	T	T	D	P	D	D	L	T	N	0.650	T	T	T	0.161	0.414	0.281	0.240	T	T	T	T	D	D	2.911	23.200	0.999	D	D	0.653	6.504	0.723	8.216	1.000	0.615	0.588	0.618	0.655	.	5.860	5.860	9.602	1.176	0.676	1.000	0.998	0.999	793	.	.	.	ID=COSV58262981;OCCURENCE=1(large_intestine)	TMTC2	277	0	347	62	0.15158924205379	TRUE	TRUE
ENSG00000135108.14	.	BCM	GRCh38.p13	chr12	117190392	117190392	+	G	G	T	Missense_Mutation	SNP	ENST00000330622.9	exon1	c.C65A	p.P22Q	exonic	ENSG00000135108.14	.	nonsynonymous SNV	ENSG00000135108.14:ENST00000330622.9:exon1:c.C65A:p.P22Q	12q24.22	C3N-03839	.	.	.	.	.	.	.	.	.	3.20	D	T	P	B	N	N	N	T	N	0.203	T	T	D	0.067	0.264	0.348	0.436	T	T	T	T	T	T	3.136	23.700	0.942	D	N	-0.125	2.098	-0.086	2.087	1.000	0.442	0.522	0.522	0.562	.	3.760	3.760	2.935	1.154	0.590	0.991	0.966	0.979	934	.	.	.	.	FBXO21	204	0	334	66	0.165	TRUE	NA
ENSG00000102595.20	.	BCM	GRCh38.p13	chr13	95970236	95970236	+	C	C	T	Missense_Mutation	SNP	ENST00000376747.8	exon12	c.G1211A	p.G404E	exonic	ENSG00000102595.20	.	nonsynonymous SNV	ENSG00000102595.20:ENST00000376747.8:exon12:c.G1211A:p.G404E	13q32.1	C3N-03839	1.654e-05	0	0	0	0.0002	1.501e-05	0	0	rs780935476	8.20	D	T	B	B	D	D	M	T	D	0.720	T	T	T	0.114	0.598	0.511	0.386	T	T	T	T	D	T	2.881	23.200	0.997	D	D	0.163	3.145	0.294	3.684	0.983	0.615	0.588	0.618	0.655	.	5.450	5.450	4.127	1.026	0.599	1.000	1.000	0.999	940	.	.	.	.	UGGT2	187	0	209	39	0.157258064516129	TRUE	NA
ENSG00000070182.21	.	BCM	GRCh38.p13	chr14	64771032	64771032	+	G	G	A	Missense_Mutation	SNP	ENST00000389720.4	exon27	c.C5651T	p.A1884V	exonic	ENSG00000070182.21	.	nonsynonymous SNV	ENSG00000070182.21:ENST00000389720.4:exon27:c.C5651T:p.A1884V	14q23.3	C3N-03839	0.0016	0.0004	0.0011	0	0.0009	0.0019	0.0022	0.0027	rs148337824	13.20	D	D	D	D	D	D	M	T	D	0.746	T	T	T	0.498	.	0.670	0.583	T	D	T	D	T	D	2.364	21.900	0.996	D	D	-0.203	1.868	-0.323	1.518	1.000	0.701	0.549	0.717	0.542	.	5.140	4.240	5.851	-0.124	-0.104	1.000	0.112	0.012	448	.	.	.	ID=COSV67632313;OCCURENCE=1(large_intestine)	SPTB	545	1	694	157	0.18448883666275	TRUE	TRUE
ENSG00000133958.13	.	BCM	GRCh38.p13	chr14	93542515	93542515	+	G	G	A	Missense_Mutation	SNP	ENST00000393151.6	exon14	c.G1574A	p.R525Q	exonic	ENSG00000133958.13	.	nonsynonymous SNV	ENSG00000133958.13:ENST00000393151.6:exon14:c.G1574A:p.R525Q	14q32.12	C3N-03839	1.66e-05	0	0	0	0	3.013e-05	0	0	rs200477456	9.17	D	D	.	.	D	D	L	T	D	0.821	T	T	T	0.301	.	0.219	2.295	T	D	T	T	D	.	4.190	28.600	1.000	D	D	0.672	6.742	0.692	7.609	1.000	0.554	0.574	0.602	0.613	.	5.810	4.920	9.705	1.176	0.676	1.000	0.997	0.991	851	.	.	.	ID=COSV99825931;OCCURENCE=1(stomach),1(endometrium)	UNC79	371	0	442	95	0.176908752327747	TRUE	NA
ENSG00000203485.13	.	BCM	GRCh38.p13	chr14	104711650	104711650	+	G	G	A	Missense_Mutation	SNP	ENST00000392634.9	exon16	c.G2440A	p.D814N	exonic	ENSG00000203485.13	.	nonsynonymous SNV	ENSG00000203485.13:ENST00000392634.9:exon16:c.G2440A:p.D814N	14q32.33	C3N-03839	4.211e-05	0	0	0	0	6.127e-05	0	6.067e-05	rs373532334	13.20	D	D	D	D	D	D	M	T	D	0.281	T	T	D	0.287	.	0.459	0.241	T	T	T	T	D	D	3.294	24.100	0.996	D	D	0.588	5.803	0.466	4.860	1.000	0.706	0.710	0.723	0.714	.	4.170	4.170	5.232	1.176	0.618	1.000	0.798	0.191	957	Formin,_FH2_domain	.	.	.	INF2	271	0	407	74	0.153846153846154	TRUE	NA
ENSG00000179455.9	.	BCM	GRCh38.p13	chr15	23566319	23566319	+	C	C	A	Missense_Mutation	SNP	ENST00000314520.6	exon1	c.C537A	p.F179L	exonic	ENSG00000179455.9	.	nonsynonymous SNV	ENSG00000179455.9:ENST00000314520.6:exon1:c.C537A:p.F179L	15q11.2	C3N-03839	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.101	T	T	T	0.080	0.276	0.370	0.076	T	T	T	T	T	T	1.681	16.900	0.741	N	N	-0.945	0.465	-0.928	0.582	1.000	0.487	0.514	0.574	0.651	.	3.990	2.090	-0.015	0.937	0.596	0.000	0.979	0.065	994	.	.	.	.	MKRN3	303	0	379	50	0.116550116550117	TRUE	TRUE
ENSG00000206190.12	.	BCM	GRCh38.p13	chr15	25681035	25681035	+	C	C	T	Missense_Mutation	SNP	ENST00000555815.6	exon18	c.G3532A	p.A1178T	exonic	ENSG00000206190.12	.	nonsynonymous SNV	ENSG00000206190.12:ENST00000555815.6:exon18:c.G3532A:p.A1178T	15q12	C3N-03839	3.295e-05	0	0	0.0002	0	1.498e-05	0	6.056e-05	rs764757185	16.20	D	D	D	D	D	D	M	T	D	0.849	D	D	D	0.639	0.670	0.680	0.177	T	T	T	D	D	D	3.033	23.500	0.998	D	D	0.521	5.204	0.357	4.069	1.000	0.615	0.574	0.659	0.564	.	4.840	4.840	7.651	1.026	0.599	1.000	0.005	0.005	625	P-type_ATPase,_C-terminal	.	.	ID=COSV100790726;OCCURENCE=1(skin),1(endometrium)	ATP10A	317	0	316	99	0.23855421686747	TRUE	NA
ENSG00000140543.14	.	BCM	GRCh38.p13	chr15	88513039	88513039	+	A	A	C	Missense_Mutation	SNP	ENST00000268148.12	exon5	c.T1565G	p.F522C	exonic	ENSG00000140543.14;ENSG00000173867.10	.	nonsynonymous SNV	ENSG00000140543.14:ENST00000268148.12:exon5:c.T1565G:p.F522C,ENSG00000173867.10:ENST00000649547.1:exon6:c.T1565G:p.F522C	15q26.1	C3N-03839	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	M	.	D	0.911	T	T	D	0.593	0.927	0.412	1.084	D	T	D	D	D	D	4.444	31	0.994	D	D	0.785	8.497	0.757	8.971	1.000	0.653	0.634	0.659	0.669	.	6.170	5.050	9.070	1.312	0.756	1.000	1.000	1.000	904	.	.	.	.	DET1	252	0	427	130	0.233393177737882	TRUE	TRUE
ENSG00000140470.14	.	BCM	GRCh38.p13	chr15	99976135	99976135	+	C	C	T	Missense_Mutation	SNP	ENST00000268070.9	exon21	c.G3037A	p.A1013T	exonic	ENSG00000140470.14	.	nonsynonymous SNV	ENSG00000140470.14:ENST00000268070.9:exon21:c.G3037A:p.A1013T	15q26.3	C3N-03839	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.107	T	T	T	0.078	0.680	0.331	0.090	T	T	T	T	T	T	-0.356	0.238	0.897	N	N	-1.137	0.275	-1.197	0.286	1.000	0.657	0.610	0.673	0.564	.	5.280	-4.710	-1.175	-1.306	-0.217	0.000	0.037	0.038	945	.	.	.	.	ADAMTS17	157	0	334	30	0.0824175824175824	TRUE	NA
ENSG00000131652.14	.	BCM	GRCh38.p13	chr16	3026772	3026772	+	C	C	T	Nonsense_Mutation	SNP	ENST00000326266.13	exon8	c.C577T	p.R193X	exonic	ENSG00000131652.14	.	stopgain	ENSG00000131652.14:ENST00000326266.13:exon8:c.C577T:p.R193X	16p13.3	C3N-03839	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.429	.	.	.	.	.	.	.	.	.	D	D	.	.	6.555	36	0.997	D	N	0.457	4.720	0.275	3.572	1.000	0.707	0.725	0.702	0.711	.	5.590	3.540	-0.256	1.026	0.599	0.668	0.746	0.568	721	WD40_repeat,_conserved_site;WD40-repeat-containing_domain	.	.	.	THOC6	130	0	206	37	0.152263374485597	TRUE	NA
ENSG00000078328.21	.	BCM	GRCh38.p13	chr16	7518352	7518352	+	C	C	T	Missense_Mutation	SNP	ENST00000550418.6	exon5	c.C233T	p.A78V	exonic	ENSG00000078328.21	.	nonsynonymous SNV	ENSG00000078328.21:ENST00000550418.6:exon5:c.C233T:p.A78V	16p13.3	C3N-03839	.	.	.	.	.	.	.	.	.	6.20	D	T	P	B	N	D	L	T	N	0.532	T	T	T	0.025	0.347	0.189	0.006	T	T	T	T	D	D	2.974	23.400	0.997	D	D	-0.123	2.102	-0.002	2.352	0.980	0.595	0.574	0.598	0.564	.	4.280	4.280	4.046	1.026	0.599	0.983	0.984	0.876	965	.	.	.	ID=COSV60956442;OCCURENCE=1(cervix),3(large_intestine),1(pancreas)	RBFOX1	75	0	126	11	0.0802919708029197	TRUE	TRUE
ENSG00000179588.9	.	BCM	GRCh38.p13	chr16	88533910	88533910	+	C	C	T	Missense_Mutation	SNP	ENST00000319555.8	exon10	c.C1952T	p.A651V	exonic	ENSG00000179588.9	.	nonsynonymous SNV	ENSG00000179588.9:ENST00000319555.8:exon10:c.C1952T:p.A651V	16q24.2	C3N-03839	0.0012	0	0	0	.	0	0	0.0014	rs749486818	2.20	T	T	P	B	U	N	N	T	N	0.100	T	T	D	0.066	0.244	0.276	1.093	D	T	T	T	T	T	1.526	15.900	0.994	N	N	-0.645	0.908	-0.702	0.897	1.000	0.601	0.597	0.240	0.555	.	3.010	0.664	-0.026	0.626	0.366	0.000	0.001	0.353	969	.	.	.	.	ZFPM1	106	0	165	67	0.288793103448276	TRUE	NA
ENSG00000063015.20	.	BCM	GRCh38.p13	chr17	29005865	29005865	+	C	C	A	Missense_Mutation	SNP	ENST00000317338.17	exon1	c.G5T	p.R2L	exonic	ENSG00000063015.20	.	nonsynonymous SNV	ENSG00000063015.20:ENST00000317338.17:exon1:c.G5T:p.R2L	17q11.2	C3N-03839	0	0	0	0	.	0	0	0	rs531592765	4.19	D	D	B	B	.	N	N	T	N	0.260	T	T	D	0.035	0.327	0.257	0.330	D	T	T	T	T	T	1.507	15.780	0.983	N	N	-0.475	1.225	-0.430	1.319	1.000	0.658	0.578	0.619	0.639	.	5.140	2.090	-0.534	-0.329	-0.292	0.019	0.790	0.589	294	.	.	.	.	SEZ6	348	1	494	100	0.168350168350168	TRUE	NA
ENSG00000206422.2	.	BCM	GRCh38.p13	chr18	7231919	7231919	+	G	G	A	Missense_Mutation	SNP	ENST00000383467.2	exon1	c.G781A	p.A261T	exonic	ENSG00000206422.2	.	nonsynonymous SNV	ENSG00000206422.2:ENST00000383467.2:exon1:c.G781A:p.A261T	18p11.23	C3N-03839	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	L	T	N	0.831	T	T	T	0.205	0.402	0.205	0.379	T	T	T	T	D	D	4.223	28.900	0.999	D	D	0.672	6.742	0.631	6.629	1.000	0.487	0.574	0.574	0.564	.	5.700	5.700	9.597	1.176	0.676	1.000	0.954	0.789	955	.	.	.	ID=COSV67301533;OCCURENCE=1(large_intestine),1(stomach),1(lung)	LRRC30	293	0	279	59	0.174556213017751	TRUE	TRUE
ENSG00000064687.13	.	BCM	GRCh38.p13	chr19	1044725	1044725	+	C	C	T	Missense_Mutation	SNP	ENST00000263094.11	exon11	c.C1196T	p.T399M	exonic	ENSG00000064687.13	.	nonsynonymous SNV	ENSG00000064687.13:ENST00000263094.11:exon11:c.C1196T:p.T399M	19p13.3	C3N-03839	.	.	.	.	.	.	.	.	.	3.19	T	T	P	B	.	N	M	D	N	0.096	T	T	D	0.156	0.432	0.773	0.112	T	T	T	T	T	T	0.248	3.685	0.848	N	N	-0.969	0.438	-1.147	0.330	1.000	0.696	0.654	0.692	0.639	.	4.100	-4.160	-1.989	-1.132	-0.176	0.000	0.000	0.120	988	.	.	.	.	ABCA7	209	0	291	60	0.170940170940171	TRUE	TRUE
ENSG00000115266.11	.	BCM	GRCh38.p13	chr19	1470104	1470104	+	C	C	T	Missense_Mutation	SNP	ENST00000535453.5	exon14	c.C6803T	p.A2268V	exonic	ENSG00000115266.11	.	nonsynonymous SNV	ENSG00000115266.11:ENST00000535453.5:exon14:c.C6803T:p.A2268V	19p13.3	C3N-03839	1.169e-05	0	0	0	0	2.139e-05	0	0	rs777883453	11.19	D	D	B	B	D	D	.	D	N	0.164	D	D	D	0.255	0.288	0.690	1.063	T	T	D	T	D	T	2.056	19.680	0.999	D	N	-0.397	1.390	-0.328	1.508	1.000	0.598	0.541	0.607	0.639	.	4.050	3.010	1.690	0.871	0.509	0.984	0.027	0.965	958	.	.	.	.	APC2	178	0	260	64	0.197530864197531	TRUE	NA
ENSG00000167664.8	.	BCM	GRCh38.p13	chr19	4292604	4292604	+	C	C	A	Nonsense_Mutation	SNP	ENST00000301272.6	exon5	c.G844T	p.E282X	exonic	ENSG00000167664.8	.	stopgain	ENSG00000167664.8:ENST00000301272.6:exon5:c.G844T:p.E282X	19p13.3	C3N-03839	.	.	.	.	.	.	.	.	.	2.5	.	.	.	.	.	N	.	.	.	0.067	.	.	.	.	.	.	.	.	.	D	D	.	.	6.614	36	0.966	N	N	0.078	2.798	-0.356	1.454	0.000	0.554	0.590	0.602	0.542	.	2.050	0.993	0.076	-0.016	0.517	0.000	0.000	0.007	946	.	.	.	.	TMIGD2	215	0	317	43	0.119444444444444	TRUE	TRUE
ENSG00000130544.12	.	BCM	GRCh38.p13	chr19	7083589	7083589	+	G	G	A	Missense_Mutation	SNP	ENST00000414706.2	exon8	c.G1117A	p.D373N	exonic	ENSG00000130544.12	.	nonsynonymous SNV	ENSG00000130544.12:ENST00000414706.2:exon8:c.G1117A:p.D373N	19p13.2	C3N-03839	.	.	.	.	.	.	.	.	.	1.19	T	D	B	B	.	N	L	T	N	0.120	T	T	T	0.046	0.539	0.194	0.358	T	T	T	T	T	T	0.731	8.736	0.984	N	N	-1.477	0.088	-1.594	0.077	0.670	0.461	0.553	0.487	0.636	.	1.320	-2.630	-0.794	-0.604	-0.704	0.000	0.332	0.006	946	Zinc_finger_C2H2-type	.	.	.	ZNF557	242	0	377	56	0.12933025404157	TRUE	TRUE
ENSG00000142347.19	.	BCM	GRCh38.p13	chr19	8554679	8554679	+	C	C	T	Missense_Mutation	SNP	ENST00000644032.2	exon3	c.G206A	p.R69H	exonic	ENSG00000142347.19	.	nonsynonymous SNV	ENSG00000142347.19:ENST00000644032.2:exon3:c.G206A:p.R69H	19p13.2	C3N-03839	5.798e-05	0	0.0003	0.0002	0.0002	0	0	6.056e-05	rs778366731	14.20	D	D	D	D	D	D	L	D	D	0.432	D	D	D	0.429	0.364	0.850	1.612	T	D	T	T	T	D	3.405	24.400	1.000	D	N	0.281	3.685	0.297	3.700	0.999	0.707	0.725	0.659	0.613	.	4.680	4.680	2.746	1.004	0.587	0.986	0.965	0.891	651	Class_I_myosin,_motor_domain;Myosin_head,_motor_domain	.	.	.	MYO1F	448	0	589	129	0.17966573816156	TRUE	NA
ENSG00000076662.10	.	BCM	GRCh38.p13	chr19	10333911	10333929	+	GAGGGGCAGATAGGTGCTC	GAGGGGCAGATAGGTGCTC	-	Frame_Shift_Del	DEL	ENST00000160262.10	exon7	c.1572_1590del	p.S525Rfs*44	exonic	ENSG00000076662.10	.	frameshift deletion	ENSG00000076662.10:ENST00000160262.10:exon7:c.1572_1590del:p.S525Rfs*44	19p13.2	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ICAM3	277	0	375	27	0.0671641791044776	TRUE	TRUE
ENSG00000198597.9	.	BCM	GRCh38.p13	chr19	30445532	30445532	+	G	G	A	Missense_Mutation	SNP	ENST00000355537.4	exon2	c.G1970A	p.R657H	exonic	ENSG00000198597.9	.	nonsynonymous SNV	ENSG00000198597.9:ENST00000355537.4:exon2:c.G1970A:p.R657H	19q12	C3N-03839	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	L	T	D	0.667	T	T	T	0.373	0.418	0.527	1.866	T	T	T	T	D	D	4.112	27.900	0.999	D	D	0.654	6.517	0.687	7.510	1.000	0.487	0.574	0.578	0.613	.	5.420	5.420	7.709	1.175	0.676	1.000	0.998	0.890	771	Zinc_finger_C2H2-type	.	.	ID=COSV62824617;OCCURENCE=1(breast),2(large_intestine)	ZNF536	197	1	260	54	0.171974522292994	TRUE	TRUE
ENSG00000086548.9	.	BCM	GRCh38.p13	chr19	41762209	41762209	+	T	T	C	Missense_Mutation	SNP	ENST00000199764.7	exon4	c.T944C	p.M315T	exonic	ENSG00000086548.9	.	nonsynonymous SNV	ENSG00000086548.9:ENST00000199764.7:exon4:c.T944C:p.M315T	19q13.2	C3N-03839	.	.	.	.	.	.	.	.	.	0.14	T	T	.	.	.	N	.	T	N	0.020	T	T	T	0.015	0.417	0.040	0.180	T	.	T	T	T	.	-1.201	0.002	0.166	N	N	-1.635	0.048	-1.657	0.060	0.000	0.497	0.590	0.547	0.542	.	2.150	-4.300	-1.357	-0.291	-1.257	0.000	0.015	0.006	573	.	.	.	.	CEACAM6	163	0	207	61	0.227611940298507	NA	TRUE
ENSG00000156261.13	.	BCM	GRCh38.p13	chr21	29062143	29062143	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000286788.9	exon11	c.1196dupT	p.K400Qfs*7	exonic	ENSG00000156261.13	.	frameshift insertion	ENSG00000156261.13:ENST00000286788.9:exon11:c.1196dupT:p.K400Qfs*7	21q21.3	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCT8	NA	NA	NA	NA	NA	NA	NA
ENSG00000100346.18	.	BCM	GRCh38.p13	chr22	39646774	39646774	+	G	G	A	Missense_Mutation	SNP	ENST00000402142.4	exon8	c.G1355A	p.R452H	exonic	ENSG00000100346.18	.	nonsynonymous SNV	ENSG00000100346.18:ENST00000402142.4:exon8:c.G1355A:p.R452H	22q13.1	C3N-03839	0.0001	0	0	0	0.0028	7.019e-05	0	0	rs575049762	16.20	D	D	D	D	D	D	L	D	D	0.582	D	D	D	0.654	.	0.905	1.134	T	T	D	D	T	D	3.896	26.300	0.999	D	D	0.393	4.302	0.294	3.681	1.000	0.516	0.610	0.578	0.613	.	3.550	3.550	4.738	1.176	0.618	1.000	0.907	0.936	872	.	.	.	.	CACNA1I	366	0	537	101	0.158307210031348	TRUE	NA
ENSG00000146950.13	.	BCM	GRCh38.p13	chrX	9937379	9937379	+	C	C	T	Missense_Mutation	SNP	ENST00000380913.8	exon7	c.C3833T	p.P1278L	exonic	ENSG00000146950.13	.	nonsynonymous SNV	ENSG00000146950.13:ENST00000380913.8:exon7:c.C3833T:p.P1278L	Xp22.2	C3N-03839	5.095e-05	0	0	0	0	9.419e-05	0	0	rs748501801	2.19	T	T	B	B	N	N	L	T	D	0.040	T	T	D	0.032	0.255	0.527	0.320	T	T	T	T	T	T	0.565	7.169	0.712	N	.	.	.	.	.	0.998	.	.	.	.	.	3.180	0.173	-0.017	0.788	0.454	0.001	0.002	0.003	949	.	.	.	.	SHROOM2	157	1	217	57	0.208029197080292	TRUE	NA
ENSG00000008086.13	.	BCM	GRCh38.p13	chrX	18619930	18619930	+	C	C	G	Missense_Mutation	SNP	ENST00000623535.2	exon16	c.C2340G	p.F780L	exonic	ENSG00000008086.13	.	nonsynonymous SNV	ENSG00000008086.13:ENST00000623535.2:exon16:c.C2340G:p.F780L	Xp22.13	C3N-03839	.	.	.	.	.	.	.	.	.	9.19	D	D	P	B	D	D	M	T	N	0.430	T	T	D	0.428	0.246	0.816	0.399	T	T	T	T	D	D	2.786	23.000	0.999	D	.	.	.	.	.	0.998	.	.	.	.	.	5.440	4.560	2.079	1.025	0.599	1.000	1.000	0.998	137	.	.	.	.	CDKL5	225	0	300	125	0.294117647058824	TRUE	TRUE
ENSG00000124313.16	.	BCM	GRCh38.p13	chrX	53250984	53250984	+	C	C	T	Missense_Mutation	SNP	ENST00000642864.1	exon5	c.G1592A	p.R531Q	exonic	ENSG00000124313.16	.	nonsynonymous SNV	ENSG00000124313.16:ENST00000642864.1:exon5:c.G1592A:p.R531Q	Xp11.22	C3N-03839	.	.	.	.	.	.	.	.	.	6.17	D	T	P	B	N	D	.	T	N	0.429	T	T	D	0.202	0.065	0.463	1.520	T	.	T	T	D	D	3.711	25.500	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.280	4.360	5.847	0.947	0.597	1.000	1.000	1.000	49	.	.	.	.	IQSEC2	198	0	394	33	0.0772833723653396	TRUE	NA
ENSG00000101890.5	.	BCM	GRCh38.p13	chrX	109388621	109388621	+	G	G	A	Missense_Mutation	SNP	ENST00000218006.3	exon15	c.C2824T	p.P942S	exonic	ENSG00000101890.5	.	nonsynonymous SNV	ENSG00000101890.5:ENST00000218006.3:exon15:c.C2824T:p.P942S	Xq22.3	C3N-03839	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	M	D	D	0.839	D	D	D	0.848	0.875	0.868	0.525	T	D	D	D	D	D	3.474	24.600	0.999	D	.	.	.	.	.	0.970	.	.	.	.	.	4.210	3.310	7.955	1.176	0.674	1.000	0.859	0.996	491	Adenylyl_cyclase_class-3/4/guanylyl_cyclase	.	.	.	GUCY2F	253	0	348	202	0.367272727272727	TRUE	TRUE
ENSG00000123496.8	.	BCM	GRCh38.p13	chrX	115010676	115010676	+	G	G	A	Missense_Mutation	SNP	ENST00000243213.2	exon6	c.C674T	p.S225F	exonic	ENSG00000123496.8	.	nonsynonymous SNV	ENSG00000123496.8:ENST00000243213.2:exon6:c.C674T:p.S225F	Xq23	C3N-03839	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	N	N	L	D	D	0.364	T	D	D	0.426	0.677	0.558	0.880	T	D	T	T	D	T	4.209	28.700	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.150	5.150	6.017	1.176	0.618	1.000	0.998	0.979	924	Fibronectin_type_III;Type_I_cytokine_receptor,_cytokine-binding_domain	.	.	.	IL13RA2	58	0	59	37	0.385416666666667	TRUE	TRUE
ENSG00000186376.15	.	BCM	GRCh38.p13	chrX	135291094	135291094	+	C	C	A	Missense_Mutation	SNP	ENST00000370766.8	exon6	c.G738T	p.E246D	exonic	ENSG00000186376.15	.	nonsynonymous SNV	ENSG00000186376.15:ENST00000370766.8:exon6:c.G738T:p.E246D	Xq26.3	C3N-03839	.	.	.	.	.	.	.	.	.	3.19	D	D	B	B	N	N	M	T	N	0.319	T	T	T	0.067	0.662	0.694	0.174	T	T	T	T	T	T	0.937	10.840	0.986	N	.	.	.	.	.	0.097	.	.	.	.	.	2.780	-1.330	-1.182	-0.076	-0.285	0.000	0.996	0.986	377	Krueppel-associated_box	.	.	.	ZNF75D	181	0	375	33	0.0808823529411765	TRUE	TRUE
ENSG00000155966.14	.	BCM	GRCh38.p13	chrX	148956468	148956468	+	A	A	T	Missense_Mutation	SNP	ENST00000370460.7	exon11	c.A2423T	p.D808V	exonic	ENSG00000155966.14	.	nonsynonymous SNV	ENSG00000155966.14:ENST00000370460.7:exon11:c.A2423T:p.D808V	Xq28	C3N-03839	.	.	.	.	.	.	.	.	.	12.19	D	D	B	B	D	D	M	T	D	0.539	T	T	D	0.329	0.678	0.749	0.626	T	D	D	T	D	D	2.659	22.800	0.989	D	.	.	.	.	.	0.990	.	.	.	.	.	5.870	2.280	2.312	0.314	0.756	1.000	0.995	0.998	877	.	.	.	.	AFF2	303	0	369	166	0.310280373831776	TRUE	TRUE
ENSG00000102195.10	.	BCM	GRCh38.p13	chrX	151180193	151180193	+	G	G	A	Missense_Mutation	SNP	ENST00000218316.4	exon2	c.G610A	p.V204M	exonic	ENSG00000102195.10	.	nonsynonymous SNV	ENSG00000102195.10:ENST00000218316.4:exon2:c.G610A:p.V204M	Xq28	C3N-03839	.	.	.	.	.	.	.	.	.	7.19	T	D	P	P	D	D	L	T	D	0.753	T	T	T	0.271	0.554	0.522	0.389	T	T	T	T	D	D	3.691	25.400	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	4.330	4.330	9.943	1.172	0.672	1.000	0.652	0.144	924	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV54436783;OCCURENCE=1(large_intestine),1(stomach),1(kidney),1(pancreas),1(skin)	GPR50	182	0	227	114	0.334310850439883	TRUE	TRUE
ENSG00000198910.14	.	BCM	GRCh38.p13	chrX	153864848	153864848	+	G	G	A	Missense_Mutation	SNP	ENST00000370060.7	exon23	c.C3019T	p.R1007W	exonic	ENSG00000198910.14	.	nonsynonymous SNV	ENSG00000198910.14:ENST00000370060.7:exon23:c.C3019T:p.R1007W	Xq28	C3N-03839	.	.	.	.	.	.	.	.	.	9.19	D	D	D	P	N	N	M	T	D	0.372	T	T	D	0.271	0.560	0.620	0.956	T	D	T	T	D	D	3.412	24.400	0.999	N	.	.	.	.	.	0.935	.	.	.	.	.	5.170	4.240	0.747	1.176	0.671	0.000	0.977	0.872	155	Fibronectin_type_III	.	.	ID=COSV62827938;OCCURENCE=1(large_intestine),1(NS),1(stomach)	L1CAM	461	0	827	120	0.126715945089757	TRUE	TRUE
ENSG00000130827.6	.	BCM	GRCh38.p13	chrX	154466035	154466035	+	G	G	T	Missense_Mutation	SNP	ENST00000369682.4	exon14	c.G2633T	p.G878V	exonic	ENSG00000130827.6	.	nonsynonymous SNV	ENSG00000130827.6:ENST00000369682.4:exon14:c.G2633T:p.G878V	Xq28	C3N-03839	.	.	.	.	.	.	.	.	.	12.14	D	D	.	.	D	D	.	T	D	0.768	D	D	D	0.770	0.781	0.974	.	T	.	D	D	D	.	3.646	25.200	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.320	5.320	4.680	1.176	0.674	1.000	0.979	0.957	74	.	.	.	.	PLXNA3	223	0	420	58	0.121338912133891	TRUE	TRUE
ENSG00000052795.13	.	BCM	GRCh38.p13	chr4	158895749	158895749	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000052795.13	ENST00000264433.11:exon16:c.3151-1G>A	.	.	4q32.1	C3N-03839	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.395	34	0.995	D	.	1.231	26.911	1.087	25.609	1.000	0.094	0.085	0.084	0.130	0.979	5.450	5.450	9.940	1.176	0.618	1.000	0.999	0.979	845	.	.	.	.	FNIP2	118	0	164	36	0.18	TRUE	TRUE
ENSG00000078808.18	.	BCM	GRCh38.p13	chr1	1217524	1217524	+	G	G	A	Silent	SNP	ENST00000360001.11	exon7	c.C1056T	p.H352H	exonic	ENSG00000078808.18	.	synonymous SNV	ENSG00000078808.18:ENST00000360001.11:exon7:c.C1056T:p.H352H	1p36.33	C3N-03839	0.0007	0.0001	0.0001	0.0002	0.0018	0.0010	0	0	rs141093711	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SDF4	85	0	153	25	0.140449438202247	TRUE	NA
ENSG00000158828.8	.	BCM	GRCh38.p13	chr1	20639954	20639954	+	A	A	T	Silent	SNP	ENST00000321556.5	exon3	c.A738T	p.R246R	exonic	ENSG00000158828.8	.	synonymous SNV	ENSG00000158828.8:ENST00000321556.5:exon3:c.A738T:p.R246R	1p36.12	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PINK1	567	0	815	157	0.161522633744856	TRUE	TRUE
ENSG00000160785.13	.	BCM	GRCh38.p13	chr1	156207977	156207977	+	C	C	T	Silent	SNP	ENST00000359511.4	exon3	c.C717T	p.L239L	exonic	ENSG00000160785.13	.	synonymous SNV	ENSG00000160785.13:ENST00000359511.4:exon3:c.C717T:p.L239L	1q22	C3N-03839	3.295e-05	0	0	0	0	5.996e-05	0	0	rs764738266	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100849321;OCCURENCE=1(central_nervous_system)	SLC25A44	212	0	336	61	0.153652392947103	TRUE	NA
ENSG00000133067.17	.	BCM	GRCh38.p13	chr1	202276387	202276387	+	C	C	T	Silent	SNP	ENST00000367278.7	exon5	c.C510T	p.D170D	exonic	ENSG00000133067.17	.	synonymous SNV	ENSG00000133067.17:ENST00000367278.7:exon5:c.C510T:p.D170D	1q32.1	C3N-03839	2.478e-05	0.0002	0	0	0	1.503e-05	0	0	rs373499034	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55167093;OCCURENCE=1(cervix),2(large_intestine),1(lung),1(endometrium)	LGR6	266	0	336	43	0.113456464379947	TRUE	TRUE
ENSG00000115998.7	.	BCM	GRCh38.p13	chr2	70150446	70150446	+	C	C	T	Silent	SNP	ENST00000264434.6	exon10	c.G1635A	p.R545R	exonic	ENSG00000115998.7	.	synonymous SNV	ENSG00000115998.7:ENST00000264434.6:exon10:c.G1635A:p.R545R	2p13.3	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C2orf42	615	0	865	169	0.163442940038685	TRUE	TRUE
ENSG00000204406.13	.	BCM	GRCh38.p13	chr2	148489391	148489391	+	A	A	G	Silent	SNP	ENST00000407073.5	exon12	c.A3060G	p.R1020R	exonic	ENSG00000204406.13	.	synonymous SNV	ENSG00000204406.13:ENST00000407073.5:exon12:c.A3060G:p.R1020R	2q23.1	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MBD5	314	1	455	68	0.130019120458891	TRUE	TRUE
ENSG00000154928.18	.	BCM	GRCh38.p13	chr3	135166023	135166023	+	G	G	A	Silent	SNP	ENST00000398015.8	exon8	c.G1641A	p.A547A	exonic	ENSG00000154928.18	.	synonymous SNV	ENSG00000154928.18:ENST00000398015.8:exon8:c.G1641A:p.A547A	3q22.2	C3N-03839	2.485e-05	0.0001	0	0	0	2.998e-05	0	0	rs776531462	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101212909;OCCURENCE=1(ovary),1(stomach)	EPHB1	273	0	419	59	0.123430962343096	TRUE	NA
ENSG00000197894.11	.	BCM	GRCh38.p13	chr4	99072602	99072602	+	T	T	C	Silent	SNP	ENST00000296412.13	exon8	c.A1071G	p.K357K	exonic	ENSG00000197894.11	.	synonymous SNV	ENSG00000197894.11:ENST00000296412.13:exon8:c.A1071G:p.K357K	4q23	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADH5	101	0	141	26	0.155688622754491	TRUE	TRUE
ENSG00000005073.6	.	BCM	GRCh38.p13	chr7	27184842	27184842	+	G	G	A	Silent	SNP	ENST00000006015.4	exon1	c.C303T	p.G101G	exonic	ENSG00000005073.6	.	synonymous SNV	ENSG00000005073.6:ENST00000006015.4:exon1:c.C303T:p.G101G	7p15.2	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50053023;OCCURENCE=1(large_intestine),2(urinary_tract)	HOXA11	262	0	374	62	0.142201834862385	TRUE	TRUE
ENSG00000173253.15	.	BCM	GRCh38.p13	chr9	1056646	1056646	+	C	C	T	Silent	SNP	ENST00000382251.7	exon5	c.C1059T	p.T353T	exonic	ENSG00000173253.15	.	synonymous SNV	ENSG00000173253.15:ENST00000382251.7:exon5:c.C1059T:p.T353T	9p24.3	C3N-03839	.	.	.	.	.	.	.	.	rs564464685	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DMRT2	277	0	315	59	0.157754010695187	TRUE	NA
ENSG00000148602.6	.	BCM	GRCh38.p13	chr10	84232410	84232410	+	G	G	A	Silent	SNP	ENST00000372105.4	exon4	c.C1389T	p.Y463Y	exonic	ENSG00000148602.6	.	synonymous SNV	ENSG00000148602.6:ENST00000372105.4:exon4:c.C1389T:p.Y463Y	10q23.1	C3N-03839	0.0008	0.0077	0.0005	0	0.0008	7.534e-05	0	0.0003	rs142074653	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64513694;OCCURENCE=1(central_nervous_system),1(endometrium)	LRIT1	480	0	604	143	0.191432396251673	TRUE	TRUE
ENSG00000197430.11	.	BCM	GRCh38.p13	chr10	96349761	96349761	+	C	C	T	Silent	SNP	ENST00000371172.8	exon4	c.G138A	p.V46V	exonic	ENSG00000197430.11	.	synonymous SNV	ENSG00000197430.11:ENST00000371172.8:exon4:c.G138A:p.V46V	10q24.1	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OPALIN	238	0	341	50	0.127877237851662	TRUE	NA
ENSG00000165917.10	.	BCM	GRCh38.p13	chr11	47447860	47447860	+	G	G	A	Silent	SNP	ENST00000298854.7	exon2	c.C483T	p.L161L	exonic	ENSG00000165917.10	.	synonymous SNV	ENSG00000165917.10:ENST00000298854.7:exon2:c.C483T:p.L161L	11p11.2	C3N-03839	2.785e-05	0	9.699e-05	0	0	0	0	0.0001	rs754775068	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAPSN	298	0	473	90	0.159857904085258	TRUE	NA
ENSG00000130037.5	.	BCM	GRCh38.p13	chr12	5045008	5045008	+	G	G	A	Silent	SNP	ENST00000252321.5	exon1	c.G861A	p.A287A	exonic	ENSG00000130037.5	.	synonymous SNV	ENSG00000130037.5:ENST00000252321.5:exon1:c.G861A:p.A287A	12p13.32	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52907103;OCCURENCE=1(meninges),1(cervix),1(large_intestine),1(endometrium)	KCNA5	382	0	545	117	0.176737160120846	TRUE	TRUE
ENSG00000167522.16	.	BCM	GRCh38.p13	chr16	89281355	89281355	+	G	G	A	Silent	SNP	ENST00000301030.10	exon9	c.C5187T	p.A1729A	exonic	ENSG00000167522.16	.	synonymous SNV	ENSG00000167522.16:ENST00000301030.10:exon9:c.C5187T:p.A1729A	16q24.3	C3N-03839	8.384e-06	0	0	0	0	0	0	6.19e-05	rs770331336	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56354446;OCCURENCE=2(large_intestine)	ANKRD11	102	0	128	31	0.19496855345912	TRUE	TRUE
ENSG00000159882.13	.	BCM	GRCh38.p13	chr19	44010522	44010522	+	C	C	T	Silent	SNP	ENST00000429154.7	exon5	c.C483T	p.F161F	exonic	ENSG00000159882.13	.	synonymous SNV	ENSG00000159882.13:ENST00000429154.7:exon5:c.C483T:p.F161F	19q13.31	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF230	322	0	383	160	0.294659300184162	TRUE	TRUE
ENSG00000142408.5	.	BCM	GRCh38.p13	chr19	53963349	53963349	+	G	G	C	Silent	SNP	ENST00000270458.2	exon1	c.G207C	p.G69G	exonic	ENSG00000142408.5	.	synonymous SNV	ENSG00000142408.5:ENST00000270458.2:exon1:c.G207C:p.G69G	19q13.42	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNG8	180	0	231	87	0.273584905660377	TRUE	TRUE
ENSG00000087510.7	.	BCM	GRCh38.p13	chr20	56631810	56631810	+	C	C	T	Silent	SNP	ENST00000201031.3	exon3	c.C540T	p.V180V	exonic	ENSG00000087510.7	.	synonymous SNV	ENSG00000087510.7:ENST00000201031.3:exon3:c.C540T:p.V180V	20q13.31	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TFAP2C	275	0	464	82	0.15018315018315	TRUE	TRUE
ENSG00000178035.12	.	BCM	GRCh38.p13	chr3	49029236	49029236	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000178035.12	.	.	.	3p21.31	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IMPDH2	340	0	422	70	0.142276422764228	TRUE	NA
ENSG00000138835.22	.	BCM	GRCh38.p13	chr9	113594142	113594142	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000138835.22	.	.	.	9q32	C3N-03839	.	.	.	.	.	.	.	.	.	3.14	D	D	.	.	.	D	.	T	N	0.224	T	T	T	0.075	0.208	0.225	.	.	.	T	T	T	T	0.756	8.971	0.999	N	N	-0.701	0.811	-0.633	0.997	1.000	0.394	0.518	0.520	0.373	.	3.910	3.010	0.897	1.172	0.672	0.001	0.060	0.066	852	.	.	.	.	RGS3	267	0	386	74	0.160869565217391	TRUE	NA
ENSG00000221949.5	.	BCM	GRCh38.p13	chr12	62602955	62602955	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000221949.5	.	.	.	12q14.1	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC01465	216	0	321	55	0.146276595744681	TRUE	NA
ENSG00000165525.18	.	BCM	GRCh38.p13	chr14	49796240	49796240	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000165525.18	.	.	.	14q21.3	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEMF	142	0	251	38	0.131487889273356	TRUE	NA
ENSG00000279735.2	.	BCM	GRCh38.p13	chr15	25092337	25092337	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000279735.2	.	.	.	15q11.2	C3N-03839	.	.	.	.	.	.	.	.	rs1055578757	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC124312.4	177	0	218	49	0.183520599250936	TRUE	NA
ENSG00000267749.1	.	BCM	GRCh38.p13	chr19	2643128	2643128	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000267749.1	.	.	.	19p13.3	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC092068.3	724	0	968	97	0.0910798122065728	TRUE	NA
ENSG00000221930.6	.	BCM	GRCh38.p13	chrX	130495639	130495639	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000221930.6	.	.	.	Xq26.1	C3N-03839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DENND10P1	613	1	801	397	0.331385642737897	TRUE	NA
ENSG00000116641.18	.	BCM	GRCh38.p13	chr1	62633575	62633575	+	C	C	A	Nonsense_Mutation	SNP	ENST00000635253.2	exon10	c.G1039T	p.E347X	exonic	ENSG00000116641.18	.	stopgain	ENSG00000116641.18:ENST00000635253.2:exon10:c.G1039T:p.E347X	1p31.3	C3L-04479	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.946	.	.	.	.	.	.	.	.	.	D	D	.	.	7.065	37	0.996	D	N	1.042	15.297	0.846	11.642	1.000	0.707	0.709	0.609	0.714	.	4.010	4.010	7.812	1.022	0.596	1.000	0.993	0.919	835	.	.	.	.	DOCK7	100	0	225	22	0.0890688259109312	TRUE	TRUE
ENSG00000175143.4	.	BCM	GRCh38.p13	chr1	248406715	248406715	+	G	G	A	Missense_Mutation	SNP	ENST00000366474.1	exon1	c.G721A	p.D241N	exonic	ENSG00000175143.4	.	nonsynonymous SNV	ENSG00000175143.4:ENST00000366474.1:exon1:c.G721A:p.D241N	1q44	C3L-04479	.	.	.	.	.	.	.	.	.	5.20	D	D	P	P	U	N	L	T	D	0.359	T	T	T	0.110	0.477	0.403	0.023	T	T	T	T	D	D	2.411	22.100	0.998	N	N	-0.082	2.231	-0.182	1.828	0.951	0.487	0.233	0.574	0.564	.	4.750	3.840	0.646	0.945	0.656	0.001	0.100	0.140	982	GPCR,_rhodopsin-like,_7TM	.	.	.	OR2T1	158	0	302	26	0.0792682926829268	TRUE	TRUE
ENSG00000151690.15	.	BCM	GRCh38.p13	chr2	190436967	190436967	+	C	C	T	Missense_Mutation	SNP	ENST00000392328.6	exon3	c.C938T	p.T313I	exonic	ENSG00000151690.15	.	nonsynonymous SNV	ENSG00000151690.15:ENST00000392328.6:exon3:c.C938T:p.T313I	2q32.2	C3L-04479	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	N	0.882	D	D	D	0.622	0.634	0.731	1.251	D	T	D	D	D	D	3.353	24.300	0.998	D	D	0.669	6.706	0.586	6.058	1.000	0.707	0.725	0.602	0.655	.	6.070	6.070	7.905	1.026	0.599	1.000	0.227	0.893	697	Major_facilitator_superfamily_associated_domain	.	.	.	MFSD6	280	0	445	45	0.0918367346938776	TRUE	TRUE
ENSG00000206557.6	.	BCM	GRCh38.p13	chr3	32890543	32890543	+	G	G	A	Missense_Mutation	SNP	ENST00000383763.6	exon4	c.G1339A	p.V447M	exonic	ENSG00000206557.6	.	nonsynonymous SNV	ENSG00000206557.6:ENST00000383763.6:exon4:c.G1339A:p.V447M	3p22.3	C3L-04479	0.0004	0	0	0.0043	0	7.518e-05	0	0.0001	rs192447957	5.20	T	T	B	B	N	D	N	D	N	0.096	T	T	D	0.136	.	0.323	0.969	T	T	T	T	T	D	2.132	20.300	0.980	D	N	-0.248	1.747	-0.097	2.057	1.000	0.646	0.588	0.696	0.542	.	5.650	2.750	3.309	0.245	0.676	1.000	0.980	0.997	845	.	.	.	ID=COSV101070400;OCCURENCE=2(stomach)	TRIM71	221	1	448	78	0.14828897338403	TRUE	NA
ENSG00000163848.19	.	BCM	GRCh38.p13	chr3	125234297	125234300	+	TACC	TACC	-	Nonsense_Mutation	DEL	ENST00000360647.8	exon8	c.697_700del	p.G233*	exonic	ENSG00000163848.19	.	stopgain	ENSG00000163848.19:ENST00000360647.8:exon8:c.697_700del:p.G233*	3q21.2	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF148	145	0	212	16	0.0701754385964912	TRUE	TRUE
ENSG00000262576.3	.	BCM	GRCh38.p13	chr5	141357089	141357089	+	G	G	A	Missense_Mutation	SNP	ENST00000571252.3	exon1	c.G1982A	p.R661Q	exonic	ENSG00000262576.3	.	nonsynonymous SNV	ENSG00000262576.3:ENST00000571252.3:exon1:c.G1982A:p.R661Q	5q31.3	C3L-04479	.	.	.	.	.	.	.	.	.	6.8	.	D	.	.	.	D	.	.	.	0.448	.	.	D	.	.	0.687	0.959	.	.	T	T	.	D	3.765	25.700	0.999	D	D	.	.	.	.	1.000	0.549	0.547	0.604	0.616	.	5.590	4.700	5.699	1.175	0.676	0.995	0.144	0.001	642	Cadherin-like	.	.	ID=COSV53893624;OCCURENCE=2(large_intestine)	PCDHGA4	289	0	486	44	0.0830188679245283	TRUE	TRUE
ENSG00000091704.10	.	BCM	GRCh38.p13	chr7	130383686	130383686	+	-	NA	ACT	In_Frame_Ins	INS	ENST00000011292.8	exon6	c.588_589insACT	p.T197_Q198insT	exonic	ENSG00000091704.10	.	nonframeshift insertion	ENSG00000091704.10:ENST00000011292.8:exon6:c.588_589insACT:p.T197_Q198insT	7q32.2	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPA1	NA	NA	NA	NA	NA	NA	NA
ENSG00000168619.16	.	BCM	GRCh38.p13	chr8	39729908	39729908	+	G	G	A	Missense_Mutation	SNP	ENST00000265707.10	exon20	c.G2188A	p.V730I	exonic	ENSG00000168619.16	.	nonsynonymous SNV	ENSG00000168619.16:ENST00000265707.10:exon20:c.G2188A:p.V730I	8p11.22	C3L-04479	0.0002	9.615e-05	8.639e-05	0	0	0.0003	0	0	rs142507282	1.18	T	T	B	B	.	N	N	D	N	0.144	T	T	T	0.255	.	0.252	0.016	T	T	T	T	T	.	-0.920	0.012	0.385	N	N	-1.983	0.010	-1.975	0.015	0.000	0.487	0.574	0.547	0.564	.	3.630	-1.920	-0.033	-0.938	-2.602	0.000	0.002	0.000	856	.	.	.	ID=COSV55843179;OCCURENCE=2(large_intestine),6(ovary),1(endometrium)	ADAM18	136	0	259	21	0.075	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21974776	21974776	+	-	NA	GGCCAGCC	Frame_Shift_Ins	INS	ENST00000304494.9	exon1	c.51_52insGGCTGGCC	p.T18Gfs*11	exonic	ENSG00000147889.17	.	frameshift insertion	ENSG00000147889.17:ENST00000304494.9:exon1:c.51_52insGGCTGGCC:p.T18Gfs*11	9p21.3	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	NA	NA	NA	NA	NA	NA	NA
ENSG00000023191.17	.	BCM	GRCh38.p13	chr11	498092	498092	+	C	C	A	Missense_Mutation	SNP	ENST00000354420.7	exon9	c.G1006T	p.V336L	exonic	ENSG00000023191.17	.	nonsynonymous SNV	ENSG00000023191.17:ENST00000354420.7:exon9:c.G1006T:p.V336L	11p15.5	C3L-04479	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.207	T	T	T	0.072	0.673	0.358	0.140	T	T	T	T	T	T	0.527	6.783	0.823	N	N	-0.858	0.574	-0.944	0.561	0.998	0.672	0.702	0.702	0.711	.	3.830	-0.063	-1.010	-0.063	0.524	0.000	0.011	0.108	884	.	.	.	.	RNH1	197	0	443	36	0.0751565762004175	TRUE	TRUE
ENSG00000166927.13	.	BCM	GRCh38.p13	chr11	60389487	60389487	+	C	C	T	Missense_Mutation	SNP	ENST00000300184.8	exon5	c.C437T	p.S146F	exonic	ENSG00000166927.13	.	nonsynonymous SNV	ENSG00000166927.13:ENST00000300184.8:exon5:c.C437T:p.S146F	11q12.2	C3L-04479	.	.	.	.	.	.	.	.	.	1.20	T	D	P	B	N	N	N	T	N	0.369	T	T	T	0.087	0.719	0.118	0.097	T	T	T	T	T	T	0.960	11.120	0.606	N	N	-1.181	0.241	-1.254	0.241	1.000	0.503	0.623	0.574	0.564	.	3.690	-0.365	0.871	-0.763	-0.780	0.018	0.001	0.010	828	.	.	.	.	MS4A7	278	1	499	44	0.0810313075506446	TRUE	TRUE
ENSG00000168439.17	.	BCM	GRCh38.p13	chr11	64202892	64202892	+	T	T	C	Missense_Mutation	SNP	ENST00000305218.9	exon11	c.T1262C	p.I421T	exonic	ENSG00000168439.17	.	nonsynonymous SNV	ENSG00000168439.17:ENST00000305218.9:exon11:c.T1262C:p.I421T	11q13.1	C3L-04479	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.881	T	T	D	0.715	0.741	0.790	1.555	T	T	D	D	D	D	4.345	29.900	0.998	D	D	0.754	7.938	0.709	7.918	1.000	0.707	0.702	0.725	0.714	.	5.000	5.000	7.002	1.138	0.665	1.000	1.000	0.981	596	Tetratricopeptide_repeat-containing_domain	.	.	.	STIP1	249	0	518	47	0.0831858407079646	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-04479	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	284	0	530	105	0.165354330708661	TRUE	TRUE
ENSG00000072736.19	.	BCM	GRCh38.p13	chr16	68191326	68191326	+	G	G	A	Missense_Mutation	SNP	ENST00000346183.8	exon9	c.G2657A	p.C886Y	exonic	ENSG00000072736.19	.	nonsynonymous SNV	ENSG00000072736.19:ENST00000346183.8:exon9:c.G2657A:p.C886Y	16q22.1	C3L-04479	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	D	D	L	T	N	0.612	T	T	T	0.157	0.258	0.068	0.545	T	T	T	T	D	D	3.870	26.200	0.995	D	D	0.554	5.485	0.588	6.077	1.000	0.707	0.725	0.725	0.714	.	5.490	4.520	6.248	1.176	0.676	1.000	1.000	0.998	12	.	.	.	.	NFATC3	213	0	318	25	0.0728862973760933	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675109	7675109	+	T	T	C	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.A503G	p.H168R	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.A503G:p.H168R	17p13.1	C3L-04479	.	.	.	.	.	.	.	.	rs867114783	18.20	D	D	D	D	N	D	M	D	D	0.516	D	D	D	0.562	0.765	0.970	1.545	T	D	D	D	D	D	2.929	23.300	0.975	D	D	-0.026	2.420	-0.206	1.771	0.746	0.722	0.698	0.698	0.735	.	5.590	0.619	5.173	0.166	0.665	1.000	0.845	0.725	434	p53,_DNA-binding_domain	.	.	ID=COSV52698349;OCCURENCE=1(breast),1(liver),3(oesophagus),6(large_intestine),3(central_nervous_system),2(ovary),3(haematopoietic_and_lymphoid_tissue),3(stomach),1(soft_tissue),1(pancreas),2(lung),1(small_intestine),1(endometrium)	TP53	356	1	548	47	0.0789915966386555	TRUE	TRUE
ENSG00000091536.19	.	BCM	GRCh38.p13	chr17	18119750	18119750	+	C	C	T	Missense_Mutation	SNP	ENST00000647165.2	exon2	c.C950T	p.A317V	exonic	ENSG00000091536.19	.	nonsynonymous SNV	ENSG00000091536.19:ENST00000647165.2:exon2:c.C950T:p.A317V	17p11.2	C3L-04479	0.0001	0.0013	0	0	0	0	0	0.0002	rs372516960	7.19	T	D	D	P	.	N	L	D	N	0.475	D	D	D	0.314	.	0.852	.	T	T	T	T	T	T	2.888	23.200	0.999	D	N	0.377	4.207	0.376	4.194	0.192	0.517	0.547	0.479	0.563	.	5.820	5.820	2.457	0.925	0.575	0.629	0.099	0.009	246	.	.	.	ID=COSV52760857;OCCURENCE=1(large_intestine),1(prostate)	MYO15A	337	0	390	43	0.0993071593533487	TRUE	TRUE
ENSG00000173991.6	.	BCM	GRCh38.p13	chr17	39665754	39665754	+	C	C	A	Missense_Mutation	SNP	ENST00000309889.3	exon2	c.C149A	p.T50N	exonic	ENSG00000173991.6	.	nonsynonymous SNV	ENSG00000173991.6:ENST00000309889.3:exon2:c.C149A:p.T50N	17q12	C3L-04479	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	D	D	0.670	D	D	D	0.556	0.526	0.977	0.920	T	D	T	T	D	T	3.478	24.600	0.904	D	D	0.551	5.457	0.597	6.188	1.000	0.583	0.759	0.460	0.621	.	5.710	5.710	3.278	1.026	0.599	1.000	0.998	0.939	632	.	.	.	.	TCAP	96	0	179	20	0.100502512562814	TRUE	TRUE
ENSG00000185269.12	.	BCM	GRCh38.p13	chr17	81956892	81956892	+	C	C	T	Missense_Mutation	SNP	ENST00000409678.8	exon7	c.G878A	p.R293H	exonic	ENSG00000185269.12	.	nonsynonymous SNV	ENSG00000185269.12:ENST00000409678.8:exon7:c.G878A:p.R293H	17q25.3	C3L-04479	0.0001	0.0001	0	0.0001	0	4.802e-05	0	0.0005	rs780508873	14.19	D	D	D	D	D	D	M	.	D	0.810	D	T	D	0.311	.	0.177	1.525	T	T	T	D	T	D	3.664	25.300	0.999	D	D	0.648	6.448	0.564	5.801	1.000	0.516	0.610	0.576	0.563	.	4.610	4.610	5.601	0.936	0.537	1.000	0.950	0.742	.	.	.	.	ID=COSV68826063;OCCURENCE=1(stomach),1(soft_tissue)	NOTUM	125	0	251	37	0.128472222222222	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51048751	51048751	+	-	NA	A	Frame_Shift_Ins	INS	ENST00000342988.8	exon3	c.316dupA	p.N107Kfs*2	exonic	ENSG00000141646.14	.	frameshift insertion	ENSG00000141646.14:ENST00000342988.8:exon3:c.316dupA:p.N107Kfs*2	18q21.2	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMAD4	NA	NA	NA	NA	NA	NA	NA
ENSG00000065717.15	.	BCM	GRCh38.p13	chr19	3028340	3028340	+	T	T	A	Missense_Mutation	SNP	ENST00000262953.11	exon3	c.A165T	p.E55D	exonic	ENSG00000065717.15	.	nonsynonymous SNV	ENSG00000065717.15:ENST00000262953.11:exon3:c.A165T:p.E55D	19p13.3	C3L-04479	.	.	.	.	.	.	.	.	.	11.20	D	D	B	B	D	D	L	T	D	0.763	T	T	D	0.346	0.643	0.797	0.272	D	T	T	T	D	D	2.019	19.400	0.997	D	D	0.026	2.605	-0.060	2.166	0.916	0.726	0.596	0.641	0.604	.	4.120	-0.813	0.152	0.044	0.481	0.966	0.997	0.975	988	Groucho/TLE,_N-terminal_Q-rich_domain	.	.	.	TLE2	160	0	398	35	0.0808314087759815	TRUE	TRUE
ENSG00000141837.21	.	BCM	GRCh38.p13	chr19	13245222	13245222	+	A	A	G	Missense_Mutation	SNP	ENST00000360228.11	exon31	c.T4910C	p.V1637A	exonic	ENSG00000141837.21	.	nonsynonymous SNV	ENSG00000141837.21:ENST00000360228.11:exon31:c.T4910C:p.V1637A	19p13.13	C3L-04479	.	.	.	.	.	.	.	.	.	18.18	D	D	.	.	D	D	H	D	D	0.788	D	D	D	0.956	0.750	0.978	2.370	D	D	D	D	D	D	4.180	28.500	0.995	D	D	0.907	11.244	0.801	10.149	1.000	0.706	0.547	0.710	0.613	.	4.670	4.670	9.279	1.298	0.740	1.000	0.996	0.996	862	Ion_transport_domain	.	.	.	CACNA1A	138	0	357	32	0.0822622107969152	TRUE	TRUE
ENSG00000083814.13	.	BCM	GRCh38.p13	chr19	57721694	57721694	+	C	C	T	Missense_Mutation	SNP	ENST00000317398.10	exon4	c.G392A	p.C131Y	exonic	ENSG00000083814.13	.	nonsynonymous SNV	ENSG00000083814.13:ENST00000317398.10:exon4:c.G392A:p.C131Y	19q13.43	C3L-04479	8.374e-06	0	0	0	0	0	0	6.563e-05	rs763847941	5.19	D	D	D	P	.	N	L	T	D	0.197	T	T	T	0.030	0.394	0.437	0.262	T	T	T	T	T	T	1.901	18.500	0.405	D	N	-0.185	1.919	-0.399	1.373	0.033	0.563	0.654	0.609	0.492	.	1.660	1.660	0.504	-0.015	0.549	0.119	0.344	0.976	970	.	.	.	.	ZNF671	87	0	162	14	0.0795454545454545	TRUE	NA
ENSG00000196090.12	.	BCM	GRCh38.p13	chr20	42472335	42472335	+	G	G	A	Nonsense_Mutation	SNP	ENST00000373187.5	exon8	c.C1381T	p.R461X	exonic	ENSG00000196090.12	.	stopgain	ENSG00000196090.12:ENST00000373187.5:exon8:c.C1381T:p.R461X	20q12	C3L-04479	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.871	.	.	.	.	.	.	.	.	.	D	D	.	.	7.804	39	0.998	D	N	0.458	4.725	0.259	3.489	0.001	0.554	0.574	0.602	0.564	.	5.280	0.360	0.779	1.083	0.676	0.988	0.953	0.996	939	Fibronectin_type_III	.	.	ID=COSV61958074;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(stomach),1(lung)	PTPRT	305	0	544	54	0.0903010033444816	TRUE	TRUE
ENSG00000184792.16	.	BCM	GRCh38.p13	chr22	30694991	30694991	+	C	C	T	Missense_Mutation	SNP	ENST00000332585.11	exon1	c.C82T	p.P28S	exonic	ENSG00000184792.16	.	nonsynonymous SNV	ENSG00000184792.16:ENST00000332585.11:exon1:c.C82T:p.P28S	22q12.2	C3L-04479	.	.	.	.	.	.	.	.	.	8.20	D	D	D	D	N	D	L	T	N	0.181	T	T	D	0.115	0.270	0.696	1.512	D	T	T	T	D	T	3.402	24.400	0.999	N	N	0.350	4.046	0.312	3.789	1.000	0.443	0.166	0.666	0.604	.	3.640	3.640	0.544	0.928	0.578	0.000	0.998	0.994	356	.	.	.	.	OSBP2	133	0	367	39	0.0960591133004926	TRUE	TRUE
ENSG00000189108.13	.	BCM	GRCh38.p13	chrX	105267451	105267451	+	G	G	C	Missense_Mutation	SNP	ENST00000372582.6	exon5	c.G607C	p.E203Q	exonic	ENSG00000189108.13	.	nonsynonymous SNV	ENSG00000189108.13:ENST00000372582.6:exon5:c.G607C:p.E203Q	Xq22.3	C3L-04479	.	.	.	.	.	.	.	.	.	7.19	T	D	P	P	D	D	L	T	N	0.278	T	T	D	0.347	0.453	0.861	2.064	T	T	T	T	D	D	2.876	23.200	0.996	D	.	.	.	.	.	1.000	.	.	.	.	.	5.550	5.550	6.279	1.176	0.676	1.000	0.978	0.978	135	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	IL1RAPL2	64	0	98	24	0.19672131147541	TRUE	NA
ENSG00000060718.22	.	BCM	GRCh38.p13	chr1	102940336	102940336	+	G	G	A	Silent	SNP	ENST00000370096.9	exon43	c.C3375T	p.D1125D	exonic	ENSG00000060718.22	.	synonymous SNV	ENSG00000060718.22:ENST00000370096.9:exon43:c.C3375T:p.D1125D	1p21.1	C3L-04479	0.1470	0.2038	0.0579	0.0132	0.1731	0.1725	0.1258	0.1315	rs17127270	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62189732;OCCURENCE=1(breast)	COL11A1	340	1	597	57	0.0871559633027523	TRUE	TRUE
ENSG00000169258.7	.	BCM	GRCh38.p13	chr5	176596937	176596937	+	G	G	T	Silent	SNP	ENST00000303991.5	exon2	c.C2898A	p.G966G	exonic	ENSG00000169258.7	.	synonymous SNV	ENSG00000169258.7:ENST00000303991.5:exon2:c.C2898A:p.G966G	5q35.2	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPRIN1	33	0	61	7	0.102941176470588	NA	TRUE
ENSG00000009335.18	.	BCM	GRCh38.p13	chr7	157216908	157216908	+	G	G	A	Silent	SNP	ENST00000348165.10	exon14	c.G1851A	p.T617T	exonic	ENSG00000009335.18	.	synonymous SNV	ENSG00000009335.18:ENST00000348165.10:exon14:c.G1851A:p.T617T	7q36.3	C3L-04479	8.257e-06	0	8.654e-05	0	0	0	0	0	rs777222555	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBE3C	232	0	445	44	0.0899795501022495	TRUE	NA
ENSG00000139323.14	.	BCM	GRCh38.p13	chr12	89525154	89525154	+	G	G	T	Silent	SNP	ENST00000313546.8	exon2	c.C66A	p.T22T	exonic	ENSG00000139323.14;ENSG00000259075.6	.	synonymous SNV	ENSG00000139323.14:ENST00000313546.8:exon2:c.C66A:p.T22T,ENSG00000259075.6:ENST00000548729.5:exon2:c.C66A:p.T22T	12q21.33	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	POC1B	185	1	380	32	0.0776699029126214	TRUE	TRUE
ENSG00000105143.12	.	BCM	GRCh38.p13	chr19	14954209	14954209	+	G	G	A	Silent	SNP	ENST00000221742.7	exon7	c.C1290T	p.Y430Y	exonic	ENSG00000105143.12	.	synonymous SNV	ENSG00000105143.12:ENST00000221742.7:exon7:c.C1290T:p.Y430Y	19p13.12	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC1A6	248	0	466	53	0.102119460500963	TRUE	NA
ENSG00000196090.12	.	BCM	GRCh38.p13	chr20	42350654	42350654	+	G	G	A	Silent	SNP	ENST00000373187.5	exon11	c.C1839T	p.P613P	exonic	ENSG00000196090.12	.	synonymous SNV	ENSG00000196090.12:ENST00000373187.5:exon11:c.C1839T:p.P613P	20q12	C3L-04479	3.313e-05	0	0	0.0002	0	1.499e-05	0	6.056e-05	rs757922932	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61988819;OCCURENCE=1(large_intestine)	PTPRT	123	0	299	45	0.130813953488372	TRUE	TRUE
ENSG00000186716.21	.	BCM	GRCh38.p13	chr22	23181320	23181320	+	G	G	A	Silent	SNP	ENST00000305877.13	exon1	c.G360A	p.E120E	exonic	ENSG00000186716.21	.	synonymous SNV	ENSG00000186716.21:ENST00000305877.13:exon1:c.G360A:p.E120E	22q11.23	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BCR	115	0	221	30	0.119521912350598	TRUE	TRUE
ENSG00000147234.10	.	BCM	GRCh38.p13	chrX	107600313	107600313	+	G	G	T	Silent	SNP	ENST00000276185.8	exon16	c.G2373T	p.V791V	exonic	ENSG00000147234.10	.	synonymous SNV	ENSG00000147234.10:ENST00000276185.8:exon16:c.G2373T:p.V791V	Xq22.3	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FRMPD3	50	0	92	23	0.2	TRUE	TRUE
ENSG00000156920.11	.	BCM	GRCh38.p13	chrX	136351532	136351532	+	G	G	A	Silent	SNP	ENST00000394143.6	exon7	c.G6813A	p.T2271T	exonic	ENSG00000156920.11	.	synonymous SNV	ENSG00000156920.11:ENST00000394143.6:exon7:c.G6813A:p.T2271T	Xq26.3	C3L-04479	1.209e-05	0	0	0	0	2.187e-05	0	0	rs375322857	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54948883;OCCURENCE=1(large_intestine),1(skin)	ADGRG4	42	0	77	13	0.144444444444444	TRUE	TRUE
ENSG00000154122.14	.	BCM	GRCh38.p13	chr5	14871077	14871077	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000154122.14	.	.	.	5p15.2	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANKH	88	0	113	11	0.0887096774193548	TRUE	NA
ENSG00000216802.1	.	BCM	GRCh38.p13	chr6	138692128	138692128	+	T	T	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000216802.1;ENSG00000225177.6	dist=41155;dist=2821	.	.	6q24.1	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL590617.1	334	0	579	56	0.0881889763779528	TRUE	NA
ENSG00000095637.22	.	BCM	GRCh38.p13	chr10	95357029	95357029	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000095637.22	.	.	.	10q24.1	C3L-04479	0.0001	0.0010	0	0	0.0006	0	0	0	rs538233401	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53355522;OCCURENCE=4(prostate)	SORBS1	206	0	331	32	0.0881542699724518	TRUE	NA
ENSG00000199015.4	.	BCM	GRCh38.p13	chr14	101062055	101062055	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000199015.4	.	.	.	14q32.31	C3L-04479	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR377	156	0	379	21	0.0525	TRUE	NA
ENSG00000183018.9	.	BCM	GRCh38.p13	chr17	4536883	4536883	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000183018.9	.	.	.	17p13.2	C3L-04479	7.139e-05	0.0001	0	0.0001	0	4.841e-05	0	0.0002	rs200081709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPNS2	193	0	422	47	0.100213219616205	TRUE	NA
ENSG00000102575.13	.	BCM	GRCh38.p13	chr19	11577002	11577002	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000102575.13	.	.	.	19p13.2	C3L-04479	0.0123	0.1395	0.0050	0.0001	0	6.094e-05	0.0011	0.0001	rs73496603	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACP5	198	0	322	24	0.069364161849711	TRUE	NA
ENSG00000162493.16	.	BCM	GRCh38.p13	chr1	13614390	13614390	+	G	G	A	Missense_Mutation	SNP	ENST00000621990.4	exon5	c.G461A	p.R154Q	exonic	ENSG00000162493.16	.	nonsynonymous SNV	ENSG00000162493.16:ENST00000621990.4:exon5:c.G461A:p.R154Q	1p36.21	C3L-00625	2.475e-05	0	0	0	0	4.5e-05	0	0	rs147446446	10.20	D	D	D	D	N	N	L	T	D	0.673	T	T	D	0.295	.	0.816	0.483	T	T	T	D	D	D	3.960	26.700	0.999	D	N	0.373	4.181	0.292	3.673	0.002	0.707	0.574	0.725	0.564	.	5.930	4.020	3.582	0.244	0.676	1.000	0.041	0.963	982	.	.	.	ID=COSV53848850;OCCURENCE=2(skin),1(lung)	PDPN	96	0	191	18	0.0861244019138756	TRUE	TRUE
ENSG00000115423.19	.	BCM	GRCh38.p13	chr2	84681477	84681477	+	G	G	A	Missense_Mutation	SNP	ENST00000389394.8	exon42	c.G6865A	p.A2289T	exonic	ENSG00000115423.19	.	nonsynonymous SNV	ENSG00000115423.19:ENST00000389394.8:exon42:c.G6865A:p.A2289T	2p11.2	C3L-00625	0.0001	0.0014	0	0	0	0	0	0	rs528704325	2.18	T	.	P	B	.	D	L	T	N	0.316	T	T	T	0.165	.	0.523	0.284	T	T	T	T	T	T	2.584	22.600	0.998	D	N	0.275	3.651	0.360	4.085	0.990	0.487	0.590	0.547	0.564	.	4.890	4.890	6.178	0.227	0.665	1.000	0.942	0.986	594	.	.	.	ID=COSV52859804;OCCURENCE=2(large_intestine)	DNAH6	105	0	174	40	0.186915887850467	TRUE	TRUE
ENSG00000144028.15	.	BCM	GRCh38.p13	chr2	96277829	96277829	+	T	T	A	Missense_Mutation	SNP	ENST00000323853.10	exon40	c.A5732T	p.D1911V	exonic	ENSG00000144028.15	.	nonsynonymous SNV	ENSG00000144028.15:ENST00000323853.10:exon40:c.A5732T:p.D1911V	2q11.2	C3L-00625	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.987	D	D	D	0.889	0.742	0.932	2.499	D	D	D	D	D	D	4.308	29.600	0.995	D	D	0.952	12.466	0.826	10.947	1.000	0.707	0.702	0.702	0.714	.	5.020	5.020	7.522	1.138	0.665	1.000	0.997	0.993	291	Sec63_domain	.	.	.	SNRNP200	317	0	667	142	0.175525339925834	TRUE	TRUE
ENSG00000163519.14	.	BCM	GRCh38.p13	chr3	108853665	108853665	+	G	G	A	Missense_Mutation	SNP	ENST00000295756.11	exon6	c.G349A	p.V117I	exonic	ENSG00000163519.14	.	nonsynonymous SNV	ENSG00000163519.14:ENST00000295756.11:exon6:c.G349A:p.V117I	3q13.13	C3L-00625	2.476e-05	9.656e-05	0	0	0.0003	0	0	0	rs149418284	0.20	T	T	B	B	N	N	L	T	N	0.077	T	T	T	0.049	.	0.157	0.032	T	T	T	T	T	T	-1.801	0.001	0.617	N	N	-2.015	0.008	-2.125	0.007	1.000	0.554	0.588	0.547	0.564	.	5.630	-11.300	-1.931	-0.662	-0.706	0.000	0.183	0.357	672	.	.	.	ID=COSV55469274;OCCURENCE=1(prostate)	TRAT1	131	0	227	49	0.177536231884058	TRUE	TRUE
ENSG00000158220.14	.	BCM	GRCh38.p13	chr3	138472447	138472447	+	G	G	A	Missense_Mutation	SNP	ENST00000389567.9	exon18	c.G1825A	p.V609M	exonic	ENSG00000158220.14	.	nonsynonymous SNV	ENSG00000158220.14:ENST00000389567.9:exon18:c.G1825A:p.V609M	3q22.3	C3L-00625	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.141	T	T	T	0.070	0.260	0.399	0.180	T	T	T	T	T	T	2.104	20.100	0.988	N	N	-0.126	2.095	0.005	2.378	1.000	0.615	0.610	0.659	0.527	.	4.600	3.680	1.472	1.176	0.676	1.000	0.998	0.906	355	.	.	.	.	ESYT3	383	0	765	136	0.150943396226415	TRUE	TRUE
ENSG00000113946.3	.	BCM	GRCh38.p13	chr3	190388234	190388234	+	C	C	G	Missense_Mutation	SNP	ENST00000264734.2	exon1	c.C115G	p.Q39E	exonic	ENSG00000113946.3	.	nonsynonymous SNV	ENSG00000113946.3:ENST00000264734.2:exon1:c.C115G:p.Q39E	3q28	C3L-00625	.	.	.	.	.	.	.	.	.	5.20	D	D	P	B	N	N	N	D	N	0.361	T	D	D	0.161	0.152	0.784	0.118	T	T	T	T	T	T	0.219	3.338	0.803	N	N	-0.954	0.455	-0.978	0.517	0.918	0.554	0.588	0.547	0.613	.	5.910	0.381	-0.026	0.130	-0.257	0.000	0.007	0.011	755	.	.	.	.	CLDN16	235	0	560	91	0.139784946236559	TRUE	TRUE
ENSG00000145536.15	.	BCM	GRCh38.p13	chr5	5239253	5239253	+	A	A	G	Missense_Mutation	SNP	ENST00000274181.7	exon15	c.A2257G	p.T753A	exonic	ENSG00000145536.15	.	nonsynonymous SNV	ENSG00000145536.15:ENST00000274181.7:exon15:c.A2257G:p.T753A	5p15.32	C3L-00625	4.38e-05	0	0	0	0	0	0	0.0004	rs752177133	0.20	T	T	B	B	N	N	N	T	N	0.085	T	T	T	0.078	0.587	0.355	0.162	T	T	T	T	T	T	0.883	10.260	0.318	N	N	-1.540	0.070	-1.491	0.111	0.999	0.644	0.588	0.688	0.564	.	5.850	-4.170	0.905	-0.426	-0.582	0.983	0.281	0.571	933	ADAM-TS_Spacer_1	.	.	.	ADAMTS16	36	0	61	6	0.0895522388059701	TRUE	NA
ENSG00000043462.12	.	BCM	GRCh38.p13	chr5	170297587	170297587	+	G	G	A	Missense_Mutation	SNP	ENST00000046794.10	exon1	c.C25T	p.R9C	exonic	ENSG00000043462.12	.	nonsynonymous SNV	ENSG00000043462.12:ENST00000046794.10:exon1:c.C25T:p.R9C	5q35.1	C3L-00625	1.037e-05	0	0	0	0	1.837e-05	0	0	rs752977011	13.20	T	T	D	P	D	D	M	T	D	0.683	T	T	D	0.202	0.384	0.820	0.828	T	D	D	D	D	D	3.980	26.800	0.999	D	D	0.535	5.322	0.574	5.912	1.000	0.497	0.522	0.547	0.542	.	5.440	5.440	5.833	1.176	0.676	1.000	1.000	0.996	613	.	.	.	ID=COSV50455905;OCCURENCE=1(prostate)	LCP2	71	0	188	29	0.133640552995392	TRUE	TRUE
ENSG00000118432.12	.	BCM	GRCh38.p13	chr6	88144390	88144390	+	C	C	A	Missense_Mutation	SNP	ENST00000369501.2	exon2	c.G885T	p.M295I	exonic	ENSG00000118432.12	.	nonsynonymous SNV	ENSG00000118432.12:ENST00000369501.2:exon2:c.G885T:p.M295I	6q15	C3L-00625	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	N	T	N	0.320	T	T	T	0.171	0.494	0.892	.	T	T	T	T	D	D	1.509	15.790	0.865	D	N	-0.246	1.751	-0.027	2.270	0.363	0.554	0.546	0.602	0.564	.	6.050	5.110	2.549	1.026	0.599	1.000	0.958	0.773	442	GPCR,_rhodopsin-like,_7TM	.	.	.	CNR1	201	0	360	82	0.18552036199095	TRUE	TRUE
ENSG00000065675.15	.	BCM	GRCh38.p13	chr10	6515059	6515059	+	T	T	A	Missense_Mutation	SNP	ENST00000263125.10	exon2	c.A77T	p.N26I	exonic	ENSG00000065675.15	.	nonsynonymous SNV	ENSG00000065675.15:ENST00000263125.10:exon2:c.A77T:p.N26I	10p15.1	C3L-00625	.	.	.	.	.	.	.	.	.	9.20	D	D	P	B	D	D	L	T	D	0.849	T	T	D	0.279	0.708	0.750	0.576	T	T	T	T	D	D	2.758	22.900	0.988	D	N	-0.054	2.324	-0.026	2.274	1.000	0.706	0.590	0.710	0.621	.	5.200	1.560	2.172	1.138	0.665	1.000	0.944	0.893	911	.	.	.	.	PRKCQ	209	0	415	62	0.129979035639413	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-00625	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	265	0	483	91	0.158536585365854	TRUE	TRUE
ENSG00000170456.16	.	BCM	GRCh38.p13	chr12	31479678	31479678	+	C	C	T	Missense_Mutation	SNP	ENST00000389082.10	exon3	c.G815A	p.R272Q	exonic	ENSG00000170456.16	.	nonsynonymous SNV	ENSG00000170456.16:ENST00000389082.10:exon3:c.G815A:p.R272Q	12p11.21	C3L-00625	2.183e-05	0	0	0.0003	0	0	0	0	rs765700922	2.20	T	T	B	B	N	N	L	T	D	0.201	T	T	T	0.068	.	0.357	0.644	T	T	T	T	T	D	1.617	16.480	0.995	N	N	-0.687	0.834	-0.653	0.968	1.000	0.507	0.658	0.567	0.636	.	4.560	3.680	1.131	1.026	0.599	0.000	0.066	0.290	951	Tripartite_DENN_domain;cDENN_domain	.	.	.	DENND5B	35	0	102	20	0.163934426229508	TRUE	NA
ENSG00000135480.16	.	BCM	GRCh38.p13	chr12	52233465	52233465	+	G	G	A	Missense_Mutation	SNP	ENST00000331817.6	exon1	c.G169A	p.G57S	exonic	ENSG00000135480.16	.	nonsynonymous SNV	ENSG00000135480.16:ENST00000331817.6:exon1:c.G169A:p.G57S	12q13.13	C3L-00625	.	.	.	.	.	.	.	.	.	3.19	T	D	B	B	.	N	L	T	D	0.041	T	T	D	0.178	0.342	0.365	0.279	T	T	T	T	T	T	0.575	7.272	0.993	N	N	-0.706	0.803	-0.768	0.803	1.000	0.733	0.563	0.619	0.622	.	4.480	2.650	-0.688	-0.173	-0.162	0.000	0.001	0.001	749	Keratin_type_II_head	.	.	.	KRT7	162	2	449	117	0.206713780918728	TRUE	TRUE
ENSG00000198838.13	.	BCM	GRCh38.p13	chr15	33697980	33697980	+	G	G	C	Missense_Mutation	SNP	ENST00000634891.1	exon40	c.G6233C	p.G2078A	exonic	ENSG00000198838.13	.	nonsynonymous SNV	ENSG00000198838.13:ENST00000634891.1:exon40:c.G6233C:p.G2078A	15q14	C3L-00625	.	.	.	.	.	.	.	.	.	16.19	D	.	B	B	D	D	M	D	D	0.554	D	D	D	0.561	0.633	0.804	0.358	T	D	D	D	D	D	3.459	24.600	0.994	D	D	0.222	3.402	0.390	4.287	1.000	0.447	0.563	0.547	0.530	.	5.100	5.100	10.003	1.176	0.676	1.000	0.994	0.963	955	RIH_domain	.	.	.	RYR3	162	0	295	45	0.132352941176471	TRUE	TRUE
ENSG00000196557.13	.	BCM	GRCh38.p13	chr16	1211566	1211566	+	G	G	A	Missense_Mutation	SNP	ENST00000348261.11	exon23	c.G4436A	p.R1479H	exonic	ENSG00000196557.13	.	nonsynonymous SNV	ENSG00000196557.13:ENST00000348261.11:exon23:c.G4436A:p.R1479H	16p13.3	C3L-00625	1.826e-05	0	0	0.0001	0	0	0	6.344e-05	rs776023990	17.20	D	D	D	D	D	N	M	D	D	0.531	D	D	D	0.602	0.618	0.951	.	T	D	D	D	D	D	4.214	28.800	0.999	D	N	0.525	5.238	0.458	4.798	0.005	0.696	0.547	0.723	0.563	.	3.990	3.990	1.639	1.074	0.618	1.000	1.000	0.993	934	Ion_transport_domain	.	.	ID=COSV62000838;OCCURENCE=1(stomach),1(pancreas)	CACNA1H	88	0	340	27	0.0735694822888283	TRUE	TRUE
ENSG00000103249.18	.	BCM	GRCh38.p13	chr16	1455768	1455768	+	C	C	T	Missense_Mutation	SNP	ENST00000382745.9	exon11	c.G944A	p.G315D	exonic	ENSG00000103249.18	.	nonsynonymous SNV	ENSG00000103249.18:ENST00000382745.9:exon11:c.G944A:p.G315D	16p13.3	C3L-00625	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.873	D	D	D	0.894	0.703	0.960	1.777	D	D	D	D	D	D	3.264	24.000	0.998	D	D	0.579	5.716	0.461	4.825	1.000	0.732	0.744	0.723	0.714	.	5.130	5.130	4.679	1.026	0.549	1.000	0.951	0.183	783	.	.	.	.	CLCN7	307	0	677	107	0.136479591836735	TRUE	NA
ENSG00000172840.7	.	BCM	GRCh38.p13	chr16	66884385	66884385	+	G	G	A	Missense_Mutation	SNP	ENST00000311765.4	exon2	c.G101A	p.R34K	exonic	ENSG00000172840.7	.	nonsynonymous SNV	ENSG00000172840.7:ENST00000311765.4:exon2:c.G101A:p.R34K	16q22.1	C3L-00625	.	.	.	.	.	.	.	.	.	3.20	D	T	B	B	N	N	M	T	N	0.250	T	T	T	0.048	0.351	0.676	0.274	T	T	T	T	T	T	1.975	19.070	0.955	D	N	-0.478	1.220	-0.391	1.388	0.999	0.707	0.725	0.725	0.636	.	5.420	3.430	3.474	1.176	0.676	0.970	0.093	0.952	87	.	.	.	.	PDP2	108	0	330	51	0.133858267716535	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674187	7674187	+	T	T	A	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.A776T	p.D259V	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.A776T:p.D259V	17p13.1	C3L-00625	.	.	.	.	.	.	.	.	.	15.20	D	D	P	P	D	D	M	D	N	0.696	D	D	D	0.742	0.567	0.975	0.450	T	D	D	D	D	D	3.733	25.500	0.993	D	N	0.305	3.804	0.259	3.489	0.010	0.722	0.702	0.725	0.735	.	4.520	4.520	3.211	1.136	0.665	1.000	0.997	0.678	432	p53,_DNA-binding_domain	.	.	ID=COSV52679505;OCCURENCE=2(breast),2(liver),1(large_intestine),1(central_nervous_system),3(ovary),1(haematopoietic_and_lymphoid_tissue),2(stomach),1(soft_tissue),4(urinary_tract),3(pancreas),2(skin),5(lung)	TP53	216	0	394	78	0.165254237288136	TRUE	TRUE
ENSG00000176845.13	.	BCM	GRCh38.p13	chr17	83085313	83085313	+	C	C	A	Missense_Mutation	SNP	ENST00000320095.12	exon2	c.C546A	p.H182Q	exonic	ENSG00000176845.13	.	nonsynonymous SNV	ENSG00000176845.13:ENST00000320095.12:exon2:c.C546A:p.H182Q	17q25.3	C3L-00625	.	.	.	.	.	.	.	.	.	3.19	T	T	D	P	N	N	L	.	D	0.375	T	T	T	0.125	0.150	0.151	0.594	T	T	T	T	D	T	-0.140	0.684	0.836	N	N	-0.883	0.542	-1.095	0.380	1.000	0.707	0.693	0.723	0.714	.	4.100	-3.360	-0.217	-0.797	-1.606	0.000	0.000	0.000	.	.	.	.	.	METRNL	13	0	27	9	0.25	TRUE	TRUE
ENSG00000063177.13	.	BCM	GRCh38.p13	chr19	48616112	48616112	+	A	A	G	Missense_Mutation	SNP	ENST00000549920.6	exon5	c.T388C	p.S130P	exonic	ENSG00000063177.13	.	nonsynonymous SNV	ENSG00000063177.13:ENST00000549920.6:exon5:c.T388C:p.S130P	19q13.33	C3L-00625	.	.	.	.	.	.	.	.	.	14.19	D	D	P	P	D	D	M	.	D	0.404	T	T	D	0.389	0.695	0.591	1.044	T	D	D	D	D	D	3.577	25.000	0.998	D	D	0.225	3.418	0.238	3.377	1.000	0.722	0.696	0.699	0.735	.	5.250	4.170	1.175	1.307	0.686	0.999	1.000	0.987	735	Ribosomal_protein_L18e/L15P	.	.	.	RPL18	180	0	432	93	0.177142857142857	TRUE	TRUE
ENSG00000126945.9	.	BCM	GRCh38.p13	chrX	101412622	101412622	+	A	A	T	Missense_Mutation	SNP	ENST00000316594.6	exon2	c.A634T	p.R212W	exonic	ENSG00000126945.9	.	nonsynonymous SNV	ENSG00000126945.9:ENST00000316594.6:exon2:c.A634T:p.R212W	Xq22.1	C3L-00625	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	M	T	D	0.614	T	T	D	0.370	0.450	0.910	2.776	D	D	D	T	D	D	4.027	27.200	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.880	4.880	3.385	1.290	0.751	1.000	1.000	0.997	125	.	.	.	.	HNRNPH2	203	0	457	96	0.173598553345389	TRUE	TRUE
ENSG00000204099.11	.	BCM	GRCh38.p13	chr2	241814523	241814523	+	C	C	T	Silent	SNP	ENST00000391969.6	exon3	c.C39T	p.F13F	exonic	ENSG00000204099.11	.	synonymous SNV	ENSG00000204099.11:ENST00000391969.6:exon3:c.C39T:p.F13F	2q37.3	C3L-00625	.	.	.	.	.	.	.	.	rs920176159	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57990448;OCCURENCE=1(large_intestine),1(skin),1(lung)	NEU4	176	0	439	57	0.11491935483871	TRUE	TRUE
ENSG00000121871.4	.	BCM	GRCh38.p13	chr3	165187939	165187939	+	C	C	T	Silent	SNP	ENST00000475390.2	exon2	c.G2892A	p.P964P	exonic	ENSG00000121871.4	.	synonymous SNV	ENSG00000121871.4:ENST00000475390.2:exon2:c.G2892A:p.P964P	3q26.1	C3L-00625	8.254e-06	0	0	0	0	1.502e-05	0	0	rs781561672	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53850899;OCCURENCE=1(large_intestine),1(endometrium)	SLITRK3	82	0	165	35	0.175	TRUE	TRUE
ENSG00000159788.19	.	BCM	GRCh38.p13	chr4	3317952	3317952	+	G	G	A	Silent	SNP	ENST00000344733.9	exon2	c.G1782A	p.P594P	exonic	ENSG00000159788.19	.	synonymous SNV	ENSG00000159788.19:ENST00000344733.9:exon2:c.G1782A:p.P594P	4p16.3	C3L-00625	8.284e-06	0	0	0	0	1.506e-05	0	0	rs751083722	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RGS12	157	0	284	45	0.13677811550152	TRUE	NA
ENSG00000188848.16	.	BCM	GRCh38.p13	chr4	42143855	42143855	+	G	G	A	Silent	SNP	ENST00000502486.6	exon3	c.C627T	p.N209N	exonic	ENSG00000188848.16	.	synonymous SNV	ENSG00000188848.16:ENST00000502486.6:exon3:c.C627T:p.N209N	4p13	C3L-00625	1.882e-05	0.0001	0	0	0	0	0	0.0001	rs574971489	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV72468915;OCCURENCE=1(large_intestine),2(upper_aerodigestive_tract),1(endometrium)	BEND4	29	0	92	15	0.14018691588785	TRUE	TRUE
ENSG00000183072.10	.	BCM	GRCh38.p13	chr5	173232908	173232908	+	C	C	A	Silent	SNP	ENST00000329198.5	exon2	c.G636T	p.P212P	exonic	ENSG00000183072.10	.	synonymous SNV	ENSG00000183072.10:ENST00000329198.5:exon2:c.G636T:p.P212P	5q35.1	C3L-00625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NKX2-5	348	0	820	147	0.152016546018614	NA	TRUE
ENSG00000196787.3	.	BCM	GRCh38.p13	chr6	27133338	27133338	+	C	C	T	Silent	SNP	ENST00000359193.3	exon1	c.C267T	p.R89R	exonic	ENSG00000196787.3	.	synonymous SNV	ENSG00000196787.3:ENST00000359193.3:exon1:c.C267T:p.R89R	6p22.1	C3L-00625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	H2AC11	383	1	791	83	0.0949656750572082	NA	TRUE
ENSG00000105877.18	.	BCM	GRCh38.p13	chr7	21786692	21786692	+	G	G	A	Silent	SNP	ENST00000409508.8	exon59	c.G9666A	p.V3222V	exonic	ENSG00000105877.18	.	synonymous SNV	ENSG00000105877.18:ENST00000409508.8:exon59:c.G9666A:p.V3222V	7p15.3	C3L-00625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH11	150	0	255	55	0.17741935483871	TRUE	TRUE
ENSG00000086288.12	.	BCM	GRCh38.p13	chr7	37862069	37862069	+	G	G	A	Silent	SNP	ENST00000199447.9	exon7	c.G312A	p.P104P	exonic	ENSG00000086288.12	.	synonymous SNV	ENSG00000086288.12:ENST00000199447.9:exon7:c.G312A:p.P104P	7p14.1	C3L-00625	3.31e-05	0.0002	0	0.0002	0	0	0	0	rs536359204	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52246470;OCCURENCE=1(large_intestine),1(pancreas),2(endometrium)	NME8	277	0	472	93	0.164601769911504	TRUE	TRUE
ENSG00000167034.10	.	BCM	GRCh38.p13	chr8	23681332	23681332	+	C	C	T	Silent	SNP	ENST00000380871.5	exon2	c.G594A	p.P198P	exonic	ENSG00000167034.10	.	synonymous SNV	ENSG00000167034.10:ENST00000380871.5:exon2:c.G594A:p.P198P	8p21.2	C3L-00625	0.0008	0.0088	8.637e-05	0	0	0	0	0	rs35675040	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66512512;OCCURENCE=2(large_intestine)	NKX3-1	165	0	296	64	0.177777777777778	TRUE	TRUE
ENSG00000179698.14	.	BCM	GRCh38.p13	chr8	144109157	144109157	+	C	C	T	Silent	SNP	ENST00000323662.9	exon4	c.C987T	p.F329F	exonic	ENSG00000179698.14	.	synonymous SNV	ENSG00000179698.14:ENST00000323662.9:exon4:c.C987T:p.F329F	8q24.3	C3L-00625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WDR97	172	0	426	90	0.174418604651163	TRUE	TRUE
ENSG00000148219.16	.	BCM	GRCh38.p13	chr9	116620360	116620360	+	G	G	A	Silent	SNP	ENST00000313400.8	exon18	c.C3156T	p.S1052S	exonic	ENSG00000148219.16	.	synonymous SNV	ENSG00000148219.16:ENST00000313400.8:exon18:c.C3156T:p.S1052S	9q33.1	C3L-00625	0.0044	0.0008	0.0021	0	0.0008	0.0036	0.0022	0.0156	rs143407265	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56011825;OCCURENCE=1(oesophagus)	ASTN2	252	0	508	76	0.13013698630137	TRUE	TRUE
ENSG00000165458.14	.	BCM	GRCh38.p13	chr11	72231599	72231599	+	C	C	T	Silent	SNP	ENST00000298229.7	exon13	c.C1599T	p.G533G	exonic	ENSG00000165458.14	.	synonymous SNV	ENSG00000165458.14:ENST00000298229.7:exon13:c.C1599T:p.G533G	11q13.4	C3L-00625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INPPL1	167	0	341	72	0.174334140435835	TRUE	TRUE
ENSG00000170967.5	.	BCM	GRCh38.p13	chr11	104036843	104036843	+	C	C	T	Silent	SNP	ENST00000302259.5	exon1	c.C21T	p.C7C	exonic	ENSG00000170967.5	.	synonymous SNV	ENSG00000170967.5:ENST00000302259.5:exon1:c.C21T:p.C7C	11q22.3	C3L-00625	8.41e-06	0	8.672e-05	0	0	0	0	0	rs777102812	2.12	D	.	.	.	.	D	.	T	N	.	T	T	.	0.174	0.240	0.110	.	.	.	T	T	T	T	0.339	4.744	0.910	N	N	-1.078	0.326	-1.222	0.265	0.995	0.487	0.574	0.547	0.564	.	5.080	-10.200	0.120	-2.047	-0.800	0.980	0.886	0.837	912	.	.	.	ID=COSV56395204;OCCURENCE=1(large_intestine),1(kidney)	DDI1	103	0	203	56	0.216216216216216	TRUE	TRUE
ENSG00000141431.12	.	BCM	GRCh38.p13	chr18	33746316	33746316	+	A	A	C	Silent	SNP	ENST00000269197.12	exon12	c.A6468C	p.T2156T	exonic	ENSG00000141431.12	.	synonymous SNV	ENSG00000141431.12:ENST00000269197.12:exon12:c.A6468C:p.T2156T	18q12.1	C3L-00625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ASXL3	173	0	303	52	0.146478873239437	TRUE	TRUE
ENSG00000078747.15	.	BCM	GRCh38.p13	chr20	34445353	34445353	+	G	G	A	Silent	SNP	ENST00000665346.1	exon12	c.G1155A	p.T385T	exonic	ENSG00000078747.15	.	synonymous SNV	ENSG00000078747.15:ENST00000665346.1:exon12:c.G1155A:p.T385T	20q11.22	C3L-00625	9.061e-05	0	0.0003	0	0	8.991e-05	0	6.056e-05	rs201221876	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITCH	241	0	522	181	0.2574679943101	TRUE	NA
ENSG00000115592.11	.	BCM	GRCh38.p13	chr2	218827890	218827890	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000115592.11	.	.	.	2q35	C3L-00625	8.492e-06	0	0	0	0	1.534e-05	0	0	rs753669652	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRKAG3	330	0	633	111	0.149193548387097	TRUE	NA
ENSG00000204529.4	.	BCM	GRCh38.p13	chr11	76716427	76716427	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000204529.4	.	.	.	11q13.5	C3L-00625	0.0261	0.0625	0.0111	0	.	0.0066	0.0603	0.0323	rs56136160	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GUCY2EP	97	0	171	27	0.136363636363636	TRUE	NA
ENSG00000169446.5	.	BCM	GRCh38.p13	chrX	135973927	135973927	+	G	G	C	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000169446.5	ENST00000305963.2:c.-252C>G	.	.	Xq26.3	C3L-00625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MMGT1	352	0	818	101	0.109902067464635	TRUE	NA
ENSG00000131697.18	.	BCM	GRCh38.p13	chr1	5877103	5877103	+	G	G	A	Missense_Mutation	SNP	ENST00000378156.9	exon20	c.C2807T	p.T936M	exonic	ENSG00000131697.18	.	nonsynonymous SNV	ENSG00000131697.18:ENST00000378156.9:exon20:c.C2807T:p.T936M	1p36.31	C3N-03754	0.0005	0	0.0050	0	0	4.948e-05	0	0	rs201074950	2.20	T	T	P	B	N	N	L	D	N	0.185	T	T	D	0.294	.	0.862	0.084	T	T	T	T	T	T	1.157	13.290	0.955	N	N	-0.611	0.967	-0.763	0.810	0.290	0.646	0.602	0.645	0.655	.	4.670	0.156	0.073	-0.105	0.676	0.000	0.000	0.002	952	.	.	.	.	NPHP4	85	0	59	6	0.0923076923076923	TRUE	NA
ENSG00000163053.11	.	BCM	GRCh38.p13	chr2	230045936	230045936	+	A	A	G	Missense_Mutation	SNP	ENST00000295190.9	exon4	c.T1190C	p.F397S	exonic	ENSG00000163053.11	.	nonsynonymous SNV	ENSG00000163053.11:ENST00000295190.9:exon4:c.T1190C:p.F397S	2q36.3	C3N-03754	.	.	.	.	.	.	.	.	.	6.20	D	D	P	P	N	N	L	T	N	0.493	T	T	D	0.335	0.688	0.627	1.454	T	T	T	T	D	T	3.996	26.900	0.998	D	D	0.193	3.272	0.212	3.242	0.456	0.638	0.670	0.659	0.564	.	4.820	4.820	5.094	1.312	0.756	0.998	0.981	0.998	952	Major_facilitator_superfamily_domain	.	.	.	SLC16A14	91	0	49	5	0.0925925925925926	TRUE	TRUE
ENSG00000163930.10	.	BCM	GRCh38.p13	chr3	52404550	52404550	+	G	G	A	Nonsense_Mutation	SNP	ENST00000460680.6	exon12	c.C1153T	p.R385X	exonic	ENSG00000163930.10	.	stopgain	ENSG00000163930.10:ENST00000460680.6:exon12:c.C1153T:p.R385X	3p21.1	C3N-03754	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.959	.	.	.	.	.	.	.	.	.	D	D	.	.	6.594	36	0.998	D	N	0.734	7.615	0.599	6.215	1.000	0.707	0.698	0.698	0.714	.	5.540	4.660	3.061	1.176	0.676	1.000	1.000	0.998	68	Peptidase_C12,_ubiquitin_carboxyl-terminal_hydrolase	.	.	ID=COSV56230370;OCCURENCE=1(large_intestine),1(stomach),1(kidney),1(pancreas),2(lung),4(eye)	BAP1	385	0	272	54	0.165644171779141	TRUE	TRUE
ENSG00000185049.16	.	BCM	GRCh38.p13	chr4	1989747	1989747	+	G	G	T	Missense_Mutation	SNP	ENST00000382882.9	exon3	c.C505A	p.P169T	exonic	ENSG00000185049.16	.	nonsynonymous SNV	ENSG00000185049.16:ENST00000382882.9:exon3:c.C505A:p.P169T	4p16.3	C3N-03754	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	L	T	D	0.939	T	T	D	0.629	0.512	0.926	1.991	D	T	D	D	D	D	4.053	27.400	0.998	D	D	0.880	10.552	0.835	11.251	1.000	0.707	0.725	0.571	0.714	.	4.960	4.960	9.836	1.152	0.650	1.000	0.997	0.993	759	Hepatitis_delta_antigen_(HDAg)_domain	.	.	.	NELFA	132	0	88	20	0.185185185185185	TRUE	TRUE
ENSG00000132842.14	.	BCM	GRCh38.p13	chr5	78128070	78128070	+	G	G	A	Missense_Mutation	SNP	ENST00000255194.11	exon17	c.C1928T	p.A643V	exonic	ENSG00000132842.14	.	nonsynonymous SNV	ENSG00000132842.14:ENST00000255194.11:exon17:c.C1928T:p.A643V	5q14.1	C3N-03754	4.948e-05	0.0004	0	0	0	2.999e-05	0	0	rs769622520	11.20	T	D	P	B	D	D	M	T	D	0.795	T	T	D	0.404	.	0.415	0.067	T	D	T	T	D	D	3.404	24.400	0.995	D	D	0.651	6.483	0.677	7.351	1.000	0.758	0.630	0.692	0.584	.	5.910	5.040	10.003	1.176	0.676	1.000	1.000	0.998	893	.	.	.	.	AP3B1	409	1	205	28	0.120171673819742	TRUE	NA
ENSG00000081842.18	.	BCM	GRCh38.p13	chr5	140830027	140830027	+	C	C	T	Missense_Mutation	SNP	ENST00000529310.6	exon1	c.C1936T	p.R646W	exonic	ENSG00000081842.18	.	nonsynonymous SNV	ENSG00000081842.18:ENST00000529310.6:exon1:c.C1936T:p.R646W	5q31.3	C3N-03754	2.493e-05	0	0	0.0001	0	3.025e-05	0	0	rs782267488	8.19	D	D	D	P	U	N	M	T	D	0.467	T	T	D	0.111	0.591	0.688	1.577	.	T	T	T	D	D	3.201	23.900	0.997	N	N	-0.083	2.230	-0.348	1.468	0.000	0.581	0.574	0.578	0.605	.	3.980	1.960	1.629	0.941	0.327	0.002	0.005	0.336	30	Cadherin-like	.	.	.	PCDHA6	493	0	409	70	0.146137787056367	TRUE	NA
ENSG00000015676.18	.	BCM	GRCh38.p13	chr7	44490599	44490599	+	A	A	C	Translation_Start_Site	SNP	ENST00000355451.8	exon1	c.T2G	p.M1?	exonic	ENSG00000015676.18	.	startloss	ENSG00000015676.18:ENST00000355451.8:exon1:c.T2G:p.M1?	7p13	C3N-03754	.	.	.	.	.	.	.	.	rs373463207	9.18	D	D	P	P	D	D	.	T	N	0.932	T	T	D	0.434	0.988	0.807	.	.	T	D	D	D	D	3.761	25.700	0.969	N	N	0.382	4.231	0.317	3.817	1.000	0.468	0.504	0.504	0.273	.	4.440	4.440	5.685	1.298	0.756	1.000	0.262	0.028	783	.	.	.	.	NUDCD3	130	0	125	28	0.183006535947712	TRUE	NA
ENSG00000085563.15	.	BCM	GRCh38.p13	chr7	87545961	87545961	+	C	C	T	Missense_Mutation	SNP	ENST00000622132.5	exon15	c.G1789A	p.V597I	exonic	ENSG00000085563.15	.	nonsynonymous SNV	ENSG00000085563.15:ENST00000622132.5:exon15:c.G1789A:p.V597I	7q21.12	C3N-03754	0.0001	0	0	0.0001	0	1.499e-05	0	0.0007	rs199931362	5.19	T	T	B	B	D	D	N	D	N	0.139	T	T	D	0.326	0.389	0.375	0.169	T	.	T	T	T	T	0.887	10.300	0.995	D	N	-0.277	1.672	-0.094	2.064	0.038	0.638	0.588	0.618	0.668	.	5.730	5.730	0.177	0.129	-0.171	0.035	0.989	0.919	500	ABC_transporter-like;AAA+_ATPase_domain	.	.	ID=COSV55952252;OCCURENCE=1(large_intestine),1(central_nervous_system),1(stomach)	ABCB1	251	0	142	14	0.0897435897435897	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21974696	21974696	+	-	NA	T	Nonsense_Mutation	SNP	ENST00000304494.9	exon1	c.131dupA	p.Y44*	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon1:c.131dupA:p.Y44*	9p21.3	C3N-03754	8.457e-06	0	0	0	0	1.547e-05	0	0	rs730881673	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	NA	NA	NA	NA	NA	NA	NA
ENSG00000106772.18	.	BCM	GRCh38.p13	chr9	76636481	76636481	+	G	G	T	Missense_Mutation	SNP	ENST00000376718.8	exon15	c.C9040A	p.P3014T	exonic	ENSG00000106772.18	.	nonsynonymous SNV	ENSG00000106772.18:ENST00000376718.8:exon15:c.C9040A:p.P3014T	9q21.2	C3N-03754	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.836	D	D	D	0.573	0.644	0.582	0.480	T	T	D	D	D	D	4.110	27.800	0.997	D	D	0.628	6.221	0.633	6.663	1.000	0.706	0.588	0.659	0.613	.	4.790	4.790	9.388	1.083	0.676	1.000	0.999	0.992	945	CRAL-TRIO_lipid_binding_domain	.	.	.	PRUNE2	135	0	42	7	0.142857142857143	TRUE	TRUE
ENSG00000150275.18	.	BCM	GRCh38.p13	chr10	54317293	54317293	+	G	G	A	Missense_Mutation	SNP	ENST00000320301.10	exon8	c.C854T	p.A285V	exonic	ENSG00000150275.18	.	nonsynonymous SNV	ENSG00000150275.18:ENST00000320301.10:exon8:c.C854T:p.A285V	10q21.1	C3N-03754	1.649e-05	0	0	0	0	2.999e-05	0	0	rs768148484	1.19	T	T	B	B	.	N	N	T	N	0.194	T	T	T	0.088	0.277	0.583	0.028	T	T	T	T	T	D	1.903	18.510	0.945	N	N	-0.299	1.616	-0.165	1.871	0.000	0.554	0.574	0.574	0.621	.	4.770	3.790	0.427	1.176	0.674	0.007	0.997	1.000	921	.	.	.	ID=COSV57374240;OCCURENCE=1(endometrium)	PCDH15	398	1	270	26	0.0878378378378378	TRUE	TRUE
ENSG00000165443.12	.	BCM	GRCh38.p13	chr10	59245578	59245578	+	G	G	T	Missense_Mutation	SNP	ENST00000373880.9	exon5	c.G1118T	p.S373I	exonic	ENSG00000165443.12	.	nonsynonymous SNV	ENSG00000165443.12:ENST00000373880.9:exon5:c.G1118T:p.S373I	10q21.1	C3N-03754	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	N	0.724	T	T	D	0.486	0.528	0.765	1.358	D	T	D	D	D	D	3.955	26.700	0.995	D	D	0.801	8.797	0.810	10.432	1.000	0.487	0.574	0.547	0.564	.	5.380	5.380	9.998	1.176	0.676	1.000	1.000	0.999	982	.	.	.	.	PHYHIPL	73	0	26	9	0.257142857142857	TRUE	TRUE
ENSG00000205030.1	.	BCM	GRCh38.p13	chr11	55827567	55827567	+	G	G	A	Missense_Mutation	SNP	ENST00000378397.1	exon1	c.G349A	p.V117M	exonic	ENSG00000205030.1	.	nonsynonymous SNV	ENSG00000205030.1:ENST00000378397.1:exon1:c.G349A:p.V117M	11q12.1	C3N-03754	1.649e-05	0	8.666e-05	0	0	0	0	6.061e-05	rs202214388	4.20	D	D	B	B	D	N	M	T	N	0.114	T	T	T	0.080	0.246	0.486	0.013	T	T	T	T	T	T	1.792	17.670	0.992	N	N	-0.215	1.836	-0.236	1.702	0.000	0.487	0.574	0.574	0.564	.	4.650	2.750	1.776	0.068	-0.237	0.012	0.256	0.821	162	GPCR,_rhodopsin-like,_7TM	.	.	.	OR5L2	283	0	172	42	0.196261682242991	NA	TRUE
ENSG00000110448.11	.	BCM	GRCh38.p13	chr11	61118254	61118254	+	G	G	T	Missense_Mutation	SNP	ENST00000347785.8	exon3	c.G174T	p.M58I	exonic	ENSG00000110448.11	.	nonsynonymous SNV	ENSG00000110448.11:ENST00000347785.8:exon3:c.G174T:p.M58I	11q12.2	C3N-03754	.	.	.	.	.	.	.	.	.	1.20	D	T	B	B	N	N	L	T	N	0.118	T	T	T	0.042	0.630	0.278	0.319	T	T	T	T	T	T	-1.475	0.001	0.911	N	N	-1.626	0.050	-1.786	0.036	0.992	0.554	0.588	0.547	0.542	.	3.990	-7.990	-7.697	-0.921	-0.113	0.000	0.108	0.358	297	SRCR_domain;SRCR-like_domain	.	.	.	CD5	399	2	264	62	0.190184049079755	TRUE	TRUE
ENSG00000168014.16	.	BCM	GRCh38.p13	chr11	74103367	74103367	+	C	C	T	Missense_Mutation	SNP	ENST00000334126.11	exon14	c.G2344A	p.V782I	exonic	ENSG00000168014.16	.	nonsynonymous SNV	ENSG00000168014.16:ENST00000334126.11:exon14:c.G2344A:p.V782I	11q13.4	C3N-03754	0.0008	0.0093	8.64e-05	0	0	0	0	0	rs147717518	0.19	T	T	B	B	N	N	L	T	N	0.150	T	T	.	0.012	.	0.102	0.079	T	T	T	T	T	T	-0.223	0.456	0.706	N	N	-1.212	0.219	-1.222	0.265	0.002	0.563	0.654	0.609	0.636	.	5.600	-0.535	-0.154	-0.180	-0.153	0.000	0.020	0.008	461	.	.	.	.	C2CD3	310	0	236	23	0.0888030888030888	TRUE	NA
ENSG00000183560.9	.	BCM	GRCh38.p13	chr11	94306692	94306692	+	G	G	C	Missense_Mutation	SNP	ENST00000328458.5	exon2	c.G318C	p.W106C	exonic	ENSG00000183560.9	.	nonsynonymous SNV	ENSG00000183560.9:ENST00000328458.5:exon2:c.G318C:p.W106C	11q21	C3N-03754	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.963	D	D	D	0.882	0.934	0.776	0.198	T	D	D	D	D	D	4.445	31	0.992	D	D	0.919	11.549	0.848	11.705	1.000	0.578	0.590	0.608	0.564	.	4.750	4.750	9.638	1.172	0.676	1.000	0.970	0.881	749	Folate_receptor-like	.	.	.	IZUMO1R	374	1	335	29	0.0796703296703297	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-03754	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	279	0	136	25	0.15527950310559	TRUE	TRUE
ENSG00000111602.12	.	BCM	GRCh38.p13	chr12	56423687	56423687	+	G	G	C	Missense_Mutation	SNP	ENST00000553532.6	exon17	c.C1987G	p.R663G	exonic	ENSG00000111602.12	.	nonsynonymous SNV	ENSG00000111602.12:ENST00000553532.6:exon17:c.C1987G:p.R663G	12q13.3	C3N-03754	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.073	T	T	T	0.038	0.248	0.148	0.150	T	T	T	T	T	T	0.268	3.911	0.270	N	N	-1.641	0.047	-1.581	0.081	0.002	0.707	0.725	0.725	0.636	.	5.610	1.690	0.713	-1.278	-1.790	0.001	0.050	0.071	140	.	.	.	.	TIMELESS	210	1	128	45	0.260115606936416	TRUE	NA
ENSG00000090060.18	.	BCM	GRCh38.p13	chr14	96537020	96537020	+	T	T	C	Missense_Mutation	SNP	ENST00000216277.12	exon12	c.T1075C	p.S359P	exonic	ENSG00000090060.18	.	nonsynonymous SNV	ENSG00000090060.18:ENST00000216277.12:exon12:c.T1075C:p.S359P	14q32.2	C3N-03754	.	.	.	.	.	.	.	.	.	7.19	T	T	B	B	D	D	L	.	N	0.524	T	T	T	0.167	0.561	0.535	1.506	D	T	T	T	D	D	2.783	23.000	0.993	D	D	0.007	2.536	0.166	3.022	1.000	0.732	0.725	0.710	0.728	.	5.010	5.010	4.699	1.138	0.665	1.000	1.000	1.000	963	Poly(A)_polymerase,_central_domain	.	.	.	PAPOLA	185	0	40	4	0.0909090909090909	TRUE	TRUE
ENSG00000177548.13	.	BCM	GRCh38.p13	chr16	28904986	28904986	+	T	T	C	Missense_Mutation	SNP	ENST00000358201.9	exon13	c.A1667G	p.D556G	exonic	ENSG00000177548.13	.	nonsynonymous SNV	ENSG00000177548.13:ENST00000358201.9:exon13:c.A1667G:p.D556G	16p11.2	C3N-03754	.	.	.	.	.	.	.	.	rs547755398	7.20	T	D	D	D	N	N	L	T	D	0.390	T	T	D	0.133	0.193	0.650	0.272	T	T	T	T	D	T	3.133	23.700	0.985	D	N	0.021	2.588	0.082	2.663	0.048	0.707	0.702	0.723	0.714	.	4.490	4.490	3.101	1.127	0.595	0.995	0.955	0.612	375	.	.	.	.	RABEP2	175	0	161	27	0.143617021276596	TRUE	NA
ENSG00000103494.14	.	BCM	GRCh38.p13	chr16	53687950	53687950	+	T	T	A	Missense_Mutation	SNP	ENST00000647211.2	exon5	c.A545T	p.D182V	exonic	ENSG00000103494.14	.	nonsynonymous SNV	ENSG00000103494.14:ENST00000647211.2:exon5:c.A545T:p.D182V	16q12.2	C3N-03754	.	.	.	.	.	.	.	.	.	10.20	D	D	B	B	N	D	L	D	D	0.359	T	T	D	0.422	0.296	0.615	0.189	T	T	D	T	D	D	2.799	23.000	0.976	D	N	-0.330	1.543	-0.188	1.814	0.956	0.615	0.588	0.659	0.655	.	5.380	4.290	2.526	1.138	0.665	0.964	0.752	0.917	303	.	.	.	.	RPGRIP1L	274	0	116	17	0.12781954887218	TRUE	TRUE
ENSG00000157423.18	.	BCM	GRCh38.p13	chr16	71020226	71020226	+	C	C	A	Missense_Mutation	SNP	ENST00000393567.7	exon22	c.G3278T	p.G1093V	exonic	ENSG00000157423.18	.	nonsynonymous SNV	ENSG00000157423.18:ENST00000393567.7:exon22:c.G3278T:p.G1093V	16q22.2	C3N-03754	.	.	.	.	.	.	.	.	.	0.16	T	.	.	.	U	N	L	T	N	0.239	T	T	T	0.065	0.415	0.113	.	T	T	T	T	T	.	0.310	4.408	0.771	N	N	-0.799	0.656	-0.934	0.574	1.000	0.534	0.586	0.686	0.542	.	4.610	-2.310	0.010	0.130	-0.187	0.000	0.361	0.904	610	.	.	.	ID=COSV66833525;OCCURENCE=1(lung)	HYDIN	157	0	132	12	0.0833333333333333	NA	TRUE
ENSG00000167840.13	.	BCM	GRCh38.p13	chr17	5105858	5105858	+	C	C	T	Missense_Mutation	SNP	ENST00000250076.7	exon5	c.G1301A	p.R434Q	exonic	ENSG00000167840.13	.	nonsynonymous SNV	ENSG00000167840.13:ENST00000250076.7:exon5:c.G1301A:p.R434Q	17p13.2	C3N-03754	2.596e-05	0	0	0	0	4.613e-05	0	0	rs200981387	0.17	T	T	.	.	N	N	.	T	N	0.066	T	T	T	0.036	.	0.040	0.039	T	T	T	T	T	T	0.842	9.816	0.186	N	N	-1.664	0.042	-1.580	0.081	0.008	0.732	0.744	0.702	0.655	.	2.980	0.461	-0.236	-0.190	-0.313	0.000	0.128	0.425	599	Zinc_finger_C2H2-type	.	.	ID=COSV51503834;OCCURENCE=1(soft_tissue),1(upper_aerodigestive_tract)	ZNF232	79	0	24	4	0.142857142857143	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675095	7675095	+	C	C	A	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G517T	p.V173L	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G517T:p.V173L	17p13.1	C3N-03754	.	.	.	.	.	.	.	.	rs876660754	18.20	D	D	D	D	D	D	M	D	D	0.899	D	D	D	0.880	0.885	0.976	1.647	T	D	D	D	D	T	3.328	24.200	0.997	D	D	0.766	8.144	0.634	6.672	1.000	0.722	0.698	0.698	0.735	.	5.590	5.590	7.905	1.026	0.599	1.000	0.746	0.500	434	p53,_DNA-binding_domain	.	.	ID=COSV52676535;OCCURENCE=8(breast),1(liver),14(oesophagus),19(large_intestine),6(central_nervous_system),4(ovary),4(vulva),1(bone),1(NS),5(haematopoietic_and_lymphoid_tissue),10(stomach),1(urinary_tract),1(soft_tissue),3(kidney),2(pancreas),1(prostate),16(lung),11(upper_aerodigestive_tract),1(small_intestine)	TP53	442	0	263	102	0.279452054794521	TRUE	TRUE
ENSG00000274808.5	.	BCM	GRCh38.p13	chr17	36168103	36168103	+	T	T	C	Missense_Mutation	SNP	ENST00000611257.4	exon12	c.A892G	p.M298V	exonic	ENSG00000274808.5	.	nonsynonymous SNV	ENSG00000274808.5:ENST00000611257.4:exon12:c.A892G:p.M298V	17q12	C3N-03754	.	.	.	.	.	.	.	.	.	1.17	.	T	B	B	U	N	L	.	.	0.222	T	T	T	0.037	0.647	0.043	.	T	T	T	T	T	D	1.193	13.580	0.530	N	N	-0.795	0.661	-0.926	0.585	0.000	0.693	0.659	0.653	0.621	.	.	.	0.988	0.272	0.236	0.960	0.017	0.018	882	Rab-GTPase-TBC_domain	.	.	.	TBC1D3B	157	0	144	16	0.1	NA	TRUE
ENSG00000080573.7	.	BCM	GRCh38.p13	chr19	9960508	9960508	+	G	G	A	Missense_Mutation	SNP	ENST00000264828.4	exon67	c.C5141T	p.A1714V	exonic	ENSG00000080573.7	.	nonsynonymous SNV	ENSG00000080573.7:ENST00000264828.4:exon67:c.C5141T:p.A1714V	19p13.2	C3N-03754	2.473e-05	0	0	0	0	4.499e-05	0	0	rs199939192	0.20	T	T	B	B	N	N	N	T	N	0.033	T	T	T	0.062	.	0.297	0.347	T	T	T	T	T	T	0.311	4.416	0.362	N	N	-1.623	0.050	-1.532	0.096	0.034	0.615	0.588	0.659	0.542	.	4.030	-0.960	0.252	-0.079	-0.651	0.000	0.551	0.303	909	Fibrillar_collagen,_C-terminal	.	.	.	COL5A3	294	0	232	58	0.2	TRUE	NA
ENSG00000090924.15	.	BCM	GRCh38.p13	chr19	39414165	39414165	+	G	G	A	Missense_Mutation	SNP	ENST00000425673.6	exon2	c.G79A	p.D27N	exonic	ENSG00000090924.15	.	nonsynonymous SNV	ENSG00000090924.15:ENST00000425673.6:exon2:c.G79A:p.D27N	19q13.2	C3N-03754	.	.	.	.	.	.	.	.	.	3.19	D	D	B	B	.	N	L	T	N	0.180	T	T	D	0.019	0.350	0.591	.	T	T	T	T	T	T	2.328	21.700	0.996	N	N	-0.508	1.160	-0.387	1.396	1.000	0.789	0.522	0.768	0.562	.	3.760	2.710	0.992	0.222	0.676	0.002	0.823	0.965	683	.	.	.	.	PLEKHG2	210	0	323	18	0.0527859237536657	TRUE	NA
ENSG00000124440.15	.	BCM	GRCh38.p13	chr19	46329333	46329333	+	C	C	T	Missense_Mutation	SNP	ENST00000377670.8	exon12	c.C1567T	p.R523C	exonic	ENSG00000124440.15	.	nonsynonymous SNV	ENSG00000124440.15:ENST00000377670.8:exon12:c.C1567T:p.R523C	19q13.32	C3N-03754	2.547e-05	0	0.0002	0	0	1.556e-05	0	0	rs955256023	9.20	D	T	D	D	N	D	L	T	N	0.726	T	T	D	0.227	.	0.851	0.777	T	T	T	D	T	D	3.866	26.200	0.999	D	D	0.477	4.861	0.483	5.007	0.013	0.707	0.574	0.725	0.492	.	4.820	4.820	3.453	1.026	0.599	0.999	0.946	0.801	473	.	.	.	.	HIF3A	215	0	181	20	0.0995024875621891	TRUE	NA
ENSG00000101180.16	.	BCM	GRCh38.p13	chr20	62216392	62216392	+	G	G	A	Missense_Mutation	SNP	ENST00000340177.10	exon3	c.C952T	p.R318C	exonic	ENSG00000101180.16	.	nonsynonymous SNV	ENSG00000101180.16:ENST00000340177.10:exon3:c.C952T:p.R318C	20q13.33	C3N-03754	0	0	0	0	0	0	0	0	rs201799413	7.20	D	D	B	B	N	N	M	T	N	0.174	T	T	D	0.141	0.410	0.832	1.357	T	T	T	T	D	D	2.977	23.400	0.995	D	N	-0.090	2.208	0.042	2.509	0.578	0.696	0.547	0.723	0.563	.	4.610	3.540	2.381	1.152	0.650	0.960	0.995	0.923	856	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV100420420;OCCURENCE=1(large_intestine)	HRH3	100	0	49	8	0.140350877192982	TRUE	NA
ENSG00000198862.14	.	BCM	GRCh38.p13	chr21	28945848	28945848	+	C	C	T	Missense_Mutation	SNP	ENST00000361371.10	exon21	c.G3727A	p.E1243K	exonic	ENSG00000198862.14	.	nonsynonymous SNV	ENSG00000198862.14:ENST00000361371.10:exon21:c.G3727A:p.E1243K	21q21.3	C3N-03754	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	M	T	N	0.542	T	T	T	0.078	0.363	0.200	0.343	T	T	T	T	D	D	3.521	24.800	0.997	D	N	-0.064	2.292	0.107	2.763	1.000	0.722	0.709	0.609	0.735	.	4.800	4.800	3.161	1.026	0.549	0.997	1.000	0.985	973	.	.	.	.	LTN1	105	0	34	9	0.209302325581395	TRUE	TRUE
ENSG00000101745.17	.	BCM	GRCh38.p13	chr18	9216756	9216756	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000101745.17	ENST00000262126.9:exon7:c.653-2A>G	.	.	18p11.22	C3N-03754	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.494	34	0.995	D	.	1.169	21.244	1.027	20.569	1.000	0.295	0.304	0.175	0.118	0.976	5.680	5.680	9.325	1.311	0.756	1.000	0.998	0.971	380	.	.	.	.	ANKRD12	112	0	32	4	0.111111111111111	NA	TRUE
ENSG00000169432.18	.	BCM	GRCh38.p13	chr2	166242562	166242562	+	A	A	T	Silent	SNP	ENST00000642356.2	exon19	c.T3567A	p.V1189V	exonic	ENSG00000169432.18	.	synonymous SNV	ENSG00000169432.18:ENST00000642356.2:exon19:c.T3567A:p.V1189V	2q24.3	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCN9A	167	0	44	7	0.137254901960784	NA	TRUE
ENSG00000206260.4	.	BCM	GRCh38.p13	chr3	139005801	139005801	+	G	G	A	Silent	SNP	ENST00000383163.4	exon1	c.C468T	p.Y156Y	exonic	ENSG00000206260.4	.	synonymous SNV	ENSG00000206260.4:ENST00000383163.4:exon1:c.C468T:p.Y156Y	3q23	C3N-03754	1.695e-05	0	0	0	0	3.071e-05	0	0	rs749352615	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67214839;OCCURENCE=1(large_intestine),1(urinary_tract),1(lung),1(endometrium)	PRR23A	444	0	474	119	0.200674536256324	NA	TRUE
ENSG00000145244.12	.	BCM	GRCh38.p13	chr4	47806999	47806999	+	G	G	A	Silent	SNP	ENST00000273857.9	exon2	c.C112T	p.L38L	exonic	ENSG00000145244.12	.	synonymous SNV	ENSG00000145244.12:ENST00000273857.9:exon2:c.C112T:p.L38L	4p12	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CORIN	187	0	112	26	0.188405797101449	TRUE	TRUE
ENSG00000083857.14	.	BCM	GRCh38.p13	chr4	186663600	186663600	+	C	C	T	Silent	SNP	ENST00000441802.7	exon3	c.G3279A	p.T1093T	exonic	ENSG00000083857.14	.	synonymous SNV	ENSG00000083857.14:ENST00000441802.7:exon3:c.G3279A:p.T1093T	4q35.2	C3N-03754	5.064e-05	0	0	0.0001	0	4.592e-05	0	0.0001	rs145277827	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAT1	119	0	80	9	0.101123595505618	TRUE	NA
ENSG00000131503.21	.	BCM	GRCh38.p13	chr5	140402015	140402015	+	G	G	T	Silent	SNP	ENST00000360839.7	exon1	c.G48T	p.L16L	exonic	ENSG00000131503.21;ENSG00000254996.5	.	synonymous SNV	ENSG00000131503.21:ENST00000360839.7:exon1:c.G48T:p.L16L,ENSG00000254996.5:ENST00000532219.5:exon1:c.G48T:p.L16L	5q31.3	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANKHD1	81	0	60	11	0.154929577464789	TRUE	TRUE
ENSG00000164756.12	.	BCM	GRCh38.p13	chr8	117157744	117157744	+	C	C	T	Silent	SNP	ENST00000456015.6	exon4	c.C472T	p.L158L	exonic	ENSG00000164756.12	.	synonymous SNV	ENSG00000164756.12:ENST00000456015.6:exon4:c.C472T:p.L158L	8q24.11	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC30A8	199	0	164	27	0.141361256544503	TRUE	TRUE
ENSG00000178814.17	.	BCM	GRCh38.p13	chr8	144053317	144053317	+	C	C	T	Silent	SNP	ENST00000618853.5	exon20	c.G2763A	p.S921S	exonic	ENSG00000178814.17	.	synonymous SNV	ENSG00000178814.17:ENST00000618853.5:exon20:c.G2763A:p.S921S	8q24.3	C3N-03754	2.522e-05	0	0	0	0.0002	0	0	0.0001	rs782103109	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OPLAH	261	0	155	30	0.162162162162162	TRUE	NA
ENSG00000066654.14	.	BCM	GRCh38.p13	chr16	20737826	20737826	+	A	A	G	Silent	SNP	ENST00000396083.7	exon3	c.T537C	p.Y179Y	exonic	ENSG00000066654.14	.	synonymous SNV	ENSG00000066654.14:ENST00000396083.7:exon3:c.T537C:p.Y179Y	16p12.3	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	THUMPD1	263	0	79	18	0.185567010309278	TRUE	TRUE
ENSG00000105426.17	.	BCM	GRCh38.p13	chr19	5244034	5244034	+	G	G	A	Silent	SNP	ENST00000587303.5	exon10	c.C1437T	p.N479N	exonic	ENSG00000105426.17	.	synonymous SNV	ENSG00000105426.17:ENST00000587303.5:exon10:c.C1437T:p.N479N	19p13.3	C3N-03754	.	.	.	.	.	.	.	.	rs1002891578	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53626191;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	PTPRS	233	0	182	42	0.1875	TRUE	TRUE
ENSG00000171105.14	.	BCM	GRCh38.p13	chr19	7267409	7267409	+	G	G	A	Silent	SNP	ENST00000302850.10	exon2	c.C588T	p.C196C	exonic	ENSG00000171105.14	.	synonymous SNV	ENSG00000171105.14:ENST00000302850.10:exon2:c.C588T:p.C196C	19p13.2	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INSR	242	0	147	35	0.192307692307692	TRUE	TRUE
ENSG00000104888.10	.	BCM	GRCh38.p13	chr19	49431033	49431033	+	C	C	T	Silent	SNP	ENST00000221485.8	exon11	c.G1371A	p.G457G	exonic	ENSG00000104888.10	.	synonymous SNV	ENSG00000104888.10:ENST00000221485.8:exon11:c.G1371A:p.G457G	19q13.33	C3N-03754	2.519e-05	0	0	0	0	4.557e-05	0	0	rs776117731	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC17A7	99	0	69	21	0.233333333333333	TRUE	NA
ENSG00000123572.17	.	BCM	GRCh38.p13	chrX	105909867	105909867	+	G	G	A	Silent	SNP	ENST00000243300.14	exon13	c.G2226A	p.L742L	exonic	ENSG00000123572.17	.	synonymous SNV	ENSG00000123572.17:ENST00000243300.14:exon13:c.G2226A:p.L742L	Xq22.3	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NRK	64	0	42	14	0.25	TRUE	TRUE
ENSG00000149091.15	.	BCM	GRCh38.p13	chr11	46366885	46366885	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000149091.15	.	.	.	11p11.2	C3N-03754	.	.	.	.	.	.	.	.	.	4.20	T	D	B	B	N	D	L	T	N	0.151	T	T	D	0.170	0.201	0.598	0.120	T	T	T	T	T	T	0.698	8.433	0.508	D	N	-0.546	1.088	-0.549	1.125	1.000	0.616	0.577	0.618	0.509	.	4.480	4.480	1.084	0.199	-0.153	0.007	0.001	0.003	40	.	.	.	.	DGKZ	347	1	244	45	0.155709342560554	TRUE	NA
ENSG00000246877.1	.	BCM	GRCh38.p13	chr15	75738587	75738587	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000246877.1	.	.	.	15q24.2	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNM1P35	8	1	4	4	0.5	TRUE	NA
ENSG00000124092.12	.	BCM	GRCh38.p13	chr20	57515664	57515664	+	T	T	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000124092.12	.	.	.	20q13.31	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTCFL	167	0	129	28	0.178343949044586	TRUE	NA
ENSG00000111725.11	.	BCM	GRCh38.p13	chr12	119668368	119668370	+	GAA	GAA	CAC	Unknown	MNP	ENST00000229328.10	exon1	c.124_126delinsCAC	p.E42H	exonic	ENSG00000111725.11	.	nonframeshift substitution	ENSG00000111725.11:ENST00000229328.10:exon1:c.124_126delinsCAC:p.E42H	12q24.23	C3N-03754	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRKAB1	391	63	278	63	0.18475073313783	TRUE	TRUE
ENSG00000048707.15	.	BCM	GRCh38.p13	chr1	12456029	12456029	+	A	A	C	Missense_Mutation	SNP	ENST00000620676.6	exon66	c.A12365C	p.K4122T	exonic	ENSG00000048707.15	.	nonsynonymous SNV	ENSG00000048707.15:ENST00000620676.6:exon66:c.A12365C:p.K4122T	1p36.22	C3L-01037	.	.	.	.	.	.	.	.	.	10.17	.	T	B	B	D	D	N	.	.	0.706	T	T	T	0.327	.	0.043	.	D	D	D	D	D	D	2.911	23.200	0.996	D	D	0.285	3.702	0.456	4.779	1.000	0.706	0.654	0.710	0.635	.	6.020	6.020	8.911	1.312	0.756	1.000	1.000	0.997	221	Vacuolar_protein_sorting-associated_protein_13,_C-terminal	.	.	.	VPS13D	143	0	171	24	0.123076923076923	TRUE	TRUE
ENSG00000198691.13	.	BCM	GRCh38.p13	chr1	94030452	94030452	+	C	C	T	Missense_Mutation	SNP	ENST00000370225.4	exon29	c.G4328A	p.R1443H	exonic	ENSG00000198691.13	.	nonsynonymous SNV	ENSG00000198691.13:ENST00000370225.4:exon29:c.G4328A:p.R1443H	1p22.1	C3L-01037	2.472e-05	0	0	0	0	4.498e-05	0	0	rs61750142	17.20	D	T	D	D	N	D	M	D	D	0.716	D	D	D	0.805	.	0.973	0.476	T	D	D	D	D	D	3.729	25.500	1.000	D	D	0.516	5.159	0.442	4.667	1.000	0.554	0.547	0.600	0.568	.	4.650	3.720	3.432	0.103	0.599	1.000	0.997	0.994	549	.	.	.	ID=COSV64673800;OCCURENCE=1(liver)	ABCA4	550	0	677	65	0.0876010781671159	TRUE	TRUE
ENSG00000151694.14	.	BCM	GRCh38.p13	chr2	9535901	9535901	+	A	A	T	Missense_Mutation	SNP	ENST00000310823.8	exon4	c.T383A	p.L128Q	exonic	ENSG00000151694.14	.	nonsynonymous SNV	ENSG00000151694.14:ENST00000310823.8:exon4:c.T383A:p.L128Q	2p25.1	C3L-01037	.	.	.	.	.	.	.	.	.	6.20	T	D	B	B	D	D	N	T	N	0.537	T	T	T	0.176	0.545	0.613	0.416	T	T	T	T	D	D	2.107	20.200	0.980	D	N	0.216	3.374	0.321	3.843	1.000	0.732	0.744	0.710	0.613	.	5.330	5.330	4.689	1.312	0.756	1.000	1.000	0.999	606	Peptidase_M12B,_propeptide	.	.	.	ADAM17	222	0	265	31	0.10472972972973	TRUE	TRUE
ENSG00000183091.19	.	BCM	GRCh38.p13	chr2	151655912	151655912	+	T	T	C	Missense_Mutation	SNP	ENST00000172853.14	exon50	c.A6607G	p.K2203E	exonic	ENSG00000183091.19	.	nonsynonymous SNV	ENSG00000183091.19:ENST00000172853.14:exon50:c.A6607G:p.K2203E	2q23.3	C3L-01037	.	.	.	.	.	.	.	.	.	6.20	T	D	B	B	N	N	M	T	N	0.564	T	T	T	0.069	0.326	0.411	0.176	T	T	T	T	D	D	3.260	24.000	0.996	D	D	-0.181	1.931	-0.076	2.116	1.000	0.554	0.574	0.618	0.479	.	5.300	5.300	1.962	1.138	0.665	0.745	1.000	0.995	904	.	.	.	.	NEB	306	1	387	32	0.0763723150357995	TRUE	TRUE
ENSG00000081479.15	.	BCM	GRCh38.p13	chr2	169272980	169272980	+	C	C	T	Missense_Mutation	SNP	ENST00000649046.1	exon15	c.G2063A	p.R688H	exonic	ENSG00000081479.15	.	nonsynonymous SNV	ENSG00000081479.15:ENST00000649046.1:exon15:c.G2063A:p.R688H	2q31.1	C3L-01037	6.595e-05	0	0	0	0	0.0001	0.0011	0	rs148943767	17.20	D	D	D	D	D	D	L	D	D	0.875	D	D	D	0.721	.	0.770	0.976	T	T	D	D	D	D	4.048	27.300	0.999	D	D	0.776	8.336	0.754	8.885	1.000	0.361	0.563	0.567	0.530	.	5.500	5.500	7.792	1.026	0.599	1.000	0.897	0.917	892	EGF-like_domain	.	.	ID=COSV55571441;OCCURENCE=1(large_intestine)	LRP2	534	0	609	34	0.0528771384136858	TRUE	NA
ENSG00000162992.3	.	BCM	GRCh38.p13	chr2	181678577	181678577	+	C	C	T	Missense_Mutation	SNP	ENST00000295108.3	exon2	c.G284A	p.R95H	exonic	ENSG00000162992.3	.	nonsynonymous SNV	ENSG00000162992.3:ENST00000295108.3:exon2:c.G284A:p.R95H	2q31.3	C3L-01037	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.521	D	D	D	0.648	0.257	0.995	1.462	T	D	D	D	D	D	4.176	28.400	1.000	N	D	0.888	10.738	0.881	12.959	1.000	0.598	0.563	0.616	0.639	.	6.160	6.160	6.059	1.026	0.599	1.000	1.000	0.998	854	.	.	.	ID=COSV54548947;OCCURENCE=1(large_intestine),1(lung)	NEUROD1	458	0	695	70	0.0915032679738562	TRUE	TRUE
ENSG00000010322.16	.	BCM	GRCh38.p13	chr3	52488134	52488134	+	G	G	A	Nonsense_Mutation	SNP	ENST00000345716.9	exon16	c.G2642A	p.W881X	exonic	ENSG00000010322.16	.	stopgain	ENSG00000010322.16:ENST00000345716.9:exon16:c.G2642A:p.W881X	3p21.1	C3L-01037	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.812	.	.	.	.	.	.	.	.	.	D	D	.	.	7.693	39	0.994	D	N	0.802	8.814	0.668	7.197	0.997	0.707	0.702	0.702	0.714	.	5.040	5.040	3.156	1.172	0.672	1.000	1.000	0.987	75	.	.	.	.	NISCH	391	0	556	55	0.0900163666121113	TRUE	TRUE
ENSG00000114124.2	.	BCM	GRCh38.p13	chr3	141780636	141780636	+	G	G	A	Missense_Mutation	SNP	ENST00000264952.2	exon2	c.G875A	p.R292Q	exonic	ENSG00000114124.2	.	nonsynonymous SNV	ENSG00000114124.2:ENST00000264952.2:exon2:c.G875A:p.R292Q	3q23	C3L-01037	0.0001	0.0009	0.0002	0	0	1.499e-05	0	6.058e-05	rs146685701	12.20	D	D	D	D	D	D	L	T	D	0.694	T	T	D	0.568	.	0.931	0.746	T	T	T	D	T	D	3.812	25.900	0.999	D	D	0.484	4.914	0.460	4.812	1.000	0.487	0.574	0.547	0.530	.	5.100	5.100	7.759	1.006	0.676	1.000	0.585	0.931	721	Protein_kinase_domain	.	.	.	GRK7	361	0	450	49	0.0981963927855711	TRUE	NA
ENSG00000196549.11	.	BCM	GRCh38.p13	chr3	155147172	155147172	+	A	A	G	Missense_Mutation	SNP	ENST00000360490.7	exon15	c.A1445G	p.Y482C	exonic	ENSG00000196549.11	.	nonsynonymous SNV	ENSG00000196549.11:ENST00000360490.7:exon15:c.A1445G:p.Y482C	3q25.2	C3L-01037	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.978	D	D	D	0.925	0.901	0.970	0.432	T	D	D	D	D	D	4.220	28.800	0.999	D	D	0.847	9.775	0.823	10.846	1.000	0.693	0.574	0.653	0.564	.	5.840	5.840	7.397	1.312	0.756	1.000	1.000	0.998	778	Peptidase_M13,_N-terminal_domain	.	.	.	MME	248	0	291	28	0.0877742946708464	TRUE	TRUE
ENSG00000152592.14	.	BCM	GRCh38.p13	chr4	87656505	87656505	+	A	A	T	Missense_Mutation	SNP	ENST00000339673.11	exon2	c.A13T	p.I5F	exonic	ENSG00000152592.14	.	nonsynonymous SNV	ENSG00000152592.14:ENST00000339673.11:exon2:c.A13T:p.I5F	4q22.1	C3L-01037	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.357	T	T	T	0.106	0.710	0.389	0.375	T	T	T	T	T	T	0.564	7.157	0.962	N	N	-1.052	0.351	-1.038	0.443	0.998	0.554	0.574	0.618	0.613	.	5.620	-3.620	-0.428	0.323	-0.065	0.001	0.934	0.859	421	.	.	.	.	DMP1	434	0	530	41	0.0718038528896672	TRUE	TRUE
ENSG00000173376.14	.	BCM	GRCh38.p13	chr4	121036368	121036368	+	G	G	T	Missense_Mutation	SNP	ENST00000379692.9	exon4	c.C1603A	p.L535I	exonic	ENSG00000173376.14	.	nonsynonymous SNV	ENSG00000173376.14:ENST00000379692.9:exon4:c.C1603A:p.L535I	4q27	C3L-01037	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	N	0.699	T	D	T	0.533	0.810	0.884	0.547	T	T	D	D	D	D	3.903	26.400	0.995	D	D	0.888	10.746	0.874	12.685	1.000	0.554	0.574	0.618	0.564	.	6.030	6.030	8.136	1.155	0.676	1.000	0.997	0.999	826	Fibronectin_type_III	.	.	.	NDNF	305	0	356	26	0.0680628272251309	TRUE	TRUE
ENSG00000164306.11	.	BCM	GRCh38.p13	chr4	184685642	184685642	+	G	G	A	Nonsense_Mutation	SNP	ENST00000314970.11	exon11	c.G1253A	p.W418X	exonic	ENSG00000164306.11	.	stopgain	ENSG00000164306.11:ENST00000314970.11:exon11:c.G1253A:p.W418X	4q35.1	C3L-01037	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.463	.	.	.	.	.	.	.	.	.	D	D	.	.	9.026	47	0.997	D	N	1.035	15.067	0.941	15.625	1.000	0.615	0.634	0.659	0.655	.	5.920	5.920	8.997	1.156	0.670	1.000	1.000	0.996	915	.	.	.	.	PRIMPOL	136	0	185	16	0.0796019900497512	TRUE	TRUE
ENSG00000145863.11	.	BCM	GRCh38.p13	chr5	161686334	161686334	+	G	G	A	Missense_Mutation	SNP	ENST00000274545.10	exon2	c.G143A	p.R48Q	exonic	ENSG00000145863.11	.	nonsynonymous SNV	ENSG00000145863.11:ENST00000274545.10:exon2:c.G143A:p.R48Q	5q34	C3L-01037	1.648e-05	0	0	0	0	1.499e-05	0	6.057e-05	rs751098162	19.20	D	D	D	D	D	D	H	D	D	0.934	D	D	D	0.864	0.946	0.986	0.442	T	D	D	D	D	D	4.249	29.100	0.999	D	D	1.018	14.507	0.913	14.318	1.000	0.487	0.574	0.574	0.564	.	5.630	5.630	9.407	1.176	0.676	1.000	0.955	0.748	923	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	ID=COSV50883531;OCCURENCE=1(breast),1(liver),1(large_intestine)	GABRA6	605	1	693	66	0.0869565217391304	TRUE	TRUE
ENSG00000072803.17	.	BCM	GRCh38.p13	chr5	171891549	171891549	+	C	C	T	Missense_Mutation	SNP	ENST00000265094.9	exon6	c.G707A	p.R236H	exonic	ENSG00000072803.17	.	nonsynonymous SNV	ENSG00000072803.17:ENST00000265094.9:exon6:c.G707A:p.R236H	5q35.1	C3L-01037	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	D	D	N	T	N	0.619	T	T	T	0.169	.	0.589	1.630	D	T	T	T	D	D	2.631	22.700	0.968	D	D	0.001	2.515	0.214	3.253	1.000	0.732	0.744	0.725	0.728	.	4.960	4.960	7.797	0.947	0.549	1.000	0.999	0.997	946	WD40-repeat-containing_domain	.	.	ID=COSV51613076;OCCURENCE=1(urinary_tract),1(endometrium)	FBXW11	215	0	280	19	0.0635451505016722	NA	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152321362	152321362	+	C	C	T	Missense_Mutation	SNP	ENST00000367255.10	exon84	c.G16112A	p.R5371Q	exonic	ENSG00000131018.24	.	nonsynonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon84:c.G16112A:p.R5371Q	6q25.2	C3L-01037	1.659e-05	0	0	0.0001	0	0	0	6.105e-05	rs527462104	5.20	T	D	B	B	N	D	L	T	N	0.211	T	T	T	0.026	0.381	0.457	0.155	T	T	T	T	T	D	2.215	21.000	0.940	D	D	-0.204	1.865	-0.084	2.093	0.826	0.554	0.590	0.574	0.568	.	5.250	1.970	2.976	0.138	0.599	0.996	0.995	0.997	835	.	.	.	ID=COSV55034205;OCCURENCE=1(large_intestine),1(stomach)	SYNE1	194	0	239	18	0.0700389105058366	TRUE	TRUE
ENSG00000204947.9	.	BCM	GRCh38.p13	chr7	149105168	149105168	+	G	G	A	Missense_Mutation	SNP	ENST00000378061.7	exon4	c.C703T	p.R235W	exonic	ENSG00000204947.9	.	nonsynonymous SNV	ENSG00000204947.9:ENST00000378061.7:exon4:c.C703T:p.R235W	7q36.1	C3L-01037	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	L	T	N	0.114	T	T	T	0.024	0.416	0.289	0.313	T	T	T	T	T	T	-0.254	0.391	0.831	N	N	-1.413	0.112	-1.458	0.125	0.000	0.651	0.588	0.651	0.613	.	2.620	-2.900	-4.848	-0.780	-0.633	0.000	0.001	0.050	958	.	.	.	ID=COSV100955618;OCCURENCE=1(endometrium)	ZNF425	316	0	426	39	0.0838709677419355	TRUE	TRUE
ENSG00000175946.8	.	BCM	GRCh38.p13	chr8	123645908	123645908	+	G	G	A	Missense_Mutation	SNP	ENST00000325995.7	exon3	c.C1577T	p.T526M	exonic	ENSG00000175946.8	.	nonsynonymous SNV	ENSG00000175946.8:ENST00000325995.7:exon3:c.C1577T:p.T526M	8q24.13	C3L-01037	4.968e-05	0.0004	0	0	0	0	0	0.0001	rs373548260	15.20	D	D	D	D	D	D	L	T	D	0.740	D	D	D	0.610	.	0.828	0.291	T	T	T	D	D	D	4.207	28.700	0.999	D	D	0.707	7.224	0.697	7.688	1.000	0.447	0.563	0.547	0.530	.	5.000	5.000	10.003	1.176	0.676	1.000	0.758	0.642	969	.	.	.	ID=COSV58086469;OCCURENCE=1(parathyroid),3(pancreas)	KLHL38	592	0	890	196	0.180478821362799	TRUE	TRUE
ENSG00000044459.15	.	BCM	GRCh38.p13	chr9	17143307	17143307	+	G	G	T	Missense_Mutation	SNP	ENST00000380647.8	exon2	c.G380T	p.W127L	exonic	ENSG00000044459.15	.	nonsynonymous SNV	ENSG00000044459.15:ENST00000380647.8:exon2:c.G380T:p.W127L	9p22.2	C3L-01037	.	.	.	.	.	.	.	.	.	12.18	D	D	D	D	.	D	M	T	D	0.915	T	T	T	0.411	0.490	0.199	.	T	.	D	D	D	T	4.416	31	0.986	D	D	0.891	10.826	0.907	14.036	1.000	0.693	0.588	0.659	0.655	.	6.070	6.070	7.379	1.176	0.676	1.000	1.000	0.999	719	.	.	.	.	CNTLN	183	0	201	29	0.126086956521739	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971109	21971109	+	C	C	T	Missense_Mutation	SNP	ENST00000304494.9	exon2	c.G250A	p.D84N	exonic	ENSG00000147889.17	.	nonsynonymous SNV	ENSG00000147889.17:ENST00000304494.9:exon2:c.G250A:p.D84N	9p21.3	C3L-01037	.	.	.	.	.	.	.	.	rs11552822	17.18	D	D	D	D	.	D	.	D	D	0.785	D	D	D	0.670	0.399	0.971	1.197	T	D	D	D	D	D	4.519	32	0.999	D	D	0.737	7.663	0.775	9.433	1.000	0.677	0.383	0.607	0.601	.	5.930	5.930	7.307	1.026	0.599	1.000	0.984	0.972	900	Ankyrin_repeat-containing_domain	.	.	ID=COSV58683289;OCCURENCE=1(penis),3(oesophagus),1(central_nervous_system),4(biliary_tract),1(ovary),3(urinary_tract),2(pancreas),4(skin),8(lung),2(upper_aerodigestive_tract)	CDKN2A	736	0	706	112	0.136919315403423	TRUE	TRUE
ENSG00000119487.17	.	BCM	GRCh38.p13	chr9	125672331	125672331	+	T	T	C	Missense_Mutation	SNP	ENST00000265960.8	exon2	c.A244G	p.R82G	exonic	ENSG00000119487.17	.	nonsynonymous SNV	ENSG00000119487.17:ENST00000265960.8:exon2:c.A244G:p.R82G	9q33.3	C3L-01037	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	M	.	D	0.789	T	T	T	0.434	0.640	0.532	1.692	D	D	D	D	D	D	4.131	28.000	0.999	D	D	0.634	6.288	0.630	6.615	1.000	0.737	0.725	0.733	0.714	.	5.800	5.800	3.141	1.138	0.665	1.000	1.000	1.000	94	Sin1,_N-terminal	.	.	.	MAPKAP1	188	0	231	21	0.0833333333333333	TRUE	TRUE
ENSG00000170835.16	.	BCM	GRCh38.p13	chr9	133071495	133071495	+	T	T	G	Missense_Mutation	SNP	ENST00000372080.8	exon11	c.T1993G	p.S665A	exonic	ENSG00000170835.16	.	nonsynonymous SNV	ENSG00000170835.16:ENST00000372080.8:exon11:c.T1993G:p.S665A	9q34.13	C3L-01037	.	.	.	.	.	.	.	.	rs2480922	3.16	T	D	.	.	.	N	.	T	N	0.165	T	T	D	0.140	.	0.655	0.430	T	T	T	T	T	D	1.307	14.440	0.968	N	N	-0.665	0.872	-0.963	0.536	0.169	0.403	0.547	0.578	0.563	.	1.190	-1.940	-0.029	0.509	0.225	0.000	0.014	0.008	962	Mucin-like_domain	.	.	ID=COSV60827533;OCCURENCE=1(pancreas)	CEL	96	0	87	6	0.0645161290322581	TRUE	NA
ENSG00000196642.19	.	BCM	GRCh38.p13	chr9	136829394	136829394	+	C	C	T	Missense_Mutation	SNP	ENST00000311502.12	exon5	c.C368T	p.A123V	exonic	ENSG00000196642.19	.	nonsynonymous SNV	ENSG00000196642.19:ENST00000311502.12:exon5:c.C368T:p.A123V	9q34.3	C3L-01037	0	0	0	0	0	0	0	0	rs774650717	3.20	T	T	B	B	N	D	L	T	N	0.182	T	T	D	0.051	.	0.462	0.918	T	T	T	T	T	T	1.592	16.320	0.987	D	N	-0.528	1.122	-0.476	1.242	0.987	0.713	0.702	0.636	0.714	.	4.830	2.010	2.928	-0.238	-0.182	0.998	0.794	0.579	976	.	.	.	.	RABL6	201	0	250	29	0.103942652329749	TRUE	NA
ENSG00000204176.14	.	BCM	GRCh38.p13	chr10	46582123	46582123	+	C	C	T	Missense_Mutation	SNP	ENST00000374321.9	exon4	c.C583T	p.R195C	exonic	ENSG00000204176.14	.	nonsynonymous SNV	ENSG00000204176.14:ENST00000374321.9:exon4:c.C583T:p.R195C	10q11.22	C3L-01037	.	.	.	.	.	.	.	.	.	4.7	D	D	.	.	.	.	.	T	D	0.301	.	.	.	.	.	.	.	.	T	.	.	.	D	1.769	17.510	.	.	N	.	.	.	.	.	.	.	.	.	.	.	.	-0.203	1.019	0.578	0.521	0.966	0.995	970	C2_domain	.	.	ID=COSV65430105;OCCURENCE=1(oesophagus),1(large_intestine),1(urinary_tract)	SYT15	87	0	84	10	0.106382978723404	NA	TRUE
ENSG00000165923.16	.	BCM	GRCh38.p13	chr11	47699490	47699490	+	A	A	G	Missense_Mutation	SNP	ENST00000525123.6	exon8	c.T650C	p.I217T	exonic	ENSG00000165923.16	.	nonsynonymous SNV	ENSG00000165923.16:ENST00000525123.6:exon8:c.T650C:p.I217T	11p11.2	C3L-01037	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	N	N	M	T	N	0.131	T	T	T	0.107	0.403	0.540	0.145	T	T	T	T	D	.	2.116	20.200	0.963	D	N	-0.062	2.297	0.090	2.695	0.042	0.554	0.588	0.602	0.564	.	5.220	5.220	3.185	1.280	0.745	1.000	1.000	0.998	11	.	.	.	.	AGBL2	209	0	305	26	0.0785498489425982	TRUE	TRUE
ENSG00000177103.15	.	BCM	GRCh38.p13	chr11	117433443	117433443	+	T	T	C	Missense_Mutation	SNP	ENST00000651296.2	exon28	c.A4905G	p.I1635M	exonic	ENSG00000177103.15	.	nonsynonymous SNV	ENSG00000177103.15:ENST00000651296.2:exon28:c.A4905G:p.I1635M	11q23.3	C3L-01037	.	.	.	.	.	.	.	.	.	5.15	T	T	.	.	.	D	.	T	N	0.362	T	T	D	0.247	.	0.925	1.470	D	.	T	T	T	T	2.753	22.900	0.351	D	D	-0.320	1.566	-0.151	1.909	0.839	0.497	0.492	0.578	0.542	.	4.260	4.260	0.932	1.138	0.609	1.000	0.997	0.951	854	.	.	.	.	DSCAML1	80	0	181	13	0.0670103092783505	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01037	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	310	0	350	77	0.180327868852459	TRUE	TRUE
ENSG00000139220.16	.	BCM	GRCh38.p13	chr12	81344671	81344671	+	C	C	T	Missense_Mutation	SNP	ENST00000549396.5	exon19	c.G2255A	p.R752Q	exonic	ENSG00000139220.16	.	nonsynonymous SNV	ENSG00000139220.16:ENST00000549396.5:exon19:c.G2255A:p.R752Q	12q21.31	C3L-01037	.	.	.	.	.	.	.	.	.	9.20	T	T	D	P	D	D	M	T	N	0.652	T	T	T	0.195	0.319	0.425	0.848	D	T	T	T	D	D	4.422	31	0.999	D	D	0.721	7.428	0.744	8.661	1.000	0.487	0.574	0.574	0.564	.	5.760	5.760	7.386	1.026	0.599	1.000	1.000	1.000	814	.	.	.	ID=COSV61036725;OCCURENCE=1(small_intestine)	PPFIA2	118	0	130	11	0.0780141843971631	TRUE	TRUE
ENSG00000122970.16	.	BCM	GRCh38.p13	chr12	110127499	110127499	+	A	A	-	Frame_Shift_Del	DEL	ENST00000242591.10	exon2	c.119delA	p.D40Vfs*27	exonic	ENSG00000122970.16	.	frameshift deletion	ENSG00000122970.16:ENST00000242591.10:exon2:c.119delA:p.D40Vfs*27	12q24.11	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IFT81	126	0	147	16	0.098159509202454	TRUE	TRUE
ENSG00000181234.9	.	BCM	GRCh38.p13	chr12	128414864	128414864	+	G	G	A	Missense_Mutation	SNP	ENST00000435159.2	exon2	c.G218A	p.R73Q	exonic	ENSG00000181234.9	.	nonsynonymous SNV	ENSG00000181234.9:ENST00000435159.2:exon2:c.G218A:p.R73Q	12q24.32	C3L-01037	5.088e-05	0	0	0	0	0	0	0.0001	rs545431831	5.17	T	T	.	.	.	D	M	T	N	0.450	T	T	T	0.106	0.241	0.093	0.234	T	T	T	T	T	D	3.398	24.400	0.999	D	D	0.016	2.570	-0.096	2.058	0.009	0.554	0.574	0.618	0.564	.	4.290	3.390	5.411	1.176	0.676	1.000	0.592	0.273	994	Transmembrane_protein_TMEM132,_N-terminal	.	.	.	TMEM132C	244	0	374	48	0.113744075829384	TRUE	NA
ENSG00000100813.14	.	BCM	GRCh38.p13	chr14	23080556	23080556	+	T	T	C	Missense_Mutation	SNP	ENST00000262710.5	exon6	c.A953G	p.E318G	exonic	ENSG00000100813.14	.	nonsynonymous SNV	ENSG00000100813.14:ENST00000262710.5:exon6:c.A953G:p.E318G	14q11.2	C3L-01037	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.135	T	T	T	0.020	0.131	0.194	0.033	T	T	T	T	T	T	1.896	18.460	0.988	D	N	-0.525	1.128	-0.412	1.351	1.000	0.722	0.725	0.702	0.735	.	4.760	3.600	1.990	1.138	0.665	0.907	0.929	0.863	808	.	.	.	.	ACIN1	342	0	475	72	0.131627056672761	TRUE	TRUE
ENSG00000087302.9	.	BCM	GRCh38.p13	chr14	52004439	52004439	+	A	A	G	Missense_Mutation	SNP	ENST00000261700.8	exon8	c.A658G	p.N220D	exonic	ENSG00000087302.9	.	nonsynonymous SNV	ENSG00000087302.9:ENST00000261700.8:exon8:c.A658G:p.N220D	14q22.1	C3L-01037	.	.	.	.	.	.	.	.	.	11.17	D	D	D	P	D	D	.	.	D	0.871	T	T	T	0.556	0.898	0.642	0.258	.	T	D	T	D	D	4.041	27.300	0.997	D	D	0.871	10.337	0.875	12.733	1.000	0.722	0.725	0.702	0.735	.	6.170	6.170	9.092	1.312	0.750	1.000	0.994	0.991	899	.	.	.	.	RTRAF	180	0	284	22	0.0718954248366013	TRUE	TRUE
ENSG00000183379.9	.	BCM	GRCh38.p13	chr14	74409603	74409603	+	G	G	T	Missense_Mutation	SNP	ENST00000331628.8	exon2	c.C142A	p.P48T	exonic	ENSG00000183379.9	.	nonsynonymous SNV	ENSG00000183379.9:ENST00000331628.8:exon2:c.C142A:p.P48T	14q24.3	C3L-01037	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	L	D	N	0.098	T	D	D	0.140	0.300	0.346	0.361	T	T	T	T	T	T	0.726	8.689	0.367	N	N	-0.928	0.486	-0.940	0.566	1.000	0.657	0.588	0.673	0.542	.	4.440	2.540	0.856	0.219	0.614	0.412	0.003	0.003	257	.	.	.	.	SYNDIG1L	42	0	49	5	0.0925925925925926	TRUE	TRUE
ENSG00000277865.4	.	BCM	GRCh38.p13	chr15	22466233	22466235	+	AGG	AGG	-	In_Frame_Del	DEL	ENST00000622895.1	exon8	c.1841_1843del	p.E616del	exonic	ENSG00000277865.4	.	nonframeshift deletion	ENSG00000277865.4:ENST00000622895.1:exon8:c.1841_1843del:p.E616del	15q11.2	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GOLGA6L22	95	0	80	15	0.157894736842105	NA	TRUE
ENSG00000196557.13	.	BCM	GRCh38.p13	chr16	1220141	1220141	+	G	G	A	Missense_Mutation	SNP	ENST00000348261.11	exon35	c.G6209A	p.R2070H	exonic	ENSG00000196557.13	.	nonsynonymous SNV	ENSG00000196557.13:ENST00000348261.11:exon35:c.G6209A:p.R2070H	16p13.3	C3L-01037	1.407e-05	0	0	0	0	2.302e-05	0	0	rs777897759	6.20	T	T	B	B	N	N	M	D	N	0.234	D	D	D	0.265	0.248	0.889	.	T	T	T	T	D	T	1.698	17.010	0.989	N	N	-0.773	0.694	-0.829	0.717	0.206	0.696	0.547	0.723	0.563	.	4.620	2.650	0.520	1.083	0.618	0.001	0.012	0.005	929	.	.	.	ID=COSV52353458;OCCURENCE=1(large_intestine)	CACNA1H	23	0	34	8	0.19047619047619	TRUE	TRUE
ENSG00000182601.7	.	BCM	GRCh38.p13	chr16	25692455	25692455	+	C	C	T	Missense_Mutation	SNP	ENST00000331351.6	exon1	c.C38T	p.P13L	exonic	ENSG00000182601.7	.	nonsynonymous SNV	ENSG00000182601.7:ENST00000331351.6:exon1:c.C38T:p.P13L	16p12.1	C3L-01037	.	.	.	.	.	.	.	.	rs922018317	5.20	D	D	B	B	U	D	N	T	N	0.296	T	T	D	0.131	0.228	0.251	1.623	D	T	T	T	T	T	2.166	20.600	0.975	N	N	-0.739	0.747	-0.694	0.908	0.081	0.455	0.590	0.607	0.563	.	1.320	1.320	0.479	0.896	0.414	0.000	0.998	0.862	949	.	.	.	.	HS3ST4	97	0	114	7	0.0578512396694215	TRUE	NA
ENSG00000159625.15	.	BCM	GRCh38.p13	chr16	57731239	57731239	+	T	T	A	Missense_Mutation	SNP	ENST00000360716.8	exon19	c.T2606A	p.L869H	exonic	ENSG00000159625.15	.	nonsynonymous SNV	ENSG00000159625.15:ENST00000360716.8:exon19:c.T2606A:p.L869H	16q21	C3L-01037	.	.	.	.	.	.	.	.	.	2.19	D	D	P	B	N	N	.	T	N	0.234	T	T	T	0.129	0.372	0.110	0.226	T	T	T	T	T	T	1.402	15.090	0.745	N	N	-0.676	0.854	-0.827	0.721	0.451	0.578	0.547	0.608	0.542	.	5.280	-0.327	1.597	0.173	-0.174	0.133	0.002	0.007	856	.	.	.	.	DRC7	198	0	283	21	0.0690789473684211	TRUE	TRUE
ENSG00000157423.18	.	BCM	GRCh38.p13	chr16	70970543	70970543	+	G	G	A	Nonsense_Mutation	SNP	ENST00000393567.7	exon36	c.C5596T	p.Q1866X	exonic	ENSG00000157423.18	.	stopgain	ENSG00000157423.18:ENST00000393567.7:exon36:c.C5596T:p.Q1866X	16q22.2	C3L-01037	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	U	A	.	.	.	0.393	.	.	.	.	.	.	.	.	.	D	D	.	.	7.257	37	0.998	D	N	0.814	9.059	0.665	7.144	1.000	0.554	0.563	0.602	0.542	.	4.650	4.650	3.911	1.176	0.676	1.000	0.997	0.982	600	.	.	.	.	HYDIN	69	0	76	11	0.126436781609195	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675143	7675143	+	C	C	A	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G469T	p.V157F	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G469T:p.V157F	17p13.1	C3L-01037	.	.	.	.	.	.	.	.	rs121912654	16.20	D	D	D	D	N	D	M	D	D	0.797	D	D	D	0.708	0.718	0.977	1.914	T	D	D	D	D	D	2.433	22.200	0.991	N	N	-0.151	2.018	-0.381	1.406	0.740	0.722	0.698	0.698	0.735	.	5.470	2.420	0.371	0.114	-0.313	0.050	0.034	0.076	434	p53,_DNA-binding_domain	.	.	ID=COSV52667015;OCCURENCE=19(breast),33(liver),21(oesophagus),1(adrenal_gland),22(large_intestine),9(central_nervous_system),3(biliary_tract),2(vulva),13(ovary),1(bone),1(NS),4(stomach),15(haematopoietic_and_lymphoid_tissue),2(kidney),4(urinary_tract),3(soft_tissue),5(pancreas),3(skin),2(prostate),101(lung),1(thyroid),37(upper_aerodigestive_tract),1(thymus),2(endometrium)	TP53	287	1	343	46	0.118251928020566	TRUE	TRUE
ENSG00000153930.12	.	BCM	GRCh38.p13	chr17	56350791	56350791	+	C	C	A	Missense_Mutation	SNP	ENST00000318698.6	exon4	c.C223A	p.Q75K	exonic	ENSG00000153930.12	.	nonsynonymous SNV	ENSG00000153930.12:ENST00000318698.6:exon4:c.C223A:p.Q75K	17q22	C3L-01037	.	.	.	.	.	.	.	.	.	8.20	D	D	B	B	D	D	L	T	N	0.723	T	T	T	0.109	0.214	0.717	0.625	T	T	T	T	D	D	2.629	22.700	0.996	D	D	0.106	2.911	0.231	3.338	0.986	0.487	0.574	0.574	0.634	.	5.570	4.580	5.835	1.026	0.599	1.000	1.000	0.996	385	.	.	.	.	ANKFN1	289	1	322	38	0.105555555555556	TRUE	NA
ENSG00000089847.12	.	BCM	GRCh38.p13	chr19	4218048	4218048	+	C	C	T	Missense_Mutation	SNP	ENST00000600132.5	exon18	c.C2888T	p.A963V	exonic	ENSG00000089847.12	.	nonsynonymous SNV	ENSG00000089847.12:ENST00000600132.5:exon18:c.C2888T:p.A963V	19p13.3	C3L-01037	0	0	0	0	0	0	0	0	rs754899693	7.19	D	D	D	B	.	N	L	T	N	0.080	T	T	D	0.055	.	0.467	0.754	D	T	T	T	D	T	2.352	21.900	0.999	D	N	0.025	2.600	0.078	2.646	0.023	0.696	0.588	0.723	0.605	.	4.300	4.300	2.792	0.078	0.500	0.983	0.005	0.064	922	.	.	.	.	ANKRD24	320	0	400	48	0.107142857142857	TRUE	NA
ENSG00000101104.13	.	BCM	GRCh38.p13	chr20	44921700	44921700	+	A	A	G	Missense_Mutation	SNP	ENST00000255136.8	exon6	c.A845G	p.Q282R	exonic	ENSG00000101104.13	.	nonsynonymous SNV	ENSG00000101104.13:ENST00000255136.8:exon6:c.A845G:p.Q282R	20q13.12	C3L-01037	1.665e-05	0	0	0	0.0003	0	0	0	rs765113113	10.20	D	D	P	B	D	D	M	T	D	0.600	T	T	T	0.123	0.341	0.508	0.539	T	T	T	T	D	D	2.756	22.900	0.993	D	D	0.412	4.417	0.471	4.903	0.571	0.707	0.725	0.725	0.684	.	5.380	5.380	5.981	1.307	0.751	1.000	1.000	0.998	863	.	.	.	.	PABPC1L	275	0	335	53	0.13659793814433	TRUE	NA
ENSG00000124126.14	.	BCM	GRCh38.p13	chr20	48650142	48650142	+	G	G	A	Missense_Mutation	SNP	ENST00000371941.4	exon24	c.C2882T	p.P961L	exonic	ENSG00000124126.14	.	nonsynonymous SNV	ENSG00000124126.14:ENST00000371941.4:exon24:c.C2882T:p.P961L	20q13.13	C3L-01037	0.0002	0.0003	0.0004	0.0002	0	0.0003	0	6.057e-05	rs41283554	3.20	D	T	B	B	U	N	L	T	D	0.106	T	T	T	0.058	.	0.300	0.351	T	T	T	T	T	T	2.135	20.400	0.970	D	N	-0.406	1.369	-0.296	1.572	0.977	0.706	0.702	0.710	0.714	.	5.710	3.720	3.002	0.230	-0.108	0.970	0.983	0.859	835	.	.	.	ID=COSV64248826;OCCURENCE=1(large_intestine),1(urinary_tract),1(skin),1(prostate)	PREX1	228	0	312	29	0.0850439882697947	TRUE	TRUE
ENSG00000169548.3	.	BCM	GRCh38.p13	chr22	22515456	22515456	+	C	C	T	Missense_Mutation	SNP	ENST00000302097.3	exon2	c.G175A	p.V59I	exonic	ENSG00000169548.3	.	nonsynonymous SNV	ENSG00000169548.3:ENST00000302097.3:exon2:c.G175A:p.V59I	22q11.22	C3L-01037	3.297e-05	0	0	0.0001	0	2.999e-05	0	6.057e-05	rs768517565	0.15	T	T	.	.	.	N	.	T	N	0.035	T	T	T	0.019	0.229	0.118	0.034	T	.	T	T	T	T	0.698	8.434	0.814	N	N	-1.254	0.192	-1.180	0.300	1.000	0.549	0.574	0.563	0.616	.	3.800	0.267	0.479	-0.340	-0.799	0.996	0.480	0.357	976	Domain_of_unknown_function_DUF4195	.	.	ID=COSV57479567;OCCURENCE=1(stomach)	ZNF280A	204	0	263	23	0.0804195804195804	TRUE	TRUE
ENSG00000102230.14	.	BCM	GRCh38.p13	chrX	24579369	24579369	+	G	G	A	Missense_Mutation	SNP	ENST00000379144.7	exon6	c.C655T	p.R219C	exonic	ENSG00000102230.14	.	nonsynonymous SNV	ENSG00000102230.14:ENST00000379144.7:exon6:c.C655T:p.R219C	Xp22.11	C3L-01037	.	.	.	.	.	.	.	.	.	18.18	D	D	D	D	D	D	M	.	D	0.808	D	D	D	0.892	0.670	0.924	2.582	D	D	D	D	D	D	4.497	32	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.090	5.090	9.593	1.176	0.676	1.000	0.988	0.988	276	.	.	.	.	PCYT1B	78	0	98	16	0.140350877192982	TRUE	TRUE
ENSG00000115760.14	.	BCM	GRCh38.p13	chr2	32467659	32467659	+	T	T	C	Silent	SNP	ENST00000421745.6	exon27	c.T5491C	p.L1831L	exonic	ENSG00000115760.14	.	synonymous SNV	ENSG00000115760.14:ENST00000421745.6:exon27:c.T5491C:p.L1831L	2p22.3	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BIRC6	308	0	417	35	0.0774336283185841	TRUE	NA
ENSG00000013810.19	.	BCM	GRCh38.p13	chr4	1727930	1727930	+	C	C	T	Silent	SNP	ENST00000313288.9	exon4	c.C528T	p.G176G	exonic	ENSG00000013810.19	.	synonymous SNV	ENSG00000013810.19:ENST00000313288.9:exon4:c.C528T:p.G176G	4p16.3	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TACC3	400	0	526	46	0.0804195804195804	TRUE	TRUE
ENSG00000137449.16	.	BCM	GRCh38.p13	chr4	15003153	15003153	+	C	C	T	Silent	SNP	ENST00000538197.6	exon1	c.C480T	p.T160T	exonic	ENSG00000137449.16	.	synonymous SNV	ENSG00000137449.16:ENST00000538197.6:exon1:c.C480T:p.T160T	4p15.32	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPEB2	114	0	186	11	0.0558375634517767	TRUE	NA
ENSG00000248383.4	.	BCM	GRCh38.p13	chr5	140927273	140927273	+	C	C	T	Silent	SNP	ENST00000253807.2	exon1	c.C381T	p.G127G	exonic	ENSG00000248383.4	.	synonymous SNV	ENSG00000248383.4:ENST00000253807.2:exon1:c.C381T:p.G127G	5q31.3	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHAC1	238	0	320	36	0.101123595505618	TRUE	TRUE
ENSG00000113209.9	.	BCM	GRCh38.p13	chr5	141136544	141136544	+	T	T	C	Silent	SNP	ENST00000231134.8	exon1	c.T1110C	p.S370S	exonic	ENSG00000113209.9	.	synonymous SNV	ENSG00000113209.9:ENST00000231134.8:exon1:c.T1110C:p.S370S	5q31.3	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHB5	224	1	289	27	0.0854430379746835	TRUE	TRUE
ENSG00000203734.12	.	BCM	GRCh38.p13	chr6	138885734	138885734	+	C	C	T	Silent	SNP	ENST00000541398.6	exon18	c.C2163T	p.Y721Y	exonic	ENSG00000203734.12	.	synonymous SNV	ENSG00000203734.12:ENST00000541398.6:exon18:c.C2163T:p.Y721Y	6q24.1	C3L-01037	7.457e-05	0.0001	0.0003	0	0	5.997e-05	0	0	rs192685430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ECT2L	168	0	207	22	0.0960698689956332	TRUE	NA
ENSG00000023287.13	.	BCM	GRCh38.p13	chr8	52642589	52642589	+	A	A	G	Silent	SNP	ENST00000025008.10	exon18	c.T4099C	p.L1367L	exonic	ENSG00000023287.13	.	synonymous SNV	ENSG00000023287.13:ENST00000025008.10:exon18:c.T4099C:p.L1367L	8q11.23	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RB1CC1	136	0	154	29	0.158469945355191	TRUE	TRUE
ENSG00000204291.11	.	BCM	GRCh38.p13	chr9	98986073	98986073	+	C	C	T	Silent	SNP	ENST00000375001.8	exon3	c.C609T	p.F203F	exonic	ENSG00000204291.11	.	synonymous SNV	ENSG00000204291.11:ENST00000375001.8:exon3:c.C609T:p.F203F	9q22.33	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66644569;OCCURENCE=1(prostate)	COL15A1	204	0	244	31	0.112727272727273	TRUE	TRUE
ENSG00000135472.9	.	BCM	GRCh38.p13	chr12	49870567	49870567	+	A	A	T	Silent	SNP	ENST00000320634.8	exon12	c.T888A	p.I296I	exonic	ENSG00000135472.9	.	synonymous SNV	ENSG00000135472.9:ENST00000320634.8:exon12:c.T888A:p.I296I	12q13.12	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAIM2	177	0	248	26	0.0948905109489051	TRUE	TRUE
ENSG00000188596.11	.	BCM	GRCh38.p13	chr12	96743496	96743496	+	G	G	A	Silent	SNP	ENST00000524981.9	exon53	c.G7314A	p.T2438T	exonic	ENSG00000188596.11	.	synonymous SNV	ENSG00000188596.11:ENST00000524981.9:exon53:c.G7314A:p.T2438T	12q23.1	C3L-01037	.	.	.	.	.	.	.	.	rs76379187	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CFAP54	325	1	413	46	0.100217864923747	TRUE	NA
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8123495	8123495	+	G	G	A	Silent	SNP	ENST00000600128.6	exon24	c.C3051T	p.F1017F	exonic	ENSG00000142449.13	.	synonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon24:c.C3051T:p.F1017F	19p13.2	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54462252;OCCURENCE=1(stomach),1(pancreas),2(skin),1(prostate)	FBN3	264	1	368	25	0.0636132315521628	TRUE	TRUE
ENSG00000130528.12	.	BCM	GRCh38.p13	chr19	49153594	49153594	+	G	G	A	Silent	SNP	ENST00000252825.9	exon1	c.C1644T	p.D548D	exonic	ENSG00000130528.12	.	synonymous SNV	ENSG00000130528.12:ENST00000252825.9:exon1:c.C1644T:p.D548D	19q13.33	C3L-01037	5.073e-05	0	0	0.0005	0	2.186e-05	0	0	rs148687983	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HRC	113	0	164	10	0.0574712643678161	TRUE	NA
ENSG00000125505.17	.	BCM	GRCh38.p13	chr19	54174302	54174302	+	C	C	T	Silent	SNP	ENST00000245615.6	exon8	c.G1161A	p.L387L	exonic	ENSG00000125505.17	.	synonymous SNV	ENSG00000125505.17:ENST00000245615.6:exon8:c.G1161A:p.L387L	19q13.42	C3L-01037	2.497e-05	0	0	0	0	4.546e-05	0	0	rs150838100	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MBOAT7	157	0	253	30	0.106007067137809	TRUE	NA
ENSG00000132622.11	.	BCM	GRCh38.p13	chr20	3749287	3749287	+	C	C	T	Silent	SNP	ENST00000254963.7	exon9	c.C906T	p.G302G	exonic	ENSG00000132622.11	.	synonymous SNV	ENSG00000132622.11:ENST00000254963.7:exon9:c.C906T:p.G302G	20p13	C3L-01037	8.925e-06	0.0001	0	0	0	0	0	0	rs149068732	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HSPA12B	359	0	472	31	0.0616302186878728	TRUE	NA
ENSG00000085224.22	.	BCM	GRCh38.p13	chrX	77693879	77693879	+	C	C	A	Silent	SNP	ENST00000373344.10	exon6	c.G429T	p.G143G	exonic	ENSG00000085224.22	.	synonymous SNV	ENSG00000085224.22:ENST00000373344.10:exon6:c.G429T:p.G143G	Xq21.1	C3L-01037	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATRX	192	0	187	35	0.157657657657658	TRUE	TRUE
ENSG00000181215.15	.	BCM	GRCh38.p13	chr4	6036072	6036072	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000181215.15;ENSG00000152969.20	dist=46425;dist=17685	.	.	4p16.1	C3L-01037	0.0033	0	0	0	0	0.0077	0	0	rs61734119	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C4orf50	230	0	301	39	0.114705882352941	TRUE	NA
ENSG00000180758.12	.	BCM	GRCh38.p13	chr1	9105579	9105579	+	G	G	C	Missense_Mutation	SNP	ENST00000377411.5	exon3	c.C699G	p.I233M	exonic	ENSG00000180758.12	.	nonsynonymous SNV	ENSG00000180758.12:ENST00000377411.5:exon3:c.C699G:p.I233M	1p36.22	C3N-03666	.	.	.	.	.	.	.	.	.	11.20	D	D	D	P	D	D	M	T	N	0.757	T	T	D	0.296	0.509	0.551	0.357	T	T	T	T	D	D	3.311	24.100	0.995	D	D	0.281	3.685	0.230	3.335	0.988	0.615	0.634	0.602	0.655	.	4.820	2.880	4.105	-0.190	-0.110	1.000	0.998	0.994	850	GPCR,_family_2-like	.	.	.	GPR157	151	0	236	21	0.0817120622568093	TRUE	TRUE
ENSG00000123473.15	.	BCM	GRCh38.p13	chr1	47300047	47300047	+	C	C	G	Missense_Mutation	SNP	ENST00000360380.7	exon7	c.G559C	p.D187H	exonic	ENSG00000123473.15	.	nonsynonymous SNV	ENSG00000123473.15:ENST00000360380.7:exon7:c.G559C:p.D187H	1p33	C3N-03666	.	.	.	.	.	.	.	.	.	7.20	D	D	D	P	N	N	M	T	N	0.542	T	T	T	0.117	0.229	0.767	0.517	T	T	T	T	D	D	3.413	24.400	0.994	D	N	0.431	4.543	0.399	4.349	0.111	0.707	0.654	0.725	0.636	.	5.470	4.550	2.565	0.130	0.599	0.993	0.977	0.987	656	.	.	.	.	STIL	185	0	303	25	0.0762195121951219	TRUE	TRUE
ENSG00000187862.12	.	BCM	GRCh38.p13	chr1	156582378	156582378	+	C	C	T	Missense_Mutation	SNP	ENST00000368236.7	exon3	c.C854T	p.A285V	exonic	ENSG00000187862.12	.	nonsynonymous SNV	ENSG00000187862.12:ENST00000368236.7:exon3:c.C854T:p.A285V	1q22	C3N-03666	9.127e-06	0.0001	0	0	0	0	0	0	rs574070584	3.20	T	T	B	B	N	N	L	T	N	0.293	T	T	D	0.149	0.435	0.577	0.301	T	T	T	T	D	T	2.377	22.000	0.997	D	N	0.081	2.810	0.098	2.726	1.000	0.387	0.655	0.573	0.542	.	4.380	3.450	3.509	0.138	0.599	0.842	0.383	0.872	697	Tetratricopeptide_repeat-containing_domain	.	.	ID=COSV63998350;OCCURENCE=1(stomach)	TTC24	284	0	526	39	0.0690265486725664	TRUE	TRUE
ENSG00000152382.6	.	BCM	GRCh38.p13	chr1	166876172	166876172	+	T	T	A	Missense_Mutation	SNP	ENST00000367874.5	exon1	c.A62T	p.D21V	exonic	ENSG00000152382.6	.	nonsynonymous SNV	ENSG00000152382.6:ENST00000367874.5:exon1:c.A62T:p.D21V	1q24.1	C3N-03666	.	.	.	.	.	.	.	.	.	12.20	D	D	B	B	D	D	L	T	D	0.423	T	T	D	0.267	0.281	0.361	0.525	D	T	D	T	D	D	3.741	25.600	0.976	D	D	-0.005	2.492	0.156	2.976	1.000	0.442	0.522	0.522	0.562	.	4.570	4.570	4.908	1.138	0.609	1.000	1.000	0.998	565	.	.	.	.	TADA1	167	0	301	84	0.218181818181818	TRUE	TRUE
ENSG00000135835.12	.	BCM	GRCh38.p13	chr1	180916242	180916242	+	G	G	A	Missense_Mutation	SNP	ENST00000367588.9	exon2	c.G139A	p.G47R	exonic	ENSG00000135835.12	.	nonsynonymous SNV	ENSG00000135835.12:ENST00000367588.9:exon2:c.G139A:p.G47R	1q25.3	C3N-03666	.	.	.	.	.	.	.	.	.	2.20	T	T	D	B	N	N	N	T	D	0.330	T	T	T	0.085	0.090	0.099	0.762	T	T	T	T	T	T	1.280	14.240	0.596	N	N	-0.643	0.912	-0.743	0.839	0.753	0.554	0.588	0.576	0.568	.	5.080	0.814	0.976	1.155	0.676	0.066	0.009	0.006	878	.	.	.	.	KIAA1614	90	0	165	11	0.0625	TRUE	NA
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237648474	237648474	+	C	C	T	Missense_Mutation	SNP	ENST00000366574.7	exon49	c.C7373T	p.A2458V	exonic	ENSG00000198626.17	.	nonsynonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon49:c.C7373T:p.A2458V	1q43	C3N-03666	1.153e-05	0	0	0	0	2.163e-05	0	0	rs768478443	18.19	D	.	D	D	D	D	M	D	D	0.792	D	D	D	0.773	0.336	0.926	0.978	T	D	D	D	D	D	4.028	27.200	0.999	D	D	0.805	8.888	0.766	9.196	0.906	0.554	0.574	0.602	0.564	.	5.160	5.160	6.066	1.026	0.599	1.000	0.999	0.996	889	.	.	.	ID=COSV63683125;OCCURENCE=1(central_nervous_system),1(stomach),1(lung)	RYR2	78	0	141	13	0.0844155844155844	TRUE	TRUE
ENSG00000115705.22	.	BCM	GRCh38.p13	chr2	1477149	1477149	+	G	G	A	Missense_Mutation	SNP	ENST00000329066.9	exon8	c.G883A	p.A295T	exonic	ENSG00000115705.22	.	nonsynonymous SNV	ENSG00000115705.22:ENST00000329066.9:exon8:c.G883A:p.A295T	2p25.3	C3N-03666	1.048e-05	0	0	0.0001	0	0	0	0	rs772197481	4.20	T	T	P	P	D	D	L	T	N	0.068	T	T	D	0.265	0.668	0.830	0.319	T	T	T	T	T	T	2.486	22.400	0.998	D	N	-0.047	2.348	-0.143	1.928	0.294	0.515	0.574	0.604	0.613	.	4.990	4.110	3.208	1.091	0.597	0.346	0.579	0.185	900	.	.	.	ID=COSV61097198;OCCURENCE=1(oesophagus),2(pancreas),1(endometrium)	TPO	275	0	260	34	0.115646258503401	TRUE	TRUE
ENSG00000152689.18	.	BCM	GRCh38.p13	chr2	33524505	33524505	+	G	G	A	Missense_Mutation	SNP	ENST00000403687.8	exon9	c.G764A	p.R255H	exonic	ENSG00000152689.18	.	nonsynonymous SNV	ENSG00000152689.18:ENST00000403687.8:exon9:c.G764A:p.R255H	2p22.3	C3N-03666	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.982	D	D	D	0.831	0.946	0.952	0.610	T	D	D	D	D	D	4.383	31	0.999	D	D	1.117	18.289	1.037	21.327	1.000	0.707	0.725	0.574	0.595	.	5.700	5.700	9.598	1.176	0.671	1.000	0.994	0.995	760	Ras_guanine-nucleotide_exchange_factors_catalytic_domain	.	.	ID=COSV101274728;OCCURENCE=1(stomach)	RASGRP3	227	0	327	24	0.0683760683760684	TRUE	NA
ENSG00000187123.15	.	BCM	GRCh38.p13	chr2	149437785	149437785	+	G	G	T	Missense_Mutation	SNP	ENST00000334166.9	exon2	c.G77T	p.R26L	exonic	ENSG00000187123.15	.	nonsynonymous SNV	ENSG00000187123.15:ENST00000334166.9:exon2:c.G77T:p.R26L	2q23.2	C3N-03666	.	.	.	.	.	.	.	.	.	11.20	D	D	D	P	D	D	L	T	D	0.851	T	T	T	0.196	0.375	0.407	0.595	T	T	D	T	D	D	3.992	26.900	0.998	D	D	0.674	6.769	0.683	7.451	0.519	0.693	0.547	0.659	0.668	.	5.630	4.750	6.368	1.176	0.618	1.000	1.000	0.982	537	.	.	.	.	LYPD6	278	0	401	49	0.108888888888889	TRUE	TRUE
ENSG00000153246.13	.	BCM	GRCh38.p13	chr2	159969258	159969258	+	G	G	A	Missense_Mutation	SNP	ENST00000283243.13	exon19	c.C2762T	p.T921I	exonic	ENSG00000153246.13	.	nonsynonymous SNV	ENSG00000153246.13:ENST00000283243.13:exon19:c.C2762T:p.T921I	2q24.2	C3N-03666	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	N	0.799	T	T	T	0.252	0.496	0.593	0.409	T	T	D	D	D	D	5.015	33	0.999	D	D	0.755	7.956	0.746	8.717	1.000	0.626	0.574	0.547	0.634	.	5.800	5.800	6.070	1.176	0.676	1.000	0.962	0.973	642	C-type_lectin-like;C-type_lectin,_conserved_site	.	.	.	PLA2R1	74	0	146	19	0.115151515151515	TRUE	TRUE
ENSG00000124006.15	.	BCM	GRCh38.p13	chr2	219557507	219557507	+	C	C	T	Missense_Mutation	SNP	ENST00000404537.6	exon12	c.G3902A	p.R1301H	exonic	ENSG00000124006.15	.	nonsynonymous SNV	ENSG00000124006.15:ENST00000404537.6:exon12:c.G3902A:p.R1301H	2q35	C3N-03666	0.0002	0	0	0	0	0	0	0.0004	rs746605175	5.19	T	D	D	D	.	D	L	T	N	0.497	T	T	D	0.317	0.412	0.850	0.752	T	T	T	T	T	T	3.031	23.500	0.998	N	N	0.360	4.104	0.291	3.666	1.000	0.635	0.574	0.644	0.563	.	3.900	3.900	0.881	1.026	0.599	0.071	0.989	0.978	114	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	OBSL1	101	0	136	15	0.0993377483443709	TRUE	NA
ENSG00000135905.19	.	BCM	GRCh38.p13	chr2	224837787	224837787	+	T	T	C	Missense_Mutation	SNP	ENST00000258390.11	exon25	c.A2825G	p.D942G	exonic	ENSG00000135905.19	.	nonsynonymous SNV	ENSG00000135905.19:ENST00000258390.11:exon25:c.A2825G:p.D942G	2q36.2	C3N-03666	.	.	.	.	.	.	.	.	.	10.20	D	D	P	P	D	D	M	T	D	0.569	T	T	T	0.216	0.343	0.461	0.405	T	T	T	T	D	D	4.505	32	0.998	D	D	0.403	4.365	0.422	4.517	1.000	0.707	0.725	0.574	0.617	.	5.670	5.670	7.674	1.138	0.665	1.000	0.603	0.873	835	.	.	.	.	DOCK10	248	0	357	23	0.0605263157894737	TRUE	TRUE
ENSG00000134115.13	.	BCM	GRCh38.p13	chr3	1383384	1383384	+	C	C	G	Missense_Mutation	SNP	ENST00000446702.7	exon19	c.C2493G	p.N831K	exonic	ENSG00000134115.13	.	nonsynonymous SNV	ENSG00000134115.13:ENST00000446702.7:exon19:c.C2493G:p.N831K	3p26.3	C3N-03666	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	D	N	T	N	0.479	T	T	T	0.098	0.373	0.778	0.007	T	T	T	T	T	D	2.292	21.500	0.997	D	N	0.130	3.007	0.267	3.528	0.863	0.487	0.574	0.547	0.564	.	5.740	5.740	0.343	1.026	0.549	0.970	1.000	0.997	938	Fibronectin_type_III	.	.	.	CNTN6	141	0	189	54	0.222222222222222	TRUE	TRUE
ENSG00000154814.14	.	BCM	GRCh38.p13	chr3	16286430	16286430	+	C	C	T	Missense_Mutation	SNP	ENST00000285083.10	exon5	c.C272T	p.S91F	exonic	ENSG00000154814.14	.	nonsynonymous SNV	ENSG00000154814.14:ENST00000285083.10:exon5:c.C272T:p.S91F	3p25.1	C3N-03666	.	.	.	.	.	.	.	.	.	8.20	D	D	P	P	N	D	M	T	D	0.403	T	T	T	0.136	0.512	0.488	0.040	T	T	T	T	D	D	3.289	24.100	0.998	D	N	0.398	4.330	0.357	4.070	1.000	0.732	0.623	0.744	0.636	.	4.970	4.970	1.270	0.874	0.599	0.953	0.860	0.665	855	FAD-binding_domain,_ferredoxin_reductase-type	.	.	.	OXNAD1	168	0	270	22	0.0753424657534247	TRUE	TRUE
ENSG00000114841.17	.	BCM	GRCh38.p13	chr3	52396660	52396660	+	C	C	T	Missense_Mutation	SNP	ENST00000420323.6	exon72	c.C11473T	p.H3825Y	exonic	ENSG00000114841.17	.	nonsynonymous SNV	ENSG00000114841.17:ENST00000420323.6:exon72:c.C11473T:p.H3825Y	3p21.1	C3N-03666	8.308e-06	0	0	0	0	0	0	6.093e-05	rs758459337	13.16	D	D	.	.	D	D	.	T	D	0.893	D	T	D	0.552	0.820	0.538	0.628	T	.	D	D	D	D	3.096	23.600	0.998	D	D	0.931	11.881	0.798	10.055	1.000	0.660	0.694	0.576	0.568	.	4.490	4.490	5.973	1.026	0.549	1.000	0.983	0.841	68	.	.	.	ID=COSV104610470;OCCURENCE=1(skin)	DNAH1	170	0	215	27	0.111570247933884	TRUE	NA
ENSG00000144857.14	.	BCM	GRCh38.p13	chr3	113249809	113249809	+	C	C	T	Missense_Mutation	SNP	ENST00000495514.5	exon3	c.C7T	p.R3C	exonic	ENSG00000144857.14	.	nonsynonymous SNV	ENSG00000144857.14:ENST00000495514.5:exon3:c.C7T:p.R3C	3q13.2	C3N-03666	1.651e-05	0	0.0002	0	0	0	0	0	rs764634173	6.20	D	D	B	B	N	D	N	D	D	0.222	T	T	D	0.133	0.522	0.864	0.312	T	T	T	T	T	T	1.853	18.120	0.998	N	N	-0.516	1.145	-0.408	1.357	1.000	0.706	0.563	0.710	0.530	.	5.200	4.330	1.599	1.026	0.597	0.046	0.028	0.122	421	.	.	.	ID=COSV56358734;OCCURENCE=1(large_intestine)	BOC	142	0	238	17	0.0666666666666667	TRUE	TRUE
ENSG00000174963.17	.	BCM	GRCh38.p13	chr3	147390947	147390947	+	C	C	T	Missense_Mutation	SNP	ENST00000383075.7	exon4	c.G988A	p.A330T	exonic	ENSG00000174963.17	.	nonsynonymous SNV	ENSG00000174963.17:ENST00000383075.7:exon4:c.G988A:p.A330T	3q24	C3N-03666	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	.	N	T	N	0.069	T	T	T	0.022	0.227	0.354	0.487	T	T	T	T	T	T	0.994	11.540	0.983	D	N	-1.056	0.347	-1.001	0.488	1.000	0.437	0.590	0.607	0.530	.	5.180	3.150	-0.253	0.096	0.524	0.000	0.243	0.321	898	.	.	.	.	ZIC4	104	0	157	31	0.164893617021277	TRUE	NA
ENSG00000121871.4	.	BCM	GRCh38.p13	chr3	165189207	165189207	+	G	G	C	Missense_Mutation	SNP	ENST00000475390.2	exon2	c.C1624G	p.L542V	exonic	ENSG00000121871.4	.	nonsynonymous SNV	ENSG00000121871.4:ENST00000475390.2:exon2:c.C1624G:p.L542V	3q26.1	C3N-03666	.	.	.	.	.	.	.	.	.	10.20	D	D	B	B	N	D	M	T	D	0.739	T	T	T	0.197	0.370	0.676	0.352	T	T	D	T	D	D	2.765	23.000	0.991	D	D	0.355	4.075	0.460	4.812	1.000	0.615	0.574	0.659	0.564	.	5.810	5.810	3.539	1.176	0.676	1.000	0.987	0.980	902	.	.	.	.	SLITRK3	222	0	334	22	0.0617977528089888	TRUE	TRUE
ENSG00000169836.5	.	BCM	GRCh38.p13	chr4	103719480	103719480	+	C	C	T	Missense_Mutation	SNP	ENST00000304883.3	exon1	c.G196A	p.A66T	exonic	ENSG00000169836.5	.	nonsynonymous SNV	ENSG00000169836.5:ENST00000304883.3:exon1:c.G196A:p.A66T	4q24	C3N-03666	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.050	T	T	T	0.112	0.245	0.741	0.315	T	T	T	T	T	T	1.678	16.880	0.986	N	N	-0.701	0.812	-0.601	1.044	0.999	0.447	0.563	0.504	0.555	.	4.780	4.780	0.526	0.865	0.549	0.000	0.039	0.958	479	.	.	.	.	TACR3	121	0	157	19	0.107954545454545	TRUE	TRUE
ENSG00000196159.12	.	BCM	GRCh38.p13	chr4	125449688	125449688	+	T	T	G	Missense_Mutation	SNP	ENST00000674496.1	exon9	c.T8672G	p.V2891G	exonic	ENSG00000196159.12	.	nonsynonymous SNV	ENSG00000196159.12:ENST00000674496.1:exon9:c.T8672G:p.V2891G	4q28.1	C3N-03666	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	U	D	H	T	D	0.763	D	D	D	0.687	0.712	0.831	0.745	T	D	D	D	D	T	3.923	26.500	0.996	D	D	0.942	12.196	0.852	11.861	1.000	0.707	0.574	0.574	0.714	.	5.510	5.510	7.859	1.138	0.665	1.000	0.996	0.752	922	Cadherin-like	.	.	.	FAT4	147	0	227	14	0.0580912863070539	TRUE	TRUE
ENSG00000197410.14	.	BCM	GRCh38.p13	chr4	154490239	154490239	+	G	G	A	Missense_Mutation	SNP	ENST00000357232.10	exon1	c.C1117T	p.R373C	exonic	ENSG00000197410.14	.	nonsynonymous SNV	ENSG00000197410.14:ENST00000357232.10:exon1:c.C1117T:p.R373C	4q31.3	C3N-03666	.	.	.	.	.	.	.	.	.	4.13	T	D	.	.	.	D	.	T	N	0.218	T	T	D	0.276	0.747	0.493	.	.	.	T	T	T	.	3.256	24.000	0.999	D	N	0.147	3.076	0.074	2.632	1.000	0.549	0.627	0.504	0.530	.	4.700	3.860	0.726	1.097	0.580	0.182	0.950	0.624	883	Cadherin-like	.	.	.	DCHS2	346	0	528	48	0.0833333333333333	TRUE	TRUE
ENSG00000150625.16	.	BCM	GRCh38.p13	chr4	175673745	175673745	+	C	C	A	Missense_Mutation	SNP	ENST00000280187.11	exon4	c.G322T	p.G108W	exonic	ENSG00000150625.16	.	nonsynonymous SNV	ENSG00000150625.16:ENST00000280187.11:exon4:c.G322T:p.G108W	4q34.2	C3N-03666	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.881	D	D	D	0.898	0.744	0.903	1.739	D	D	D	D	D	D	4.090	27.700	0.996	D	D	0.757	8.004	0.725	8.251	1.000	0.653	0.588	0.676	0.564	.	5.840	5.840	7.480	1.026	0.549	1.000	0.923	0.955	931	.	.	.	ID=COSV99704812;OCCURENCE=1(skin)	GPM6A	92	0	150	9	0.0566037735849057	TRUE	TRUE
ENSG00000170549.4	.	BCM	GRCh38.p13	chr5	3596316	3596316	+	G	G	A	Missense_Mutation	SNP	ENST00000302006.4	exon1	c.G211A	p.A71T	exonic	ENSG00000170549.4	.	nonsynonymous SNV	ENSG00000170549.4:ENST00000302006.4:exon1:c.G211A:p.A71T	5p15.33	C3N-03666	0.0002	0	0	0	0	0.0004	0	0	rs753639527	3.20	T	T	P	B	U	D	N	T	N	0.374	T	T	D	0.058	.	0.757	.	D	T	T	T	T	T	1.864	18.210	0.944	N	N	-0.579	1.026	-0.537	1.142	1.000	0.598	0.547	0.666	0.639	.	1.780	0.867	1.350	0.092	-0.374	0.919	0.857	0.728	987	.	.	.	.	IRX1	90	0	113	24	0.175182481751825	TRUE	NA
ENSG00000080709.16	.	BCM	GRCh38.p13	chr5	114362926	114362926	+	G	G	C	Missense_Mutation	SNP	ENST00000264773.7	exon1	c.G151C	p.A51P	exonic	ENSG00000080709.16	.	nonsynonymous SNV	ENSG00000080709.16:ENST00000264773.7:exon1:c.G151C:p.A51P	5q22.3	C3N-03666	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	N	D	N	D	N	0.292	D	D	D	0.330	0.286	0.269	0.561	D	T	T	T	T	T	2.165	20.600	0.957	N	N	-0.424	1.332	-0.306	1.552	1.000	0.496	0.476	0.240	0.555	.	3.960	3.000	1.348	1.134	0.654	0.969	0.896	0.851	879	.	.	.	.	KCNN2	396	1	499	58	0.104129263913824	TRUE	TRUE
ENSG00000184838.15	.	BCM	GRCh38.p13	chr5	120686258	120686258	+	G	G	A	Missense_Mutation	SNP	ENST00000407149.7	exon2	c.G464A	p.R155Q	exonic	ENSG00000184838.15	.	nonsynonymous SNV	ENSG00000184838.15:ENST00000407149.7:exon2:c.G464A:p.R155Q	5q23.1	C3N-03666	8.25e-06	9.63e-05	0	0	0	0	0	0	rs760368454	10.19	D	D	D	P	D	D	.	T	D	0.796	T	T	D	0.209	0.473	0.043	0.263	T	T	T	T	D	T	3.243	24.000	0.999	D	D	0.428	4.523	0.373	4.175	1.000	0.638	0.574	0.537	0.668	.	5.710	4.850	7.224	0.227	0.676	1.000	0.874	0.989	964	.	.	.	ID=COSV65394805;OCCURENCE=2(large_intestine),1(NS),9(skin)	PRR16	243	0	302	27	0.0820668693009119	TRUE	TRUE
ENSG00000138829.12	.	BCM	GRCh38.p13	chr5	128263534	128263534	+	C	C	T	Missense_Mutation	SNP	ENST00000262464.9	exon63	c.G8083A	p.D2695N	exonic	ENSG00000138829.12	.	nonsynonymous SNV	ENSG00000138829.12:ENST00000262464.9:exon63:c.G8083A:p.D2695N	5q23.3	C3N-03666	3.296e-05	0	0	0	0.0003	2.997e-05	0	0	rs775607402	16.19	D	.	D	D	D	D	L	D	D	0.866	D	D	D	0.653	0.882	0.842	0.487	T	D	D	T	D	D	3.901	26.400	0.999	D	D	0.581	5.737	0.495	5.115	1.000	0.732	0.574	0.805	0.728	.	5.240	5.240	7.905	1.026	0.599	1.000	0.270	0.483	749	EGF-like_domain;EGF-like_calcium-binding,_conserved_site;EGF-like_calcium-binding_domain	.	.	ID=COSV52554909;OCCURENCE=1(central_nervous_system),1(endometrium)	FBN2	473	0	578	66	0.102484472049689	TRUE	NA
ENSG00000158987.21	.	BCM	GRCh38.p13	chr5	131492625	131492625	+	G	G	C	Missense_Mutation	SNP	ENST00000509018.5	exon14	c.C1688G	p.P563R	exonic	ENSG00000158987.21;ENSG00000273217.1	.	nonsynonymous SNV	ENSG00000158987.21:ENST00000509018.5:exon14:c.C1688G:p.P563R,ENSG00000273217.1:ENST00000514667.1:exon15:c.C1838G:p.P613R	5q31.1	C3N-03666	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	N	0.348	T	T	T	0.084	0.615	0.225	0.231	T	T	T	T	T	D	2.392	22.100	0.995	D	N	0.118	2.960	0.288	3.650	1.000	0.651	0.654	0.659	0.684	.	6.040	6.040	1.830	1.176	0.676	0.819	0.999	0.999	387	PDZ_domain	.	.	.	RAPGEF6	307	5	481	27	0.0531496062992126	TRUE	TRUE
ENSG00000081818.4	.	BCM	GRCh38.p13	chr5	141123755	141123755	+	C	C	A	Missense_Mutation	SNP	ENST00000194152.4	exon1	c.C1757A	p.T586N	exonic	ENSG00000081818.4	.	nonsynonymous SNV	ENSG00000081818.4:ENST00000194152.4:exon1:c.C1757A:p.T586N	5q31.3	C3N-03666	.	.	.	.	.	.	.	.	.	10.19	D	D	D	P	.	D	M	T	D	0.415	D	T	T	0.178	0.709	0.417	.	T	T	T	T	D	D	2.683	22.800	0.989	D	N	0.254	3.553	0.060	2.577	0.001	0.554	0.574	0.602	0.621	.	3.770	1.840	0.989	-0.353	0.306	0.006	0.993	0.967	523	Cadherin-like	.	.	.	PCDHB4	859	1	896	106	0.105788423153693	NA	TRUE
ENSG00000113209.9	.	BCM	GRCh38.p13	chr5	141136221	141136221	+	G	G	A	Missense_Mutation	SNP	ENST00000231134.8	exon1	c.G787A	p.V263I	exonic	ENSG00000113209.9	.	nonsynonymous SNV	ENSG00000113209.9:ENST00000231134.8:exon1:c.G787A:p.V263I	5q31.3	C3N-03666	8.27e-06	0	0	0	0	0	0	6.09e-05	rs782126497	0.14	T	T	.	.	.	N	.	T	N	0.037	T	T	T	0.075	0.545	0.158	0.211	T	.	T	T	T	.	0.024	1.492	0.862	N	N	-1.286	0.173	-1.336	0.186	0.955	0.609	0.547	0.731	0.621	.	5.370	-5.750	-1.130	0.193	0.590	0.000	0.005	0.008	548	.	.	.	ID=COSV50658443;OCCURENCE=1(adrenal_gland),3(large_intestine),1(skin)	PCDHB5	149	1	167	21	0.111702127659574	TRUE	TRUE
ENSG00000120318.16	.	BCM	GRCh38.p13	chr5	141670057	141670057	+	G	G	A	Missense_Mutation	SNP	ENST00000239440.9	exon15	c.C2114T	p.P705L	exonic	ENSG00000120318.16	.	nonsynonymous SNV	ENSG00000120318.16:ENST00000239440.9:exon15:c.C2114T:p.P705L	5q31.3	C3N-03666	0.0003	0	0.0029	0	0	1.528e-05	0	6.12e-05	rs756578535	4.20	D	T	D	P	N	D	L	T	N	0.138	T	T	T	0.023	0.379	0.359	0.325	T	T	T	T	T	D	1.426	15.250	0.994	N	N	-0.437	1.303	-0.447	1.290	1.000	0.732	0.574	0.744	0.711	.	5.140	2.220	0.888	-0.183	0.676	0.833	0.639	0.778	732	Pleckstrin_homology_domain	.	.	.	ARAP3	102	0	147	13	0.08125	TRUE	NA
ENSG00000196569.12	.	BCM	GRCh38.p13	chr6	129486505	129486505	+	G	G	A	Missense_Mutation	SNP	ENST00000421865.2	exon56	c.G7781A	p.R2594H	exonic	ENSG00000196569.12	.	nonsynonymous SNV	ENSG00000196569.12:ENST00000421865.2:exon56:c.G7781A:p.R2594H	6q22.33	C3N-03666	2.475e-05	0	0	0	0	3e-05	0	6.058e-05	rs368311592	8.19	T	.	D	D	N	D	L	T	N	0.663	T	T	D	0.426	.	0.864	0.512	T	T	T	D	D	D	3.292	24.100	0.942	D	N	0.570	5.632	0.590	6.100	1.000	0.554	0.547	0.618	0.421	.	5.600	5.600	3.678	1.176	0.618	0.985	1.000	0.998	763	Laminin_G_domain	.	.	.	LAMA2	304	0	464	37	0.0738522954091816	TRUE	NA
ENSG00000074771.4	.	BCM	GRCh38.p13	chr6	155422783	155422783	+	C	C	T	Missense_Mutation	SNP	ENST00000159060.3	exon10	c.G1219A	p.A407T	exonic	ENSG00000074771.4	.	nonsynonymous SNV	ENSG00000074771.4:ENST00000159060.3:exon10:c.G1219A:p.A407T	6q25.3	C3N-03666	0.0001	0.0013	0	0	0	0	0	0	rs76198873	4.20	T	T	B	B	N	N	L	T	D	0.368	T	T	D	0.176	.	0.739	0.072	T	D	T	T	T	T	0.990	11.490	0.965	D	N	-0.660	0.881	-0.668	0.946	0.004	0.428	0.547	0.547	0.613	.	5.810	1.020	2.579	-0.666	-0.185	0.982	0.002	0.026	928	Ferric_reductase,_NAD_binding_domain	.	.	ID=COSV99342986;OCCURENCE=2(central_nervous_system)	NOX3	180	0	297	29	0.0889570552147239	TRUE	NA
ENSG00000198286.9	.	BCM	GRCh38.p13	chr7	2944271	2944271	+	C	C	T	Missense_Mutation	SNP	ENST00000396946.8	exon5	c.G625A	p.A209T	exonic	ENSG00000198286.9	.	nonsynonymous SNV	ENSG00000198286.9:ENST00000396946.8:exon5:c.G625A:p.A209T	7p22.2	C3N-03666	.	.	.	.	.	.	.	.	.	9.20	T	T	P	B	D	D	L	T	D	0.802	T	T	D	0.157	0.119	0.543	1.917	T	D	T	T	D	D	3.119	23.700	0.999	D	D	0.324	3.905	0.360	4.089	1.000	0.707	0.702	0.805	0.714	.	4.160	4.160	7.401	1.026	0.599	1.000	1.000	0.932	970	.	.	.	ID=COSV62717219;OCCURENCE=1(breast),1(genital_tract)	CARD11	274	1	347	25	0.0672043010752688	TRUE	TRUE
ENSG00000197123.9	.	BCM	GRCh38.p13	chr7	64260227	64260227	+	T	T	G	Missense_Mutation	SNP	ENST00000421025.3	exon3	c.T46G	p.L16V	exonic	ENSG00000197123.9	.	nonsynonymous SNV	ENSG00000197123.9:ENST00000421025.3:exon3:c.T46G:p.L16V	7q11.21	C3N-03666	.	.	.	.	.	.	.	.	.	1.19	D	T	B	B	.	N	L	T	N	0.142	T	T	T	0.066	0.583	0.270	0.017	T	T	T	T	T	T	0.631	7.809	0.808	N	N	-1.101	0.306	-1.192	0.290	0.000	0.487	0.574	0.574	0.564	.	0.195	0.195	-0.312	-0.237	0.336	0.045	0.004	0.031	851	Krueppel-associated_box	.	.	.	ZNF679	145	0	243	26	0.0966542750929368	TRUE	TRUE
ENSG00000077063.11	.	BCM	GRCh38.p13	chr7	117810800	117810800	+	C	C	T	Missense_Mutation	SNP	ENST00000160373.8	exon3	c.G379A	p.A127T	exonic	ENSG00000077063.11	.	nonsynonymous SNV	ENSG00000077063.11:ENST00000160373.8:exon3:c.G379A:p.A127T	7q31.31	C3N-03666	0.0002	0.0026	8.64e-05	0	0	1.499e-05	0	6.056e-05	rs143605688	2.20	T	T	B	B	N	D	L	T	N	0.129	T	T	T	0.072	.	0.285	0.094	T	T	T	T	T	T	1.055	12.290	0.852	D	N	-0.682	0.844	-0.579	1.078	1.000	0.742	0.590	0.775	0.564	.	5.770	-1.770	0.552	-0.345	-0.313	0.715	0.979	0.986	829	Cortactin-binding_protein-2,_N-terminal	.	.	ID=COSV50392180;OCCURENCE=1(large_intestine)	CTTNBP2	239	0	312	75	0.193798449612403	TRUE	TRUE
ENSG00000091879.14	.	BCM	GRCh38.p13	chr8	6519898	6519898	+	G	G	A	Missense_Mutation	SNP	ENST00000325203.9	exon5	c.C896T	p.T299M	exonic	ENSG00000091879.14	.	nonsynonymous SNV	ENSG00000091879.14:ENST00000325203.9:exon5:c.C896T:p.T299M	8p23.1	C3N-03666	0.0002	0.0018	8.637e-05	0	0	4.496e-05	0	0	rs61733318	13.20	D	D	D	D	D	D	M	T	D	0.306	D	D	D	0.189	.	0.833	0.059	T	T	T	T	T	T	2.524	22.500	0.963	D	D	0.052	2.700	0.010	2.393	1.000	0.632	0.547	0.574	0.742	.	5.240	4.370	5.146	-0.134	-0.127	1.000	0.079	0.337	967	Fibrinogen,_alpha/beta/gamma_chain,_C-terminal_globular_domain	.	.	.	ANGPT2	134	0	173	53	0.234513274336283	TRUE	NA
ENSG00000165084.16	.	BCM	GRCh38.p13	chr8	68521911	68521911	+	T	T	A	Missense_Mutation	SNP	ENST00000518698.6	exon6	c.T878A	p.I293N	exonic	ENSG00000165084.16	.	nonsynonymous SNV	ENSG00000165084.16:ENST00000518698.6:exon6:c.T878A:p.I293N	8q13.2	C3N-03666	.	.	.	.	.	.	.	.	.	7.18	D	D	P	P	N	N	L	T	D	0.393	T	T	T	0.056	0.129	0.550	0.545	.	.	T	T	D	D	2.922	23.300	0.993	D	D	0.044	2.671	0.107	2.765	0.010	0.554	0.574	0.602	0.564	.	5.590	4.440	5.112	1.138	0.665	1.000	0.926	0.975	652	.	.	.	.	C8orf34	89	0	207	22	0.0960698689956332	TRUE	TRUE
ENSG00000091656.19	.	BCM	GRCh38.p13	chr8	76851215	76851215	+	C	C	T	Missense_Mutation	SNP	ENST00000651372.2	exon10	c.C4294T	p.R1432C	exonic	ENSG00000091656.19	.	nonsynonymous SNV	ENSG00000091656.19:ENST00000651372.2:exon10:c.C4294T:p.R1432C	8q21.13	C3N-03666	0.0001	0	0.0010	0	0	6.039e-05	0	0	rs761737101	11.16	D	D	.	.	U	D	.	T	D	0.579	T	T	D	0.366	.	0.165	0.675	D	.	T	D	D	D	3.838	26.000	0.998	D	D	0.729	7.542	0.690	7.568	1.000	0.638	0.627	0.618	0.668	.	4.940	4.940	5.044	1.026	0.599	1.000	0.998	0.996	801	Zinc_finger_C2H2-type	.	.	ID=COSV50854696;OCCURENCE=1(cervix),1(stomach)	ZFHX4	171	0	258	53	0.170418006430868	TRUE	TRUE
ENSG00000104447.12	.	BCM	GRCh38.p13	chr8	115418392	115418392	+	G	G	A	Nonsense_Mutation	SNP	ENST00000640765.1	exon5	c.C2722T	p.R908X	exonic	ENSG00000104447.12	.	stopgain	ENSG00000104447.12:ENST00000640765.1:exon5:c.C2722T:p.R908X	8q23.3	C3N-03666	.	.	.	.	.	.	.	.	.	6.7	.	.	.	.	D	A	.	.	.	0.952	.	.	.	.	.	.	.	.	.	D	D	D	.	7.598	38	0.998	D	N	0.760	8.057	0.635	6.694	1.000	0.638	0.588	0.659	0.668	.	5.810	4.920	3.376	1.176	0.676	1.000	1.000	1.000	935	Zinc_finger,_GATA-type	.	.	ID=COSV55227212;OCCURENCE=5(large_intestine)	TRPS1	497	0	747	126	0.144329896907216	TRUE	TRUE
ENSG00000119121.22	.	BCM	GRCh38.p13	chr9	74840231	74840231	+	T	T	C	Missense_Mutation	SNP	ENST00000360774.6	exon5	c.A337G	p.R113G	exonic	ENSG00000119121.22	.	nonsynonymous SNV	ENSG00000119121.22:ENST00000360774.6:exon5:c.A337G:p.R113G	9q21.13	C3N-03666	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	H	T	D	0.927	T	T	D	0.474	0.719	0.420	1.025	T	D	D	D	D	D	3.204	23.900	0.997	D	N	0.220	3.392	0.070	2.616	0.000	0.554	0.588	0.547	0.564	.	5.860	0.058	1.156	-0.160	-0.126	0.843	0.974	0.990	648	.	.	.	.	TRPM6	257	0	289	41	0.124242424242424	TRUE	TRUE
ENSG00000214929.4	.	BCM	GRCh38.p13	chr9	81994315	81994315	+	G	G	T	Missense_Mutation	SNP	ENST00000344803.3	exon4	c.G3845T	p.C1282F	exonic	ENSG00000214929.4	.	nonsynonymous SNV	ENSG00000214929.4:ENST00000344803.3:exon4:c.G3845T:p.C1282F	9q21.32	C3N-03666	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	U	N	L	T	D	0.240	T	T	T	0.088	0.476	0.247	.	T	T	T	T	D	T	1.069	12.450	0.944	N	N	-0.882	0.543	-1.039	0.442	0.000	0.554	0.588	0.574	0.564	.	3.260	0.356	0.374	-0.126	-0.308	0.000	0.000	0.000	920	.	.	.	.	SPATA31D1	190	0	242	34	0.123188405797101	TRUE	TRUE
ENSG00000187239.17	.	BCM	GRCh38.p13	chr9	129900511	129900511	+	G	G	A	Missense_Mutation	SNP	ENST00000446176.7	exon14	c.C1465T	p.R489C	exonic	ENSG00000187239.17	.	nonsynonymous SNV	ENSG00000187239.17:ENST00000446176.7:exon14:c.C1465T:p.R489C	9q34.11	C3N-03666	.	.	.	.	.	.	.	.	rs367878072	10.20	D	D	P	P	D	N	M	T	D	0.667	D	T	D	0.337	.	0.715	0.538	T	T	T	T	D	D	3.123	23.700	0.999	D	N	0.104	2.902	0.020	2.427	1.000	0.706	0.602	0.710	0.636	.	4.020	4.020	2.119	1.163	0.616	0.912	0.092	0.262	450	.	.	.	.	FNBP1	69	0	87	16	0.155339805825243	TRUE	NA
ENSG00000148357.16	.	BCM	GRCh38.p13	chr9	130403223	130403223	+	G	G	A	Missense_Mutation	SNP	ENST00000624552.3	exon79	c.G11848A	p.V3950M	exonic	ENSG00000148357.16	.	nonsynonymous SNV	ENSG00000148357.16:ENST00000624552.3:exon79:c.G11848A:p.V3950M	9q34.11	C3N-03666	0.0021	0	0	0	0	0	0	0.0036	rs529803970	0.11	.	T	.	.	.	.	.	.	.	0.141	T	T	T	0.062	.	0.061	.	.	T	T	T	T	T	0.393	5.344	0.996	N	N	-0.585	1.016	-0.762	0.812	0.062	0.646	0.590	0.645	0.563	.	5.290	-1.280	-0.138	1.176	0.618	0.001	0.809	0.071	378	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV52983702;OCCURENCE=2(prostate)	HMCN2	159	0	218	21	0.0878661087866109	NA	TRUE
ENSG00000107611.16	.	BCM	GRCh38.p13	chr10	17111008	17111008	+	C	C	A	Missense_Mutation	SNP	ENST00000377833.10	exon9	c.G926T	p.C309F	exonic	ENSG00000107611.16	.	nonsynonymous SNV	ENSG00000107611.16:ENST00000377833.10:exon9:c.G926T:p.C309F	10p13	C3N-03666	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.960	D	D	D	0.976	0.968	0.919	0.549	T	D	D	D	D	D	3.600	25.000	0.993	D	D	1.105	17.706	0.999	18.806	1.000	0.556	0.574	0.685	0.613	.	5.830	5.830	7.763	1.026	0.599	1.000	0.982	0.983	750	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	CUBN	428	0	648	53	0.0756062767475036	TRUE	TRUE
ENSG00000177697.19	.	BCM	GRCh38.p13	chr11	836787	836787	+	A	A	C	Missense_Mutation	SNP	ENST00000397420.9	exon5	c.A295C	p.I99L	exonic	ENSG00000177697.19	.	nonsynonymous SNV	ENSG00000177697.19:ENST00000397420.9:exon5:c.A295C:p.I99L	11p15.5	C3N-03666	4.182e-05	0	0	0.0001	0	3.057e-05	0	0.0001	rs777391775	2.20	T	T	B	B	N	D	N	T	N	0.449	T	T	T	0.304	0.616	0.349	0.141	T	T	T	T	T	T	-1.208	0.002	0.712	N	D	-1.991	0.009	-2.025	0.012	1.000	0.722	0.607	0.644	0.735	.	4.610	-9.230	-1.720	-2.178	-2.641	0.000	0.019	0.033	856	.	.	.	ID=COSV100431921;OCCURENCE=1(kidney)	CD151	290	1	425	47	0.0995762711864407	TRUE	NA
ENSG00000129151.9	.	BCM	GRCh38.p13	chr11	27125679	27125679	+	C	C	T	Missense_Mutation	SNP	ENST00000263182.8	exon8	c.C862T	p.R288C	exonic	ENSG00000129151.9	.	nonsynonymous SNV	ENSG00000129151.9:ENST00000263182.8:exon8:c.C862T:p.R288C	11p14.2	C3N-03666	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.863	D	D	D	0.760	.	0.873	0.476	T	D	D	D	D	D	4.124	28.000	0.999	D	D	0.819	9.160	0.807	10.338	0.647	0.487	0.574	0.574	0.564	.	6.030	6.030	4.449	1.026	0.599	1.000	0.999	0.997	761	TauD/TfdA-like_domain	.	.	ID=COSV54191958;OCCURENCE=1(large_intestine)	BBOX1	105	0	136	17	0.111111111111111	TRUE	TRUE
ENSG00000149115.14	.	BCM	GRCh38.p13	chr11	57308885	57308885	+	C	C	T	Missense_Mutation	SNP	ENST00000358252.8	exon6	c.G3826A	p.V1276I	exonic	ENSG00000149115.14	.	nonsynonymous SNV	ENSG00000149115.14:ENST00000358252.8:exon6:c.G3826A:p.V1276I	11q12.1	C3N-03666	.	.	.	.	.	.	.	.	.	7.20	D	T	D	D	D	N	M	T	N	0.481	T	T	T	0.118	.	0.501	0.398	T	T	T	T	D	T	3.515	24.800	0.998	D	N	0.392	4.293	0.298	3.705	1.000	0.672	0.644	0.702	0.711	.	4.990	4.990	3.870	1.026	0.599	0.968	0.854	0.957	440	.	.	.	.	TNKS1BP1	320	1	497	28	0.0533333333333333	TRUE	NA
ENSG00000011347.10	.	BCM	GRCh38.p13	chr11	61518664	61518664	+	C	C	T	Missense_Mutation	SNP	ENST00000263846.8	exon9	c.G1175A	p.R392Q	exonic	ENSG00000011347.10	.	nonsynonymous SNV	ENSG00000011347.10:ENST00000263846.8:exon9:c.G1175A:p.R392Q	11q12.2	C3N-03666	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	N	D	M	T	D	0.643	D	T	D	0.518	0.513	0.845	2.024	T	D	T	T	D	D	3.752	25.600	0.999	D	D	0.295	3.751	0.185	3.109	1.000	0.696	0.590	0.723	0.613	.	3.480	2.570	5.724	1.026	-0.232	1.000	1.000	0.960	728	C2_domain;Synaptotagmin_7,_C2B_domain	.	.	.	SYT7	138	0	212	21	0.0901287553648069	TRUE	TRUE
ENSG00000126838.10	.	BCM	GRCh38.p13	chr12	9202362	9202362	+	C	C	T	Missense_Mutation	SNP	ENST00000261336.7	exon4	c.G437A	p.R146H	exonic	ENSG00000126838.10	.	nonsynonymous SNV	ENSG00000126838.10:ENST00000261336.7:exon4:c.G437A:p.R146H	12p13.31	C3N-03666	9.896e-05	0	0	0	0	0.0002	0	0	rs377706010	10.20	D	D	D	D	U	N	H	T	D	0.609	T	D	T	0.354	.	0.701	0.277	T	D	T	T	D	D	2.877	23.200	0.999	N	N	-0.273	1.682	-0.544	1.132	0.000	0.487	0.590	0.574	0.542	.	2.440	1.540	1.139	0.710	0.454	0.032	0.088	0.634	661	Alpha-2-macroglobulin,_N-terminal	.	.	ID=COSV54365920;OCCURENCE=1(stomach)	PZP	135	0	186	31	0.142857142857143	TRUE	TRUE
ENSG00000212126.3	.	BCM	GRCh38.p13	chr12	10986817	10986817	+	A	A	G	Missense_Mutation	SNP	ENST00000506868.1	exon1	c.T44C	p.V15A	exonic	ENSG00000212126.3	.	nonsynonymous SNV	ENSG00000212126.3:ENST00000506868.1:exon1:c.T44C:p.V15A	12p13.2	C3N-03666	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	L	T	N	0.021	T	T	T	0.067	0.680	0.130	0.018	T	T	T	T	T	.	-0.679	0.049	0.576	N	N	-1.272	0.180	-1.416	0.144	0.001	0.487	0.547	0.574	0.613	.	2.490	-4.510	-1.407	-0.500	-0.117	0.000	0.000	0.000	929	.	.	.	.	TAS2R50	54	0	80	7	0.0804597701149425	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-03666	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	242	0	359	67	0.157276995305164	TRUE	TRUE
ENSG00000133704.10	.	BCM	GRCh38.p13	chr12	30656733	30656733	+	C	C	A	Missense_Mutation	SNP	ENST00000256079.9	exon17	c.G1899T	p.E633D	exonic	ENSG00000133704.10	.	nonsynonymous SNV	ENSG00000133704.10:ENST00000256079.9:exon17:c.G1899T:p.E633D	12p11.21	C3N-03666	.	.	.	.	.	.	.	.	.	11.20	D	D	D	P	D	D	M	T	N	0.838	T	T	D	0.330	0.472	0.611	0.539	T	T	D	T	D	D	3.633	25.200	0.998	D	N	0.404	4.368	0.310	3.775	0.959	0.732	0.710	0.659	0.728	.	4.570	4.570	0.587	1.026	0.599	0.997	1.000	0.998	964	.	.	.	.	IPO8	92	0	182	13	0.0666666666666667	TRUE	TRUE
ENSG00000178882.15	.	BCM	GRCh38.p13	chr12	124314389	124314389	+	C	C	T	Missense_Mutation	SNP	ENST00000546355.4	exon3	c.C515T	p.P172L	exonic	ENSG00000178882.15	.	nonsynonymous SNV	ENSG00000178882.15:ENST00000546355.4:exon3:c.C515T:p.P172L	12q24.31	C3N-03666	.	.	.	.	.	.	.	.	.	15.18	D	D	D	D	D	D	.	.	D	0.947	D	T	D	0.688	0.759	0.319	1.097	T	T	D	D	D	D	4.035	27.200	0.999	D	D	0.772	8.265	0.710	7.943	1.000	0.707	0.588	0.645	0.714	.	4.700	4.700	7.442	1.026	0.599	1.000	0.996	0.951	559	.	.	.	.	RFLNA	553	1	611	123	0.167574931880109	TRUE	TRUE
ENSG00000136099.13	.	BCM	GRCh38.p13	chr13	52847874	52847874	+	C	C	T	Missense_Mutation	SNP	ENST00000377942.7	exon1	c.G563A	p.R188Q	exonic	ENSG00000136099.13	.	nonsynonymous SNV	ENSG00000136099.13:ENST00000377942.7:exon1:c.G563A:p.R188Q	13q14.3	C3N-03666	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	D	D	L	T	D	0.745	T	T	D	0.290	0.374	0.594	.	D	T	D	T	D	D	3.903	26.400	0.998	D	D	0.482	4.897	0.455	4.778	1.000	0.598	0.590	0.608	0.639	.	4.340	4.340	4.939	1.018	0.591	1.000	0.998	0.933	372	Cadherin-like	.	.	.	PCDH8	99	0	132	21	0.137254901960784	TRUE	TRUE
ENSG00000150361.12	.	BCM	GRCh38.p13	chr13	69719373	69719373	+	C	C	G	Missense_Mutation	SNP	ENST00000377844.9	exon9	c.G2011C	p.E671Q	exonic	ENSG00000150361.12	.	nonsynonymous SNV	ENSG00000150361.12:ENST00000377844.9:exon9:c.G2011C:p.E671Q	13q21.33	C3N-03666	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.942	D	D	D	0.841	0.551	0.961	0.372	T	D	D	D	D	D	3.952	26.700	0.998	D	D	0.888	10.739	0.857	12.036	1.000	0.487	0.574	0.574	0.564	.	5.820	5.820	7.905	1.026	0.599	1.000	1.000	0.994	965	.	.	.	.	KLHL1	141	0	266	18	0.0633802816901408	TRUE	NA
ENSG00000150361.12	.	BCM	GRCh38.p13	chr13	69719448	69719448	+	C	C	T	Missense_Mutation	SNP	ENST00000377844.9	exon9	c.G1936A	p.D646N	exonic	ENSG00000150361.12	.	nonsynonymous SNV	ENSG00000150361.12:ENST00000377844.9:exon9:c.G1936A:p.D646N	13q21.33	C3N-03666	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	N	T	N	0.309	T	T	T	0.296	0.595	0.780	0.059	T	T	T	T	D	D	2.114	20.200	0.481	D	N	-0.399	1.385	-0.098	2.052	0.977	0.487	0.574	0.574	0.564	.	5.680	5.680	3.385	1.026	0.599	0.999	0.845	0.889	965	.	.	.	.	KLHL1	306	0	617	53	0.0791044776119403	TRUE	TRUE
ENSG00000150361.12	.	BCM	GRCh38.p13	chr13	69719503	69719503	+	C	C	G	Missense_Mutation	SNP	ENST00000377844.9	exon9	c.G1881C	p.W627C	exonic	ENSG00000150361.12	.	nonsynonymous SNV	ENSG00000150361.12:ENST00000377844.9:exon9:c.G1881C:p.W627C	13q21.33	C3N-03666	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.973	D	D	D	0.935	0.816	0.983	0.465	D	D	D	D	D	D	4.388	31	0.993	D	D	1.173	21.531	1.062	23.260	1.000	0.487	0.574	0.574	0.564	.	5.820	5.820	7.905	1.026	0.599	1.000	1.000	0.999	965	.	.	.	.	KLHL1	275	0	562	38	0.0633333333333333	TRUE	TRUE
ENSG00000134900.12	.	BCM	GRCh38.p13	chr13	102636368	102636368	+	G	G	C	Missense_Mutation	SNP	ENST00000376065.8	exon13	c.G1654C	p.E552Q	exonic	ENSG00000134900.12	.	nonsynonymous SNV	ENSG00000134900.12:ENST00000376065.8:exon13:c.G1654C:p.E552Q	13q33.1	C3N-03666	.	.	.	.	.	.	.	.	.	11.19	D	T	D	P	D	D	M	.	N	0.845	T	T	T	0.279	0.429	0.289	1.550	T	T	D	D	D	D	4.000	27.000	0.998	D	D	0.773	8.283	0.827	10.957	1.000	0.707	0.725	0.725	0.714	.	6.040	6.040	9.602	1.176	0.618	1.000	1.000	0.997	920	.	.	.	.	TPP2	120	0	221	20	0.0829875518672199	TRUE	TRUE
ENSG00000041515.16	.	BCM	GRCh38.p13	chr13	109127448	109127448	+	C	C	A	Missense_Mutation	SNP	ENST00000356711.7	exon31	c.C3883A	p.Q1295K	exonic	ENSG00000041515.16	.	nonsynonymous SNV	ENSG00000041515.16:ENST00000356711.7:exon31:c.C3883A:p.Q1295K	13q33.3	C3N-03666	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	U	D	M	T	N	0.661	T	T	D	0.209	0.238	0.550	0.830	T	T	D	T	D	.	3.717	25.500	0.996	D	D	0.778	8.356	0.756	8.951	1.000	0.487	0.547	0.547	0.564	.	5.500	5.500	7.048	1.026	0.599	1.000	0.998	0.963	981	Neuronal_tyrosine-phosphorylated_phosphoinositide-3-kinase_adapter,_N-terminal	.	.	.	MYO16	220	0	361	34	0.0860759493670886	TRUE	TRUE
ENSG00000066735.14	.	BCM	GRCh38.p13	chr14	104175262	104175262	+	G	G	A	Missense_Mutation	SNP	ENST00000423312.6	exon12	c.G2474A	p.R825Q	exonic	ENSG00000066735.14	.	nonsynonymous SNV	ENSG00000066735.14:ENST00000423312.6:exon12:c.G2474A:p.R825Q	14q32.33	C3N-03666	8.367e-05	0.0001	0.0007	0	0	1.676e-05	0	0	rs756312971	5.19	D	T	B	B	.	N	M	T	D	0.123	T	T	D	0.162	0.285	0.921	0.095	T	T	T	T	T	T	2.300	21.600	0.999	D	N	-0.407	1.367	-0.357	1.452	0.814	0.696	0.588	0.723	0.700	.	3.810	1.870	0.347	1.079	0.672	0.322	0.597	0.251	557	.	.	.	.	KIF26A	294	0	447	40	0.082135523613963	TRUE	NA
ENSG00000215252.11	.	BCM	GRCh38.p13	chr15	34527972	34527972	+	C	C	A	Missense_Mutation	SNP	ENST00000342314.9	exon15	c.G1559T	p.S520I	exonic	ENSG00000215252.11	.	nonsynonymous SNV	ENSG00000215252.11:ENST00000342314.9:exon15:c.G1559T:p.S520I	15q14	C3N-03666	.	.	.	.	.	.	.	.	.	4.19	D	D	P	B	.	N	L	T	D	0.100	T	T	T	0.017	0.293	0.048	.	T	T	T	T	D	T	0.074	1.870	0.986	N	N	-0.805	0.648	-1.042	0.439	0.000	0.693	0.659	0.659	0.668	.	1.460	-1.130	-0.801	-0.650	0.185	0.000	0.000	0.002	420	.	.	.	.	GOLGA8B	40	0	46	10	0.178571428571429	NA	TRUE
ENSG00000140506.17	.	BCM	GRCh38.p13	chr15	74823573	74823573	+	G	G	A	Missense_Mutation	SNP	ENST00000309664.10	exon12	c.G1214A	p.R405H	exonic	ENSG00000140506.17	.	nonsynonymous SNV	ENSG00000140506.17:ENST00000309664.10:exon12:c.G1214A:p.R405H	15q24.1	C3N-03666	0.0001	0	0	0.0003	0	0	0	0.0007	rs543907196	0.20	T	T	B	B	N	N	L	T	N	0.159	T	T	T	0.018	0.359	0.165	0.088	T	T	T	T	T	T	0.038	1.590	0.865	N	N	-1.172	0.248	-1.238	0.253	1.000	0.497	0.590	0.578	0.613	.	5.180	-5.190	-0.885	0.224	0.676	0.000	0.821	0.426	308	.	.	.	.	LMAN1L	204	0	307	32	0.0943952802359882	TRUE	NA
ENSG00000167977.9	.	BCM	GRCh38.p13	chr16	2682589	2682589	+	G	G	A	Missense_Mutation	SNP	ENST00000301738.9	exon1	c.G41A	p.G14D	exonic	ENSG00000167977.9	.	nonsynonymous SNV	ENSG00000167977.9:ENST00000301738.9:exon1:c.G41A:p.G14D	16p13.3	C3N-03666	.	.	.	.	.	.	.	.	.	6.20	D	D	D	P	N	N	N	T	N	0.221	T	T	D	0.085	0.299	0.582	0.831	D	T	T	T	D	T	2.893	23.200	0.974	N	N	-0.159	1.996	-0.199	1.788	1.000	0.442	0.522	0.522	0.373	.	4.390	2.340	2.704	-0.147	-0.683	0.847	0.061	0.003	825	.	.	.	.	KCTD5	32	0	66	16	0.195121951219512	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673802	7673802	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G818A	p.R273H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G818A:p.R273H	17p13.1	C3N-03666	2.628e-05	0	0	0	0	4.746e-05	0	0	rs28934576	19.20	D	D	D	D	D	A	M	D	D	0.965	D	D	D	0.868	.	0.997	0.264	T	D	D	D	D	D	3.527	24.800	0.998	D	D	0.383	4.238	0.333	3.915	1.000	0.722	0.702	0.725	0.735	.	4.920	4.920	7.905	1.022	0.596	1.000	0.856	0.980	432	p53,_DNA-binding_domain	.	.	ID=COSV52660980;OCCURENCE=3(salivary_gland),135(breast),5(penis),9(liver),2(genital_tract),55(oesophagus),3(adrenal_gland),1(cervix),301(large_intestine),84(central_nervous_system),18(biliary_tract),1(fallopian_tube),1(pleura),4(vulva),73(ovary),8(bone),6(NS),57(haematopoietic_and_lymphoid_tissue),60(stomach),23(urinary_tract),7(soft_tissue),9(kidney),55(pancreas),15(skin),22(prostate),111(lung),11(thyroid),66(upper_aerodigestive_tract),2(thymus),41(endometrium)	TP53	565	1	617	149	0.194516971279373	TRUE	TRUE
ENSG00000004139.14	.	BCM	GRCh38.p13	chr17	28372451	28372451	+	-	NA	CT	Frame_Shift_Ins	INS	ENST00000585482.6	exon1	c.419_420insCT	p.R141Cfs*28	exonic	ENSG00000004139.14	.	frameshift insertion	ENSG00000004139.14:ENST00000585482.6:exon1:c.419_420insCT:p.R141Cfs*28	17q11.2	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SARM1	NA	NA	NA	NA	NA	NA	NA
ENSG00000176160.11	.	BCM	GRCh38.p13	chr17	58488014	58488014	+	G	G	T	Nonsense_Mutation	SNP	ENST00000323777.8	exon1	c.C261A	p.Y87X	exonic	ENSG00000176160.11	.	stopgain	ENSG00000176160.11:ENST00000323777.8:exon1:c.C261A:p.Y87X	17q22	C3N-03666	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.150	.	.	.	.	.	.	.	.	.	D	D	.	.	5.516	34	0.996	D	N	0.646	6.429	0.397	4.339	1.000	0.517	0.600	0.479	0.604	.	3.830	2.850	0.639	0.979	0.317	1.000	1.000	0.927	307	.	.	.	ID=COSV60204808;OCCURENCE=1(liver)	HSF5	589	0	723	75	0.093984962406015	TRUE	TRUE
ENSG00000108384.15	.	BCM	GRCh38.p13	chr17	58720779	58720779	+	G	G	A	Missense_Mutation	SNP	ENST00000337432.9	exon6	c.G871A	p.D291N	exonic	ENSG00000108384.15	.	nonsynonymous SNV	ENSG00000108384.15:ENST00000337432.9:exon6:c.G871A:p.D291N	17q22	C3N-03666	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	M	T	N	0.112	T	T	T	0.139	0.671	0.754	0.223	T	T	T	T	D	T	2.251	21.200	0.996	D	D	0.084	2.824	0.238	3.377	0.400	0.732	0.744	0.710	0.728	.	5.230	5.230	3.684	0.227	-0.186	1.000	1.000	0.994	543	Rad51/DMC1/RadA;DNA_recombination_and_repair_protein_Rad51-like,_C-terminal	.	.	.	RAD51C	210	0	349	64	0.154963680387409	TRUE	TRUE
ENSG00000108395.14	.	BCM	GRCh38.p13	chr17	59012378	59012378	+	C	C	G	Missense_Mutation	SNP	ENST00000262294.12	exon22	c.G2645C	p.G882A	exonic	ENSG00000108395.14	.	nonsynonymous SNV	ENSG00000108395.14:ENST00000262294.12:exon22:c.G2645C:p.G882A	17q22	C3N-03666	.	.	.	.	.	.	.	.	.	5.20	T	D	B	B	D	D	N	T	N	0.331	T	T	T	0.031	0.229	0.349	0.237	T	T	T	T	D	T	2.125	20.300	0.964	D	N	-0.053	2.328	0.089	2.689	0.002	0.732	0.654	0.710	0.728	.	5.860	4.870	1.870	1.026	0.599	0.942	0.995	0.985	496	.	.	.	.	TRIM37	327	1	699	60	0.0790513833992095	TRUE	TRUE
ENSG00000141367.12	.	BCM	GRCh38.p13	chr17	59644438	59644438	+	G	G	C	Missense_Mutation	SNP	ENST00000269122.8	exon2	c.G205C	p.D69H	exonic	ENSG00000141367.12	.	nonsynonymous SNV	ENSG00000141367.12:ENST00000269122.8:exon2:c.G205C:p.D69H	17q23.1	C3N-03666	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.940	D	D	D	0.816	0.666	0.894	2.206	D	D	D	D	D	D	4.256	29.200	0.995	D	D	0.796	8.693	0.760	9.034	1.000	0.707	0.725	0.725	0.714	.	4.910	4.910	9.899	1.176	0.676	1.000	0.998	0.928	808	.	.	.	.	CLTC	314	2	621	99	0.1375	TRUE	TRUE
ENSG00000136488.15	.	BCM	GRCh38.p13	chr17	63895744	63895744	+	G	G	T	Missense_Mutation	SNP	ENST00000316193.13	exon3	c.C278A	p.T93K	exonic	ENSG00000136488.15	.	nonsynonymous SNV	ENSG00000136488.15:ENST00000316193.13:exon3:c.C278A:p.T93K	17q23.3	C3N-03666	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	N	D	M	D	D	0.283	D	D	D	0.417	0.612	0.590	1.748	T	D	T	T	D	T	2.923	23.300	0.936	D	N	-0.175	1.947	-0.373	1.422	0.000	0.497	0.590	0.547	0.542	.	2.310	1.300	3.085	-0.492	-0.632	1.000	0.000	0.000	858	Somatotropin_hormone,_conserved_site	.	.	.	CSH1	22	0	24	6	0.2	NA	TRUE
ENSG00000196169.15	.	BCM	GRCh38.p13	chr17	74346496	74346496	+	G	G	A	Missense_Mutation	SNP	ENST00000389916.5	exon8	c.G896A	p.R299H	exonic	ENSG00000196169.15	.	nonsynonymous SNV	ENSG00000196169.15:ENST00000389916.5:exon8:c.G896A:p.R299H	17q25.1	C3N-03666	0	0	0	0	0	0	0	0	rs750093476	19.19	D	D	D	D	.	D	H	D	D	0.878	D	D	D	0.891	.	0.963	0.782	D	D	D	D	D	D	4.014	27.100	0.999	D	D	0.927	11.773	0.758	8.985	1.000	0.554	0.590	0.576	0.568	.	5.800	5.800	9.670	1.164	0.662	1.000	0.586	0.875	773	Kinesin_motor_domain	.	.	.	KIF19	133	0	170	28	0.141414141414141	TRUE	NA
ENSG00000175322.12	.	BCM	GRCh38.p13	chr18	14105537	14105537	+	G	G	T	Missense_Mutation	SNP	ENST00000590202.3	exon3	c.C1003A	p.L335I	exonic	ENSG00000175322.12	.	nonsynonymous SNV	ENSG00000175322.12:ENST00000590202.3:exon3:c.C1003A:p.L335I	18p11.21	C3N-03666	.	.	.	.	.	.	.	.	.	5.16	.	D	D	D	.	N	M	T	.	0.145	T	T	T	0.209	0.783	0.367	0.067	T	T	T	T	D	T	1.070	12.460	0.988	N	.	-0.104	2.161	-0.434	1.313	0.237	0.651	0.709	0.696	0.621	.	0.646	-0.809	0.136	-0.745	-0.728	0.009	0.002	0.001	958	Zinc_finger_C2H2-type	.	.	.	ZNF519	146	0	224	22	0.0894308943089431	NA	TRUE
ENSG00000185361.9	.	BCM	GRCh38.p13	chr19	4652311	4652311	+	G	G	A	Missense_Mutation	SNP	ENST00000327473.9	exon2	c.G442A	p.G148S	exonic	ENSG00000185361.9	.	nonsynonymous SNV	ENSG00000185361.9:ENST00000327473.9:exon2:c.G442A:p.G148S	19p13.3	C3N-03666	.	.	.	.	.	.	.	.	rs376296732	1.20	T	T	B	B	N	N	N	T	N	0.050	T	T	T	0.022	.	0.061	0.935	T	T	T	T	T	D	1.357	14.790	0.984	N	N	-0.631	0.932	-0.524	1.164	0.013	0.701	0.702	0.717	0.636	.	4.440	-1.320	0.823	0.191	0.584	0.999	0.565	0.855	964	.	.	.	ID=COSV59420535;OCCURENCE=1(pancreas)	TNFAIP8L1	254	0	300	51	0.145299145299145	TRUE	TRUE
ENSG00000181143.15	.	BCM	GRCh38.p13	chr19	8914273	8914273	+	G	G	A	Missense_Mutation	SNP	ENST00000397910.8	exon16	c.C36913T	p.R12305C	exonic	ENSG00000181143.15	.	nonsynonymous SNV	ENSG00000181143.15:ENST00000397910.8:exon16:c.C36913T:p.R12305C	19p13.2	C3N-03666	3.316e-05	0	0	0	0	4.5e-05	0	6.072e-05	rs367821186	2.15	D	D	.	.	.	N	.	T	N	0.355	T	T	T	0.063	.	0.333	.	T	.	T	T	T	T	1.672	16.840	0.253	N	N	-0.448	1.282	-0.686	0.920	0.000	0.554	0.574	0.618	0.564	.	2.570	1.460	-0.191	0.181	-0.188	0.000	0.016	0.000	934	SEA_domain	.	.	ID=COSV67441594;OCCURENCE=1(urinary_tract),1(skin),1(endometrium)	MUC16	174	0	203	22	0.0977777777777778	TRUE	TRUE
ENSG00000105143.12	.	BCM	GRCh38.p13	chr19	14950343	14950343	+	G	G	A	Missense_Mutation	SNP	ENST00000221742.7	exon9	c.C1547T	p.A516V	exonic	ENSG00000105143.12	.	nonsynonymous SNV	ENSG00000105143.12:ENST00000221742.7:exon9:c.C1547T:p.A516V	19p13.12	C3N-03666	0.0001	0	0	0.0007	0	9.071e-05	0.0011	0	rs146753676	16.20	D	D	D	D	D	D	M	T	D	0.822	T	T	D	0.597	.	0.811	2.376	T	D	D	D	D	D	3.280	24.100	0.999	D	D	0.677	6.814	0.578	5.956	0.970	0.615	0.574	0.616	0.564	.	5.430	4.390	9.826	1.136	0.665	1.000	0.277	0.180	976	.	.	.	ID=COSV55669433;OCCURENCE=1(lung)	SLC1A6	56	0	69	8	0.103896103896104	TRUE	NA
ENSG00000099331.13	.	BCM	GRCh38.p13	chr19	17212269	17212269	+	A	A	G	Missense_Mutation	SNP	ENST00000594824.5	exon40	c.A6433G	p.T2145A	exonic	ENSG00000099331.13	.	nonsynonymous SNV	ENSG00000099331.13:ENST00000594824.5:exon40:c.A6433G:p.T2145A	19p13.11	C3N-03666	0.0003	0.0005	0	0	0	0.0003	0.0050	0.0002	rs751808879	2.15	.	T	.	.	N	N	.	D	.	0.120	T	T	D	0.109	.	0.610	.	T	T	T	T	T	T	0.760	9.007	0.748	N	N	-0.609	0.971	-0.568	1.094	0.001	0.707	0.702	0.723	0.714	.	4.830	3.730	0.489	1.202	0.686	0.000	0.659	0.152	917	.	.	.	.	MYO9B	70	0	98	16	0.140350877192982	TRUE	NA
ENSG00000089335.21	.	BCM	GRCh38.p13	chr19	34684379	34684379	+	G	G	C	Missense_Mutation	SNP	ENST00000505242.6	exon5	c.G342C	p.K114N	exonic	ENSG00000089335.21	.	nonsynonymous SNV	ENSG00000089335.21:ENST00000505242.6:exon5:c.G342C:p.K114N	19q13.11	C3N-03666	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	.	N	.	T	N	0.121	T	T	T	0.016	0.303	0.072	0.057	T	T	T	T	T	T	0.235	3.532	0.952	N	N	-1.045	0.358	-1.150	0.327	0.983	0.732	0.744	0.651	0.728	.	0.967	-0.248	-0.570	-0.957	-0.490	0.002	0.001	0.044	484	.	.	.	.	ZNF302	68	0	131	15	0.102739726027397	TRUE	TRUE
ENSG00000197497.11	.	BCM	GRCh38.p13	chr19	53164682	53164682	+	C	C	T	Missense_Mutation	SNP	ENST00000396424.5	exon4	c.G1808A	p.C603Y	exonic	ENSG00000197497.11	.	nonsynonymous SNV	ENSG00000197497.11:ENST00000396424.5:exon4:c.G1808A:p.C603Y	19q13.42	C3N-03666	1.649e-05	0	0	0.0002	0	0	0	0	rs781368210	12.19	D	D	D	D	.	N	H	D	D	0.393	D	D	T	0.229	0.740	0.840	0.274	T	T	T	T	D	T	2.679	22.800	0.957	D	D	0.264	3.599	-0.034	2.246	0.003	0.615	0.588	0.659	0.605	.	2.300	1.220	4.064	0.748	0.490	0.986	0.002	0.006	994	Zinc_finger_C2H2-type	.	.	.	ZNF665	133	0	184	28	0.132075471698113	TRUE	NA
ENSG00000167614.14	.	BCM	GRCh38.p13	chr19	54419227	54419227	+	G	G	A	Missense_Mutation	SNP	ENST00000376530.8	exon2	c.G226A	p.E76K	exonic	ENSG00000167614.14	.	nonsynonymous SNV	ENSG00000167614.14:ENST00000376530.8:exon2:c.G226A:p.E76K	19q13.42	C3N-03666	1.69e-05	0	0	0	0	3.096e-05	0	0	rs752243868	5.20	T	D	D	D	N	N	L	T	N	0.488	T	T	T	0.116	0.589	0.068	0.407	T	T	T	T	D	T	2.315	21.700	0.999	D	N	-0.051	2.335	-0.033	2.250	1.000	0.598	0.578	0.269	0.639	.	3.510	3.510	3.773	1.176	0.676	0.999	0.402	0.576	988	.	.	.	.	TTYH1	141	0	249	21	0.0777777777777778	TRUE	NA
ENSG00000242019.1	.	BCM	GRCh38.p13	chr19	54729774	54729774	+	G	G	A	Missense_Mutation	SNP	ENST00000291860.1	exon5	c.G937A	p.V313I	exonic	ENSG00000242019.1	.	nonsynonymous SNV	ENSG00000242019.1:ENST00000291860.1:exon5:c.G937A:p.V313I	19q13.42	C3N-03666	.	.	.	.	.	.	.	.	rs111516669	0.14	T	T	.	.	.	N	.	T	N	0.025	T	T	T	0.008	0.427	0.043	1.508	T	.	T	T	T	.	-1.459	0.001	0.793	N	N	-1.796	0.024	-1.887	0.023	0.000	0.487	0.563	0.574	0.564	.	1.370	-2.730	-1.590	-4.799	-4.978	0.000	0.000	0.000	952	Immunoglobulin_subtype	.	.	.	KIR3DL3	128	0	208	17	0.0755555555555556	TRUE	NA
ENSG00000185982.7	.	BCM	GRCh38.p13	chr20	188045	188045	+	T	T	A	Missense_Mutation	SNP	ENST00000334391.5	exon2	c.A123T	p.R41S	exonic	ENSG00000185982.7	.	nonsynonymous SNV	ENSG00000185982.7:ENST00000334391.5:exon2:c.A123T:p.R41S	20p13	C3N-03666	.	.	.	.	.	.	.	.	.	2.19	D	T	B	B	N	N	.	T	N	0.165	T	T	T	0.037	0.237	0.043	0.008	T	T	T	T	D	T	1.104	12.810	0.867	N	N	-0.997	0.407	-1.051	0.429	0.000	0.487	0.574	0.574	0.530	.	4.410	-0.957	-0.046	-0.168	-0.995	0.527	0.122	0.027	952	.	.	.	.	DEFB128	364	0	675	70	0.0939597315436242	TRUE	TRUE
ENSG00000154654.15	.	BCM	GRCh38.p13	chr21	21477338	21477338	+	A	A	T	Missense_Mutation	SNP	ENST00000400546.6	exon15	c.A1944T	p.K648N	exonic	ENSG00000154654.15	.	nonsynonymous SNV	ENSG00000154654.15:ENST00000400546.6:exon15:c.A1944T:p.K648N	21q21.1	C3N-03666	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	L	T	N	0.144	T	T	T	0.049	0.428	0.386	0.668	T	T	T	T	T	T	1.910	18.560	0.994	D	N	-0.520	1.138	-0.306	1.551	0.012	0.554	0.574	0.618	0.621	.	5.800	3.480	1.474	0.292	-0.070	1.000	1.000	0.988	984	Fibronectin_type_III	.	.	.	NCAM2	65	0	95	9	0.0865384615384615	TRUE	TRUE
ENSG00000181544.15	.	BCM	GRCh38.p13	chrX	14844654	14844654	+	T	T	G	Missense_Mutation	SNP	ENST00000650831.1	exon9	c.A2014C	p.M672L	exonic	ENSG00000181544.15	.	nonsynonymous SNV	ENSG00000181544.15:ENST00000650831.1:exon9:c.A2014C:p.M672L	Xp22.2	C3N-03666	.	.	.	.	.	.	.	.	.	1.18	T	T	B	B	N	N	M	.	N	0.255	T	T	T	0.083	0.305	0.231	0.096	T	T	T	T	T	T	-0.509	0.114	0.395	N	.	.	.	.	.	0.999	.	.	.	.	.	5.500	-6.540	-0.313	-2.301	-0.718	0.049	0.001	0.088	98	.	.	.	.	FANCB	103	0	176	31	0.14975845410628	TRUE	TRUE
ENSG00000184735.7	.	BCM	GRCh38.p13	chrX	23001382	23001382	+	A	A	C	Missense_Mutation	SNP	ENST00000327968.7	exon1	c.A1325C	p.K442T	exonic	ENSG00000184735.7	.	nonsynonymous SNV	ENSG00000184735.7:ENST00000327968.7:exon1:c.A1325C:p.K442T	Xp22.11	C3N-03666	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	U	N	N	T	N	0.117	T	T	T	0.067	0.486	0.068	0.114	T	T	T	T	T	T	0.216	3.306	0.523	D	.	.	.	.	.	0.000	.	.	.	.	.	4.190	1.600	1.532	-0.230	-0.116	0.674	0.647	0.003	974	Helicase_superfamily_1/2,_ATP-binding_domain;Helicase,_C-terminal	.	.	.	DDX53	52	0	52	6	0.103448275862069	TRUE	TRUE
ENSG00000123131.13	.	BCM	GRCh38.p13	chrX	23671607	23671607	+	G	G	A	Missense_Mutation	SNP	ENST00000379341.9	exon2	c.G320A	p.R107H	exonic	ENSG00000123131.13	.	nonsynonymous SNV	ENSG00000123131.13:ENST00000379341.9:exon2:c.G320A:p.R107H	Xp22.11	C3N-03666	2.365e-05	0	0.0002	0	0	0	0	0	rs775157258	8.19	D	D	B	B	N	N	M	T	D	0.115	T	T	D	0.173	0.657	0.718	0.917	T	T	T	T	D	D	2.686	22.800	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.340	3.310	2.291	1.176	0.674	1.000	1.000	1.000	748	Alkyl_hydroperoxide_reductase_subunit_C/_Thiol_specific_antioxidant;Thioredoxin_domain	.	.	.	PRDX4	66	0	95	14	0.128440366972477	TRUE	NA
ENSG00000198934.5	.	BCM	GRCh38.p13	chrX	76428400	76428400	+	C	C	A	Missense_Mutation	SNP	ENST00000361470.4	exon1	c.C470A	p.S157Y	exonic	ENSG00000198934.5	.	nonsynonymous SNV	ENSG00000198934.5:ENST00000361470.4:exon1:c.C470A:p.S157Y	Xq13.3	C3N-03666	.	.	.	.	.	.	.	.	.	3.18	D	D	P	B	.	N	L	T	N	0.113	T	T	D	0.070	0.198	0.043	0.807	T	T	T	T	T	T	1.334	14.630	0.775	N	.	.	.	.	.	1.000	.	.	.	.	.	1.960	-0.100	-0.161	-1.752	-1.063	0.002	0.000	0.000	203	.	.	.	.	MAGEE1	184	2	244	14	0.0542635658914729	NA	TRUE
ENSG00000174740.8	.	BCM	GRCh38.p13	chrX	91436184	91436184	+	G	G	A	Missense_Mutation	SNP	ENST00000312600.4	exon2	c.G607A	p.V203I	exonic	ENSG00000174740.8	.	nonsynonymous SNV	ENSG00000174740.8:ENST00000312600.4:exon2:c.G607A:p.V203I	Xq21.31	C3N-03666	.	.	.	.	.	.	.	.	.	6.19	T	T	B	B	D	D	N	T	N	0.129	T	T	D	0.097	0.574	0.569	0.581	T	T	T	T	D	D	1.682	16.910	0.886	D	.	.	.	.	.	0.997	.	.	.	.	.	4.530	2.770	7.427	1.062	0.676	1.000	0.998	0.998	949	RNA_recognition_motif_domain;RNA_recognition_motif_domain,_eukaryote	.	.	ID=COSV57040474;OCCURENCE=1(large_intestine),2(central_nervous_system),1(endometrium)	PABPC5	161	0	207	39	0.158536585365854	TRUE	TRUE
ENSG00000133138.20	.	BCM	GRCh38.p13	chrX	106873822	106873824	+	CAG	CAG	-	In_Frame_Del	DEL	ENST00000357242.10	exon21	c.3220_3222del	p.Q1074del	exonic	ENSG00000133138.20	.	nonframeshift deletion	ENSG00000133138.20:ENST00000357242.10:exon21:c.3220_3222del:p.Q1074del	Xq22.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBC1D8B	82	0	90	27	0.230769230769231	TRUE	TRUE
ENSG00000133138.20	.	BCM	GRCh38.p13	chrX	106873827	106873830	+	GTCA	GTCA	-	Frame_Shift_Del	DEL	ENST00000357242.10	exon21	c.3225_3228del	p.W1075Cfs*12	exonic	ENSG00000133138.20	.	frameshift deletion	ENSG00000133138.20:ENST00000357242.10:exon21:c.3225_3228del:p.W1075Cfs*12	Xq22.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBC1D8B	83	0	98	25	0.203252032520325	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178732065	178732065	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000155657.27	ENST00000591111.5:exon55:c.15952+1G>T	.	.	2q31.2	C3N-03666	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.719	34	0.992	D	.	1.247	28.955	1.122	29.816	1.000	0.054	0.063	0.060	0.057	0.991	6.170	6.170	7.568	1.026	0.599	1.000	0.979	0.964	341	.	.	.	.	TTN	33	0	41	4	0.0888888888888889	TRUE	TRUE
ENSG00000009724.17	.	BCM	GRCh38.p13	chr1	11046966	11046966	+	G	G	A	Silent	SNP	ENST00000400897.8	exon2	c.C159T	p.P53P	exonic	ENSG00000009724.17	.	synonymous SNV	ENSG00000009724.17:ENST00000400897.8:exon2:c.C159T:p.P53P	1p36.22	C3N-03666	0.0002	0	0	0	0	0.0005	0	0	rs376802078	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MASP2	346	0	377	43	0.102380952380952	TRUE	NA
ENSG00000142794.18	.	BCM	GRCh38.p13	chr1	21483212	21483212	+	G	G	A	Silent	SNP	ENST00000318249.9	exon15	c.G1728A	p.S576S	exonic	ENSG00000142794.18	.	synonymous SNV	ENSG00000142794.18:ENST00000318249.9:exon15:c.G1728A:p.S576S	1p36.12	C3N-03666	8.454e-06	0	0	0	0	0	0	6.119e-05	rs775331586	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59058154;OCCURENCE=1(liver),1(large_intestine)	NBPF3	124	0	162	22	0.119565217391304	NA	TRUE
ENSG00000116783.15	.	BCM	GRCh38.p13	chr1	74353982	74353982	+	T	T	C	Silent	SNP	ENST00000326637.8	exon11	c.T1030C	p.L344L	exonic	ENSG00000116783.15;ENSG00000259030.7	.	synonymous SNV	ENSG00000116783.15:ENST00000326637.8:exon11:c.T1030C:p.L344L,ENSG00000259030.7:ENST00000557284.6:exon13:c.T1372C:p.L458L	1p31.1	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TNNI3K	91	0	135	22	0.140127388535032	TRUE	TRUE
ENSG00000132718.9	.	BCM	GRCh38.p13	chr1	155880595	155880595	+	G	G	A	Silent	SNP	ENST00000368324.5	exon3	c.G957A	p.P319P	exonic	ENSG00000132718.9	.	synonymous SNV	ENSG00000132718.9:ENST00000368324.5:exon3:c.G957A:p.P319P	1q22	C3N-03666	3.295e-05	0	0	0.0002	0	2.997e-05	0	0	rs370047410	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SYT11	158	0	231	81	0.259615384615385	TRUE	NA
ENSG00000143337.18	.	BCM	GRCh38.p13	chr1	179914032	179914032	+	G	G	A	Silent	SNP	ENST00000606911.6	exon9	c.G942A	p.Q314Q	exonic	ENSG00000143337.18	.	synonymous SNV	ENSG00000143337.18:ENST00000606911.6:exon9:c.G942A:p.Q314Q	1q25.2	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TOR1AIP1	148	0	321	19	0.0558823529411765	TRUE	NA
ENSG00000197721.17	.	BCM	GRCh38.p13	chr1	207697606	207697606	+	C	C	T	Silent	SNP	ENST00000508064.7	exon6	c.C966T	p.Y322Y	exonic	ENSG00000197721.17	.	synonymous SNV	ENSG00000197721.17:ENST00000508064.7:exon6:c.C966T:p.Y322Y	1q32.2	C3N-03666	0.0098	0.0006	0.0327	0.0478	0.0183	0.0033	0.0134	0.0022	rs151335737	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54329371;OCCURENCE=1(lung)	CR1L	402	0	802	51	0.05978898007034	NA	TRUE
ENSG00000135951.16	.	BCM	GRCh38.p13	chr2	99081283	99081283	+	A	A	T	Silent	SNP	ENST00000393483.8	exon11	c.T726A	p.I242I	exonic	ENSG00000135951.16	.	synonymous SNV	ENSG00000135951.16:ENST00000393483.8:exon11:c.T726A:p.I242I	2q11.2	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TSGA10	71	0	76	15	0.164835164835165	TRUE	TRUE
ENSG00000169760.17	.	BCM	GRCh38.p13	chr3	174279090	174279090	+	T	T	C	Silent	SNP	ENST00000457714.5	exon6	c.T1089C	p.D363D	exonic	ENSG00000169760.17	.	synonymous SNV	ENSG00000169760.17:ENST00000457714.5:exon6:c.T1089C:p.D363D	3q26.31	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NLGN1	102	0	155	76	0.329004329004329	TRUE	TRUE
ENSG00000151726.14	.	BCM	GRCh38.p13	chr4	184763176	184763176	+	G	G	A	Silent	SNP	ENST00000515030.5	exon16	c.C1512T	p.G504G	exonic	ENSG00000151726.14	.	synonymous SNV	ENSG00000151726.14:ENST00000515030.5:exon16:c.C1512T:p.G504G	4q35.1	C3N-03666	0.0001	0	0	0	0.0002	0.0002	0	0	rs370223408	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55668052;OCCURENCE=1(cervix)	ACSL1	238	0	349	25	0.0668449197860963	TRUE	NA
ENSG00000078295.17	.	BCM	GRCh38.p13	chr5	7816961	7816961	+	C	C	T	Silent	SNP	ENST00000338316.9	exon23	c.C2979T	p.N993N	exonic	ENSG00000078295.17	.	synonymous SNV	ENSG00000078295.17:ENST00000338316.9:exon23:c.C2979T:p.N993N	5p15.31	C3N-03666	.	.	.	.	.	.	.	.	rs958554402	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100601497;OCCURENCE=1(stomach)	ADCY2	182	0	236	58	0.197278911564626	TRUE	NA
ENSG00000040731.10	.	BCM	GRCh38.p13	chr5	24537567	24537567	+	G	G	T	Silent	SNP	ENST00000264463.8	exon3	c.C339A	p.A113A	exonic	ENSG00000040731.10	.	synonymous SNV	ENSG00000040731.10:ENST00000264463.8:exon3:c.C339A:p.A113A	5p14.2	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100053091;OCCURENCE=1(lung)	CDH10	280	0	423	44	0.0942184154175589	TRUE	TRUE
ENSG00000124818.15	.	BCM	GRCh38.p13	chr6	47795443	47795443	+	G	G	A	Silent	SNP	ENST00000371211.6	exon4	c.G636A	p.T212T	exonic	ENSG00000124818.15	.	synonymous SNV	ENSG00000124818.15:ENST00000371211.6:exon4:c.G636A:p.T212T	6p12.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99790030;OCCURENCE=1(central_nervous_system)	OPN5	289	0	427	37	0.0797413793103448	TRUE	TRUE
ENSG00000135317.13	.	BCM	GRCh38.p13	chr6	85547335	85547335	+	A	A	T	Silent	SNP	ENST00000314673.8	exon11	c.T975A	p.P325P	exonic	ENSG00000135317.13	.	synonymous SNV	ENSG00000135317.13:ENST00000314673.8:exon11:c.T975A:p.P325P	6q14.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SNX14	153	0	285	31	0.0981012658227848	TRUE	TRUE
ENSG00000164880.16	.	BCM	GRCh38.p13	chr7	1484117	1484117	+	C	C	A	Silent	SNP	ENST00000404767.8	exon25	c.G3315T	p.S1105S	exonic	ENSG00000164880.16	.	synonymous SNV	ENSG00000164880.16:ENST00000404767.8:exon25:c.G3315T:p.S1105S	7p22.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INTS1	137	0	211	45	0.17578125	TRUE	TRUE
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	2942513	2942513	+	A	A	G	Silent	SNP	ENST00000635120.2	exon69	c.T10494C	p.A3498A	exonic	ENSG00000183117.19	.	synonymous SNV	ENSG00000183117.19:ENST00000635120.2:exon69:c.T10494C:p.A3498A	8p23.2	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CSMD1	116	0	207	28	0.119148936170213	TRUE	TRUE
ENSG00000147416.11	.	BCM	GRCh38.p13	chr8	20214901	20214901	+	C	C	T	Silent	SNP	ENST00000276390.7	exon10	c.C1011T	p.R337R	exonic	ENSG00000147416.11	.	synonymous SNV	ENSG00000147416.11:ENST00000276390.7:exon10:c.C1011T:p.R337R	8p21.3	C3N-03666	8.246e-06	0	0	0	0	1.499e-05	0	0	rs550598553	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP6V1B2	139	0	316	28	0.0813953488372093	TRUE	NA
ENSG00000197140.15	.	BCM	GRCh38.p13	chr8	39254446	39254446	+	G	G	A	Silent	SNP	ENST00000379907.9	exon18	c.G1935A	p.S645S	exonic	ENSG00000197140.15	.	synonymous SNV	ENSG00000197140.15:ENST00000379907.9:exon18:c.G1935A:p.S645S	8p11.22	C3N-03666	0.0008	0.0030	0.0042	0	0	0.0002	0.0020	0.0007	rs113063036	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAM32	197	0	386	36	0.0853080568720379	TRUE	NA
ENSG00000204291.11	.	BCM	GRCh38.p13	chr9	99056338	99056338	+	A	A	C	Silent	SNP	ENST00000375001.8	exon35	c.A3271C	p.R1091R	exonic	ENSG00000204291.11	.	synonymous SNV	ENSG00000204291.11:ENST00000375001.8:exon35:c.A3271C:p.R1091R	9q22.33	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL15A1	268	0	345	28	0.0750670241286863	TRUE	TRUE
ENSG00000060237.17	.	BCM	GRCh38.p13	chr12	885103	885103	+	C	C	T	Silent	SNP	ENST00000315939.11	exon19	c.C4299T	p.V1433V	exonic	ENSG00000060237.17	.	synonymous SNV	ENSG00000060237.17:ENST00000315939.11:exon19:c.C4299T:p.V1433V	12p13.33	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WNK1	272	0	379	43	0.101895734597156	TRUE	TRUE
ENSG00000130037.5	.	BCM	GRCh38.p13	chr12	5045158	5045158	+	C	C	T	Silent	SNP	ENST00000252321.5	exon1	c.C1011T	p.F337F	exonic	ENSG00000130037.5	.	synonymous SNV	ENSG00000130037.5:ENST00000252321.5:exon1:c.C1011T:p.F337F	12p13.32	C3N-03666	.	.	.	.	.	.	.	.	rs977096843	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52904223;OCCURENCE=2(large_intestine)	KCNA5	269	0	378	36	0.0869565217391304	TRUE	TRUE
ENSG00000136160.17	.	BCM	GRCh38.p13	chr13	77918544	77918544	+	G	G	A	Silent	SNP	ENST00000646607.2	exon1	c.C30T	p.R10R	exonic	ENSG00000136160.17	.	synonymous SNV	ENSG00000136160.17:ENST00000646607.2:exon1:c.C30T:p.R10R	13q22.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV104636194;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	EDNRB	62	0	115	15	0.115384615384615	TRUE	NA
ENSG00000152749.8	.	BCM	GRCh38.p13	chr13	94623285	94623285	+	C	C	T	Silent	SNP	ENST00000376958.5	exon7	c.C1071T	p.Y357Y	exonic	ENSG00000152749.8	.	synonymous SNV	ENSG00000152749.8:ENST00000376958.5:exon7:c.C1071T:p.Y357Y	13q32.1	C3N-03666	8.251e-06	0	8.639e-05	0	0	0	0	0	rs565290535	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPR180	54	0	115	9	0.0725806451612903	TRUE	NA
ENSG00000059145.19	.	BCM	GRCh38.p13	chr16	1399436	1399436	+	A	A	G	Silent	SNP	ENST00000389221.9	exon5	c.T672C	p.Y224Y	exonic	ENSG00000059145.19	.	synonymous SNV	ENSG00000059145.19:ENST00000389221.9:exon5:c.T672C:p.Y224Y	16p13.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UNKL	224	0	300	59	0.164345403899721	TRUE	TRUE
ENSG00000237515.9	.	BCM	GRCh38.p13	chr16	12902562	12902562	+	C	C	T	Silent	SNP	ENST00000558583.3	exon1	c.C498T	p.L166L	exonic	ENSG00000237515.9	.	synonymous SNV	ENSG00000237515.9:ENST00000558583.3:exon1:c.C498T:p.L166L	16p13.12	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SHISA9	151	0	239	25	0.0946969696969697	TRUE	TRUE
ENSG00000179776.19	.	BCM	GRCh38.p13	chr16	66390422	66390422	+	G	G	A	Silent	SNP	ENST00000341529.8	exon6	c.G801A	p.V267V	exonic	ENSG00000179776.19	.	synonymous SNV	ENSG00000179776.19:ENST00000341529.8:exon6:c.G801A:p.V267V	16q21	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDH5	77	0	117	36	0.235294117647059	TRUE	TRUE
ENSG00000197879.17	.	BCM	GRCh38.p13	chr17	1470205	1470205	+	C	C	T	Silent	SNP	ENST00000648651.1	exon24	c.G2496A	p.S832S	exonic	ENSG00000197879.17	.	synonymous SNV	ENSG00000197879.17:ENST00000648651.1:exon24:c.G2496A:p.S832S	17p13.3	C3N-03666	1.879e-05	0	9.334e-05	0	0	1.694e-05	0	0	rs778562822	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO1C	69	0	82	13	0.136842105263158	TRUE	NA
ENSG00000262664.3	.	BCM	GRCh38.p13	chr17	2042161	2042161	+	G	G	A	Silent	SNP	ENST00000572195.3	exon1	c.G114A	p.E38E	exonic	ENSG00000262664.3	.	synonymous SNV	ENSG00000262664.3:ENST00000572195.3:exon1:c.G114A:p.E38E	17p13.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OVCA2	102	0	142	15	0.0955414012738854	TRUE	TRUE
ENSG00000214978.7	.	BCM	GRCh38.p13	chr17	9802503	9802503	+	G	G	A	Silent	SNP	ENST00000399363.4	exon5	c.C765T	p.P255P	exonic	ENSG00000214978.7	.	synonymous SNV	ENSG00000214978.7:ENST00000399363.4:exon5:c.C765T:p.P255P	17p13.1	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GSG1L2	183	0	264	33	0.111111111111111	TRUE	NA
ENSG00000105556.11	.	BCM	GRCh38.p13	chr19	307250	307250	+	C	C	T	Silent	SNP	ENST00000264819.6	exon13	c.G1485A	p.E495E	exonic	ENSG00000105556.11	.	synonymous SNV	ENSG00000105556.11:ENST00000264819.6:exon13:c.G1485A:p.E495E	19p13.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIER2	433	0	510	67	0.116117850953206	TRUE	TRUE
ENSG00000012124.17	.	BCM	GRCh38.p13	chr19	35341407	35341407	+	G	G	A	Silent	SNP	ENST00000085219.10	exon8	c.G1572A	p.S524S	exonic	ENSG00000012124.17	.	synonymous SNV	ENSG00000012124.17:ENST00000085219.10:exon8:c.G1572A:p.S524S	19q13.12	C3N-03666	8.313e-06	0	0	0	0	0	0	6.067e-05	rs759785914	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50070972;OCCURENCE=1(skin)	CD22	220	0	377	30	0.0737100737100737	TRUE	TRUE
ENSG00000105467.9	.	BCM	GRCh38.p13	chr19	48375650	48375650	+	C	C	T	Silent	SNP	ENST00000344846.7	exon4	c.C369T	p.F123F	exonic	ENSG00000105467.9	.	synonymous SNV	ENSG00000105467.9:ENST00000344846.7:exon4:c.C369T:p.F123F	19q13.33	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61225315;OCCURENCE=2(skin)	SYNGR4	99	0	176	19	0.0974358974358974	TRUE	TRUE
ENSG00000153779.11	.	BCM	GRCh38.p13	chrX	89922652	89922652	+	G	G	A	Silent	SNP	ENST00000283891.6	exon2	c.G567A	p.P189P	exonic	ENSG00000153779.11	.	synonymous SNV	ENSG00000153779.11:ENST00000283891.6:exon2:c.G567A:p.P189P	Xq21.31	C3N-03666	.	.	.	.	.	.	.	.	rs34232559	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99383208;OCCURENCE=1(skin),2(endometrium)	TGIF2LX	385	0	403	103	0.203557312252964	NA	TRUE
ENSG00000228400.2	.	BCM	GRCh38.p13	chr2	124014096	124014096	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000228400.2	.	.	.	2q14.3	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC079154.1	152	0	221	21	0.0867768595041322	TRUE	NA
ENSG00000158428.4	.	BCM	GRCh38.p13	chr2	218367965	218367965	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000158428.4	ENST00000289388.4:c.*1G>A	.	.	2q35	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CATIP	193	0	260	29	0.100346020761246	TRUE	NA
ENSG00000154175.17	.	BCM	GRCh38.p13	chr3	100816745	100816745	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000154175.17	.	.	.	3q12.2	C3N-03666	.	.	.	.	.	.	.	.	.	3.17	D	T	B	B	.	D	.	T	N	0.162	T	T	T	0.017	.	0.268	.	.	T	T	T	T	D	1.801	17.740	0.999	N	N	-0.352	1.491	-0.275	1.617	0.701	0.693	0.574	0.574	0.564	.	4.960	4.090	1.566	1.176	0.676	0.016	0.987	0.985	688	.	.	.	.	ABI3BP	276	1	589	31	0.05	TRUE	NA
ENSG00000198788.8	.	BCM	GRCh38.p13	chr11	1103916	1103916	+	C	C	G	3'Flank	SNP	NA	NA	NA	NA	downstream	ENSG00000198788.8	dist=460	.	.	11p15.5	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC2	261	0	352	27	0.0712401055408971	TRUE	NA
ENSG00000149499.11	.	BCM	GRCh38.p13	chr11	62602448	62602448	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000149499.11	ENST00000394773.6:c.*27C>T	.	.	11q12.3	C3N-03666	.	.	.	.	.	.	.	.	rs1047866726	2.17	D	D	B	B	.	N	.	T	N	0.116	T	T	T	0.025	0.396	0.088	.	.	T	T	T	T	T	1.541	16.000	0.861	N	N	-1.279	0.177	-1.355	0.176	1.000	0.628	0.672	0.504	0.373	.	3.400	-1.950	-0.105	-1.339	-1.766	0.001	0.000	0.000	177	.	.	.	.	EML3	130	0	156	14	0.0823529411764706	TRUE	NA
ENSG00000229807.12	.	BCM	GRCh38.p13	chrX	73845776	73845776	+	-	NA	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000229807.12	.	.	.	Xq13.2	C3N-03666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	XIST	NA	NA	NA	NA	NA	NA	NA
ENSG00000134744.14	.	BCM	GRCh38.p13	chr1	52461542	52461542	+	C	C	T	Missense_Mutation	SNP	ENST00000371544.7	exon18	c.G3202A	p.E1068K	exonic	ENSG00000134744.14	.	nonsynonymous SNV	ENSG00000134744.14:ENST00000371544.7:exon18:c.G3202A:p.E1068K	1p32.3	C3N-04126	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	H	T	D	0.687	T	T	D	0.552	0.378	0.832	2.647	D	T	D	D	D	D	4.009	27.000	0.999	D	D	0.963	12.783	0.918	14.560	1.000	0.732	0.744	0.710	0.728	.	5.810	5.810	7.542	1.026	0.599	1.000	0.998	0.996	314	.	.	.	.	TUT4	219	0	213	19	0.0818965517241379	TRUE	TRUE
ENSG00000162627.17	.	BCM	GRCh38.p13	chr1	98698754	98698754	+	C	C	T	Missense_Mutation	SNP	ENST00000306121.8	exon6	c.C887T	p.S296L	exonic	ENSG00000162627.17	.	nonsynonymous SNV	ENSG00000162627.17:ENST00000306121.8:exon6:c.C887T:p.S296L	1p21.3	C3N-04126	.	.	.	.	.	.	.	.	.	11.19	D	D	D	P	D	D	.	T	D	0.671	T	T	D	0.132	0.397	0.771	0.283	T	T	T	T	D	D	3.939	26.600	0.998	D	D	0.603	5.958	0.608	6.324	1.000	0.707	0.588	0.659	0.714	.	5.280	5.280	4.422	1.026	0.599	1.000	0.995	0.966	911	Phox_homologous_domain	.	.	.	SNX7	300	0	280	50	0.151515151515152	NA	TRUE
ENSG00000143612.20	.	BCM	GRCh38.p13	chr1	154219861	154219861	+	A	A	G	Missense_Mutation	SNP	ENST00000368521.9	exon2	c.T143C	p.V48A	exonic	ENSG00000143612.20	.	nonsynonymous SNV	ENSG00000143612.20:ENST00000368521.9:exon2:c.T143C:p.V48A	1q21.3	C3N-04126	.	.	.	.	.	.	.	.	.	5.18	T	T	B	B	D	D	L	.	N	0.379	T	T	T	0.125	0.721	0.327	0.429	.	T	T	T	D	T	2.956	23.300	0.995	D	D	0.102	2.894	0.308	3.764	1.000	0.543	0.522	0.686	0.562	.	6.170	6.170	5.849	1.312	0.756	1.000	1.000	1.000	73	.	.	.	.	C1orf43	262	0	255	29	0.102112676056338	TRUE	TRUE
ENSG00000143801.17	.	BCM	GRCh38.p13	chr1	226895529	226895529	+	C	C	G	Missense_Mutation	SNP	ENST00000366783.8	exon13	c.C1297G	p.L433V	exonic	ENSG00000143801.17	.	nonsynonymous SNV	ENSG00000143801.17:ENST00000366783.8:exon13:c.C1297G:p.L433V	1q42.13	C3N-04126	.	.	.	.	.	.	.	.	.	13.20	T	T	P	B	D	D	L	D	N	0.475	D	D	D	0.644	0.762	0.960	0.419	T	D	D	D	D	D	1.905	18.530	0.996	D	D	-0.007	2.488	0.127	2.846	0.930	0.732	0.709	0.744	0.636	.	5.970	5.060	2.582	-0.328	0.537	1.000	0.911	0.935	790	.	.	.	.	PSEN2	399	0	436	68	0.134920634920635	TRUE	TRUE
ENSG00000071575.11	.	BCM	GRCh38.p13	chr2	12740346	12740346	+	G	G	T	Missense_Mutation	SNP	ENST00000155926.8	exon3	c.G584T	p.S195I	exonic	ENSG00000071575.11	.	nonsynonymous SNV	ENSG00000071575.11:ENST00000155926.8:exon3:c.G584T:p.S195I	2p24.3	C3N-04126	.	.	.	.	.	.	.	.	.	12.20	D	D	P	P	D	D	L	T	D	0.847	T	T	D	0.595	0.660	0.595	1.882	T	T	D	D	D	D	4.128	28.000	0.997	D	D	0.724	7.463	0.772	9.354	1.000	0.707	0.546	0.702	0.714	.	5.930	5.930	8.010	1.176	0.676	1.000	0.999	0.998	961	Protein_kinase_domain	.	.	.	TRIB2	234	0	220	14	0.0598290598290598	TRUE	TRUE
ENSG00000168542.16	.	BCM	GRCh38.p13	chr2	188999570	188999570	+	G	G	A	Missense_Mutation	SNP	ENST00000304636.9	exon31	c.G2222A	p.G741D	exonic	ENSG00000168542.16	.	nonsynonymous SNV	ENSG00000168542.16:ENST00000304636.9:exon31:c.G2222A:p.G741D	2q32.2	C3N-04126	8.333e-06	9.99e-05	0	0	0	0	0	0	rs553203474	20.20	D	D	D	D	D	D	H	D	D	0.991	D	D	D	0.999	0.987	0.992	0.817	D	D	D	D	D	D	4.249	29.100	0.996	D	D	1.087	16.964	0.990	18.258	1.000	0.554	0.574	0.618	0.621	.	5.350	5.350	9.953	1.176	0.676	1.000	0.994	0.946	839	.	.	.	.	COL3A1	499	0	491	64	0.115315315315315	TRUE	NA
ENSG00000144452.15	.	BCM	GRCh38.p13	chr2	214975957	214975957	+	A	A	G	Missense_Mutation	SNP	ENST00000272895.12	exon34	c.T5209C	p.F1737L	exonic	ENSG00000144452.15	.	nonsynonymous SNV	ENSG00000144452.15:ENST00000272895.12:exon34:c.T5209C:p.F1737L	2q35	C3N-04126	.	.	.	.	.	.	.	.	.	13.20	T	T	D	P	D	D	M	D	N	0.510	D	D	D	0.714	0.473	0.877	0.748	T	T	D	D	D	T	3.940	26.600	0.977	D	D	0.348	4.035	0.449	4.724	0.783	0.638	0.670	0.574	0.564	.	5.870	5.870	5.077	1.312	0.756	1.000	1.000	0.993	877	.	.	.	.	ABCA12	320	0	305	66	0.177897574123989	TRUE	TRUE
ENSG00000163501.7	.	BCM	GRCh38.p13	chr2	219055397	219055397	+	G	G	A	Missense_Mutation	SNP	ENST00000295731.7	exon3	c.C1046T	p.A349V	exonic	ENSG00000163501.7	.	nonsynonymous SNV	ENSG00000163501.7:ENST00000295731.7:exon3:c.C1046T:p.A349V	2q35	C3N-04126	2.541e-05	0.0001	0	0	0	3.106e-05	0	0	rs777059543	19.20	D	D	D	D	D	D	M	D	D	0.953	D	D	D	0.955	0.864	0.970	0.792	T	D	D	D	D	D	3.723	25.500	0.999	D	D	0.934	11.956	0.847	11.660	1.000	0.549	0.590	0.590	0.542	.	5.160	5.160	9.907	1.176	0.676	1.000	0.458	0.246	516	Hint_domain_C-terminal;Hedgehog_protein,_Hint_domain	.	.	ID=COSV104603443;OCCURENCE=1(central_nervous_system)	IHH	227	0	227	34	0.130268199233716	TRUE	NA
ENSG00000163516.14	.	BCM	GRCh38.p13	chr2	219232592	219232592	+	G	G	A	Missense_Mutation	SNP	ENST00000323348.10	exon5	c.G467A	p.R156Q	exonic	ENSG00000163516.14	.	nonsynonymous SNV	ENSG00000163516.14:ENST00000323348.10:exon5:c.G467A:p.R156Q	2q35	C3N-04126	3.313e-05	0.0001	0	0	0	2.998e-05	0	6.057e-05	rs373389031	0.20	T	T	B	B	N	N	L	T	N	0.108	T	T	T	0.028	.	0.278	0.128	T	T	T	T	T	T	0.357	4.942	0.598	N	N	-1.674	0.041	-1.702	0.051	1.000	0.719	0.725	0.725	0.734	.	5.530	-2.870	0.399	-0.565	-0.802	0.000	0.000	0.000	550	.	.	.	.	ANKZF1	386	0	431	53	0.109504132231405	TRUE	NA
ENSG00000174738.13	.	BCM	GRCh38.p13	chr3	23977267	23977267	+	G	G	A	Missense_Mutation	SNP	ENST00000312521.9	exon8	c.G1588A	p.E530K	exonic	ENSG00000174738.13	.	nonsynonymous SNV	ENSG00000174738.13:ENST00000312521.9:exon8:c.G1588A:p.E530K	3p24.2	C3N-04126	.	.	.	.	.	.	.	.	.	16.16	D	D	.	.	D	D	.	D	D	0.665	D	D	D	0.827	0.679	0.801	0.838	D	.	D	D	D	D	4.294	29.500	0.999	D	D	0.985	13.467	0.957	16.403	1.000	0.732	0.634	0.725	0.728	.	5.920	5.920	9.968	1.176	0.676	1.000	0.998	0.942	527	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	NR1D2	97	0	107	20	0.15748031496063	TRUE	TRUE
ENSG00000114480.13	.	BCM	GRCh38.p13	chr3	81536991	81536991	+	G	G	A	Missense_Mutation	SNP	ENST00000429644.7	exon13	c.C1723T	p.L575F	exonic	ENSG00000114480.13	.	nonsynonymous SNV	ENSG00000114480.13:ENST00000429644.7:exon13:c.C1723T:p.L575F	3p12.2	C3N-04126	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	H	T	D	0.827	T	T	D	0.619	0.763	0.661	0.246	T	D	D	D	D	D	4.156	28.200	0.999	D	D	1.134	19.125	1.024	20.401	1.000	0.706	0.710	0.653	0.634	.	5.300	5.300	9.516	1.176	0.676	1.000	0.999	0.990	651	.	.	.	.	GBE1	240	0	222	55	0.1985559566787	TRUE	TRUE
ENSG00000070476.15	.	BCM	GRCh38.p13	chr3	126439640	126439640	+	C	C	T	Missense_Mutation	SNP	ENST00000389709.8	exon9	c.G2482A	p.V828I	exonic	ENSG00000070476.15	.	nonsynonymous SNV	ENSG00000070476.15:ENST00000389709.8:exon9:c.G2482A:p.V828I	3q21.3	C3N-04126	.	.	.	.	.	.	.	.	rs1027630984	0.20	T	T	B	B	N	N	N	T	N	0.137	T	T	T	0.044	.	0.122	0.080	T	T	T	T	T	T	1.153	13.250	0.902	N	N	-0.880	0.545	-0.754	0.823	1.000	0.706	0.577	0.710	0.636	.	4.370	1.600	1.221	0.070	-0.266	0.991	0.977	0.773	854	.	.	.	.	ZXDC	475	1	562	105	0.157421289355322	TRUE	NA
ENSG00000178950.17	.	BCM	GRCh38.p13	chr4	932060	932060	+	C	C	A	Missense_Mutation	SNP	ENST00000314167.9	exon1	c.G128T	p.R43L	exonic	ENSG00000178950.17	.	nonsynonymous SNV	ENSG00000178950.17:ENST00000314167.9:exon1:c.G128T:p.R43L	4p16.3	C3N-04126	.	.	.	.	.	.	.	.	.	12.20	D	D	P	P	D	D	N	D	D	0.504	T	T	D	0.453	0.573	0.713	2.676	D	T	T	T	D	D	4.187	28.500	0.995	D	D	0.096	2.871	0.143	2.917	1.000	0.733	0.522	0.601	0.373	.	4.650	2.570	2.342	1.010	0.580	1.000	1.000	0.989	789	Protein_kinase_domain	.	.	.	GAK	654	1	689	124	0.152521525215252	TRUE	TRUE
ENSG00000137449.16	.	BCM	GRCh38.p13	chr4	15003131	15003131	+	C	C	G	Missense_Mutation	SNP	ENST00000538197.6	exon1	c.C458G	p.S153C	exonic	ENSG00000137449.16	.	nonsynonymous SNV	ENSG00000137449.16:ENST00000538197.6:exon1:c.C458G:p.S153C	4p15.32	C3N-04126	.	.	.	.	.	.	.	.	.	2.14	D	T	.	.	.	N	.	T	N	0.377	T	T	D	0.046	0.169	0.171	0.309	T	.	T	T	T	.	2.449	22.300	0.947	N	N	-0.218	1.826	-0.203	1.779	1.000	0.623	0.166	0.378	0.250	.	2.860	2.860	0.696	0.016	0.429	0.025	0.997	0.997	592	.	.	.	.	CPEB2	86	0	127	14	0.099290780141844	TRUE	TRUE
ENSG00000150471.16	.	BCM	GRCh38.p13	chr4	61979758	61979758	+	C	C	T	Nonsense_Mutation	SNP	ENST00000506720.5	exon16	c.C3001T	p.R1001X	exonic	ENSG00000150471.16	.	stopgain	ENSG00000150471.16:ENST00000506720.5:exon16:c.C3001T:p.R1001X	4q13.1	C3N-04126	.	.	.	.	.	.	.	.	.	6.7	.	.	.	.	D	A	.	.	.	0.517	.	.	.	.	.	.	.	.	.	D	D	D	.	7.608	38	0.998	D	N	0.563	5.565	0.379	4.213	0.000	0.638	0.574	0.653	0.564	.	5.500	2.730	0.589	-0.361	0.549	0.993	0.948	0.841	953	GPCR,_family_2-like	.	.	ID=COSV72230261;OCCURENCE=1(stomach),1(lung)	ADGRL3	198	0	167	35	0.173267326732673	TRUE	TRUE
ENSG00000185803.11	.	BCM	GRCh38.p13	chr8	144360479	144360479	+	G	G	C	Missense_Mutation	SNP	ENST00000643944.2	exon3	c.G987C	p.M329I	exonic	ENSG00000185803.11	.	nonsynonymous SNV	ENSG00000185803.11:ENST00000643944.2:exon3:c.G987C:p.M329I	8q24.3	C3N-04126	.	.	.	.	.	.	.	.	.	11.19	D	D	B	B	D	D	M	T	D	0.666	T	T	D	0.453	0.703	0.698	0.287	T	T	D	T	D	.	3.440	24.500	0.988	D	D	0.332	3.951	0.421	4.513	1.000	0.672	0.698	0.723	0.711	.	4.690	4.690	9.483	1.176	0.676	1.000	0.984	0.996	940	.	.	.	.	SLC52A2	139	0	161	36	0.182741116751269	TRUE	TRUE
ENSG00000107614.22	.	BCM	GRCh38.p13	chr10	17157645	17157645	+	A	A	C	Missense_Mutation	SNP	ENST00000377799.8	exon8	c.T683G	p.I228S	exonic	ENSG00000107614.22	.	nonsynonymous SNV	ENSG00000107614.22:ENST00000377799.8:exon8:c.T683G:p.I228S	10p13	C3N-04126	.	.	.	.	.	.	.	.	.	7.20	D	T	P	P	N	D	L	T	N	0.447	T	T	T	0.136	0.520	0.790	0.018	T	D	T	T	D	D	3.583	25.000	0.994	D	D	0.219	3.390	0.362	4.099	1.000	0.706	0.670	0.710	0.655	.	5.410	5.410	7.631	1.311	0.756	1.000	0.999	0.997	777	.	.	.	.	TRDMT1	313	0	247	43	0.148275862068966	TRUE	TRUE
ENSG00000108231.13	.	BCM	GRCh38.p13	chr10	93758813	93758813	+	C	C	T	Missense_Mutation	SNP	ENST00000371418.9	exon2	c.C269T	p.T90M	exonic	ENSG00000108231.13	.	nonsynonymous SNV	ENSG00000108231.13:ENST00000371418.9:exon2:c.C269T:p.T90M	10q23.33	C3N-04126	.	.	.	.	.	.	.	.	rs796052692	9.20	T	T	D	P	D	D	N	D	N	0.683	D	D	D	0.394	0.634	0.685	0.956	T	T	T	T	T	D	2.382	22.000	0.995	D	N	0.116	2.949	0.275	3.575	1.000	0.447	0.563	0.507	0.530	.	5.020	5.020	5.097	0.128	0.599	1.000	0.995	0.998	189	.	.	.	.	LGI1	451	2	444	49	0.0993914807302231	TRUE	NA
ENSG00000110719.10	.	BCM	GRCh38.p13	chr11	68050592	68050592	+	C	C	G	Missense_Mutation	SNP	ENST00000265686.8	exon19	c.C2342G	p.A781G	exonic	ENSG00000110719.10	.	nonsynonymous SNV	ENSG00000110719.10:ENST00000265686.8:exon19:c.C2342G:p.A781G	11q13.2	C3N-04126	.	.	.	.	.	.	.	.	.	18.20	D	T	D	D	D	D	M	D	D	0.790	D	D	D	0.733	0.771	0.948	0.662	T	D	D	D	D	D	3.328	24.200	0.995	D	D	0.505	5.071	0.397	4.341	1.000	0.672	0.702	0.723	0.711	.	4.060	4.060	7.758	0.962	0.524	1.000	0.004	0.002	788	.	.	.	.	TCIRG1	799	1	785	104	0.116985376827897	TRUE	TRUE
ENSG00000165323.15	.	BCM	GRCh38.p13	chr11	92790199	92790199	+	A	A	T	Missense_Mutation	SNP	ENST00000409404.6	exon7	c.A4592T	p.K1531M	exonic	ENSG00000165323.15	.	nonsynonymous SNV	ENSG00000165323.15:ENST00000409404.6:exon7:c.A4592T:p.K1531M	11q14.3	C3N-04126	.	.	.	.	.	.	.	.	.	4.15	D	.	.	.	.	D	L	T	N	0.687	T	T	T	0.202	0.531	0.165	.	T	T	T	T	D	.	3.170	23.800	0.995	D	N	0.440	4.601	0.472	4.910	0.991	0.615	0.590	0.659	0.621	.	6.170	5.050	3.733	1.312	0.756	1.000	1.000	1.000	906	Cadherin-like	.	.	.	FAT3	164	0	167	24	0.12565445026178	TRUE	TRUE
ENSG00000187240.16	.	BCM	GRCh38.p13	chr11	103156571	103156571	+	C	C	T	Nonsense_Mutation	SNP	ENST00000375735.7	exon26	c.C3928T	p.Q1310X	exonic	ENSG00000187240.16	.	stopgain	ENSG00000187240.16:ENST00000375735.7:exon26:c.C3928T:p.Q1310X	11q22.3	C3N-04126	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.977	.	.	.	.	.	.	.	.	.	D	D	.	.	7.498	38	0.998	D	N	1.109	17.901	0.950	16.072	0.999	0.554	0.574	0.574	0.568	.	5.270	5.270	7.267	1.026	0.599	1.000	0.996	0.990	512	Dynein_heavy_chain,_domain-2	.	.	ID=COSV100518488;OCCURENCE=1(endometrium)	DYNC2H1	520	0	464	58	0.111111111111111	TRUE	TRUE
ENSG00000204403.9	.	BCM	GRCh38.p13	chr11	104897312	104897312	+	G	G	C	Missense_Mutation	SNP	ENST00000422698.6	exon2	c.C164G	p.A55G	exonic	ENSG00000204403.9	.	nonsynonymous SNV	ENSG00000204403.9:ENST00000422698.6:exon2:c.C164G:p.A55G	11q22.3	C3N-04126	.	.	.	.	.	.	.	.	.	2.15	D	.	.	.	N	N	.	T	N	0.076	T	T	T	0.146	0.773	0.088	0.019	T	.	T	T	D	T	1.495	15.700	0.992	N	N	-0.236	1.779	-0.316	1.532	0.995	0.713	0.588	0.547	0.670	.	4.570	3.610	0.789	1.148	0.662	0.448	0.018	0.003	883	.	.	.	.	CASP12	193	0	185	17	0.0841584158415842	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-04126	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	391	0	367	80	0.178970917225951	TRUE	TRUE
ENSG00000169397.3	.	BCM	GRCh38.p13	chr14	20891849	20891849	+	C	C	T	Missense_Mutation	SNP	ENST00000304639.3	exon2	c.C163T	p.R55W	exonic	ENSG00000169397.3	.	nonsynonymous SNV	ENSG00000169397.3:ENST00000304639.3:exon2:c.C163T:p.R55W	14q11.2	C3N-04126	2.473e-05	9.694e-05	0.0002	0	0	0	0	0	rs115812876	8.20	D	D	D	D	U	N	M	T	D	0.229	T	D	T	0.313	.	0.678	0.285	T	T	T	T	D	T	1.020	11.870	0.997	N	N	-0.453	1.271	-0.812	0.741	0.970	0.487	0.590	0.574	0.542	.	2.560	-2.510	-3.277	0.049	0.529	0.000	0.103	0.019	867	Ribonuclease_A-domain	.	.	.	RNASE3	662	0	688	102	0.129113924050633	TRUE	TRUE
ENSG00000128731.18	.	BCM	GRCh38.p13	chr15	28293005	28293005	+	T	T	A	Missense_Mutation	SNP	ENST00000261609.13	exon4	c.A205T	p.S69C	exonic	ENSG00000128731.18	.	nonsynonymous SNV	ENSG00000128731.18:ENST00000261609.13:exon4:c.A205T:p.S69C	15q13.1	C3N-04126	.	.	.	.	.	.	.	.	.	3.19	T	.	B	B	N	D	L	T	N	0.400	T	T	T	0.050	0.260	0.284	0.155	T	T	T	T	D	T	2.176	20.700	0.088	D	N	-0.184	1.921	-0.083	2.096	0.977	0.732	0.709	0.710	0.728	.	4.700	4.700	3.514	0.113	0.586	1.000	0.746	0.842	840	.	.	.	.	HERC2	219	0	244	81	0.249230769230769	NA	TRUE
ENSG00000166747.12	.	BCM	GRCh38.p13	chr16	71748312	71748312	+	T	T	C	Missense_Mutation	SNP	ENST00000299980.8	exon16	c.A1564G	p.T522A	exonic	ENSG00000166747.12	.	nonsynonymous SNV	ENSG00000166747.12:ENST00000299980.8:exon16:c.A1564G:p.T522A	16q22.2	C3N-04126	8.277e-06	9.641e-05	0	0	0	0	0	0	rs555677572	15.20	D	D	D	D	D	D	M	T	D	0.940	T	T	D	0.565	.	0.711	0.331	D	T	T	D	D	D	4.023	27.100	0.998	D	D	0.809	8.957	0.744	8.661	1.000	0.732	0.725	0.744	0.714	.	4.900	4.900	7.670	1.138	0.665	1.000	1.000	1.000	64	Clathrin/coatomer_adaptor,_adaptin-like,_N-terminal	.	.	.	AP1G1	313	0	332	27	0.0752089136490251	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7676257	7676257	+	G	G	A	Nonsense_Mutation	SNP	ENST00000269305.8	exon4	c.C112T	p.Q38X	exonic	ENSG00000141510.17	.	stopgain	ENSG00000141510.17:ENST00000269305.8:exon4:c.C112T:p.Q38X	17p13.1	C3N-04126	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	U	A	.	.	.	0.805	.	.	.	.	.	.	.	.	.	D	D	.	.	4.536	32	0.978	N	N	-0.139	2.055	-0.549	1.124	0.115	0.722	0.702	0.699	0.735	.	3.410	-1.110	-1.439	0.847	0.672	0.000	0.003	0.027	434	.	.	.	ID=COSV52689258;OCCURENCE=3(oesophagus),1(haematopoietic_and_lymphoid_tissue),1(stomach),1(pancreas),1(prostate),6(lung),2(upper_aerodigestive_tract)	TP53	371	0	309	56	0.153424657534247	TRUE	TRUE
ENSG00000108510.10	.	BCM	GRCh38.p13	chr17	61983045	61983045	+	C	C	T	Missense_Mutation	SNP	ENST00000397786.7	exon16	c.G2958A	p.M986I	exonic	ENSG00000108510.10	.	nonsynonymous SNV	ENSG00000108510.10:ENST00000397786.7:exon16:c.G2958A:p.M986I	17q23.2	C3N-04126	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	D	D	N	T	N	0.580	T	T	T	0.297	0.098	0.522	0.482	T	T	D	T	T	D	2.641	22.700	0.995	D	N	0.246	3.513	0.414	4.461	1.000	0.707	0.725	0.725	0.714	.	6.030	6.030	3.857	1.026	0.599	1.000	1.000	0.998	125	.	.	.	.	MED13	230	0	244	45	0.155709342560554	TRUE	TRUE
ENSG00000141338.14	.	BCM	GRCh38.p13	chr17	68877520	68877520	+	G	G	A	Missense_Mutation	SNP	ENST00000586539.6	exon33	c.C4198T	p.R1400W	exonic	ENSG00000141338.14	.	nonsynonymous SNV	ENSG00000141338.14:ENST00000586539.6:exon33:c.C4198T:p.R1400W	17q24.2	C3N-04126	5.073e-05	0	0	0	0	7.584e-05	0	7.001e-05	rs768328938	11.20	D	D	D	D	N	N	L	D	D	0.632	D	D	D	0.486	.	0.832	0.102	T	T	T	D	T	T	2.941	23.300	0.997	N	D	-0.383	1.421	-0.683	0.924	0.000	0.554	0.574	0.574	0.568	.	4.340	-4.130	-0.170	-0.269	0.665	0.001	0.020	0.075	977	ABC_transporter-like;AAA+_ATPase_domain	.	.	ID=COSV52204487;OCCURENCE=1(stomach)	ABCA8	130	0	154	17	0.0994152046783626	TRUE	TRUE
ENSG00000087460.25	.	BCM	GRCh38.p13	chr20	58909365	58909365	+	C	C	T	Missense_Mutation	SNP	ENST00000371100.8	exon8	c.C2530T	p.R844C	exonic	ENSG00000087460.25	.	nonsynonymous SNV	ENSG00000087460.25:ENST00000371100.8:exon8:c.C2530T:p.R844C	20q13.32	C3N-04126	8.238e-06	0	8.64e-05	0	0	0	0	0	rs11554273	20.20	D	D	D	D	D	D	H	D	D	0.887	D	D	D	0.943	0.913	0.997	3.743	D	D	D	D	D	D	4.600	32	0.999	D	D	0.934	11.959	0.815	10.570	1.000	0.722	0.699	0.702	0.735	.	5.530	4.530	4.121	1.026	0.599	1.000	0.910	0.934	987	.	.	.	ID=COSV55670339;OCCURENCE=8(breast),5(parathyroid),12(liver),18(peritoneum),2(oesophagus),20(adrenal_gland),9(cervix),84(large_intestine),9(biliary_tract),17(ovary),83(bone),3(NS),3(haematopoietic_and_lymphoid_tissue),32(stomach),3(kidney),26(soft_tissue),265(pancreas),1(autonomic_ganglia),167(pituitary),2(skin),1(prostate),4(lung),8(thyroid),1(upper_aerodigestive_tract),2(testis),34(small_intestine)	GNAS	976	1	941	129	0.120560747663551	NA	TRUE
ENSG00000099960.13	.	BCM	GRCh38.p13	chr22	21030097	21030097	+	G	G	A	Missense_Mutation	SNP	ENST00000382932.3	exon3	c.C1237T	p.R413C	exonic	ENSG00000099960.13	.	nonsynonymous SNV	ENSG00000099960.13:ENST00000382932.3:exon3:c.C1237T:p.R413C	22q11.21	C3N-04126	4.524e-05	0	0	0.0004	0	3.285e-05	0	0	rs371765676	19.20	D	D	D	D	D	D	H	D	D	0.973	D	D	D	0.845	.	0.971	0.296	T	D	D	D	D	D	4.343	29.900	0.999	D	D	0.978	13.234	0.842	11.500	1.000	0.581	0.547	0.576	0.564	.	5.460	5.460	6.201	1.176	0.676	1.000	0.994	0.986	596	.	.	.	.	SLC7A4	377	0	384	52	0.119266055045872	TRUE	NA
ENSG00000100243.21	.	BCM	GRCh38.p13	chr22	42627668	42627668	+	C	C	T	Missense_Mutation	SNP	ENST00000352397.10	exon6	c.G484A	p.D162N	exonic	ENSG00000100243.21	.	nonsynonymous SNV	ENSG00000100243.21:ENST00000352397.10:exon6:c.G484A:p.D162N	22q13.2	C3N-04126	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	N	D	L	D	D	0.316	T	T	D	0.275	0.398	0.879	0.127	T	T	T	T	D	D	3.525	24.800	0.972	D	D	-0.306	1.599	-0.279	1.607	1.000	0.732	0.702	0.744	0.714	.	4.760	1.530	4.996	1.026	0.599	1.000	0.987	0.834	264	.	.	.	.	CYB5R3	435	0	466	55	0.105566218809981	TRUE	TRUE
ENSG00000048707.15	.	BCM	GRCh38.p13	chr1	12327796	12327796	+	C	C	T	Silent	SNP	ENST00000620676.6	exon36	c.C8139T	p.I2713I	exonic	ENSG00000048707.15	.	synonymous SNV	ENSG00000048707.15:ENST00000620676.6:exon36:c.C8139T:p.I2713I	1p36.22	C3N-04126	8.237e-06	0	0	0	0	0	0	6.056e-05	rs752121874	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VPS13D	527	0	537	70	0.115321252059308	TRUE	NA
ENSG00000196171.3	.	BCM	GRCh38.p13	chr1	158700608	158700608	+	G	G	A	Silent	SNP	ENST00000359610.3	exon1	c.C45T	p.S15S	exonic	ENSG00000196171.3	.	synonymous SNV	ENSG00000196171.3:ENST00000359610.3:exon1:c.C45T:p.S15S	1q23.1	C3N-04126	.	.	.	.	.	.	.	.	rs929760142	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100656709;OCCURENCE=1(large_intestine)	OR6K2	175	0	131	21	0.138157894736842	TRUE	NA
ENSG00000173376.14	.	BCM	GRCh38.p13	chr4	121036471	121036471	+	T	T	C	Silent	SNP	ENST00000379692.9	exon4	c.A1500G	p.Q500Q	exonic	ENSG00000173376.14	.	synonymous SNV	ENSG00000173376.14:ENST00000379692.9:exon4:c.A1500G:p.Q500Q	4q27	C3N-04126	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NDNF	464	0	437	64	0.127744510978044	TRUE	TRUE
ENSG00000086570.12	.	BCM	GRCh38.p13	chr5	151531657	151531657	+	G	G	A	Silent	SNP	ENST00000261800.5	exon13	c.C9741T	p.G3247G	exonic	ENSG00000086570.12	.	synonymous SNV	ENSG00000086570.12:ENST00000261800.5:exon13:c.C9741T:p.G3247G	5q33.1	C3N-04126	2.521e-05	0	8.721e-05	0	0	0	0	0.0001	rs772008822	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAT2	639	0	571	105	0.155325443786982	TRUE	NA
ENSG00000128591.15	.	BCM	GRCh38.p13	chr7	128841204	128841204	+	C	C	T	Silent	SNP	ENST00000325888.12	exon12	c.C1848T	p.I616I	exonic	ENSG00000128591.15	.	synonymous SNV	ENSG00000128591.15:ENST00000325888.12:exon12:c.C1848T:p.I616I	7q32.1	C3N-04126	2.488e-05	0	0	0	0	1.502e-05	0	0.0001	rs770173704	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FLNC	192	0	157	33	0.173684210526316	TRUE	NA
ENSG00000167916.5	.	BCM	GRCh38.p13	chr17	40700121	40700121	+	G	G	A	Silent	SNP	ENST00000264651.3	exon5	c.C1020T	p.S340S	exonic	ENSG00000167916.5	.	synonymous SNV	ENSG00000167916.5:ENST00000264651.3:exon5:c.C1020T:p.S340S	17q21.2	C3N-04126	1.647e-05	0	0	0	0	2.997e-05	0	0	rs750253983	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KRT24	294	0	242	45	0.156794425087108	TRUE	NA
ENSG00000198858.10	.	BCM	GRCh38.p13	chr19	897461	897461	+	G	G	A	Silent	SNP	ENST00000361574.10	exon8	c.C783T	p.S261S	exonic	ENSG00000198858.10	.	synonymous SNV	ENSG00000198858.10:ENST00000361574.10:exon8:c.C783T:p.S261S	19p13.3	C3N-04126	7.246e-05	0.0006	0	0	0	1.866e-05	0	7.169e-05	rs375137933	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	R3HDM4	188	0	178	27	0.131707317073171	TRUE	NA
ENSG00000101203.16	.	BCM	GRCh38.p13	chr20	63307548	63307548	+	C	C	T	Silent	SNP	ENST00000358894.10	exon6	c.C555T	p.D185D	exonic	ENSG00000101203.16	.	synonymous SNV	ENSG00000101203.16:ENST00000358894.10:exon6:c.C555T:p.D185D	20q13.33	C3N-04126	0.0001	0.0001	0	0.0001	0	4.629e-05	0.0012	0.0006	rs767672689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL20A1	243	0	250	39	0.134948096885813	TRUE	NA
ENSG00000143776.18	.	BCM	GRCh38.p13	chr1	227068668	227068668	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000143776.18	.	.	.	1q42.13	C3N-04126	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDC42BPA	105	0	72	7	0.0886075949367089	TRUE	TRUE
ENSG00000026652.15	.	BCM	GRCh38.p13	chr6	161144197	161144197	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000026652.15	.	.	.	6q26	C3N-04126	.	.	.	.	.	.	.	.	rs938734659	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AGPAT4	294	1	284	40	0.123456790123457	TRUE	NA
ENSG00000236827.1	.	BCM	GRCh38.p13	chr8	11247648	11247648	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000236827.1	.	.	.	8p23.1	C3N-04126	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC00529	99	0	96	19	0.165217391304348	TRUE	NA
ENSG00000167604.14	.	BCM	GRCh38.p13	chr19	35890577	35890577	+	C	C	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000167604.14	.	.	.	19q13.12	C3N-04126	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NFKBID	469	0	553	64	0.103727714748784	TRUE	NA
ENSG00000168843.14	.	BCM	GRCh38.p13	chr4	161775960	161775961	+	CG	CG	AA	Unknown	MNP	ENST00000306100.10	exon5	c.523_524delinsTT	p.R175L	exonic	ENSG00000168843.14	.	nonframeshift substitution	ENSG00000168843.14:ENST00000306100.10:exon5:c.523_524delinsTT:p.R175L	4q32.2	C3N-04126	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FSTL5	219	0	191	11	0.0544554455445545	TRUE	TRUE
ENSG00000084636.18	.	BCM	GRCh38.p13	chr1	31683232	31683232	+	G	G	A	Missense_Mutation	SNP	ENST00000373672.8	exon36	c.C2431T	p.R811W	exonic	ENSG00000084636.18	.	nonsynonymous SNV	ENSG00000084636.18:ENST00000373672.8:exon36:c.C2431T:p.R811W	1p35.2	C3L-00017	2.485e-05	0.0001	0	0.0001	0	1.499e-05	0	0	rs376617047	16.20	D	D	D	P	N	D	M	D	D	0.409	D	D	D	0.601	.	0.923	0.163	T	D	T	D	D	D	4.446	32	0.997	D	D	0.790	8.596	0.758	8.984	1.000	0.615	0.610	0.659	0.568	.	5.530	5.530	4.931	1.176	0.676	1.000	0.871	0.350	749	.	.	.	.	COL16A1	220	0	361	65	0.152582159624413	TRUE	NA
ENSG00000006555.11	.	BCM	GRCh38.p13	chr1	54781419	54781419	+	G	G	A	Missense_Mutation	SNP	ENST00000371276.9	exon7	c.C1534T	p.R512C	exonic	ENSG00000006555.11	.	nonsynonymous SNV	ENSG00000006555.11:ENST00000371276.9:exon7:c.C1534T:p.R512C	1p32.3	C3L-00017	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	N	0.076	T	T	D	0.018	0.334	0.300	0.387	D	T	T	T	T	T	2.226	21.100	0.998	N	N	-0.666	0.871	-0.587	1.066	0.984	0.598	0.588	0.607	0.639	.	4.590	2.680	0.074	0.069	-0.306	0.000	0.991	0.978	923	.	.	.	.	TTC22	57	0	204	52	0.203125	TRUE	TRUE
ENSG00000196187.12	.	BCM	GRCh38.p13	chr1	225850043	225850043	+	C	C	T	Missense_Mutation	SNP	ENST00000366835.8	exon21	c.G1940A	p.R647Q	exonic	ENSG00000196187.12	.	nonsynonymous SNV	ENSG00000196187.12:ENST00000366835.8:exon21:c.G1940A:p.R647Q	1q42.12	C3L-00017	8.241e-06	0	0	0	0	1.499e-05	0	0	rs753018849	12.20	D	D	D	D	N	D	M	T	D	0.990	T	T	D	0.352	0.876	0.395	0.810	T	T	T	T	D	D	4.074	27.500	1.000	D	D	0.726	7.491	0.644	6.818	1.000	0.646	0.696	0.644	0.646	.	4.930	4.020	7.448	1.008	0.599	1.000	0.998	0.984	695	Calcium-dependent_channel,_7TM_region,_putative_phosphate	.	.	.	TMEM63A	168	0	352	45	0.113350125944584	TRUE	NA
ENSG00000155816.20	.	BCM	GRCh38.p13	chr1	240092440	240092440	+	G	G	A	Missense_Mutation	SNP	ENST00000319653.14	exon1	c.G331A	p.A111T	exonic	ENSG00000155816.20	.	nonsynonymous SNV	ENSG00000155816.20:ENST00000319653.14:exon1:c.G331A:p.A111T	1q43	C3L-00017	.	.	.	.	.	.	.	.	.	3.20	T	T	P	B	D	N	L	T	N	0.124	T	T	D	0.066	.	0.377	0.772	T	T	T	T	D	T	2.694	22.800	0.969	N	N	0.092	2.854	0.135	2.884	1.000	0.652	0.563	0.641	0.619	.	4.200	3.200	2.343	0.995	0.502	1.000	0.999	0.998	964	.	.	.	.	FMN2	203	0	335	195	0.367924528301887	TRUE	TRUE
ENSG00000115504.14	.	BCM	GRCh38.p13	chr2	63045147	63045147	+	C	C	T	Missense_Mutation	SNP	ENST00000263991.9	exon24	c.C3572T	p.A1191V	exonic	ENSG00000115504.14	.	nonsynonymous SNV	ENSG00000115504.14:ENST00000263991.9:exon24:c.C3572T:p.A1191V	2p15	C3L-00017	2.6e-05	0	0	0	0	5.062e-05	0	0	rs750441921	10.20	D	D	D	D	D	D	L	T	N	0.613	T	T	T	0.149	0.270	0.328	1.741	T	T	T	T	D	D	4.054	27.400	0.999	D	D	0.692	7.006	0.730	8.359	1.000	0.726	0.710	0.594	0.564	.	5.870	5.870	4.553	1.026	0.599	1.000	0.999	0.994	328	bMERB_domain	.	.	ID=COSV99859654;OCCURENCE=1(large_intestine)	EHBP1	113	0	227	35	0.133587786259542	TRUE	NA
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140982255	140982255	+	T	T	A	Missense_Mutation	SNP	ENST00000389484.8	exon18	c.A2792T	p.Q931L	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon18:c.A2792T:p.Q931L	2q22.1	C3L-00017	.	.	.	.	.	.	.	.	.	16.20	D	D	P	P	U	D	M	D	D	0.790	D	D	D	0.847	0.484	0.690	0.577	T	D	D	D	D	D	3.919	26.500	0.996	D	D	0.441	4.611	0.415	4.468	0.007	0.554	0.574	0.574	0.568	.	5.430	4.260	7.887	1.118	-0.147	1.000	0.998	0.994	603	.	.	.	.	LRP1B	210	0	316	28	0.0813953488372093	TRUE	TRUE
ENSG00000175084.12	.	BCM	GRCh38.p13	chr2	219418517	219418517	+	G	G	A	Missense_Mutation	SNP	ENST00000373960.4	exon1	c.G55A	p.G19S	exonic	ENSG00000175084.12	.	nonsynonymous SNV	ENSG00000175084.12:ENST00000373960.4:exon1:c.G55A:p.G19S	2q35	C3L-00017	.	.	.	.	.	.	.	.	.	18.20	T	D	D	D	D	D	M	D	D	0.582	D	D	D	0.738	0.754	0.954	0.897	T	D	D	D	D	D	4.067	27.500	0.994	D	D	0.709	7.241	0.678	7.364	1.000	0.598	0.590	0.596	0.639	.	5.120	5.120	6.722	1.092	0.590	1.000	0.994	0.983	86	Intermediate_filament_head,_DNA-binding_domain	.	.	.	DES	90	0	235	32	0.119850187265918	TRUE	TRUE
ENSG00000163082.10	.	BCM	GRCh38.p13	chr2	222558869	222558869	+	A	A	G	Missense_Mutation	SNP	ENST00000321276.8	exon5	c.A1171G	p.M391V	exonic	ENSG00000163082.10	.	nonsynonymous SNV	ENSG00000163082.10:ENST00000321276.8:exon5:c.A1171G:p.M391V	2q36.1	C3L-00017	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	D	N	L	.	N	0.106	T	T	T	0.064	0.289	0.261	0.127	T	T	T	T	D	T	1.368	14.870	0.930	D	N	-0.301	1.612	-0.178	1.839	0.008	0.672	0.702	0.564	0.568	.	5.510	4.290	1.067	1.312	0.756	0.456	0.939	0.895	930	.	.	.	.	SGPP2	114	0	105	28	0.210526315789474	TRUE	TRUE
ENSG00000114853.14	.	BCM	GRCh38.p13	chr3	42659416	42659416	+	A	A	G	Missense_Mutation	SNP	ENST00000232974.11	exon2	c.A1061G	p.E354G	exonic	ENSG00000114853.14	.	nonsynonymous SNV	ENSG00000114853.14:ENST00000232974.11:exon2:c.A1061G:p.E354G	3p22.1	C3L-00017	.	.	.	.	.	.	.	.	rs899087761	3.16	D	T	.	.	.	N	N	T	N	0.092	T	T	D	0.033	.	0.117	0.484	T	T	T	T	T	T	1.019	11.860	0.851	D	.	-0.797	0.660	-0.869	0.662	1.000	0.615	0.634	0.576	0.492	.	3.990	-0.120	1.182	0.251	-0.122	0.704	0.018	0.012	365	.	.	.	.	ZBTB47	12	1	20	5	0.2	TRUE	NA
ENSG00000161217.12	.	BCM	GRCh38.p13	chr3	196257880	196257880	+	C	C	T	Missense_Mutation	SNP	ENST00000431016.6	exon3	c.G125A	p.R42Q	exonic	ENSG00000161217.12	.	nonsynonymous SNV	ENSG00000161217.12:ENST00000431016.6:exon3:c.G125A:p.R42Q	3q29	C3L-00017	6.72e-05	0	0.0005	0	0	1.526e-05	0.0011	0	rs771223117	3.19	T	T	P	B	N	D	L	.	N	0.287	T	T	T	0.226	0.281	0.694	0.033	T	T	T	T	T	D	2.107	20.200	0.994	D	N	0.070	2.771	0.166	3.020	0.918	0.732	0.744	0.710	0.714	.	5.950	4.150	1.254	0.125	0.599	1.000	0.999	0.998	754	.	.	.	.	PCYT1A	105	0	153	30	0.163934426229508	TRUE	NA
ENSG00000169676.6	.	BCM	GRCh38.p13	chr4	9783116	9783116	+	G	G	A	Missense_Mutation	SNP	ENST00000304374.4	exon1	c.G1087A	p.A363T	exonic	ENSG00000169676.6	.	nonsynonymous SNV	ENSG00000169676.6:ENST00000304374.4:exon1:c.G1087A:p.A363T	4p16.1	C3L-00017	.	.	.	.	.	.	.	.	.	11.20	D	T	D	D	D	D	M	T	D	0.240	T	T	T	0.214	0.458	0.384	0.808	T	T	T	T	D	D	3.237	24.000	0.998	D	D	0.406	4.381	0.341	3.966	0.929	0.497	0.590	0.563	0.613	.	4.590	3.750	5.396	0.188	-0.162	1.000	0.106	0.854	917	.	.	.	ID=COSV58577739;OCCURENCE=1(large_intestine)	DRD5	237	0	307	57	0.156593406593407	TRUE	TRUE
ENSG00000168594.15	.	BCM	GRCh38.p13	chr4	174976364	174976364	+	G	G	A	Missense_Mutation	SNP	ENST00000359240.7	exon5	c.G839A	p.R280Q	exonic	ENSG00000168594.15	.	nonsynonymous SNV	ENSG00000168594.15:ENST00000359240.7:exon5:c.G839A:p.R280Q	4q34.1	C3L-00017	3.407e-05	0	0	0	0	4.574e-05	0.0011	0	rs765339011	6.20	T	T	D	D	N	N	M	T	D	0.451	T	T	D	0.177	0.677	0.754	0.371	T	T	T	T	D	T	2.188	20.800	0.994	N	N	-0.357	1.478	-0.599	1.048	0.000	0.487	0.574	0.574	0.564	.	4.130	2.260	1.287	0.128	-0.259	0.019	0.000	0.000	960	Peptidase_M12B,_ADAM/reprolysin;Reprolysin_domain,_adamalysin-type	.	.	ID=COSV63660350;OCCURENCE=1(breast),2(stomach),1(pancreas)	ADAM29	66	1	74	18	0.195652173913043	TRUE	TRUE
ENSG00000112902.12	.	BCM	GRCh38.p13	chr5	9154497	9154497	+	C	C	A	Missense_Mutation	SNP	ENST00000382496.10	exon12	c.G1472T	p.R491L	exonic	ENSG00000112902.12	.	nonsynonymous SNV	ENSG00000112902.12:ENST00000382496.10:exon12:c.G1472T:p.R491L	5p15.31	C3L-00017	.	.	.	.	.	.	.	.	rs754065909	1.20	T	T	B	B	N	N	L	T	D	0.164	T	T	T	0.053	0.715	0.358	0.403	T	T	T	T	T	T	1.192	13.570	0.955	N	N	-1.080	0.325	-1.083	0.394	0.997	0.554	0.574	0.602	0.564	.	5.470	-2.130	0.320	-0.777	-1.135	0.954	0.017	0.022	950	PSI_domain	.	.	ID=COSV66785353;OCCURENCE=1(lung)	SEMA5A	220	1	301	56	0.156862745098039	TRUE	TRUE
ENSG00000204628.12	.	BCM	GRCh38.p13	chr5	181242313	181242313	+	C	C	T	Missense_Mutation	SNP	ENST00000512805.6	exon2	c.G142A	p.D48N	exonic	ENSG00000204628.12	.	nonsynonymous SNV	ENSG00000204628.12:ENST00000512805.6:exon2:c.G142A:p.D48N	5q35.3	C3L-00017	.	.	.	.	.	.	.	.	.	10.19	D	T	B	B	D	D	.	T	D	0.777	T	T	D	0.125	0.367	0.508	1.418	D	T	T	T	D	D	2.997	23.400	0.998	D	D	0.131	3.009	0.305	3.747	1.000	0.628	0.672	0.672	0.658	.	5.770	5.770	7.413	0.934	0.599	1.000	0.989	0.728	.	WD40-repeat-containing_domain	.	.	.	RACK1	89	0	151	20	0.116959064327485	TRUE	TRUE
ENSG00000146197.9	.	BCM	GRCh38.p13	chr6	35242768	35242768	+	G	G	A	Missense_Mutation	SNP	ENST00000274938.8	exon14	c.G1681A	p.E561K	exonic	ENSG00000146197.9	.	nonsynonymous SNV	ENSG00000146197.9:ENST00000274938.8:exon14:c.G1681A:p.E561K	6p21.31	C3L-00017	8.299e-06	0	0	0	0	1.508e-05	0	0	rs771897021	5.20	T	T	P	B	D	D	L	D	N	0.279	T	T	T	0.348	0.218	0.353	0.389	T	T	T	T	T	T	2.369	21.900	0.986	D	D	0.003	2.522	0.117	2.807	1.000	0.554	0.547	0.602	0.568	.	5.450	5.450	0.540	1.176	0.676	0.905	0.923	0.972	248	.	.	.	ID=COSV51455032;OCCURENCE=1(stomach),1(kidney)	SCUBE3	96	0	134	22	0.141025641025641	TRUE	TRUE
ENSG00000122687.19	.	BCM	GRCh38.p13	chr7	2235190	2235190	+	T	T	C	Missense_Mutation	SNP	ENST00000242257.14	exon3	c.A673G	p.K225E	exonic	ENSG00000122687.19	.	nonsynonymous SNV	ENSG00000122687.19:ENST00000242257.14:exon3:c.A673G:p.K225E	7p22.3	C3L-00017	.	.	.	.	.	.	.	.	.	6.19	T	T	P	P	D	D	.	T	N	0.601	T	T	T	0.137	0.460	0.639	0.715	T	T	T	T	D	D	3.798	25.800	0.997	D	D	0.562	5.560	0.537	5.511	1.000	0.722	0.702	0.698	0.735	.	5.230	5.230	7.532	1.138	0.665	1.000	0.877	0.496	857	Ribosomal_RNA_methyltransferase_FtsJ_domain	.	.	.	MRM2	236	0	380	150	0.283018867924528	TRUE	TRUE
ENSG00000122574.10	.	BCM	GRCh38.p13	chr7	29889357	29889357	+	C	C	T	Missense_Mutation	SNP	ENST00000242140.9	exon7	c.C1301T	p.P434L	exonic	ENSG00000122574.10	.	nonsynonymous SNV	ENSG00000122574.10:ENST00000242140.9:exon7:c.C1301T:p.P434L	7p14.3	C3L-00017	1.665e-05	0	0	0	0	3.006e-05	0	0	rs755603892	18.20	D	D	D	D	N	D	M	D	D	0.734	D	D	D	0.703	0.410	0.904	0.080	T	D	D	D	D	D	3.918	26.500	0.999	D	D	0.832	9.443	0.794	9.937	1.000	0.719	0.610	0.723	0.530	.	5.430	5.430	5.836	1.026	0.589	1.000	0.997	0.997	829	.	.	.	ID=COSV54208225;OCCURENCE=1(liver)	WIPF3	161	0	275	27	0.0894039735099338	TRUE	TRUE
ENSG00000128602.11	.	BCM	GRCh38.p13	chr7	129212109	129212109	+	G	G	T	Missense_Mutation	SNP	ENST00000249373.8	exon12	c.G2022T	p.K674N	exonic	ENSG00000128602.11	.	nonsynonymous SNV	ENSG00000128602.11:ENST00000249373.8:exon12:c.G2022T:p.K674N	7q32.1	C3L-00017	.	.	.	.	.	.	.	.	.	6.20	T	T	P	B	D	D	L	T	N	0.329	T	T	D	0.260	0.190	0.567	0.266	T	D	T	T	D	T	2.784	23.000	0.997	D	N	0.122	2.974	0.201	3.188	0.995	0.719	0.710	0.723	0.636	.	5.380	4.400	2.778	1.176	0.676	1.000	0.999	0.998	703	.	.	.	.	SMO	269	0	294	97	0.248081841432225	TRUE	TRUE
ENSG00000213265.8	.	BCM	GRCh38.p13	chr7	130671760	130671760	+	C	C	T	Missense_Mutation	SNP	ENST00000456951.5	exon8	c.G559A	p.E187K	exonic	ENSG00000213265.8	.	nonsynonymous SNV	ENSG00000213265.8:ENST00000456951.5:exon8:c.G559A:p.E187K	7q32.2	C3L-00017	2.471e-05	0	0	0.0001	0	1.499e-05	0	6.057e-05	rs782369380	12.19	D	D	D	D	D	D	M	.	D	0.622	T	T	T	0.169	0.308	0.230	0.305	T	T	D	D	D	T	3.702	25.400	0.999	D	N	0.547	5.425	0.558	5.736	1.000	0.603	0.574	0.574	0.663	.	5.460	5.460	2.075	1.026	0.599	0.994	0.998	0.968	940	.	.	.	ID=COSV58406542;OCCURENCE=1(stomach)	TSGA13	187	0	218	52	0.192592592592593	TRUE	TRUE
ENSG00000122728.6	.	BCM	GRCh38.p13	chr9	32633056	32633056	+	G	G	A	Missense_Mutation	SNP	ENST00000242310.4	exon1	c.C2524T	p.R842W	exonic	ENSG00000122728.6	.	nonsynonymous SNV	ENSG00000122728.6:ENST00000242310.4:exon1:c.C2524T:p.R842W	9p21.1	C3L-00017	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	M	T	D	0.216	T	T	T	0.251	0.436	0.611	0.609	T	T	T	T	D	D	3.393	24.400	0.999	D	N	0.311	3.835	0.118	2.809	0.282	0.638	0.670	0.602	0.655	.	1.190	1.190	3.554	0.310	0.268	1.000	0.982	0.977	835	Transcription_initiation_factor_TFIID_subunit_1,_domain_of_unknown_function	.	.	ID=COSV54267869;OCCURENCE=1(oesophagus)	TAF1L	630	1	975	134	0.12082957619477	NA	TRUE
ENSG00000148482.12	.	BCM	GRCh38.p13	chr10	17991172	17991172	+	G	G	A	Missense_Mutation	SNP	ENST00000377369.7	exon8	c.G1291A	p.E431K	exonic	ENSG00000148482.12	.	nonsynonymous SNV	ENSG00000148482.12:ENST00000377369.7:exon8:c.G1291A:p.E431K	10p12.33	C3L-00017	.	.	.	.	.	.	.	.	.	6.20	T	T	D	P	N	D	M	T	N	0.376	T	T	T	0.153	0.580	0.260	0.029	T	T	T	T	D	D	3.056	23.500	0.999	D	N	0.385	4.250	0.371	4.156	0.046	0.560	0.624	0.574	0.564	.	5.880	4.040	2.417	0.226	-0.107	1.000	0.993	0.993	.	.	.	.	ID=COSV66199180;OCCURENCE=1(lung)	SLC39A12	76	0	138	12	0.08	TRUE	TRUE
ENSG00000167360.6	.	BCM	GRCh38.p13	chr11	5422341	5422341	+	C	C	G	Missense_Mutation	SNP	ENST00000300778.4	exon1	c.C141G	p.I47M	exonic	ENSG00000167360.6	.	nonsynonymous SNV	ENSG00000167360.6:ENST00000300778.4:exon1:c.C141G:p.I47M	11p15.4	C3L-00017	.	.	.	.	.	.	.	.	.	9.20	D	D	D	D	N	D	M	T	D	0.379	T	T	T	0.168	0.675	0.188	0.033	T	T	T	T	D	D	1.087	12.640	0.995	N	N	-0.103	2.164	-0.316	1.532	0.191	0.487	0.563	0.574	0.564	.	5.000	-0.995	-2.748	-0.709	0.346	0.000	0.011	0.469	668	GPCR,_rhodopsin-like,_7TM	.	.	.	OR51Q1	209	0	350	47	0.118387909319899	TRUE	TRUE
ENSG00000007372.23	.	BCM	GRCh38.p13	chr11	31790743	31790743	+	G	G	A	Nonsense_Mutation	SNP	ENST00000643871.1	exon12	c.C1150T	p.Q384X	exonic	ENSG00000007372.23	.	stopgain	ENSG00000007372.23:ENST00000643871.1:exon12:c.C1150T:p.Q384X	11p13	C3L-00017	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.953	.	.	.	.	.	.	.	.	.	D	D	.	.	7.849	39	0.997	D	N	1.218	25.453	1.100	27.028	1.000	0.554	0.588	0.602	0.542	.	5.810	5.810	9.511	1.089	0.676	1.000	1.000	1.000	440	.	.	.	ID=COSV53792782;OCCURENCE=1(oesophagus)	PAX6	369	1	597	83	0.122058823529412	TRUE	TRUE
ENSG00000135362.14	.	BCM	GRCh38.p13	chr11	36462501	36462501	+	C	C	T	Missense_Mutation	SNP	ENST00000530639.6	exon9	c.C872T	p.T291M	exonic	ENSG00000135362.14	.	nonsynonymous SNV	ENSG00000135362.14:ENST00000530639.6:exon9:c.C872T:p.T291M	11p12	C3L-00017	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	M	D	D	0.945	D	D	D	0.717	0.386	0.740	0.977	T	T	D	D	D	D	3.821	25.900	0.999	D	.	0.786	8.512	0.762	9.102	1.000	0.706	0.588	0.710	0.621	.	5.240	5.240	7.223	1.026	0.599	1.000	0.998	0.997	883	.	.	.	.	PRR5L	48	0	128	25	0.163398692810458	TRUE	NA
ENSG00000110195.13	.	BCM	GRCh38.p13	chr11	72196130	72196130	+	C	C	A	Missense_Mutation	SNP	ENST00000393676.5	exon4	c.C727A	p.P243T	exonic	ENSG00000110195.13	.	nonsynonymous SNV	ENSG00000110195.13:ENST00000393676.5:exon4:c.C727A:p.P243T	11q13.4	C3L-00017	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	M	T	N	0.282	T	T	D	0.180	0.500	0.409	0.453	T	T	T	T	T	T	-0.084	0.896	0.579	N	N	-1.119	0.290	-1.239	0.252	0.054	0.554	0.574	0.602	0.530	.	4.550	-2.700	-0.824	0.128	-0.273	0.000	0.004	0.006	804	.	.	.	.	FOLR1	310	0	533	106	0.165884194053208	NA	TRUE
ENSG00000150764.14	.	BCM	GRCh38.p13	chr11	111937533	111937533	+	G	G	A	Missense_Mutation	SNP	ENST00000440460.7	exon1	c.G34A	p.D12N	exonic	ENSG00000150764.14	.	nonsynonymous SNV	ENSG00000150764.14:ENST00000440460.7:exon1:c.G34A:p.D12N	11q23.1	C3L-00017	.	.	.	.	.	.	.	.	.	7.19	D	T	B	B	D	D	L	T	N	0.343	T	T	D	0.210	0.278	0.721	0.193	.	T	T	T	D	T	3.532	24.800	0.998	D	D	0.005	2.531	0.199	3.181	1.000	0.442	0.542	0.520	0.562	.	4.860	4.860	5.939	1.101	0.590	1.000	1.000	0.999	93	.	.	.	.	DIXDC1	155	0	289	41	0.124242424242424	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-00017	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	295	1	344	74	0.177033492822967	TRUE	TRUE
ENSG00000180818.5	.	BCM	GRCh38.p13	chr12	53985277	53985277	+	T	T	G	Missense_Mutation	SNP	ENST00000303460.5	exon1	c.T18G	p.N6K	exonic	ENSG00000180818.5	.	nonsynonymous SNV	ENSG00000180818.5:ENST00000303460.5:exon1:c.T18G:p.N6K	12q13.13	C3L-00017	.	.	.	.	.	.	.	.	.	14.20	D	D	P	D	N	D	L	D	D	0.495	D	D	D	0.598	0.405	0.821	0.464	D	D	T	T	D	T	3.939	26.600	0.997	D	D	0.522	5.213	0.465	4.853	1.000	0.652	0.596	0.607	0.710	.	4.180	4.180	2.711	1.135	0.665	1.000	1.000	1.000	195	.	.	.	.	HOXC10	49	0	66	5	0.0704225352112676	TRUE	TRUE
ENSG00000123329.20	.	BCM	GRCh38.p13	chr12	57476893	57476893	+	G	G	A	Missense_Mutation	SNP	ENST00000393797.7	exon9	c.C941T	p.P314L	exonic	ENSG00000123329.20	.	nonsynonymous SNV	ENSG00000123329.20:ENST00000393797.7:exon9:c.C941T:p.P314L	12q13.3	C3L-00017	2.476e-05	9.664e-05	0	0	0	0	0	0.0001	rs145403284	9.20	D	D	D	D	N	D	M	T	D	0.576	T	T	T	0.115	.	0.792	0.317	T	T	T	T	T	D	4.166	28.300	0.992	D	N	0.239	3.482	0.228	3.323	1.000	0.677	0.522	0.673	0.530	.	4.380	4.380	3.807	1.176	0.676	0.995	0.984	0.982	323	.	.	.	ID=COSV99954603;OCCURENCE=1(central_nervous_system)	ARHGAP9	359	0	582	97	0.142857142857143	TRUE	NA
ENSG00000129566.13	.	BCM	GRCh38.p13	chr14	20396676	20396676	+	C	C	T	Missense_Mutation	SNP	ENST00000262715.10	exon10	c.G1604A	p.R535Q	exonic	ENSG00000129566.13	.	nonsynonymous SNV	ENSG00000129566.13:ENST00000262715.10:exon10:c.G1604A:p.R535Q	14q11.2	C3L-00017	8.863e-06	0	0	0	0	1.597e-05	0	0	rs769367433	8.20	T	D	D	D	D	N	M	T	N	0.354	T	T	T	0.136	0.654	0.415	0.460	T	T	T	T	D	D	2.832	23.100	0.999	D	N	0.554	5.481	0.523	5.373	1.000	0.707	0.725	0.659	0.636	.	5.590	5.590	1.794	0.955	0.530	0.919	0.964	0.852	917	TROVE_domain	.	.	ID=COSV52987297;OCCURENCE=1(oesophagus),1(large_intestine),1(NS)	TEP1	108	0	138	19	0.121019108280255	TRUE	TRUE
ENSG00000139915.21	.	BCM	GRCh38.p13	chr14	46874198	46874198	+	C	C	G	Missense_Mutation	SNP	ENST00000399232.8	exon13	c.G2440C	p.E814Q	exonic	ENSG00000139915.21	.	nonsynonymous SNV	ENSG00000139915.21:ENST00000399232.8:exon13:c.G2440C:p.E814Q	14q21.3	C3L-00017	.	.	.	.	.	.	.	.	.	7.20	D	T	B	B	U	D	M	T	N	0.469	T	T	T	0.136	0.413	0.346	1.386	T	T	T	T	D	D	2.956	23.300	0.996	D	D	0.185	3.239	0.275	3.572	0.440	0.487	0.574	0.574	0.564	.	5.680	5.680	4.730	1.008	0.599	1.000	0.999	0.986	853	MAM_domain	.	.	.	MDGA2	66	0	56	8	0.125	TRUE	TRUE
ENSG00000126777.18	.	BCM	GRCh38.p13	chr14	55678362	55678362	+	C	C	A	Nonsense_Mutation	SNP	ENST00000395314.8	exon42	c.C3866A	p.S1289X	exonic	ENSG00000126777.18	.	stopgain	ENSG00000126777.18:ENST00000395314.8:exon42:c.C3866A:p.S1289X	14q22.3	C3L-00017	.	.	.	.	.	.	.	.	.	5.7	.	.	.	.	N	A	.	.	.	0.945	.	.	.	.	.	.	.	.	.	D	D	D	.	8.372	42	0.996	D	N	0.745	7.801	0.607	6.314	0.998	0.732	0.744	0.725	0.714	.	5.600	4.710	4.264	1.026	0.599	0.998	0.873	0.984	399	.	.	.	.	KTN1	113	0	195	22	0.101382488479263	TRUE	TRUE
ENSG00000198838.13	.	BCM	GRCh38.p13	chr15	33826705	33826705	+	G	G	A	Missense_Mutation	SNP	ENST00000634891.1	exon84	c.G11198A	p.R3733H	exonic	ENSG00000198838.13	.	nonsynonymous SNV	ENSG00000198838.13:ENST00000634891.1:exon84:c.G11198A:p.R3733H	15q14	C3L-00017	3.32e-05	0.0001	8.639e-05	0	0	1.5e-05	0	6.136e-05	rs374140172	7.19	T	.	P	B	N	N	N	D	N	0.420	D	D	D	0.410	.	0.879	0.427	T	D	T	T	T	D	2.703	22.800	0.993	D	N	-0.026	2.419	0.116	2.800	0.993	0.497	0.590	0.547	0.542	.	5.150	4.230	4.220	0.245	0.676	0.656	0.735	0.938	827	RyR/IP3R_Homology_associated_domain	.	.	ID=COSV66801181;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(upper_aerodigestive_tract)	RYR3	141	0	187	57	0.233606557377049	TRUE	TRUE
ENSG00000103657.14	.	BCM	GRCh38.p13	chr15	63749502	63749502	+	C	C	A	Missense_Mutation	SNP	ENST00000443617.7	exon10	c.G2084T	p.G695V	exonic	ENSG00000103657.14	.	nonsynonymous SNV	ENSG00000103657.14:ENST00000443617.7:exon10:c.G2084T:p.G695V	15q22.31	C3L-00017	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	U	D	H	D	D	0.943	D	D	D	0.973	0.805	0.884	1.932	D	D	D	D	D	D	3.420	24.500	0.998	D	D	1.108	17.881	1.012	19.586	1.000	0.707	0.725	0.651	0.714	.	5.790	5.790	7.905	1.026	0.599	1.000	0.968	0.928	668	.	.	.	.	HERC1	186	0	197	66	0.250950570342205	TRUE	TRUE
ENSG00000138615.6	.	BCM	GRCh38.p13	chr15	65205454	65205454	+	C	C	T	Missense_Mutation	SNP	ENST00000261883.6	exon5	c.G437A	p.R146Q	exonic	ENSG00000138615.6	.	nonsynonymous SNV	ENSG00000138615.6:ENST00000261883.6:exon5:c.G437A:p.R146Q	15q22.31	C3L-00017	8.548e-06	0.0001	0	0	0	0	0	0	rs758135189	0.20	T	T	B	B	N	N	N	T	N	0.128	T	T	T	0.014	0.423	0.250	0.132	T	T	T	T	T	T	0.132	2.388	0.958	N	N	-1.112	0.296	-1.053	0.427	0.050	0.497	0.590	0.547	0.542	.	5.560	0.470	-0.210	-0.229	-0.800	0.228	0.237	0.214	649	.	.	.	.	CILP	97	0	125	52	0.293785310734463	TRUE	NA
ENSG00000103197.18	.	BCM	GRCh38.p13	chr16	2071908	2071908	+	C	C	T	Missense_Mutation	SNP	ENST00000219476.9	exon19	c.C2071T	p.R691C	exonic	ENSG00000103197.18	.	nonsynonymous SNV	ENSG00000103197.18:ENST00000219476.9:exon19:c.C2071T:p.R691C	16p13.3	C3L-00017	6.939e-05	0.0003	0	0	0	4.629e-05	0.0032	0	rs760489473	11.20	D	D	D	P	N	D	L	D	D	0.370	T	T	D	0.549	.	0.863	.	T	D	T	D	T	D	2.626	22.700	0.994	D	N	-0.510	1.157	-0.407	1.359	0.018	0.635	0.644	0.645	0.636	.	5.450	1.040	0.491	0.128	0.599	0.227	0.745	0.911	769	Tuberin-type_domain	.	.	ID=COSV54782931;OCCURENCE=1(endometrium)	TSC2	173	0	173	55	0.241228070175439	TRUE	TRUE
ENSG00000078328.21	.	BCM	GRCh38.p13	chr16	7518234	7518234	+	G	G	A	Missense_Mutation	SNP	ENST00000550418.6	exon5	c.G115A	p.A39T	exonic	ENSG00000078328.21	.	nonsynonymous SNV	ENSG00000078328.21:ENST00000550418.6:exon5:c.G115A:p.A39T	16p13.3	C3L-00017	8.241e-06	0	8.637e-05	0	0	0	0	0	rs749566543	8.20	T	T	D	D	D	D	L	T	N	0.705	T	T	T	0.205	0.119	0.320	0.018	T	T	T	T	D	D	3.543	24.800	0.996	D	D	0.268	3.619	0.390	4.286	1.000	0.554	0.574	0.618	0.564	.	4.850	4.850	9.266	1.176	0.676	1.000	0.997	0.991	964	.	.	.	ID=COSV60983781;OCCURENCE=1(liver),1(oesophagus)	RBFOX1	168	0	170	61	0.264069264069264	TRUE	TRUE
ENSG00000140678.17	.	BCM	GRCh38.p13	chr16	31359775	31359775	+	C	C	T	Missense_Mutation	SNP	ENST00000268296.9	exon6	c.C506T	p.T169M	exonic	ENSG00000140678.17	.	nonsynonymous SNV	ENSG00000140678.17:ENST00000268296.9:exon6:c.C506T:p.T169M	16p11.2	C3L-00017	5.769e-05	0.0002	0	0.0001	0	0	0	0.0002	rs146081281	2.19	T	T	B	B	.	N	L	D	N	0.127	T	T	D	0.219	.	0.343	0.214	T	T	T	T	T	T	-1.606	0.001	0.717	N	N	-2.121	0.005	-2.252	0.004	1.000	0.706	0.710	0.578	0.568	.	4.820	-9.640	-4.218	-3.928	-5.252	0.000	0.000	0.000	287	von_Willebrand_factor,_type_A	.	.	ID=COSV99191482;OCCURENCE=1(large_intestine)	ITGAX	215	0	322	38	0.105555555555556	TRUE	NA
ENSG00000172831.14	.	BCM	GRCh38.p13	chr16	66940237	66940237	+	C	C	T	Missense_Mutation	SNP	ENST00000317091.10	exon4	c.C439T	p.H147Y	exonic	ENSG00000172831.14	.	nonsynonymous SNV	ENSG00000172831.14:ENST00000317091.10:exon4:c.C439T:p.H147Y	16q22.1	C3L-00017	.	.	.	.	.	.	.	.	.	12.17	D	D	.	.	D	D	.	T	D	0.920	T	T	D	0.785	.	0.409	0.766	T	T	D	D	D	D	3.291	24.100	0.998	D	D	0.609	6.021	0.563	5.787	1.000	0.706	0.694	0.710	0.711	.	5.350	4.400	5.782	1.000	0.599	1.000	0.873	0.615	136	Carboxylesterase,_type_B	.	.	.	CES2	115	0	189	10	0.050251256281407	TRUE	NA
ENSG00000006788.14	.	BCM	GRCh38.p13	chr17	10350580	10350580	+	G	G	A	Nonsense_Mutation	SNP	ENST00000252172.9	exon12	c.C1120T	p.Q374X	exonic	ENSG00000006788.14	.	stopgain	ENSG00000006788.14:ENST00000252172.9:exon12:c.C1120T:p.Q374X	17p13.1	C3L-00017	8.259e-06	0	0	0	0	1.501e-05	0	0	rs751347030	4.5	.	.	.	.	.	A	.	.	.	0.321	.	.	.	.	.	.	.	.	.	D	D	.	.	7.956	40	0.999	D	N	1.135	19.211	0.952	16.196	1.000	0.487	0.590	0.547	0.564	.	4.150	4.150	9.846	1.172	0.672	1.000	0.985	0.815	67	Myosin_head,_motor_domain	.	.	.	MYH13	89	0	102	20	0.163934426229508	TRUE	NA
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11930047	11930047	+	C	C	T	Missense_Mutation	SNP	ENST00000262442.9	exon63	c.C12059T	p.T4020M	exonic	ENSG00000007174.18	.	nonsynonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon63:c.C12059T:p.T4020M	17p12	C3L-00017	1.653e-05	0	8.673e-05	0.0001	0	0	0	0	rs774626535	10.20	D	D	D	P	D	D	M	T	D	0.237	T	T	T	0.163	0.427	0.611	0.130	T	T	T	T	D	D	2.821	23.100	0.998	D	N	0.369	4.159	0.253	3.454	0.002	0.578	0.574	0.608	0.564	.	5.190	3.060	2.241	1.026	0.599	0.563	0.993	0.990	645	Dynein_heavy_chain_domain	.	.	.	DNAH9	185	0	188	47	0.2	TRUE	NA
ENSG00000081138.14	.	BCM	GRCh38.p13	chr18	65859020	65859020	+	G	G	A	Missense_Mutation	SNP	ENST00000397968.4	exon9	c.G1468A	p.V490I	exonic	ENSG00000081138.14	.	nonsynonymous SNV	ENSG00000081138.14:ENST00000397968.4:exon9:c.G1468A:p.V490I	18q22.1	C3L-00017	2.475e-05	0	8.696e-05	0	0	1.5e-05	0	6.058e-05	rs761625164	4.20	T	T	P	B	D	D	N	T	N	0.359	T	T	T	0.137	0.541	0.387	0.392	T	T	T	T	T	D	2.219	21.000	0.990	D	N	-0.061	2.302	-0.022	2.286	0.474	0.554	0.574	0.618	0.564	.	5.320	4.420	3.862	1.176	0.618	1.000	0.995	0.984	994	Cadherin-like	.	.	.	CDH7	178	0	276	50	0.153374233128834	TRUE	NA
ENSG00000142549.9	.	BCM	GRCh38.p13	chr19	51326878	51326878	+	G	G	A	Missense_Mutation	SNP	ENST00000270642.8	exon5	c.G626A	p.R209H	exonic	ENSG00000142549.9	.	nonsynonymous SNV	ENSG00000142549.9:ENST00000270642.8:exon5:c.G626A:p.R209H	19q13.41	C3L-00017	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	L	T	D	0.161	T	T	D	0.109	0.454	0.315	2.584	T	T	T	T	D	D	4.279	29.400	0.999	D	N	0.580	5.725	0.555	5.697	0.994	0.767	0.578	0.851	0.563	.	4.890	4.890	2.898	1.176	0.674	1.000	0.998	0.998	940	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV54536450;OCCURENCE=1(large_intestine),1(endometrium)	IGLON5	296	0	461	82	0.151012891344383	TRUE	TRUE
ENSG00000130726.12	.	BCM	GRCh38.p13	chr19	58549011	58549011	+	T	T	C	Missense_Mutation	SNP	ENST00000253024.10	exon12	c.T1433C	p.V478A	exonic	ENSG00000130726.12	.	nonsynonymous SNV	ENSG00000130726.12:ENST00000253024.10:exon12:c.T1433C:p.V478A	19q13.43	C3L-00017	.	.	.	.	.	.	.	.	.	6.20	T	D	P	B	N	D	L	T	N	0.581	T	T	D	0.151	0.356	0.569	1.104	T	T	T	T	D	T	3.100	23.600	0.981	D	D	-0.235	1.780	-0.143	1.930	1.000	0.672	0.698	0.702	0.711	.	4.950	4.950	1.308	1.129	0.654	1.000	1.000	0.891	958	.	.	.	.	TRIM28	232	0	401	80	0.166320166320166	TRUE	TRUE
ENSG00000101004.15	.	BCM	GRCh38.p13	chr20	25477030	25477030	+	C	C	T	Missense_Mutation	SNP	ENST00000278886.11	exon17	c.G2261A	p.R754H	exonic	ENSG00000101004.15	.	nonsynonymous SNV	ENSG00000101004.15:ENST00000278886.11:exon17:c.G2261A:p.R754H	20p11.21	C3L-00017	.	.	.	.	.	.	.	.	.	0.20	T	T	P	B	N	N	N	T	N	0.158	T	T	T	0.048	0.122	0.140	0.200	T	T	T	T	T	T	0.413	5.573	0.971	N	N	-1.044	0.359	-1.191	0.291	0.027	0.696	0.547	0.723	0.636	.	2.580	-1.790	-0.405	0.025	0.522	0.000	0.001	0.004	575	.	.	.	ID=COSV54000699;OCCURENCE=1(urinary_tract)	NINL	162	0	293	61	0.172316384180791	TRUE	TRUE
ENSG00000101180.16	.	BCM	GRCh38.p13	chr20	62216661	62216661	+	C	C	T	Missense_Mutation	SNP	ENST00000340177.10	exon3	c.G683A	p.R228H	exonic	ENSG00000101180.16	.	nonsynonymous SNV	ENSG00000101180.16:ENST00000340177.10:exon3:c.G683A:p.R228H	20q13.33	C3L-00017	8.511e-06	0	0	0	0	1.562e-05	0	0	rs779379623	14.20	D	D	D	D	D	D	M	T	D	0.598	T	T	D	0.339	0.790	0.820	1.392	D	T	T	T	D	D	3.465	24.600	1.000	D	D	0.460	4.738	0.433	4.605	1.000	0.701	0.547	0.717	0.563	.	4.520	4.520	3.468	1.006	0.526	0.998	0.988	0.826	856	GPCR,_rhodopsin-like,_7TM	.	.	.	HRH3	220	0	310	59	0.159891598915989	TRUE	NA
ENSG00000258555.6	.	BCM	GRCh38.p13	chr22	24321339	24321339	+	G	G	C	Missense_Mutation	SNP	ENST00000358654.2	exon5	c.G359C	p.S120T	exonic	ENSG00000258555.6	.	nonsynonymous SNV	ENSG00000258555.6:ENST00000358654.2:exon5:c.G359C:p.S120T	22q11.23	C3L-00017	.	.	.	.	.	.	.	.	.	7.16	D	D	.	.	D	D	.	T	D	0.252	T	T	T	0.066	0.142	0.575	0.378	T	.	T	T	D	T	2.151	20.500	0.990	D	N	0.051	2.698	0.237	3.368	1.000	0.707	0.725	0.725	0.714	.	5.720	4.670	3.929	1.176	0.676	0.995	1.000	0.998	862	.	.	.	.	SPECC1L-ADORA2A	402	0	414	111	0.211428571428571	TRUE	TRUE
ENSG00000196433.13	.	BCM	GRCh38.p13	chrX	1629888	1629888	+	G	G	A	Missense_Mutation	SNP	ENST00000381229.9	exon5	c.G511A	p.V171M	exonic	ENSG00000196433.13	.	nonsynonymous SNV	ENSG00000196433.13:ENST00000381229.9:exon5:c.G511A:p.V171M	Xp22.33	C3L-00017	7.413e-05	0.0002	8.637e-05	0	0.0002	7.492e-05	0	0	rs121918820	6.19	D	D	D	P	U	N	M	T	N	0.466	T	T	T	0.244	.	0.598	0.131	T	T	T	T	T	D	2.232	21.100	0.992	D	.	.	.	.	.	1.000	.	.	.	.	.	1.450	1.450	3.146	0.705	0.501	0.999	0.014	0.009	1000	O-methyltransferase,_family_2	.	.	.	ASMT	522	0	1079	80	0.0690250215703192	TRUE	NA
ENSG00000183304.10	.	BCM	GRCh38.p13	chrX	8796278	8796278	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000543214.1	exon6	c.477dupA	p.Q160Tfs*8	exonic	ENSG00000183304.10	.	frameshift insertion	ENSG00000183304.10:ENST00000543214.1:exon6:c.477dupA:p.Q160Tfs*8	Xp22.31	C3L-00017	0.0018	0.0013	0.0045	0.0009	0.0004	0.0020	0	0.0007	rs748967872	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM9A	NA	NA	NA	NA	NA	NA	NA
ENSG00000126012.12	.	BCM	GRCh38.p13	chrX	53193014	53193014	+	G	G	A	Missense_Mutation	SNP	ENST00000375401.8	exon26	c.C4636T	p.R1546W	exonic	ENSG00000126012.12	.	nonsynonymous SNV	ENSG00000126012.12:ENST00000375401.8:exon26:c.C4636T:p.R1546W	Xp11.22	C3L-00017	1.397e-05	0	0	0.0002	0	0	0	0	rs782154592	5.19	D	D	P	B	U	N	N	D	N	0.474	T	T	D	0.268	0.200	0.586	0.696	T	T	T	T	T	D	2.387	22.000	0.997	N	.	.	.	.	.	0.554	.	.	.	.	.	4.630	2.770	1.377	1.154	0.648	0.997	0.923	0.992	99	.	.	.	.	KDM5C	24	0	30	19	0.387755102040816	TRUE	NA
ENSG00000147246.10	.	BCM	GRCh38.p13	chrX	114906850	114906850	+	C	C	T	Missense_Mutation	SNP	ENST00000276198.6	exon6	c.C812T	p.T271M	exonic	ENSG00000147246.10	.	nonsynonymous SNV	ENSG00000147246.10:ENST00000276198.6:exon6:c.C812T:p.T271M	Xq23	C3L-00017	1.14e-05	0	0.0001	0	0	0	0	0	rs782383804	0.14	T	T	.	.	N	N	.	T	N	0.075	T	T	T	0.118	0.389	0.425	0.620	T	.	T	T	T	.	1.039	12.110	0.989	N	.	.	.	.	.	1.000	.	.	.	.	.	4.290	-0.148	0.457	-0.176	0.549	0.000	0.001	0.204	810	.	.	.	ID=COSV52201784;OCCURENCE=1(large_intestine),1(stomach),1(endometrium)	HTR2C	178	0	159	97	0.37890625	TRUE	TRUE
ENSG00000078900.15	.	BCM	GRCh38.p13	chr1	3730955	3730955	+	C	C	T	Silent	SNP	ENST00000378295.9	exon12	c.C1374T	p.H458H	exonic	ENSG00000078900.15	.	synonymous SNV	ENSG00000078900.15:ENST00000378295.9:exon12:c.C1374T:p.H458H	1p36.32	C3L-00017	3.42e-05	0	0.0001	0	0	0	0	0.0002	rs762610584	8.15	D	T	.	.	.	D	.	D	N	0.228	D	D	D	0.311	.	0.635	.	.	T	D	D	T	T	-0.475	0.134	0.988	N	N	-1.259	0.188	-1.315	0.199	0.790	0.672	0.702	0.645	0.613	.	5.130	-1.510	0.099	-0.721	-0.826	0.010	0.004	0.001	817	.	.	.	.	TP73	81	0	240	47	0.163763066202091	TRUE	NA
ENSG00000162728.5	.	BCM	GRCh38.p13	chr1	160084738	160084738	+	C	C	T	Silent	SNP	ENST00000368088.4	exon2	c.C708T	p.D236D	exonic	ENSG00000162728.5	.	synonymous SNV	ENSG00000162728.5:ENST00000368088.4:exon2:c.C708T:p.D236D	1q23.2	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63631533;OCCURENCE=1(large_intestine)	KCNJ9	291	1	726	85	0.104808877928483	TRUE	TRUE
ENSG00000152092.16	.	BCM	GRCh38.p13	chr1	177061117	177061117	+	C	C	T	Silent	SNP	ENST00000361833.7	exon2	c.G432A	p.S144S	exonic	ENSG00000152092.16	.	synonymous SNV	ENSG00000152092.16:ENST00000361833.7:exon2:c.G432A:p.S144S	1q25.2	C3L-00017	1.686e-05	0	0	0	0	3.036e-05	0	0	rs778838558	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56067931;OCCURENCE=1(large_intestine),1(urinary_tract)	ASTN1	65	0	74	50	0.403225806451613	TRUE	TRUE
ENSG00000115705.22	.	BCM	GRCh38.p13	chr2	1423106	1423106	+	C	C	T	Silent	SNP	ENST00000329066.9	exon3	c.C156T	p.T52T	exonic	ENSG00000115705.22	.	synonymous SNV	ENSG00000115705.22:ENST00000329066.9:exon3:c.C156T:p.T52T	2p25.3	C3L-00017	2.5e-05	0	8.712e-05	0	0	1.517e-05	0	6.101e-05	rs770575352	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TPO	436	1	710	110	0.134146341463415	TRUE	NA
ENSG00000183023.18	.	BCM	GRCh38.p13	chr2	40429288	40429288	+	C	C	T	Silent	SNP	ENST00000403092.5	exon2	c.G993A	p.K331K	exonic	ENSG00000183023.18	.	synonymous SNV	ENSG00000183023.18:ENST00000403092.5:exon2:c.G993A:p.K331K	2p22.1	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC8A1	323	0	437	55	0.111788617886179	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178725955	178725955	+	C	C	T	Silent	SNP	ENST00000591111.5	exon68	c.G19416A	p.P6472P	exonic	ENSG00000155657.27	.	synonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon68:c.G19416A:p.P6472P	2q31.2	C3L-00017	5.022e-05	0	0	0	0	9.074e-05	0	0	rs368422028	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59868786;OCCURENCE=1(cervix),1(large_intestine)	TTN	89	0	107	19	0.150793650793651	TRUE	TRUE
ENSG00000163516.14	.	BCM	GRCh38.p13	chr2	219235278	219235278	+	C	C	T	Silent	SNP	ENST00000323348.10	exon10	c.C1657T	p.L553L	exonic	ENSG00000163516.14	.	synonymous SNV	ENSG00000163516.14:ENST00000323348.10:exon10:c.C1657T:p.L553L	2q35	C3L-00017	.	.	.	.	.	.	.	.	rs113918917	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANKZF1	100	0	191	42	0.180257510729614	TRUE	NA
ENSG00000164078.13	.	BCM	GRCh38.p13	chr3	49895267	49895267	+	G	G	T	Silent	SNP	ENST00000296474.8	exon14	c.C3171A	p.I1057I	exonic	ENSG00000164078.13	.	synonymous SNV	ENSG00000164078.13:ENST00000296474.8:exon14:c.C3171A:p.I1057I	3p21.31	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MST1R	491	0	863	53	0.0578602620087336	TRUE	TRUE
ENSG00000206384.10	.	BCM	GRCh38.p13	chr3	130563474	130563474	+	C	C	T	Silent	SNP	ENST00000358511.10	exon2	c.C471T	p.D157D	exonic	ENSG00000206384.10	.	synonymous SNV	ENSG00000206384.10:ENST00000358511.10:exon2:c.C471T:p.D157D	3q22.1	C3L-00017	6.629e-05	0	0.0002	0	0	5.997e-05	0	0.0001	rs748065583	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62019101;OCCURENCE=1(large_intestine),1(bone),1(thyroid)	COL6A6	220	0	318	52	0.140540540540541	TRUE	TRUE
ENSG00000028310.18	.	BCM	GRCh38.p13	chr5	865469	865469	+	C	C	T	Silent	SNP	ENST00000467963.6	exon15	c.G1638A	p.P546P	exonic	ENSG00000028310.18	.	synonymous SNV	ENSG00000028310.18:ENST00000467963.6:exon15:c.G1638A:p.P546P	5p15.33	C3L-00017	0.0017	0.0187	0.0008	0	0	4.531e-05	0	0	rs112085533	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BRD9	125	0	188	35	0.15695067264574	TRUE	NA
ENSG00000113430.10	.	BCM	GRCh38.p13	chr5	1879787	1879787	+	G	G	A	Silent	SNP	ENST00000231357.7	exon4	c.C453T	p.R151R	exonic	ENSG00000113430.10	.	synonymous SNV	ENSG00000113430.10:ENST00000231357.7:exon4:c.C453T:p.R151R	5p15.33	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51472689;OCCURENCE=1(large_intestine)	IRX4	221	0	261	52	0.166134185303514	TRUE	TRUE
ENSG00000186479.5	.	BCM	GRCh38.p13	chr5	64575777	64575777	+	G	G	A	Silent	SNP	ENST00000334025.3	exon3	c.G336A	p.P112P	exonic	ENSG00000186479.5	.	synonymous SNV	ENSG00000186479.5:ENST00000334025.3:exon3:c.G336A:p.P112P	5q12.3	C3L-00017	2.497e-05	9.623e-05	0	0	0	0	0	0.0001	rs142936124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RGS7BP	114	0	126	18	0.125	TRUE	NA
ENSG00000152377.14	.	BCM	GRCh38.p13	chr5	137498547	137498547	+	G	G	A	Silent	SNP	ENST00000394945.6	exon2	c.C12T	p.I4I	exonic	ENSG00000152377.14	.	synonymous SNV	ENSG00000152377.14:ENST00000394945.6:exon2:c.C12T:p.I4I	5q31.2	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPOCK1	78	0	132	18	0.12	TRUE	NA
ENSG00000164853.9	.	BCM	GRCh38.p13	chr7	1236539	1236539	+	G	G	T	Silent	SNP	ENST00000316333.9	exon3	c.G1158T	p.P386P	exonic	ENSG00000164853.9	.	synonymous SNV	ENSG00000164853.9:ENST00000316333.9:exon3:c.G1158T:p.P386P	7p22.3	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UNCX	88	0	223	36	0.138996138996139	TRUE	TRUE
ENSG00000096968.14	.	BCM	GRCh38.p13	chr9	5055779	5055779	+	T	T	G	Silent	SNP	ENST00000381652.4	exon8	c.T1047G	p.G349G	exonic	ENSG00000096968.14	.	synonymous SNV	ENSG00000096968.14:ENST00000381652.4:exon8:c.T1047G:p.G349G	9p24.1	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	JAK2	146	0	134	21	0.135483870967742	TRUE	TRUE
ENSG00000107731.12	.	BCM	GRCh38.p13	chr10	71279861	71279861	+	G	G	A	Silent	SNP	ENST00000335350.10	exon2	c.G120A	p.P40P	exonic	ENSG00000107731.12	.	synonymous SNV	ENSG00000107731.12:ENST00000335350.10:exon2:c.G120A:p.P40P	10q22.1	C3L-00017	7.538e-05	0.0006	0	0.0001	0	3.06e-05	0	0	rs144307815	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UNC5B	289	0	373	89	0.192640692640693	TRUE	NA
ENSG00000148814.18	.	BCM	GRCh38.p13	chr10	132348057	132348057	+	G	G	A	Silent	SNP	ENST00000368614.8	exon6	c.G627A	p.A209A	exonic	ENSG00000148814.18	.	synonymous SNV	ENSG00000148814.18:ENST00000368614.8:exon6:c.G627A:p.A209A	10q26.3	C3L-00017	7.434e-05	0.0003	0	0	0.0002	4.513e-05	0	0.0001	rs758352841	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59806984;OCCURENCE=1(central_nervous_system),1(lung)	LRRC27	173	0	271	34	0.111475409836066	TRUE	TRUE
ENSG00000182272.12	.	BCM	GRCh38.p13	chr11	375893	375893	+	C	C	T	Silent	SNP	ENST00000329962.11	exon11	c.C1032T	p.C344C	exonic	ENSG00000182272.12	.	synonymous SNV	ENSG00000182272.12:ENST00000329962.11:exon11:c.C1032T:p.C344C	11p15.5	C3L-00017	.	.	.	.	.	.	.	.	rs1035639538	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100327087;OCCURENCE=1(endometrium)	B4GALNT4	208	0	379	47	0.110328638497653	TRUE	NA
ENSG00000109906.14	.	BCM	GRCh38.p13	chr11	114186983	114186983	+	C	C	T	Silent	SNP	ENST00000335953.9	exon4	c.C1398T	p.C466C	exonic	ENSG00000109906.14	.	synonymous SNV	ENSG00000109906.14:ENST00000335953.9:exon4:c.C1398T:p.C466C	11q23.2	C3L-00017	4.119e-05	0.0003	0	0	0	1.499e-05	0	6.057e-05	rs116547293	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60091982;OCCURENCE=2(large_intestine)	ZBTB16	456	0	627	100	0.137551581843191	TRUE	TRUE
ENSG00000174527.9	.	BCM	GRCh38.p13	chr12	109388781	109388781	+	G	G	A	Silent	SNP	ENST00000310903.9	exon2	c.G111A	p.A37A	exonic	ENSG00000174527.9	.	synonymous SNV	ENSG00000174527.9:ENST00000310903.9:exon2:c.G111A:p.A37A	12q24.11	C3L-00017	4.152e-05	0.0004	0	0	0	1.501e-05	0	0	rs548292658	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60451628;OCCURENCE=1(large_intestine),1(biliary_tract)	MYO1H	94	0	114	16	0.123076923076923	TRUE	TRUE
ENSG00000102699.6	.	BCM	GRCh38.p13	chr13	24426501	24426501	+	T	T	C	Silent	SNP	ENST00000381989.4	exon33	c.A4944G	p.K1648K	exonic	ENSG00000102699.6	.	synonymous SNV	ENSG00000102699.6:ENST00000381989.4:exon33:c.A4944G:p.K1648K	13q12.12	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PARP4	195	0	181	53	0.226495726495726	NA	TRUE
ENSG00000254585.5	.	BCM	GRCh38.p13	chr15	23646522	23646522	+	C	C	T	Silent	SNP	ENST00000650528.1	exon1	c.G1221A	p.P407P	exonic	ENSG00000254585.5	.	synonymous SNV	ENSG00000254585.5:ENST00000650528.1:exon1:c.G1221A:p.P407P	15q11.2	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAGEL2	18	0	39	9	0.1875	TRUE	NA
ENSG00000159433.12	.	BCM	GRCh38.p13	chr15	42693695	42693695	+	G	G	A	Silent	SNP	ENST00000290607.12	exon23	c.G12117A	p.P4039P	exonic	ENSG00000159433.12	.	synonymous SNV	ENSG00000159433.12:ENST00000290607.12:exon23:c.G12117A:p.P4039P	15q15.2	C3L-00017	.	.	.	.	.	.	.	.	rs922143606	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STARD9	215	0	327	81	0.198529411764706	TRUE	NA
ENSG00000120071.14	.	BCM	GRCh38.p13	chr17	46038616	46038616	+	G	G	A	Silent	SNP	ENST00000432791.6	exon10	c.C2463T	p.P821P	exonic	ENSG00000120071.14	.	synonymous SNV	ENSG00000120071.14:ENST00000432791.6:exon10:c.C2463T:p.P821P	17q21.31	C3L-00017	2.472e-05	0	0	0	0	0	0	0.0002	rs765044321	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KANSL1	192	0	228	49	0.176895306859206	TRUE	NA
ENSG00000182621.18	.	BCM	GRCh38.p13	chr20	8757159	8757159	+	C	C	A	Silent	SNP	ENST00000338037.11	exon24	c.C2637A	p.L879L	exonic	ENSG00000182621.18	.	synonymous SNV	ENSG00000182621.18:ENST00000338037.11:exon24:c.C2637A:p.L879L	20p12.3	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLCB1	71	0	110	8	0.0677966101694915	TRUE	TRUE
ENSG00000156299.13	.	BCM	GRCh38.p13	chr21	31141326	31141326	+	G	G	A	Silent	SNP	ENST00000286827.7	exon22	c.C3654T	p.D1218D	exonic	ENSG00000156299.13	.	synonymous SNV	ENSG00000156299.13:ENST00000286827.7:exon22:c.C3654T:p.D1218D	21q22.11	C3L-00017	8.258e-06	0	0	0	0	1.502e-05	0	0	rs375189386	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54539208;OCCURENCE=1(oesophagus),1(large_intestine),1(stomach)	TIAM1	131	0	224	21	0.0857142857142857	TRUE	TRUE
ENSG00000008256.16	.	BCM	GRCh38.p13	chr7	6172885	6172885	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000008256.16	.	.	.	7p22.1	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CYTH3	51	0	96	40	0.294117647058824	TRUE	NA
ENSG00000122550.18	.	BCM	GRCh38.p13	chr7	23174452	23174452	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000122550.18	ENST00000339077.10:c.*154G>A	.	.	7p15.3	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KLHL7	404	0	514	42	0.0755395683453237	TRUE	NA
ENSG00000158516.12	.	BCM	GRCh38.p13	chr7	130282101	130282101	+	-	NA	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000158516.12	.	.	.	7q32.2	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPA2	NA	NA	NA	NA	NA	NA	NA
ENSG00000139629.16	.	BCM	GRCh38.p13	chr12	51403210	51403210	+	G	G	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000139629.16;ENSG00000271065.1	dist=11804;dist=18746	.	.	12q13.13	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GALNT6	146	0	203	36	0.150627615062762	TRUE	NA
ENSG00000165899.11	.	BCM	GRCh38.p13	chr12	80436301	80436301	+	C	C	G	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000165899.11;ENSG00000139304.16	dist=55422;dist=7934	.	.	12q21.31	C3L-00017	.	.	.	.	.	.	.	.	.	3.12	T	.	.	.	.	.	.	T	D	.	T	T	.	0.255	0.565	0.067	.	.	T	T	T	D	T	1.031	12.010	0.777	D	N	0.023	2.593	-0.024	2.278	0.026	0.487	0.574	0.574	0.564	.	4.840	4.840	3.536	0.028	0.587	1.000	0.043	0.005	900	Fibronectin_type_III	.	.	.	OTOGL	85	0	111	11	0.0901639344262295	TRUE	TRUE
ENSG00000092140.16	.	BCM	GRCh38.p13	chr14	30560761	30560761	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000092140.16	.	.	.	14q12	C3L-00017	.	.	.	.	.	.	.	.	.	1.14	D	.	.	.	.	N	.	T	N	0.283	T	T	T	0.056	0.398	0.247	.	.	T	T	T	T	T	0.834	9.733	0.628	N	N	-0.741	0.746	-0.910	0.607	1.000	0.033	0.435	0.507	0.404	.	3.340	0.811	1.433	0.171	-0.150	0.017	0.041	0.012	963	.	.	.	.	G2E3	110	0	144	34	0.191011235955056	TRUE	TRUE
ENSG00000054690.14	.	BCM	GRCh38.p13	chr14	67586416	67586416	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000054690.14	.	.	.	14q24.1	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEKHH1	281	0	356	42	0.105527638190955	TRUE	NA
ENSG00000169896.18	.	BCM	GRCh38.p13	chr16	31326962	31326962	+	G	G	-	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000169896.18	.	.	.	16p11.2	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITGAM	208	0	230	47	0.169675090252708	TRUE	NA
ENSG00000265179.7	.	BCM	GRCh38.p13	chr18	905015	905015	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000265179.7	.	.	.	18p11.32	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AP000894.2	104	0	182	25	0.120772946859903	TRUE	NA
ENSG00000243064.8	.	BCM	GRCh38.p13	chr21	14291613	14291613	+	A	A	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000243064.8	.	.	.	21q11.2	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABCC13	115	0	145	15	0.09375	TRUE	NA
ENSG00000100220.12	.	BCM	GRCh38.p13	chr22	32388044	32388045	+	CC	CC	TT	Unknown	MNP	ENST00000216038.6	exon12	c.1465_1466delinsAA	p.G489K	exonic	ENSG00000100220.12	.	nonframeshift substitution	ENSG00000100220.12:ENST00000216038.6:exon12:c.1465_1466delinsAA:p.G489K	22q12.3	C3L-00017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RTCB	179	73	240	66	0.215686274509804	TRUE	TRUE
ENSG00000066056.14	.	BCM	GRCh38.p13	chr1	43307444	43307444	+	G	G	A	Missense_Mutation	SNP	ENST00000372476.8	exon6	c.G785A	p.G262D	exonic	ENSG00000066056.14	.	nonsynonymous SNV	ENSG00000066056.14:ENST00000372476.8:exon6:c.G785A:p.G262D	1p34.2	C3L-01689	.	.	.	.	.	.	.	.	.	13.20	T	T	D	D	N	D	M	D	N	0.902	D	D	D	0.531	0.112	0.982	1.235	T	T	D	D	D	T	4.183	28.500	0.998	D	D	0.830	9.403	0.802	10.187	1.000	0.672	0.693	0.645	0.711	.	5.260	5.260	9.559	1.176	0.618	1.000	0.996	0.917	662	.	.	.	.	TIE1	204	0	354	320	0.474777448071217	TRUE	TRUE
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237550644	237550644	+	C	C	T	Missense_Mutation	SNP	ENST00000366574.7	exon27	c.C3167T	p.T1056M	exonic	ENSG00000198626.17	.	nonsynonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon27:c.C3167T:p.T1056M	1q43	C3L-01689	2.62e-05	0	0	0	0	0	0	0.0001	rs779146564	17.19	D	.	D	P	U	D	M	D	D	0.891	D	D	D	0.802	0.495	0.871	1.164	D	D	D	D	D	D	3.604	25.100	0.999	D	D	0.782	8.437	0.715	8.049	1.000	0.554	0.574	0.618	0.564	.	5.140	5.140	7.798	1.026	0.599	1.000	0.689	0.576	940	0.000	.	.	ID=COSV63707037;OCCURENCE=1(large_intestine),2(stomach)	RYR2	168	0	144	34	0.191011235955056	TRUE	TRUE
ENSG00000168754.15	.	BCM	GRCh38.p13	chr2	96972122	96972122	+	C	C	T	Missense_Mutation	SNP	ENST00000490605.3	exon3	c.G343A	p.V115M	exonic	ENSG00000168754.15	.	nonsynonymous SNV	ENSG00000168754.15:ENST00000490605.3:exon3:c.G343A:p.V115M	2q11.2	C3L-01689	0.0001	0	0	0	0	0	0	0.0003	rs533483443	3.15	D	D	.	.	.	N	.	T	N	0.183	T	T	D	0.109	.	0.270	0.367	T	.	T	T	T	T	1.129	13.040	0.994	N	N	-0.921	0.494	-1.073	0.404	0.017	0.497	0.547	0.578	0.542	.	4.040	-1.140	-0.817	0.113	-0.313	0.000	0.018	0.001	86	.	.	.	ID=COSV59970237;OCCURENCE=2(liver)	FAM178B	54	0	98	16	0.140350877192982	TRUE	TRUE
ENSG00000163075.13	.	BCM	GRCh38.p13	chr2	119627712	119627712	+	T	T	C	Missense_Mutation	SNP	ENST00000413369.8	exon16	c.T1576C	p.F526L	exonic	ENSG00000163075.13	.	nonsynonymous SNV	ENSG00000163075.13:ENST00000413369.8:exon16:c.T1576C:p.F526L	2q14.2	C3L-01689	8.237e-06	0	0	0	0	1.499e-05	0	0	rs764563519	0.20	T	T	B	B	N	N	L	T	N	0.266	T	T	T	0.061	0.244	0.061	0.022	T	T	T	T	T	T	1.057	12.320	0.536	N	N	-0.846	0.591	-0.808	0.746	0.727	0.554	0.590	0.602	0.530	.	4.180	4.180	1.892	1.123	0.645	0.036	0.017	0.013	908	.	.	.	.	CFAP221	239	0	344	64	0.156862745098039	TRUE	NA
ENSG00000187231.14	.	BCM	GRCh38.p13	chr2	179172148	179172148	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000428443.8	exon5	c.340dupT	p.W114Lfs*6	exonic	ENSG00000187231.14	.	frameshift insertion	ENSG00000187231.14:ENST00000428443.8:exon5:c.340dupT:p.W114Lfs*6	2q31.2	C3L-01689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SESTD1	NA	NA	NA	NA	NA	NA	NA
ENSG00000163053.11	.	BCM	GRCh38.p13	chr2	230046366	230046366	+	C	C	T	Missense_Mutation	SNP	ENST00000295190.9	exon4	c.G760A	p.G254R	exonic	ENSG00000163053.11	.	nonsynonymous SNV	ENSG00000163053.11:ENST00000295190.9:exon4:c.G760A:p.G254R	2q36.3	C3L-01689	8.268e-06	0	0	0	0	1.504e-05	0	0	rs754868546	0.20	T	T	B	B	N	N	L	T	N	0.076	T	T	T	0.058	0.502	0.040	0.447	T	T	T	T	T	T	0.635	7.849	0.541	N	N	-0.974	0.432	-0.994	0.497	0.001	0.615	0.588	0.616	0.621	.	4.800	0.795	0.205	1.026	0.599	0.000	0.012	0.030	952	Major_facilitator_superfamily_domain	.	.	.	SLC16A14	306	0	350	89	0.202733485193622	TRUE	NA
ENSG00000114446.5	.	BCM	GRCh38.p13	chr3	108166927	108166927	+	C	C	T	Missense_Mutation	SNP	ENST00000264538.4	exon8	c.G908A	p.R303Q	exonic	ENSG00000114446.5	.	nonsynonymous SNV	ENSG00000114446.5:ENST00000264538.4:exon8:c.G908A:p.R303Q	3q13.12	C3L-01689	1.659e-05	0	0	0	0	1.507e-05	0	6.066e-05	rs771681320	18.19	D	D	D	D	D	D	M	.	D	0.953	D	D	D	0.733	0.935	0.827	0.845	T	D	D	D	D	D	4.127	28.000	1.000	D	D	0.951	12.456	0.903	13.884	1.000	0.693	0.659	0.659	0.564	.	5.780	5.780	7.032	1.026	0.599	1.000	1.000	0.992	438	.	.	.	ID=COSV52708404;OCCURENCE=1(pancreas)	IFT57	297	0	337	54	0.138107416879795	TRUE	TRUE
ENSG00000152580.8	.	BCM	GRCh38.p13	chr3	151446488	151446488	+	C	C	T	Missense_Mutation	SNP	ENST00000282466.3	exon4	c.G3493A	p.V1165M	exonic	ENSG00000152580.8	.	nonsynonymous SNV	ENSG00000152580.8:ENST00000282466.3:exon4:c.G3493A:p.V1165M	3q25.1	C3L-01689	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.035	T	T	T	0.028	0.152	0.303	0.022	T	T	T	T	T	T	-0.023	1.197	0.463	N	N	-1.087	0.318	-1.078	0.399	1.000	0.554	0.574	0.602	0.542	.	5.120	0.628	-0.178	-0.771	-0.427	0.000	0.002	0.015	813	.	.	.	.	IGSF10	287	1	390	61	0.135254988913525	TRUE	TRUE
ENSG00000109606.13	.	BCM	GRCh38.p13	chr4	24570657	24570657	+	A	A	C	Missense_Mutation	SNP	ENST00000336812.5	exon3	c.T698G	p.L233R	exonic	ENSG00000109606.13	.	nonsynonymous SNV	ENSG00000109606.13:ENST00000336812.5:exon3:c.T698G:p.L233R	4p15.2	C3L-01689	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.980	D	T	D	0.792	0.852	0.913	3.539	D	T	D	D	D	D	4.823	33	0.997	D	D	1.035	15.057	0.929	15.031	1.000	0.737	0.699	0.733	0.711	.	5.380	5.380	8.947	1.312	0.691	1.000	1.000	0.990	548	Helicase_superfamily_1/2,_ATP-binding_domain;DEAD/DEAH_box_helicase_domain	.	.	.	DHX15	200	0	208	54	0.206106870229008	TRUE	TRUE
ENSG00000174123.11	.	BCM	GRCh38.p13	chr4	38774632	38774632	+	T	T	C	Missense_Mutation	SNP	ENST00000308973.9	exon4	c.A959G	p.Y320C	exonic	ENSG00000174123.11	.	nonsynonymous SNV	ENSG00000174123.11:ENST00000308973.9:exon4:c.A959G:p.Y320C	4p14	C3L-01689	.	.	.	.	.	.	.	.	.	16.20	D	D	D	P	D	D	M	D	D	0.704	D	D	D	0.663	0.444	0.984	0.372	T	T	D	D	D	T	3.446	24.500	0.997	D	D	0.473	4.834	0.386	4.260	1.000	0.632	0.698	0.547	0.530	.	5.130	3.900	5.930	1.138	0.609	1.000	0.809	0.700	725	.	.	.	.	TLR10	98	0	90	21	0.189189189189189	TRUE	TRUE
ENSG00000138802.11	.	BCM	GRCh38.p13	chr4	109463084	109463084	+	C	C	A	Missense_Mutation	SNP	ENST00000265175.5	exon2	c.C317A	p.T106K	exonic	ENSG00000138802.11	.	nonsynonymous SNV	ENSG00000138802.11:ENST00000265175.5:exon2:c.C317A:p.T106K	4q25	C3L-01689	.	.	.	.	.	.	.	.	.	2.20	D	T	B	B	N	N	N	T	N	0.470	T	T	D	0.138	0.306	0.294	0.217	T	T	T	T	T	T	1.291	14.320	0.914	N	N	-0.802	0.651	-0.744	0.836	1.000	0.707	0.725	0.725	0.714	.	5.260	4.410	1.779	1.026	0.549	0.004	0.024	0.268	885	.	.	.	ID=COSV99494207;OCCURENCE=1(ovary)	SEC24B	296	0	309	89	0.223618090452261	TRUE	TRUE
ENSG00000169194.9	.	BCM	GRCh38.p13	chr5	132659745	132659745	+	C	C	G	Missense_Mutation	SNP	ENST00000304506.7	exon3	c.C250G	p.L84V	exonic	ENSG00000169194.9	.	nonsynonymous SNV	ENSG00000169194.9:ENST00000304506.7:exon3:c.C250G:p.L84V	5q31.1	C3L-01689	.	.	.	.	.	.	.	.	.	5.16	D	T	.	.	N	N	.	T	D	0.644	T	T	D	0.312	0.765	0.839	0.608	T	.	D	T	D	T	2.252	21.200	0.997	N	N	0.162	3.140	-0.039	2.232	1.000	0.601	0.597	0.578	0.613	.	4.020	4.020	0.649	0.947	0.599	0.117	0.112	0.554	882	.	.	.	.	IL13	166	0	201	41	0.169421487603306	TRUE	TRUE
ENSG00000113108.19	.	BCM	GRCh38.p13	chr5	140558757	140558757	+	C	C	T	Missense_Mutation	SNP	ENST00000357560.8	exon13	c.G1289A	p.R430H	exonic	ENSG00000113108.19	.	nonsynonymous SNV	ENSG00000113108.19:ENST00000357560.8:exon13:c.G1289A:p.R430H	5q31.3	C3L-01689	8.668e-06	0	0	0	0	0	0	6.112e-05	rs755227669	8.20	D	T	D	D	N	D	L	T	N	0.160	T	T	D	0.106	0.337	0.620	1.018	T	T	T	T	D	D	2.997	23.400	0.999	D	N	0.404	4.368	0.405	4.397	1.000	0.651	0.644	0.644	0.684	.	4.760	4.760	1.052	1.026	0.599	0.730	1.000	0.996	214	.	.	.	ID=COSV60366572;OCCURENCE=1(stomach)	APBB3	197	0	255	57	0.182692307692308	TRUE	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152442086	152442086	+	G	G	A	Missense_Mutation	SNP	ENST00000367255.10	exon31	c.C3997T	p.R1333C	exonic	ENSG00000131018.24	.	nonsynonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon31:c.C3997T:p.R1333C	6q25.2	C3L-01689	.	.	.	.	.	.	.	.	rs1018039106	16.20	D	D	D	P	N	D	M	D	D	0.495	D	D	D	0.225	0.397	0.915	0.556	T	D	D	T	D	D	3.299	24.100	0.999	D	D	0.551	5.457	0.559	5.743	0.055	0.487	0.574	0.489	0.564	.	5.190	5.190	3.624	1.176	0.676	1.000	0.963	0.733	699	.	.	.	ID=COSV54900080;OCCURENCE=1(large_intestine),2(stomach),2(haematopoietic_and_lymphoid_tissue)	SYNE1	458	0	621	136	0.179656538969617	TRUE	TRUE
ENSG00000221900.6	.	BCM	GRCh38.p13	chr7	53035817	53035817	+	G	G	A	Missense_Mutation	SNP	ENST00000408890.6	exon1	c.G146A	p.R49H	exonic	ENSG00000221900.6	.	nonsynonymous SNV	ENSG00000221900.6:ENST00000408890.6:exon1:c.G146A:p.R49H	7p12.1	C3L-01689	0.0001	0	0	0.0015	0	0	0	0.0002	rs558199586	0.19	T	T	B	B	.	N	N	T	N	0.026	T	T	T	0.012	0.107	0.014	0.074	T	T	T	T	T	T	-0.232	0.436	0.912	N	N	-1.993	0.009	-2.094	0.008	0.004	0.487	0.574	0.547	0.564	.	1.680	-3.360	-2.133	-0.366	-0.330	0.000	0.000	0.001	981	.	.	.	ID=COSV68693778;OCCURENCE=2(large_intestine)	POM121L12	331	2	424	89	0.173489278752437	TRUE	TRUE
ENSG00000165102.15	.	BCM	GRCh38.p13	chr8	43199525	43199525	+	A	A	G	Missense_Mutation	SNP	ENST00000379644.9	exon18	c.A1864G	p.I622V	exonic	ENSG00000165102.15	.	nonsynonymous SNV	ENSG00000165102.15:ENST00000379644.9:exon18:c.A1864G:p.I622V	8p11.21	C3L-01689	.	.	.	.	.	.	.	.	.	9.16	D	T	.	.	D	D	.	T	N	0.384	T	T	D	0.445	.	0.758	0.229	T	.	D	T	D	D	3.056	23.500	0.997	D	D	0.529	5.270	0.546	5.611	1.000	0.707	0.725	0.653	0.714	.	5.290	5.290	7.025	1.312	0.756	1.000	0.997	0.994	478	.	.	.	.	HGSNAT	93	0	117	20	0.145985401459854	TRUE	TRUE
ENSG00000167123.19	.	BCM	GRCh38.p13	chr9	128424441	128424441	+	C	C	A	Missense_Mutation	SNP	ENST00000372838.9	exon5	c.C593A	p.P198H	exonic	ENSG00000167123.19	.	nonsynonymous SNV	ENSG00000167123.19:ENST00000372838.9:exon5:c.C593A:p.P198H	9q34.11	C3L-01689	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	D	D	M	T	D	0.686	T	T	D	0.226	0.334	0.726	0.629	T	T	T	T	D	D	3.754	25.600	0.997	D	D	0.612	6.047	0.543	5.572	1.000	0.707	0.670	0.668	0.714	.	4.750	3.860	2.877	1.026	0.549	1.000	0.992	0.929	389	.	.	.	.	CERCAM	415	1	614	137	0.182423435419441	TRUE	TRUE
ENSG00000165312.6	.	BCM	GRCh38.p13	chr10	23439710	23439710	+	G	G	T	Missense_Mutation	SNP	ENST00000376495.4	exon1	c.G253T	p.A85S	exonic	ENSG00000165312.6	.	nonsynonymous SNV	ENSG00000165312.6:ENST00000376495.4:exon1:c.G253T:p.A85S	10p12.2	C3L-01689	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	U	N	L	.	N	0.097	T	T	D	0.038	0.226	0.124	.	T	T	T	T	T	T	1.795	17.690	0.927	N	N	-0.755	0.723	-0.677	0.933	1.000	0.658	0.172	0.619	0.622	.	2.200	1.170	0.934	0.909	0.453	0.979	0.852	0.802	921	.	.	.	.	OTUD1	97	0	176	67	0.275720164609054	TRUE	TRUE
ENSG00000172987.13	.	BCM	GRCh38.p13	chr10	98743982	98743982	+	G	G	A	Missense_Mutation	SNP	ENST00000370552.8	exon4	c.C685T	p.R229C	exonic	ENSG00000172987.13	.	nonsynonymous SNV	ENSG00000172987.13:ENST00000370552.8:exon4:c.C685T:p.R229C	10q24.2	C3L-01689	6.592e-05	0	8.64e-05	0.0001	0	8.991e-05	0	0	rs539208193	8.20	D	D	D	P	N	D	N	T	N	0.336	T	T	D	0.194	.	0.356	0.704	T	T	T	T	T	D	4.249	29.100	0.999	D	D	0.448	4.656	0.498	5.141	0.836	0.487	0.574	0.574	0.564	.	5.680	4.780	5.438	1.176	0.618	1.000	1.000	0.999	289	.	.	.	ID=COSV65183049;OCCURENCE=1(breast)	HPSE2	536	0	679	133	0.163793103448276	TRUE	TRUE
ENSG00000184956.16	.	BCM	GRCh38.p13	chr11	1026442	1026442	+	C	C	G	Missense_Mutation	SNP	ENST00000421673.7	exon20	c.G2431C	p.E811Q	exonic	ENSG00000184956.16	.	nonsynonymous SNV	ENSG00000184956.16:ENST00000421673.7:exon20:c.G2431C:p.E811Q	11p15.5	C3L-01689	.	.	.	.	.	.	.	.	.	0.18	T	T	P	B	.	N	L	T	N	0.136	T	T	T	0.033	0.505	0.197	0.088	T	T	T	T	T	.	0.604	7.553	0.671	N	N	-1.158	0.258	-1.357	0.175	0.215	0.421	0.551	0.578	0.563	.	3.480	-3.170	0.082	-1.281	-0.910	0.000	0.006	0.082	825	Trypsin_Inhibitor-like,_cysteine_rich_domain	.	.	.	MUC6	45	0	116	14	0.107692307692308	TRUE	TRUE
ENSG00000166105.16	.	BCM	GRCh38.p13	chr11	134283757	134283757	+	G	G	A	Missense_Mutation	SNP	ENST00000431683.7	exon6	c.G548A	p.R183Q	exonic	ENSG00000166105.16	.	nonsynonymous SNV	ENSG00000166105.16:ENST00000431683.7:exon6:c.G548A:p.R183Q	11q25	C3L-01689	4.722e-05	0	0	0.0005	0	1.676e-05	0	0	rs550517910	2.19	T	T	B	B	.	N	N	D	N	0.195	T	D	T	0.178	0.370	0.219	0.040	T	T	T	T	T	T	-0.807	0.024	0.795	N	N	-1.426	0.106	-1.428	0.138	0.784	0.707	0.588	0.725	0.542	.	4.490	-2.440	-0.109	-2.657	-2.822	0.000	0.000	0.002	930	Glycoside_hydrolase_35,_catalytic_domain	.	.	ID=COSV66281241;OCCURENCE=1(cervix),1(large_intestine),1(NS),1(soft_tissue)	GLB1L3	193	1	257	60	0.189274447949527	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01689	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	450	0	543	124	0.185907046476762	TRUE	TRUE
ENSG00000187950.8	.	BCM	GRCh38.p13	chr12	29427638	29427638	+	G	G	A	Missense_Mutation	SNP	ENST00000318184.9	exon28	c.C3338T	p.A1113V	exonic	ENSG00000187950.8	.	nonsynonymous SNV	ENSG00000187950.8:ENST00000318184.9:exon28:c.C3338T:p.A1113V	12p11.22	C3L-01689	.	.	.	.	.	.	.	.	.	3.14	D	D	.	.	.	N	.	D	N	0.094	T	T	T	0.270	0.104	0.644	0.038	T	.	T	T	T	.	0.362	4.996	0.587	N	N	-0.774	0.693	-1.010	0.477	0.793	0.487	0.547	0.574	0.613	.	0.724	-0.631	-0.775	0.573	0.567	0.000	0.087	0.066	818	.	.	.	.	OVCH1	193	0	386	25	0.0608272506082725	TRUE	TRUE
ENSG00000166886.13	.	BCM	GRCh38.p13	chr12	57091655	57091655	+	C	C	T	Missense_Mutation	SNP	ENST00000300131.8	exon2	c.C614T	p.S205L	exonic	ENSG00000166886.13	.	nonsynonymous SNV	ENSG00000166886.13:ENST00000300131.8:exon2:c.C614T:p.S205L	12q13.3	C3L-01689	.	.	.	.	.	.	.	.	.	3.19	T	T	D	P	N	N	L	.	N	0.326	T	T	T	0.070	0.411	0.289	1.474	T	T	T	T	D	D	2.666	22.800	0.999	N	N	0.067	2.758	0.057	2.563	1.000	0.490	0.714	0.465	0.509	.	4.360	4.360	1.795	1.022	0.596	0.016	0.865	0.940	214	.	.	.	.	NAB2	143	0	148	36	0.195652173913043	TRUE	TRUE
ENSG00000155980.12	.	BCM	GRCh38.p13	chr12	57577759	57577759	+	C	C	A	Missense_Mutation	SNP	ENST00000455537.7	exon21	c.C2347A	p.L783M	exonic	ENSG00000155980.12	.	nonsynonymous SNV	ENSG00000155980.12:ENST00000455537.7:exon21:c.C2347A:p.L783M	12q13.3	C3L-01689	.	.	.	.	.	.	.	.	.	14.20	D	T	D	D	D	D	M	T	N	0.526	D	D	D	0.397	0.230	0.747	1.605	D	T	T	T	D	D	3.963	26.700	0.996	D	D	0.768	8.182	0.706	7.864	1.000	0.672	0.588	0.702	0.616	.	4.950	4.950	3.319	1.026	0.594	0.996	1.000	1.000	278	.	.	.	.	KIF5A	582	0	784	171	0.179057591623037	TRUE	TRUE
ENSG00000171435.14	.	BCM	GRCh38.p13	chr12	117761453	117761453	+	C	C	T	Missense_Mutation	SNP	ENST00000339824.7	exon4	c.G544A	p.V182M	exonic	ENSG00000171435.14	.	nonsynonymous SNV	ENSG00000171435.14:ENST00000339824.7:exon4:c.G544A:p.V182M	12q24.23	C3L-01689	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	N	T	N	0.255	T	T	T	0.197	0.243	0.562	0.686	T	T	T	T	T	D	2.257	21.300	0.996	D	D	-0.081	2.236	0.104	2.752	0.696	0.554	0.588	0.576	0.613	.	4.630	4.630	5.638	1.026	0.549	1.000	0.937	0.962	872	.	.	.	ID=COSV100348492;OCCURENCE=1(endometrium)	KSR2	369	0	450	91	0.168207024029575	TRUE	TRUE
ENSG00000166123.14	.	BCM	GRCh38.p13	chr16	46906859	46906859	+	C	C	T	Nonsense_Mutation	SNP	ENST00000340124.9	exon5	c.C460T	p.Q154X	exonic	ENSG00000166123.14	.	stopgain	ENSG00000166123.14:ENST00000340124.9:exon5:c.C460T:p.Q154X	16q11.2	C3L-01689	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.803	.	.	.	.	.	.	.	.	.	D	D	.	.	7.395	38	0.998	D	N	0.835	9.511	0.675	7.313	1.000	0.707	0.659	0.702	0.714	.	4.330	4.330	4.666	1.026	0.549	1.000	0.997	0.997	608	Aminotransferase,_class_I/classII	.	.	.	GPT2	183	0	296	76	0.204301075268817	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7676241	7676241	+	A	A	-	Nonsense_Mutation	SNP	ENST00000269305.8	exon4	c.128delT	p.L43*	exonic	ENSG00000141510.17	.	stopgain	ENSG00000141510.17:ENST00000269305.8:exon4:c.128delT:p.L43*	17p13.1	C3L-01689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	368	0	292	105	0.26448362720403	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11822861	11822861	+	A	A	G	Missense_Mutation	SNP	ENST00000262442.9	exon48	c.A9073G	p.T3025A	exonic	ENSG00000007174.18	.	nonsynonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon48:c.A9073G:p.T3025A	17p12	C3L-01689	.	.	.	.	.	.	.	.	.	0.19	T	.	B	B	N	N	N	T	N	0.118	T	T	T	0.011	0.289	0.182	0.086	T	T	T	T	T	T	0.972	11.280	0.802	N	N	-1.182	0.240	-1.115	0.361	0.000	0.554	0.574	0.602	0.564	.	4.060	0.584	0.620	0.318	-0.054	0.000	0.896	0.966	799	Dynein_heavy_chain,_AAA_module_D4	.	.	.	DNAH9	437	0	347	95	0.214932126696833	TRUE	TRUE
ENSG00000141068.14	.	BCM	GRCh38.p13	chr17	27588529	27588529	+	C	C	T	Missense_Mutation	SNP	ENST00000644974.1	exon6	c.C1040T	p.T347M	exonic	ENSG00000141068.14	.	nonsynonymous SNV	ENSG00000141068.14:ENST00000644974.1:exon6:c.C1040T:p.T347M	17q11.2	C3L-01689	0.0002	0	0	0.0006	0	0.0002	0	0	rs369066812	7.15	.	D	.	.	N	D	.	T	.	0.757	T	T	D	0.314	.	0.779	1.144	T	T	T	T	D	D	3.244	24.000	0.999	D	D	0.560	5.540	0.454	4.763	1.000	0.707	0.577	0.644	0.714	.	6.030	5.060	5.520	1.000	0.599	1.000	0.337	0.322	131	Protein_kinase_C-like,_phorbol_ester/diacylglycerol-binding_domain	.	.	ID=COSV52028611;OCCURENCE=1(large_intestine),1(prostate)	KSR1	87	0	131	23	0.149350649350649	TRUE	TRUE
ENSG00000277399.5	.	BCM	GRCh38.p13	chr17	38337666	38337666	+	G	G	A	Nonsense_Mutation	SNP	ENST00000616987.5	exon3	c.C958T	p.R320X	exonic	ENSG00000277399.5	.	stopgain	ENSG00000277399.5:ENST00000616987.5:exon3:c.C958T:p.R320X	17q12	C3L-01689	3.315e-05	0	0	0	0	4.5e-05	0	6.059e-05	rs768587459	4.6	.	.	.	.	N	A	.	.	.	0.102	.	.	.	.	.	.	.	.	.	D	D	.	.	6.839	36	0.998	D	N	0.518	5.178	0.382	4.230	0.987	0.487	0.574	0.547	0.530	.	5.120	4.150	2.514	0.218	-0.120	0.995	0.991	0.965	167	.	.	.	.	GPR179	215	0	266	56	0.173913043478261	TRUE	NA
ENSG00000181409.14	.	BCM	GRCh38.p13	chr17	81122398	81122398	+	G	G	A	Missense_Mutation	SNP	ENST00000326724.9	exon11	c.C1538T	p.P513L	exonic	ENSG00000181409.14	.	nonsynonymous SNV	ENSG00000181409.14:ENST00000326724.9:exon11:c.C1538T:p.P513L	17q25.3	C3L-01689	.	.	.	.	.	.	.	.	.	8.20	T	D	B	B	N	D	L	D	D	0.110	T	T	D	0.122	0.339	0.516	0.193	D	T	T	T	D	T	1.741	17.310	0.977	D	N	-0.130	2.082	-0.165	1.872	1.000	0.583	0.547	0.504	0.621	.	4.260	3.280	3.644	1.083	0.583	1.000	0.060	0.101	.	.	.	.	.	AATK	134	0	261	87	0.25	TRUE	NA
ENSG00000105641.4	.	BCM	GRCh38.p13	chr19	17881982	17881982	+	G	G	C	Missense_Mutation	SNP	ENST00000222248.4	exon9	c.G1081C	p.A361P	exonic	ENSG00000105641.4	.	nonsynonymous SNV	ENSG00000105641.4:ENST00000222248.4:exon9:c.G1081C:p.A361P	19p13.11	C3L-01689	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.934	D	D	D	0.895	0.843	0.995	0.509	T	T	D	D	D	D	3.742	25.600	0.998	D	D	0.702	7.147	0.553	5.684	1.000	0.646	0.547	0.645	0.613	.	4.360	4.360	4.218	1.065	0.656	1.000	0.898	0.605	940	.	.	.	.	SLC5A5	624	0	945	167	0.150179856115108	TRUE	TRUE
ENSG00000105388.16	.	BCM	GRCh38.p13	chr19	41721011	41721011	+	C	C	T	Missense_Mutation	SNP	ENST00000221992.11	exon8	c.C1861T	p.P621S	exonic	ENSG00000105388.16	.	nonsynonymous SNV	ENSG00000105388.16:ENST00000221992.11:exon8:c.C1861T:p.P621S	19q13.2	C3L-01689	.	.	.	.	.	.	.	.	.	2.16	T	D	.	.	.	N	.	T	N	0.404	T	T	T	0.109	0.734	0.571	0.782	T	T	T	T	T	D	2.457	22.300	0.996	N	N	0.075	2.788	-0.155	1.897	0.000	0.487	0.590	0.574	0.542	.	2.170	2.170	2.896	0.876	0.469	0.971	0.304	0.021	819	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	CEACAM5	525	0	694	187	0.212258796821793	TRUE	TRUE
ENSG00000278318.5	.	BCM	GRCh38.p13	chr19	44428745	44428745	+	G	G	A	Missense_Mutation	SNP	ENST00000614049.5	exon6	c.C2036T	p.T679M	exonic	ENSG00000278318.5	.	nonsynonymous SNV	ENSG00000278318.5:ENST00000614049.5:exon6:c.C2036T:p.T679M	19q13.31	C3L-01689	8.277e-06	0	0	0	0	1.498e-05	0	0	rs754516445	4.12	.	D	.	.	.	D	.	.	.	0.194	T	T	T	0.073	0.294	0.620	.	T	.	T	T	D	T	2.860	23.100	0.999	D	N	0.233	3.453	0.052	2.546	0.730	0.638	0.588	0.653	0.655	.	3.820	2.750	0.865	1.088	0.610	0.577	0.133	0.789	912	Zinc_finger_C2H2-type	.	.	ID=COSV52159418;OCCURENCE=4(oesophagus),1(large_intestine),1(central_nervous_system),1(pancreas),1(endometrium)	ZNF229	327	1	379	102	0.212058212058212	TRUE	TRUE
ENSG00000133265.11	.	BCM	GRCh38.p13	chr19	55277749	55277749	+	G	G	C	Missense_Mutation	SNP	ENST00000433386.7	exon3	c.C308G	p.P103R	exonic	ENSG00000133265.11	.	nonsynonymous SNV	ENSG00000133265.11:ENST00000433386.7:exon3:c.C308G:p.P103R	19q13.42	C3L-01689	.	.	.	.	.	.	.	.	.	2.16	T	D	.	.	N	N	.	T	N	0.581	T	T	T	0.079	.	0.491	0.443	T	T	T	T	T	T	3.103	23.600	0.998	D	.	0.070	2.771	0.138	2.897	1.000	0.745	0.686	0.732	0.714	.	4.530	4.530	2.745	1.176	0.676	0.573	0.701	0.836	988	Nucleotide_exchange_factor_Fes1	.	.	.	HSPBP1	150	0	220	45	0.169811320754717	TRUE	TRUE
ENSG00000173480.11	.	BCM	GRCh38.p13	chr19	57909397	57909397	+	G	G	A	Missense_Mutation	SNP	ENST00000312026.6	exon3	c.C881T	p.T294I	exonic	ENSG00000173480.11	.	nonsynonymous SNV	ENSG00000173480.11:ENST00000312026.6:exon3:c.C881T:p.T294I	19q13.43	C3L-01689	.	.	.	.	.	.	.	.	.	3.19	D	D	P	B	.	N	L	T	N	0.101	T	T	T	0.044	0.481	0.316	.	T	T	T	T	D	T	0.044	1.633	0.994	N	N	-0.939	0.473	-1.180	0.300	0.022	0.707	0.725	0.702	0.714	.	1.690	-3.380	-0.111	-2.125	-1.692	0.000	0.000	0.000	982	Zinc_finger_C2H2-type	.	.	.	ZNF417	450	0	470	115	0.196581196581197	NA	TRUE
ENSG00000078814.17	.	BCM	GRCh38.p13	chr20	34978030	34978030	+	G	G	A	Missense_Mutation	SNP	ENST00000618182.6	exon2	c.G148A	p.E50K	exonic	ENSG00000078814.17	.	nonsynonymous SNV	ENSG00000078814.17:ENST00000618182.6:exon2:c.G148A:p.E50K	20q11.22	C3L-01689	.	.	.	.	.	.	.	.	.	7.16	T	T	.	.	N	D	.	D	N	0.456	T	T	D	0.338	.	0.812	0.615	T	.	T	T	D	D	2.859	23.100	0.999	D	D	0.229	3.432	0.354	4.050	1.000	0.554	0.588	0.602	0.586	.	4.980	4.980	5.745	1.172	0.672	1.000	0.992	0.994	625	.	.	.	.	MYH7B	342	1	483	111	0.186868686868687	TRUE	TRUE
ENSG00000026559.14	.	BCM	GRCh38.p13	chr20	51004362	51004362	+	C	C	T	Missense_Mutation	SNP	ENST00000371571.5	exon3	c.G1219A	p.E407K	exonic	ENSG00000026559.14	.	nonsynonymous SNV	ENSG00000026559.14:ENST00000371571.5:exon3:c.G1219A:p.E407K	20q13.13	C3L-01689	.	.	.	.	.	.	.	.	.	8.20	T	T	D	P	N	D	N	T	N	0.524	T	T	D	0.225	0.502	0.742	2.611	D	T	T	T	D	D	3.382	24.400	0.995	D	D	0.359	4.100	0.427	4.557	1.000	0.718	0.590	0.571	0.586	.	5.490	4.550	7.860	1.022	0.596	1.000	1.000	1.000	846	Ion_transport_domain	.	.	.	KCNG1	176	0	313	52	0.142465753424658	TRUE	TRUE
ENSG00000026559.14	.	BCM	GRCh38.p13	chr20	51010206	51010206	+	G	G	A	Missense_Mutation	SNP	ENST00000371571.5	exon2	c.C133T	p.R45W	exonic	ENSG00000026559.14	.	nonsynonymous SNV	ENSG00000026559.14:ENST00000371571.5:exon2:c.C133T:p.R45W	20q13.13	C3L-01689	.	.	.	.	.	.	.	.	.	14.20	T	D	D	P	N	D	L	D	D	0.213	D	D	D	0.456	0.479	0.984	1.963	T	T	D	D	D	D	3.330	24.200	0.998	D	D	0.292	3.737	0.305	3.748	0.090	0.646	0.590	0.645	0.542	.	6.000	3.860	2.332	1.097	0.586	1.000	0.985	0.753	852	.	.	.	.	KCNG1	123	0	188	11	0.0552763819095477	TRUE	TRUE
ENSG00000077942.19	.	BCM	GRCh38.p13	chr22	45531286	45531286	+	A	A	G	Missense_Mutation	SNP	ENST00000327858.11	exon5	c.A506G	p.E169G	exonic	ENSG00000077942.19	.	nonsynonymous SNV	ENSG00000077942.19:ENST00000327858.11:exon5:c.A506G:p.E169G	22q13.31	C3L-01689	.	.	.	.	.	.	.	.	.	6.20	T	D	P	B	N	N	M	D	N	0.302	T	T	D	0.395	0.363	0.711	1.048	T	T	T	T	D	T	2.847	23.100	0.994	D	N	-0.067	2.281	-0.027	2.270	1.000	0.745	0.590	0.732	0.568	.	4.970	3.870	0.890	0.312	0.756	1.000	0.221	0.136	917	.	.	.	.	FBLN1	526	0	667	42	0.0592383638928068	TRUE	TRUE
ENSG00000183337.17	.	BCM	GRCh38.p13	chrX	40052396	40052396	+	G	G	A	Nonsense_Mutation	SNP	ENST00000378444.9	exon15	c.C4981T	p.R1661X	exonic	ENSG00000183337.17	.	stopgain	ENSG00000183337.17:ENST00000378444.9:exon15:c.C4981T:p.R1661X	Xp11.4	C3L-01689	.	.	.	.	.	.	.	.	.	5.5	.	.	.	.	.	D	.	.	.	0.941	.	.	.	.	.	.	.	.	.	D	D	D	.	7.202	37	0.997	D	.	.	.	.	.	1.000	.	.	.	.	.	5.500	4.620	1.984	1.175	0.676	0.980	0.904	0.969	912	BCL-6_corepressor,_PCGF1_binding_domain	.	.	ID=COSV60702852;OCCURENCE=2(haematopoietic_and_lymphoid_tissue)	BCOR	120	0	161	25	0.134408602150538	TRUE	TRUE
ENSG00000182872.16	.	BCM	GRCh38.p13	chrX	47185737	47185737	+	C	C	T	Nonsense_Mutation	SNP	ENST00000377604.8	exon21	c.C2377T	p.R793X	exonic	ENSG00000182872.16	.	stopgain	ENSG00000182872.16:ENST00000377604.8:exon21:c.C2377T:p.R793X	Xp11.3	C3L-01689	.	.	.	.	.	.	.	.	.	5.5	.	.	.	.	D	A	.	.	.	0.910	.	.	.	.	.	.	.	.	.	D	D	.	.	6.366	35	0.997	D	.	.	.	.	.	0.999	.	.	.	.	.	5.130	4.210	0.668	1.022	0.596	0.243	1.000	1.000	410	.	.	.	ID=COSV61307739;OCCURENCE=1(ovary),2(pancreas)	RBM10	397	0	411	191	0.317275747508306	TRUE	TRUE
ENSG00000112685.14	.	BCM	GRCh38.p13	chr6	564931	564931	+	T	T	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000112685.14	ENST00000230449.9:exon14:c.1444-2A>T	.	.	6p25.3	C3L-01689	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.989	35	0.995	D	.	1.141	19.539	1.000	18.853	1.000	0.106	0.097	0.126	0.110	0.968	5.700	5.700	5.571	1.138	0.665	1.000	1.000	0.999	888	.	.	.	.	EXOC2	185	1	222	19	0.0788381742738589	TRUE	TRUE
ENSG00000164402.14	.	BCM	GRCh38.p13	chr5	132761481	132761481	+	G	G	A	Silent	SNP	ENST00000378719.7	exon7	c.C939T	p.S313S	exonic	ENSG00000164402.14	.	synonymous SNV	ENSG00000164402.14:ENST00000378719.7:exon7:c.C939T:p.S313S	5q31.1	C3L-01689	3.342e-05	0	0	0	0	6.023e-05	0	0	rs370048462	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEPTIN8	124	0	175	43	0.197247706422018	TRUE	NA
ENSG00000154237.13	.	BCM	GRCh38.p13	chr15	101046063	101046063	+	A	A	C	Silent	SNP	ENST00000388948.8	exon21	c.A3046C	p.R1016R	exonic	ENSG00000154237.13	.	synonymous SNV	ENSG00000154237.13:ENST00000388948.8:exon21:c.A3046C:p.R1016R	15q26.3	C3L-01689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRRK1	388	0	529	104	0.164296998420221	TRUE	TRUE
ENSG00000153779.11	.	BCM	GRCh38.p13	chrX	89922148	89922148	+	G	G	A	Silent	SNP	ENST00000283891.6	exon2	c.G63A	p.A21A	exonic	ENSG00000153779.11	.	synonymous SNV	ENSG00000153779.11:ENST00000283891.6:exon2:c.G63A:p.A21A	Xq21.31	C3L-01689	0.0001	0.0010	0	0	0	0	0.0016	0	rs370716063	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52214586;OCCURENCE=1(lung),1(endometrium)	TGIF2LX	282	0	338	155	0.314401622718053	NA	TRUE
ENSG00000073111.14	.	BCM	GRCh38.p13	chr3	127610821	127610821	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000073111.14	.	.	.	3q21.3	C3L-01689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MCM2	446	1	654	126	0.161538461538462	TRUE	TRUE
ENSG00000165688.12	.	BCM	GRCh38.p13	chr9	136419178	136419178	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000165688.12	.	.	.	9q34.3	C3L-01689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PMPCA	165	0	288	66	0.186440677966102	TRUE	NA
ENSG00000166408.4	.	BCM	GRCh38.p13	chr11	7773061	7773061	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000166408.4	.	.	.	11p15.4	C3L-01689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR5P1P	248	0	321	25	0.0722543352601156	TRUE	NA
ENSG00000177359.20	.	BCM	GRCh38.p13	chr12	31206136	31206136	+	A	A	G	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000177359.20;ENSG00000270766.1	dist=4901;dist=38304	.	.	12p11.21	C3L-01689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC024940.2	212	0	325	18	0.0524781341107872	TRUE	NA
ENSG00000000457.14	.	BCM	GRCh38.p13	chr1	169868991	169868991	+	A	A	G	Missense_Mutation	SNP	ENST00000367772.8	exon7	c.T674C	p.L225S	exonic	ENSG00000000457.14	.	nonsynonymous SNV	ENSG00000000457.14:ENST00000367772.8:exon7:c.T674C:p.L225S	1q24.2	C3L-04027	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.907	D	D	D	0.764	0.804	0.755	0.880	T	T	D	D	D	T	4.095	27.700	0.999	D	D	0.768	8.180	0.749	8.778	0.981	0.707	0.725	0.576	0.636	.	5.800	5.800	6.544	1.312	0.756	1.000	0.995	0.998	548	Protein_kinase_domain	.	.	.	SCYL3	209	0	366	21	0.0542635658914729	TRUE	NA
ENSG00000211626.2	.	BCM	GRCh38.p13	chr2	90070214	90070214	+	C	C	A	Nonsense_Mutation	SNP	ENST00000390271.2	exon2	c.C321A	p.Y107X	exonic	ENSG00000211626.2	.	stopgain	ENSG00000211626.2:ENST00000390271.2:exon2:c.C321A:p.Y107X	2p11.2	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGKV6D-41	231	0	319	20	0.0589970501474926	TRUE	TRUE
ENSG00000074047.21	.	BCM	GRCh38.p13	chr2	120975086	120975086	+	G	G	A	Missense_Mutation	SNP	ENST00000452319.5	exon9	c.G1345A	p.D449N	exonic	ENSG00000074047.21	.	nonsynonymous SNV	ENSG00000074047.21:ENST00000452319.5:exon9:c.G1345A:p.D449N	2q14.2	C3L-04027	0.0001	0	0	0	0	0.0003	0	0	rs13427953	13.20	D	D	D	D	D	D	M	T	D	0.660	T	T	T	0.254	.	0.716	1.045	T	D	T	T	D	D	4.275	29.400	0.999	D	D	0.656	6.551	0.704	7.825	1.000	0.635	0.574	0.644	0.613	.	5.200	5.200	10.003	1.176	0.676	1.000	0.815	0.959	692	Zinc_finger_C2H2-type	.	.	ID=COSV58051466;OCCURENCE=3(skin),1(upper_aerodigestive_tract)	GLI2	242	0	450	39	0.0797546012269939	TRUE	TRUE
ENSG00000012223.13	.	BCM	GRCh38.p13	chr3	46448997	46448997	+	G	G	A	Missense_Mutation	SNP	ENST00000231751.9	exon9	c.C1078T	p.R360W	exonic	ENSG00000012223.13	.	nonsynonymous SNV	ENSG00000012223.13:ENST00000231751.9:exon9:c.C1078T:p.R360W	3p21.31	C3L-04027	0.0003	0	0.0004	0.0001	0	0.0004	0	6.385e-05	rs144305401	8.20	D	D	D	D	N	N	M	T	D	0.455	T	T	T	0.135	.	0.541	0.353	T	D	T	T	T	D	1.902	18.510	0.998	N	N	-0.193	1.895	-0.459	1.269	0.993	0.554	0.563	0.602	0.542	.	3.670	1.820	-0.240	0.227	0.676	0.000	0.002	0.019	422	Transferrin-like_domain	.	.	ID=COSV51610253;OCCURENCE=1(pancreas)	LTF	141	0	316	31	0.0893371757925072	TRUE	TRUE
ENSG00000168386.18	.	BCM	GRCh38.p13	chr3	99850112	99850112	+	A	A	C	Missense_Mutation	SNP	ENST00000354552.7	exon5	c.T1564G	p.S522A	exonic	ENSG00000168386.18	.	nonsynonymous SNV	ENSG00000168386.18:ENST00000354552.7:exon5:c.T1564G:p.S522A	3q12.1	C3L-04027	0.0006	0.0022	0.0005	0.0002	0	0.0001	0	0.0022	rs201193835	0.20	T	T	B	B	N	N	N	T	N	0.112	T	T	T	0.109	.	0.061	0.053	T	T	T	T	T	T	-0.573	0.083	0.680	N	N	-2.098	0.006	-2.093	0.008	1.000	0.707	0.588	0.547	0.714	.	5.650	-11.300	-0.206	-2.560	-1.432	0.603	0.008	0.414	445	.	.	.	.	FILIP1L	118	0	244	15	0.0579150579150579	TRUE	NA
ENSG00000138246.17	.	BCM	GRCh38.p13	chr3	132503260	132503260	+	G	G	A	Missense_Mutation	SNP	ENST00000260818.11	exon41	c.G4763A	p.R1588H	exonic	ENSG00000138246.17	.	nonsynonymous SNV	ENSG00000138246.17:ENST00000260818.11:exon41:c.G4763A:p.R1588H	3q22.1	C3L-04027	7.418e-05	0.0006	8.651e-05	0	0	2.998e-05	0	0	rs145101163	12.20	D	D	D	D	D	D	M	T	D	0.688	T	T	T	0.308	.	0.330	0.410	T	T	T	T	D	D	3.803	25.800	0.999	D	D	0.843	9.672	0.822	10.803	1.000	0.732	0.725	0.744	0.714	.	5.500	5.500	9.441	1.176	0.676	1.000	0.998	0.987	824	.	.	.	ID=COSV53454491;OCCURENCE=1(endometrium)	DNAJC13	202	0	341	21	0.0580110497237569	TRUE	TRUE
ENSG00000124279.12	.	BCM	GRCh38.p13	chr5	7866727	7866727	+	G	G	A	Missense_Mutation	SNP	ENST00000264669.10	exon2	c.C1357T	p.H453Y	exonic	ENSG00000124279.12	.	nonsynonymous SNV	ENSG00000124279.12:ENST00000264669.10:exon2:c.C1357T:p.H453Y	5p15.31	C3L-04027	.	.	.	.	.	.	.	.	.	8.20	T	T	P	P	D	D	M	T	N	0.763	T	T	T	0.290	0.694	0.703	0.775	T	T	D	D	D	T	3.446	24.500	0.997	D	D	0.400	4.344	0.412	4.447	1.000	0.651	0.659	0.659	0.684	.	4.950	4.950	5.983	1.176	0.676	1.000	0.986	0.987	735	FAST_kinase_leucine-rich	.	.	.	FASTKD3	102	0	166	12	0.0674157303370786	TRUE	TRUE
ENSG00000178394.5	.	BCM	GRCh38.p13	chr5	63961040	63961040	+	C	C	T	Missense_Mutation	SNP	ENST00000323865.5	exon1	c.G680A	p.R227H	exonic	ENSG00000178394.5	.	nonsynonymous SNV	ENSG00000178394.5:ENST00000323865.5:exon1:c.G680A:p.R227H	5q12.3	C3L-04027	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.734	T	T	D	0.296	0.624	0.650	1.826	T	D	D	T	D	D	4.009	27.000	0.999	D	D	0.755	7.959	0.721	8.162	1.000	0.726	0.547	0.594	0.530	.	5.700	5.700	3.383	1.026	0.599	1.000	0.939	0.929	828	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV60500218;OCCURENCE=1(large_intestine),1(ovary),1(stomach),1(endometrium)	HTR1A	682	0	1057	74	0.0654288240495137	TRUE	TRUE
ENSG00000164197.12	.	BCM	GRCh38.p13	chr5	64325233	64325233	+	A	A	C	Missense_Mutation	SNP	ENST00000389100.9	exon6	c.A1275C	p.E425D	exonic	ENSG00000164197.12	.	nonsynonymous SNV	ENSG00000164197.12:ENST00000389100.9:exon6:c.A1275C:p.E425D	5q12.3	C3L-04027	.	.	.	.	.	.	.	.	.	3.20	T	T	P	P	N	N	M	T	N	0.127	T	T	T	0.107	0.319	0.757	0.032	T	T	T	T	D	T	1.448	15.400	0.995	D	N	-0.112	2.137	-0.146	1.921	0.000	0.554	0.574	0.602	0.621	.	5.350	-0.965	0.150	0.316	0.743	0.954	1.000	1.000	720	.	.	.	ID=COSV66633903;OCCURENCE=1(oesophagus),2(stomach)	RNF180	306	0	471	27	0.0542168674698795	TRUE	TRUE
ENSG00000145808.10	.	BCM	GRCh38.p13	chr5	129641937	129641937	+	G	G	A	Missense_Mutation	SNP	ENST00000274487.9	exon11	c.G1849A	p.G617R	exonic	ENSG00000145808.10	.	nonsynonymous SNV	ENSG00000145808.10:ENST00000274487.9:exon11:c.G1849A:p.G617R	5q23.3	C3L-04027	.	.	.	.	.	.	.	.	.	16.19	D	.	D	D	D	D	H	T	N	.	D	D	D	0.687	0.573	0.582	0.770	T	D	D	D	D	D	4.427	31	0.999	D	D	0.829	9.385	0.727	8.289	0.972	0.706	0.574	0.710	0.564	.	4.020	4.020	6.903	1.176	0.618	1.000	1.000	0.998	629	ADAM,_cysteine-rich	.	.	.	ADAMTS19	70	0	124	7	0.0534351145038168	TRUE	NA
ENSG00000112249.14	.	BCM	GRCh38.p13	chr6	100589761	100589761	+	C	C	T	Missense_Mutation	SNP	ENST00000369162.7	exon36	c.G5423A	p.R1808H	exonic	ENSG00000112249.14	.	nonsynonymous SNV	ENSG00000112249.14:ENST00000369162.7:exon36:c.G5423A:p.R1808H	6q16.3	C3L-04027	5.782e-05	0	0.0003	0	0	6.008e-05	0	0	rs371661297	6.20	T	T	D	P	D	D	L	T	N	0.657	T	T	T	0.145	0.486	0.525	0.682	T	T	T	T	T	D	3.438	24.500	0.998	D	D	0.589	5.815	0.595	6.167	1.000	0.706	0.725	0.659	0.613	.	5.220	5.220	4.298	1.026	0.549	1.000	0.999	0.995	928	.	.	.	.	ASCC3	390	0	527	41	0.0721830985915493	TRUE	NA
ENSG00000154997.9	.	BCM	GRCh38.p13	chr7	55846517	55846517	+	C	C	A	Missense_Mutation	SNP	ENST00000388975.4	exon3	c.G175T	p.G59W	exonic	ENSG00000154997.9	.	nonsynonymous SNV	ENSG00000154997.9:ENST00000388975.4:exon3:c.G175T:p.G59W	7p11.2	C3L-04027	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	N	D	H	D	D	0.971	D	D	D	0.831	0.961	0.956	0.470	T	T	D	D	D	D	5.310	33	0.993	D	D	0.922	11.621	0.758	8.982	1.000	0.554	0.574	0.547	0.621	.	4.400	4.400	6.670	0.634	0.587	1.000	0.886	0.909	835	Septin-type_guanine_nucleotide-binding_(G)_domain	.	.	ID=COSV66425881;OCCURENCE=1(large_intestine)	SEPTIN14	82	0	181	14	0.0717948717948718	NA	TRUE
ENSG00000187391.21	.	BCM	GRCh38.p13	chr7	79453128	79453128	+	G	G	C	Missense_Mutation	SNP	ENST00000354212.9	exon1	c.C193G	p.L65V	exonic	ENSG00000187391.21	.	nonsynonymous SNV	ENSG00000187391.21:ENST00000354212.9:exon1:c.C193G:p.L65V	7q21.11	C3L-04027	.	.	.	.	.	.	.	.	.	7.19	T	T	D	D	.	D	L	T	N	0.666	T	T	T	0.104	0.441	0.790	1.959	T	T	T	T	D	D	3.306	24.100	0.957	D	D	0.335	3.966	0.429	4.568	1.000	0.437	0.590	0.607	0.250	.	5.390	5.390	5.605	1.088	0.617	1.000	0.999	0.997	948	PDZ_domain	.	.	.	MAGI2	142	0	316	21	0.0623145400593472	TRUE	TRUE
ENSG00000147485.13	.	BCM	GRCh38.p13	chr8	51320784	51320784	+	C	C	A	Missense_Mutation	SNP	ENST00000356297.5	exon22	c.G4260T	p.E1420D	exonic	ENSG00000147485.13	.	nonsynonymous SNV	ENSG00000147485.13:ENST00000356297.5:exon22:c.G4260T:p.E1420D	8q11.22	C3L-04027	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	.	D	N	T	N	0.138	T	T	T	0.084	0.359	0.390	0.163	T	T	T	T	T	T	3.443	24.500	0.787	D	N	0.023	2.596	-0.036	2.239	0.001	0.554	0.574	0.618	0.564	.	4.370	4.370	1.628	0.789	0.599	1.000	0.021	0.026	900	VWFC_domain	.	.	.	PXDNL	215	0	350	32	0.0837696335078534	TRUE	TRUE
ENSG00000182752.10	.	BCM	GRCh38.p13	chr9	116235355	116235355	+	A	A	C	Missense_Mutation	SNP	ENST00000328252.4	exon7	c.A2450C	p.K817T	exonic	ENSG00000182752.10	.	nonsynonymous SNV	ENSG00000182752.10:ENST00000328252.4:exon7:c.A2450C:p.K817T	9q33.1	C3L-04027	.	.	.	.	.	.	.	.	.	8.20	T	T	D	P	D	D	M	T	N	0.222	T	T	T	0.191	0.562	0.110	0.714	T	T	T	T	D	D	3.077	23.600	0.994	D	D	0.518	5.179	0.583	6.022	1.000	0.487	0.563	0.574	0.564	.	6.040	6.040	5.753	1.312	0.756	1.000	0.999	0.990	448	.	.	.	.	PAPPA	289	0	421	31	0.0685840707964602	TRUE	TRUE
ENSG00000136854.22	.	BCM	GRCh38.p13	chr9	127682465	127682465	+	G	G	A	Missense_Mutation	SNP	ENST00000373299.5	exon18	c.G1607A	p.R536H	exonic	ENSG00000136854.22	.	nonsynonymous SNV	ENSG00000136854.22:ENST00000373299.5:exon18:c.G1607A:p.R536H	9q34.11	C3L-04027	8.259e-06	0	0	0	0	1.504e-05	0	0	rs749244650	19.20	D	D	D	D	D	D	M	T	D	0.961	D	D	D	0.864	0.617	0.783	2.597	D	D	D	D	D	D	4.568	32	1.000	D	D	1.082	16.781	1.007	19.298	1.000	0.707	0.610	0.725	0.714	.	5.620	5.620	9.859	1.176	0.676	1.000	0.999	0.996	305	.	.	.	.	STXBP1	523	2	931	61	0.061491935483871	TRUE	NA
ENSG00000172538.7	.	BCM	GRCh38.p13	chr10	49132002	49132002	+	C	C	A	Nonsense_Mutation	SNP	ENST00000311787.6	exon2	c.G463T	p.E155X	exonic	ENSG00000172538.7	.	stopgain	ENSG00000172538.7:ENST00000311787.6:exon2:c.G463T:p.E155X	10q11.23	C3L-04027	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	D	.	.	.	0.063	.	.	.	.	.	.	.	.	.	D	D	.	.	6.538	36	0.997	N	N	0.565	5.582	0.363	4.106	1.000	0.497	0.547	0.547	0.542	.	5.630	4.730	0.634	0.019	-0.197	0.434	0.974	0.777	.	.	.	.	.	FAM170B	380	0	665	54	0.0751043115438109	TRUE	TRUE
ENSG00000225830.14	.	BCM	GRCh38.p13	chr10	49482809	49482809	+	G	G	A	Nonsense_Mutation	SNP	ENST00000355832.10	exon10	c.C2047T	p.R683X	exonic	ENSG00000225830.14	.	stopgain	ENSG00000225830.14:ENST00000355832.10:exon10:c.C2047T:p.R683X	10q11.23	C3L-04027	3.296e-05	0	0	0.0001	0	4.497e-05	0	0	rs121917904	4.5	.	.	.	.	.	A	.	.	.	0.963	.	.	.	.	.	.	.	.	.	D	D	.	.	8.420	43	0.998	D	N	0.925	11.728	0.807	10.323	1.000	0.707	0.654	0.653	0.714	.	5.680	4.710	5.688	1.176	0.676	1.000	1.000	0.984	828	Helicase_superfamily_1/2,_ATP-binding_domain;SNF2-related,_N-terminal_domain	.	.	.	ERCC6	338	0	566	38	0.0629139072847682	TRUE	NA
ENSG00000134812.8	.	BCM	GRCh38.p13	chr11	59831740	59831740	+	G	G	A	Missense_Mutation	SNP	ENST00000257248.3	exon8	c.C1130T	p.A377V	exonic	ENSG00000134812.8	.	nonsynonymous SNV	ENSG00000134812.8:ENST00000257248.3:exon8:c.C1130T:p.A377V	11q12.1	C3L-04027	9.062e-05	9.61e-05	0.0002	0.0001	0	0.0001	0	0	rs370902375	0.16	T	T	.	.	N	N	.	T	N	0.515	T	T	T	0.064	.	0.376	0.128	T	.	T	T	T	T	2.541	22.500	0.921	N	N	0.061	2.736	0.121	2.822	0.000	0.487	0.574	0.574	0.564	.	5.410	4.410	1.707	1.158	0.654	0.472	0.925	0.898	799	Domain_of_unknown_function_DUF4430	.	.	ID=COSV57238166;OCCURENCE=1(pancreas),1(upper_aerodigestive_tract)	CBLIF	409	1	674	62	0.0842391304347826	TRUE	TRUE
ENSG00000162144.10	.	BCM	GRCh38.p13	chr11	61353957	61353957	+	C	C	T	Missense_Mutation	SNP	ENST00000294072.9	exon4	c.G220A	p.G74R	exonic	ENSG00000162144.10	.	nonsynonymous SNV	ENSG00000162144.10:ENST00000294072.9:exon4:c.G220A:p.G74R	11q12.2	C3L-04027	.	.	.	.	.	.	.	.	.	8.20	T	T	D	D	N	D	M	T	N	0.298	T	T	T	0.150	0.385	0.439	1.324	T	T	T	T	D	D	3.035	23.500	0.999	D	D	0.587	5.799	0.586	6.048	1.000	0.707	0.686	0.644	0.714	.	5.780	5.780	3.033	1.025	0.599	0.906	0.984	0.923	756	Cytochrome_b561/ferric_reductase_transmembrane	.	.	.	CYB561A3	362	0	615	42	0.0639269406392694	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-04027	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	313	0	604	136	0.183783783783784	TRUE	TRUE
ENSG00000173064.13	.	BCM	GRCh38.p13	chr12	112283262	112283262	+	C	C	T	Missense_Mutation	SNP	ENST00000377560.9	exon8	c.G1376A	p.R459H	exonic	ENSG00000173064.13	.	nonsynonymous SNV	ENSG00000173064.13:ENST00000377560.9:exon8:c.G1376A:p.R459H	12q24.13	C3L-04027	6.843e-05	0	0.0003	0.0001	0	4.614e-05	0	6.427e-05	rs544019388	8.16	D	D	.	.	.	D	.	T	N	0.775	T	T	D	0.316	.	0.139	1.267	T	T	T	D	T	D	3.891	26.300	0.999	D	D	0.648	6.449	0.702	7.794	1.000	0.651	0.654	0.659	0.684	.	5.570	5.570	7.539	1.026	0.599	1.000	1.000	0.992	69	.	.	.	.	HECTD4	182	0	269	15	0.0528169014084507	TRUE	NA
ENSG00000197653.16	.	BCM	GRCh38.p13	chr12	123903025	123903025	+	G	G	A	Missense_Mutation	SNP	ENST00000638045.1	exon56	c.G9373A	p.E3125K	exonic	ENSG00000197653.16	.	nonsynonymous SNV	ENSG00000197653.16:ENST00000638045.1:exon56:c.G9373A:p.E3125K	12q24.31	C3L-04027	4.418e-05	0	0	0	0	5.157e-05	0	9.489e-05	rs757406131	13.16	.	.	D	P	D	D	M	.	.	.	D	D	D	0.635	0.389	0.572	0.340	T	T	D	D	D	D	3.159	23.800	0.999	D	D	0.556	5.501	0.527	5.414	1.000	0.497	0.590	0.547	0.542	.	5.910	5.020	9.941	1.176	0.676	1.000	0.235	0.150	721	Dynein_heavy_chain,_coiled_coil_stalk	.	.	.	DNAH10	178	0	290	19	0.0614886731391586	TRUE	NA
ENSG00000133110.15	.	BCM	GRCh38.p13	chr13	37586796	37586796	+	G	G	C	Missense_Mutation	SNP	ENST00000379747.9	exon6	c.C739G	p.L247V	exonic	ENSG00000133110.15	.	nonsynonymous SNV	ENSG00000133110.15:ENST00000379747.9:exon6:c.C739G:p.L247V	13q13.3	C3L-04027	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	N	0.337	D	D	D	0.706	0.601	0.947	0.245	T	D	D	D	D	D	3.369	24.300	0.998	D	D	0.758	8.019	0.705	7.849	1.000	0.554	0.574	0.618	0.621	.	5.560	5.560	3.013	1.155	0.676	1.000	0.699	0.971	476	FAS1_domain	.	.	.	POSTN	195	0	297	25	0.077639751552795	TRUE	TRUE
ENSG00000150893.11	.	BCM	GRCh38.p13	chr13	38856205	38856205	+	G	G	C	Missense_Mutation	SNP	ENST00000280481.9	exon12	c.G7005C	p.E2335D	exonic	ENSG00000150893.11	.	nonsynonymous SNV	ENSG00000150893.11:ENST00000280481.9:exon12:c.G7005C:p.E2335D	13q13.3	C3L-04027	.	.	.	.	.	.	.	.	.	9.15	D	D	.	.	D	D	.	T	N	0.946	T	T	D	0.559	0.684	0.551	0.539	T	.	D	D	D	.	2.848	23.100	0.998	D	N	0.002	2.520	-0.136	1.948	0.114	0.706	0.624	0.710	0.564	.	5.790	1.080	0.466	-1.109	-0.682	0.998	0.982	0.986	934	.	.	.	.	FREM2	509	1	901	55	0.0575313807531381	TRUE	TRUE
ENSG00000100505.13	.	BCM	GRCh38.p13	chr14	51010485	51010485	+	C	C	T	Missense_Mutation	SNP	ENST00000298355.7	exon4	c.G1051A	p.D351N	exonic	ENSG00000100505.13	.	nonsynonymous SNV	ENSG00000100505.13:ENST00000298355.7:exon4:c.G1051A:p.D351N	14q22.1	C3L-04027	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	D	0.706	T	D	D	0.275	0.627	0.681	0.897	D	T	T	T	D	D	3.511	24.700	0.999	D	D	0.770	8.218	0.795	9.981	1.000	0.638	0.590	0.653	0.530	.	5.870	5.870	7.905	1.026	0.599	1.000	0.994	0.986	438	B-box,_C-terminal	.	.	.	TRIM9	201	0	392	27	0.0644391408114559	TRUE	TRUE
ENSG00000186469.8	.	BCM	GRCh38.p13	chr14	51950754	51950754	+	G	G	A	Missense_Mutation	SNP	ENST00000335281.8	exon2	c.G76A	p.D26N	exonic	ENSG00000186469.8	.	nonsynonymous SNV	ENSG00000186469.8:ENST00000335281.8:exon2:c.G76A:p.D26N	14q22.1	C3L-04027	2.511e-05	0	0	0	0	0	0	0.0002	rs771997787	12.19	D	D	D	B	D	D	.	T	D	0.795	T	T	D	0.147	0.415	0.390	2.040	D	T	T	T	D	D	3.102	23.600	0.999	D	D	0.516	5.162	0.574	5.913	1.000	0.719	0.723	0.725	0.530	.	5.030	5.030	9.346	1.176	0.671	1.000	0.986	0.996	896	G-protein_gamma-like_domain	.	.	.	GNG2	66	0	133	14	0.0952380952380952	TRUE	NA
ENSG00000007376.8	.	BCM	GRCh38.p13	chr16	786374	786374	+	C	C	T	Missense_Mutation	SNP	ENST00000007264.7	exon6	c.G515A	p.R172Q	exonic	ENSG00000007376.8	.	nonsynonymous SNV	ENSG00000007376.8:ENST00000007264.7:exon6:c.G515A:p.R172Q	16p13.3	C3L-04027	8.976e-06	0	8.868e-05	0	0	0	0	0	rs761438615	16.20	D	D	D	D	D	D	H	T	D	0.955	D	T	D	0.652	0.919	0.643	0.485	T	T	D	D	D	D	3.984	26.900	0.999	D	D	0.845	9.717	0.669	7.203	1.000	0.707	0.702	0.723	0.714	.	3.880	3.880	7.595	1.022	0.596	1.000	0.961	0.363	745	Pseudouridine_synthase,_RsuA/RluB/C/D/E/F	.	.	ID=COSV50101217;OCCURENCE=1(large_intestine)	RPUSD1	98	0	166	12	0.0674157303370786	TRUE	TRUE
ENSG00000168140.5	.	BCM	GRCh38.p13	chr16	4381565	4381565	+	C	C	T	Nonsense_Mutation	SNP	ENST00000304735.4	exon2	c.C688T	p.R230X	exonic	ENSG00000168140.5	.	stopgain	ENSG00000168140.5:ENST00000304735.4:exon2:c.C688T:p.R230X	16p13.3	C3L-04027	1.631e-05	0	0	0	0	2.948e-05	0	0	rs766706462	3.6	.	.	.	.	N	D	.	.	.	0.042	.	.	.	.	.	.	.	.	.	D	D	.	.	6.905	36	0.996	N	N	0.374	4.186	0.120	2.818	1.000	0.696	0.380	0.723	0.492	.	5.690	3.610	0.470	1.022	0.596	0.069	0.569	0.320	580	.	.	.	.	VASN	328	0	578	44	0.0707395498392283	TRUE	NA
ENSG00000183921.7	.	BCM	GRCh38.p13	chr16	22181550	22181550	+	G	G	A	Missense_Mutation	SNP	ENST00000602312.2	exon8	c.G704A	p.R235Q	exonic	ENSG00000183921.7	.	nonsynonymous SNV	ENSG00000183921.7:ENST00000602312.2:exon8:c.G704A:p.R235Q	16p12.2	C3L-04027	.	.	.	.	.	.	.	.	rs1027761752	3.10	.	T	.	.	N	.	.	.	.	0.144	T	T	.	0.343	.	0.178	.	.	T	T	T	D	.	3.369	24.300	0.999	D	D	0.210	3.348	0.298	3.705	0.999	0.554	0.588	0.602	0.542	.	5.440	4.290	3.906	0.225	0.618	1.000	0.993	0.993	527	3-beta_hydroxysteroid_dehydrogenase/isomerase	.	.	.	SDR42E2	255	1	497	37	0.0692883895131086	TRUE	NA
ENSG00000121281.13	.	BCM	GRCh38.p13	chr16	50293442	50293442	+	G	G	A	Missense_Mutation	SNP	ENST00000673801.1	exon6	c.G776A	p.R259H	exonic	ENSG00000121281.13	.	nonsynonymous SNV	ENSG00000121281.13:ENST00000673801.1:exon6:c.G776A:p.R259H	16q12.1	C3L-04027	6.601e-05	0	0.0003	0.0001	0	3.004e-05	0	0.0001	rs545059286	4.20	T	T	B	B	U	D	L	D	N	0.229	T	T	D	0.207	.	0.829	0.575	T	T	T	T	T	T	1.776	17.560	0.994	D	N	-0.264	1.705	-0.167	1.867	1.000	0.672	0.702	0.645	0.655	.	5.180	4.160	1.937	0.224	0.676	0.955	0.059	0.017	767	Adenylyl_cyclase_class-3/4/guanylyl_cyclase	.	.	ID=COSV54271135;OCCURENCE=1(oesophagus),1(large_intestine),1(central_nervous_system)	ADCY7	252	0	511	32	0.0589318600368324	TRUE	TRUE
ENSG00000159387.8	.	BCM	GRCh38.p13	chr16	55327368	55327368	+	C	C	T	Missense_Mutation	SNP	ENST00000290552.8	exon3	c.C376T	p.P126S	exonic	ENSG00000159387.8	.	nonsynonymous SNV	ENSG00000159387.8:ENST00000290552.8:exon3:c.C376T:p.P126S	16q12.2	C3L-04027	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	N	D	L	D	D	0.275	T	D	D	0.206	0.359	0.858	0.103	T	T	T	T	T	D	1.311	14.460	0.980	D	N	-0.619	0.953	-0.586	1.068	0.305	0.598	0.590	0.596	0.530	.	5.490	-0.191	0.752	-0.405	-0.202	0.223	0.931	0.984	884	.	.	.	ID=COSV51862486;OCCURENCE=1(skin)	IRX6	253	0	457	31	0.0635245901639344	TRUE	TRUE
ENSG00000159398.16	.	BCM	GRCh38.p13	chr16	55846602	55846602	+	C	C	T	Missense_Mutation	SNP	ENST00000290567.14	exon13	c.G1577A	p.S526N	exonic	ENSG00000159398.16	.	nonsynonymous SNV	ENSG00000159398.16:ENST00000290567.14:exon13:c.G1577A:p.S526N	16q12.2	C3L-04027	.	.	.	.	.	.	.	.	.	2.20	T	T	P	P	N	N	M	T	N	0.140	T	T	D	0.101	0.354	0.081	0.217	T	T	T	T	T	T	1.392	15.030	0.978	N	N	-0.310	1.590	-0.521	1.168	0.999	0.487	0.590	0.547	0.564	.	5.510	-0.144	0.150	1.018	0.599	0.001	0.014	0.112	929	Carboxylesterase,_type_B	.	.	.	CES5A	525	0	886	67	0.0703043022035677	TRUE	TRUE
ENSG00000225614.4	.	BCM	GRCh38.p13	chr16	88438454	88438454	+	C	C	T	Nonsense_Mutation	SNP	ENST00000565624.3	exon3	c.C10984T	p.R3662X	exonic	ENSG00000225614.4	.	stopgain	ENSG00000225614.4:ENST00000565624.3:exon3:c.C10984T:p.R3662X	16q24.2	C3L-04027	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	D	.	.	.	0.472	.	.	.	.	.	.	.	.	.	D	D	.	.	7.434	38	0.979	N	N	-0.019	2.446	-0.380	1.408	0.817	0.646	0.588	0.645	0.700	.	4.650	1.430	0.600	-0.157	-0.694	0.000	0.000	0.000	.	.	.	.	.	ZNF469	272	0	494	26	0.05	TRUE	NA
ENSG00000132535.21	.	BCM	GRCh38.p13	chr17	7196902	7196902	+	C	C	T	Missense_Mutation	SNP	ENST00000399506.9	exon9	c.G938A	p.R313Q	exonic	ENSG00000132535.21	.	nonsynonymous SNV	ENSG00000132535.21:ENST00000399506.9:exon9:c.G938A:p.R313Q	17p13.1	C3L-04027	1.704e-05	0	0.0002	0	0	0	0	0	rs764739020	5.19	T	T	D	D	.	D	L	T	N	0.282	T	T	T	0.157	0.579	0.799	1.889	T	T	T	T	D	D	3.203	23.900	0.999	N	N	0.114	2.941	0.128	2.851	0.962	0.707	0.634	0.725	0.714	.	5.280	5.280	0.885	1.026	0.599	0.009	0.999	0.999	498	PDZ_domain	.	.	ID=COSV57238233;OCCURENCE=3(large_intestine),1(endometrium)	DLG4	410	1	676	57	0.077762619372442	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675085	7675085	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G527A	p.C176Y	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G527A:p.C176Y	17p13.1	C3L-04027	.	.	.	.	.	.	.	.	rs786202962	20.20	D	D	D	D	D	D	M	D	D	0.977	D	D	D	0.949	0.961	0.986	2.143	D	D	D	D	D	D	4.061	27.400	0.997	D	D	0.857	10.008	0.769	9.258	1.000	0.722	0.698	0.698	0.735	.	5.590	4.610	7.905	1.026	0.599	1.000	0.999	0.932	434	p53,_DNA-binding_domain	.	.	ID=COSV52660760;OCCURENCE=1(salivary_gland),8(breast),9(liver),16(oesophagus),29(large_intestine),8(central_nervous_system),3(biliary_tract),7(ovary),2(bone),1(NS),19(haematopoietic_and_lymphoid_tissue),5(stomach),1(urinary_tract),3(pancreas),2(skin),15(lung),9(upper_aerodigestive_tract),1(thymus),5(endometrium)	TP53	440	1	696	47	0.063257065948856	TRUE	TRUE
ENSG00000007171.18	.	BCM	GRCh38.p13	chr17	27765558	27765558	+	C	C	T	Missense_Mutation	SNP	ENST00000313735.11	exon20	c.G2405A	p.R802H	exonic	ENSG00000007171.18	.	nonsynonymous SNV	ENSG00000007171.18:ENST00000313735.11:exon20:c.G2405A:p.R802H	17q11.2	C3L-04027	1.75e-05	0	0	0	0	0	0	0.0001	rs774982047	1.20	T	T	B	B	N	N	L	T	D	0.207	T	T	T	0.041	0.378	0.401	0.198	T	T	T	T	T	T	-0.023	1.197	0.974	N	N	-1.119	0.290	-1.171	0.308	0.000	0.447	0.563	0.547	0.613	.	5.190	-2.000	0.185	-2.551	-2.750	0.187	0.002	0.027	185	Sulfite_reductase_[NADPH]_flavoprotein_alpha-component-like,_FAD-binding;FAD-binding_domain,_ferredoxin_reductase-type	.	.	ID=COSV58223772;OCCURENCE=2(breast)	NOS2	119	1	211	13	0.0580357142857143	TRUE	TRUE
ENSG00000108375.12	.	BCM	GRCh38.p13	chr17	58358637	58358643	+	TCCTGGG	TCCTGGG	-	Frame_Shift_Del	DEL	ENST00000584437.5	exon8	c.1133_1139del	p.S378Cfs*39	exonic	ENSG00000108375.12;ENSG00000285897.1	.	frameshift deletion	ENSG00000108375.12:ENST00000584437.5:exon8:c.1133_1139del:p.S378Cfs*39,ENSG00000285897.1:ENST00000648873.1:exon8:c.1133_1139del:p.S378Cfs*39	17q22	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF43	56	0	83	16	0.161616161616162	TRUE	TRUE
ENSG00000171804.11	.	BCM	GRCh38.p13	chr19	37895101	37895101	+	A	A	T	Missense_Mutation	SNP	ENST00000447313.7	exon4	c.T602A	p.I201N	exonic	ENSG00000171804.11	.	nonsynonymous SNV	ENSG00000171804.11:ENST00000447313.7:exon4:c.T602A:p.I201N	19q13.13	C3L-04027	.	.	.	.	.	.	.	.	.	11.18	D	D	D	D	N	N	.	T	D	0.781	D	D	D	0.593	0.655	0.432	.	T	.	D	T	D	T	3.559	24.900	0.957	D	N	0.514	5.143	0.457	4.787	0.999	0.497	0.590	0.547	0.542	.	5.770	5.770	5.370	1.312	0.743	0.990	0.406	0.087	646	.	.	.	.	WDR87	367	0	601	39	0.0609375	TRUE	TRUE
ENSG00000203326.12	.	BCM	GRCh38.p13	chr19	53375873	53375873	+	A	A	T	Missense_Mutation	SNP	ENST00000474037.6	exon3	c.A119T	p.N40I	exonic	ENSG00000203326.12	.	nonsynonymous SNV	ENSG00000203326.12:ENST00000474037.6:exon3:c.A119T:p.N40I	19q13.42	C3L-04027	.	.	.	.	.	.	.	.	.	5.14	D	D	.	.	.	N	.	T	D	0.684	T	T	T	0.141	0.565	0.328	3.229	.	.	T	T	D	D	2.549	22.500	0.982	N	N	-0.529	1.121	-0.702	0.897	0.000	0.707	0.725	0.725	0.636	.	1.630	1.630	0.791	0.791	0.374	0.657	0.799	0.044	994	Krueppel-associated_box	.	.	.	ZNF525	336	0	537	35	0.0611888111888112	NA	TRUE
ENSG00000132622.11	.	BCM	GRCh38.p13	chr20	3749265	3749265	+	G	G	A	Missense_Mutation	SNP	ENST00000254963.7	exon9	c.G884A	p.R295H	exonic	ENSG00000132622.11	.	nonsynonymous SNV	ENSG00000132622.11:ENST00000254963.7:exon9:c.G884A:p.R295H	20p13	C3L-04027	2.677e-05	0	9.228e-05	0.0002	0	0	0	0	rs763936271	9.20	T	T	D	P	D	D	M	T	N	0.737	T	T	D	0.189	0.517	0.789	2.024	D	T	T	T	T	D	4.300	29.600	1.000	D	D	0.731	7.570	0.743	8.635	1.000	0.677	0.588	0.673	0.655	.	5.570	5.570	6.506	1.176	0.676	1.000	0.995	0.998	798	.	.	.	ID=COSV99422358;OCCURENCE=1(endometrium)	HSPA12B	322	0	664	45	0.0634696755994358	TRUE	NA
ENSG00000078814.17	.	BCM	GRCh38.p13	chr20	34986904	34986904	+	T	T	G	Missense_Mutation	SNP	ENST00000618182.6	exon12	c.T1046G	p.M349R	exonic	ENSG00000078814.17	.	nonsynonymous SNV	ENSG00000078814.17:ENST00000618182.6:exon12:c.T1046G:p.M349R	20q11.22	C3L-04027	.	.	.	.	.	.	.	.	.	4.16	D	T	.	.	N	D	.	T	N	0.480	T	T	D	0.086	.	0.396	0.265	T	.	T	T	T	D	3.359	24.300	0.970	N	N	-0.560	1.062	-0.415	1.346	0.397	0.403	0.514	0.578	0.646	.	3.660	3.660	1.501	1.138	0.665	0.864	1.000	0.974	626	Myosin_head,_motor_domain	.	.	.	MYH7B	174	0	337	25	0.069060773480663	TRUE	TRUE
ENSG00000101438.4	.	BCM	GRCh38.p13	chr20	38728362	38728362	+	C	C	T	Missense_Mutation	SNP	ENST00000217420.2	exon2	c.C1301T	p.T434M	exonic	ENSG00000101438.4	.	nonsynonymous SNV	ENSG00000101438.4:ENST00000217420.2:exon2:c.C1301T:p.T434M	20q11.23	C3L-04027	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.589	T	T	T	0.136	0.573	0.506	.	T	T	T	T	D	D	2.644	22.700	0.973	D	D	-0.012	2.467	0.138	2.896	1.000	0.598	0.627	0.378	0.639	.	4.610	4.610	3.930	1.022	0.596	1.000	1.000	0.994	926	Amino_acid_transporter,_transmembrane_domain	.	.	ID=COSV54147145;OCCURENCE=1(lung),1(upper_aerodigestive_tract),1(small_intestine)	SLC32A1	180	0	391	43	0.0990783410138249	TRUE	TRUE
ENSG00000149654.11	.	BCM	GRCh38.p13	chr20	46210323	46210323	+	C	C	T	Missense_Mutation	SNP	ENST00000537909.4	exon7	c.G1270A	p.A424T	exonic	ENSG00000149654.11	.	nonsynonymous SNV	ENSG00000149654.11:ENST00000537909.4:exon7:c.G1270A:p.A424T	20q13.12	C3L-04027	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	N	T	N	0.312	T	T	D	0.056	0.427	0.518	.	T	T	T	T	D	D	2.483	22.400	0.978	D	N	-0.327	1.549	-0.153	1.902	0.999	0.515	0.590	0.604	0.563	.	3.960	3.960	1.500	0.959	0.513	0.981	1.000	0.999	510	Cadherin-like	.	.	.	CDH22	143	0	289	20	0.0647249190938511	TRUE	NA
ENSG00000092758.18	.	BCM	GRCh38.p13	chr20	62829655	62829655	+	G	G	A	Missense_Mutation	SNP	ENST00000649368.1	exon21	c.G1081A	p.G361S	exonic	ENSG00000092758.18	.	nonsynonymous SNV	ENSG00000092758.18:ENST00000649368.1:exon21:c.G1081A:p.G361S	20q13.33	C3L-04027	6.835e-05	0	0	0.0005	0	4.067e-05	0	7.539e-05	rs745335790	19.20	D	D	D	D	D	D	H	D	D	0.934	D	D	D	0.969	0.818	0.923	0.420	D	T	D	D	D	D	3.595	25.000	0.998	D	D	0.829	9.368	0.672	7.256	1.000	0.696	0.547	0.723	0.568	.	4.720	4.720	5.437	1.079	0.672	1.000	0.096	0.062	867	.	.	.	ID=COSV104645910;OCCURENCE=1(large_intestine)	COL9A3	712	0	1227	93	0.0704545454545455	TRUE	NA
ENSG00000101161.8	.	BCM	GRCh38.p13	chr20	63983196	63983196	+	A	A	G	Missense_Mutation	SNP	ENST00000266079.5	exon2	c.A221G	p.N74S	exonic	ENSG00000101161.8	.	nonsynonymous SNV	ENSG00000101161.8:ENST00000266079.5:exon2:c.A221G:p.N74S	20q13.33	C3L-04027	.	.	.	.	.	.	.	.	.	16.20	D	T	D	D	D	D	M	T	D	0.588	D	D	D	0.506	0.478	0.915	2.649	D	D	T	T	D	D	3.130	23.700	0.998	D	D	0.534	5.307	0.535	5.491	1.000	0.707	0.672	0.702	0.714	.	5.220	5.220	9.249	1.312	0.691	1.000	0.987	0.657	.	PRP1_splicing_factor,_N-terminal	.	.	.	PRPF6	379	0	689	43	0.0587431693989071	TRUE	TRUE
ENSG00000158578.21	.	BCM	GRCh38.p13	chrX	55014829	55014829	+	C	C	A	Missense_Mutation	SNP	ENST00000650242.1	exon9	c.G1355T	p.R452L	exonic	ENSG00000158578.21	.	nonsynonymous SNV	ENSG00000158578.21:ENST00000650242.1:exon9:c.G1355T:p.R452L	Xp11.21	C3L-04027	.	.	.	.	.	.	.	.	.	15.19	T	T	D	D	D	D	L	D	D	0.864	D	D	D	0.847	0.739	0.985	1.468	T	D	D	D	D	D	3.325	24.200	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.640	5.640	7.844	0.947	0.599	1.000	1.000	0.997	104	Tetrapyrrole_biosynthesis,_5-aminolevulinic_acid_synthase;Aminotransferase,_class_I/classII	.	.	.	ALAS2	56	0	105	17	0.139344262295082	TRUE	TRUE
ENSG00000156925.12	.	BCM	GRCh38.p13	chrX	137567226	137567226	+	G	G	A	Missense_Mutation	SNP	ENST00000287538.10	exon1	c.G535A	p.V179M	exonic	ENSG00000156925.12	.	nonsynonymous SNV	ENSG00000156925.12:ENST00000287538.10:exon1:c.G535A:p.V179M	Xq26.3	C3L-04027	.	.	.	.	.	.	.	.	.	8.19	D	T	D	P	N	D	M	T	N	0.138	T	T	D	0.105	0.235	0.412	2.502	D	T	T	T	D	T	3.117	23.700	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	4.680	3.820	5.448	1.160	0.656	1.000	1.000	0.998	690	.	.	.	.	ZIC3	119	0	182	36	0.165137614678899	TRUE	NA
ENSG00000157933.10	.	BCM	GRCh38.p13	chr1	2303891	2303891	+	C	C	T	Silent	SNP	ENST00000378536.5	exon4	c.C1263T	p.L421L	exonic	ENSG00000157933.10	.	synonymous SNV	ENSG00000157933.10:ENST00000378536.5:exon4:c.C1263T:p.L421L	1p36.32	C3L-04027	0.0001	0	9.079e-05	0.0001	0	0.0001	0	0.0003	rs773045410	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66013372;OCCURENCE=1(stomach)	SKI	410	1	693	54	0.072289156626506	TRUE	TRUE
ENSG00000090432.7	.	BCM	GRCh38.p13	chr1	20501245	20501245	+	A	A	G	Silent	SNP	ENST00000264198.5	exon4	c.T504C	p.D168D	exonic	ENSG00000090432.7	.	synonymous SNV	ENSG00000090432.7:ENST00000264198.5:exon4:c.T504C:p.D168D	1p36.12	C3L-04027	.	.	.	.	.	.	.	.	rs964377314	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUL1	199	1	338	30	0.0815217391304348	TRUE	NA
ENSG00000121904.17	.	BCM	GRCh38.p13	chr1	33569492	33569492	+	C	C	G	Silent	SNP	ENST00000373388.6	exon53	c.G8019C	p.L2673L	exonic	ENSG00000121904.17	.	synonymous SNV	ENSG00000121904.17:ENST00000373388.6:exon53:c.G8019C:p.L2673L	1p35.1	C3L-04027	8.246e-06	0	0	0	0	0	0	6.062e-05	rs759916101	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53930253;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	CSMD2	208	0	360	31	0.0792838874680307	TRUE	TRUE
ENSG00000014914.21	.	BCM	GRCh38.p13	chr1	149934205	149934205	+	G	G	A	Silent	SNP	ENST00000439741.4	exon7	c.C669T	p.F223F	exonic	ENSG00000014914.21	.	synonymous SNV	ENSG00000014914.21:ENST00000439741.4:exon7:c.C669T:p.F223F	1q21.2	C3L-04027	8.237e-06	0	0	0	0	0	0	6.056e-05	rs781940783	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63807448;OCCURENCE=1(endometrium)	MTMR11	228	0	413	33	0.0739910313901345	TRUE	TRUE
ENSG00000127074.14	.	BCM	GRCh38.p13	chr1	192659376	192659376	+	G	G	A	Silent	SNP	ENST00000543215.5	exon6	c.G333A	p.R111R	exonic	ENSG00000127074.14	.	synonymous SNV	ENSG00000127074.14:ENST00000543215.5:exon6:c.G333A:p.R111R	1q31.2	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RGS13	154	0	223	24	0.097165991902834	TRUE	TRUE
ENSG00000136720.7	.	BCM	GRCh38.p13	chr2	128318420	128318420	+	G	G	A	Silent	SNP	ENST00000259241.7	exon1	c.C144T	p.R48R	exonic	ENSG00000136720.7	.	synonymous SNV	ENSG00000136720.7:ENST00000259241.7:exon1:c.C144T:p.R48R	2q14.3	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HS6ST1	195	0	310	39	0.111747851002865	NA	TRUE
ENSG00000115850.10	.	BCM	GRCh38.p13	chr2	135808474	135808474	+	G	G	A	Silent	SNP	ENST00000264162.7	exon8	c.C3873T	p.Y1291Y	exonic	ENSG00000115850.10	.	synonymous SNV	ENSG00000115850.10:ENST00000264162.7:exon8:c.C3873T:p.Y1291Y	2q21.3	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LCT	312	0	547	34	0.0585197934595525	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178712562	178712562	+	A	A	G	Silent	SNP	ENST00000591111.5	exon93	c.T26409C	p.D8803D	exonic	ENSG00000155657.27	.	synonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon93:c.T26409C:p.D8803D	2q31.2	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TTN	99	0	164	15	0.0837988826815642	TRUE	TRUE
ENSG00000153820.13	.	BCM	GRCh38.p13	chr2	228017743	228017743	+	A	A	C	Silent	SNP	ENST00000392056.8	exon7	c.T3111G	p.L1037L	exonic	ENSG00000153820.13	.	synonymous SNV	ENSG00000153820.13:ENST00000392056.8:exon7:c.T3111G:p.L1037L	2q36.3	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPHKAP	191	0	273	20	0.068259385665529	TRUE	TRUE
ENSG00000163359.16	.	BCM	GRCh38.p13	chr2	237369059	237369059	+	G	G	A	Silent	SNP	ENST00000295550.9	exon10	c.C4404T	p.I1468I	exonic	ENSG00000163359.16	.	synonymous SNV	ENSG00000163359.16:ENST00000295550.9:exon10:c.C4404T:p.I1468I	2q37.3	C3L-04027	3.298e-05	9.626e-05	8.651e-05	0.0001	0	1.499e-05	0	0	rs371075249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL6A3	411	1	701	58	0.0764163372859025	TRUE	NA
ENSG00000144668.12	.	BCM	GRCh38.p13	chr3	37519303	37519303	+	G	G	A	Silent	SNP	ENST00000264741.10	exon11	c.G1185A	p.A395A	exonic	ENSG00000144668.12	.	synonymous SNV	ENSG00000144668.12:ENST00000264741.10:exon11:c.G1185A:p.A395A	3p22.2	C3L-04027	3.353e-05	0	0	0	0	6.062e-05	0	0	rs753124626	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITGA9	501	1	846	47	0.0526315789473684	TRUE	NA
ENSG00000007402.11	.	BCM	GRCh38.p13	chr3	50376144	50376144	+	G	G	A	Silent	SNP	ENST00000479441.1	exon18	c.C1671T	p.Y557Y	exonic	ENSG00000007402.11	.	synonymous SNV	ENSG00000007402.11:ENST00000479441.1:exon18:c.C1671T:p.Y557Y	3p21.31	C3L-04027	8.305e-05	0	0	0.0001	0	0	0	0.0005	rs370651951	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA2D2	344	0	649	41	0.0594202898550725	TRUE	NA
ENSG00000112902.12	.	BCM	GRCh38.p13	chr5	9044538	9044538	+	G	G	A	Silent	SNP	ENST00000382496.10	exon22	c.C2940T	p.I980I	exonic	ENSG00000112902.12	.	synonymous SNV	ENSG00000112902.12:ENST00000382496.10:exon22:c.C2940T:p.I980I	5p15.31	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEMA5A	387	0	684	51	0.0693877551020408	TRUE	TRUE
ENSG00000131711.15	.	BCM	GRCh38.p13	chr5	72196811	72196811	+	G	G	A	Silent	SNP	ENST00000296755.12	exon5	c.G3456A	p.T1152T	exonic	ENSG00000131711.15	.	synonymous SNV	ENSG00000131711.15:ENST00000296755.12:exon5:c.G3456A:p.T1152T	5q13.2	C3L-04027	6.594e-05	0	8.646e-05	0	0	7.496e-05	0	0.0001	rs145061898	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57099043;OCCURENCE=2(large_intestine)	MAP1B	176	0	254	23	0.0830324909747292	TRUE	TRUE
ENSG00000113209.9	.	BCM	GRCh38.p13	chr5	141137123	141137123	+	G	G	A	Silent	SNP	ENST00000231134.8	exon1	c.G1689A	p.P563P	exonic	ENSG00000113209.9	.	synonymous SNV	ENSG00000113209.9:ENST00000231134.8:exon1:c.G1689A:p.P563P	5q31.3	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHB5	976	2	1468	86	0.0553410553410553	NA	TRUE
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	170067554	170067554	+	G	G	A	Silent	SNP	ENST00000520908.7	exon45	c.G4512A	p.T1504T	exonic	ENSG00000134516.18	.	synonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon45:c.G4512A:p.T1504T	5q35.1	C3L-04027	4.943e-05	0	0	0	0	7.494e-05	0	6.056e-05	rs376411478	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DOCK2	134	0	278	17	0.0576271186440678	TRUE	NA
ENSG00000146221.10	.	BCM	GRCh38.p13	chr6	44286183	44286183	+	G	G	A	Silent	SNP	ENST00000371505.5	exon3	c.C627T	p.G209G	exonic	ENSG00000146221.10	.	synonymous SNV	ENSG00000146221.10:ENST00000371505.5:exon3:c.C627T:p.G209G	6p21.1	C3L-04027	1.662e-05	0	0	0.0001	0	1.515e-05	0	0	rs202138207	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101025273;OCCURENCE=1(stomach)	TCTE1	154	0	266	19	0.0666666666666667	TRUE	NA
ENSG00000169583.13	.	BCM	GRCh38.p13	chr9	136994801	136994801	+	C	C	T	Silent	SNP	ENST00000494426.2	exon6	c.G591A	p.A197A	exonic	ENSG00000169583.13	.	synonymous SNV	ENSG00000169583.13:ENST00000494426.2:exon6:c.G591A:p.A197A	9q34.3	C3L-04027	0.0003	0.0003	0	0	0	0.0006	0	0	rs376417159	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLIC3	190	0	331	37	0.10054347826087	TRUE	NA
ENSG00000179292.5	.	BCM	GRCh38.p13	chr11	66295122	66295122	+	G	G	A	Silent	SNP	ENST00000327259.5	exon2	c.G876A	p.S292S	exonic	ENSG00000179292.5	.	synonymous SNV	ENSG00000179292.5:ENST00000327259.5:exon2:c.G876A:p.S292S	11q13.2	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM151A	152	0	243	32	0.116363636363636	TRUE	NA
ENSG00000151079.7	.	BCM	GRCh38.p13	chr12	4810569	4810569	+	C	C	T	Silent	SNP	ENST00000280684.3	exon1	c.C528T	p.I176I	exonic	ENSG00000151079.7	.	synonymous SNV	ENSG00000151079.7:ENST00000280684.3:exon1:c.C528T:p.I176I	12p13.32	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54973970;OCCURENCE=2(urinary_tract)	KCNA6	537	0	837	191	0.18579766536965	TRUE	TRUE
ENSG00000165899.11	.	BCM	GRCh38.p13	chr12	80336438	80336438	+	G	G	C	Silent	SNP	ENST00000547103.6	exon40	c.G4626C	p.L1542L	exonic	ENSG00000165899.11	.	synonymous SNV	ENSG00000165899.11:ENST00000547103.6:exon40:c.G4626C:p.L1542L	12q21.31	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OTOGL	100	0	157	10	0.0598802395209581	TRUE	TRUE
ENSG00000174015.10	.	BCM	GRCh38.p13	chr13	45714033	45714033	+	G	G	A	Silent	SNP	ENST00000310521.6	exon3	c.G1008A	p.G336G	exonic	ENSG00000174015.10	.	synonymous SNV	ENSG00000174015.10:ENST00000310521.6:exon3:c.G1008A:p.G336G	13q14.13	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CBY2	59	0	81	11	0.119565217391304	TRUE	NA
ENSG00000140937.14	.	BCM	GRCh38.p13	chr16	64982107	64982107	+	A	A	T	Silent	SNP	ENST00000268603.9	exon8	c.T1194A	p.A398A	exonic	ENSG00000140937.14	.	synonymous SNV	ENSG00000140937.14:ENST00000268603.9:exon8:c.T1194A:p.A398A	16q21	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDH11	136	0	237	15	0.0595238095238095	TRUE	TRUE
ENSG00000176678.6	.	BCM	GRCh38.p13	chr16	86579425	86579425	+	G	G	A	Silent	SNP	ENST00000320241.5	exon1	c.G702A	p.A234A	exonic	ENSG00000176678.6	.	synonymous SNV	ENSG00000176678.6:ENST00000320241.5:exon1:c.G702A:p.A234A	16q24.1	C3L-04027	.	.	.	.	.	.	.	.	rs766649546	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FOXL1	189	0	251	29	0.103571428571429	TRUE	NA
ENSG00000171456.20	.	BCM	GRCh38.p13	chr20	32436894	32436894	+	A	A	G	Silent	SNP	ENST00000375687.10	exon13	c.A4182G	p.E1394E	exonic	ENSG00000171456.20	.	synonymous SNV	ENSG00000171456.20:ENST00000375687.10:exon13:c.A4182G:p.E1394E	20q11.21	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ASXL1	306	0	466	37	0.073558648111332	TRUE	TRUE
ENSG00000159086.15	.	BCM	GRCh38.p13	chr21	32762238	32762238	+	A	A	C	Silent	SNP	ENST00000331923.9	exon4	c.T729G	p.P243P	exonic	ENSG00000159086.15	.	synonymous SNV	ENSG00000159086.15:ENST00000331923.9:exon4:c.T729G:p.P243P	21q22.11	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PAXBP1	347	1	635	35	0.0522388059701493	TRUE	NA
ENSG00000100346.18	.	BCM	GRCh38.p13	chr22	39686000	39686000	+	C	C	T	Silent	SNP	ENST00000402142.4	exon37	c.C6267T	p.S2089S	exonic	ENSG00000100346.18	.	synonymous SNV	ENSG00000100346.18:ENST00000402142.4:exon37:c.C6267T:p.S2089S	22q13.1	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA1I	22	0	25	5	0.166666666666667	TRUE	NA
ENSG00000073169.14	.	BCM	GRCh38.p13	chr22	50206396	50206396	+	C	C	G	Unknown	SNP	NA	NA	NA	NA	exonic	ENSG00000073169.14	.	unknown	UNKNOWN	22q13.33	C3L-04027	.	.	.	.	.	.	.	.	.	12.19	T	D	D	D	D	D	M	T	D	0.869	T	T	.	0.463	0.851	0.637	0.487	T	T	D	T	D	D	3.186	23.800	0.996	D	D	0.649	6.464	0.540	5.549	1.000	0.722	0.702	0.269	0.735	.	5.210	4.190	7.593	1.026	0.599	1.000	0.863	0.172	684	.	.	.	.	SELENOO	392	0	747	50	0.0627352572145546	TRUE	TRUE
ENSG00000134215.16	.	BCM	GRCh38.p13	chr1	107669400	107669400	+	T	T	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000134215.16	.	.	.	1p13.3	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VAV3	259	0	455	31	0.0637860082304527	TRUE	TRUE
ENSG00000160886.13	.	BCM	GRCh38.p13	chr8	142700454	142700454	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000160886.13	ENST00000292430.10:c.-74G>A	.	.	8q24.3	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LY6K	121	0	192	11	0.0541871921182266	TRUE	NA
ENSG00000153487.13	.	BCM	GRCh38.p13	chr13	110715595	110715595	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000153487.13	.	.	.	13q34	C3L-04027	9.144e-05	0	0.0003	0	0	0	0	0.0005	rs554816174	4.16	D	T	.	.	.	D	.	T	N	0.236	T	T	D	0.203	0.385	0.825	0.070	T	T	T	T	T	T	3.181	23.800	0.683	D	N	0.289	3.725	0.293	3.676	1.000	0.025	0.374	0.289	0.250	.	4.120	4.120	1.828	0.129	0.606	1.000	0.939	0.946	982	.	.	.	.	ING1	162	0	299	29	0.0884146341463415	TRUE	NA
ENSG00000207731.1	.	BCM	GRCh38.p13	chrX	147230805	147230805	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000207731.1	.	.	.	Xq27.3	C3L-04027	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR506	94	0	163	16	0.0893854748603352	TRUE	NA
ENSG00000117713.20	.	BCM	GRCh38.p13	chr1	26697510	26697510	+	-	NA	G	Frame_Shift_Ins	NA	ENST00000324856.13	exon1	c.1108dupG	p.Q372Afs*28	exonic	ENSG00000117713.20	.	frameshift insertion	ENSG00000117713.20:ENST00000324856.13:exon1:c.1108dupG:p.Q372Afs*28	1p36.11	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARID1A	NA	NA	NA	NA	NA	NA	NA
ENSG00000117010.17	.	BCM	GRCh38.p13	chr1	40546617	40546617	+	T	T	-	Nonsense_Mutation	SNP	ENST00000372699.8	exon5	c.294delT	p.L100*	exonic	ENSG00000117010.17	.	stopgain	ENSG00000117010.17:ENST00000372699.8:exon5:c.294delT:p.L100*	1p34.2	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF684	67	0	72	17	0.191011235955056	TRUE	TRUE
ENSG00000063660.9	.	BCM	GRCh38.p13	chr2	240462517	240462517	+	G	G	A	Missense_Mutation	SNP	ENST00000264039.7	exon3	c.G652A	p.V218M	exonic	ENSG00000063660.9	.	nonsynonymous SNV	ENSG00000063660.9:ENST00000264039.7:exon3:c.G652A:p.V218M	2q37.3	C3N-02585	2.03e-05	0	9.346e-05	0	0	1.82e-05	0	0	rs368146643	10.20	D	D	D	D	N	D	M	T	N	0.307	T	T	D	0.247	0.757	0.884	0.530	D	T	T	T	D	D	3.377	24.300	0.998	N	N	0.467	4.788	0.325	3.867	0.230	0.696	0.588	0.723	0.563	.	2.970	2.970	1.133	1.058	0.614	0.141	0.070	0.404	994	.	.	.	.	GPC1	99	0	94	17	0.153153153153153	TRUE	NA
ENSG00000168026.18	.	BCM	GRCh38.p13	chr3	39136360	39136360	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000431162.6	exon23	c.2970dupT	p.L992Ffs*5	exonic	ENSG00000168026.18	.	frameshift insertion	ENSG00000168026.18:ENST00000431162.6:exon23:c.2970dupT:p.L992Ffs*5	3p22.2	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TTC21A	NA	NA	NA	NA	NA	NA	NA
ENSG00000057019.16	.	BCM	GRCh38.p13	chr3	98811274	98811274	+	T	T	C	Missense_Mutation	SNP	ENST00000326840.11	exon12	c.A1496G	p.N499S	exonic	ENSG00000057019.16	.	nonsynonymous SNV	ENSG00000057019.16:ENST00000326840.11:exon12:c.A1496G:p.N499S	3q12.1	C3N-02585	.	.	.	.	.	.	.	.	rs377415899	2.20	T	T	B	B	N	N	L	D	N	0.143	T	T	D	0.104	.	0.829	0.078	T	T	T	T	T	T	1.521	15.870	0.976	N	N	-0.606	0.977	-0.506	1.193	1.000	0.732	0.588	0.744	0.734	.	5.580	3.080	0.449	-0.143	-0.112	0.006	0.419	0.821	809	.	.	.	.	DCBLD2	146	0	168	20	0.106382978723404	TRUE	NA
ENSG00000240682.10	.	BCM	GRCh38.p13	chr3	129156916	129156916	+	C	C	A	Missense_Mutation	SNP	ENST00000393295.8	exon4	c.G83T	p.R28L	exonic	ENSG00000240682.10;ENSG00000261796.1	.	nonsynonymous SNV	ENSG00000240682.10:ENST00000393295.8:exon4:c.G83T:p.R28L,ENSG00000261796.1:ENST00000418265.1:exon4:c.G83T:p.R28L	3q21.3	C3N-02585	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.597	T	T	D	0.254	0.635	0.043	2.003	T	T	T	T	D	D	4.407	31	0.998	D	D	0.705	7.184	0.665	7.144	0.983	0.707	0.725	0.725	0.714	.	4.860	4.860	5.692	0.980	0.549	1.000	0.998	0.976	391	.	.	.	.	ISY1	267	0	324	57	0.149606299212598	TRUE	TRUE
ENSG00000113083.14	.	BCM	GRCh38.p13	chr5	122074038	122074038	+	C	C	T	Missense_Mutation	SNP	ENST00000231004.5	exon4	c.G1010A	p.R337Q	exonic	ENSG00000113083.14	.	nonsynonymous SNV	ENSG00000113083.14:ENST00000231004.5:exon4:c.G1010A:p.R337Q	5q23.1	C3N-02585	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.752	T	T	T	0.421	0.779	0.701	1.241	T	T	D	T	D	D	4.402	31	1.000	D	D	0.867	10.227	0.854	11.922	1.000	0.660	0.588	0.659	0.651	.	5.980	5.980	7.568	1.026	0.599	1.000	0.999	0.997	692	.	.	.	ID=COSV50239356;OCCURENCE=1(cervix),1(large_intestine),1(urinary_tract),1(skin)	LOX	113	0	148	16	0.0975609756097561	TRUE	TRUE
ENSG00000204961.7	.	BCM	GRCh38.p13	chr5	140848545	140848545	+	C	C	T	Missense_Mutation	SNP	ENST00000532602.2	exon1	c.C50T	p.S17L	exonic	ENSG00000204961.7	.	nonsynonymous SNV	ENSG00000204961.7:ENST00000532602.2:exon1:c.C50T:p.S17L	5q31.3	C3N-02585	1.698e-05	0	0	0	0	0	0	0.0001	rs781970599	0.18	T	T	B	B	.	N	N	T	N	0.132	T	T	T	0.053	0.407	0.399	.	.	T	T	T	T	T	0.121	2.289	0.706	N	N	-1.329	0.149	-1.315	0.199	0.000	0.581	0.574	0.576	0.584	.	3.730	-0.077	-0.596	0.910	0.545	0.000	0.564	0.146	32	.	.	.	.	PCDHA9	393	0	313	77	0.197435897435897	TRUE	NA
ENSG00000113211.5	.	BCM	GRCh38.p13	chr5	141151848	141151848	+	G	G	A	Missense_Mutation	SNP	ENST00000231136.3	exon1	c.G1591A	p.A531T	exonic	ENSG00000113211.5	.	nonsynonymous SNV	ENSG00000113211.5:ENST00000231136.3:exon1:c.G1591A:p.A531T	5q31.3	C3N-02585	.	.	.	.	.	.	.	.	.	12.16	D	D	.	.	.	D	.	T	D	0.771	D	D	D	0.553	0.834	0.912	.	T	T	D	D	D	T	3.612	25.100	0.999	D	D	1.008	14.165	0.862	12.206	0.760	0.487	0.574	0.409	0.542	.	4.190	4.190	7.912	0.171	0.477	1.000	0.001	0.558	645	Cadherin-like	.	.	ID=COSV50718471;OCCURENCE=2(large_intestine)	PCDHB6	1391	1	1196	270	0.184174624829468	NA	TRUE
ENSG00000213316.10	.	BCM	GRCh38.p13	chr5	179795961	179795961	+	C	C	A	Missense_Mutation	SNP	ENST00000292596.15	exon4	c.C250A	p.L84M	exonic	ENSG00000213316.10	.	nonsynonymous SNV	ENSG00000213316.10:ENST00000292596.15:exon4:c.C250A:p.L84M	5q35.3	C3N-02585	.	.	.	.	.	.	.	.	.	8.19	D	D	D	P	U	D	M	T	N	0.391	T	T	D	0.343	0.700	0.453	1.091	D	T	T	T	D	.	2.596	22.600	0.974	N	N	0.019	2.581	-0.163	1.877	1.000	0.652	0.219	0.641	0.555	.	3.860	1.970	-0.090	0.064	0.442	0.001	0.989	0.993	900	.	.	.	.	LTC4S	532	0	552	136	0.197674418604651	TRUE	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152331133	152331133	+	G	G	A	Missense_Mutation	SNP	ENST00000367255.10	exon78	c.C13552T	p.R4518C	exonic	ENSG00000131018.24	.	nonsynonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon78:c.C13552T:p.R4518C	6q25.2	C3N-02585	8.237e-06	9.617e-05	0	0	0	0	0	0	rs569216024	14.20	D	D	D	D	D	D	M	T	D	0.770	T	T	D	0.244	0.500	0.541	0.707	T	D	T	T	D	D	3.323	24.200	0.996	D	D	0.630	6.248	0.586	6.053	0.998	0.554	0.574	0.574	0.568	.	6.030	6.030	3.349	1.176	0.676	1.000	0.887	0.554	847	.	.	.	ID=COSV54916166;OCCURENCE=1(pancreas),1(skin)	SYNE1	486	1	397	91	0.186475409836066	TRUE	TRUE
ENSG00000146530.14	.	BCM	GRCh38.p13	chr7	12377804	12377804	+	G	G	C	Missense_Mutation	SNP	ENST00000275358.8	exon7	c.C996G	p.I332M	exonic	ENSG00000146530.14	.	nonsynonymous SNV	ENSG00000146530.14:ENST00000275358.8:exon7:c.C996G:p.I332M	7p21.3	C3N-02585	.	.	.	.	.	.	.	.	.	9.19	D	D	D	P	.	N	M	D	N	0.303	T	D	D	0.331	0.202	0.246	.	T	T	T	T	D	T	2.574	22.600	0.996	D	N	0.078	2.802	-0.002	2.351	0.989	0.651	0.588	0.651	0.586	.	4.680	-1.010	0.902	-0.246	0.618	1.000	0.998	0.998	838	.	.	.	.	VWDE	72	0	88	24	0.214285714285714	TRUE	TRUE
ENSG00000177409.12	.	BCM	GRCh38.p13	chr7	93132497	93132497	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000318238.9	exon5	c.3474dupA	p.A1159Sfs*13	exonic	ENSG00000177409.12	.	frameshift insertion	ENSG00000177409.12:ENST00000318238.9:exon5:c.3474dupA:p.A1159Sfs*13	7q21.2	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SAMD9L	NA	NA	NA	NA	NA	NA	NA
ENSG00000211734.3	.	BCM	GRCh38.p13	chr7	142321100	142321114	+	TGCTGCTTTGTCTCC	TGCTGCTTTGTCTCC	-	In_Frame_Del	DEL	ENST00000390381.3	exon2	c.26_40del	p.L10_L14del	exonic	ENSG00000211734.3	.	nonframeshift deletion	ENSG00000211734.3:ENST00000390381.3:exon2:c.26_40del:p.L10_L14del	7q34	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRBV5-1	287	0	334	28	0.0773480662983425	TRUE	TRUE
ENSG00000085788.14	.	BCM	GRCh38.p13	chr8	38245755	38245755	+	A	A	G	Missense_Mutation	SNP	ENST00000397166.7	exon8	c.A862G	p.I288V	exonic	ENSG00000085788.14	.	nonsynonymous SNV	ENSG00000085788.14:ENST00000397166.7:exon8:c.A862G:p.I288V	8p11.23	C3N-02585	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	D	D	L	T	N	0.692	T	T	T	0.201	.	0.370	0.225	D	T	T	T	D	D	2.915	23.200	0.995	D	D	0.388	4.270	0.503	5.185	1.000	0.707	0.725	0.725	0.714	.	5.550	5.550	9.236	1.288	0.674	1.000	1.000	0.999	162	.	.	.	.	DDHD2	266	0	277	80	0.224089635854342	TRUE	NA
ENSG00000023287.13	.	BCM	GRCh38.p13	chr8	52656681	52656681	+	C	C	A	Missense_Mutation	SNP	ENST00000025008.10	exon15	c.G3148T	p.V1050F	exonic	ENSG00000023287.13	.	nonsynonymous SNV	ENSG00000023287.13:ENST00000025008.10:exon15:c.G3148T:p.V1050F	8q11.23	C3N-02585	.	.	.	.	.	.	.	.	.	5.20	D	T	P	B	N	D	M	T	N	0.130	T	T	T	0.111	0.134	0.251	0.386	T	T	T	T	D	T	2.102	20.100	0.988	D	N	0.002	2.520	0.097	2.724	0.623	0.732	0.725	0.710	0.728	.	5.400	4.480	0.540	1.026	0.599	0.738	0.874	0.923	867	.	.	.	.	RB1CC1	191	0	221	40	0.153256704980843	TRUE	TRUE
ENSG00000180921.7	.	BCM	GRCh38.p13	chr8	143726522	143726522	+	C	C	T	Missense_Mutation	SNP	ENST00000388913.4	exon5	c.G2939A	p.R980H	exonic	ENSG00000180921.7	.	nonsynonymous SNV	ENSG00000180921.7:ENST00000388913.4:exon5:c.G2939A:p.R980H	8q24.3	C3N-02585	.	.	.	.	.	.	.	.	.	3.19	T	T	D	P	N	N	L	T	N	0.129	T	T	D	0.052	0.201	0.068	0.414	T	T	T	T	D	.	2.511	22.400	0.995	N	N	0.131	3.012	0.094	2.709	1.000	0.650	0.551	0.607	0.563	.	5.110	3.270	0.521	0.074	0.594	0.045	0.081	0.168	889	.	.	.	.	FAM83H	797	0	806	177	0.180061037639878	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971029	21971029	+	C	C	T	Nonsense_Mutation	SNP	ENST00000304494.9	exon2	c.G330A	p.W110X	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon2:c.G330A:p.W110X	9p21.3	C3N-02585	.	.	.	.	.	.	.	.	rs121913389	9.15	D	D	.	.	N	D	.	D	D	0.436	T	T	.	0.455	.	0.972	.	.	T	D	D	D	T	7.707	39	0.995	N	D	0.352	4.061	0.344	3.981	1.000	0.610	0.383	0.607	0.639	.	5.930	5.930	0.403	1.026	0.599	0.062	0.998	0.991	900	.	.	.	ID=COSV58682827;OCCURENCE=3(penis),3(oesophagus),3(central_nervous_system),1(biliary_tract),2(vulva),3(haematopoietic_and_lymphoid_tissue),1(urinary_tract),1(soft_tissue),5(pancreas),16(skin),4(lung),31(upper_aerodigestive_tract),2(endometrium)	CDKN2A	1158	0	862	263	0.233777777777778	NA	TRUE
ENSG00000173258.13	.	BCM	GRCh38.p13	chr9	111542241	111542241	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000309235.6	exon6	c.1307dupA	p.T438Nfs*3	exonic	ENSG00000173258.13	.	frameshift insertion	ENSG00000173258.13:ENST00000309235.6:exon6:c.1307dupA:p.T438Nfs*3	9q31.3	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF483	NA	NA	NA	NA	NA	NA	NA
ENSG00000151150.22	.	BCM	GRCh38.p13	chr10	60071372	60071372	+	T	T	C	Missense_Mutation	SNP	ENST00000280772.7	exon37	c.A9509G	p.E3170G	exonic	ENSG00000151150.22	.	nonsynonymous SNV	ENSG00000151150.22:ENST00000280772.7:exon37:c.A9509G:p.E3170G	10q21.2	C3N-02585	.	.	.	.	.	.	.	.	.	16.19	D	.	D	D	D	D	M	T	D	0.799	T	T	D	0.477	0.150	0.574	0.653	D	D	D	D	D	D	4.119	27.900	0.999	D	D	0.687	6.937	0.692	7.602	1.000	0.487	0.492	0.547	0.564	.	5.480	5.480	8.017	1.138	0.665	1.000	1.000	0.998	720	.	.	.	.	ANK3	380	0	445	88	0.165103189493433	TRUE	TRUE
ENSG00000165832.6	.	BCM	GRCh38.p13	chr10	114970389	114970389	+	T	T	C	Missense_Mutation	SNP	ENST00000298746.5	exon5	c.T545C	p.I182T	exonic	ENSG00000165832.6	.	nonsynonymous SNV	ENSG00000165832.6:ENST00000298746.5:exon5:c.T545C:p.I182T	10q25.3	C3N-02585	3.302e-05	0	0	0	0	6.003e-05	0	0	rs572364497	10.20	D	D	P	P	N	D	M	T	D	0.659	T	T	T	0.338	0.891	0.809	0.598	T	T	T	D	D	D	3.760	25.700	0.998	D	D	0.518	5.178	0.570	5.871	1.000	0.732	0.744	0.710	0.634	.	5.660	5.660	6.171	1.138	0.665	1.000	0.998	0.991	894	Pseudouridine_synthase_II,_N-terminal	.	.	.	TRUB1	182	0	176	46	0.207207207207207	TRUE	NA
ENSG00000117983.17	.	BCM	GRCh38.p13	chr11	1227677	1227677	+	G	G	A	Missense_Mutation	SNP	ENST00000529681.5	exon7	c.G670A	p.A224T	exonic	ENSG00000117983.17	.	nonsynonymous SNV	ENSG00000117983.17:ENST00000529681.5:exon7:c.G670A:p.A224T	11p15.5	C3N-02585	4.948e-05	0	0	0	0	0	0	0.0001	rs745336157	0.18	T	.	B	B	.	N	N	T	N	0.073	T	T	T	0.026	.	0.043	.	T	T	T	T	T	T	-0.687	0.047	0.689	N	N	-1.711	0.035	-1.727	0.046	0.001	0.403	0.547	0.578	0.563	.	3.490	-2.000	-0.454	-2.694	-1.579	0.000	0.000	0.002	964	von_Willebrand_factor,_type_D_domain	.	.	.	MUC5B	150	0	233	20	0.0790513833992095	TRUE	NA
ENSG00000197674.7	.	BCM	GRCh38.p13	chr11	4690925	4690925	+	G	G	T	Missense_Mutation	SNP	ENST00000641159.1	exon2	c.C772A	p.L258M	exonic	ENSG00000197674.7	.	nonsynonymous SNV	ENSG00000197674.7:ENST00000641159.1:exon2:c.C772A:p.L258M	11p15.4	C3N-02585	.	.	.	.	.	.	.	.	.	1.6	.	.	.	.	N	D	.	.	.	.	T	T	.	0.066	.	.	.	.	.	.	.	.	T	2.320	21.700	0.994	N	.	-0.218	1.826	-0.284	1.597	0.000	0.487	0.574	0.574	0.564	0.248	4.670	1.740	0.029	-0.101	0.676	0.001	0.965	0.702	852	.	.	.	.	OR51C1P	87	0	130	23	0.150326797385621	TRUE	NA
ENSG00000162231.14	.	BCM	GRCh38.p13	chr11	62796461	62796461	+	G	G	A	Nonsense_Mutation	SNP	ENST00000294172.7	exon14	c.C1285T	p.R429X	exonic	ENSG00000162231.14	.	stopgain	ENSG00000162231.14:ENST00000294172.7:exon14:c.C1285T:p.R429X	11q12.3	C3N-02585	.	.	.	.	.	.	.	.	.	6.6	.	.	.	.	D	D	.	.	.	0.853	.	.	.	.	.	.	.	.	.	D	D	.	.	7.897	40	0.997	D	D	0.738	7.690	0.546	5.607	1.000	0.672	0.702	0.702	0.711	.	5.130	4.210	5.523	1.176	0.676	1.000	0.984	0.756	779	Nuclear_transport_factor_2,_eukaryote;Nuclear_transport_factor_2	.	.	ID=COSV53677747;OCCURENCE=1(skin)	NXF1	318	0	311	62	0.166219839142091	TRUE	NA
ENSG00000072518.20	.	BCM	GRCh38.p13	chr11	63904109	63904109	+	-	NA	C	Frame_Shift_Ins	NA	ENST00000402010.6	exon15	c.1639dupC	p.T549Hfs*4	exonic	ENSG00000072518.20	.	frameshift insertion	ENSG00000072518.20:ENST00000402010.6:exon15:c.1639dupC:p.T549Hfs*4	11q13.1	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MARK2	NA	NA	NA	NA	NA	NA	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-02585	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	362	0	458	100	0.17921146953405	TRUE	TRUE
ENSG00000136011.15	.	BCM	GRCh38.p13	chr12	103638181	103638181	+	C	C	A	Missense_Mutation	SNP	ENST00000388887.7	exon8	c.C875A	p.S292Y	exonic	ENSG00000136011.15	.	nonsynonymous SNV	ENSG00000136011.15:ENST00000388887.7:exon8:c.C875A:p.S292Y	12q23.3	C3N-02585	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.874	T	T	T	0.339	0.485	0.674	0.447	T	D	D	D	D	T	3.245	24.000	0.993	D	D	0.486	4.926	0.371	4.161	1.000	0.447	0.547	0.547	0.530	.	5.470	5.470	5.967	1.026	0.599	0.960	0.148	0.246	863	.	.	.	.	STAB2	185	0	226	16	0.0661157024793388	TRUE	TRUE
ENSG00000111271.15	.	BCM	GRCh38.p13	chr12	111728095	111728096	+	CA	CA	-	Frame_Shift_Del	DEL	ENST00000313698.9	exon9	c.1195_1196del	p.H399Qfs*10	exonic	ENSG00000111271.15	.	frameshift deletion	ENSG00000111271.15:ENST00000313698.9:exon9:c.1195_1196del:p.H399Qfs*10	12q24.12	C3N-02585	1.656e-05	9.617e-05	0	0	0	0	0	6.214e-05	rs774510931	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACAD10	172	0	177	36	0.169014084507042	TRUE	NA
ENSG00000135094.11	.	BCM	GRCh38.p13	chr12	113398816	113398816	+	G	G	A	Missense_Mutation	SNP	ENST00000257549.9	exon4	c.C224T	p.A75V	exonic	ENSG00000135094.11	.	nonsynonymous SNV	ENSG00000135094.11:ENST00000257549.9:exon4:c.C224T:p.A75V	12q24.13	C3N-02585	6.334e-05	0.0001	0.0001	0	0	7.071e-05	0	0	rs541907463	13.20	D	T	P	B	D	N	M	D	D	0.424	D	D	D	0.516	.	0.935	0.322	T	D	T	D	T	D	2.075	19.830	0.999	D	D	-0.027	2.416	-0.145	1.925	0.724	0.497	0.547	0.547	0.542	.	3.880	3.880	5.036	1.164	0.662	0.937	0.013	0.273	867	Pyridoxal-phosphate_dependent_enzyme	.	.	.	SDS	222	0	277	82	0.228412256267409	TRUE	NA
ENSG00000136114.17	.	BCM	GRCh38.p13	chr13	52377721	52377721	+	C	C	G	Missense_Mutation	SNP	ENST00000258613.5	exon5	c.G2249C	p.G750A	exonic	ENSG00000136114.17	.	nonsynonymous SNV	ENSG00000136114.17:ENST00000258613.5:exon5:c.G2249C:p.G750A	13q14.3	C3N-02585	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	D	0.086	T	T	T	0.024	0.141	0.085	0.289	T	T	T	T	T	T	0.867	10.090	0.897	N	N	-0.622	0.949	-0.577	1.081	0.211	0.707	0.588	0.547	0.714	.	5.280	3.530	1.660	1.026	0.597	0.116	0.198	0.880	783	.	.	.	.	THSD1	132	0	139	34	0.196531791907514	TRUE	TRUE
ENSG00000128731.18	.	BCM	GRCh38.p13	chr15	28196323	28196323	+	C	C	A	Nonsense_Mutation	SNP	ENST00000261609.13	exon52	c.G8152T	p.G2718X	exonic	ENSG00000128731.18	.	stopgain	ENSG00000128731.18:ENST00000261609.13:exon52:c.G8152T:p.G2718X	15q13.1	C3N-02585	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.940	.	.	.	.	.	.	.	.	.	D	D	.	.	9.181	48	0.989	D	N	1.160	20.690	1.015	19.774	1.000	0.707	0.725	0.725	0.714	.	5.300	5.300	7.905	1.018	0.599	1.000	1.000	0.998	878	Zinc_finger,_ZZ-type	.	.	.	HERC2	40	0	54	12	0.181818181818182	NA	TRUE
ENSG00000159248.5	.	BCM	GRCh38.p13	chr15	34753124	34753124	+	C	C	T	Missense_Mutation	SNP	ENST00000290374.5	exon2	c.G320A	p.R107H	exonic	ENSG00000159248.5	.	nonsynonymous SNV	ENSG00000159248.5:ENST00000290374.5:exon2:c.G320A:p.R107H	15q14	C3N-02585	.	.	.	.	.	.	.	.	.	16.20	T	D	D	P	D	D	L	D	N	0.311	D	D	D	0.754	0.394	0.917	2.204	D	D	D	D	D	D	3.394	24.400	0.999	D	D	0.558	5.521	0.605	6.283	1.000	0.447	0.563	0.507	0.632	.	4.900	4.900	7.852	1.026	0.599	1.000	0.983	0.953	912	Connexin,_N-terminal	.	.	.	GJD2	602	2	701	108	0.133498145859085	TRUE	NA
ENSG00000171345.13	.	BCM	GRCh38.p13	chr17	41523981	41523982	+	TC	TC	-	Frame_Shift_Del	DEL	ENST00000361566.7	exon6	c.964_965del	p.D322Hfs*24	exonic	ENSG00000171345.13	.	frameshift deletion	ENSG00000171345.13:ENST00000361566.7:exon6:c.964_965del:p.D322Hfs*24	17q21.2	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KRT19	262	0	265	62	0.18960244648318	TRUE	TRUE
ENSG00000158270.12	.	BCM	GRCh38.p13	chr18	346960	346960	+	G	G	A	Missense_Mutation	SNP	ENST00000400256.5	exon5	c.C662T	p.T221M	exonic	ENSG00000158270.12	.	nonsynonymous SNV	ENSG00000158270.12:ENST00000400256.5:exon5:c.C662T:p.T221M	18p11.32	C3N-02585	4.942e-05	0.0006	0	0	0	0	0	0	rs148602317	2.20	T	D	B	B	N	N	N	T	N	0.344	T	T	D	0.100	.	0.196	0.544	T	T	T	T	T	T	2.602	22.600	0.984	N	N	-0.744	0.740	-0.624	1.010	0.994	0.707	0.574	0.618	0.714	.	6.080	1.950	1.634	0.230	-0.106	0.401	0.750	0.782	822	.	.	.	.	COLEC12	199	0	254	62	0.19620253164557	TRUE	NA
ENSG00000105227.15	.	BCM	GRCh38.p13	chr19	40394382	40394382	+	C	C	T	Missense_Mutation	SNP	ENST00000324001.8	exon7	c.G3970A	p.E1324K	exonic	ENSG00000105227.15	.	nonsynonymous SNV	ENSG00000105227.15:ENST00000324001.8:exon7:c.G3970A:p.E1324K	19q13.2	C3N-02585	.	.	.	.	.	.	.	.	.	2.20	T	D	B	B	N	D	L	T	N	0.285	T	T	T	0.069	0.309	0.542	0.254	T	T	T	T	T	T	2.248	21.200	0.997	N	N	-0.193	1.895	-0.144	1.927	0.706	0.646	0.634	0.645	0.605	.	4.790	4.790	2.040	1.015	0.587	0.066	0.599	0.931	754	.	.	.	.	PRX	222	0	238	51	0.176470588235294	TRUE	NA
ENSG00000105618.14	.	BCM	GRCh38.p13	chr19	54118380	54118380	+	T	T	A	Missense_Mutation	SNP	ENST00000321030.9	exon2	c.T102A	p.D34E	exonic	ENSG00000105618.14	.	nonsynonymous SNV	ENSG00000105618.14:ENST00000321030.9:exon2:c.T102A:p.D34E	19q13.42	C3N-02585	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	N	D	N	0.141	T	T	D	0.264	0.220	0.642	0.777	T	T	T	T	T	T	1.027	11.960	0.966	D	N	-0.548	1.084	-0.402	1.368	0.650	0.707	0.725	0.702	0.714	.	4.770	1.550	0.018	0.190	-0.134	0.964	0.998	0.994	994	.	.	.	.	PRPF31	428	0	488	110	0.183946488294314	TRUE	TRUE
ENSG00000089057.15	.	BCM	GRCh38.p13	chr20	4869951	4869951	+	G	G	A	Missense_Mutation	SNP	ENST00000338244.6	exon12	c.C1205T	p.A402V	exonic	ENSG00000089057.15	.	nonsynonymous SNV	ENSG00000089057.15:ENST00000338244.6:exon12:c.C1205T:p.A402V	20p13	C3N-02585	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.960	T	T	D	0.660	0.739	0.305	1.929	D	T	D	D	D	D	3.730	25.500	0.999	D	D	0.822	9.223	0.688	7.532	1.000	0.722	0.725	0.725	0.735	.	5.490	5.490	10.003	1.176	0.676	1.000	0.487	0.457	886	.	.	.	.	SLC23A2	201	0	215	52	0.194756554307116	TRUE	TRUE
ENSG00000133454.16	.	BCM	GRCh38.p13	chr22	25798079	25798079	+	G	G	A	Missense_Mutation	SNP	ENST00000335473.12	exon12	c.G2503A	p.A835T	exonic	ENSG00000133454.16	.	nonsynonymous SNV	ENSG00000133454.16:ENST00000335473.12:exon12:c.G2503A:p.A835T	22q12.1	C3N-02585	4.314e-05	0	8.873e-05	0	0	6.246e-05	0	0	rs755534991	17.20	T	D	D	D	D	D	M	D	D	0.675	D	D	D	0.551	0.614	0.888	0.345	T	T	D	D	D	D	3.875	26.200	0.998	D	D	0.248	3.523	0.129	2.856	1.000	0.487	0.563	0.574	0.564	.	5.430	4.420	9.504	1.083	0.676	1.000	0.002	0.031	982	Class_XVIII_myosin,_motor_domain;Myosin_head,_motor_domain	.	.	.	MYO18B	152	0	157	12	0.0710059171597633	TRUE	NA
ENSG00000169933.15	.	BCM	GRCh38.p13	chrX	12716434	12716434	+	G	G	A	Missense_Mutation	SNP	ENST00000380682.5	exon15	c.G1975A	p.A659T	exonic	ENSG00000169933.15	.	nonsynonymous SNV	ENSG00000169933.15:ENST00000380682.5:exon15:c.G1975A:p.A659T	Xp22.2	C3N-02585	5.702e-05	0	0.0004	0.0002	0	0	0	0	rs760858730	1.19	T	T	B	B	N	N	L	T	N	0.073	T	T	T	0.062	0.302	0.204	0.123	T	T	T	T	T	T	0.526	6.771	0.910	D	.	.	.	.	.	0.055	.	.	.	.	.	5.860	5.000	1.968	-0.145	-0.750	0.968	0.439	0.364	728	.	.	.	ID=COSV101043886;OCCURENCE=1(upper_aerodigestive_tract)	FRMPD4	158	0	151	83	0.354700854700855	TRUE	NA
ENSG00000165288.11	.	BCM	GRCh38.p13	chrX	80709531	80709531	+	C	C	T	Missense_Mutation	SNP	ENST00000373275.5	exon21	c.G2372A	p.R791H	exonic	ENSG00000165288.11	.	nonsynonymous SNV	ENSG00000165288.11:ENST00000373275.5:exon21:c.G2372A:p.R791H	Xq21.1	C3N-02585	.	.	.	.	.	.	.	.	.	8.19	D	D	P	B	N	D	M	T	D	0.240	T	T	T	0.122	0.312	0.663	1.148	T	D	T	T	D	T	2.310	21.600	0.997	D	.	.	.	.	.	0.595	.	.	.	.	.	5.470	4.610	4.112	0.120	-0.182	1.000	0.981	0.894	681	.	.	.	ID=COSV64743418;OCCURENCE=1(large_intestine),1(endometrium)	BRWD3	129	0	121	60	0.331491712707182	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7676274	7676274	+	T	T	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon4:c.97-2A>T	.	.	17p13.1	C3N-02585	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.678	32	0.771	D	.	0.498	5.020	0.177	3.075	0.858	0.257	0.272	0.293	0.120	0.099	3.590	3.590	1.423	1.082	0.661	0.993	0.100	0.032	434	.	.	.	ID=COSV52678373;OCCURENCE=4(liver),3(large_intestine),1(ovary),1(kidney),1(soft_tissue),6(lung),1(upper_aerodigestive_tract)	TP53	378	0	343	117	0.254347826086956	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51049326	51049326	+	T	T	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141646.14;ENSG00000267699.2	ENST00000342988.8:exon4:c.454+2T>A;ENST00000590722.2:exon5:c.738+2T>A;ENST00000590722.2:exon5:UTR3	.	.	18q21.2	C3N-02585	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.085	35	0.994	D	.	1.097	17.365	0.963	16.731	1.000	0.164	0.106	0.128	0.243	0.981	5.920	5.920	5.441	1.138	0.609	1.000	1.000	0.999	683	.	.	.	ID=COSV61687223;OCCURENCE=1(pancreas)	SMAD4	275	1	250	56	0.183006535947712	TRUE	TRUE
ENSG00000189339.12	.	BCM	GRCh38.p13	chr1	1671580	1671580	+	C	C	A	Silent	SNP	ENST00000617444.5	exon6	c.G636T	p.L212L	exonic	ENSG00000189339.12	.	synonymous SNV	ENSG00000189339.12:ENST00000617444.5:exon6:c.G636T:p.L212L	1p36.33	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC35E2B	136	0	119	25	0.173611111111111	TRUE	TRUE
ENSG00000206557.6	.	BCM	GRCh38.p13	chr3	32818362	32818362	+	C	C	T	Silent	SNP	ENST00000383763.6	exon1	c.C282T	p.C94C	exonic	ENSG00000206557.6	.	synonymous SNV	ENSG00000206557.6:ENST00000383763.6:exon1:c.C282T:p.C94C	3p22.3	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIM71	551	1	576	139	0.194405594405594	TRUE	TRUE
ENSG00000159692.15	.	BCM	GRCh38.p13	chr4	1228209	1228209	+	G	G	A	Silent	SNP	ENST00000290921.10	exon3	c.C330T	p.A110A	exonic	ENSG00000159692.15	.	synonymous SNV	ENSG00000159692.15:ENST00000290921.10:exon3:c.C330T:p.A110A	4p16.3	C3N-02585	8.247e-06	0	0	0.0001	0	0	0	0	rs199545251	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTBP1	103	1	154	37	0.193717277486911	TRUE	NA
ENSG00000152969.20	.	BCM	GRCh38.p13	chr4	6105731	6105731	+	G	G	A	Silent	SNP	ENST00000282924.9	exon3	c.C366T	p.D122D	exonic	ENSG00000152969.20	.	synonymous SNV	ENSG00000152969.20:ENST00000282924.9:exon3:c.C366T:p.D122D	4p16.1	C3N-02585	2.246e-05	0	0	0	0	0	0	0.0001	rs199613129	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	JAKMIP1	387	0	434	96	0.181132075471698	TRUE	NA
ENSG00000231852.9	.	BCM	GRCh38.p13	chr6	32039415	32039415	+	C	C	T	Silent	SNP	ENST00000644719.2	exon4	c.C507T	p.T169T	exonic	ENSG00000231852.9	.	synonymous SNV	ENSG00000231852.9:ENST00000644719.2:exon4:c.C507T:p.T169T	6p21.33	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CYP21A2	1188	0	872	278	0.241739130434783	NA	TRUE
ENSG00000181472.5	.	BCM	GRCh38.p13	chr6	151373548	151373548	+	G	G	A	Silent	SNP	ENST00000325144.5	exon2	c.C90T	p.I30I	exonic	ENSG00000181472.5	.	synonymous SNV	ENSG00000181472.5:ENST00000325144.5:exon2:c.C90T:p.I30I	6q25.1	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZBTB2	375	0	326	24	0.0685714285714286	TRUE	TRUE
ENSG00000099139.14	.	BCM	GRCh38.p13	chr9	76354035	76354035	+	A	A	T	Silent	SNP	ENST00000545128.5	exon36	c.A4989T	p.G1663G	exonic	ENSG00000099139.14	.	synonymous SNV	ENSG00000099139.14:ENST00000545128.5:exon36:c.A4989T:p.G1663G	9q21.13	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCSK5	142	0	172	58	0.252173913043478	TRUE	TRUE
ENSG00000214655.10	.	BCM	GRCh38.p13	chr10	73789985	73789985	+	C	C	T	Silent	SNP	ENST00000605216.5	exon6	c.C768T	p.D256D	exonic	ENSG00000214655.10	.	synonymous SNV	ENSG00000214655.10:ENST00000605216.5:exon6:c.C768T:p.D256D	10q22.2	C3N-02585	1.832e-05	0	0	0.0001	0	0	0	6.874e-05	rs753132557	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101290168;OCCURENCE=1(endometrium)	ZSWIM8	284	0	355	68	0.160756501182033	TRUE	NA
ENSG00000176895.9	.	BCM	GRCh38.p13	chr11	4907750	4907750	+	C	C	T	Silent	SNP	ENST00000641490.1	exon2	c.C381T	p.H127H	exonic	ENSG00000176895.9	.	synonymous SNV	ENSG00000176895.9:ENST00000641490.1:exon2:c.C381T:p.H127H	11p15.4	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR51A7	238	0	260	68	0.207317073170732	TRUE	TRUE
ENSG00000173599.15	.	BCM	GRCh38.p13	chr11	66853378	66853378	+	G	G	A	Silent	SNP	ENST00000393960.7	exon13	c.C1374T	p.N458N	exonic	ENSG00000173599.15	.	synonymous SNV	ENSG00000173599.15:ENST00000393960.7:exon13:c.C1374T:p.N458N	11q13.2	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PC	461	0	484	120	0.198675496688742	TRUE	TRUE
ENSG00000111262.6	.	BCM	GRCh38.p13	chr12	4911948	4911948	+	C	C	T	Silent	SNP	ENST00000382545.5	exon2	c.C570T	p.P190P	exonic	ENSG00000111262.6	.	synonymous SNV	ENSG00000111262.6:ENST00000382545.5:exon2:c.C570T:p.P190P	12p13.32	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCNA1	222	0	274	73	0.210374639769452	TRUE	TRUE
ENSG00000173821.19	.	BCM	GRCh38.p13	chr17	80345511	80345511	+	G	G	A	Silent	SNP	ENST00000508628.6	exon30	c.G7323A	p.T2441T	exonic	ENSG00000173821.19	.	synonymous SNV	ENSG00000173821.19:ENST00000508628.6:exon30:c.G7323A:p.T2441T	17q25.3	C3N-02585	2.475e-05	0	0	0.0001	0	3e-05	0	0	rs774601132	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60398008;OCCURENCE=2(pancreas)	RNF213	97	0	120	12	0.0909090909090909	TRUE	TRUE
ENSG00000181143.15	.	BCM	GRCh38.p13	chr19	8894962	8894962	+	G	G	A	Silent	SNP	ENST00000397910.8	exon46	c.C39768T	p.Y13256Y	exonic	ENSG00000181143.15	.	synonymous SNV	ENSG00000181143.15:ENST00000397910.8:exon46:c.C39768T:p.Y13256Y	19p13.2	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC16	243	0	277	63	0.185294117647059	TRUE	TRUE
ENSG00000130167.13	.	BCM	GRCh38.p13	chr19	11298321	11298321	+	C	C	T	Silent	SNP	ENST00000316737.5	exon2	c.C249T	p.S83S	exonic	ENSG00000130167.13	.	synonymous SNV	ENSG00000130167.13:ENST00000316737.5:exon2:c.C249T:p.S83S	19p13.2	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TSPAN16	362	0	365	49	0.118357487922705	TRUE	TRUE
ENSG00000176988.9	.	BCM	GRCh38.p13	chrX	147981510	147981510	+	G	G	A	Silent	SNP	ENST00000370467.8	exon1	c.G108A	p.S36S	exonic	ENSG00000176988.9	.	synonymous SNV	ENSG00000176988.9:ENST00000370467.8:exon1:c.G108A:p.S36S	Xq27.3	C3N-02585	0.0001	0	0	0	0	0.0002	0	0	rs151160499	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65070991;OCCURENCE=1(large_intestine),1(skin)	FMR1NB	260	1	265	60	0.184615384615385	TRUE	TRUE
ENSG00000114948.13	.	BCM	GRCh38.p13	chr2	206605827	206605827	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000114948.13	.	.	.	2q33.3	C3N-02585	.	.	.	.	.	.	.	.	rs995523709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAM23	224	0	276	53	0.161094224924012	TRUE	NA
ENSG00000170791.18	.	BCM	GRCh38.p13	chr8	56212856	56212856	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000170791.18	.	.	.	8q12.1	C3N-02585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHCHD7	114	0	154	36	0.189473684210526	TRUE	TRUE
ENSG00000286708.1	.	BCM	GRCh38.p13	chr11	70907861	70907861	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000286708.1;ENSG00000172900.12	dist=11556;dist=474740	.	.	11q13.4	C3N-02585	8.29e-05	0	0	0	0	0	0	0.0001	rs781914901	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58344310;OCCURENCE=1(ovary)	AP003783.1	340	0	407	76	0.157349896480331	TRUE	NA
ENSG00000175707.9	.	BCM	GRCh38.p13	chr1	26951461	26951461	+	C	C	-	Frame_Shift_Del	DEL	ENST00000320567.6	exon2	c.920delG	p.R307Qfs*42	exonic	ENSG00000175707.9	.	frameshift deletion	ENSG00000175707.9:ENST00000320567.6:exon2:c.920delG:p.R307Qfs*42	1p36.11	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KDF1	141	0	170	49	0.223744292237443	TRUE	TRUE
ENSG00000134262.13	.	BCM	GRCh38.p13	chr1	113901796	113901796	+	C	C	A	Missense_Mutation	SNP	ENST00000369569.6	exon3	c.G428T	p.G143V	exonic	ENSG00000134262.13	.	nonsynonymous SNV	ENSG00000134262.13:ENST00000369569.6:exon3:c.G428T:p.G143V	1p13.2	C3N-03039	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.877	T	T	D	0.351	0.709	0.764	0.626	T	T	D	D	D	D	3.837	26.000	0.998	D	D	0.791	8.611	0.745	8.691	1.000	0.706	0.663	0.710	0.714	.	5.470	4.500	5.342	1.026	0.599	1.000	0.990	0.994	574	Clathrin/coatomer_adaptor,_adaptin-like,_N-terminal	.	.	.	AP4B1	354	1	561	166	0.228335625859697	TRUE	TRUE
ENSG00000047410.14	.	BCM	GRCh38.p13	chr1	186362953	186362953	+	T	T	C	Missense_Mutation	SNP	ENST00000367478.9	exon6	c.A580G	p.N194D	exonic	ENSG00000047410.14	.	nonsynonymous SNV	ENSG00000047410.14:ENST00000367478.9:exon6:c.A580G:p.N194D	1q31.1	C3N-03039	.	.	.	.	.	.	.	.	.	9.20	D	T	P	B	D	D	M	T	N	0.534	T	T	T	0.112	0.374	0.563	0.515	D	T	T	T	D	D	3.155	23.800	0.997	D	D	0.568	5.612	0.579	5.969	1.000	0.732	0.744	0.725	0.728	.	5.530	5.530	4.700	1.138	0.665	1.000	0.998	0.995	305	.	.	.	.	TPR	126	0	245	58	0.191419141914191	TRUE	TRUE
ENSG00000163793.13	.	BCM	GRCh38.p13	chr2	27276776	27276776	+	G	G	A	Missense_Mutation	SNP	ENST00000296097.8	exon3	c.G48A	p.M16I	exonic	ENSG00000163793.13	.	nonsynonymous SNV	ENSG00000163793.13:ENST00000296097.8:exon3:c.G48A:p.M16I	2p23.3	C3N-03039	2.473e-05	0	0.0003	0	0	0	0	0	rs200578672	1.20	D	T	B	B	N	N	N	T	N	0.118	T	T	T	0.015	.	0.067	0.078	T	T	T	T	T	T	-0.644	0.058	0.692	N	N	-1.403	0.115	-1.460	0.124	0.039	0.554	0.590	0.602	0.530	.	4.350	-4.320	-1.267	-2.780	-1.761	0.000	0.000	0.001	162	DnaJ_domain	.	.	.	DNAJC5G	228	0	339	93	0.215277777777778	TRUE	NA
ENSG00000135916.16	.	BCM	GRCh38.p13	chr2	230873465	230873465	+	G	G	A	Missense_Mutation	SNP	ENST00000326427.11	exon2	c.G169A	p.G57S	exonic	ENSG00000135916.16	.	nonsynonymous SNV	ENSG00000135916.16:ENST00000326427.11:exon2:c.G169A:p.G57S	2q37.1	C3N-03039	9.951e-05	9.713e-05	0	0.0001	0	1.507e-05	0	0.0006	rs201325357	2.20	T	T	P	B	N	D	N	T	N	0.219	T	T	T	0.075	0.475	0.200	0.252	T	T	T	T	T	T	1.535	15.960	0.974	D	N	-0.485	1.207	-0.441	1.300	1.000	0.672	0.522	0.702	0.655	.	4.850	0.179	2.252	1.176	0.676	1.000	0.954	0.252	639	.	.	.	.	ITM2C	79	0	140	24	0.146341463414634	TRUE	NA
ENSG00000145147.20	.	BCM	GRCh38.p13	chr4	20553952	20553952	+	A	A	T	Missense_Mutation	SNP	ENST00000504154.6	exon26	c.A2709T	p.K903N	exonic	ENSG00000145147.20	.	nonsynonymous SNV	ENSG00000145147.20:ENST00000504154.6:exon26:c.A2709T:p.K903N	4p15.31	C3N-03039	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	L	D	N	0.593	T	T	D	0.270	0.530	0.658	1.134	D	T	T	T	T	D	2.656	22.700	0.998	D	D	-0.062	2.299	0.013	2.404	0.998	0.706	0.574	0.659	0.613	.	5.270	2.850	2.904	1.312	0.691	1.000	1.000	0.997	818	Cysteine-rich_flanking_region,_C-terminal	.	.	.	SLIT2	84	0	108	24	0.181818181818182	TRUE	TRUE
ENSG00000145642.12	.	BCM	GRCh38.p13	chr5	64690678	64690678	+	G	G	T	Missense_Mutation	SNP	ENST00000389074.6	exon1	c.G55T	p.V19L	exonic	ENSG00000145642.12	.	nonsynonymous SNV	ENSG00000145642.12:ENST00000389074.6:exon1:c.G55T:p.V19L	5q12.3	C3N-03039	0	0	0	0	0	0	0	0	rs747037670	9.17	D	D	.	.	D	D	.	T	N	0.367	T	T	D	0.275	0.707	0.277	0.511	T	T	D	T	D	T	4.224	28.900	0.998	D	D	0.532	5.291	0.590	6.096	1.000	0.447	0.563	0.504	0.555	.	4.950	4.950	7.000	1.097	0.586	1.000	1.000	0.999	614	.	.	.	.	SHISAL2B	98	0	106	20	0.158730158730159	TRUE	NA
ENSG00000164199.18	.	BCM	GRCh38.p13	chr5	90811189	90811189	+	G	G	A	Missense_Mutation	SNP	ENST00000405460.9	exon74	c.G15929A	p.R5310H	exonic	ENSG00000164199.18	.	nonsynonymous SNV	ENSG00000164199.18:ENST00000405460.9:exon74:c.G15929A:p.R5310H	5q14.3	C3N-03039	5.138e-05	0.0001	0	0.0001	0	1.546e-05	0	0.0002	rs368944647	0.19	T	T	B	B	N	N	.	T	N	0.038	T	T	T	0.082	.	0.067	0.056	T	T	T	T	T	T	0.670	8.177	0.806	N	N	-1.299	0.165	-1.368	0.168	0.009	0.706	0.588	0.710	0.564	.	5.470	-6.140	-0.352	-0.628	-0.135	0.000	0.512	0.847	769	Na-Ca_exchanger/integrin-beta4	.	.	ID=COSV67987823;OCCURENCE=1(upper_aerodigestive_tract)	ADGRV1	133	1	186	41	0.180616740088106	TRUE	TRUE
ENSG00000146038.12	.	BCM	GRCh38.p13	chr6	24278177	24278177	+	G	G	A	Missense_Mutation	SNP	ENST00000378454.8	exon7	c.C794T	p.S265F	exonic	ENSG00000146038.12	.	nonsynonymous SNV	ENSG00000146038.12:ENST00000378454.8:exon7:c.C794T:p.S265F	6p22.3	C3N-03039	.	.	.	.	.	.	.	.	.	8.20	D	D	D	P	D	D	M	T	N	0.271	T	T	T	0.093	0.228	0.563	0.258	T	T	T	T	D	T	2.950	23.300	0.998	D	N	0.326	3.915	0.275	3.575	0.186	0.554	0.590	0.602	0.613	.	4.650	3.750	2.744	1.176	0.676	1.000	0.949	0.778	834	.	.	.	ID=COSV65830728;OCCURENCE=1(skin)	DCDC2	116	0	118	49	0.293413173652695	TRUE	TRUE
ENSG00000047932.14	.	BCM	GRCh38.p13	chr6	117602129	117602129	+	C	C	T	Missense_Mutation	SNP	ENST00000368498.7	exon1	c.G160A	p.E54K	exonic	ENSG00000047932.14	.	nonsynonymous SNV	ENSG00000047932.14:ENST00000368498.7:exon1:c.G160A:p.E54K	6q22.1	C3N-03039	.	.	.	.	.	.	.	.	.	11.19	D	D	D	P	D	D	M	T	N	0.913	T	T	D	0.164	0.389	0.353	1.284	.	T	T	T	D	D	4.291	29.500	0.999	D	D	0.664	6.644	0.650	6.918	1.000	0.442	0.522	0.522	0.562	.	5.710	4.840	7.336	1.026	0.599	1.000	1.000	0.995	809	.	.	.	.	GOPC	404	0	422	149	0.260945709281961	TRUE	TRUE
ENSG00000164880.16	.	BCM	GRCh38.p13	chr7	1499082	1499082	+	C	C	T	Missense_Mutation	SNP	ENST00000404767.8	exon8	c.G1030A	p.D344N	exonic	ENSG00000164880.16	.	nonsynonymous SNV	ENSG00000164880.16:ENST00000404767.8:exon8:c.G1030A:p.D344N	7p22.3	C3N-03039	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.800	T	T	T	0.174	.	0.369	.	T	D	T	T	D	D	3.433	24.500	0.999	D	D	0.771	8.235	0.732	8.390	1.000	0.632	0.698	0.723	0.563	.	5.280	5.280	7.721	1.022	0.594	1.000	0.993	0.974	817	.	.	.	.	INTS1	253	0	384	83	0.177730192719486	TRUE	TRUE
ENSG00000105997.22	.	BCM	GRCh38.p13	chr7	27110211	27110211	+	G	G	A	Missense_Mutation	SNP	ENST00000612286.4	exon3	c.C430T	p.P144S	exonic	ENSG00000105997.22	.	nonsynonymous SNV	ENSG00000105997.22:ENST00000612286.4:exon3:c.C430T:p.P144S	7p15.2	C3N-03039	8.247e-06	0	0	0.0001	0	0	0	0	rs375062129	2.20	T	T	B	B	N	D	L	T	N	0.332	T	T	T	0.052	0.254	0.330	0.973	T	T	T	T	T	T	2.009	19.330	0.841	D	N	-0.418	1.343	-0.161	1.882	1.000	0.490	0.547	0.596	0.662	.	5.830	4.950	2.884	1.176	0.676	1.000	1.000	0.991	422	.	.	.	.	HOXA3	276	0	359	124	0.256728778467909	TRUE	NA
ENSG00000106348.18	.	BCM	GRCh38.p13	chr7	128401085	128401085	+	G	G	A	Missense_Mutation	SNP	ENST00000338791.11	exon6	c.C434T	p.T145M	exonic	ENSG00000106348.18	.	nonsynonymous SNV	ENSG00000106348.18:ENST00000338791.11:exon6:c.C434T:p.T145M	7q32.1	C3N-03039	2.483e-05	0	0	0	0	3.01e-05	0	6.063e-05	rs750159508	15.20	D	T	P	B	D	D	M	T	D	0.819	D	T	D	0.619	0.357	0.930	0.848	D	D	D	D	D	D	3.425	24.500	0.996	D	D	0.490	4.962	0.558	5.735	1.000	0.719	0.723	0.644	0.714	.	4.950	4.950	9.945	1.176	0.676	1.000	0.975	0.939	480	IMP_dehydrogenase/GMP_reductase	.	.	.	IMPDH1	482	0	718	219	0.233724653148346	TRUE	NA
ENSG00000164741.15	.	BCM	GRCh38.p13	chr8	13401535	13401535	+	C	C	A	Nonsense_Mutation	SNP	ENST00000276297.9	exon3	c.G1108T	p.E370X	exonic	ENSG00000164741.15	.	stopgain	ENSG00000164741.15:ENST00000276297.9:exon3:c.G1108T:p.E370X	8p22	C3N-03039	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.832	.	.	.	.	.	.	.	.	.	D	D	.	.	8.374	42	0.998	D	N	1.133	19.055	0.987	18.057	1.000	0.615	0.574	0.547	0.655	.	5.490	5.490	6.461	1.026	0.599	1.000	0.973	0.923	925	.	.	.	.	DLC1	164	0	223	38	0.145593869731801	TRUE	TRUE
ENSG00000197892.13	.	BCM	GRCh38.p13	chr8	29071791	29071791	+	C	C	T	Missense_Mutation	SNP	ENST00000524189.6	exon39	c.G5047A	p.G1683R	exonic	ENSG00000197892.13	.	nonsynonymous SNV	ENSG00000197892.13:ENST00000524189.6:exon39:c.G5047A:p.G1683R	8p12	C3N-03039	.	.	.	.	.	.	.	.	.	2.18	T	T	.	.	N	N	M	T	N	0.157	T	T	D	0.072	.	0.709	0.286	T	T	T	T	T	T	0.578	7.298	0.889	N	N	-0.858	0.575	-0.867	0.665	0.999	0.609	0.602	0.769	0.605	.	4.870	3.060	1.331	-0.367	-0.259	0.105	0.001	0.001	643	.	.	.	.	KIF13B	404	0	397	142	0.263450834879406	TRUE	TRUE
ENSG00000165392.11	.	BCM	GRCh38.p13	chr8	31157425	31157425	+	C	C	G	Missense_Mutation	SNP	ENST00000298139.7	exon33	c.C3877G	p.Q1293E	exonic	ENSG00000165392.11	.	nonsynonymous SNV	ENSG00000165392.11:ENST00000298139.7:exon33:c.C3877G:p.Q1293E	8p12	C3N-03039	.	.	.	.	.	.	.	.	.	6.20	T	T	D	P	D	D	M	T	N	0.544	T	T	T	0.138	0.423	0.701	0.129	T	T	T	T	D	T	2.668	22.800	0.798	D	N	0.207	3.335	0.195	3.157	1.000	0.732	0.744	0.725	0.714	.	5.620	5.620	4.131	1.026	0.599	0.999	0.797	0.454	951	Helicase_Helix-turn-helix_domain	.	.	.	WRN	428	0	612	173	0.220382165605096	TRUE	TRUE
ENSG00000156471.13	.	BCM	GRCh38.p13	chr8	96295230	96295230	+	A	A	T	Missense_Mutation	SNP	ENST00000517309.6	exon5	c.A574T	p.I192F	exonic	ENSG00000156471.13	.	nonsynonymous SNV	ENSG00000156471.13:ENST00000517309.6:exon5:c.A574T:p.I192F	8q22.1	C3N-03039	.	.	.	.	.	.	.	.	.	14.20	D	T	P	P	D	D	M	T	D	0.803	T	T	D	0.583	0.681	0.499	2.089	D	D	D	D	D	D	4.070	27.500	0.988	D	D	0.681	6.856	0.657	7.016	1.000	0.706	0.725	0.710	0.714	.	4.710	4.710	9.246	1.312	0.756	1.000	1.000	0.999	851	.	.	.	.	PTDSS1	89	0	146	35	0.193370165745856	TRUE	TRUE
ENSG00000132549.18	.	BCM	GRCh38.p13	chr8	99853822	99853822	+	T	T	G	Missense_Mutation	SNP	ENST00000358544.6	exon56	c.T10508G	p.I3503S	exonic	ENSG00000132549.18	.	nonsynonymous SNV	ENSG00000132549.18:ENST00000358544.6:exon56:c.T10508G:p.I3503S	8q22.2	C3N-03039	.	.	.	.	.	.	.	.	.	12.20	D	D	D	P	N	D	M	T	N	0.791	T	T	D	0.428	0.545	0.922	0.269	T	T	D	D	D	D	3.748	25.600	0.990	D	D	0.464	4.768	0.509	5.241	1.000	0.707	0.725	0.659	0.636	.	5.670	5.670	7.255	1.138	0.665	1.000	0.988	0.950	465	.	.	.	.	VPS13B	384	0	592	160	0.212765957446809	TRUE	TRUE
ENSG00000129292.20	.	BCM	GRCh38.p13	chr8	132817447	132817447	+	G	G	A	Missense_Mutation	SNP	ENST00000395386.6	exon12	c.G1481A	p.R494H	exonic	ENSG00000129292.20	.	nonsynonymous SNV	ENSG00000129292.20:ENST00000395386.6:exon12:c.G1481A:p.R494H	8q24.22	C3N-03039	0.0002	0.0023	8.812e-05	0.0005	0	1.506e-05	0	0	rs35409494	1.19	T	T	B	B	.	D	N	T	N	0.122	T	T	T	0.039	.	0.123	0.346	T	T	T	T	T	T	-0.012	1.260	0.147	N	N	-0.993	0.411	-0.875	0.654	0.935	0.707	0.634	0.725	0.714	.	4.840	1.150	-0.659	0.326	-0.092	0.009	0.942	0.990	876	.	.	.	ID=COSV55190002;OCCURENCE=1(large_intestine)	PHF20L1	257	0	424	102	0.193916349809886	TRUE	TRUE
ENSG00000165113.13	.	BCM	GRCh38.p13	chr9	83739711	83739711	+	C	C	T	Missense_Mutation	SNP	ENST00000376371.7	exon13	c.G1087A	p.D363N	exonic	ENSG00000165113.13	.	nonsynonymous SNV	ENSG00000165113.13:ENST00000376371.7:exon13:c.G1087A:p.D363N	9q21.32	C3N-03039	.	.	.	.	.	.	.	.	rs554092166	5.19	D	T	B	B	D	D	N	.	N	0.228	T	T	T	0.118	0.226	0.283	0.085	T	T	T	T	T	D	2.405	22.100	0.997	D	N	0.015	2.566	0.190	3.136	0.847	0.638	0.670	0.653	0.668	.	6.170	5.280	3.091	1.026	0.599	1.000	0.990	0.994	972	.	.	.	ID=COSV64487280;OCCURENCE=1(soft_tissue)	GKAP1	161	0	189	57	0.231707317073171	TRUE	NA
ENSG00000122877.16	.	BCM	GRCh38.p13	chr10	62813470	62813470	+	G	G	A	Missense_Mutation	SNP	ENST00000242480.4	exon2	c.C1168T	p.R390C	exonic	ENSG00000122877.16	.	nonsynonymous SNV	ENSG00000122877.16:ENST00000242480.4:exon2:c.C1168T:p.R390C	10q21.3	C3N-03039	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.834	T	T	D	0.632	0.797	0.788	2.275	D	D	D	D	D	D	4.796	33	0.999	D	D	0.955	12.555	0.876	12.777	1.000	0.765	0.686	0.732	0.479	.	5.020	5.020	9.986	1.176	0.676	1.000	1.000	0.997	874	Zinc_finger_C2H2-type	.	.	.	EGR2	244	0	413	55	0.117521367521368	TRUE	TRUE
ENSG00000171798.18	.	BCM	GRCh38.p13	chr10	133211763	133211763	+	G	G	A	Missense_Mutation	SNP	ENST00000304613.8	exon23	c.G4141A	p.G1381S	exonic	ENSG00000171798.18	.	nonsynonymous SNV	ENSG00000171798.18:ENST00000304613.8:exon23:c.G4141A:p.G1381S	10q26.3	C3N-03039	0.0001	0	0.0002	0	0	9.211e-05	0	0.0005	rs773807341	1.19	T	T	B	B	N	N	.	T	N	0.094	T	T	T	0.034	0.180	0.040	0.185	T	T	T	T	D	T	0.167	2.753	0.563	N	N	-1.784	0.025	-1.825	0.030	0.014	0.696	0.547	0.723	0.563	.	3.340	-2.440	-1.408	0.127	-0.207	0.000	0.013	0.001	990	.	.	.	ID=COSV100465233;OCCURENCE=1(cervix)	KNDC1	176	0	290	75	0.205479452054795	TRUE	NA
ENSG00000226288.2	.	BCM	GRCh38.p13	chr11	4587440	4587440	+	G	G	A	Missense_Mutation	SNP	ENST00000312614.4	exon1	c.G628A	p.E210K	exonic	ENSG00000226288.2	.	nonsynonymous SNV	ENSG00000226288.2:ENST00000312614.4:exon1:c.G628A:p.E210K	11p15.4	C3N-03039	0.0002	0	0.0008	0	0	0.0001	0	0.0002	rs753185432	10.20	D	D	D	D	D	D	H	T	D	0.614	T	T	T	0.392	0.560	0.506	0.767	T	T	T	T	D	T	3.422	24.500	0.999	D	N	0.709	7.244	0.605	6.283	1.000	0.554	0.590	0.618	0.542	.	4.180	4.180	2.769	1.165	0.590	1.000	0.996	0.939	851	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV57044357;OCCURENCE=1(large_intestine)	OR52I2	279	0	490	80	0.140350877192982	NA	TRUE
ENSG00000175097.8	.	BCM	GRCh38.p13	chr11	36593516	36593516	+	A	A	G	Missense_Mutation	SNP	ENST00000311485.8	exon2	c.T653C	p.I218T	exonic	ENSG00000175097.8	.	nonsynonymous SNV	ENSG00000175097.8:ENST00000311485.8:exon2:c.T653C:p.I218T	11p12	C3N-03039	.	.	.	.	.	.	.	.	.	16.19	D	D	D	P	D	D	M	T	D	0.819	D	D	D	0.827	0.715	0.943	0.454	T	D	D	D	D	D	3.779	25.700	0.997	D	.	0.849	9.823	0.797	10.036	1.000	0.497	0.563	0.547	0.542	.	5.700	5.700	8.947	1.312	0.756	1.000	0.998	0.971	367	.	.	.	.	RAG2	379	0	554	135	0.195936139332366	TRUE	TRUE
ENSG00000172188.5	.	BCM	GRCh38.p13	chr11	55603606	55603606	+	A	A	T	Nonsense_Mutation	SNP	ENST00000641580.1	exon4	c.T768A	p.Y256X	exonic	ENSG00000172188.5	.	stopgain	ENSG00000172188.5:ENST00000641580.1:exon4:c.T768A:p.Y256X	11q11	C3N-03039	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	U	D	.	.	.	0.051	.	.	.	.	.	.	.	.	.	D	D	.	.	2.867	23.100	0.934	N	N	-0.409	1.364	-0.784	0.780	0.000	0.487	0.574	0.574	0.564	.	4.340	-2.780	-0.270	0.157	-0.126	0.000	0.026	0.008	153	GPCR,_rhodopsin-like,_7TM	.	.	.	OR4C11	223	0	338	76	0.183574879227053	TRUE	TRUE
ENSG00000173898.13	.	BCM	GRCh38.p13	chr11	66708228	66708228	+	C	C	A	Missense_Mutation	SNP	ENST00000533211.5	exon12	c.G1263T	p.E421D	exonic	ENSG00000173898.13	.	nonsynonymous SNV	ENSG00000173898.13:ENST00000533211.5:exon12:c.G1263T:p.E421D	11q13.2	C3N-03039	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.657	D	D	D	0.690	0.504	0.916	1.782	T	D	D	T	D	D	3.806	25.900	0.997	D	D	0.777	8.341	0.663	7.108	1.000	0.672	0.610	0.702	0.655	.	4.620	3.680	3.341	0.947	0.599	1.000	1.000	0.998	233	.	.	.	.	SPTBN2	116	0	286	58	0.168604651162791	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-03039	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	240	0	421	101	0.193486590038314	TRUE	TRUE
ENSG00000174243.10	.	BCM	GRCh38.p13	chr12	48837015	48837015	+	G	G	A	Nonsense_Mutation	SNP	ENST00000308025.8	exon9	c.C889T	p.Q297X	exonic	ENSG00000174243.10	.	stopgain	ENSG00000174243.10:ENST00000308025.8:exon9:c.C889T:p.Q297X	12q13.12	C3N-03039	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.520	.	.	.	.	.	.	.	.	.	D	D	.	.	7.207	37	0.998	D	N	1.189	22.729	1.056	22.826	1.000	0.707	0.702	0.702	0.714	.	5.690	5.690	9.852	1.176	0.676	1.000	0.997	0.986	578	.	.	.	.	DDX23	128	0	268	93	0.257617728531856	TRUE	TRUE
ENSG00000139329.5	.	BCM	GRCh38.p13	chr12	91104193	91104193	+	C	C	T	Missense_Mutation	SNP	ENST00000266718.5	exon3	c.G989A	p.R330H	exonic	ENSG00000139329.5	.	nonsynonymous SNV	ENSG00000139329.5:ENST00000266718.5:exon3:c.G989A:p.R330H	12q21.33	C3N-03039	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.629	T	T	D	0.336	0.431	0.617	1.315	T	D	D	T	D	D	4.124	28.000	1.000	D	D	0.728	7.525	0.668	7.190	1.000	0.487	0.547	0.574	0.564	.	5.180	5.180	7.042	1.008	0.549	1.000	0.999	0.957	892	.	.	.	ID=COSV57127852;OCCURENCE=1(endometrium)	LUM	143	0	230	70	0.233333333333333	TRUE	TRUE
ENSG00000152213.4	.	BCM	GRCh38.p13	chr13	49630637	49630637	+	G	G	A	Missense_Mutation	SNP	ENST00000282026.2	exon2	c.G190A	p.V64I	exonic	ENSG00000152213.4	.	nonsynonymous SNV	ENSG00000152213.4:ENST00000282026.2:exon2:c.G190A:p.V64I	13q14.2	C3N-03039	0.0002	0.0024	0	0	0	1.5e-05	0.0011	0	rs143660006	0.20	T	T	B	B	N	N	L	T	N	0.060	T	T	T	0.070	.	0.271	0.147	T	T	T	T	T	T	0.473	6.217	0.964	N	N	-0.855	0.579	-0.823	0.725	1.000	0.651	0.709	0.565	0.620	.	5.310	0.498	0.769	-0.514	-0.119	0.487	0.071	0.519	414	Small_GTP-binding_protein_domain	.	.	ID=COSV56290987;OCCURENCE=1(large_intestine)	ARL11	279	0	350	113	0.244060475161987	TRUE	TRUE
ENSG00000178235.8	.	BCM	GRCh38.p13	chr13	83880531	83880531	+	G	G	A	Missense_Mutation	SNP	ENST00000377084.3	exon1	c.C977T	p.A326V	exonic	ENSG00000178235.8	.	nonsynonymous SNV	ENSG00000178235.8:ENST00000377084.3:exon1:c.C977T:p.A326V	13q31.1	C3N-03039	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	L	T	N	0.200	T	T	T	0.031	0.395	0.294	0.431	T	T	T	T	D	T	2.186	20.800	0.908	D	D	-0.368	1.454	-0.168	1.864	1.000	0.658	0.547	0.619	0.564	.	4.850	4.000	6.438	1.176	0.676	1.000	0.988	0.996	973	.	.	.	ID=COSV65675004;OCCURENCE=1(large_intestine),1(endometrium)	SLITRK1	192	0	289	43	0.129518072289157	TRUE	TRUE
ENSG00000254585.5	.	BCM	GRCh38.p13	chr15	23646983	23646983	+	C	C	G	Missense_Mutation	SNP	ENST00000650528.1	exon1	c.G760C	p.A254P	exonic	ENSG00000254585.5	.	nonsynonymous SNV	ENSG00000254585.5:ENST00000650528.1:exon1:c.G760C:p.A254P	15q11.2	C3N-03039	.	.	.	.	.	.	.	.	.	1.10	D	T	.	.	.	.	.	T	N	0.271	.	.	.	.	.	0.275	.	T	T	T	T	.	T	0.901	10.450	0.566	N	.	.	.	.	.	0.990	0.207	0.063	0.209	0.079	0.069	3.030	1.100	-0.097	0.078	-0.458	0.000	0.654	0.195	988	.	.	.	.	MAGEL2	199	0	292	90	0.235602094240838	TRUE	TRUE
ENSG00000103995.14	.	BCM	GRCh38.p13	chr15	48797331	48797331	+	T	T	A	Missense_Mutation	SNP	ENST00000380950.7	exon5	c.A510T	p.K170N	exonic	ENSG00000103995.14	.	nonsynonymous SNV	ENSG00000103995.14:ENST00000380950.7:exon5:c.A510T:p.K170N	15q21.1	C3N-03039	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.227	T	T	T	0.182	0.283	0.608	0.074	T	T	T	T	T	T	0.612	7.633	0.809	N	N	-1.379	0.126	-1.289	0.216	1.000	0.706	0.576	0.710	0.696	.	4.680	-0.255	-0.242	-0.636	-0.194	0.035	0.853	0.966	242	.	.	.	.	CEP152	182	0	312	71	0.185378590078329	TRUE	TRUE
ENSG00000074755.15	.	BCM	GRCh38.p13	chr17	4013573	4013573	+	C	C	A	Missense_Mutation	SNP	ENST00000381638.7	exon52	c.G8455T	p.V2819L	exonic	ENSG00000074755.15	.	nonsynonymous SNV	ENSG00000074755.15:ENST00000381638.7:exon52:c.G8455T:p.V2819L	17p13.2	C3N-03039	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.129	T	T	T	0.080	0.194	0.068	0.149	T	T	T	T	T	T	1.367	14.860	0.925	D	N	-0.330	1.541	-0.105	2.032	0.617	0.732	0.725	0.744	0.711	.	5.920	3.850	1.135	1.026	0.599	0.720	0.994	0.978	200	.	.	.	.	ZZEF1	147	0	175	83	0.321705426356589	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673802	7673802	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G818A	p.R273H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G818A:p.R273H	17p13.1	C3N-03039	2.628e-05	0	0	0	0	4.746e-05	0	0	rs28934576	19.20	D	D	D	D	D	A	M	D	D	0.965	D	D	D	0.868	.	0.997	0.264	T	D	D	D	D	D	3.527	24.800	0.998	D	D	0.383	4.238	0.333	3.915	1.000	0.722	0.702	0.725	0.735	.	4.920	4.920	7.905	1.022	0.596	1.000	0.856	0.980	432	p53,_DNA-binding_domain	.	.	ID=COSV52660980;OCCURENCE=3(salivary_gland),135(breast),5(penis),9(liver),2(genital_tract),55(oesophagus),3(adrenal_gland),1(cervix),301(large_intestine),84(central_nervous_system),18(biliary_tract),1(fallopian_tube),1(pleura),4(vulva),73(ovary),8(bone),6(NS),57(haematopoietic_and_lymphoid_tissue),60(stomach),23(urinary_tract),7(soft_tissue),9(kidney),55(pancreas),15(skin),22(prostate),111(lung),11(thyroid),66(upper_aerodigestive_tract),2(thymus),41(endometrium)	TP53	520	0	590	212	0.264339152119701	TRUE	TRUE
ENSG00000109072.14	.	BCM	GRCh38.p13	chr17	28369012	28369012	+	C	C	T	Missense_Mutation	SNP	ENST00000226218.9	exon5	c.G686A	p.R229H	exonic	ENSG00000109072.14	.	nonsynonymous SNV	ENSG00000109072.14:ENST00000226218.9:exon5:c.G686A:p.R229H	17q11.2	C3N-03039	8.331e-06	9.634e-05	0	0	0	0	0	0	rs782268632	14.20	D	D	D	D	D	D	H	T	D	0.810	T	T	D	0.426	0.775	0.449	0.888	T	T	T	D	D	D	4.350	30	0.999	D	D	1.096	17.341	1.002	18.957	1.000	0.421	0.551	0.537	0.613	.	5.740	5.740	7.560	1.016	0.587	1.000	1.000	0.998	127	Hemopexin-like_domain	.	.	ID=COSV56873113;OCCURENCE=1(stomach)	VTN	79	0	154	35	0.185185185185185	TRUE	TRUE
ENSG00000126562.17	.	BCM	GRCh38.p13	chr17	42785453	42785453	+	G	G	A	Missense_Mutation	SNP	ENST00000246914.10	exon6	c.G1447A	p.D483N	exonic	ENSG00000126562.17	.	nonsynonymous SNV	ENSG00000126562.17:ENST00000246914.10:exon6:c.G1447A:p.D483N	17q21.2	C3N-03039	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	N	D	L	T	D	0.587	T	T	D	0.428	0.415	0.941	0.630	T	T	T	T	D	D	4.497	32	0.999	D	D	0.641	6.364	0.642	6.790	1.000	0.583	0.457	0.578	0.621	.	5.020	5.020	9.999	1.176	0.618	1.000	0.994	0.991	239	Serine/threonine-protein_kinase_OSR1/WNK,_CCT_domain	.	.	.	WNK4	325	0	475	139	0.226384364820847	TRUE	TRUE
ENSG00000091583.11	.	BCM	GRCh38.p13	chr17	66226079	66226079	+	C	C	T	Missense_Mutation	SNP	ENST00000205948.11	exon3	c.G287A	p.R96H	exonic	ENSG00000091583.11	.	nonsynonymous SNV	ENSG00000091583.11:ENST00000205948.11:exon3:c.G287A:p.R96H	17q24.2	C3N-03039	1.652e-05	0	0	0	0	3.007e-05	0	0	rs138847585	4.20	T	T	B	B	N	D	N	T	N	0.312	T	T	T	0.065	.	0.368	0.240	T	T	T	T	T	D	2.628	22.700	0.983	D	D	-0.152	2.017	0.047	2.526	1.000	0.487	0.574	0.574	0.530	.	5.550	4.570	1.270	1.008	0.599	0.994	1.000	0.995	840	Sushi/SCR/CCP_domain	.	.	.	APOH	116	0	156	30	0.161290322580645	TRUE	NA
ENSG00000075643.6	.	BCM	GRCh38.p13	chr18	36203150	36203150	+	G	G	A	Missense_Mutation	SNP	ENST00000261326.6	exon5	c.G979A	p.A327T	exonic	ENSG00000075643.6	.	nonsynonymous SNV	ENSG00000075643.6:ENST00000261326.6:exon5:c.G979A:p.A327T	18q12.2	C3N-03039	5.766e-05	0	0	0	0	7.492e-05	0.0011	6.057e-05	rs199870151	15.20	D	D	D	P	D	D	H	D	N	0.786	D	D	T	0.635	.	0.978	0.429	T	T	D	D	D	D	3.419	24.500	0.999	D	D	0.658	6.568	0.517	5.321	1.000	0.706	0.547	0.710	0.595	.	5.670	5.670	6.524	1.176	0.676	1.000	0.041	0.028	864	Aminotransferase_class_V_domain	.	.	ID=COSV54341205;OCCURENCE=1(endometrium)	MOCOS	448	0	566	104	0.155223880597015	TRUE	TRUE
ENSG00000257704.4	.	BCM	GRCh38.p13	chr19	47275140	47275140	+	C	C	G	Missense_Mutation	SNP	ENST00000552360.4	exon1	c.C221G	p.P74R	exonic	ENSG00000257704.4	.	nonsynonymous SNV	ENSG00000257704.4:ENST00000552360.4:exon1:c.C221G:p.P74R	19q13.32	C3N-03039	.	.	.	.	.	.	.	.	.	2.17	D	T	B	B	.	N	.	.	N	0.082	T	T	D	0.021	0.210	0.110	.	T	T	T	T	T	T	0.681	8.280	0.831	N	N	-0.775	0.692	-0.810	0.744	1.000	0.652	0.484	0.641	0.492	.	2.780	1.710	0.485	-0.320	-1.063	0.000	0.038	0.009	721	.	.	.	.	INAFM1	255	0	362	93	0.204395604395604	TRUE	TRUE
ENSG00000088053.11	.	BCM	GRCh38.p13	chr19	55014974	55014974	+	C	C	T	Missense_Mutation	SNP	ENST00000417454.5	exon8	c.G967A	p.G323R	exonic	ENSG00000088053.11	.	nonsynonymous SNV	ENSG00000088053.11:ENST00000417454.5:exon8:c.G967A:p.G323R	19q13.42	C3N-03039	0.0026	0.0282	0.0014	0.0019	0.0002	0.0001	0.0011	0	rs80348265	2.15	D	D	B	B	.	N	.	T	N	0.177	T	T	.	0.019	.	0.136	0.579	T	.	T	T	T	.	0.841	9.806	0.893	N	N	-1.175	0.245	-1.319	0.197	1.000	0.487	0.574	0.514	0.649	.	2.250	-1.900	-0.449	-0.834	-0.845	0.000	0.000	0.000	976	.	.	.	.	GP6	507	0	486	74	0.132142857142857	TRUE	NA
ENSG00000179709.8	.	BCM	GRCh38.p13	chr19	55955340	55955340	+	G	G	A	Missense_Mutation	SNP	ENST00000291971.7	exon3	c.G1282A	p.V428I	exonic	ENSG00000179709.8	.	nonsynonymous SNV	ENSG00000179709.8:ENST00000291971.7:exon3:c.G1282A:p.V428I	19q13.43	C3N-03039	8.238e-06	0	0	0	0	1.499e-05	0	0	rs759351908	1.19	T	T	P	B	.	N	N	D	N	0.023	T	T	T	0.236	0.567	0.288	0.064	T	T	T	T	T	T	0.605	7.564	0.527	N	N	-1.094	0.312	-1.280	0.223	0.000	0.487	0.574	0.547	0.564	.	1.780	-1.960	-0.171	-0.737	-0.227	0.000	0.009	0.012	946	.	.	.	ID=COSV52585627;OCCURENCE=1(adrenal_gland),2(large_intestine),2(stomach),1(soft_tissue),1(kidney),2(upper_aerodigestive_tract)	NLRP8	289	0	491	143	0.225552050473186	TRUE	TRUE
ENSG00000183579.16	.	BCM	GRCh38.p13	chr22	28883969	28883969	+	C	C	G	Missense_Mutation	SNP	ENST00000544604.7	exon1	c.C203G	p.S68W	exonic	ENSG00000183579.16	.	nonsynonymous SNV	ENSG00000183579.16:ENST00000544604.7:exon1:c.C203G:p.S68W	22q12.1	C3N-03039	.	.	.	.	.	.	.	.	.	8.17	D	D	.	.	.	D	N	T	N	0.465	T	T	D	0.126	0.395	0.043	1.358	D	T	T	T	D	D	3.368	24.300	0.987	D	N	-0.046	2.351	-0.048	2.201	1.000	0.437	0.607	0.520	0.619	.	2.930	1.800	4.385	-0.079	0.354	1.000	0.888	0.992	463	.	.	.	.	ZNRF3	265	0	341	92	0.212471131639723	TRUE	TRUE
ENSG00000188408.5	.	BCM	GRCh38.p13	chrX	26217519	26217519	+	G	G	A	Missense_Mutation	SNP	ENST00000602297.1	exon2	c.G218A	p.R73K	exonic	ENSG00000188408.5	.	nonsynonymous SNV	ENSG00000188408.5:ENST00000602297.1:exon2:c.G218A:p.R73K	Xp21.3	C3N-03039	.	.	.	.	.	.	.	.	.	0.15	.	T	.	.	N	N	N	T	.	0.093	T	T	T	0.016	.	0.040	0.045	T	T	T	T	T	T	-1.042	0.006	0.409	N	.	.	.	.	.	0.044	.	.	.	.	.	4.060	-7.710	-0.337	-0.280	-0.940	0.000	0.000	0.000	719	MAGE_homology_domain	.	.	.	MAGEB5	135	0	278	42	0.13125	TRUE	TRUE
ENSG00000189037.8	.	BCM	GRCh38.p13	chrX	44844647	44844647	+	C	C	T	Missense_Mutation	SNP	ENST00000339042.6	exon1	c.C515T	p.P172L	exonic	ENSG00000189037.8	.	nonsynonymous SNV	ENSG00000189037.8:ENST00000339042.6:exon1:c.C515T:p.P172L	Xp11.3	C3N-03039	2.333e-05	0	0.0002	0	0	0	0	0	.	6.19	D	T	P	B	N	N	M	T	D	0.135	T	T	D	0.159	0.482	0.305	0.620	T	T	T	T	D	T	1.592	16.320	0.933	D	.	.	.	.	.	1.000	.	.	.	.	.	3.950	-0.109	4.976	-0.268	-0.171	0.976	0.005	0.036	654	.	.	.	.	DUSP21	110	0	207	39	0.158536585365854	TRUE	NA
ENSG00000147162.14	.	BCM	GRCh38.p13	chrX	71537960	71537960	+	G	G	A	Missense_Mutation	SNP	ENST00000373719.8	exon3	c.G350A	p.R117H	exonic	ENSG00000147162.14	.	nonsynonymous SNV	ENSG00000147162.14:ENST00000373719.8:exon3:c.G350A:p.R117H	Xq13.1	C3N-03039	.	.	.	.	.	.	.	.	.	11.19	D	D	D	P	D	D	L	T	D	0.565	T	T	D	0.308	0.393	0.817	1.868	D	T	T	T	D	D	3.540	24.800	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.860	4.860	9.620	1.176	0.672	1.000	1.000	0.998	218	Tetratricopeptide_repeat-containing_domain	.	.	ID=COSV65480952;OCCURENCE=1(breast),1(large_intestine),1(pancreas)	OGT	302	0	423	109	0.204887218045113	TRUE	TRUE
ENSG00000147234.10	.	BCM	GRCh38.p13	chrX	107563177	107563177	+	G	G	A	Missense_Mutation	SNP	ENST00000276185.8	exon12	c.G1192A	p.V398I	exonic	ENSG00000147234.10	.	nonsynonymous SNV	ENSG00000147234.10:ENST00000276185.8:exon12:c.G1192A:p.V398I	Xq22.3	C3N-03039	.	.	.	.	.	.	.	.	.	5.16	T	T	.	.	D	N	N	T	N	0.344	T	T	D	0.326	0.498	0.927	2.054	.	T	T	T	D	D	2.179	20.700	0.990	D	.	.	.	.	.	1.000	.	.	.	.	.	5.870	5.000	4.513	1.176	0.676	1.000	0.995	0.997	30	0.000	.	.	.	FRMPD3	193	0	326	63	0.161953727506427	TRUE	TRUE
ENSG00000038210.14	.	BCM	GRCh38.p13	chr4	25256541	25256541	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000038210.14	ENST00000264864.8:exon4:c.625-2A>G	.	.	4p15.2	C3N-03039	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.601	34	0.996	D	.	1.200	23.665	1.066	23.615	1.000	0.295	0.304	0.060	0.110	0.983	6.070	6.070	9.169	1.312	0.750	1.000	1.000	0.958	659	.	.	.	.	PI4K2B	62	0	128	40	0.238095238095238	TRUE	TRUE
ENSG00000106799.13	.	BCM	GRCh38.p13	chr9	99146483	99146483	+	A	A	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000106799.13	ENST00000374994.9:exon7:c.1131-2A>T	.	.	9q22.33	C3N-03039	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.515	34	0.995	D	.	1.147	19.829	1.000	18.845	1.000	0.156	0.156	0.121	0.088	0.975	5.430	5.430	9.325	1.312	0.691	1.000	1.000	0.996	475	.	.	.	.	TGFBR1	391	0	431	174	0.287603305785124	NA	TRUE
ENSG00000120332.16	.	BCM	GRCh38.p13	chr1	175097673	175097673	+	C	C	T	Silent	SNP	ENST00000239462.9	exon8	c.C1845T	p.N615N	exonic	ENSG00000120332.16	.	synonymous SNV	ENSG00000120332.16:ENST00000239462.9:exon8:c.C1845T:p.N615N	1q25.1	C3N-03039	0.0002	9.771e-05	0.0002	0.0002	0	0.0001	0.0011	0.0005	rs564187493	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53437634;OCCURENCE=1(liver),1(endometrium)	TNN	233	0	328	169	0.340040241448692	TRUE	TRUE
ENSG00000153230.4	.	BCM	GRCh38.p13	chr1	247738719	247738719	+	G	G	A	Silent	SNP	ENST00000283225.2	exon1	c.G105A	p.T35T	exonic	ENSG00000153230.4	.	synonymous SNV	ENSG00000153230.4:ENST00000283225.2:exon1:c.G105A:p.T35T	1q44	C3N-03039	0.0001	0	0	0.0015	0	0	0	0	rs560139926	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR14K1	164	0	305	132	0.302059496567506	TRUE	NA
ENSG00000135632.12	.	BCM	GRCh38.p13	chr2	73218920	73218920	+	G	G	A	Silent	SNP	ENST00000389501.9	exon2	c.G156A	p.R52R	exonic	ENSG00000135632.12	.	synonymous SNV	ENSG00000135632.12:ENST00000389501.9:exon2:c.G156A:p.R52R	2p13.2	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMYD5	218	0	425	97	0.185823754789272	TRUE	TRUE
ENSG00000134352.20	.	BCM	GRCh38.p13	chr5	55957242	55957242	+	A	A	C	Silent	SNP	ENST00000381298.7	exon9	c.T1023G	p.T341T	exonic	ENSG00000134352.20	.	synonymous SNV	ENSG00000134352.20:ENST00000381298.7:exon9:c.T1023G:p.T341T	5q11.2	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IL6ST	80	0	139	23	0.141975308641975	TRUE	TRUE
ENSG00000164325.8	.	BCM	GRCh38.p13	chr5	73173570	73173570	+	G	G	A	Silent	SNP	ENST00000296776.6	exon1	c.G327A	p.P109P	exonic	ENSG00000164325.8	.	synonymous SNV	ENSG00000164325.8:ENST00000296776.6:exon1:c.G327A:p.P109P	5q13.2	C3N-03039	3.295e-05	0	0	0.0001	0	4.495e-05	0	0	rs770962988	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57114477;OCCURENCE=1(breast),1(stomach),1(endometrium)	TMEM174	537	0	795	116	0.127332601536773	TRUE	TRUE
ENSG00000157680.15	.	BCM	GRCh38.p13	chr7	137407879	137407879	+	G	G	A	Silent	SNP	ENST00000288490.9	exon31	c.C2940T	p.D980D	exonic	ENSG00000157680.15	.	synonymous SNV	ENSG00000157680.15:ENST00000288490.9:exon31:c.C2940T:p.D980D	7q33	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DGKI	132	0	211	31	0.128099173553719	TRUE	TRUE
ENSG00000198879.12	.	BCM	GRCh38.p13	chr10	7171919	7171919	+	C	C	T	Silent	SNP	ENST00000397167.5	exon19	c.G2391A	p.P797P	exonic	ENSG00000198879.12	.	synonymous SNV	ENSG00000198879.12:ENST00000397167.5:exon19:c.G2391A:p.P797P	10p14	C3N-03039	0.0001	0.0007	0	0	0	0	0	0	rs568359802	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SFMBT2	48	0	93	20	0.176991150442478	TRUE	NA
ENSG00000183273.7	.	BCM	GRCh38.p13	chr12	119523813	119523813	+	C	C	A	Silent	SNP	ENST00000327554.3	exon11	c.C1224A	p.L408L	exonic	ENSG00000183273.7	.	synonymous SNV	ENSG00000183273.7:ENST00000327554.3:exon11:c.C1224A:p.L408L	12q24.23	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC60	186	1	283	88	0.237196765498652	TRUE	TRUE
ENSG00000126226.22	.	BCM	GRCh38.p13	chr13	113184455	113184455	+	A	A	T	Silent	SNP	ENST00000337344.9	exon9	c.T576A	p.I192I	exonic	ENSG00000126226.22	.	synonymous SNV	ENSG00000126226.22:ENST00000337344.9:exon9:c.T576A:p.I192I	13q34	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCID2	234	0	285	121	0.298029556650246	TRUE	TRUE
ENSG00000099812.9	.	BCM	GRCh38.p13	chr19	757435	757435	+	C	C	A	Silent	SNP	ENST00000215582.8	exon2	c.C489A	p.G163G	exonic	ENSG00000099812.9	.	synonymous SNV	ENSG00000099812.9:ENST00000215582.8:exon2:c.C489A:p.G163G	19p13.3	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MISP	276	0	406	125	0.235404896421846	TRUE	TRUE
ENSG00000167676.4	.	BCM	GRCh38.p13	chr19	4512916	4512916	+	G	G	T	Silent	SNP	ENST00000301286.4	exon3	c.C1002A	p.A334A	exonic	ENSG00000167676.4	.	synonymous SNV	ENSG00000167676.4:ENST00000301286.4:exon3:c.C1002A:p.A334A	19p13.3	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLIN4	333	0	563	131	0.188760806916427	NA	TRUE
ENSG00000186977.3	.	BCM	GRCh38.p13	chr21	30502052	30502052	+	G	G	A	Silent	SNP	ENST00000334151.3	exon1	c.C39T	p.Y13Y	exonic	ENSG00000186977.3	.	synonymous SNV	ENSG00000186977.3:ENST00000334151.3:exon1:c.C39T:p.Y13Y	21q22.11	C3N-03039	0.0003	9.61e-05	0.0003	0	0.0002	0.0004	0.0011	0.0003	rs367860556	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61858619;OCCURENCE=2(large_intestine),1(central_nervous_system),2(urinary_tract),1(prostate)	KRTAP19-5	441	2	521	133	0.203363914373089	TRUE	TRUE
ENSG00000223350.2	.	BCM	GRCh38.p13	chr22	22343253	22343253	+	C	C	T	Silent	SNP	ENST00000427632.2	exon1	c.C30T	p.L10L	exonic	ENSG00000223350.2	.	synonymous SNV	ENSG00000223350.2:ENST00000427632.2:exon1:c.C30T:p.L10L	22q11.22	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGLV9-49	207	0	374	47	0.111638954869359	TRUE	NA
ENSG00000166707.11	.	BCM	GRCh38.p13	chrX	104115212	104115212	+	C	C	T	Silent	SNP	ENST00000650639.1	exon3	c.C1101T	p.N367N	exonic	ENSG00000166707.11	.	synonymous SNV	ENSG00000166707.11:ENST00000650639.1:exon3:c.C1101T:p.N367N	Xq22.2	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZCCHC18	202	0	294	75	0.203252032520325	TRUE	TRUE
ENSG00000164252.13	.	BCM	GRCh38.p13	chr5	77030433	77030438	+	GCTGGA	GCTGGA	-	5'UTR	DEL	NA	NA	NA	NA	UTR5	ENSG00000164252.13	ENST00000312916.12:c.-334_-329del-	.	.	5q13.3	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AGGF1	130	0	183	39	0.175675675675676	TRUE	NA
ENSG00000169919.17	.	BCM	GRCh38.p13	chr7	65975950	65975950	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000169919.17	.	.	.	7q11.21	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GUSB	31	0	85	13	0.13265306122449	TRUE	NA
ENSG00000181800.6	.	BCM	GRCh38.p13	chr10	11318868	11318868	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000181800.6	.	.	.	10p14	C3N-03039	0.0002	0	0	0	0	0	0	0.0004	rs766318093	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CELF2-AS1	347	0	557	146	0.207681365576102	TRUE	NA
ENSG00000241749.4	.	BCM	GRCh38.p13	chr12	65758428	65758428	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000241749.4	.	.	.	12q14.3	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RPSAP52	199	1	338	86	0.202830188679245	TRUE	NA
ENSG00000279640.1	.	BCM	GRCh38.p13	chr12	132104245	132104245	+	C	C	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000279640.1;ENSG00000185684.15	dist=3425;dist=13901	.	.	12q24.33	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC138466.5	210	0	333	82	0.197590361445783	TRUE	NA
ENSG00000105426.17	.	BCM	GRCh38.p13	chr19	5257432	5257432	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000105426.17	.	.	.	19p13.3	C3N-03039	7.931e-05	0.0017	0	0	0	0	0	0	rs753048666	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTPRS	210	0	316	66	0.172774869109948	TRUE	NA
ENSG00000199030.2	.	BCM	GRCh38.p13	chr21	16539858	16539858	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000199030.2	.	.	.	21q21.1	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIRLET7C	86	1	118	25	0.174825174825175	TRUE	NA
ENSG00000081853.15	.	BCM	GRCh38.p13	chr5	141339430	141339431	+	TC	TC	AG	Unknown	MNP	ENST00000394576.3	exon1	c.459_460delinsAG	p.L154V	exonic	ENSG00000081853.15	.	nonframeshift substitution	ENSG00000081853.15:ENST00000394576.3:exon1:c.459_460delinsAG:p.L154V	5q31.3	C3N-03039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHGA2	166	32	268	36	0.118421052631579	TRUE	TRUE
ENSG00000187862.12	.	BCM	GRCh38.p13	chr1	156581707	156581707	+	C	C	T	Nonsense_Mutation	SNP	ENST00000368236.7	exon2	c.C343T	p.R115X	exonic	ENSG00000187862.12	.	stopgain	ENSG00000187862.12:ENST00000368236.7:exon2:c.C343T:p.R115X	1q22	C3N-03086	.	.	.	.	.	.	.	.	rs765487668	1.6	.	.	.	.	N	A	.	.	.	0.068	.	.	.	.	.	.	.	.	.	T	T	.	.	3.315	24.200	0.899	N	N	-0.540	1.099	-1.010	0.477	1.000	0.497	0.492	0.489	0.542	.	4.540	-9.070	-1.325	-1.159	-0.171	0.000	0.006	0.201	693	Tetratricopeptide_repeat-containing_domain	.	.	.	TTC24	443	0	417	179	0.300335570469799	TRUE	NA
ENSG00000075340.23	.	BCM	GRCh38.p13	chr2	70706395	70706395	+	G	G	A	Missense_Mutation	SNP	ENST00000264436.9	exon3	c.C14T	p.T5M	exonic	ENSG00000075340.23	.	nonsynonymous SNV	ENSG00000075340.23:ENST00000264436.9:exon3:c.C14T:p.T5M	2p13.3	C3N-03086	.	.	.	.	.	.	.	.	rs782403508	5.20	D	D	P	B	N	N	L	T	D	0.290	T	T	T	0.146	0.088	0.432	0.551	T	T	T	T	D	D	2.035	19.520	0.993	N	N	-0.183	1.924	-0.168	1.863	0.999	0.675	0.574	0.693	0.564	.	5.640	3.740	0.829	1.176	0.618	0.019	0.084	0.959	798	.	.	.	ID=COSV52459544;OCCURENCE=2(large_intestine)	ADD2	147	0	120	19	0.136690647482014	TRUE	TRUE
ENSG00000064933.18	.	BCM	GRCh38.p13	chr2	189805662	189805662	+	C	C	T	Missense_Mutation	SNP	ENST00000441310.7	exon4	c.C326T	p.T109I	exonic	ENSG00000064933.18	.	nonsynonymous SNV	ENSG00000064933.18:ENST00000441310.7:exon4:c.C326T:p.T109I	2q32.2	C3N-03086	.	.	.	.	.	.	.	.	.	11.20	D	T	B	B	N	D	N	D	D	0.360	D	D	D	0.279	0.462	0.963	0.144	T	D	T	T	D	D	2.927	23.300	0.970	D	N	0.043	2.669	0.197	3.169	0.964	0.732	0.744	0.710	0.728	.	5.860	4.980	3.919	1.026	0.594	1.000	1.000	0.997	711	DNA_mismatch_repair_protein_family,_N-terminal	.	.	.	PMS1	308	0	194	20	0.0934579439252336	TRUE	TRUE
ENSG00000204120.15	.	BCM	GRCh38.p13	chr2	232819840	232819840	+	G	G	T	Missense_Mutation	SNP	ENST00000373563.9	exon21	c.G2384T	p.R795L	exonic	ENSG00000204120.15	.	nonsynonymous SNV	ENSG00000204120.15:ENST00000373563.9:exon21:c.G2384T:p.R795L	2q37.1	C3N-03086	.	.	.	.	.	.	.	.	.	12.19	D	D	D	P	D	D	.	T	D	0.684	T	T	D	0.359	0.361	0.276	0.375	D	T	T	T	D	D	4.008	27.000	0.993	D	D	0.428	4.522	0.467	4.875	0.999	0.732	0.725	0.744	0.728	.	5.040	5.040	6.439	1.176	0.676	1.000	0.989	0.955	810	.	.	.	.	GIGYF2	182	0	140	18	0.113924050632911	TRUE	TRUE
ENSG00000113916.18	.	BCM	GRCh38.p13	chr3	187733551	187733551	+	G	G	A	Missense_Mutation	SNP	ENST00000406870.7	exon3	c.C143T	p.T48M	exonic	ENSG00000113916.18	.	nonsynonymous SNV	ENSG00000113916.18:ENST00000406870.7:exon3:c.C143T:p.T48M	3q27.3	C3N-03086	0.0002	0.0003	0.0012	0	0	5.996e-05	0	6.056e-05	rs200263685	14.20	D	D	D	D	D	D	L	T	D	0.733	T	T	D	0.437	.	0.819	2.459	D	D	T	D	T	D	4.229	28.900	0.999	D	D	0.578	5.706	0.678	7.365	1.000	0.707	0.563	0.725	0.714	.	5.700	5.700	9.362	1.176	0.676	1.000	1.000	0.995	950	BTB/POZ_domain	.	.	ID=COSV51655708;OCCURENCE=1(oesophagus)	BCL6	203	0	184	28	0.132075471698113	TRUE	TRUE
ENSG00000138759.19	.	BCM	GRCh38.p13	chr4	78369932	78369932	+	C	C	G	Nonsense_Mutation	SNP	ENST00000512123.4	exon23	c.C2817G	p.Y939X	exonic	ENSG00000138759.19	.	stopgain	ENSG00000138759.19:ENST00000512123.4:exon23:c.C2817G:p.Y939X	4q21.21	C3N-03086	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.908	.	.	.	.	.	.	.	.	.	D	D	.	.	6.122	35	0.996	D	N	0.071	2.772	-0.170	1.858	1.000	0.742	0.590	0.775	0.621	.	4.580	-0.790	-0.127	-1.315	-0.919	0.826	0.028	0.025	904	.	.	.	.	FRAS1	142	0	72	7	0.0886075949367089	TRUE	TRUE
ENSG00000145388.15	.	BCM	GRCh38.p13	chr4	118687973	118687973	+	T	T	-	Frame_Shift_Del	NA	ENST00000388822.10	exon2	c.117delT	p.D39Efs*46	exonic	ENSG00000145388.15	.	frameshift deletion	ENSG00000145388.15:ENST00000388822.10:exon2:c.117delT:p.D39Efs*46	4q26	C3N-03086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	METTL14	296	0	158	19	0.107344632768362	TRUE	TRUE
ENSG00000145388.15	.	BCM	GRCh38.p13	chr4	118705648	118705648	+	G	G	A	Missense_Mutation	SNP	ENST00000388822.10	exon10	c.G893A	p.R298H	exonic	ENSG00000145388.15	.	nonsynonymous SNV	ENSG00000145388.15:ENST00000388822.10:exon10:c.G893A:p.R298H	4q26	C3N-03086	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	H	T	D	0.735	D	T	D	0.545	0.885	0.708	1.944	D	T	T	T	D	D	4.405	31	0.999	D	D	0.926	11.732	0.853	11.888	1.000	0.732	0.725	0.744	0.714	.	5.820	4.980	9.352	1.176	0.618	1.000	0.987	0.998	888	.	.	.	ID=COSV66310354;OCCURENCE=3(oesophagus),1(cervix),1(biliary_tract),1(stomach),4(pancreas),1(upper_aerodigestive_tract)	METTL14	238	0	124	22	0.150684931506849	TRUE	TRUE
ENSG00000182836.10	.	BCM	GRCh38.p13	chr5	41382120	41382120	+	G	G	T	Missense_Mutation	SNP	ENST00000377801.8	exon2	c.C518A	p.A173E	exonic	ENSG00000182836.10	.	nonsynonymous SNV	ENSG00000182836.10:ENST00000377801.8:exon2:c.C518A:p.A173E	5p13.1	C3N-03086	.	.	.	.	.	.	.	.	.	5.20	T	T	P	B	D	D	L	T	N	0.530	T	T	T	0.149	0.464	0.574	0.120	T	T	T	T	T	D	2.011	19.340	0.957	D	D	0.151	3.091	0.302	3.727	0.998	0.487	0.574	0.574	0.564	.	5.810	5.810	5.140	1.176	0.676	1.000	0.997	0.997	638	Phosphatidylinositol-specific_phospholipase_C,_X_domain	.	.	.	PLCXD3	272	0	188	25	0.117370892018779	TRUE	TRUE
ENSG00000120137.7	.	BCM	GRCh38.p13	chr5	168566244	168566244	+	T	T	C	Missense_Mutation	SNP	ENST00000239231.7	exon3	c.A404G	p.K135R	exonic	ENSG00000120137.7	.	nonsynonymous SNV	ENSG00000120137.7:ENST00000239231.7:exon3:c.A404G:p.K135R	5q34	C3N-03086	8.275e-06	0	0	0	0	1.505e-05	0	0	rs745504130	16.20	D	D	P	P	D	D	L	D	D	0.670	D	D	D	0.825	0.659	0.970	1.228	T	D	D	D	D	D	3.916	26.400	0.999	D	D	0.399	4.339	0.465	4.856	1.000	0.707	0.654	0.696	0.714	.	5.070	5.070	8.017	1.138	0.665	1.000	1.000	1.000	974	.	.	.	.	PANK3	115	1	63	4	0.0597014925373134	TRUE	NA
ENSG00000204703.5	.	BCM	GRCh38.p13	chr6	29086549	29086549	+	G	G	A	Missense_Mutation	SNP	ENST00000377173.4	exon1	c.C700T	p.R234W	exonic	ENSG00000204703.5	.	nonsynonymous SNV	ENSG00000204703.5:ENST00000377173.4:exon1:c.C700T:p.R234W	6p22.1	C3N-03086	3.297e-05	9.625e-05	0	0.0001	0	1.499e-05	0	6.059e-05	rs747253516	6.19	D	T	D	D	U	N	M	T	D	0.240	T	T	T	0.064	.	0.547	0.153	T	T	T	T	D	.	2.558	22.500	0.998	N	N	0.004	2.524	-0.229	1.717	0.000	0.487	0.574	0.574	0.564	.	3.820	1.310	-1.450	0.671	0.564	0.000	0.846	0.544	754	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV65850780;OCCURENCE=1(central_nervous_system)	OR2B3	152	0	99	27	0.214285714285714	TRUE	TRUE
ENSG00000065060.17	.	BCM	GRCh38.p13	chr6	34821813	34821813	+	C	C	T	Missense_Mutation	SNP	ENST00000192788.6	exon2	c.C205T	p.R69W	exonic	ENSG00000065060.17	.	nonsynonymous SNV	ENSG00000065060.17:ENST00000192788.6:exon2:c.C205T:p.R69W	6p21.31	C3N-03086	8.286e-06	0	0	0	0	1.499e-05	0	0	rs754882631	20.20	D	D	D	D	D	D	M	D	D	0.874	D	D	D	0.807	0.648	0.800	0.606	D	D	D	D	D	D	4.768	33	0.999	D	D	0.389	4.279	0.335	3.926	0.949	0.563	0.654	0.609	0.636	.	5.890	3.950	1.680	0.102	-0.224	1.000	0.996	0.923	290	Vacuolar_protein_sorting-associated_protein_13,_N-terminal_domain	.	.	.	UHRF1BP1	132	1	91	16	0.149532710280374	TRUE	NA
ENSG00000137270.11	.	BCM	GRCh38.p13	chr6	53128406	53128406	+	C	C	A	Missense_Mutation	SNP	ENST00000259803.8	exon6	c.G1111T	p.D371Y	exonic	ENSG00000137270.11	.	nonsynonymous SNV	ENSG00000137270.11:ENST00000259803.8:exon6:c.G1111T:p.D371Y	6p12.1	C3N-03086	.	.	.	.	.	.	.	.	.	8.20	D	T	D	P	N	D	M	T	N	0.478	T	T	D	0.306	0.471	0.539	0.450	T	T	D	T	D	T	2.692	22.800	0.995	D	N	0.454	4.697	0.473	4.926	0.028	0.497	0.590	0.547	0.542	.	5.730	5.730	1.041	1.026	0.549	0.855	0.863	0.884	618	.	.	.	.	GCM1	361	1	269	34	0.112211221122112	TRUE	TRUE
ENSG00000111879.20	.	BCM	GRCh38.p13	chr6	118980250	118980250	+	G	G	A	Missense_Mutation	SNP	ENST00000338891.12	exon10	c.C2189T	p.T730M	exonic	ENSG00000111879.20	.	nonsynonymous SNV	ENSG00000111879.20:ENST00000338891.12:exon10:c.C2189T:p.T730M	6q22.31	C3N-03086	8.293e-06	0	0	0	0	1.5e-05	0	0	rs773464428	8.20	T	T	D	D	D	D	L	T	N	0.527	T	T	T	0.197	0.101	0.655	0.623	T	T	T	T	D	D	3.355	24.300	0.999	D	D	0.724	7.471	0.766	9.179	1.000	0.693	0.574	0.659	0.564	.	6.170	6.170	5.739	1.172	0.672	1.000	0.978	0.964	610	.	.	.	ID=COSV58851698;OCCURENCE=1(salivary_gland),2(large_intestine),1(central_nervous_system),1(skin),1(lung)	FAM184A	295	0	288	39	0.119266055045872	TRUE	TRUE
ENSG00000118523.6	.	BCM	GRCh38.p13	chr6	131949476	131949476	+	G	G	A	Nonsense_Mutation	SNP	ENST00000367976.4	exon5	c.C838T	p.R280X	exonic	ENSG00000118523.6	.	stopgain	ENSG00000118523.6:ENST00000367976.4:exon5:c.C838T:p.R280X	6q23.2	C3N-03086	.	.	.	.	.	.	.	.	.	6.6	.	.	.	.	D	D	.	.	.	0.949	.	.	.	.	.	.	.	.	.	D	D	.	.	6.931	36	0.997	D	D	0.456	4.711	0.265	3.518	1.000	0.675	0.563	0.696	0.756	.	5.550	1.400	0.681	0.161	0.618	1.000	0.974	0.921	426	Glycoprotein_hormone_subunit_beta;Cystine_knot,_C-terminal	.	.	.	CCN2	434	1	343	45	0.115979381443299	TRUE	TRUE
ENSG00000078549.14	.	BCM	GRCh38.p13	chr7	31086976	31086976	+	C	C	T	Missense_Mutation	SNP	ENST00000304166.8	exon11	c.C857T	p.T286M	exonic	ENSG00000078549.14	.	nonsynonymous SNV	ENSG00000078549.14:ENST00000304166.8:exon11:c.C857T:p.T286M	7p14.3	C3N-03086	0.0001	0	0	0.0003	0	5.993e-05	0	0.0004	rs200730426	1.20	T	D	B	B	N	N	N	T	N	0.263	T	T	T	0.088	.	0.481	0.373	T	T	T	T	T	T	1.801	17.740	0.935	N	N	-0.861	0.571	-0.804	0.753	0.066	0.706	0.590	0.710	0.542	.	5.560	-0.273	2.332	-0.450	-0.171	0.042	0.077	0.344	939	GPCR,_family_2-like	.	.	ID=COSV58443069;OCCURENCE=1(large_intestine),2(pancreas),1(prostate)	ADCYAP1R1	254	0	222	22	0.0901639344262295	TRUE	TRUE
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	2998110	2998110	+	C	C	T	Missense_Mutation	SNP	ENST00000635120.2	exon54	c.G8278A	p.V2760M	exonic	ENSG00000183117.19	.	nonsynonymous SNV	ENSG00000183117.19:ENST00000635120.2:exon54:c.G8278A:p.V2760M	8p23.2	C3N-03086	0.0001	0.0001	0.0002	0.0003	0	0.0001	0	0	rs753927140	15.19	D	D	D	D	D	D	.	T	D	0.966	D	D	D	0.548	.	0.759	.	T	T	T	D	D	D	3.334	24.200	0.998	D	D	0.865	10.196	0.773	9.372	1.000	0.487	0.574	0.574	0.564	.	6.070	6.070	7.729	1.026	0.599	1.000	0.124	0.088	952	Sushi/SCR/CCP_domain	.	.	ID=COSV59279948;OCCURENCE=1(large_intestine),1(bone),2(endometrium)	CSMD1	232	0	221	27	0.108870967741935	TRUE	TRUE
ENSG00000169740.14	.	BCM	GRCh38.p13	chr10	43644427	43644427	+	C	C	T	Missense_Mutation	SNP	ENST00000374433.7	exon3	c.G445A	p.A149T	exonic	ENSG00000169740.14	.	nonsynonymous SNV	ENSG00000169740.14:ENST00000374433.7:exon3:c.G445A:p.A149T	10q11.21	C3N-03086	.	.	.	.	.	.	.	.	rs939183137	2.20	T	T	B	B	D	N	N	T	N	0.094	T	T	T	0.069	0.209	0.014	0.546	T	T	T	T	T	D	1.731	17.240	0.995	N	N	-0.452	1.274	-0.292	1.581	0.758	0.707	0.725	0.725	0.711	.	4.520	4.520	1.175	1.026	0.599	0.001	0.985	0.980	471	Zinc_finger_C2H2-type	.	.	.	ZNF32	187	0	139	18	0.114649681528662	TRUE	NA
ENSG00000176769.9	.	BCM	GRCh38.p13	chr10	131260339	131260339	+	G	G	A	Missense_Mutation	SNP	ENST00000368642.4	exon4	c.C776T	p.P259L	exonic	ENSG00000176769.9	.	nonsynonymous SNV	ENSG00000176769.9:ENST00000368642.4:exon4:c.C776T:p.P259L	10q26.3	C3N-03086	3.425e-05	0.0003	0	0	0	1.951e-05	0	0	rs535255286	1.20	T	T	B	B	N	N	N	T	D	0.212	T	T	T	0.040	.	0.214	0.114	T	T	T	T	T	T	1.447	15.400	0.511	N	N	-0.901	0.519	-0.837	0.706	0.003	0.646	0.588	0.645	0.564	.	5.200	1.550	2.247	-0.143	-0.791	0.987	0.018	0.003	979	.	.	.	.	TCERG1L	54	0	54	9	0.142857142857143	TRUE	NA
ENSG00000215182.8	.	BCM	GRCh38.p13	chr11	1192448	1192448	+	G	G	C	Missense_Mutation	SNP	ENST00000621226.2	exon31	c.G14303C	p.S4768T	exonic	ENSG00000215182.8	.	nonsynonymous SNV	ENSG00000215182.8:ENST00000621226.2:exon31:c.G14303C:p.S4768T	11p15.5	C3N-03086	0.0002	0	0	0	0.0003	0.0004	0	0	rs199611002	0.5	.	T	.	.	.	.	.	.	.	0.168	.	.	.	.	.	0.124	.	.	T	T	T	.	.	-0.728	0.038	0.314	N	.	.	.	.	.	0.146	0.057	0.061	0.074	0.079	0.056	2.790	-4.420	-0.383	-0.425	-3.270	0.000	0.000	0.000	.	.	.	.	ID=COSV64368850;OCCURENCE=1(oesophagus),1(biliary_tract),1(pancreas)	MUC5AC	237	0	265	35	0.116666666666667	TRUE	NA
ENSG00000187747.2	.	BCM	GRCh38.p13	chr11	5581136	5581136	+	C	C	T	Missense_Mutation	SNP	ENST00000345043.2	exon1	c.C260T	p.A87V	exonic	ENSG00000187747.2	.	nonsynonymous SNV	ENSG00000187747.2:ENST00000345043.2:exon1:c.C260T:p.A87V	11p15.4	C3N-03086	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	U	D	M	T	D	0.629	T	T	T	0.236	0.754	0.638	0.186	T	T	T	T	D	D	3.445	24.500	0.999	D	N	0.655	6.538	0.563	5.786	0.999	0.554	0.588	0.574	0.613	.	5.150	5.150	3.041	0.924	0.574	0.933	0.996	0.762	793	GPCR,_rhodopsin-like,_7TM	.	.	.	OR52B6	117	0	92	8	0.08	TRUE	TRUE
ENSG00000197136.4	.	BCM	GRCh38.p13	chr11	65618675	65618675	+	C	C	T	Missense_Mutation	SNP	ENST00000355703.3	exon6	c.C1313T	p.S438L	exonic	ENSG00000197136.4	.	nonsynonymous SNV	ENSG00000197136.4:ENST00000355703.3:exon6:c.C1313T:p.S438L	11q13.1	C3N-03086	1.684e-05	0.0001	0	0	0	1.533e-05	0	0	rs766222339	7.20	T	T	D	D	N	D	L	T	N	0.415	T	T	D	0.121	0.294	0.786	.	T	T	T	T	T	D	3.115	23.700	0.997	D	D	0.253	3.544	0.191	3.137	1.000	0.707	0.702	0.725	0.714	.	5.120	5.120	2.013	1.026	0.599	0.161	0.771	0.218	275	.	.	.	.	PCNX3	216	0	158	21	0.11731843575419	TRUE	NA
ENSG00000110237.5	.	BCM	GRCh38.p13	chr11	73363353	73363353	+	G	G	A	Missense_Mutation	SNP	ENST00000263674.4	exon15	c.G5144A	p.R1715H	exonic	ENSG00000110237.5	.	nonsynonymous SNV	ENSG00000110237.5:ENST00000263674.4:exon15:c.G5144A:p.R1715H	11q13.4	C3N-03086	.	.	.	.	.	.	.	.	rs1038055507	10.20	D	D	D	D	D	D	L	T	N	0.646	T	T	T	0.280	0.315	0.696	1.336	T	T	T	T	D	D	4.333	29.900	1.000	D	D	0.845	9.729	0.842	11.494	1.000	0.707	0.654	0.645	0.714	.	5.280	5.280	9.900	1.176	0.676	1.000	1.000	0.985	462	.	.	.	.	ARHGEF17	255	0	255	49	0.161184210526316	TRUE	NA
ENSG00000166004.15	.	BCM	GRCh38.p13	chr11	93706795	93706795	+	C	C	T	Nonsense_Mutation	SNP	ENST00000325212.11	exon18	c.C5647T	p.R1883X	exonic	ENSG00000166004.15	.	stopgain	ENSG00000166004.15:ENST00000325212.11:exon18:c.C5647T:p.R1883X	11q21	C3N-03086	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.238	.	.	.	.	.	.	.	.	.	D	D	.	.	7.787	39	0.998	D	N	0.562	5.553	0.392	4.301	0.000	0.651	0.654	0.651	0.684	.	5.140	3.150	1.337	-0.314	0.599	1.000	0.991	0.953	833	.	.	.	.	CEP295	137	1	87	13	0.13	TRUE	NA
ENSG00000149294.16	.	BCM	GRCh38.p13	chr11	113235153	113235153	+	C	C	T	Missense_Mutation	SNP	ENST00000316851.11	exon14	c.C1814T	p.T605M	exonic	ENSG00000149294.16	.	nonsynonymous SNV	ENSG00000149294.16:ENST00000316851.11:exon14:c.C1814T:p.T605M	11q23.2	C3N-03086	8.861e-06	0	0	0	0	1.605e-05	0	0	rs782353037	12.16	.	D	D	D	U	D	.	.	.	0.857	T	T	D	0.487	0.184	0.488	.	T	D	D	D	D	D	4.117	27.900	0.999	D	D	0.804	8.852	0.819	10.706	1.000	0.554	0.563	0.602	0.564	.	5.840	5.840	7.715	1.026	0.549	1.000	0.993	0.988	656	Fibronectin_type_III	.	.	ID=COSV57517108;OCCURENCE=1(cervix),4(large_intestine)	NCAM1	282	0	206	21	0.092511013215859	TRUE	TRUE
ENSG00000003056.8	.	BCM	GRCh38.p13	chr12	8941856	8941856	+	C	C	T	Missense_Mutation	SNP	ENST00000000412.8	exon7	c.G796A	p.E266K	exonic	ENSG00000003056.8	.	nonsynonymous SNV	ENSG00000003056.8:ENST00000000412.8:exon7:c.G796A:p.E266K	12p13.31	C3N-03086	1.647e-05	0	0	0	0	2.997e-05	0	0	rs780614862	9.20	D	D	P	B	D	D	M	T	N	0.368	T	T	T	0.138	0.588	0.314	0.438	T	T	T	T	D	D	3.330	24.200	0.999	D	D	0.447	4.652	0.549	5.637	1.000	0.719	0.723	0.698	0.711	.	5.810	5.810	5.664	1.013	0.599	1.000	1.000	0.999	673	.	.	.	.	M6PR	309	0	260	38	0.12751677852349	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-03086	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	312	0	203	51	0.200787401574803	TRUE	TRUE
ENSG00000206190.12	.	BCM	GRCh38.p13	chr15	25683470	25683470	+	A	A	G	Missense_Mutation	SNP	ENST00000555815.6	exon17	c.T3308C	p.L1103P	exonic	ENSG00000206190.12	.	nonsynonymous SNV	ENSG00000206190.12:ENST00000555815.6:exon17:c.T3308C:p.L1103P	15q12	C3N-03086	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.920	D	D	D	0.942	0.731	0.880	0.588	D	T	D	D	D	D	3.834	26.000	0.999	D	D	0.911	11.346	0.789	9.808	1.000	0.615	0.588	0.659	0.564	.	4.810	4.810	8.953	1.312	0.756	1.000	0.957	0.709	663	P-type_ATPase,_C-terminal	.	.	.	ATP10A	163	0	98	6	0.0576923076923077	TRUE	TRUE
ENSG00000188779.12	.	BCM	GRCh38.p13	chr15	67827113	67827113	+	G	G	A	Missense_Mutation	SNP	ENST00000380035.3	exon2	c.G1285A	p.G429S	exonic	ENSG00000188779.12	.	nonsynonymous SNV	ENSG00000188779.12:ENST00000380035.3:exon2:c.G1285A:p.G429S	15q23	C3N-03086	1.104e-05	0	0	0	0	1.943e-05	0	0	rs780509897	1.15	T	T	.	.	.	N	N	T	N	0.251	T	T	D	0.115	.	0.061	.	.	T	T	T	T	T	1.016	11.820	0.993	N	.	-0.590	1.006	-0.618	1.020	1.000	0.598	0.610	0.596	0.639	.	3.260	2.330	-0.142	0.097	-0.254	0.000	0.046	0.486	339	.	.	.	.	SKOR1	53	0	55	10	0.153846153846154	TRUE	NA
ENSG00000129009.13	.	BCM	GRCh38.p13	chr15	74175304	74175304	+	G	G	A	Missense_Mutation	SNP	ENST00000249842.8	exon2	c.G446A	p.R149H	exonic	ENSG00000129009.13	.	nonsynonymous SNV	ENSG00000129009.13:ENST00000249842.8:exon2:c.G446A:p.R149H	15q24.1	C3N-03086	1.651e-05	0	0	0	0	1.502e-05	0	6.075e-05	rs149796219	11.20	D	D	D	D	U	D	L	T	D	0.414	T	T	D	0.277	.	0.712	1.153	T	T	T	T	D	D	3.669	25.300	0.999	D	D	0.214	3.366	0.128	2.852	1.000	0.554	0.588	0.506	0.542	.	4.050	3.110	4.978	1.176	0.618	1.000	0.982	0.372	807	.	.	.	ID=COSV51433148;OCCURENCE=2(large_intestine),1(pancreas)	ISLR	245	1	216	35	0.139442231075697	TRUE	TRUE
ENSG00000141034.10	.	BCM	GRCh38.p13	chr17	18039595	18039595	+	G	G	C	Missense_Mutation	SNP	ENST00000268719.9	exon1	c.G131C	p.R44P	exonic	ENSG00000141034.10	.	nonsynonymous SNV	ENSG00000141034.10:ENST00000268719.9:exon1:c.G131C:p.R44P	17p11.2	C3N-03086	.	.	.	.	.	.	.	.	.	4.19	D	D	B	B	N	N	N	.	N	0.153	T	T	D	0.156	0.246	0.110	1.765	D	T	T	T	T	T	2.677	22.800	0.978	N	N	-0.744	0.740	-0.662	0.954	1.000	0.267	0.484	0.520	0.373	.	3.350	2.250	1.999	0.961	0.512	0.330	0.318	0.770	426	.	.	.	.	GID4	19	1	25	8	0.242424242424242	TRUE	NA
ENSG00000109103.12	.	BCM	GRCh38.p13	chr17	28547999	28547999	+	G	G	A	Missense_Mutation	SNP	ENST00000335765.9	exon3	c.C437T	p.T146M	exonic	ENSG00000109103.12	.	nonsynonymous SNV	ENSG00000109103.12:ENST00000335765.9:exon3:c.C437T:p.T146M	17q11.2	C3N-03086	1.66e-05	0	0	0	0	3.025e-05	0	0	rs767590360	18.20	D	D	D	D	D	D	M	T	D	0.850	D	D	D	0.718	0.552	0.932	1.280	T	D	D	D	D	D	4.938	33	0.999	D	D	0.959	12.684	0.932	15.189	1.000	0.744	0.522	0.780	0.584	.	5.770	5.770	10.003	1.172	0.672	1.000	1.000	0.991	245	GMP_phosphodiesterase,_delta_subunit	.	.	ID=COSV56379540;OCCURENCE=1(bone)	UNC119	326	0	247	25	0.0919117647058824	TRUE	TRUE
ENSG00000181481.14	.	BCM	GRCh38.p13	chr17	30971392	30971392	+	A	A	T	Missense_Mutation	SNP	ENST00000328381.10	exon1	c.A319T	p.S107C	exonic	ENSG00000181481.14	.	nonsynonymous SNV	ENSG00000181481.14:ENST00000328381.10:exon1:c.A319T:p.S107C	17q11.2	C3N-03086	.	.	.	.	.	.	.	.	.	2.20	D	T	B	B	N	N	N	T	N	0.163	T	T	D	0.039	0.352	0.307	0.178	T	T	T	T	T	T	0.253	3.744	0.662	N	N	-1.194	0.231	-1.298	0.210	1.000	0.267	0.484	0.474	0.373	.	0.787	-0.387	-2.869	-0.308	-0.344	0.000	0.002	0.002	721	.	.	.	.	RNF135	542	0	545	73	0.118122977346278	TRUE	TRUE
ENSG00000065989.16	.	BCM	GRCh38.p13	chr19	10420966	10420966	+	G	G	A	Missense_Mutation	SNP	ENST00000380702.7	exon1	c.G202A	p.A68T	exonic	ENSG00000065989.16	.	nonsynonymous SNV	ENSG00000065989.16:ENST00000380702.7:exon1:c.G202A:p.A68T	19p13.2	C3N-03086	.	.	.	.	.	.	.	.	.	6.17	.	T	D	B	N	D	N	.	.	0.203	T	T	D	0.066	0.201	0.129	.	D	T	T	T	D	T	2.588	22.600	0.998	D	N	0.099	2.883	0.166	3.021	1.000	0.437	0.552	0.607	0.555	.	3.790	3.790	2.852	1.172	0.674	0.503	1.000	0.999	759	.	.	.	.	PDE4A	392	0	347	60	0.147420147420147	TRUE	TRUE
ENSG00000105613.10	.	BCM	GRCh38.p13	chr19	12873723	12873723	+	G	G	A	Missense_Mutation	SNP	ENST00000251472.9	exon26	c.G3566A	p.R1189H	exonic	ENSG00000105613.10	.	nonsynonymous SNV	ENSG00000105613.10:ENST00000251472.9:exon26:c.G3566A:p.R1189H	19p13.13	C3N-03086	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	D	D	M	T	D	0.384	T	T	D	0.282	0.183	0.807	.	D	T	T	T	D	D	4.632	32	0.999	D	D	0.799	8.758	0.770	9.288	1.000	0.718	0.694	0.571	0.555	.	4.800	4.800	9.832	1.079	0.674	1.000	0.998	0.997	587	.	.	.	.	MAST1	326	1	277	36	0.115015974440895	TRUE	TRUE
ENSG00000039650.12	.	BCM	GRCh38.p13	chr19	49865323	49865323	+	G	G	A	Missense_Mutation	SNP	ENST00000322344.8	exon4	c.C302T	p.P101L	exonic	ENSG00000039650.12	.	nonsynonymous SNV	ENSG00000039650.12:ENST00000322344.8:exon4:c.C302T:p.P101L	19q13.33	C3N-03086	.	.	.	.	.	.	.	.	rs587784367	11.20	D	D	D	P	D	D	M	T	D	0.760	T	T	T	0.171	0.692	0.393	0.127	T	T	T	T	D	D	4.035	27.200	0.998	D	D	0.525	5.237	0.533	5.476	1.000	0.722	0.672	0.696	0.735	.	4.660	4.660	6.015	1.176	0.676	1.000	0.958	0.983	594	.	.	.	ID=COSV55586028;OCCURENCE=1(large_intestine)	PNKP	644	1	508	77	0.131623931623932	TRUE	TRUE
ENSG00000157554.19	.	BCM	GRCh38.p13	chr21	38403635	38403635	+	C	C	T	Missense_Mutation	SNP	ENST00000288319.12	exon4	c.G463A	p.V155I	exonic	ENSG00000157554.19	.	nonsynonymous SNV	ENSG00000157554.19:ENST00000288319.12:exon4:c.G463A:p.V155I	21q22.2	C3N-03086	4.119e-05	0	0	0.0001	0	5.994e-05	0	0	rs552037654	5.20	T	T	P	B	D	D	N	T	N	0.195	T	T	T	0.098	.	0.322	0.919	T	T	T	T	T	D	1.816	17.850	0.496	D	D	-0.113	2.134	0.035	2.482	1.000	0.672	0.590	0.602	0.711	.	5.600	5.600	4.723	1.026	0.599	1.000	0.139	0.867	922	Pointed_domain	.	.	ID=COSV55726607;OCCURENCE=5(large_intestine),2(stomach),1(kidney),1(thyroid)	ERG	515	1	510	45	0.0810810810810811	TRUE	TRUE
ENSG00000142156.15	.	BCM	GRCh38.p13	chr21	46002321	46002321	+	G	G	A	Missense_Mutation	SNP	ENST00000361866.8	exon32	c.G2170A	p.A724T	exonic	ENSG00000142156.15	.	nonsynonymous SNV	ENSG00000142156.15:ENST00000361866.8:exon32:c.G2170A:p.A724T	21q22.3	C3N-03086	.	.	.	.	.	.	.	.	rs986553501	17.20	D	D	D	P	D	D	M	D	D	0.808	D	D	D	0.657	0.549	0.895	0.770	T	D	D	D	D	T	3.954	26.700	0.998	D	D	0.405	4.371	0.320	3.835	1.000	0.696	0.588	0.723	0.563	.	4.970	4.970	9.273	1.109	0.676	1.000	0.043	0.023	976	von_Willebrand_factor,_type_A	.	.	ID=COSV62612515;OCCURENCE=2(stomach)	COL6A1	416	0	289	43	0.129518072289157	TRUE	NA
ENSG00000184571.13	.	BCM	GRCh38.p13	chr22	24754122	24754122	+	C	C	T	Missense_Mutation	SNP	ENST00000332271.9	exon8	c.G869A	p.R290Q	exonic	ENSG00000184571.13	.	nonsynonymous SNV	ENSG00000184571.13:ENST00000332271.9:exon8:c.G869A:p.R290Q	22q11.23	C3N-03086	2.471e-05	0	0	0	0	0	0	0.0002	rs748965457	8.20	D	D	D	D	U	N	M	T	D	0.662	T	T	T	0.083	0.550	0.444	0.187	T	T	T	T	D	D	2.793	23.000	0.999	N	N	-0.038	2.379	-0.321	1.522	1.000	0.487	0.574	0.547	0.527	.	2.420	0.293	1.612	-0.632	-0.377	0.929	0.013	0.007	483	.	.	.	ID=COSV59994067;OCCURENCE=1(large_intestine)	PIWIL3	300	0	190	24	0.11214953271028	TRUE	TRUE
ENSG00000197976.12	.	BCM	GRCh38.p13	chrX	1601466	1601466	+	A	A	G	Missense_Mutation	SNP	ENST00000313871.9	exon5	c.A1960G	p.R654G	exonic	ENSG00000197976.12	.	nonsynonymous SNV	ENSG00000197976.12:ENST00000313871.9:exon5:c.A1960G:p.R654G	Xp22.33	C3N-03086	.	.	.	.	.	.	.	.	.	5.19	D	D	D	P	U	N	L	T	N	0.112	T	T	D	0.083	0.212	0.316	0.077	T	T	T	T	D	T	1.610	16.440	0.754	N	.	.	.	.	.	0.992	.	.	.	.	.	0.860	0.860	1.333	0.775	0.557	0.024	0.077	0.140	1000	.	.	.	.	AKAP17A	81	1	56	4	0.0666666666666667	TRUE	NA
ENSG00000169933.15	.	BCM	GRCh38.p13	chrX	12609830	12609830	+	G	G	T	Missense_Mutation	SNP	ENST00000380682.5	exon3	c.G268T	p.G90C	exonic	ENSG00000169933.15	.	nonsynonymous SNV	ENSG00000169933.15:ENST00000380682.5:exon3:c.G268T:p.G90C	Xp22.2	C3N-03086	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	H	T	D	0.966	D	T	D	0.694	0.438	0.943	2.089	D	T	D	D	D	D	4.224	28.900	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.010	5.010	9.372	1.176	0.676	1.000	0.999	0.998	912	PDZ_domain	.	.	.	FRMPD4	104	0	79	15	0.159574468085106	TRUE	TRUE
ENSG00000144550.13	.	BCM	GRCh38.p13	chr3	9712829	9712829	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000144550.13	ENST00000383832.8:exon9:c.545+1G>A	.	.	3p25.3	C3N-03086	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.867	35	0.996	D	.	1.228	26.513	1.076	24.550	1.000	0.075	0.110	0.084	0.075	0.985	5.150	5.150	9.957	1.176	0.676	1.000	1.000	0.999	694	.	.	.	.	CPNE9	120	0	71	31	0.303921568627451	TRUE	NA
ENSG00000114331.15	.	BCM	GRCh38.p13	chr3	195306592	195306592	+	G	G	A	Silent	SNP	ENST00000326793.11	exon13	c.C1035T	p.S345S	exonic	ENSG00000114331.15	.	synonymous SNV	ENSG00000114331.15:ENST00000326793.11:exon13:c.C1035T:p.S345S	3q29	C3N-03086	1.648e-05	0	0	0.0002	0	0	0	0	rs754957296	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACAP2	201	0	182	18	0.09	TRUE	NA
ENSG00000153404.14	.	BCM	GRCh38.p13	chr5	154943	154943	+	C	C	T	Silent	SNP	ENST00000283426.11	exon6	c.C993T	p.L331L	exonic	ENSG00000153404.14	.	synonymous SNV	ENSG00000153404.14:ENST00000283426.11:exon6:c.C993T:p.L331L	5p15.33	C3N-03086	2.472e-05	0	0.0002	0	0	0	0	6.056e-05	rs141380436	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52046488;OCCURENCE=1(skin)	PLEKHG4B	307	1	265	29	0.0986394557823129	TRUE	TRUE
ENSG00000151746.15	.	BCM	GRCh38.p13	chr12	32338909	32338909	+	C	C	T	Silent	SNP	ENST00000652176.1	exon8	c.C2694T	p.P898P	exonic	ENSG00000151746.15	.	synonymous SNV	ENSG00000151746.15:ENST00000652176.1:exon8:c.C2694T:p.P898P	12p11.21	C3N-03086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BICD1	293	0	184	36	0.163636363636364	TRUE	TRUE
ENSG00000184047.19	.	BCM	GRCh38.p13	chr12	122224554	122224554	+	C	C	T	Silent	SNP	ENST00000464942.7	exon2	c.G141A	p.T47T	exonic	ENSG00000184047.19;ENSG00000284934.1	.	synonymous SNV	ENSG00000184047.19:ENST00000464942.7:exon2:c.G141A:p.T47T,ENSG00000284934.1:ENST00000443649.8:exon3:c.G141A:p.T47T	12q24.31	C3N-03086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DIABLO	576	0	444	71	0.137864077669903	TRUE	NA
ENSG00000121053.6	.	BCM	GRCh38.p13	chr17	58197046	58197046	+	C	C	T	Silent	SNP	ENST00000225371.6	exon7	c.C909T	p.N303N	exonic	ENSG00000121053.6	.	synonymous SNV	ENSG00000121053.6:ENST00000225371.6:exon7:c.C909T:p.N303N	17q22	C3N-03086	0.0008	9.61e-05	0.0038	0.0061	0	2.997e-05	0	0	rs138295034	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56599761;OCCURENCE=1(adrenal_gland),1(stomach)	EPX	440	0	390	46	0.105504587155963	TRUE	TRUE
ENSG00000078699.22	.	BCM	GRCh38.p13	chr20	33623123	33623123	+	G	G	A	Silent	SNP	ENST00000346541.7	exon6	c.G546A	p.L182L	exonic	ENSG00000078699.22	.	synonymous SNV	ENSG00000078699.22:ENST00000346541.7:exon6:c.G546A:p.L182L	20q11.22	C3N-03086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CBFA2T2	197	0	175	30	0.146341463414634	TRUE	TRUE
ENSG00000108557.19	.	BCM	GRCh38.p13	chr17	17810876	17810876	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000108557.19	ENST00000353383.6:c.*895G>A	.	.	17p11.2	C3N-03086	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAI1	116	0	71	12	0.144578313253012	TRUE	NA
ENSG00000161692.18	.	BCM	GRCh38.p13	chr17	44749426	44749426	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000161692.18	.	.	.	17q21.31	C3N-03086	.	.	.	.	.	.	.	.	rs566628181	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DBF4B	205	0	208	23	0.0995670995670996	TRUE	NA
ENSG00000127603.29	.	BCM	GRCh38.p13	chr1	39250090	39250090	+	C	C	T	Missense_Mutation	SNP	ENST00000372915.7	exon3	c.C359T	p.S120L	exonic	ENSG00000127603.29	.	nonsynonymous SNV	ENSG00000127603.29:ENST00000372915.7:exon3:c.C359T:p.S120L	1p34.3	C3L-02463	.	.	.	.	.	.	.	.	.	16.16	D	D	.	.	.	D	.	D	D	0.871	D	D	D	0.910	0.610	0.909	.	D	D	D	D	D	D	3.706	25.400	0.999	D	D	0.654	6.520	0.696	7.676	1.000	0.732	0.725	0.744	0.711	.	5.560	5.560	7.840	1.026	0.549	1.000	0.973	0.985	823	Calponin_homology_domain	.	.	.	MACF1	264	0	203	43	0.17479674796748	TRUE	TRUE
ENSG00000162624.14	.	BCM	GRCh38.p13	chr1	75156917	75156917	+	C	C	T	Missense_Mutation	SNP	ENST00000294638.9	exon9	c.C835T	p.R279C	exonic	ENSG00000162624.14	.	nonsynonymous SNV	ENSG00000162624.14:ENST00000294638.9:exon9:c.C835T:p.R279C	1p31.1	C3L-02463	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.840	D	D	D	0.938	0.793	0.938	1.274	D	D	D	D	D	D	4.212	28.800	0.999	D	D	0.822	9.227	0.741	8.592	1.000	0.554	0.574	0.618	0.542	.	5.020	5.020	4.626	1.026	0.599	1.000	1.000	1.000	843	Homeobox,_conserved_site;Homeobox_domain	.	.	ID=COSV53955118;OCCURENCE=1(breast),1(large_intestine),1(bone),1(prostate)	LHX8	648	0	469	123	0.20777027027027	TRUE	TRUE
ENSG00000197915.7	.	BCM	GRCh38.p13	chr1	152220448	152220448	+	G	G	A	Missense_Mutation	SNP	ENST00000368801.4	exon3	c.C1181T	p.S394L	exonic	ENSG00000197915.7	.	nonsynonymous SNV	ENSG00000197915.7:ENST00000368801.4:exon3:c.C1181T:p.S394L	1q21.3	C3L-02463	.	.	.	.	.	.	.	.	.	3.19	T	D	B	B	.	N	M	T	D	0.163	T	T	T	0.019	0.424	0.353	.	T	T	T	T	T	T	0.511	6.618	0.645	N	N	-0.983	0.423	-1.031	0.451	0.000	0.487	0.547	0.574	0.564	.	3.480	1.540	-0.036	0.157	0.563	0.000	0.002	0.005	570	.	.	.	.	HRNR	448	0	315	72	0.186046511627907	TRUE	NA
ENSG00000163468.15	.	BCM	GRCh38.p13	chr1	156312042	156312042	+	G	G	A	Missense_Mutation	SNP	ENST00000295688.8	exon11	c.C1154T	p.S385L	exonic	ENSG00000163468.15	.	nonsynonymous SNV	ENSG00000163468.15:ENST00000295688.8:exon11:c.C1154T:p.S385L	1q22	C3L-02463	2.504e-05	0.0002	0	0	0	0	0	6.373e-05	rs368091711	9.20	T	T	B	B	D	D	L	T	D	0.377	T	T	D	0.374	.	0.468	0.240	T	D	T	T	D	D	3.387	24.400	0.997	D	D	0.029	2.615	0.221	3.289	1.000	0.707	0.725	0.702	0.714	.	5.820	4.910	8.017	1.176	0.665	1.000	0.994	0.950	308	.	.	.	.	CCT3	152	0	105	28	0.210526315789474	TRUE	NA
ENSG00000018625.15	.	BCM	GRCh38.p13	chr1	160139972	160139972	+	C	C	T	Missense_Mutation	SNP	ENST00000361216.8	exon22	c.C3022T	p.R1008W	exonic	ENSG00000018625.15	.	nonsynonymous SNV	ENSG00000018625.15:ENST00000361216.8:exon22:c.C3022T:p.R1008W	1q23.2	C3L-02463	.	.	.	.	.	.	.	.	.	19.20	D	D	D	P	D	D	H	D	D	0.879	D	D	D	0.800	0.519	0.954	2.400	D	D	D	D	D	D	4.131	28.000	0.999	D	D	0.485	4.922	0.346	3.995	0.976	0.707	0.590	0.725	0.542	.	4.370	2.400	1.606	1.026	0.599	0.800	0.998	0.988	840	.	.	.	ID=COSV63401929;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),2(pancreas),1(lung),1(endometrium)	ATP1A2	747	0	555	105	0.159090909090909	TRUE	TRUE
ENSG00000144057.15	.	BCM	GRCh38.p13	chr2	106843743	106843743	+	C	C	T	Missense_Mutation	SNP	ENST00000409382.7	exon2	c.G235A	p.A79T	exonic	ENSG00000144057.15	.	nonsynonymous SNV	ENSG00000144057.15:ENST00000409382.7:exon2:c.G235A:p.A79T	2q12.3	C3L-02463	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.024	T	T	T	0.045	0.072	0.040	0.473	T	T	T	T	T	T	0.395	5.377	0.619	N	N	-1.127	0.283	-1.086	0.390	0.074	0.646	0.574	0.645	0.564	.	5.180	2.360	0.605	-0.236	-0.187	0.000	0.000	0.004	872	.	.	.	.	ST6GAL2	191	0	155	38	0.196891191709845	TRUE	TRUE
ENSG00000054219.11	.	BCM	GRCh38.p13	chr2	159808542	159808542	+	C	C	T	Missense_Mutation	SNP	ENST00000263636.5	exon33	c.G4729A	p.D1577N	exonic	ENSG00000054219.11;ENSG00000248672.5	.	nonsynonymous SNV	ENSG00000054219.11:ENST00000263636.5:exon33:c.G4729A:p.D1577N,ENSG00000248672.5:ENST00000504764.5:exon33:c.G4729A:p.D1577N	2q24.2	C3L-02463	.	.	.	.	.	.	.	.	.	2.19	T	D	B	B	U	D	L	T	N	0.212	T	T	T	0.024	0.468	0.067	0.049	.	T	T	T	T	T	1.915	18.610	0.994	N	N	-0.515	1.147	-0.452	1.282	0.093	0.707	0.725	0.659	0.668	.	5.550	1.340	1.064	0.126	0.549	0.698	0.948	0.989	680	C-type_lectin-like	.	.	.	LY75	326	0	296	64	0.177777777777778	TRUE	TRUE
ENSG00000132394.11	.	BCM	GRCh38.p13	chr3	128153508	128153508	+	A	A	T	Translation_Start_Site	SNP	ENST00000254730.11	exon1	c.A1T	p.M1?	exonic	ENSG00000132394.11	.	startloss	ENSG00000132394.11:ENST00000254730.11:exon1:c.A1T:p.M1?	3q21.3	C3L-02463	.	.	.	.	.	.	.	.	rs1009397010	6.17	T	T	B	B	D	D	.	T	N	0.441	T	T	D	0.254	0.977	0.411	.	.	T	D	D	D	.	2.360	21.900	0.882	N	N	-0.337	1.524	-0.218	1.744	1.000	0.442	0.522	0.520	0.250	.	4.710	4.710	1.146	1.175	0.660	0.999	0.962	0.772	829	.	.	.	.	EEFSEC	395	0	286	66	0.1875	TRUE	NA
ENSG00000168769.13	.	BCM	GRCh38.p13	chr4	105234162	105234162	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000540549.5	exon3	c.221dupT	p.S75Efs*3	exonic	ENSG00000168769.13	.	frameshift insertion	ENSG00000168769.13:ENST00000540549.5:exon3:c.221dupT:p.S75Efs*3	4q24	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TET2	NA	NA	NA	NA	NA	NA	NA
ENSG00000137473.17	.	BCM	GRCh38.p13	chr4	146909148	146909148	+	G	G	A	Missense_Mutation	SNP	ENST00000325106.8	exon5	c.C278T	p.A93V	exonic	ENSG00000137473.17	.	nonsynonymous SNV	ENSG00000137473.17:ENST00000325106.8:exon5:c.C278T:p.A93V	4q31.22	C3L-02463	.	.	.	.	.	.	.	.	.	2.20	T	D	B	B	N	N	L	T	N	0.251	T	T	T	0.053	0.385	0.095	0.015	T	T	T	T	T	T	0.915	10.600	0.980	D	N	-0.630	0.933	-0.607	1.035	0.000	0.554	0.574	0.574	0.568	.	5.030	0.886	1.339	-0.226	-0.153	0.928	0.026	0.928	878	.	.	.	.	TTC29	596	0	530	111	0.173166926677067	TRUE	TRUE
ENSG00000164588.8	.	BCM	GRCh38.p13	chr5	45262366	45262366	+	G	G	A	Missense_Mutation	SNP	ENST00000303230.6	exon8	c.C2228T	p.P743L	exonic	ENSG00000164588.8	.	nonsynonymous SNV	ENSG00000164588.8:ENST00000303230.6:exon8:c.C2228T:p.P743L	5p12	C3L-02463	.	.	.	.	.	.	.	.	.	2.20	D	T	B	B	N	N	L	T	N	0.154	T	T	T	0.107	0.219	0.350	0.394	T	T	T	T	T	T	2.471	22.300	0.988	D	N	-0.435	1.308	-0.335	1.494	0.001	0.653	0.574	0.676	0.564	.	4.490	2.520	1.601	0.245	0.676	0.732	0.281	0.807	427	.	.	.	ID=COSV57502530;OCCURENCE=1(large_intestine),1(endometrium)	HCN1	212	1	139	37	0.210227272727273	TRUE	TRUE
ENSG00000113319.13	.	BCM	GRCh38.p13	chr5	80960817	80960817	+	G	G	A	Missense_Mutation	SNP	ENST00000265080.9	exon1	c.G79A	p.G27S	exonic	ENSG00000113319.13	.	nonsynonymous SNV	ENSG00000113319.13:ENST00000265080.9:exon1:c.G79A:p.G27S	5q14.1	C3L-02463	.	.	.	.	.	.	.	.	.	17.20	D	D	D	P	D	D	H	T	D	0.480	D	D	D	0.810	0.873	0.739	1.858	D	D	D	T	D	D	4.425	31	0.999	D	D	0.794	8.670	0.695	7.654	1.000	0.437	0.563	0.504	0.604	.	3.900	3.900	7.240	1.097	0.590	1.000	0.993	0.995	857	Pleckstrin_homology_domain	.	.	.	RASGRF2	182	0	188	44	0.189655172413793	TRUE	TRUE
ENSG00000145794.17	.	BCM	GRCh38.p13	chr5	127398760	127398760	+	C	C	-	Frame_Shift_Del	DEL	ENST00000503335.7	exon7	c.744delC	p.H248Qfs*88	exonic	ENSG00000145794.17	.	frameshift deletion	ENSG00000145794.17:ENST00000503335.7:exon7:c.744delC:p.H248Qfs*88	5q23.2	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MEGF10	422	0	299	53	0.150568181818182	TRUE	TRUE
ENSG00000158987.21	.	BCM	GRCh38.p13	chr5	131442380	131442380	+	C	C	G	Missense_Mutation	SNP	ENST00000509018.5	exon23	c.G3579C	p.R1193S	exonic	ENSG00000158987.21;ENSG00000273217.1	.	nonsynonymous SNV	ENSG00000158987.21:ENST00000509018.5:exon23:c.G3579C:p.R1193S,ENSG00000273217.1:ENST00000514667.1:exon24:c.G3729C:p.R1243S	5q31.1	C3L-02463	.	.	.	.	.	.	.	.	.	11.20	D	T	D	D	D	D	M	T	N	0.836	T	T	D	0.194	0.351	0.448	0.737	T	T	D	T	D	D	3.513	24.800	0.998	D	N	0.567	5.604	0.529	5.436	1.000	0.615	0.654	0.659	0.636	.	5.570	5.570	0.270	1.026	0.594	0.991	0.994	0.972	390	.	.	.	.	RAPGEF6	223	1	184	49	0.210300429184549	TRUE	TRUE
ENSG00000081818.4	.	BCM	GRCh38.p13	chr5	141123844	141123844	+	G	G	A	Missense_Mutation	SNP	ENST00000194152.4	exon1	c.G1846A	p.V616M	exonic	ENSG00000081818.4	.	nonsynonymous SNV	ENSG00000081818.4:ENST00000194152.4:exon1:c.G1846A:p.V616M	5q31.3	C3L-02463	.	.	.	.	.	.	.	.	.	7.19	D	D	D	P	.	N	M	T	D	0.467	T	T	T	0.296	0.678	0.419	.	T	T	T	T	D	D	3.206	23.900	0.998	N	N	0.301	3.786	0.203	3.197	0.001	0.490	0.574	0.668	0.564	.	4.120	4.120	2.009	1.097	0.342	0.891	0.033	0.065	523	Cadherin-like	.	.	ID=COSV52024048;OCCURENCE=1(central_nervous_system)	PCDHB4	1638	0	1096	254	0.188148148148148	NA	TRUE
ENSG00000146457.16	.	BCM	GRCh38.p13	chr6	159753473	159753473	+	A	A	G	Missense_Mutation	SNP	ENST00000621533.5	exon7	c.A466G	p.K156E	exonic	ENSG00000146457.16	.	nonsynonymous SNV	ENSG00000146457.16:ENST00000621533.5:exon7:c.A466G:p.K156E	6q25.3	C3L-02463	.	.	.	.	.	.	.	.	.	11.20	D	D	P	B	D	D	L	T	N	0.872	T	T	D	0.355	0.228	0.543	1.707	D	T	D	D	D	T	3.082	23.600	0.996	D	D	0.419	4.465	0.483	5.004	1.000	0.672	0.702	0.702	0.711	.	5.870	4.710	9.299	1.312	0.756	1.000	1.000	1.000	821	.	.	.	ID=COSV61610182;OCCURENCE=1(pancreas)	WTAP	433	0	319	92	0.223844282238443	TRUE	TRUE
ENSG00000127955.17	.	BCM	GRCh38.p13	chr7	80203747	80203747	+	C	C	T	Missense_Mutation	SNP	ENST00000649796.2	exon5	c.C505T	p.P169S	exonic	ENSG00000127955.17	.	nonsynonymous SNV	ENSG00000127955.17:ENST00000649796.2:exon5:c.C505T:p.P169S	7q21.11	C3L-02463	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.895	D	D	D	0.904	0.917	0.867	2.081	D	D	D	D	D	D	3.675	25.300	0.999	D	D	1.019	14.539	0.938	15.460	1.000	0.732	0.574	0.744	0.613	.	5.640	5.640	7.858	1.026	0.599	1.000	0.998	0.982	904	.	.	.	ID=COSV63522708;OCCURENCE=1(skin)	GNAI1	329	0	246	38	0.133802816901408	TRUE	TRUE
ENSG00000176623.12	.	BCM	GRCh38.p13	chr8	86477324	86477324	+	C	C	A	Missense_Mutation	SNP	ENST00000406452.8	exon8	c.G730T	p.A244S	exonic	ENSG00000176623.12	.	nonsynonymous SNV	ENSG00000176623.12:ENST00000406452.8:exon8:c.G730T:p.A244S	8q21.3	C3L-02463	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.744	D	D	D	0.503	0.734	0.867	0.344	T	T	D	D	D	D	4.945	33	0.998	D	D	0.884	10.646	0.840	11.402	1.000	0.732	0.744	0.710	0.728	.	5.510	5.510	5.987	0.997	0.599	1.000	1.000	0.996	703	.	.	.	.	RMDN1	173	0	154	29	0.158469945355191	TRUE	TRUE
ENSG00000189376.12	.	BCM	GRCh38.p13	chr8	123226628	123226628	+	G	G	T	Missense_Mutation	SNP	ENST00000276704.6	exon5	c.C820A	p.L274M	exonic	ENSG00000189376.12;ENSG00000259305.6	.	nonsynonymous SNV	ENSG00000189376.12:ENST00000276704.6:exon5:c.C820A:p.L274M,ENSG00000259305.6:ENST00000357082.8:exon5:c.C724A:p.L242M	8q24.13	C3L-02463	.	.	.	.	.	.	.	.	.	11.18	D	D	D	D	D	D	M	.	N	0.633	T	T	T	0.339	0.629	0.324	0.341	.	T	D	D	D	T	2.433	22.200	0.992	D	N	-0.007	2.486	-0.124	1.980	1.000	0.732	0.725	0.744	0.714	.	5.710	0.494	0.133	-0.068	-0.116	0.829	0.996	0.976	974	.	.	.	.	C8orf76	211	0	132	33	0.2	TRUE	TRUE
ENSG00000160949.17	.	BCM	GRCh38.p13	chr8	144437072	144437072	+	A	A	G	Missense_Mutation	SNP	ENST00000409379.8	exon14	c.T1681C	p.C561R	exonic	ENSG00000160949.17	.	nonsynonymous SNV	ENSG00000160949.17:ENST00000409379.8:exon14:c.T1681C:p.C561R	8q24.3	C3L-02463	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	N	T	D	0.692	T	T	D	0.538	0.432	0.727	0.823	T	T	D	D	D	.	3.513	24.700	0.991	D	D	0.370	4.161	0.369	4.149	1.000	0.672	0.702	0.702	0.636	.	4.990	4.990	3.341	1.312	0.756	1.000	0.997	0.313	940	Ankyrin_repeat-containing_domain	.	.	.	TONSL	496	0	388	85	0.179704016913319	TRUE	TRUE
ENSG00000107731.12	.	BCM	GRCh38.p13	chr10	71284753	71284753	+	C	C	T	Missense_Mutation	SNP	ENST00000335350.10	exon3	c.C338T	p.S113L	exonic	ENSG00000107731.12	.	nonsynonymous SNV	ENSG00000107731.12:ENST00000335350.10:exon3:c.C338T:p.S113L	10q22.1	C3L-02463	2.477e-05	0	8.652e-05	0	0	1.503e-05	0	6.058e-05	rs779677077	13.20	D	D	D	D	D	D	M	T	D	0.521	T	T	D	0.319	0.494	0.685	0.140	T	T	T	T	D	D	3.774	25.700	0.999	D	D	0.525	5.236	0.413	4.450	1.000	0.696	0.547	0.723	0.563	.	4.750	3.840	6.157	1.010	0.580	1.000	0.796	0.777	884	Immunoglobulin_subtype	.	.	ID=COSV58976573;OCCURENCE=1(urinary_tract)	UNC5B	472	1	438	74	0.14453125	TRUE	TRUE
ENSG00000165841.11	.	BCM	GRCh38.p13	chr10	94820626	94820626	+	C	C	T	Missense_Mutation	SNP	ENST00000371321.9	exon6	c.C950T	p.P317L	exonic	ENSG00000165841.11	.	nonsynonymous SNV	ENSG00000165841.11:ENST00000371321.9:exon6:c.C950T:p.P317L	10q23.33	C3L-02463	.	.	.	.	.	.	.	.	.	6.15	D	D	.	.	U	D	.	T	D	0.540	T	T	T	0.272	0.875	0.685	0.023	T	.	T	T	D	.	2.818	23.100	0.998	D	N	0.522	5.212	0.372	4.166	0.000	0.487	0.574	0.574	0.564	.	3.950	3.950	2.158	0.990	0.527	0.986	0.377	0.057	517	.	.	.	.	CYP2C19	354	0	256	30	0.104895104895105	NA	TRUE
ENSG00000165887.12	.	BCM	GRCh38.p13	chr10	97577888	97577888	+	T	T	G	Missense_Mutation	SNP	ENST00000307518.9	exon2	c.T257G	p.L86R	exonic	ENSG00000165887.12	.	nonsynonymous SNV	ENSG00000165887.12:ENST00000307518.9:exon2:c.T257G:p.L86R	10q24.2	C3L-02463	.	.	.	.	.	.	.	.	.	5.20	D	T	P	P	N	N	M	T	N	0.711	T	T	D	0.256	0.438	0.771	0.758	T	T	D	T	D	T	2.704	22.800	0.948	N	N	-0.204	1.865	-0.314	1.535	1.000	0.517	0.563	0.479	0.563	.	4.650	4.650	2.841	1.138	0.665	0.035	0.005	0.006	372	.	.	.	.	ANKRD2	200	0	192	36	0.157894736842105	TRUE	TRUE
ENSG00000148704.13	.	BCM	GRCh38.p13	chr10	117134457	117134457	+	G	G	A	Missense_Mutation	SNP	ENST00000369206.6	exon3	c.C556T	p.R186C	exonic	ENSG00000148704.13	.	nonsynonymous SNV	ENSG00000148704.13:ENST00000369206.6:exon3:c.C556T:p.R186C	10q25.3	C3L-02463	8.718e-05	0	0	0	0	0	0	0.0001	rs778224173	20.20	D	D	D	D	D	D	M	D	D	0.244	D	D	D	0.722	0.338	0.878	2.320	D	D	D	D	D	D	4.278	29.400	0.999	D	D	0.519	5.189	0.471	4.904	1.000	0.598	0.590	0.378	0.639	.	4.450	4.450	2.706	0.988	0.501	1.000	0.992	0.824	704	.	.	.	.	VAX1	345	0	320	76	0.191919191919192	TRUE	NA
ENSG00000129083.12	.	BCM	GRCh38.p13	chr11	14481015	14481016	+	AG	AG	-	Frame_Shift_Del	DEL	ENST00000249923.7	exon9	c.1039_1040del	p.L347Cfs*4	exonic	ENSG00000129083.12	.	frameshift deletion	ENSG00000129083.12:ENST00000249923.7:exon9:c.1039_1040del:p.L347Cfs*4	11p15.2	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COPB1	350	0	268	47	0.149206349206349	TRUE	TRUE
ENSG00000086205.18	.	BCM	GRCh38.p13	chr11	49154366	49154366	+	C	C	T	Missense_Mutation	SNP	ENST00000256999.7	exon16	c.G1750A	p.V584M	exonic	ENSG00000086205.18	.	nonsynonymous SNV	ENSG00000086205.18:ENST00000256999.7:exon16:c.G1750A:p.V584M	11p11.12	C3L-02463	.	.	.	.	.	.	.	.	.	5.20	T	T	D	P	N	D	M	T	N	0.626	T	T	T	0.047	0.372	0.462	1.775	T	T	T	T	D	D	2.408	22.100	0.990	N	N	-0.108	2.148	-0.138	1.941	0.000	0.487	0.574	0.574	0.564	.	3.620	2.700	1.088	0.913	0.293	0.927	0.998	0.565	198	.	.	.	.	FOLH1	336	0	287	74	0.204986149584488	NA	TRUE
ENSG00000204381.11	.	BCM	GRCh38.p13	chr11	111540901	111540901	+	C	C	T	Missense_Mutation	SNP	ENST00000375615.7	exon1	c.C58T	p.R20W	exonic	ENSG00000204381.11	.	nonsynonymous SNV	ENSG00000204381.11:ENST00000375615.7:exon1:c.C58T:p.R20W	11q23.1	C3L-02463	.	.	.	.	.	.	.	.	.	6.20	D	D	D	P	N	N	M	T	N	0.229	T	T	D	0.100	0.535	0.331	0.085	T	T	T	T	D	T	1.341	14.680	0.997	N	N	-0.590	1.006	-0.800	0.757	1.000	0.685	0.541	0.674	0.555	.	4.440	0.128	-0.141	-0.374	-0.261	0.001	0.114	0.378	132	.	.	.	.	LAYN	417	0	487	103	0.174576271186441	TRUE	TRUE
ENSG00000111262.6	.	BCM	GRCh38.p13	chr12	4912512	4912512	+	G	G	T	Missense_Mutation	SNP	ENST00000382545.5	exon2	c.G1134T	p.M378I	exonic	ENSG00000111262.6	.	nonsynonymous SNV	ENSG00000111262.6:ENST00000382545.5:exon2:c.G1134T:p.M378I	12p13.32	C3L-02463	.	.	.	.	.	.	.	.	.	16.20	D	T	B	B	D	D	N	D	D	0.743	D	D	D	0.771	0.632	0.936	2.470	D	D	D	D	D	D	3.320	24.200	0.982	D	D	0.207	3.332	0.376	4.195	1.000	0.609	0.628	0.596	0.530	.	4.900	4.900	9.932	1.176	0.676	1.000	1.000	1.000	850	Ion_transport_domain	.	.	.	KCNA1	260	0	231	44	0.16	TRUE	TRUE
ENSG00000111732.11	.	BCM	GRCh38.p13	chr12	8605245	8605245	+	C	C	T	Missense_Mutation	SNP	ENST00000229335.11	exon3	c.G397A	p.G133R	exonic	ENSG00000111732.11	.	nonsynonymous SNV	ENSG00000111732.11:ENST00000229335.11:exon3:c.G397A:p.G133R	12p13.31	C3L-02463	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.838	D	D	D	0.609	0.818	0.875	2.076	T	T	D	D	D	D	3.300	24.100	0.998	D	D	0.516	5.163	0.403	4.380	1.000	0.672	0.702	0.576	0.542	.	5.560	5.560	7.345	1.008	0.599	1.000	0.341	0.088	927	APOBEC-like,_N-terminal	.	.	.	AICDA	811	0	581	144	0.198620689655172	TRUE	TRUE
ENSG00000197837.3	.	BCM	GRCh38.p13	chr12	14771053	14771053	+	A	A	G	Missense_Mutation	SNP	ENST00000539745.1	exon1	c.T32C	p.L11P	exonic	ENSG00000197837.3	.	nonsynonymous SNV	ENSG00000197837.3:ENST00000539745.1:exon1:c.T32C:p.L11P	12p12.3	C3L-02463	.	.	.	.	.	.	.	.	.	8.14	D	T	.	.	U	D	.	.	D	0.417	T	T	D	0.164	0.198	0.921	0.477	T	.	D	T	D	.	3.466	24.600	0.985	D	D	0.168	3.164	0.152	2.959	1.000	0.442	0.522	0.522	0.373	.	4.070	4.070	5.674	1.312	0.756	1.000	0.391	0.352	695	.	.	.	.	H4-16	146	0	146	29	0.165714285714286	TRUE	TRUE
ENSG00000134532.19	.	BCM	GRCh38.p13	chr12	23536655	23536655	+	C	C	G	Missense_Mutation	SNP	ENST00000451604.7	exon14	c.G1786C	p.A596P	exonic	ENSG00000134532.19	.	nonsynonymous SNV	ENSG00000134532.19:ENST00000451604.7:exon14:c.G1786C:p.A596P	12p12.1	C3L-02463	.	.	.	.	.	.	.	.	.	19.20	D	D	D	P	D	D	M	D	D	0.746	D	D	D	0.755	0.609	0.830	2.822	D	D	D	D	D	D	3.868	26.200	0.996	D	D	0.665	6.651	0.679	7.379	1.000	0.560	0.608	0.527	0.564	.	5.600	5.600	3.916	1.010	0.580	1.000	1.000	0.999	870	High_mobility_group_box_domain	.	.	.	SOX5	416	0	405	92	0.185110663983903	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-02463	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	461	2	396	101	0.203219315895372	TRUE	TRUE
ENSG00000129317.14	.	BCM	GRCh38.p13	chr12	43754611	43754611	+	T	T	A	Missense_Mutation	SNP	ENST00000344862.9	exon2	c.A635T	p.E212V	exonic	ENSG00000129317.14	.	nonsynonymous SNV	ENSG00000129317.14:ENST00000344862.9:exon2:c.A635T:p.E212V	12q12	C3L-02463	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	L	T	D	0.624	T	T	D	0.245	0.503	0.556	0.219	T	T	T	T	D	T	3.711	25.500	0.979	D	D	0.521	5.204	0.535	5.495	1.000	0.609	0.628	0.602	0.655	.	5.350	5.350	7.367	1.138	0.665	1.000	0.980	0.871	606	.	.	.	.	PUS7L	258	0	217	51	0.190298507462687	TRUE	TRUE
ENSG00000073910.22	.	BCM	GRCh38.p13	chr13	32239766	32239766	+	T	T	A	Missense_Mutation	SNP	ENST00000542859.6	exon46	c.T6572A	p.L2191H	exonic	ENSG00000073910.22	.	nonsynonymous SNV	ENSG00000073910.22:ENST00000542859.6:exon46:c.T6572A:p.L2191H	13q13.1	C3L-02463	.	.	.	.	.	.	.	.	.	13.17	.	D	D	D	D	D	M	.	.	0.954	T	T	T	0.517	0.540	0.278	1.400	D	T	D	D	D	D	4.219	28.800	0.982	D	D	0.847	9.762	0.837	11.308	1.000	0.651	0.574	0.659	0.684	.	6.070	6.070	8.017	1.138	0.665	1.000	0.998	0.995	946	Cell_morphogenesis_protein_C-terminal	.	.	.	FRY	410	0	343	71	0.171497584541063	TRUE	TRUE
ENSG00000139797.8	.	BCM	GRCh38.p13	chr13	98176839	98176839	+	C	C	T	Missense_Mutation	SNP	ENST00000267291.7	exon1	c.G398A	p.R133Q	exonic	ENSG00000139797.8	.	nonsynonymous SNV	ENSG00000139797.8:ENST00000267291.7:exon1:c.G398A:p.R133Q	13q32.2	C3L-02463	0.0001	0.0013	8.64e-05	0	0	0	0	0	rs116650511	1.20	T	T	B	B	U	D	N	T	N	0.058	T	T	T	0.060	.	0.199	0.543	T	T	T	T	T	T	0.820	9.593	0.883	N	N	-1.203	0.225	-1.248	0.245	1.000	0.487	0.574	0.578	0.714	.	1.160	-1.660	1.601	-0.439	-0.315	1.000	0.004	0.001	689	.	.	.	.	RNF113B	436	0	316	92	0.225490196078431	TRUE	NA
ENSG00000156218.13	.	BCM	GRCh38.p13	chr15	83942964	83942964	+	C	C	T	Missense_Mutation	SNP	ENST00000286744.10	exon19	c.C2372T	p.T791M	exonic	ENSG00000156218.13	.	nonsynonymous SNV	ENSG00000156218.13:ENST00000286744.10:exon19:c.C2372T:p.T791M	15q25.2	C3L-02463	3.319e-05	9.61e-05	0	0	0	4.517e-05	0	0	rs144077662	3.20	T	T	D	P	N	D	L	T	N	0.369	T	T	T	0.086	.	0.691	0.439	T	T	T	T	T	T	2.851	23.100	0.997	D	N	0.099	2.881	0.084	2.672	0.206	0.554	0.588	0.618	0.564	.	5.190	4.280	4.741	1.026	0.599	1.000	0.973	0.987	350	.	.	.	ID=COSV54450723;OCCURENCE=2(large_intestine),1(lung)	ADAMTSL3	279	0	242	52	0.17687074829932	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673802	7673802	+	C	C	A	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G818T	p.R273L	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G818T:p.R273L	17p13.1	C3L-02463	8.761e-06	0	0	0	0	1.582e-05	0	0	rs28934576	19.20	D	D	D	D	D	D	M	D	D	0.974	D	D	D	0.921	0.988	0.997	0.422	T	D	D	D	D	D	4.141	28.100	0.998	D	D	0.679	6.833	0.537	5.513	1.000	0.722	0.702	0.725	0.735	.	4.920	4.920	7.905	1.022	0.596	1.000	0.856	0.980	432	p53,_DNA-binding_domain	.	.	ID=COSV52664805;OCCURENCE=2(salivary_gland),15(breast),7(liver),12(oesophagus),9(large_intestine),6(central_nervous_system),1(biliary_tract),1(pleura),8(ovary),1(bone),2(NS),3(stomach),4(haematopoietic_and_lymphoid_tissue),1(kidney),10(urinary_tract),3(pancreas),3(skin),4(prostate),126(lung),2(thyroid),9(upper_aerodigestive_tract),1(testis),2(endometrium)	TP53	1028	1	665	189	0.221311475409836	TRUE	TRUE
ENSG00000198720.13	.	BCM	GRCh38.p13	chr17	29611984	29611984	+	G	G	A	Missense_Mutation	SNP	ENST00000394859.8	exon10	c.G1078A	p.E360K	exonic	ENSG00000198720.13	.	nonsynonymous SNV	ENSG00000198720.13:ENST00000394859.8:exon10:c.G1078A:p.E360K	17q11.2	C3L-02463	.	.	.	.	.	.	.	.	.	10.20	D	D	P	P	D	D	L	T	D	0.307	T	T	T	0.229	0.408	0.586	1.314	D	T	T	T	D	D	3.994	26.900	0.999	D	D	0.597	5.888	0.642	6.787	0.999	0.732	0.634	0.723	0.728	.	5.970	5.970	4.296	1.176	0.676	1.000	1.000	0.996	82	.	.	.	.	ANKRD13B	169	0	150	30	0.166666666666667	TRUE	TRUE
ENSG00000198720.13	.	BCM	GRCh38.p13	chr17	29612186	29612186	+	G	G	A	Missense_Mutation	SNP	ENST00000394859.8	exon11	c.G1171A	p.D391N	exonic	ENSG00000198720.13	.	nonsynonymous SNV	ENSG00000198720.13:ENST00000394859.8:exon11:c.G1171A:p.D391N	17q11.2	C3L-02463	.	.	.	.	.	.	.	.	.	12.20	D	D	P	P	D	D	M	T	D	0.669	T	T	D	0.506	0.477	0.808	1.867	D	T	T	T	D	D	4.232	29.000	0.999	D	D	0.784	8.467	0.803	10.200	1.000	0.635	0.634	0.723	0.646	.	5.830	5.830	8.119	1.176	0.676	1.000	1.000	0.998	82	.	.	.	ID=COSV61470366;OCCURENCE=1(large_intestine)	ANKRD13B	317	0	302	63	0.172602739726027	TRUE	TRUE
ENSG00000120071.14	.	BCM	GRCh38.p13	chr17	46034246	46034246	+	C	C	G	Missense_Mutation	SNP	ENST00000432791.6	exon11	c.G2581C	p.D861H	exonic	ENSG00000120071.14	.	nonsynonymous SNV	ENSG00000120071.14:ENST00000432791.6:exon11:c.G2581C:p.D861H	17q21.31	C3L-02463	.	.	.	.	.	.	.	.	.	13.16	D	D	.	.	D	D	.	T	D	0.907	T	T	D	0.454	0.301	0.797	1.438	D	.	D	D	D	D	3.929	26.500	0.995	D	D	0.709	7.243	0.655	6.980	1.000	0.707	0.725	0.702	0.714	.	5.590	5.590	7.813	1.026	0.599	1.000	0.745	0.851	406	.	.	.	.	KANSL1	515	2	496	71	0.125220458553792	TRUE	TRUE
ENSG00000108375.12	.	BCM	GRCh38.p13	chr17	58358406	58358406	+	T	T	-	Frame_Shift_Del	DEL	ENST00000584437.5	exon8	c.1370delA	p.Y457Sfs*45	exonic	ENSG00000108375.12;ENSG00000285897.1	.	frameshift deletion	ENSG00000108375.12:ENST00000584437.5:exon8:c.1370delA:p.Y457Sfs*45,ENSG00000285897.1:ENST00000648873.1:exon8:c.1370delA:p.Y457Sfs*45	17q22	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF43	234	0	141	43	0.233695652173913	TRUE	TRUE
ENSG00000141431.12	.	BCM	GRCh38.p13	chr18	33670776	33670776	+	C	C	T	Missense_Mutation	SNP	ENST00000269197.12	exon6	c.C581T	p.S194L	exonic	ENSG00000141431.12	.	nonsynonymous SNV	ENSG00000141431.12:ENST00000269197.12:exon6:c.C581T:p.S194L	18q12.1	C3L-02463	.	.	.	.	.	.	.	.	rs931090804	9.19	D	T	D	D	.	D	N	T	N	0.728	T	T	T	0.141	0.218	0.082	0.497	D	T	T	T	D	D	3.898	26.300	0.999	D	D	0.576	5.689	0.618	6.459	1.000	0.487	0.574	0.547	0.564	.	5.480	5.480	5.752	1.026	0.599	1.000	1.000	0.997	711	.	.	.	.	ASXL3	166	0	131	29	0.18125	TRUE	NA
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51048789	51048789	+	C	C	T	Missense_Mutation	SNP	ENST00000342988.8	exon3	c.C353T	p.A118V	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon3:c.C353T:p.A118V	18q21.2	C3L-02463	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.721	D	D	D	0.873	0.759	0.890	2.751	D	D	D	D	D	D	3.914	26.400	0.999	D	D	0.896	10.959	0.841	11.447	1.000	0.707	0.725	0.663	0.714	.	5.480	5.480	7.902	1.026	0.549	1.000	0.722	0.800	680	MAD_homology_1,_Dwarfin-type;MAD_homology,_MH1	.	.	ID=COSV61684095;OCCURENCE=3(breast),2(oesophagus),23(large_intestine),1(bone),1(stomach),9(pancreas),1(upper_aerodigestive_tract)	SMAD4	565	1	351	114	0.245161290322581	TRUE	TRUE
ENSG00000256463.8	.	BCM	GRCh38.p13	chr18	78997209	78997209	+	C	C	T	Missense_Mutation	SNP	ENST00000537592.6	exon3	c.C3790T	p.R1264C	exonic	ENSG00000256463.8	.	nonsynonymous SNV	ENSG00000256463.8:ENST00000537592.6:exon3:c.C3790T:p.R1264C	18q23	C3L-02463	3.301e-05	0	8.645e-05	0	0	1.503e-05	0	0.0001	rs146109999	10.20	D	D	B	B	D	D	M	T	D	0.394	T	T	D	0.133	.	0.644	0.558	T	T	T	T	D	D	1.724	17.190	0.606	D	N	-0.150	2.023	-0.186	1.819	1.000	0.632	0.574	0.698	0.613	.	5.320	4.450	2.569	0.126	0.599	0.979	0.002	0.001	.	.	.	.	ID=COSV73305976;OCCURENCE=2(endometrium)	SALL3	508	0	260	76	0.226190476190476	TRUE	TRUE
ENSG00000196350.9	.	BCM	GRCh38.p13	chr19	22315441	22315441	+	A	A	C	Missense_Mutation	SNP	ENST00000601693.2	exon4	c.A2024C	p.K675T	exonic	ENSG00000196350.9	.	nonsynonymous SNV	ENSG00000196350.9:ENST00000601693.2:exon4:c.A2024C:p.K675T	19p12	C3L-02463	.	.	.	.	.	.	.	.	.	2.14	.	D	.	.	.	.	L	T	.	0.284	T	T	T	0.031	-	0.092	0.011	T	T	T	T	T	D	1.080	12.560	0.994	N	N	-0.792	0.666	-0.972	0.525	0.000	0.487	0.574	0.574	0.564	.	0.996	0.996	-0.138	0.530	0.323	0.000	0.001	0.001	988	Zinc_finger_C2H2-type	.	.	.	ZNF729	395	0	426	91	0.176015473887814	NA	TRUE
ENSG00000196381.11	.	BCM	GRCh38.p13	chr19	37670070	37670070	+	G	G	A	Missense_Mutation	SNP	ENST00000358582.9	exon4	c.C79T	p.H27Y	exonic	ENSG00000196381.11	.	nonsynonymous SNV	ENSG00000196381.11:ENST00000358582.9:exon4:c.C79T:p.H27Y	19q13.12	C3L-02463	.	.	.	.	.	.	.	.	.	6.15	D	D	.	.	.	D	M	T	D	0.217	T	T	T	0.172	0.716	0.030	0.088	.	.	T	T	D	T	1.536	15.970	0.992	N	N	-0.001	2.508	-0.228	1.721	0.952	0.554	0.574	0.618	0.564	.	1.400	1.400	1.602	-0.154	0.503	0.956	0.000	0.003	662	.	.	.	.	ZNF781	142	0	128	45	0.260115606936416	TRUE	TRUE
ENSG00000090924.15	.	BCM	GRCh38.p13	chr19	39423534	39423534	+	G	G	A	Missense_Mutation	SNP	ENST00000425673.6	exon18	c.G2480A	p.R827Q	exonic	ENSG00000090924.15	.	nonsynonymous SNV	ENSG00000090924.15:ENST00000425673.6:exon18:c.G2480A:p.R827Q	19q13.2	C3L-02463	2.649e-05	0.0002	0.0001	0	0	0	0	0	rs374823888	11.20	D	D	D	D	D	D	M	T	N	0.513	T	T	D	0.252	.	0.786	.	T	T	T	T	D	D	3.837	26.000	0.999	D	N	0.535	5.323	0.531	5.456	1.000	0.707	0.702	0.702	0.714	.	5.790	4.760	1.907	1.176	0.676	1.000	0.871	0.849	679	.	.	.	.	PLEKHG2	66	0	60	19	0.240506329113924	TRUE	NA
ENSG00000124251.11	.	BCM	GRCh38.p13	chr20	45377610	45377610	+	G	G	A	Nonsense_Mutation	SNP	ENST00000372726.5	exon2	c.C52T	p.Q18X	exonic	ENSG00000124251.11	.	stopgain	ENSG00000124251.11:ENST00000372726.5:exon2:c.C52T:p.Q18X	20q13.12	C3L-02463	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	A	.	.	.	0.081	.	.	.	.	.	.	.	.	.	D	D	.	.	5.124	33	0.996	N	N	0.477	4.861	0.168	3.032	0.992	0.554	0.574	0.602	0.568	.	4.180	3.200	0.979	1.146	0.676	0.067	0.020	0.025	885	.	.	.	.	TP53TG5	445	0	360	78	0.178082191780822	TRUE	TRUE
ENSG00000211654.2	.	BCM	GRCh38.p13	chr22	22427901	22427901	+	C	C	T	Nonsense_Mutation	SNP	ENST00000390300.2	exon2	c.C235T	p.Q79X	exonic	ENSG00000211654.2	.	stopgain	ENSG00000211654.2:ENST00000390300.2:exon2:c.C235T:p.Q79X	22q11.22	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGLV5-37	711	0	619	62	0.0910425844346549	NA	TRUE
ENSG00000196576.15	.	BCM	GRCh38.p13	chr22	50282033	50282033	+	G	G	-	Frame_Shift_Del	DEL	ENST00000359337.9	exon20	c.3166delC	p.L1056Cfs*17	exonic	ENSG00000196576.15	.	frameshift deletion	ENSG00000196576.15:ENST00000359337.9:exon20:c.3166delC:p.L1056Cfs*17	22q13.33	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLXNB2	455	0	359	96	0.210989010989011	TRUE	TRUE
ENSG00000102362.15	.	BCM	GRCh38.p13	chrX	100686688	100686688	+	C	C	A	Missense_Mutation	SNP	ENST00000372989.5	exon14	c.G1278T	p.E426D	exonic	ENSG00000102362.15	.	nonsynonymous SNV	ENSG00000102362.15:ENST00000372989.5:exon14:c.G1278T:p.E426D	Xq22.1	C3L-02463	.	.	.	.	.	.	.	.	.	10.19	D	D	D	P	N	D	H	T	D	0.598	T	T	D	0.270	0.955	0.176	.	T	D	T	T	D	T	1.495	15.710	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.970	2.080	-0.068	0.103	0.599	0.262	0.552	0.596	65	C2_domain;Synaptotagmin-like_protein_4/5,_C2A_domain	.	.	.	SYTL4	108	0	83	44	0.346456692913386	TRUE	TRUE
ENSG00000178922.16	.	BCM	GRCh38.p13	chr1	43453457	43453457	+	G	G	A	Silent	SNP	ENST00000372425.8	exon2	c.C240T	p.P80P	exonic	ENSG00000178922.16	.	synonymous SNV	ENSG00000178922.16:ENST00000372425.8:exon2:c.C240T:p.P80P	1p34.2	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HYI	280	0	228	50	0.179856115107914	TRUE	TRUE
ENSG00000154358.21	.	BCM	GRCh38.p13	chr1	228295024	228295024	+	G	G	A	Silent	SNP	ENST00000422127.5	exon43	c.G11640A	p.S3880S	exonic	ENSG00000154358.21	.	synonymous SNV	ENSG00000154358.21:ENST00000422127.5:exon43:c.G11640A:p.S3880S	1q42.13	C3L-02463	4.967e-05	0	0.0003	0	0	1.498e-05	0	6.056e-05	rs549657012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OBSCN	525	0	392	130	0.24904214559387	TRUE	NA
ENSG00000072163.19	.	BCM	GRCh38.p13	chr2	127639395	127639395	+	C	C	T	Silent	SNP	ENST00000355119.8	exon10	c.G912A	p.V304V	exonic	ENSG00000072163.19	.	synonymous SNV	ENSG00000072163.19:ENST00000355119.8:exon10:c.G912A:p.V304V	2q14.3	C3L-02463	8.243e-06	0	0	0	0	0	0	6.058e-05	rs757061758	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LIMS2	322	0	229	53	0.187943262411348	TRUE	NA
ENSG00000054356.14	.	BCM	GRCh38.p13	chr2	219296316	219296316	+	G	G	A	Silent	SNP	ENST00000295718.7	exon18	c.C2418T	p.I806I	exonic	ENSG00000054356.14	.	synonymous SNV	ENSG00000054356.14:ENST00000295718.7:exon18:c.C2418T:p.I806I	2q35	C3L-02463	4.12e-05	0	0	0.0002	0	4.498e-05	0	0	rs761397429	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTPRN	409	0	347	71	0.169856459330144	TRUE	NA
ENSG00000168268.11	.	BCM	GRCh38.p13	chr3	52529258	52529258	+	G	G	A	Silent	SNP	ENST00000307076.8	exon2	c.C198T	p.D66D	exonic	ENSG00000168268.11	.	synonymous SNV	ENSG00000168268.11:ENST00000307076.8:exon2:c.C198T:p.D66D	3p21.1	C3L-02463	8.309e-06	0	0	0	0	1.516e-05	0	0	rs762216017	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58734597;OCCURENCE=1(prostate)	NT5DC2	615	0	502	97	0.161936560934891	TRUE	TRUE
ENSG00000186038.9	.	BCM	GRCh38.p13	chr3	184106324	184106324	+	C	C	T	Silent	SNP	ENST00000415389.6	exon8	c.C1122T	p.L374L	exonic	ENSG00000186038.9	.	synonymous SNV	ENSG00000186038.9:ENST00000415389.6:exon8:c.C1122T:p.L374L	3q27.1	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HTR3E	342	0	225	82	0.267100977198697	NA	TRUE
ENSG00000152611.12	.	BCM	GRCh38.p13	chr5	35904605	35904605	+	G	G	A	Silent	SNP	ENST00000651391.1	exon5	c.C567T	p.S189S	exonic	ENSG00000152611.12	.	synonymous SNV	ENSG00000152611.12:ENST00000651391.1:exon5:c.C567T:p.S189S	5p13.2	C3L-02463	6.608e-05	0	0	0.0003	0	7.511e-05	0	0	rs138016761	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV68437436;OCCURENCE=1(lung),1(endometrium)	CAPSL	357	0	294	46	0.135294117647059	TRUE	TRUE
ENSG00000176406.23	.	BCM	GRCh38.p13	chr8	103886111	103886111	+	C	C	T	Silent	SNP	ENST00000666250.1	exon4	c.C1512T	p.G504G	exonic	ENSG00000176406.23	.	synonymous SNV	ENSG00000176406.23:ENST00000666250.1:exon4:c.C1512T:p.G504G	8q22.3	C3L-02463	8.351e-06	0	0	0	0	1.511e-05	0	0	rs758569920	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51656297;OCCURENCE=1(breast),1(central_nervous_system),1(stomach),1(skin)	RIMS2	600	0	489	68	0.122082585278276	TRUE	TRUE
ENSG00000181790.11	.	BCM	GRCh38.p13	chr8	142481270	142481270	+	G	G	C	Silent	SNP	ENST00000517894.5	exon10	c.G1845C	p.R615R	exonic	ENSG00000181790.11	.	synonymous SNV	ENSG00000181790.11:ENST00000517894.5:exon10:c.G1845C:p.R615R	8q24.3	C3L-02463	3.32e-05	0	0	0	0	0	0	0.0002	rs754733336	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADGRB1	410	1	349	78	0.182669789227166	TRUE	NA
ENSG00000073921.18	.	BCM	GRCh38.p13	chr11	85981171	85981171	+	T	T	C	Silent	SNP	ENST00000393346.8	exon17	c.A1737G	p.Q579Q	exonic	ENSG00000073921.18	.	synonymous SNV	ENSG00000073921.18:ENST00000393346.8:exon17:c.A1737G:p.Q579Q	11q14.2	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PICALM	371	0	319	56	0.149333333333333	TRUE	TRUE
ENSG00000087299.12	.	BCM	GRCh38.p13	chr14	50267836	50267836	+	A	A	G	Silent	SNP	ENST00000267436.9	exon8	c.T981C	p.P327P	exonic	ENSG00000087299.12	.	synonymous SNV	ENSG00000087299.12:ENST00000267436.9:exon8:c.T981C:p.P327P	14q21.3	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	L2HGDH	408	0	338	85	0.200945626477541	TRUE	TRUE
ENSG00000129925.11	.	BCM	GRCh38.p13	chr16	374143	374143	+	G	G	A	Silent	SNP	ENST00000431232.7	exon11	c.C1764T	p.H588H	exonic	ENSG00000129925.11	.	synonymous SNV	ENSG00000129925.11:ENST00000431232.7:exon11:c.C1764T:p.H588H	16p13.3	C3L-02463	5.87e-05	0	0	0	0	3.065e-05	0	0.0003	rs377049744	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PGAP6	484	0	399	105	0.208333333333333	TRUE	NA
ENSG00000198720.13	.	BCM	GRCh38.p13	chr17	29611989	29611989	+	G	G	A	Silent	SNP	ENST00000394859.8	exon10	c.G1083A	p.L361L	exonic	ENSG00000198720.13	.	synonymous SNV	ENSG00000198720.13:ENST00000394859.8:exon10:c.G1083A:p.L361L	17q11.2	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANKRD13B	149	22	130	12	0.0845070422535211	TRUE	NA
ENSG00000198720.13	.	BCM	GRCh38.p13	chr17	29611998	29611998	+	G	G	A	Silent	SNP	ENST00000394859.8	exon10	c.G1092A	p.K364K	exonic	ENSG00000198720.13	.	synonymous SNV	ENSG00000198720.13:ENST00000394859.8:exon10:c.G1092A:p.K364K	17q11.2	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANKRD13B	136	0	117	9	0.0714285714285714	TRUE	TRUE
ENSG00000120071.14	.	BCM	GRCh38.p13	chr17	46034256	46034256	+	C	C	T	Silent	SNP	ENST00000432791.6	exon11	c.G2571A	p.E857E	exonic	ENSG00000120071.14	.	synonymous SNV	ENSG00000120071.14:ENST00000432791.6:exon11:c.G2571A:p.E857E	17q21.31	C3L-02463	8.24e-06	0	0	0	0	1.499e-05	0	0	rs760065547	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KANSL1	520	0	515	77	0.130067567567568	TRUE	NA
ENSG00000121064.13	.	BCM	GRCh38.p13	chr17	56997003	56997003	+	C	C	T	Silent	SNP	ENST00000262288.8	exon9	c.C828T	p.S276S	exonic	ENSG00000121064.13	.	synonymous SNV	ENSG00000121064.13:ENST00000262288.8:exon9:c.C828T:p.S276S	17q22	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCPEP1	182	0	95	17	0.151785714285714	TRUE	TRUE
ENSG00000198597.9	.	BCM	GRCh38.p13	chr19	30549078	30549078	+	G	G	A	Silent	SNP	ENST00000355537.4	exon4	c.G3459A	p.T1153T	exonic	ENSG00000198597.9	.	synonymous SNV	ENSG00000198597.9:ENST00000355537.4:exon4:c.G3459A:p.T1153T	19q12	C3L-02463	0.0002	0	0	0.0025	0	3.001e-05	0	0	rs199740602	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF536	493	0	338	82	0.195238095238095	TRUE	NA
ENSG00000254038.1	.	BCM	GRCh38.p13	chr8	37067622	37067622	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000254038.1	.	.	.	8p11.23	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC092818.1	276	1	240	68	0.220779220779221	TRUE	NA
ENSG00000143954.13	.	BCM	GRCh38.p13	chr2	79026102	79026103	+	TC	TC	AA	Unknown	MNP	ENST00000272324.10	exon2	c.9_10delinsAA	p.P4T	exonic	ENSG00000143954.13	.	nonframeshift substitution	ENSG00000143954.13:ENST00000272324.10:exon2:c.9_10delinsAA:p.P4T	2p12	C3L-02463	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	REG3G	427	0	289	58	0.167146974063401	NA	TRUE
ENSG00000033122.21	.	BCM	GRCh38.p13	chr1	70107753	70107753	+	G	G	T	Missense_Mutation	SNP	ENST00000651989.2	exon26	c.G4547T	p.G1516V	exonic	ENSG00000033122.21	.	nonsynonymous SNV	ENSG00000033122.21:ENST00000651989.2:exon26:c.G4547T:p.G1516V	1p31.1	C3N-00249	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.964	T	T	D	0.763	0.728	0.895	2.726	D	T	D	D	D	D	4.811	33	0.998	D	D	0.928	11.789	0.912	14.252	1.000	0.500	0.574	0.574	0.504	.	5.710	5.710	9.019	1.176	0.676	1.000	1.000	1.000	899	PDZ_domain	.	.	.	LRRC7	210	0	164	74	0.310924369747899	TRUE	TRUE
ENSG00000118257.16	.	BCM	GRCh38.p13	chr2	205743431	205743431	+	G	G	A	Missense_Mutation	SNP	ENST00000360409.7	exon9	c.G1520A	p.R507H	exonic	ENSG00000118257.16	.	nonsynonymous SNV	ENSG00000118257.16:ENST00000360409.7:exon9:c.G1520A:p.R507H	2q33.3	C3N-00249	0.0001	0	0	0	0	0	0	0.0008	rs537993529	17.20	D	D	D	D	D	D	L	D	D	0.677	D	D	D	0.636	0.655	0.987	0.928	T	D	T	D	D	D	4.179	28.500	0.999	D	D	0.590	5.825	0.559	5.745	1.000	0.707	0.588	0.725	0.714	.	5.960	5.960	7.573	1.106	0.676	1.000	0.959	0.927	802	Coagulation_factor_5/8_C-terminal_domain	.	.	ID=COSV55933480;OCCURENCE=1(oesophagus),1(large_intestine)	NRP2	447	0	577	181	0.238786279683377	TRUE	TRUE
ENSG00000144671.10	.	BCM	GRCh38.p13	chr3	38313096	38313096	+	A	A	C	Missense_Mutation	SNP	ENST00000273173.4	exon5	c.A1042C	p.I348L	exonic	ENSG00000144671.10	.	nonsynonymous SNV	ENSG00000144671.10:ENST00000273173.4:exon5:c.A1042C:p.I348L	3p22.2	C3N-00249	.	.	.	.	.	.	.	.	.	3.20	T	T	P	P	D	N	L	T	N	0.309	T	T	D	0.229	0.564	0.178	0.514	T	T	T	T	D	T	2.061	19.720	0.944	N	N	-0.770	0.699	-0.878	0.650	0.975	0.497	0.563	0.547	0.542	.	4.140	2.940	0.439	1.169	0.691	0.031	0.904	0.533	553	Major_facilitator_superfamily_domain	.	.	.	SLC22A14	208	0	350	96	0.2152466367713	TRUE	TRUE
ENSG00000087116.16	.	BCM	GRCh38.p13	chr5	179121661	179121661	+	T	T	C	Missense_Mutation	SNP	ENST00000251582.12	exon21	c.A3178G	p.K1060E	exonic	ENSG00000087116.16	.	nonsynonymous SNV	ENSG00000087116.16:ENST00000251582.12:exon21:c.A3178G:p.K1060E	5q35.3	C3N-00249	.	.	.	.	.	.	.	.	.	7.19	T	T	B	B	D	D	M	T	N	0.266	T	T	D	0.076	0.258	0.583	0.678	T	T	T	T	D	.	3.100	23.600	0.986	D	D	-0.145	2.037	0.073	2.627	0.999	0.701	0.588	0.717	0.613	.	5.740	5.740	5.394	1.033	0.647	1.000	1.000	0.990	712	PLAC	.	.	.	ADAMTS2	49	0	47	20	0.298507462686567	TRUE	TRUE
ENSG00000155660.11	.	BCM	GRCh38.p13	chr7	149006053	149006053	+	C	C	T	Missense_Mutation	SNP	ENST00000652332.1	exon8	c.G1132A	p.G378S	exonic	ENSG00000155660.11	.	nonsynonymous SNV	ENSG00000155660.11:ENST00000652332.1:exon8:c.G1132A:p.G378S	7q36.1	C3N-00249	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	M	T	N	0.181	T	T	T	0.028	0.234	0.261	0.083	T	T	T	T	T	T	1.265	14.130	0.861	D	D	-0.420	1.340	-0.353	1.459	1.000	0.632	0.698	0.780	0.636	.	5.110	3.310	3.030	1.005	0.599	1.000	0.250	0.236	884	.	.	.	.	PDIA4	158	0	235	78	0.249201277955272	TRUE	TRUE
ENSG00000040341.18	.	BCM	GRCh38.p13	chr8	73617341	73617341	+	T	T	G	Missense_Mutation	SNP	ENST00000524300.6	exon7	c.A521C	p.K174T	exonic	ENSG00000040341.18	.	nonsynonymous SNV	ENSG00000040341.18:ENST00000524300.6:exon7:c.A521C:p.K174T	8q21.11	C3N-00249	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.747	D	D	D	0.855	0.600	0.467	0.859	D	T	D	D	D	D	4.041	27.300	0.998	D	D	0.759	8.031	0.713	8.012	1.000	0.706	0.725	0.710	0.714	.	5.100	5.100	7.456	1.138	0.665	1.000	0.999	0.993	894	Double-stranded_RNA-binding_domain	.	.	.	STAU2	251	0	236	52	0.180555555555556	TRUE	TRUE
ENSG00000174885.12	.	BCM	GRCh38.p13	chr11	280354	280354	+	G	G	C	Missense_Mutation	SNP	ENST00000312165.5	exon4	c.G620C	p.G207A	exonic	ENSG00000174885.12	.	nonsynonymous SNV	ENSG00000174885.12:ENST00000312165.5:exon4:c.G620C:p.G207A	11p15.5	C3N-00249	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	N	D	.	D	D	0.730	D	D	D	0.804	0.967	0.381	.	D	D	D	D	D	T	4.297	29.600	0.996	D	D	0.702	7.143	0.542	5.563	1.000	0.765	0.628	0.600	0.639	.	3.400	2.480	9.339	1.089	0.490	1.000	1.000	0.995	889	NACHT_nucleoside_triphosphatase	.	.	.	NLRP6	74	0	144	46	0.242105263157895	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227342	25227342	+	T	T	C	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A182G	p.Q61R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A182G:p.Q61R	12p12.1	C3N-00249	.	.	.	.	.	.	.	.	rs121913240	18.20	D	D	B	B	D	D	M	D	D	0.816	D	D	D	0.799	0.671	0.925	2.034	D	D	D	D	D	D	2.716	22.900	0.998	D	D	0.433	4.556	0.532	5.469	1.000	0.722	0.710	0.710	0.735	.	5.770	5.770	8.004	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55498739;OCCURENCE=1(oesophagus),3(genital_tract),1(cervix),40(large_intestine),1(central_nervous_system),2(biliary_tract),3(stomach),11(haematopoietic_and_lymphoid_tissue),40(pancreas),5(skin),1(prostate),11(lung),43(thyroid),1(upper_aerodigestive_tract)	KRAS	227	0	235	65	0.216666666666667	TRUE	TRUE
ENSG00000256870.3	.	BCM	GRCh38.p13	chr12	101209509	101209509	+	T	T	C	Missense_Mutation	SNP	ENST00000536262.3	exon1	c.A340G	p.S114G	exonic	ENSG00000256870.3	.	nonsynonymous SNV	ENSG00000256870.3:ENST00000536262.3:exon1:c.A340G:p.S114G	12q23.2	C3N-00249	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	H	D	D	0.933	D	D	D	0.947	0.773	0.577	0.508	T	D	D	D	D	.	4.162	28.300	0.998	D	D	0.918	11.518	0.845	11.588	1.000	0.487	0.574	0.607	0.530	.	5.490	5.490	8.017	1.138	0.609	1.000	0.995	0.975	882	.	.	.	.	SLC5A8	87	0	83	27	0.245454545454545	TRUE	TRUE
ENSG00000198718.13	.	BCM	GRCh38.p13	chr14	45004214	45004214	+	C	C	T	Missense_Mutation	SNP	ENST00000361577.7	exon4	c.C2492T	p.S831F	exonic	ENSG00000198718.13	.	nonsynonymous SNV	ENSG00000198718.13:ENST00000361577.7:exon4:c.C2492T:p.S831F	14q21.2	C3N-00249	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	N	D	.	T	D	0.589	T	T	D	0.135	0.175	0.405	0.357	T	T	T	T	D	T	2.866	23.100	0.998	D	N	0.344	4.015	0.312	3.787	0.080	0.615	0.602	0.659	0.636	.	3.740	3.740	2.527	0.797	0.473	0.992	0.975	0.707	762	.	.	.	.	TOGARAM1	328	0	540	86	0.137380191693291	TRUE	TRUE
ENSG00000126822.17	.	BCM	GRCh38.p13	chr14	64741445	64741445	+	G	G	T	Missense_Mutation	SNP	ENST00000247226.13	exon16	c.G1928T	p.S643I	exonic	ENSG00000126822.17	.	nonsynonymous SNV	ENSG00000126822.17:ENST00000247226.13:exon16:c.G1928T:p.S643I	14q23.3	C3N-00249	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.767	T	T	D	0.282	0.321	0.658	0.672	T	T	D	D	D	D	3.753	25.600	0.996	D	D	0.784	8.482	0.784	9.656	1.000	0.672	0.574	0.702	0.636	.	5.780	5.780	4.338	1.176	0.676	1.000	0.998	0.829	407	.	.	.	.	PLEKHG3	194	0	258	64	0.198757763975155	TRUE	NA
ENSG00000185070.11	.	BCM	GRCh38.p13	chr14	85621528	85621528	+	C	C	A	Missense_Mutation	SNP	ENST00000330753.6	exon2	c.C14A	p.T5N	exonic	ENSG00000185070.11	.	nonsynonymous SNV	ENSG00000185070.11:ENST00000330753.6:exon2:c.C14A:p.T5N	14q31.3	C3N-00249	.	.	.	.	.	.	.	.	.	7.20	D	D	P	P	D	D	L	T	N	0.424	T	T	T	0.164	0.289	0.374	0.477	T	T	T	T	D	T	2.983	23.400	0.992	D	D	0.383	4.241	0.438	4.640	1.000	0.707	0.574	0.574	0.714	.	5.880	4.970	3.533	1.026	0.597	1.000	1.000	0.999	944	.	.	.	.	FLRT2	113	1	149	39	0.207446808510638	TRUE	TRUE
ENSG00000254585.5	.	BCM	GRCh38.p13	chr15	23644876	23644876	+	C	C	A	Missense_Mutation	SNP	ENST00000650528.1	exon1	c.G2867T	p.S956I	exonic	ENSG00000254585.5	.	nonsynonymous SNV	ENSG00000254585.5:ENST00000650528.1:exon1:c.G2867T:p.S956I	15q11.2	C3N-00249	.	.	.	.	.	.	.	.	.	4.11	.	D	.	.	.	N	.	.	.	0.126	.	.	D	.	.	0.043	0.348	T	T	T	T	D	T	3.152	23.700	0.996	D	N	0.126	2.989	0.130	2.861	0.955	0.581	0.574	0.576	0.613	.	3.940	3.010	0.508	0.103	0.599	0.001	0.452	0.999	988	.	.	.	.	MAGEL2	159	0	247	81	0.246951219512195	TRUE	TRUE
ENSG00000153684.15	.	BCM	GRCh38.p13	chr15	28385229	28385229	+	G	G	A	Missense_Mutation	SNP	ENST00000526619.6	exon11	c.G364A	p.E122K	exonic	ENSG00000153684.15	.	nonsynonymous SNV	ENSG00000153684.15:ENST00000526619.6:exon11:c.G364A:p.E122K	15q13.1	C3N-00249	.	.	.	.	.	.	.	.	.	1.14	T	T	B	B	.	D	.	T	N	0.073	.	.	T	.	.	0.068	1.565	.	T	T	T	.	T	0.086	1.968	0.450	N	N	.	.	.	.	0.000	0.487	0.574	0.574	0.564	.	0.647	-1.290	0.059	-5.325	-0.946	0.001	0.000	0.001	421	.	.	.	.	GOLGA8F	228	0	363	28	0.0716112531969309	NA	TRUE
ENSG00000273540.4	.	BCM	GRCh38.p13	chr15	86522898	86522898	+	G	G	A	Missense_Mutation	SNP	ENST00000441037.7	exon19	c.G2644A	p.G882S	exonic	ENSG00000273540.4	.	nonsynonymous SNV	ENSG00000273540.4:ENST00000441037.7:exon19:c.G2644A:p.G882S	15q25.3	C3N-00249	.	.	.	.	.	.	.	.	.	8.19	T	.	D	D	D	D	L	T	N	.	T	T	T	0.259	0.520	0.371	0.044	T	T	T	T	D	D	3.124	23.700	0.998	D	D	0.598	5.902	0.639	6.754	0.366	0.487	0.574	0.574	0.564	.	5.930	5.930	4.972	1.176	0.676	1.000	0.941	0.767	942	Peptidase_M14,_carboxypeptidase_A	.	.	.	AGBL1	173	0	270	126	0.318181818181818	TRUE	TRUE
ENSG00000166816.14	.	BCM	GRCh38.p13	chr16	75112502	75112502	+	C	C	T	Missense_Mutation	SNP	ENST00000300051.8	exon11	c.G1378A	p.G460R	exonic	ENSG00000166816.14	.	nonsynonymous SNV	ENSG00000166816.14:ENST00000300051.8:exon11:c.G1378A:p.G460R	16q23.1	C3N-00249	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.929	D	D	D	0.955	0.932	0.978	0.956	T	D	D	D	D	D	4.256	29.200	0.999	D	D	0.989	13.567	0.862	12.220	1.000	0.560	0.551	0.269	0.632	.	5.270	5.270	7.190	1.026	0.599	1.000	0.829	0.564	719	FAD-linked_oxidase,_C-terminal	.	.	.	LDHD	118	0	216	12	0.0526315789473684	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7676176	7676176	+	T	T	A	Nonsense_Mutation	SNP	ENST00000269305.8	exon4	c.A193T	p.R65X	exonic	ENSG00000141510.17	.	stopgain	ENSG00000141510.17:ENST00000269305.8:exon4:c.A193T:p.R65X	17p13.1	C3N-00249	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	A	.	.	.	0.836	.	.	.	.	.	.	.	.	.	D	D	.	.	4.914	33	0.963	N	N	-0.194	1.892	-0.612	1.028	0.204	0.722	0.702	0.699	0.735	.	3.840	-2.610	0.219	0.119	0.661	0.000	0.001	0.002	434	.	.	.	ID=COSV52689560;OCCURENCE=1(breast),1(large_intestine),1(ovary),1(haematopoietic_and_lymphoid_tissue),5(urinary_tract),7(lung)	TP53	261	0	276	93	0.252032520325203	TRUE	TRUE
ENSG00000141161.11	.	BCM	GRCh38.p13	chr17	35177041	35177041	+	G	G	A	Missense_Mutation	SNP	ENST00000268876.9	exon16	c.G2056A	p.G686S	exonic	ENSG00000141161.11	.	nonsynonymous SNV	ENSG00000141161.11:ENST00000268876.9:exon16:c.G2056A:p.G686S	17q12	C3N-00249	.	.	.	.	.	.	.	.	.	14.20	D	T	D	D	D	D	M	T	D	0.800	T	T	D	0.273	0.350	0.845	0.138	T	T	D	D	D	D	3.463	24.600	0.999	D	D	0.531	5.288	0.583	6.016	1.000	0.487	0.574	0.547	0.530	.	5.080	5.080	6.662	1.164	0.662	1.000	1.000	0.998	907	.	.	.	.	UNC45B	124	0	230	51	0.181494661921708	TRUE	NA
ENSG00000183048.12	.	BCM	GRCh38.p13	chr17	81716026	81716026	+	A	A	G	Missense_Mutation	SNP	ENST00000350690.10	exon5	c.A395G	p.K132R	exonic	ENSG00000183048.12;ENSG00000262660.1	.	nonsynonymous SNV	ENSG00000183048.12:ENST00000350690.10:exon5:c.A395G:p.K132R,ENSG00000262660.1:ENST00000571730.1:exon9:c.A860G:p.K287R	17q25.3	C3N-00249	.	.	.	.	.	.	.	.	.	11.20	D	T	B	B	D	D	L	T	D	0.483	T	T	D	0.514	0.401	0.786	0.293	T	D	D	T	D	D	2.840	23.100	0.998	D	D	-0.219	1.825	-0.146	1.920	1.000	0.672	0.702	0.723	0.563	.	3.900	3.900	5.779	1.180	0.660	1.000	0.877	0.534	.	.	.	.	.	SLC25A10	132	0	112	59	0.345029239766082	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51065555	51065555	+	G	G	A	Missense_Mutation	SNP	ENST00000342988.8	exon9	c.G1088A	p.C363Y	exonic	ENSG00000141646.14	.	nonsynonymous SNV	ENSG00000141646.14:ENST00000342988.8:exon9:c.G1088A:p.C363Y	18q21.2	C3N-00249	.	.	.	.	.	.	.	.	rs876660556	20.20	D	D	D	D	D	D	H	D	D	0.982	D	D	D	0.977	0.919	0.992	4.220	D	D	D	D	D	D	4.241	29.000	0.998	D	D	1.085	16.898	1.025	20.435	1.000	0.707	0.725	0.725	0.714	.	5.860	5.860	9.808	1.176	0.676	1.000	1.000	0.995	904	SMAD_domain,_Dwarfin-type	.	.	ID=COSV61684006;OCCURENCE=2(large_intestine),1(biliary_tract),1(stomach)	SMAD4	209	0	176	76	0.301587301587302	TRUE	TRUE
ENSG00000104899.8	.	BCM	GRCh38.p13	chr19	2250751	2250751	+	C	C	T	Missense_Mutation	SNP	ENST00000221496.5	exon3	c.C655T	p.R219C	exonic	ENSG00000104899.8	.	nonsynonymous SNV	ENSG00000104899.8:ENST00000221496.5:exon3:c.C655T:p.R219C	19p13.3	C3N-00249	0.0003	0	0	0	0	0	0	0.0004	rs747303126	7.20	T	D	D	P	N	N	L	D	D	0.142	T	D	D	0.260	0.602	0.801	0.003	T	D	T	T	T	T	2.368	21.900	0.959	N	N	-0.162	1.986	-0.367	1.433	0.999	0.650	0.551	0.607	0.621	.	4.530	3.460	0.880	-0.029	0.511	0.000	0.001	0.017	982	Anti-Mullerian_hormone,_N-terminal	.	.	.	AMH	157	0	220	104	0.320987654320988	TRUE	NA
ENSG00000004777.18	.	BCM	GRCh38.p13	chr19	35787546	35787546	+	G	G	A	Missense_Mutation	SNP	ENST00000314737.9	exon21	c.G2498A	p.R833Q	exonic	ENSG00000004777.18	.	nonsynonymous SNV	ENSG00000004777.18:ENST00000314737.9:exon21:c.G2498A:p.R833Q	19q13.12	C3N-00249	8.792e-06	0	0	0	0	1.615e-05	0	0	rs763084663	8.18	D	T	D	D	D	D	.	T	N	0.346	T	T	T	0.084	.	0.413	0.482	T	.	T	T	D	D	3.355	24.300	0.999	D	N	0.233	3.452	0.257	3.477	0.388	0.706	0.710	0.723	0.655	.	4.770	3.650	1.058	1.176	0.676	0.002	0.993	0.960	744	.	.	.	ID=COSV99139014;OCCURENCE=1(stomach)	ARHGAP33	206	0	386	35	0.0831353919239905	TRUE	NA
ENSG00000125966.10	.	BCM	GRCh38.p13	chr20	35271748	35271748	+	G	G	A	Missense_Mutation	SNP	ENST00000246186.8	exon8	c.G1513A	p.A505T	exonic	ENSG00000125966.10	.	nonsynonymous SNV	ENSG00000125966.10:ENST00000246186.8:exon8:c.G1513A:p.A505T	20q11.22	C3N-00249	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	N	T	N	0.127	T	T	T	0.106	0.328	0.432	0.525	T	T	T	T	D	D	2.085	19.900	0.901	D	N	-0.281	1.662	0.008	2.386	1.000	0.635	0.551	0.644	0.664	.	5.600	5.600	4.371	1.176	0.676	1.000	0.992	0.937	439	Hemopexin-like_domain	.	.	.	MMP24	287	0	493	117	0.191803278688525	TRUE	NA
ENSG00000198765.12	.	BCM	GRCh38.p13	chr1	114926277	114926277	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000198765.12	ENST00000369522.8:exon22:c.1801-1G>A	.	.	1p13.2	C3N-00249	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.278	33	0.992	D	.	1.005	14.082	0.821	10.762	0.002	0.061	0.063	0.063	0.057	0.958	4.370	4.370	5.006	1.155	0.618	1.000	0.998	0.987	265	.	.	.	.	SYCP1	29	0	19	12	0.387096774193548	NA	TRUE
ENSG00000126838.10	.	BCM	GRCh38.p13	chr12	9161117	9161117	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000126838.10	ENST00000261336.7:exon23:c.2789-1G>T	.	.	12p13.31	C3N-00249	.	.	.	.	.	.	.	.	.	3.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	T	.	.	3.157	23.800	0.972	D	.	0.597	5.892	0.296	3.691	0.600	0.054	0.060	0.060	0.059	0.915	3.800	3.800	2.469	0.710	0.530	0.968	0.138	0.043	657	.	.	.	.	PZP	91	1	123	40	0.245398773006135	TRUE	TRUE
ENSG00000116213.16	.	BCM	GRCh38.p13	chr1	3635208	3635208	+	G	G	A	Silent	SNP	ENST00000270708.12	exon7	c.C690T	p.A230A	exonic	ENSG00000116213.16	.	synonymous SNV	ENSG00000116213.16:ENST00000270708.12:exon7:c.C690T:p.A230A	1p36.32	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WRAP73	257	0	352	79	0.183294663573086	TRUE	TRUE
ENSG00000197532.2	.	BCM	GRCh38.p13	chr1	158548004	158548004	+	G	G	A	Silent	SNP	ENST00000641622.1	exon2	c.C102T	p.S34S	exonic	ENSG00000197532.2	.	synonymous SNV	ENSG00000197532.2:ENST00000641622.1:exon2:c.C102T:p.S34S	1q23.1	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56929514;OCCURENCE=2(skin)	OR6Y1	260	4	364	59	0.139479905437352	TRUE	TRUE
ENSG00000173769.4	.	BCM	GRCh38.p13	chr3	44243808	44243808	+	G	G	A	Silent	SNP	ENST00000309765.4	exon2	c.G1302A	p.P434P	exonic	ENSG00000173769.4	.	synonymous SNV	ENSG00000173769.4:ENST00000309765.4:exon2:c.G1302A:p.P434P	3p21.31	C3N-00249	0.0012	0.0009	0	0.0049	0	0.0006	0	0.0022	rs144334708	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59066058;OCCURENCE=1(large_intestine),1(biliary_tract),2(pancreas)	TOPAZ1	189	0	238	52	0.179310344827586	TRUE	TRUE
ENSG00000261934.2	.	BCM	GRCh38.p13	chr5	141403189	141403189	+	G	G	C	Silent	SNP	ENST00000573521.1	exon1	c.G237C	p.P79P	exonic	ENSG00000261934.2	.	synonymous SNV	ENSG00000261934.2:ENST00000573521.1:exon1:c.G237C:p.P79P	5q31.3	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHGA9	192	0	296	81	0.214854111405836	TRUE	TRUE
ENSG00000135298.14	.	BCM	GRCh38.p13	chr6	69339393	69339393	+	G	G	A	Silent	SNP	ENST00000370598.6	exon26	c.G3348A	p.A1116A	exonic	ENSG00000135298.14	.	synonymous SNV	ENSG00000135298.14:ENST00000370598.6:exon26:c.G3348A:p.A1116A	6q13	C3N-00249	5.767e-05	0	0	0	0	0.0001	0	0	rs188479310	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADGRB3	112	0	181	32	0.150234741784038	TRUE	NA
ENSG00000198670.12	.	BCM	GRCh38.p13	chr6	160650430	160650430	+	C	C	T	Silent	SNP	ENST00000316300.10	exon2	c.G117A	p.T39T	exonic	ENSG00000198670.12	.	synonymous SNV	ENSG00000198670.12:ENST00000316300.10:exon2:c.G117A:p.T39T	6q26	C3N-00249	9.09e-05	0	0.0002	0.0008	0	2.997e-05	0	0	rs372624567	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60297950;OCCURENCE=3(liver),3(large_intestine),1(stomach),1(endometrium)	LPA	407	0	687	187	0.21395881006865	TRUE	TRUE
ENSG00000146731.11	.	BCM	GRCh38.p13	chr7	56058485	56058485	+	C	C	T	Silent	SNP	ENST00000275603.9	exon7	c.C849T	p.G283G	exonic	ENSG00000146731.11	.	synonymous SNV	ENSG00000146731.11:ENST00000275603.9:exon7:c.C849T:p.G283G	7p11.2	C3N-00249	3.344e-05	0	0	0	0	3.034e-05	0	0.0001	rs754612296	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51906522;OCCURENCE=1(liver)	CCT6A	73	0	93	28	0.231404958677686	NA	TRUE
ENSG00000106333.13	.	BCM	GRCh38.p13	chr7	100606542	100606542	+	C	C	T	Silent	SNP	ENST00000223061.6	exon6	c.C852T	p.P284P	exonic	ENSG00000106333.13	.	synonymous SNV	ENSG00000106333.13:ENST00000223061.6:exon6:c.C852T:p.P284P	7q22.1	C3N-00249	1.653e-05	0	0	0	0	1.503e-05	0	6.078e-05	rs757331910	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCOLCE	139	0	143	90	0.386266094420601	TRUE	NA
ENSG00000132275.11	.	BCM	GRCh38.p13	chr11	6600980	6600980	+	A	A	G	Silent	SNP	ENST00000254605.11	exon4	c.T993C	p.H331H	exonic	ENSG00000132275.11	.	synonymous SNV	ENSG00000132275.11:ENST00000254605.11:exon4:c.T993C:p.H331H	11p15.4	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RRP8	218	0	337	69	0.169950738916256	TRUE	TRUE
ENSG00000111358.14	.	BCM	GRCh38.p13	chr12	123659530	123659530	+	G	G	A	Silent	SNP	ENST00000543341.7	exon10	c.G630A	p.T210T	exonic	ENSG00000111358.14	.	synonymous SNV	ENSG00000111358.14:ENST00000543341.7:exon10:c.G630A:p.T210T	12q24.31	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GTF2H3	401	0	574	147	0.203883495145631	TRUE	TRUE
ENSG00000211921.1	.	BCM	GRCh38.p13	chr14	105902660	105902660	+	C	C	A	Silent	SNP	ENST00000390581.1	exon1	c.G12T	p.V4V	exonic	ENSG00000211921.1	.	synonymous SNV	ENSG00000211921.1:ENST00000390581.1:exon1:c.G12T:p.V4V	14q32.33	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHD5-12	123	0	280	33	0.105431309904153	NA	TRUE
ENSG00000007541.17	.	BCM	GRCh38.p13	chr16	578466	578466	+	C	C	T	Silent	SNP	ENST00000026218.9	exon5	c.C1030T	p.L344L	exonic	ENSG00000007541.17	.	synonymous SNV	ENSG00000007541.17:ENST00000026218.9:exon5:c.C1030T:p.L344L	16p13.3	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PIGQ	133	0	298	59	0.165266106442577	TRUE	TRUE
ENSG00000178773.15	.	BCM	GRCh38.p13	chr16	89588779	89588779	+	C	C	T	Silent	SNP	ENST00000268720.9	exon12	c.C1257T	p.S419S	exonic	ENSG00000178773.15	.	synonymous SNV	ENSG00000178773.15:ENST00000268720.9:exon12:c.C1257T:p.S419S	16q24.3	C3N-00249	8.328e-05	0.0002	0	0	0	0.0001	0	6.061e-05	rs143506526	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPNE7	185	0	233	73	0.238562091503268	TRUE	NA
ENSG00000120071.14	.	BCM	GRCh38.p13	chr17	46031683	46031683	+	C	C	T	Silent	SNP	ENST00000432791.6	exon15	c.G3111A	p.R1037R	exonic	ENSG00000120071.14	.	synonymous SNV	ENSG00000120071.14:ENST00000432791.6:exon15:c.G3111A:p.R1037R	17q21.31	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KANSL1	94	0	119	34	0.222222222222222	TRUE	TRUE
ENSG00000227500.10	.	BCM	GRCh38.p13	chr19	1918916	1918916	+	G	G	A	Silent	SNP	ENST00000316097.13	exon5	c.G321A	p.A107A	exonic	ENSG00000227500.10	.	synonymous SNV	ENSG00000227500.10:ENST00000316097.13:exon5:c.G321A:p.A107A	19p13.3	C3N-00249	3.651e-05	0	0.0002	0	0	4.356e-05	0	0	rs370734476	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60192391;OCCURENCE=1(stomach)	SCAMP4	212	0	241	59	0.196666666666667	TRUE	TRUE
ENSG00000178093.14	.	BCM	GRCh38.p13	chr19	19514621	19514621	+	G	G	A	Silent	SNP	ENST00000585580.4	exon1	c.C807T	p.A269A	exonic	ENSG00000178093.14	.	synonymous SNV	ENSG00000178093.14:ENST00000585580.4:exon1:c.C807T:p.A269A	19p13.11	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TSSK6	68	0	91	33	0.266129032258065	TRUE	TRUE
ENSG00000099338.23	.	BCM	GRCh38.p13	chr19	38370198	38370198	+	C	C	T	Silent	SNP	ENST00000409235.8	exon28	c.C3153T	p.T1051T	exonic	ENSG00000099338.23	.	synonymous SNV	ENSG00000099338.23:ENST00000409235.8:exon28:c.C3153T:p.T1051T	19q13.2	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CATSPERG	232	1	416	69	0.142268041237113	TRUE	NA
ENSG00000185008.17	.	BCM	GRCh38.p13	chr3	77642683	77642683	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000185008.17	.	.	.	3p12.3	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ROBO2	272	0	308	84	0.214285714285714	TRUE	NA
ENSG00000106638.17	.	BCM	GRCh38.p13	chr7	73576642	73576642	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000106638.17	.	.	.	7q11.23	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBL2	180	0	188	65	0.256916996047431	TRUE	NA
ENSG00000240632.6	.	BCM	GRCh38.p13	chr9	81916212	81916212	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000240632.6	.	.	.	9q21.32	C3N-00249	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPATA31D5P	113	0	217	50	0.187265917602996	TRUE	NA
ENSG00000186431.19	.	BCM	GRCh38.p13	chr19	54874288	54874288	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000186431.19	ENST00000355524.8:c.-2C>T	.	.	19q13.42	C3N-00249	3.295e-05	0	0	0	0	1.499e-05	0	0.0002	rs773500089	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100628994;OCCURENCE=1(liver),1(haematopoietic_and_lymphoid_tissue)	FCAR	189	0	244	49	0.167235494880546	TRUE	NA
ENSG00000116809.11	.	BCM	GRCh38.p13	chr1	15948368	15948368	+	G	G	A	Missense_Mutation	SNP	ENST00000375743.8	exon3	c.C128T	p.A43V	exonic	ENSG00000116809.11	.	nonsynonymous SNV	ENSG00000116809.11:ENST00000375743.8:exon3:c.C128T:p.A43V	1p36.13	C3L-00589	8.255e-06	0	0	0	0	1.503e-05	0	0	rs757761976	16.20	D	D	D	D	D	D	M	T	N	0.894	D	D	D	0.727	0.766	0.790	1.238	T	T	D	D	D	D	4.298	29.600	0.999	D	D	0.999	13.878	0.935	15.343	1.000	0.742	0.602	0.775	0.711	.	5.300	5.300	9.962	1.176	0.676	1.000	0.999	0.997	410	BTB/POZ_domain	.	.	ID=COSV100998986;OCCURENCE=1(urinary_tract)	ZBTB17	474	1	959	73	0.0707364341085271	TRUE	NA
ENSG00000142949.17	.	BCM	GRCh38.p13	chr1	43591194	43591194	+	C	C	T	Missense_Mutation	SNP	ENST00000359947.9	exon9	c.C1172T	p.A391V	exonic	ENSG00000142949.17	.	nonsynonymous SNV	ENSG00000142949.17:ENST00000359947.9:exon9:c.C1172T:p.A391V	1p34.2	C3L-00589	2.625e-05	0.0001	0	0	0	3.206e-05	0	0	rs746910917	17.20	D	D	D	D	N	D	H	T	D	0.898	D	D	D	0.578	0.804	0.825	1.597	D	T	D	D	D	D	4.013	27.100	0.999	D	D	0.772	8.254	0.754	8.884	1.000	0.707	0.588	0.723	0.714	.	5.480	5.480	7.905	1.026	0.599	1.000	0.985	0.944	652	Fibronectin_type_III	.	.	ID=COSV63447231;OCCURENCE=2(lung)	PTPRF	97	0	292	26	0.0817610062893082	TRUE	TRUE
ENSG00000116783.15	.	BCM	GRCh38.p13	chr1	74439607	74439607	+	G	G	A	Missense_Mutation	SNP	ENST00000326637.8	exon20	c.G1996A	p.A666T	exonic	ENSG00000116783.15;ENSG00000259030.7	.	nonsynonymous SNV	ENSG00000116783.15:ENST00000326637.8:exon20:c.G1996A:p.A666T,ENSG00000259030.7:ENST00000557284.6:exon22:c.G2338A:p.A780T	1p31.1	C3L-00589	0.0008	0.0084	0.0005	0	0	1.5e-05	0.0011	0	rs148931950	10.19	T	D	D	P	D	D	N	D	N	0.648	T	T	D	0.549	.	0.844	0.078	.	T	T	D	T	D	2.997	23.400	0.999	D	D	0.466	4.784	0.500	5.156	0.969	0.487	0.574	0.574	0.564	.	5.870	4.940	5.362	1.106	0.509	1.000	0.988	0.382	890	Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	ID=COSV100437552;OCCURENCE=1(prostate)	TNNI3K	169	0	202	20	0.0900900900900901	TRUE	NA
ENSG00000085433.15	.	BCM	GRCh38.p13	chr1	108991294	108991294	+	C	C	A	Missense_Mutation	SNP	ENST00000369962.7	exon9	c.G1727T	p.G576V	exonic	ENSG00000085433.15	.	nonsynonymous SNV	ENSG00000085433.15:ENST00000369962.7:exon9:c.G1727T:p.G576V	1p13.3	C3L-00589	.	.	.	.	.	.	.	.	.	4.20	D	T	B	B	N	D	L	T	N	0.224	T	T	T	0.068	0.383	0.155	0.054	T	T	T	T	T	D	3.255	24.000	0.967	D	N	-0.160	1.992	0.033	2.476	0.004	0.707	0.546	0.602	0.714	.	5.230	4.260	1.262	1.008	0.599	1.000	1.000	0.994	861	.	.	.	.	WDR47	248	1	109	11	0.0916666666666667	TRUE	TRUE
ENSG00000198929.13	.	BCM	GRCh38.p13	chr1	162367087	162367087	+	C	C	T	Missense_Mutation	SNP	ENST00000361897.10	exon10	c.C1141T	p.R381C	exonic	ENSG00000198929.13	.	nonsynonymous SNV	ENSG00000198929.13:ENST00000361897.10:exon10:c.C1141T:p.R381C	1q23.3	C3L-00589	.	.	.	.	.	.	.	.	.	18.20	D	D	D	P	D	D	M	D	D	0.690	D	D	D	0.788	0.669	0.851	2.365	T	D	D	D	D	D	4.228	28.900	0.999	D	D	0.434	4.559	0.435	4.618	1.000	0.706	0.590	0.710	0.636	.	4.800	3.880	7.245	0.952	0.599	1.000	0.973	0.823	862	.	.	.	ID=COSV62633557;OCCURENCE=1(prostate)	NOS1AP	231	0	703	48	0.0639147802929427	TRUE	TRUE
ENSG00000116147.17	.	BCM	GRCh38.p13	chr1	175362804	175362804	+	G	G	A	Nonsense_Mutation	SNP	ENST00000367674.7	exon14	c.C2713T	p.R905X	exonic	ENSG00000116147.17	.	stopgain	ENSG00000116147.17:ENST00000367674.7:exon14:c.C2713T:p.R905X	1q25.1	C3L-00589	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.983	.	.	.	.	.	.	.	.	.	D	D	.	.	8.118	41	0.998	D	N	0.682	6.876	0.536	5.507	0.938	0.601	0.590	0.547	0.620	.	5.790	3.730	2.592	1.176	0.676	0.998	0.997	0.975	595	Fibronectin_type_III	.	.	.	TNR	137	0	206	16	0.0720720720720721	TRUE	NA
ENSG00000152092.16	.	BCM	GRCh38.p13	chr1	176957766	176957766	+	G	G	A	Missense_Mutation	SNP	ENST00000361833.7	exon11	c.C1799T	p.P600L	exonic	ENSG00000152092.16	.	nonsynonymous SNV	ENSG00000152092.16:ENST00000361833.7:exon11:c.C1799T:p.P600L	1q25.2	C3L-00589	2.488e-05	0	8.717e-05	0.0001	0	1.506e-05	0	0	rs770266633	15.19	D	D	D	D	D	D	.	T	D	0.987	T	T	D	0.481	.	0.608	0.870	D	T	D	D	D	D	4.061	27.400	0.999	D	D	0.724	7.469	0.751	8.815	1.000	0.713	0.574	0.609	0.564	.	5.580	5.580	9.564	1.176	0.674	1.000	0.716	0.714	697	.	.	.	ID=COSV56089388;OCCURENCE=1(soft_tissue)	ASTN1	266	2	529	30	0.0536672629695885	TRUE	TRUE
ENSG00000009790.15	.	BCM	GRCh38.p13	chr1	209775620	209775620	+	C	C	T	Nonsense_Mutation	SNP	ENST00000367025.8	exon11	c.C937T	p.Q313X	exonic	ENSG00000009790.15	.	stopgain	ENSG00000009790.15:ENST00000367025.8:exon11:c.C937T:p.Q313X	1q32.2	C3L-00589	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.346	.	.	.	.	.	.	.	.	.	D	D	.	.	7.202	37	0.997	D	N	0.913	11.395	0.737	8.505	1.000	0.646	0.696	0.489	0.613	.	4.780	4.780	2.159	1.026	0.599	1.000	0.993	0.867	866	.	.	.	.	TRAF3IP3	133	1	205	88	0.300341296928328	TRUE	TRUE
ENSG00000169214.4	.	BCM	GRCh38.p13	chr1	247711884	247711884	+	G	G	A	Missense_Mutation	SNP	ENST00000641470.1	exon3	c.C872T	p.T291M	exonic	ENSG00000169214.4	.	nonsynonymous SNV	ENSG00000169214.4:ENST00000641470.1:exon3:c.C872T:p.T291M	1q44	C3L-00589	4.943e-05	0	0	0.0006	0	1.499e-05	0	0	rs186143987	4.20	D	D	P	B	D	N	M	T	N	0.334	T	T	T	0.152	.	0.461	0.312	T	T	T	T	T	T	2.030	19.490	0.936	N	N	-0.475	1.227	-0.715	0.878	0.000	0.487	0.574	0.574	0.564	.	3.490	1.490	0.674	-0.027	0.593	0.009	0.068	0.214	952	.	.	.	ID=COSV57467500;OCCURENCE=1(large_intestine),1(urinary_tract)	OR6F1	141	0	231	20	0.0796812749003984	TRUE	TRUE
ENSG00000186487.20	.	BCM	GRCh38.p13	chr2	1943020	1943020	+	T	T	A	Missense_Mutation	SNP	ENST00000647738.2	exon9	c.A467T	p.E156V	exonic	ENSG00000186487.20	.	nonsynonymous SNV	ENSG00000186487.20:ENST00000647738.2:exon9:c.A467T:p.E156V	2p25.3	C3L-00589	.	.	.	.	.	.	.	.	.	4.20	T	T	P	P	N	D	L	T	N	0.350	T	T	T	0.118	0.283	0.196	0.619	T	T	T	T	D	T	2.488	22.400	0.974	D	D	0.173	3.187	0.198	3.172	1.000	0.487	0.574	0.547	0.564	.	5.370	5.370	7.128	1.138	0.665	1.000	0.395	0.672	773	.	.	.	.	MYT1L	101	1	184	17	0.0845771144278607	TRUE	TRUE
ENSG00000186487.20	.	BCM	GRCh38.p13	chr2	1943063	1943063	+	C	C	T	Missense_Mutation	SNP	ENST00000647738.2	exon9	c.G424A	p.D142N	exonic	ENSG00000186487.20	.	nonsynonymous SNV	ENSG00000186487.20:ENST00000647738.2:exon9:c.G424A:p.D142N	2p25.3	C3L-00589	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	U	D	L	T	N	0.319	T	T	T	0.095	0.277	0.366	0.514	T	T	T	T	T	T	1.625	16.530	0.930	D	D	-0.369	1.452	-0.265	1.639	1.000	0.487	0.574	0.547	0.564	.	4.530	4.530	5.274	1.026	0.599	1.000	0.013	0.122	773	.	.	.	ID=COSV67720977;OCCURENCE=1(breast)	MYT1L	174	0	297	26	0.0804953560371517	TRUE	TRUE
ENSG00000119771.15	.	BCM	GRCh38.p13	chr2	23642551	23642551	+	T	T	C	Missense_Mutation	SNP	ENST00000486442.6	exon5	c.T641C	p.L214P	exonic	ENSG00000119771.15	.	nonsynonymous SNV	ENSG00000119771.15:ENST00000486442.6:exon5:c.T641C:p.L214P	2p24.1	C3L-00589	.	.	.	.	.	.	.	.	.	6.17	D	T	.	.	.	D	N	D	N	0.351	T	T	D	0.355	0.214	0.716	.	T	T	T	T	D	T	2.833	23.100	0.992	D	N	0.133	3.018	0.253	3.453	1.000	0.646	0.654	0.645	0.636	.	5.160	5.160	3.510	1.137	0.665	1.000	1.000	1.000	930	.	.	.	.	KLHL29	57	0	186	33	0.150684931506849	TRUE	TRUE
ENSG00000066032.18	.	BCM	GRCh38.p13	chr2	79744519	79744519	+	G	G	A	Missense_Mutation	SNP	ENST00000402739.8	exon2	c.G235A	p.A79T	exonic	ENSG00000066032.18	.	nonsynonymous SNV	ENSG00000066032.18:ENST00000402739.8:exon2:c.G235A:p.A79T	2p12	C3L-00589	2.5e-05	0	0.0003	0	0	0	0	0	rs377364195	16.20	D	D	D	P	D	D	M	T	D	0.947	T	T	D	0.520	.	0.809	1.452	D	D	D	D	D	D	4.092	27.700	0.999	D	D	0.810	8.981	0.808	10.368	1.000	0.693	0.574	0.659	0.564	.	5.500	5.500	10.003	1.176	0.618	1.000	0.999	0.992	943	.	.	.	.	CTNNA2	187	0	210	22	0.0948275862068965	TRUE	NA
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178566151	178566151	+	-	NA	T	Frame_Shift_Ins	INS	ENST00000591111.5	exon276	c.75057dupA	p.Y25020Ifs*4	exonic	ENSG00000155657.27	.	frameshift insertion	ENSG00000155657.27:ENST00000591111.5:exon276:c.75057dupA:p.Y25020Ifs*4	2q31.2	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TTN	NA	NA	NA	NA	NA	NA	NA
ENSG00000123989.14	.	BCM	GRCh38.p13	chr2	219541801	219541801	+	C	C	T	Missense_Mutation	SNP	ENST00000243776.11	exon2	c.G703A	p.G235R	exonic	ENSG00000123989.14	.	nonsynonymous SNV	ENSG00000123989.14:ENST00000243776.11:exon2:c.G703A:p.G235R	2q35	C3L-00589	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	D	0.788	T	T	D	0.333	0.399	0.519	1.097	T	T	D	D	D	D	3.669	25.300	0.998	D	D	0.489	4.948	0.507	5.222	1.000	0.652	0.749	0.522	0.619	.	4.190	4.190	7.776	1.018	0.589	1.000	0.995	0.996	116	.	.	.	ID=COSV60535208;OCCURENCE=1(cervix)	CHPF	151	0	396	41	0.0938215102974828	TRUE	TRUE
ENSG00000066248.15	.	BCM	GRCh38.p13	chr2	232892979	232892979	+	C	C	T	Missense_Mutation	SNP	ENST00000264051.8	exon7	c.G1061A	p.R354H	exonic	ENSG00000066248.15	.	nonsynonymous SNV	ENSG00000066248.15:ENST00000264051.8:exon7:c.G1061A:p.R354H	2q37.1	C3L-00589	1.657e-05	0	0	0.0001	0	1.512e-05	0	0	rs765885436	0.20	T	T	B	B	N	N	N	T	N	0.068	T	T	T	0.118	.	0.496	0.800	T	T	T	T	T	T	0.061	1.766	0.916	N	N	-1.181	0.241	-1.169	0.310	1.000	0.554	0.574	0.602	0.613	.	5.280	-5.750	0.350	-1.639	-1.081	0.952	0.064	0.166	682	Dbl_homology_(DH)_domain	.	.	ID=COSV50916867;OCCURENCE=2(large_intestine)	NGEF	187	0	328	30	0.0837988826815642	TRUE	TRUE
ENSG00000169855.20	.	BCM	GRCh38.p13	chr3	78670227	78670227	+	C	C	T	Missense_Mutation	SNP	ENST00000464233.6	exon11	c.G1417A	p.V473I	exonic	ENSG00000169855.20	.	nonsynonymous SNV	ENSG00000169855.20:ENST00000464233.6:exon11:c.G1417A:p.V473I	3p12.3	C3L-00589	0.0001	0	0	0.0004	0	8.146e-05	0	0.0003	rs778578401	1.20	T	T	B	B	N	N	N	T	N	0.268	T	T	T	0.037	0.379	0.322	0.115	T	T	T	T	T	T	1.591	16.320	0.969	D	N	-0.459	1.258	-0.315	1.534	0.992	0.707	0.670	0.725	0.564	.	5.980	4.130	1.206	-0.230	0.549	0.885	0.632	0.279	692	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV71394145;OCCURENCE=1(large_intestine),2(endometrium)	ROBO1	231	0	337	38	0.101333333333333	TRUE	TRUE
ENSG00000157765.13	.	BCM	GRCh38.p13	chr4	25676197	25676202	+	CACTCG	CACTCG	-	In_Frame_Del	DEL	ENST00000382051.8	exon13	c.1521_1526del	p.T508_R509del	exonic	ENSG00000157765.13	.	nonframeshift deletion	ENSG00000157765.13:ENST00000382051.8:exon13:c.1521_1526del:p.T508_R509del	4p15.2	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC34A2	471	0	759	95	0.111241217798595	TRUE	TRUE
ENSG00000196159.12	.	BCM	GRCh38.p13	chr4	125490585	125490585	+	A	A	C	Missense_Mutation	SNP	ENST00000674496.1	exon17	c.A13763C	p.N4588T	exonic	ENSG00000196159.12	.	nonsynonymous SNV	ENSG00000196159.12:ENST00000674496.1:exon17:c.A13763C:p.N4588T	4q28.1	C3L-00589	.	.	.	.	.	.	.	.	.	8.20	T	D	P	B	U	D	L	T	N	0.684	T	T	D	0.277	0.103	0.204	0.646	D	T	T	T	D	D	2.493	22.400	0.975	D	D	0.142	3.057	0.255	3.464	0.949	0.707	0.574	0.653	0.714	.	4.950	4.950	6.968	1.228	0.658	1.000	0.971	0.997	884	.	.	.	.	FAT4	238	1	332	40	0.10752688172043	TRUE	TRUE
ENSG00000164163.11	.	BCM	GRCh38.p13	chr4	145108105	145108108	+	CTTC	CTTC	-	Frame_Shift_Del	DEL	ENST00000296577.9	exon4	c.280_283del	p.L94Tfs*14	exonic	ENSG00000164163.11	.	frameshift deletion	ENSG00000164163.11:ENST00000296577.9:exon4:c.280_283del:p.L94Tfs*14	4q31.21	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABCE1	254	0	184	10	0.0515463917525773	NA	TRUE
ENSG00000204569.10	.	BCM	GRCh38.p13	chr6	30602616	30602616	+	G	G	A	Missense_Mutation	SNP	ENST00000376511.7	exon19	c.C2033T	p.P678L	exonic	ENSG00000204569.10	.	nonsynonymous SNV	ENSG00000204569.10:ENST00000376511.7:exon19:c.C2033T:p.P678L	6p21.33	C3L-00589	.	.	.	.	.	.	.	.	.	3.19	D	T	B	B	N	D	N	T	N	0.507	T	T	T	0.082	0.353	0.361	0.381	T	T	T	T	T	.	3.084	23.600	0.938	D	N	-0.329	1.544	-0.144	1.926	0.990	0.672	0.577	0.702	0.636	.	4.480	3.610	2.955	1.172	0.614	1.000	0.983	0.994	814	.	.	.	.	PPP1R10	56	0	119	12	0.0916030534351145	TRUE	NA
ENSG00000135297.16	.	BCM	GRCh38.p13	chr6	73482103	73482103	+	C	C	T	Nonsense_Mutation	SNP	ENST00000370300.8	exon9	c.C1399T	p.R467X	exonic	ENSG00000135297.16	.	stopgain	ENSG00000135297.16:ENST00000370300.8:exon9:c.C1399T:p.R467X	6q13	C3L-00589	6.589e-05	9.61e-05	0	0	0.0009	1.498e-05	0	0	rs200583827	5.6	.	.	.	.	D	A	.	.	.	0.956	.	.	.	.	.	.	.	.	.	D	D	.	.	7.960	40	0.997	D	N	0.938	12.080	0.829	11.034	1.000	0.707	0.725	0.725	0.714	.	5.480	5.480	7.525	1.021	0.544	1.000	0.908	0.986	921	GidA_associated_domain_3	.	.	.	MTO1	517	0	533	38	0.0665499124343257	TRUE	NA
ENSG00000168830.8	.	BCM	GRCh38.p13	chr6	87015725	87015725	+	G	G	A	Missense_Mutation	SNP	ENST00000305344.7	exon2	c.G391A	p.A131T	exonic	ENSG00000168830.8	.	nonsynonymous SNV	ENSG00000168830.8:ENST00000305344.7:exon2:c.G391A:p.A131T	6q14.3	C3L-00589	8.336e-06	0	0	0	0	1.508e-05	0	0	rs764472292	4.20	T	T	P	B	U	D	L	T	N	0.372	T	T	T	0.288	0.331	0.865	1.292	T	T	T	T	D	T	2.445	22.300	0.998	D	D	0.277	3.665	0.317	3.819	0.061	0.487	0.574	0.574	0.564	.	4.260	4.260	7.120	0.913	0.485	1.000	0.998	0.976	809	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV100541091;OCCURENCE=1(large_intestine),1(upper_aerodigestive_tract)	HTR1E	47	0	87	9	0.09375	TRUE	NA
ENSG00000135547.9	.	BCM	GRCh38.p13	chr6	125759432	125759432	+	C	C	T	Missense_Mutation	SNP	ENST00000368364.4	exon5	c.C644T	p.T215I	exonic	ENSG00000135547.9	.	nonsynonymous SNV	ENSG00000135547.9:ENST00000368364.4:exon5:c.C644T:p.T215I	6q22.31	C3L-00589	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.055	T	T	T	0.051	0.234	0.417	0.428	T	T	T	T	T	T	1.227	13.850	0.983	N	N	-0.708	0.800	-0.596	1.052	1.000	0.632	0.611	0.780	0.639	.	5.590	3.660	0.822	0.887	0.524	0.000	0.961	0.967	933	.	.	.	.	HEY2	121	0	287	25	0.0801282051282051	TRUE	NA
ENSG00000106128.19	.	BCM	GRCh38.p13	chr7	30975808	30975808	+	G	G	A	Missense_Mutation	SNP	ENST00000326139.7	exon10	c.G914A	p.R305H	exonic	ENSG00000106128.19	.	nonsynonymous SNV	ENSG00000106128.19:ENST00000326139.7:exon10:c.G914A:p.R305H	7p14.3	C3L-00589	8.237e-06	0	8.64e-05	0	0	0	0	0	rs200472991	12.19	D	D	D	D	.	D	M	T	D	0.431	T	T	D	0.310	0.804	0.625	0.528	T	T	T	T	D	D	3.739	25.600	0.999	D	D	0.594	5.864	0.512	5.273	0.847	0.447	0.547	0.547	0.530	.	5.320	3.520	5.200	1.162	0.660	0.998	0.993	0.994	927	GPCR,_family_2-like	.	.	ID=COSV58197595;OCCURENCE=1(large_intestine),1(upper_aerodigestive_tract)	GHRHR	395	1	661	60	0.0832177531206657	TRUE	TRUE
ENSG00000106236.4	.	BCM	GRCh38.p13	chr7	98627261	98627261	+	G	G	A	Missense_Mutation	SNP	ENST00000265634.4	exon4	c.G985A	p.G329R	exonic	ENSG00000106236.4	.	nonsynonymous SNV	ENSG00000106236.4:ENST00000265634.4:exon4:c.G985A:p.G329R	7q22.1	C3L-00589	8.294e-06	9.675e-05	0	0	0	0	0	0	rs375252857	18.20	D	D	D	D	D	D	M	T	D	0.979	D	D	D	0.819	.	0.913	1.239	D	T	D	D	D	D	4.514	32	0.999	D	D	0.949	12.390	0.896	13.562	1.000	0.661	0.590	0.644	0.621	.	5.390	5.390	9.996	1.176	0.676	1.000	0.999	0.901	233	.	.	.	ID=COSV55716710;OCCURENCE=2(large_intestine),1(biliary_tract),1(stomach)	NPTX2	185	0	464	42	0.08300395256917	TRUE	TRUE
ENSG00000055609.18	.	BCM	GRCh38.p13	chr7	152162805	152162805	+	T	T	C	Missense_Mutation	SNP	ENST00000262189.11	exon43	c.A10772G	p.Q3591R	exonic	ENSG00000055609.18	.	nonsynonymous SNV	ENSG00000055609.18:ENST00000262189.11:exon43:c.A10772G:p.Q3591R	7q36.1	C3L-00589	.	.	.	.	.	.	.	.	.	17.20	D	T	D	D	D	D	M	D	D	0.866	D	D	D	0.634	0.234	0.959	0.458	T	T	D	D	D	D	3.699	25.400	0.996	D	D	0.714	7.322	0.706	7.859	1.000	0.722	0.699	0.609	0.636	.	5.510	5.510	7.667	1.138	0.665	1.000	1.000	0.950	809	.	.	.	.	KMT2C	205	0	268	24	0.0821917808219178	TRUE	TRUE
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	2949317	2949317	+	A	A	G	Missense_Mutation	SNP	ENST00000635120.2	exon68	c.T10384C	p.F3462L	exonic	ENSG00000183117.19	.	nonsynonymous SNV	ENSG00000183117.19:ENST00000635120.2:exon68:c.T10384C:p.F3462L	8p23.2	C3L-00589	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	.	T	D	0.928	T	T	D	0.472	0.463	0.503	.	T	T	D	D	D	D	4.185	28.500	0.997	D	D	0.510	5.117	0.579	5.968	1.000	0.487	0.574	0.574	0.564	.	5.600	5.600	9.024	1.300	0.743	1.000	1.000	0.995	915	.	.	.	.	CSMD1	131	0	110	10	0.0833333333333333	TRUE	TRUE
ENSG00000104237.11	.	BCM	GRCh38.p13	chr8	54626035	54626035	+	A	A	G	Missense_Mutation	SNP	ENST00000220676.2	exon4	c.A2153G	p.D718G	exonic	ENSG00000104237.11	.	nonsynonymous SNV	ENSG00000104237.11:ENST00000220676.2:exon4:c.A2153G:p.D718G	8q12.1	C3L-00589	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.121	T	T	T	0.051	0.237	0.285	0.034	T	T	T	T	T	T	0.872	10.140	0.885	N	N	-0.948	0.462	-0.935	0.574	0.021	0.497	0.547	0.547	0.542	.	5.930	0.766	2.378	1.312	0.691	0.476	0.002	0.117	797	.	.	.	.	RP1	325	0	288	32	0.1	TRUE	NA
ENSG00000164794.9	.	BCM	GRCh38.p13	chr8	109974100	109974100	+	C	C	T	Missense_Mutation	SNP	ENST00000524391.6	exon2	c.G289A	p.V97M	exonic	ENSG00000164794.9	.	nonsynonymous SNV	ENSG00000164794.9:ENST00000524391.6:exon2:c.G289A:p.V97M	8q23.2	C3L-00589	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.112	T	T	T	0.180	0.323	0.831	1.820	T	T	T	T	T	T	2.500	22.400	0.992	D	N	-0.114	2.130	0.034	2.480	1.000	0.652	0.563	0.641	0.530	.	4.950	4.950	1.441	1.026	0.599	0.786	0.996	0.984	702	Potassium_channel_tetramerisation-type_BTB_domain;BTB/POZ_domain	.	.	.	KCNV1	452	1	1074	138	0.113861386138614	TRUE	TRUE
ENSG00000155897.10	.	BCM	GRCh38.p13	chr8	130814079	130814079	+	C	C	T	Missense_Mutation	SNP	ENST00000286355.10	exon14	c.G2903A	p.R968Q	exonic	ENSG00000155897.10	.	nonsynonymous SNV	ENSG00000155897.10:ENST00000286355.10:exon14:c.G2903A:p.R968Q	8q24.22	C3L-00589	9.068e-05	0	0	0	0.0002	0.0002	0	0	rs374456387	15.20	D	D	D	P	D	D	M	T	D	0.752	D	D	D	0.514	.	0.868	1.353	T	D	T	D	D	T	3.874	26.200	0.999	D	D	0.512	5.131	0.526	5.402	1.000	0.615	0.574	0.659	0.530	.	5.870	5.870	3.825	1.011	0.581	0.998	0.819	0.223	894	Adenylyl_cyclase_class-3/4/guanylyl_cyclase	.	.	ID=COSV53912398;OCCURENCE=1(breast),2(large_intestine),1(skin)	ADCY8	101	0	196	19	0.0883720930232558	TRUE	TRUE
ENSG00000169436.17	.	BCM	GRCh38.p13	chr8	138878263	138878263	+	C	C	T	Missense_Mutation	SNP	ENST00000303045.11	exon3	c.G145A	p.V49M	exonic	ENSG00000169436.17	.	nonsynonymous SNV	ENSG00000169436.17:ENST00000303045.11:exon3:c.G145A:p.V49M	8q24.23	C3L-00589	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	U	D	M	D	N	0.605	D	D	D	0.598	0.642	0.612	0.084	T	T	D	D	D	D	3.582	25.000	0.999	D	D	0.657	6.560	0.656	7.004	1.000	0.615	0.574	0.659	0.563	.	5.190	5.190	5.977	1.026	0.599	1.000	1.000	0.999	972	von_Willebrand_factor,_type_A	.	.	ID=COSV57351511;OCCURENCE=1(lung)	COL22A1	67	0	208	20	0.087719298245614	TRUE	TRUE
ENSG00000171505.5	.	BCM	GRCh38.p13	chr9	122526561	122526561	+	C	C	T	Missense_Mutation	SNP	ENST00000304880.2	exon1	c.G733A	p.V245I	exonic	ENSG00000171505.5	.	nonsynonymous SNV	ENSG00000171505.5:ENST00000304880.2:exon1:c.G733A:p.V245I	9q33.2	C3L-00589	0.0012	9.645e-05	0.0031	0.0003	0.0030	0.0011	0.0069	0.0005	rs151154516	3.20	D	D	B	B	U	N	M	T	N	0.056	T	T	T	0.061	.	0.128	0.031	T	T	T	T	T	T	0.721	8.647	0.979	N	N	-0.672	0.860	-0.722	0.868	0.973	0.487	0.563	0.574	0.542	.	3.750	2.850	0.314	-0.391	-1.022	0.000	0.930	0.709	894	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV59195879;OCCURENCE=1(breast),1(large_intestine),1(ovary),1(haematopoietic_and_lymphoid_tissue),1(upper_aerodigestive_tract),1(endometrium)	OR1N1	57	0	120	11	0.083969465648855	TRUE	TRUE
ENSG00000198915.11	.	BCM	GRCh38.p13	chr10	43200738	43200738	+	C	C	T	Missense_Mutation	SNP	ENST00000395809.5	exon5	c.G610A	p.A204T	exonic	ENSG00000198915.11	.	nonsynonymous SNV	ENSG00000198915.11:ENST00000395809.5:exon5:c.G610A:p.A204T	10q11.21	C3L-00589	5.81e-05	0	0.0002	0	0	3.028e-05	0	0.0002	rs767084570	0.20	T	T	B	B	N	N	N	T	N	0.068	T	T	T	0.029	0.304	0.196	0.705	T	T	T	T	T	T	0.283	4.093	0.944	N	N	-0.653	0.893	-0.702	0.897	0.997	0.719	0.634	0.723	0.568	.	5.040	0.319	-0.466	-1.411	-1.556	0.000	0.031	0.123	851	.	.	.	ID=COSV65666676;OCCURENCE=1(cervix),1(large_intestine)	RASGEF1A	263	0	710	58	0.0755208333333333	TRUE	TRUE
ENSG00000266200.6	.	BCM	GRCh38.p13	chr10	116638428	116638428	+	A	A	G	Missense_Mutation	SNP	ENST00000591655.3	exon11	c.A1126G	p.R376G	exonic	ENSG00000266200.6	.	nonsynonymous SNV	ENSG00000266200.6:ENST00000591655.3:exon11:c.A1126G:p.R376G	10q25.3	C3L-00589	.	.	.	.	.	.	.	.	.	1.15	.	.	B	B	N	N	.	.	.	0.225	T	T	T	0.222	0.552	0.161	.	T	T	D	T	T	T	1.458	15.470	0.929	N	N	-0.681	0.844	-0.657	0.963	0.014	0.075	0.063	0.079	0.057	.	5.480	1.690	2.146	0.230	0.756	0.037	0.389	0.587	620	PLAT/LH2_domain	.	.	.	PNLIPRP2	83	0	59	20	0.253164556962025	TRUE	TRUE
ENSG00000179241.13	.	BCM	GRCh38.p13	chr11	36081721	36081721	+	C	C	T	Missense_Mutation	SNP	ENST00000315571.6	exon3	c.C262T	p.R88C	exonic	ENSG00000179241.13	.	nonsynonymous SNV	ENSG00000179241.13:ENST00000315571.6:exon3:c.C262T:p.R88C	11p13	C3L-00589	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.892	D	D	D	0.872	0.668	0.936	0.873	D	D	D	D	D	D	4.381	31	0.999	D	D	0.865	10.178	0.839	11.397	1.000	0.707	0.588	0.644	0.714	.	5.950	5.950	5.657	1.026	0.599	1.000	0.997	0.921	949	Low-density_lipoprotein_(LDL)_receptor_class_A,_conserved_site	.	.	ID=COSV100214374;OCCURENCE=1(upper_aerodigestive_tract)	LDLRAD3	291	0	452	33	0.0680412371134021	TRUE	TRUE
ENSG00000197891.12	.	BCM	GRCh38.p13	chr11	64593506	64593506	+	G	G	A	Missense_Mutation	SNP	ENST00000377574.6	exon3	c.G608A	p.R203H	exonic	ENSG00000197891.12	.	nonsynonymous SNV	ENSG00000197891.12:ENST00000377574.6:exon3:c.G608A:p.R203H	11q13.1	C3L-00589	3.306e-05	0	0.0002	0	0	1.505e-05	0	6.056e-05	rs141975942	18.19	D	D	D	D	D	D	H	T	D	0.649	D	D	D	0.806	.	0.923	0.972	.	D	D	D	D	D	3.839	26.000	1.000	D	D	0.767	8.165	0.640	6.766	1.000	0.403	0.547	0.578	0.613	.	4.810	4.810	6.233	1.174	0.676	1.000	0.811	0.079	510	Major_facilitator_superfamily_domain	.	.	.	SLC22A12	458	1	929	94	0.0918866080156403	TRUE	NA
ENSG00000165323.15	.	BCM	GRCh38.p13	chr11	92799797	92799797	+	G	G	A	Missense_Mutation	SNP	ENST00000409404.6	exon9	c.G6784A	p.D2262N	exonic	ENSG00000165323.15	.	nonsynonymous SNV	ENSG00000165323.15:ENST00000409404.6:exon9:c.G6784A:p.D2262N	11q14.3	C3L-00589	4.432e-05	0	0	0	0	7.974e-05	0	0	rs761353192	8.15	D	.	.	.	.	D	M	T	D	0.600	T	T	D	0.622	0.919	0.668	.	T	T	T	T	D	.	3.400	24.400	0.998	D	D	0.803	8.834	0.755	8.913	1.000	0.615	0.574	0.659	0.564	.	5.940	5.940	8.052	1.176	0.676	1.000	0.466	0.184	906	Cadherin-like	.	.	ID=COSV53076041;OCCURENCE=1(large_intestine),1(bone)	FAT3	162	0	164	17	0.0939226519337017	TRUE	TRUE
ENSG00000170209.5	.	BCM	GRCh38.p13	chr11	113400215	113400215	+	C	C	T	Missense_Mutation	SNP	ENST00000303941.4	exon8	c.C2246T	p.P749L	exonic	ENSG00000170209.5	.	nonsynonymous SNV	ENSG00000170209.5:ENST00000303941.4:exon8:c.C2246T:p.P749L	11q23.2	C3L-00589	5.17e-05	0	0	0	0	0	0	0.0001	rs775477797	1.20	T	T	B	B	N	N	L	T	N	0.169	T	T	D	0.144	0.316	0.312	0.062	T	T	T	T	T	T	0.418	5.625	0.545	N	N	-1.555	0.066	-1.553	0.089	0.031	0.516	0.610	0.547	0.564	.	4.780	0.726	0.772	-4.010	-3.004	0.001	0.000	0.001	857	.	.	.	.	ANKK1	113	0	269	25	0.0850340136054422	TRUE	NA
ENSG00000166736.11	.	BCM	GRCh38.p13	chr11	113986533	113986533	+	C	C	T	Missense_Mutation	SNP	ENST00000504030.6	exon7	c.C721T	p.R241W	exonic	ENSG00000166736.11	.	nonsynonymous SNV	ENSG00000166736.11:ENST00000504030.6:exon7:c.C721T:p.R241W	11q23.2	C3L-00589	4.144e-05	0.0002	0.0002	0	0	1.509e-05	0	0	rs369114231	15.18	D	T	.	.	D	D	M	T	D	0.886	D	D	D	0.798	.	0.891	0.458	T	D	D	D	D	D	3.531	24.800	0.999	D	D	0.531	5.285	0.398	4.345	0.004	0.615	0.590	0.659	0.542	.	5.000	3.080	0.500	-0.309	0.599	0.993	0.927	0.945	934	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	.	HTR3A	295	0	623	41	0.0617469879518072	TRUE	NA
ENSG00000149403.13	.	BCM	GRCh38.p13	chr11	120956785	120956785	+	C	C	T	Missense_Mutation	SNP	ENST00000527524.8	exon16	c.C1706T	p.T569M	exonic	ENSG00000149403.13	.	nonsynonymous SNV	ENSG00000149403.13:ENST00000527524.8:exon16:c.C1706T:p.T569M	11q23.3	C3L-00589	4.38e-05	0	0	0	0	4.627e-05	0	0.0002	rs373630796	13.20	D	D	D	D	D	D	L	T	D	0.717	T	T	D	0.316	.	0.335	1.439	T	D	T	T	D	D	3.750	25.600	0.999	D	D	0.666	6.669	0.635	6.690	0.991	0.560	0.624	0.468	0.564	.	4.960	4.960	2.787	1.026	0.599	0.991	0.984	0.996	581	Ionotropic_glutamate_receptor	.	.	ID=COSV70806102;OCCURENCE=1(stomach),1(prostate)	GRIK4	49	0	105	23	0.1796875	TRUE	TRUE
ENSG00000236981.1	.	BCM	GRCh38.p13	chr11	124023607	124023607	+	T	T	C	Missense_Mutation	SNP	ENST00000375024.1	exon1	c.T595C	p.F199L	exonic	ENSG00000236981.1	.	nonsynonymous SNV	ENSG00000236981.1:ENST00000375024.1:exon1:c.T595C:p.F199L	11q24.2	C3L-00589	.	.	.	.	.	.	.	.	.	2.20	T	T	D	D	N	N	L	T	N	0.057	T	T	T	0.169	0.324	0.293	1.072	T	T	T	T	T	T	2.302	21.600	0.997	N	N	-0.065	2.287	-0.157	1.893	0.000	0.487	0.574	0.547	0.530	.	3.480	3.480	0.105	1.115	0.661	0.003	0.219	0.009	810	GPCR,_rhodopsin-like,_7TM	.	.	.	OR10G9	317	0	355	79	0.182027649769585	NA	TRUE
ENSG00000151490.15	.	BCM	GRCh38.p13	chr12	15499529	15499529	+	C	C	G	Missense_Mutation	SNP	ENST00000281171.9	exon4	c.C596G	p.T199S	exonic	ENSG00000151490.15	.	nonsynonymous SNV	ENSG00000151490.15:ENST00000281171.9:exon4:c.C596G:p.T199S	12p12.3	C3L-00589	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	T	N	0.269	T	T	T	0.040	0.196	0.190	0.248	T	T	T	T	D	T	1.679	16.890	0.961	D	N	-0.500	1.177	-0.279	1.608	0.421	0.554	0.574	0.618	0.542	.	4.990	3.150	3.026	1.008	0.599	0.995	1.000	1.000	803	.	.	.	.	PTPRO	340	0	292	26	0.0817610062893082	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-00589	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	327	1	240	65	0.213114754098361	TRUE	TRUE
ENSG00000184613.10	.	BCM	GRCh38.p13	chr12	44610880	44610880	+	G	G	A	Missense_Mutation	SNP	ENST00000429094.6	exon14	c.C1535T	p.P512L	exonic	ENSG00000184613.10	.	nonsynonymous SNV	ENSG00000184613.10:ENST00000429094.6:exon14:c.C1535T:p.P512L	12q12	C3L-00589	0.0004	9.621e-05	0.0008	0	0	0.0006	0	0	rs144387740	12.20	T	T	B	B	D	D	L	D	D	0.467	D	D	D	0.667	.	0.361	0.160	T	D	T	D	T	D	2.680	22.800	0.994	D	D	0.263	3.592	0.374	4.181	0.782	0.693	0.588	0.659	0.564	.	4.970	4.970	7.540	1.176	0.674	1.000	0.995	0.964	702	EGF-like,_conserved_site;EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	NELL2	173	0	233	15	0.0604838709677419	TRUE	NA
ENSG00000131951.11	.	BCM	GRCh38.p13	chr14	60053111	60053111	+	C	C	G	Missense_Mutation	SNP	ENST00000445360.5	exon30	c.C4037G	p.P1346R	exonic	ENSG00000131951.11	.	nonsynonymous SNV	ENSG00000131951.11:ENST00000445360.5:exon30:c.C4037G:p.P1346R	14q23.1	C3L-00589	.	.	.	.	.	.	.	.	.	7.12	D	D	.	.	.	D	.	T	D	0.644	.	.	D	.	.	0.393	.	.	T	T	T	.	T	3.710	25.400	0.998	D	D	.	.	.	.	1.000	0.554	0.574	0.618	0.542	.	5.150	5.150	4.199	1.026	0.599	1.000	1.000	0.999	567	.	.	.	.	LRRC9	132	0	104	13	0.111111111111111	TRUE	TRUE
ENSG00000100731.16	.	BCM	GRCh38.p13	chr14	70969087	70969087	+	G	G	T	Missense_Mutation	SNP	ENST00000304743.7	exon5	c.G581T	p.C194F	exonic	ENSG00000100731.16	.	nonsynonymous SNV	ENSG00000100731.16:ENST00000304743.7:exon5:c.G581T:p.C194F	14q24.2	C3L-00589	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	N	0.768	T	T	D	0.316	0.237	0.043	0.644	D	T	D	D	D	D	3.458	24.600	0.952	D	D	0.482	4.899	0.554	5.686	1.000	0.745	0.732	0.744	0.728	.	5.580	5.580	5.510	1.176	0.616	1.000	1.000	0.997	768	.	.	.	.	PCNX1	119	0	126	8	0.0597014925373134	TRUE	TRUE
ENSG00000198668.13	.	BCM	GRCh38.p13	chr14	90401345	90401345	+	G	G	A	Missense_Mutation	SNP	ENST00000356978.9	exon3	c.G121A	p.G41S	exonic	ENSG00000198668.13	.	nonsynonymous SNV	ENSG00000198668.13:ENST00000356978.9:exon3:c.G121A:p.G41S	14q32.11	C3L-00589	.	.	.	.	.	.	.	.	.	15.17	.	D	D	P	U	D	.	D	D	0.832	D	D	D	0.808	0.531	0.991	3.061	D	.	D	D	D	D	4.347	30	0.997	D	D	0.744	7.786	0.730	8.363	1.000	0.646	0.696	0.702	0.723	.	4.620	4.620	10.003	1.161	0.676	1.000	1.000	0.999	804	EF-hand_domain	.	.	.	CALM1	221	0	200	29	0.126637554585153	TRUE	TRUE
ENSG00000133958.13	.	BCM	GRCh38.p13	chr14	93617263	93617263	+	C	C	T	Missense_Mutation	SNP	ENST00000393151.6	exon28	c.C4183T	p.R1395W	exonic	ENSG00000133958.13	.	nonsynonymous SNV	ENSG00000133958.13:ENST00000393151.6:exon28:c.C4183T:p.R1395W	14q32.12	C3L-00589	8.254e-06	0	0	0	0	0	0	6.064e-05	rs769549721	14.17	D	D	.	.	D	D	M	T	D	0.925	T	T	D	0.403	0.680	0.469	1.093	D	D	D	D	D	.	3.746	25.600	0.999	D	D	0.423	4.489	0.371	4.160	0.002	0.554	0.590	0.602	0.564	.	5.520	3.640	0.649	0.074	0.549	0.976	0.995	0.996	794	.	.	.	ID=COSV56378995;OCCURENCE=1(large_intestine),1(skin),2(lung)	UNC79	154	0	206	50	0.1953125	TRUE	TRUE
ENSG00000185024.17	.	BCM	GRCh38.p13	chr14	105220106	105220106	+	A	A	T	Missense_Mutation	SNP	ENST00000547530.7	exon12	c.T1340A	p.L447Q	exonic	ENSG00000185024.17	.	nonsynonymous SNV	ENSG00000185024.17:ENST00000547530.7:exon12:c.T1340A:p.L447Q	14q32.33	C3L-00589	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	M	.	D	0.676	T	T	D	0.310	0.329	0.611	.	T	T	D	D	D	D	4.024	27.100	0.996	D	D	0.640	6.357	0.590	6.101	1.000	0.707	0.725	0.723	0.636	.	5.600	5.600	6.484	1.202	0.751	1.000	0.973	0.747	946	.	.	.	.	BRF1	200	0	458	32	0.0653061224489796	TRUE	TRUE
ENSG00000159433.12	.	BCM	GRCh38.p13	chr15	42689773	42689773	+	T	T	A	Missense_Mutation	SNP	ENST00000290607.12	exon23	c.T8195A	p.V2732D	exonic	ENSG00000159433.12	.	nonsynonymous SNV	ENSG00000159433.12:ENST00000290607.12:exon23:c.T8195A:p.V2732D	15q15.2	C3L-00589	.	.	.	.	.	.	.	.	.	0.17	T	.	.	.	N	N	N	T	N	0.075	T	T	T	0.112	0.191	0.102	.	T	T	T	T	T	T	-0.316	0.289	0.619	N	N	-1.123	0.287	-1.168	0.310	0.996	0.651	0.709	0.659	0.528	.	5.790	-0.697	-0.101	0.200	-0.115	0.000	0.050	0.175	91	.	.	.	.	STARD9	208	0	307	69	0.183510638297872	TRUE	TRUE
ENSG00000197599.12	.	BCM	GRCh38.p13	chr16	1443911	1443911	+	G	G	A	Missense_Mutation	SNP	ENST00000389176.3	exon2	c.C109T	p.P37S	exonic	ENSG00000197599.12	.	nonsynonymous SNV	ENSG00000197599.12:ENST00000389176.3:exon2:c.C109T:p.P37S	16p13.3	C3L-00589	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	D	L	.	N	0.091	T	T	T	0.022	.	0.014	0.000	T	T	T	T	T	T	0.465	6.138	0.792	N	N	-0.823	0.621	-0.824	0.725	0.504	0.581	0.551	0.578	0.605	.	3.920	2.950	0.194	0.162	0.665	0.005	0.003	0.030	783	.	.	.	.	CCDC154	469	0	1240	102	0.0760059612518629	TRUE	NA
ENSG00000167191.12	.	BCM	GRCh38.p13	chr16	19872176	19872176	+	C	C	T	Missense_Mutation	SNP	ENST00000300571.7	exon2	c.G670A	p.G224S	exonic	ENSG00000167191.12	.	nonsynonymous SNV	ENSG00000167191.12:ENST00000300571.7:exon2:c.G670A:p.G224S	16p12.3	C3L-00589	7.418e-05	0	0.0002	0	0	8.993e-05	0	6.056e-05	rs148789431	14.20	D	D	D	D	D	D	M	T	D	0.889	T	T	T	0.575	.	0.439	1.245	T	D	T	D	D	D	3.810	25.900	0.999	D	D	0.837	9.542	0.819	10.699	1.000	0.707	0.588	0.725	0.714	.	5.440	5.440	7.823	1.026	0.599	1.000	0.998	0.968	702	GPCR_family_3,_C-terminal	.	.	ID=COSV100315220;OCCURENCE=1(stomach)	GPRC5B	464	0	959	83	0.0796545105566219	TRUE	NA
ENSG00000280789.2	.	BCM	GRCh38.p13	chr16	29819632	29819632	+	G	G	A	Missense_Mutation	SNP	ENST00000320330.8	exon3	c.G643A	p.E215K	exonic	ENSG00000280789.2;ENSG00000281348.1	.	nonsynonymous SNV	ENSG00000280789.2:ENST00000320330.8:exon3:c.G643A:p.E215K	16p11.2	C3L-00589	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	L	.	N	0.747	T	T	T	0.240	0.211	0.531	.	D	D	D	D	D	D	4.602	32	0.999	D	D	0.826	9.305	0.825	10.910	1.000	0.722	0.686	0.696	0.735	.	5.820	5.820	8.652	1.176	0.676	1.000	1.000	1.000	246	.	.	.	.	PAGR1	284	0	535	30	0.0530973451327434	TRUE	TRUE
ENSG00000177238.14	.	BCM	GRCh38.p13	chr16	31214907	31214907	+	C	C	T	Nonsense_Mutation	SNP	ENST00000322122.8	exon2	c.C169T	p.Q57X	exonic	ENSG00000177238.14	.	stopgain	ENSG00000177238.14:ENST00000322122.8:exon2:c.C169T:p.Q57X	16p11.2	C3L-00589	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.738	.	.	.	.	.	.	.	.	.	D	D	.	.	5.750	34	0.997	D	N	0.812	9.010	0.609	6.342	1.000	0.598	0.541	0.504	0.639	.	5.030	5.030	0.669	0.966	0.530	0.968	0.091	0.022	184	Zinc_finger,_RING-type	.	.	.	TRIM72	147	0	467	123	0.208474576271186	TRUE	NA
ENSG00000140807.7	.	BCM	GRCh38.p13	chr16	50633305	50633305	+	G	G	A	Missense_Mutation	SNP	ENST00000268459.6	exon10	c.G937A	p.V313M	exonic	ENSG00000140807.7	.	nonsynonymous SNV	ENSG00000140807.7:ENST00000268459.6:exon10:c.G937A:p.V313M	16q12.1	C3L-00589	0.0007	0	0.0066	0	0	7.493e-05	0	0	rs142902078	2.20	T	T	B	B	N	N	N	T	N	0.029	T	T	D	0.035	.	0.162	0.278	T	T	T	T	T	T	1.192	13.570	0.992	D	N	-0.508	1.160	-0.372	1.422	0.261	0.615	0.588	0.659	0.613	.	4.440	2.460	1.356	0.189	0.618	0.248	0.975	0.980	814	.	.	.	ID=COSV51694577;OCCURENCE=1(stomach),1(urinary_tract)	NKD1	224	0	523	29	0.052536231884058	TRUE	TRUE
ENSG00000157423.18	.	BCM	GRCh38.p13	chr16	70807755	70807755	+	C	C	T	Missense_Mutation	SNP	ENST00000393567.7	exon86	c.G15191A	p.R5064H	exonic	ENSG00000157423.18	.	nonsynonymous SNV	ENSG00000157423.18:ENST00000393567.7:exon86:c.G15191A:p.R5064H	16q22.2	C3L-00589	0.0005	0	0.0003	0	0	0.0005	0.0022	0.0008	rs183874188	3.16	D	.	.	.	U	N	M	T	D	0.410	T	T	T	0.147	.	0.185	.	T	T	T	T	T	.	3.170	23.800	0.998	N	N	0.455	4.701	0.383	4.242	1.000	0.447	0.563	0.563	0.613	.	6.160	5.140	2.079	1.026	0.599	0.989	0.016	0.016	467	.	.	.	ID=COSV66637747;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue),1(stomach),1(prostate)	HYDIN	391	2	648	43	0.0622286541244573	TRUE	TRUE
ENSG00000129910.8	.	BCM	GRCh38.p13	chr16	89194941	89194941	+	C	C	T	Missense_Mutation	SNP	ENST00000289746.3	exon14	c.C2231T	p.S744L	exonic	ENSG00000129910.8	.	nonsynonymous SNV	ENSG00000129910.8:ENST00000289746.3:exon14:c.C2231T:p.S744L	16q24.3	C3L-00589	.	.	.	.	.	.	.	.	rs145092759	19.20	D	D	D	D	D	D	H	D	D	0.725	D	D	D	0.734	0.855	0.933	0.234	T	D	D	D	D	D	3.508	24.700	0.998	D	D	0.603	5.957	0.405	4.393	1.000	0.646	0.547	0.645	0.568	.	4.930	4.930	4.911	0.900	0.599	1.000	0.003	0.002	819	Cadherin,_cytoplasmic_domain	.	.	ID=COSV104613639;OCCURENCE=1(skin)	CDH15	307	0	791	74	0.0855491329479769	TRUE	NA
ENSG00000213859.6	.	BCM	GRCh38.p13	chr17	7353427	7353427	+	G	G	A	Missense_Mutation	SNP	ENST00000576980.2	exon1	c.G485A	p.R162H	exonic	ENSG00000213859.6	.	nonsynonymous SNV	ENSG00000213859.6:ENST00000576980.2:exon1:c.G485A:p.R162H	17p13.1	C3L-00589	.	.	.	.	.	.	.	.	rs865964999	3.16	.	.	B	B	U	N	N	.	.	.	T	T	D	0.059	0.329	0.754	0.807	T	T	T	T	T	T	1.536	15.970	0.996	D	D	-0.341	1.515	-0.178	1.838	1.000	0.653	0.628	0.676	0.568	.	5.280	3.290	2.117	1.176	0.676	0.029	0.056	0.147	205	.	.	.	ID=COSV50134200;OCCURENCE=1(large_intestine),1(prostate)	KCTD11	140	0	251	22	0.0805860805860806	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675148	7675148	+	G	G	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.C464A	p.T155N	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.C464A:p.T155N	17p13.1	C3L-00589	.	.	.	.	.	.	.	.	rs786202752	12.20	D	D	P	P	N	N	M	D	N	0.855	D	D	D	0.548	0.894	0.871	1.482	T	D	D	D	D	D	1.270	14.170	0.779	N	N	-1.028	0.375	-1.191	0.290	0.623	0.722	0.698	0.698	0.735	.	5.470	-0.466	1.197	-0.758	-1.043	0.148	0.001	0.023	434	p53,_DNA-binding_domain	.	.	ID=COSV52711720;OCCURENCE=3(breast),2(liver),9(oesophagus),3(large_intestine),7(central_nervous_system),1(pleura),2(ovary),1(haematopoietic_and_lymphoid_tissue),2(soft_tissue),3(lung),9(upper_aerodigestive_tract)	TP53	278	0	471	123	0.207070707070707	TRUE	TRUE
ENSG00000276231.5	.	BCM	GRCh38.p13	chr17	8837820	8837820	+	T	T	A	Missense_Mutation	SNP	ENST00000619866.5	exon5	c.A241T	p.M81L	exonic	ENSG00000276231.5	.	nonsynonymous SNV	ENSG00000276231.5:ENST00000619866.5:exon5:c.A241T:p.M81L	17p13.1	C3L-00589	.	.	.	.	.	.	.	.	.	4.11	.	T	B	B	.	.	.	.	.	0.320	.	.	T	.	.	0.522	.	T	T	D	D	.	T	2.563	22.600	0.936	D	D	.	.	.	.	1.000	0.284	0.279	0.076	0.057	.	3.700	3.700	3.360	1.130	0.665	1.000	0.999	0.970	914	.	.	.	.	PIK3R6	170	0	242	30	0.110294117647059	TRUE	TRUE
ENSG00000007237.18	.	BCM	GRCh38.p13	chr17	10198306	10198306	+	T	T	C	Missense_Mutation	SNP	ENST00000432992.6	exon1	c.A85G	p.I29V	exonic	ENSG00000007237.18	.	nonsynonymous SNV	ENSG00000007237.18:ENST00000432992.6:exon1:c.A85G:p.I29V	17p13.1	C3L-00589	.	.	.	.	.	.	.	.	.	5.18	.	T	B	B	N	D	L	T	.	0.077	T	T	D	0.036	0.587	0.528	1.216	D	T	T	T	T	D	2.030	19.480	0.936	D	N	-0.628	0.938	-0.562	1.105	1.000	0.685	0.476	0.674	0.563	.	3.480	-0.740	1.212	0.071	0.648	0.854	0.970	0.955	866	SH3_domain	.	.	.	GAS7	466	0	965	100	0.0938967136150235	TRUE	TRUE
ENSG00000131242.18	.	BCM	GRCh38.p13	chr17	31528462	31528462	+	G	G	T	Missense_Mutation	SNP	ENST00000621161.5	exon12	c.G1413T	p.E471D	exonic	ENSG00000131242.18	.	nonsynonymous SNV	ENSG00000131242.18:ENST00000621161.5:exon12:c.G1413T:p.E471D	17q11.2	C3L-00589	.	.	.	.	.	.	.	.	.	13.17	.	D	D	D	D	D	M	.	.	0.809	T	T	D	0.186	0.097	0.355	.	T	T	D	D	D	D	4.117	27.900	0.974	D	D	0.816	9.106	0.805	10.270	1.000	0.707	0.725	0.725	0.530	.	5.810	5.810	6.546	1.172	0.672	1.000	0.999	0.985	918	.	.	.	.	RAB11FIP4	204	0	429	34	0.0734341252699784	TRUE	TRUE
ENSG00000167914.12	.	BCM	GRCh38.p13	chr17	39965863	39965863	+	C	C	T	Missense_Mutation	SNP	ENST00000301659.9	exon2	c.C176T	p.T59M	exonic	ENSG00000167914.12	.	nonsynonymous SNV	ENSG00000167914.12:ENST00000301659.9:exon2:c.C176T:p.T59M	17q21.1	C3L-00589	3.775e-05	0	0	0	0	7.988e-05	0	0	rs754816059	4.20	D	D	D	P	N	N	L	T	D	0.500	T	T	T	0.205	0.805	0.400	0.394	T	T	T	T	T	T	2.804	23.000	0.887	N	N	0.391	4.287	0.318	3.825	0.736	0.500	0.590	0.624	0.542	.	5.510	5.510	1.104	1.026	0.599	0.834	0.953	0.814	318	.	.	.	ID=COSV56977327;OCCURENCE=2(liver)	GSDMA	247	0	1631	96	0.0555877243775333	TRUE	TRUE
ENSG00000131746.13	.	BCM	GRCh38.p13	chr17	40477604	40477604	+	T	T	A	Missense_Mutation	SNP	ENST00000254051.11	exon13	c.A2132T	p.D711V	exonic	ENSG00000131746.13	.	nonsynonymous SNV	ENSG00000131746.13:ENST00000254051.11:exon13:c.A2132T:p.D711V	17q21.2	C3L-00589	.	.	.	.	.	.	.	.	.	6.20	D	D	P	P	N	D	M	T	D	0.196	T	T	T	0.095	0.564	0.477	0.584	T	T	T	T	D	T	2.707	22.800	0.991	N	N	-0.100	2.175	-0.187	1.818	1.000	0.428	0.547	0.547	0.613	.	5.270	4.160	0.316	1.138	0.665	0.011	0.049	0.111	284	PTB/PI_domain	.	.	.	TNS4	159	0	299	27	0.0828220858895705	TRUE	TRUE
ENSG00000108821.14	.	BCM	GRCh38.p13	chr17	50195614	50195614	+	G	G	A	Missense_Mutation	SNP	ENST00000225964.10	exon17	c.C1108T	p.R370C	exonic	ENSG00000108821.14	.	nonsynonymous SNV	ENSG00000108821.14:ENST00000225964.10:exon17:c.C1108T:p.R370C	17q21.33	C3L-00589	8.289e-06	0	0	0	0	0	0	6.058e-05	rs758897245	14.15	D	D	.	.	D	D	.	D	D	0.833	D	D	D	0.897	0.718	0.979	0.765	T	.	D	D	D	.	4.612	32	0.998	D	D	0.873	10.377	0.816	10.605	1.000	0.707	0.616	0.725	0.639	.	5.610	5.610	2.935	1.176	0.676	1.000	1.000	1.000	893	.	.	.	ID=COSV56802381;OCCURENCE=3(large_intestine),1(stomach)	COL1A1	307	0	700	60	0.0789473684210526	TRUE	TRUE
ENSG00000168646.13	.	BCM	GRCh38.p13	chr17	65557843	65557843	+	-	NA	CC	Frame_Shift_Ins	INS	ENST00000307078.10	exon2	c.777_778insGG	p.S260Gfs*3	exonic	ENSG00000168646.13	.	frameshift insertion	ENSG00000168646.13:ENST00000307078.10:exon2:c.777_778insGG:p.S260Gfs*3	17q24.1	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AXIN2	NA	NA	NA	NA	NA	NA	NA
ENSG00000152217.19	.	BCM	GRCh38.p13	chr18	44951139	44951139	+	C	C	T	Missense_Mutation	SNP	ENST00000649279.2	exon4	c.C1799T	p.T600M	exonic	ENSG00000152217.19	.	nonsynonymous SNV	ENSG00000152217.19:ENST00000649279.2:exon4:c.C1799T:p.T600M	18q12.3	C3L-00589	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	N	0.832	T	T	D	0.364	0.196	0.534	0.932	D	T	D	D	D	D	3.552	24.900	0.998	D	D	0.734	7.623	0.767	9.210	1.000	0.563	0.654	0.602	0.564	.	6.070	6.070	7.542	1.026	0.599	1.000	0.636	0.689	899	.	.	.	ID=COSV56322690;OCCURENCE=1(stomach)	SETBP1	293	0	326	35	0.0969529085872576	TRUE	TRUE
ENSG00000181588.16	.	BCM	GRCh38.p13	chr19	1556441	1556441	+	C	C	T	Missense_Mutation	SNP	ENST00000402693.4	exon2	c.G1078A	p.D360N	exonic	ENSG00000181588.16	.	nonsynonymous SNV	ENSG00000181588.16:ENST00000402693.4:exon2:c.G1078A:p.D360N	19p13.3	C3L-00589	.	.	.	.	.	.	.	.	.	11.20	D	D	P	P	U	D	M	T	D	0.733	T	T	D	0.379	0.671	0.610	.	D	T	T	T	D	D	3.753	25.600	0.999	D	D	0.516	5.161	0.521	5.352	1.000	0.707	0.634	0.723	0.714	.	4.730	4.730	7.363	0.947	0.452	1.000	0.998	0.863	976	.	.	.	ID=COSV101183472;OCCURENCE=1(stomach)	MEX3D	167	0	442	82	0.156488549618321	TRUE	TRUE
ENSG00000142303.14	.	BCM	GRCh38.p13	chr19	8600969	8600969	+	G	G	A	Missense_Mutation	SNP	ENST00000597188.6	exon6	c.C769T	p.R257C	exonic	ENSG00000142303.14	.	nonsynonymous SNV	ENSG00000142303.14:ENST00000597188.6:exon6:c.C769T:p.R257C	19p13.2	C3L-00589	.	.	.	.	.	.	.	.	.	15.16	D	D	.	.	D	D	.	D	D	0.816	D	D	D	0.848	0.632	0.905	1.610	T	.	D	D	D	D	4.379	31	0.999	D	D	0.741	7.727	0.704	7.836	0.905	0.617	0.574	0.786	0.655	.	5.190	5.190	6.275	1.121	0.644	1.000	0.905	0.935	835	Peptidase_M12B,_ADAM/reprolysin	.	.	ID=COSV54357422;OCCURENCE=1(large_intestine),1(endometrium)	ADAMTS10	372	0	838	84	0.0911062906724512	TRUE	TRUE
ENSG00000170929.6	.	BCM	GRCh38.p13	chr19	9094002	9094002	+	G	G	A	Missense_Mutation	SNP	ENST00000641627.1	exon2	c.G758A	p.G253E	exonic	ENSG00000170929.6	.	nonsynonymous SNV	ENSG00000170929.6:ENST00000641627.1:exon2:c.G758A:p.G253E	19p13.2	C3L-00589	.	.	.	.	.	.	.	.	.	8.20	D	D	D	D	D	N	M	T	D	0.370	T	T	T	0.216	0.572	0.697	0.202	T	T	T	T	D	T	3.042	23.500	0.998	N	N	0.417	4.453	0.200	3.183	0.000	0.487	0.574	0.574	0.564	.	3.710	3.710	0.106	0.839	0.663	0.000	0.864	0.830	970	GPCR,_rhodopsin-like,_7TM	.	.	.	OR1M1	257	1	379	22	0.0548628428927681	TRUE	NA
ENSG00000160111.13	.	BCM	GRCh38.p13	chr19	16993543	16993543	+	G	G	A	Missense_Mutation	SNP	ENST00000443236.6	exon12	c.C1139T	p.T380M	exonic	ENSG00000160111.13	.	nonsynonymous SNV	ENSG00000160111.13:ENST00000443236.6:exon12:c.C1139T:p.T380M	19p13.11	C3L-00589	8.293e-05	0	8.655e-05	0.0006	0	6.004e-05	0	0	rs183563770	1.17	T	T	.	.	N	N	.	T	N	0.234	T	T	T	0.023	.	0.347	0.195	T	T	T	T	T	T	0.983	11.410	0.759	D	N	-0.641	0.914	-0.618	1.019	0.001	0.651	0.547	0.651	0.613	.	3.040	0.744	1.588	0.035	-0.119	0.970	0.067	0.063	970	.	.	.	ID=COSV52237911;OCCURENCE=2(large_intestine),1(stomach)	CPAMD8	172	2	320	32	0.0909090909090909	NA	TRUE
ENSG00000213988.11	.	BCM	GRCh38.p13	chr19	20118726	20118726	+	A	A	C	Missense_Mutation	SNP	ENST00000418063.3	exon4	c.A1172C	p.H391P	exonic	ENSG00000213988.11	.	nonsynonymous SNV	ENSG00000213988.11:ENST00000418063.3:exon4:c.A1172C:p.H391P	19p12	C3L-00589	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	.	D	M	T	D	0.329	T	D	T	0.192	0.715	0.405	0.003	T	T	T	T	D	T	2.018	19.400	0.853	N	N	0.096	2.871	-0.221	1.737	0.002	0.635	0.588	0.644	0.564	.	1.180	1.180	4.842	-0.357	-0.272	0.998	0.000	0.001	952	Zinc_finger_C2H2-type	.	.	.	ZNF90	229	4	201	21	0.0945945945945946	TRUE	TRUE
ENSG00000204519.11	.	BCM	GRCh38.p13	chr19	57687359	57687359	+	C	C	G	Missense_Mutation	SNP	ENST00000282296.10	exon3	c.C1084G	p.P362A	exonic	ENSG00000204519.11	.	nonsynonymous SNV	ENSG00000204519.11:ENST00000282296.10:exon3:c.C1084G:p.P362A	19q13.43	C3L-00589	.	.	.	.	.	.	.	.	.	3.17	.	D	P	B	.	N	M	T	.	0.201	T	T	T	0.067	0.400	0.276	0.130	T	T	T	T	D	T	1.122	12.980	0.928	N	N	-0.617	0.956	-0.844	0.696	0.047	0.672	0.654	0.702	0.636	.	2.580	0.266	0.718	0.031	0.599	0.000	0.009	0.007	976	Zinc_finger_C2H2-type	.	.	.	ZNF551	262	0	263	24	0.0836236933797909	TRUE	TRUE
ENSG00000101327.9	.	BCM	GRCh38.p13	chr20	1980454	1980454	+	G	G	A	Missense_Mutation	SNP	ENST00000217305.3	exon4	c.C634T	p.R212W	exonic	ENSG00000101327.9	.	nonsynonymous SNV	ENSG00000101327.9:ENST00000217305.3:exon4:c.C634T:p.R212W	20p13	C3L-00589	2.471e-05	0	8.637e-05	0	0	2.997e-05	0	0	rs201486601	18.20	D	D	D	D	D	A	M	D	D	0.972	D	D	D	0.715	.	0.981	0.225	T	D	D	D	D	D	3.405	24.400	0.999	D	N	0.171	3.177	-0.015	2.309	0.000	0.554	0.563	0.602	0.542	.	5.000	-3.040	0.681	0.186	0.618	1.000	0.990	0.997	871	.	.	.	ID=COSV54101259;OCCURENCE=1(breast),1(oesophagus),2(large_intestine),1(central_nervous_system),1(kidney),1(upper_aerodigestive_tract),1(endometrium)	PDYN	303	0	468	41	0.0805500982318271	TRUE	TRUE
ENSG00000172264.17	.	BCM	GRCh38.p13	chr20	14684894	14684894	+	G	G	-	Frame_Shift_Del	DEL	ENST00000217246.8	exon5	c.353delG	p.R118Lfs*3	exonic	ENSG00000172264.17	.	frameshift deletion	ENSG00000172264.17:ENST00000217246.8:exon5:c.353delG:p.R118Lfs*3	20p12.1	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MACROD2	272	0	255	27	0.0957446808510638	NA	TRUE
ENSG00000101004.15	.	BCM	GRCh38.p13	chr20	25479019	25479019	+	C	C	T	Missense_Mutation	SNP	ENST00000278886.11	exon16	c.G2105A	p.R702H	exonic	ENSG00000101004.15	.	nonsynonymous SNV	ENSG00000101004.15:ENST00000278886.11:exon16:c.G2105A:p.R702H	20p11.21	C3L-00589	.	.	.	.	.	.	.	.	rs917252420	0.20	T	T	B	B	N	N	N	T	N	0.060	T	T	T	0.026	0.107	0.085	0.130	T	T	T	T	T	T	-0.882	0.016	0.872	N	N	-1.877	0.016	-2.004	0.013	1.000	0.672	0.547	0.702	0.636	.	4.190	-8.380	-1.996	-0.754	-0.981	0.000	0.000	0.001	575	.	.	.	.	NINL	101	0	285	34	0.106583072100313	TRUE	NA
ENSG00000118702.9	.	BCM	GRCh38.p13	chr20	37256856	37256856	+	T	T	C	Missense_Mutation	SNP	ENST00000373614.6	exon2	c.A34G	p.T12A	exonic	ENSG00000118702.9	.	nonsynonymous SNV	ENSG00000118702.9:ENST00000373614.6:exon2:c.A34G:p.T12A	20q11.23	C3L-00589	.	.	.	.	.	.	.	.	.	4.20	D	T	D	P	N	N	M	T	N	0.194	T	T	T	0.134	0.244	0.382	0.369	T	T	T	T	D	T	2.519	22.500	0.992	N	N	-0.239	1.770	-0.309	1.546	0.000	0.554	0.590	0.602	0.530	.	4.970	-1.530	0.264	-0.564	-1.509	0.997	0.987	0.812	839	.	.	.	.	GHRH	166	0	311	34	0.0985507246376812	TRUE	TRUE
ENSG00000124134.9	.	BCM	GRCh38.p13	chr20	45098402	45098402	+	G	G	A	Missense_Mutation	SNP	ENST00000537075.3	exon3	c.C370T	p.H124Y	exonic	ENSG00000124134.9	.	nonsynonymous SNV	ENSG00000124134.9:ENST00000537075.3:exon3:c.C370T:p.H124Y	20q13.12	C3L-00589	.	.	.	.	.	.	.	.	.	17.20	D	D	P	P	D	D	M	T	D	0.700	D	D	D	0.859	0.727	0.882	.	D	D	D	D	D	D	4.144	28.100	0.997	D	D	0.729	7.544	0.706	7.859	1.000	0.437	0.616	0.504	0.604	.	4.720	4.720	9.668	1.176	0.674	1.000	1.000	0.996	748	Potassium_channel_tetramerisation-type_BTB_domain;BTB/POZ_domain	.	.	.	KCNS1	177	0	379	44	0.104018912529551	TRUE	TRUE
ENSG00000101096.20	.	BCM	GRCh38.p13	chr20	51523306	51523306	+	G	G	A	Missense_Mutation	SNP	ENST00000396009.7	exon2	c.C935T	p.T312M	exonic	ENSG00000101096.20	.	nonsynonymous SNV	ENSG00000101096.20:ENST00000396009.7:exon2:c.C935T:p.T312M	20q13.2	C3L-00589	.	.	.	.	.	.	.	.	rs376937921	4.20	D	D	P	B	N	N	L	T	D	0.321	T	T	T	0.114	.	0.274	0.603	T	T	T	T	T	D	2.080	19.860	0.992	N	N	-0.177	1.941	-0.251	1.668	1.000	0.707	0.725	0.578	0.636	.	5.570	3.580	2.662	1.176	0.618	0.115	0.876	0.966	969	.	.	.	ID=COSV65359138;OCCURENCE=1(stomach),1(skin),1(lung)	NFATC2	134	0	345	34	0.0897097625329815	TRUE	TRUE
ENSG00000142156.15	.	BCM	GRCh38.p13	chr21	46002034	46002034	+	G	G	A	Missense_Mutation	SNP	ENST00000361866.8	exon31	c.G2030A	p.R677H	exonic	ENSG00000142156.15	.	nonsynonymous SNV	ENSG00000142156.15:ENST00000361866.8:exon31:c.G2030A:p.R677H	21q22.3	C3L-00589	2.761e-05	0.0001	0	0.0001	0	0	0	6.611e-05	rs373731596	4.20	T	T	B	B	U	N	L	D	N	0.213	T	T	D	0.313	.	0.716	0.841	T	T	T	T	T	T	1.891	18.420	0.999	D	D	-0.221	1.819	-0.097	2.056	1.000	0.696	0.588	0.723	0.563	.	4.640	3.680	2.934	1.015	0.676	0.999	0.200	0.140	976	von_Willebrand_factor,_type_A	.	.	ID=COSV62613730;OCCURENCE=2(large_intestine),1(pancreas)	COL6A1	457	0	1046	110	0.0951557093425606	TRUE	TRUE
ENSG00000169184.6	.	BCM	GRCh38.p13	chr22	27797923	27797923	+	G	G	A	Missense_Mutation	SNP	ENST00000302326.5	exon1	c.C2621T	p.P874L	exonic	ENSG00000169184.6	.	nonsynonymous SNV	ENSG00000169184.6:ENST00000302326.5:exon1:c.C2621T:p.P874L	22q12.1	C3L-00589	.	.	.	.	.	.	.	.	.	8.20	D	D	B	B	N	D	L	T	D	0.127	T	T	D	0.131	0.312	0.681	.	D	T	T	T	D	T	3.219	23.900	0.995	D	N	-0.341	1.516	-0.212	1.758	1.000	0.765	0.588	0.674	0.767	.	4.100	4.100	3.708	1.101	0.590	1.000	0.996	0.154	982	.	.	.	.	MN1	75	0	256	21	0.075812274368231	TRUE	TRUE
ENSG00000165288.11	.	BCM	GRCh38.p13	chrX	80688125	80688125	+	C	C	A	Missense_Mutation	SNP	ENST00000373275.5	exon34	c.G3808T	p.D1270Y	exonic	ENSG00000165288.11	.	nonsynonymous SNV	ENSG00000165288.11:ENST00000373275.5:exon34:c.G3808T:p.D1270Y	Xq21.1	C3L-00589	.	.	.	.	.	.	.	.	.	8.19	D	D	D	P	N	D	M	T	N	0.315	T	T	D	0.084	0.323	0.454	1.120	T	T	T	T	D	T	5.002	33	0.990	D	.	.	.	.	.	0.417	.	.	.	.	.	5.000	5.000	5.188	1.026	0.599	1.000	0.989	0.889	681	.	.	.	.	BRWD3	114	0	93	13	0.122641509433962	TRUE	TRUE
ENSG00000155966.14	.	BCM	GRCh38.p13	chrX	148662537	148662537	+	C	C	G	Missense_Mutation	SNP	ENST00000370460.7	exon3	c.C810G	p.F270L	exonic	ENSG00000155966.14	.	nonsynonymous SNV	ENSG00000155966.14:ENST00000370460.7:exon3:c.C810G:p.F270L	Xq28	C3L-00589	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	D	D	M	T	D	0.741	T	D	D	0.594	0.684	0.681	0.644	T	D	D	D	D	D	3.114	23.700	0.998	D	.	.	.	.	.	0.222	.	.	.	.	.	5.710	2.890	0.831	-0.016	0.599	1.000	0.998	0.999	663	.	.	.	.	AFF2	198	0	251	41	0.14041095890411	TRUE	TRUE
ENSG00000160211.19	.	BCM	GRCh38.p13	chrX	154532605	154532606	+	CC	CC	-	Frame_Shift_Del	DEL	ENST00000393562.10	exon10	c.1248_1249del	p.E417Vfs*18	exonic	ENSG00000160211.19	.	frameshift deletion	ENSG00000160211.19:ENST00000393562.10:exon10:c.1248_1249del:p.E417Vfs*18	Xq28	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	G6PD	388	0	581	126	0.178217821782178	TRUE	TRUE
ENSG00000123106.10	.	BCM	GRCh38.p13	chr12	28362516	28362516	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000123106.10	ENST00000545336.5:exon10:c.654+1G>A	.	.	12p11.22	C3L-00589	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.655	34	0.994	D	.	1.094	17.247	0.939	15.552	0.889	0.294	0.333	0.063	0.057	0.969	5.510	5.510	5.927	1.131	0.595	1.000	0.995	0.997	843	.	.	.	.	CCDC91	123	0	104	9	0.079646017699115	TRUE	NA
ENSG00000077522.13	.	BCM	GRCh38.p13	chr1	236744762	236744762	+	C	C	T	Silent	SNP	ENST00000366578.6	exon12	c.C1392T	p.I464I	exonic	ENSG00000077522.13	.	synonymous SNV	ENSG00000077522.13:ENST00000366578.6:exon12:c.C1392T:p.I464I	1q43	C3L-00589	8.281e-06	0	0	0	0	1.507e-05	0	0	rs764086805	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63971447;OCCURENCE=1(breast),1(stomach),1(urinary_tract)	ACTN2	257	0	706	47	0.0624169986719788	TRUE	TRUE
ENSG00000071054.16	.	BCM	GRCh38.p13	chr2	101844209	101844209	+	G	G	A	Silent	SNP	ENST00000347699.8	exon12	c.G1131A	p.Q377Q	exonic	ENSG00000071054.16	.	synonymous SNV	ENSG00000071054.16:ENST00000347699.8:exon12:c.G1131A:p.Q377Q	2q11.2	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP4K4	254	0	322	64	0.16580310880829	TRUE	TRUE
ENSG00000136699.19	.	BCM	GRCh38.p13	chr2	130173594	130173594	+	G	G	A	Silent	SNP	ENST00000409031.5	exon4	c.C306T	p.L102L	exonic	ENSG00000136699.19	.	synonymous SNV	ENSG00000136699.19:ENST00000409031.5:exon4:c.C306T:p.L102L	2q21.1	C3L-00589	0.0055	0.0009	0.0037	0.0001	0.0014	0.0075	0.0077	0.0057	rs41269839	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60081228;OCCURENCE=1(lung)	SMPD4	162	0	452	40	0.0813008130081301	NA	TRUE
ENSG00000124006.15	.	BCM	GRCh38.p13	chr2	219557494	219557494	+	G	G	A	Silent	SNP	ENST00000404537.6	exon12	c.C3915T	p.D1305D	exonic	ENSG00000124006.15	.	synonymous SNV	ENSG00000124006.15:ENST00000404537.6:exon12:c.C3915T:p.D1305D	2q35	C3L-00589	.	.	.	.	.	.	.	.	rs926056344	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OBSL1	129	0	307	34	0.0997067448680352	TRUE	NA
ENSG00000171551.12	.	BCM	GRCh38.p13	chr2	232484196	232484196	+	G	G	A	Silent	SNP	ENST00000304546.6	exon7	c.C1212T	p.R404R	exonic	ENSG00000171551.12	.	synonymous SNV	ENSG00000171551.12:ENST00000304546.6:exon7:c.C1212T:p.R404R	2q37.1	C3L-00589	2.522e-05	0	0	0.0002	0	1.532e-05	0	0	rs764036925	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58812069;OCCURENCE=1(endometrium)	ECEL1	130	0	405	59	0.127155172413793	TRUE	TRUE
ENSG00000038295.8	.	BCM	GRCh38.p13	chr4	166091295	166091295	+	T	T	G	Silent	SNP	ENST00000061240.7	exon19	c.T2610G	p.S870S	exonic	ENSG00000038295.8	.	synonymous SNV	ENSG00000038295.8:ENST00000061240.7:exon19:c.T2610G:p.S870S	4q32.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TLL1	128	0	125	8	0.0601503759398496	TRUE	TRUE
ENSG00000164287.12	.	BCM	GRCh38.p13	chr5	55124923	55124923	+	C	C	T	Silent	SNP	ENST00000381375.6	exon9	c.G1095A	p.P365P	exonic	ENSG00000164287.12	.	synonymous SNV	ENSG00000164287.12:ENST00000381375.6:exon9:c.G1095A:p.P365P	5q11.2	C3L-00589	7.414e-05	0	0	0.0003	0	5.994e-05	0	0.0001	rs375917242	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57050982;OCCURENCE=1(large_intestine)	CDC20B	369	0	605	68	0.101040118870728	TRUE	TRUE
ENSG00000237441.10	.	BCM	GRCh38.p13	chr6	33298533	33298533	+	C	C	G	Silent	SNP	ENST00000497454.6	exon2	c.G78C	p.R26R	exonic	ENSG00000237441.10	.	synonymous SNV	ENSG00000237441.10:ENST00000497454.6:exon2:c.G78C:p.R26R	6p21.32	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RGL2	62	0	99	9	0.0833333333333333	TRUE	TRUE
ENSG00000064218.5	.	BCM	GRCh38.p13	chr9	977265	977265	+	C	C	T	Silent	SNP	ENST00000190165.3	exon1	c.C264T	p.P88P	exonic	ENSG00000064218.5	.	synonymous SNV	ENSG00000064218.5:ENST00000190165.3:exon1:c.C264T:p.P88P	9p24.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DMRT3	106	0	228	41	0.152416356877323	TRUE	TRUE
ENSG00000070159.14	.	BCM	GRCh38.p13	chr9	109404553	109404553	+	G	G	A	Silent	SNP	ENST00000374541.4	exon19	c.C1848T	p.P616P	exonic	ENSG00000070159.14	.	synonymous SNV	ENSG00000070159.14:ENST00000374541.4:exon19:c.C1848T:p.P616P	9q31.3	C3L-00589	2.495e-05	0	8.639e-05	0	0	3.011e-05	0	0	rs756050290	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTPN3	50	0	70	20	0.222222222222222	TRUE	NA
ENSG00000160323.18	.	BCM	GRCh38.p13	chr9	133440468	133440468	+	G	G	T	Silent	SNP	ENST00000371929.7	exon16	c.G1911T	p.L637L	exonic	ENSG00000160323.18	.	synonymous SNV	ENSG00000160323.18:ENST00000371929.7:exon16:c.G1911T:p.L637L	9q34.2	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAMTS13	193	1	452	46	0.0923694779116466	TRUE	TRUE
ENSG00000130560.9	.	BCM	GRCh38.p13	chr9	135946333	135946333	+	G	G	A	Silent	SNP	ENST00000371756.4	exon5	c.C480T	p.I160I	exonic	ENSG00000130560.9	.	synonymous SNV	ENSG00000130560.9:ENST00000371756.4:exon5:c.C480T:p.I160I	9q34.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBAC1	205	0	330	22	0.0625	TRUE	NA
ENSG00000172489.6	.	BCM	GRCh38.p13	chr11	56253165	56253165	+	G	G	A	Silent	SNP	ENST00000303059.3	exon1	c.G966A	p.L322L	exonic	ENSG00000172489.6	.	synonymous SNV	ENSG00000172489.6:ENST00000303059.3:exon1:c.G966A:p.L322L	11q12.1	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR5T3	49	0	56	6	0.0967741935483871	TRUE	TRUE
ENSG00000168060.16	.	BCM	GRCh38.p13	chr11	65053264	65053264	+	G	G	A	Silent	SNP	ENST00000358658.8	exon8	c.C1152T	p.A384A	exonic	ENSG00000168060.16	.	synonymous SNV	ENSG00000168060.16:ENST00000358658.8:exon8:c.C1152T:p.A384A	11q13.1	C3L-00589	0.0003	0	0	0	0	0.0003	0	0.0005	rs368997186	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NAALADL1	157	0	346	36	0.0942408376963351	TRUE	NA
ENSG00000149294.16	.	BCM	GRCh38.p13	chr11	113235142	113235142	+	C	C	T	Silent	SNP	ENST00000316851.11	exon14	c.C1803T	p.S601S	exonic	ENSG00000149294.16	.	synonymous SNV	ENSG00000149294.16:ENST00000316851.11:exon14:c.C1803T:p.S601S	11q23.2	C3L-00589	0.0003	0	0.0002	0	0	0.0001	0	0.0017	rs536431053	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57516384;OCCURENCE=1(large_intestine)	NCAM1	186	0	435	37	0.0783898305084746	TRUE	TRUE
ENSG00000175899.15	.	BCM	GRCh38.p13	chr12	9101645	9101645	+	G	G	A	Silent	SNP	ENST00000318602.12	exon12	c.C1296T	p.Y432Y	exonic	ENSG00000175899.15	.	synonymous SNV	ENSG00000175899.15:ENST00000318602.12:exon12:c.C1296T:p.Y432Y	12p13.31	C3L-00589	0.0510	0.0078	0.0222	0.0001	0.0374	0.0628	0.0629	0.0811	rs2228222	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	A2M	241	0	305	26	0.0785498489425982	TRUE	NA
ENSG00000060709.15	.	BCM	GRCh38.p13	chr12	130434821	130434821	+	G	G	A	Silent	SNP	ENST00000261655.8	exon11	c.C2115T	p.D705D	exonic	ENSG00000060709.15	.	synonymous SNV	ENSG00000060709.15:ENST00000261655.8:exon11:c.C2115T:p.D705D	12q24.33	C3L-00589	1.653e-05	9.662e-05	0	0	0	1.505e-05	0	0	rs761677291	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55467808;OCCURENCE=1(urinary_tract),1(lung),1(endometrium)	RIMBP2	233	0	398	79	0.165618448637317	TRUE	TRUE
ENSG00000041515.16	.	BCM	GRCh38.p13	chr13	109140430	109140430	+	G	G	A	Silent	SNP	ENST00000356711.7	exon32	c.G4152A	p.A1384A	exonic	ENSG00000041515.16	.	synonymous SNV	ENSG00000041515.16:ENST00000356711.7:exon32:c.G4152A:p.A1384A	13q33.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO16	199	0	535	52	0.0885860306643952	TRUE	TRUE
ENSG00000128881.17	.	BCM	GRCh38.p13	chr15	42777162	42777162	+	G	G	A	Silent	SNP	ENST00000267890.11	exon12	c.C1278T	p.V426V	exonic	ENSG00000128881.17	.	synonymous SNV	ENSG00000128881.17:ENST00000267890.11:exon12:c.C1278T:p.V426V	15q15.2	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TTBK2	420	0	521	50	0.0875656742556918	TRUE	NA
ENSG00000162069.16	.	BCM	GRCh38.p13	chr16	3031079	3031079	+	G	G	A	Silent	SNP	ENST00000572449.6	exon3	c.C354T	p.A118A	exonic	ENSG00000162069.16	.	synonymous SNV	ENSG00000162069.16:ENST00000572449.6:exon3:c.C354T:p.A118A	16p13.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BICDL2	235	0	728	57	0.0726114649681529	TRUE	NA
ENSG00000102935.11	.	BCM	GRCh38.p13	chr16	49637163	49637163	+	C	C	T	Silent	SNP	ENST00000561648.5	exon5	c.G1989A	p.A663A	exonic	ENSG00000102935.11	.	synonymous SNV	ENSG00000102935.11:ENST00000561648.5:exon5:c.G1989A:p.A663A	16q12.1	C3L-00589	0.0021	0.0006	0.0013	0	0.0036	0.0030	0	0.0004	rs143468235	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF423	172	0	353	52	0.128395061728395	TRUE	NA
ENSG00000179588.9	.	BCM	GRCh38.p13	chr16	88532708	88532708	+	C	C	T	Silent	SNP	ENST00000319555.8	exon8	c.C1041T	p.S347S	exonic	ENSG00000179588.9	.	synonymous SNV	ENSG00000179588.9:ENST00000319555.8:exon8:c.C1041T:p.S347S	16q24.2	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFPM1	188	0	487	47	0.0880149812734082	TRUE	TRUE
ENSG00000125414.19	.	BCM	GRCh38.p13	chr17	10535348	10535348	+	C	C	T	Silent	SNP	ENST00000245503.10	exon18	c.G1992A	p.L664L	exonic	ENSG00000125414.19	.	synonymous SNV	ENSG00000125414.19:ENST00000245503.10:exon18:c.G1992A:p.L664L	17p13.1	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYH2	370	0	365	29	0.0736040609137056	TRUE	TRUE
ENSG00000132005.9	.	BCM	GRCh38.p13	chr19	13978042	13978042	+	G	G	A	Silent	SNP	ENST00000254325.9	exon8	c.C879T	p.S293S	exonic	ENSG00000132005.9	.	synonymous SNV	ENSG00000132005.9:ENST00000254325.9:exon8:c.C879T:p.S293S	19p13.12	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RFX1	140	0	342	28	0.0756756756756757	TRUE	NA
ENSG00000177558.3	.	BCM	GRCh38.p13	chr19	35228312	35228312	+	C	C	T	Silent	SNP	ENST00000324675.3	exon1	c.G369A	p.L123L	exonic	ENSG00000177558.3	.	synonymous SNV	ENSG00000177558.3:ENST00000324675.3:exon1:c.G369A:p.L123L	19q13.12	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM187B	324	0	623	73	0.104885057471264	TRUE	NA
ENSG00000134830.6	.	BCM	GRCh38.p13	chr19	47340808	47340808	+	C	C	T	Silent	SNP	ENST00000595464.3	exon2	c.C9T	p.N3N	exonic	ENSG00000134830.6	.	synonymous SNV	ENSG00000134830.6:ENST00000595464.3:exon2:c.C9T:p.N3N	19q13.32	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57256903;OCCURENCE=1(oesophagus)	C5AR2	260	1	597	40	0.0627943485086342	TRUE	TRUE
ENSG00000198026.8	.	BCM	GRCh38.p13	chr20	45969590	45969590	+	G	G	A	Silent	SNP	ENST00000322927.3	exon3	c.C303T	p.G101G	exonic	ENSG00000198026.8	.	synonymous SNV	ENSG00000198026.8:ENST00000322927.3:exon3:c.C303T:p.G101G	20q13.12	C3L-00589	.	.	.	.	.	.	.	.	rs868406297	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59817884;OCCURENCE=2(lung)	ZNF335	74	0	172	11	0.0601092896174863	TRUE	TRUE
ENSG00000164556.7	.	BCM	GRCh38.p13	chr7	38686426	38686426	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000164556.7	.	.	.	7p14.1	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM183BP	132	0	271	20	0.0687285223367698	TRUE	NA
ENSG00000158528.12	.	BCM	GRCh38.p13	chr7	95269259	95269259	+	A	A	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000158528.12	.	.	.	7q21.3	C3L-00589	.	.	.	.	.	.	.	.	.	4.7	.	.	.	.	.	D	.	.	.	.	.	.	T	.	.	.	.	.	.	D	D	T	.	3.012	23.400	0.984	D	N	-0.187	1.912	-0.028	2.264	1.000	0.615	0.574	0.659	0.564	.	4.420	4.420	2.322	1.312	0.691	1.000	1.000	0.951	865	.	.	.	.	PPP1R9A	270	0	317	19	0.056547619047619	TRUE	TRUE
ENSG00000222468.1	.	BCM	GRCh38.p13	chr8	31639417	31639417	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000222468.1;ENSG00000286648.1	dist=41213;dist=187821	.	.	8p12	C3L-00589	.	.	.	.	.	.	.	.	rs777329120	4.14	D	T	.	.	.	N	.	T	N	0.226	T	T	D	0.171	0.434	0.389	.	.	.	T	T	D	T	2.881	23.200	0.996	D	N	0.040	2.656	0.092	2.703	1.000	0.437	0.563	0.607	0.555	.	3.450	3.450	2.871	1.089	0.618	1.000	0.954	0.779	875	.	.	.	.	RNA5SP261	273	0	703	70	0.0905562742561449	TRUE	NA
ENSG00000215114.10	.	BCM	GRCh38.p13	chr8	58434860	58434860	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000215114.10	.	.	.	8q12.1	C3L-00589	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	2.274	21.400	0.981	D	N	.	.	.	.	1.000	0.651	0.709	0.659	0.568	.	5.390	5.390	2.324	1.138	0.609	0.977	0.994	0.998	962	SEP_domain	.	.	.	UBXN2B	167	0	188	20	0.0961538461538462	TRUE	TRUE
ENSG00000279813.1	.	BCM	GRCh38.p13	chr9	136250896	136250896	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000279813.1	.	.	.	9q34.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CR392000.1	99	0	241	19	0.0730769230769231	TRUE	NA
ENSG00000256211.1	.	BCM	GRCh38.p13	chr12	16989067	16989067	+	G	G	A	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000256211.1	dist=59	.	.	12p12.3	C3L-00589	0	0	0	0	0	0	0	0	rs771370283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC023512.1	128	0	138	43	0.237569060773481	TRUE	NA
ENSG00000239438.1	.	BCM	GRCh38.p13	chr14	78243355	78243355	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000239438.1;ENSG00000258723.1	dist=11736;dist=36217	.	.	14q24.3	C3L-00589	0	0	0	0	0	0	0	0	rs779834039	4.7	.	D	.	.	.	.	.	.	.	0.655	T	T	.	0.341	.	.	.	.	T	.	.	.	D	3.474	24.600	0.999	D	D	0.487	4.939	0.597	6.185	1.000	0.638	0.590	0.653	0.564	.	6.160	6.160	6.108	1.026	0.599	1.000	0.996	0.983	555	Laminin_G_domain	.	.	.	RPS26P48	84	0	283	21	0.0690789473684211	TRUE	NA
ENSG00000105426.17	.	BCM	GRCh38.p13	chr19	5286165	5286165	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000105426.17	ENST00000587303.5:c.-25C>T	.	.	19p13.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTPRS	190	0	410	33	0.0744920993227991	TRUE	NA
ENSG00000125650.4	.	BCM	GRCh38.p13	chr19	6375850	6375850	+	T	T	A	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000125650.4;ENSG00000125652.8	dist=1;dist=600	.	.	19p13.3	C3L-00589	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PSPN	319	0	867	66	0.0707395498392283	TRUE	NA
ENSG00000143498.18	.	BCM	GRCh38.p13	chr1	222570634	222570645	+	GGCTACTGCATT	GGCTACTGCATT	-	In_Frame_Del	DEL	ENST00000352967.9	exon6	c.625_636del	p.N209_A212del	exonic	ENSG00000143498.18	.	nonframeshift deletion	ENSG00000143498.18:ENST00000352967.9:exon6:c.625_636del:p.N209_A212del	1q41	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TAF1A	103	0	218	36	0.141732283464567	TRUE	TRUE
ENSG00000143867.7	.	BCM	GRCh38.p13	chr2	19353211	19353211	+	C	C	T	Missense_Mutation	SNP	ENST00000272223.3	exon2	c.G595A	p.D199N	exonic	ENSG00000143867.7	.	nonsynonymous SNV	ENSG00000143867.7:ENST00000272223.3:exon2:c.G595A:p.D199N	2p24.1	C3N-00302	.	.	.	.	.	.	.	.	.	11.20	T	D	D	P	D	D	N	T	D	0.593	T	T	T	0.294	0.441	0.614	.	D	D	T	T	D	D	3.474	24.600	0.999	D	D	0.460	4.741	0.498	5.142	1.000	0.598	0.563	0.607	0.639	.	5.940	5.940	7.905	1.026	0.599	1.000	0.706	0.799	917	Zinc_finger_C2H2-type	.	.	.	OSR1	317	1	518	145	0.218702865761689	TRUE	NA
ENSG00000084674.15	.	BCM	GRCh38.p13	chr2	21012072	21012072	+	C	C	T	Missense_Mutation	SNP	ENST00000233242.5	exon26	c.G4796A	p.R1599H	exonic	ENSG00000084674.15	.	nonsynonymous SNV	ENSG00000084674.15:ENST00000233242.5:exon26:c.G4796A:p.R1599H	2p24.1	C3N-00302	0.0001	0	0	0.0010	0	1.502e-05	0	0.0003	rs746414462	7.15	D	D	.	.	D	D	.	T	D	0.192	T	T	T	0.200	0.297	0.743	0.045	T	.	T	T	T	.	2.397	22.100	0.999	D	D	0.586	5.782	0.564	5.795	1.000	0.554	0.590	0.618	0.621	.	5.980	5.980	2.005	1.026	0.599	0.999	0.879	0.672	863	.	.	.	ID=COSV51927055;OCCURENCE=1(large_intestine),1(stomach),1(upper_aerodigestive_tract),1(endometrium)	APOB	69	0	168	45	0.211267605633803	TRUE	TRUE
ENSG00000136709.12	.	BCM	GRCh38.p13	chr2	127720275	127720275	+	C	C	T	Missense_Mutation	SNP	ENST00000322313.9	exon16	c.G1750A	p.G584R	exonic	ENSG00000136709.12	.	nonsynonymous SNV	ENSG00000136709.12:ENST00000322313.9:exon16:c.G1750A:p.G584R	2q14.3	C3N-00302	4.513e-05	0	0	0.0006	0	0	0	0	rs774069217	7.20	D	T	B	B	N	D	L	D	N	0.768	T	D	D	0.346	0.480	0.396	0.418	T	T	T	T	T	D	2.467	22.300	0.992	D	N	-0.124	2.101	0.007	2.383	0.981	0.707	0.725	0.725	0.714	.	5.290	4.410	2.631	1.026	0.549	0.983	0.973	0.997	934	.	.	.	.	WDR33	43	0	62	4	0.0606060606060606	TRUE	NA
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140485508	140485508	+	G	G	A	Missense_Mutation	SNP	ENST00000389484.8	exon59	c.C9260T	p.A3087V	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon59:c.C9260T:p.A3087V	2q22.1	C3N-00302	1.687e-05	0	0	0	0	3.075e-05	0	0	rs753066569	14.20	D	T	D	P	D	D	N	D	N	0.748	D	D	D	0.608	.	0.429	0.602	T	T	D	D	D	D	4.228	28.900	0.999	D	D	0.606	5.989	0.678	7.358	0.039	0.487	0.574	0.574	0.564	.	5.430	5.430	9.499	1.172	0.676	1.000	0.988	0.963	955	Domain_of_unknown_function_DUF5050	.	.	ID=COSV67232817;OCCURENCE=4(lung)	LRP1B	65	0	136	31	0.18562874251497	TRUE	TRUE
ENSG00000169047.5	.	BCM	GRCh38.p13	chr2	226795968	226795968	+	G	G	A	Missense_Mutation	SNP	ENST00000305123.5	exon1	c.C2771T	p.P924L	exonic	ENSG00000169047.5	.	nonsynonymous SNV	ENSG00000169047.5:ENST00000305123.5:exon1:c.C2771T:p.P924L	2q36.3	C3N-00302	8.258e-06	0	0	0.0001	0	0	0	0	rs747061950	2.20	D	T	B	B	N	D	N	T	N	0.057	T	T	T	0.057	0.353	0.686	0.272	T	T	T	T	T	T	2.120	20.300	0.879	N	N	-0.679	0.848	-0.619	1.018	1.000	0.722	0.588	0.699	0.605	.	4.930	3.110	1.163	1.176	0.676	0.001	0.995	0.996	942	.	.	.	.	IRS1	528	1	735	203	0.216417910447761	TRUE	NA
ENSG00000081052.13	.	BCM	GRCh38.p13	chr2	227060156	227060156	+	G	G	A	Missense_Mutation	SNP	ENST00000396625.5	exon27	c.C2144T	p.A715V	exonic	ENSG00000081052.13	.	nonsynonymous SNV	ENSG00000081052.13:ENST00000396625.5:exon27:c.C2144T:p.A715V	2q36.3	C3N-00302	0.0002	0	0.0002	0.0001	0	0.0002	0	0.0003	rs76636743	3.19	T	T	B	B	.	N	L	D	N	0.400	T	D	D	0.202	.	0.682	0.154	T	T	T	T	T	T	1.522	15.880	0.986	N	N	-0.411	1.360	-0.388	1.394	1.000	0.554	0.588	0.618	0.564	.	5.750	5.750	3.413	1.176	0.676	0.219	0.002	0.005	806	.	.	.	ID=COSV99052140;OCCURENCE=2(large_intestine),1(kidney)	COL4A4	227	1	352	97	0.216035634743875	TRUE	NA
ENSG00000181789.14	.	BCM	GRCh38.p13	chr3	129255003	129255003	+	A	A	G	Missense_Mutation	SNP	ENST00000314797.10	exon7	c.A418G	p.I140V	exonic	ENSG00000181789.14	.	nonsynonymous SNV	ENSG00000181789.14:ENST00000314797.10:exon7:c.A418G:p.I140V	3q21.3	C3N-00302	5.768e-05	0.0003	0	0	0	1.499e-05	0	0.0002	rs367768969	5.20	T	T	B	P	N	D	M	T	N	0.230	T	T	T	0.176	.	0.438	0.847	T	T	T	T	T	D	2.797	23.000	0.989	D	D	0.145	3.069	0.155	2.970	0.988	0.707	0.698	0.725	0.714	.	4.150	3.000	7.077	0.269	0.691	1.000	0.992	0.979	523	Clathrin/coatomer_adaptor,_adaptin-like,_N-terminal	.	.	.	COPG1	128	0	339	68	0.167076167076167	TRUE	NA
ENSG00000174564.13	.	BCM	GRCh38.p13	chr3	136989476	136989476	+	G	G	C	Missense_Mutation	SNP	ENST00000329582.9	exon4	c.G442C	p.D148H	exonic	ENSG00000174564.13	.	nonsynonymous SNV	ENSG00000174564.13:ENST00000329582.9:exon4:c.G442C:p.D148H	3q22.3	C3N-00302	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	L	T	D	0.168	T	T	T	0.040	0.654	0.358	0.318	T	T	T	T	D	T	2.364	21.900	0.975	D	N	-0.212	1.844	-0.065	2.150	0.985	0.615	0.588	0.659	0.613	.	4.900	4.010	2.343	0.169	0.676	0.968	0.992	0.974	733	.	.	.	.	IL20RB	229	0	578	41	0.0662358642972536	TRUE	TRUE
ENSG00000205359.10	.	BCM	GRCh38.p13	chr5	102477840	102477840	+	A	A	G	Missense_Mutation	SNP	ENST00000506729.6	exon3	c.T638C	p.V213A	exonic	ENSG00000205359.10	.	nonsynonymous SNV	ENSG00000205359.10:ENST00000506729.6:exon3:c.T638C:p.V213A	5q21.1	C3N-00302	.	.	.	.	.	.	.	.	rs572687157	0.19	T	T	B	B	.	N	L	T	N	0.120	T	T	T	0.017	0.387	0.048	0.143	T	T	T	T	T	T	-0.143	0.676	0.425	N	N	-1.272	0.180	-1.312	0.202	0.000	0.487	0.574	0.574	0.564	.	4.780	-1.250	-0.212	-0.680	-0.810	0.000	0.000	0.000	237	Major_facilitator_superfamily_domain	.	.	.	SLCO6A1	55	0	133	37	0.217647058823529	TRUE	NA
ENSG00000113209.9	.	BCM	GRCh38.p13	chr5	141137700	141137700	+	G	G	A	Missense_Mutation	SNP	ENST00000231134.8	exon1	c.G2266A	p.G756R	exonic	ENSG00000113209.9	.	nonsynonymous SNV	ENSG00000113209.9:ENST00000231134.8:exon1:c.G2266A:p.G756R	5q31.3	C3N-00302	2.479e-05	0	0	0	0.0002	1.498e-05	0	6.056e-05	rs781995647	4.14	D	D	.	.	.	N	.	T	D	0.165	T	T	D	0.080	.	0.645	0.528	T	.	T	T	T	.	2.155	20.500	0.923	N	N	-0.411	1.358	-0.608	1.034	0.000	0.650	0.547	0.607	0.621	.	4.380	0.922	0.478	1.082	0.561	0.000	0.029	0.085	554	.	.	.	ID=COSV50647659;OCCURENCE=2(large_intestine),1(skin)	PCDHB5	247	0	439	134	0.233856893542757	TRUE	TRUE
ENSG00000262209.3	.	BCM	GRCh38.p13	chr5	141372259	141372259	+	G	G	A	Missense_Mutation	SNP	ENST00000576222.2	exon1	c.G1865A	p.R622H	exonic	ENSG00000262209.3	.	nonsynonymous SNV	ENSG00000262209.3:ENST00000576222.2:exon1:c.G1865A:p.R622H	5q31.3	C3N-00302	.	.	.	.	.	.	.	.	.	1.13	.	T	D	P	.	N	N	T	.	0.210	.	.	T	.	.	0.820	0.305	.	T	T	T	.	T	1.285	14.280	0.901	N	N	.	.	.	.	0.976	0.549	0.588	0.578	0.616	.	5.140	4.240	0.037	-0.210	-0.123	0.000	0.055	0.002	650	Cadherin-like	.	.	.	PCDHGB3	211	0	469	62	0.116760828625235	TRUE	NA
ENSG00000136193.17	.	BCM	GRCh38.p13	chr7	29936568	29936574	+	GGGGTTC	GGGGTTC	-	Frame_Shift_Del	DEL	ENST00000242059.10	exon6	c.887_893del	p.G296Vfs*17	exonic	ENSG00000136193.17	.	frameshift deletion	ENSG00000136193.17:ENST00000242059.10:exon6:c.887_893del:p.G296Vfs*17	7p14.3	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCRN1	88	0	71	19	0.211111111111111	TRUE	TRUE
ENSG00000164532.11	.	BCM	GRCh38.p13	chr7	35253583	35253583	+	G	G	A	Missense_Mutation	SNP	ENST00000408931.4	exon1	c.C38T	p.S13F	exonic	ENSG00000164532.11	.	nonsynonymous SNV	ENSG00000164532.11:ENST00000408931.4:exon1:c.C38T:p.S13F	7p14.2	C3N-00302	.	.	.	.	.	.	.	.	.	16.20	D	D	D	P	D	D	L	D	N	0.465	D	D	D	0.543	0.286	0.971	1.509	D	T	D	D	D	D	4.524	32	0.995	D	D	0.582	5.746	0.628	6.586	1.000	0.598	0.563	0.378	0.639	.	5.070	5.070	9.565	1.176	0.676	1.000	0.999	0.993	798	.	.	.	.	TBX20	192	0	389	21	0.0512195121951219	TRUE	NA
ENSG00000279961.2	.	BCM	GRCh38.p13	chr11	56417860	56417860	+	C	C	T	Missense_Mutation	SNP	ENST00000623286.1	exon1	c.G373A	p.A125T	exonic	ENSG00000279961.2	.	nonsynonymous SNV	ENSG00000279961.2:ENST00000623286.1:exon1:c.G373A:p.A125T	11q12.1	C3N-00302	8.242e-06	0	0	0	0	1.499e-05	0	0	rs771782696	8.16	.	.	D	D	U	D	M	.	.	.	T	T	D	0.215	0.632	.	.	T	T	T	T	D	D	3.509	24.700	0.999	D	N	0.859	10.054	0.775	9.422	0.982	0.487	0.574	0.574	0.564	.	5.780	5.780	4.980	0.104	-0.193	1.000	0.643	0.003	185	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV56571910;OCCURENCE=2(breast),2(prostate)	OR5R1	161	0	291	37	0.11280487804878	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-00302	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	236	0	424	123	0.224862888482633	TRUE	TRUE
ENSG00000139687.15	.	BCM	GRCh38.p13	chr13	48453046	48453046	+	T	T	-	Frame_Shift_Del	DEL	ENST00000267163.5	exon18	c.1749delT	p.D584Ifs*27	exonic	ENSG00000139687.15	.	frameshift deletion	ENSG00000139687.15:ENST00000267163.5:exon18:c.1749delT:p.D584Ifs*27	13q14.2	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RB1	141	0	292	170	0.367965367965368	TRUE	TRUE
ENSG00000156030.13	.	BCM	GRCh38.p13	chr14	73719432	73719432	+	C	C	T	Missense_Mutation	SNP	ENST00000286523.9	exon12	c.G3007A	p.E1003K	exonic	ENSG00000156030.13	.	nonsynonymous SNV	ENSG00000156030.13:ENST00000286523.9:exon12:c.G3007A:p.E1003K	14q24.3	C3N-00302	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	N	N	T	N	0.268	T	T	T	0.170	0.255	0.321	0.791	T	T	T	T	D	D	2.154	20.500	0.998	D	N	-0.077	2.248	0.025	2.448	1.000	0.707	0.702	0.619	0.714	.	5.780	5.780	1.503	1.026	0.599	0.896	0.621	0.499	447	.	.	.	.	MIDEAS	476	1	727	199	0.214902807775378	TRUE	TRUE
ENSG00000119681.12	.	BCM	GRCh38.p13	chr14	74552898	74552898	+	G	G	A	Missense_Mutation	SNP	ENST00000261978.9	exon5	c.C1186T	p.R396C	exonic	ENSG00000119681.12	.	nonsynonymous SNV	ENSG00000119681.12:ENST00000261978.9:exon5:c.C1186T:p.R396C	14q24.3	C3N-00302	2.09e-05	0	0	0	0	3.727e-05	0	0	rs753186679	15.20	D	D	D	D	D	D	M	T	D	0.811	T	T	T	0.291	0.554	0.660	0.720	T	D	D	D	D	D	4.569	32	0.999	D	D	0.657	6.559	0.639	6.749	1.000	0.714	0.590	0.576	0.617	.	4.830	4.830	5.782	1.176	0.674	1.000	1.000	0.997	257	EGF-like_domain	.	.	.	LTBP2	328	0	537	106	0.164852255054432	TRUE	NA
ENSG00000277322.1	.	BCM	GRCh38.p13	chr15	20538638	20538638	+	C	C	T	Missense_Mutation	SNP	ENST00000619213.1	exon3	c.G340A	p.E114K	exonic	ENSG00000277322.1	.	nonsynonymous SNV	ENSG00000277322.1:ENST00000619213.1:exon3:c.G340A:p.E114K	15q11.2	C3N-00302	.	.	.	.	.	.	.	.	.	2.13	.	D	.	.	.	N	.	.	.	0.123	T	T	T	0.054	.	0.113	.	T	T	T	T	D	T	1.944	18.830	0.950	N	N	-0.290	1.639	-0.571	1.090	0.000	0.487	0.574	0.574	0.564	.	0.109	0.109	-0.027	0.369	0.302	0.218	0.024	0.026	1000	.	.	.	.	GOLGA6L6	30	0	41	12	0.226415094339623	NA	TRUE
ENSG00000205456.11	.	BCM	GRCh38.p13	chr16	32253570	32253570	+	C	C	A	Missense_Mutation	SNP	ENST00000398664.4	exon1	c.C217A	p.L73I	exonic	ENSG00000205456.11	.	nonsynonymous SNV	ENSG00000205456.11:ENST00000398664.4:exon1:c.C217A:p.L73I	16p11.2	C3N-00302	.	.	.	.	.	.	.	.	.	2.11	D	D	.	.	.	N	.	T	N	0.099	.	.	T	.	.	0.123	2.370	T	.	T	T	.	.	0.918	10.630	0.881	N	N	.	.	.	.	0.001	0.487	0.574	0.574	0.564	.	0.253	-0.507	0.173	0.215	0.191	0.017	0.017	0.020	721	.	.	.	.	TP53TG3D	208	0	190	83	0.304029304029304	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7670691	7670691	+	T	T	-	Frame_Shift_Del	DEL	ENST00000269305.8	exon10	c.1018delA	p.M340Cfs*5	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon10:c.1018delA:p.M340Cfs*5	17p13.1	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53461649;OCCURENCE=1(stomach)	TP53	306	0	304	116	0.276190476190476	TRUE	TRUE
ENSG00000215421.9	.	BCM	GRCh38.p13	chr18	74631710	74631710	+	C	C	-	Frame_Shift_Del	DEL	ENST00000299687.9	exon1	c.691delC	p.H231Ifs*29	exonic	ENSG00000215421.9	.	frameshift deletion	ENSG00000215421.9:ENST00000299687.9:exon1:c.691delC:p.H231Ifs*29	18q22.3	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF407	166	1	212	70	0.24822695035461	TRUE	TRUE
ENSG00000101445.10	.	BCM	GRCh38.p13	chr20	38918592	38918592	+	C	C	G	Missense_Mutation	SNP	ENST00000299824.6	exon11	c.C1630G	p.P544A	exonic	ENSG00000101445.10	.	nonsynonymous SNV	ENSG00000101445.10:ENST00000299824.6:exon11:c.C1630G:p.P544A	20q11.23	C3N-00302	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.553	D	D	D	0.493	0.485	0.773	1.146	T	D	D	D	D	D	3.492	24.700	0.996	D	D	0.734	7.624	0.714	8.016	1.000	0.707	0.698	0.659	0.714	.	5.350	5.350	5.013	1.026	0.599	1.000	0.998	0.995	888	.	.	.	ID=COSV55379747;OCCURENCE=1(urinary_tract)	PPP1R16B	23	0	44	5	0.102040816326531	TRUE	TRUE
ENSG00000179750.16	.	BCM	GRCh38.p13	chr22	38989551	38989551	+	C	C	T	Missense_Mutation	SNP	ENST00000333467.4	exon5	c.C664T	p.R222C	exonic	ENSG00000179750.16	.	nonsynonymous SNV	ENSG00000179750.16:ENST00000333467.4:exon5:c.C664T:p.R222C	22q13.1	C3N-00302	1.7e-05	0	0	0	0	1.517e-05	0	6.267e-05	rs151250472	4.19	D	T	B	B	.	N	M	D	N	0.217	T	D	T	0.393	.	0.751	0.317	T	T	T	T	T	T	0.702	8.476	0.896	N	N	-0.947	0.464	-1.228	0.260	0.992	0.722	0.699	0.644	0.613	.	1.920	-3.740	-0.122	0.687	0.486	0.001	0.003	0.009	356	APOBEC-like,_N-terminal;Cytidine_and_deoxycytidylate_deaminase_domain	.	.	.	APOBEC3B	147	0	193	14	0.0676328502415459	TRUE	NA
ENSG00000214717.12	.	BCM	GRCh38.p13	chrX	2488649	2488649	+	T	T	C	Missense_Mutation	SNP	ENST00000652001.1	exon2	c.A2071G	p.S691G	exonic	ENSG00000214717.12	.	nonsynonymous SNV	ENSG00000214717.12:ENST00000652001.1:exon2:c.A2071G:p.S691G	Xp22.33	C3N-00302	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	N	N	N	.	N	0.113	T	T	T	0.051	0.104	0.105	0.390	T	T	T	T	T	T	0.193	3.049	0.513	N	.	.	.	.	.	1.000	.	.	.	.	.	2.460	-4.070	0.423	-0.551	-0.375	0.998	0.002	0.002	1000	.	.	.	.	ZBED1	91	0	88	41	0.317829457364341	TRUE	TRUE
ENSG00000172901.20	.	BCM	GRCh38.p13	chr5	116015767	116015767	+	T	T	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000172901.20	ENST00000357872.9:exon18:c.2756+2T>A	.	.	5q23.1	C3N-00302	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.415	34	0.990	D	.	0.925	11.708	0.745	8.688	0.062	0.075	0.110	0.060	0.057	0.956	5.600	5.600	4.245	1.138	0.665	1.000	0.998	0.660	941	.	.	.	.	LVRN	52	0	135	37	0.215116279069767	TRUE	TRUE
ENSG00000116882.14	.	BCM	GRCh38.p13	chr1	119393813	119393813	+	A	A	T	Silent	SNP	ENST00000622548.4	exon9	c.A1029T	p.R343R	exonic	ENSG00000116882.14	.	synonymous SNV	ENSG00000116882.14:ENST00000622548.4:exon9:c.A1029T:p.R343R	1p12	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HAO2	198	0	326	95	0.225653206650831	TRUE	TRUE
ENSG00000058085.15	.	BCM	GRCh38.p13	chr1	183227582	183227582	+	C	C	T	Silent	SNP	ENST00000264144.5	exon10	c.C1353T	p.N451N	exonic	ENSG00000058085.15	.	synonymous SNV	ENSG00000058085.15:ENST00000264144.5:exon10:c.C1353T:p.N451N	1q25.3	C3N-00302	0.0002	0.0004	0	0	0	0.0001	0	0.0006	rs141522697	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LAMC2	346	0	570	114	0.166666666666667	TRUE	NA
ENSG00000182568.17	.	BCM	GRCh38.p13	chr3	18394726	18394726	+	A	A	T	Silent	SNP	ENST00000338745.11	exon7	c.T942A	p.P314P	exonic	ENSG00000182568.17	.	synonymous SNV	ENSG00000182568.17:ENST00000338745.11:exon7:c.T942A:p.P314P	3p24.3	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SATB1	249	0	370	76	0.170403587443946	TRUE	TRUE
ENSG00000144744.17	.	BCM	GRCh38.p13	chr3	69077894	69077894	+	C	C	A	Silent	SNP	ENST00000361055.9	exon3	c.G87T	p.G29G	exonic	ENSG00000144744.17	.	synonymous SNV	ENSG00000144744.17:ENST00000361055.9:exon3:c.G87T:p.G29G	3p14.1	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBA3	178	0	264	76	0.223529411764706	TRUE	TRUE
ENSG00000198944.6	.	BCM	GRCh38.p13	chr5	132814533	132814533	+	G	G	A	Silent	SNP	ENST00000378693.4	exon1	c.G912A	p.A304A	exonic	ENSG00000198944.6	.	synonymous SNV	ENSG00000198944.6:ENST00000378693.4:exon1:c.G912A:p.A304A	5q31.1	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SOWAHA	35	0	247	15	0.0572519083969466	TRUE	TRUE
ENSG00000186340.15	.	BCM	GRCh38.p13	chr6	169220268	169220268	+	G	G	A	Silent	SNP	ENST00000366787.7	exon22	c.C3441T	p.G1147G	exonic	ENSG00000186340.15	.	synonymous SNV	ENSG00000186340.15:ENST00000366787.7:exon22:c.C3441T:p.G1147G	6q27	C3N-00302	0.0080	0.0883	0.0029	0	0	0.0002	0.0077	6.056e-05	rs59953407	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64677242;OCCURENCE=1(large_intestine)	THBS2	136	0	231	16	0.0647773279352227	TRUE	TRUE
ENSG00000111046.4	.	BCM	GRCh38.p13	chr12	80707983	80707983	+	A	A	G	Silent	SNP	ENST00000228641.4	exon1	c.A264G	p.K88K	exonic	ENSG00000111046.4	.	synonymous SNV	ENSG00000111046.4:ENST00000228641.4:exon1:c.A264G:p.K88K	12q21.31	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYF6	537	0	816	241	0.228003784295175	TRUE	TRUE
ENSG00000229474.6	.	BCM	GRCh38.p13	chr15	44669354	44669354	+	G	G	A	Silent	SNP	ENST00000434130.5	exon11	c.C990T	p.C330C	exonic	ENSG00000229474.6	.	synonymous SNV	ENSG00000229474.6:ENST00000434130.5:exon11:c.C990T:p.C330C	15q21.1	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PATL2	224	0	182	67	0.269076305220884	TRUE	TRUE
ENSG00000103647.13	.	BCM	GRCh38.p13	chr15	68695175	68695175	+	C	C	T	Silent	SNP	ENST00000261861.10	exon3	c.C252T	p.C84C	exonic	ENSG00000103647.13	.	synonymous SNV	ENSG00000103647.13:ENST00000261861.10:exon3:c.C252T:p.C84C	15q23	C3N-00302	1.65e-05	0	0	0	0	0	0	0.0001	rs775653466	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99962893;OCCURENCE=1(stomach)	CORO2B	285	0	270	124	0.314720812182741	TRUE	NA
ENSG00000182087.14	.	BCM	GRCh38.p13	chr19	1020817	1020817	+	G	G	A	Silent	SNP	ENST00000356663.8	exon1	c.C180T	p.F60F	exonic	ENSG00000182087.14	.	synonymous SNV	ENSG00000182087.14:ENST00000356663.8:exon1:c.C180T:p.F60F	19p13.3	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM259	29	0	37	9	0.195652173913043	TRUE	TRUE
ENSG00000105270.15	.	BCM	GRCh38.p13	chr19	36027138	36027138	+	G	G	A	Silent	SNP	ENST00000360535.9	exon3	c.C300T	p.G100G	exonic	ENSG00000105270.15	.	synonymous SNV	ENSG00000105270.15:ENST00000360535.9:exon3:c.C300T:p.G100G	19q13.12	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLIP3	46	0	160	9	0.0532544378698225	TRUE	TRUE
ENSG00000236065.2	.	BCM	GRCh38.p13	chr1	33012572	33012572	+	C	C	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000236065.2	.	.	.	1p35.1	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL020995.1	111	0	414	38	0.084070796460177	TRUE	NA
ENSG00000136238.18	.	BCM	GRCh38.p13	chr7	6398712	6398712	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000136238.18	.	.	.	7p22.1	C3N-00302	9.43e-05	0.0009	0	0	0	1.571e-05	0	6.308e-05	rs148122613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61821656;OCCURENCE=1(endometrium)	RAC1	148	1	266	54	0.16875	TRUE	TRUE
ENSG00000148204.12	.	BCM	GRCh38.p13	chr9	123373942	123373942	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000148204.12	.	.	.	9q33.3	C3N-00302	.	.	.	.	.	.	.	.	rs943584708	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CRB2	159	0	277	60	0.178041543026706	TRUE	NA
ENSG00000186452.11	.	BCM	GRCh38.p13	chr12	50885553	50885553	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000186452.11	.	.	.	12q13.12	C3N-00302	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMPRSS12	50	0	137	10	0.0680272108843537	TRUE	TRUE
ENSG00000116731.22	.	BCM	GRCh38.p13	chr1	13778596	13778610	+	GGAAGAGGAGGAGGA	GGAAGAGGAGGAGGA	-	In_Frame_Del	DEL	ENST00000235372.11	exon8	c.801_815del	p.E272_E276del	exonic	ENSG00000116731.22	.	nonframeshift deletion	ENSG00000116731.22:ENST00000235372.11:exon8:c.801_815del:p.E272_E276del	1p36.21	C3L-03743	8.263e-05	0	0	0.0003	0	7.522e-05	0	0.0001	rs770109313	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRDM2	278	0	389	71	0.154347826086957	TRUE	NA
ENSG00000142798.20	.	BCM	GRCh38.p13	chr1	21844276	21844276	+	G	G	T	Missense_Mutation	SNP	ENST00000374695.8	exon65	c.C8488A	p.R2830S	exonic	ENSG00000142798.20	.	nonsynonymous SNV	ENSG00000142798.20:ENST00000374695.8:exon65:c.C8488A:p.R2830S	1p36.12	C3L-03743	.	.	.	.	.	.	.	.	.	4.20	T	T	D	D	N	N	L	T	N	0.591	T	T	T	0.182	0.554	0.539	0.691	T	T	T	T	D	T	3.238	24.000	0.998	D	N	0.286	3.709	0.272	3.560	0.014	0.672	0.588	0.702	0.711	.	4.820	3.800	2.144	0.194	-0.154	1.000	0.563	0.009	846	Immunoglobulin_I-set;Immunoglobulin_V-set_domain;Immunoglobulin-like_domain	.	.	.	HSPG2	100	0	184	19	0.0935960591133005	TRUE	TRUE
ENSG00000168710.18	.	BCM	GRCh38.p13	chr1	110012927	110012927	+	G	G	A	Missense_Mutation	SNP	ENST00000369799.10	exon5	c.G508A	p.A170T	exonic	ENSG00000168710.18	.	nonsynonymous SNV	ENSG00000168710.18:ENST00000369799.10:exon5:c.G508A:p.A170T	1p13.3	C3L-03743	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.896	D	D	D	0.699	0.911	0.927	2.333	T	D	D	D	D	D	4.186	28.500	0.999	D	D	1.219	25.549	1.138	32.224	1.000	0.722	0.699	0.725	0.714	.	6.170	6.170	10.003	1.175	0.676	1.000	1.000	0.998	173	.	.	.	.	AHCYL1	121	0	231	41	0.150735294117647	TRUE	TRUE
ENSG00000160688.19	.	BCM	GRCh38.p13	chr1	154988849	154988849	+	G	G	C	Missense_Mutation	SNP	ENST00000292180.8	exon2	c.G1117C	p.G373R	exonic	ENSG00000160688.19	.	nonsynonymous SNV	ENSG00000160688.19:ENST00000292180.8:exon2:c.G1117C:p.G373R	1q21.3	C3L-03743	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	D	D	M	.	N	0.568	T	T	T	0.228	0.434	0.641	0.273	T	T	D	D	D	D	3.940	26.600	0.998	D	D	0.564	5.572	0.613	6.387	1.000	0.707	0.702	0.702	0.714	.	5.650	5.650	4.603	1.176	0.676	1.000	0.980	0.988	374	.	.	.	.	FLAD1	238	0	464	37	0.0738522954091816	TRUE	TRUE
ENSG00000136636.13	.	BCM	GRCh38.p13	chr1	215620450	215620450	+	-	NA	G	Frame_Shift_Ins	NA	ENST00000259154.9	exon18	c.2281dupG	p.G763Rfs*23	exonic	ENSG00000136636.13	.	frameshift insertion	ENSG00000136636.13:ENST00000259154.9:exon18:c.2281dupG:p.G763Rfs*23	1q41	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCTD3	NA	NA	NA	NA	NA	NA	NA
ENSG00000198104.3	.	BCM	GRCh38.p13	chr1	248388136	248388136	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000641644.1	exon3	c.529dupT	p.C179Lfs*2	exonic	ENSG00000198104.3	.	frameshift insertion	ENSG00000198104.3:ENST00000641644.1:exon3:c.529dupT:p.C179Lfs*2	1q44	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR2T6	NA	NA	NA	NA	NA	NA	NA
ENSG00000173567.15	.	BCM	GRCh38.p13	chr2	26311924	26311924	+	C	C	A	Missense_Mutation	SNP	ENST00000311519.5	exon11	c.G1804T	p.A602S	exonic	ENSG00000173567.15	.	nonsynonymous SNV	ENSG00000173567.15:ENST00000311519.5:exon11:c.G1804T:p.A602S	2p23.3	C3L-03743	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	.	N	.	T	N	0.030	T	T	T	0.018	0.499	0.030	0.076	T	T	T	T	T	T	-0.216	0.471	0.647	N	N	-1.660	0.043	-1.497	0.109	0.977	0.554	0.588	0.602	0.542	.	6.110	-2.510	-0.105	-0.843	-0.791	0.456	0.019	0.344	445	.	.	.	.	ADGRF3	315	1	537	100	0.156985871271586	TRUE	TRUE
ENSG00000182389.19	.	BCM	GRCh38.p13	chr2	151870580	151870580	+	G	G	A	Missense_Mutation	SNP	ENST00000637559.1	exon7	c.C548T	p.P183L	exonic	ENSG00000182389.19;ENSG00000283228.1	.	nonsynonymous SNV	ENSG00000283228.1:ENST00000637559.1:exon7:c.C548T:p.P183L,ENSG00000182389.19:ENST00000539935.6:exon8:c.C650T:p.P217L	2q23.3	C3L-03743	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.909	D	D	D	0.816	0.753	0.974	1.629	D	D	D	D	D	D	4.505	32	0.999	D	D	1.043	15.344	1.006	19.200	1.000	0.615	0.660	0.659	0.616	.	5.910	5.910	9.962	1.176	0.676	1.000	0.428	0.961	801	.	.	.	.	CACNB4	124	1	228	48	0.173913043478261	TRUE	TRUE
ENSG00000138356.14	.	BCM	GRCh38.p13	chr2	200612655	200612655	+	C	C	T	Missense_Mutation	SNP	ENST00000374700.7	exon14	c.C1310T	p.A437V	exonic	ENSG00000138356.14	.	nonsynonymous SNV	ENSG00000138356.14:ENST00000374700.7:exon14:c.C1310T:p.A437V	2q33.1	C3L-03743	1.649e-05	0	0	0	0	1.499e-05	0	6.06e-05	rs368293055	13.20	T	D	D	D	D	D	M	T	D	0.652	T	T	D	0.366	.	0.474	0.505	T	D	T	T	D	D	2.985	23.400	0.999	D	D	0.801	8.803	0.759	9.008	1.000	0.638	0.547	0.653	0.613	.	5.410	5.410	3.575	1.026	0.599	0.994	0.926	0.929	676	CO_dehydrogenase_flavoprotein,_C-terminal	.	.	ID=COSV65981353;OCCURENCE=1(oesophagus),1(large_intestine),1(lung),1(endometrium)	AOX1	109	0	219	19	0.0798319327731092	TRUE	TRUE
ENSG00000072195.15	.	BCM	GRCh38.p13	chr2	219492746	219492746	+	G	G	A	Missense_Mutation	SNP	ENST00000312358.12	exon41	c.G9764A	p.R3255H	exonic	ENSG00000072195.15;ENSG00000286143.1	.	nonsynonymous SNV	ENSG00000072195.15:ENST00000312358.12:exon41:c.G9764A:p.R3255H	2q35	C3L-03743	0.0010	0.0010	0.0011	0.0002	0	0.0014	0	0	rs55821615	6.20	D	D	B	B	N	N	N	T	D	0.102	T	T	D	0.088	.	0.252	0.489	T	T	T	T	T	D	3.106	23.600	0.999	D	N	-0.317	1.572	-0.140	1.937	1.000	0.497	0.590	0.299	0.542	.	4.770	2.950	4.475	1.176	0.618	1.000	0.998	0.995	107	.	.	.	ID=COSV100403406;OCCURENCE=1(biliary_tract)	SPEG	188	1	435	39	0.0822784810126582	TRUE	NA
ENSG00000115468.12	.	BCM	GRCh38.p13	chr2	232681669	232681669	+	C	C	T	Missense_Mutation	SNP	ENST00000264059.8	exon4	c.C670T	p.R224W	exonic	ENSG00000115468.12	.	nonsynonymous SNV	ENSG00000115468.12:ENST00000264059.8:exon4:c.C670T:p.R224W	2q37.1	C3L-03743	.	.	.	.	.	.	.	.	rs748253697	12.20	D	D	D	P	D	D	M	T	D	0.367	T	T	D	0.226	0.225	0.198	0.454	T	T	T	T	D	D	3.372	24.300	0.999	D	D	0.122	2.974	0.088	2.686	0.107	0.706	0.563	0.710	0.530	.	5.650	3.210	3.060	-0.104	-0.315	1.000	0.012	0.862	755	.	.	.	.	EFHD1	162	0	312	59	0.159029649595687	TRUE	NA
ENSG00000130294.16	.	BCM	GRCh38.p13	chr2	240788193	240788193	+	T	T	C	Missense_Mutation	SNP	ENST00000649096.1	exon4	c.A221G	p.Y74C	exonic	ENSG00000130294.16	.	nonsynonymous SNV	ENSG00000130294.16:ENST00000649096.1:exon4:c.A221G:p.Y74C	2q37.3	C3L-03743	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	U	D	M	D	D	0.970	D	D	D	0.916	0.741	0.948	2.533	D	D	D	D	D	D	4.131	28.000	0.998	D	D	0.889	10.763	0.767	9.224	1.000	0.672	0.547	0.702	0.613	.	4.790	4.790	6.073	1.138	0.665	1.000	0.999	0.987	.	Kinesin_motor_domain	.	.	.	KIF1A	308	0	580	93	0.138187221396731	TRUE	TRUE
ENSG00000055955.17	.	BCM	GRCh38.p13	chr3	52814272	52814272	+	C	C	T	Missense_Mutation	SNP	ENST00000266041.9	exon22	c.G2563A	p.E855K	exonic	ENSG00000055955.17	.	nonsynonymous SNV	ENSG00000055955.17:ENST00000266041.9:exon22:c.G2563A:p.E855K	3p21.1	C3L-03743	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.187	T	T	T	0.075	0.571	0.292	0.308	T	T	T	T	T	T	0.135	2.421	0.931	N	N	-1.033	0.370	-1.116	0.359	1.000	0.615	0.588	0.659	0.568	.	5.910	-7.750	-1.248	-0.251	0.599	0.000	0.002	0.984	57	Inter-alpha-trypsin_inhibitor_heavy_chain,_C-terminal	.	.	.	ITIH4	200	0	302	43	0.12463768115942	TRUE	TRUE
ENSG00000169760.17	.	BCM	GRCh38.p13	chr3	174279022	174279022	+	G	G	T	Nonsense_Mutation	SNP	ENST00000457714.5	exon6	c.G1021T	p.E341X	exonic	ENSG00000169760.17	.	stopgain	ENSG00000169760.17:ENST00000457714.5:exon6:c.G1021T:p.E341X	3q26.31	C3L-03743	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.947	.	.	.	.	.	.	.	.	.	D	D	.	.	7.542	38	0.998	D	N	1.249	29.140	1.120	29.515	1.000	0.693	0.574	0.659	0.564	.	5.760	5.760	10.003	1.176	0.618	1.000	1.000	1.000	968	Carboxylesterase,_type_B	.	.	ID=COSV100848839;OCCURENCE=1(endometrium)	NLGN1	40	0	86	10	0.104166666666667	TRUE	TRUE
ENSG00000137449.16	.	BCM	GRCh38.p13	chr4	15004070	15004070	+	C	C	T	Missense_Mutation	SNP	ENST00000538197.6	exon1	c.C1397T	p.S466L	exonic	ENSG00000137449.16	.	nonsynonymous SNV	ENSG00000137449.16:ENST00000538197.6:exon1:c.C1397T:p.S466L	4p15.32	C3L-03743	2.004e-05	0	0	0	0	3.654e-05	0	0	rs781349176	7.19	D	D	D	P	U	D	L	T	N	0.457	T	T	D	0.142	0.159	0.316	0.601	T	T	T	T	D	.	3.216	23.900	0.996	D	N	0.201	3.309	0.107	2.764	1.000	0.564	0.219	0.504	0.492	.	1.960	1.960	1.183	0.767	0.211	0.683	0.992	0.859	579	.	.	.	.	CPEB2	229	0	444	90	0.168539325842697	TRUE	NA
ENSG00000204963.6	.	BCM	GRCh38.p13	chr5	140835816	140835816	+	C	C	T	Missense_Mutation	SNP	ENST00000525929.2	exon1	c.C1433T	p.S478L	exonic	ENSG00000204963.6	.	nonsynonymous SNV	ENSG00000204963.6:ENST00000525929.2:exon1:c.C1433T:p.S478L	5q31.3	C3L-03743	.	.	.	.	.	.	.	.	.	7.19	D	D	P	P	U	D	M	T	D	0.515	T	T	T	0.113	0.459	0.707	.	.	T	T	T	D	D	2.658	22.700	0.981	N	N	-0.440	1.298	-0.606	1.037	0.009	0.554	0.588	0.555	0.613	.	4.000	2.070	0.151	0.840	0.445	0.000	0.042	0.044	31	Cadherin-like	.	.	.	PCDHA7	649	0	1199	111	0.0847328244274809	NA	TRUE
ENSG00000145882.11	.	BCM	GRCh38.p13	chr5	149368024	149368024	+	G	G	T	Missense_Mutation	SNP	ENST00000274569.9	exon6	c.G855T	p.E285D	exonic	ENSG00000145882.11	.	nonsynonymous SNV	ENSG00000145882.11:ENST00000274569.9:exon6:c.G855T:p.E285D	5q32	C3L-03743	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	N	L	T	N	0.225	T	T	T	0.035	0.328	0.289	0.601	T	T	T	T	D	T	2.161	20.600	0.967	D	N	-0.121	2.110	-0.010	2.325	1.000	0.744	0.630	0.269	0.692	.	5.530	3.720	2.591	1.176	0.676	0.998	0.728	0.452	451	Prenylcysteine_lyase	.	.	.	PCYOX1L	24	0	36	4	0.1	TRUE	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152201831	152201831	+	C	C	T	Missense_Mutation	SNP	ENST00000367255.10	exon127	c.G23138A	p.R7713H	exonic	ENSG00000131018.24	.	nonsynonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon127:c.G23138A:p.R7713H	6q25.2	C3L-03743	4.944e-05	9.61e-05	8.666e-05	0	0	0	0	0.0002	rs750911961	12.20	T	D	D	D	D	D	M	T	D	0.387	T	T	D	0.345	0.383	0.783	0.321	T	T	T	T	D	D	3.212	23.900	0.999	D	D	0.789	8.572	0.780	9.567	1.000	0.651	0.709	0.602	0.636	.	6.080	6.080	6.160	1.026	0.549	1.000	0.863	0.898	899	.	.	.	ID=COSV104542309;OCCURENCE=1(skin)	SYNE1	275	0	372	56	0.130841121495327	TRUE	NA
ENSG00000177409.12	.	BCM	GRCh38.p13	chr7	93131401	93131401	+	C	C	T	Missense_Mutation	SNP	ENST00000318238.9	exon5	c.G4571A	p.R1524H	exonic	ENSG00000177409.12	.	nonsynonymous SNV	ENSG00000177409.12:ENST00000318238.9:exon5:c.G4571A:p.R1524H	7q21.2	C3L-03743	8.267e-05	0	0	0	0	7.509e-05	0	0.0003	rs138088725	3.20	D	T	P	B	N	N	M	T	D	0.319	T	T	T	0.031	.	0.350	0.500	T	T	T	T	T	T	1.675	16.860	0.987	N	N	-0.772	0.697	-0.856	0.680	0.001	0.706	0.710	0.574	0.655	.	5.010	2.150	1.590	0.018	0.454	0.011	0.013	0.250	810	.	.	.	ID=COSV59082294;OCCURENCE=1(breast),1(endometrium)	SAMD9L	84	0	144	14	0.0886075949367089	TRUE	TRUE
ENSG00000055609.18	.	BCM	GRCh38.p13	chr7	152162220	152162220	+	G	G	A	Missense_Mutation	SNP	ENST00000262189.11	exon43	c.C11357T	p.S3786L	exonic	ENSG00000055609.18	.	nonsynonymous SNV	ENSG00000055609.18:ENST00000262189.11:exon43:c.C11357T:p.S3786L	7q36.1	C3L-03743	.	.	.	.	.	.	.	.	.	8.20	D	T	B	B	U	N	M	D	N	0.306	T	T	D	0.219	0.165	0.452	0.089	T	T	T	T	D	D	2.946	23.300	0.963	D	D	-0.018	2.447	0.100	2.734	1.000	0.707	0.725	0.609	0.636	.	5.510	5.510	7.220	1.176	0.676	1.000	0.970	0.990	804	.	.	.	.	KMT2C	72	0	132	20	0.131578947368421	TRUE	NA
ENSG00000185053.14	.	BCM	GRCh38.p13	chr8	14108199	14108199	+	G	G	A	Missense_Mutation	SNP	ENST00000382080.6	exon6	c.C584T	p.T195M	exonic	ENSG00000185053.14	.	nonsynonymous SNV	ENSG00000185053.14:ENST00000382080.6:exon6:c.C584T:p.T195M	8p22	C3L-03743	8.247e-06	0	0	0	0	1.5e-05	0	0	rs372855106	17.18	D	D	D	D	D	D	.	D	D	0.980	D	D	D	0.860	.	0.901	0.059	T	.	D	D	D	D	3.901	26.400	0.998	D	D	0.500	5.033	0.404	4.388	0.011	0.487	0.574	0.574	0.564	.	5.600	4.710	7.890	1.176	0.676	1.000	0.650	0.677	957	.	.	.	ID=COSV66007234;OCCURENCE=1(skin)	SGCZ	152	0	283	20	0.066006600660066	TRUE	NA
ENSG00000169122.11	.	BCM	GRCh38.p13	chr8	58146930	58146930	+	G	G	A	Missense_Mutation	SNP	ENST00000361488.7	exon5	c.G700A	p.A234T	exonic	ENSG00000169122.11	.	nonsynonymous SNV	ENSG00000169122.11:ENST00000361488.7:exon5:c.G700A:p.A234T	8q12.1	C3L-03743	8.24e-06	0	0	0	0	1.499e-05	0	0	rs755553412	0.20	T	T	B	B	N	N	L	T	N	0.027	T	T	T	0.014	0.210	0.061	0.646	T	T	T	T	T	T	0.248	3.684	0.845	N	N	-1.101	0.305	-1.098	0.378	1.000	0.653	0.659	0.659	0.564	.	4.380	1.390	0.700	0.066	-0.217	0.601	0.010	0.880	940	.	.	.	ID=COSV64064194;OCCURENCE=1(large_intestine),1(stomach)	FAM110B	155	0	302	18	0.05625	TRUE	TRUE
ENSG00000178860.8	.	BCM	GRCh38.p13	chr8	71842746	71842746	+	G	G	A	Missense_Mutation	SNP	ENST00000325509.4	exon2	c.C536T	p.T179I	exonic	ENSG00000178860.8	.	nonsynonymous SNV	ENSG00000178860.8:ENST00000325509.4:exon2:c.C536T:p.T179I	8q13.3	C3L-03743	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	L	D	D	0.727	D	D	D	0.799	0.461	0.863	1.277	D	T	D	D	D	D	5.059	33	0.996	D	D	0.762	8.083	0.744	8.665	1.000	0.658	0.522	0.619	0.555	.	4.880	4.880	9.757	1.176	0.676	1.000	0.994	0.997	494	.	.	.	ID=COSV57697609;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	MSC	318	0	495	92	0.156729131175468	TRUE	TRUE
ENSG00000160957.14	.	BCM	GRCh38.p13	chr8	144514941	144514941	+	C	C	A	Missense_Mutation	SNP	ENST00000617875.6	exon9	c.G1615T	p.D539Y	exonic	ENSG00000160957.14	.	nonsynonymous SNV	ENSG00000160957.14:ENST00000617875.6:exon9:c.G1615T:p.D539Y	8q24.3	C3L-03743	.	.	.	.	.	.	.	.	.	8.11	.	D	D	D	.	.	.	.	.	0.873	.	.	T	.	.	0.687	.	T	T	D	D	.	D	3.108	23.600	0.905	D	D	.	.	.	.	1.000	0.284	0.272	0.299	0.196	.	5.510	4.640	3.093	1.026	0.599	0.993	0.603	0.113	900	Helicase_superfamily_1/2,_ATP-binding_domain;DEAD/DEAH_box_helicase_domain	.	.	.	RECQL4	182	0	347	67	0.161835748792271	TRUE	TRUE
ENSG00000181001.2	.	BCM	GRCh38.p13	chr11	5788253	5788253	+	C	C	A	Missense_Mutation	SNP	ENST00000641645.1	exon2	c.G564T	p.K188N	exonic	ENSG00000181001.2	.	nonsynonymous SNV	ENSG00000181001.2:ENST00000641645.1:exon2:c.G564T:p.K188N	11p15.4	C3L-03743	.	.	.	.	.	.	.	.	.	9.20	D	D	D	D	D	D	M	T	D	0.125	T	T	T	0.151	0.475	0.456	0.244	T	T	T	T	D	T	1.245	13.980	0.998	N	N	0.111	2.928	-0.087	2.084	0.000	0.487	0.574	0.574	0.564	.	4.590	0.580	-3.145	-3.837	-0.211	0.000	0.000	0.047	729	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV100398654;OCCURENCE=1(endometrium)	OR52N1	316	1	547	92	0.143974960876369	TRUE	TRUE
ENSG00000176547.10	.	BCM	GRCh38.p13	chr11	48325062	48325062	+	G	G	A	Missense_Mutation	SNP	ENST00000319856.5	exon1	c.G41A	p.G14E	exonic	ENSG00000176547.10	.	nonsynonymous SNV	ENSG00000176547.10:ENST00000319856.5:exon1:c.G41A:p.G14E	11p11.2	C3L-03743	.	.	.	.	.	.	.	.	.	11.16	.	.	D	D	D	D	M	.	.	.	T	T	T	0.337	0.723	0.092	.	T	T	D	D	D	D	2.891	23.200	0.998	D	D	0.959	12.685	0.896	13.574	0.583	0.487	0.574	0.574	0.613	.	5.880	5.880	3.017	1.028	0.542	1.000	0.967	0.048	120	.	.	.	ID=COSV60584197;OCCURENCE=1(lung)	OR4C3	195	0	305	45	0.128571428571429	NA	TRUE
ENSG00000172500.13	.	BCM	GRCh38.p13	chr11	65887723	65887723	+	G	G	T	Nonsense_Mutation	SNP	ENST00000338369.6	exon3	c.C288A	p.Y96X	exonic	ENSG00000172500.13	.	stopgain	ENSG00000172500.13:ENST00000338369.6:exon3:c.C288A:p.Y96X	11q13.1	C3L-03743	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.491	.	.	.	.	.	.	.	.	.	D	D	.	.	6.643	36	0.994	D	N	0.375	4.194	0.196	3.166	1.000	0.628	0.686	0.672	0.639	.	4.490	2.630	2.188	-0.123	-0.671	1.000	0.975	0.822	239	.	.	.	.	FIBP	245	1	518	37	0.0666666666666667	TRUE	TRUE
ENSG00000172508.10	.	BCM	GRCh38.p13	chr11	67420753	67420753	+	G	G	A	Missense_Mutation	SNP	ENST00000307823.7	exon7	c.G889A	p.E297K	exonic	ENSG00000172508.10	.	nonsynonymous SNV	ENSG00000172508.10:ENST00000307823.7:exon7:c.G889A:p.E297K	11q13.2	C3L-03743	.	.	.	.	.	.	.	.	.	10.19	D	D	D	B	.	D	L	T	N	0.263	T	T	D	0.087	0.338	0.466	0.417	D	T	T	T	D	D	4.224	28.900	0.998	D	D	0.131	3.012	0.134	2.876	1.000	0.564	0.219	0.504	0.622	.	4.020	4.020	4.397	0.962	0.502	0.999	0.760	0.851	654	.	.	.	.	CARNS1	36	0	46	8	0.148148148148148	TRUE	TRUE
ENSG00000110237.5	.	BCM	GRCh38.p13	chr11	73363236	73363236	+	C	C	T	Missense_Mutation	SNP	ENST00000263674.4	exon15	c.C5027T	p.T1676M	exonic	ENSG00000110237.5	.	nonsynonymous SNV	ENSG00000110237.5:ENST00000263674.4:exon15:c.C5027T:p.T1676M	11q13.4	C3L-03743	.	.	.	.	.	.	.	.	rs989455757	2.20	D	T	B	B	N	N	L	T	N	0.317	T	T	T	0.041	0.201	0.378	0.403	T	T	T	T	T	T	1.704	17.060	0.977	D	N	-0.363	1.464	-0.238	1.697	1.000	0.707	0.654	0.645	0.714	.	5.180	3.300	1.716	0.126	0.599	0.853	0.875	0.934	465	.	.	.	ID=COSV55234239;OCCURENCE=1(pancreas)	ARHGEF17	85	0	186	21	0.101449275362319	TRUE	TRUE
ENSG00000033327.13	.	BCM	GRCh38.p13	chr11	78223480	78223480	+	C	C	T	Missense_Mutation	SNP	ENST00000361507.5	exon6	c.G1499A	p.R500Q	exonic	ENSG00000033327.13	.	nonsynonymous SNV	ENSG00000033327.13:ENST00000361507.5:exon6:c.G1499A:p.R500Q	11q14.1	C3L-03743	8.635e-06	0	0	0	0	1.533e-05	0	0	rs370982595	2.20	T	T	B	B	U	D	L	T	N	0.234	T	T	T	0.055	.	0.392	0.059	T	T	T	T	T	T	2.706	22.800	0.997	D	N	-0.323	1.559	-0.128	1.969	1.000	0.707	0.648	0.805	0.714	.	4.780	3.880	5.772	1.026	0.594	1.000	0.995	0.987	630	.	.	.	ID=COSV60867614;OCCURENCE=1(urinary_tract)	GAB2	49	0	78	21	0.212121212121212	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-03743	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	252	0	405	123	0.232954545454545	TRUE	TRUE
ENSG00000173208.4	.	BCM	GRCh38.p13	chr12	39604893	39604893	+	T	T	C	Missense_Mutation	SNP	ENST00000308666.4	exon4	c.A1274G	p.N425S	exonic	ENSG00000173208.4	.	nonsynonymous SNV	ENSG00000173208.4:ENST00000308666.4:exon4:c.A1274G:p.N425S	12q12	C3L-03743	.	.	.	.	.	.	.	.	.	10.20	T	T	B	B	D	D	L	D	N	0.522	D	D	D	0.346	0.503	0.946	0.497	T	T	T	T	D	D	2.361	21.900	0.946	D	D	0.048	2.686	0.238	3.374	1.000	0.732	0.744	0.574	0.621	.	5.430	5.430	7.338	1.138	0.609	1.000	1.000	0.991	794	.	.	.	.	ABCD2	87	0	141	52	0.269430051813472	TRUE	TRUE
ENSG00000133640.20	.	BCM	GRCh38.p13	chr12	85056991	85056991	+	C	C	A	Missense_Mutation	SNP	ENST00000393217.7	exon8	c.C2198A	p.T733N	exonic	ENSG00000133640.20	.	nonsynonymous SNV	ENSG00000133640.20:ENST00000393217.7:exon8:c.C2198A:p.T733N	12q21.31	C3L-03743	.	.	.	.	.	.	.	.	.	2.20	D	D	P	B	N	N	L	T	N	0.238	T	T	T	0.103	0.358	0.495	0.043	T	T	T	T	T	T	1.224	13.820	0.957	N	N	-0.245	1.755	-0.333	1.497	0.001	0.554	0.574	0.618	0.530	.	5.660	4.770	1.195	0.128	0.549	0.003	0.099	0.006	922	.	.	.	.	LRRIQ1	57	0	84	24	0.222222222222222	TRUE	TRUE
ENSG00000198838.13	.	BCM	GRCh38.p13	chr15	33838056	33838056	+	G	G	A	Missense_Mutation	SNP	ENST00000634891.1	exon89	c.G12076A	p.E4026K	exonic	ENSG00000198838.13	.	nonsynonymous SNV	ENSG00000198838.13:ENST00000634891.1:exon89:c.G12076A:p.E4026K	15q14	C3L-03743	3.312e-05	0	8.64e-05	0.0001	0	2.997e-05	0	0	rs573502706	13.19	D	.	P	B	D	D	N	D	N	0.684	D	D	D	0.678	0.577	0.892	0.232	D	T	D	D	T	D	3.140	23.700	0.998	D	D	0.284	3.697	0.368	4.140	1.000	0.554	0.574	0.602	0.568	.	5.110	5.110	4.816	1.166	0.665	1.000	0.579	0.771	830	.	.	.	ID=COSV66778841;OCCURENCE=1(breast),2(large_intestine),1(skin),2(endometrium)	RYR3	227	1	385	51	0.11697247706422	TRUE	TRUE
ENSG00000140332.17	.	BCM	GRCh38.p13	chr15	70096167	70096167	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000558939.5	exon2	c.118dupT	p.Y40Lfs*27	exonic	ENSG00000140332.17	.	frameshift insertion	ENSG00000140332.17:ENST00000558939.5:exon2:c.118dupT:p.Y40Lfs*27	15q23	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TLE3	NA	NA	NA	NA	NA	NA	NA
ENSG00000140522.12	.	BCM	GRCh38.p13	chr15	89215223	89215223	+	C	C	T	Missense_Mutation	SNP	ENST00000268125.10	exon6	c.G362A	p.R121Q	exonic	ENSG00000140522.12	.	nonsynonymous SNV	ENSG00000140522.12:ENST00000268125.10:exon6:c.G362A:p.R121Q	15q26.1	C3L-03743	2.474e-05	9.628e-05	0	0	0	3.002e-05	0	0	rs139108078	17.19	D	D	D	P	D	D	M	D	D	0.989	D	D	D	0.923	.	0.911	0.835	T	D	D	D	D	D	4.167	28.300	0.999	D	.	0.870	10.307	0.782	9.601	1.000	0.487	0.574	0.547	0.530	.	4.650	4.650	7.281	1.026	0.599	1.000	1.000	0.998	934	.	.	.	.	RLBP1	168	0	291	47	0.13905325443787	TRUE	NA
ENSG00000167984.18	.	BCM	GRCh38.p13	chr16	3564462	3564462	+	C	C	T	Missense_Mutation	SNP	ENST00000359128.10	exon5	c.G475A	p.V159I	exonic	ENSG00000167984.18	.	nonsynonymous SNV	ENSG00000167984.18:ENST00000359128.10:exon5:c.G475A:p.V159I	16p13.3	C3L-03743	8.62e-06	0	0	0	0	1.577e-05	0	0	rs750986719	3.17	T	T	.	.	D	N	.	T	N	0.114	T	T	T	0.217	0.732	0.484	.	T	T	T	T	D	T	2.064	19.740	0.996	D	N	-0.003	2.501	-0.026	2.271	0.048	0.257	0.272	0.074	0.079	.	4.930	3.990	1.997	0.077	0.599	0.928	0.694	0.991	600	NACHT_nucleoside_triphosphatase	.	.	.	NLRC3	265	0	592	52	0.0807453416149068	TRUE	NA
ENSG00000102996.5	.	BCM	GRCh38.p13	chr16	58037595	58037595	+	G	G	A	Missense_Mutation	SNP	ENST00000219271.4	exon2	c.G286A	p.G96S	exonic	ENSG00000102996.5	.	nonsynonymous SNV	ENSG00000102996.5:ENST00000219271.4:exon2:c.G286A:p.G96S	16q21	C3L-03743	.	.	.	.	.	.	.	.	rs910557137	19.20	D	D	D	D	D	D	H	D	D	0.941	D	D	D	0.902	0.888	0.951	1.217	T	D	D	D	D	D	3.735	25.500	0.999	D	D	0.773	8.267	0.580	5.981	1.000	0.696	0.590	0.723	0.655	.	3.770	3.770	9.953	1.176	0.676	1.000	0.190	0.205	602	Peptidoglycan_binding-like	.	.	ID=COSV104586469;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	MMP15	206	0	422	32	0.0704845814977974	TRUE	NA
ENSG00000140836.17	.	BCM	GRCh38.p13	chr16	72787667	72787667	+	C	C	T	Missense_Mutation	SNP	ENST00000268489.10	exon10	c.G10609A	p.A3537T	exonic	ENSG00000140836.17	.	nonsynonymous SNV	ENSG00000140836.17:ENST00000268489.10:exon10:c.G10609A:p.A3537T	16q22.2	C3L-03743	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	D	N	D	N	0.136	T	T	D	0.206	0.199	0.117	0.090	T	T	T	T	T	T	2.000	19.250	0.979	N	N	-0.545	1.090	-0.364	1.438	1.000	0.564	0.522	0.504	0.273	.	4.220	1.760	1.295	1.025	0.593	1.000	1.000	1.000	191	Zinc_finger_C2H2-type;Matrin/U1-C-like,_C2H2-type_zinc_finger	.	.	ID=COSV51738205;OCCURENCE=1(stomach)	ZFHX3	238	0	480	89	0.156414762741652	TRUE	TRUE
ENSG00000140968.11	.	BCM	GRCh38.p13	chr16	85913213	85913213	+	G	G	T	Missense_Mutation	SNP	ENST00000268638.10	exon5	c.G530T	p.W177L	exonic	ENSG00000140968.11	.	nonsynonymous SNV	ENSG00000140968.11:ENST00000268638.10:exon5:c.G530T:p.W177L	16q24.1	C3L-03743	.	.	.	.	.	.	.	.	.	12.20	D	T	B	B	N	D	L	D	N	0.676	D	D	D	0.589	0.484	0.970	1.101	T	T	D	D	D	D	3.709	25.400	0.973	D	D	0.020	2.584	0.187	3.122	1.000	0.646	0.696	0.602	0.542	.	4.860	4.860	7.622	1.176	0.676	1.000	1.000	0.999	969	Interferon_regulatory_factor_DNA-binding_domain	.	.	.	IRF8	329	0	660	60	0.0833333333333333	TRUE	TRUE
ENSG00000225614.4	.	BCM	GRCh38.p13	chr16	88434539	88434539	+	G	G	A	Missense_Mutation	SNP	ENST00000565624.3	exon3	c.G7069A	p.G2357S	exonic	ENSG00000225614.4	.	nonsynonymous SNV	ENSG00000225614.4:ENST00000565624.3:exon3:c.G7069A:p.G2357S	16q24.2	C3L-03743	.	.	.	.	.	.	.	.	.	1.16	T	T	.	.	.	N	.	T	N	0.046	T	T	D	0.007	0.255	0.220	.	T	T	T	T	T	T	0.241	3.593	0.391	N	N	-1.354	0.137	-1.431	0.137	0.337	0.615	0.588	0.576	0.655	.	3.900	-3.670	-0.388	-0.182	0.618	0.000	0.000	0.001	.	.	.	.	.	ZNF469	188	0	417	41	0.0895196506550218	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673776	7673776	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.C844T	p.R282W	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.C844T:p.R282W	17p13.1	C3L-03743	1.659e-05	0	0	0	0	3.014e-05	0	0	rs28934574	19.20	D	D	D	D	D	A	M	D	D	0.932	D	D	D	0.896	.	0.980	0.392	T	D	D	D	D	D	4.401	31	0.999	D	D	0.395	4.315	0.222	3.292	0.203	0.722	0.702	0.725	0.735	.	4.750	1.490	4.023	1.172	0.672	1.000	0.519	0.997	432	p53,_DNA-binding_domain	.	.	ID=COSV52662048;OCCURENCE=1(salivary_gland),52(breast),2(peritoneum),6(liver),92(oesophagus),1(cervix),279(large_intestine),54(central_nervous_system),12(biliary_tract),1(pleura),6(vulva),25(ovary),3(bone),2(NS),20(haematopoietic_and_lymphoid_tissue),64(stomach),5(kidney),3(soft_tissue),22(urinary_tract),48(pancreas),21(skin),21(prostate),38(lung),6(thyroid),78(upper_aerodigestive_tract),3(thymus),3(small_intestine),13(endometrium)	TP53	596	0	744	167	0.183315038419319	TRUE	TRUE
ENSG00000278540.5	.	BCM	GRCh38.p13	chr17	37243454	37243454	+	T	T	C	Missense_Mutation	SNP	ENST00000614428.4	exon22	c.A2737G	p.N913D	exonic	ENSG00000278540.5	.	nonsynonymous SNV	ENSG00000278540.5:ENST00000614428.4:exon22:c.A2737G:p.N913D	17q12	C3L-03743	.	.	.	.	.	.	.	.	.	4.16	.	T	B	B	D	D	N	.	.	0.312	T	T	T	0.061	0.539	0.266	.	T	T	T	T	D	.	2.214	21.000	0.994	D	N	-0.214	1.837	-0.037	2.236	0.023	0.707	0.654	0.725	0.714	.	4.900	4.900	2.287	1.138	0.665	1.000	0.998	0.961	657	Acetyl-CoA_carboxylase,_central_domain	.	.	.	ACACA	195	1	362	80	0.180995475113122	TRUE	TRUE
ENSG00000171345.13	.	BCM	GRCh38.p13	chr17	41528058	41528069	+	CGCCGCCGTAGG	CGCCGCCGTAGG	-	In_Frame_Del	DEL	ENST00000361566.7	exon1	c.179_190del	p.A60_G63del	exonic	ENSG00000171345.13	.	nonframeshift deletion	ENSG00000171345.13:ENST00000361566.7:exon1:c.179_190del:p.A60_G63del	17q21.2	C3L-03743	0.0004	0.0010	0.0003	0	0.0005	0.0004	0.0012	0	rs781617871	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KRT19	288	0	621	65	0.0947521865889213	NA	TRUE
ENSG00000141449.14	.	BCM	GRCh38.p13	chr18	21500143	21500143	+	G	G	A	Missense_Mutation	SNP	ENST00000580732.6	exon22	c.G3806A	p.R1269Q	exonic	ENSG00000141449.14	.	nonsynonymous SNV	ENSG00000141449.14:ENST00000580732.6:exon22:c.G3806A:p.R1269Q	18q11.2	C3L-03743	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.780	T	T	D	0.348	0.798	0.253	.	T	T	D	T	D	D	3.934	26.500	1.000	D	D	0.738	7.691	0.670	7.221	1.000	0.615	0.588	0.602	0.655	.	4.440	4.440	8.999	1.176	0.676	1.000	0.862	0.714	402	.	.	.	.	GREB1L	217	0	592	41	0.0647709320695103	TRUE	NA
ENSG00000134490.14	.	BCM	GRCh38.p13	chr18	23373759	23373759	+	G	G	C	Missense_Mutation	SNP	ENST00000383233.8	exon7	c.C388G	p.L130V	exonic	ENSG00000134490.14	.	nonsynonymous SNV	ENSG00000134490.14:ENST00000383233.8:exon7:c.C388G:p.L130V	18q11.2	C3L-03743	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	L	T	N	0.149	T	T	T	0.030	0.346	0.696	0.093	T	T	T	T	T	T	1.674	16.850	0.929	D	N	-0.136	2.064	-0.100	2.048	0.952	0.742	0.654	0.775	0.636	.	5.990	1.980	1.191	0.210	-0.111	0.968	0.999	0.970	860	.	.	.	.	TMEM241	121	0	183	40	0.179372197309417	TRUE	TRUE
ENSG00000142303.14	.	BCM	GRCh38.p13	chr19	8603775	8603775	+	C	C	T	Missense_Mutation	SNP	ENST00000597188.6	exon5	c.G545A	p.R182H	exonic	ENSG00000142303.14	.	nonsynonymous SNV	ENSG00000142303.14:ENST00000597188.6:exon5:c.G545A:p.R182H	19p13.2	C3L-03743	8.246e-06	0	8.657e-05	0	0	0	0	0	rs782567931	11.16	T	D	.	.	D	D	.	T	D	0.785	T	T	D	0.355	0.538	0.564	1.759	D	.	T	D	D	D	3.956	26.700	1.000	D	D	0.602	5.944	0.644	6.819	1.000	0.635	0.574	0.644	0.655	.	5.720	5.720	4.528	0.996	0.545	1.000	0.998	0.982	840	.	.	.	ID=COSV54351680;OCCURENCE=1(large_intestine),3(kidney),1(prostate)	ADAMTS10	224	0	382	66	0.147321428571429	TRUE	TRUE
ENSG00000126246.10	.	BCM	GRCh38.p13	chr19	35739740	35739740	+	C	C	A	Nonsense_Mutation	SNP	ENST00000246532.6	exon4	c.G691T	p.E231X	exonic	ENSG00000126246.10	.	stopgain	ENSG00000126246.10:ENST00000246532.6:exon4:c.G691T:p.E231X	19q13.12	C3L-03743	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	U	D	.	.	.	0.028	.	.	.	.	.	.	.	.	.	D	D	.	.	5.872	35	0.976	N	N	-0.076	2.252	-0.464	1.261	1.000	0.726	0.686	0.594	0.604	.	4.650	-1.630	-0.690	1.000	0.599	0.000	0.008	0.004	698	.	.	.	.	IGFLR1	25	0	45	16	0.262295081967213	TRUE	TRUE
ENSG00000124126.14	.	BCM	GRCh38.p13	chr20	48666319	48666319	+	C	C	T	Missense_Mutation	SNP	ENST00000371941.4	exon15	c.G1702A	p.G568S	exonic	ENSG00000124126.14	.	nonsynonymous SNV	ENSG00000124126.14:ENST00000371941.4:exon15:c.G1702A:p.G568S	20q13.13	C3L-03743	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	U	D	M	T	D	0.857	T	T	D	0.433	0.715	0.672	2.213	D	T	D	T	D	D	3.592	25.000	0.999	D	D	0.891	10.817	0.803	10.227	1.000	0.706	0.698	0.710	0.714	.	5.070	5.070	7.530	1.026	0.597	1.000	0.878	0.224	889	DEP_domain	.	.	ID=COSV100906632;OCCURENCE=1(stomach)	PREX1	215	0	449	64	0.124756335282651	TRUE	TRUE
ENSG00000087460.25	.	BCM	GRCh38.p13	chr20	58854836	58854836	+	G	G	A	Missense_Mutation	SNP	ENST00000371100.8	exon1	c.G1571A	p.R524H	exonic	ENSG00000087460.25	.	nonsynonymous SNV	ENSG00000087460.25:ENST00000371100.8:exon1:c.G1571A:p.R524H	20q13.32	C3L-03743	9.858e-05	0	0	0.0008	0	0	0	0.0002	rs745875776	5.20	D	T	D	B	N	N	L	D	N	0.181	T	D	D	0.338	0.393	0.344	0.530	T	T	T	T	T	T	1.442	15.360	0.983	N	N	-0.774	0.693	-0.945	0.560	1.000	0.598	0.627	0.504	0.639	.	3.070	1.030	-0.679	-1.193	-0.279	0.000	0.023	0.249	959	.	.	.	ID=COSV58331713;OCCURENCE=3(large_intestine)	GNAS	377	0	707	145	0.17018779342723	TRUE	TRUE
ENSG00000125510.18	.	BCM	GRCh38.p13	chr20	64098561	64098561	+	C	C	T	Missense_Mutation	SNP	ENST00000336866.7	exon5	c.C875T	p.P292L	exonic	ENSG00000125510.18	.	nonsynonymous SNV	ENSG00000125510.18:ENST00000336866.7:exon5:c.C875T:p.P292L	20q13.33	C3L-03743	1.67e-05	0.0002	0	0	0	0	0	0	rs147804138	4.20	T	T	B	B	D	D	N	T	N	0.073	T	T	D	0.153	.	0.354	0.555	T	T	T	T	T	T	1.548	16.040	0.972	D	N	-0.290	1.639	-0.176	1.846	1.000	0.615	0.588	0.659	0.586	.	5.050	4.100	1.142	0.992	0.578	0.246	0.109	0.062	.	GPCR,_rhodopsin-like,_7TM	.	.	.	OPRL1	257	1	502	55	0.0987432675044883	TRUE	NA
ENSG00000198223.16	.	BCM	GRCh38.p13	chrX	1288852	1288852	+	G	G	A	Missense_Mutation	SNP	ENST00000381524.8	exon6	c.G437A	p.R146H	exonic	ENSG00000198223.16	.	nonsynonymous SNV	ENSG00000198223.16:ENST00000381524.8:exon6:c.G437A:p.R146H	Xp22.33	C3L-03743	4.948e-05	0	0.0003	0	0	1.498e-05	0	0.0001	rs759083963	2.19	T	T	B	B	U	N	L	D	N	0.322	T	D	T	0.214	0.621	0.706	0.151	T	T	T	T	T	T	-0.184	0.553	0.901	N	.	.	.	.	.	0.995	.	.	.	.	.	2.020	-4.040	-0.981	-0.800	-1.109	0.000	0.002	0.001	.	Type_I_cytokine_receptor,_cytokine-binding_domain;Short_hematopoietin_receptor,_family_2,_conserved_site	.	.	ID=COSV62624542;OCCURENCE=1(ovary)	CSF2RA	361	0	554	61	0.0991869918699187	TRUE	TRUE
ENSG00000171004.18	.	BCM	GRCh38.p13	chrX	132958562	132958562	+	G	G	A	Missense_Mutation	SNP	ENST00000370836.6	exon2	c.C41T	p.P14L	exonic	ENSG00000171004.18	.	nonsynonymous SNV	ENSG00000171004.18:ENST00000370836.6:exon2:c.C41T:p.P14L	Xq26.2	C3L-03743	6.543e-05	0.0008	0	0	0	0	0	0	rs780044877	4.19	D	D	P	B	N	D	N	T	N	0.451	T	T	D	0.333	0.190	0.806	1.032	T	T	T	T	T	T	3.543	24.800	0.997	N	.	.	.	.	.	1.000	.	.	.	.	.	3.790	2.910	2.541	0.212	-0.153	0.998	0.988	0.493	628	.	.	.	ID=COSV63718619;OCCURENCE=1(thyroid)	HS6ST2	103	0	214	16	0.0695652173913043	TRUE	TRUE
ENSG00000183837.9	.	BCM	GRCh38.p13	chrX	153057684	153057684	+	G	G	A	Missense_Mutation	SNP	ENST00000593810.2	exon1	c.G629A	p.R210Q	exonic	ENSG00000183837.9	.	nonsynonymous SNV	ENSG00000183837.9:ENST00000593810.2:exon1:c.G629A:p.R210Q	Xq28	C3L-03743	.	.	.	.	.	.	.	.	.	5.16	.	D	D	D	.	N	M	T	.	0.144	T	T	T	0.054	0.509	0.195	.	T	T	T	T	T	D	0.751	8.924	0.997	N	.	.	.	.	.	0.020	.	.	.	.	.	1.980	1.100	0.098	1.141	0.612	0.000	0.011	0.462	77	.	.	.	.	PNMA3	311	0	604	48	0.0736196319018405	TRUE	NA
ENSG00000180879.14	.	BCM	GRCh38.p13	chrX	153797752	153797752	+	G	G	A	Missense_Mutation	SNP	ENST00000370086.8	exon4	c.G289A	p.A97T	exonic	ENSG00000180879.14	.	nonsynonymous SNV	ENSG00000180879.14:ENST00000370086.8:exon4:c.G289A:p.A97T	Xq28	C3L-03743	.	.	.	.	.	.	.	.	.	10.19	T	T	D	P	D	D	M	T	D	0.603	T	T	D	0.402	0.701	0.787	0.664	T	T	D	D	D	T	2.561	22.600	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.600	5.600	7.248	1.175	0.676	1.000	0.589	0.066	65	.	.	.	.	SSR4	245	0	495	39	0.0730337078651685	TRUE	NA
ENSG00000075539.15	.	BCM	GRCh38.p13	chr4	48521047	48521047	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000075539.15	ENST00000358350.9:exon55:c.7689+1G>A	.	.	4p11	C3L-03743	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.030	33	0.994	D	.	1.152	20.175	1.003	19.039	1.000	0.156	0.156	0.126	0.118	0.985	5.610	5.610	7.568	1.026	0.599	1.000	0.998	0.909	132	.	.	.	.	FRYL	58	0	109	13	0.10655737704918	TRUE	TRUE
ENSG00000113569.16	.	BCM	GRCh38.p13	chr5	37341089	37341089	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000113569.16	ENST00000231498.8:exon11:c.1246+1G>T	.	.	5p13.2	C3L-03743	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.578	34	0.995	D	.	1.173	21.528	1.028	20.683	1.000	0.099	0.105	0.138	0.118	0.990	5.430	5.430	7.196	1.026	0.549	1.000	1.000	0.996	174	.	.	.	.	NUP155	167	0	322	43	0.117808219178082	TRUE	TRUE
ENSG00000187642.9	.	BCM	GRCh38.p13	chr1	979122	979122	+	C	C	T	Silent	SNP	ENST00000433179.3	exon1	c.G1908A	p.P636P	exonic	ENSG00000187642.9	.	synonymous SNV	ENSG00000187642.9:ENST00000433179.3:exon1:c.G1908A:p.P636P	1p36.33	C3L-03743	6.96e-05	0	0	0	0	0.0002	0	0	rs759972334	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100378962;OCCURENCE=1(large_intestine)	PERM1	99	0	220	30	0.12	TRUE	NA
ENSG00000179403.12	.	BCM	GRCh38.p13	chr1	1439640	1439640	+	C	C	T	Silent	SNP	ENST00000476993.2	exon3	c.C1191T	p.T397T	exonic	ENSG00000179403.12	.	synonymous SNV	ENSG00000179403.12:ENST00000476993.2:exon3:c.C1191T:p.T397T	1p36.33	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VWA1	85	0	256	29	0.101754385964912	TRUE	NA
ENSG00000183317.17	.	BCM	GRCh38.p13	chr1	37731454	37731454	+	G	G	T	Silent	SNP	ENST00000373048.9	exon7	c.C1620A	p.A540A	exonic	ENSG00000183317.17	.	synonymous SNV	ENSG00000183317.17:ENST00000373048.9:exon7:c.C1620A:p.A540A	1p34.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EPHA10	98	0	171	18	0.0952380952380952	TRUE	TRUE
ENSG00000189181.5	.	BCM	GRCh38.p13	chr1	248681846	248681846	+	G	G	A	Silent	SNP	ENST00000342623.5	exon1	c.C459T	p.Y153Y	exonic	ENSG00000189181.5	.	synonymous SNV	ENSG00000189181.5:ENST00000342623.5:exon1:c.C459T:p.Y153Y	1q44	C3L-03743	9.071e-05	0	0.0002	0.0003	0	2.999e-05	0	0.0002	rs200035502	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61199435;OCCURENCE=1(large_intestine),1(lung)	OR14I1	165	0	280	26	0.0849673202614379	TRUE	TRUE
ENSG00000155052.14	.	BCM	GRCh38.p13	chr2	124902892	124902892	+	T	T	C	Silent	SNP	ENST00000431078.1	exon22	c.T3444C	p.G1148G	exonic	ENSG00000155052.14	.	synonymous SNV	ENSG00000155052.14:ENST00000431078.1:exon22:c.T3444C:p.G1148G	2q14.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNTNAP5	58	0	125	10	0.0740740740740741	TRUE	TRUE
ENSG00000144821.10	.	BCM	GRCh38.p13	chr3	108414411	108414411	+	G	G	T	Silent	SNP	ENST00000273353.4	exon31	c.C4026A	p.A1342A	exonic	ENSG00000144821.10	.	synonymous SNV	ENSG00000144821.10:ENST00000273353.4:exon31:c.C4026A:p.A1342A	3q13.13	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYH15	100	0	237	16	0.0632411067193676	TRUE	TRUE
ENSG00000206260.4	.	BCM	GRCh38.p13	chr3	139006230	139006230	+	C	C	T	Silent	SNP	ENST00000383163.4	exon1	c.G39A	p.A13A	exonic	ENSG00000206260.4	.	synonymous SNV	ENSG00000206260.4:ENST00000383163.4:exon1:c.G39A:p.A13A	3q23	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101270305;OCCURENCE=1(oesophagus)	PRR23A	207	0	509	29	0.0539033457249071	NA	TRUE
ENSG00000138741.11	.	BCM	GRCh38.p13	chr4	121932481	121932481	+	G	G	A	Silent	SNP	ENST00000379645.8	exon2	c.C777T	p.I259I	exonic	ENSG00000138741.11	.	synonymous SNV	ENSG00000138741.11:ENST00000379645.8:exon2:c.C777T:p.I259I	4q27	C3L-03743	.	.	.	.	.	.	.	.	rs201449030	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53373268;OCCURENCE=1(large_intestine)	TRPC3	311	0	586	56	0.0872274143302181	TRUE	TRUE
ENSG00000066230.12	.	BCM	GRCh38.p13	chr5	479953	479953	+	G	G	A	Silent	SNP	ENST00000264938.8	exon10	c.C1530T	p.F510F	exonic	ENSG00000066230.12	.	synonymous SNV	ENSG00000066230.12:ENST00000264938.8:exon10:c.C1530T:p.F510F	5p15.33	C3L-03743	8.276e-06	9.638e-05	0	0	0	0	0	0	rs369450763	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99375525;OCCURENCE=1(breast),1(endometrium)	SLC9A3	131	0	270	19	0.0657439446366782	TRUE	NA
ENSG00000112964.14	.	BCM	GRCh38.p13	chr5	42718959	42718959	+	C	C	T	Silent	SNP	ENST00000230882.9	exon10	c.C1452T	p.I484I	exonic	ENSG00000112964.14	.	synonymous SNV	ENSG00000112964.14:ENST00000230882.9:exon10:c.C1452T:p.I484I	5p12	C3L-03743	8.283e-06	0	0	0	0	1.503e-05	0	0	rs778616140	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50111829;OCCURENCE=1(endometrium)	GHR	122	1	169	33	0.163366336633663	TRUE	TRUE
ENSG00000248383.4	.	BCM	GRCh38.p13	chr5	140928551	140928551	+	G	G	A	Silent	SNP	ENST00000253807.2	exon1	c.G1659A	p.P553P	exonic	ENSG00000248383.4	.	synonymous SNV	ENSG00000248383.4:ENST00000253807.2:exon1:c.G1659A:p.P553P	5q31.3	C3L-03743	8.239e-06	0	0	0	0.0002	0	0	0	rs782615304	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99167542;OCCURENCE=1(endometrium)	PCDHAC1	191	0	334	32	0.087431693989071	TRUE	NA
ENSG00000113212.7	.	BCM	GRCh38.p13	chr5	141174575	141174575	+	C	C	T	Silent	SNP	ENST00000231137.6	exon1	c.C1740T	p.A580A	exonic	ENSG00000113212.7	.	synonymous SNV	ENSG00000113212.7:ENST00000231137.6:exon1:c.C1740T:p.A580A	5q31.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99177223;OCCURENCE=1(endometrium)	PCDHB7	924	1	1479	251	0.145086705202312	NA	TRUE
ENSG00000137285.10	.	BCM	GRCh38.p13	chr6	3225399	3225399	+	C	C	T	Silent	SNP	ENST00000259818.8	exon4	c.G690A	p.S230S	exonic	ENSG00000137285.10	.	synonymous SNV	ENSG00000137285.10:ENST00000259818.8:exon4:c.G690A:p.S230S	6p25.2	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TUBB2B	320	0	509	82	0.138747884940778	NA	TRUE
ENSG00000146828.18	.	BCM	GRCh38.p13	chr7	100858896	100858896	+	C	C	T	Silent	SNP	ENST00000354161.8	exon6	c.C819T	p.V273V	exonic	ENSG00000146828.18	.	synonymous SNV	ENSG00000146828.18:ENST00000354161.8:exon6:c.C819T:p.V273V	7q22.1	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC12A9	215	1	544	40	0.0684931506849315	TRUE	TRUE
ENSG00000236279.7	.	BCM	GRCh38.p13	chr7	139542080	139542080	+	C	C	T	Silent	SNP	ENST00000422142.7	exon4	c.C492T	p.D164D	exonic	ENSG00000236279.7	.	synonymous SNV	ENSG00000236279.7:ENST00000422142.7:exon4:c.C492T:p.D164D	7q34	C3L-03743	9.766e-06	0	0	0.0001	0	0	0	0	rs547876426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV70691354;OCCURENCE=1(large_intestine)	CLEC2L	216	0	378	40	0.0956937799043062	TRUE	TRUE
ENSG00000168453.15	.	BCM	GRCh38.p13	chr8	22128598	22128598	+	G	G	A	Silent	SNP	ENST00000381418.9	exon2	c.C573T	p.G191G	exonic	ENSG00000168453.15	.	synonymous SNV	ENSG00000168453.15:ENST00000381418.9:exon2:c.C573T:p.G191G	8p21.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HR	359	0	473	123	0.206375838926175	TRUE	TRUE
ENSG00000091656.19	.	BCM	GRCh38.p13	chr8	76704481	76704481	+	C	C	T	Silent	SNP	ENST00000651372.2	exon2	c.C393T	p.I131I	exonic	ENSG00000091656.19	.	synonymous SNV	ENSG00000091656.19:ENST00000651372.2:exon2:c.C393T:p.I131I	8q21.13	C3L-03743	0.0004	0	0.0006	0	0	0.0003	0.0011	0.0016	rs187480056	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50809903;OCCURENCE=1(large_intestine),3(skin)	ZFHX4	227	0	430	25	0.0549450549450549	TRUE	TRUE
ENSG00000070756.16	.	BCM	GRCh38.p13	chr8	100706891	100706891	+	A	A	G	Silent	SNP	ENST00000318607.10	exon10	c.T1443C	p.R481R	exonic	ENSG00000070756.16	.	synonymous SNV	ENSG00000070756.16:ENST00000318607.10:exon10:c.T1443C:p.R481R	8q22.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PABPC1	219	0	442	33	0.0694736842105263	TRUE	TRUE
ENSG00000064218.5	.	BCM	GRCh38.p13	chr9	977193	977193	+	G	G	T	Silent	SNP	ENST00000190165.3	exon1	c.G192T	p.R64R	exonic	ENSG00000064218.5	.	synonymous SNV	ENSG00000064218.5:ENST00000190165.3:exon1:c.G192T:p.R64R	9p24.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DMRT3	266	0	420	57	0.119496855345912	TRUE	TRUE
ENSG00000083067.22	.	BCM	GRCh38.p13	chr9	70625239	70625239	+	C	C	T	Silent	SNP	ENST00000357533.6	exon14	c.G1767A	p.T589T	exonic	ENSG00000083067.22	.	synonymous SNV	ENSG00000083067.22:ENST00000357533.6:exon14:c.G1767A:p.T589T	9q21.12	C3L-03743	8.303e-06	0	0	0	0	1.508e-05	0	0	rs763892148	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRPM3	256	0	522	95	0.153970826580227	TRUE	NA
ENSG00000095596.12	.	BCM	GRCh38.p13	chr10	93076612	93076612	+	C	C	T	Silent	SNP	ENST00000224356.5	exon6	c.C1068T	p.I356I	exonic	ENSG00000095596.12	.	synonymous SNV	ENSG00000095596.12:ENST00000224356.5:exon6:c.C1068T:p.I356I	10q23.33	C3L-03743	4.12e-05	0	0	0.0001	0	0	0	0.0002	rs771602770	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56418195;OCCURENCE=1(large_intestine)	CYP26A1	102	0	149	27	0.153409090909091	TRUE	TRUE
ENSG00000061987.16	.	BCM	GRCh38.p13	chr12	62592665	62592665	+	C	C	T	Silent	SNP	ENST00000393630.8	exon35	c.C5070T	p.V1690V	exonic	ENSG00000061987.16	.	synonymous SNV	ENSG00000061987.16:ENST00000393630.8:exon35:c.C5070T:p.V1690V	12q14.1	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MON2	62	0	115	12	0.094488188976378	TRUE	TRUE
ENSG00000136099.13	.	BCM	GRCh38.p13	chr13	52848050	52848050	+	G	G	A	Silent	SNP	ENST00000377942.7	exon1	c.C387T	p.N129N	exonic	ENSG00000136099.13	.	synonymous SNV	ENSG00000136099.13:ENST00000377942.7:exon1:c.C387T:p.N129N	13q14.3	C3L-03743	.	.	.	.	.	.	.	.	rs200833172	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDH8	167	0	347	28	0.0746666666666667	TRUE	NA
ENSG00000198542.14	.	BCM	GRCh38.p13	chr13	101454093	101454093	+	C	C	G	Silent	SNP	ENST00000376180.8	exon2	c.C309G	p.T103T	exonic	ENSG00000198542.14	.	synonymous SNV	ENSG00000198542.14:ENST00000376180.8:exon2:c.C309G:p.T103T	13q33.1	C3L-03743	.	.	.	.	.	.	.	.	.	3.11	.	D	.	.	.	D	.	.	.	0.172	T	T	.	0.044	.	0.299	.	.	T	T	T	T	T	1.046	12.180	0.810	D	N	-0.017	2.452	0.009	2.390	1.000	0.493	0.476	0.596	0.628	.	5.800	3.090	-0.090	0.125	-0.190	0.726	0.965	0.934	951	.	.	.	.	ITGBL1	129	0	259	63	0.195652173913043	TRUE	NA
ENSG00000132613.15	.	BCM	GRCh38.p13	chr16	70663941	70663941	+	G	G	A	Silent	SNP	ENST00000338779.11	exon15	c.C1980T	p.A660A	exonic	ENSG00000132613.15	.	synonymous SNV	ENSG00000132613.15:ENST00000338779.11:exon15:c.C1980T:p.A660A	16q22.1	C3L-03743	0	0	0	0	0	0	0	0	rs568672711	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MTSS2	284	0	660	51	0.0717299578059072	TRUE	NA
ENSG00000007237.18	.	BCM	GRCh38.p13	chr17	9959238	9959238	+	C	C	T	Silent	SNP	ENST00000432992.6	exon5	c.G489A	p.S163S	exonic	ENSG00000007237.18	.	synonymous SNV	ENSG00000007237.18:ENST00000432992.6:exon5:c.G489A:p.S163S	17p13.1	C3L-03743	0.0004	0.0002	0.0004	0	0	0.0006	0	0.0002	rs142589082	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60432134;OCCURENCE=1(large_intestine),1(endometrium)	GAS7	130	0	215	29	0.118852459016393	TRUE	TRUE
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8135977	8135977	+	G	G	A	Silent	SNP	ENST00000600128.6	exon13	c.C1575T	p.D525D	exonic	ENSG00000142449.13	.	synonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon13:c.C1575T:p.D525D	19p13.2	C3L-03743	0.0164	0.1075	0.0170	0	0	0.0024	0.0095	0.0008	rs80125054	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54453740;OCCURENCE=1(oesophagus)	FBN3	229	1	395	36	0.0835266821345708	TRUE	TRUE
ENSG00000075702.18	.	BCM	GRCh38.p13	chr19	36086703	36086703	+	C	C	A	Silent	SNP	ENST00000270301.11	exon13	c.C1659A	p.A553A	exonic	ENSG00000075702.18	.	synonymous SNV	ENSG00000075702.18:ENST00000270301.11:exon13:c.C1659A:p.A553A	19q13.12	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WDR62	471	0	1058	86	0.0751748251748252	TRUE	TRUE
ENSG00000249861.4	.	BCM	GRCh38.p13	chr19	39660475	39660475	+	A	A	G	Silent	SNP	ENST00000392051.4	exon4	c.A384G	p.R128R	exonic	ENSG00000249861.4	.	synonymous SNV	ENSG00000249861.4:ENST00000392051.4:exon4:c.A384G:p.R128R	19q13.2	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LGALS16	216	0	271	113	0.294270833333333	TRUE	TRUE
ENSG00000126464.14	.	BCM	GRCh38.p13	chr19	49599757	49599757	+	C	C	T	Silent	SNP	ENST00000418929.7	exon5	c.C4164T	p.V1388V	exonic	ENSG00000126464.14	.	synonymous SNV	ENSG00000126464.14:ENST00000418929.7:exon5:c.C4164T:p.V1388V	19q13.33	C3L-03743	.	.	.	.	.	.	.	.	rs752042891	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV69816723;OCCURENCE=1(liver)	PRR12	287	0	685	37	0.0512465373961219	TRUE	NA
ENSG00000142513.6	.	BCM	GRCh38.p13	chr19	50794945	50794945	+	T	T	C	Silent	SNP	ENST00000270593.2	exon10	c.T1146C	p.Y382Y	exonic	ENSG00000142513.6	.	synonymous SNV	ENSG00000142513.6:ENST00000270593.2:exon10:c.T1146C:p.Y382Y	19q13.33	C3L-03743	6.705e-05	0	0	0	0	0	0	0.0005	rs773944011	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACP4	106	0	161	91	0.361111111111111	TRUE	NA
ENSG00000125831.10	.	BCM	GRCh38.p13	chr20	23451849	23451849	+	C	C	T	Silent	SNP	ENST00000377009.8	exon2	c.G300A	p.T100T	exonic	ENSG00000125831.10	.	synonymous SNV	ENSG00000125831.10:ENST00000377009.8:exon2:c.G300A:p.T100T	20p11.21	C3L-03743	3.298e-05	0	0	0	0.0003	1.5e-05	0	6.069e-05	rs770430472	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65440441;OCCURENCE=1(large_intestine),1(bone),1(NS),1(pancreas),4(skin)	CST11	90	0	144	29	0.167630057803468	TRUE	TRUE
ENSG00000100426.7	.	BCM	GRCh38.p13	chr22	49886404	49886404	+	C	C	T	Silent	SNP	ENST00000216268.6	exon2	c.C2742T	p.V914V	exonic	ENSG00000100426.7	.	synonymous SNV	ENSG00000100426.7:ENST00000216268.6:exon2:c.C2742T:p.V914V	22q13.33	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53464482;OCCURENCE=1(endometrium)	ZBED4	33	0	60	4	0.0625	TRUE	TRUE
ENSG00000135842.17	.	BCM	GRCh38.p13	chr1	184808011	184808011	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000135842.17	.	.	.	1q25.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NIBAN1	156	0	231	54	0.189473684210526	TRUE	NA
ENSG00000105889.15	.	BCM	GRCh38.p13	chr7	22438686	22438686	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000105889.15	.	.	.	7p15.3	C3L-03743	.	.	.	.	.	.	.	.	.	0.15	T	T	.	.	.	N	.	T	N	0.042	T	T	T	0.028	0.175	0.014	1.336	T	.	T	T	T	T	-0.044	1.083	0.068	N	N	-1.238	0.201	-1.288	0.217	0.999	0.615	0.492	0.602	0.655	.	0.982	0.982	-0.227	0.830	0.545	0.000	0.018	0.004	926	.	.	.	.	STEAP1B	243	1	418	88	0.173913043478261	TRUE	TRUE
ENSG00000036448.10	.	BCM	GRCh38.p13	chr8	2201166	2201166	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000036448.10;ENSG00000253444.1	dist=55710;dist=292710	.	.	8p23.3	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYOM2	463	1	736	61	0.0765370138017566	TRUE	NA
ENSG00000222468.1	.	BCM	GRCh38.p13	chr8	31640287	31640287	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000222468.1;ENSG00000286648.1	dist=42083;dist=186951	.	.	8p12	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNA5SP261	14	0	27	5	0.15625	TRUE	TRUE
ENSG00000066827.16	.	BCM	GRCh38.p13	chr8	134510062	134510062	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000066827.16	.	.	.	8q24.22	C3L-03743	.	.	.	.	.	.	.	.	.	1.12	D	T	.	.	.	N	.	.	N	.	T	T	.	0.023	0.264	0.092	.	.	.	T	T	T	T	0.261	3.832	0.857	N	N	-1.087	0.318	-1.275	0.226	0.995	0.487	0.573	0.574	0.564	.	4.010	-3.160	0.155	-0.665	-1.117	0.000	0.000	0.000	964	.	.	.	.	ZFAT	138	0	287	65	0.184659090909091	TRUE	NA
ENSG00000254872.3	.	BCM	GRCh38.p13	chr11	1100770	1100770	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000254872.3;ENSG00000198788.8	dist=45021;dist=1685	.	.	11p15.5	C3L-03743	8.998e-05	0.0003	8.78e-05	0.0001	0	0	0	0.0004	rs368859604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC02688	30	0	58	19	0.246753246753247	TRUE	NA
ENSG00000170608.3	.	BCM	GRCh38.p13	chr19	45864456	45864456	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000170608.3	ENST00000302177.3:c.-1G>A	.	.	19q13.32	C3L-03743	5.847e-05	0	0	0	0	0.0001	0	0	rs776599578	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FOXA3	22	0	49	21	0.3	TRUE	NA
ENSG00000167077.13	.	BCM	GRCh38.p13	chr22	41793914	41793914	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000167077.13	.	.	.	22q13.2	C3L-03743	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MEI1	184	0	336	23	0.064066852367688	TRUE	NA
ENSG00000198483.13	.	BCM	GRCh38.p13	chr1	145873063	145873063	+	C	C	T	Missense_Mutation	SNP	ENST00000355594.9	exon10	c.G1706A	p.G569E	exonic	ENSG00000198483.13	.	nonsynonymous SNV	ENSG00000198483.13:ENST00000355594.9:exon10:c.G1706A:p.G569E	1q21.1	C3N-00511	.	.	.	.	.	.	.	.	.	0.7	T	T	.	.	.	.	.	T	N	0.071	.	.	.	.	.	.	.	.	T	.	.	.	T	0.859	9.994	.	.	N	.	.	.	.	.	.	.	.	.	.	.	.	0.185	1.022	0.596	0.000	0.951	0.976	.	.	.	.	ID=COSV100841784;OCCURENCE=1(skin)	ANKRD35	64	1	155	46	0.228855721393035	TRUE	TRUE
ENSG00000143190.23	.	BCM	GRCh38.p13	chr1	167396359	167396359	+	C	C	G	Missense_Mutation	SNP	ENST00000541643.7	exon11	c.C992G	p.A331G	exonic	ENSG00000143190.23	.	nonsynonymous SNV	ENSG00000143190.23:ENST00000541643.7:exon11:c.C992G:p.A331G	1q24.2	C3N-00511	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.727	D	D	D	0.632	0.733	0.865	0.365	D	D	D	D	D	T	3.983	26.900	0.997	D	D	0.917	11.492	0.921	14.666	1.000	0.707	0.725	0.725	0.568	.	6.170	6.170	7.903	1.026	0.599	1.000	1.000	1.000	777	POU-specific_domain;POU_domain	.	.	.	POU2F1	173	0	305	58	0.159779614325069	TRUE	TRUE
ENSG00000066279.18	.	BCM	GRCh38.p13	chr1	197100872	197100872	+	C	C	T	Missense_Mutation	SNP	ENST00000367409.9	exon18	c.G8379A	p.M2793I	exonic	ENSG00000066279.18	.	nonsynonymous SNV	ENSG00000066279.18:ENST00000367409.9:exon18:c.G8379A:p.M2793I	1q31.3	C3N-00511	8.262e-06	0	0	0	0	1.501e-05	0	0	rs376057172	0.20	T	T	B	B	N	N	N	T	N	0.053	T	T	T	0.011	.	0.061	.	T	T	T	T	T	T	-0.098	0.837	0.351	N	N	-1.534	0.071	-1.533	0.096	0.901	0.706	0.710	0.644	0.613	.	4.490	-3.490	-0.248	-0.369	-0.898	0.000	0.001	0.017	179	.	.	.	ID=COSV54129461;OCCURENCE=1(large_intestine)	ASPM	367	0	947	186	0.164165931156222	TRUE	TRUE
ENSG00000116962.15	.	BCM	GRCh38.p13	chr1	236029604	236029604	+	C	C	T	Missense_Mutation	SNP	ENST00000264187.7	exon7	c.G1684A	p.G562S	exonic	ENSG00000116962.15	.	nonsynonymous SNV	ENSG00000116962.15:ENST00000264187.7:exon7:c.G1684A:p.G562S	1q42.3	C3N-00511	0.0002	0	0	0	0	0	0	0.0006	rs536352898	11.20	T	T	D	D	D	D	M	T	D	0.691	T	T	D	0.240	.	0.612	0.817	T	T	T	T	D	D	3.852	26.100	0.998	D	D	0.672	6.746	0.602	6.247	1.000	0.706	0.725	0.710	0.714	.	5.400	5.400	5.788	1.026	0.599	1.000	0.025	0.334	472	G2_nidogen/fibulin_G2F	.	.	ID=COSV51615314;OCCURENCE=3(haematopoietic_and_lymphoid_tissue)	NID1	285	0	644	154	0.192982456140351	TRUE	TRUE
ENSG00000115705.22	.	BCM	GRCh38.p13	chr2	1496033	1496033	+	G	G	A	Missense_Mutation	SNP	ENST00000329066.9	exon12	c.G2051A	p.R684H	exonic	ENSG00000115705.22	.	nonsynonymous SNV	ENSG00000115705.22:ENST00000329066.9:exon12:c.G2051A:p.R684H	2p25.3	C3N-00511	0.0001	0.0002	0.0004	0	0	0	0	0.0003	rs151064519	0.20	T	T	B	B	N	N	L	T	N	0.120	T	T	T	0.127	.	0.669	0.199	T	T	T	T	T	T	-0.114	0.775	0.879	N	N	-1.310	0.159	-1.500	0.108	1.000	0.487	0.574	0.578	0.613	.	4.520	-6.690	-0.172	-2.469	-1.498	0.000	0.000	0.068	889	.	.	.	.	TPO	275	1	547	142	0.206095791001451	TRUE	NA
ENSG00000173559.14	.	BCM	GRCh38.p13	chr2	191685709	191685709	+	C	C	T	Nonsense_Mutation	SNP	ENST00000425611.8	exon6	c.C556T	p.Q186X	exonic	ENSG00000173559.14	.	stopgain	ENSG00000173559.14:ENST00000425611.8:exon6:c.C556T:p.Q186X	2q32.3	C3N-00511	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.344	.	.	.	.	.	.	.	.	.	D	D	.	.	6.914	36	0.993	D	N	0.834	9.489	0.625	6.554	1.000	0.722	0.702	0.602	0.735	.	5.350	5.350	3.929	1.008	0.599	0.999	0.900	0.082	523	.	.	.	.	NABP1	179	0	319	84	0.208436724565757	TRUE	TRUE
ENSG00000085982.13	.	BCM	GRCh38.p13	chr2	233529467	233529467	+	T	T	C	Missense_Mutation	SNP	ENST00000251722.10	exon12	c.A1514G	p.E505G	exonic	ENSG00000085982.13	.	nonsynonymous SNV	ENSG00000085982.13:ENST00000251722.10:exon12:c.A1514G:p.E505G	2q37.1	C3N-00511	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	N	D	M	T	D	0.648	T	T	T	0.221	0.326	0.301	0.294	T	T	T	T	D	D	4.137	28.100	0.999	D	D	0.551	5.458	0.520	5.344	1.000	0.651	0.634	0.653	0.684	.	5.760	4.590	4.144	1.134	0.661	1.000	1.000	0.999	923	.	.	.	.	USP40	85	0	197	51	0.205645161290323	TRUE	TRUE
ENSG00000163618.18	.	BCM	GRCh38.p13	chr3	62516593	62516593	+	G	G	A	Missense_Mutation	SNP	ENST00000383710.9	exon15	c.C2444T	p.S815L	exonic	ENSG00000163618.18	.	nonsynonymous SNV	ENSG00000163618.18:ENST00000383710.9:exon15:c.C2444T:p.S815L	3p14.2	C3N-00511	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	L	T	D	0.805	T	T	D	0.516	0.422	0.660	0.708	D	D	D	D	D	D	3.597	25.000	0.999	D	D	0.854	9.939	0.884	13.092	1.000	0.638	0.574	0.653	0.542	.	5.950	5.950	10.003	1.176	0.676	1.000	1.000	1.000	605	.	.	.	ID=COSV51901891;OCCURENCE=1(liver)	CADPS	43	0	104	17	0.140495867768595	TRUE	TRUE
ENSG00000227124.11	.	BCM	GRCh38.p13	chr3	75738238	75738238	+	T	T	A	Missense_Mutation	SNP	ENST00000652011.2	exon5	c.A1385T	p.N462I	exonic	ENSG00000227124.11	.	nonsynonymous SNV	ENSG00000227124.11:ENST00000652011.2:exon5:c.A1385T:p.N462I	3p12.3	C3N-00511	.	.	.	.	.	.	.	.	.	0.15	T	T	.	.	.	N	.	T	N	0.142	T	T	T	0.044	.	0.014	.	T	.	T	T	T	T	0.338	4.732	0.561	N	N	-1.079	0.325	-1.267	0.231	1.000	0.566	0.616	0.576	0.264	.	1.750	-0.910	-5.434	0.460	0.551	0.000	0.001	0.001	987	Zinc_finger_C2H2-type	.	.	.	ZNF717	164	1	367	88	0.193406593406593	NA	TRUE
ENSG00000168386.18	.	BCM	GRCh38.p13	chr3	99849839	99849839	+	T	T	A	Nonsense_Mutation	SNP	ENST00000354552.7	exon5	c.A1837T	p.K613X	exonic	ENSG00000168386.18	.	stopgain	ENSG00000168386.18:ENST00000354552.7:exon5:c.A1837T:p.K613X	3q12.1	C3N-00511	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.925	.	.	.	.	.	.	.	.	.	D	D	.	.	7.225	37	0.996	D	N	0.876	10.457	0.764	9.147	1.000	0.707	0.588	0.547	0.714	.	5.790	5.790	6.083	1.138	0.660	1.000	0.995	0.995	445	.	.	.	.	FILIP1L	62	0	170	28	0.141414141414141	TRUE	TRUE
ENSG00000114573.10	.	BCM	GRCh38.p13	chr3	113795934	113795934	+	G	G	A	Missense_Mutation	SNP	ENST00000273398.8	exon11	c.G1285A	p.V429I	exonic	ENSG00000114573.10	.	nonsynonymous SNV	ENSG00000114573.10:ENST00000273398.8:exon11:c.G1285A:p.V429I	3q13.31	C3N-00511	8.247e-06	0	0	0	0	0	0	6.059e-05	rs759887224	15.20	D	T	D	D	D	D	M	T	N	0.492	D	D	D	0.574	.	0.772	1.229	D	D	T	T	D	D	3.908	26.400	0.999	D	D	0.873	10.368	0.850	11.761	1.000	0.745	0.732	0.744	0.584	.	5.560	5.560	9.298	1.176	0.676	1.000	0.997	0.954	300	ATPase,_F1/V1/A1_complex,_alpha/beta_subunit,_nucleotide-binding_domain	.	.	ID=COSV56363383;OCCURENCE=3(large_intestine)	ATP6V1A	128	0	204	45	0.180722891566265	TRUE	TRUE
ENSG00000114127.10	.	BCM	GRCh38.p13	chr3	142311584	142311584	+	G	G	-	Frame_Shift_Del	NA	ENST00000264951.8	exon42	c.5048delC	p.T1683Nfs*29	exonic	ENSG00000114127.10	.	frameshift deletion	ENSG00000114127.10:ENST00000264951.8:exon42:c.5048delC:p.T1683Nfs*29	3q23	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	XRN1	135	0	213	60	0.21978021978022	TRUE	TRUE
ENSG00000174004.6	.	BCM	GRCh38.p13	chr3	196659767	196659767	+	G	G	A	Missense_Mutation	SNP	ENST00000328557.5	exon3	c.G124A	p.D42N	exonic	ENSG00000174004.6	.	nonsynonymous SNV	ENSG00000174004.6:ENST00000328557.5:exon3:c.G124A:p.D42N	3q29	C3N-00511	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	N	.	T	N	0.193	T	T	T	0.093	0.433	0.408	0.379	T	T	T	T	D	T	2.250	21.200	0.954	D	N	-0.236	1.777	-0.107	2.028	1.000	0.672	0.702	0.659	0.684	.	6.060	4.280	2.040	1.176	0.674	0.985	0.831	0.860	500	.	.	.	.	NRROS	45	0	105	11	0.0948275862068965	TRUE	TRUE
ENSG00000248713.1	.	BCM	GRCh38.p13	chr4	99654585	99654585	+	C	C	T	Missense_Mutation	SNP	ENST00000511828.1	exon1	c.G64A	p.D22N	exonic	ENSG00000248713.1	.	nonsynonymous SNV	ENSG00000248713.1:ENST00000511828.1:exon1:c.G64A:p.D22N	4q23	C3N-00511	0.0002	0	0.0053	0	0	0	0	0.0001	rs753181667	0.14	T	T	.	.	.	.	.	T	N	0.094	T	T	T	0.047	0.225	0.102	.	.	T	T	T	T	T	1.839	18.020	0.908	N	N	-0.627	0.940	-0.645	0.979	1.000	0.487	0.574	0.574	0.564	.	4.900	-1.700	0.696	-0.213	-0.176	1.000	0.946	0.961	927	.	.	.	.	C4orf54	93	1	236	55	0.189003436426117	TRUE	NA
ENSG00000171444.18	.	BCM	GRCh38.p13	chr5	113143357	113143357	+	C	C	T	Missense_Mutation	SNP	ENST00000302475.8	exon3	c.G175A	p.E59K	exonic	ENSG00000171444.18	.	nonsynonymous SNV	ENSG00000171444.18:ENST00000302475.8:exon3:c.G175A:p.E59K	5q22.2	C3N-00511	0.0001	0.0013	8.651e-05	0	0.0002	3.001e-05	0	0	rs202120785	14.20	D	D	D	D	D	D	L	T	N	0.901	D	D	D	0.289	.	0.870	0.453	D	T	T	D	T	D	3.493	24.700	0.999	D	D	0.681	6.865	0.714	8.031	1.000	0.706	0.563	0.710	0.613	.	5.960	5.960	6.002	1.026	0.599	1.000	0.987	0.865	914	.	.	.	ID=COSV56727288;OCCURENCE=1(urinary_tract)	MCC	209	0	299	82	0.215223097112861	TRUE	TRUE
ENSG00000120738.8	.	BCM	GRCh38.p13	chr5	138466903	138466903	+	G	G	A	Missense_Mutation	SNP	ENST00000239938.5	exon2	c.G454A	p.E152K	exonic	ENSG00000120738.8	.	nonsynonymous SNV	ENSG00000120738.8:ENST00000239938.5:exon2:c.G454A:p.E152K	5q31.2	C3N-00511	8.238e-06	0	8.637e-05	0	0	0	0	0	rs767122422	14.20	D	D	D	D	D	D	M	T	N	0.861	T	T	D	0.416	0.296	0.738	0.942	T	T	D	D	D	D	4.580	32	0.999	D	D	0.790	8.588	0.760	9.032	1.000	0.726	0.594	0.594	0.555	.	4.890	4.890	10.003	1.176	0.676	1.000	0.997	0.990	370	Early_growth_response_protein	.	.	.	EGR1	164	1	397	93	0.189795918367347	TRUE	NA
ENSG00000253731.3	.	BCM	GRCh38.p13	chr5	141376310	141376310	+	G	G	A	Missense_Mutation	SNP	ENST00000517434.3	exon1	c.G2227A	p.V743M	exonic	ENSG00000253731.3	.	nonsynonymous SNV	ENSG00000253731.3:ENST00000517434.3:exon1:c.G2227A:p.V743M	5q31.3	C3N-00511	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	D	L	T	N	0.068	T	T	T	0.108	0.469	0.452	0.324	.	T	T	T	T	T	0.823	9.623	0.959	N	N	-0.861	0.570	-0.924	0.588	0.077	0.701	0.588	0.717	0.616	.	5.150	-0.377	0.359	-0.486	-0.733	0.010	0.012	0.018	651	Cadherin,_cytoplasmic_C-terminal_domain	.	.	ID=COSV53899875;OCCURENCE=2(large_intestine),1(pancreas)	PCDHGA6	402	0	868	191	0.180358829084042	NA	TRUE
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	170042077	170042077	+	G	G	A	Missense_Mutation	SNP	ENST00000520908.7	exon38	c.G3821A	p.R1274Q	exonic	ENSG00000134516.18	.	nonsynonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon38:c.G3821A:p.R1274Q	5q35.1	C3N-00511	.	.	.	.	.	.	.	.	rs145262338	8.20	D	T	D	P	D	D	L	T	N	0.433	T	T	T	0.285	.	0.772	0.692	T	T	T	T	D	D	3.617	25.100	0.998	D	D	0.466	4.781	0.513	5.276	1.000	0.672	0.702	0.616	0.542	.	5.180	5.180	8.146	1.176	0.676	1.000	0.999	0.830	964	DHR-2_domain;Dedicator_of_cytokinesis,_C-terminal	.	.	ID=COSV99911970;OCCURENCE=1(large_intestine)	DOCK2	167	1	385	97	0.201244813278008	TRUE	NA
ENSG00000154678.18	.	BCM	GRCh38.p13	chr7	31879058	31879058	+	G	G	C	Missense_Mutation	SNP	ENST00000396191.6	exon4	c.C363G	p.S121R	exonic	ENSG00000154678.18	.	nonsynonymous SNV	ENSG00000154678.18:ENST00000396191.6:exon4:c.C363G:p.S121R	7p14.3	C3N-00511	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	N	L	T	D	0.495	T	T	D	0.322	0.434	0.277	0.713	T	T	T	T	D	D	0.529	6.805	0.955	N	N	-1.491	0.084	-1.618	0.070	1.000	0.554	0.547	0.602	0.568	.	5.870	-11.200	-4.697	-0.735	-0.668	0.000	0.909	0.964	865	3'5'-cyclic_nucleotide_phosphodiesterase_N-terminal	.	.	.	PDE1C	140	0	324	83	0.203931203931204	TRUE	TRUE
ENSG00000005469.12	.	BCM	GRCh38.p13	chr7	87392622	87392622	+	G	G	C	Missense_Mutation	SNP	ENST00000331536.8	exon15	c.G1482C	p.M494I	exonic	ENSG00000005469.12	.	nonsynonymous SNV	ENSG00000005469.12:ENST00000331536.8:exon15:c.G1482C:p.M494I	7q21.12	C3N-00511	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.405	D	D	D	0.739	0.639	0.672	0.211	T	D	D	D	D	D	3.912	26.400	0.997	D	D	0.771	8.246	0.771	9.322	1.000	0.651	0.709	0.659	0.655	.	5.930	5.930	5.933	1.176	0.676	1.000	1.000	1.000	488	Choline/carnitine_acyltransferase_domain	.	.	.	CROT	81	0	260	44	0.144736842105263	TRUE	TRUE
ENSG00000146966.13	.	BCM	GRCh38.p13	chr7	140601650	140601650	+	C	C	T	Missense_Mutation	SNP	ENST00000496613.6	exon3	c.G748A	p.V250M	exonic	ENSG00000146966.13	.	nonsynonymous SNV	ENSG00000146966.13:ENST00000496613.6:exon3:c.G748A:p.V250M	7q34	C3N-00511	8.39e-06	0	0	0.0001	0	0	0	0	rs766779073	2.20	D	T	P	B	U	N	L	T	N	0.108	T	T	T	0.056	0.132	0.103	0.213	T	T	T	T	T	T	0.461	6.089	0.936	D	N	-0.750	0.731	-0.852	0.686	0.999	0.615	0.563	0.659	0.542	.	3.790	0.966	2.391	-0.238	-0.182	0.284	0.000	0.003	664	.	.	.	ID=COSV52050018;OCCURENCE=1(large_intestine),1(lung)	DENND2A	69	0	150	31	0.171270718232044	TRUE	TRUE
ENSG00000132549.18	.	BCM	GRCh38.p13	chr8	99275083	99275083	+	G	G	C	Missense_Mutation	SNP	ENST00000358544.6	exon19	c.G2653C	p.D885H	exonic	ENSG00000132549.18	.	nonsynonymous SNV	ENSG00000132549.18:ENST00000358544.6:exon19:c.G2653C:p.D885H	8q22.2	C3N-00511	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	N	D	L	T	N	0.556	T	T	D	0.252	0.266	0.816	0.188	T	T	T	T	D	D	3.321	24.200	0.994	D	D	0.418	4.454	0.435	4.618	1.000	0.651	0.709	0.602	0.655	.	5.580	5.580	8.955	1.176	0.618	1.000	0.896	0.262	844	.	.	.	ID=COSV62160790;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	VPS13B	122	0	239	44	0.15547703180212	TRUE	TRUE
ENSG00000079332.15	.	BCM	GRCh38.p13	chr10	70161066	70161066	+	G	G	A	Missense_Mutation	SNP	ENST00000373241.9	exon4	c.C182T	p.S61L	exonic	ENSG00000079332.15	.	nonsynonymous SNV	ENSG00000079332.15:ENST00000373241.9:exon4:c.C182T:p.S61L	10q22.1	C3N-00511	.	.	.	.	.	.	.	.	.	14.20	D	T	D	P	D	D	M	T	D	0.859	T	T	D	0.603	0.521	0.859	1.473	D	T	D	D	D	D	4.682	32	0.999	D	D	0.837	9.551	0.832	11.152	1.000	0.719	0.723	0.702	0.714	.	5.280	5.280	9.883	1.176	0.676	1.000	1.000	0.998	308	Small_GTP-binding_protein_domain	.	.	ID=COSV64698139;OCCURENCE=1(lung)	SAR1A	112	0	181	43	0.191964285714286	TRUE	TRUE
ENSG00000120051.15	.	BCM	GRCh38.p13	chr10	104400879	104400879	+	G	G	A	Missense_Mutation	SNP	ENST00000369704.8	exon13	c.G2015A	p.S672N	exonic	ENSG00000120051.15	.	nonsynonymous SNV	ENSG00000120051.15:ENST00000369704.8:exon13:c.G2015A:p.S672N	10q25.1	C3N-00511	.	.	.	.	.	.	.	.	.	3.19	D	T	B	B	D	N	.	T	N	0.261	T	T	T	0.063	0.394	0.138	0.039	T	T	T	T	T	T	1.484	15.640	0.989	D	N	-0.283	1.657	-0.072	2.128	0.005	0.615	0.610	0.659	0.564	.	5.870	4.960	1.635	1.176	0.676	0.952	0.994	0.870	167	.	.	.	.	CFAP58	100	0	232	63	0.213559322033898	TRUE	NA
ENSG00000154478.4	.	BCM	GRCh38.p13	chr10	123666778	123666778	+	C	C	T	Missense_Mutation	SNP	ENST00000284674.2	exon1	c.C371T	p.A124V	exonic	ENSG00000154478.4	.	nonsynonymous SNV	ENSG00000154478.4:ENST00000284674.2:exon1:c.C371T:p.A124V	10q26.13	C3N-00511	4.835e-05	0	0	0	0	8.801e-05	0	0	rs775340633	4.20	T	T	B	B	D	D	N	T	N	0.207	T	T	T	0.059	.	0.353	1.032	T	T	T	T	T	D	2.313	21.600	0.996	D	N	-0.148	2.028	0.013	2.403	1.000	0.516	0.610	0.504	0.563	.	4.110	4.110	3.189	1.022	0.596	1.000	0.996	0.992	779	GPCR,_rhodopsin-like,_7TM	.	.	.	GPR26	217	0	530	135	0.203007518796992	TRUE	NA
ENSG00000121898.13	.	BCM	GRCh38.p13	chr10	123746805	123746805	+	G	G	A	Missense_Mutation	SNP	ENST00000241305.4	exon14	c.C2230T	p.R744W	exonic	ENSG00000121898.13	.	nonsynonymous SNV	ENSG00000121898.13:ENST00000241305.4:exon14:c.C2230T:p.R744W	10q26.13	C3N-00511	3.298e-05	0	8.637e-05	0.0002	0	0	0	6.056e-05	rs762600262	14.20	D	D	D	D	N	D	M	D	N	0.480	D	D	D	0.660	.	0.991	0.198	T	T	D	D	T	T	3.579	25.000	0.998	D	D	0.444	4.628	0.389	4.279	0.983	0.653	0.563	0.676	0.564	.	4.980	4.040	2.491	-0.557	-0.691	1.000	0.849	0.951	883	.	.	.	ID=COSV53860503;OCCURENCE=2(stomach)	CPXM2	199	0	407	50	0.109409190371991	TRUE	TRUE
ENSG00000182022.18	.	BCM	GRCh38.p13	chr10	124044714	124044714	+	C	C	T	Missense_Mutation	SNP	ENST00000435907.6	exon3	c.G752A	p.R251H	exonic	ENSG00000182022.18	.	nonsynonymous SNV	ENSG00000182022.18:ENST00000435907.6:exon3:c.G752A:p.R251H	10q26.13	C3N-00511	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.981	T	T	D	0.492	0.568	0.752	1.101	T	D	D	D	D	D	4.262	29.200	1.000	D	D	0.838	9.576	0.828	11.015	1.000	0.563	0.588	0.616	0.636	.	5.650	5.650	7.581	1.026	0.599	1.000	0.999	0.970	844	.	.	.	.	CHST15	108	0	361	75	0.172018348623853	TRUE	NA
ENSG00000006118.14	.	BCM	GRCh38.p13	chr11	60936464	60936464	+	C	C	T	Missense_Mutation	SNP	ENST00000453848.6	exon11	c.C2629T	p.R877C	exonic	ENSG00000006118.14	.	nonsynonymous SNV	ENSG00000006118.14:ENST00000453848.6:exon11:c.C2629T:p.R877C	11q12.2	C3N-00511	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	N	D	M	T	D	0.540	T	T	D	0.148	0.465	0.377	1.103	T	T	T	T	D	D	4.147	28.200	0.999	D	D	0.621	6.139	0.613	6.392	1.000	0.706	0.702	0.644	0.613	.	5.040	5.040	3.748	1.026	0.599	0.999	1.000	0.989	595	Transmembrane_protein_TMEM132,_C-terminal	.	.	ID=COSV50019253;OCCURENCE=2(stomach)	TMEM132A	218	0	445	81	0.153992395437262	TRUE	TRUE
ENSG00000149418.11	.	BCM	GRCh38.p13	chr11	130196371	130196371	+	C	C	G	Missense_Mutation	SNP	ENST00000278742.6	exon10	c.C1146G	p.F382L	exonic	ENSG00000149418.11	.	nonsynonymous SNV	ENSG00000149418.11:ENST00000278742.6:exon10:c.C1146G:p.F382L	11q24.3	C3N-00511	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	N	D	M	T	D	0.879	T	T	D	0.506	0.869	0.556	1.253	T	T	D	D	D	T	3.346	24.200	0.997	D	D	0.421	4.478	0.279	3.600	0.287	0.696	0.634	0.723	0.613	.	4.620	3.710	3.409	0.130	-0.187	1.000	0.282	0.776	788	CUB_domain	.	.	.	ST14	308	0	690	295	0.299492385786802	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-00511	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	235	0	370	117	0.240246406570842	TRUE	TRUE
ENSG00000139629.16	.	BCM	GRCh38.p13	chr12	51377228	51377228	+	C	C	G	Missense_Mutation	SNP	ENST00000356317.8	exon4	c.G631C	p.E211Q	exonic	ENSG00000139629.16	.	nonsynonymous SNV	ENSG00000139629.16:ENST00000356317.8:exon4:c.G631C:p.E211Q	12q13.13	C3N-00511	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	H	T	N	0.957	D	D	D	0.738	0.776	0.945	0.732	T	T	D	D	D	D	3.892	26.300	0.998	D	D	0.882	10.586	0.772	9.344	1.000	0.707	0.725	0.609	0.714	.	4.540	4.540	7.847	1.026	0.599	1.000	1.000	0.992	236	Glycosyltransferase_2-like	.	.	.	GALNT6	180	0	470	111	0.19104991394148	TRUE	TRUE
ENSG00000123338.13	.	BCM	GRCh38.p13	chr12	54518699	54518699	+	G	G	A	Missense_Mutation	SNP	ENST00000293373.11	exon14	c.G1387A	p.V463I	exonic	ENSG00000123338.13	.	nonsynonymous SNV	ENSG00000123338.13:ENST00000293373.11:exon14:c.G1387A:p.V463I	12q13.2	C3N-00511	3.295e-05	0.0004	0	0	0	0	0	0	rs370847426	7.20	T	T	D	D	D	D	L	T	N	0.708	T	T	T	0.254	.	0.262	0.998	T	T	T	T	T	D	3.340	24.200	0.999	D	D	0.818	9.140	0.823	10.855	1.000	0.707	0.725	0.547	0.530	.	5.770	5.770	9.953	1.176	0.676	1.000	0.951	0.932	732	.	.	.	.	NCKAP1L	270	0	434	101	0.188785046728972	TRUE	NA
ENSG00000157423.18	.	BCM	GRCh38.p13	chr16	70964783	70964783	+	C	C	A	Missense_Mutation	SNP	ENST00000393567.7	exon37	c.G5733T	p.K1911N	exonic	ENSG00000157423.18	.	nonsynonymous SNV	ENSG00000157423.18:ENST00000393567.7:exon37:c.G5733T:p.K1911N	16q22.2	C3N-00511	.	.	.	.	.	.	.	.	.	3.16	D	.	.	.	U	N	L	T	D	0.069	T	T	T	0.033	0.191	0.296	.	T	T	T	T	D	.	0.797	9.358	0.988	N	N	-0.808	0.644	-0.855	0.681	1.000	0.497	0.563	0.550	0.542	.	4.930	-0.101	-0.090	0.138	0.599	0.000	0.963	0.916	604	.	.	.	.	HYDIN	173	0	276	22	0.0738255033557047	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675088	7675088	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G524A	p.R175H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G524A:p.R175H	17p13.1	C3N-00511	8.243e-06	0	0	0	0	1.499e-05	0	0	rs28934578	19.20	D	D	D	D	D	A	M	D	D	0.938	D	D	D	0.922	0.986	0.997	1.101	T	D	D	D	D	D	2.987	23.400	0.999	D	D	0.740	7.720	0.711	7.954	1.000	0.722	0.698	0.698	0.735	.	5.410	5.410	6.163	1.026	0.599	1.000	0.996	0.919	434	p53,_DNA-binding_domain	.	.	ID=COSV52661038;OCCURENCE=13(salivary_gland),172(breast),8(penis),1(peritoneum),14(liver),118(oesophagus),6(adrenal_gland),1(meninges),5(cervix),604(large_intestine),116(central_nervous_system),23(biliary_tract),94(ovary),9(vulva),2(pleura),5(bone),6(NS),124(stomach),74(haematopoietic_and_lymphoid_tissue),14(soft_tissue),21(kidney),38(urinary_tract),75(pancreas),10(skin),28(prostate),47(lung),14(thyroid),109(upper_aerodigestive_tract),1(testis),1(eye),3(small_intestine),31(endometrium)	TP53	354	0	476	160	0.251572327044025	TRUE	TRUE
ENSG00000133026.13	.	BCM	GRCh38.p13	chr17	8521120	8521120	+	C	C	T	Missense_Mutation	SNP	ENST00000269243.8	exon16	c.G2030A	p.R677H	exonic	ENSG00000133026.13	.	nonsynonymous SNV	ENSG00000133026.13:ENST00000269243.8:exon16:c.G2030A:p.R677H	17p13.1	C3N-00511	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.960	D	D	D	0.904	0.961	0.987	2.352	D	D	D	D	D	D	4.234	29.000	1.000	D	D	1.156	20.411	1.056	22.784	1.000	0.707	0.659	0.725	0.711	.	5.930	5.930	7.905	1.026	0.599	1.000	1.000	0.993	531	Myosin_head,_motor_domain	.	.	.	MYH10	164	0	271	15	0.0524475524475524	TRUE	TRUE
ENSG00000168961.17	.	BCM	GRCh38.p13	chr17	27646559	27646559	+	C	C	T	Missense_Mutation	SNP	ENST00000395473.7	exon8	c.C640T	p.P214S	exonic	ENSG00000168961.17	.	nonsynonymous SNV	ENSG00000168961.17:ENST00000395473.7:exon8:c.C640T:p.P214S	17q11.2	C3N-00511	.	.	.	.	.	.	.	.	.	2.20	D	T	B	B	N	N	L	T	D	0.273	T	T	T	0.023	0.347	0.314	0.423	T	T	T	T	T	T	0.948	10.970	0.815	N	N	-0.822	0.624	-0.882	0.645	0.648	0.732	0.702	0.602	0.728	.	4.190	2.190	0.520	-0.303	-0.258	0.003	0.004	0.006	251	.	.	.	.	LGALS9	271	0	430	138	0.242957746478873	NA	TRUE
ENSG00000129353.15	.	BCM	GRCh38.p13	chr19	10631683	10631683	+	A	A	G	Missense_Mutation	SNP	ENST00000335757.10	exon8	c.A560G	p.N187S	exonic	ENSG00000129353.15	.	nonsynonymous SNV	ENSG00000129353.15:ENST00000335757.10:exon8:c.A560G:p.N187S	19p13.2	C3N-00511	.	.	.	.	.	.	.	.	.	8.20	T	D	B	B	D	D	M	T	N	0.739	T	T	T	0.122	0.473	0.453	0.813	T	T	T	T	D	D	2.526	22.500	0.986	D	D	0.036	2.642	0.171	3.044	1.000	0.722	0.725	0.702	0.735	.	4.730	4.730	8.348	1.311	0.754	1.000	0.997	0.834	814	.	.	.	.	SLC44A2	321	0	731	162	0.181410974244121	TRUE	TRUE
ENSG00000180884.10	.	BCM	GRCh38.p13	chr19	34958105	34958105	+	G	G	C	Missense_Mutation	SNP	ENST00000404801.2	exon4	c.C1750G	p.H584D	exonic	ENSG00000180884.10	.	nonsynonymous SNV	ENSG00000180884.10:ENST00000404801.2:exon4:c.C1750G:p.H584D	19q13.11	C3N-00511	.	.	.	.	.	.	.	.	.	12.19	D	D	D	P	.	D	N	D	D	0.711	D	D	D	0.428	0.775	0.803	0.773	T	T	D	T	D	T	3.363	24.300	0.990	N	D	0.052	2.700	-0.028	2.264	1.000	0.707	0.654	0.725	0.711	.	2.640	2.640	8.396	0.909	0.676	1.000	0.981	0.821	307	Zinc_finger_C2H2-type	.	.	.	ZNF792	181	0	354	80	0.184331797235023	TRUE	TRUE
ENSG00000074219.14	.	BCM	GRCh38.p13	chr19	49357267	49357267	+	G	G	C	Missense_Mutation	SNP	ENST00000311227.6	exon4	c.C345G	p.I115M	exonic	ENSG00000074219.14	.	nonsynonymous SNV	ENSG00000074219.14:ENST00000311227.6:exon4:c.C345G:p.I115M	19q13.33	C3N-00511	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	D	D	L	T	N	0.320	T	T	T	0.179	0.417	0.570	0.765	T	D	T	T	D	D	2.155	20.500	0.992	D	N	-0.070	2.270	-0.187	1.817	0.954	0.722	0.578	0.702	0.735	.	5.410	-3.990	-0.102	-0.126	-0.126	0.750	0.998	0.997	774	TEA/ATTS_domain	.	.	.	TEAD2	203	0	488	109	0.182579564489112	TRUE	TRUE
ENSG00000160318.6	.	BCM	GRCh38.p13	chr19	51367161	51367161	+	C	C	A	Missense_Mutation	SNP	ENST00000291715.5	exon4	c.G485T	p.G162V	exonic	ENSG00000160318.6	.	nonsynonymous SNV	ENSG00000160318.6:ENST00000291715.5:exon4:c.G485T:p.G162V	19q13.41	C3N-00511	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	N	N	N	D	N	0.398	D	D	D	0.476	0.481	0.813	1.126	T	T	D	D	D	T	2.843	23.100	0.993	N	N	-0.156	2.005	-0.325	1.513	1.000	0.442	0.484	0.522	0.492	.	4.640	1.350	-0.588	1.010	0.529	0.000	0.978	0.993	982	.	.	.	.	CLDND2	250	0	515	107	0.172025723472669	TRUE	TRUE
ENSG00000130726.12	.	BCM	GRCh38.p13	chr19	58544912	58544912	+	C	C	G	Missense_Mutation	SNP	ENST00000253024.10	exon1	c.C155G	p.A52G	exonic	ENSG00000130726.12	.	nonsynonymous SNV	ENSG00000130726.12:ENST00000253024.10:exon1:c.C155G:p.A52G	19q13.43	C3N-00511	.	.	.	.	.	.	.	.	.	3.20	D	T	B	B	U	N	N	T	N	0.112	T	T	D	0.122	0.188	0.311	0.634	D	T	T	T	T	T	1.853	18.130	0.746	N	N	-1.001	0.403	-1.106	0.370	1.000	0.733	0.522	0.601	0.373	.	1.940	-0.418	0.157	0.892	-0.501	0.000	0.970	0.033	958	.	.	.	.	TRIM28	69	0	185	61	0.247967479674797	TRUE	TRUE
ENSG00000124151.19	.	BCM	GRCh38.p13	chr20	47627026	47627026	+	G	G	T	Missense_Mutation	SNP	ENST00000371998.8	exon6	c.G382T	p.V128L	exonic	ENSG00000124151.19	.	nonsynonymous SNV	ENSG00000124151.19:ENST00000371998.8:exon6:c.G382T:p.V128L	20q13.12	C3N-00511	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	L	T	D	0.751	T	T	D	0.509	.	0.770	0.543	D	D	D	D	D	D	3.976	26.800	0.995	D	D	0.461	4.749	0.439	4.651	1.000	0.707	0.725	0.659	0.714	.	6.170	5.220	10.003	1.176	0.676	1.000	1.000	1.000	126	PAS_fold;PAS_domain	.	.	.	NCOA3	36	0	96	25	0.206611570247934	TRUE	TRUE
ENSG00000171587.15	.	BCM	GRCh38.p13	chr21	40369134	40369134	+	G	G	A	Missense_Mutation	SNP	ENST00000400454.6	exon4	c.C620T	p.T207M	exonic	ENSG00000171587.15	.	nonsynonymous SNV	ENSG00000171587.15:ENST00000400454.6:exon4:c.C620T:p.T207M	21q22.2	C3N-00511	2.492e-05	0.0003	0	0	0	0	0	0	rs747625181	14.20	D	D	D	D	D	D	M	T	D	0.768	T	T	D	0.335	0.224	0.617	1.502	D	T	T	T	D	D	3.610	25.100	0.999	D	D	0.804	8.858	0.738	8.530	1.000	0.487	0.574	0.574	0.564	.	6.070	5.190	8.026	0.190	0.676	1.000	0.290	0.875	970	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV68634704;OCCURENCE=1(stomach),1(skin)	DSCAM	87	0	213	52	0.19622641509434	TRUE	TRUE
ENSG00000099904.15	.	BCM	GRCh38.p13	chr22	20145258	20145258	+	G	G	A	Missense_Mutation	SNP	ENST00000334554.11	exon11	c.G2156A	p.S719N	exonic	ENSG00000099904.15	.	nonsynonymous SNV	ENSG00000099904.15:ENST00000334554.11:exon11:c.G2156A:p.S719N	22q11.21	C3N-00511	9.046e-06	0	0	0	0	0	0	9.817e-05	rs760087056	5.19	D	T	P	B	N	D	L	T	N	0.138	T	T	D	0.226	0.137	0.198	.	.	T	T	T	T	T	2.369	21.900	0.997	D	D	0.352	4.060	0.436	4.622	1.000	0.672	0.644	0.723	0.711	.	5.060	5.060	5.183	1.172	0.672	1.000	1.000	0.989	783	.	.	.	.	ZDHHC8	44	0	70	4	0.0540540540540541	TRUE	NA
ENSG00000182798.10	.	BCM	GRCh38.p13	chrX	16170900	16170900	+	G	G	A	Missense_Mutation	SNP	ENST00000400004.6	exon2	c.G518A	p.R173H	exonic	ENSG00000182798.10	.	nonsynonymous SNV	ENSG00000182798.10:ENST00000400004.6:exon2:c.G518A:p.R173H	Xp22.2	C3N-00511	.	.	.	.	.	.	.	.	.	0.17	T	T	.	.	N	N	L	T	N	0.032	T	T	T	0.018	0.283	0.085	0.259	T	T	T	T	T	T	0.246	3.657	0.924	N	.	.	.	.	.	0.958	.	.	.	.	.	2.560	-5.070	-0.364	-2.235	-0.712	0.000	0.000	0.000	416	MAGE_homology_domain	.	.	ID=COSV61556834;OCCURENCE=1(stomach)	MAGEB17	134	0	268	49	0.154574132492114	TRUE	TRUE
ENSG00000154447.15	.	BCM	GRCh38.p13	chr4	169116268	169116268	+	C	C	-	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000154447.15	ENST00000284637.14:exon10:c.2139+1G>-	.	.	4q32.3	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SH3RF1	36	0	92	8	0.08	TRUE	TRUE
ENSG00000149305.7	.	BCM	GRCh38.p13	chr11	113931429	113931429	+	G	G	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000149305.7	ENST00000260191.7:exon3:c.258+1G>C	.	.	11q23.2	C3N-00511	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.161	33	0.991	D	.	1.088	17.014	0.916	14.447	1.000	0.054	0.063	0.060	0.057	0.980	5.650	5.650	7.965	1.176	0.676	1.000	0.957	0.764	874	.	.	.	.	HTR3B	47	0	127	17	0.118055555555556	TRUE	TRUE
ENSG00000140598.15	.	BCM	GRCh38.p13	chr15	82229033	82229033	+	C	C	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000140598.15	ENST00000268206.12:exon9:c.932+1G>C	.	.	15q25.2	C3N-00511	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.233	29.000	0.995	D	.	0.997	13.820	0.798	10.055	1.000	0.164	0.156	0.121	0.243	0.972	3.950	3.950	6.404	1.026	0.548	1.000	0.998	0.945	890	.	.	.	.	EFL1	20	0	80	15	0.157894736842105	NA	TRUE
ENSG00000176092.15	.	BCM	GRCh38.p13	chr1	26337627	26337627	+	C	C	A	Silent	SNP	ENST00000308182.9	exon9	c.G3555T	p.V1185V	exonic	ENSG00000176092.15	.	synonymous SNV	ENSG00000176092.15:ENST00000308182.9:exon9:c.G3555T:p.V1185V	1p36.11	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CRYBG2	142	1	381	58	0.132118451025057	TRUE	TRUE
ENSG00000198198.17	.	BCM	GRCh38.p13	chr1	43441588	43441588	+	T	T	C	Silent	SNP	ENST00000634258.3	exon54	c.T7596C	p.F2532F	exonic	ENSG00000198198.17	.	synonymous SNV	ENSG00000198198.17:ENST00000634258.3:exon54:c.T7596C:p.F2532F	1p34.2	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SZT2	131	0	240	45	0.157894736842105	TRUE	TRUE
ENSG00000153823.18	.	BCM	GRCh38.p13	chr2	229025845	229025845	+	G	G	A	Silent	SNP	ENST00000354069.6	exon3	c.C540T	p.F180F	exonic	ENSG00000153823.18	.	synonymous SNV	ENSG00000153823.18:ENST00000354069.6:exon3:c.C540T:p.F180F	2q36.3	C3N-00511	8.237e-06	0	0	0	0	0	0	6.056e-05	rs749402709	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62472386;OCCURENCE=2(large_intestine),4(pancreas),3(skin)	PID1	394	0	754	183	0.195304162219851	TRUE	TRUE
ENSG00000213413.2	.	BCM	GRCh38.p13	chr7	100221044	100221044	+	G	G	A	Silent	SNP	ENST00000317271.2	exon6	c.G774A	p.A258A	exonic	ENSG00000213413.2	.	synonymous SNV	ENSG00000213413.2:ENST00000317271.2:exon6:c.G774A:p.A258A	7q22.1	C3N-00511	1.664e-05	0	0	0	0	1.508e-05	0	6.26e-05	rs556053924	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52782082;OCCURENCE=1(biliary_tract)	PVRIG	62	0	166	51	0.235023041474654	NA	TRUE
ENSG00000168484.12	.	BCM	GRCh38.p13	chr8	22162672	22162672	+	C	C	T	Silent	SNP	ENST00000318561.7	exon2	c.C141T	p.V47V	exonic	ENSG00000168484.12	.	synonymous SNV	ENSG00000168484.12:ENST00000318561.7:exon2:c.C141T:p.V47V	8p21.3	C3N-00511	8.281e-06	0	0	0	0	1.499e-05	0	0	rs764818190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SFTPC	505	0	1078	258	0.19311377245509	TRUE	NA
ENSG00000107951.14	.	BCM	GRCh38.p13	chr10	30313843	30313843	+	A	A	G	Silent	SNP	ENST00000263063.8	exon9	c.T1515C	p.S505S	exonic	ENSG00000107951.14	.	synonymous SNV	ENSG00000107951.14:ENST00000263063.8:exon9:c.T1515C:p.S505S	10p11.23	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MTPAP	322	0	1770	142	0.0742677824267782	TRUE	TRUE
ENSG00000064309.14	.	BCM	GRCh38.p13	chr11	126005885	126005885	+	A	A	T	Silent	SNP	ENST00000392693.7	exon9	c.T1725A	p.S575S	exonic	ENSG00000064309.14	.	synonymous SNV	ENSG00000064309.14:ENST00000392693.7:exon9:c.T1725A:p.S575S	11q24.2	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDON	284	0	672	167	0.199046483909416	TRUE	TRUE
ENSG00000170486.11	.	BCM	GRCh38.p13	chr12	52587801	52587801	+	G	G	A	Silent	SNP	ENST00000293745.7	exon7	c.C1140T	p.C380C	exonic	ENSG00000170486.11	.	synonymous SNV	ENSG00000170486.11:ENST00000293745.7:exon7:c.C1140T:p.C380C	12q13.13	C3N-00511	1.651e-05	0	8.658e-05	0.0001	0	0	0	0	rs199978375	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53373473;OCCURENCE=1(breast),1(stomach)	KRT72	191	1	429	115	0.211397058823529	TRUE	TRUE
ENSG00000120658.13	.	BCM	GRCh38.p13	chr13	43355953	43355953	+	C	C	T	Silent	SNP	ENST00000261488.10	exon8	c.G789A	p.E263E	exonic	ENSG00000120658.13	.	synonymous SNV	ENSG00000120658.13:ENST00000261488.10:exon8:c.G789A:p.E263E	13q14.11	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54921473;OCCURENCE=1(liver)	ENOX1	109	0	245	63	0.204545454545455	TRUE	TRUE
ENSG00000124467.19	.	BCM	GRCh38.p13	chr19	42763916	42763916	+	G	G	A	Silent	SNP	ENST00000306511.5	exon2	c.C430T	p.L144L	exonic	ENSG00000124467.19	.	synonymous SNV	ENSG00000124467.19:ENST00000306511.5:exon2:c.C430T:p.L144L	19q13.2	C3N-00511	.	.	.	.	.	.	.	.	.	2.16	T	T	B	B	.	D	.	T	D	0.077	T	T	T	0.036	0.642	0.014	.	.	.	T	T	T	T	-0.673	0.050	0.533	N	N	-0.662	0.877	-0.949	0.555	0.002	0.428	0.547	0.547	0.613	.	1.350	0.266	-3.080	-1.225	-4.116	0.000	0.000	0.000	410	.	.	.	ID=COSV60610769;OCCURENCE=1(large_intestine),2(skin),1(lung)	PSG8	110	0	194	66	0.253846153846154	NA	TRUE
ENSG00000063169.10	.	BCM	GRCh38.p13	chr19	47680901	47680901	+	G	G	A	Silent	SNP	ENST00000396720.7	exon6	c.G1731A	p.P577P	exonic	ENSG00000063169.10	.	synonymous SNV	ENSG00000063169.10:ENST00000396720.7:exon6:c.G1731A:p.P577P	19q13.33	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BICRA	54	0	138	37	0.211428571428571	TRUE	NA
ENSG00000197951.9	.	BCM	GRCh38.p13	chr19	56622481	56622481	+	C	C	T	Silent	SNP	ENST00000328070.10	exon3	c.C1194T	p.I398I	exonic	ENSG00000197951.9	.	synonymous SNV	ENSG00000197951.9:ENST00000328070.10:exon3:c.C1194T:p.I398I	19q13.43	C3N-00511	.	.	.	.	.	.	.	.	rs1051755100	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60148032;OCCURENCE=1(skin)	ZNF71	191	0	514	117	0.185419968304279	TRUE	TRUE
ENSG00000101400.6	.	BCM	GRCh38.p13	chr20	33412707	33412707	+	C	C	T	Silent	SNP	ENST00000217381.3	exon4	c.G777A	p.S259S	exonic	ENSG00000101400.6	.	synonymous SNV	ENSG00000101400.6:ENST00000217381.3:exon4:c.G777A:p.S259S	20q11.21	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SNTA1	529	0	1087	280	0.204828090709583	TRUE	NA
ENSG00000004961.15	.	BCM	GRCh38.p13	chrX	11121657	11121657	+	C	C	T	Silent	SNP	ENST00000380762.5	exon7	c.C654T	p.C218C	exonic	ENSG00000004961.15	.	synonymous SNV	ENSG00000004961.15:ENST00000380762.5:exon7:c.C654T:p.C218C	Xp22.2	C3N-00511	6.84e-05	0	0.0002	0.0002	0	4.168e-05	0	9.89e-05	rs775880525	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58239116;OCCURENCE=1(biliary_tract)	HCCS	287	0	488	117	0.193388429752066	TRUE	TRUE
ENSG00000001497.16	.	BCM	GRCh38.p13	chrX	65524096	65524096	+	G	G	A	Silent	SNP	ENST00000374811.7	exon10	c.C1260T	p.L420L	exonic	ENSG00000001497.16	.	synonymous SNV	ENSG00000001497.16:ENST00000374811.7:exon10:c.C1260T:p.L420L	Xq12	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LAS1L	299	0	614	136	0.181333333333333	TRUE	TRUE
ENSG00000127603.29	.	BCM	GRCh38.p13	chr1	39269435	39269435	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000127603.29	.	.	.	1p34.3	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MACF1	283	0	604	141	0.189261744966443	TRUE	NA
ENSG00000050767.17	.	BCM	GRCh38.p13	chr5	178255788	178255788	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000050767.17	.	.	.	5q35.3	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL23A1	17	0	49	3	0.0576923076923077	TRUE	NA
ENSG00000260537.2	.	BCM	GRCh38.p13	chr16	70346901	70346901	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000260537.2	.	.	.	16q22.1	C3N-00511	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC012184.2	49	0	87	38	0.304	TRUE	NA
ENSG00000174175.17	.	BCM	GRCh38.p13	chr1	169613033	169613033	+	G	G	A	Missense_Mutation	SNP	ENST00000263686.11	exon5	c.C671T	p.S224L	exonic	ENSG00000174175.17	.	nonsynonymous SNV	ENSG00000174175.17:ENST00000263686.11:exon5:c.C671T:p.S224L	1q24.2	C3N-03190	6.603e-05	0	8.673e-05	0	0.0003	7.5e-05	0	0	rs767813249	14.17	D	D	.	.	D	D	.	T	D	0.771	D	D	D	0.620	.	0.902	0.341	T	T	D	D	D	D	4.285	29.400	0.999	D	D	1.024	14.691	0.944	15.781	1.000	0.615	0.547	0.574	0.655	.	5.980	5.980	7.013	1.176	0.676	1.000	0.922	0.833	775	Sushi/SCR/CCP_domain	.	.	ID=COSV55253485;OCCURENCE=1(stomach)	SELP	147	0	282	57	0.168141592920354	TRUE	TRUE
ENSG00000179930.6	.	BCM	GRCh38.p13	chr1	182056629	182056629	+	G	G	A	Missense_Mutation	SNP	ENST00000339948.3	exon2	c.C1382T	p.S461L	exonic	ENSG00000179930.6	.	nonsynonymous SNV	ENSG00000179930.6:ENST00000339948.3:exon2:c.C1382T:p.S461L	1q25.3	C3N-03190	.	.	.	.	.	.	.	.	.	8.19	D	D	P	B	.	D	M	T	D	0.101	T	T	T	0.100	0.490	0.169	1.119	D	T	T	T	D	D	2.877	23.200	0.998	N	N	-0.092	2.199	-0.165	1.871	0.211	0.487	0.563	0.616	0.564	.	2.770	1.850	1.323	1.176	0.676	0.014	1.000	0.998	910	Zinc_finger_C2H2-type	.	.	.	ZNF648	444	0	941	88	0.0855199222546161	TRUE	NA
ENSG00000068781.21	.	BCM	GRCh38.p13	chr2	48646534	48646534	+	A	A	C	Missense_Mutation	SNP	ENST00000403751.8	exon6	c.A470C	p.Q157P	exonic	ENSG00000068781.21;ENSG00000242441.8	.	nonsynonymous SNV	ENSG00000242441.8:ENST00000403751.8:exon6:c.A470C:p.Q157P,ENSG00000068781.21:ENST00000394754.5:exon8:c.A2582C:p.Q861P	2p16.3	C3N-03190	8.241e-06	9.625e-05	0	0	0	0	0	0	rs139159145	4.20	T	T	P	B	N	N	M	T	D	0.367	T	T	T	0.195	.	0.365	0.007	T	T	T	T	D	T	2.144	20.400	0.968	D	N	-0.077	2.248	-0.028	2.264	0.000	0.554	0.588	0.574	0.564	.	5.820	3.240	1.529	1.312	0.691	0.993	0.886	0.389	534	.	.	.	.	STON1-GTF2A1L	158	0	391	24	0.0578313253012048	TRUE	NA
ENSG00000188738.15	.	BCM	GRCh38.p13	chr2	185804071	185804071	+	C	C	G	Missense_Mutation	SNP	ENST00000424728.6	exon17	c.C14765G	p.A4922G	exonic	ENSG00000188738.15	.	nonsynonymous SNV	ENSG00000188738.15:ENST00000424728.6:exon17:c.C14765G:p.A4922G	2q32.1	C3N-03190	.	.	.	.	.	.	.	.	.	0.16	T	T	.	.	.	N	L	T	N	0.092	T	T	T	0.020	.	0.234	.	T	T	T	T	T	T	0.359	4.961	0.619	N	.	-0.740	0.747	-0.800	0.758	0.000	0.554	0.588	0.574	0.621	.	5.450	2.630	-0.211	-0.268	-0.964	0.000	0.077	0.225	735	Fibrous_sheath-interacting_protein_2,_C-terminal	.	.	.	FSIP2	49	0	131	15	0.102739726027397	TRUE	TRUE
ENSG00000188582.10	.	BCM	GRCh38.p13	chr3	142962715	142962715	+	C	C	T	Missense_Mutation	SNP	ENST00000340634.6	exon1	c.G622A	p.A208T	exonic	ENSG00000188582.10	.	nonsynonymous SNV	ENSG00000188582.10:ENST00000340634.6:exon1:c.G622A:p.A208T	3q23	C3N-03190	.	.	.	.	.	.	.	.	.	0.19	T	T	P	B	N	N	L	T	N	0.069	T	T	T	0.069	0.588	0.103	1.512	T	T	T	T	T	T	1.473	15.570	0.990	N	.	-0.205	1.864	-0.147	1.918	1.000	0.652	0.563	0.641	0.639	.	4.900	4.900	0.304	1.026	0.599	0.000	0.989	0.965	917	.	.	.	ID=COSV61417597;OCCURENCE=1(breast),1(oesophagus),2(large_intestine),1(stomach),1(endometrium)	PAQR9	320	0	725	118	0.139976275207592	TRUE	TRUE
ENSG00000231925.12	.	BCM	GRCh38.p13	chr6	33313312	33313312	+	A	A	G	Missense_Mutation	SNP	ENST00000434618.7	exon3	c.T374C	p.M125T	exonic	ENSG00000231925.12	.	nonsynonymous SNV	ENSG00000231925.12:ENST00000434618.7:exon3:c.T374C:p.M125T	6p21.32	C3N-03190	.	.	.	.	.	.	.	.	.	3.19	T	D	P	B	N	D	.	T	N	0.416	T	T	T	0.112	0.524	0.415	0.404	T	T	T	T	T	T	2.062	19.730	0.893	D	N	0.042	2.666	0.111	2.780	1.000	0.442	0.522	0.522	0.562	.	4.300	4.300	1.890	1.301	0.743	0.986	0.989	0.998	632	.	.	.	.	TAPBP	258	0	555	74	0.117647058823529	TRUE	TRUE
ENSG00000188107.15	.	BCM	GRCh38.p13	chr6	65495077	65495077	+	C	C	T	Missense_Mutation	SNP	ENST00000370621.7	exon4	c.G334A	p.V112I	exonic	ENSG00000188107.15	.	nonsynonymous SNV	ENSG00000188107.15:ENST00000370621.7:exon4:c.G334A:p.V112I	6q12	C3N-03190	0.0086	0.0012	0.0048	0.0005	0.0002	0.0065	0.0110	0.0323	rs112609906	1.18	T	T	B	B	.	N	N	D	N	0.055	T	T	.	0.191	.	0.236	0.010	T	T	T	T	T	T	0.261	3.838	0.482	N	N	-0.778	0.687	-0.610	1.030	0.000	0.487	0.574	0.574	0.564	.	4.700	0.626	1.444	0.203	-0.172	1.000	0.708	0.587	916	.	.	.	ID=COSV60995573;OCCURENCE=1(thyroid)	EYS	180	0	318	69	0.178294573643411	TRUE	NA
ENSG00000049540.17	.	BCM	GRCh38.p13	chr7	74059903	74059903	+	G	G	T	Missense_Mutation	SNP	ENST00000358929.8	exon24	c.G1519T	p.G507C	exonic	ENSG00000049540.17	.	nonsynonymous SNV	ENSG00000049540.17:ENST00000358929.8:exon24:c.G1519T:p.G507C	7q11.23	C3N-03190	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	.	D	L	T	D	0.821	T	T	D	0.285	0.376	0.713	0.195	T	D	D	D	D	T	3.548	24.900	0.973	D	N	0.199	3.300	0.038	2.496	1.000	0.646	0.590	0.645	0.563	.	3.710	2.810	3.546	0.811	0.672	0.892	0.002	0.001	917	.	.	.	.	ELN	669	1	1414	246	0.148192771084337	TRUE	TRUE
ENSG00000181638.20	.	BCM	GRCh38.p13	chr8	143250081	143250081	+	C	C	A	Missense_Mutation	SNP	ENST00000330701.7	exon2	c.C238A	p.P80T	exonic	ENSG00000181638.20;ENSG00000264668.2	.	nonsynonymous SNV	ENSG00000181638.20:ENST00000330701.7:exon2:c.C238A:p.P80T,ENSG00000264668.2:ENST00000522452.2:exon2:c.C238A:p.P80T	8q24.3	C3N-03190	.	.	.	.	.	.	.	.	.	0.12	.	T	.	.	.	N	.	.	.	0.199	T	T	T	0.086	.	0.165	0.110	T	.	T	T	T	T	1.915	18.600	0.863	N	N	-0.321	1.563	-0.420	1.337	0.999	0.651	0.588	0.645	0.684	.	2.820	2.820	2.526	0.074	-0.239	0.017	0.987	0.993	982	.	.	.	.	ZFP41	249	0	673	91	0.119109947643979	TRUE	TRUE
ENSG00000110169.11	.	BCM	GRCh38.p13	chr11	6440523	6440523	+	-	NA	CAT	In_Frame_Ins	INS	ENST00000265983.8	exon3	c.157_158insATG	p.D52_G53insD	exonic	ENSG00000110169.11	.	nonframeshift insertion	ENSG00000110169.11:ENST00000265983.8:exon3:c.157_158insATG:p.D52_G53insD	11p15.4	C3N-03190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HPX	NA	NA	NA	NA	NA	NA	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-03190	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	285	0	684	212	0.236607142857143	TRUE	TRUE
ENSG00000139117.14	.	BCM	GRCh38.p13	chr12	38839939	38839939	+	T	T	C	Missense_Mutation	SNP	ENST00000331366.10	exon5	c.A307G	p.K103E	exonic	ENSG00000139117.14	.	nonsynonymous SNV	ENSG00000139117.14:ENST00000331366.10:exon5:c.A307G:p.K103E	12q12	C3N-03190	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	L	T	N	0.553	T	T	D	0.228	0.441	0.714	0.831	D	T	T	T	D	D	2.824	23.100	0.997	D	D	0.151	3.094	0.237	3.370	0.783	0.706	0.709	0.602	0.613	.	4.380	4.380	5.683	1.138	0.665	1.000	1.000	0.998	819	C2_domain	.	.	.	CPNE8	84	0	235	35	0.12962962962963	TRUE	TRUE
ENSG00000139219.19	.	BCM	GRCh38.p13	chr12	47985811	47985811	+	G	G	A	Nonsense_Mutation	SNP	ENST00000380518.8	exon25	c.C1597T	p.R533X	exonic	ENSG00000139219.19	.	stopgain	ENSG00000139219.19:ENST00000380518.8:exon25:c.C1597T:p.R533X	12q13.11	C3N-03190	.	.	.	.	.	.	.	.	rs1085307608	5.6	.	.	.	.	D	A	.	.	.	0.952	.	.	.	.	.	.	.	.	.	D	D	.	.	8.491	43	0.998	D	N	0.912	11.373	0.790	9.825	1.000	0.615	0.627	0.659	0.564	.	5.480	4.580	8.047	1.176	0.676	1.000	1.000	0.980	612	.	.	.	.	COL2A1	383	0	799	151	0.158947368421053	TRUE	NA
ENSG00000172867.4	.	BCM	GRCh38.p13	chr12	52651890	52651890	+	C	C	T	Missense_Mutation	SNP	ENST00000309680.4	exon1	c.G253A	p.A85T	exonic	ENSG00000172867.4	.	nonsynonymous SNV	ENSG00000172867.4:ENST00000309680.4:exon1:c.G253A:p.A85T	12q13.13	C3N-03190	5.686e-05	0	0	0	0	6.98e-05	0	0.0001	rs747178935	2.19	T	T	B	B	.	N	N	D	N	0.222	T	T	D	0.183	0.372	0.400	0.083	T	T	T	T	T	T	-0.301	0.310	0.774	N	N	-1.516	0.076	-1.551	0.090	0.001	0.497	0.563	0.547	0.542	.	5.270	-3.300	0.065	-0.631	-0.778	0.000	0.002	0.065	761	Keratin_type_II_head	.	.	ID=COSV59011400;OCCURENCE=1(liver)	KRT2	143	0	387	59	0.132286995515695	TRUE	TRUE
ENSG00000139291.14	.	BCM	GRCh38.p13	chr12	71689613	71689613	+	G	G	A	Missense_Mutation	SNP	ENST00000548802.1	exon2	c.G218A	p.R73H	exonic	ENSG00000139291.14;ENSG00000258064.1	.	nonsynonymous SNV	ENSG00000258064.1:ENST00000548802.1:exon2:c.G218A:p.R73H	12q21.1	C3N-03190	4.942e-05	9.612e-05	8.637e-05	0	0	1.498e-05	0	0.0002	rs146789654	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57000898;OCCURENCE=1(large_intestine)	TMEM19	264	1	625	108	0.147339699863574	TRUE	TRUE
ENSG00000187676.8	.	BCM	GRCh38.p13	chr13	31247095	31247095	+	C	C	T	Missense_Mutation	SNP	ENST00000343307.5	exon5	c.C343T	p.P115S	exonic	ENSG00000187676.8	.	nonsynonymous SNV	ENSG00000187676.8:ENST00000343307.5:exon5:c.C343T:p.P115S	13q12.3	C3N-03190	.	.	.	.	.	.	.	.	.	9.20	D	T	P	P	D	D	M	T	D	0.429	T	T	D	0.515	0.652	0.807	0.727	T	T	T	T	D	D	3.388	24.400	0.999	D	N	0.540	5.360	0.518	5.327	0.940	0.638	0.588	0.653	0.655	.	5.610	5.610	3.206	1.026	0.549	0.995	0.054	0.954	900	.	.	.	.	B3GLCT	365	0	724	118	0.140142517814727	TRUE	TRUE
ENSG00000178115.11	.	BCM	GRCh38.p13	chr15	30562202	30562202	+	C	C	T	Missense_Mutation	SNP	ENST00000562783.1	exon18	c.C1685T	p.P562L	exonic	ENSG00000178115.11	.	nonsynonymous SNV	ENSG00000178115.11:ENST00000562783.1:exon18:c.C1685T:p.P562L	15q13.2	C3N-03190	.	.	.	.	.	.	.	.	.	4.10	D	D	.	.	.	.	.	T	D	0.056	.	.	T	.	.	0.248	0.973	.	.	T	T	.	D	2.139	20.400	0.991	N	N	.	.	.	.	0.000	0.554	0.588	0.618	0.621	.	0.861	0.861	0.041	0.661	0.255	0.002	0.006	0.024	976	.	.	.	.	GOLGA8Q	382	0	892	76	0.0785123966942149	NA	TRUE
ENSG00000242866.10	.	BCM	GRCh38.p13	chr15	43600080	43600080	+	T	T	C	Missense_Mutation	SNP	ENST00000450892.7	exon28	c.A5119G	p.S1707G	exonic	ENSG00000242866.10	.	nonsynonymous SNV	ENSG00000242866.10:ENST00000450892.7:exon28:c.A5119G:p.S1707G	15q15.3	C3N-03190	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	N	D	.	T	N	0.249	T	T	D	0.121	0.272	0.614	.	T	T	T	T	T	T	2.150	20.500	0.990	D	N	-0.491	1.194	-0.320	1.524	0.000	0.554	0.588	0.670	0.542	.	4.810	2.480	1.113	1.125	0.607	0.576	0.998	0.988	10	.	.	.	.	STRC	449	1	999	77	0.0715613382899628	NA	TRUE
ENSG00000007545.16	.	BCM	GRCh38.p13	chr16	1656939	1656939	+	C	C	T	Missense_Mutation	SNP	ENST00000397412.8	exon10	c.C2182T	p.R728C	exonic	ENSG00000007545.16	.	nonsynonymous SNV	ENSG00000007545.16:ENST00000397412.8:exon10:c.C2182T:p.R728C	16p13.3	C3N-03190	.	.	.	.	.	.	.	.	rs868557344	13.19	D	D	D	D	D	D	L	.	D	0.659	T	T	D	0.311	.	0.143	1.064	T	D	T	T	D	D	3.936	26.600	0.999	D	D	0.608	6.009	0.548	5.629	0.845	0.635	0.577	0.644	0.636	.	4.430	4.430	2.253	1.026	0.599	1.000	0.984	0.911	557	.	.	.	.	CRAMP1	41	0	78	17	0.178947368421053	TRUE	NA
ENSG00000087245.13	.	BCM	GRCh38.p13	chr16	55488716	55488716	+	G	G	A	Missense_Mutation	SNP	ENST00000219070.9	exon6	c.G1006A	p.A336T	exonic	ENSG00000087245.13	.	nonsynonymous SNV	ENSG00000087245.13:ENST00000219070.9:exon6:c.G1006A:p.A336T	16q12.2	C3N-03190	.	.	.	.	.	.	.	.	rs1019194457	9.20	T	T	D	D	D	D	L	T	N	0.635	T	T	D	0.234	0.244	0.425	1.028	T	T	T	T	D	D	5.763	34	0.998	D	D	0.581	5.737	0.593	6.138	1.000	0.722	0.574	0.710	0.735	.	4.770	4.770	9.951	1.101	0.590	1.000	0.972	0.309	925	Peptidase,_metallopeptidase;Peptidase_M10A,_catalytic_domain;Peptidase_M10,_metallopeptidase	.	.	ID=COSV54605586;OCCURENCE=1(large_intestine)	MMP2	462	1	1032	138	0.117948717948718	TRUE	TRUE
ENSG00000182885.17	.	BCM	GRCh38.p13	chr16	57683939	57683939	+	C	C	T	Missense_Mutation	SNP	ENST00000333493.9	exon9	c.C889T	p.R297W	exonic	ENSG00000182885.17	.	nonsynonymous SNV	ENSG00000182885.17:ENST00000333493.9:exon9:c.C889T:p.R297W	16q21	C3N-03190	2.726e-05	0	0	0.0001	0	3.137e-05	0	0	rs755883919	0.19	T	T	B	B	N	N	.	T	N	0.148	T	T	T	0.032	0.650	0.081	0.152	T	T	T	T	T	T	0.839	9.792	0.873	N	N	-1.194	0.232	-1.189	0.292	0.997	0.554	0.547	0.602	0.564	.	4.990	-1.440	-0.290	-0.765	-1.024	0.000	0.009	0.198	900	GPCR,_family_2-like	.	.	ID=COSV59649953;OCCURENCE=1(prostate)	ADGRG3	29	0	74	4	0.0512820512820513	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7676040	7676040	+	C	C	A	Missense_Mutation	SNP	ENST00000269305.8	exon4	c.G329T	p.R110L	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon4:c.G329T:p.R110L	17p13.1	C3N-03190	1.655e-05	0	0	0	0	1.507e-05	0	6.062e-05	rs11540654	13.20	D	D	P	P	N	N	M	D	D	0.834	D	D	D	0.632	0.837	0.982	1.738	T	D	D	D	D	D	1.791	17.670	0.996	N	N	-0.428	1.322	-0.558	1.110	0.473	0.722	0.702	0.699	0.735	.	4.750	-0.964	0.604	0.138	0.599	0.142	0.811	0.981	434	p53,_DNA-binding_domain	.	.	ID=COSV52662399;OCCURENCE=2(breast),5(liver),1(genital_tract),7(oesophagus),4(large_intestine),1(central_nervous_system),2(ovary),4(haematopoietic_and_lymphoid_tissue),4(stomach),2(soft_tissue),5(urinary_tract),2(pancreas),2(prostate),14(lung),1(thyroid),12(upper_aerodigestive_tract)	TP53	172	0	306	65	0.175202156334232	TRUE	TRUE
ENSG00000173821.19	.	BCM	GRCh38.p13	chr17	80369827	80369827	+	G	G	T	Missense_Mutation	SNP	ENST00000508628.6	exon47	c.G12532T	p.V4178F	exonic	ENSG00000173821.19	.	nonsynonymous SNV	ENSG00000173821.19:ENST00000508628.6:exon47:c.G12532T:p.V4178F	17q25.3	C3N-03190	.	.	.	.	.	.	.	.	.	8.17	D	D	.	.	D	N	.	T	D	0.500	T	T	D	0.280	.	0.517	0.722	T	T	T	T	D	D	3.658	25.200	0.997	D	N	0.471	4.816	0.386	4.262	0.011	0.707	0.725	0.725	0.714	.	5.150	3.160	3.050	1.176	0.676	1.000	0.989	0.995	873	.	.	.	.	RNF213	465	0	974	176	0.15304347826087	TRUE	TRUE
ENSG00000124098.10	.	BCM	GRCh38.p13	chr20	56359006	56359006	+	A	A	G	Translation_Start_Site	SNP	ENST00000371384.4	exon1	c.A1G	p.M1?	exonic	ENSG00000124098.10	.	startloss	ENSG00000124098.10:ENST00000371384.4:exon1:c.A1G:p.M1?	20q13.2	C3N-03190	0	0	0	0	.	0	0	0	rs531290851	8.18	D	D	B	B	N	D	.	T	N	0.811	T	T	D	0.224	0.957	0.171	.	.	T	D	D	D	D	1.926	18.690	0.697	N	N	-0.629	0.936	-0.677	0.933	1.000	0.652	0.552	0.641	0.250	.	3.480	1.080	1.865	1.064	0.649	0.892	0.120	0.055	988	.	.	.	.	FAM210B	153	0	365	60	0.141176470588235	TRUE	NA
ENSG00000175600.15	.	BCM	GRCh38.p13	chr7	40449286	40449286	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000175600.15	ENST00000335693.8:exon10:c.838-1G>A	.	.	7p14.1	C3N-03190	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.135	35	0.995	D	.	1.121	18.476	0.968	17.031	0.740	0.078	0.063	0.084	0.057	0.975	5.460	5.460	6.040	1.172	0.672	1.000	1.000	0.998	814	.	.	.	.	SUGCT	141	0	298	44	0.128654970760234	TRUE	TRUE
ENSG00000092621.12	.	BCM	GRCh38.p13	chr1	119737179	119737179	+	C	C	T	Silent	SNP	ENST00000641597.1	exon11	c.C858T	p.A286A	exonic	ENSG00000092621.12	.	synonymous SNV	ENSG00000092621.12:ENST00000641597.1:exon11:c.C858T:p.A286A	1p12	C3N-03190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PHGDH	415	0	890	172	0.16195856873823	TRUE	TRUE
ENSG00000186487.20	.	BCM	GRCh38.p13	chr2	1922872	1922872	+	G	G	A	Silent	SNP	ENST00000647738.2	exon10	c.C897T	p.Y299Y	exonic	ENSG00000186487.20	.	synonymous SNV	ENSG00000186487.20:ENST00000647738.2:exon10:c.C897T:p.Y299Y	2p25.3	C3N-03190	1.656e-05	0	0	0	0	2.997e-05	0	0	rs377285450	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67706951;OCCURENCE=1(large_intestine),1(kidney)	MYT1L	297	1	716	90	0.11166253101737	TRUE	TRUE
ENSG00000120708.17	.	BCM	GRCh38.p13	chr5	136055715	136055715	+	C	C	T	Silent	SNP	ENST00000442011.7	exon11	c.C1446T	p.H482H	exonic	ENSG00000120708.17	.	synonymous SNV	ENSG00000120708.17:ENST00000442011.7:exon11:c.C1446T:p.H482H	5q31.1	C3N-03190	8.544e-06	0	0	0	0	1.534e-05	0	0	rs766764647	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100526616;OCCURENCE=1(endometrium)	TGFBI	112	0	234	26	0.1	TRUE	NA
ENSG00000113763.12	.	BCM	GRCh38.p13	chr5	176868939	176868939	+	C	C	T	Silent	SNP	ENST00000329542.9	exon5	c.C696T	p.S232S	exonic	ENSG00000113763.12	.	synonymous SNV	ENSG00000113763.12:ENST00000329542.9:exon5:c.C696T:p.S232S	5q35.2	C3N-03190	8.673e-05	0	0	0.0011	0	1.574e-05	0	0	rs553124719	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56173144;OCCURENCE=1(large_intestine)	UNC5A	76	0	177	40	0.184331797235023	TRUE	TRUE
ENSG00000124493.14	.	BCM	GRCh38.p13	chr6	34133140	34133140	+	C	C	T	Silent	SNP	ENST00000538487.7	exon2	c.G357A	p.S119S	exonic	ENSG00000124493.14	.	synonymous SNV	ENSG00000124493.14:ENST00000538487.7:exon2:c.G357A:p.S119S	6p21.31	C3N-03190	0.0001	0.0003	0	0	0	0.0002	0	6.124e-05	rs374197166	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65214119;OCCURENCE=1(large_intestine),1(urinary_tract)	GRM4	241	0	478	78	0.140287769784173	TRUE	TRUE
ENSG00000257923.11	.	BCM	GRCh38.p13	chr7	101916132	101916132	+	C	C	T	Silent	SNP	ENST00000292535.12	exon2	c.C48T	p.T16T	exonic	ENSG00000257923.11	.	synonymous SNV	ENSG00000257923.11:ENST00000292535.12:exon2:c.C48T:p.T16T	7q22.1	C3N-03190	3.295e-05	9.61e-05	8.637e-05	0	0	2.997e-05	0	0	rs376836450	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99472298;OCCURENCE=1(stomach)	CUX1	160	0	415	24	0.0546697038724374	TRUE	NA
ENSG00000117868.17	.	BCM	GRCh38.p13	chr7	158737143	158737143	+	G	G	A	Silent	SNP	ENST00000275418.13	exon20	c.C2304T	p.P768P	exonic	ENSG00000117868.17	.	synonymous SNV	ENSG00000117868.17:ENST00000275418.13:exon20:c.C2304T:p.P768P	7q36.3	C3N-03190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ESYT2	220	0	465	78	0.143646408839779	TRUE	TRUE
ENSG00000111676.15	.	BCM	GRCh38.p13	chr12	6935837	6935837	+	A	A	T	Silent	SNP	ENST00000396684.3	exon5	c.A570T	p.T190T	exonic	ENSG00000111676.15	.	synonymous SNV	ENSG00000111676.15:ENST00000396684.3:exon5:c.A570T:p.T190T	12p13.31	C3N-03190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATN1	167	1	352	57	0.139364303178484	TRUE	TRUE
ENSG00000058335.15	.	BCM	GRCh38.p13	chr15	79046805	79046805	+	G	G	A	Silent	SNP	ENST00000419573.7	exon5	c.C819T	p.A273A	exonic	ENSG00000058335.15	.	synonymous SNV	ENSG00000058335.15:ENST00000419573.7:exon5:c.C819T:p.A273A	15q25.1	C3N-03190	.	.	.	.	.	.	.	.	rs752778899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV69176752;OCCURENCE=2(liver),1(skin),1(endometrium)	RASGRF1	348	1	784	62	0.0732860520094563	TRUE	TRUE
ENSG00000099364.16	.	BCM	GRCh38.p13	chr16	30946863	30946863	+	C	C	T	Silent	SNP	ENST00000380310.6	exon10	c.C1821T	p.C607C	exonic	ENSG00000099364.16	.	synonymous SNV	ENSG00000099364.16:ENST00000380310.6:exon10:c.C1821T:p.C607C	16p11.2	C3N-03190	1.896e-05	0	0	0	0	0	0	0.0001	rs749247594	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBXL19	356	0	658	160	0.19559902200489	TRUE	NA
ENSG00000103154.9	.	BCM	GRCh38.p13	chr16	83972165	83972165	+	G	G	T	Silent	SNP	ENST00000305202.8	exon2	c.G216T	p.A72A	exonic	ENSG00000103154.9	.	synonymous SNV	ENSG00000103154.9:ENST00000305202.8:exon2:c.G216T:p.A72A	16q23.3	C3N-03190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100534054;OCCURENCE=1(skin)	NECAB2	347	0	807	154	0.160249739854318	TRUE	TRUE
ENSG00000160994.4	.	BCM	GRCh38.p13	chr19	15011269	15011269	+	C	C	T	Silent	SNP	ENST00000292574.4	exon1	c.C444T	p.N148N	exonic	ENSG00000160994.4	.	synonymous SNV	ENSG00000160994.4:ENST00000292574.4:exon1:c.C444T:p.N148N	19p13.12	C3N-03190	.	.	.	.	.	.	.	.	rs537607141	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC105	120	0	248	41	0.141868512110727	TRUE	NA
ENSG00000198300.14	.	BCM	GRCh38.p13	chr19	56815217	56815217	+	G	G	A	Silent	SNP	ENST00000326441.15	exon10	c.C3225T	p.S1075S	exonic	ENSG00000198300.14	.	synonymous SNV	ENSG00000198300.14:ENST00000326441.15:exon10:c.C3225T:p.S1075S	19q13.43	C3N-03190	5.771e-05	0.0003	0.0002	0.0001	0	0	0	6.08e-05	rs146308462	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99688733;OCCURENCE=1(stomach)	PEG3	92	0	203	14	0.0645161290322581	TRUE	NA
ENSG00000198959.12	.	BCM	GRCh38.p13	chr20	38132602	38132602	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000198959.12	.	.	.	20q11.23	C3N-03190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TGM2	105	0	182	11	0.0569948186528497	TRUE	NA
ENSG00000179253.3	.	BCM	GRCh38.p13	chr20	61718976	61718976	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000179253.3	.	.	.	20q13.33	C3N-03190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL162457.1	231	0	483	110	0.185497470489039	TRUE	NA
ENSG00000162728.5	.	BCM	GRCh38.p13	chr1	160084469	160084469	+	T	T	G	Missense_Mutation	SNP	ENST00000368088.4	exon2	c.T439G	p.S147A	exonic	ENSG00000162728.5	.	nonsynonymous SNV	ENSG00000162728.5:ENST00000368088.4:exon2:c.T439G:p.S147A	1q23.2	C3N-00516	.	.	.	.	.	.	.	.	.	15.20	T	T	P	P	D	D	M	D	D	0.644	D	D	D	0.771	0.602	0.835	.	T	D	D	D	D	D	3.501	24.700	0.985	D	D	0.486	4.931	0.467	4.873	1.000	0.598	0.552	0.607	0.639	.	4.600	3.380	6.058	1.138	0.665	1.000	1.000	1.000	787	.	.	.	.	KCNJ9	280	1	599	126	0.173793103448276	TRUE	TRUE
ENSG00000116962.15	.	BCM	GRCh38.p13	chr1	236032428	236032428	+	C	C	T	Missense_Mutation	SNP	ENST00000264187.7	exon6	c.G1510A	p.G504R	exonic	ENSG00000116962.15	.	nonsynonymous SNV	ENSG00000116962.15:ENST00000264187.7:exon6:c.G1510A:p.G504R	1q42.3	C3N-00516	0.0015	0	0.0002	0.0148	0.0026	0.0002	0.0022	0.0008	rs78916782	11.19	D	D	D	D	D	D	M	T	D	0.721	T	T	.	0.384	.	0.610	0.839	T	T	T	T	T	D	3.637	25.200	0.999	D	D	0.722	7.435	0.675	7.307	1.000	0.706	0.709	0.710	0.714	.	5.870	4.960	5.862	1.026	0.599	1.000	0.572	0.964	475	G2_nidogen/fibulin_G2F	.	.	.	NID1	208	0	337	50	0.129198966408269	TRUE	NA
ENSG00000172554.12	.	BCM	GRCh38.p13	chr2	1267474	1267474	+	G	G	A	Missense_Mutation	SNP	ENST00000308624.10	exon14	c.G1187A	p.G396E	exonic	ENSG00000172554.12	.	nonsynonymous SNV	ENSG00000172554.12:ENST00000308624.10:exon14:c.G1187A:p.G396E	2p25.3	C3N-00516	8.466e-06	0.0001	0	0	0	0	0	0	rs768494785	12.20	T	D	D	P	D	D	M	T	D	0.790	T	D	D	0.476	0.492	0.756	0.458	T	T	T	T	D	D	2.940	23.300	0.977	D	D	0.085	2.826	-0.034	2.248	0.742	0.615	0.574	0.659	0.564	.	4.610	3.730	7.547	1.062	0.676	1.000	0.016	0.014	952	.	.	.	.	SNTG2	562	0	655	189	0.2239336492891	TRUE	NA
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140323991	140323991	+	C	C	T	Missense_Mutation	SNP	ENST00000389484.8	exon81	c.G12416A	p.R4139Q	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon81:c.G12416A:p.R4139Q	2q22.1	C3N-00516	8.296e-06	0	0	0	0	0	0	6.059e-05	rs755807737	12.20	D	D	B	B	D	D	M	D	N	0.552	D	D	D	0.329	0.583	0.499	0.319	T	T	T	T	D	D	3.230	23.900	0.998	D	N	-0.011	2.473	0.128	2.851	0.016	0.487	0.574	0.574	0.564	.	5.670	4.790	2.620	1.026	0.599	1.000	0.999	0.998	939	.	.	.	ID=COSV104701802;OCCURENCE=1(skin)	LRP1B	76	0	295	17	0.0544871794871795	TRUE	NA
ENSG00000178385.15	.	BCM	GRCh38.p13	chr2	207976933	207976933	+	C	C	A	Missense_Mutation	SNP	ENST00000427836.8	exon3	c.G1264T	p.D422Y	exonic	ENSG00000178385.15	.	nonsynonymous SNV	ENSG00000178385.15:ENST00000427836.8:exon3:c.G1264T:p.D422Y	2q33.3	C3N-00516	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	D	D	L	T	N	0.723	T	T	T	0.221	0.662	0.208	0.704	T	T	T	T	D	.	3.798	25.800	0.996	D	D	0.303	3.793	0.418	4.485	1.000	0.615	0.654	0.659	0.636	.	5.820	5.820	4.112	1.026	0.599	1.000	0.992	0.946	739	Pleckstrin_homology_domain	.	.	.	PLEKHM3	340	0	406	125	0.235404896421846	TRUE	TRUE
ENSG00000170266.16	.	BCM	GRCh38.p13	chr3	33016813	33016813	+	T	T	C	Missense_Mutation	SNP	ENST00000307363.10	exon14	c.A1375G	p.N459D	exonic	ENSG00000170266.16	.	nonsynonymous SNV	ENSG00000170266.16:ENST00000307363.10:exon14:c.A1375G:p.N459D	3p22.3	C3N-00516	.	.	.	.	.	.	.	.	.	3.18	T	T	B	B	N	N	.	D	N	0.240	T	D	D	0.176	0.451	0.857	0.267	T	.	T	T	T	T	-0.720	0.039	0.911	N	N	-1.237	0.202	-1.300	0.209	0.426	0.732	0.725	0.744	0.714	.	5.890	-5.180	0.031	-0.211	0.665	0.000	0.001	0.043	819	.	.	.	.	GLB1	207	0	292	23	0.073015873015873	TRUE	TRUE
ENSG00000173706.14	.	BCM	GRCh38.p13	chr3	125012757	125012757	+	G	G	A	Missense_Mutation	SNP	ENST00000311127.9	exon6	c.C2822T	p.S941L	exonic	ENSG00000173706.14	.	nonsynonymous SNV	ENSG00000173706.14:ENST00000311127.9:exon6:c.C2822T:p.S941L	3q21.2	C3N-00516	.	.	.	.	.	.	.	.	.	8.20	D	D	B	B	U	N	M	D	D	0.131	T	D	D	0.114	0.318	0.829	0.280	T	T	T	T	D	T	1.998	19.240	0.973	N	N	-0.447	1.283	-0.519	1.172	1.000	0.707	0.725	0.609	0.714	.	4.780	2.970	1.622	1.176	0.676	0.010	0.051	0.480	496	.	.	.	.	HEG1	363	0	598	62	0.0939393939393939	TRUE	TRUE
ENSG00000155890.4	.	BCM	GRCh38.p13	chr3	140682967	140682967	+	G	G	A	Missense_Mutation	SNP	ENST00000286349.4	exon2	c.G847A	p.E283K	exonic	ENSG00000155890.4	.	nonsynonymous SNV	ENSG00000155890.4:ENST00000286349.4:exon2:c.G847A:p.E283K	3q23	C3N-00516	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.225	T	T	T	0.085	0.457	0.468	0.259	T	T	T	T	T	T	2.317	21.700	0.995	D	N	-0.280	1.664	-0.117	1.998	0.000	0.487	0.574	0.574	0.564	.	5.460	2.460	2.099	1.176	0.676	0.989	0.985	0.987	561	.	.	.	ID=COSV53883465;OCCURENCE=1(breast),1(urinary_tract)	TRIM42	524	1	893	52	0.055026455026455	TRUE	TRUE
ENSG00000038382.20	.	BCM	GRCh38.p13	chr5	14479976	14479976	+	G	G	T	Missense_Mutation	SNP	ENST00000344204.9	exon43	c.G6301T	p.V2101L	exonic	ENSG00000038382.20	.	nonsynonymous SNV	ENSG00000038382.20:ENST00000344204.9:exon43:c.G6301T:p.V2101L	5p15.2	C3N-00516	.	.	.	.	.	.	.	.	.	13.20	D	D	B	B	D	D	H	T	N	0.815	T	T	D	0.453	0.715	0.846	0.831	D	T	D	D	D	D	3.352	24.300	0.998	D	D	0.571	5.639	0.641	6.772	1.000	0.732	0.725	0.744	0.714	.	5.900	5.900	8.186	1.176	0.676	1.000	0.998	0.991	764	Dbl_homology_(DH)_domain	.	.	.	TRIO	220	0	309	54	0.148760330578512	TRUE	TRUE
ENSG00000253159.3	.	BCM	GRCh38.p13	chr5	141430938	141430938	+	C	C	T	Missense_Mutation	SNP	ENST00000252085.4	exon1	c.C179T	p.A60V	exonic	ENSG00000253159.3	.	nonsynonymous SNV	ENSG00000253159.3:ENST00000252085.4:exon1:c.C179T:p.A60V	5q31.3	C3N-00516	.	.	.	.	.	.	.	.	.	2.18	D	T	B	B	.	N	L	T	D	0.083	T	T	T	0.042	0.559	0.376	.	.	T	T	T	T	T	1.239	13.940	0.986	N	N	-0.538	1.102	-0.560	1.107	1.000	0.581	0.552	0.576	0.373	.	5.550	2.610	-0.116	-0.352	0.599	0.000	0.021	0.089	818	Cadherin-like;Cadherin,_N-terminal	.	.	ID=COSV52747320;OCCURENCE=1(large_intestine),1(skin)	PCDHGA12	101	1	104	6	0.0545454545454545	TRUE	NA
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	3190004	3190004	+	G	G	A	Missense_Mutation	SNP	ENST00000635120.2	exon34	c.C5306T	p.P1769L	exonic	ENSG00000183117.19	.	nonsynonymous SNV	ENSG00000183117.19:ENST00000635120.2:exon34:c.C5306T:p.P1769L	8p23.2	C3N-00516	1.974e-05	0	0	0	0	3.652e-05	0	0	rs771790436	11.19	D	D	D	D	D	D	.	T	D	0.785	T	T	T	0.353	0.572	0.597	.	T	T	T	T	D	D	3.137	23.700	0.999	D	D	0.388	4.272	0.354	4.046	0.408	0.554	0.574	0.618	0.564	.	5.340	3.410	7.772	1.176	0.665	1.000	0.433	0.295	934	Sushi/SCR/CCP_domain	.	.	.	CSMD1	361	1	648	154	0.192019950124688	TRUE	NA
ENSG00000156687.11	.	BCM	GRCh38.p13	chr8	35722260	35722260	+	G	G	A	Missense_Mutation	SNP	ENST00000404895.7	exon9	c.G1168A	p.V390I	exonic	ENSG00000156687.11	.	nonsynonymous SNV	ENSG00000156687.11:ENST00000404895.7:exon9:c.G1168A:p.V390I	8p12	C3N-00516	0.0014	0.0004	0.0002	0.0001	0.0002	0.0003	0	0.0085	rs144971419	3.20	T	T	B	B	N	D	N	T	N	0.269	T	T	T	0.039	.	0.093	0.368	T	T	T	T	T	D	0.960	11.120	0.988	D	N	-0.603	0.982	-0.435	1.311	0.971	0.719	0.574	0.723	0.564	.	5.710	3.900	0.934	1.175	0.676	0.624	0.190	0.493	606	.	.	.	ID=COSV54792896;OCCURENCE=1(large_intestine)	UNC5D	241	0	412	34	0.0762331838565022	TRUE	TRUE
ENSG00000136997.20	.	BCM	GRCh38.p13	chr8	127738927	127738927	+	C	C	G	Missense_Mutation	SNP	ENST00000377970.6	exon2	c.C665G	p.S222C	exonic	ENSG00000136997.20	.	nonsynonymous SNV	ENSG00000136997.20:ENST00000377970.6:exon2:c.C665G:p.S222C	8q24.21	C3N-00516	.	.	.	.	.	.	.	.	.	10.19	D	D	D	D	N	N	L	T	N	0.400	T	D	D	0.251	0.332	0.911	.	T	T	D	T	D	D	2.540	22.500	0.992	D	.	0.609	6.016	0.548	5.633	1.000	0.789	0.672	0.768	0.562	.	4.340	4.340	3.116	0.959	0.520	1.000	0.997	0.888	962	Transcription_regulator_Myc,_N-terminal	.	.	.	MYC	122	0	182	44	0.194690265486726	TRUE	TRUE
ENSG00000099810.21	.	BCM	GRCh38.p13	chr9	21818198	21818198	+	G	G	C	Missense_Mutation	SNP	ENST00000404796.3	exon4	c.G343C	p.D115H	exonic	ENSG00000099810.21;ENSG00000264545.2	.	nonsynonymous SNV	ENSG00000264545.2:ENST00000404796.3:exon4:c.G343C:p.D115H,ENSG00000099810.21:ENST00000644715.2:exon4:c.G343C:p.D115H	9p21.3	C3N-00516	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	N	D	H	T	D	0.957	D	D	D	0.691	0.880	0.911	0.603	T	D	D	D	D	D	4.116	27.900	0.996	D	D	1.013	14.326	0.894	13.500	1.000	0.672	0.654	0.702	0.636	.	5.100	5.100	9.327	1.176	0.676	1.000	1.000	0.987	914	Nucleoside_phosphorylase_domain	.	.	.	MTAP	368	0	308	73	0.191601049868766	TRUE	TRUE
ENSG00000159069.14	.	BCM	GRCh38.p13	chr9	136942587	136942587	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000325285.8	exon5	c.634dupA	p.I212Nfs*53	exonic	ENSG00000159069.14	.	frameshift insertion	ENSG00000159069.14:ENST00000325285.8:exon5:c.634dupA:p.I212Nfs*53	9q34.3	C3N-00516	9.3e-06	0	0	0	0	1.696e-05	0	0	rs762193986	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FBXW5	NA	NA	NA	NA	NA	NA	NA
ENSG00000151025.11	.	BCM	GRCh38.p13	chr10	25598948	25598948	+	C	C	T	Missense_Mutation	SNP	ENST00000376351.4	exon11	c.C3322T	p.R1108C	exonic	ENSG00000151025.11	.	nonsynonymous SNV	ENSG00000151025.11:ENST00000376351.4:exon11:c.C3322T:p.R1108C	10p12.1	C3N-00516	8.265e-06	0	8.648e-05	0	0	0	0	0	rs372238950	0.20	T	T	B	B	N	N	N	T	N	0.064	T	T	T	0.128	.	0.043	0.131	T	T	T	T	T	T	0.038	1.590	0.691	N	N	-1.353	0.138	-1.408	0.147	0.003	0.487	0.574	0.574	0.564	.	5.790	-6.540	-0.857	-0.239	0.599	0.000	0.000	0.001	898	.	.	.	ID=COSV66267514;OCCURENCE=1(ovary),2(skin)	GPR158	294	0	487	99	0.168941979522184	TRUE	TRUE
ENSG00000197467.15	.	BCM	GRCh38.p13	chr10	69935390	69935390	+	C	C	T	Missense_Mutation	SNP	ENST00000398978.8	exon31	c.C1736T	p.P579L	exonic	ENSG00000197467.15	.	nonsynonymous SNV	ENSG00000197467.15:ENST00000398978.8:exon31:c.C1736T:p.P579L	10q22.1	C3N-00516	4.569e-05	0	0	0	0	8.943e-05	0	0	rs766119482	10.20	D	T	B	B	N	D	M	D	D	0.433	T	T	D	0.439	0.376	0.884	0.137	T	D	D	D	T	T	1.576	16.220	0.762	D	N	0.204	3.321	0.040	2.500	0.003	0.706	0.547	0.659	0.613	.	5.320	1.320	1.269	-0.280	-0.173	1.000	0.835	0.241	630	.	.	.	.	COL13A1	70	0	121	22	0.153846153846154	TRUE	NA
ENSG00000182272.12	.	BCM	GRCh38.p13	chr11	376780	376780	+	G	G	A	Missense_Mutation	SNP	ENST00000329962.11	exon14	c.G1657A	p.V553I	exonic	ENSG00000182272.12	.	nonsynonymous SNV	ENSG00000182272.12:ENST00000329962.11:exon14:c.G1657A:p.V553I	11p15.5	C3N-00516	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	T	N	0.120	T	T	D	0.047	0.281	0.068	0.805	D	T	T	T	T	T	0.506	6.564	0.869	N	N	-0.841	0.598	-0.793	0.767	0.021	0.696	0.547	0.723	0.605	.	3.360	1.450	0.744	0.117	0.482	0.014	0.584	0.047	900	.	.	.	.	B4GALNT4	74	0	116	24	0.171428571428571	TRUE	NA
ENSG00000110665.12	.	BCM	GRCh38.p13	chr11	2300570	2300570	+	C	C	T	Missense_Mutation	SNP	ENST00000381153.8	exon2	c.G97A	p.E33K	exonic	ENSG00000110665.12	.	nonsynonymous SNV	ENSG00000110665.12:ENST00000381153.8:exon2:c.G97A:p.E33K	11p15.5	C3N-00516	.	.	.	.	.	.	.	.	rs951446970	0.17	T	T	B	B	.	N	N	.	N	0.077	T	T	T	0.003	0.232	0.241	.	.	T	T	T	T	T	-0.368	0.224	0.715	N	N	-1.866	0.017	-1.944	0.018	1.000	0.487	0.586	0.578	0.613	.	1.190	-2.390	-3.166	-1.582	-1.048	0.000	0.000	0.000	988	.	.	.	.	C11orf21	202	0	267	16	0.0565371024734982	TRUE	NA
ENSG00000175356.13	.	BCM	GRCh38.p13	chr11	9069424	9069424	+	C	C	T	Missense_Mutation	SNP	ENST00000309263.7	exon5	c.G589A	p.A197T	exonic	ENSG00000175356.13	.	nonsynonymous SNV	ENSG00000175356.13:ENST00000309263.7:exon5:c.G589A:p.A197T	11p15.4	C3N-00516	3.298e-05	0	8.639e-05	0	0	4.501e-05	0	0	rs370871651	9.20	D	T	P	B	D	D	N	D	D	0.479	T	T	T	0.537	.	0.881	0.222	T	T	T	D	T	D	3.096	23.600	0.997	D	D	0.174	3.191	0.276	3.581	1.000	0.659	0.547	0.725	0.542	.	4.790	4.790	2.990	1.026	0.599	0.992	0.927	0.950	643	EGF-like_domain	.	.	ID=COSV58542229;OCCURENCE=1(stomach)	SCUBE2	271	0	572	34	0.0561056105610561	TRUE	TRUE
ENSG00000082175.15	.	BCM	GRCh38.p13	chr11	101091876	101091876	+	C	C	T	Missense_Mutation	SNP	ENST00000325455.10	exon3	c.G1790A	p.G597E	exonic	ENSG00000082175.15	.	nonsynonymous SNV	ENSG00000082175.15:ENST00000325455.10:exon3:c.G1790A:p.G597E	11q22.1	C3N-00516	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	L	D	D	0.695	D	D	D	0.868	0.676	0.977	.	D	D	D	D	D	D	4.789	33	0.998	D	D	0.755	7.964	0.789	9.818	1.000	0.487	0.574	0.574	0.564	.	5.810	5.810	7.810	1.026	0.599	1.000	0.996	0.979	897	Zinc_finger,_nuclear_hormone_receptor-type;Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	PGR	295	0	450	53	0.105367793240557	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-00516	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	330	1	490	162	0.248466257668712	TRUE	TRUE
ENSG00000139329.5	.	BCM	GRCh38.p13	chr12	91108276	91108276	+	C	C	T	Missense_Mutation	SNP	ENST00000266718.5	exon2	c.G704A	p.R235H	exonic	ENSG00000139329.5	.	nonsynonymous SNV	ENSG00000139329.5:ENST00000266718.5:exon2:c.G704A:p.R235H	12q21.33	C3N-00516	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	D	D	N	T	D	0.259	T	T	D	0.317	0.500	0.781	0.808	T	D	T	T	D	D	3.642	25.200	0.999	D	D	0.432	4.551	0.454	4.767	1.000	0.554	0.547	0.574	0.621	.	5.570	4.680	3.860	1.026	0.599	1.000	1.000	0.978	900	.	.	.	ID=COSV57129387;OCCURENCE=1(breast),1(central_nervous_system)	LUM	197	0	390	36	0.0845070422535211	TRUE	TRUE
ENSG00000184916.9	.	BCM	GRCh38.p13	chr14	105144998	105144998	+	G	G	A	Missense_Mutation	SNP	ENST00000331782.8	exon24	c.C3016T	p.R1006W	exonic	ENSG00000184916.9	.	nonsynonymous SNV	ENSG00000184916.9:ENST00000331782.8:exon24:c.C3016T:p.R1006W	14q32.33	C3N-00516	.	.	.	.	.	.	.	.	.	11.20	D	D	D	P	U	N	M	D	D	0.567	T	D	D	0.375	.	0.610	0.695	T	D	T	T	D	D	3.595	25.000	0.999	N	N	-0.055	2.320	-0.174	1.848	0.952	0.672	0.588	0.645	0.711	.	3.830	3.830	0.410	1.083	0.618	0.000	0.229	0.228	982	.	.	.	.	JAG2	494	0	713	56	0.0728218465539662	TRUE	NA
ENSG00000226174.7	.	BCM	GRCh38.p13	chr14	105411495	105411495	+	G	G	T	Missense_Mutation	SNP	ENST00000451127.3	exon3	c.G278T	p.R93M	exonic	ENSG00000226174.7	.	nonsynonymous SNV	ENSG00000226174.7:ENST00000451127.3:exon3:c.G278T:p.R93M	14q32.33	C3N-00516	.	.	.	.	.	.	.	.	.	4.18	D	D	B	B	.	N	N	.	D	0.301	T	T	D	0.241	0.222	0.030	.	T	T	T	T	T	T	1.491	15.680	0.720	N	N	-1.495	0.083	-1.620	0.070	1.000	0.583	0.541	0.504	0.619	.	2.620	-5.240	-0.031	0.803	0.517	0.005	0.018	0.009	964	.	.	.	.	TEX22	21	0	16	3	0.157894736842105	TRUE	NA
ENSG00000007541.17	.	BCM	GRCh38.p13	chr16	580970	580970	+	C	C	T	Missense_Mutation	SNP	ENST00000026218.9	exon9	c.C1529T	p.A510V	exonic	ENSG00000007541.17	.	nonsynonymous SNV	ENSG00000007541.17:ENST00000026218.9:exon9:c.C1529T:p.A510V	16p13.3	C3N-00516	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	L	T	N	0.651	T	T	D	0.153	0.245	0.729	0.482	T	T	T	T	D	D	4.212	28.800	0.996	D	D	0.312	3.840	0.326	3.871	1.000	0.788	0.694	0.000	0.714	.	5.220	5.220	7.585	1.026	0.599	1.000	0.303	0.298	824	.	.	.	ID=COSV50314907;OCCURENCE=1(large_intestine),1(pancreas),1(prostate)	PIGQ	215	0	370	79	0.175946547884187	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675088	7675088	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G524A	p.R175H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G524A:p.R175H	17p13.1	C3N-00516	8.243e-06	0	0	0	0	1.499e-05	0	0	rs28934578	19.20	D	D	D	D	D	A	M	D	D	0.938	D	D	D	0.922	0.986	0.997	1.101	T	D	D	D	D	D	2.987	23.400	0.999	D	D	0.740	7.720	0.711	7.954	1.000	0.722	0.698	0.698	0.735	.	5.410	5.410	6.163	1.026	0.599	1.000	0.996	0.919	434	p53,_DNA-binding_domain	.	.	ID=COSV52661038;OCCURENCE=13(salivary_gland),172(breast),8(penis),1(peritoneum),14(liver),118(oesophagus),6(adrenal_gland),1(meninges),5(cervix),604(large_intestine),116(central_nervous_system),23(biliary_tract),94(ovary),9(vulva),2(pleura),5(bone),6(NS),124(stomach),74(haematopoietic_and_lymphoid_tissue),14(soft_tissue),21(kidney),38(urinary_tract),75(pancreas),10(skin),28(prostate),47(lung),14(thyroid),109(upper_aerodigestive_tract),1(testis),1(eye),3(small_intestine),31(endometrium)	TP53	503	0	557	213	0.276623376623377	TRUE	TRUE
ENSG00000108244.17	.	BCM	GRCh38.p13	chr17	40930079	40930079	+	G	G	C	Missense_Mutation	SNP	ENST00000209718.8	exon4	c.C497G	p.S166C	exonic	ENSG00000108244.17	.	nonsynonymous SNV	ENSG00000108244.17:ENST00000209718.8:exon4:c.C497G:p.S166C	17q21.2	C3N-00516	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	D	N	M	D	N	0.155	D	D	D	0.383	0.500	0.788	0.566	T	D	T	T	D	T	3.481	24.600	0.804	D	N	0.625	6.185	0.617	6.444	0.226	0.487	0.563	0.574	0.530	.	5.740	5.740	3.463	1.176	0.618	0.867	0.999	1.000	150	Intermediate_filament,_rod_domain	.	.	.	KRT23	93	1	157	71	0.31140350877193	TRUE	TRUE
ENSG00000142347.19	.	BCM	GRCh38.p13	chr19	8544443	8544443	+	C	C	T	Missense_Mutation	SNP	ENST00000644032.2	exon14	c.G1378A	p.V460I	exonic	ENSG00000142347.19	.	nonsynonymous SNV	ENSG00000142347.19:ENST00000644032.2:exon14:c.G1378A:p.V460I	19p13.2	C3N-00516	0.0001	0	0.0002	0	0	1.636e-05	0.0013	0.0005	rs758097575	6.20	T	T	B	B	U	D	N	D	N	0.221	T	T	D	0.243	.	0.538	0.448	T	T	T	T	T	D	1.473	15.560	0.896	D	D	-0.724	0.773	-0.494	1.211	0.702	0.646	0.634	0.645	0.613	.	3.490	3.490	1.686	0.883	0.537	0.970	0.982	0.790	624	Class_I_myosin,_motor_domain;Myosin_head,_motor_domain	.	.	ID=COSV57792161;OCCURENCE=1(oesophagus),1(large_intestine)	MYO1F	228	0	430	33	0.0712742980561555	TRUE	TRUE
ENSG00000170929.6	.	BCM	GRCh38.p13	chr19	9093605	9093605	+	G	G	T	Missense_Mutation	SNP	ENST00000641627.1	exon2	c.G361T	p.D121Y	exonic	ENSG00000170929.6	.	nonsynonymous SNV	ENSG00000170929.6:ENST00000641627.1:exon2:c.G361T:p.D121Y	19p13.2	C3N-00516	.	.	.	.	.	.	.	.	.	14.20	D	D	D	P	D	D	H	T	D	0.792	D	T	T	0.432	0.605	0.838	0.155	T	T	D	D	D	D	2.515	22.500	0.991	D	D	0.430	4.538	0.235	3.362	0.024	0.554	0.574	0.618	0.564	.	3.900	2.860	6.653	0.009	-0.118	1.000	0.061	0.045	970	GPCR,_rhodopsin-like,_7TM	.	.	.	OR1M1	325	0	484	57	0.105360443622921	TRUE	TRUE
ENSG00000037757.14	.	BCM	GRCh38.p13	chr19	13768570	13768570	+	G	G	C	Missense_Mutation	SNP	ENST00000040663.8	exon4	c.G557C	p.R186P	exonic	ENSG00000037757.14	.	nonsynonymous SNV	ENSG00000037757.14:ENST00000040663.8:exon4:c.G557C:p.R186P	19p13.13	C3N-00516	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.958	D	T	D	0.664	0.763	0.700	1.050	T	D	D	D	D	D	4.179	28.500	0.996	D	D	0.967	12.921	0.816	10.616	1.000	0.707	0.725	0.723	0.714	.	5.430	5.430	8.939	0.195	-0.213	1.000	0.849	0.005	958	.	.	.	.	MRI1	122	0	179	38	0.175115207373272	TRUE	TRUE
ENSG00000171777.16	.	BCM	GRCh38.p13	chr19	38413413	38413413	+	G	G	A	Missense_Mutation	SNP	ENST00000615439.5	exon10	c.C1292T	p.P431L	exonic	ENSG00000171777.16	.	nonsynonymous SNV	ENSG00000171777.16:ENST00000615439.5:exon10:c.C1292T:p.P431L	19q13.2	C3N-00516	1.304e-05	0	0	0	0.0003	0	0	0	rs769519232	18.20	D	D	D	D	D	D	M	T	D	0.851	D	D	D	0.548	.	0.843	0.987	T	D	D	D	D	D	4.018	27.100	0.999	D	D	0.955	12.560	0.876	12.750	1.000	0.615	0.634	0.659	0.613	.	5.250	5.250	9.211	1.176	0.676	1.000	0.804	0.762	603	Ras_guanine-nucleotide_exchange_factors_catalytic_domain	.	.	ID=COSV53039354;OCCURENCE=1(large_intestine),1(skin)	RASGRP4	279	0	404	116	0.223076923076923	TRUE	TRUE
ENSG00000167380.16	.	BCM	GRCh38.p13	chr19	44177028	44177028	+	G	G	A	Missense_Mutation	SNP	ENST00000590089.5	exon7	c.G1766A	p.C589Y	exonic	ENSG00000167380.16	.	nonsynonymous SNV	ENSG00000167380.16:ENST00000590089.5:exon7:c.G1766A:p.C589Y	19q13.31	C3N-00516	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	H	D	D	0.613	D	D	D	0.646	0.714	0.967	0.171	D	D	D	D	D	T	4.140	28.100	0.998	D	D	0.892	10.835	0.799	10.086	1.000	0.707	0.702	0.725	0.636	.	4.100	4.100	7.711	1.158	0.656	1.000	0.925	0.997	906	Zinc_finger_C2H2-type	.	.	.	ZNF226	268	0	322	136	0.296943231441048	TRUE	TRUE
ENSG00000124198.9	.	BCM	GRCh38.p13	chr20	49018910	49018910	+	A	A	C	Missense_Mutation	SNP	ENST00000371917.5	exon34	c.A4536C	p.L1512F	exonic	ENSG00000124198.9	.	nonsynonymous SNV	ENSG00000124198.9:ENST00000371917.5:exon34:c.A4536C:p.L1512F	20q13.13	C3N-00516	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	D	L	T	N	0.501	T	T	T	0.045	0.167	0.251	0.501	T	T	T	T	T	D	1.464	15.500	0.822	D	N	-0.428	1.324	-0.320	1.523	0.002	0.707	0.725	0.725	0.714	.	4.720	1.180	0.440	0.325	-0.043	0.993	1.000	0.997	934	.	.	.	.	ARFGEF2	451	0	685	41	0.0564738292011019	TRUE	TRUE
ENSG00000171587.15	.	BCM	GRCh38.p13	chr21	40369117	40369117	+	C	C	T	Missense_Mutation	SNP	ENST00000400454.6	exon4	c.G637A	p.A213T	exonic	ENSG00000171587.15	.	nonsynonymous SNV	ENSG00000171587.15:ENST00000400454.6:exon4:c.G637A:p.A213T	21q22.2	C3N-00516	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	L	T	D	0.811	T	T	T	0.289	0.522	0.613	1.447	D	T	T	T	D	D	3.875	26.200	0.999	D	D	0.842	9.661	0.828	11.022	1.000	0.487	0.574	0.574	0.564	.	6.070	6.070	7.813	1.026	0.599	1.000	0.954	0.984	970	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV68648785;OCCURENCE=1(breast)	DSCAM	118	0	182	21	0.103448275862069	TRUE	TRUE
ENSG00000160282.14	.	BCM	GRCh38.p13	chr21	46138615	46138615	+	G	G	A	Missense_Mutation	SNP	ENST00000397746.8	exon12	c.C1336T	p.R446W	exonic	ENSG00000160282.14	.	nonsynonymous SNV	ENSG00000160282.14:ENST00000397746.8:exon12:c.C1336T:p.R446W	21q22.3	C3N-00516	8.243e-05	0	0.0002	0.0002	0	4.965e-05	0	0.0002	rs201966668	7.20	T	D	D	P	U	N	M	T	N	0.350	T	T	T	0.089	.	0.732	0.278	T	T	D	D	T	D	3.662	25.300	0.999	N	D	0.117	2.954	0.020	2.430	1.000	0.646	0.588	0.645	0.542	.	4.390	3.350	0.498	1.040	0.676	0.000	0.553	0.768	982	Cyclodeaminase/cyclohydrolase	.	.	ID=COSV52428035;OCCURENCE=1(pancreas)	FTCD	377	0	758	41	0.0513141426783479	TRUE	TRUE
ENSG00000100191.5	.	BCM	GRCh38.p13	chr22	32254154	32254154	+	C	C	T	Missense_Mutation	SNP	ENST00000266086.5	exon2	c.G195A	p.M65I	exonic	ENSG00000100191.5	.	nonsynonymous SNV	ENSG00000100191.5:ENST00000266086.5:exon2:c.G195A:p.M65I	22q12.3	C3N-00516	.	.	.	.	.	.	.	.	.	6.20	D	T	B	B	D	N	L	D	N	0.237	T	D	T	0.327	0.731	0.675	0.178	T	T	T	T	T	D	1.549	16.050	0.939	D	N	-0.510	1.156	-0.513	1.181	0.000	0.554	0.574	0.547	0.621	.	5.390	2.090	5.552	0.068	-0.182	1.000	0.009	0.012	309	.	.	.	.	SLC5A4	512	0	624	177	0.220973782771536	TRUE	TRUE
ENSG00000102038.15	.	BCM	GRCh38.p13	chrX	129481100	129481100	+	C	C	T	Missense_Mutation	SNP	ENST00000371122.8	exon18	c.G2303A	p.R768H	exonic	ENSG00000102038.15	.	nonsynonymous SNV	ENSG00000102038.15:ENST00000371122.8:exon18:c.G2303A:p.R768H	Xq25	C3N-00516	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	M	D	D	0.594	D	D	D	0.848	0.546	0.952	1.765	D	T	D	D	D	D	4.070	27.500	1.000	D	.	.	.	.	.	1.000	.	.	.	.	.	5.810	5.810	7.905	1.026	0.599	1.000	1.000	0.999	253	ISWI,_HAND_domain	.	.	ID=COSV100946432;OCCURENCE=1(large_intestine)	SMARCA1	146	0	133	20	0.130718954248366	TRUE	NA
ENSG00000144229.12	.	BCM	GRCh38.p13	chr2	137642573	137642573	+	C	C	T	Silent	SNP	ENST00000409968.6	exon21	c.C3885T	p.T1295T	exonic	ENSG00000144229.12	.	synonymous SNV	ENSG00000144229.12:ENST00000409968.6:exon21:c.C3885T:p.T1295T	2q22.1	C3N-00516	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	THSD7B	241	0	396	35	0.0812064965197216	TRUE	TRUE
ENSG00000204681.11	.	BCM	GRCh38.p13	chr6	29607177	29607177	+	G	G	A	Silent	SNP	ENST00000377034.9	exon17	c.C2034T	p.Y678Y	exonic	ENSG00000204681.11	.	synonymous SNV	ENSG00000204681.11:ENST00000377034.9:exon17:c.C2034T:p.Y678Y	6p22.1	C3N-00516	1.647e-05	0	0	0	0	2.997e-05	0	0	rs758589287	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63541979;OCCURENCE=2(large_intestine),1(pancreas),2(lung)	GABBR1	270	0	430	30	0.0652173913043478	TRUE	TRUE
ENSG00000112175.8	.	BCM	GRCh38.p13	chr6	55874728	55874728	+	G	G	A	Silent	SNP	ENST00000370830.4	exon1	c.C138T	p.H46H	exonic	ENSG00000112175.8	.	synonymous SNV	ENSG00000112175.8:ENST00000370830.4:exon1:c.C138T:p.H46H	6p12.1	C3N-00516	8.245e-06	0	0	0	0	1.499e-05	0	0	rs773535817	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100895669;OCCURENCE=1(central_nervous_system)	BMP5	418	0	713	80	0.100882723833544	TRUE	NA
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152325961	152325961	+	G	G	A	Silent	SNP	ENST00000367255.10	exon80	c.C15435T	p.H5145H	exonic	ENSG00000131018.24	.	synonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon80:c.C15435T:p.H5145H	6q25.2	C3N-00516	2.481e-05	0	0	0	0	0	0	0.0002	rs747172162	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SYNE1	220	0	557	32	0.0543293718166384	TRUE	NA
ENSG00000149091.15	.	BCM	GRCh38.p13	chr11	46379017	46379017	+	C	C	T	Silent	SNP	ENST00000456247.6	exon28	c.C2442T	p.G814G	exonic	ENSG00000149091.15	.	synonymous SNV	ENSG00000149091.15:ENST00000456247.6:exon28:c.C2442T:p.G814G	11p11.2	C3N-00516	2.271e-05	0.0003	0	0	0	0	0	0	rs148565335	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58988068;OCCURENCE=1(oesophagus)	DGKZ	58	0	109	16	0.128	TRUE	TRUE
ENSG00000111344.11	.	BCM	GRCh38.p13	chr12	113115744	113115744	+	C	C	T	Silent	SNP	ENST00000261729.9	exon11	c.G894A	p.L298L	exonic	ENSG00000111344.11	.	synonymous SNV	ENSG00000111344.11:ENST00000261729.9:exon11:c.G894A:p.L298L	12q24.13	C3N-00516	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RASAL1	280	0	405	23	0.0537383177570093	TRUE	NA
ENSG00000092529.25	.	BCM	GRCh38.p13	chr15	42394303	42394303	+	G	G	A	Silent	SNP	ENST00000397163.8	exon8	c.G1077A	p.P359P	exonic	ENSG00000092529.25	.	synonymous SNV	ENSG00000092529.25:ENST00000397163.8:exon8:c.G1077A:p.P359P	15q15.1	C3N-00516	0.0001	0.0003	0	0	0	0.0002	0	0	rs759384108	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100532508;OCCURENCE=1(stomach)	CAPN3	323	0	513	142	0.216793893129771	TRUE	NA
ENSG00000077235.18	.	BCM	GRCh38.p13	chr16	27506073	27506073	+	C	C	T	Silent	SNP	ENST00000356183.9	exon10	c.G1596A	p.P532P	exonic	ENSG00000077235.18	.	synonymous SNV	ENSG00000077235.18:ENST00000356183.9:exon10:c.G1596A:p.P532P	16p12.1	C3N-00516	1.65e-05	0	0	0	0	3.001e-05	0	0	rs781464590	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62239574;OCCURENCE=2(large_intestine)	GTF3C1	184	0	312	46	0.128491620111732	TRUE	TRUE
ENSG00000105392.16	.	BCM	GRCh38.p13	chr19	47839658	47839658	+	G	G	A	Silent	SNP	ENST00000221996.12	exon4	c.G591A	p.P197P	exonic	ENSG00000105392.16	.	synonymous SNV	ENSG00000105392.16:ENST00000221996.12:exon4:c.G591A:p.P197P	19q13.33	C3N-00516	0.0002	0	0	0	0	3.009e-05	0	0.0012	rs769009205	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55758637;OCCURENCE=2(central_nervous_system)	CRX	199	0	304	16	0.05	TRUE	TRUE
ENSG00000101193.8	.	BCM	GRCh38.p13	chr20	62943033	62943033	+	C	C	T	Silent	SNP	ENST00000266069.5	exon3	c.C165T	p.I55I	exonic	ENSG00000101193.8	.	synonymous SNV	ENSG00000101193.8:ENST00000266069.5:exon3:c.C165T:p.I55I	20q13.33	C3N-00516	.	.	.	.	.	.	.	.	rs965129217	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GID8	167	0	245	66	0.212218649517685	TRUE	NA
ENSG00000168405.17	.	BCM	GRCh38.p13	chr6	25091957	25091957	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000168405.17	.	.	.	6p22.3	C3N-00516	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CMAHP	78	0	219	17	0.0720338983050847	TRUE	NA
ENSG00000286759.1	.	BCM	GRCh38.p13	chr16	81154006	81154006	+	C	C	T	3'Flank	SNP	NA	NA	NA	NA	downstream	ENSG00000286759.1	dist=30	.	.	16q23.2	C3N-00516	0.0002	0	0	0.0012	0	0.0003	0	0	rs778461537	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC092718.9	146	0	297	18	0.0571428571428571	TRUE	NA
ENSG00000243156.9	.	BCM	GRCh38.p13	chr22	17884300	17884300	+	-	NA	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000243156.9	.	.	.	22q11.21	C3N-00516	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MICAL3	NA	NA	NA	NA	NA	NA	NA
ENSG00000118004.18	.	BCM	GRCh38.p13	chr2	3644057	3644057	+	A	A	G	Missense_Mutation	SNP	ENST00000349077.9	exon7	c.A755G	p.N252S	exonic	ENSG00000118004.18	.	nonsynonymous SNV	ENSG00000118004.18:ENST00000349077.9:exon7:c.A755G:p.N252S	2p25.3	C3L-02610	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	D	D	M	T	D	0.627	T	T	D	0.355	0.880	0.753	1.069	T	T	T	T	D	D	3.045	23.500	0.998	D	D	0.522	5.214	0.529	5.430	1.000	0.554	0.624	0.602	0.613	.	5.090	5.090	5.594	1.278	0.691	1.000	1.000	0.999	946	C-type_lectin-like;C-type_lectin,_conserved_site;Collectin,_C-type_lectin-like_domain	.	.	ID=COSV99363298;OCCURENCE=1(lung)	COLEC11	554	0	939	90	0.0874635568513119	TRUE	TRUE
ENSG00000134115.13	.	BCM	GRCh38.p13	chr3	1383173	1383173	+	G	G	T	Missense_Mutation	SNP	ENST00000446702.7	exon18	c.G2398T	p.D800Y	exonic	ENSG00000134115.13	.	nonsynonymous SNV	ENSG00000134115.13:ENST00000446702.7:exon18:c.G2398T:p.D800Y	3p26.3	C3L-02610	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.689	T	T	D	0.395	0.354	0.874	0.019	T	D	D	T	D	D	4.118	27.900	0.995	D	D	1.027	14.795	0.992	18.378	1.000	0.487	0.574	0.547	0.564	.	6.080	6.080	9.355	1.176	0.676	1.000	1.000	0.948	938	Fibronectin_type_III	.	.	ID=COSV63192865;OCCURENCE=1(lung)	CNTN6	128	0	219	23	0.0950413223140496	TRUE	TRUE
ENSG00000114353.17	.	BCM	GRCh38.p13	chr3	50257619	50257619	+	G	G	T	Missense_Mutation	SNP	ENST00000313601.11	exon8	c.G997T	p.V333L	exonic	ENSG00000114353.17	.	nonsynonymous SNV	ENSG00000114353.17:ENST00000313601.11:exon8:c.G997T:p.V333L	3p21.31	C3L-02610	.	.	.	.	.	.	.	.	.	15.20	D	T	P	P	D	D	L	D	N	0.760	D	D	D	0.832	0.667	0.973	2.233	D	D	D	D	D	D	3.935	26.600	0.997	D	D	0.564	5.571	0.585	6.043	1.000	0.722	0.702	0.702	0.735	.	4.500	4.500	8.081	1.161	0.676	1.000	1.000	0.997	3	.	.	.	.	GNAI2	81	0	130	14	0.0972222222222222	TRUE	TRUE
ENSG00000109265.14	.	BCM	GRCh38.p13	chr4	56314154	56314154	+	G	G	A	Missense_Mutation	SNP	ENST00000264229.11	exon8	c.G652A	p.E218K	exonic	ENSG00000109265.14	.	nonsynonymous SNV	ENSG00000109265.14:ENST00000264229.11:exon8:c.G652A:p.E218K	4q12	C3L-02610	.	.	.	.	.	.	.	.	.	3.19	T	T	P	B	.	N	L	T	N	0.305	T	T	T	0.031	0.136	0.188	0.857	T	T	T	T	D	D	2.331	21.700	0.995	D	N	0.012	2.553	-0.024	2.279	1.000	0.706	0.588	0.710	0.655	.	4.540	2.710	4.951	0.119	0.590	0.999	0.061	0.806	283	.	.	.	.	CRACD	336	0	496	59	0.106306306306306	TRUE	TRUE
ENSG00000112769.20	.	BCM	GRCh38.p13	chr6	112114687	112114687	+	C	C	A	Missense_Mutation	SNP	ENST00000230538.12	exon37	c.G5182T	p.D1728Y	exonic	ENSG00000112769.20	.	nonsynonymous SNV	ENSG00000112769.20:ENST00000230538.12:exon37:c.G5182T:p.D1728Y	6q21	C3L-02610	.	.	.	.	.	.	.	.	.	15.17	D	D	.	.	D	D	.	D	D	0.751	D	D	D	0.729	0.856	0.952	0.632	T	T	D	D	D	D	4.159	28.300	0.996	D	D	0.901	11.068	0.870	12.544	1.000	0.672	0.590	0.574	0.711	.	6.060	6.060	5.004	1.026	0.599	1.000	1.000	0.999	751	Laminin_G_domain	.	.	.	LAMA4	383	0	539	68	0.112026359143328	TRUE	TRUE
ENSG00000146411.6	.	BCM	GRCh38.p13	chr6	134002127	134002127	+	G	G	A	Missense_Mutation	SNP	ENST00000275230.6	exon4	c.C1570T	p.L524F	exonic	ENSG00000146411.6	.	nonsynonymous SNV	ENSG00000146411.6:ENST00000275230.6:exon4:c.C1570T:p.L524F	6q23.2	C3L-02610	1.65e-05	0	0	0	0	2.999e-05	0	0	rs138921989	3.20	T	T	B	B	N	N	L	T	N	0.411	T	T	D	0.219	.	0.587	0.545	T	T	T	T	D	T	2.886	23.200	0.996	D	N	-0.469	1.238	-0.313	1.538	0.999	0.615	0.590	0.659	0.580	.	5.780	3.980	3.843	0.213	-0.148	0.954	0.950	0.875	873	Major_facilitator_superfamily_domain	.	.	.	SLC2A12	247	0	257	16	0.0586080586080586	TRUE	NA
ENSG00000127989.14	.	BCM	GRCh38.p13	chr7	91874169	91874169	+	C	C	A	Missense_Mutation	SNP	ENST00000351870.8	exon3	c.G625T	p.D209Y	exonic	ENSG00000127989.14	.	nonsynonymous SNV	ENSG00000127989.14:ENST00000351870.8:exon3:c.G625T:p.D209Y	7q21.2	C3L-02610	.	.	.	.	.	.	.	.	.	8.19	D	D	D	P	N	D	.	T	D	0.373	T	T	T	0.106	0.348	0.325	0.046	T	T	T	T	D	D	2.592	22.600	0.992	D	N	-0.125	2.097	-0.203	1.779	0.021	0.707	0.725	0.659	0.592	.	4.880	0.969	1.156	-0.214	-0.242	0.785	0.955	0.976	145	.	.	.	.	MTERF1	235	0	260	60	0.1875	TRUE	TRUE
ENSG00000169876.14	.	BCM	GRCh38.p13	chr7	101032351	101032351	+	C	C	G	Missense_Mutation	SNP	ENST00000306151.9	exon3	c.C935G	p.A312G	exonic	ENSG00000169876.14	.	nonsynonymous SNV	ENSG00000169876.14:ENST00000306151.9:exon3:c.C935G:p.A312G	7q22.1	C3L-02610	.	.	.	.	.	.	.	.	.	1.18	D	.	P	B	.	N	L	T	N	0.029	T	T	T	0.021	0.177	0.040	.	T	T	T	T	T	T	-0.434	0.164	0.461	N	N	-1.143	0.270	-1.280	0.222	0.000	0.497	0.590	0.590	0.542	.	1.280	-0.987	-1.205	-1.183	-0.438	0.000	0.000	0.000	830	.	.	.	.	MUC17	156	0	209	16	0.0711111111111111	TRUE	TRUE
ENSG00000171115.4	.	BCM	GRCh38.p13	chr7	150477308	150477308	+	G	G	A	Missense_Mutation	SNP	ENST00000307271.4	exon5	c.G1526A	p.R509Q	exonic	ENSG00000171115.4	.	nonsynonymous SNV	ENSG00000171115.4:ENST00000307271.4:exon5:c.G1526A:p.R509Q	7q36.1	C3L-02610	8.238e-06	0	0	0	0	0	0	6.056e-05	rs749652932	0.20	T	T	B	B	N	N	N	T	N	0.040	T	T	T	0.028	0.466	0.095	0.166	T	T	T	T	T	T	-1.037	0.006	0.568	N	N	-2.031	0.008	-2.016	0.013	1.000	0.707	0.725	0.575	0.714	.	4.110	-6.520	-2.630	-0.689	-0.942	0.000	0.002	0.002	946	AIG1-type_guanine_nucleotide-binding_(G)_domain	.	.	ID=COSV56230970;OCCURENCE=1(kidney)	GIMAP8	136	1	187	33	0.15	TRUE	TRUE
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	4031967	4031967	+	A	A	T	Missense_Mutation	SNP	ENST00000635120.2	exon4	c.T548A	p.L183Q	exonic	ENSG00000183117.19	.	nonsynonymous SNV	ENSG00000183117.19:ENST00000635120.2:exon4:c.T548A:p.L183Q	8p23.2	C3L-02610	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	U	D	M	T	D	0.972	D	T	D	0.658	0.681	0.743	.	T	T	D	D	D	D	3.847	26.100	0.995	D	D	0.705	7.189	0.625	6.550	0.998	0.554	0.574	0.602	0.564	.	5.520	5.520	9.011	1.307	0.756	1.000	0.894	0.257	983	Sushi/SCR/CCP_domain	.	.	.	CSMD1	182	0	268	33	0.109634551495017	TRUE	NA
ENSG00000104228.13	.	BCM	GRCh38.p13	chr8	27289170	27289170	+	A	A	G	Missense_Mutation	SNP	ENST00000305364.9	exon5	c.T896C	p.V299A	exonic	ENSG00000104228.13	.	nonsynonymous SNV	ENSG00000104228.13:ENST00000305364.9:exon5:c.T896C:p.V299A	8p21.2	C3L-02610	.	.	.	.	.	.	.	.	.	7.20	T	D	P	B	N	D	M	T	D	0.401	T	T	D	0.276	0.669	0.728	0.559	T	T	T	T	D	T	2.471	22.300	0.979	D	N	-0.070	2.272	-0.060	2.165	1.000	0.732	0.725	0.744	0.714	.	5.950	5.950	5.404	1.312	0.756	0.644	0.104	0.521	626	0.000	.	.	.	TRIM35	99	0	186	23	0.110047846889952	TRUE	TRUE
ENSG00000150054.18	.	BCM	GRCh38.p13	chr10	28131585	28131585	+	C	C	T	Missense_Mutation	SNP	ENST00000337532.9	exon7	c.G422A	p.R141H	exonic	ENSG00000150054.18	.	nonsynonymous SNV	ENSG00000150054.18:ENST00000337532.9:exon7:c.G422A:p.R141H	10p12.1	C3L-02610	4.953e-05	9.645e-05	0	0	0	1.502e-05	0	0.0002	rs200656300	9.20	T	T	D	D	D	D	M	T	N	0.939	T	T	T	0.299	.	0.705	0.789	T	T	T	D	T	D	4.065	27.500	0.999	D	D	0.810	8.969	0.797	10.047	1.000	0.615	0.574	0.659	0.632	.	5.740	5.740	7.776	1.023	0.599	1.000	0.986	0.991	719	PDZ_domain	.	.	ID=COSV61730709;OCCURENCE=1(adrenal_gland),2(central_nervous_system),1(haematopoietic_and_lymphoid_tissue),1(prostate),1(endometrium)	MPP7	129	0	183	26	0.124401913875598	TRUE	TRUE
ENSG00000171798.18	.	BCM	GRCh38.p13	chr10	133198691	133198691	+	C	C	A	Missense_Mutation	SNP	ENST00000304613.8	exon14	c.C2183A	p.T728K	exonic	ENSG00000171798.18	.	nonsynonymous SNV	ENSG00000171798.18:ENST00000304613.8:exon14:c.C2183A:p.T728K	10q26.3	C3L-02610	.	.	.	.	.	.	.	.	.	1.19	D	T	P	B	N	N	.	T	N	0.125	T	T	T	0.020	0.271	0.085	0.243	T	T	T	T	T	T	0.261	3.828	0.475	N	N	-0.669	0.865	-0.810	0.743	0.027	0.646	0.547	0.645	0.563	.	4.000	2.050	-3.607	0.072	0.531	0.000	0.000	0.001	994	.	.	.	ID=COSV58831384;OCCURENCE=2(thyroid)	KNDC1	106	0	255	16	0.0590405904059041	TRUE	TRUE
ENSG00000188070.9	.	BCM	GRCh38.p13	chr11	63764296	63764296	+	C	C	T	Missense_Mutation	SNP	ENST00000433688.2	exon4	c.G1327A	p.G443R	exonic	ENSG00000188070.9	.	nonsynonymous SNV	ENSG00000188070.9:ENST00000433688.2:exon4:c.G1327A:p.G443R	11q13.1	C3L-02610	.	.	.	.	.	.	.	.	.	7.9	.	D	D	D	.	.	M	.	.	0.755	.	.	.	.	.	0.140	.	.	T	D	D	.	T	3.908	26.400	0.979	D	.	.	.	.	.	1.000	0.116	0.097	0.050	0.196	0.955	4.250	4.250	3.159	0.953	0.506	1.000	0.991	0.953	561	Zinc_finger_C2H2-type	.	.	.	C11orf95	81	0	242	23	0.0867924528301887	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02610	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	281	0	309	102	0.248175182481752	TRUE	TRUE
ENSG00000165966.16	.	BCM	GRCh38.p13	chr12	41573831	41573831	+	G	G	A	Missense_Mutation	SNP	ENST00000402685.7	exon10	c.G3052A	p.A1018T	exonic	ENSG00000165966.16	.	nonsynonymous SNV	ENSG00000165966.16:ENST00000402685.7:exon10:c.G3052A:p.A1018T	12q12	C3L-02610	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	N	T	N	0.171	T	T	T	0.192	0.299	0.614	0.458	T	T	T	T	D	T	1.665	16.800	0.275	D	D	-0.499	1.179	-0.253	1.663	0.144	0.554	0.574	0.602	0.564	.	5.000	4.100	3.297	1.176	0.676	1.000	1.000	0.982	789	.	.	.	.	PDZRN4	50	0	60	14	0.189189189189189	TRUE	TRUE
ENSG00000083642.19	.	BCM	GRCh38.p13	chr13	32770679	32770679	+	A	A	C	Missense_Mutation	SNP	ENST00000315596.15	exon33	c.A4090C	p.I1364L	exonic	ENSG00000083642.19	.	nonsynonymous SNV	ENSG00000083642.19:ENST00000315596.15:exon33:c.A4090C:p.I1364L	13q13.1	C3L-02610	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	N	.	N	0.279	T	T	T	0.048	0.151	0.043	0.084	T	T	T	T	T	T	1.444	15.370	0.911	D	N	-0.683	0.841	-0.433	1.314	0.222	0.707	0.725	0.725	0.714	.	6.070	3.350	1.759	0.240	-0.274	1.000	1.000	0.990	670	.	.	.	.	PDS5B	200	1	255	31	0.108391608391608	TRUE	TRUE
ENSG00000133083.14	.	BCM	GRCh38.p13	chr13	36126004	36126004	+	C	C	T	Missense_Mutation	SNP	ENST00000360631.7	exon2	c.G134A	p.R45H	exonic	ENSG00000133083.14	.	nonsynonymous SNV	ENSG00000133083.14:ENST00000360631.7:exon2:c.G134A:p.R45H	13q13.3	C3L-02610	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	N	0.735	D	D	D	0.334	0.448	0.864	1.473	D	T	D	D	D	D	4.153	28.200	0.999	D	D	0.860	10.067	0.850	11.766	1.000	0.713	0.574	0.609	0.586	.	5.670	5.670	7.730	1.026	0.599	1.000	0.997	0.996	765	.	.	.	.	DCLK1	274	1	428	46	0.0970464135021097	TRUE	TRUE
ENSG00000133110.15	.	BCM	GRCh38.p13	chr13	37569789	37569789	+	C	C	T	Missense_Mutation	SNP	ENST00000379747.9	exon20	c.G2302A	p.G768R	exonic	ENSG00000133110.15	.	nonsynonymous SNV	ENSG00000133110.15:ENST00000379747.9:exon20:c.G2302A:p.G768R	13q13.3	C3L-02610	.	.	.	.	.	.	.	.	.	11.20	D	D	P	P	N	D	L	D	N	0.510	D	D	D	0.414	0.322	0.884	0.414	T	T	D	T	D	D	3.586	25.000	0.996	D	N	0.083	2.820	0.131	2.863	0.811	0.638	0.574	0.574	0.668	.	5.360	4.500	1.860	1.026	0.599	0.994	0.861	0.883	503	.	.	.	.	POSTN	215	0	182	17	0.085427135678392	TRUE	TRUE
ENSG00000197616.12	.	BCM	GRCh38.p13	chr14	23402464	23402464	+	C	C	A	Missense_Mutation	SNP	ENST00000405093.8	exon12	c.G1141T	p.D381Y	exonic	ENSG00000197616.12	.	nonsynonymous SNV	ENSG00000197616.12:ENST00000405093.8:exon12:c.G1141T:p.D381Y	14q11.2	C3L-02610	.	.	.	.	.	.	.	.	.	10.19	T	T	P	P	.	D	L	D	N	0.567	D	D	D	0.576	0.448	0.953	0.974	T	D	T	T	D	D	5.171	33	0.983	D	D	0.234	3.459	0.176	3.070	1.000	0.497	0.590	0.578	0.613	.	3.760	3.760	4.794	1.012	0.533	1.000	0.640	0.039	373	Myosin_head,_motor_domain	.	.	.	MYH6	154	0	278	31	0.100323624595469	TRUE	TRUE
ENSG00000198732.11	.	BCM	GRCh38.p13	chr14	69952250	69952250	+	G	G	A	Missense_Mutation	SNP	ENST00000381280.4	exon2	c.G212A	p.R71Q	exonic	ENSG00000198732.11	.	nonsynonymous SNV	ENSG00000198732.11:ENST00000381280.4:exon2:c.G212A:p.R71Q	14q24.2	C3L-02610	8.237e-06	9.61e-05	0	0	0	0	0	0	rs376548937	11.20	D	D	D	D	D	D	L	T	D	0.173	T	T	T	0.215	.	0.722	0.803	T	T	T	T	D	D	3.860	26.100	0.999	D	D	0.574	5.666	0.546	5.606	1.000	0.638	0.610	0.653	0.564	.	5.440	4.550	4.444	1.176	0.676	1.000	1.000	0.992	700	Kazal_domain	.	.	.	SMOC1	205	0	299	47	0.135838150289017	TRUE	NA
ENSG00000184986.11	.	BCM	GRCh38.p13	chr14	105528845	105528845	+	C	C	T	Missense_Mutation	SNP	ENST00000392519.7	exon2	c.C11T	p.P4L	exonic	ENSG00000184986.11	.	nonsynonymous SNV	ENSG00000184986.11:ENST00000392519.7:exon2:c.C11T:p.P4L	14q32.33	C3L-02610	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	U	D	N	.	D	0.388	T	T	D	0.164	0.235	0.314	1.273	D	T	T	T	D	D	3.460	24.600	0.998	D	D	0.452	4.682	0.424	4.533	1.000	0.583	0.607	0.615	0.568	.	3.770	3.770	4.475	1.010	0.527	1.000	0.998	0.996	952	.	.	.	.	TMEM121	87	0	151	27	0.151685393258427	TRUE	TRUE
ENSG00000179455.9	.	BCM	GRCh38.p13	chr15	23566425	23566425	+	C	C	T	Missense_Mutation	SNP	ENST00000314520.6	exon1	c.C643T	p.R215C	exonic	ENSG00000179455.9	.	nonsynonymous SNV	ENSG00000179455.9:ENST00000314520.6:exon1:c.C643T:p.R215C	15q11.2	C3L-02610	8.279e-06	0	0	0	0	1.503e-05	0	0	rs779114986	10.20	D	D	D	P	D	D	M	T	D	0.313	T	T	T	0.208	0.529	0.753	0.097	T	T	T	T	D	T	3.999	27.000	0.999	D	D	0.438	4.586	0.380	4.220	1.000	0.487	0.514	0.574	0.651	.	4.070	4.070	3.643	0.941	0.599	1.000	0.749	0.515	994	.	.	.	ID=COSV58809720;OCCURENCE=1(urinary_tract)	MKRN3	220	0	402	34	0.0779816513761468	TRUE	TRUE
ENSG00000159433.12	.	BCM	GRCh38.p13	chr15	42694658	42694658	+	C	C	A	Missense_Mutation	SNP	ENST00000290607.12	exon24	c.C12895A	p.L4299I	exonic	ENSG00000159433.12	.	nonsynonymous SNV	ENSG00000159433.12:ENST00000290607.12:exon24:c.C12895A:p.L4299I	15q15.2	C3L-02610	.	.	.	.	.	.	.	.	.	4.16	D	.	.	.	.	N	M	T	N	0.240	T	T	D	0.050	.	0.067	.	T	T	T	T	D	T	1.322	14.550	0.989	N	N	-0.332	1.536	-0.433	1.314	0.297	0.732	0.744	0.659	0.684	.	5.810	2.620	0.037	1.026	0.599	0.000	0.715	0.475	91	.	.	.	.	STARD9	258	0	373	42	0.101204819277108	TRUE	TRUE
ENSG00000103522.16	.	BCM	GRCh38.p13	chr16	27443041	27443041	+	C	C	A	Missense_Mutation	SNP	ENST00000337929.8	exon5	c.C432A	p.D144E	exonic	ENSG00000103522.16	.	nonsynonymous SNV	ENSG00000103522.16:ENST00000337929.8:exon5:c.C432A:p.D144E	16p12.1	C3L-02610	.	.	.	.	.	.	.	.	rs949248876	1.20	T	T	B	B	N	N	N	T	N	0.097	T	T	D	0.019	.	0.457	0.264	T	T	T	T	T	T	-0.519	0.108	0.689	N	N	-1.636	0.048	-1.639	0.065	0.995	0.672	0.702	0.602	0.613	.	3.630	-2.400	-0.198	-0.434	-0.316	0.005	0.004	0.013	889	Fibronectin_type_III	.	.	.	IL21R	103	0	173	18	0.0942408376963351	TRUE	NA
ENSG00000169181.13	.	BCM	GRCh38.p13	chr16	28063179	28063179	+	-	NA	G	Frame_Shift_Ins	NA	ENST00000447459.7	exon1	c.245dupC	p.G83Wfs*36	exonic	ENSG00000169181.13	.	frameshift insertion	ENSG00000169181.13:ENST00000447459.7:exon1:c.245dupC:p.G83Wfs*36	16p12.1	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GSG1L	NA	NA	NA	NA	NA	NA	NA
ENSG00000167513.9	.	BCM	GRCh38.p13	chr16	88804841	88804841	+	C	C	T	Missense_Mutation	SNP	ENST00000301019.9	exon3	c.C431T	p.A144V	exonic	ENSG00000167513.9	.	nonsynonymous SNV	ENSG00000167513.9:ENST00000301019.9:exon3:c.C431T:p.A144V	16q24.3	C3L-02610	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.046	T	T	T	0.030	0.204	0.714	0.013	T	T	T	T	T	T	0.611	7.622	0.979	N	N	-0.862	0.569	-0.898	0.623	1.000	0.767	0.672	0.672	0.555	.	4.260	2.170	0.747	-0.294	-0.277	0.002	0.007	0.004	793	.	.	.	.	CDT1	275	1	497	86	0.147512864493997	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675070	7675070	+	C	C	G	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G542C	p.R181P	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G542C:p.R181P	17p13.1	C3L-02610	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.890	D	D	D	0.894	0.944	0.982	1.991	T	D	D	D	D	D	3.696	25.400	0.997	D	D	0.485	4.921	0.396	4.334	0.977	0.722	0.698	0.698	0.735	.	5.260	4.280	0.789	1.026	0.599	0.107	0.987	0.535	434	p53,_DNA-binding_domain	.	.	ID=COSV52676870;OCCURENCE=3(breast),1(liver),3(large_intestine),2(ovary),1(haematopoietic_and_lymphoid_tissue),3(urinary_tract),10(lung),2(upper_aerodigestive_tract)	TP53	334	0	524	85	0.139573070607553	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11611672	11611672	+	T	T	A	Missense_Mutation	SNP	ENST00000262442.9	exon4	c.T796A	p.Y266N	exonic	ENSG00000007174.18	.	nonsynonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon4:c.T796A:p.Y266N	17p12	C3L-02610	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	N	D	M	T	D	0.503	T	T	D	0.139	0.696	0.646	0.147	T	T	T	T	D	D	1.551	16.070	0.882	D	N	-0.249	1.744	-0.180	1.834	0.000	0.487	0.574	0.547	0.564	.	5.690	3.490	1.133	1.120	0.644	1.000	0.998	0.382	670	Dynein_heavy_chain,_domain-1	.	.	.	DNAH9	133	0	158	20	0.112359550561798	TRUE	TRUE
ENSG00000108375.12	.	BCM	GRCh38.p13	chr17	58362570	58362570	+	G	G	A	Missense_Mutation	SNP	ENST00000584437.5	exon5	c.C661T	p.R221W	exonic	ENSG00000108375.12;ENSG00000285897.1	.	nonsynonymous SNV	ENSG00000108375.12:ENST00000584437.5:exon5:c.C661T:p.R221W,ENSG00000285897.1:ENST00000648873.1:exon5:c.C661T:p.R221W	17q22	C3L-02610	4.223e-05	0	0	0	0.0002	1.528e-05	0	0.0002	rs748533737	12.20	D	D	D	D	D	D	M	T	D	0.597	T	T	T	0.209	0.544	0.468	1.084	T	T	T	T	D	D	3.556	24.900	0.999	D	D	0.019	2.581	0.019	2.426	1.000	0.646	0.546	0.645	0.542	.	5.430	0.192	1.423	-0.198	-0.182	1.000	0.997	0.943	308	.	.	.	ID=COSV68458461;OCCURENCE=1(large_intestine)	RNF43	70	0	142	27	0.159763313609467	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51047143	51047143	+	G	G	T	Nonsense_Mutation	SNP	ENST00000342988.8	exon2	c.G97T	p.E33X	exonic	ENSG00000141646.14	.	stopgain	ENSG00000141646.14:ENST00000342988.8:exon2:c.G97T:p.E33X	18q21.2	C3L-02610	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.929	.	.	.	.	.	.	.	.	.	D	D	.	.	6.813	36	0.998	D	N	1.293	38.414	1.165	37.551	1.000	0.706	0.725	0.710	0.613	.	5.860	5.860	10.003	1.161	0.676	1.000	1.000	1.000	672	MAD_homology_1,_Dwarfin-type;MAD_homology,_MH1	.	.	ID=COSV61695955;OCCURENCE=1(large_intestine)	SMAD4	406	0	380	86	0.184549356223176	TRUE	TRUE
ENSG00000167554.15	.	BCM	GRCh38.p13	chr19	52365857	52365857	+	C	C	T	Missense_Mutation	SNP	ENST00000403906.8	exon6	c.C479T	p.S160L	exonic	ENSG00000167554.15	.	nonsynonymous SNV	ENSG00000167554.15:ENST00000403906.8:exon6:c.C479T:p.S160L	19q13.41	C3L-02610	3.308e-05	0	0	0.0005	0	0	0	0	rs768546961	1.19	T	T	B	B	.	N	L	T	D	0.159	T	T	T	0.007	0.345	0.132	0.161	T	T	T	T	T	T	0.009	1.394	0.760	N	N	-1.452	0.097	-1.567	0.085	0.000	0.554	0.588	0.602	0.568	.	1.110	-1.380	-1.622	-0.939	-1.203	0.000	0.013	0.011	988	.	.	.	.	ZNF610	178	0	188	32	0.145454545454545	TRUE	NA
ENSG00000099889.14	.	BCM	GRCh38.p13	chr22	19972408	19972408	+	C	C	T	Missense_Mutation	SNP	ENST00000263207.8	exon17	c.G2645A	p.G882D	exonic	ENSG00000099889.14	.	nonsynonymous SNV	ENSG00000099889.14:ENST00000263207.8:exon17:c.G2645A:p.G882D	22q11.21	C3L-02610	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.240	T	T	D	0.072	0.153	0.349	0.155	T	T	T	T	T	T	0.485	6.346	0.778	N	N	-1.178	0.243	-1.193	0.289	1.000	0.672	0.551	0.702	0.711	.	4.380	2.280	0.597	-0.240	-0.825	0.000	0.007	0.001	738	.	.	.	.	ARVCF	193	0	326	23	0.0659025787965616	TRUE	TRUE
ENSG00000104499.7	.	BCM	GRCh38.p13	chr8	142840512	142840512	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000104499.7	ENST00000220940.2:exon2:c.73+2T>C	.	.	8q24.3	C3L-02610	.	.	.	.	.	.	.	.	.	1.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	3.656	25.200	0.943	N	.	0.662	6.618	0.387	4.265	0.001	0.066	0.061	0.078	0.063	0.205	2.970	2.970	1.566	0.905	0.660	0.984	0.207	0.142	988	.	.	.	.	GML	137	0	296	26	0.0807453416149068	TRUE	TRUE
ENSG00000117148.8	.	BCM	GRCh38.p13	chr1	17823335	17823335	+	G	G	A	Silent	SNP	ENST00000375406.2	exon2	c.G327A	p.A109A	exonic	ENSG00000117148.8	.	synonymous SNV	ENSG00000117148.8:ENST00000375406.2:exon2:c.G327A:p.A109A	1p36.13	C3L-02610	7.588e-05	0	8.676e-05	0	0	6.134e-05	0	0.0003	rs765307312	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64861016;OCCURENCE=2(endometrium)	ACTL8	114	1	165	17	0.0934065934065934	TRUE	TRUE
ENSG00000186409.18	.	BCM	GRCh38.p13	chr1	42653899	42653899	+	T	T	C	Silent	SNP	ENST00000342022.8	exon16	c.T2223C	p.S741S	exonic	ENSG00000186409.18	.	synonymous SNV	ENSG00000186409.18:ENST00000342022.8:exon16:c.T2223C:p.S741S	1p34.2	C3L-02610	8.241e-06	0	0	0	0	1.499e-05	0	0	rs765865782	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC30	341	0	347	37	0.0963541666666667	TRUE	NA
ENSG00000121440.15	.	BCM	GRCh38.p13	chr3	73624112	73624112	+	G	G	A	Silent	SNP	ENST00000263666.9	exon1	c.C714T	p.P238P	exonic	ENSG00000121440.15	.	synonymous SNV	ENSG00000121440.15:ENST00000263666.9:exon1:c.C714T:p.P238P	3p13	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDZRN3	85	0	201	26	0.114537444933921	TRUE	NA
ENSG00000163530.4	.	BCM	GRCh38.p13	chr3	109312624	109312624	+	G	G	A	Silent	SNP	ENST00000478945.1	exon3	c.C102T	p.D34D	exonic	ENSG00000163530.4	.	synonymous SNV	ENSG00000163530.4:ENST00000478945.1:exon3:c.C102T:p.D34D	3q13.13	C3L-02610	5.766e-05	9.61e-05	0.0002	0	0	1.499e-05	0	0.0002	rs572153453	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV72117901;OCCURENCE=2(breast),5(large_intestine),1(central_nervous_system),1(skin),2(lung)	DPPA2	128	0	152	10	0.0617283950617284	TRUE	NA
ENSG00000215612.8	.	BCM	GRCh38.p13	chr4	8867846	8867846	+	G	G	A	Silent	SNP	ENST00000400677.5	exon2	c.C894T	p.P298P	exonic	ENSG00000215612.8	.	synonymous SNV	ENSG00000215612.8:ENST00000400677.5:exon2:c.C894T:p.P298P	4p16.1	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HMX1	26	0	39	13	0.25	TRUE	TRUE
ENSG00000172869.14	.	BCM	GRCh38.p13	chr5	119221024	119221024	+	C	C	T	Silent	SNP	ENST00000311085.8	exon36	c.C8157T	p.G2719G	exonic	ENSG00000172869.14	.	synonymous SNV	ENSG00000172869.14:ENST00000311085.8:exon36:c.C8157T:p.G2719G	5q23.1	C3L-02610	8.304e-06	0	0	0	0	0	0	6.083e-05	rs751162158	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DMXL1	191	0	219	27	0.109756097560976	TRUE	NA
ENSG00000145908.12	.	BCM	GRCh38.p13	chr5	150895985	150895985	+	G	G	A	Silent	SNP	ENST00000274599.9	exon6	c.C1254T	p.F418F	exonic	ENSG00000145908.12	.	synonymous SNV	ENSG00000145908.12:ENST00000274599.9:exon6:c.C1254T:p.F418F	5q33.1	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF300	128	1	199	24	0.10762331838565	TRUE	TRUE
ENSG00000135074.16	.	BCM	GRCh38.p13	chr5	157488325	157488325	+	C	C	T	Silent	SNP	ENST00000517905.1	exon21	c.G2490A	p.S830S	exonic	ENSG00000135074.16	.	synonymous SNV	ENSG00000135074.16:ENST00000517905.1:exon21:c.G2490A:p.S830S	5q33.3	C3L-02610	8.265e-06	0	0	0.0001	0	0	0	0	rs764968777	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57427459;OCCURENCE=1(prostate)	ADAM19	139	0	271	42	0.134185303514377	TRUE	TRUE
ENSG00000146411.6	.	BCM	GRCh38.p13	chr6	134006909	134006909	+	G	G	A	Silent	SNP	ENST00000275230.6	exon3	c.C1470T	p.I490I	exonic	ENSG00000146411.6	.	synonymous SNV	ENSG00000146411.6:ENST00000275230.6:exon3:c.C1470T:p.I490I	6q23.2	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC2A12	192	0	282	33	0.104761904761905	TRUE	TRUE
ENSG00000188763.5	.	BCM	GRCh38.p13	chr7	73434685	73434685	+	C	C	A	Silent	SNP	ENST00000344575.5	exon1	c.C678A	p.R226R	exonic	ENSG00000188763.5	.	synonymous SNV	ENSG00000188763.5:ENST00000344575.5:exon1:c.C678A:p.R226R	7q11.23	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FZD9	117	0	282	83	0.227397260273973	TRUE	TRUE
ENSG00000061337.15	.	BCM	GRCh38.p13	chr8	20252803	20252803	+	C	C	T	Silent	SNP	ENST00000381569.5	exon3	c.G1128A	p.A376A	exonic	ENSG00000061337.15	.	synonymous SNV	ENSG00000061337.15:ENST00000381569.5:exon3:c.G1128A:p.A376A	8p21.3	C3L-02610	1.866e-05	0	0	0.0001	0	0	0	0.0001	rs772680970	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56115797;OCCURENCE=1(liver)	LZTS1	8	0	36	5	0.121951219512195	TRUE	TRUE
ENSG00000160973.8	.	BCM	GRCh38.p13	chr8	144474891	144474891	+	G	G	A	Silent	SNP	ENST00000377317.5	exon3	c.C445T	p.L149L	exonic	ENSG00000160973.8	.	synonymous SNV	ENSG00000160973.8:ENST00000377317.5:exon3:c.C445T:p.L149L	8q24.3	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FOXH1	259	1	527	131	0.199088145896657	TRUE	TRUE
ENSG00000176742.2	.	BCM	GRCh38.p13	chr11	5199864	5199864	+	G	G	A	Silent	SNP	ENST00000321255.1	exon1	c.C837T	p.P279P	exonic	ENSG00000176742.2	.	synonymous SNV	ENSG00000176742.2:ENST00000321255.1:exon1:c.C837T:p.P279P	11p15.4	C3L-02610	8.247e-06	0	0	0	0	1.5e-05	0	0	rs142226521	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR51V1	186	0	244	28	0.102941176470588	TRUE	NA
ENSG00000173898.13	.	BCM	GRCh38.p13	chr11	66689853	66689853	+	G	G	A	Silent	SNP	ENST00000533211.5	exon29	c.C5901T	p.I1967I	exonic	ENSG00000173898.13	.	synonymous SNV	ENSG00000173898.13:ENST00000533211.5:exon29:c.C5901T:p.I1967I	11q13.2	C3L-02610	3.296e-05	0.0003	0	0	0	1.499e-05	0	0	rs200009167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100018167;OCCURENCE=1(stomach)	SPTBN2	450	0	731	221	0.232142857142857	TRUE	NA
ENSG00000165458.14	.	BCM	GRCh38.p13	chr11	72231608	72231608	+	C	C	T	Silent	SNP	ENST00000298229.7	exon13	c.C1608T	p.N536N	exonic	ENSG00000165458.14	.	synonymous SNV	ENSG00000165458.14:ENST00000298229.7:exon13:c.C1608T:p.N536N	11q13.4	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INPPL1	174	0	277	37	0.117834394904459	TRUE	TRUE
ENSG00000154133.15	.	BCM	GRCh38.p13	chr11	124895650	124895650	+	C	C	T	Silent	SNP	ENST00000306534.8	exon6	c.G843A	p.T281T	exonic	ENSG00000154133.15	.	synonymous SNV	ENSG00000154133.15:ENST00000306534.8:exon6:c.G843A:p.T281T	11q24.2	C3L-02610	0.0003	0.0031	8.667e-05	0	0	4.664e-05	0	0.0004	rs138055137	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ROBO4	111	0	270	24	0.0816326530612245	TRUE	NA
ENSG00000126218.12	.	BCM	GRCh38.p13	chr13	113149265	113149265	+	C	C	T	Silent	SNP	ENST00000375559.8	exon8	c.C1215T	p.A405A	exonic	ENSG00000126218.12	.	synonymous SNV	ENSG00000126218.12:ENST00000375559.8:exon8:c.C1215T:p.A405A	13q34	C3L-02610	1.662e-05	0	0	0	0	3.035e-05	0	0	rs770904651	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	F10	404	0	749	93	0.110451306413302	TRUE	NA
ENSG00000165762.3	.	BCM	GRCh38.p13	chr14	19876531	19876531	+	T	T	C	Silent	SNP	ENST00000641885.1	exon2	c.T264C	p.G88G	exonic	ENSG00000165762.3	.	synonymous SNV	ENSG00000165762.3:ENST00000641885.1:exon2:c.T264C:p.G88G	14q11.2	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR4K2	431	1	621	33	0.0504587155963303	TRUE	TRUE
ENSG00000015413.9	.	BCM	GRCh38.p13	chr16	89636305	89636305	+	C	C	T	Silent	SNP	ENST00000393092.7	exon4	c.C279T	p.D93D	exonic	ENSG00000015413.9	.	synonymous SNV	ENSG00000015413.9:ENST00000393092.7:exon4:c.C279T:p.D93D	16q24.3	C3L-02610	0.0009	0.0001	0	0.0103	0	0	0	0.0009	rs141650009	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DPEP1	267	0	524	51	0.088695652173913	TRUE	NA
ENSG00000132141.14	.	BCM	GRCh38.p13	chr17	34961277	34961277	+	A	A	G	Silent	SNP	ENST00000314144.10	exon1	c.T117C	p.G39G	exonic	ENSG00000132141.14	.	synonymous SNV	ENSG00000132141.14:ENST00000314144.10:exon1:c.T117C:p.G39G	17q12	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCT6B	58	1	141	23	0.140243902439024	TRUE	TRUE
ENSG00000125991.19	.	BCM	GRCh38.p13	chr20	35556059	35556059	+	C	C	T	Silent	SNP	ENST00000348547.6	exon9	c.C744T	p.H248H	exonic	ENSG00000125991.19	.	synonymous SNV	ENSG00000125991.19:ENST00000348547.6:exon9:c.C744T:p.H248H	20q11.22	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ERGIC3	195	0	256	31	0.10801393728223	TRUE	TRUE
ENSG00000099954.18	.	BCM	GRCh38.p13	chr22	17548614	17548614	+	G	G	A	Silent	SNP	ENST00000342247.9	exon18	c.G3387A	p.T1129T	exonic	ENSG00000099954.18	.	synonymous SNV	ENSG00000099954.18:ENST00000342247.9:exon18:c.G3387A:p.T1129T	22q11.21	C3L-02610	1.725e-05	0	0	0.0001	0	1.555e-05	0	0	rs751868810	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CECR2	259	0	406	52	0.11353711790393	TRUE	NA
ENSG00000100249.4	.	BCM	GRCh38.p13	chr22	29059009	29059009	+	C	C	T	Silent	SNP	ENST00000216071.4	exon3	c.G606A	p.T202T	exonic	ENSG00000100249.4	.	synonymous SNV	ENSG00000100249.4:ENST00000216071.4:exon3:c.G606A:p.T202T	22q12.1	C3L-02610	0.0003	0	0.0015	0.0002	0	4.495e-05	0.0011	0.0008	rs776057378	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53310737;OCCURENCE=1(endometrium)	C22orf31	286	0	389	58	0.129753914988814	TRUE	TRUE
ENSG00000116132.12	.	BCM	GRCh38.p13	chr1	170730300	170730300	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000116132.12	.	.	.	1q24.2	C3L-02610	.	.	.	.	.	.	.	.	.	12.16	D	T	D	D	.	D	.	D	N	0.863	D	D	D	0.488	0.357	0.852	.	.	.	D	T	D	T	1.996	19.230	0.979	D	D	0.684	6.900	0.696	7.676	1.000	0.554	0.588	0.624	0.621	.	5.670	5.670	4.317	1.176	0.676	1.000	1.000	1.000	725	.	.	.	.	PRRX1	256	0	334	34	0.0923913043478261	TRUE	TRUE
ENSG00000179397.18	.	BCM	GRCh38.p13	chr1	244635486	244635486	+	-	NA	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000179397.18	.	.	.	1q44	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CATSPERE	NA	NA	NA	NA	NA	NA	NA
ENSG00000175899.15	.	BCM	GRCh38.p13	chr12	9115864	9115864	+	G	G	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000175899.15	ENST00000318602.12:c.-15C>A	.	.	12p13.31	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	A2M	321	1	449	121	0.212280701754386	TRUE	NA
ENSG00000229807.12	.	BCM	GRCh38.p13	chrX	73848459	73848459	+	T	T	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000229807.12	.	.	.	Xq13.2	C3L-02610	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	XIST	92	0	93	32	0.256	TRUE	NA
ENSG00000143674.11	.	BCM	GRCh38.p13	chr1	233362125	233362125	+	C	C	T	Missense_Mutation	SNP	ENST00000366624.8	exon5	c.C1384T	p.R462W	exonic	ENSG00000143674.11	.	nonsynonymous SNV	ENSG00000143674.11:ENST00000366624.8:exon5:c.C1384T:p.R462W	1q42.2	C3N-02579	8.667e-06	0.0001	0	0	0	0	0	0	rs149651212	16.19	D	D	D	D	D	D	.	T	D	0.583	D	D	D	0.542	.	0.764	1.802	T	T	D	D	D	D	3.926	26.500	0.999	D	D	0.268	3.617	0.127	2.848	1.000	0.675	0.547	0.693	0.568	.	4.770	1.470	0.978	1.026	0.599	0.846	0.081	0.962	909	.	.	.	ID=COSV64046138;OCCURENCE=1(biliary_tract)	MAP3K21	347	0	364	181	0.332110091743119	TRUE	TRUE
ENSG00000134115.13	.	BCM	GRCh38.p13	chr3	1295661	1295661	+	G	G	A	Missense_Mutation	SNP	ENST00000446702.7	exon6	c.G515A	p.R172Q	exonic	ENSG00000134115.13	.	nonsynonymous SNV	ENSG00000134115.13:ENST00000446702.7:exon6:c.G515A:p.R172Q	3p26.3	C3N-02579	4.169e-05	9.905e-05	8.78e-05	0	0	0	0	0.0002	rs774492055	13.20	D	D	P	B	D	D	H	T	D	0.496	D	D	D	0.336	0.836	0.904	0.020	T	T	T	T	D	D	3.370	24.300	1.000	D	D	0.592	5.843	0.490	5.073	0.626	0.487	0.574	0.574	0.564	.	5.910	5.030	5.581	1.176	0.676	0.998	0.233	0.421	981	Immunoglobulin_subtype;Immunoglobulin_subtype_2;Immunoglobulin-like_domain	.	.	ID=COSV63172416;OCCURENCE=1(large_intestine),1(stomach),1(skin),1(endometrium)	CNTN6	226	0	289	67	0.188202247191011	TRUE	TRUE
ENSG00000135605.13	.	BCM	GRCh38.p13	chr4	48145561	48145561	+	G	G	A	Missense_Mutation	SNP	ENST00000381501.8	exon13	c.C1100T	p.P367L	exonic	ENSG00000135605.13	.	nonsynonymous SNV	ENSG00000135605.13:ENST00000381501.8:exon13:c.C1100T:p.P367L	4p12	C3N-02579	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	N	D	M	T	D	0.850	T	T	D	0.451	0.622	0.857	1.110	D	D	T	T	D	D	4.078	27.600	0.993	D	D	0.505	5.074	0.442	4.670	1.000	0.707	0.725	0.602	0.530	.	5.450	4.620	8.041	1.176	0.618	1.000	0.728	0.268	415	.	.	.	.	TEC	219	0	247	50	0.168350168350168	TRUE	TRUE
ENSG00000158321.18	.	BCM	GRCh38.p13	chr7	70777139	70777139	+	G	G	A	Missense_Mutation	SNP	ENST00000342771.10	exon14	c.G1969A	p.A657T	exonic	ENSG00000158321.18	.	nonsynonymous SNV	ENSG00000158321.18:ENST00000342771.10:exon14:c.G1969A:p.A657T	7q11.22	C3N-02579	1.648e-05	0	0	0	0	2.997e-05	0	0	rs750187638	17.20	D	D	D	D	D	D	M	T	D	0.875	T	T	D	0.514	.	0.602	1.170	D	D	D	D	D	D	4.370	31	0.986	D	D	0.725	7.484	0.700	7.743	1.000	0.731	0.750	0.702	0.621	.	5.530	4.640	9.476	1.176	0.676	1.000	0.999	0.997	942	.	.	.	.	AUTS2	257	0	367	63	0.146511627906977	TRUE	NA
ENSG00000146910.12	.	BCM	GRCh38.p13	chr7	155509003	155509003	+	G	G	A	Missense_Mutation	SNP	ENST00000321736.5	exon2	c.C35T	p.T12M	exonic	ENSG00000146910.12	.	nonsynonymous SNV	ENSG00000146910.12:ENST00000321736.5:exon2:c.C35T:p.T12M	7q36.3	C3N-02579	8.298e-05	0.0010	0	0	0	0	0	0	rs192432169	9.19	D	D	D	D	D	N	.	T	D	0.464	T	T	D	0.238	.	0.076	0.385	T	T	T	T	D	T	3.648	25.200	0.999	D	N	0.435	4.571	0.364	4.111	1.000	0.598	0.563	0.596	0.530	.	5.000	5.000	4.306	1.176	0.676	0.957	0.953	0.996	784	Domain_of_unknown_function_DUF3456	.	.	ID=COSV58786471;OCCURENCE=1(breast),2(large_intestine)	CNPY1	141	0	145	36	0.198895027624309	TRUE	TRUE
ENSG00000164961.16	.	BCM	GRCh38.p13	chr8	125059413	125059413	+	C	C	T	Missense_Mutation	SNP	ENST00000318410.12	exon13	c.G1651A	p.V551I	exonic	ENSG00000164961.16	.	nonsynonymous SNV	ENSG00000164961.16:ENST00000318410.12:exon13:c.G1651A:p.V551I	8q24.13	C3N-02579	1.65e-05	0	0	0	0	3.002e-05	0	0	rs374338104	3.19	T	T	P	B	N	N	.	D	N	0.195	T	T	T	0.162	.	0.508	0.221	T	T	T	T	T	D	1.023	11.910	0.762	D	N	-0.574	1.035	-0.478	1.237	0.999	0.732	0.654	0.744	0.714	.	5.670	1.750	1.529	-0.226	0.594	0.872	0.991	0.998	736	.	.	.	.	WASHC5	339	0	403	86	0.175869120654397	TRUE	NA
ENSG00000136881.11	.	BCM	GRCh38.p13	chr9	101368185	101368185	+	T	T	A	Nonsense_Mutation	SNP	ENST00000259407.6	exon3	c.A604T	p.K202X	exonic	ENSG00000136881.11	.	stopgain	ENSG00000136881.11:ENST00000259407.6:exon3:c.A604T:p.K202X	9q31.1	C3N-02579	.	.	.	.	.	.	.	.	.	2.6	.	.	.	.	N	A	.	.	.	0.728	.	.	.	.	.	.	.	.	.	D	T	.	.	3.045	23.500	0.965	N	N	-0.576	1.031	-0.992	0.498	1.000	0.554	0.574	0.618	0.564	.	4.470	-4.890	-3.965	-1.337	-0.153	0.000	0.000	0.000	916	.	.	.	.	BAAT	367	0	434	125	0.223613595706619	TRUE	TRUE
ENSG00000175518.8	.	BCM	GRCh38.p13	chr11	5515748	5515748	+	G	G	A	Missense_Mutation	SNP	ENST00000380184.2	exon1	c.C694T	p.L232F	exonic	ENSG00000175518.8	.	nonsynonymous SNV	ENSG00000175518.8:ENST00000380184.2:exon1:c.C694T:p.L232F	11p15.4	C3N-02579	8.242e-06	9.641e-05	0	0	0	0	0	0	rs748666024	3.20	T	T	B	B	N	D	M	T	N	0.188	T	T	T	0.101	0.542	0.341	0.015	T	T	T	T	T	T	1.580	16.240	0.998	D	N	-0.386	1.413	-0.324	1.516	0.925	0.554	0.588	0.602	0.621	.	5.050	3.150	3.762	1.172	0.671	1.000	0.991	0.454	697	.	.	.	.	UBQLNL	200	0	225	68	0.232081911262799	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-02579	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	235	0	226	75	0.249169435215947	TRUE	TRUE
ENSG00000187537.13	.	BCM	GRCh38.p13	chr14	19413400	19413400	+	G	G	C	Missense_Mutation	SNP	ENST00000547848.5	exon9	c.C1363G	p.P455A	exonic	ENSG00000187537.13	.	nonsynonymous SNV	ENSG00000187537.13:ENST00000547848.5:exon9:c.C1363G:p.P455A	14q11.2	C3N-02579	.	.	.	.	.	.	.	.	.	2.16	D	D	.	.	.	N	.	T	N	0.065	T	T	T	0.094	0.306	0.043	.	T	T	T	T	T	T	0.605	7.558	0.805	N	N	-1.023	0.380	-1.241	0.251	0.000	0.554	0.588	0.574	0.564	.	1.530	-1.330	-0.401	-0.066	0.318	0.000	0.001	0.009	994	.	.	.	.	POTEG	172	0	158	16	0.0919540229885057	NA	TRUE
ENSG00000009830.11	.	BCM	GRCh38.p13	chr14	77280426	77280426	+	G	G	A	Missense_Mutation	SNP	ENST00000261534.8	exon16	c.C1691T	p.T564M	exonic	ENSG00000009830.11	.	nonsynonymous SNV	ENSG00000009830.11:ENST00000261534.8:exon16:c.C1691T:p.T564M	14q24.3	C3N-02579	0.0001	9.617e-05	0.0005	0.0001	0	8.993e-05	0	6.066e-05	rs142445941	18.20	D	D	D	D	D	D	M	D	D	0.595	D	D	D	0.620	.	0.963	0.459	T	D	T	D	D	D	4.076	27.600	0.999	D	D	0.723	7.456	0.715	8.041	1.000	0.706	0.709	0.710	0.714	.	5.490	5.490	5.799	1.176	0.676	1.000	0.941	0.945	738	Protein_O-mannosyl-transferase,_C-terminal_four_TM_domain	.	.	.	POMT2	485	0	562	136	0.194842406876791	TRUE	NA
ENSG00000161992.6	.	BCM	GRCh38.p13	chr16	563925	563925	+	G	G	A	Missense_Mutation	SNP	ENST00000409413.4	exon2	c.G631A	p.V211I	exonic	ENSG00000161992.6	.	nonsynonymous SNV	ENSG00000161992.6:ENST00000409413.4:exon2:c.G631A:p.V211I	16p13.3	C3N-02579	0.0001	0	0	0.0004	0	4.958e-05	0	0.0002	rs747782968	1.19	T	T	P	B	N	N	L	T	N	0.139	T	T	T	0.038	.	0.048	0.128	.	T	T	T	T	T	0.492	6.418	0.843	D	N	0.077	2.798	0.093	2.706	0.997	0.581	0.627	0.576	0.563	.	4.530	3.500	0.993	-0.180	-0.108	0.655	0.264	0.347	783	.	.	.	.	PRR35	162	0	172	51	0.228699551569507	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673803	7673803	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.C817T	p.R273C	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.C817T:p.R273C	17p13.1	C3N-02579	8.886e-06	0	0	0	0	1.605e-05	0	0	rs121913343	19.20	D	D	D	D	D	D	M	D	D	0.973	D	D	D	0.901	0.987	0.997	0.443	T	D	D	D	D	D	4.377	31	0.999	D	D	0.483	4.906	0.319	3.829	0.520	0.722	0.702	0.725	0.735	.	4.920	3.950	5.730	1.172	0.672	1.000	0.869	0.988	432	p53,_DNA-binding_domain	.	.	ID=COSV52662066;OCCURENCE=3(salivary_gland),68(breast),4(penis),23(liver),1(peritoneum),1(genital_tract),34(oesophagus),5(adrenal_gland),5(cervix),261(large_intestine),256(central_nervous_system),11(biliary_tract),10(vulva),2(pleura),46(ovary),13(bone),1(NS),55(stomach),59(haematopoietic_and_lymphoid_tissue),2(soft_tissue),8(kidney),20(urinary_tract),30(pancreas),13(skin),43(prostate),35(lung),11(thyroid),55(upper_aerodigestive_tract),1(testis),1(eye),7(small_intestine),49(endometrium)	TP53	645	1	454	171	0.2736	TRUE	TRUE
ENSG00000132141.14	.	BCM	GRCh38.p13	chr17	34930964	34930964	+	C	C	T	Missense_Mutation	SNP	ENST00000314144.10	exon12	c.G1435A	p.V479I	exonic	ENSG00000132141.14	.	nonsynonymous SNV	ENSG00000132141.14:ENST00000314144.10:exon12:c.G1435A:p.V479I	17q12	C3N-02579	3.3e-05	0	8.691e-05	0	0	3e-05	0	6.064e-05	rs779683070	2.20	T	T	B	B	N	D	N	T	N	0.162	T	T	D	0.154	0.533	0.235	0.063	T	T	T	T	T	T	1.150	13.220	0.736	N	N	-0.838	0.602	-0.668	0.947	0.000	0.638	0.670	0.653	0.586	.	4.850	-0.070	1.588	0.204	-0.169	0.938	1.000	0.963	344	.	.	.	ID=COSV58490240;OCCURENCE=1(kidney)	CCT6B	131	0	211	33	0.135245901639344	TRUE	TRUE
ENSG00000108797.12	.	BCM	GRCh38.p13	chr17	42697706	42697708	+	GTT	GTT	-	In_Frame_Del	DEL	ENST00000264638.9	exon22	c.3721_3723del	p.V1241del	exonic	ENSG00000108797.12	.	nonframeshift deletion	ENSG00000108797.12:ENST00000264638.9:exon22:c.3721_3723del:p.V1241del	17q21.2	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNTNAP1	525	0	570	102	0.151785714285714	TRUE	TRUE
ENSG00000076662.10	.	BCM	GRCh38.p13	chr19	10333915	10333920	+	GGCAGA	GGCAGA	-	In_Frame_Del	DEL	ENST00000160262.10	exon7	c.1581_1586del	p.P529_L530del	exonic	ENSG00000076662.10	.	nonframeshift deletion	ENSG00000076662.10:ENST00000160262.10:exon7:c.1581_1586del:p.P529_L530del	19p13.2	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ICAM3	223	0	263	44	0.143322475570033	TRUE	TRUE
ENSG00000179846.9	.	BCM	GRCh38.p13	chr19	45152057	45152057	+	G	G	A	Missense_Mutation	SNP	ENST00000317951.5	exon3	c.C1714T	p.R572C	exonic	ENSG00000179846.9	.	nonsynonymous SNV	ENSG00000179846.9:ENST00000317951.5:exon3:c.C1714T:p.R572C	19q13.32	C3N-02579	.	.	.	.	.	.	.	.	.	1.18	.	D	P	B	N	N	N	T	.	0.126	T	T	T	0.065	0.299	0.427	1.452	T	T	T	T	T	T	1.578	16.230	0.839	N	N	-0.494	1.189	-0.540	1.139	1.000	0.598	0.551	0.607	0.639	.	4.670	3.630	0.492	1.054	0.526	0.000	0.087	0.020	929	.	.	.	.	NKPD1	341	0	407	105	0.205078125	TRUE	TRUE
ENSG00000104884.16	.	BCM	GRCh38.p13	chr19	45355719	45355719	+	G	G	A	Missense_Mutation	SNP	ENST00000391945.10	exon16	c.C1489T	p.R497C	exonic	ENSG00000104884.16	.	nonsynonymous SNV	ENSG00000104884.16:ENST00000391945.10:exon16:c.C1489T:p.R497C	19q13.32	C3N-02579	4.124e-05	0	8.649e-05	0.0002	0	3e-05	0	0	rs199738290	16.20	D	D	P	B	D	D	M	D	D	0.864	T	T	D	0.673	.	0.899	0.319	D	D	D	D	D	D	3.568	24.900	0.999	D	D	0.207	3.332	0.281	3.607	0.109	0.707	0.702	0.698	0.714	.	5.680	4.640	3.341	0.227	0.676	1.000	0.553	0.995	911	.	.	.	.	ERCC2	466	1	530	80	0.131147540983607	TRUE	TRUE
ENSG00000105053.11	.	BCM	GRCh38.p13	chr19	49979146	49979146	+	T	T	G	Missense_Mutation	SNP	ENST00000316763.8	exon14	c.A1373C	p.Q458P	exonic	ENSG00000105053.11	.	nonsynonymous SNV	ENSG00000105053.11:ENST00000316763.8:exon14:c.A1373C:p.Q458P	19q13.33	C3N-02579	.	.	.	.	.	.	.	.	.	5.20	D	D	P	B	N	D	M	T	D	0.529	T	T	T	0.118	0.420	0.336	0.326	T	T	T	T	T	T	1.925	18.680	0.972	N	N	-0.396	1.391	-0.394	1.383	0.001	0.706	0.725	0.710	0.711	.	4.820	3.780	0.821	1.126	0.665	0.013	0.372	0.236	687	Protein_kinase_domain	.	.	.	VRK3	156	0	194	46	0.191666666666667	TRUE	TRUE
ENSG00000198959.12	.	BCM	GRCh38.p13	chr20	38132440	38132440	+	T	T	A	Missense_Mutation	SNP	ENST00000361475.7	exon11	c.A1676T	p.N559I	exonic	ENSG00000198959.12	.	nonsynonymous SNV	ENSG00000198959.12:ENST00000361475.7:exon11:c.A1676T:p.N559I	20q11.23	C3N-02579	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.893	T	T	D	0.406	0.641	0.596	0.950	T	T	D	T	D	T	3.974	26.800	0.993	D	D	0.549	5.438	0.473	4.923	1.000	0.722	0.588	0.604	0.735	.	4.670	4.670	4.087	1.049	0.665	1.000	0.954	0.915	865	Transglutaminase,_C-terminal	.	.	.	TGM2	450	0	556	179	0.243537414965986	TRUE	TRUE
ENSG00000234409.7	.	BCM	GRCh38.p13	chr22	20148649	20148649	+	G	G	T	Missense_Mutation	SNP	ENST00000439765.4	exon9	c.C1174A	p.L392M	exonic	ENSG00000234409.7	.	nonsynonymous SNV	ENSG00000234409.7:ENST00000439765.4:exon9:c.C1174A:p.L392M	22q11.21	C3N-02579	.	.	.	.	.	.	.	.	.	3.9	.	D	.	.	.	.	.	.	.	0.525	.	.	.	.	.	0.085	.	T	T	T	T	D	T	3.411	24.400	0.994	D	N	-0.353	1.489	-0.322	1.520	0.959	0.660	0.514	0.576	0.592	.	4.460	1.090	1.691	0.231	0.654	1.000	0.997	0.961	798	.	.	.	.	CCDC188	184	0	240	65	0.213114754098361	TRUE	TRUE
ENSG00000184571.13	.	BCM	GRCh38.p13	chr22	24754168	24754168	+	C	C	T	Missense_Mutation	SNP	ENST00000332271.9	exon8	c.G823A	p.E275K	exonic	ENSG00000184571.13	.	nonsynonymous SNV	ENSG00000184571.13:ENST00000332271.9:exon8:c.G823A:p.E275K	22q11.23	C3N-02579	.	.	.	.	.	.	.	.	rs775556342	10.20	D	D	D	D	U	D	M	T	D	0.623	T	T	T	0.174	.	0.393	0.572	T	T	T	T	D	D	3.249	24.000	0.999	D	N	0.315	3.856	0.101	2.741	1.000	0.487	0.574	0.547	0.527	.	2.420	2.420	4.911	0.697	0.449	1.000	0.094	0.051	483	.	.	.	ID=COSV59993917;OCCURENCE=1(large_intestine),2(skin)	PIWIL3	155	0	229	63	0.215753424657534	TRUE	TRUE
ENSG00000123165.8	.	BCM	GRCh38.p13	chrX	128052112	128052112	+	C	C	T	Missense_Mutation	SNP	ENST00000371124.4	exon1	c.G95A	p.R32H	exonic	ENSG00000123165.8	.	nonsynonymous SNV	ENSG00000123165.8:ENST00000371124.4:exon1:c.G95A:p.R32H	Xq25	C3N-02579	3.444e-05	0.0001	0.0001	0.0002	0	0	0	0	rs185459023	11.19	D	D	D	D	N	N	M	D	D	0.163	D	D	D	0.305	.	0.942	0.028	T	D	T	T	T	T	0.829	9.682	0.988	N	.	.	.	.	.	0.000	.	.	.	.	.	3.760	-1.180	1.073	-1.779	-1.973	0.142	0.000	0.000	900	.	.	.	ID=COSV100947479;OCCURENCE=1(stomach),1(lung)	ACTRT1	122	1	190	29	0.132420091324201	TRUE	NA
ENSG00000144057.15	.	BCM	GRCh38.p13	chr2	106843177	106843177	+	G	G	A	Silent	SNP	ENST00000409382.7	exon2	c.C801T	p.T267T	exonic	ENSG00000144057.15	.	synonymous SNV	ENSG00000144057.15:ENST00000409382.7:exon2:c.C801T:p.T267T	2q12.3	C3N-02579	9.156e-05	0	0	0	0	0.0002	0	0	rs559643382	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ST6GAL2	103	0	142	44	0.236559139784946	TRUE	NA
ENSG00000187054.15	.	BCM	GRCh38.p13	chr4	67929938	67929938	+	A	A	G	Silent	SNP	ENST00000334830.11	exon5	c.T432C	p.N144N	exonic	ENSG00000187054.15	.	synonymous SNV	ENSG00000187054.15:ENST00000334830.11:exon5:c.T432C:p.N144N	4q13.2	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMPRSS11A	95	0	116	22	0.159420289855072	TRUE	TRUE
ENSG00000138650.9	.	BCM	GRCh38.p13	chr4	133151289	133151289	+	T	T	A	Silent	SNP	ENST00000264360.7	exon1	c.T1149A	p.T383T	exonic	ENSG00000138650.9	.	synonymous SNV	ENSG00000138650.9:ENST00000264360.7:exon1:c.T1149A:p.T383T	4q28.3	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDH10	205	0	289	50	0.147492625368732	TRUE	TRUE
ENSG00000112852.7	.	BCM	GRCh38.p13	chr5	141095885	141095885	+	C	C	A	Silent	SNP	ENST00000194155.7	exon1	c.C1095A	p.T365T	exonic	ENSG00000112852.7	.	synonymous SNV	ENSG00000112852.7:ENST00000194155.7:exon1:c.C1095A:p.T365T	5q31.3	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHB2	209	0	229	83	0.266025641025641	TRUE	TRUE
ENSG00000111912.20	.	BCM	GRCh38.p13	chr6	125885299	125885299	+	C	C	T	Silent	SNP	ENST00000392477.7	exon8	c.C840T	p.L280L	exonic	ENSG00000111912.20	.	synonymous SNV	ENSG00000111912.20:ENST00000392477.7:exon8:c.C840T:p.L280L	6q22.32	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NCOA7	118	0	107	42	0.281879194630872	TRUE	TRUE
ENSG00000164941.14	.	BCM	GRCh38.p13	chr8	94871902	94871902	+	T	T	C	Silent	SNP	ENST00000523731.6	exon21	c.T2433C	p.F811F	exonic	ENSG00000164941.14	.	synonymous SNV	ENSG00000164941.14:ENST00000523731.6:exon21:c.T2433C:p.F811F	8q22.1	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INTS8	146	0	197	49	0.199186991869919	TRUE	TRUE
ENSG00000185187.13	.	BCM	GRCh38.p13	chr11	407115	407115	+	G	G	T	Silent	SNP	ENST00000431843.7	exon7	c.C675A	p.I225I	exonic	ENSG00000185187.13	.	synonymous SNV	ENSG00000185187.13:ENST00000431843.7:exon7:c.C675A:p.I225I	11p15.5	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SIGIRR	199	0	277	72	0.206303724928367	TRUE	TRUE
ENSG00000135452.10	.	BCM	GRCh38.p13	chr12	57745756	57745756	+	G	G	A	Silent	SNP	ENST00000257910.8	exon2	c.G75A	p.L25L	exonic	ENSG00000135452.10	.	synonymous SNV	ENSG00000135452.10:ENST00000257910.8:exon2:c.G75A:p.L25L	12q14.1	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TSPAN31	165	0	196	37	0.158798283261803	TRUE	TRUE
ENSG00000197838.5	.	BCM	GRCh38.p13	chr19	41091905	41091905	+	G	G	A	Silent	SNP	ENST00000330436.4	exon5	c.G828A	p.Q276Q	exonic	ENSG00000197838.5	.	synonymous SNV	ENSG00000197838.5:ENST00000330436.4:exon5:c.G828A:p.Q276Q	19q13.2	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CYP2A13	134	0	152	36	0.191489361702128	NA	TRUE
ENSG00000105287.12	.	BCM	GRCh38.p13	chr19	46704575	46704575	+	G	G	A	Silent	SNP	ENST00000433867.5	exon5	c.C586T	p.L196L	exonic	ENSG00000105287.12	.	synonymous SNV	ENSG00000105287.12:ENST00000433867.5:exon5:c.C586T:p.L196L	19q13.32	C3N-02579	3.317e-05	0	8.651e-05	0	0	4.527e-05	0	0	rs747367197	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRKD2	225	0	265	45	0.145161290322581	TRUE	NA
ENSG00000142235.11	.	BCM	GRCh38.p13	chr19	48510120	48510120	+	C	C	T	Silent	SNP	ENST00000600059.5	exon3	c.G264A	p.A88A	exonic	ENSG00000142235.11	.	synonymous SNV	ENSG00000142235.11:ENST00000600059.5:exon3:c.G264A:p.A88A	19q13.33	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54311884;OCCURENCE=1(central_nervous_system),1(skin)	LMTK3	149	0	212	38	0.152	TRUE	TRUE
ENSG00000183579.16	.	BCM	GRCh38.p13	chr22	28987168	28987168	+	G	G	A	Silent	SNP	ENST00000544604.7	exon2	c.G393A	p.L131L	exonic	ENSG00000183579.16	.	synonymous SNV	ENSG00000183579.16:ENST00000544604.7:exon2:c.G393A:p.L131L	22q12.1	C3N-02579	1.658e-05	0	0.0002	0	0	0	0	0	rs746248781	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNRF3	92	0	164	35	0.175879396984925	TRUE	NA
ENSG00000120910.14	.	BCM	GRCh38.p13	chr8	22523643	22523643	+	A	A	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000120910.14	.	.	.	8p21.3	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPP3CC	108	0	126	28	0.181818181818182	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65502756	65502756	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	100	1	151	10	0.062111801242236	TRUE	NA
ENSG00000139915.21	.	BCM	GRCh38.p13	chr14	46871859	46871859	+	G	G	-	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000139915.21	.	.	.	14q21.3	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MDGA2	94	0	120	26	0.178082191780822	TRUE	NA
ENSG00000286759.1	.	BCM	GRCh38.p13	chr16	81160850	81160850	+	G	G	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000286759.1;ENSG00000166473.17	dist=6874;dist=9439	.	.	16q23.2	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC092718.9	374	1	375	99	0.208860759493671	TRUE	NA
ENSG00000206775.1	.	BCM	GRCh38.p13	chr19	3982564	3982564	+	A	A	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000206775.1	.	.	.	19p13.3	C3N-02579	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SNORD37	134	1	135	22	0.140127388535032	TRUE	NA
ENSG00000116031.9	.	BCM	GRCh38.p13	chr2	70833696	70833696	+	C	C	T	Missense_Mutation	SNP	ENST00000410009.5	exon3	c.G515A	p.R172Q	exonic	ENSG00000116031.9	.	nonsynonymous SNV	ENSG00000116031.9:ENST00000410009.5:exon3:c.G515A:p.R172Q	2p13.3	C3N-03000	0.0004	0	0	0.0001	0	1.535e-05	0	0.0029	rs567546839	0.19	T	T	B	B	N	N	N	T	N	0.070	T	T	.	0.007	0.401	0.170	0.160	T	T	T	T	T	T	0.336	4.703	0.581	N	N	-1.529	0.073	-1.564	0.086	0.117	0.497	0.590	0.547	0.542	.	4.120	-3.860	-0.555	-1.016	-0.224	0.000	0.001	0.003	877	.	.	.	ID=COSV69652518;OCCURENCE=1(liver),1(central_nervous_system)	CD207	99	0	96	8	0.0769230769230769	TRUE	TRUE
ENSG00000240303.8	.	BCM	GRCh38.p13	chr3	132642132	132642132	+	C	C	T	Missense_Mutation	SNP	ENST00000264990.11	exon4	c.G377A	p.G126D	exonic	ENSG00000240303.8	.	nonsynonymous SNV	ENSG00000240303.8:ENST00000264990.11:exon4:c.G377A:p.G126D	3q22.1	C3N-03000	.	.	.	.	.	.	.	.	.	16.18	D	D	D	D	.	D	H	T	D	0.967	D	D	D	0.638	0.944	0.915	0.739	.	T	D	D	D	D	4.421	31	0.999	D	D	1.049	15.527	0.941	15.603	1.000	0.706	0.710	0.653	0.759	.	5.490	5.490	7.058	1.026	0.599	1.000	1.000	0.996	856	Aminoglycoside_phosphotransferase	.	.	.	ACAD11	82	0	41	11	0.211538461538462	TRUE	TRUE
ENSG00000284862.3	.	BCM	GRCh38.p13	chr3	180642006	180642006	+	G	G	A	Missense_Mutation	SNP	ENST00000476379.6	exon13	c.C1861T	p.R621W	exonic	ENSG00000284862.3	.	nonsynonymous SNV	ENSG00000284862.3:ENST00000476379.6:exon13:c.C1861T:p.R621W	3q26.33	C3N-03000	2.506e-05	0	8.658e-05	0	0	3.016e-05	0	0	rs771462228	12.19	D	D	D	D	D	D	M	.	D	0.849	T	T	D	0.401	.	0.520	0.351	T	T	T	D	T	T	3.868	26.200	0.999	D	D	0.435	4.566	0.325	3.864	0.007	0.554	0.588	0.618	0.564	.	4.900	1.760	1.272	1.155	0.618	1.000	0.972	0.998	552	.	.	.	ID=COSV56484104;OCCURENCE=1(soft_tissue)	CCDC39	56	0	33	4	0.108108108108108	TRUE	TRUE
ENSG00000197410.14	.	BCM	GRCh38.p13	chr4	154234724	154234724	+	G	G	A	Missense_Mutation	SNP	ENST00000357232.10	exon20	c.C9928T	p.R3310C	exonic	ENSG00000197410.14	.	nonsynonymous SNV	ENSG00000197410.14:ENST00000357232.10:exon20:c.C9928T:p.R3310C	4q31.3	C3N-03000	2.473e-05	0	0.0002	0	0	1.5e-05	0	0	rs759791153	2.11	.	.	.	.	N	D	.	.	.	.	T	T	T	0.196	.	.	0.100	T	.	T	T	D	.	3.328	24.200	0.995	N	N	0.413	4.428	0.377	4.198	0.098	0.487	0.574	0.550	0.564	.	5.930	5.930	2.420	1.176	0.676	0.052	0.444	0.966	745	.	.	.	ID=COSV61767417;OCCURENCE=1(pancreas),1(prostate)	DCHS2	119	0	83	20	0.194174757281553	TRUE	TRUE
ENSG00000204963.6	.	BCM	GRCh38.p13	chr5	140835917	140835917	+	G	G	A	Missense_Mutation	SNP	ENST00000525929.2	exon1	c.G1534A	p.A512T	exonic	ENSG00000204963.6	.	nonsynonymous SNV	ENSG00000204963.6:ENST00000525929.2:exon1:c.G1534A:p.A512T	5q31.3	C3N-03000	.	.	.	.	.	.	.	.	.	5.19	D	D	P	P	U	D	N	T	D	0.277	T	T	T	0.062	0.373	0.605	.	.	T	T	T	D	T	3.261	24.000	0.996	N	N	-0.282	1.659	-0.351	1.462	0.000	0.554	0.574	0.409	0.568	.	4.010	1.990	-0.740	0.982	0.498	0.000	1.000	0.947	31	Cadherin-like	.	.	.	PCDHA7	930	0	718	69	0.0876747141041931	NA	TRUE
ENSG00000248383.4	.	BCM	GRCh38.p13	chr5	140929090	140929090	+	C	C	G	Nonsense_Mutation	SNP	ENST00000253807.2	exon1	c.C2198G	p.S733X	exonic	ENSG00000248383.4	.	stopgain	ENSG00000248383.4:ENST00000253807.2:exon1:c.C2198G:p.S733X	5q31.3	C3N-03000	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	D	.	.	.	0.055	.	.	.	.	.	.	.	.	.	D	D	.	.	5.829	35	0.980	N	N	0.160	3.130	-0.170	1.858	0.018	0.653	0.588	0.676	0.530	.	5.950	-0.875	0.037	0.126	0.599	0.001	0.977	0.982	60	Cadherin,_cytoplasmic_C-terminal_domain	.	.	.	PCDHAC1	223	0	138	22	0.1375	TRUE	TRUE
ENSG00000145990.11	.	BCM	GRCh38.p13	chr6	13365165	13365165	+	C	C	A	Missense_Mutation	SNP	ENST00000379287.4	exon2	c.G751T	p.V251L	exonic	ENSG00000145990.11	.	nonsynonymous SNV	ENSG00000145990.11:ENST00000379287.4:exon2:c.G751T:p.V251L	6p24.1	C3N-03000	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	L	T	N	0.409	T	T	T	0.122	0.750	0.587	0.990	T	T	T	T	D	D	2.436	22.200	0.994	D	D	0.114	2.942	0.300	3.720	1.000	0.672	0.702	0.616	0.636	.	5.730	5.730	4.994	1.026	0.594	1.000	0.997	0.987	866	.	.	.	.	GFOD1	369	0	234	35	0.130111524163569	TRUE	TRUE
ENSG00000204560.10	.	BCM	GRCh38.p13	chr6	30660142	30660142	+	G	G	C	Missense_Mutation	SNP	ENST00000376442.8	exon10	c.C1645G	p.L549V	exonic	ENSG00000204560.10	.	nonsynonymous SNV	ENSG00000204560.10:ENST00000376442.8:exon10:c.C1645G:p.L549V	6p21.33	C3N-03000	.	.	.	.	.	.	.	.	.	7.19	D	D	P	B	D	D	N	T	D	0.274	T	T	T	0.232	0.673	0.453	0.603	T	T	T	T	D	.	2.064	19.750	0.995	D	N	-0.212	1.844	-0.174	1.850	1.000	0.707	0.702	0.725	0.714	.	4.900	3.060	0.323	0.222	0.676	0.088	1.000	0.998	856	Helicase_superfamily_1/2,_ATP-binding_domain;DEAD/DEAH_box_helicase_domain	.	.	.	DHX16	41	0	29	5	0.147058823529412	TRUE	TRUE
ENSG00000064999.15	.	BCM	GRCh38.p13	chr6	35017795	35017795	+	A	A	T	Missense_Mutation	SNP	ENST00000360359.5	exon11	c.A1746T	p.E582D	exonic	ENSG00000064999.15	.	nonsynonymous SNV	ENSG00000064999.15:ENST00000360359.5:exon11:c.A1746T:p.E582D	6p21.31	C3N-03000	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	L	T	N	0.076	T	T	T	0.108	0.064	0.252	0.298	T	T	T	T	T	T	1.635	16.600	0.979	D	N	-0.662	0.878	-0.511	1.183	1.000	0.626	0.654	0.805	0.373	.	5.140	1.220	0.823	0.230	0.756	0.992	0.800	0.974	409	.	.	.	.	ANKS1A	520	0	432	40	0.0847457627118644	TRUE	TRUE
ENSG00000197753.11	.	BCM	GRCh38.p13	chr6	35814606	35814606	+	G	G	A	Missense_Mutation	SNP	ENST00000360215.3	exon2	c.G473A	p.R158Q	exonic	ENSG00000197753.11	.	nonsynonymous SNV	ENSG00000197753.11:ENST00000360215.3:exon2:c.G473A:p.R158Q	6p21.31	C3N-03000	8.244e-06	0	0	0	0	0	0	6.056e-05	rs566829909	6.19	T	D	B	B	D	D	.	T	N	0.430	T	T	D	0.170	0.766	0.584	0.510	T	T	T	T	T	D	2.792	23.000	0.999	D	N	0.027	2.609	0.169	3.037	0.466	0.554	0.588	0.547	0.567	.	5.390	4.400	3.402	1.176	0.676	1.000	0.999	0.980	485	.	.	.	ID=COSV104420417;OCCURENCE=1(large_intestine)	LHFPL5	507	0	363	69	0.159722222222222	TRUE	NA
ENSG00000074706.13	.	BCM	GRCh38.p13	chr6	154212804	154212804	+	G	G	A	Missense_Mutation	SNP	ENST00000265198.8	exon9	c.C500T	p.P167L	exonic	ENSG00000074706.13;ENSG00000288520.1	.	nonsynonymous SNV	ENSG00000074706.13:ENST00000265198.8:exon9:c.C500T:p.P167L,ENSG00000288520.1:ENST00000673182.1:exon19:c.C1886T:p.P629L	6q25.2	C3N-03000	.	.	.	.	.	.	.	.	.	7.20	D	D	P	P	D	N	M	T	D	0.419	T	T	T	0.116	0.331	0.168	0.779	T	T	T	T	D	D	2.484	22.400	0.997	N	N	0.094	2.863	0.013	2.405	0.073	0.554	0.546	0.618	0.564	.	5.930	4.160	3.511	1.176	0.676	0.980	0.164	0.867	944	.	.	.	.	IPCEF1	121	0	107	7	0.0614035087719298	TRUE	TRUE
ENSG00000104213.13	.	BCM	GRCh38.p13	chr8	17642770	17642770	+	C	C	A	Missense_Mutation	SNP	ENST00000251630.11	exon6	c.C1097A	p.T366N	exonic	ENSG00000104213.13	.	nonsynonymous SNV	ENSG00000104213.13:ENST00000251630.11:exon6:c.C1097A:p.T366N	8p22	C3N-03000	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	N	0.782	T	T	D	0.322	0.542	0.841	0.027	T	T	T	T	D	D	3.622	25.100	0.992	D	D	0.723	7.447	0.687	7.510	1.000	0.672	0.588	0.653	0.711	.	5.420	5.420	7.186	0.947	0.599	1.000	0.914	0.924	731	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	PDGFRL	210	0	154	23	0.129943502824859	TRUE	TRUE
ENSG00000095303.17	.	BCM	GRCh38.p13	chr9	122378453	122378453	+	C	C	T	Missense_Mutation	SNP	ENST00000362012.7	exon4	c.C232T	p.R78W	exonic	ENSG00000095303.17	.	nonsynonymous SNV	ENSG00000095303.17:ENST00000362012.7:exon4:c.C232T:p.R78W	9q33.2	C3N-03000	0.0021	0.0003	0.0203	0	0	0.0001	0.0011	0.0005	rs181947887	11.19	D	D	D	P	D	D	M	T	D	0.571	T	T	.	0.420	.	0.903	0.724	T	T	T	D	T	D	3.375	24.300	0.999	D	D	0.306	3.813	0.287	3.642	1.000	0.707	0.588	0.659	0.714	.	5.680	5.680	0.979	1.026	0.599	0.000	0.943	0.850	878	.	.	.	ID=COSV56292653;OCCURENCE=1(central_nervous_system),1(ovary)	PTGS1	237	0	214	14	0.0614035087719298	TRUE	TRUE
ENSG00000119922.10	.	BCM	GRCh38.p13	chr10	89307062	89307062	+	C	C	T	Missense_Mutation	SNP	ENST00000371826.4	exon2	c.C1106T	p.A369V	exonic	ENSG00000119922.10	.	nonsynonymous SNV	ENSG00000119922.10:ENST00000371826.4:exon2:c.C1106T:p.A369V	10q23.31	C3N-03000	8.286e-06	0	0	0	0	1.499e-05	0	0	rs768227773	0.20	T	T	B	B	U	N	N	T	N	0.042	T	T	T	0.013	0.209	0.173	0.180	T	T	T	T	T	T	-0.500	0.119	0.742	N	N	-1.666	0.042	-1.803	0.033	1.000	0.707	0.725	0.547	0.616	.	4.580	-8.230	-0.749	-1.509	-2.027	0.000	0.000	0.000	818	.	.	.	ID=COSV51079533;OCCURENCE=2(large_intestine),1(haematopoietic_and_lymphoid_tissue)	IFIT2	271	0	246	16	0.0610687022900763	TRUE	TRUE
ENSG00000166169.17	.	BCM	GRCh38.p13	chr10	101579722	101579722	+	G	G	A	Missense_Mutation	SNP	ENST00000370162.8	exon9	c.C1459T	p.R487W	exonic	ENSG00000166169.17	.	nonsynonymous SNV	ENSG00000166169.17:ENST00000370162.8:exon9:c.C1459T:p.R487W	10q24.32	C3N-03000	3.314e-05	0	0	0	0	3.019e-05	0	0.0001	rs113383598	17.20	D	D	D	D	D	D	H	T	D	0.933	D	T	D	0.588	.	0.739	0.699	T	D	D	D	D	D	4.248	29.100	0.999	D	D	0.859	10.049	0.748	8.759	1.000	0.707	0.702	0.702	0.714	.	5.250	4.340	5.205	1.176	0.676	1.000	0.993	0.927	372	DNA-directed_DNA_polymerase_X;DNA_polymerase_beta,_palm_domain	.	.	ID=COSV54574776;OCCURENCE=1(stomach)	POLL	398	0	297	25	0.077639751552795	TRUE	TRUE
ENSG00000148843.15	.	BCM	GRCh38.p13	chr10	103443969	103443969	+	G	G	A	Missense_Mutation	SNP	ENST00000369797.8	exon34	c.G5179A	p.V1727M	exonic	ENSG00000148843.15	.	nonsynonymous SNV	ENSG00000148843.15:ENST00000369797.8:exon34:c.G5179A:p.V1727M	10q24.33	C3N-03000	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.671	T	T	T	0.326	0.342	0.600	0.788	T	T	D	T	D	D	4.290	29.500	0.999	D	D	0.702	7.142	0.677	7.346	1.000	0.646	0.702	0.698	0.723	.	5.670	4.760	8.029	1.176	0.676	1.000	0.994	0.906	228	Tetratricopeptide_repeat-containing_domain;Suppressor_of_forked	.	.	.	PDCD11	252	0	238	14	0.0555555555555556	TRUE	NA
ENSG00000175229.7	.	BCM	GRCh38.p13	chr11	66043412	66043412	+	G	G	A	Missense_Mutation	SNP	ENST00000312006.5	exon3	c.C391T	p.R131C	exonic	ENSG00000175229.7	.	nonsynonymous SNV	ENSG00000175229.7:ENST00000312006.5:exon3:c.C391T:p.R131C	11q13.1	C3N-03000	1.967e-05	0	0	0	0	3.62e-05	0	0	rs150888474	16.20	D	D	D	D	D	D	H	T	D	0.959	T	T	D	0.600	.	0.829	2.081	D	T	D	D	D	D	4.566	32	0.999	D	D	0.903	11.127	0.820	10.756	1.000	0.696	0.547	0.723	0.542	.	4.620	4.620	9.922	1.172	0.676	1.000	1.000	0.985	199	.	.	.	ID=COSV61748859;OCCURENCE=1(oesophagus)	GAL3ST3	337	0	322	30	0.0852272727272727	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-03000	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	281	0	190	73	0.277566539923954	TRUE	TRUE
ENSG00000184613.10	.	BCM	GRCh38.p13	chr12	44665573	44665573	+	C	C	T	Missense_Mutation	SNP	ENST00000429094.6	exon13	c.G1355A	p.R452H	exonic	ENSG00000184613.10	.	nonsynonymous SNV	ENSG00000184613.10:ENST00000429094.6:exon13:c.G1355A:p.R452H	12q12	C3N-03000	1.65e-05	0	8.649e-05	0	0	1.501e-05	0	0	rs750566671	9.20	T	T	D	P	D	D	N	D	N	0.570	T	T	D	0.597	0.488	0.731	0.200	T	T	T	D	T	D	2.037	19.540	0.319	D	D	0.145	3.069	0.281	3.610	0.832	0.706	0.574	0.710	0.564	.	5.280	4.380	4.728	1.026	0.599	1.000	0.996	0.956	799	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	ID=COSV61570866;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	NELL2	144	0	92	8	0.08	TRUE	TRUE
ENSG00000060709.15	.	BCM	GRCh38.p13	chr12	130414226	130414226	+	G	G	A	Missense_Mutation	SNP	ENST00000261655.8	exon14	c.C2551T	p.R851W	exonic	ENSG00000060709.15	.	nonsynonymous SNV	ENSG00000060709.15:ENST00000261655.8:exon14:c.C2551T:p.R851W	12q24.33	C3N-03000	8.264e-06	0	8.642e-05	0	0	0	0	0	rs769276085	16.20	D	D	D	D	D	D	H	T	D	0.918	T	T	D	0.431	0.599	0.642	0.978	T	D	D	D	D	D	4.240	29.000	0.999	D	D	0.839	9.585	0.736	8.483	1.000	0.638	0.670	0.489	0.564	.	4.370	4.370	6.509	1.176	0.676	1.000	0.899	0.925	994	SH3_domain	.	.	ID=COSV55478173;OCCURENCE=2(pancreas)	RIMBP2	153	0	84	22	0.207547169811321	TRUE	TRUE
ENSG00000102805.16	.	BCM	GRCh38.p13	chr13	77000944	77000944	+	G	G	A	Missense_Mutation	SNP	ENST00000377453.9	exon4	c.G1052A	p.R351K	exonic	ENSG00000102805.16	.	nonsynonymous SNV	ENSG00000102805.16:ENST00000377453.9:exon4:c.G1052A:p.R351K	13q22.3	C3N-03000	.	.	.	.	.	.	.	.	.	0.16	.	.	B	B	N	N	L	.	.	.	T	T	T	0.029	0.409	0.231	0.184	T	T	T	T	T	T	-0.084	0.897	0.445	N	N	-1.742	0.030	-1.745	0.043	1.000	0.732	0.744	0.670	0.728	.	4.930	-2.320	0.191	-0.675	-0.782	0.003	0.022	0.589	899	.	.	.	.	CLN5	97	0	103	7	0.0636363636363636	TRUE	TRUE
ENSG00000070729.14	.	BCM	GRCh38.p13	chr16	57950483	57950483	+	G	G	A	Missense_Mutation	SNP	ENST00000251102.13	exon13	c.C932T	p.P311L	exonic	ENSG00000070729.14	.	nonsynonymous SNV	ENSG00000070729.14:ENST00000251102.13:exon13:c.C932T:p.P311L	16q21	C3N-03000	0.0001	0	0	0	0.0002	0.0001	0	0.0003	rs369817749	10.20	D	D	D	P	N	N	L	D	D	0.465	D	D	D	0.395	.	0.870	0.340	T	T	T	T	D	T	2.595	22.600	0.998	D	N	0.057	2.720	-0.006	2.337	0.999	0.487	0.574	0.547	0.542	.	4.440	4.440	2.747	0.221	-0.111	0.879	0.004	0.046	824	.	.	.	ID=COSV51897283;OCCURENCE=1(kidney)	CNGB1	381	0	355	23	0.0608465608465608	TRUE	TRUE
ENSG00000171724.3	.	BCM	GRCh38.p13	chr16	77817036	77817036	+	G	G	A	Missense_Mutation	SNP	ENST00000302536.3	exon2	c.G349A	p.V117M	exonic	ENSG00000171724.3	.	nonsynonymous SNV	ENSG00000171724.3:ENST00000302536.3:exon2:c.G349A:p.V117M	16q23.1	C3N-03000	.	.	.	.	.	.	.	.	rs1035718136	12.20	D	D	D	P	D	D	H	T	D	0.567	T	T	D	0.339	0.848	0.446	0.507	T	T	T	T	D	D	3.943	26.600	0.999	D	D	0.872	10.349	0.826	10.934	0.999	0.732	0.588	0.744	0.616	.	5.800	5.800	5.270	1.176	0.618	1.000	1.000	0.999	937	Polyketide_synthase,_enoylreductase_domain;Alcohol_dehydrogenase,_N-terminal	.	.	ID=COSV56820606;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	VAT1L	141	0	105	6	0.0540540540540541	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673802	7673802	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G818A	p.R273H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G818A:p.R273H	17p13.1	C3N-03000	2.628e-05	0	0	0	0	4.746e-05	0	0	rs28934576	19.20	D	D	D	D	D	A	M	D	D	0.965	D	D	D	0.868	.	0.997	0.264	T	D	D	D	D	D	3.527	24.800	0.998	D	D	0.383	4.238	0.333	3.915	1.000	0.722	0.702	0.725	0.735	.	4.920	4.920	7.905	1.022	0.596	1.000	0.856	0.980	432	p53,_DNA-binding_domain	.	.	ID=COSV52660980;OCCURENCE=3(salivary_gland),135(breast),5(penis),9(liver),2(genital_tract),55(oesophagus),3(adrenal_gland),1(cervix),301(large_intestine),84(central_nervous_system),18(biliary_tract),1(fallopian_tube),1(pleura),4(vulva),73(ovary),8(bone),6(NS),57(haematopoietic_and_lymphoid_tissue),60(stomach),23(urinary_tract),7(soft_tissue),9(kidney),55(pancreas),15(skin),22(prostate),111(lung),11(thyroid),66(upper_aerodigestive_tract),2(thymus),41(endometrium)	TP53	607	0	405	99	0.196428571428571	TRUE	TRUE
ENSG00000109061.10	.	BCM	GRCh38.p13	chr17	10497149	10497149	+	G	G	A	Missense_Mutation	SNP	ENST00000226207.6	exon33	c.C4576T	p.R1526C	exonic	ENSG00000109061.10	.	nonsynonymous SNV	ENSG00000109061.10:ENST00000226207.6:exon33:c.C4576T:p.R1526C	17p13.1	C3N-03000	6.607e-05	0	8.655e-05	0.0003	0	1.502e-05	0	0.0002	rs141906658	8.20	D	D	P	B	U	D	M	T	N	0.389	T	T	D	0.376	0.613	0.783	0.244	T	D	T	T	T	T	3.367	24.300	0.998	D	D	0.239	3.479	0.380	4.220	0.091	0.487	0.590	0.574	0.564	.	5.660	5.660	2.071	1.176	0.676	0.792	0.998	0.995	169	Myosin_tail	.	.	.	MYH1	223	0	137	8	0.0551724137931034	TRUE	NA
ENSG00000076604.15	.	BCM	GRCh38.p13	chr17	28748653	28748653	+	G	G	A	Missense_Mutation	SNP	ENST00000262395.10	exon6	c.G767A	p.G256D	exonic	ENSG00000076604.15	.	nonsynonymous SNV	ENSG00000076604.15:ENST00000262395.10:exon6:c.G767A:p.G256D	17q11.2	C3N-03000	8.36e-06	0	0	0	0	1.525e-05	0	0	rs757460687	18.20	D	D	D	D	D	D	H	T	D	0.852	D	D	D	0.726	0.739	0.810	1.992	T	D	D	D	D	D	4.182	28.500	0.998	D	D	1.033	15.005	0.971	17.184	1.000	0.722	0.672	0.699	0.711	.	5.650	5.650	9.173	1.176	0.676	1.000	0.998	0.994	122	Zinc_finger,_TRAF-type	.	.	ID=COSV99286374;OCCURENCE=1(biliary_tract)	TRAF4	143	0	97	22	0.184873949579832	TRUE	NA
ENSG00000105290.13	.	BCM	GRCh38.p13	chr19	35871682	35871682	+	G	G	A	Missense_Mutation	SNP	ENST00000652533.1	exon5	c.G608A	p.R203H	exonic	ENSG00000105290.13	.	nonsynonymous SNV	ENSG00000105290.13:ENST00000652533.1:exon5:c.G608A:p.R203H	19q13.12	C3N-03000	2.472e-05	0	0	0.0002	0	0	0	6.057e-05	rs781528434	11.20	T	T	D	D	N	D	L	D	N	0.401	D	D	D	0.761	0.752	0.890	1.241	T	T	T	D	T	D	3.357	24.300	0.999	D	D	0.388	4.269	0.387	4.269	1.000	0.706	0.588	0.710	0.655	.	4.410	4.410	5.726	1.083	0.676	1.000	0.999	0.978	862	Amyloidogenic_glycoprotein,_extracellular;Amyloidogenic_glycoprotein,_copper-binding	.	.	ID=COSV55701542;OCCURENCE=1(large_intestine),1(central_nervous_system),1(urinary_tract),1(skin)	APLP1	351	0	359	23	0.0602094240837696	TRUE	TRUE
ENSG00000161681.15	.	BCM	GRCh38.p13	chr19	50662185	50662185	+	G	G	A	Missense_Mutation	SNP	ENST00000293441.5	exon23	c.C6266T	p.P2089L	exonic	ENSG00000161681.15	.	nonsynonymous SNV	ENSG00000161681.15:ENST00000293441.5:exon23:c.C6266T:p.P2089L	19q13.33	C3N-03000	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	U	D	L	T	D	0.534	T	T	D	0.357	0.287	0.661	0.690	D	D	T	T	D	D	4.218	28.800	0.976	D	D	0.649	6.456	0.603	6.257	1.000	0.646	0.547	0.645	0.586	.	3.660	3.660	9.739	1.164	0.654	1.000	0.992	0.998	862	.	.	.	.	SHANK1	116	0	144	10	0.0649350649350649	TRUE	NA
ENSG00000101191.17	.	BCM	GRCh38.p13	chr20	62879315	62879315	+	C	C	T	Missense_Mutation	SNP	ENST00000395343.6	exon16	c.G6641A	p.R2214Q	exonic	ENSG00000101191.17	.	nonsynonymous SNV	ENSG00000101191.17:ENST00000395343.6:exon16:c.G6641A:p.R2214Q	20q13.33	C3N-03000	3.883e-05	0.0004	0	0	0	0	0	0	rs369703114	5.20	D	T	P	B	N	N	M	T	D	0.109	T	T	D	0.071	.	0.443	0.589	T	T	T	T	T	T	2.116	20.200	0.998	D	N	0.001	2.516	0.014	2.408	1.000	0.789	0.694	0.768	0.604	.	5.290	4.320	1.546	0.070	-0.192	0.009	0.940	0.609	804	.	.	.	.	DIDO1	238	0	237	17	0.0669291338582677	TRUE	NA
ENSG00000100427.16	.	BCM	GRCh38.p13	chr22	50084845	50084845	+	G	G	A	Missense_Mutation	SNP	ENST00000311597.10	exon2	c.C58T	p.R20W	exonic	ENSG00000100427.16	.	nonsynonymous SNV	ENSG00000100427.16:ENST00000311597.10:exon2:c.C58T:p.R20W	22q13.33	C3N-03000	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.475	D	D	D	0.738	0.435	0.923	0.909	T	D	D	D	D	D	4.033	27.200	0.998	D	D	0.152	3.096	0.045	2.521	1.000	0.616	0.627	0.618	0.542	.	5.540	0.936	3.740	-0.322	-0.148	1.000	0.238	0.234	934	.	.	.	.	MLC1	433	0	324	37	0.102493074792244	TRUE	NA
ENSG00000189401.3	.	BCM	GRCh38.p13	chrX	70063155	70063155	+	G	G	A	Missense_Mutation	SNP	ENST00000338352.3	exon1	c.G631A	p.V211M	exonic	ENSG00000189401.3	.	nonsynonymous SNV	ENSG00000189401.3:ENST00000338352.3:exon1:c.G631A:p.V211M	Xq13.1	C3N-03000	.	.	.	.	.	.	.	.	.	7.19	D	T	D	D	D	N	M	T	N	0.113	T	T	D	0.124	0.450	0.355	0.974	T	T	T	T	D	T	1.356	14.780	0.996	N	.	.	.	.	.	0.083	.	.	.	.	.	4.420	3.560	1.803	0.225	0.618	0.429	0.002	0.002	170	OTU_domain	.	.	ID=COSV57972732;OCCURENCE=2(breast),1(parathyroid),1(endometrium)	OTUD6A	99	0	91	5	0.0520833333333333	TRUE	TRUE
ENSG00000154358.21	.	BCM	GRCh38.p13	chr1	228362715	228362715	+	C	C	T	Silent	SNP	ENST00000422127.5	exon80	c.C18801T	p.T6267T	exonic	ENSG00000154358.21	.	synonymous SNV	ENSG00000154358.21:ENST00000422127.5:exon80:c.C18801T:p.T6267T	1q42.13	C3N-03000	4.611e-05	0	0	0	0	8.587e-05	0	0	rs753136423	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52782753;OCCURENCE=1(central_nervous_system)	OBSCN	86	0	83	14	0.144329896907216	TRUE	TRUE
ENSG00000144218.19	.	BCM	GRCh38.p13	chr2	99593939	99593939	+	G	G	A	Silent	SNP	ENST00000409236.6	exon13	c.C1722T	p.N574N	exonic	ENSG00000144218.19	.	synonymous SNV	ENSG00000144218.19:ENST00000409236.6:exon13:c.C1722T:p.N574N	2q11.2	C3N-03000	0.0002	0	0	0.0006	0.0003	0.0002	0	0	rs771387532	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57841769;OCCURENCE=1(large_intestine)	AFF3	39	0	15	12	0.444444444444444	TRUE	TRUE
ENSG00000138798.13	.	BCM	GRCh38.p13	chr4	109963231	109963231	+	A	A	G	Silent	SNP	ENST00000265171.10	exon9	c.A1371G	p.V457V	exonic	ENSG00000138798.13	.	synonymous SNV	ENSG00000138798.13:ENST00000265171.10:exon9:c.A1371G:p.V457V	4q25	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EGF	454	0	273	47	0.146875	TRUE	TRUE
ENSG00000239389.8	.	BCM	GRCh38.p13	chr5	140883951	140883951	+	C	C	T	Silent	SNP	ENST00000289272.3	exon1	c.C1683T	p.N561N	exonic	ENSG00000239389.8	.	synonymous SNV	ENSG00000239389.8:ENST00000289272.3:exon1:c.C1683T:p.N561N	5q31.3	C3N-03000	8.444e-06	0	0	0	0	1.54e-05	0	0	rs782324778	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56486193;OCCURENCE=1(large_intestine),1(stomach),1(prostate)	PCDHA13	719	0	520	61	0.104991394148021	NA	TRUE
ENSG00000081853.15	.	BCM	GRCh38.p13	chr5	141340693	141340693	+	C	C	T	Silent	SNP	ENST00000394576.3	exon1	c.C1722T	p.G574G	exonic	ENSG00000081853.15	.	synonymous SNV	ENSG00000081853.15:ENST00000394576.3:exon1:c.C1722T:p.G574G	5q31.3	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53912616;OCCURENCE=1(large_intestine),1(skin)	PCDHGA2	550	0	464	32	0.0645161290322581	NA	TRUE
ENSG00000148082.10	.	BCM	GRCh38.p13	chr9	89071244	89071244	+	C	C	T	Silent	SNP	ENST00000375835.9	exon5	c.G738A	p.A246A	exonic	ENSG00000148082.10	.	synonymous SNV	ENSG00000148082.10:ENST00000375835.9:exon5:c.G738A:p.A246A	9q22.1	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SHC3	227	0	151	33	0.179347826086957	TRUE	NA
ENSG00000167355.8	.	BCM	GRCh38.p13	chr11	5343066	5343066	+	G	G	A	Silent	SNP	ENST00000300773.3	exon1	c.C459T	p.S153S	exonic	ENSG00000167355.8	.	synonymous SNV	ENSG00000167355.8:ENST00000300773.3:exon1:c.C459T:p.S153S	11p15.4	C3N-03000	2.502e-05	0	0	0	0	4.55e-05	0	0	rs62000378	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR51B5	140	0	72	22	0.234042553191489	TRUE	NA
ENSG00000166928.11	.	BCM	GRCh38.p13	chr11	60416414	60416414	+	C	C	A	Silent	SNP	ENST00000300187.11	exon5	c.C1446A	p.S482S	exonic	ENSG00000166928.11	.	synonymous SNV	ENSG00000166928.11:ENST00000300187.11:exon5:c.C1446A:p.S482S	11q12.2	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MS4A14	310	0	226	15	0.0622406639004149	TRUE	TRUE
ENSG00000174516.15	.	BCM	GRCh38.p13	chr11	66473820	66473820	+	C	C	T	Silent	SNP	ENST00000320740.12	exon7	c.C735T	p.G245G	exonic	ENSG00000174516.15	.	synonymous SNV	ENSG00000174516.15:ENST00000320740.12:exon7:c.C735T:p.G245G	11q13.2	C3N-03000	8.282e-06	0	0	0	0	0	0	6.058e-05	rs773772009	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PELI3	370	0	336	26	0.0718232044198895	TRUE	NA
ENSG00000211899.10	.	BCM	GRCh38.p13	chr14	105852214	105852214	+	G	G	A	Silent	SNP	ENST00000637539.2	exon5	c.C1350T	p.T450T	exonic	ENSG00000211899.10	.	synonymous SNV	ENSG00000211899.10:ENST00000637539.2:exon5:c.C1350T:p.T450T	14q32.33	C3N-03000	1.052e-05	0	0	0	0	1.856e-05	0	0	rs756477133	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHM	629	0	539	49	0.0833333333333333	TRUE	NA
ENSG00000213424.9	.	BCM	GRCh38.p13	chr17	40657357	40657357	+	A	A	C	Silent	SNP	ENST00000394052.5	exon5	c.T654G	p.T218T	exonic	ENSG00000213424.9;ENSG00000264058.2	.	synonymous SNV	ENSG00000213424.9:ENST00000394052.5:exon5:c.T654G:p.T218T,ENSG00000264058.2:ENST00000476049.1:exon5:c.T654G:p.T218T	17q21.2	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KRT222	82	0	71	5	0.0657894736842105	NA	TRUE
ENSG00000005007.13	.	BCM	GRCh38.p13	chr19	18852182	18852182	+	C	C	T	Silent	SNP	ENST00000599848.5	exon6	c.C858T	p.D286D	exonic	ENSG00000005007.13	.	synonymous SNV	ENSG00000005007.13:ENST00000599848.5:exon6:c.C858T:p.D286D	19p13.11	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53194445;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	UPF1	180	0	107	47	0.305194805194805	TRUE	TRUE
ENSG00000181215.15	.	BCM	GRCh38.p13	chr4	5989703	5989703	+	G	G	A	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000181215.15	dist=56	.	.	4p16.2	C3N-03000	.	.	.	.	.	.	.	.	rs892390528	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C4orf50	126	0	114	15	0.116279069767442	TRUE	NA
ENSG00000124549.14	.	BCM	GRCh38.p13	chr6	26423199	26423199	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000124549.14	.	.	.	6p22.2	C3N-03000	8.238e-05	0.0004	0	0.0001	0	2.997e-05	0.0011	0.0001	rs368563402	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BTN2A3P	205	0	178	29	0.140096618357488	TRUE	NA
ENSG00000234773.7	.	BCM	GRCh38.p13	chr19	12250004	12250004	+	C	C	G	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000234773.7;ENSG00000213293.4	dist=40198;dist=10122	.	.	19p13.2	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC012618.3	138	0	103	21	0.169354838709677	TRUE	NA
ENSG00000101292.7	.	BCM	GRCh38.p13	chr20	5316021	5316021	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000101292.7;ENSG00000266908.2	dist=1652;dist=2247	.	.	20p12.3	C3N-03000	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PROKR2	296	0	276	17	0.0580204778156997	TRUE	NA
ENSG00000142173.16	.	BCM	GRCh38.p13	chr21	46129203	46129203	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000142173.16	.	.	.	21q22.3	C3N-03000	0.0001	0	8.715e-05	0	0	0.0002	0	0.0003	rs201135253	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL6A2	345	0	263	51	0.162420382165605	TRUE	NA
ENSG00000163349.22	.	BCM	GRCh38.p13	chr1	113954722	113954722	+	G	G	T	Missense_Mutation	SNP	ENST00000426820.7	exon4	c.G1272T	p.R424S	exonic	ENSG00000163349.22	.	nonsynonymous SNV	ENSG00000163349.22:ENST00000426820.7:exon4:c.G1272T:p.R424S	1p13.2	C3L-00598	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	L	T	D	0.898	T	T	T	0.295	0.631	0.873	1.855	D	T	D	D	D	D	3.953	26.700	0.998	D	N	0.457	4.719	0.465	4.857	0.587	0.732	0.654	0.710	0.728	.	5.000	4.020	2.235	0.226	0.676	1.000	0.999	0.997	505	Protein_kinase_domain	.	.	.	HIPK1	153	1	259	52	0.167202572347267	TRUE	TRUE
ENSG00000162729.14	.	BCM	GRCh38.p13	chr1	160094985	160094985	+	G	G	A	Missense_Mutation	SNP	ENST00000314485.12	exon2	c.C326T	p.A109V	exonic	ENSG00000162729.14	.	nonsynonymous SNV	ENSG00000162729.14:ENST00000314485.12:exon2:c.C326T:p.A109V	1q23.2	C3L-00598	.	.	.	.	.	.	.	.	.	6.20	D	T	P	B	N	N	M	T	D	0.439	T	T	T	0.112	0.482	0.399	0.305	T	T	T	T	D	T	2.056	19.680	0.998	D	D	-0.082	2.233	0.013	2.403	1.000	0.722	0.725	0.699	0.613	.	5.040	5.040	4.192	0.226	0.676	0.998	0.002	0.102	754	Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV58757715;OCCURENCE=1(stomach)	IGSF8	254	0	674	136	0.167901234567901	TRUE	TRUE
ENSG00000136546.16	.	BCM	GRCh38.p13	chr2	166427882	166427882	+	C	C	T	Nonsense_Mutation	SNP	ENST00000643258.1	exon18	c.G2759A	p.W920X	exonic	ENSG00000136546.16	.	stopgain	ENSG00000136546.16:ENST00000643258.1:exon18:c.G2759A:p.W920X	2q24.3	C3L-00598	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.906	.	.	.	.	.	.	.	.	.	D	D	.	.	8.080	41	0.996	D	N	0.828	9.358	0.663	7.114	1.000	0.554	0.574	0.618	0.613	.	5.020	5.020	7.905	1.026	0.549	1.000	0.982	0.516	556	Sodium_ion_transport-associated	.	.	.	SCN7A	167	0	400	28	0.0654205607476635	TRUE	TRUE
ENSG00000128713.14	.	BCM	GRCh38.p13	chr2	176107621	176107621	+	G	G	T	Missense_Mutation	SNP	ENST00000249504.7	exon1	c.G266T	p.S89I	exonic	ENSG00000128713.14	.	nonsynonymous SNV	ENSG00000128713.14:ENST00000249504.7:exon1:c.G266T:p.S89I	2q31.1	C3L-00598	.	.	.	.	.	.	.	.	.	6.19	D	D	B	B	.	N	N	D	N	0.231	T	D	D	0.234	0.289	0.820	.	D	T	T	T	T	T	1.947	18.850	0.960	N	N	-0.672	0.860	-0.611	1.029	1.000	0.598	0.658	0.608	0.639	.	1.740	1.740	0.559	0.063	-0.865	0.993	0.085	0.007	745	.	.	.	.	HOXD11	24	0	70	25	0.263157894736842	TRUE	TRUE
ENSG00000114654.7	.	BCM	GRCh38.p13	chr3	129032902	129032902	+	G	G	A	Missense_Mutation	SNP	ENST00000436022.2	exon4	c.G1219A	p.E407K	exonic	ENSG00000114654.7	.	nonsynonymous SNV	ENSG00000114654.7:ENST00000436022.2:exon4:c.G1219A:p.E407K	3q21.3	C3L-00598	.	.	.	.	.	.	.	.	.	1.16	.	T	B	B	.	N	L	.	.	0.126	T	T	D	0.039	0.173	0.014	.	T	T	T	T	T	T	1.007	11.710	0.991	N	N	-0.923	0.491	-0.910	0.607	0.996	0.517	0.547	0.479	0.613	.	4.870	1.880	1.818	0.171	0.614	0.048	0.024	0.139	602	.	.	.	ID=COSV104714601;OCCURENCE=1(skin)	EFCC1	110	0	252	74	0.226993865030675	TRUE	TRUE
ENSG00000090402.8	.	BCM	GRCh38.p13	chr3	165009352	165009352	+	G	G	A	Missense_Mutation	SNP	ENST00000264382.8	exon35	c.C4106T	p.S1369F	exonic	ENSG00000090402.8	.	nonsynonymous SNV	ENSG00000090402.8:ENST00000264382.8:exon35:c.C4106T:p.S1369F	3q26.1	C3L-00598	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	N	N	M	D	D	0.407	D	D	D	0.364	0.471	0.937	0.215	T	D	D	T	D	D	2.975	23.400	0.997	N	N	0.266	3.610	0.084	2.671	0.000	0.487	0.574	0.574	0.564	.	4.510	2.610	1.516	1.155	0.618	0.058	0.541	0.415	848	.	.	.	.	SI	198	0	242	66	0.214285714285714	TRUE	TRUE
ENSG00000090530.10	.	BCM	GRCh38.p13	chr3	189958000	189958000	+	C	C	T	Missense_Mutation	SNP	ENST00000319332.10	exon15	c.G2039A	p.R680Q	exonic	ENSG00000090530.10	.	nonsynonymous SNV	ENSG00000090530.10:ENST00000319332.10:exon15:c.G2039A:p.R680Q	3q28	C3L-00598	3.297e-05	9.615e-05	8.649e-05	0	0	1.499e-05	0	6.06e-05	rs571855250	14.20	D	D	D	P	D	D	M	T	D	0.825	T	T	D	0.301	0.610	0.454	0.376	T	T	D	D	D	D	4.226	28.900	1.000	D	D	0.647	6.434	0.693	7.625	1.000	0.706	0.710	0.644	0.542	.	5.620	5.620	7.358	1.026	0.599	1.000	1.000	0.998	826	.	.	.	ID=COSV60020942;OCCURENCE=1(large_intestine)	P3H2	381	0	478	113	0.191201353637902	TRUE	TRUE
ENSG00000168214.20	.	BCM	GRCh38.p13	chr4	26430929	26430934	+	AAACAG	AAACAG	-	In_Frame_Del	DEL	ENST00000342295.5	exon12	c.1425_1430del	p.N476_S477del	exonic	ENSG00000168214.20	.	nonframeshift deletion	ENSG00000168214.20:ENST00000342295.5:exon12:c.1425_1430del:p.N476_S477del	4p15.2	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBPJ	419	0	582	131	0.183730715287518	TRUE	TRUE
ENSG00000109674.4	.	BCM	GRCh38.p13	chr4	177341483	177341483	+	A	A	C	Missense_Mutation	SNP	ENST00000264596.4	exon6	c.A710C	p.K237T	exonic	ENSG00000109674.4	.	nonsynonymous SNV	ENSG00000109674.4:ENST00000264596.4:exon6:c.A710C:p.K237T	4q34.3	C3L-00598	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.628	T	T	D	0.333	0.468	0.501	0.647	T	T	T	T	D	D	3.365	24.300	0.998	D	D	0.556	5.507	0.471	4.905	1.000	0.706	0.588	0.710	0.655	.	5.620	5.620	5.759	1.312	0.756	1.000	0.989	0.707	975	.	.	.	.	NEIL3	96	0	199	47	0.191056910569106	NA	TRUE
ENSG00000175416.15	.	BCM	GRCh38.p13	chr5	176392882	176392884	+	CTT	CTT	-	In_Frame_Del	DEL	ENST00000310418.8	exon6	c.580_582del	p.K194del	exonic	ENSG00000175416.15	.	nonframeshift deletion	ENSG00000175416.15:ENST00000310418.8:exon6:c.580_582del:p.K194del	5q35.2	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLTB	281	0	675	132	0.163568773234201	TRUE	TRUE
ENSG00000182348.7	.	BCM	GRCh38.p13	chr7	89336776	89336776	+	G	G	A	Missense_Mutation	SNP	ENST00000333190.5	exon4	c.G3794A	p.G1265D	exonic	ENSG00000182348.7	.	nonsynonymous SNV	ENSG00000182348.7:ENST00000333190.5:exon4:c.G3794A:p.G1265D	7q21.13	C3L-00598	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	N	D	M	T	D	0.663	T	T	T	0.172	0.233	0.378	0.273	T	T	T	T	D	T	3.388	24.400	0.995	D	D	0.384	4.247	0.343	3.977	0.115	0.616	0.574	0.575	0.564	.	5.290	4.400	4.851	0.199	-0.153	1.000	0.979	0.876	910	.	.	.	.	ZNF804B	276	0	429	145	0.252613240418118	TRUE	NA
ENSG00000164794.9	.	BCM	GRCh38.p13	chr8	109968230	109968230	+	A	A	C	Missense_Mutation	SNP	ENST00000524391.6	exon4	c.T1361G	p.L454R	exonic	ENSG00000164794.9	.	nonsynonymous SNV	ENSG00000164794.9:ENST00000524391.6:exon4:c.T1361G:p.L454R	8q23.2	C3L-00598	.	.	.	.	.	.	.	.	.	14.20	D	T	D	P	D	D	N	D	N	0.795	D	D	D	0.765	0.680	0.955	2.770	D	T	D	D	D	T	3.448	24.500	0.998	D	D	0.504	5.070	0.590	6.095	0.011	0.554	0.588	0.547	0.564	.	5.650	5.650	8.818	1.312	0.756	1.000	0.998	0.998	703	.	.	.	.	KCNV1	268	0	450	104	0.187725631768953	TRUE	TRUE
ENSG00000151224.13	.	BCM	GRCh38.p13	chr10	80280724	80280724	+	C	C	T	Missense_Mutation	SNP	ENST00000372213.8	exon4	c.G361A	p.V121I	exonic	ENSG00000151224.13	.	nonsynonymous SNV	ENSG00000151224.13:ENST00000372213.8:exon4:c.G361A:p.V121I	10q22.3	C3L-00598	3.295e-05	0	0	0	0	2.997e-05	0	0.0001	rs545505182	16.20	D	D	D	D	D	D	H	D	N	0.270	D	D	D	0.647	.	0.633	0.502	T	D	T	T	D	D	3.319	24.200	0.999	D	D	0.727	7.519	0.626	6.561	1.000	0.615	0.563	0.616	0.564	.	5.430	4.530	5.855	1.026	0.599	1.000	0.959	0.811	946	.	.	.	ID=COSV64747269;OCCURENCE=1(lung)	MAT1A	562	1	983	235	0.192939244663383	TRUE	TRUE
ENSG00000149305.7	.	BCM	GRCh38.p13	chr11	113932381	113932381	+	C	C	T	Missense_Mutation	SNP	ENST00000260191.7	exon5	c.C461T	p.A154V	exonic	ENSG00000149305.7	.	nonsynonymous SNV	ENSG00000149305.7:ENST00000260191.7:exon5:c.C461T:p.A154V	11q23.2	C3L-00598	8.237e-06	0	0	0	0	1.499e-05	0	0	rs770088313	14.20	D	D	D	D	D	D	M	T	N	0.318	T	T	D	0.506	0.724	0.894	0.484	T	T	D	D	D	D	2.748	22.900	0.999	D	D	0.449	4.662	0.490	5.067	1.000	0.447	0.563	0.492	0.530	.	5.820	5.820	6.176	1.026	0.599	1.000	0.851	0.501	864	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	ID=COSV52746850;OCCURENCE=1(large_intestine),1(small_intestine)	HTR3B	200	0	322	55	0.145888594164456	TRUE	TRUE
ENSG00000166535.20	.	BCM	GRCh38.p13	chr12	8850220	8850220	+	C	C	T	Missense_Mutation	SNP	ENST00000299698.12	exon18	c.C2180T	p.S727F	exonic	ENSG00000166535.20	.	nonsynonymous SNV	ENSG00000166535.20:ENST00000299698.12:exon18:c.C2180T:p.S727F	12p13.31	C3L-00598	.	.	.	.	.	.	.	.	.	5.20	D	D	P	B	N	N	M	T	D	0.429	T	T	T	0.085	0.423	0.102	0.344	T	T	T	T	D	T	2.551	22.500	0.994	N	N	-0.289	1.642	-0.330	1.504	0.229	0.732	0.590	0.744	0.564	.	3.480	2.570	1.052	1.026	0.599	0.954	0.644	0.253	728	.	.	.	.	A2ML1	173	0	423	64	0.131416837782341	TRUE	NA
ENSG00000121361.5	.	BCM	GRCh38.p13	chr12	21766177	21766177	+	C	C	T	Missense_Mutation	SNP	ENST00000240662.3	exon3	c.G821A	p.R274H	exonic	ENSG00000121361.5	.	nonsynonymous SNV	ENSG00000121361.5:ENST00000240662.3:exon3:c.G821A:p.R274H	12p12.1	C3L-00598	5.774e-05	0.0002	0	0	0	7.501e-05	0	0	rs149127157	8.20	T	T	B	B	D	D	N	D	N	0.351	D	D	D	0.327	.	0.871	1.682	T	D	T	T	T	D	2.261	21.300	0.997	N	N	-0.004	2.495	0.179	3.084	0.203	0.554	0.574	0.618	0.542	.	5.350	5.350	1.772	1.010	0.580	1.000	1.000	0.998	746	.	.	.	ID=COSV53715525;OCCURENCE=1(urinary_tract),2(lung)	KCNJ8	134	0	213	99	0.317307692307692	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-00598	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	348	0	475	197	0.293154761904762	TRUE	TRUE
ENSG00000181803.3	.	BCM	GRCh38.p13	chr14	20641295	20641295	+	G	G	A	Missense_Mutation	SNP	ENST00000320704.3	exon1	c.C397T	p.R133C	exonic	ENSG00000181803.3	.	nonsynonymous SNV	ENSG00000181803.3:ENST00000320704.3:exon1:c.C397T:p.R133C	14q11.2	C3L-00598	5.772e-05	0.0002	0	0	0	4.499e-05	0.0011	6.071e-05	rs142856316	6.20	D	D	B	B	N	N	M	T	D	0.119	T	T	T	0.100	.	0.544	0.044	T	T	T	T	T	D	2.742	22.900	0.998	D	N	-0.027	2.418	0.081	2.659	0.634	0.598	0.551	0.547	0.639	.	5.760	4.800	1.066	1.158	0.656	0.086	0.912	0.974	940	GPCR,_rhodopsin-like,_7TM	.	.	.	OR6S1	178	0	337	69	0.169950738916256	TRUE	NA
ENSG00000211800.3	.	BCM	GRCh38.p13	chr14	22040893	22040893	+	C	C	T	Missense_Mutation	SNP	ENST00000390448.3	exon2	c.C77T	p.T26M	exonic	ENSG00000211800.3	.	nonsynonymous SNV	ENSG00000211800.3:ENST00000390448.3:exon2:c.C77T:p.T26M	14q11.2	C3L-00598	1.696e-05	0	0	0	0	3.073e-05	0	0	rs369305527	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRAV20	138	0	246	77	0.238390092879257	TRUE	NA
ENSG00000103966.11	.	BCM	GRCh38.p13	chr15	41919486	41919486	+	C	C	A	Missense_Mutation	SNP	ENST00000220325.9	exon4	c.G648T	p.K216N	exonic	ENSG00000103966.11	.	nonsynonymous SNV	ENSG00000103966.11:ENST00000220325.9:exon4:c.G648T:p.K216N	15q15.1	C3L-00598	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.958	D	D	D	0.863	0.706	0.975	1.465	D	D	D	D	D	D	3.406	24.400	0.999	D	D	0.671	6.736	0.556	5.716	1.000	0.722	0.702	0.725	0.735	.	5.320	3.410	1.808	0.138	0.599	1.000	0.999	0.976	116	Dynamin-type_guanine_nucleotide-binding_(G)_domain	.	.	.	EHD4	30	0	45	41	0.476744186046512	TRUE	TRUE
ENSG00000141096.6	.	BCM	GRCh38.p13	chr16	67980253	67980253	+	G	G	A	Missense_Mutation	SNP	ENST00000268793.6	exon1	c.C128T	p.P43L	exonic	ENSG00000141096.6	.	nonsynonymous SNV	ENSG00000141096.6:ENST00000268793.6:exon1:c.C128T:p.P43L	16q22.1	C3L-00598	.	.	.	.	.	.	.	.	.	3.15	D	D	.	.	N	N	.	T	N	0.109	T	T	T	0.074	.	0.225	1.281	T	.	T	T	D	.	1.018	11.850	0.991	N	N	-0.178	1.939	-0.360	1.446	0.394	0.696	0.547	0.692	0.613	.	3.240	3.240	0.413	0.149	-0.110	0.496	0.003	0.003	10	.	.	.	.	DPEP3	164	0	427	86	0.167641325536062	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675136	7675136	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.C476T	p.A159V	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.C476T:p.A159V	17p13.1	C3L-00598	.	.	.	.	.	.	.	.	.	18.20	D	D	D	P	D	D	M	D	D	0.672	D	D	D	0.774	0.863	0.952	1.552	T	D	D	D	D	D	3.504	24.700	0.998	D	D	0.022	2.591	-0.044	2.215	0.990	0.722	0.698	0.698	0.735	.	5.590	2.420	8.150	1.176	0.676	1.000	0.917	0.632	434	p53,_DNA-binding_domain	.	.	ID=COSV52674926;OCCURENCE=11(breast),3(liver),4(oesophagus),1(cervix),12(large_intestine),3(central_nervous_system),5(ovary),4(stomach),2(haematopoietic_and_lymphoid_tissue),5(urinary_tract),2(pancreas),5(skin),2(prostate),19(lung),1(thyroid),1(upper_aerodigestive_tract),3(endometrium)	TP53	403	0	404	167	0.292469352014011	TRUE	TRUE
ENSG00000179477.11	.	BCM	GRCh38.p13	chr17	8076266	8076266	+	G	G	A	Missense_Mutation	SNP	ENST00000647874.1	exon11	c.C1441T	p.L481F	exonic	ENSG00000179477.11	.	nonsynonymous SNV	ENSG00000179477.11:ENST00000647874.1:exon11:c.C1441T:p.L481F	17p13.1	C3L-00598	.	.	.	.	.	.	.	.	.	6.20	D	T	B	B	N	N	L	T	D	0.191	T	T	D	0.342	0.733	0.775	0.584	T	D	T	T	D	T	2.233	21.100	0.996	D	N	-0.236	1.778	-0.209	1.765	0.016	0.549	0.590	0.590	0.530	.	5.200	0.495	0.292	-0.226	-0.244	0.996	0.978	0.995	354	Lipoxygenase,_C-terminal	.	.	.	ALOX12B	454	0	526	190	0.26536312849162	TRUE	TRUE
ENSG00000154263.17	.	BCM	GRCh38.p13	chr17	69152396	69152396	+	C	C	T	Missense_Mutation	SNP	ENST00000269081.8	exon36	c.G4222A	p.D1408N	exonic	ENSG00000154263.17	.	nonsynonymous SNV	ENSG00000154263.17:ENST00000269081.8:exon36:c.G4222A:p.D1408N	17q24.3	C3L-00598	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	U	D	L	D	D	0.553	D	D	D	0.625	0.864	0.704	0.224	T	T	D	T	D	D	3.194	23.800	0.999	D	D	0.319	3.880	0.212	3.243	0.020	0.554	0.588	0.574	0.621	.	3.280	2.280	5.118	-0.253	0.526	1.000	0.039	0.311	892	ABC_transporter-like;AAA+_ATPase_domain	.	.	.	ABCA10	112	0	274	72	0.208092485549133	TRUE	TRUE
ENSG00000167210.17	.	BCM	GRCh38.p13	chr18	46477699	46477699	+	C	C	T	Missense_Mutation	SNP	ENST00000441551.6	exon39	c.G5977A	p.E1993K	exonic	ENSG00000167210.17	.	nonsynonymous SNV	ENSG00000167210.17:ENST00000441551.6:exon39:c.G5977A:p.E1993K	18q21.1	C3L-00598	9.169e-05	0.0005	0	0	0	0.0001	0	0	rs376559755	13.18	D	D	D	D	.	D	.	T	D	0.879	T	T	D	0.475	.	0.326	.	T	T	D	D	D	D	4.071	27.500	0.995	D	D	0.846	9.754	0.792	9.905	1.000	0.447	0.563	0.573	0.613	.	5.140	5.140	7.879	1.026	0.599	1.000	0.999	0.986	918	PLAT/LH2_domain	.	.	.	LOXHD1	968	2	1162	447	0.277812305779988	TRUE	NA
ENSG00000105141.6	.	BCM	GRCh38.p13	chr19	15053790	15053790	+	G	G	A	Missense_Mutation	SNP	ENST00000427043.4	exon4	c.G235A	p.V79I	exonic	ENSG00000105141.6	.	nonsynonymous SNV	ENSG00000105141.6:ENST00000427043.4:exon4:c.G235A:p.V79I	19p13.12	C3L-00598	0.0002	0	0.0002	0	0	0.0003	0	0	rs143520169	0.20	T	T	B	B	N	N	L	T	N	0.213	T	T	T	0.033	.	0.061	0.031	T	T	T	T	T	T	-0.442	0.157	0.855	N	N	-1.491	0.084	-1.532	0.096	0.000	0.487	0.590	0.574	0.564	.	5.050	-1.630	-0.007	-0.879	-1.077	0.098	0.021	0.006	970	Peptidase_C14A,_caspase_catalytic_domain;Peptidase_C14,__p20_domain	.	.	ID=COSV55667158;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	CASP14	230	1	339	85	0.200471698113208	TRUE	TRUE
ENSG00000160321.15	.	BCM	GRCh38.p13	chr19	21972609	21972609	+	C	C	T	Missense_Mutation	SNP	ENST00000397126.9	exon4	c.G2425A	p.E809K	exonic	ENSG00000160321.15	.	nonsynonymous SNV	ENSG00000160321.15:ENST00000397126.9:exon4:c.G2425A:p.E809K	19p12	C3L-00598	.	.	.	.	.	.	.	.	.	3.17	T	D	.	.	.	N	L	T	D	0.227	T	T	T	0.023	-	0.148	0.008	T	T	T	T	D	T	0.152	2.600	0.989	N	N	-0.529	1.120	-0.715	0.878	0.000	0.487	0.574	0.574	0.564	.	2.570	1.500	-0.600	-0.631	-0.790	0.000	0.005	0.003	988	Zinc_finger_C2H2-type	.	.	.	ZNF208	232	0	377	77	0.169603524229075	NA	TRUE
ENSG00000170604.5	.	BCM	GRCh38.p13	chr19	45884303	45884303	+	C	C	T	Missense_Mutation	SNP	ENST00000302165.5	exon1	c.G1472A	p.S491N	exonic	ENSG00000170604.5	.	nonsynonymous SNV	ENSG00000170604.5:ENST00000302165.5:exon1:c.G1472A:p.S491N	19q13.32	C3L-00598	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.065	T	T	T	0.073	0.207	0.082	.	T	T	T	T	D	T	1.206	13.680	0.481	N	N	-0.792	0.666	-0.722	0.869	1.000	0.543	0.686	0.269	0.636	.	4.490	4.490	2.427	1.026	0.599	0.009	0.722	0.320	702	.	.	.	.	IRF2BP1	133	0	334	85	0.202863961813842	TRUE	TRUE
ENSG00000131398.15	.	BCM	GRCh38.p13	chr19	50323406	50323406	+	C	C	T	Missense_Mutation	SNP	ENST00000477616.2	exon2	c.G1547A	p.G516E	exonic	ENSG00000131398.15	.	nonsynonymous SNV	ENSG00000131398.15:ENST00000477616.2:exon2:c.G1547A:p.G516E	19q13.33	C3L-00598	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	U	D	H	D	D	0.989	D	D	D	0.780	0.909	0.983	.	D	D	D	D	D	D	3.699	25.400	0.996	D	D	0.427	4.516	0.218	3.273	0.932	0.706	0.710	0.702	0.605	.	3.260	2.210	7.731	0.883	0.465	1.000	0.997	0.896	628	Ion_transport_domain	.	.	ID=COSV65387131;OCCURENCE=1(upper_aerodigestive_tract)	KCNC3	815	1	1177	305	0.205802968960864	TRUE	TRUE
ENSG00000242019.1	.	BCM	GRCh38.p13	chr19	54727752	54727752	+	G	G	A	Missense_Mutation	SNP	ENST00000291860.1	exon4	c.G497A	p.R166H	exonic	ENSG00000242019.1	.	nonsynonymous SNV	ENSG00000242019.1:ENST00000291860.1:exon4:c.G497A:p.R166H	19q13.42	C3L-00598	2.253e-05	0	0	0	0	3.967e-05	0	0	rs201591361	0.14	T	T	.	.	.	N	.	T	N	0.030	T	T	T	0.010	.	0.043	2.110	T	.	T	T	T	.	-0.329	0.270	0.471	N	N	-1.650	0.045	-1.702	0.051	0.000	0.487	0.574	0.574	0.564	.	1.200	-0.022	-0.798	0.012	-0.349	0.000	0.000	0.000	952	Immunoglobulin_subtype	.	.	ID=COSV52549600;OCCURENCE=1(large_intestine),1(lung)	KIR3DL3	289	0	638	163	0.203495630461923	TRUE	NA
ENSG00000101004.15	.	BCM	GRCh38.p13	chr20	25491413	25491413	+	C	C	T	Missense_Mutation	SNP	ENST00000278886.11	exon11	c.G1423A	p.D475N	exonic	ENSG00000101004.15	.	nonsynonymous SNV	ENSG00000101004.15:ENST00000278886.11:exon11:c.G1423A:p.D475N	20p11.21	C3L-00598	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	M	T	D	0.423	T	T	T	0.177	0.218	0.466	0.121	T	T	T	T	D	T	2.921	23.300	0.999	D	N	0.511	5.125	0.427	4.555	1.000	0.644	0.574	0.688	0.636	.	4.600	4.600	5.738	1.015	0.536	0.999	0.005	0.008	579	.	.	.	.	NINL	132	0	354	86	0.195454545454545	TRUE	TRUE
ENSG00000011201.12	.	BCM	GRCh38.p13	chrX	8597139	8597139	+	C	C	T	Missense_Mutation	SNP	ENST00000262648.8	exon4	c.G436A	p.A146T	exonic	ENSG00000011201.12	.	nonsynonymous SNV	ENSG00000011201.12:ENST00000262648.8:exon4:c.G436A:p.A146T	Xp22.31	C3L-00598	3.456e-05	0.0002	0.0001	0	0	0	0	0	rs144620955	9.19	D	D	D	D	D	D	L	T	N	0.557	T	T	D	0.562	.	0.922	1.674	T	T	T	T	T	D	3.074	23.600	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.510	4.510	6.705	0.877	0.599	1.000	0.565	0.599	1000	WAP-type_'four-disulfide_core'_domain	.	.	ID=COSV52916486;OCCURENCE=1(central_nervous_system)	ANOS1	586	0	1018	204	0.166939443535188	TRUE	TRUE
ENSG00000184368.16	.	BCM	GRCh38.p13	chrX	20052943	20052943	+	G	G	A	Missense_Mutation	SNP	ENST00000379651.7	exon5	c.C530T	p.T177M	exonic	ENSG00000184368.16	.	nonsynonymous SNV	ENSG00000184368.16:ENST00000379651.7:exon5:c.C530T:p.T177M	Xp22.12	C3L-00598	.	.	.	.	.	.	.	.	rs367603064	2.19	T	T	B	B	N	D	N	T	N	0.143	T	T	D	0.030	.	0.174	0.184	T	T	T	T	T	T	0.309	4.395	0.957	N	.	.	.	.	.	0.002	.	.	.	.	.	5.640	0.102	-0.023	1.172	0.672	0.628	0.999	0.997	60	.	.	.	ID=COSV65527236;OCCURENCE=1(large_intestine)	MAP7D2	235	0	498	106	0.175496688741722	TRUE	TRUE
ENSG00000102226.10	.	BCM	GRCh38.p13	chrX	47247838	47247838	+	C	C	T	Nonsense_Mutation	SNP	ENST00000218348.7	exon21	c.C2800T	p.R934X	exonic	ENSG00000102226.10	.	stopgain	ENSG00000102226.10:ENST00000218348.7:exon21:c.C2800T:p.R934X	Xp11.3	C3L-00598	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	N	D	.	.	.	0.783	.	.	.	.	.	.	.	.	.	D	D	.	.	5.636	34	0.995	N	.	.	.	.	.	1.000	.	.	.	.	.	4.690	4.690	0.560	1.026	0.593	0.058	0.114	0.784	548	.	.	.	.	USP11	130	1	255	80	0.238805970149254	TRUE	NA
ENSG00000126970.16	.	BCM	GRCh38.p13	chrX	64919125	64919125	+	C	C	T	Missense_Mutation	SNP	ENST00000374839.8	exon4	c.G478A	p.A160T	exonic	ENSG00000126970.16	.	nonsynonymous SNV	ENSG00000126970.16:ENST00000374839.8:exon4:c.G478A:p.A160T	Xq11.2	C3L-00598	2.396e-05	0.0001	0.0001	0	0	0	0	0	rs372946873	6.18	T	T	D	P	D	D	L	.	N	0.510	T	T	D	0.138	.	0.407	0.007	T	T	T	T	T	D	2.482	22.400	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.400	5.400	5.907	1.026	0.599	1.000	0.998	0.989	40	.	.	.	ID=COSV62005205;OCCURENCE=1(skin)	ZC4H2	96	0	141	31	0.180232558139535	TRUE	TRUE
ENSG00000198934.5	.	BCM	GRCh38.p13	chrX	76430676	76430676	+	C	C	T	Nonsense_Mutation	SNP	ENST00000361470.4	exon1	c.C2746T	p.R916X	exonic	ENSG00000198934.5	.	stopgain	ENSG00000198934.5:ENST00000361470.4:exon1:c.C2746T:p.R916X	Xq13.3	C3L-00598	.	.	.	.	.	.	.	.	.	3.4	.	.	.	.	.	D	.	.	.	0.066	.	.	.	.	.	.	.	.	.	D	D	.	.	4.443	31	0.991	N	.	.	.	.	.	0.001	.	.	.	.	.	2.000	0.034	-0.177	0.009	-0.204	0.133	0.998	0.991	203	MAGE_homology_domain	.	.	ID=COSV63912558;OCCURENCE=1(liver),1(stomach)	MAGEE1	202	0	446	104	0.189090909090909	TRUE	TRUE
ENSG00000185313.8	.	BCM	GRCh38.p13	chr3	38793740	38793740	+	C	C	-	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000185313.8	ENST00000449082.3:exon2:c.270+1G>-	.	.	3p22.2	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCN10A	123	0	250	57	0.185667752442997	TRUE	TRUE
ENSG00000113492.14	.	BCM	GRCh38.p13	chr5	35010151	35010151	+	T	T	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000113492.14	ENST00000231420.11:exon12:c.1189-2A>T	.	.	5p13.2	C3L-00598	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.398	34	0.995	D	.	1.072	16.369	0.909	14.121	1.000	0.066	0.061	0.060	0.075	0.977	5.670	5.670	7.479	1.138	0.665	1.000	0.966	0.694	722	.	.	.	.	AGXT2	419	0	589	158	0.211512717536814	TRUE	TRUE
ENSG00000018625.15	.	BCM	GRCh38.p13	chr1	160130218	160130218	+	G	G	A	Silent	SNP	ENST00000361216.8	exon12	c.G1578A	p.P526P	exonic	ENSG00000018625.15	.	synonymous SNV	ENSG00000018625.15:ENST00000361216.8:exon12:c.G1578A:p.P526P	1q23.2	C3L-00598	4.952e-05	0	0	0.0001	0	7.515e-05	0	0	rs376128790	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP1A2	529	1	912	246	0.212435233160622	TRUE	NA
ENSG00000196843.17	.	BCM	GRCh38.p13	chr2	96552190	96552190	+	C	C	T	Silent	SNP	ENST00000357485.8	exon7	c.C1662T	p.F554F	exonic	ENSG00000196843.17	.	synonymous SNV	ENSG00000196843.17:ENST00000357485.8:exon7:c.C1662T:p.F554F	2q11.2	C3L-00598	8.32e-06	0	0	0	0	0	0	6.112e-05	rs770664548	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARID5A	196	1	309	70	0.184696569920844	TRUE	NA
ENSG00000144357.17	.	BCM	GRCh38.p13	chr2	170079891	170079891	+	G	G	A	Silent	SNP	ENST00000272793.10	exon37	c.G5277A	p.Q1759Q	exonic	ENSG00000144357.17	.	synonymous SNV	ENSG00000144357.17:ENST00000272793.10:exon37:c.G5277A:p.Q1759Q	2q31.1	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBR3	243	0	305	66	0.177897574123989	TRUE	NA
ENSG00000145555.15	.	BCM	GRCh38.p13	chr5	16668415	16668415	+	G	G	A	Silent	SNP	ENST00000513610.6	exon40	c.C5937T	p.A1979A	exonic	ENSG00000145555.15	.	synonymous SNV	ENSG00000145555.15:ENST00000513610.6:exon40:c.C5937T:p.A1979A	5p15.1	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO10	98	0	258	62	0.19375	TRUE	TRUE
ENSG00000069018.19	.	BCM	GRCh38.p13	chr5	136356917	136356917	+	G	G	A	Silent	SNP	ENST00000513104.6	exon2	c.C471T	p.D157D	exonic	ENSG00000069018.19	.	synonymous SNV	ENSG00000069018.19:ENST00000513104.6:exon2:c.C471T:p.D157D	5q31.1	C3L-00598	8.278e-06	0	8.646e-05	0	0	0	0	0	rs753491646	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61456624;OCCURENCE=1(prostate),1(upper_aerodigestive_tract)	TRPC7	139	0	294	86	0.226315789473684	TRUE	TRUE
ENSG00000124587.14	.	BCM	GRCh38.p13	chr6	42964872	42964872	+	C	C	T	Silent	SNP	ENST00000304611.13	exon16	c.G2724A	p.Q908Q	exonic	ENSG00000124587.14	.	synonymous SNV	ENSG00000124587.14:ENST00000304611.13:exon16:c.G2724A:p.Q908Q	6p21.1	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PEX6	773	0	1162	253	0.178798586572438	TRUE	TRUE
ENSG00000120899.18	.	BCM	GRCh38.p13	chr8	27422330	27422330	+	C	C	T	Silent	SNP	ENST00000346049.10	exon5	c.C498T	p.Y166Y	exonic	ENSG00000120899.18	.	synonymous SNV	ENSG00000120899.18:ENST00000346049.10:exon5:c.C498T:p.Y166Y	8p21.2	C3L-00598	2.509e-05	9.735e-05	0	0	0	0	0	0.0001	rs527933742	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTK2B	106	0	169	32	0.159203980099502	TRUE	NA
ENSG00000140396.13	.	BCM	GRCh38.p13	chr8	70121350	70121350	+	G	G	A	Silent	SNP	ENST00000452400.7	exon22	c.C4335T	p.N1445N	exonic	ENSG00000140396.13	.	synonymous SNV	ENSG00000140396.13:ENST00000452400.7:exon22:c.C4335T:p.N1445N	8q13.3	C3L-00598	9.574e-06	0	0.0001	0	0	0	0	0	rs767106389	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NCOA2	245	0	558	111	0.165919282511211	TRUE	NA
ENSG00000095319.14	.	BCM	GRCh38.p13	chr9	128982954	128982954	+	G	G	A	Silent	SNP	ENST00000372577.2	exon17	c.G1722A	p.K574K	exonic	ENSG00000095319.14	.	synonymous SNV	ENSG00000095319.14:ENST00000372577.2:exon17:c.G1722A:p.K574K	9q34.11	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NUP188	248	0	264	83	0.239193083573487	TRUE	TRUE
ENSG00000150760.12	.	BCM	GRCh38.p13	chr10	127026372	127026372	+	C	C	T	Silent	SNP	ENST00000280333.9	exon16	c.C1509T	p.D503D	exonic	ENSG00000150760.12	.	synonymous SNV	ENSG00000150760.12:ENST00000280333.9:exon16:c.C1509T:p.D503D	10q26.2	C3L-00598	3.481e-05	0	0	0	0	7.392e-05	0	0	rs370668962	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DOCK1	356	0	612	157	0.204161248374512	TRUE	NA
ENSG00000183715.13	.	BCM	GRCh38.p13	chr11	132657112	132657112	+	C	C	T	Silent	SNP	ENST00000331898.11	exon2	c.G375A	p.T125T	exonic	ENSG00000183715.13	.	synonymous SNV	ENSG00000183715.13:ENST00000331898.11:exon2:c.G375A:p.T125T	11q25	C3L-00598	1.649e-05	0	0	0	0	0	0	0.0001	rs548104590	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59419763;OCCURENCE=1(large_intestine),1(endometrium)	OPCML	175	0	306	90	0.227272727272727	TRUE	TRUE
ENSG00000103449.12	.	BCM	GRCh38.p13	chr16	51140230	51140230	+	C	C	T	Silent	SNP	ENST00000251020.9	exon2	c.G1992A	p.P664P	exonic	ENSG00000103449.12	.	synonymous SNV	ENSG00000103449.12:ENST00000251020.9:exon2:c.G1992A:p.P664P	16q12.1	C3L-00598	0.0001	0	0	0.0015	0.0002	1.51e-05	0.0011	6.056e-05	rs754352358	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SALL1	242	0	380	103	0.213250517598344	TRUE	TRUE
ENSG00000141519.15	.	BCM	GRCh38.p13	chr17	80084895	80084895	+	C	C	T	Silent	SNP	ENST00000397545.9	exon13	c.C2142T	p.S714S	exonic	ENSG00000141519.15	.	synonymous SNV	ENSG00000141519.15:ENST00000397545.9:exon13:c.C2142T:p.S714S	17q25.3	C3L-00598	.	.	.	.	.	.	.	.	rs927736485	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC40	646	2	917	229	0.199825479930192	TRUE	NA
ENSG00000105143.12	.	BCM	GRCh38.p13	chr19	14962172	14962172	+	C	C	T	Silent	SNP	ENST00000221742.7	exon5	c.G765A	p.E255E	exonic	ENSG00000105143.12	.	synonymous SNV	ENSG00000105143.12:ENST00000221742.7:exon5:c.G765A:p.E255E	19p13.12	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC1A6	326	0	634	174	0.215346534653465	TRUE	TRUE
ENSG00000124191.18	.	BCM	GRCh38.p13	chr20	44006594	44006594	+	G	G	A	Silent	SNP	ENST00000358131.5	exon3	c.G240A	p.P80P	exonic	ENSG00000124191.18	.	synonymous SNV	ENSG00000124191.18:ENST00000358131.5:exon3:c.G240A:p.P80P	20q13.12	C3L-00598	6.623e-05	0	0	0	0.0005	6.019e-05	0	6.075e-05	rs774698912	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57881921;OCCURENCE=1(large_intestine),1(prostate)	TOX2	172	0	369	98	0.209850107066381	TRUE	TRUE
ENSG00000287916.1	.	BCM	GRCh38.p13	chr3	156273636	156273636	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000287916.1	.	.	.	3q25.31	C3L-00598	.	.	.	.	.	.	.	.	.	0.13	T	T	.	.	.	N	.	T	N	.	T	T	.	0.023	0.488	0.072	.	.	.	T	T	T	T	0.152	2.598	0.713	N	N	-1.175	0.245	-1.395	0.154	0.000	0.487	0.574	0.574	0.613	.	0.149	-0.298	-0.718	-0.486	-0.644	0.040	0.023	0.048	766	.	.	.	.	AC091607.2	178	0	312	78	0.2	TRUE	TRUE
ENSG00000072832.15	.	BCM	GRCh38.p13	chr4	5892632	5892632	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000072832.15;ENSG00000181215.15	dist=4151;dist=4959	.	.	4p16.2	C3L-00598	.	.	.	.	.	.	.	.	.	4.16	T	T	.	.	N	N	.	D	N	0.063	T	T	D	0.134	0.348	0.282	0.622	D	.	T	T	D	T	2.328	21.700	0.985	N	N	-0.385	1.416	-0.294	1.577	0.999	0.726	0.590	0.594	0.563	.	4.420	1.100	0.615	0.927	0.483	0.996	0.992	0.947	981	.	.	.	.	CRMP1	10	0	29	11	0.275	TRUE	TRUE
ENSG00000187821.8	.	BCM	GRCh38.p13	chr4	185020774	185020774	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000187821.8	ENST00000515777.5:c.*2G>A	.	.	4q35.1	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100132915;OCCURENCE=1(cervix),1(lung)	HELT	43	0	89	28	0.239316239316239	TRUE	NA
ENSG00000164199.18	.	BCM	GRCh38.p13	chr5	90781377	90781377	+	-	NA	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000164199.18	.	.	.	5q14.3	C3L-00598	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADGRV1	NA	NA	NA	NA	NA	NA	NA
ENSG00000067798.16	.	BCM	GRCh38.p13	chr12	78037056	78037056	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000067798.16	.	.	.	12q21.2	C3L-00598	.	.	.	.	.	.	.	.	.	1.3	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	1.013	11.790	0.773	N	.	.	.	.	.	0.241	0.062	0.063	0.091	0.090	0.164	5.720	3.360	1.460	0.239	-0.060	0.937	0.623	0.712	931	.	.	.	.	NAV3	173	0	223	76	0.254180602006689	TRUE	NA
ENSG00000121073.15	.	BCM	GRCh38.p13	chr17	49707912	49707912	+	C	C	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000121073.15	ENST00000240333.12:c.-79G>T	.	.	17q21.33	C3L-00598	2.622e-05	0	0	0	0	5.186e-05	0	0	rs777342365	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC35B1	182	0	453	131	0.224315068493151	TRUE	NA
ENSG00000162591.16	.	BCM	GRCh38.p13	chr1	3506126	3506126	+	C	C	T	Missense_Mutation	SNP	ENST00000356575.9	exon15	c.G1900A	p.G634S	exonic	ENSG00000162591.16	.	nonsynonymous SNV	ENSG00000162591.16:ENST00000356575.9:exon15:c.G1900A:p.G634S	1p36.32	C3N-03430	2.206e-05	0	0	0	0	4.22e-05	0	0	rs746964214	15.20	D	D	D	P	U	D	H	T	D	0.939	D	T	D	0.440	0.563	0.848	0.361	D	T	D	D	D	D	4.180	28.500	0.998	D	D	0.756	7.984	0.630	6.626	1.000	0.651	0.547	0.645	0.684	.	3.770	3.770	7.681	0.919	0.566	1.000	0.817	0.951	982	EGF-like,_conserved_site;EGF-like_domain;Laminin_EGF_domain	.	.	.	MEGF6	212	1	350	91	0.206349206349206	TRUE	NA
ENSG00000142627.13	.	BCM	GRCh38.p13	chr1	16148998	16148998	+	G	G	T	Missense_Mutation	SNP	ENST00000358432.8	exon3	c.C203A	p.S68Y	exonic	ENSG00000142627.13	.	nonsynonymous SNV	ENSG00000142627.13:ENST00000358432.8:exon3:c.C203A:p.S68Y	1p36.13	C3N-03430	.	.	.	.	.	.	.	.	.	8.20	D	D	D	P	N	D	L	T	N	0.283	T	T	D	0.199	0.789	0.467	1.158	T	T	T	T	D	D	3.628	25.100	0.989	D	N	0.464	4.766	0.470	4.897	1.000	0.722	0.547	0.702	0.735	.	5.350	5.350	1.504	1.176	0.676	0.818	0.998	0.998	365	Ephrin_type-A_receptor_2,_ligand_binding_domain;Ephrin_receptor_ligand_binding_domain	.	.	.	EPHA2	388	0	612	140	0.186170212765957	TRUE	TRUE
ENSG00000143631.11	.	BCM	GRCh38.p13	chr1	152309152	152309152	+	T	T	A	Missense_Mutation	SNP	ENST00000368799.2	exon3	c.A5734T	p.R1912W	exonic	ENSG00000143631.11	.	nonsynonymous SNV	ENSG00000143631.11:ENST00000368799.2:exon3:c.A5734T:p.R1912W	1q21.3	C3N-03430	.	.	.	.	.	.	.	.	.	6.18	D	.	D	D	.	N	M	T	D	0.099	T	T	T	0.040	0.368	0.365	.	T	T	T	T	D	T	1.727	17.210	0.983	N	N	-0.429	1.321	-0.770	0.801	0.000	0.554	0.574	0.574	0.621	.	3.450	-3.610	-0.666	0.841	0.321	0.000	0.001	0.002	564	.	.	.	.	FLG	802	0	1337	116	0.0798348245010324	NA	TRUE
ENSG00000163207.7	.	BCM	GRCh38.p13	chr1	152911083	152911083	+	A	A	G	Missense_Mutation	SNP	ENST00000368764.4	exon2	c.A1286G	p.Q429R	exonic	ENSG00000163207.7	.	nonsynonymous SNV	ENSG00000163207.7:ENST00000368764.4:exon2:c.A1286G:p.Q429R	1q21.3	C3N-03430	.	.	.	.	.	.	.	.	.	2.19	T	D	P	P	.	N	L	T	N	0.166	T	T	D	0.056	0.233	0.510	0.019	T	T	T	T	T	T	1.443	15.370	0.957	N	N	-0.356	1.481	-0.522	1.167	1.000	0.615	0.634	0.574	0.564	.	3.470	3.470	-2.148	0.093	0.629	0.000	0.001	0.002	792	.	.	.	ID=COSV100908206;OCCURENCE=1(large_intestine)	IVL	242	0	400	38	0.0867579908675799	TRUE	TRUE
ENSG00000162738.6	.	BCM	GRCh38.p13	chr1	160419153	160419153	+	T	T	C	Missense_Mutation	SNP	ENST00000368061.3	exon4	c.T344C	p.L115P	exonic	ENSG00000162738.6	.	nonsynonymous SNV	ENSG00000162738.6:ENST00000368061.3:exon4:c.T344C:p.L115P	1q23.2	C3N-03430	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.972	D	D	D	0.940	0.750	0.961	1.777	T	D	D	D	D	T	3.836	26.000	0.999	D	D	0.740	7.721	0.663	7.106	1.000	0.707	0.588	0.725	0.542	.	4.930	4.930	5.905	1.055	0.660	1.000	0.992	0.898	764	.	.	.	.	VANGL2	202	0	308	68	0.180851063829787	TRUE	TRUE
ENSG00000130508.11	.	BCM	GRCh38.p13	chr2	1644735	1644735	+	A	A	G	Missense_Mutation	SNP	ENST00000252804.9	exon18	c.T3626C	p.L1209P	exonic	ENSG00000130508.11	.	nonsynonymous SNV	ENSG00000130508.11:ENST00000252804.9:exon18:c.T3626C:p.L1209P	2p25.3	C3N-03430	.	.	.	.	.	.	.	.	.	8.20	T	T	P	P	N	D	L	T	N	0.783	T	T	D	0.406	0.576	0.683	1.389	T	T	D	D	D	D	3.183	23.800	0.996	D	D	0.250	3.533	0.206	3.213	1.000	0.707	0.588	0.644	0.714	.	5.420	5.420	4.039	1.251	0.756	0.983	0.271	0.402	824	Peroxidasin,_peroxidase_domain	.	.	.	PXDN	95	1	174	12	0.0645161290322581	TRUE	TRUE
ENSG00000218819.6	.	BCM	GRCh38.p13	chr2	21137606	21137606	+	C	C	G	Missense_Mutation	SNP	ENST00000405799.3	exon4	c.C139G	p.Q47E	exonic	ENSG00000218819.6	.	nonsynonymous SNV	ENSG00000218819.6:ENST00000405799.3:exon4:c.C139G:p.Q47E	2p24.1	C3N-03430	.	.	.	.	.	.	.	.	.	6.14	D	D	.	.	.	.	.	T	N	0.366	T	T	D	0.164	0.357	0.193	.	.	T	T	T	D	T	3.023	23.500	0.989	D	D	0.219	3.387	0.297	3.697	1.000	0.487	0.574	0.574	0.564	.	5.390	5.390	7.352	1.018	0.589	1.000	0.940	0.932	691	Tudor_domain	.	.	.	TDRD15	83	0	147	12	0.0754716981132075	TRUE	TRUE
ENSG00000170577.8	.	BCM	GRCh38.p13	chr2	45008827	45008827	+	G	G	A	Missense_Mutation	SNP	ENST00000303077.7	exon1	c.C284T	p.A95V	exonic	ENSG00000170577.8	.	nonsynonymous SNV	ENSG00000170577.8:ENST00000303077.7:exon1:c.C284T:p.A95V	2p21	C3N-03430	.	.	.	.	.	.	.	.	.	19.20	D	D	D	P	D	D	M	D	D	0.733	D	D	D	0.753	0.533	0.846	1.809	D	D	D	D	D	D	4.659	32	0.999	D	D	0.775	8.309	0.727	8.286	1.000	0.652	0.596	0.666	0.710	.	4.580	4.580	10.003	1.176	0.676	1.000	1.000	0.998	807	Homeobox_protein_SIX1,_N-terminal_SD_domain	.	.	ID=COSV57390105;OCCURENCE=2(large_intestine)	SIX2	362	0	642	80	0.110803324099723	TRUE	TRUE
ENSG00000135636.14	.	BCM	GRCh38.p13	chr2	71574222	71574222	+	G	G	A	Missense_Mutation	SNP	ENST00000258104.7	exon30	c.G3199A	p.E1067K	exonic	ENSG00000135636.14	.	nonsynonymous SNV	ENSG00000135636.14:ENST00000258104.7:exon30:c.G3199A:p.E1067K	2p13.2	C3N-03430	.	.	.	.	.	.	.	.	.	18.20	D	T	D	D	D	D	M	D	D	0.765	D	D	D	0.675	0.496	0.935	0.615	T	D	D	D	D	D	3.578	25.000	0.999	D	D	0.807	8.915	0.803	10.211	1.000	0.707	0.547	0.645	0.714	.	5.600	5.600	9.530	1.176	0.676	1.000	0.808	0.670	453	.	.	.	.	DYSF	218	0	394	37	0.08584686774942	TRUE	NA
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178560105	178560105	+	A	A	C	Missense_Mutation	SNP	ENST00000591111.5	exon276	c.T81104G	p.L27035R	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon276:c.T81104G:p.L27035R	2q31.2	C3N-03430	.	.	.	.	.	.	.	.	.	8.17	T	.	D	D	.	D	L	T	D	0.892	T	T	T	0.466	0.535	0.755	0.532	T	.	D	T	T	D	2.796	23.000	0.794	D	D	0.498	5.018	0.479	4.971	1.000	0.554	0.588	0.545	0.613	.	5.870	5.870	6.158	1.312	0.756	0.993	0.346	0.310	457	Fibronectin_type_III	.	.	.	TTN	127	0	200	15	0.0697674418604651	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178565278	178565278	+	C	C	T	Missense_Mutation	SNP	ENST00000591111.5	exon276	c.G75931A	p.V25311I	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon276:c.G75931A:p.V25311I	2q31.2	C3N-03430	8.294e-05	0.0001	8.667e-05	0	0	0.0001	0	0	rs371362606	0.17	T	.	B	B	.	N	N	T	N	0.082	T	T	T	0.015	.	0.072	0.069	T	.	T	T	T	T	-1.487	0.001	0.811	N	N	-1.564	0.064	-1.599	0.075	0.505	0.554	0.602	0.547	0.621	.	5.670	-7.050	-0.830	-2.627	-3.675	0.000	0.002	0.048	434	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV59868478;OCCURENCE=2(large_intestine)	TTN	189	0	331	26	0.0728291316526611	TRUE	NA
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178733476	178733476	+	T	T	C	Missense_Mutation	SNP	ENST00000591111.5	exon52	c.A14866G	p.T4956A	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon52:c.A14866G:p.T4956A	2q31.2	C3N-03430	.	.	.	.	.	.	.	.	.	6.16	T	.	D	P	.	D	.	T	D	0.251	T	T	D	0.348	0.440	0.461	0.395	T	.	T	T	T	T	3.152	23.700	0.951	D	D	0.716	7.355	0.745	8.694	1.000	0.487	0.574	0.574	0.564	.	5.860	5.860	7.985	1.138	0.665	1.000	1.000	0.996	341	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	TTN	97	0	195	21	0.0972222222222222	TRUE	TRUE
ENSG00000144406.19	.	BCM	GRCh38.p13	chr2	209793760	209793760	+	T	T	C	Missense_Mutation	SNP	ENST00000439458.5	exon7	c.T839C	p.I280T	exonic	ENSG00000144406.19	.	nonsynonymous SNV	ENSG00000144406.19:ENST00000439458.5:exon7:c.T839C:p.I280T	2q34	C3N-03430	8.237e-06	0	0	0	0	0	0	6.056e-05	rs749870075	4.20	D	D	B	B	N	N	N	T	N	0.196	T	T	T	0.015	0.212	0.158	0.400	T	T	T	T	T	D	2.051	19.650	0.985	D	N	-0.238	1.773	-0.027	2.271	0.000	0.554	0.547	0.602	0.564	.	5.110	5.110	3.506	1.138	0.660	1.000	0.997	0.996	814	.	.	.	.	UNC80	205	1	391	42	0.0969976905311778	TRUE	NA
ENSG00000178568.15	.	BCM	GRCh38.p13	chr2	211630560	211630560	+	G	G	T	Missense_Mutation	SNP	ENST00000342788.9	exon17	c.C1981A	p.L661I	exonic	ENSG00000178568.15	.	nonsynonymous SNV	ENSG00000178568.15:ENST00000342788.9:exon17:c.C1981A:p.L661I	2q34	C3N-03430	.	.	.	.	.	.	.	.	.	8.20	T	T	P	B	D	D	M	T	N	0.616	T	T	T	0.284	0.390	0.669	0.519	D	T	T	T	D	D	2.602	22.600	0.988	D	D	0.438	4.591	0.544	5.588	1.000	0.487	0.574	0.574	0.564	.	5.580	5.580	6.401	1.176	0.618	1.000	0.998	0.997	768	.	.	.	.	ERBB4	370	0	632	136	0.177083333333333	TRUE	TRUE
ENSG00000197938.5	.	BCM	GRCh38.p13	chr3	98283605	98283605	+	A	A	G	Missense_Mutation	SNP	ENST00000355273.2	exon1	c.A718G	p.R240G	exonic	ENSG00000197938.5	.	nonsynonymous SNV	ENSG00000197938.5:ENST00000355273.2:exon1:c.A718G:p.R240G	3q11.2	C3N-03430	8.265e-06	0	0	0	0	0	0	6.059e-05	rs745774293	1.20	T	T	B	B	U	N	L	T	D	0.201	T	T	T	0.022	0.353	0.353	0.020	T	T	T	T	T	T	0.868	10.100	0.828	N	N	-0.861	0.571	-0.925	0.586	0.000	0.487	0.574	0.574	0.564	.	3.030	1.790	0.327	1.174	0.665	0.000	0.796	0.569	756	GPCR,_rhodopsin-like,_7TM	.	.	.	OR5H2	199	1	447	34	0.0706860706860707	TRUE	NA
ENSG00000175093.5	.	BCM	GRCh38.p13	chr3	141066546	141066546	+	C	C	T	Missense_Mutation	SNP	ENST00000310546.3	exon2	c.C442T	p.R148C	exonic	ENSG00000175093.5	.	nonsynonymous SNV	ENSG00000175093.5:ENST00000310546.3:exon2:c.C442T:p.R148C	3q23	C3N-03430	8.518e-05	0	0	0.0010	0	0	0	0	rs374257422	12.20	D	T	D	P	D	D	M	T	D	0.459	T	T	D	0.355	.	0.772	1.584	T	T	D	T	D	D	4.339	29.900	0.999	D	D	0.644	6.407	0.613	6.392	1.000	0.696	0.590	0.723	0.542	.	5.030	4.070	5.605	1.022	0.596	1.000	1.000	0.999	687	0.000	.	.	.	SPSB4	40	0	88	15	0.145631067961165	TRUE	NA
ENSG00000172238.6	.	BCM	GRCh38.p13	chr4	93829506	93829509	+	AAGC	AAGC	-	Frame_Shift_Del	DEL	ENST00000306011.6	exon1	c.580_583del	p.K194Cfs*108	exonic	ENSG00000172238.6	.	frameshift deletion	ENSG00000172238.6:ENST00000306011.6:exon1:c.580_583del:p.K194Cfs*108	4q22.2	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATOH1	317	0	473	84	0.1508078994614	TRUE	TRUE
ENSG00000164056.11	.	BCM	GRCh38.p13	chr4	123402541	123402541	+	-	NA	ACTTT	Frame_Shift_Ins	INS	ENST00000651917.1	exon3	c.950_951insACTTT	p.P318Lfs*60	exonic	ENSG00000164056.11	.	frameshift insertion	ENSG00000164056.11:ENST00000651917.1:exon3:c.950_951insACTTT:p.P318Lfs*60	4q28.1	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPRY1	NA	NA	NA	NA	NA	NA	NA
ENSG00000196159.12	.	BCM	GRCh38.p13	chr4	125317162	125317162	+	G	G	A	Missense_Mutation	SNP	ENST00000674496.1	exon1	c.G751A	p.G251S	exonic	ENSG00000196159.12	.	nonsynonymous SNV	ENSG00000196159.12:ENST00000674496.1:exon1:c.G751A:p.G251S	4q28.1	C3N-03430	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	U	N	N	T	N	0.091	T	T	T	0.057	0.239	0.082	0.148	T	T	T	T	T	T	2.188	20.800	0.950	D	N	-0.695	0.820	-0.460	1.267	1.000	0.447	0.563	0.504	0.373	.	5.130	3.340	3.270	0.230	-0.106	1.000	0.989	0.943	932	Cadherin-like	.	.	.	FAT4	74	0	107	28	0.207407407407407	TRUE	TRUE
ENSG00000170561.13	.	BCM	GRCh38.p13	chr5	2749600	2749600	+	T	T	C	Missense_Mutation	SNP	ENST00000302057.6	exon2	c.A437G	p.E146G	exonic	ENSG00000170561.13	.	nonsynonymous SNV	ENSG00000170561.13:ENST00000302057.6:exon2:c.A437G:p.E146G	5p15.33	C3N-03430	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.919	D	D	D	0.926	0.696	0.958	2.812	D	D	D	D	D	D	4.650	32	0.999	D	D	0.864	10.165	0.775	9.433	1.000	0.767	0.574	0.851	0.639	.	4.850	4.850	7.665	1.134	0.661	1.000	1.000	1.000	946	Homeobox_KN_domain;Homeobox_domain	.	.	.	IRX2	536	0	877	75	0.078781512605042	TRUE	TRUE
ENSG00000037749.12	.	BCM	GRCh38.p13	chr5	154049822	154049822	+	G	G	A	Missense_Mutation	SNP	ENST00000322602.9	exon2	c.G100A	p.E34K	exonic	ENSG00000037749.12	.	nonsynonymous SNV	ENSG00000037749.12:ENST00000322602.9:exon2:c.G100A:p.E34K	5q33.2	C3N-03430	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.119	T	T	T	0.062	0.438	0.442	.	T	T	T	T	T	T	1.685	16.930	0.991	D	N	-0.440	1.298	-0.307	1.549	1.000	0.737	0.616	0.733	0.711	.	6.020	5.150	4.038	1.176	0.676	0.870	0.894	0.836	835	.	.	.	.	MFAP3	275	0	571	40	0.0654664484451719	TRUE	TRUE
ENSG00000113262.16	.	BCM	GRCh38.p13	chr5	178989061	178989061	+	C	C	T	Missense_Mutation	SNP	ENST00000517717.3	exon7	c.G1228A	p.A410T	exonic	ENSG00000113262.16	.	nonsynonymous SNV	ENSG00000113262.16:ENST00000517717.3:exon7:c.G1228A:p.A410T	5q35.3	C3N-03430	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	.	D	M	D	D	0.933	D	D	D	0.800	0.707	0.931	0.366	T	D	D	D	D	D	4.013	27.100	0.999	D	D	0.790	8.594	0.725	8.239	1.000	0.487	0.574	0.547	0.613	.	5.220	5.220	7.798	0.962	0.524	1.000	0.775	0.483	720	Receptor,_ligand_binding_region	.	.	.	GRM6	606	0	1091	110	0.0915903413821815	TRUE	TRUE
ENSG00000156564.9	.	BCM	GRCh38.p13	chr6	40432957	40432957	+	G	G	A	Missense_Mutation	SNP	ENST00000338305.7	exon2	c.C157T	p.R53W	exonic	ENSG00000156564.9	.	nonsynonymous SNV	ENSG00000156564.9:ENST00000338305.7:exon2:c.C157T:p.R53W	6p21.2	C3N-03430	0.0001	0	0	0	0.0002	0.0002	0	0	rs367755986	12.20	D	D	D	D	D	D	L	T	D	0.651	T	T	T	0.332	.	0.650	1.101	D	D	T	T	T	D	3.193	23.800	0.999	D	D	0.228	3.428	0.125	2.838	0.074	0.554	0.574	0.602	0.564	.	5.760	1.710	0.294	0.161	0.676	0.969	0.998	0.976	946	.	.	.	ID=COSV57825758;OCCURENCE=3(pancreas)	LRFN2	103	0	190	33	0.147982062780269	TRUE	TRUE
ENSG00000172469.16	.	BCM	GRCh38.p13	chr6	95605978	95605978	+	A	A	G	Missense_Mutation	SNP	ENST00000358812.9	exon5	c.A962G	p.Y321C	exonic	ENSG00000172469.16	.	nonsynonymous SNV	ENSG00000172469.16:ENST00000358812.9:exon5:c.A962G:p.Y321C	6q16.1	C3N-03430	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.908	D	D	D	0.906	0.911	0.990	0.324	D	T	D	D	D	D	4.199	28.600	0.998	D	D	0.980	13.298	0.945	15.807	1.000	0.707	0.725	0.659	0.564	.	6.170	6.170	8.836	1.311	0.756	1.000	1.000	1.000	912	.	.	.	.	MANEA	136	0	222	29	0.115537848605578	TRUE	TRUE
ENSG00000122566.21	.	BCM	GRCh38.p13	chr7	26193347	26193347	+	C	C	G	Missense_Mutation	SNP	ENST00000354667.8	exon10	c.G904C	p.D302H	exonic	ENSG00000122566.21	.	nonsynonymous SNV	ENSG00000122566.21:ENST00000354667.8:exon10:c.G904C:p.D302H	7p15.2	C3N-03430	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.756	D	D	D	0.635	0.270	0.898	2.464	D	D	D	D	D	D	3.882	26.200	0.988	D	D	0.620	6.137	0.652	6.947	1.000	0.722	0.686	0.702	0.735	.	5.750	5.750	4.878	1.008	0.599	1.000	1.000	0.998	699	.	.	.	.	HNRNPA2B1	98	0	200	18	0.0825688073394495	TRUE	TRUE
ENSG00000106571.14	.	BCM	GRCh38.p13	chr7	42148279	42148279	+	C	C	T	Missense_Mutation	SNP	ENST00000395925.8	exon3	c.G314A	p.R105H	exonic	ENSG00000106571.14	.	nonsynonymous SNV	ENSG00000106571.14:ENST00000395925.8:exon3:c.G314A:p.R105H	7p14.1	C3N-03430	2.785e-05	0	9.636e-05	0	0	0	0	0.0001	rs750890677	12.20	D	D	D	D	D	D	L	T	N	0.793	T	T	D	0.319	0.306	0.705	0.688	T	T	T	D	D	D	3.572	24.900	1.000	D	D	0.618	6.115	0.627	6.581	1.000	0.706	0.574	0.710	0.636	.	5.830	5.830	7.542	1.025	0.599	1.000	0.477	0.253	916	.	.	.	ID=COSV67889940;OCCURENCE=1(large_intestine),1(stomach),1(haematopoietic_and_lymphoid_tissue),1(upper_aerodigestive_tract)	GLI3	226	0	450	46	0.092741935483871	TRUE	TRUE
ENSG00000244219.7	.	BCM	GRCh38.p13	chr7	99607712	99607712	+	A	A	G	Missense_Mutation	SNP	ENST00000431679.6	exon5	c.A395G	p.E132G	exonic	ENSG00000244219.7	.	nonsynonymous SNV	ENSG00000244219.7:ENST00000431679.6:exon5:c.A395G:p.E132G	7q22.1	C3N-03430	.	.	.	.	.	.	.	.	.	1.2	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	2.852	23.100	0.714	D	.	.	.	.	.	0.979	0.081	0.085	0.121	0.106	0.132	3.400	2.210	2.426	1.118	0.756	1.000	0.988	0.899	146	.	.	.	.	TMEM225B	189	2	336	96	0.222222222222222	TRUE	NA
ENSG00000106278.12	.	BCM	GRCh38.p13	chr7	121972671	121972671	+	A	A	C	Missense_Mutation	SNP	ENST00000393386.7	exon4	c.A435C	p.E145D	exonic	ENSG00000106278.12	.	nonsynonymous SNV	ENSG00000106278.12:ENST00000393386.7:exon4:c.A435C:p.E145D	7q31.32	C3N-03430	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	N	T	N	0.415	T	T	D	0.085	0.335	0.187	0.463	T	T	T	T	D	D	2.091	19.950	0.993	D	N	-0.228	1.800	0.031	2.470	0.715	0.706	0.574	0.710	0.564	.	5.720	5.720	3.150	1.312	0.756	1.000	1.000	1.000	644	Alpha_carbonic_anhydrase_domain	.	.	.	PTPRZ1	96	0	214	18	0.0775862068965517	TRUE	TRUE
ENSG00000147724.12	.	BCM	GRCh38.p13	chr8	138151379	138151379	+	G	G	T	Missense_Mutation	SNP	ENST00000395297.6	exon13	c.C3096A	p.N1032K	exonic	ENSG00000147724.12	.	nonsynonymous SNV	ENSG00000147724.12:ENST00000395297.6:exon13:c.C3096A:p.N1032K	8q24.23	C3N-03430	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.648	T	T	D	0.141	0.329	0.103	0.325	T	T	T	T	D	D	3.268	24.000	0.996	D	D	0.232	3.447	0.070	2.614	0.000	0.487	0.574	0.574	0.564	.	5.330	2.130	2.828	1.176	0.676	1.000	0.913	0.854	956	.	.	.	.	FAM135B	96	0	157	18	0.102857142857143	TRUE	TRUE
ENSG00000108021.20	.	BCM	GRCh38.p13	chr10	5747398	5747398	+	C	C	T	Missense_Mutation	SNP	ENST00000328090.9	exon15	c.C3977T	p.P1326L	exonic	ENSG00000108021.20	.	nonsynonymous SNV	ENSG00000108021.20:ENST00000328090.9:exon15:c.C3977T:p.P1326L	10p15.1	C3N-03430	1.658e-05	0	8.646e-05	0	0	1.5e-05	0	0	rs564549297	3.20	T	D	P	B	N	N	M	T	D	0.295	T	T	T	0.161	0.283	0.134	0.084	T	T	T	T	T	T	1.139	13.130	0.979	N	N	-0.179	1.937	-0.270	1.628	1.000	0.707	0.725	0.702	0.714	.	5.550	4.640	1.660	1.026	0.549	0.003	0.173	0.006	548	.	.	.	.	TASOR2	210	0	308	153	0.331887201735358	TRUE	NA
ENSG00000187522.16	.	BCM	GRCh38.p13	chr10	14839905	14839905	+	G	G	A	Missense_Mutation	SNP	ENST00000378372.8	exon2	c.G58A	p.D20N	exonic	ENSG00000187522.16	.	nonsynonymous SNV	ENSG00000187522.16:ENST00000378372.8:exon2:c.G58A:p.D20N	10p13	C3N-03430	.	.	.	.	.	.	.	.	.	10.20	T	D	D	D	D	D	N	T	N	0.480	T	T	D	0.249	0.426	0.482	0.933	T	T	T	T	D	D	5.180	33	0.997	D	D	0.637	6.323	0.710	7.935	1.000	0.722	0.686	0.699	0.639	.	5.610	5.610	7.146	1.176	0.676	1.000	0.989	0.952	840	.	.	.	.	HSPA14	198	0	320	185	0.366336633663366	TRUE	TRUE
ENSG00000260314.3	.	BCM	GRCh38.p13	chr10	17866642	17866642	+	A	A	C	Missense_Mutation	SNP	ENST00000569591.3	exon12	c.A1864C	p.K622Q	exonic	ENSG00000260314.3	.	nonsynonymous SNV	ENSG00000260314.3:ENST00000569591.3:exon12:c.A1864C:p.K622Q	10p12.33	C3N-03430	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	U	D	M	T	D	0.371	T	T	T	0.250	0.606	0.502	.	T	T	T	T	D	D	4.092	27.700	0.995	D	D	0.363	4.125	0.361	4.094	0.001	0.487	0.574	0.574	0.564	.	4.250	4.250	8.947	1.302	0.756	1.000	0.998	0.974	900	C-type_lectin-like	.	.	.	MRC1	489	2	908	80	0.0809716599190283	TRUE	TRUE
ENSG00000225830.14	.	BCM	GRCh38.p13	chr10	49524090	49524090	+	C	C	G	Missense_Mutation	SNP	ENST00000355832.10	exon5	c.G1340C	p.R447P	exonic	ENSG00000225830.14	.	nonsynonymous SNV	ENSG00000225830.14:ENST00000355832.10:exon5:c.G1340C:p.R447P	10q11.23	C3N-03430	.	.	.	.	.	.	.	.	.	8.19	D	D	B	B	.	D	M	D	N	0.282	T	T	D	0.078	0.413	0.603	0.545	T	T	T	T	D	T	2.591	22.600	0.995	D	N	-0.349	1.498	-0.279	1.608	1.000	0.707	0.725	0.659	0.714	.	6.020	4.080	3.666	0.130	-0.176	0.995	0.021	0.731	707	.	.	.	.	ERCC6	230	0	490	36	0.0684410646387833	NA	TRUE
ENSG00000138336.9	.	BCM	GRCh38.p13	chr10	68645587	68645587	+	T	T	C	Missense_Mutation	SNP	ENST00000373644.5	exon4	c.T2858C	p.L953P	exonic	ENSG00000138336.9	.	nonsynonymous SNV	ENSG00000138336.9:ENST00000373644.5:exon4:c.T2858C:p.L953P	10q21.3	C3N-03430	.	.	.	.	.	.	.	.	.	4.20	D	D	B	B	N	N	M	T	N	0.300	T	T	T	0.042	0.155	0.043	0.081	T	T	T	T	D	T	1.362	14.830	0.996	N	N	-0.812	0.637	-0.840	0.702	0.005	0.672	0.588	0.702	0.621	.	5.310	1.590	1.403	1.138	0.665	0.008	0.118	0.183	645	.	.	.	.	TET1	148	0	271	33	0.108552631578947	TRUE	TRUE
ENSG00000107518.18	.	BCM	GRCh38.p13	chr10	115300059	115300059	+	G	G	A	Missense_Mutation	SNP	ENST00000355044.8	exon16	c.G2441A	p.R814H	exonic	ENSG00000107518.18	.	nonsynonymous SNV	ENSG00000107518.18:ENST00000355044.8:exon16:c.G2441A:p.R814H	10q25.3	C3N-03430	4.947e-05	0	0	0.0001	0.0003	3e-05	0	6.066e-05	rs781892443	8.20	T	T	D	D	D	D	L	T	N	0.822	T	T	T	0.376	.	0.430	0.939	D	T	T	T	T	D	3.929	26.500	0.999	D	D	0.857	9.998	0.879	12.865	1.000	0.638	0.588	0.653	0.564	.	5.760	5.760	10.003	1.176	0.676	1.000	1.000	0.996	848	C-type_lectin-like;Attractin-like,_C-type_lectin-like_domain	.	.	ID=COSV58075293;OCCURENCE=4(large_intestine),1(ovary),1(haematopoietic_and_lymphoid_tissue),2(stomach),1(pancreas),2(lung)	ATRNL1	129	1	175	50	0.222222222222222	TRUE	TRUE
ENSG00000182070.5	.	BCM	GRCh38.p13	chr11	5151933	5151933	+	A	A	C	Missense_Mutation	SNP	ENST00000380367.2	exon2	c.T437G	p.I146R	exonic	ENSG00000182070.5	.	nonsynonymous SNV	ENSG00000182070.5:ENST00000380367.2:exon2:c.T437G:p.I146R	11p15.4	C3N-03430	.	.	.	.	.	.	.	.	.	7.20	D	D	B	B	N	N	H	T	D	0.613	T	T	T	0.265	0.813	0.421	0.044	T	T	T	T	D	T	1.930	18.720	0.964	D	D	0.011	2.549	-0.021	2.289	1.000	0.615	0.574	0.659	0.564	.	5.280	5.280	2.481	0.315	0.691	0.179	0.003	0.094	834	GPCR,_rhodopsin-like,_7TM	.	.	.	OR52A1	192	0	366	37	0.0918114143920596	TRUE	TRUE
ENSG00000149050.10	.	BCM	GRCh38.p13	chr11	7000937	7000937	+	C	C	T	Missense_Mutation	SNP	ENST00000278314.5	exon3	c.G746A	p.C249Y	exonic	ENSG00000149050.10	.	nonsynonymous SNV	ENSG00000149050.10:ENST00000278314.5:exon3:c.G746A:p.C249Y	11p15.4	C3N-03430	.	.	.	.	.	.	.	.	.	6.20	D	D	B	B	N	N	H	T	D	0.279	T	T	T	0.147	0.813	0.367	0.029	T	T	T	T	D	T	0.370	5.086	0.636	D	N	-0.518	1.141	-0.649	0.973	0.889	0.638	0.574	0.653	0.568	.	3.750	0.312	1.358	0.038	-0.182	0.006	0.003	0.003	809	Zinc_finger_C2H2-type	.	.	.	ZNF214	159	0	276	18	0.0612244897959184	TRUE	TRUE
ENSG00000176200.1	.	BCM	GRCh38.p13	chr11	59503891	59503891	+	C	C	A	Missense_Mutation	SNP	ENST00000313253.1	exon1	c.C316A	p.L106I	exonic	ENSG00000176200.1	.	nonsynonymous SNV	ENSG00000176200.1:ENST00000313253.1:exon1:c.C316A:p.L106I	11q12.1	C3N-03430	.	.	.	.	.	.	.	.	.	1.20	D	T	P	P	N	N	L	T	N	0.114	T	T	T	0.061	0.382	0.262	0.035	T	T	T	T	T	T	1.635	16.600	0.991	N	N	-0.186	1.916	-0.186	1.821	0.190	0.428	0.469	0.547	0.613	.	5.440	3.580	-2.633	0.127	0.526	0.000	0.025	0.986	308	GPCR,_rhodopsin-like,_7TM	.	.	.	OR4D11	234	0	460	45	0.0891089108910891	TRUE	TRUE
ENSG00000110046.13	.	BCM	GRCh38.p13	chr11	64914159	64914159	+	G	G	A	Missense_Mutation	SNP	ENST00000377264.8	exon3	c.C409T	p.R137W	exonic	ENSG00000110046.13	.	nonsynonymous SNV	ENSG00000110046.13:ENST00000377264.8:exon3:c.C409T:p.R137W	11q13.1	C3N-03430	9.971e-05	0	0	0	0	0.0001	0	0.0001	rs756230306	11.20	D	D	D	P	D	D	L	T	D	0.304	T	T	D	0.174	0.324	0.264	1.345	T	T	T	T	D	D	3.457	24.600	0.999	D	D	0.439	4.592	0.430	4.578	1.000	0.696	0.611	0.723	0.636	.	4.220	4.220	4.046	0.221	-0.111	1.000	0.011	0.074	300	.	.	.	.	ATG2A	219	0	347	30	0.0795755968169761	TRUE	NA
ENSG00000175550.8	.	BCM	GRCh38.p13	chr11	65919795	65919795	+	A	A	C	Missense_Mutation	SNP	ENST00000312515.7	exon2	c.A58C	p.I20L	exonic	ENSG00000175550.8	.	nonsynonymous SNV	ENSG00000175550.8:ENST00000312515.7:exon2:c.A58C:p.I20L	11q13.1	C3N-03430	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	N	D	M	T	N	0.705	T	T	D	0.463	0.785	0.757	2.476	D	T	D	T	D	D	4.346	29.900	0.993	D	D	0.649	6.460	0.564	5.797	1.000	0.733	0.522	0.594	0.622	.	3.860	3.860	3.206	1.294	0.740	1.000	1.000	1.000	232	Transcription_factor_CBF/NF-Y/archaeal_histone_domain	.	.	.	DRAP1	376	0	649	142	0.179519595448799	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3N-03430	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	247	0	493	189	0.277126099706745	TRUE	TRUE
ENSG00000167528.12	.	BCM	GRCh38.p13	chr12	48343367	48343367	+	A	A	T	Missense_Mutation	SNP	ENST00000544117.6	exon6	c.T923A	p.I308N	exonic	ENSG00000167528.12	.	nonsynonymous SNV	ENSG00000167528.12:ENST00000544117.6:exon6:c.T923A:p.I308N	12q13.11	C3N-03430	.	.	.	.	.	.	.	.	.	5.20	D	D	B	B	N	N	N	T	D	0.439	T	T	T	0.074	0.395	0.267	0.808	T	T	T	T	D	D	2.683	22.800	0.992	N	N	-0.250	1.742	-0.140	1.938	0.989	0.615	0.577	0.659	0.636	.	5.670	4.510	-0.106	1.312	0.756	0.000	0.991	0.994	551	Zinc_finger_C2H2-type	.	.	.	ZNF641	390	1	631	137	0.178385416666667	TRUE	TRUE
ENSG00000197651.4	.	BCM	GRCh38.p13	chr12	90953591	90953591	+	T	T	A	Missense_Mutation	SNP	ENST00000358859.3	exon1	c.A1152T	p.L384F	exonic	ENSG00000197651.4	.	nonsynonymous SNV	ENSG00000197651.4:ENST00000358859.3:exon1:c.A1152T:p.L384F	12q21.33	C3N-03430	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.067	T	T	T	0.032	0.256	0.088	0.313	T	T	T	T	T	T	1.278	14.220	0.877	N	N	-0.616	0.959	-0.566	1.098	0.000	0.487	0.574	0.547	0.564	.	5.410	0.241	0.460	1.138	0.609	0.990	0.029	0.029	922	.	.	.	.	CCER1	159	1	314	31	0.0898550724637681	TRUE	TRUE
ENSG00000173064.13	.	BCM	GRCh38.p13	chr12	112184442	112184443	+	AG	AG	-	Frame_Shift_Del	DEL	ENST00000377560.9	exon61	c.10517_10518del	p.S3506Cfs*93	exonic	ENSG00000173064.13	.	frameshift deletion	ENSG00000173064.13:ENST00000377560.9:exon61:c.10517_10518del:p.S3506Cfs*93	12q24.13	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HECTD4	152	0	236	56	0.191780821917808	TRUE	TRUE
ENSG00000121742.19	.	BCM	GRCh38.p13	chr13	20223428	20223428	+	G	G	T	Missense_Mutation	SNP	ENST00000647029.1	exon5	c.C53A	p.T18N	exonic	ENSG00000121742.19	.	nonsynonymous SNV	ENSG00000121742.19:ENST00000647029.1:exon5:c.C53A:p.T18N	13q12.11	C3N-03430	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.960	D	D	D	0.941	0.830	0.969	0.531	T	D	D	D	D	D	3.927	26.500	0.994	D	D	1.026	14.750	0.958	16.483	1.000	0.487	0.590	0.574	0.542	.	5.380	5.380	9.940	1.176	0.676	1.000	1.000	0.990	589	Connexin,_N-terminal	.	.	.	GJB6	535	0	996	95	0.0870760769935839	TRUE	TRUE
ENSG00000176435.7	.	BCM	GRCh38.p13	chr14	38255896	38255896	+	C	C	T	Missense_Mutation	SNP	ENST00000342213.3	exon1	c.G127A	p.A43T	exonic	ENSG00000176435.7	.	nonsynonymous SNV	ENSG00000176435.7:ENST00000342213.3:exon1:c.G127A:p.A43T	14q21.1	C3N-03430	.	.	.	.	.	.	.	.	.	5.20	T	D	D	P	N	N	L	T	N	0.318	T	T	D	0.087	0.370	0.654	1.543	T	T	T	T	D	T	3.610	25.100	0.999	D	N	-0.037	2.382	-0.029	2.264	1.000	0.487	0.574	0.607	0.562	.	3.960	2.030	1.284	1.026	0.549	0.995	0.997	0.984	805	C-type_lectin-like	.	.	.	CLEC14A	394	0	643	49	0.0708092485549133	TRUE	TRUE
ENSG00000211899.10	.	BCM	GRCh38.p13	chr14	105856185	105856185	+	C	C	T	Missense_Mutation	SNP	ENST00000637539.2	exon1	c.G34A	p.V12I	exonic	ENSG00000211899.10	.	nonsynonymous SNV	ENSG00000211899.10:ENST00000637539.2:exon1:c.G34A:p.V12I	14q32.33	C3N-03430	3.773e-05	0	0.0003	0	0	0	0	9.925e-05	rs781905207	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHM	211	1	287	57	0.165697674418605	TRUE	NA
ENSG00000137815.14	.	BCM	GRCh38.p13	chr15	41438348	41438348	+	C	C	T	Missense_Mutation	SNP	ENST00000389629.8	exon2	c.C226T	p.R76C	exonic	ENSG00000137815.14	.	nonsynonymous SNV	ENSG00000137815.14:ENST00000389629.8:exon2:c.C226T:p.R76C	15q15.1	C3N-03430	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	U	D	L	.	D	0.583	T	T	T	0.176	0.270	0.620	2.166	D	T	D	D	D	D	3.977	26.800	0.999	D	N	0.392	4.295	0.344	3.984	1.000	0.732	0.725	0.744	0.714	.	5.100	3.070	1.643	1.026	0.599	1.000	1.000	0.997	201	.	.	.	.	RTF1	162	0	283	24	0.0781758957654723	TRUE	TRUE
ENSG00000174197.16	.	BCM	GRCh38.p13	chr15	41696971	41696971	+	A	A	C	Missense_Mutation	SNP	ENST00000219905.11	exon3	c.A1961C	p.K654T	exonic	ENSG00000174197.16	.	nonsynonymous SNV	ENSG00000174197.16:ENST00000219905.11:exon3:c.A1961C:p.K654T	15q15.1	C3N-03430	.	.	.	.	.	.	.	.	.	10.18	D	D	.	.	N	D	L	T	D	0.701	T	T	D	0.295	0.187	0.235	0.529	T	T	D	T	D	D	3.773	25.700	0.998	D	D	0.533	5.307	0.561	5.766	1.000	0.719	0.654	0.725	0.734	.	5.210	5.210	6.786	1.312	0.756	1.000	0.997	0.993	127	.	.	.	.	MGA	74	0	129	12	0.0851063829787234	TRUE	TRUE
ENSG00000166147.14	.	BCM	GRCh38.p13	chr15	48644705	48644705	+	C	C	T	Missense_Mutation	SNP	ENST00000316623.10	exon2	c.G65A	p.S22N	exonic	ENSG00000166147.14	.	nonsynonymous SNV	ENSG00000166147.14:ENST00000316623.10:exon2:c.G65A:p.S22N	15q21.1	C3N-03430	.	.	.	.	.	.	.	.	.	7.17	D	T	.	.	N	N	.	D	D	0.496	T	T	D	0.157	0.498	0.666	0.515	T	T	T	T	D	T	3.024	23.500	0.960	D	D	0.072	2.777	0.208	3.224	1.000	0.564	0.484	0.504	0.562	.	4.610	4.610	3.892	1.018	0.549	1.000	1.000	0.994	584	.	.	.	.	FBN1	473	1	866	75	0.079702444208289	TRUE	TRUE
ENSG00000074603.19	.	BCM	GRCh38.p13	chr15	65480265	65480265	+	G	G	A	Missense_Mutation	SNP	ENST00000341861.9	exon10	c.C1301T	p.T434M	exonic	ENSG00000074603.19	.	nonsynonymous SNV	ENSG00000074603.19:ENST00000341861.9:exon10:c.C1301T:p.T434M	15q22.31	C3N-03430	.	.	.	.	.	.	.	.	rs758585687	9.20	D	T	D	D	D	D	L	T	N	0.655	T	T	T	0.139	0.390	0.082	0.642	T	T	T	T	D	D	2.783	23.000	0.999	D	D	0.565	5.588	0.628	6.595	0.994	0.732	0.744	0.609	0.714	.	5.670	5.670	6.184	1.176	0.676	1.000	0.998	0.994	456	Dipeptidylpeptidase_IV,_N-terminal_domain	.	.	.	DPP8	179	0	340	35	0.0933333333333333	TRUE	NA
ENSG00000156218.13	.	BCM	GRCh38.p13	chr15	83988797	83988797	+	A	A	G	Missense_Mutation	SNP	ENST00000286744.10	exon22	c.A3823G	p.S1275G	exonic	ENSG00000156218.13	.	nonsynonymous SNV	ENSG00000156218.13:ENST00000286744.10:exon22:c.A3823G:p.S1275G	15q25.2	C3N-03430	.	.	.	.	.	.	.	.	.	7.20	D	D	D	P	N	N	M	T	N	0.317	T	T	D	0.215	0.372	0.826	0.217	T	T	T	T	D	T	3.104	23.600	0.996	D	N	0.138	3.039	0.063	2.588	0.329	0.554	0.588	0.618	0.564	.	4.830	3.710	2.121	1.312	0.756	0.992	0.992	0.984	621	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	ADAMTSL3	115	0	184	11	0.0564102564102564	TRUE	NA
ENSG00000140675.13	.	BCM	GRCh38.p13	chr16	31487625	31487625	+	A	A	T	Missense_Mutation	SNP	ENST00000330498.4	exon7	c.A751T	p.I251F	exonic	ENSG00000140675.13	.	nonsynonymous SNV	ENSG00000140675.13:ENST00000330498.4:exon7:c.A751T:p.I251F	16p11.2	C3N-03430	.	.	.	.	.	.	.	.	.	9.20	T	T	B	B	D	D	L	D	N	0.604	T	T	D	0.534	0.421	0.912	0.382	T	T	D	D	D	T	2.634	22.700	0.962	D	D	-0.208	1.855	-0.071	2.132	1.000	0.455	0.492	0.504	0.568	.	4.140	4.140	4.091	1.302	0.756	1.000	1.000	0.992	308	.	.	.	.	SLC5A2	544	0	977	89	0.0834896810506567	TRUE	TRUE
ENSG00000141052.17	.	BCM	GRCh38.p13	chr17	12739285	12739285	+	T	T	G	Missense_Mutation	SNP	ENST00000343344.8	exon7	c.T674G	p.L225R	exonic	ENSG00000141052.17	.	nonsynonymous SNV	ENSG00000141052.17:ENST00000343344.8:exon7:c.T674G:p.L225R	17p12	C3N-03430	1.667e-05	0	0	0.0001	0	1.511e-05	0	0	rs763274360	1.20	D	T	B	B	N	N	L	T	N	0.492	T	T	T	0.128	0.175	0.522	0.119	T	T	T	T	T	T	1.118	12.950	0.749	N	N	-0.902	0.518	-0.898	0.623	0.000	0.581	0.574	0.565	0.564	.	4.190	1.780	0.448	1.138	0.609	0.002	0.202	0.724	948	.	.	.	ID=COSV58502009;OCCURENCE=1(liver)	MYOCD	80	0	127	11	0.0797101449275362	TRUE	TRUE
ENSG00000108797.12	.	BCM	GRCh38.p13	chr17	42688921	42688921	+	C	C	T	Missense_Mutation	SNP	ENST00000264638.9	exon10	c.C1502T	p.T501M	exonic	ENSG00000108797.12	.	nonsynonymous SNV	ENSG00000108797.12:ENST00000264638.9:exon10:c.C1502T:p.T501M	17q21.2	C3N-03430	.	.	.	.	.	.	.	.	rs148181656	9.20	T	D	P	B	D	D	L	T	N	0.530	T	T	D	0.403	.	0.680	0.576	T	T	D	D	D	D	2.608	22.700	0.982	D	N	-0.070	2.271	0.044	2.516	0.992	0.706	0.702	0.710	0.563	.	4.730	4.730	4.176	1.026	0.599	0.999	0.998	0.997	268	Laminin_G_domain	.	.	.	CNTNAP1	300	0	435	82	0.158607350096712	TRUE	NA
ENSG00000168502.17	.	BCM	GRCh38.p13	chr18	8825546	8825546	+	-	NA	GTC	In_Frame_Ins	INS	ENST00000306329.15	exon13	c.4993_4994insGTC	p.C1665_L1666insR	exonic	ENSG00000168502.17	.	nonframeshift insertion	ENSG00000168502.17:ENST00000306329.15:exon13:c.4993_4994insGTC:p.C1665_L1666insR	18p11.22	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MTCL1	NA	NA	NA	NA	NA	NA	NA
ENSG00000181626.12	.	BCM	GRCh38.p13	chr18	12115415	12115415	+	C	C	T	Missense_Mutation	SNP	ENST00000587848.3	exon10	c.C1121T	p.T374M	exonic	ENSG00000181626.12	.	nonsynonymous SNV	ENSG00000181626.12:ENST00000587848.3:exon10:c.C1121T:p.T374M	18p11.21	C3N-03430	.	.	.	.	.	.	.	.	rs192217310	0.16	.	T	B	B	.	N	N	.	.	0.025	T	T	T	0.028	.	0.030	0.410	T	T	T	T	T	T	-0.796	0.026	0.730	N	N	-2.238	0.003	-2.290	0.003	0.465	0.497	0.590	0.547	0.530	.	1.820	-3.640	-0.618	-4.951	-2.704	0.000	0.000	0.001	923	.	.	.	ID=COSV58411732;OCCURENCE=1(large_intestine)	ANKRD62	63	0	117	11	0.0859375	TRUE	TRUE
ENSG00000186300.12	.	BCM	GRCh38.p13	chr19	2852426	2852426	+	G	G	T	Nonsense_Mutation	SNP	ENST00000334241.9	exon4	c.G361T	p.G121X	exonic	ENSG00000186300.12	.	stopgain	ENSG00000186300.12:ENST00000334241.9:exon4:c.G361T:p.G121X	19p13.3	C3N-03430	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	D	.	.	.	0.032	.	.	.	.	.	.	.	.	.	D	D	.	.	4.833	33	0.987	N	N	0.193	3.274	-0.197	1.793	0.008	0.372	0.546	0.464	0.492	.	3.620	1.440	0.806	0.905	0.666	0.005	0.043	0.037	994	.	.	.	.	ZNF555	320	0	484	77	0.137254901960784	TRUE	TRUE
ENSG00000125730.17	.	BCM	GRCh38.p13	chr19	6690652	6690652	+	C	C	T	Missense_Mutation	SNP	ENST00000245907.11	exon27	c.G3466A	p.D1156N	exonic	ENSG00000125730.17	.	nonsynonymous SNV	ENSG00000125730.17:ENST00000245907.11:exon27:c.G3466A:p.D1156N	19p13.3	C3N-03430	.	.	.	.	.	.	.	.	.	3.20	T	D	B	B	U	N	M	T	N	0.278	T	T	D	0.642	0.442	0.571	0.589	T	T	T	T	T	T	2.420	22.200	0.996	N	N	-0.503	1.170	-0.502	1.199	0.468	0.706	0.547	0.710	0.621	.	5.690	4.650	0.598	1.026	0.549	0.001	0.095	0.594	889	Alpha-macroglobulin_complement_component	.	.	.	C3	434	0	711	83	0.104534005037783	TRUE	TRUE
ENSG00000130477.15	.	BCM	GRCh38.p13	chr19	17641532	17641532	+	C	C	T	Missense_Mutation	SNP	ENST00000519716.6	exon21	c.G2497A	p.V833M	exonic	ENSG00000130477.15	.	nonsynonymous SNV	ENSG00000130477.15:ENST00000519716.6:exon21:c.G2497A:p.V833M	19p13.11	C3N-03430	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	U	N	L	D	N	0.323	T	T	T	0.144	0.400	0.606	1.410	T	T	T	T	T	D	1.781	17.590	0.970	N	N	-0.981	0.425	-1.089	0.387	0.006	0.672	0.588	0.702	0.613	.	3.000	-2.630	0.024	0.763	0.463	0.000	0.992	0.593	929	.	.	.	ID=COSV53208124;OCCURENCE=1(breast),1(stomach)	UNC13A	188	0	331	43	0.114973262032086	TRUE	TRUE
ENSG00000064607.17	.	BCM	GRCh38.p13	chr19	19026220	19026220	+	A	A	C	Nonsense_Mutation	SNP	ENST00000452918.7	exon3	c.T128G	p.L43X	exonic	ENSG00000064607.17	.	stopgain	ENSG00000064607.17:ENST00000452918.7:exon3:c.T128G:p.L43X	19p13.11	C3N-03430	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.085	.	.	.	.	.	.	.	.	.	D	D	.	.	6.824	36	0.985	D	N	0.824	9.267	0.645	6.840	0.988	0.719	0.723	0.725	0.714	.	5.330	4.100	3.593	1.207	0.691	0.995	0.985	0.996	900	.	.	.	.	SUGP2	66	0	88	7	0.0736842105263158	TRUE	TRUE
ENSG00000167232.14	.	BCM	GRCh38.p13	chr19	23362579	23362579	+	C	C	A	Missense_Mutation	SNP	ENST00000300619.12	exon4	c.G400T	p.V134L	exonic	ENSG00000167232.14	.	nonsynonymous SNV	ENSG00000167232.14:ENST00000300619.12:exon4:c.G400T:p.V134L	19p12	C3N-03430	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	L	T	N	0.035	T	T	T	0.006	0.312	0.196	0.317	T	T	T	T	T	T	-0.008	1.285	0.380	N	N	-1.156	0.259	-1.325	0.193	0.000	0.732	0.744	0.651	0.492	.	0.987	-1.970	-1.605	0.345	0.282	0.000	0.001	0.001	988	.	.	.	.	ZNF91	81	0	142	11	0.0718954248366013	NA	TRUE
ENSG00000090006.18	.	BCM	GRCh38.p13	chr19	40625983	40625983	+	G	G	C	Missense_Mutation	SNP	ENST00000308370.11	exon30	c.G4160C	p.C1387S	exonic	ENSG00000090006.18	.	nonsynonymous SNV	ENSG00000090006.18:ENST00000308370.11:exon30:c.G4160C:p.C1387S	19q13.2	C3N-03430	.	.	.	.	.	.	.	.	.	16.17	.	D	D	D	U	D	.	D	.	0.920	D	D	D	0.858	0.970	0.840	1.232	D	D	D	D	D	D	4.271	29.300	0.996	D	D	0.654	6.525	0.626	6.571	1.000	0.706	0.644	0.644	0.613	.	4.470	4.470	9.942	1.176	0.676	1.000	0.901	0.892	749	TB_domain	.	.	.	LTBP4	327	0	500	129	0.205087440381558	TRUE	TRUE
ENSG00000268964.3	.	BCM	GRCh38.p13	chr19	53050525	53050525	+	A	A	T	Missense_Mutation	SNP	ENST00000601417.3	exon2	c.A1274T	p.D425V	exonic	ENSG00000268964.3	.	nonsynonymous SNV	ENSG00000268964.3:ENST00000601417.3:exon2:c.A1274T:p.D425V	19q13.41	C3N-03430	.	.	.	.	.	.	.	.	.	1.11	.	D	.	.	.	.	L	T	.	0.293	.	.	T	.	.	0.306	.	T	T	T	T	.	T	2.007	19.310	0.502	N	N	.	.	.	.	0.000	0.487	0.574	0.547	0.564	.	0.418	-0.692	0.347	0.490	0.413	0.059	0.004	0.011	994	.	.	.	.	ERVV-2	203	0	382	34	0.0817307692307692	NA	TRUE
ENSG00000152454.4	.	BCM	GRCh38.p13	chr19	57942600	57942600	+	A	A	G	Missense_Mutation	SNP	ENST00000282308.4	exon3	c.T208C	p.S70P	exonic	ENSG00000152454.4	.	nonsynonymous SNV	ENSG00000152454.4:ENST00000282308.4:exon3:c.T208C:p.S70P	19q13.43	C3N-03430	.	.	.	.	.	.	.	.	.	5.19	D	D	B	B	.	N	M	T	D	0.147	T	T	T	0.005	0.335	0.124	0.403	T	T	T	T	D	T	1.288	14.300	0.978	N	N	-1.034	0.369	-1.108	0.367	0.002	0.719	0.725	0.723	0.636	.	2.830	0.728	0.159	1.093	0.567	0.000	0.041	0.134	982	Krueppel-associated_box	.	.	.	ZNF256	184	0	311	29	0.0852941176470588	TRUE	TRUE
ENSG00000185052.12	.	BCM	GRCh38.p13	chr20	19585522	19585522	+	T	T	C	Missense_Mutation	SNP	ENST00000328041.11	exon6	c.T590C	p.V197A	exonic	ENSG00000185052.12	.	nonsynonymous SNV	ENSG00000185052.12:ENST00000328041.11:exon6:c.T590C:p.V197A	20p11.23	C3N-03430	.	.	.	.	.	.	.	.	.	11.20	D	T	B	B	D	D	L	T	D	0.754	T	T	D	0.410	0.614	0.613	1.512	T	T	D	D	D	D	3.397	24.400	0.999	D	D	0.189	3.255	0.337	3.941	0.999	0.615	0.563	0.659	0.564	.	5.630	5.630	8.017	1.138	0.609	1.000	0.941	0.998	953	Sodium/calcium_exchanger_membrane_region	.	.	.	SLC24A3	170	2	337	53	0.135897435897436	TRUE	TRUE
ENSG00000198646.14	.	BCM	GRCh38.p13	chr20	34741314	34741314	+	G	G	A	Nonsense_Mutation	SNP	ENST00000359003.7	exon11	c.C4942T	p.Q1648X	exonic	ENSG00000198646.14	.	stopgain	ENSG00000198646.14:ENST00000359003.7:exon11:c.C4942T:p.Q1648X	20q11.22	C3N-03430	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.899	.	.	.	.	.	.	.	.	.	D	D	.	.	7.635	38	0.995	D	N	1.080	16.682	0.932	15.183	0.934	0.707	0.702	0.644	0.714	.	5.460	4.490	4.985	1.176	0.618	1.000	1.000	0.997	335	.	.	.	.	NCOA6	229	1	344	61	0.150617283950617	TRUE	TRUE
ENSG00000214107.8	.	BCM	GRCh38.p13	chrX	30250540	30250540	+	G	G	A	Missense_Mutation	SNP	ENST00000378981.7	exon4	c.G47A	p.R16H	exonic	ENSG00000214107.8	.	nonsynonymous SNV	ENSG00000214107.8:ENST00000378981.7:exon4:c.G47A:p.R16H	Xp21.2	C3N-03430	3.132e-05	0.0001	0.0001	0	0	0	0	0	rs200931248	2.19	T	T	P	B	N	N	L	T	D	0.112	T	T	D	0.022	0.288	0.506	0.109	T	T	T	T	T	T	1.104	12.810	0.988	N	.	.	.	.	.	0.798	.	.	.	.	.	3.990	0.217	0.008	0.230	-0.106	0.008	0.760	0.922	748	Melanoma_associated_antigen,_N-terminal	.	.	ID=COSV66775637;OCCURENCE=1(pancreas)	MAGEB1	93	0	145	36	0.198895027624309	TRUE	TRUE
ENSG00000196440.11	.	BCM	GRCh38.p13	chrX	101489488	101489488	+	A	A	T	Missense_Mutation	SNP	ENST00000423738.4	exon2	c.A899T	p.D300V	exonic	ENSG00000196440.11	.	nonsynonymous SNV	ENSG00000196440.11:ENST00000423738.4:exon2:c.A899T:p.D300V	Xq22.1	C3N-03430	.	.	.	.	.	.	.	.	.	1.12	.	D	.	.	.	N	.	T	.	0.140	T	T	T	0.050	.	0.323	.	T	.	T	T	T	T	1.228	13.850	0.874	N	.	.	.	.	.	0.764	.	.	.	.	.	4.990	-1.120	-0.271	-0.116	0.756	0.000	0.877	0.831	124	.	.	.	.	ARMCX4	280	2	486	42	0.0795454545454545	TRUE	TRUE
ENSG00000133124.11	.	BCM	GRCh38.p13	chrX	108733727	108733727	+	G	G	A	Missense_Mutation	SNP	ENST00000372129.3	exon1	c.C2618T	p.P873L	exonic	ENSG00000133124.11	.	nonsynonymous SNV	ENSG00000133124.11:ENST00000372129.3:exon1:c.C2618T:p.P873L	Xq22.3	C3N-03430	.	.	.	.	.	.	.	.	.	4.19	D	D	B	B	N	N	L	T	D	0.035	T	T	T	0.019	0.250	0.043	0.504	T	D	T	T	T	T	0.223	3.392	0.939	N	.	.	.	.	.	1.000	.	.	.	.	.	5.080	1.270	-0.144	-0.168	-0.133	0.000	0.004	0.430	256	.	.	.	.	IRS4	507	0	751	89	0.105952380952381	TRUE	TRUE
ENSG00000198354.7	.	BCM	GRCh38.p13	chrX	126165773	126165773	+	A	A	T	Missense_Mutation	SNP	ENST00000360028.4	exon1	c.T152A	p.L51Q	exonic	ENSG00000198354.7	.	nonsynonymous SNV	ENSG00000198354.7:ENST00000360028.4:exon1:c.T152A:p.L51Q	Xq25	C3N-03430	.	.	.	.	.	.	.	.	.	8.18	D	D	P	B	.	D	M	T	D	0.559	T	T	D	0.060	0.276	0.339	.	T	T	T	T	D	T	2.077	19.840	0.984	D	.	.	.	.	.	0.793	.	.	.	.	.	3.110	1.960	2.559	1.214	0.572	1.000	0.303	0.486	937	.	.	.	.	DCAF12L2	418	0	610	62	0.0922619047619048	TRUE	TRUE
ENSG00000008128.23	.	BCM	GRCh38.p13	chr1	1708793	1708793	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000008128.23	ENST00000378633.5:exon9:c.1012+1G>A	.	.	1p36.33	C3N-03430	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	4.956	33	0.905	D	.	0.536	5.327	0.203	3.198	0.019	0.263	0.305	0.084	0.093	0.669	2.670	2.670	2.992	0.799	0.265	1.000	0.068	0.290	649	.	.	.	.	CDK11A	463	0	957	57	0.0562130177514793	NA	TRUE
ENSG00000164270.18	.	BCM	GRCh38.p13	chr5	148548870	148548870	+	T	T	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000164270.18	ENST00000377888.8:exon4:c.153-2A>T	.	.	5q32	C3N-03430	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.224	33	0.995	D	.	1.174	21.606	1.040	21.559	0.999	0.061	0.063	0.063	0.059	0.981	5.900	5.900	8.017	1.138	0.665	1.000	1.000	0.991	778	.	.	.	.	HTR4	175	0	298	39	0.115727002967359	TRUE	TRUE
ENSG00000144057.15	.	BCM	GRCh38.p13	chr2	106806720	106806720	+	C	C	T	Silent	SNP	ENST00000409382.7	exon6	c.G1548A	p.A516A	exonic	ENSG00000144057.15	.	synonymous SNV	ENSG00000144057.15:ENST00000409382.7:exon6:c.G1548A:p.A516A	2q12.3	C3N-03430	1.65e-05	0	0	0	0	3.004e-05	0	0	rs764850258	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ST6GAL2	224	1	314	52	0.14207650273224	TRUE	NA
ENSG00000183091.19	.	BCM	GRCh38.p13	chr2	151696685	151696685	+	G	G	A	Silent	SNP	ENST00000172853.14	exon17	c.C1521T	p.D507D	exonic	ENSG00000183091.19	.	synonymous SNV	ENSG00000183091.19:ENST00000172853.14:exon17:c.C1521T:p.D507D	2q23.3	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEB	186	0	339	20	0.0557103064066852	TRUE	TRUE
ENSG00000185774.16	.	BCM	GRCh38.p13	chr4	20882627	20882627	+	C	C	T	Silent	SNP	ENST00000382152.7	exon2	c.G144A	p.T48T	exonic	ENSG00000185774.16	.	synonymous SNV	ENSG00000185774.16:ENST00000382152.7:exon2:c.G144A:p.T48T	4p15.31	C3N-03430	.	.	.	.	.	.	.	.	rs368526954	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62854605;OCCURENCE=1(ovary)	KCNIP4	322	0	617	57	0.0845697329376855	TRUE	TRUE
ENSG00000112902.12	.	BCM	GRCh38.p13	chr5	9054175	9054175	+	A	A	G	Silent	SNP	ENST00000382496.10	exon19	c.T2601C	p.S867S	exonic	ENSG00000112902.12	.	synonymous SNV	ENSG00000112902.12:ENST00000382496.10:exon19:c.T2601C:p.S867S	5p15.31	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEMA5A	246	0	461	34	0.0686868686868687	TRUE	TRUE
ENSG00000204371.11	.	BCM	GRCh38.p13	chr6	31887031	31887031	+	C	C	T	Silent	SNP	ENST00000375537.8	exon16	c.G2082A	p.Q694Q	exonic	ENSG00000204371.11	.	synonymous SNV	ENSG00000204371.11:ENST00000375537.8:exon16:c.G2082A:p.Q694Q	6p21.33	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64997676;OCCURENCE=1(oesophagus)	EHMT2	370	0	601	60	0.0907715582450832	TRUE	TRUE
ENSG00000257923.11	.	BCM	GRCh38.p13	chr7	102248514	102248514	+	G	G	A	Silent	SNP	ENST00000292535.12	exon24	c.G3990A	p.A1330A	exonic	ENSG00000257923.11	.	synonymous SNV	ENSG00000257923.11:ENST00000292535.12:exon24:c.G3990A:p.A1330A	7q22.1	C3N-03430	7.981e-05	0	0	0	0	8.873e-05	0	0.0001	rs782420178	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CUX1	325	1	574	56	0.0888888888888889	TRUE	NA
ENSG00000165156.15	.	BCM	GRCh38.p13	chr8	123254921	123254921	+	A	A	G	Silent	SNP	ENST00000395571.8	exon3	c.T1026C	p.S342S	exonic	ENSG00000165156.15	.	synonymous SNV	ENSG00000165156.15:ENST00000395571.8:exon3:c.T1026C:p.S342S	8q24.13	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZHX1	199	0	383	86	0.183368869936034	TRUE	TRUE
ENSG00000197651.4	.	BCM	GRCh38.p13	chr12	90954185	90954185	+	C	C	T	Silent	SNP	ENST00000358859.3	exon1	c.G558A	p.P186P	exonic	ENSG00000197651.4	.	synonymous SNV	ENSG00000197651.4:ENST00000358859.3:exon1:c.G558A:p.P186P	12q21.33	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCER1	239	0	398	45	0.101580135440181	TRUE	NA
ENSG00000166091.21	.	BCM	GRCh38.p13	chr14	23379301	23379301	+	T	T	G	Silent	SNP	ENST00000339180.9	exon5	c.T576G	p.V192V	exonic	ENSG00000166091.21	.	synonymous SNV	ENSG00000166091.21:ENST00000339180.9:exon5:c.T576G:p.V192V	14q11.2	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CMTM5	143	0	255	22	0.0794223826714801	TRUE	TRUE
ENSG00000119596.18	.	BCM	GRCh38.p13	chr14	74799509	74799509	+	A	A	G	Silent	SNP	ENST00000325680.12	exon5	c.A4212G	p.R1404R	exonic	ENSG00000119596.18	.	synonymous SNV	ENSG00000119596.18:ENST00000325680.12:exon5:c.A4212G:p.R1404R	14q24.3	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	YLPM1	178	0	284	68	0.193181818181818	TRUE	TRUE
ENSG00000165953.9	.	BCM	GRCh38.p13	chr14	94496522	94496522	+	G	G	A	Silent	SNP	ENST00000341228.2	exon4	c.C756T	p.D252D	exonic	ENSG00000165953.9	.	synonymous SNV	ENSG00000165953.9:ENST00000341228.2:exon4:c.C756T:p.D252D	14q32.13	C3N-03430	4.946e-05	9.61e-05	8.637e-05	0	0	2.999e-05	0	0.0001	rs761146045	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SERPINA12	187	0	327	61	0.157216494845361	TRUE	NA
ENSG00000185634.12	.	BCM	GRCh38.p13	chr15	48834937	48834937	+	G	G	A	Silent	SNP	ENST00000332408.9	exon11	c.C1569T	p.S523S	exonic	ENSG00000185634.12	.	synonymous SNV	ENSG00000185634.12:ENST00000332408.9:exon11:c.C1569T:p.S523S	15q21.1	C3N-03430	0.1045	0.0389	0.0788	0.0684	0.1767	0.1144	0.1083	0.1133	rs1426199	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60112821;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	SHC4	277	0	458	47	0.0930693069306931	TRUE	TRUE
ENSG00000266074.8	.	BCM	GRCh38.p13	chr17	81461788	81461788	+	C	C	T	Silent	SNP	ENST00000584436.7	exon27	c.C7218T	p.A2406A	exonic	ENSG00000266074.8	.	synonymous SNV	ENSG00000266074.8:ENST00000584436.7:exon27:c.C7218T:p.A2406A	17q25.3	C3N-03430	.	.	.	.	.	.	.	.	rs782067875	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BAHCC1	119	0	165	56	0.253393665158371	TRUE	NA
ENSG00000180479.14	.	BCM	GRCh38.p13	chr19	37566065	37566065	+	A	A	G	Silent	SNP	ENST00000451802.7	exon4	c.T363C	p.S121S	exonic	ENSG00000180479.14	.	synonymous SNV	ENSG00000180479.14:ENST00000451802.7:exon4:c.T363C:p.S121S	19q13.12	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF571	180	0	387	23	0.0560975609756098	TRUE	TRUE
ENSG00000142512.15	.	BCM	GRCh38.p13	chr19	51414493	51414493	+	C	C	T	Silent	SNP	ENST00000339313.10	exon9	c.G1638A	p.T546T	exonic	ENSG00000142512.15	.	synonymous SNV	ENSG00000142512.15:ENST00000339313.10:exon9:c.G1638A:p.T546T	19q13.41	C3N-03430	1.716e-05	0	0	0	0	3.096e-05	0	0	rs201661934	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59482899;OCCURENCE=1(endometrium)	SIGLEC10	249	1	482	72	0.129963898916967	TRUE	TRUE
ENSG00000100285.10	.	BCM	GRCh38.p13	chr22	29481060	29481060	+	C	C	T	Silent	SNP	ENST00000310624.7	exon1	c.C798T	p.D266D	exonic	ENSG00000100285.10	.	synonymous SNV	ENSG00000100285.10:ENST00000310624.7:exon1:c.C798T:p.D266D	22q12.2	C3N-03430	9.406e-05	0	0	0	.	0	0	0.0001	rs571252099	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEFH	368	0	534	130	0.19578313253012	TRUE	NA
ENSG00000185985.10	.	BCM	GRCh38.p13	chrX	145824468	145824468	+	C	C	T	Silent	SNP	ENST00000335565.5	exon5	c.C2043T	p.D681D	exonic	ENSG00000185985.10	.	synonymous SNV	ENSG00000185985.10:ENST00000335565.5:exon5:c.C2043T:p.D681D	Xq27.3	C3N-03430	6.851e-05	0.0002	0	0	0	6.265e-05	0	9.898e-05	rs182696674	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLITRK2	325	0	515	37	0.0670289855072464	TRUE	NA
ENSG00000237978.6	.	BCM	GRCh38.p13	chr3	178843218	178843218	+	T	T	G	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000237978.6	.	.	.	3q26.32	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCNMB2-AS1	105	0	216	15	0.0649350649350649	TRUE	NA
ENSG00000155011.9	.	BCM	GRCh38.p13	chr4	107188431	107188431	+	C	C	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000155011.9;ENSG00000213522.4	dist=152118;dist=14918	.	.	4q25	C3N-03430	.	.	.	.	.	.	.	.	rs558251635	1.13	D	.	.	.	.	N	.	T	N	0.307	T	T	T	0.044	0.363	0.093	.	.	.	T	T	T	T	0.708	8.526	0.600	N	N	-0.477	1.223	-0.612	1.028	0.000	0.487	0.574	0.574	0.613	.	4.640	2.480	0.905	0.126	0.599	0.001	0.039	0.011	557	.	.	.	.	DKK2	101	0	158	10	0.0595238095238095	TRUE	NA
ENSG00000138650.9	.	BCM	GRCh38.p13	chr4	133163886	133163886	+	-	NA	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000138650.9	.	.	.	4q28.3	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDH10	NA	NA	NA	NA	NA	NA	NA
ENSG00000016402.13	.	BCM	GRCh38.p13	chr6	137009286	137009286	+	G	G	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000016402.13	.	.	.	6q23.3	C3N-03430	.	.	.	.	.	.	.	.	.	1.14	T	D	.	.	.	N	.	T	N	0.181	T	T	T	0.060	0.444	0.371	.	.	.	T	T	T	T	-0.464	0.142	0.728	N	N	-1.003	0.401	-1.202	0.281	0.001	0.497	0.590	0.547	0.542	.	4.300	-4.350	-0.257	0.145	-0.250	0.000	0.001	0.000	811	.	.	.	.	IL20RA	79	0	124	35	0.220125786163522	TRUE	TRUE
ENSG00000136267.13	.	BCM	GRCh38.p13	chr7	14209543	14209543	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000136267.13	.	.	.	7p21.2	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DGKB	200	1	415	43	0.0938864628820961	TRUE	NA
ENSG00000276759.2	.	BCM	GRCh38.p13	chr9	26110093	26110093	+	T	T	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000276759.2	.	.	.	9p21.2	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL353753.1	104	0	180	26	0.12621359223301	TRUE	NA
ENSG00000160584.16	.	BCM	GRCh38.p13	chr11	116950182	116950182	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000160584.16	.	.	.	11q23.3	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SIK3	123	0	205	15	0.0681818181818182	TRUE	NA
ENSG00000258723.1	.	BCM	GRCh38.p13	chr14	78297859	78297859	+	A	A	C	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000258723.1;ENSG00000258719.1	dist=14483;dist=397462	.	.	14q24.3	C3N-03430	.	.	.	.	.	.	.	.	.	3.7	.	D	.	.	.	.	.	.	.	0.630	T	T	.	0.111	.	.	.	.	T	.	.	.	D	3.348	24.300	0.993	D	N	0.994	13.745	0.841	11.464	0.997	0.487	0.574	0.492	0.564	.	6.020	4.870	5.512	1.298	0.740	1.000	1.000	0.998	743	.	.	.	.	AF099810.1	187	1	350	34	0.0885416666666667	TRUE	TRUE
ENSG00000140807.7	.	BCM	GRCh38.p13	chr16	50616090	50616090	+	A	A	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000140807.7	.	.	.	16q12.1	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NKD1	71	0	151	15	0.0903614457831325	TRUE	NA
ENSG00000167046.4	.	BCM	GRCh38.p13	chr20	62642120	62642120	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000167046.4	.	.	.	20q13.33	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL357033.1	139	0	261	53	0.168789808917197	TRUE	NA
ENSG00000204118.2	.	BCM	GRCh38.p13	chrX	73127562	73127562	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000204118.2	.	.	.	Xq13.2	C3N-03430	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NAP1L6P	100	0	127	40	0.239520958083832	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178604043	178604043	+	C	C	T	Missense_Mutation	SNP	ENST00000591111.5	exon232	c.G49721A	p.R16574H	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon232:c.G49721A:p.R16574H	2q31.2	C3L-02809	8.285e-06	0	0	0	0	1.499e-05	0	0	rs183010574	9.17	D	.	D	D	.	D	M	T	D	0.432	T	T	T	0.306	0.501	0.343	0.504	T	.	T	T	T	D	3.353	24.300	0.936	D	D	0.745	7.799	0.766	9.183	1.000	0.554	0.546	0.602	0.621	.	6.160	6.160	3.914	1.026	0.599	1.000	1.000	0.999	416	Fibronectin_type_III	.	.	.	TTN	123	0	178	23	0.114427860696517	TRUE	NA
ENSG00000115556.14	.	BCM	GRCh38.p13	chr2	218618606	218618606	+	G	G	A	Missense_Mutation	SNP	ENST00000450993.7	exon4	c.G209A	p.R70H	exonic	ENSG00000115556.14	.	nonsynonymous SNV	ENSG00000115556.14:ENST00000450993.7:exon4:c.G209A:p.R70H	2q35	C3L-02809	2.495e-05	0	0	0	0	1.504e-05	0	0.0001	rs547899357	17.20	D	D	D	D	D	D	M	T	D	0.748	D	D	D	0.506	0.635	0.871	0.928	T	D	T	D	D	D	3.844	26.000	0.964	D	D	0.829	9.379	0.717	8.080	1.000	0.659	0.611	0.725	0.568	.	5.040	5.040	7.604	1.176	0.676	1.000	0.955	0.976	925	Pleckstrin_homology_domain	.	.	.	PLCD4	326	0	319	93	0.225728155339806	TRUE	NA
ENSG00000144589.22	.	BCM	GRCh38.p13	chr2	219614171	219614183	+	GTCTCTGCCCCCT	GTCTCTGCCCCCT	-	Frame_Shift_Del	DEL	ENST00000456909.6	exon22	c.2727_2739del	p.S910Pfs*54	exonic	ENSG00000144589.22	.	frameshift deletion	ENSG00000144589.22:ENST00000456909.6:exon22:c.2727_2739del:p.S910Pfs*54	2q35	C3L-02809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STK11IP	402	0	431	91	0.174329501915709	TRUE	TRUE
ENSG00000144619.15	.	BCM	GRCh38.p13	chr3	3037296	3037296	+	G	G	A	Missense_Mutation	SNP	ENST00000418658.6	exon18	c.G2060A	p.R687H	exonic	ENSG00000144619.15	.	nonsynonymous SNV	ENSG00000144619.15:ENST00000418658.6:exon18:c.G2060A:p.R687H	3p26.2	C3L-02809	2.472e-05	0	0	0	0	4.497e-05	0	0	rs760085098	4.20	T	T	P	B	D	N	L	T	N	0.361	T	T	T	0.052	0.388	0.701	0.327	T	T	T	T	D	D	2.485	22.400	0.998	D	N	-0.101	2.173	-0.103	2.039	0.000	0.554	0.588	0.608	0.564	.	5.480	0.315	1.805	1.176	0.676	0.961	0.983	0.688	953	Fibronectin_type_III	.	.	ID=COSV61868851;OCCURENCE=2(large_intestine),1(stomach),1(upper_aerodigestive_tract)	CNTN4	604	0	477	78	0.140540540540541	TRUE	TRUE
ENSG00000144712.12	.	BCM	GRCh38.p13	chr3	12817166	12817166	+	G	G	A	Missense_Mutation	SNP	ENST00000456430.6	exon10	c.G2234A	p.R745H	exonic	ENSG00000144712.12	.	nonsynonymous SNV	ENSG00000144712.12:ENST00000456430.6:exon10:c.G2234A:p.R745H	3p25.2	C3L-02809	8.468e-06	0	0	0.0001	0	0	0	0	rs755177838	2.20	T	T	B	B	N	N	N	T	N	0.083	T	T	D	0.018	0.389	0.375	0.219	T	T	T	T	T	D	0.298	4.265	0.963	N	N	-0.953	0.456	-0.953	0.550	0.998	0.566	0.610	0.679	0.492	.	4.730	0.145	0.428	-0.516	-0.124	0.000	0.283	0.556	840	.	.	.	ID=COSV99929621;OCCURENCE=1(stomach)	CAND2	263	0	221	55	0.199275362318841	TRUE	NA
ENSG00000169855.20	.	BCM	GRCh38.p13	chr3	78633955	78633955	+	T	T	A	Missense_Mutation	SNP	ENST00000464233.6	exon24	c.A3461T	p.D1154V	exonic	ENSG00000169855.20	.	nonsynonymous SNV	ENSG00000169855.20:ENST00000464233.6:exon24:c.A3461T:p.D1154V	3p12.3	C3L-02809	.	.	.	.	.	.	.	.	.	14.20	D	D	P	B	D	D	M	D	D	0.929	T	T	D	0.674	0.260	0.891	0.759	T	T	D	D	D	D	3.622	25.100	0.995	D	D	0.435	4.570	0.495	5.110	1.000	0.661	0.623	0.644	0.668	.	5.820	5.820	7.652	1.138	0.665	1.000	1.000	0.921	732	.	.	.	.	ROBO1	217	0	213	25	0.105042016806723	TRUE	TRUE
ENSG00000174948.6	.	BCM	GRCh38.p13	chr3	154338150	154338150	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000389740.3	exon4	c.1744dupA	p.I582Nfs*6	exonic	ENSG00000174948.6	.	frameshift insertion	ENSG00000174948.6:ENST00000389740.3:exon4:c.1744dupA:p.I582Nfs*6	3q25.2	C3L-02809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPR149	NA	NA	NA	NA	NA	NA	NA
ENSG00000170561.13	.	BCM	GRCh38.p13	chr5	2748564	2748564	+	G	G	T	Missense_Mutation	SNP	ENST00000302057.6	exon3	c.C1144A	p.L382I	exonic	ENSG00000170561.13	.	nonsynonymous SNV	ENSG00000170561.13:ENST00000302057.6:exon3:c.C1144A:p.L382I	5p15.33	C3L-02809	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	N	T	N	0.134	T	T	D	0.052	0.352	0.345	0.466	D	T	T	T	T	D	1.861	18.190	0.823	N	N	-0.670	0.865	-0.534	1.147	1.000	0.722	0.574	0.699	0.639	.	4.670	2.510	2.637	1.064	0.560	1.000	0.998	0.811	933	.	.	.	.	IRX2	492	0	513	48	0.0855614973262032	TRUE	TRUE
ENSG00000164176.13	.	BCM	GRCh38.p13	chr5	84064838	84064838	+	G	G	A	Missense_Mutation	SNP	ENST00000296591.10	exon8	c.C814T	p.R272C	exonic	ENSG00000164176.13	.	nonsynonymous SNV	ENSG00000164176.13:ENST00000296591.10:exon8:c.C814T:p.R272C	5q14.3	C3L-02809	8.323e-06	0	0	0	0	1.507e-05	0	0	rs752603385	14.20	T	T	P	P	D	D	M	D	N	0.718	D	D	D	0.671	0.490	0.977	0.894	T	D	D	D	D	D	3.554	24.900	0.998	D	D	0.415	4.439	0.428	4.564	0.309	0.693	0.588	0.659	0.564	.	5.510	5.510	5.949	1.176	0.618	1.000	0.961	0.483	967	Coagulation_factor_5/8_C-terminal_domain	.	.	ID=COSV56901771;OCCURENCE=7(skin)	EDIL3	55	0	90	12	0.117647058823529	TRUE	TRUE
ENSG00000131437.15	.	BCM	GRCh38.p13	chr5	132726166	132726166	+	G	G	A	Missense_Mutation	SNP	ENST00000378746.8	exon4	c.C472T	p.R158C	exonic	ENSG00000131437.15	.	nonsynonymous SNV	ENSG00000131437.15:ENST00000378746.8:exon4:c.C472T:p.R158C	5q31.1	C3L-02809	0.0008	0	0.0080	0	0	0	0	0.0001	rs532600022	17.20	D	D	D	D	D	D	M	T	D	0.702	D	D	D	0.692	.	0.802	2.020	D	D	T	D	T	D	4.569	32	0.999	D	D	0.910	11.300	0.848	11.701	1.000	0.732	0.634	0.653	0.728	.	5.690	5.690	5.027	1.176	0.618	1.000	1.000	0.999	891	Kinesin_motor_domain	.	.	ID=COSV66415369;OCCURENCE=1(NS),1(stomach)	KIF3A	113	0	159	49	0.235576923076923	TRUE	TRUE
ENSG00000186472.20	.	BCM	GRCh38.p13	chr7	83156212	83156212	+	A	A	T	Missense_Mutation	SNP	ENST00000333891.14	exon2	c.T429A	p.D143E	exonic	ENSG00000186472.20	.	nonsynonymous SNV	ENSG00000186472.20:ENST00000333891.14:exon2:c.T429A:p.D143E	7q21.11	C3L-02809	.	.	.	.	.	.	.	.	.	1.19	T	T	P	B	.	N	L	T	N	0.366	T	T	T	0.063	0.112	0.363	0.035	T	T	T	T	T	T	1.327	14.580	0.990	D	N	0.067	2.757	0.118	2.809	0.000	0.615	0.574	0.659	0.613	.	5.630	3.280	1.403	1.312	0.756	1.000	1.000	0.997	845	.	.	.	.	PCLO	225	0	219	12	0.051948051948052	TRUE	TRUE
ENSG00000146909.8	.	BCM	GRCh38.p13	chr7	156950237	156950237	+	C	C	T	Missense_Mutation	SNP	ENST00000275820.4	exon1	c.C500T	p.T167I	exonic	ENSG00000146909.8	.	nonsynonymous SNV	ENSG00000146909.8:ENST00000275820.4:exon1:c.C500T:p.T167I	7q36.3	C3L-02809	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.124	T	T	T	0.019	0.261	0.294	0.983	T	T	T	T	T	T	1.394	15.040	0.964	N	N	-0.664	0.874	-0.640	0.987	1.000	0.243	0.484	0.391	0.373	.	4.080	3.160	0.241	0.997	0.599	0.000	0.744	0.216	810	.	.	.	.	NOM1	225	0	243	41	0.144366197183099	TRUE	TRUE
ENSG00000147485.13	.	BCM	GRCh38.p13	chr8	51409054	51409054	+	G	G	A	Missense_Mutation	SNP	ENST00000356297.5	exon17	c.C2570T	p.A857V	exonic	ENSG00000147485.13	.	nonsynonymous SNV	ENSG00000147485.13:ENST00000356297.5:exon17:c.C2570T:p.A857V	8q11.22	C3L-02809	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	N	N	N	T	D	0.272	T	T	D	0.238	0.554	0.177	0.195	T	T	T	T	T	T	1.274	14.200	0.564	N	N	-0.995	0.409	-1.026	0.457	0.002	0.554	0.588	0.576	0.564	.	3.490	0.493	6.243	-0.892	-0.987	0.985	0.000	0.000	895	Peroxidasin,_peroxidase_domain	.	.	ID=COSV62478535;OCCURENCE=1(oesophagus),1(central_nervous_system),1(ovary),1(stomach),1(pancreas)	PXDNL	318	0	231	35	0.131578947368421	TRUE	TRUE
ENSG00000176566.5	.	BCM	GRCh38.p13	chr8	87873436	87873436	+	C	C	T	Missense_Mutation	SNP	ENST00000319675.5	exon1	c.G536A	p.S179N	exonic	ENSG00000176566.5	.	nonsynonymous SNV	ENSG00000176566.5:ENST00000319675.5:exon1:c.G536A:p.S179N	8q21.3	C3L-02809	.	.	.	.	.	.	.	.	.	5.20	D	D	P	B	D	N	L	T	N	0.171	T	T	T	0.205	0.709	0.700	0.248	T	T	T	T	D	D	1.292	14.330	0.668	N	N	-0.966	0.441	-1.147	0.330	0.539	0.487	0.574	0.547	0.564	.	1.220	-2.440	0.724	-0.980	-1.184	1.000	0.088	0.095	856	.	.	.	ID=COSV60476327;OCCURENCE=1(skin)	DCAF4L2	668	0	679	67	0.0898123324396783	TRUE	TRUE
ENSG00000197919.6	.	BCM	GRCh38.p13	chr9	21440842	21440842	+	T	T	G	Missense_Mutation	SNP	ENST00000276927.3	exon1	c.T335G	p.L112R	exonic	ENSG00000197919.6	.	nonsynonymous SNV	ENSG00000197919.6:ENST00000276927.3:exon1:c.T335G:p.L112R	9p21.3	C3L-02809	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	N	H	T	D	0.836	T	T	T	0.303	0.790	0.778	3.211	T	T	D	D	D	D	3.064	23.500	0.995	D	N	0.318	3.871	0.041	2.506	0.315	0.516	0.610	0.574	0.542	.	3.120	3.120	4.620	1.100	0.588	0.662	0.005	0.011	883	.	.	.	.	IFNA1	67	0	46	16	0.258064516129032	NA	TRUE
ENSG00000148120.16	.	BCM	GRCh38.p13	chr9	94955245	94955245	+	C	C	T	Missense_Mutation	SNP	ENST00000375315.6	exon7	c.C1730T	p.P577L	exonic	ENSG00000148120.16	.	nonsynonymous SNV	ENSG00000148120.16:ENST00000375315.6:exon7:c.C1730T:p.P577L	9q22.32	C3L-02809	1.653e-05	0.0002	0	0	0	0	0	0	rs143555020	7.15	D	D	.	.	N	D	.	T	D	0.407	T	T	D	0.151	.	0.414	0.694	.	.	T	T	D	T	2.327	21.700	0.985	D	N	0.153	3.103	0.048	2.530	1.000	0.615	0.546	0.659	0.568	.	5.000	4.110	2.015	0.129	-0.171	0.761	0.768	0.235	584	Peptidase_M1,_membrane_alanine_aminopeptidase,_N-terminal	.	.	.	AOPEP	164	0	118	38	0.243589743589744	TRUE	NA
ENSG00000165695.10	.	BCM	GRCh38.p13	chr9	132854918	132854918	+	G	G	A	Missense_Mutation	SNP	ENST00000298545.4	exon5	c.C341T	p.P114L	exonic	ENSG00000165695.10	.	nonsynonymous SNV	ENSG00000165695.10:ENST00000298545.4:exon5:c.C341T:p.P114L	9q34.13	C3L-02809	.	.	.	.	.	.	.	.	.	10.20	D	D	P	P	D	N	H	T	D	0.593	T	D	D	0.354	0.427	0.668	0.488	T	D	T	T	D	T	3.088	23.600	0.995	D	N	0.257	3.564	0.053	2.551	1.000	0.516	0.610	0.547	0.564	.	3.490	3.490	3.924	1.176	0.618	1.000	0.075	0.103	792	.	.	.	.	AK8	202	0	180	27	0.130434782608696	TRUE	TRUE
ENSG00000048740.18	.	BCM	GRCh38.p13	chr10	11217487	11217487	+	A	A	G	Missense_Mutation	SNP	ENST00000416382.6	exon3	c.A313G	p.N105D	exonic	ENSG00000048740.18	.	nonsynonymous SNV	ENSG00000048740.18:ENST00000416382.6:exon3:c.A313G:p.N105D	10p14	C3L-02809	.	.	.	.	.	.	.	.	.	11.20	T	D	D	D	D	D	N	T	N	0.740	T	T	D	0.322	0.612	0.599	.	D	T	T	T	D	D	3.353	24.300	0.996	D	D	0.627	6.215	0.683	7.441	1.000	0.706	0.725	0.710	0.613	.	5.540	5.540	8.947	1.312	0.756	1.000	1.000	1.000	909	RNA_recognition_motif_domain;CELF1/2,_RNA_recognition_motif_1	.	.	.	CELF2	168	0	188	57	0.23265306122449	TRUE	TRUE
ENSG00000069431.11	.	BCM	GRCh38.p13	chr12	21910225	21910225	+	C	C	T	Missense_Mutation	SNP	ENST00000261201.8	exon8	c.G1252A	p.A418T	exonic	ENSG00000069431.11	.	nonsynonymous SNV	ENSG00000069431.11:ENST00000261201.8:exon8:c.G1252A:p.A418T	12p12.1	C3L-02809	1.651e-05	0	0	0.0001	0	1.501e-05	0	0	rs781206225	15.20	D	D	P	P	D	D	L	D	N	0.503	D	D	D	0.555	0.641	0.924	0.807	D	D	D	T	D	D	3.066	23.600	0.999	D	D	0.503	5.057	0.594	6.155	1.000	0.487	0.574	0.547	0.564	.	5.800	5.800	6.158	0.992	0.580	1.000	0.991	0.990	622	ABC_transporter_type_1,_transmembrane_domain	.	.	ID=COSV53987558;OCCURENCE=1(large_intestine)	ABCC9	260	0	315	73	0.188144329896907	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02809	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	326	0	362	158	0.303846153846154	TRUE	TRUE
ENSG00000167548.15	.	BCM	GRCh38.p13	chr12	49053566	49053566	+	T	T	C	Missense_Mutation	SNP	ENST00000301067.11	exon6	c.A749G	p.H250R	exonic	ENSG00000167548.15	.	nonsynonymous SNV	ENSG00000167548.15:ENST00000301067.11:exon6:c.A749G:p.H250R	12q13.12	C3L-02809	.	.	.	.	.	.	.	.	.	17.19	D	.	D	D	N	D	M	D	D	0.865	D	D	D	0.684	0.763	0.822	0.227	D	T	D	D	D	D	3.821	25.900	0.932	D	D	0.814	9.051	0.753	8.862	1.000	0.672	0.702	0.702	0.711	.	5.050	5.050	7.969	1.138	0.665	1.000	1.000	0.997	357	Zinc_finger,_PHD-type;Zinc_finger,_RING-type;Zinc_finger,_PHD-finger	.	.	.	KMT2D	274	0	310	130	0.295454545454545	TRUE	TRUE
ENSG00000133641.18	.	BCM	GRCh38.p13	chr12	88048270	88048270	+	C	C	G	Missense_Mutation	SNP	ENST00000356891.4	exon7	c.C826G	p.P276A	exonic	ENSG00000133641.18	.	nonsynonymous SNV	ENSG00000133641.18:ENST00000356891.4:exon7:c.C826G:p.P276A	12q21.32	C3L-02809	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	N	T	N	0.152	T	T	T	0.050	0.461	0.107	0.196	.	T	T	T	T	T	1.193	13.580	0.785	D	N	-0.494	1.189	-0.323	1.517	0.003	0.706	0.725	0.710	0.714	.	5.730	1.810	1.336	0.126	0.599	1.000	1.000	1.000	876	.	.	.	.	C12orf29	45	1	69	35	0.336538461538462	TRUE	NA
ENSG00000158023.10	.	BCM	GRCh38.p13	chr12	121960672	121960672	+	C	C	T	Missense_Mutation	SNP	ENST00000288912.9	exon14	c.C2221T	p.R741C	exonic	ENSG00000158023.10	.	nonsynonymous SNV	ENSG00000158023.10:ENST00000288912.9:exon14:c.C2221T:p.R741C	12q24.31	C3L-02809	.	.	.	.	.	.	.	.	.	6.19	T	D	D	P	N	N	.	T	N	0.334	T	T	D	0.191	0.500	0.775	0.432	T	T	T	T	D	D	3.519	24.800	0.999	D	N	0.398	4.330	0.424	4.533	0.964	0.615	0.627	0.659	0.568	.	4.820	3.870	3.717	1.002	0.599	1.000	0.953	0.982	783	.	.	.	.	WDR66	334	0	383	87	0.185106382978723	TRUE	NA
ENSG00000158113.13	.	BCM	GRCh38.p13	chr12	122203320	122203320	+	C	C	T	Missense_Mutation	SNP	ENST00000339777.5	exon12	c.C1849T	p.P617S	exonic	ENSG00000158113.13	.	nonsynonymous SNV	ENSG00000158113.13:ENST00000339777.5:exon12:c.C1849T:p.P617S	12q24.31	C3L-02809	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.080	T	T	T	0.035	0.235	0.014	0.245	T	T	T	T	T	T	-0.517	0.109	0.849	N	N	-1.890	0.015	-1.975	0.015	1.000	0.455	0.609	0.607	0.604	.	4.590	-9.190	-1.446	-1.179	-0.978	0.000	0.002	0.000	759	.	.	.	ID=COSV99928274;OCCURENCE=1(pancreas)	LRRC43	98	0	208	25	0.107296137339056	TRUE	TRUE
ENSG00000198542.14	.	BCM	GRCh38.p13	chr13	101583239	101583239	+	A	A	G	Missense_Mutation	SNP	ENST00000376180.8	exon6	c.A751G	p.T251A	exonic	ENSG00000198542.14	.	nonsynonymous SNV	ENSG00000198542.14:ENST00000376180.8:exon6:c.A751G:p.T251A	13q33.1	C3L-02809	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	N	D	N	0.360	T	D	D	0.240	0.356	0.488	0.199	T	T	T	T	T	T	1.748	17.360	0.724	D	N	-0.572	1.039	-0.386	1.397	1.000	0.706	0.574	0.547	0.613	.	5.250	2.570	5.142	0.167	-0.350	1.000	0.998	0.913	945	EGF-like_domain	.	.	.	ITGBL1	269	0	365	40	0.0987654320987654	TRUE	TRUE
ENSG00000139915.21	.	BCM	GRCh38.p13	chr14	47144128	47144128	+	G	G	C	Missense_Mutation	SNP	ENST00000399232.8	exon4	c.C742G	p.L248V	exonic	ENSG00000139915.21	.	nonsynonymous SNV	ENSG00000139915.21:ENST00000399232.8:exon4:c.C742G:p.L248V	14q21.3	C3L-02809	.	.	.	.	.	.	.	.	.	4.19	T	.	B	B	U	D	N	T	N	.	T	T	T	0.056	0.437	0.043	.	T	T	T	T	T	D	2.082	19.880	0.992	D	D	-0.155	2.005	0.041	2.506	0.001	0.487	0.574	0.574	0.564	.	5.730	4.840	4.553	1.155	0.618	1.000	0.998	0.986	832	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	MDGA2	124	0	105	39	0.270833333333333	TRUE	TRUE
ENSG00000165617.14	.	BCM	GRCh38.p13	chr14	58638327	58638327	+	A	A	C	Missense_Mutation	SNP	ENST00000335867.4	exon1	c.A125C	p.Q42P	exonic	ENSG00000165617.14	.	nonsynonymous SNV	ENSG00000165617.14:ENST00000335867.4:exon1:c.A125C:p.Q42P	14q23.1	C3L-02809	.	.	.	.	.	.	.	.	.	6.20	T	T	D	D	N	D	L	T	N	0.280	T	T	D	0.224	0.133	0.812	4.141	D	T	T	T	D	T	3.416	24.500	0.975	N	N	0.308	3.822	0.228	3.325	1.000	0.437	0.607	0.504	0.604	.	3.280	3.280	0.678	1.190	0.552	0.981	1.000	0.993	641	.	.	.	.	DACT1	100	0	109	15	0.120967741935484	TRUE	TRUE
ENSG00000137877.10	.	BCM	GRCh38.p13	chr15	41858972	41858972	+	G	G	A	Missense_Mutation	SNP	ENST00000320955.8	exon48	c.C7997T	p.A2666V	exonic	ENSG00000137877.10	.	nonsynonymous SNV	ENSG00000137877.10:ENST00000320955.8:exon48:c.C7997T:p.A2666V	15q15.1	C3L-02809	0.0002	0	0	0	0.0005	0.0003	0	0.0002	rs377208445	1.20	T	T	B	B	N	N	M	T	N	0.203	T	T	T	0.052	.	0.592	.	T	T	T	T	T	T	0.964	11.170	0.933	N	N	-0.708	0.799	-0.785	0.779	1.000	0.563	0.547	0.506	0.636	.	4.620	2.420	0.416	-0.643	-0.822	0.031	0.002	0.001	198	.	.	.	.	SPTBN5	141	0	163	47	0.223809523809524	TRUE	NA
ENSG00000235711.4	.	BCM	GRCh38.p13	chr15	79294167	79294167	+	C	C	A	Missense_Mutation	SNP	ENST00000421388.3	exon1	c.C883A	p.P295T	exonic	ENSG00000235711.4	.	nonsynonymous SNV	ENSG00000235711.4:ENST00000421388.3:exon1:c.C883A:p.P295T	15q25.1	C3L-02809	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	L	T	N	0.031	T	T	T	0.067	0.212	0.048	.	T	T	T	T	T	T	0.927	10.730	0.791	N	N	-0.639	0.918	-0.524	1.163	0.016	0.447	0.563	0.316	0.613	.	4.720	3.800	0.219	1.000	0.599	0.000	0.987	0.530	900	.	.	.	.	ANKRD34C	266	0	277	47	0.145061728395062	TRUE	TRUE
ENSG00000073417.15	.	BCM	GRCh38.p13	chr15	85109058	85109058	+	C	C	T	Nonsense_Mutation	SNP	ENST00000394553.6	exon12	c.C1042T	p.Q348X	exonic	ENSG00000073417.15	.	stopgain	ENSG00000073417.15:ENST00000394553.6:exon12:c.C1042T:p.Q348X	15q25.3	C3L-02809	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.884	.	.	.	.	.	.	.	.	.	D	D	.	.	7.983	40	0.998	D	N	0.889	10.758	0.699	7.738	1.000	0.732	0.744	0.710	0.714	.	4.010	4.010	6.806	1.010	0.580	1.000	0.994	0.982	595	.	.	.	.	PDE8A	121	0	158	35	0.181347150259067	TRUE	TRUE
ENSG00000140548.10	.	BCM	GRCh38.p13	chr15	90073162	90073162	+	G	G	A	Missense_Mutation	SNP	ENST00000268154.9	exon3	c.G1550A	p.R517Q	exonic	ENSG00000140548.10	.	nonsynonymous SNV	ENSG00000140548.10:ENST00000268154.9:exon3:c.G1550A:p.R517Q	15q26.1	C3L-02809	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	N	D	M	T	D	0.796	T	T	D	0.401	0.601	0.848	1.682	D	T	D	D	D	D	4.476	32	1.000	D	D	0.864	10.163	0.837	11.298	1.000	0.707	0.702	0.571	0.714	.	5.020	5.020	10.003	1.176	0.676	1.000	1.000	0.998	774	Zinc_finger_C2H2-type	.	.	.	ZNF710	345	0	389	122	0.238747553816047	TRUE	TRUE
ENSG00000225614.4	.	BCM	GRCh38.p13	chr16	88427796	88427796	+	C	C	T	Missense_Mutation	SNP	ENST00000565624.3	exon3	c.C326T	p.A109V	exonic	ENSG00000225614.4	.	nonsynonymous SNV	ENSG00000225614.4:ENST00000565624.3:exon3:c.C326T:p.A109V	16q24.2	C3L-02809	.	.	.	.	.	.	.	.	.	2.16	D	T	.	.	.	N	.	T	N	0.046	T	T	D	0.064	.	0.421	.	T	T	T	T	T	T	-0.144	0.673	0.651	N	N	-1.255	0.191	-1.241	0.251	0.038	0.554	0.547	0.576	0.568	.	3.760	1.760	1.159	-1.049	-1.423	0.000	0.000	0.001	.	.	.	.	ID=COSV71258289;OCCURENCE=1(oesophagus),2(large_intestine),1(pancreas)	ZNF469	265	0	330	70	0.175	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674230	7674230	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.G733A	p.G245S	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.G733A:p.G245S	17p13.1	C3L-02809	8.239e-06	0	0	0	0	1.498e-05	0	0	rs28934575	19.20	D	D	D	D	D	D	M	D	D	0.921	D	D	D	0.947	.	0.994	0.387	T	D	D	D	D	D	4.069	27.500	0.999	D	D	0.816	9.103	0.750	8.806	1.000	0.722	0.702	0.725	0.735	.	4.620	4.620	7.905	1.021	0.596	1.000	0.893	0.975	433	p53,_DNA-binding_domain	.	.	ID=COSV52661877;OCCURENCE=4(salivary_gland),48(breast),1(penis),4(liver),34(oesophagus),1(adrenal_gland),2(cervix),215(large_intestine),43(central_nervous_system),3(biliary_tract),27(ovary),6(vulva),1(bone),3(NS),55(stomach),33(haematopoietic_and_lymphoid_tissue),2(kidney),4(soft_tissue),14(urinary_tract),18(pancreas),12(skin),16(prostate),17(lung),6(thyroid),29(upper_aerodigestive_tract),7(small_intestine),13(endometrium)	TP53	429	0	307	108	0.260240963855422	TRUE	TRUE
ENSG00000109061.10	.	BCM	GRCh38.p13	chr17	10497287	10497287	+	G	G	A	Nonsense_Mutation	SNP	ENST00000226207.6	exon32	c.C4531T	p.Q1511X	exonic	ENSG00000109061.10	.	stopgain	ENSG00000109061.10:ENST00000226207.6:exon32:c.C4531T:p.Q1511X	17p13.1	C3L-02809	8.332e-06	9.927e-05	0	0	0	0	0	0	rs758051881	5.6	.	.	.	.	U	A	.	.	.	0.777	.	.	.	.	.	.	.	.	.	D	D	.	.	8.810	45	0.996	D	D	1.035	15.068	0.891	13.356	0.026	0.487	0.590	0.574	0.564	.	5.660	5.660	1.240	1.176	0.676	0.996	0.995	0.998	169	Myosin_tail	.	.	.	MYH1	109	0	95	46	0.326241134751773	TRUE	NA
ENSG00000101639.18	.	BCM	GRCh38.p13	chr18	13100492	13100492	+	C	C	T	Missense_Mutation	SNP	ENST00000506447.5	exon38	c.C6851T	p.T2284I	exonic	ENSG00000101639.18	.	nonsynonymous SNV	ENSG00000101639.18:ENST00000506447.5:exon38:c.C6851T:p.T2284I	18p11.21	C3L-02809	.	.	.	.	.	.	.	.	rs374861272	10.17	D	D	.	.	D	D	.	T	D	0.557	T	T	D	0.207	.	0.624	0.489	T	T	T	T	D	D	3.630	25.100	0.999	D	D	0.782	8.439	0.754	8.887	1.000	0.732	0.725	0.725	0.728	.	5.520	5.520	4.290	1.025	0.599	1.000	0.998	0.997	481	.	.	.	.	CEP192	179	0	160	108	0.402985074626866	TRUE	NA
ENSG00000105549.11	.	BCM	GRCh38.p13	chr19	362307	362307	+	G	G	A	Missense_Mutation	SNP	ENST00000342640.9	exon8	c.C1033T	p.R345C	exonic	ENSG00000105549.11	.	nonsynonymous SNV	ENSG00000105549.11:ENST00000342640.9:exon8:c.C1033T:p.R345C	19p13.3	C3L-02809	2.499e-05	0	0	0	0	4.524e-05	0	0	rs371760649	9.20	D	D	D	D	D	N	M	T	D	0.728	T	T	T	0.263	.	0.297	0.370	T	T	T	T	D	D	3.405	24.400	0.999	N	N	0.280	3.675	0.102	2.741	0.029	0.554	0.588	0.479	0.563	.	3.980	3.980	2.325	1.033	0.654	0.436	0.155	0.027	982	.	.	.	ID=COSV61073683;OCCURENCE=1(large_intestine)	THEG	113	0	127	23	0.153333333333333	TRUE	TRUE
ENSG00000105255.11	.	BCM	GRCh38.p13	chr19	4323108	4323108	+	G	G	A	Missense_Mutation	SNP	ENST00000221856.11	exon11	c.G1162A	p.A388T	exonic	ENSG00000105255.11	.	nonsynonymous SNV	ENSG00000105255.11:ENST00000221856.11:exon11:c.G1162A:p.A388T	19p13.3	C3L-02809	8.46e-06	0.0001	0	0	0	0	0	0	rs370463498	1.20	T	T	B	B	N	N	L	T	N	0.374	T	T	D	0.123	.	0.168	0.524	T	T	T	T	T	T	1.885	18.370	0.988	N	N	-0.629	0.936	-0.537	1.142	0.064	0.635	0.634	0.000	0.646	.	4.550	3.470	0.623	1.089	0.511	0.000	0.778	0.956	928	0.000	.	.	ID=COSV55695576;OCCURENCE=1(upper_aerodigestive_tract)	FSD1	501	0	461	84	0.154128440366972	TRUE	TRUE
ENSG00000181143.15	.	BCM	GRCh38.p13	chr19	8952257	8952257	+	C	C	A	Missense_Mutation	SNP	ENST00000397910.8	exon3	c.G24513T	p.Q8171H	exonic	ENSG00000181143.15	.	nonsynonymous SNV	ENSG00000181143.15:ENST00000397910.8:exon3:c.G24513T:p.Q8171H	19p13.2	C3L-02809	.	.	.	.	.	.	.	.	.	1.15	T	D	.	.	.	N	.	T	N	0.116	T	T	T	0.029	0.200	0.014	.	T	.	T	T	T	T	-1.242	0.002	0.328	N	N	-1.237	0.202	-1.378	0.163	0.009	0.554	0.574	0.618	0.564	.	3.310	-4.950	-5.435	-1.060	-0.199	0.000	0.000	0.000	917	.	.	.	.	MUC16	307	0	300	44	0.127906976744186	TRUE	TRUE
ENSG00000160505.16	.	BCM	GRCh38.p13	chr19	55858160	55858160	+	C	C	T	Missense_Mutation	SNP	ENST00000301295.11	exon3	c.C767T	p.P256L	exonic	ENSG00000160505.16	.	nonsynonymous SNV	ENSG00000160505.16:ENST00000301295.11:exon3:c.C767T:p.P256L	19q13.43	C3L-02809	1.648e-05	0	0	0	0	2.997e-05	0	0	rs749461870	9.19	D	D	D	D	.	N	M	T	D	0.361	T	D	D	0.361	0.824	0.911	0.293	T	T	T	T	D	T	2.859	23.100	0.998	N	N	0.272	3.637	0.025	2.447	0.997	0.560	0.624	0.574	0.564	.	4.100	4.100	6.128	0.007	-0.176	0.457	0.002	0.001	895	NACHT_nucleoside_triphosphatase	.	.	ID=COSV56722459;OCCURENCE=1(large_intestine)	NLRP4	309	0	339	67	0.165024630541872	TRUE	TRUE
ENSG00000179709.8	.	BCM	GRCh38.p13	chr19	55962194	55962194	+	G	G	A	Missense_Mutation	SNP	ENST00000291971.7	exon4	c.G2170A	p.A724T	exonic	ENSG00000179709.8	.	nonsynonymous SNV	ENSG00000179709.8:ENST00000291971.7:exon4:c.G2170A:p.A724T	19q13.43	C3L-02809	0.0003	0	0	0.0032	0	2.999e-05	0	6.064e-05	rs199475840	2.19	T	D	B	B	.	N	N	D	N	0.126	T	T	T	0.168	.	0.272	0.067	T	T	T	T	T	T	-0.444	0.155	0.596	N	N	-1.499	0.081	-1.656	0.061	0.000	0.487	0.574	0.574	0.564	.	1.930	-3.870	-1.832	-0.854	-0.833	0.000	0.001	0.000	946	.	.	.	ID=COSV52583220;OCCURENCE=1(oesophagus),1(ovary)	NLRP8	156	0	176	54	0.234782608695652	TRUE	TRUE
ENSG00000125885.13	.	BCM	GRCh38.p13	chr20	5993621	5993621	+	G	G	A	Missense_Mutation	SNP	ENST00000610722.4	exon18	c.G2356A	p.V786I	exonic	ENSG00000125885.13;ENSG00000286235.1	.	nonsynonymous SNV	ENSG00000125885.13:ENST00000610722.4:exon18:c.G2356A:p.V786I,ENSG00000286235.1:ENST00000652720.1:exon18:c.G2356A:p.V786I	20p12.3	C3L-02809	.	.	.	.	.	.	.	.	rs768013365	0.20	T	T	B	B	N	N	N	T	N	0.088	T	T	T	0.099	0.446	0.221	0.106	T	T	T	T	T	T	1.441	15.350	0.854	N	N	-0.707	0.802	-0.433	1.314	0.558	0.732	0.744	0.609	0.684	.	5.820	4.730	1.790	0.308	-0.063	0.852	1.000	0.987	659	.	.	.	ID=COSV54511561;OCCURENCE=1(central_nervous_system),1(upper_aerodigestive_tract),1(endometrium)	MCM8	90	0	97	30	0.236220472440945	TRUE	TRUE
ENSG00000101331.17	.	BCM	GRCh38.p13	chr20	32015030	32015030	+	C	C	A	Missense_Mutation	SNP	ENST00000452892.3	exon2	c.C157A	p.P53T	exonic	ENSG00000101331.17	.	nonsynonymous SNV	ENSG00000101331.17:ENST00000452892.3:exon2:c.C157A:p.P53T	20q11.21	C3L-02809	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	M	T	D	0.926	D	D	D	0.676	0.589	0.674	0.131	T	.	D	D	D	D	3.705	25.400	0.998	D	D	0.789	8.577	0.728	8.313	1.000	0.563	0.563	0.658	0.636	.	4.530	4.530	7.264	1.026	0.599	1.000	1.000	0.999	500	.	.	.	.	CCM2L	60	0	107	20	0.15748031496063	TRUE	TRUE
ENSG00000169184.6	.	BCM	GRCh38.p13	chr22	27799629	27799629	+	C	C	G	Missense_Mutation	SNP	ENST00000302326.5	exon1	c.G915C	p.Q305H	exonic	ENSG00000169184.6	.	nonsynonymous SNV	ENSG00000169184.6:ENST00000302326.5:exon1:c.G915C:p.Q305H	22q12.1	C3L-02809	.	.	.	.	.	.	.	.	.	4.19	T	D	P	P	.	D	N	T	N	0.236	T	T	D	0.109	0.139	0.762	.	T	T	T	T	T	T	2.164	20.600	0.859	D	N	-0.151	2.018	-0.089	2.079	1.000	0.455	0.547	0.607	0.555	.	4.880	3.860	0.943	0.710	0.448	0.980	0.943	0.844	982	.	.	.	.	MN1	180	0	213	20	0.0858369098712446	TRUE	TRUE
ENSG00000128268.12	.	BCM	GRCh38.p13	chr22	39488318	39488318	+	G	G	A	Missense_Mutation	SNP	ENST00000341184.7	exon2	c.G971A	p.R324H	exonic	ENSG00000128268.12	.	nonsynonymous SNV	ENSG00000128268.12:ENST00000341184.7:exon2:c.G971A:p.R324H	22q13.1	C3L-02809	8.403e-06	9.944e-05	0	0	0	0	0	0	rs747893252	7.19	D	T	P	B	D	D	L	.	D	0.139	T	T	T	0.117	0.640	0.227	1.566	T	D	T	T	T	D	2.737	22.900	0.998	D	N	0.419	4.464	0.468	4.884	1.000	0.701	0.702	0.717	0.563	.	5.370	5.370	5.062	1.172	0.672	1.000	0.721	0.966	906	.	.	.	ID=COSV100361829;OCCURENCE=1(endometrium)	MGAT3	291	0	314	45	0.125348189415042	TRUE	NA
ENSG00000147162.14	.	BCM	GRCh38.p13	chrX	71563398	71563398	+	A	A	G	Missense_Mutation	SNP	ENST00000373719.8	exon18	c.A2335G	p.M779V	exonic	ENSG00000147162.14	.	nonsynonymous SNV	ENSG00000147162.14:ENST00000373719.8:exon18:c.A2335G:p.M779V	Xq13.1	C3L-02809	.	.	.	.	.	.	.	.	.	7.19	T	T	B	B	D	D	N	T	N	0.535	T	T	D	0.363	0.348	0.977	1.452	T	T	D	T	D	D	1.813	17.820	0.444	D	.	.	.	.	.	1.000	.	.	.	.	.	5.340	5.340	9.112	1.312	0.754	1.000	1.000	1.000	314	O-GlcNAc_transferase,_C-terminal	.	.	ID=COSV65481612;OCCURENCE=1(upper_aerodigestive_tract)	OGT	69	0	47	36	0.433734939759036	TRUE	TRUE
ENSG00000162385.11	.	BCM	GRCh38.p13	chr1	53233574	53233574	+	A	A	G	Silent	SNP	ENST00000371470.8	exon3	c.T226C	p.L76L	exonic	ENSG00000162385.11	.	synonymous SNV	ENSG00000162385.11:ENST00000371470.8:exon3:c.T226C:p.L76L	1p32.3	C3L-02809	8.24e-06	0	0	0	0	0	0	6.06e-05	rs368006653	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAGOH	222	0	238	21	0.0810810810810811	TRUE	NA
ENSG00000162595.7	.	BCM	GRCh38.p13	chr1	68047181	68047181	+	G	G	A	Silent	SNP	ENST00000370981.3	exon4	c.C117T	p.R39R	exonic	ENSG00000162595.7	.	synonymous SNV	ENSG00000162595.7:ENST00000370981.3:exon4:c.C117T:p.R39R	1p31.3	C3L-02809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63970826;OCCURENCE=1(liver)	DIRAS3	437	0	413	57	0.121276595744681	TRUE	TRUE
ENSG00000189030.10	.	BCM	GRCh38.p13	chr1	156299169	156299169	+	G	G	A	Silent	SNP	ENST00000339922.5	exon1	c.C21T	p.N7N	exonic	ENSG00000189030.10	.	synonymous SNV	ENSG00000189030.10:ENST00000339922.5:exon1:c.C21T:p.N7N	1q22	C3L-02809	.	.	.	.	.	.	.	.	rs138677254	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VHLL	74	0	54	10	0.15625	TRUE	NA
ENSG00000143199.18	.	BCM	GRCh38.p13	chr1	167823060	167823060	+	G	G	T	Silent	SNP	ENST00000367851.9	exon29	c.C4116A	p.I1372I	exonic	ENSG00000143199.18	.	synonymous SNV	ENSG00000143199.18:ENST00000367851.9:exon29:c.C4116A:p.I1372I	1q24.2	C3L-02809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADCY10	544	0	493	175	0.261976047904192	TRUE	TRUE
ENSG00000172752.14	.	BCM	GRCh38.p13	chr3	130440665	130440665	+	C	C	T	Silent	SNP	ENST00000265379.10	exon36	c.C6315T	p.Y2105Y	exonic	ENSG00000172752.14	.	synonymous SNV	ENSG00000172752.14:ENST00000265379.10:exon36:c.C6315T:p.Y2105Y	3q22.1	C3L-02809	0.0003	0.0002	0.0006	0	0	0.0001	0	0.0013	rs374598016	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55206059;OCCURENCE=1(skin)	COL6A5	350	0	296	45	0.131964809384164	TRUE	TRUE
ENSG00000113212.7	.	BCM	GRCh38.p13	chr5	141174929	141174929	+	C	C	G	Silent	SNP	ENST00000231137.6	exon1	c.C2094G	p.L698L	exonic	ENSG00000113212.7	.	synonymous SNV	ENSG00000113212.7:ENST00000231137.6:exon1:c.C2094G:p.L698L	5q31.3	C3L-02809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHB7	1486	0	1481	99	0.0626582278481013	NA	TRUE
ENSG00000226490.2	.	BCM	GRCh38.p13	chr8	141518472	141518472	+	C	C	T	Silent	SNP	ENST00000643770.1	exon2	c.C336T	p.P112P	exonic	ENSG00000226490.2	.	synonymous SNV	ENSG00000226490.2:ENST00000643770.1:exon2:c.C336T:p.P112P	8q24.3	C3L-02809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC138647.1	172	0	254	35	0.121107266435986	TRUE	NA
ENSG00000154118.13	.	BCM	GRCh38.p13	chr16	87689836	87689836	+	C	C	T	Silent	SNP	ENST00000284262.3	exon4	c.C1476T	p.P492P	exonic	ENSG00000154118.13	.	synonymous SNV	ENSG00000154118.13:ENST00000284262.3:exon4:c.C1476T:p.P492P	16q24.2	C3L-02809	0.0005	0	0	0	0	0	0	0.0027	rs537678092	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	JPH3	106	0	91	67	0.424050632911392	TRUE	NA
ENSG00000184185.10	.	BCM	GRCh38.p13	chr17	21415396	21415396	+	C	C	T	Silent	SNP	ENST00000583088.6	exon3	c.C54T	p.D18D	exonic	ENSG00000184185.10	.	synonymous SNV	ENSG00000184185.10:ENST00000583088.6:exon3:c.C54T:p.D18D	17p11.2	C3L-02809	3.31e-05	0	0	0.0001	0	0	0	0.0002	rs781815544	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59163119;OCCURENCE=1(biliary_tract),1(stomach)	KCNJ12	510	1	567	38	0.0628099173553719	NA	TRUE
ENSG00000161681.15	.	BCM	GRCh38.p13	chr19	50703682	50703682	+	C	C	T	Silent	SNP	ENST00000293441.5	exon10	c.G1371A	p.A457A	exonic	ENSG00000161681.15	.	synonymous SNV	ENSG00000161681.15:ENST00000293441.5:exon10:c.G1371A:p.A457A	19q13.33	C3L-02809	.	.	.	.	.	.	.	.	rs1007850886	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SHANK1	104	0	111	21	0.159090909090909	TRUE	NA
ENSG00000142173.16	.	BCM	GRCh38.p13	chr21	46132366	46132366	+	C	C	T	Silent	SNP	ENST00000300527.9	exon28	c.C2874T	p.H958H	exonic	ENSG00000142173.16	.	synonymous SNV	ENSG00000142173.16:ENST00000300527.9:exon28:c.C2874T:p.H958H	21q22.3	C3L-02809	2.564e-05	0.0002	0	0	0	1.562e-05	0	0	rs765550338	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99385721;OCCURENCE=1(stomach)	COL6A2	388	0	273	81	0.228813559322034	TRUE	NA
ENSG00000100364.18	.	BCM	GRCh38.p13	chr22	45202996	45202996	+	G	G	A	Silent	SNP	ENST00000336156.9	exon7	c.C846T	p.H282H	exonic	ENSG00000100364.18	.	synonymous SNV	ENSG00000100364.18:ENST00000336156.9:exon7:c.C846T:p.H282H	22q13.31	C3L-02809	2.578e-05	0	0	0	0	4.629e-05	0	0	rs372186039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99326138;OCCURENCE=2(large_intestine)	KIAA0930	81	0	75	14	0.157303370786517	TRUE	TRUE
ENSG00000138430.16	.	BCM	GRCh38.p13	chr2	174247725	174247729	+	CTCAT	CTCAT	-	Intron	DEL	NA	NA	NA	NA	intronic	ENSG00000138430.16	.	.	.	2q31.1	C3L-02809	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OLA1	350	1	294	70	0.192307692307692	TRUE	TRUE
ENSG00000135424.18	.	BCM	GRCh38.p13	chr12	55686217	55686217	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000135424.18	.	.	.	12q13.2	C3L-02809	.	.	.	.	.	.	.	.	.	3.9	D	.	.	.	.	D	.	.	N	.	T	T	T	0.086	0.363	.	.	.	.	.	.	.	T	2.225	21.100	0.997	D	N	0.102	2.895	0.145	2.925	0.991	0.497	0.547	0.537	0.542	.	5.470	3.600	2.381	1.026	0.599	0.997	0.998	0.999	748	.	.	.	.	ITGA7	226	1	260	79	0.233038348082596	TRUE	TRUE
ENSG00000116254.18	.	BCM	GRCh38.p13	chr1	6130220	6130220	+	G	G	A	Missense_Mutation	SNP	ENST00000262450.8	exon22	c.C3371T	p.P1124L	exonic	ENSG00000116254.18	.	nonsynonymous SNV	ENSG00000116254.18:ENST00000262450.8:exon22:c.C3371T:p.P1124L	1p36.31	C3N-02768	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.919	D	D	D	0.938	0.862	0.939	2.459	D	D	D	D	D	D	4.513	32	0.999	D	D	0.992	13.661	0.894	13.489	1.000	0.646	0.547	0.645	0.563	.	4.810	4.810	9.899	1.176	0.676	1.000	0.996	0.981	873	Helicase,_C-terminal	.	.	.	CHD5	145	0	201	28	0.122270742358079	TRUE	TRUE
ENSG00000142599.19	.	BCM	GRCh38.p13	chr1	8365899	8365899	+	G	G	A	Missense_Mutation	SNP	ENST00000400908.7	exon13	c.C1360T	p.R454C	exonic	ENSG00000142599.19	.	nonsynonymous SNV	ENSG00000142599.19:ENST00000400908.7:exon13:c.C1360T:p.R454C	1p36.23	C3N-02768	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	.	D	M	T	D	0.882	T	T	D	0.549	0.559	0.818	2.297	D	D	D	D	D	D	4.741	32	0.999	D	D	0.934	11.974	0.942	15.669	1.000	0.672	0.702	0.702	0.711	.	5.970	5.970	10.003	1.176	0.676	1.000	1.000	0.991	840	.	.	.	.	RERE	341	0	395	61	0.133771929824561	TRUE	NA
ENSG00000058668.14	.	BCM	GRCh38.p13	chr1	203707953	203707953	+	C	C	T	Missense_Mutation	SNP	ENST00000357681.9	exon10	c.C1406T	p.T469M	exonic	ENSG00000058668.14	.	nonsynonymous SNV	ENSG00000058668.14:ENST00000357681.9:exon10:c.C1406T:p.T469M	1q32.1	C3N-02768	8.237e-06	0	0	0	0	0	0	6.056e-05	rs778946356	18.19	D	D	D	D	D	D	H	D	D	0.912	D	D	D	0.952	0.856	0.958	1.315	T	.	D	D	D	D	4.029	27.200	0.999	D	D	1.061	15.969	0.949	16.008	1.000	0.732	0.588	0.744	0.714	.	5.540	5.540	7.874	1.026	0.599	1.000	0.838	0.992	586	.	.	.	.	ATP2B4	462	0	589	66	0.100763358778626	TRUE	NA
ENSG00000181873.13	.	BCM	GRCh38.p13	chr1	228174865	228174865	+	C	C	A	Missense_Mutation	SNP	ENST00000366711.4	exon2	c.C515A	p.A172D	exonic	ENSG00000181873.13	.	nonsynonymous SNV	ENSG00000181873.13:ENST00000366711.4:exon2:c.C515A:p.A172D	1q42.13	C3N-02768	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.294	T	T	T	0.047	0.542	0.088	0.388	T	T	T	T	T	T	0.719	8.629	0.472	N	N	-1.267	0.184	-1.257	0.239	1.000	0.672	0.702	0.460	0.636	.	4.650	2.730	0.166	0.138	-0.165	0.000	0.000	0.000	540	.	.	.	ID=COSV64511631;OCCURENCE=2(thyroid)	IBA57	144	0	234	43	0.155234657039711	TRUE	TRUE
ENSG00000169432.18	.	BCM	GRCh38.p13	chr2	166198901	166198901	+	G	G	A	Missense_Mutation	SNP	ENST00000642356.2	exon27	c.C5738T	p.S1913L	exonic	ENSG00000169432.18	.	nonsynonymous SNV	ENSG00000169432.18:ENST00000642356.2:exon27:c.C5738T:p.S1913L	2q24.3	C3N-02768	.	.	.	.	.	.	.	.	.	15.18	D	D	.	.	N	D	M	D	D	0.264	T	D	D	0.550	0.407	0.862	0.104	T	D	D	D	D	D	3.121	23.700	0.997	D	D	0.260	3.582	0.406	4.404	0.556	0.581	0.574	0.565	0.621	.	6.080	6.080	4.224	1.176	0.618	1.000	1.000	0.996	346	.	.	.	.	SCN9A	287	0	351	28	0.0738786279683377	TRUE	NA
ENSG00000213672.8	.	BCM	GRCh38.p13	chr3	48682483	48682483	+	C	C	A	Missense_Mutation	SNP	ENST00000294129.7	exon3	c.G351T	p.M117I	exonic	ENSG00000213672.8	.	nonsynonymous SNV	ENSG00000213672.8:ENST00000294129.7:exon3:c.G351T:p.M117I	3p21.31	C3N-02768	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	U	N	N	T	N	0.310	T	T	T	0.037	0.394	0.284	0.148	T	T	T	T	T	D	1.606	16.410	0.981	D	N	-0.341	1.517	-0.193	1.803	1.000	0.707	0.725	0.702	0.714	.	4.720	3.820	1.220	0.952	0.599	1.000	0.543	0.970	2	.	.	.	.	NCKIPSD	386	0	430	47	0.0985324947589098	TRUE	TRUE
ENSG00000138468.16	.	BCM	GRCh38.p13	chr3	101337518	101337518	+	G	G	A	Missense_Mutation	SNP	ENST00000394095.7	exon17	c.C2471T	p.P824L	exonic	ENSG00000138468.16	.	nonsynonymous SNV	ENSG00000138468.16:ENST00000394095.7:exon17:c.C2471T:p.P824L	3q12.3	C3N-02768	.	.	.	.	.	.	.	.	.	5.20	T	T	P	B	N	D	L	T	D	0.080	T	T	T	0.057	0.504	0.162	1.690	T	T	T	T	D	D	2.871	23.200	0.985	D	N	0.159	3.125	0.311	3.784	0.906	0.651	0.670	0.618	0.684	.	5.680	4.800	3.095	1.176	0.676	1.000	1.000	1.000	278	Ulp1_protease_family,_C-terminal_catalytic_domain	.	.	.	SENP7	34	0	65	8	0.10958904109589	TRUE	TRUE
ENSG00000078177.14	.	BCM	GRCh38.p13	chr4	40120372	40120372	+	A	A	G	Missense_Mutation	SNP	ENST00000261435.11	exon9	c.A2261G	p.E754G	exonic	ENSG00000078177.14	.	nonsynonymous SNV	ENSG00000078177.14:ENST00000261435.11:exon9:c.A2261G:p.E754G	4p14	C3N-02768	.	.	.	.	.	.	.	.	.	4.20	D	D	B	B	N	N	L	T	D	0.068	T	T	T	0.068	0.206	0.463	0.093	T	T	T	T	T	T	2.262	21.300	0.992	D	N	-0.048	2.344	-0.077	2.112	1.000	0.653	0.634	0.676	0.655	.	5.260	5.260	1.082	1.298	0.756	0.943	0.123	0.164	428	.	.	.	.	N4BP2	152	0	151	26	0.146892655367232	TRUE	TRUE
ENSG00000109654.15	.	BCM	GRCh38.p13	chr4	153294456	153294456	+	T	T	G	Missense_Mutation	SNP	ENST00000437508.6	exon5	c.T676G	p.L226V	exonic	ENSG00000109654.15	.	nonsynonymous SNV	ENSG00000109654.15:ENST00000437508.6:exon5:c.T676G:p.L226V	4q31.3	C3N-02768	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	D	D	M	T	N	0.550	T	T	T	0.184	0.358	0.357	1.259	D	T	T	T	D	D	1.740	17.300	0.994	D	N	-0.297	1.621	-0.148	1.916	0.999	0.732	0.590	0.744	0.655	.	6.170	3.530	3.116	-0.224	-0.187	1.000	0.990	0.993	605	B-box,_C-terminal	.	.	.	TRIM2	120	0	145	21	0.126506024096386	TRUE	TRUE
ENSG00000112182.15	.	BCM	GRCh38.p13	chr6	89950623	89950623	+	G	G	A	Missense_Mutation	SNP	ENST00000257749.9	exon7	c.C1483T	p.R495W	exonic	ENSG00000112182.15	.	nonsynonymous SNV	ENSG00000112182.15:ENST00000257749.9:exon7:c.C1483T:p.R495W	6q15	C3N-02768	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	N	D	M	T	N	0.887	T	T	D	0.360	.	0.430	1.465	D	T	D	T	D	D	3.593	25.000	0.999	D	D	0.157	3.117	0.151	2.953	1.000	0.554	0.590	0.618	0.586	.	5.210	3.410	2.062	0.209	-0.130	1.000	0.997	0.997	809	.	.	.	ID=COSV57588264;OCCURENCE=1(prostate)	BACH2	163	0	217	24	0.0995850622406639	TRUE	TRUE
ENSG00000164542.12	.	BCM	GRCh38.p13	chr7	36326855	36326855	+	G	G	A	Missense_Mutation	SNP	ENST00000297063.10	exon7	c.C1468T	p.H490Y	exonic	ENSG00000164542.12	.	nonsynonymous SNV	ENSG00000164542.12:ENST00000297063.10:exon7:c.C1468T:p.H490Y	7p14.2	C3N-02768	.	.	.	.	.	.	.	.	.	11.19	T	D	D	P	D	D	M	.	D	0.598	T	T	T	0.308	0.567	0.242	1.013	T	T	D	T	D	D	3.427	24.500	0.997	D	D	0.611	6.035	0.627	6.581	0.999	0.554	0.588	0.547	0.621	.	5.500	4.620	9.424	1.176	0.676	1.000	0.998	0.996	917	.	.	.	.	KIAA0895	249	0	328	51	0.134564643799472	TRUE	TRUE
ENSG00000002746.15	.	BCM	GRCh38.p13	chr7	43311916	43311916	+	G	G	A	Missense_Mutation	SNP	ENST00000395891.7	exon4	c.G181A	p.V61I	exonic	ENSG00000002746.15	.	nonsynonymous SNV	ENSG00000002746.15:ENST00000395891.7:exon4:c.G181A:p.V61I	7p13	C3N-02768	3.314e-05	0	0	0	0	0	0.0011	0.0002	rs770727253	1.20	T	T	B	B	N	N	L	T	N	0.187	T	T	T	0.044	0.083	0.202	0.402	T	T	T	T	T	T	1.691	16.960	0.992	D	N	-0.463	1.250	-0.341	1.483	0.992	0.615	0.547	0.659	0.564	.	5.760	3.250	3.055	0.245	0.676	0.997	0.438	0.960	929	.	.	.	ID=COSV67836527;OCCURENCE=1(breast),1(oesophagus),1(stomach),1(pancreas)	HECW1	331	0	492	52	0.0955882352941176	TRUE	TRUE
ENSG00000205277.9	.	BCM	GRCh38.p13	chr7	101006557	101006557	+	G	G	T	Nonsense_Mutation	SNP	ENST00000379442.7	exon6	c.G15472T	p.E5158X	exonic	ENSG00000205277.9	.	stopgain	ENSG00000205277.9:ENST00000379442.7:exon6:c.G15472T:p.E5158X	7q22.1	C3N-02768	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	A	.	.	.	0.561	.	.	.	.	.	.	.	.	.	D	D	.	.	8.194	41	0.972	N	N	0.073	2.779	-0.347	1.470	0.000	0.554	0.574	0.602	0.542	.	2.990	0.773	0.571	0.111	0.597	0.007	0.019	0.034	818	.	.	.	.	MUC12	148	0	175	42	0.193548387096774	TRUE	TRUE
ENSG00000196456.13	.	BCM	GRCh38.p13	chr7	150397503	150397503	+	A	A	T	Missense_Mutation	SNP	ENST00000329630.10	exon3	c.A1022T	p.H341L	exonic	ENSG00000196456.13	.	nonsynonymous SNV	ENSG00000196456.13:ENST00000329630.10:exon3:c.A1022T:p.H341L	7q36.1	C3N-02768	.	.	.	.	.	.	.	.	.	4.19	D	T	B	B	.	N	N	T	D	0.218	T	T	D	0.036	0.521	0.242	1.182	D	T	T	T	T	T	0.815	9.541	0.945	N	N	-1.037	0.366	-0.975	0.521	0.989	0.651	0.654	0.780	0.684	.	3.780	-0.251	0.514	-1.220	0.552	0.000	0.010	0.959	929	Zinc_finger_C2H2-type	.	.	.	ZNF775	524	0	759	84	0.099644128113879	TRUE	TRUE
ENSG00000106565.18	.	BCM	GRCh38.p13	chr7	150793202	150793218	+	AGTGTCGATGTATAAAA	AGTGTCGATGTATAAAA	-	Frame_Shift_Del	DEL	ENST00000326442.10	exon5	c.470_486del	p.F157Cfs*3	exonic	ENSG00000106565.18	.	frameshift deletion	ENSG00000106565.18:ENST00000326442.10:exon5:c.470_486del:p.F157Cfs*3	7q36.1	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM176B	697	0	927	87	0.0857988165680473	TRUE	TRUE
ENSG00000261150.3	.	BCM	GRCh38.p13	chr8	143867291	143867291	+	G	G	C	Missense_Mutation	SNP	ENST00000615648.2	exon2	c.C5963G	p.P1988R	exonic	ENSG00000261150.3	.	nonsynonymous SNV	ENSG00000261150.3:ENST00000615648.2:exon2:c.C5963G:p.P1988R	8q24.3	C3N-02768	.	.	.	.	.	.	.	.	.	6.14	.	T	.	.	.	D	L	.	.	0.216	T	T	D	0.325	0.640	0.675	.	T	T	T	T	D	D	3.055	23.500	0.996	D	D	0.156	3.114	0.093	2.708	1.000	0.696	0.610	0.723	0.563	.	4.760	4.760	4.673	1.176	0.618	0.989	0.002	0.002	964	.	.	.	.	EPPK1	194	0	381	44	0.103529411764706	TRUE	TRUE
ENSG00000197694.18	.	BCM	GRCh38.p13	chr9	128627404	128627404	+	C	C	T	Nonsense_Mutation	SNP	ENST00000372731.8	exon49	c.C6580T	p.Q2194X	exonic	ENSG00000197694.18	.	stopgain	ENSG00000197694.18:ENST00000372731.8:exon49:c.C6580T:p.Q2194X	9q34.11	C3N-02768	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.461	.	.	.	.	.	.	.	.	.	D	D	.	.	9.062	47	0.997	D	N	1.078	16.613	0.936	15.396	1.000	0.672	0.702	0.702	0.711	.	5.400	5.400	7.510	0.966	0.530	1.000	0.996	0.896	352	.	.	.	.	SPTAN1	204	0	169	88	0.342412451361868	TRUE	TRUE
ENSG00000151655.19	.	BCM	GRCh38.p13	chr10	7731929	7731929	+	T	T	C	Missense_Mutation	SNP	ENST00000358415.9	exon13	c.T1580C	p.I527T	exonic	ENSG00000151655.19	.	nonsynonymous SNV	ENSG00000151655.19:ENST00000358415.9:exon13:c.T1580C:p.I527T	10p14	C3N-02768	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.920	T	T	D	0.495	0.711	0.476	0.475	T	T	D	T	D	D	4.128	28.000	0.998	D	D	0.818	9.152	0.753	8.866	1.000	0.487	0.574	0.574	0.564	.	5.440	5.440	7.434	1.126	0.654	1.000	0.999	0.979	917	.	.	.	.	ITIH2	148	0	212	33	0.13469387755102	TRUE	TRUE
ENSG00000176273.15	.	BCM	GRCh38.p13	chr10	93894197	93894197	+	C	C	T	Missense_Mutation	SNP	ENST00000427197.2	exon1	c.C164T	p.S55F	exonic	ENSG00000176273.15	.	nonsynonymous SNV	ENSG00000176273.15:ENST00000427197.2:exon1:c.C164T:p.S55F	10q23.33	C3N-02768	.	.	.	.	.	.	.	.	.	3.20	D	D	B	B	N	N	L	T	N	0.163	T	T	D	0.213	0.522	0.103	0.263	T	T	T	T	T	T	1.192	13.580	0.930	N	N	-0.692	0.827	-0.752	0.825	1.000	0.267	0.219	0.520	0.250	.	3.640	2.720	0.470	0.930	0.467	0.016	0.035	0.006	234	.	.	.	.	SLC35G1	110	0	151	12	0.0736196319018405	TRUE	NA
ENSG00000148965.10	.	BCM	GRCh38.p13	chr11	18231580	18231580	+	G	G	T	Missense_Mutation	SNP	ENST00000278222.7	exon4	c.C315A	p.N105K	exonic	ENSG00000148965.10;ENSG00000255071.3	.	nonsynonymous SNV	ENSG00000148965.10:ENST00000278222.7:exon4:c.C315A:p.N105K,ENSG00000255071.3:ENST00000524555.3:exon6:c.C549A:p.N183K	11p15.1	C3N-02768	2.472e-05	0	0	0	0.0002	2.998e-05	0	0	rs541989724	2.19	D	D	P	P	.	N	L	T	N	0.274	T	T	T	0.145	0.655	0.048	0.389	T	T	T	T	T	T	1.440	15.350	0.871	N	N	-0.839	0.600	-1.010	0.476	0.309	0.554	0.547	0.602	0.564	.	3.260	-1.490	0.873	-0.861	-1.131	0.950	0.000	0.000	862	.	.	.	.	SAA4	315	0	340	115	0.252747252747253	TRUE	TRUE
ENSG00000179292.5	.	BCM	GRCh38.p13	chr11	66295013	66295013	+	G	G	A	Missense_Mutation	SNP	ENST00000327259.5	exon2	c.G767A	p.R256H	exonic	ENSG00000179292.5	.	nonsynonymous SNV	ENSG00000179292.5:ENST00000327259.5:exon2:c.G767A:p.R256H	11q13.2	C3N-02768	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	L	.	D	0.610	T	T	D	0.487	0.736	0.291	.	T	T	D	D	D	D	4.442	31	0.999	D	D	0.818	9.138	0.756	8.933	1.000	0.646	0.610	0.645	0.563	.	4.210	4.210	9.685	1.168	0.670	1.000	1.000	0.998	91	.	.	.	ID=COSV59174702;OCCURENCE=1(large_intestine),1(lung)	TMEM151A	394	0	640	69	0.0973201692524683	TRUE	TRUE
ENSG00000172830.13	.	BCM	GRCh38.p13	chr11	67310084	67310084	+	G	G	A	Nonsense_Mutation	SNP	ENST00000308127.9	exon13	c.G1428A	p.W476X	exonic	ENSG00000172830.13	.	stopgain	ENSG00000172830.13:ENST00000308127.9:exon13:c.G1428A:p.W476X	11q13.2	C3N-02768	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.047	.	.	.	.	.	.	.	.	.	D	D	.	.	7.804	39	0.988	D	N	0.755	7.970	0.613	6.389	1.000	0.706	0.547	0.710	0.636	.	4.650	4.650	3.675	1.176	0.676	1.000	1.000	0.997	397	.	.	.	.	SSH3	149	0	149	72	0.32579185520362	TRUE	TRUE
ENSG00000186174.12	.	BCM	GRCh38.p13	chr11	118900819	118900819	+	G	G	A	Missense_Mutation	SNP	ENST00000334801.7	exon6	c.C2924T	p.S975L	exonic	ENSG00000186174.12	.	nonsynonymous SNV	ENSG00000186174.12:ENST00000334801.7:exon6:c.C2924T:p.S975L	11q23.3	C3N-02768	2.478e-05	0	8.64e-05	0	0	3.005e-05	0	0	rs147776799	14.20	D	D	D	D	D	D	M	T	D	0.839	T	T	D	0.391	.	0.393	0.732	T	D	T	T	D	D	4.042	27.300	0.999	D	D	0.694	7.043	0.704	7.822	1.000	0.707	0.577	0.696	0.714	.	5.110	5.110	7.763	1.176	0.676	1.000	0.937	0.971	463	.	.	.	ID=COSV52689604;OCCURENCE=1(skin)	BCL9L	142	0	136	88	0.392857142857143	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3N-02768	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	280	0	337	148	0.305154639175258	TRUE	TRUE
ENSG00000135503.13	.	BCM	GRCh38.p13	chr12	51981034	51981034	+	G	G	A	Missense_Mutation	SNP	ENST00000257963.9	exon4	c.G646A	p.G216S	exonic	ENSG00000135503.13	.	nonsynonymous SNV	ENSG00000135503.13:ENST00000257963.9:exon4:c.G646A:p.G216S	12q13.13	C3N-02768	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.963	D	D	D	0.942	0.817	0.985	2.167	D	T	D	D	D	D	4.351	30	0.999	D	D	1.108	17.872	1.003	19.039	1.000	0.732	0.590	0.744	0.662	.	5.120	5.120	10.003	1.176	0.674	1.000	1.000	0.996	661	Protein_kinase_domain;Protein_kinase,_ATP_binding_site	.	.	ID=COSV57777072;OCCURENCE=2(large_intestine),1(endometrium)	ACVR1B	124	0	141	28	0.165680473372781	TRUE	TRUE
ENSG00000139648.7	.	BCM	GRCh38.p13	chr12	52548744	52548744	+	G	G	A	Missense_Mutation	SNP	ENST00000267119.6	exon4	c.C770T	p.S257F	exonic	ENSG00000139648.7	.	nonsynonymous SNV	ENSG00000139648.7:ENST00000267119.6:exon4:c.C770T:p.S257F	12q13.13	C3N-02768	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	N	N	H	D	D	0.346	D	D	D	0.452	0.513	0.935	0.106	T	D	T	D	D	D	3.429	24.500	0.998	N	N	0.473	4.833	0.317	3.816	0.949	0.497	0.590	0.547	0.542	.	4.450	4.450	0.260	1.176	0.676	0.000	1.000	0.985	856	Intermediate_filament,_rod_domain	.	.	.	KRT71	323	0	449	53	0.105577689243028	TRUE	NA
ENSG00000152137.7	.	BCM	GRCh38.p13	chr12	119179398	119179398	+	G	G	A	Missense_Mutation	SNP	ENST00000281938.7	exon1	c.G86A	p.R29H	exonic	ENSG00000152137.7	.	nonsynonymous SNV	ENSG00000152137.7:ENST00000281938.7:exon1:c.G86A:p.R29H	12q24.23	C3N-02768	.	.	.	.	.	.	.	.	.	16.20	D	D	D	P	D	D	M	D	D	0.720	D	D	D	0.759	0.445	0.996	0.799	T	T	D	D	D	T	4.390	31	1.000	D	D	0.518	5.180	0.525	5.392	1.000	0.767	0.563	0.851	0.639	.	4.420	4.420	9.151	1.083	0.676	1.000	0.999	0.995	964	.	.	.	ID=COSV56139133;OCCURENCE=1(large_intestine)	HSPB8	572	0	619	198	0.24235006119951	TRUE	NA
ENSG00000139364.10	.	BCM	GRCh38.p13	chr12	125653844	125653844	+	C	C	A	Missense_Mutation	SNP	ENST00000299308.7	exon9	c.C2371A	p.P791T	exonic	ENSG00000139364.10	.	nonsynonymous SNV	ENSG00000139364.10:ENST00000299308.7:exon9:c.C2371A:p.P791T	12q24.32	C3N-02768	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	N	D	L	T	N	0.049	T	T	T	0.034	0.238	0.055	0.445	T	T	T	T	T	T	0.420	5.650	0.185	D	N	-0.383	1.421	-0.362	1.441	0.760	0.732	0.574	0.744	0.564	.	5.810	3.970	2.637	1.026	0.599	0.492	0.857	0.747	937	.	.	.	.	TMEM132B	395	0	467	44	0.086105675146771	TRUE	TRUE
ENSG00000184564.11	.	BCM	GRCh38.p13	chr13	85796175	85796175	+	C	C	A	Missense_Mutation	SNP	ENST00000647374.2	exon2	c.G334T	p.G112C	exonic	ENSG00000184564.11	.	nonsynonymous SNV	ENSG00000184564.11:ENST00000647374.2:exon2:c.G334T:p.G112C	13q31.1	C3N-02768	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	M	T	N	0.386	T	T	D	0.208	0.411	0.830	0.207	T	T	T	T	D	T	2.937	23.300	0.988	D	D	0.547	5.422	0.564	5.802	0.998	0.487	0.574	0.547	0.564	.	6.170	5.330	3.864	0.126	0.599	1.000	0.996	0.983	973	.	.	.	.	SLITRK6	141	0	145	17	0.104938271604938	TRUE	TRUE
ENSG00000184986.11	.	BCM	GRCh38.p13	chr14	105529349	105529349	+	G	G	A	Missense_Mutation	SNP	ENST00000392519.7	exon2	c.G515A	p.R172H	exonic	ENSG00000184986.11	.	nonsynonymous SNV	ENSG00000184986.11:ENST00000392519.7:exon2:c.G515A:p.R172H	14q32.33	C3N-02768	.	.	.	.	.	.	.	.	.	6.19	T	T	D	P	U	D	L	.	N	0.309	T	T	D	0.074	0.229	0.194	2.165	T	T	T	T	D	D	4.030	27.200	0.999	D	N	0.162	3.138	0.203	3.197	1.000	0.583	0.609	0.615	0.568	.	4.290	3.320	2.459	1.175	0.614	1.000	1.000	0.989	952	.	.	.	ID=COSV66796086;OCCURENCE=1(large_intestine),1(endometrium)	TMEM121	343	0	442	119	0.212121212121212	TRUE	TRUE
ENSG00000179938.12	.	BCM	GRCh38.p13	chr15	30089295	30089295	+	G	G	C	Missense_Mutation	SNP	ENST00000567927.1	exon11	c.G846C	p.R282S	exonic	ENSG00000179938.12	.	nonsynonymous SNV	ENSG00000179938.12:ENST00000567927.1:exon11:c.G846C:p.R282S	15q13.2	C3N-02768	.	.	.	.	.	.	.	.	.	4.15	T	D	.	.	.	N	M	T	D	0.104	T	T	T	0.026	.	0.081	2.121	.	T	T	T	D	.	1.633	16.590	0.967	N	N	-0.721	0.778	-0.935	0.573	0.000	0.554	0.588	0.618	0.621	.	1.480	0.478	0.329	-1.211	0.314	0.012	0.000	0.013	483	.	.	.	.	GOLGA8J	47	0	46	12	0.206896551724138	NA	TRUE
ENSG00000134152.11	.	BCM	GRCh38.p13	chr15	34152873	34152873	+	G	G	A	Nonsense_Mutation	SNP	ENST00000256544.8	exon4	c.C355T	p.R119X	exonic	ENSG00000134152.11	.	stopgain	ENSG00000134152.11:ENST00000256544.8:exon4:c.C355T:p.R119X	15q14	C3N-02768	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.384	.	.	.	.	.	.	.	.	.	D	D	.	.	6.687	36	0.997	D	N	0.719	7.393	0.546	5.605	0.998	0.732	0.654	0.725	0.728	.	5.470	2.510	3.945	1.155	0.676	1.000	1.000	0.998	659	.	.	.	.	KATNBL1	296	0	399	54	0.119205298013245	NA	TRUE
ENSG00000138622.4	.	BCM	GRCh38.p13	chr15	73343455	73343455	+	G	G	A	Missense_Mutation	SNP	ENST00000261917.4	exon2	c.C1139T	p.T380M	exonic	ENSG00000138622.4	.	nonsynonymous SNV	ENSG00000138622.4:ENST00000261917.4:exon2:c.C1139T:p.T380M	15q24.1	C3N-02768	.	.	.	.	.	.	.	.	.	19.19	D	D	D	D	.	D	M	D	D	0.653	D	D	D	0.889	0.561	0.998	1.721	D	D	D	D	D	D	4.090	27.700	0.999	D	D	0.853	9.899	0.851	11.808	1.000	0.707	0.574	0.725	0.564	.	5.340	5.340	9.866	1.157	0.654	1.000	0.979	0.992	635	Ion_transport_domain	.	.	ID=COSV56086245;OCCURENCE=3(large_intestine),1(pancreas),1(upper_aerodigestive_tract)	HCN4	261	0	347	48	0.121518987341772	TRUE	TRUE
ENSG00000169375.16	.	BCM	GRCh38.p13	chr15	75381635	75381635	+	G	G	A	Missense_Mutation	SNP	ENST00000394947.8	exon18	c.C3266T	p.S1089L	exonic	ENSG00000169375.16	.	nonsynonymous SNV	ENSG00000169375.16:ENST00000394947.8:exon18:c.C3266T:p.S1089L	15q24.2	C3N-02768	.	.	.	.	.	.	.	.	rs929890594	11.20	T	T	D	P	D	D	M	T	D	0.417	T	T	D	0.337	0.292	0.675	1.512	D	T	T	T	D	D	4.314	29.700	0.999	D	D	0.578	5.705	0.624	6.541	1.000	0.722	0.699	0.723	0.714	.	5.450	5.450	9.874	1.106	0.507	1.000	0.965	0.989	530	Sin3,_C-terminal	.	.	.	SIN3A	193	0	252	31	0.109540636042403	TRUE	NA
ENSG00000157766.18	.	BCM	GRCh38.p13	chr15	88847321	88847321	+	C	C	T	Missense_Mutation	SNP	ENST00000439576.7	exon8	c.C1508T	p.T503M	exonic	ENSG00000157766.18	.	nonsynonymous SNV	ENSG00000157766.18:ENST00000439576.7:exon8:c.C1508T:p.T503M	15q26.1	C3N-02768	3.587e-05	0	0	0	0	7.452e-05	0	0	rs779937883	7.19	D	D	D	P	.	N	L	T	D	0.520	T	T	T	0.161	0.577	0.043	0.205	T	T	T	T	D	D	3.285	24.100	0.993	D	N	0.453	4.692	0.424	4.536	0.921	0.581	0.574	0.576	0.613	.	5.540	5.540	4.998	1.012	0.583	0.997	0.383	0.200	969	Link_domain	.	.	ID=COSV100719479;OCCURENCE=1(stomach)	ACAN	208	0	276	35	0.112540192926045	TRUE	NA
ENSG00000169344.15	.	BCM	GRCh38.p13	chr16	20348877	20348877	+	G	G	A	Missense_Mutation	SNP	ENST00000302509.8	exon3	c.C424T	p.R142W	exonic	ENSG00000169344.15	.	nonsynonymous SNV	ENSG00000169344.15:ENST00000302509.8:exon3:c.C424T:p.R142W	16p12.3	C3N-02768	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	N	N	L	D	N	0.214	T	D	D	0.368	0.673	0.030	0.823	T	.	T	T	T	T	-0.420	0.175	0.810	N	N	-1.772	0.027	-1.941	0.018	1.000	0.526	0.616	0.596	0.584	.	5.450	-10.900	-3.370	-2.600	-0.948	0.000	0.000	0.029	829	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	UMOD	396	0	472	100	0.174825174825175	TRUE	NA
ENSG00000090863.12	.	BCM	GRCh38.p13	chr16	74457914	74457914	+	A	A	-	Frame_Shift_Del	DEL	ENST00000422840.7	exon24	c.3225delT	p.K1076Nfs*27	exonic	ENSG00000090863.12	.	frameshift deletion	ENSG00000090863.12:ENST00000422840.7:exon24:c.3225delT:p.K1076Nfs*27	16q23.1	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GLG1	176	0	247	15	0.0572519083969466	NA	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675137	7675137	+	C	C	G	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G475C	p.A159P	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G475C:p.A159P	17p13.1	C3N-02768	.	.	.	.	.	.	.	.	rs730882000	19.20	D	D	D	D	D	D	M	D	D	0.893	D	D	D	0.815	0.925	0.986	1.881	T	D	D	D	D	D	3.398	24.400	0.996	D	D	0.360	4.107	0.165	3.018	0.988	0.722	0.698	0.698	0.735	.	5.590	2.400	5.040	1.026	0.599	1.000	0.863	0.456	434	p53,_DNA-binding_domain	.	.	ID=COSV52661847;OCCURENCE=1(salivary_gland),2(breast),7(liver),2(oesophagus),5(large_intestine),1(central_nervous_system),2(biliary_tract),1(bone),3(haematopoietic_and_lymphoid_tissue),1(urinary_tract),1(kidney),1(pancreas),26(lung),1(thyroid),5(upper_aerodigestive_tract),2(endometrium)	TP53	341	0	283	108	0.276214833759591	TRUE	TRUE
ENSG00000065325.13	.	BCM	GRCh38.p13	chr17	9857439	9857439	+	C	C	T	Missense_Mutation	SNP	ENST00000262441.10	exon6	c.C628T	p.R210C	exonic	ENSG00000065325.13	.	nonsynonymous SNV	ENSG00000065325.13:ENST00000262441.10:exon6:c.C628T:p.R210C	17p13.1	C3N-02768	4.122e-05	0	0.0002	0	0	4.499e-05	0	0	rs575133662	15.20	D	D	D	D	N	D	H	T	D	0.960	T	T	D	0.475	0.928	0.928	1.141	T	D	D	D	D	D	4.410	31	0.988	D	D	0.962	12.780	0.868	12.452	0.014	0.487	0.574	0.574	0.564	.	5.280	5.280	5.460	1.026	0.599	1.000	1.000	0.983	940	GPCR,_family_2-like	.	.	ID=COSV52324255;OCCURENCE=1(ovary),1(stomach),1(thyroid),1(endometrium)	GLP2R	118	0	121	51	0.296511627906977	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11769213	11769213	+	C	C	T	Missense_Mutation	SNP	ENST00000262442.9	exon38	c.C7436T	p.T2479M	exonic	ENSG00000007174.18	.	nonsynonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon38:c.C7436T:p.T2479M	17p12	C3N-02768	1.65e-05	0.0002	0	0	0	0	0	0	rs546685970	4.19	D	.	P	P	N	N	L	T	D	0.356	T	T	D	0.112	.	0.598	0.332	T	T	T	T	T	D	2.267	21.400	0.998	N	N	-0.318	1.570	-0.447	1.291	0.000	0.487	0.574	0.574	0.564	.	5.710	1.050	0.518	1.026	0.599	0.000	0.092	0.456	837	AAA+_ATPase_domain	.	.	ID=COSV52334403;OCCURENCE=1(large_intestine)	DNAH9	620	0	618	191	0.236093943139679	TRUE	TRUE
ENSG00000176927.15	.	BCM	GRCh38.p13	chr17	30053272	30053272	+	G	G	A	Missense_Mutation	SNP	ENST00000394835.7	exon10	c.G1318A	p.E440K	exonic	ENSG00000176927.15	.	nonsynonymous SNV	ENSG00000176927.15:ENST00000394835.7:exon10:c.G1318A:p.E440K	17q11.2	C3N-02768	.	.	.	.	.	.	.	.	.	7.20	D	T	P	B	N	D	M	T	N	0.280	T	T	T	0.122	0.385	0.713	0.405	T	T	T	T	D	D	4.240	29.000	0.999	D	D	0.574	5.664	0.607	6.310	0.932	0.487	0.590	0.574	0.530	.	5.830	5.830	2.799	1.106	0.596	1.000	0.999	0.974	814	.	.	.	.	EFCAB5	51	0	90	16	0.150943396226415	TRUE	TRUE
ENSG00000176927.15	.	BCM	GRCh38.p13	chr17	30053329	30053329	+	G	G	A	Missense_Mutation	SNP	ENST00000394835.7	exon10	c.G1375A	p.E459K	exonic	ENSG00000176927.15	.	nonsynonymous SNV	ENSG00000176927.15:ENST00000394835.7:exon10:c.G1375A:p.E459K	17q11.2	C3N-02768	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	L	T	N	0.233	T	T	D	0.164	0.444	0.669	0.491	T	T	T	T	D	D	3.300	24.100	0.999	D	D	0.567	5.604	0.527	5.416	0.932	0.549	0.590	0.618	0.616	.	5.830	5.830	2.425	1.106	0.596	1.000	0.989	0.275	813	.	.	.	.	EFCAB5	107	0	172	27	0.135678391959799	TRUE	TRUE
ENSG00000176927.15	.	BCM	GRCh38.p13	chr17	30053473	30053473	+	G	G	C	Missense_Mutation	SNP	ENST00000394835.7	exon10	c.G1519C	p.E507Q	exonic	ENSG00000176927.15	.	nonsynonymous SNV	ENSG00000176927.15:ENST00000394835.7:exon10:c.G1519C:p.E507Q	17q11.2	C3N-02768	.	.	.	.	.	.	.	.	.	4.20	T	D	D	P	N	N	M	T	N	0.141	T	D	T	0.189	0.145	0.651	0.106	T	T	T	T	T	T	0.766	9.063	0.967	N	N	-0.220	1.822	-0.365	1.436	0.063	0.554	0.563	0.618	0.530	.	5.970	5.010	1.543	-0.087	-0.203	0.995	0.013	0.013	813	.	.	.	.	EFCAB5	190	1	306	41	0.118155619596542	TRUE	TRUE
ENSG00000176927.15	.	BCM	GRCh38.p13	chr17	30053497	30053497	+	G	G	A	Missense_Mutation	SNP	ENST00000394835.7	exon10	c.G1543A	p.E515K	exonic	ENSG00000176927.15	.	nonsynonymous SNV	ENSG00000176927.15:ENST00000394835.7:exon10:c.G1543A:p.E515K	17q11.2	C3N-02768	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.088	T	T	T	0.030	0.328	0.267	0.111	T	T	T	T	T	T	1.319	14.520	0.988	N	N	-0.932	0.481	-0.947	0.557	0.000	0.487	0.563	0.574	0.530	.	5.150	0.827	0.470	0.176	0.596	0.000	0.072	0.337	813	.	.	.	.	EFCAB5	244	1	374	64	0.146118721461187	TRUE	TRUE
ENSG00000176927.15	.	BCM	GRCh38.p13	chr17	30053683	30053683	+	G	G	A	Missense_Mutation	SNP	ENST00000394835.7	exon10	c.G1729A	p.G577R	exonic	ENSG00000176927.15	.	nonsynonymous SNV	ENSG00000176927.15:ENST00000394835.7:exon10:c.G1729A:p.G577R	17q11.2	C3N-02768	.	.	.	.	.	.	.	.	.	6.20	D	D	D	P	N	N	M	T	N	0.095	T	T	T	0.121	0.245	0.694	0.122	T	T	T	T	D	T	1.742	17.320	0.999	D	N	-0.099	2.179	-0.165	1.872	0.000	0.549	0.457	0.574	0.616	.	5.750	1.260	0.473	1.106	0.596	0.260	0.657	0.183	812	.	.	.	.	EFCAB5	278	0	470	79	0.143897996357013	TRUE	TRUE
ENSG00000167680.16	.	BCM	GRCh38.p13	chr19	4544521	4544521	+	G	G	A	Missense_Mutation	SNP	ENST00000586582.6	exon17	c.C1747T	p.R583W	exonic	ENSG00000167680.16	.	nonsynonymous SNV	ENSG00000167680.16:ENST00000586582.6:exon17:c.C1747T:p.R583W	19p13.3	C3N-02768	.	.	.	.	.	.	.	.	.	8.18	.	D	D	P	U	D	L	T	.	0.382	T	T	D	0.136	0.521	0.117	0.665	D	T	T	T	D	T	3.319	24.200	0.998	D	D	0.099	2.883	0.043	2.511	0.999	0.635	0.547	0.644	0.563	.	3.220	2.160	4.964	0.868	0.497	0.998	0.833	0.213	952	.	.	.	.	SEMA6B	76	0	69	27	0.28125	TRUE	TRUE
ENSG00000130382.9	.	BCM	GRCh38.p13	chr19	6213365	6213365	+	G	G	A	Missense_Mutation	SNP	ENST00000252674.9	exon11	c.C1523T	p.A508V	exonic	ENSG00000130382.9	.	nonsynonymous SNV	ENSG00000130382.9:ENST00000252674.9:exon11:c.C1523T:p.A508V	19p13.3	C3N-02768	.	.	.	.	.	.	.	.	.	8.19	D	T	B	B	U	D	M	.	N	0.743	T	T	D	0.333	0.618	0.396	1.982	D	T	T	T	D	D	3.446	24.500	0.996	D	N	-0.116	2.126	-0.092	2.069	0.926	0.707	0.702	0.723	0.714	.	4.320	3.280	7.647	1.160	0.597	1.000	0.997	0.997	952	.	.	.	.	MLLT1	278	0	402	36	0.0821917808219178	TRUE	NA
ENSG00000104883.8	.	BCM	GRCh38.p13	chr19	7482091	7482091	+	G	G	A	Missense_Mutation	SNP	ENST00000221480.6	exon3	c.C370T	p.R124W	exonic	ENSG00000104883.8	.	nonsynonymous SNV	ENSG00000104883.8:ENST00000221480.6:exon3:c.C370T:p.R124W	19p13.2	C3N-02768	4.53e-05	0	0	0	0	5.507e-05	0.0021	0	rs774587572	2.20	T	T	B	B	N	N	M	T	D	0.245	T	T	T	0.028	0.672	0.588	0.056	T	T	T	T	T	T	1.494	15.700	0.993	N	N	-0.705	0.804	-0.742	0.839	0.877	0.646	0.551	0.645	0.605	.	4.760	-1.000	0.104	0.245	0.676	0.001	0.910	0.759	889	.	.	.	.	PEX11G	177	0	266	35	0.116279069767442	TRUE	NA
ENSG00000177380.14	.	BCM	GRCh38.p13	chr19	49138260	49138260	+	C	C	T	Missense_Mutation	SNP	ENST00000334186.9	exon16	c.C1909T	p.R637W	exonic	ENSG00000177380.14	.	nonsynonymous SNV	ENSG00000177380.14:ENST00000334186.9:exon16:c.C1909T:p.R637W	19q13.33	C3N-02768	8.476e-06	0	0	0	0	1.536e-05	0	0	rs773800064	13.20	D	D	D	D	U	D	M	T	D	0.760	T	T	D	0.276	0.257	0.479	1.236	T	D	T	T	D	D	3.631	25.200	0.999	D	D	0.683	6.890	0.605	6.293	1.000	0.706	0.588	0.710	0.568	.	4.600	4.600	2.806	0.098	-0.236	1.000	0.998	0.959	631	.	.	.	ID=COSV61952960;OCCURENCE=1(stomach),1(skin)	PPFIA3	169	0	194	115	0.372168284789644	TRUE	TRUE
ENSG00000126583.11	.	BCM	GRCh38.p13	chr19	53892568	53892568	+	G	G	A	Missense_Mutation	SNP	ENST00000263431.4	exon7	c.G746A	p.R249Q	exonic	ENSG00000126583.11	.	nonsynonymous SNV	ENSG00000126583.11:ENST00000263431.4:exon7:c.G746A:p.R249Q	19q13.42	C3N-02768	.	.	.	.	.	.	.	.	.	10.19	D	T	D	P	.	D	L	T	D	0.571	T	T	D	0.543	0.815	0.687	1.112	T	D	T	T	D	D	3.745	25.600	1.000	D	D	0.378	4.209	0.364	4.111	1.000	0.706	0.547	0.710	0.568	.	4.110	4.110	4.452	1.176	0.676	1.000	0.986	0.991	994	C2_domain	.	.	.	PRKCG	247	0	414	46	0.1	TRUE	NA
ENSG00000167646.14	.	BCM	GRCh38.p13	chr19	55161370	55161370	+	C	C	T	Missense_Mutation	SNP	ENST00000524407.7	exon7	c.G712A	p.V238I	exonic	ENSG00000167646.14	.	nonsynonymous SNV	ENSG00000167646.14:ENST00000524407.7:exon7:c.G712A:p.V238I	19q13.42	C3N-02768	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	D	N	L	T	N	0.251	T	T	T	0.069	0.682	0.154	0.295	T	T	T	T	D	T	2.120	20.300	0.994	N	N	-0.057	2.313	-0.039	2.231	1.000	0.598	0.610	0.607	0.639	.	4.150	3.110	1.439	0.992	0.582	0.606	0.993	0.998	988	Dynein_assembly_factor_3,_C-terminal_domain	.	.	ID=COSV100788022;OCCURENCE=1(pancreas)	DNAAF3	143	0	305	29	0.0868263473053892	TRUE	NA
ENSG00000087510.7	.	BCM	GRCh38.p13	chr20	56633545	56633545	+	C	C	T	Missense_Mutation	SNP	ENST00000201031.3	exon4	c.C779T	p.S260L	exonic	ENSG00000087510.7	.	nonsynonymous SNV	ENSG00000087510.7:ENST00000201031.3:exon4:c.C779T:p.S260L	20q13.31	C3N-02768	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.856	D	D	D	0.944	0.864	0.985	1.932	D	D	D	D	D	D	4.309	29.700	0.999	D	D	0.996	13.811	0.937	15.440	1.000	0.677	0.563	0.673	0.530	.	5.930	5.930	7.769	1.026	0.599	1.000	0.927	0.978	976	Transcription_factor_AP-2,_C-terminal	.	.	.	TFAP2C	181	0	286	44	0.133333333333333	TRUE	TRUE
ENSG00000026036.22	.	BCM	GRCh38.p13	chr20	63688534	63688534	+	G	G	A	Missense_Mutation	SNP	ENST00000492259.6	exon19	c.G1813A	p.D605N	exonic	ENSG00000026036.22;ENSG00000258366.9	.	nonsynonymous SNV	ENSG00000026036.22:ENST00000492259.6:exon19:c.G1813A:p.D605N,ENSG00000258366.9:ENST00000370018.7:exon21:c.G1729A:p.D577N	20q13.33	C3N-02768	1.995e-05	0	0	0.0001	0	1.795e-05	0	0	rs371161995	6.20	D	T	B	B	N	N	N	D	N	0.383	T	D	D	0.299	.	0.792	.	T	T	T	T	T	D	2.454	22.300	0.990	D	N	-0.281	1.661	-0.231	1.713	1.000	0.635	0.644	0.723	0.563	.	4.770	4.770	4.946	1.079	0.618	1.000	0.035	0.062	.	ATP-dependent_helicase,_C-terminal	.	.	ID=COSV58899923;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	RTEL1-TNFRSF6B	332	0	456	55	0.107632093933464	TRUE	TRUE
ENSG00000171189.17	.	BCM	GRCh38.p13	chr21	29561768	29561768	+	C	C	A	Nonsense_Mutation	SNP	ENST00000399907.5	exon15	c.G2212T	p.E738X	exonic	ENSG00000171189.17	.	stopgain	ENSG00000171189.17:ENST00000399907.5:exon15:c.G2212T:p.E738X	21q21.3	C3N-02768	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.958	.	.	.	.	.	.	.	.	.	D	D	.	.	7.869	40	0.998	D	N	1.072	16.389	0.881	12.976	1.000	0.487	0.574	0.574	0.564	.	4.960	4.960	7.870	1.026	0.599	1.000	0.875	0.772	937	Ionotropic_glutamate_receptor	.	.	.	GRIK1	325	0	369	54	0.127659574468085	TRUE	TRUE
ENSG00000042781.14	.	BCM	GRCh38.p13	chr1	215845823	215845823	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000042781.14	ENST00000307340.8:exon45:c.9055+1G>T	.	.	1q41	C3N-02768	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.125	33	0.994	D	.	1.143	19.650	1.010	19.496	1.000	0.061	0.063	0.063	0.057	0.985	5.910	5.910	4.357	1.026	0.599	1.000	0.981	0.996	848	.	.	.	.	USH2A	484	0	579	68	0.105100463678516	TRUE	TRUE
ENSG00000123983.14	.	BCM	GRCh38.p13	chr2	222918156	222918156	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000123983.14	ENST00000357430.8:exon6:c.666+1G>A	.	.	2q36.1	C3N-02768	.	.	.	.	.	.	.	.	rs191324442	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.657	34	0.995	D	.	1.253	29.778	1.116	28.999	1.000	0.322	0.319	0.084	0.243	0.988	5.740	5.740	9.444	1.176	0.676	1.000	0.954	0.968	932	.	.	.	.	ACSL3	63	0	51	23	0.310810810810811	TRUE	NA
ENSG00000144677.15	.	BCM	GRCh38.p13	chr3	37957144	37957144	+	G	G	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000144677.15	ENST00000273179.10:exon3:c.267+1G>A	.	.	3p22.2	C3N-02768	.	.	.	.	.	.	.	.	rs200957541	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.791	33	0.993	D	.	1.018	14.499	0.838	11.359	1.000	0.109	0.071	0.060	0.125	0.886	4.960	4.050	6.839	1.176	0.676	1.000	1.000	1.000	636	.	.	.	.	CTDSPL	203	2	264	39	0.128712871287129	TRUE	NA
ENSG00000114204.14	.	BCM	GRCh38.p13	chr3	167452976	167452976	+	G	G	A	Silent	SNP	ENST00000476257.5	exon7	c.C924T	p.T308T	exonic	ENSG00000114204.14	.	synonymous SNV	ENSG00000114204.14:ENST00000476257.5:exon7:c.C924T:p.T308T	3q26.1	C3N-02768	0.0002	0.0009	0	0	0	0.0001	0	0	rs140665807	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52988479;OCCURENCE=1(kidney)	SERPINI2	119	0	151	28	0.156424581005587	TRUE	TRUE
ENSG00000229924.3	.	BCM	GRCh38.p13	chr4	9173855	9173855	+	C	C	T	Silent	SNP	ENST00000512047.2	exon5	c.C189T	p.C63C	exonic	ENSG00000229924.3	.	synonymous SNV	ENSG00000229924.3:ENST00000512047.2:exon5:c.C189T:p.C63C	4p16.1	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM90A26	361	0	359	115	0.242616033755274	NA	TRUE
ENSG00000184108.8	.	BCM	GRCh38.p13	chr4	188147114	188147114	+	C	C	T	Silent	SNP	ENST00000332517.4	exon6	c.C1149T	p.I383I	exonic	ENSG00000184108.8	.	synonymous SNV	ENSG00000184108.8:ENST00000332517.4:exon6:c.C1149T:p.I383I	4q35.2	C3N-02768	4.945e-05	0	0	0	0	6.001e-05	0	0.0001	rs758081985	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60193621;OCCURENCE=1(prostate),1(endometrium)	TRIML1	144	0	169	20	0.105820105820106	TRUE	TRUE
ENSG00000081842.18	.	BCM	GRCh38.p13	chr5	140829903	140829903	+	C	C	T	Silent	SNP	ENST00000529310.6	exon1	c.C1812T	p.N604N	exonic	ENSG00000081842.18	.	synonymous SNV	ENSG00000081842.18:ENST00000529310.6:exon1:c.C1812T:p.N604N	5q31.3	C3N-02768	8.254e-06	0	0	0	0	1.502e-05	0	0	rs782134190	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHA6	770	0	707	213	0.231521739130435	TRUE	NA
ENSG00000204560.10	.	BCM	GRCh38.p13	chr6	30662953	30662953	+	G	G	A	Silent	SNP	ENST00000376442.8	exon8	c.C1386T	p.A462A	exonic	ENSG00000204560.10	.	synonymous SNV	ENSG00000204560.10:ENST00000376442.8:exon8:c.C1386T:p.A462A	6p21.33	C3N-02768	5.172e-05	0.0002	0	0.0005	0	0	0	0	rs141437592	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DHX16	387	0	434	48	0.0995850622406639	TRUE	NA
ENSG00000028839.10	.	BCM	GRCh38.p13	chr6	133984456	133984456	+	A	A	G	Silent	SNP	ENST00000237264.9	exon5	c.A363G	p.T121T	exonic	ENSG00000028839.10	.	synonymous SNV	ENSG00000028839.10:ENST00000237264.9:exon5:c.A363G:p.T121T	6q23.2	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBPL1	145	0	173	28	0.139303482587065	TRUE	TRUE
ENSG00000105877.18	.	BCM	GRCh38.p13	chr7	21591292	21591292	+	G	G	A	Silent	SNP	ENST00000409508.8	exon14	c.G2382A	p.E794E	exonic	ENSG00000105877.18	.	synonymous SNV	ENSG00000105877.18:ENST00000409508.8:exon14:c.G2382A:p.E794E	7p15.3	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60984471;OCCURENCE=1(skin)	DNAH11	75	0	128	23	0.152317880794702	TRUE	TRUE
ENSG00000254656.2	.	BCM	GRCh38.p13	chr14	100884477	100884477	+	G	G	A	Silent	SNP	ENST00000649591.1	exon4	c.C312T	p.N104N	exonic	ENSG00000254656.2	.	synonymous SNV	ENSG00000254656.2:ENST00000649591.1:exon4:c.C312T:p.N104N	14q32.2	C3N-02768	4.978e-05	9.692e-05	0	0	0	7.559e-05	0	0	rs370765201	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66016441;OCCURENCE=1(skin)	RTL1	199	0	286	59	0.171014492753623	TRUE	TRUE
ENSG00000067141.17	.	BCM	GRCh38.p13	chr15	73260305	73260305	+	C	C	T	Silent	SNP	ENST00000261908.11	exon15	c.C2238T	p.H746H	exonic	ENSG00000067141.17	.	synonymous SNV	ENSG00000067141.17:ENST00000261908.11:exon15:c.C2238T:p.H746H	15q24.1	C3N-02768	3.299e-05	0	0	0	0	0	0	0.0002	rs148124514	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEO1	140	0	156	44	0.22	TRUE	NA
ENSG00000172349.17	.	BCM	GRCh38.p13	chr15	81299396	81299396	+	G	G	A	Silent	SNP	ENST00000302987.8	exon13	c.G2070A	p.P690P	exonic	ENSG00000172349.17	.	synonymous SNV	ENSG00000172349.17:ENST00000302987.8:exon13:c.G2070A:p.P690P	15q25.1	C3N-02768	8.263e-06	0	0	0	0	1.503e-05	0	0	rs775632260	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IL16	196	0	247	29	0.105072463768116	TRUE	NA
ENSG00000149435.12	.	BCM	GRCh38.p13	chr20	23986089	23986089	+	A	A	G	Silent	SNP	ENST00000335694.4	exon3	c.T291C	p.N97N	exonic	ENSG00000149435.12	.	synonymous SNV	ENSG00000149435.12:ENST00000335694.4:exon3:c.T291C:p.N97N	20p11.21	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GGTLC1	295	0	404	54	0.117903930131004	NA	TRUE
ENSG00000124126.14	.	BCM	GRCh38.p13	chr20	48646012	48646012	+	G	G	A	Silent	SNP	ENST00000371941.4	exon26	c.C3351T	p.D1117D	exonic	ENSG00000124126.14	.	synonymous SNV	ENSG00000124126.14:ENST00000371941.4:exon26:c.C3351T:p.D1117D	20q13.13	C3N-02768	0.0002	9.651e-05	0	0	0	0	0	0.0015	rs560827696	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PREX1	425	0	535	150	0.218978102189781	TRUE	NA
ENSG00000075043.18	.	BCM	GRCh38.p13	chr20	63406935	63406935	+	G	G	A	Silent	SNP	ENST00000359125.6	exon17	c.C2328T	p.P776P	exonic	ENSG00000075043.18	.	synonymous SNV	ENSG00000075043.18:ENST00000359125.6:exon17:c.C2328T:p.P776P	20q13.33	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCNQ2	228	0	260	67	0.204892966360856	TRUE	TRUE
ENSG00000183421.12	.	BCM	GRCh38.p13	chr21	41740883	41740883	+	G	G	A	Silent	SNP	ENST00000352483.3	exon9	c.C2454T	p.G818G	exonic	ENSG00000183421.12	.	synonymous SNV	ENSG00000183421.12:ENST00000352483.3:exon9:c.C2454T:p.G818G	21q22.3	C3N-02768	0.0001	0	0.0005	0	0	4.757e-05	0	0.0002	rs767725466	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100205401;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	RIPK4	161	0	162	31	0.160621761658031	TRUE	NA
ENSG00000224960.5	.	BCM	GRCh38.p13	chrX	27462502	27462502	+	C	C	T	Silent	SNP	ENST00000412172.4	exon1	c.G795A	p.Q265Q	exonic	ENSG00000224960.5	.	synonymous SNV	ENSG00000224960.5:ENST00000412172.4:exon1:c.G795A:p.Q265Q	Xp21.3	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPP4R3C	170	0	173	12	0.0648648648648649	TRUE	TRUE
ENSG00000116580.18	.	BCM	GRCh38.p13	chr1	155764919	155764919	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000116580.18	.	.	.	1q22	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GON4L	257	2	316	87	0.215880893300248	NA	TRUE
ENSG00000134640.2	.	BCM	GRCh38.p13	chr11	92984808	92984808	+	T	T	C	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000134640.2;ENSG00000242807.1	dist=2026;dist=67587	.	.	11q14.3	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MTNR1B	90	0	117	20	0.145985401459854	TRUE	TRUE
ENSG00000103066.13	.	BCM	GRCh38.p13	chr16	68253500	68253500	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000103066.13	.	.	.	16q22.1	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLA2G15	94	0	155	12	0.0718562874251497	TRUE	NA
ENSG00000188755.10	.	BCM	GRCh38.p13	chr17	62273815	62273815	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000188755.10	.	.	.	17q23.2	C3N-02768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBC1D3P2	734	2	1106	130	0.105177993527508	TRUE	NA
ENSG00000116213.16	.	BCM	GRCh38.p13	chr1	3635264	3635264	+	G	G	A	Missense_Mutation	SNP	ENST00000270708.12	exon7	c.C634T	p.R212W	exonic	ENSG00000116213.16	.	nonsynonymous SNV	ENSG00000116213.16:ENST00000270708.12:exon7:c.C634T:p.R212W	1p36.32	C3L-03123	1.659e-05	0	0	0	0	3.019e-05	0	0	rs762956397	16.20	D	D	D	D	D	D	M	T	D	0.886	D	T	D	0.422	.	0.679	0.729	T	T	D	D	D	D	4.060	27.400	0.999	D	D	0.822	9.229	0.705	7.849	1.000	0.706	0.725	0.710	0.714	.	5.650	5.650	6.036	1.120	0.676	1.000	0.035	0.020	945	Anaphase-promoting_complex_subunit_4,_WD40_domain	.	.	.	WRAP73	332	0	368	39	0.0958230958230958	TRUE	NA
ENSG00000158292.7	.	BCM	GRCh38.p13	chr1	6254698	6254698	+	G	G	A	Missense_Mutation	SNP	ENST00000377893.3	exon2	c.C208T	p.R70W	exonic	ENSG00000158292.7	.	nonsynonymous SNV	ENSG00000158292.7:ENST00000377893.3:exon2:c.C208T:p.R70W	1p36.31	C3L-03123	1.657e-05	0	0	0	0	3.014e-05	0	0	rs762655763	14.20	D	D	D	D	D	D	L	T	D	0.902	T	T	D	0.569	0.748	0.727	1.050	T	T	D	D	D	D	4.513	32	0.999	D	D	0.703	7.166	0.729	8.332	1.000	0.635	0.634	0.644	0.655	.	5.420	5.420	7.920	1.083	0.676	1.000	0.993	0.899	862	GPCR,_rhodopsin-like,_7TM	.	.	.	GPR153	153	1	214	18	0.0775862068965517	TRUE	NA
ENSG00000215788.10	.	BCM	GRCh38.p13	chr1	6461558	6461558	+	T	T	G	Missense_Mutation	SNP	ENST00000356876.7	exon10	c.A1130C	p.E377A	exonic	ENSG00000215788.10	.	nonsynonymous SNV	ENSG00000215788.10:ENST00000356876.7:exon10:c.A1130C:p.E377A	1p36.31	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	U	D	L	D	D	0.588	D	D	D	0.664	0.556	0.973	2.433	D	D	D	D	D	D	4.476	32	0.995	D	D	0.553	5.475	0.570	5.867	1.000	0.672	0.547	0.723	0.711	.	5.250	5.250	6.204	1.138	0.665	1.000	1.000	0.998	834	Death_domain	.	.	.	TNFRSF25	409	0	484	54	0.100371747211896	TRUE	TRUE
ENSG00000130940.15	.	BCM	GRCh38.p13	chr1	10655693	10655693	+	C	C	T	Missense_Mutation	SNP	ENST00000377022.8	exon9	c.G1621A	p.G541S	exonic	ENSG00000130940.15	.	nonsynonymous SNV	ENSG00000130940.15:ENST00000377022.8:exon9:c.G1621A:p.G541S	1p36.22	C3L-03123	.	.	.	.	.	.	.	.	rs376189072	15.19	D	D	D	D	D	D	L	.	D	0.787	T	T	D	0.294	.	0.415	.	T	D	D	D	D	D	3.441	24.500	0.999	D	D	0.576	5.690	0.562	5.778	1.000	0.696	0.634	0.723	0.605	.	4.320	4.320	5.641	1.026	0.599	1.000	0.977	0.993	792	.	.	.	.	CASZ1	282	0	345	38	0.0992167101827676	TRUE	NA
ENSG00000204624.8	.	BCM	GRCh38.p13	chr1	11516084	11516084	+	G	G	A	Missense_Mutation	SNP	ENST00000294484.7	exon6	c.G1672A	p.V558I	exonic	ENSG00000204624.8	.	nonsynonymous SNV	ENSG00000204624.8:ENST00000294484.7:exon6:c.G1672A:p.V558I	1p36.22	C3L-03123	4.976e-05	0	0	0	0	7.503e-05	0	6.061e-05	rs374554491	2.19	T	T	B	B	N	N	.	D	N	0.075	T	T	D	0.225	.	0.276	0.301	T	T	T	T	T	T	1.324	14.560	0.368	N	N	-0.693	0.824	-0.470	1.252	0.975	0.646	0.588	0.645	0.568	.	5.260	4.140	1.888	0.288	-0.116	0.994	0.958	0.985	837	Sterol-sensing_domain	.	.	ID=COSV53819941;OCCURENCE=2(large_intestine),1(biliary_tract),1(stomach),2(lung)	DISP3	270	0	348	43	0.10997442455243	TRUE	TRUE
ENSG00000116688.17	.	BCM	GRCh38.p13	chr1	12005821	12005821	+	G	G	A	Missense_Mutation	SNP	ENST00000235329.10	exon15	c.G1606A	p.D536N	exonic	ENSG00000116688.17	.	nonsynonymous SNV	ENSG00000116688.17:ENST00000235329.10:exon15:c.G1606A:p.D536N	1p36.22	C3L-03123	.	.	.	.	.	.	.	.	.	12.20	T	T	D	P	D	D	M	T	D	0.855	T	T	D	0.529	0.813	0.771	0.777	D	D	T	T	D	D	4.358	30	0.999	D	D	0.769	8.202	0.763	9.123	1.000	0.731	0.750	0.725	0.714	.	4.970	4.970	9.602	1.176	0.676	1.000	0.999	0.989	774	.	.	.	.	MFN2	774	0	830	83	0.0909090909090909	TRUE	TRUE
ENSG00000116809.11	.	BCM	GRCh38.p13	chr1	15948357	15948357	+	C	C	T	Missense_Mutation	SNP	ENST00000375743.8	exon3	c.G139A	p.E47K	exonic	ENSG00000116809.11	.	nonsynonymous SNV	ENSG00000116809.11:ENST00000375743.8:exon3:c.G139A:p.E47K	1p36.13	C3L-03123	8.256e-06	0	0	0	0	0	0	6.056e-05	rs753476579	5.20	D	T	P	B	D	D	N	T	N	0.532	T	T	T	0.123	0.678	0.180	1.195	T	T	T	T	D	T	2.655	22.700	0.999	D	N	0.300	3.778	0.393	4.310	1.000	0.742	0.602	0.775	0.711	.	5.300	5.300	2.055	1.026	0.599	0.983	1.000	0.998	410	BTB/POZ_domain	.	.	.	ZBTB17	709	0	698	87	0.110828025477707	TRUE	NA
ENSG00000117115.13	.	BCM	GRCh38.p13	chr1	17075812	17075812	+	C	C	T	Missense_Mutation	SNP	ENST00000375486.9	exon12	c.G1322A	p.R441Q	exonic	ENSG00000117115.13	.	nonsynonymous SNV	ENSG00000117115.13:ENST00000375486.9:exon12:c.G1322A:p.R441Q	1p36.13	C3L-03123	0.0001	0.0003	0	0	0.0011	4.496e-05	0.0011	6.056e-05	rs201295732	10.20	D	T	D	D	D	D	M	T	D	0.585	T	T	T	0.261	0.867	0.600	0.809	T	T	T	T	T	D	3.649	25.200	0.999	D	D	0.443	4.619	0.362	4.098	1.000	0.653	0.611	0.597	0.584	.	4.110	4.110	4.507	1.026	0.599	1.000	0.325	0.422	830	Protein-arginine_deiminase,_C-terminal	.	.	.	PADI2	376	0	472	59	0.111111111111111	TRUE	NA
ENSG00000244038.10	.	BCM	GRCh38.p13	chr1	20652647	20652647	+	A	A	G	Missense_Mutation	SNP	ENST00000415136.6	exon10	c.T1195C	p.Y399H	exonic	ENSG00000244038.10	.	nonsynonymous SNV	ENSG00000244038.10:ENST00000415136.6:exon10:c.T1195C:p.Y399H	1p36.12	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	P	D	D	M	T	D	0.917	D	D	D	0.881	0.852	0.933	0.825	D	D	D	D	D	D	4.339	29.900	0.999	D	D	0.824	9.267	0.805	10.276	1.000	0.707	0.698	0.725	0.714	.	5.650	5.650	9.290	1.312	0.756	1.000	0.996	0.995	751	.	.	.	.	DDOST	388	0	451	68	0.13102119460501	TRUE	TRUE
ENSG00000142798.20	.	BCM	GRCh38.p13	chr1	21828396	21828396	+	T	T	C	Missense_Mutation	SNP	ENST00000374695.8	exon89	c.A12268G	p.T4090A	exonic	ENSG00000142798.20	.	nonsynonymous SNV	ENSG00000142798.20:ENST00000374695.8:exon89:c.A12268G:p.T4090A	1p36.12	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	T	D	P	P	N	D	N	T	N	0.255	T	T	D	0.248	0.366	0.600	0.549	T	T	T	T	D	T	3.516	24.800	0.996	D	D	0.076	2.794	0.166	3.020	0.069	0.707	0.634	0.725	0.711	.	4.410	4.410	4.573	1.138	0.665	1.000	1.000	0.989	861	Laminin_G_domain	.	.	.	HSPG2	352	0	450	52	0.103585657370518	TRUE	TRUE
ENSG00000126698.11	.	BCM	GRCh38.p13	chr1	28203776	28203776	+	G	G	A	Missense_Mutation	SNP	ENST00000263697.6	exon8	c.C610T	p.R204W	exonic	ENSG00000126698.11	.	nonsynonymous SNV	ENSG00000126698.11:ENST00000263697.6:exon8:c.C610T:p.R204W	1p35.3	C3L-03123	2.485e-05	0	0	0	0	2.997e-05	0	6.057e-05	rs770285519	12.19	T	T	D	P	D	D	M	T	D	0.543	T	T	D	0.343	0.214	0.753	1.510	D	T	D	D	D	.	3.486	24.700	0.999	D	D	0.583	5.758	0.561	5.764	0.030	0.707	0.725	0.725	0.714	.	4.890	3.840	3.870	-0.127	-0.112	1.000	0.996	0.995	546	.	.	.	.	DNAJC8	413	1	454	39	0.0791075050709939	TRUE	NA
ENSG00000121904.17	.	BCM	GRCh38.p13	chr1	33724555	33724555	+	G	G	A	Missense_Mutation	SNP	ENST00000373388.6	exon18	c.C2725T	p.P909S	exonic	ENSG00000121904.17	.	nonsynonymous SNV	ENSG00000121904.17:ENST00000373388.6:exon18:c.C2725T:p.P909S	1p35.1	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	T	T	P	P	D	D	N	T	N	0.793	T	T	T	0.296	0.347	0.567	.	T	T	D	D	D	D	2.973	23.400	0.998	D	D	0.164	3.146	0.354	4.045	1.000	0.696	0.616	0.692	0.564	.	5.740	5.740	6.771	1.176	0.676	1.000	0.998	0.984	513	Sushi/SCR/CCP_domain	.	.	.	CSMD2	203	0	242	42	0.147887323943662	TRUE	TRUE
ENSG00000134698.11	.	BCM	GRCh38.p13	chr1	35816915	35816915	+	G	G	A	Missense_Mutation	SNP	ENST00000373210.4	exon2	c.G53A	p.R18H	exonic	ENSG00000134698.11	.	nonsynonymous SNV	ENSG00000134698.11:ENST00000373210.4:exon2:c.G53A:p.R18H	1p34.3	C3L-03123	1.648e-05	0	8.637e-05	0	0	0	0	6.057e-05	rs759153717	16.20	D	D	D	D	D	D	H	T	D	0.831	T	T	D	0.564	0.509	0.701	2.072	D	D	T	D	D	D	4.281	29.400	1.000	D	D	1.061	15.985	0.983	17.834	1.000	0.615	0.634	0.537	0.655	.	5.350	5.350	9.941	1.176	0.676	1.000	1.000	0.999	160	.	.	.	ID=COSV64617690;OCCURENCE=1(liver),1(endometrium)	AGO4	204	1	242	44	0.153846153846154	TRUE	TRUE
ENSG00000171812.13	.	BCM	GRCh38.p13	chr1	36099400	36099400	+	G	G	-	Frame_Shift_Del	DEL	ENST00000397799.2	exon4	c.281delC	p.P94Lfs*143	exonic	ENSG00000171812.13	.	frameshift deletion	ENSG00000171812.13:ENST00000397799.2:exon4:c.281delC:p.P94Lfs*143	1p34.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL8A2	204	0	254	18	0.0661764705882353	NA	TRUE
ENSG00000142694.6	.	BCM	GRCh38.p13	chr1	36322318	36322318	+	G	G	T	Missense_Mutation	SNP	ENST00000270824.1	exon3	c.C475A	p.L159M	exonic	ENSG00000142694.6	.	nonsynonymous SNV	ENSG00000142694.6:ENST00000270824.1:exon3:c.C475A:p.L159M	1p34.3	C3L-03123	.	.	.	.	.	.	.	.	.	2.19	D	D	B	B	N	N	L	.	N	0.267	T	T	T	0.054	0.139	0.123	1.414	T	T	T	T	T	T	2.115	20.200	0.992	N	N	-0.225	1.807	-0.149	1.913	1.000	0.726	0.644	0.594	0.639	.	5.010	0.733	1.511	1.101	0.590	0.985	0.549	0.275	145	.	.	.	.	EVA1B	227	0	292	34	0.104294478527607	TRUE	TRUE
ENSG00000117408.11	.	BCM	GRCh38.p13	chr1	43956922	43956922	+	A	A	G	Missense_Mutation	SNP	ENST00000372343.8	exon5	c.A1217G	p.D406G	exonic	ENSG00000117408.11	.	nonsynonymous SNV	ENSG00000117408.11:ENST00000372343.8:exon5:c.A1217G:p.D406G	1p34.1	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	P	B	D	D	L	T	D	0.754	T	T	D	0.471	0.606	0.862	1.555	D	D	D	D	D	D	3.791	25.800	0.998	D	D	0.413	4.427	0.545	5.594	1.000	0.706	0.710	0.725	0.714	.	6.030	6.030	9.049	1.290	0.731	1.000	1.000	1.000	310	.	.	.	.	IPO13	369	0	425	49	0.10337552742616	TRUE	TRUE
ENSG00000116205.14	.	BCM	GRCh38.p13	chr1	54096367	54096367	+	C	C	T	Missense_Mutation	SNP	ENST00000234827.6	exon5	c.C521T	p.T174M	exonic	ENSG00000116205.14	.	nonsynonymous SNV	ENSG00000116205.14:ENST00000234827.6:exon5:c.C521T:p.T174M	1p32.3	C3L-03123	8.252e-06	0	0	0	0	0	0.0011	0	rs764470272	7.20	D	T	D	B	D	D	L	T	N	0.299	T	T	T	0.167	0.638	0.257	0.311	T	T	T	T	D	D	2.283	21.500	0.989	D	N	0.311	3.839	0.391	4.298	1.000	0.653	0.654	0.659	0.669	.	5.340	5.340	2.443	0.126	0.599	0.977	1.000	1.000	826	Transcription_elongation_factor_S-II,_central_domain	.	.	.	TCEANC2	217	0	235	30	0.113207547169811	TRUE	NA
ENSG00000132849.20	.	BCM	GRCh38.p13	chr1	62084524	62084524	+	A	A	G	Missense_Mutation	SNP	ENST00000371158.6	exon33	c.A4253G	p.Q1418R	exonic	ENSG00000132849.20	.	nonsynonymous SNV	ENSG00000132849.20:ENST00000371158.6:exon33:c.A4253G:p.Q1418R	1p31.3	C3L-03123	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	N	M	T	N	0.212	T	T	T	0.074	0.527	0.487	0.155	T	T	T	T	D	T	2.525	22.500	0.996	D	D	-0.165	1.976	-0.025	2.276	0.990	0.706	0.588	0.710	0.568	.	5.020	3.800	3.200	1.312	0.756	0.996	0.970	0.896	951	.	.	.	.	PATJ	158	0	202	18	0.0818181818181818	TRUE	TRUE
ENSG00000187140.6	.	BCM	GRCh38.p13	chr1	63323312	63323312	+	C	C	T	Missense_Mutation	SNP	ENST00000371116.4	exon1	c.C254T	p.A85V	exonic	ENSG00000187140.6	.	nonsynonymous SNV	ENSG00000187140.6:ENST00000371116.4:exon1:c.C254T:p.A85V	1p31.3	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	T	T	D	B	N	N	N	D	N	0.037	T	T	D	0.220	0.224	0.659	.	D	T	T	T	D	T	1.473	15.560	0.997	N	N	-0.537	1.104	-0.568	1.095	1.000	0.726	0.596	0.594	0.555	.	2.860	1.950	0.161	0.853	0.366	0.256	0.931	0.733	526	.	.	.	.	FOXD3	110	0	122	12	0.0895522388059701	TRUE	TRUE
ENSG00000122482.21	.	BCM	GRCh38.p13	chr1	90937506	90937506	+	T	T	-	Frame_Shift_Del	DEL	ENST00000337393.10	exon4	c.3667delA	p.M1223Wfs*3	exonic	ENSG00000122482.21	.	frameshift deletion	ENSG00000122482.21:ENST00000337393.10:exon4:c.3667delA:p.M1223Wfs*3	1p22.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF644	339	1	344	38	0.0994764397905759	TRUE	TRUE
ENSG00000189195.14	.	BCM	GRCh38.p13	chr1	92177525	92177525	+	A	A	G	Missense_Mutation	SNP	ENST00000637221.2	exon3	c.A793G	p.S265G	exonic	ENSG00000189195.14	.	nonsynonymous SNV	ENSG00000189195.14:ENST00000637221.2:exon3:c.A793G:p.S265G	1p22.1	C3L-03123	.	.	.	.	.	.	.	.	.	0.13	.	.	.	.	N	N	.	.	.	.	T	T	T	0.041	0.151	0.014	.	T	T	T	T	T	T	0.480	6.294	0.869	N	N	-1.099	0.307	-1.135	0.341	0.000	0.554	0.588	0.547	0.621	.	5.470	-1.980	0.676	0.190	-0.050	0.007	0.277	0.739	734	.	.	.	.	BTBD8	70	0	73	4	0.051948051948052	TRUE	NA
ENSG00000198691.13	.	BCM	GRCh38.p13	chr1	94025039	94025039	+	G	G	A	Missense_Mutation	SNP	ENST00000370225.4	exon31	c.C4549T	p.R1517C	exonic	ENSG00000198691.13	.	nonsynonymous SNV	ENSG00000198691.13:ENST00000370225.4:exon31:c.C4549T:p.R1517C	1p22.1	C3L-03123	.	.	.	.	.	.	.	.	rs1800550	8.20	T	T	P	B	N	D	L	D	N	0.626	T	D	D	0.415	0.399	0.913	0.282	T	D	T	T	D	D	2.661	22.800	0.999	D	N	0.167	3.162	0.181	3.092	1.000	0.554	0.590	0.547	0.568	.	5.090	4.160	0.932	1.176	0.676	0.628	0.992	0.709	531	.	.	.	ID=COSV64676804;OCCURENCE=1(central_nervous_system),1(haematopoietic_and_lymphoid_tissue),1(small_intestine)	ABCA4	534	0	586	63	0.0970724191063174	TRUE	TRUE
ENSG00000159164.10	.	BCM	GRCh38.p13	chr1	149908114	149908114	+	C	C	T	Missense_Mutation	SNP	ENST00000369146.8	exon9	c.G1472A	p.R491H	exonic	ENSG00000159164.10	.	nonsynonymous SNV	ENSG00000159164.10:ENST00000369146.8:exon9:c.G1472A:p.R491H	1q21.2	C3L-03123	0.0001	0	0	0	0	0.0003	0	0	rs199799449	1.20	T	T	B	B	N	N	L	T	N	0.243	T	T	T	0.071	.	0.268	0.527	T	T	T	T	T	D	1.530	15.930	0.957	N	N	-0.505	1.167	-0.378	1.413	1.000	0.706	0.710	0.725	0.595	.	5.260	4.350	-0.001	1.026	0.599	0.000	0.974	0.955	188	Major_facilitator_superfamily_domain	.	.	.	SV2A	237	0	277	32	0.103559870550162	TRUE	NA
ENSG00000213171.3	.	BCM	GRCh38.p13	chr1	151802596	151802596	+	A	A	G	Missense_Mutation	SNP	ENST00000368820.4	exon2	c.T109C	p.C37R	exonic	ENSG00000213171.3	.	nonsynonymous SNV	ENSG00000213171.3:ENST00000368820.4:exon2:c.T109C:p.C37R	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.907	D	D	D	0.852	0.893	0.951	0.657	T	D	D	D	D	T	4.014	27.100	0.996	D	D	0.832	9.439	0.762	9.098	1.000	0.447	0.563	0.547	0.530	.	5.510	5.510	9.320	1.312	0.756	1.000	0.997	0.973	534	Leucine-rich_repeat_N-terminal_domain	.	.	.	LINGO4	127	0	143	8	0.0529801324503311	TRUE	NA
ENSG00000225556.1	.	BCM	GRCh38.p13	chr1	151838328	151838328	+	A	A	G	Missense_Mutation	SNP	ENST00000454109.1	exon2	c.T662C	p.L221P	exonic	ENSG00000225556.1	.	nonsynonymous SNV	ENSG00000225556.1:ENST00000454109.1:exon2:c.T662C:p.L221P	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	.	D	M	T	D	0.796	T	T	D	0.426	0.394	0.446	.	D	T	D	D	D	T	4.315	29.700	0.998	D	D	0.516	5.164	0.381	4.226	1.000	0.564	0.552	0.608	0.555	.	3.230	3.230	7.745	1.086	0.552	1.000	0.995	0.973	580	.	.	.	.	C2CD4D	245	0	206	25	0.108225108225108	TRUE	TRUE
ENSG00000197915.7	.	BCM	GRCh38.p13	chr1	152219618	152219618	+	G	G	A	Missense_Mutation	SNP	ENST00000368801.4	exon3	c.C2011T	p.H671Y	exonic	ENSG00000197915.7	.	nonsynonymous SNV	ENSG00000197915.7:ENST00000368801.4:exon3:c.C2011T:p.H671Y	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	2.19	D	D	B	B	.	N	L	T	N	0.170	T	T	T	0.044	0.361	0.331	.	T	T	T	T	T	T	0.751	8.918	0.582	N	N	-1.350	0.139	-1.440	0.132	0.000	0.487	0.547	0.574	0.564	.	3.220	-1.620	-0.211	-0.566	-0.339	0.000	0.000	0.000	570	.	.	.	.	HRNR	1076	0	1150	101	0.0807354116706635	NA	TRUE
ENSG00000197915.7	.	BCM	GRCh38.p13	chr1	152219663	152219663	+	A	A	T	Missense_Mutation	SNP	ENST00000368801.4	exon3	c.T1966A	p.S656T	exonic	ENSG00000197915.7	.	nonsynonymous SNV	ENSG00000197915.7:ENST00000368801.4:exon3:c.T1966A:p.S656T	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	1.19	T	T	P	B	.	N	M	T	N	0.103	T	T	T	0.031	0.267	0.433	.	T	T	T	T	T	T	0.834	9.732	0.556	N	N	-0.683	0.842	-0.805	0.751	0.000	0.487	0.547	0.574	0.564	.	4.050	1.380	0.593	0.968	0.554	0.000	0.001	0.001	570	.	.	.	.	HRNR	1554	0	1682	105	0.0587576944599888	NA	TRUE
ENSG00000143578.16	.	BCM	GRCh38.p13	chr1	153969153	153969153	+	T	T	C	Missense_Mutation	SNP	ENST00000368607.8	exon3	c.T398C	p.V133A	exonic	ENSG00000143578.16	.	nonsynonymous SNV	ENSG00000143578.16:ENST00000368607.8:exon3:c.T398C:p.V133A	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	D	M	T	N	0.117	T	T	T	0.055	0.284	0.391	0.039	T	T	T	T	T	T	1.760	17.450	0.788	D	N	-0.301	1.612	-0.243	1.686	1.000	0.660	0.663	0.686	0.568	.	4.800	4.800	0.720	1.055	0.665	0.682	0.201	0.219	75	.	.	.	.	CREB3L4	404	0	432	65	0.130784708249497	TRUE	TRUE
ENSG00000143549.21	.	BCM	GRCh38.p13	chr1	154191992	154191992	+	C	C	T	Missense_Mutation	SNP	ENST00000651641.1	exon1	c.G27A	p.M9I	exonic	ENSG00000143549.21	.	nonsynonymous SNV	ENSG00000143549.21:ENST00000651641.1:exon1:c.G27A:p.M9I	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	17.18	D	T	.	.	D	D	M	D	D	0.757	D	D	D	0.850	.	0.970	2.373	D	D	D	D	D	D	3.944	26.600	0.997	D	D	0.943	12.220	0.907	14.041	1.000	0.495	0.627	0.537	0.751	.	5.750	5.750	7.905	1.026	0.599	1.000	1.000	0.998	76	.	.	.	.	TPM3	775	0	822	86	0.0947136563876652	TRUE	TRUE
ENSG00000163462.18	.	BCM	GRCh38.p13	chr1	155175476	155175476	+	G	G	A	Missense_Mutation	SNP	ENST00000334634.9	exon2	c.G154A	p.V52M	exonic	ENSG00000163462.18	.	nonsynonymous SNV	ENSG00000163462.18:ENST00000334634.9:exon2:c.G154A:p.V52M	1q22	C3L-03123	.	.	.	.	.	.	.	.	rs907670977	15.20	D	D	D	D	D	D	L	D	N	0.681	D	D	D	0.668	0.684	0.480	1.803	T	T	D	D	D	D	3.731	25.500	0.999	D	N	0.660	6.600	0.595	6.159	1.000	0.726	0.588	0.594	0.555	.	4.530	4.530	2.603	1.176	0.676	0.998	1.000	0.998	70	Zinc_finger,_RING-type;RING-type_zinc-finger,_LisH_dimerisation_motif;Zinc_finger,_RING-type,_conserved_site	.	.	.	TRIM46	322	1	438	40	0.0836820083682008	TRUE	NA
ENSG00000160752.14	.	BCM	GRCh38.p13	chr1	155312363	155312363	+	C	C	T	Missense_Mutation	SNP	ENST00000356657.10	exon4	c.C448T	p.R150W	exonic	ENSG00000160752.14	.	nonsynonymous SNV	ENSG00000160752.14:ENST00000356657.10:exon4:c.C448T:p.R150W	1q22	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	N	T	D	0.531	T	T	T	0.326	0.689	0.800	0.333	T	D	T	T	T	T	2.577	22.600	0.997	D	D	-0.294	1.629	-0.201	1.782	1.000	0.722	0.686	0.702	0.735	.	4.790	1.570	0.700	1.005	0.596	0.944	0.998	0.977	40	.	.	.	ID=COSV100756081;OCCURENCE=1(cervix)	FDPS	316	0	359	46	0.11358024691358	TRUE	NA
ENSG00000254726.3	.	BCM	GRCh38.p13	chr1	156077124	156077124	+	C	C	T	Missense_Mutation	SNP	ENST00000532414.3	exon2	c.G1013A	p.S338N	exonic	ENSG00000254726.3	.	nonsynonymous SNV	ENSG00000254726.3:ENST00000532414.3:exon2:c.G1013A:p.S338N	1q22	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	T	T	P	P	D	D	L	T	N	0.345	T	T	T	0.148	0.441	0.093	1.272	D	T	T	T	D	T	3.524	24.800	0.993	D	D	0.415	4.437	0.470	4.896	1.000	0.731	0.552	0.750	0.662	.	5.190	5.190	5.593	1.022	0.545	1.000	1.000	0.996	337	.	.	.	.	MEX3A	483	0	555	73	0.116242038216561	TRUE	TRUE
ENSG00000196189.13	.	BCM	GRCh38.p13	chr1	156172928	156172928	+	G	G	A	Missense_Mutation	SNP	ENST00000368285.8	exon11	c.G1237A	p.V413M	exonic	ENSG00000196189.13	.	nonsynonymous SNV	ENSG00000196189.13:ENST00000368285.8:exon11:c.G1237A:p.V413M	1q22	C3L-03123	1.647e-05	9.612e-05	0	0	0.0002	0	0	0	rs764520336	10.20	D	D	D	D	N	D	M	T	N	0.601	T	T	T	0.231	0.613	0.443	0.674	T	T	T	T	D	D	3.946	26.600	0.999	D	D	0.764	8.123	0.691	7.588	1.000	0.778	0.702	0.854	0.639	.	5.230	5.230	5.515	1.083	0.676	1.000	0.984	0.492	481	Sema_domain	.	.	ID=COSV61771873;OCCURENCE=1(endometrium)	SEMA4A	592	0	663	87	0.116	TRUE	TRUE
ENSG00000158859.10	.	BCM	GRCh38.p13	chr1	161196846	161196846	+	A	A	G	Missense_Mutation	SNP	ENST00000367996.6	exon2	c.T668C	p.L223P	exonic	ENSG00000158859.10	.	nonsynonymous SNV	ENSG00000158859.10:ENST00000367996.6:exon2:c.T668C:p.L223P	1q23.3	C3L-03123	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.936	D	D	D	0.943	0.814	0.985	1.260	T	D	D	D	D	D	4.310	29.700	0.999	D	D	0.883	10.626	0.790	9.842	1.000	0.545	0.547	0.602	0.628	.	4.640	4.640	9.277	1.303	0.751	1.000	0.859	0.966	404	Peptidase_M12B,_ADAM/reprolysin	.	.	.	ADAMTS4	175	0	232	36	0.134328358208955	TRUE	TRUE
ENSG00000076258.10	.	BCM	GRCh38.p13	chr1	171332830	171332830	+	G	G	A	Missense_Mutation	SNP	ENST00000367749.4	exon7	c.G749A	p.R250H	exonic	ENSG00000076258.10	.	nonsynonymous SNV	ENSG00000076258.10:ENST00000367749.4:exon7:c.G749A:p.R250H	1q24.3	C3L-03123	8.253e-06	0	8.688e-05	0	0	0	0	0	rs770794489	0.20	T	T	P	P	N	N	L	T	N	0.121	T	T	T	0.173	0.477	0.735	0.193	T	T	T	T	T	T	1.750	17.370	0.387	N	N	-0.188	1.911	-0.347	1.470	0.000	0.554	0.588	0.618	0.564	.	5.630	3.560	1.593	1.176	0.671	0.008	0.170	0.029	804	.	.	.	.	FMO4	444	1	384	40	0.0943396226415094	TRUE	NA
ENSG00000116183.11	.	BCM	GRCh38.p13	chr1	176556758	176556758	+	G	G	A	Missense_Mutation	SNP	ENST00000367662.5	exon2	c.G436A	p.A146T	exonic	ENSG00000116183.11	.	nonsynonymous SNV	ENSG00000116183.11:ENST00000367662.5:exon2:c.G436A:p.A146T	1q25.2	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.032	T	T	T	0.052	0.503	0.163	0.165	T	T	T	T	T	T	0.804	9.434	0.424	N	N	-1.089	0.316	-0.825	0.724	0.027	0.487	0.590	0.547	0.564	.	4.630	2.200	2.056	0.308	-0.063	1.000	0.996	0.881	721	.	.	.	ID=COSV100866822;OCCURENCE=1(central_nervous_system)	PAPPA2	262	0	306	40	0.115606936416185	TRUE	NA
ENSG00000163395.17	.	BCM	GRCh38.p13	chr1	201222816	201222816	+	G	G	A	Missense_Mutation	SNP	ENST00000295591.12	exon21	c.G2908A	p.V970I	exonic	ENSG00000163395.17	.	nonsynonymous SNV	ENSG00000163395.17:ENST00000295591.12:exon21:c.G2908A:p.V970I	1q32.1	C3L-03123	0.0005	0.0050	0.0003	0	0	1.536e-05	0	6.433e-05	rs114765060	1.18	T	T	.	.	N	N	N	T	N	0.133	T	T	D	0.050	.	0.107	.	T	T	T	T	T	T	0.277	4.024	0.692	N	N	-1.458	0.095	-1.493	0.110	1.000	0.526	0.600	0.596	0.584	.	4.030	-0.173	0.487	-4.626	-1.733	0.024	0.000	0.008	917	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV55184728;OCCURENCE=1(skin)	IGFN1	87	0	112	15	0.118110236220472	TRUE	TRUE
ENSG00000143847.15	.	BCM	GRCh38.p13	chr1	203075694	203075694	+	C	C	T	Missense_Mutation	SNP	ENST00000447715.6	exon34	c.C3445T	p.R1149C	exonic	ENSG00000143847.15	.	nonsynonymous SNV	ENSG00000143847.15:ENST00000447715.6:exon34:c.C3445T:p.R1149C	1q32.1	C3L-03123	.	.	.	.	.	.	.	.	.	11.20	D	D	P	B	U	D	M	T	D	0.819	T	T	D	0.167	-	0.462	0.898	D	T	T	T	D	D	3.833	26.000	0.999	D	D	0.105	2.906	0.151	2.952	1.000	0.652	0.383	0.641	0.639	.	4.990	3.080	4.356	1.026	0.597	1.000	0.997	0.994	808	.	.	.	.	PPFIA4	51	0	73	12	0.141176470588235	TRUE	TRUE
ENSG00000133063.16	.	BCM	GRCh38.p13	chr1	203216980	203216980	+	A	A	G	Missense_Mutation	SNP	ENST00000367229.6	exon11	c.T1310C	p.F437S	exonic	ENSG00000133063.16	.	nonsynonymous SNV	ENSG00000133063.16:ENST00000367229.6:exon11:c.T1310C:p.F437S	1q32.1	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	D	D	P	P	N	N	M	T	D	0.523	T	T	D	0.252	0.855	0.502	0.592	T	T	T	T	D	T	1.758	17.430	0.995	N	N	-0.160	1.991	-0.457	1.272	1.000	0.497	0.547	0.608	0.542	.	4.950	-6.020	-0.247	-0.242	-0.103	0.617	0.883	0.791	878	Chitin_binding_domain	.	.	.	CHIT1	250	0	297	35	0.105421686746988	TRUE	TRUE
ENSG00000198049.7	.	BCM	GRCh38.p13	chr1	206116035	206116035	+	T	T	C	Missense_Mutation	SNP	ENST00000367126.5	exon1	c.A856G	p.I286V	exonic	ENSG00000198049.7	.	nonsynonymous SNV	ENSG00000198049.7:ENST00000367126.5:exon1:c.A856G:p.I286V	1q32.1	C3L-03123	.	.	.	.	.	.	.	.	.	2.7	T	T	.	.	.	.	.	T	N	0.679	.	.	.	.	.	.	.	.	T	.	.	.	D	3.267	24.000	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	8.017	1.138	0.665	1.000	0.989	0.979	934	GPCR,_rhodopsin-like,_7TM	.	.	.	AVPR1B	207	0	249	25	0.0912408759124088	TRUE	TRUE
ENSG00000170745.12	.	BCM	GRCh38.p13	chr2	17931070	17931070	+	-	NA	G	Frame_Shift_Ins	NA	ENST00000304101.9	exon3	c.63dupG	p.F24Lfs*2	exonic	ENSG00000170745.12	.	frameshift insertion	ENSG00000170745.12:ENST00000304101.9:exon3:c.63dupG:p.F24Lfs*2	2p24.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KCNS3	NA	NA	NA	NA	NA	NA	NA
ENSG00000119777.20	.	BCM	GRCh38.p13	chr2	27035214	27035214	+	A	A	G	Missense_Mutation	SNP	ENST00000238788.14	exon3	c.A431G	p.D144G	exonic	ENSG00000119777.20	.	nonsynonymous SNV	ENSG00000119777.20:ENST00000238788.14:exon3:c.A431G:p.D144G	2p23.3	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.916	D	D	D	0.759	0.339	0.817	0.560	T	T	D	D	D	D	4.413	31	0.999	D	D	0.787	8.535	0.781	9.583	1.000	0.732	0.672	0.744	0.714	.	5.670	5.670	8.495	1.308	0.756	1.000	1.000	0.999	444	.	.	.	.	TMEM214	337	0	350	86	0.197247706422018	TRUE	TRUE
ENSG00000075426.12	.	BCM	GRCh38.p13	chr2	28411954	28411954	+	A	A	T	Nonsense_Mutation	SNP	ENST00000264716.9	exon4	c.A487T	p.K163X	exonic	ENSG00000075426.12	.	stopgain	ENSG00000075426.12:ENST00000264716.9:exon4:c.A487T:p.K163X	2p23.2	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.712	.	.	.	.	.	.	.	.	.	D	D	.	.	7.777	39	0.996	D	N	0.845	9.734	0.697	7.700	1.000	0.672	0.588	0.659	0.711	.	4.310	4.310	7.431	1.207	0.756	1.000	1.000	0.999	453	Basic-leucine_zipper_domain	.	.	.	FOSL2	390	0	409	110	0.211946050096339	TRUE	TRUE
ENSG00000158125.10	.	BCM	GRCh38.p13	chr2	31350198	31350198	+	A	A	G	Missense_Mutation	SNP	ENST00000379416.4	exon25	c.T2657C	p.M886T	exonic	ENSG00000158125.10	.	nonsynonymous SNV	ENSG00000158125.10:ENST00000379416.4:exon25:c.T2657C:p.M886T	2p23.1	C3L-03123	.	.	.	.	.	.	.	.	.	9.20	T	T	B	B	D	D	L	T	N	0.773	T	T	D	0.408	0.475	0.745	0.102	T	T	D	D	D	D	2.715	22.900	0.626	D	D	-0.055	2.320	0.022	2.435	1.000	0.554	0.590	0.602	0.564	.	5.850	4.680	9.276	1.298	0.740	1.000	1.000	0.998	940	Aldehyde_oxidase/xanthine_dehydrogenase,_molybdopterin_binding	.	.	.	XDH	631	0	722	74	0.092964824120603	TRUE	TRUE
ENSG00000008869.12	.	BCM	GRCh38.p13	chr2	37060617	37060617	+	G	G	A	Nonsense_Mutation	SNP	ENST00000233099.6	exon12	c.C1813T	p.Q605X	exonic	ENSG00000008869.12	.	stopgain	ENSG00000008869.12:ENST00000233099.6:exon12:c.C1813T:p.Q605X	2p22.2	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.359	.	.	.	.	.	.	.	.	.	D	D	.	.	9.275	48	0.999	D	N	1.162	20.805	1.013	19.686	1.000	0.707	0.614	0.659	0.714	.	5.010	5.010	9.814	1.176	0.676	1.000	1.000	0.995	595	.	.	.	.	HEATR5B	189	0	219	72	0.247422680412371	TRUE	TRUE
ENSG00000214595.12	.	BCM	GRCh38.p13	chr2	54959120	54959120	+	C	C	T	Missense_Mutation	SNP	ENST00000356458.7	exon34	c.C4712T	p.T1571M	exonic	ENSG00000214595.12	.	nonsynonymous SNV	ENSG00000214595.12:ENST00000356458.7:exon34:c.C4712T:p.T1571M	2p16.1	C3L-03123	.	.	.	.	.	.	.	.	rs925445892	14.20	D	D	D	D	D	D	H	T	D	0.678	T	T	D	0.393	.	0.501	0.687	D	T	T	T	D	D	3.837	26.000	0.999	D	D	0.826	9.312	0.793	9.933	1.000	0.554	0.547	0.602	0.613	.	5.780	5.780	4.658	1.026	0.599	1.000	1.000	1.000	543	.	.	.	ID=COSV62864133;OCCURENCE=1(large_intestine)	EML6	136	0	168	25	0.129533678756477	TRUE	TRUE
ENSG00000138035.15	.	BCM	GRCh38.p13	chr2	55646279	55646279	+	T	T	C	Missense_Mutation	SNP	ENST00000447944.7	exon21	c.A1718G	p.E573G	exonic	ENSG00000138035.15	.	nonsynonymous SNV	ENSG00000138035.15:ENST00000447944.7:exon21:c.A1718G:p.E573G	2p16.1	C3L-03123	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	M	T	D	0.885	T	T	D	0.475	0.469	0.525	0.605	T	T	D	D	D	.	4.844	33	0.999	D	D	0.648	6.450	0.622	6.505	1.000	0.732	0.744	0.651	0.728	.	4.970	4.970	7.731	1.138	0.665	1.000	0.995	0.856	356	.	.	.	ID=COSV53177581;OCCURENCE=1(large_intestine)	PNPT1	265	0	267	66	0.198198198198198	TRUE	TRUE
ENSG00000143971.9	.	BCM	GRCh38.p13	chr2	67404283	67404283	+	A	A	T	Missense_Mutation	SNP	ENST00000272342.6	exon5	c.A1601T	p.N534I	exonic	ENSG00000143971.9	.	nonsynonymous SNV	ENSG00000143971.9:ENST00000272342.6:exon5:c.A1601T:p.N534I	2p14	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	P	P	N	N	M	T	D	0.158	T	T	T	0.074	0.174	0.117	0.229	T	T	T	T	D	T	1.455	15.450	0.971	N	N	-0.636	0.923	-0.795	0.765	0.990	0.732	0.744	0.609	0.636	.	5.760	-0.728	0.077	-0.128	-0.070	0.000	0.016	0.244	948	.	.	.	.	ETAA1	121	0	104	27	0.206106870229008	TRUE	TRUE
ENSG00000163235.16	.	BCM	GRCh38.p13	chr2	70456463	70456463	+	G	G	A	Missense_Mutation	SNP	ENST00000295400.11	exon4	c.C241T	p.R81C	exonic	ENSG00000163235.16	.	nonsynonymous SNV	ENSG00000163235.16:ENST00000295400.11:exon4:c.C241T:p.R81C	2p13.3	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.921	T	T	D	0.672	0.739	0.709	0.946	T	D	D	D	D	D	4.506	32	0.999	D	D	0.907	11.242	0.842	11.471	1.000	0.615	0.590	0.659	0.586	.	5.530	5.530	5.767	1.176	0.676	1.000	0.816	0.990	324	EGF-like,_conserved_site;EGF-like_domain	.	.	.	TGFA	263	0	243	64	0.208469055374593	TRUE	NA
ENSG00000196504.18	.	BCM	GRCh38.p13	chr2	152676723	152676723	+	G	G	A	Missense_Mutation	SNP	ENST00000410080.7	exon10	c.C713T	p.P238L	exonic	ENSG00000196504.18	.	nonsynonymous SNV	ENSG00000196504.18:ENST00000410080.7:exon10:c.C713T:p.P238L	2q23.3	C3L-03123	.	.	.	.	.	.	.	.	rs962275215	5.15	D	T	.	.	N	D	.	.	D	.	T	T	T	0.025	0.284	0.327	0.635	T	.	T	T	T	D	2.360	21.900	0.977	D	N	-0.109	2.146	0.080	2.654	1.000	0.707	0.725	0.702	0.714	.	5.260	5.260	2.783	1.176	0.676	0.996	0.931	0.883	343	.	.	.	.	PRPF40A	80	0	64	15	0.189873417721519	TRUE	NA
ENSG00000082438.17	.	BCM	GRCh38.p13	chr2	164694786	164694786	+	A	A	-	Frame_Shift_Del	DEL	ENST00000375458.6	exon11	c.2606delT	p.L869Cfs*12	exonic	ENSG00000082438.17	.	frameshift deletion	ENSG00000082438.17:ENST00000375458.6:exon11:c.2606delT:p.L869Cfs*12	2q24.3	C3L-03123	0.0027	0.0017	0.0011	0.0022	0.0005	0.0037	0.0026	0.0015	rs772030741	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COBLL1	298	12	264	103	0.280653950953678	TRUE	NA
ENSG00000138382.15	.	BCM	GRCh38.p13	chr2	169821175	169821175	+	T	T	C	Missense_Mutation	SNP	ENST00000260953.10	exon3	c.A323G	p.D108G	exonic	ENSG00000138382.15	.	nonsynonymous SNV	ENSG00000138382.15:ENST00000260953.10:exon3:c.A323G:p.D108G	2q31.1	C3L-03123	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.800	D	D	D	0.556	0.816	0.898	0.865	T	T	D	D	D	D	3.666	25.300	0.999	D	D	0.557	5.512	0.569	5.861	1.000	0.732	0.710	0.744	0.613	.	5.040	5.040	6.094	1.122	0.665	1.000	1.000	0.999	814	Methyltransferase_small_domain	.	.	.	METTL5	203	0	211	44	0.172549019607843	TRUE	TRUE
ENSG00000188738.15	.	BCM	GRCh38.p13	chr2	185753836	185753836	+	A	A	G	Missense_Mutation	SNP	ENST00000424728.6	exon8	c.A985G	p.T329A	exonic	ENSG00000188738.15	.	nonsynonymous SNV	ENSG00000188738.15:ENST00000424728.6:exon8:c.A985G:p.T329A	2q32.1	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.052	T	T	T	0.013	0.184	0.076	.	T	T	T	T	T	T	0.073	1.862	0.387	N	N	-1.146	0.268	-1.231	0.258	0.000	0.554	0.588	0.574	0.621	.	4.700	-4.160	-0.434	1.284	0.744	0.000	0.222	0.209	751	.	.	.	.	FSIP2	67	0	54	7	0.114754098360656	TRUE	TRUE
ENSG00000115896.16	.	BCM	GRCh38.p13	chr2	198085015	198085015	+	C	C	T	Nonsense_Mutation	SNP	ENST00000428675.6	exon2	c.C1498T	p.Q500X	exonic	ENSG00000115896.16	.	stopgain	ENSG00000115896.16:ENST00000428675.6:exon2:c.C1498T:p.Q500X	2q33.1	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.499	.	.	.	.	.	.	.	.	.	D	D	.	.	6.645	36	0.998	D	N	1.162	20.769	1.014	19.724	1.000	0.638	0.588	0.547	0.668	.	5.940	5.940	7.895	1.026	0.599	1.000	0.894	0.754	716	Phosphatidylinositol-specific_phospholipase_C,_X_domain	.	.	.	PLCL1	144	0	176	10	0.0537634408602151	TRUE	NA
ENSG00000178385.15	.	BCM	GRCh38.p13	chr2	208001134	208001134	+	T	T	A	Missense_Mutation	SNP	ENST00000427836.8	exon2	c.A506T	p.Q169L	exonic	ENSG00000178385.15	.	nonsynonymous SNV	ENSG00000178385.15:ENST00000427836.8:exon2:c.A506T:p.Q169L	2q33.3	C3L-03123	.	.	.	.	.	.	.	.	.	6.19	D	D	P	B	U	D	N	D	N	0.330	T	T	D	0.283	0.274	0.452	0.142	T	T	T	T	T	.	1.837	18.000	0.957	D	N	-0.568	1.047	-0.489	1.220	0.999	0.651	0.654	0.602	0.684	.	5.330	2.840	2.029	0.145	-0.186	1.000	0.445	0.003	799	.	.	.	.	PLEKHM3	412	0	518	41	0.073345259391771	TRUE	TRUE
ENSG00000115414.20	.	BCM	GRCh38.p13	chr2	215383328	215383328	+	C	C	A	Missense_Mutation	SNP	ENST00000354785.10	exon31	c.G5050T	p.D1684Y	exonic	ENSG00000115414.20	.	nonsynonymous SNV	ENSG00000115414.20:ENST00000354785.10:exon31:c.G5050T:p.D1684Y	2q35	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.575	D	T	D	0.397	0.458	0.800	1.011	T	D	D	T	D	D	5.985	35	0.994	D	D	0.599	5.913	0.484	5.019	1.000	0.732	0.588	0.744	0.711	.	4.020	4.020	4.538	0.798	0.599	1.000	0.994	0.936	798	Fibronectin_type_III	.	.	ID=COSV60548363;OCCURENCE=1(large_intestine)	FN1	470	1	538	35	0.0610820244328098	TRUE	TRUE
ENSG00000138375.13	.	BCM	GRCh38.p13	chr2	216428659	216428659	+	C	C	T	Missense_Mutation	SNP	ENST00000357276.9	exon7	c.C1211T	p.A404V	exonic	ENSG00000138375.13	.	nonsynonymous SNV	ENSG00000138375.13:ENST00000357276.9:exon7:c.C1211T:p.A404V	2q35	C3L-03123	8.236e-06	0	0	0	0	0	0	6.056e-05	rs761003078	8.20	T	D	P	B	D	D	M	D	N	0.115	T	D	T	0.258	0.274	0.891	0.523	T	T	T	T	D	T	1.637	16.610	0.999	D	N	0.130	3.006	0.270	3.547	1.000	0.707	0.725	0.725	0.714	.	6.070	6.070	3.314	1.026	0.599	0.996	0.077	0.135	844	.	.	.	.	SMARCAL1	428	0	604	58	0.0876132930513595	TRUE	NA
ENSG00000127831.11	.	BCM	GRCh38.p13	chr2	218424307	218424307	+	A	A	G	Missense_Mutation	SNP	ENST00000248444.10	exon3	c.A106G	p.T36A	exonic	ENSG00000127831.11	.	nonsynonymous SNV	ENSG00000127831.11:ENST00000248444.10:exon3:c.A106G:p.T36A	2q35	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.158	T	T	T	0.022	0.284	0.470	0.183	T	T	T	T	T	T	1.079	12.560	0.294	N	N	-0.939	0.472	-0.796	0.764	0.156	0.706	0.574	0.710	0.564	.	4.380	1.760	0.261	1.312	0.691	0.001	1.000	0.978	890	Gelsolin-like_domain	.	.	.	VIL1	190	0	315	40	0.112676056338028	TRUE	TRUE
ENSG00000116106.12	.	BCM	GRCh38.p13	chr2	221563821	221563821	+	T	T	-	Frame_Shift_Del	DEL	ENST00000281821.7	exon3	c.733delA	p.M245Cfs*89	exonic	ENSG00000116106.12	.	frameshift deletion	ENSG00000116106.12:ENST00000281821.7:exon3:c.733delA:p.M245Cfs*89	2q36.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EPHA4	373	0	459	41	0.082	TRUE	TRUE
ENSG00000130561.17	.	BCM	GRCh38.p13	chr2	233338678	233338678	+	T	T	C	Missense_Mutation	SNP	ENST00000409110.6	exon12	c.T947C	p.I316T	exonic	ENSG00000130561.17	.	nonsynonymous SNV	ENSG00000130561.17:ENST00000409110.6:exon12:c.T947C:p.I316T	2q37.1	C3L-03123	.	.	.	.	.	.	.	.	.	5.19	D	T	P	P	N	N	L	T	D	0.318	T	T	T	0.162	0.644	0.475	0.177	T	T	T	T	D	.	3.199	23.900	0.997	D	D	-0.001	2.507	0.028	2.459	1.000	0.560	0.624	0.547	0.530	.	5.380	5.380	4.959	1.138	0.665	0.780	0.994	0.999	878	Arrestin_C-terminal-like_domain	.	.	.	SAG	158	0	227	23	0.092	TRUE	TRUE
ENSG00000167165.19	.	BCM	GRCh38.p13	chr2	233772404	233772404	+	T	T	G	Missense_Mutation	SNP	ENST00000305139.11	exon5	c.T1444G	p.W482G	exonic	ENSG00000167165.19;ENSG00000240224.1;ENSG00000241119.2;ENSG00000241635.8;ENSG00000242366.3;ENSG00000242515.5;ENSG00000243135.6;ENSG00000244122.2;ENSG00000244474.6	.	nonsynonymous SNV	ENSG00000167165.19:ENST00000305139.11:exon5:c.T1444G:p.W482G,ENSG00000241635.8:ENST00000305208.10:exon5:c.T1447G:p.W483G,ENSG00000242515.5:ENST00000344644.9:exon5:c.T1438G:p.W480G,ENSG00000241119.2:ENST00000354728.5:exon5:c.T1438G:p.W480G,ENSG00000244474.6:ENST00000373409.8:exon5:c.T1450G:p.W484G,ENSG00000240224.1:ENST00000373414.3:exon5:c.T1450G:p.W484G,ENSG00000244122.2:ENST00000373426.3:exon5:c.T1438G:p.W480G,ENSG00000242366.3:ENST00000373450.4:exon5:c.T1438G:p.W480G,ENSG00000243135.6:ENST00000482026.5:exon5:c.T1450G:p.W484G	2q37.1	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.954	D	D	D	0.871	0.926	0.918	0.927	T	D	D	D	D	D	4.275	29.400	0.982	D	D	0.977	13.226	0.912	14.266	1.000	0.487	0.590	0.574	0.564	.	5.830	5.830	7.809	1.071	0.587	1.000	1.000	0.991	697	.	.	.	.	UGT1A6	565	0	647	73	0.101388888888889	TRUE	TRUE
ENSG00000204104.12	.	BCM	GRCh38.p13	chr2	238325902	238325902	+	G	G	A	Missense_Mutation	SNP	ENST00000373327.5	exon3	c.G286A	p.V96M	exonic	ENSG00000204104.12	.	nonsynonymous SNV	ENSG00000204104.12:ENST00000373327.5:exon3:c.G286A:p.V96M	2q37.3	C3L-03123	1.648e-05	0	0	0	0	2.999e-05	0	0	rs527454385	14.20	D	D	D	D	D	D	M	T	D	0.814	T	T	T	0.400	0.701	0.689	0.578	T	T	D	D	D	D	3.563	24.900	0.999	D	D	0.697	7.076	0.601	6.239	1.000	0.706	0.709	0.710	0.684	.	4.330	3.440	7.717	1.176	0.676	1.000	0.512	0.508	912	.	.	.	.	TRAF3IP1	232	1	261	83	0.241279069767442	TRUE	NA
ENSG00000226321.5	.	BCM	GRCh38.p13	chr2	240963611	240963611	+	G	G	A	Missense_Mutation	SNP	ENST00000443866.2	exon21	c.G3149A	p.R1050H	exonic	ENSG00000226321.5	.	nonsynonymous SNV	ENSG00000226321.5:ENST00000443866.2:exon21:c.G3149A:p.R1050H	2q37.3	C3L-03123	.	.	.	.	.	.	.	.	rs965037522	0.9	.	T	.	.	.	.	.	.	.	0.129	T	T	.	0.074	.	0.048	.	.	T	T	T	T	.	1.268	14.150	0.982	N	N	-0.650	0.899	-0.824	0.724	0.999	0.403	0.547	0.578	0.563	.	3.810	-1.240	-0.014	0.217	0.604	0.000	0.887	0.770	970	.	.	.	.	CROCC2	227	0	250	72	0.22360248447205	TRUE	NA
ENSG00000168395.16	.	BCM	GRCh38.p13	chr2	241709317	241709317	+	G	G	A	Missense_Mutation	SNP	ENST00000313552.11	exon3	c.G211A	p.A71T	exonic	ENSG00000168395.16	.	nonsynonymous SNV	ENSG00000168395.16:ENST00000313552.11:exon3:c.G211A:p.A71T	2q37.3	C3L-03123	.	.	.	.	.	.	.	.	rs747667282	10.19	T	T	P	B	D	D	M	.	N	0.740	T	T	D	0.273	0.299	0.301	1.748	T	T	D	D	D	D	2.388	22.000	0.997	D	D	0.411	4.410	0.461	4.821	1.000	0.707	0.702	0.702	0.714	.	5.740	4.860	8.933	1.094	0.604	1.000	0.975	0.695	970	Inhibitor_of_growth_protein,_N-terminal_histone-binding	.	.	.	ING5	188	0	239	48	0.167247386759582	TRUE	NA
ENSG00000144619.15	.	BCM	GRCh38.p13	chr3	3026122	3026122	+	C	C	-	Frame_Shift_Del	DEL	ENST00000418658.6	exon15	c.1507delC	p.P504Lfs*18	exonic	ENSG00000144619.15	.	frameshift deletion	ENSG00000144619.15:ENST00000418658.6:exon15:c.1507delC:p.P504Lfs*18	3p26.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNTN4	503	0	444	38	0.0788381742738589	TRUE	TRUE
ENSG00000150995.19	.	BCM	GRCh38.p13	chr3	4665217	4665217	+	G	G	A	Missense_Mutation	SNP	ENST00000649015.1	exon17	c.G1634A	p.R545Q	exonic	ENSG00000150995.19	.	nonsynonymous SNV	ENSG00000150995.19:ENST00000649015.1:exon17:c.G1634A:p.R545Q	3p26.1	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	T	P	P	D	D	M	D	D	0.576	D	D	D	0.761	0.494	0.927	1.697	T	D	D	D	D	D	4.188	28.500	0.999	D	D	0.487	4.938	0.504	5.195	1.000	0.615	0.654	0.602	0.655	.	4.560	4.560	6.831	1.176	0.676	1.000	0.929	0.819	946	RIH_domain	.	.	.	ITPR1	231	0	249	32	0.113879003558719	TRUE	TRUE
ENSG00000163702.20	.	BCM	GRCh38.p13	chr3	9928379	9928379	+	G	G	A	Missense_Mutation	SNP	ENST00000295981.7	exon11	c.G1165A	p.A389T	exonic	ENSG00000163702.20	.	nonsynonymous SNV	ENSG00000163702.20:ENST00000295981.7:exon11:c.G1165A:p.A389T	3p25.3	C3L-03123	0.0037	0.0005	0.0009	0	0.0178	0.0044	0.0023	0.0009	rs145516404	3.19	D	T	D	D	N	N	L	T	N	0.262	T	T	.	0.159	.	0.102	0.291	T	T	T	T	T	T	2.687	22.800	0.997	N	N	-0.474	1.229	-0.550	1.123	0.999	0.696	0.547	0.723	0.636	.	4.840	3.950	2.774	1.176	0.676	0.362	0.004	0.007	644	Interleukin-17_receptor_C/E,_N-terminal	.	.	.	IL17RC	103	0	120	17	0.124087591240876	TRUE	NA
ENSG00000131386.19	.	BCM	GRCh38.p13	chr3	16212687	16212687	+	G	G	A	Missense_Mutation	SNP	ENST00000339732.10	exon6	c.G1316A	p.R439H	exonic	ENSG00000131386.19	.	nonsynonymous SNV	ENSG00000131386.19:ENST00000339732.10:exon6:c.G1316A:p.R439H	3p25.1	C3L-03123	2.471e-05	0	0	0	0	2.997e-05	0	6.056e-05	rs149803620	13.20	D	D	D	P	N	D	H	T	D	0.593	D	T	D	0.460	.	0.658	0.246	T	D	T	T	D	D	3.560	24.900	0.999	D	D	0.654	6.525	0.509	5.245	0.994	0.516	0.563	0.547	0.586	.	5.380	3.530	4.426	0.049	0.590	1.000	0.917	0.935	878	.	.	.	ID=COSV60220265;OCCURENCE=1(large_intestine)	GALNT15	458	0	459	56	0.10873786407767	TRUE	TRUE
ENSG00000177479.19	.	BCM	GRCh38.p13	chr3	48967161	48967161	+	T	T	C	Missense_Mutation	SNP	ENST00000356401.8	exon6	c.T424C	p.C142R	exonic	ENSG00000177479.19	.	nonsynonymous SNV	ENSG00000177479.19:ENST00000356401.8:exon6:c.T424C:p.C142R	3p21.31	C3L-03123	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.983	D	D	D	0.915	0.873	0.996	2.250	D	D	D	D	D	D	4.202	28.700	0.997	D	D	0.554	5.482	0.615	6.417	1.000	0.722	0.699	0.725	0.714	.	5.870	5.870	7.481	1.138	0.609	1.000	1.000	0.990	0	Zinc_finger,_RING-type	.	.	.	ARIH2	155	0	196	30	0.132743362831858	TRUE	TRUE
ENSG00000172046.19	.	BCM	GRCh38.p13	chr3	49116098	49116098	+	G	G	A	Missense_Mutation	SNP	ENST00000398888.6	exon9	c.C1117T	p.R373C	exonic	ENSG00000172046.19	.	nonsynonymous SNV	ENSG00000172046.19:ENST00000398888.6:exon9:c.C1117T:p.R373C	3p21.31	C3L-03123	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	N	T	D	0.609	T	T	T	0.236	0.632	0.117	0.669	T	T	T	T	D	D	3.728	25.500	0.999	D	D	0.593	5.849	0.629	6.601	0.999	0.745	0.702	0.732	0.636	.	5.920	4.980	3.605	1.176	0.676	1.000	0.998	0.998	0	CS_domain	.	.	.	USP19	141	0	197	21	0.0963302752293578	TRUE	TRUE
ENSG00000172037.14	.	BCM	GRCh38.p13	chr3	49130290	49130290	+	C	C	T	Missense_Mutation	SNP	ENST00000305544.9	exon9	c.G1166A	p.C389Y	exonic	ENSG00000172037.14	.	nonsynonymous SNV	ENSG00000172037.14:ENST00000305544.9:exon9:c.G1166A:p.C389Y	3p21.31	C3L-03123	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.983	D	D	D	0.981	0.990	0.998	1.760	D	T	D	D	D	D	3.856	26.100	0.997	D	D	1.071	16.330	0.949	16.035	1.000	0.737	0.590	0.733	0.714	.	5.170	5.170	7.899	1.026	0.549	1.000	1.000	0.970	0	Laminin_EGF_domain	.	.	.	LAMB2	416	0	512	51	0.0905861456483126	TRUE	TRUE
ENSG00000187492.9	.	BCM	GRCh38.p13	chr3	49798852	49798852	+	G	G	T	Missense_Mutation	SNP	ENST00000412678.7	exon4	c.C469A	p.P157T	exonic	ENSG00000187492.9	.	nonsynonymous SNV	ENSG00000187492.9:ENST00000412678.7:exon4:c.C469A:p.P157T	3p21.31	C3L-03123	.	.	.	.	.	.	.	.	.	7.20	D	D	P	B	N	N	M	T	D	0.608	T	T	D	0.095	0.358	0.421	0.229	T	T	T	T	D	T	2.469	22.300	0.996	D	N	-0.376	1.436	-0.306	1.553	1.000	0.554	0.588	0.547	0.613	.	4.810	3.940	4.624	0.221	-0.202	1.000	0.896	0.489	2	.	.	.	.	CDHR4	259	0	309	31	0.0911764705882353	TRUE	TRUE
ENSG00000114349.10	.	BCM	GRCh38.p13	chr3	50194573	50194573	+	G	G	T	Missense_Mutation	SNP	ENST00000232461.8	exon7	c.G781T	p.V261L	exonic	ENSG00000114349.10	.	nonsynonymous SNV	ENSG00000114349.10:ENST00000232461.8:exon7:c.G781T:p.V261L	3p21.31	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	B	B	D	D	M	D	N	0.565	T	D	D	0.615	0.616	0.957	0.824	D	T	D	D	D	D	3.328	24.200	0.994	D	D	0.017	2.571	0.188	3.126	1.000	0.649	0.596	0.504	0.636	.	5.140	5.140	4.550	1.176	0.676	1.000	1.000	0.986	4	.	.	.	.	GNAT1	522	0	635	67	0.0954415954415954	TRUE	TRUE
ENSG00000157445.15	.	BCM	GRCh38.p13	chr3	54562808	54562808	+	A	A	T	Missense_Mutation	SNP	ENST00000474759.6	exon6	c.A553T	p.I185F	exonic	ENSG00000157445.15	.	nonsynonymous SNV	ENSG00000157445.15:ENST00000474759.6:exon6:c.A553T:p.I185F	3p14.3	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.911	T	T	D	0.628	0.872	0.767	1.192	T	D	D	D	D	D	4.035	27.200	0.988	D	D	0.914	11.421	0.858	12.080	1.000	0.487	0.574	0.547	0.564	.	5.820	5.820	9.118	1.207	0.756	1.000	0.874	0.841	887	VWA_N-terminal	.	.	.	CACNA2D3	127	0	136	24	0.15	TRUE	TRUE
ENSG00000136068.15	.	BCM	GRCh38.p13	chr3	58153476	58153476	+	T	T	C	Missense_Mutation	SNP	ENST00000295956.9	exon39	c.T6469C	p.F2157L	exonic	ENSG00000136068.15	.	nonsynonymous SNV	ENSG00000136068.15:ENST00000295956.9:exon39:c.T6469C:p.F2157L	3p14.3	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.943	D	D	D	0.699	0.751	0.749	0.962	T	D	D	D	D	D	4.428	31	0.999	D	D	0.652	6.498	0.669	7.207	1.000	0.707	0.702	0.725	0.711	.	5.770	5.770	8.017	1.138	0.665	1.000	0.967	0.971	574	.	.	.	.	FLNB	513	0	574	68	0.105919003115265	TRUE	TRUE
ENSG00000185008.17	.	BCM	GRCh38.p13	chr3	77558016	77558016	+	C	C	T	Missense_Mutation	SNP	ENST00000461745.5	exon9	c.C1304T	p.A435V	exonic	ENSG00000185008.17	.	nonsynonymous SNV	ENSG00000185008.17:ENST00000461745.5:exon9:c.C1304T:p.A435V	3p12.3	C3L-03123	1.661e-05	0.0001	0	0	0	1.502e-05	0	0	rs748723178	5.19	T	T	P	B	D	.	N	T	N	0.629	T	T	D	0.269	0.558	0.718	0.679	T	T	T	T	T	D	1.820	17.880	0.550	D	D	0.082	2.814	0.187	3.121	1.000	0.554	0.574	0.602	0.564	.	5.680	5.680	6.089	1.026	0.549	1.000	0.765	0.417	798	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV59935500;OCCURENCE=1(endometrium)	ROBO2	343	0	337	49	0.126943005181347	TRUE	TRUE
ENSG00000080200.10	.	BCM	GRCh38.p13	chr3	97872363	97872363	+	G	G	A	Missense_Mutation	SNP	ENST00000389622.7	exon4	c.G1169A	p.R390H	exonic	ENSG00000080200.10	.	nonsynonymous SNV	ENSG00000080200.10:ENST00000389622.7:exon4:c.G1169A:p.R390H	3q11.2	C3L-03123	.	.	.	.	.	.	.	.	.	1.11	.	D	.	.	.	.	.	.	.	0.058	T	T	.	0.053	0.241	0.203	.	T	T	T	T	T	T	1.703	17.050	0.941	N	N	-0.688	0.832	-0.646	0.978	1.000	0.781	0.588	0.618	0.600	.	5.960	4.080	0.896	1.176	0.676	0.001	0.023	0.063	797	.	.	.	ID=COSV51711661;OCCURENCE=1(large_intestine)	CRYBG3	198	0	239	35	0.127737226277372	TRUE	TRUE
ENSG00000175054.16	.	BCM	GRCh38.p13	chr3	142556459	142556459	+	G	G	A	Missense_Mutation	SNP	ENST00000350721.9	exon9	c.C2002T	p.R668W	exonic	ENSG00000175054.16	.	nonsynonymous SNV	ENSG00000175054.16:ENST00000350721.9:exon9:c.C2002T:p.R668W	3q23	C3L-03123	8.25e-06	0	0	0	0	0	0	6.059e-05	rs761352811	14.20	D	D	D	D	D	D	L	T	D	0.745	T	T	D	0.551	0.574	0.897	0.689	T	T	D	D	D	D	4.175	28.400	0.999	D	D	0.464	4.767	0.461	4.823	0.743	0.651	0.654	0.659	0.684	.	5.160	4.280	4.223	0.220	0.618	1.000	0.999	0.998	616	.	.	.	.	ATR	234	0	264	26	0.0896551724137931	TRUE	NA
ENSG00000213186.8	.	BCM	GRCh38.p13	chr3	160438024	160438024	+	C	C	T	Missense_Mutation	SNP	ENST00000309784.9	exon3	c.G1160A	p.C387Y	exonic	ENSG00000213186.8	.	nonsynonymous SNV	ENSG00000213186.8:ENST00000309784.9:exon3:c.G1160A:p.C387Y	3q25.33	C3L-03123	.	.	.	.	.	.	.	.	.	2.20	T	D	B	B	N	D	N	T	N	0.094	T	T	T	0.050	0.651	0.145	0.102	T	T	T	T	T	T	0.329	4.622	0.373	N	N	-0.927	0.487	-0.917	0.597	1.000	0.707	0.725	0.609	0.592	.	5.680	2.920	0.141	-0.244	-1.062	0.039	0.904	0.052	754	.	.	.	.	TRIM59	40	0	45	8	0.150943396226415	TRUE	TRUE
ENSG00000114204.14	.	BCM	GRCh38.p13	chr3	167471659	167471659	+	A	A	G	Missense_Mutation	SNP	ENST00000476257.5	exon3	c.T176C	p.V59A	exonic	ENSG00000114204.14	.	nonsynonymous SNV	ENSG00000114204.14:ENST00000476257.5:exon3:c.T176C:p.V59A	3q26.1	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	D	D	P	B	N	N	L	D	N	0.488	T	T	D	0.531	0.751	0.650	0.524	T	T	D	T	D	T	3.666	25.300	0.995	D	D	0.421	4.479	0.503	5.184	0.276	0.487	0.574	0.547	0.564	.	5.700	5.700	6.023	1.312	0.756	0.881	0.994	0.988	716	Serpin_domain	.	.	.	SERPINI2	310	0	283	35	0.110062893081761	TRUE	NA
ENSG00000114248.10	.	BCM	GRCh38.p13	chr3	169869681	169869681	+	C	C	T	Missense_Mutation	SNP	ENST00000316428.10	exon1	c.G127A	p.D43N	exonic	ENSG00000114248.10	.	nonsynonymous SNV	ENSG00000114248.10:ENST00000316428.10:exon1:c.G127A:p.D43N	3q26.2	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	T	T	P	B	N	N	M	T	N	0.104	T	T	T	0.035	0.222	0.213	0.029	T	T	T	T	T	T	0.688	8.343	0.585	N	N	-0.685	0.837	-0.741	0.841	0.617	0.447	0.492	0.547	0.530	.	4.400	3.530	0.488	0.877	0.599	0.000	0.014	0.011	422	.	.	.	.	LRRC31	195	0	243	33	0.119565217391304	TRUE	NA
ENSG00000114770.17	.	BCM	GRCh38.p13	chr3	183988677	183988677	+	G	G	A	Missense_Mutation	SNP	ENST00000334444.11	exon4	c.C338T	p.S113L	exonic	ENSG00000114770.17	.	nonsynonymous SNV	ENSG00000114770.17:ENST00000334444.11:exon4:c.C338T:p.S113L	3q27.1	C3L-03123	8.252e-06	0	0	0	0	1.502e-05	0	0	rs758646463	11.20	D	D	D	P	D	D	M	T	D	0.812	T	T	T	0.351	0.583	0.440	0.839	T	T	T	T	D	D	3.461	24.600	0.999	D	D	0.741	7.740	0.721	8.164	1.000	0.737	0.588	0.733	0.636	.	5.750	5.750	7.193	1.176	0.676	1.000	0.992	0.991	351	.	.	.	ID=COSV55586863;OCCURENCE=4(skin),1(lung)	ABCC5	273	0	285	32	0.100946372239748	TRUE	TRUE
ENSG00000145191.15	.	BCM	GRCh38.p13	chr3	184140153	184140153	+	A	A	C	Missense_Mutation	SNP	ENST00000648915.2	exon6	c.A839C	p.E280A	exonic	ENSG00000145191.15	.	nonsynonymous SNV	ENSG00000145191.15:ENST00000648915.2:exon6:c.A839C:p.E280A	3q27.1	C3L-03123	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.814	D	D	D	0.901	0.783	0.924	0.708	D	T	D	D	D	D	4.192	28.600	0.997	D	D	0.888	10.756	0.864	12.290	1.000	0.732	0.723	0.744	0.714	.	5.930	5.930	8.880	1.312	0.756	1.000	0.999	0.988	851	.	.	.	.	EIF2B5	549	0	661	84	0.112751677852349	TRUE	TRUE
ENSG00000136527.18	.	BCM	GRCh38.p13	chr3	185922117	185922117	+	G	G	A	Missense_Mutation	SNP	ENST00000453386.7	exon5	c.C532T	p.R178C	exonic	ENSG00000136527.18	.	nonsynonymous SNV	ENSG00000136527.18:ENST00000453386.7:exon5:c.C532T:p.R178C	3q27.2	C3L-03123	.	.	.	.	.	.	.	.	.	9.20	T	D	B	B	D	D	L	T	D	0.461	T	T	T	0.148	0.413	0.223	2.076	D	T	T	T	D	D	3.326	24.200	0.997	D	D	0.067	2.756	0.221	3.287	1.000	0.672	0.698	0.702	0.711	.	6.030	4.190	4.594	1.176	0.676	1.000	1.000	0.998	923	RNA_recognition_motif_domain	.	.	.	TRA2B	100	0	132	15	0.102040816326531	TRUE	NA
ENSG00000061938.19	.	BCM	GRCh38.p13	chr3	195882259	195882259	+	C	C	T	Missense_Mutation	SNP	ENST00000333602.13	exon6	c.G679A	p.G227R	exonic	ENSG00000061938.19	.	nonsynonymous SNV	ENSG00000061938.19:ENST00000333602.13:exon6:c.G679A:p.G227R	3q29	C3L-03123	.	.	.	.	.	.	.	.	.	7.20	T	T	D	P	N	D	N	D	N	0.670	T	T	T	0.262	0.495	0.933	1.053	T	T	T	T	D	D	3.038	23.500	0.999	D	D	0.096	2.870	0.221	3.288	0.550	0.672	0.702	0.723	0.636	.	4.740	4.740	1.531	1.022	0.596	1.000	1.000	0.999	884	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	TNK2	367	0	397	66	0.142548596112311	TRUE	TRUE
ENSG00000072274.13	.	BCM	GRCh38.p13	chr3	196074002	196074002	+	C	C	T	Missense_Mutation	SNP	ENST00000360110.9	exon4	c.G362A	p.R121H	exonic	ENSG00000072274.13	.	nonsynonymous SNV	ENSG00000072274.13:ENST00000360110.9:exon4:c.G362A:p.R121H	3q29	C3L-03123	8.238e-05	0	0.0008	0	0	1.499e-05	0	0	rs772641140	0.20	T	T	B	B	N	N	L	T	N	0.054	T	T	T	0.024	0.437	0.309	0.199	T	T	T	T	T	T	-0.113	0.779	0.719	N	N	-1.152	0.263	-1.185	0.296	1.000	0.707	0.672	0.702	0.714	.	5.500	-0.264	-1.065	-0.815	-1.338	0.000	0.022	0.000	613	.	.	.	ID=COSV64053836;OCCURENCE=1(lung),1(endometrium)	TFRC	239	0	252	34	0.118881118881119	TRUE	TRUE
ENSG00000159788.19	.	BCM	GRCh38.p13	chr4	3317380	3317380	+	G	G	A	Missense_Mutation	SNP	ENST00000344733.9	exon2	c.G1210A	p.A404T	exonic	ENSG00000159788.19	.	nonsynonymous SNV	ENSG00000159788.19:ENST00000344733.9:exon2:c.G1210A:p.A404T	4p16.3	C3L-03123	8.25e-06	0	0	0	0	1.502e-05	0	0	rs768337709	11.20	D	D	D	P	D	D	M	T	N	0.756	T	T	D	0.201	0.323	0.618	0.610	T	T	T	T	D	D	3.224	23.900	0.999	D	D	0.631	6.253	0.636	6.698	1.000	0.615	0.588	0.659	0.636	.	4.730	4.730	9.613	1.164	0.604	1.000	0.814	0.755	693	.	.	.	ID=COSV60907521;OCCURENCE=3(large_intestine),1(haematopoietic_and_lymphoid_tissue)	RGS12	315	0	428	49	0.10272536687631	TRUE	TRUE
ENSG00000157765.13	.	BCM	GRCh38.p13	chr4	25676469	25676469	+	G	G	A	Missense_Mutation	SNP	ENST00000382051.8	exon13	c.G1793A	p.R598H	exonic	ENSG00000157765.13	.	nonsynonymous SNV	ENSG00000157765.13:ENST00000382051.8:exon13:c.G1793A:p.R598H	4p15.2	C3L-03123	8.253e-06	0	0	0	0	0	0	6.057e-05	rs780836430	0.20	T	T	B	B	N	N	N	T	N	0.113	T	T	T	0.169	0.761	0.263	0.301	T	T	T	T	T	T	-0.739	0.035	0.865	N	N	-1.643	0.046	-1.580	0.081	0.082	0.615	0.547	0.659	0.564	.	5.180	-7.820	0.053	-1.293	-1.153	0.410	0.920	0.778	923	.	.	.	.	SLC34A2	408	2	455	55	0.107843137254902	TRUE	NA
ENSG00000145244.12	.	BCM	GRCh38.p13	chr4	47692994	47692994	+	C	C	T	Missense_Mutation	SNP	ENST00000273857.9	exon6	c.G889A	p.D297N	exonic	ENSG00000145244.12	.	nonsynonymous SNV	ENSG00000145244.12:ENST00000273857.9:exon6:c.G889A:p.D297N	4p12	C3L-03123	8.242e-06	0	0	0	0	1.499e-05	0	0	rs751480678	19.20	D	D	D	D	D	D	M	D	D	0.912	D	D	D	0.780	0.720	0.967	0.319	T	D	D	D	D	D	4.115	27.900	0.999	D	D	0.726	7.491	0.660	7.068	1.000	0.581	0.627	0.565	0.613	.	5.650	4.790	7.324	1.023	0.544	1.000	0.701	0.961	535	.	.	.	ID=COSV56687485;OCCURENCE=2(liver)	CORIN	252	0	251	44	0.149152542372881	TRUE	TRUE
ENSG00000138663.9	.	BCM	GRCh38.p13	chr4	83063125	83063125	+	C	C	A	Nonsense_Mutation	SNP	ENST00000264389.7	exon7	c.C765A	p.C255X	exonic	ENSG00000138663.9	.	stopgain	ENSG00000138663.9:ENST00000264389.7:exon7:c.C765A:p.C255X	4q21.22	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.564	.	.	.	.	.	.	.	.	.	D	D	.	.	6.671	36	0.994	D	N	0.638	6.332	0.449	4.726	0.003	0.732	0.744	0.710	0.714	.	5.830	1.520	0.527	0.126	0.549	0.997	1.000	0.999	917	Proteasome_component_(PCI)_domain	.	.	.	COPS4	199	1	222	12	0.0512820512820513	TRUE	TRUE
ENSG00000163644.15	.	BCM	GRCh38.p13	chr4	88278474	88278474	+	G	G	A	Missense_Mutation	SNP	ENST00000608933.6	exon2	c.C110T	p.T37M	exonic	ENSG00000163644.15	.	nonsynonymous SNV	ENSG00000163644.15:ENST00000608933.6:exon2:c.C110T:p.T37M	4q22.1	C3L-03123	8.243e-05	9.623e-05	0.0003	0	0.0002	5.998e-05	0	6.059e-05	rs537053098	1.20	T	T	B	B	N	N	L	T	N	0.111	T	T	T	0.037	.	0.636	0.300	T	T	T	T	T	D	0.925	10.710	0.983	N	N	-0.447	1.284	-0.476	1.241	1.000	0.624	0.517	0.668	0.568	.	4.310	3.470	0.535	1.071	0.524	0.001	0.002	0.438	673	.	.	.	ID=COSV55796456;OCCURENCE=1(large_intestine)	PPM1K	432	0	403	50	0.11037527593819	TRUE	TRUE
ENSG00000138814.17	.	BCM	GRCh38.p13	chr4	101093824	101093824	+	T	T	C	Missense_Mutation	SNP	ENST00000394854.8	exon6	c.A734G	p.Q245R	exonic	ENSG00000138814.17	.	nonsynonymous SNV	ENSG00000138814.17:ENST00000394854.8:exon6:c.A734G:p.Q245R	4q24	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	N	T	N	0.461	T	T	T	0.143	0.324	0.642	1.434	D	D	T	T	D	D	2.294	21.500	0.975	D	D	-0.161	1.989	0.042	2.507	1.000	0.706	0.670	0.710	0.613	.	5.260	5.260	4.729	1.129	0.597	1.000	1.000	0.999	861	Serine/threonine-specific_protein_phosphatase/bis(5-nucleosyl)-tetraphosphatase;Calcineurin-like_phosphoesterase_domain,_ApaH_type	.	.	ID=COSV59928585;OCCURENCE=2(large_intestine)	PPP3CA	109	1	98	9	0.0841121495327103	NA	TRUE
ENSG00000138658.15	.	BCM	GRCh38.p13	chr4	112617493	112617493	+	G	G	A	Missense_Mutation	SNP	ENST00000505019.5	exon6	c.C2549T	p.T850I	exonic	ENSG00000138658.15	.	nonsynonymous SNV	ENSG00000138658.15:ENST00000505019.5:exon6:c.C2549T:p.T850I	4q25	C3L-03123	.	.	.	.	.	.	.	.	.	3.19	D	T	B	B	N	N	L	D	N	0.129	T	T	D	0.065	0.279	0.250	0.076	.	T	T	T	T	T	0.215	3.293	0.943	N	N	-1.025	0.378	-1.046	0.434	0.000	0.615	0.634	0.609	0.655	.	5.980	2.250	0.164	-1.264	-0.780	0.000	0.001	0.100	832	.	.	.	.	ZGRF1	89	0	101	12	0.106194690265487	TRUE	NA
ENSG00000138741.11	.	BCM	GRCh38.p13	chr4	121911978	121911978	+	G	G	A	Missense_Mutation	SNP	ENST00000379645.8	exon5	c.C1457T	p.T486M	exonic	ENSG00000138741.11	.	nonsynonymous SNV	ENSG00000138741.11:ENST00000379645.8:exon5:c.C1457T:p.T486M	4q27	C3L-03123	1.649e-05	0	0	0	0	1.5e-05	0	6.058e-05	rs766044392	5.16	T	T	.	.	D	D	.	T	N	0.541	T	T	D	0.150	.	0.507	0.801	T	.	T	T	T	D	2.304	21.600	0.936	D	N	0.017	2.573	0.181	3.092	0.011	0.554	0.574	0.618	0.530	.	5.490	5.490	2.734	1.083	0.676	0.993	0.938	0.878	834	.	.	.	ID=COSV99312717;OCCURENCE=1(ovary)	TRPC3	464	0	474	60	0.112359550561798	TRUE	NA
ENSG00000137473.17	.	BCM	GRCh38.p13	chr4	146939864	146939864	+	C	C	T	Missense_Mutation	SNP	ENST00000325106.8	exon3	c.G32A	p.R11H	exonic	ENSG00000137473.17	.	nonsynonymous SNV	ENSG00000137473.17:ENST00000325106.8:exon3:c.G32A:p.R11H	4q31.22	C3L-03123	4.248e-05	0.0001	0	0	0	6.101e-05	0	0	rs759589838	1.20	T	T	B	B	N	N	L	T	D	0.144	T	T	T	0.030	.	0.113	0.016	T	T	T	T	T	T	0.788	9.275	0.998	N	N	-0.795	0.663	-0.735	0.850	0.021	0.549	0.574	0.574	0.616	.	5.300	2.430	-0.128	0.138	0.599	0.000	0.330	0.921	925	.	.	.	ID=COSV57271312;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue),1(kidney)	TTC29	243	0	307	27	0.0808383233532934	TRUE	TRUE
ENSG00000198589.14	.	BCM	GRCh38.p13	chr4	150590764	150590764	+	C	C	T	Missense_Mutation	SNP	ENST00000357115.9	exon40	c.G6175A	p.D2059N	exonic	ENSG00000198589.14	.	nonsynonymous SNV	ENSG00000198589.14:ENST00000357115.9:exon40:c.G6175A:p.D2059N	4q31.3	C3L-03123	.	.	.	.	.	.	.	.	.	11.20	T	D	D	D	N	D	M	T	D	0.768	T	T	D	0.164	0.469	0.533	0.528	T	T	T	T	D	D	3.551	24.900	0.999	D	D	0.408	4.395	0.529	5.433	1.000	0.707	0.725	0.688	0.564	.	5.850	5.850	7.568	1.026	0.599	1.000	1.000	0.998	820	.	.	.	.	LRBA	208	0	245	23	0.0858208955223881	TRUE	NA
ENSG00000154447.15	.	BCM	GRCh38.p13	chr4	169107052	169107052	+	C	C	A	Missense_Mutation	SNP	ENST00000284637.14	exon11	c.G2293T	p.G765C	exonic	ENSG00000154447.15	.	nonsynonymous SNV	ENSG00000154447.15:ENST00000284637.14:exon11:c.G2293T:p.G765C	4q32.3	C3L-03123	.	.	.	.	.	.	.	.	.	4.20	D	T	D	P	N	N	M	T	N	0.406	T	T	T	0.157	0.260	0.537	0.876	T	T	T	T	D	T	2.572	22.600	0.996	N	N	-0.036	2.387	-0.195	1.797	1.000	0.651	0.654	0.651	0.636	.	5.760	4.920	1.074	1.026	0.599	0.003	0.001	0.001	824	.	.	.	.	SH3RF1	245	0	272	35	0.11400651465798	TRUE	TRUE
ENSG00000083857.14	.	BCM	GRCh38.p13	chr4	186619820	186619820	+	C	C	T	Missense_Mutation	SNP	ENST00000441802.7	exon10	c.G6766A	p.A2256T	exonic	ENSG00000083857.14	.	nonsynonymous SNV	ENSG00000083857.14:ENST00000441802.7:exon10:c.G6766A:p.A2256T	4q35.2	C3L-03123	3.312e-05	0	0	0.0002	0	2.997e-05	0	0	rs752611276	18.20	D	D	D	D	D	D	H	T	D	0.979	D	D	D	0.803	0.818	0.746	0.496	T	D	D	D	D	D	3.437	24.500	0.998	D	D	0.799	8.766	0.599	6.207	1.000	0.672	0.574	0.702	0.668	.	5.050	5.050	7.905	1.026	0.599	1.000	0.013	0.085	889	Cadherin-like	.	.	ID=COSV71675024;OCCURENCE=2(large_intestine)	FAT1	251	0	287	35	0.108695652173913	TRUE	TRUE
ENSG00000185028.4	.	BCM	GRCh38.p13	chr5	195199	195199	+	G	G	A	Missense_Mutation	SNP	ENST00000328278.4	exon2	c.G1391A	p.R464Q	exonic	ENSG00000185028.4	.	nonsynonymous SNV	ENSG00000185028.4:ENST00000328278.4:exon2:c.G1391A:p.R464Q	5p15.33	C3L-03123	2.485e-05	0	0	0	0	4.497e-05	0	0	rs764290390	0.20	T	T	B	B	N	N	N	T	N	0.234	T	T	T	0.044	.	0.061	0.243	T	T	T	T	T	T	0.596	7.477	0.933	N	N	-1.187	0.236	-1.158	0.319	0.992	0.554	0.588	0.576	0.563	.	5.410	-1.620	1.784	0.143	-0.113	0.719	0.030	0.007	862	.	.	.	ID=COSV57255999;OCCURENCE=1(bone)	LRRC14B	556	0	730	126	0.147196261682243	TRUE	TRUE
ENSG00000174358.16	.	BCM	GRCh38.p13	chr5	1214046	1214046	+	T	T	C	Missense_Mutation	SNP	ENST00000304460.11	exon6	c.T868C	p.S290P	exonic	ENSG00000174358.16	.	nonsynonymous SNV	ENSG00000174358.16:ENST00000304460.11:exon6:c.T868C:p.S290P	5p15.33	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.937	D	D	D	0.893	0.892	0.948	0.883	T	D	D	D	D	D	4.448	32	0.999	D	D	0.816	9.103	0.713	8.000	1.000	0.403	0.547	0.578	0.613	.	4.960	4.960	4.721	1.073	0.609	1.000	1.000	0.968	952	.	.	.	.	SLC6A19	450	0	492	50	0.0922509225092251	TRUE	TRUE
ENSG00000170561.13	.	BCM	GRCh38.p13	chr5	2748378	2748378	+	G	G	A	Missense_Mutation	SNP	ENST00000302057.6	exon3	c.C1330T	p.R444W	exonic	ENSG00000170561.13	.	nonsynonymous SNV	ENSG00000170561.13:ENST00000302057.6:exon3:c.C1330T:p.R444W	5p15.33	C3L-03123	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	N	D	M	T	D	0.739	T	T	D	0.401	0.257	0.733	0.864	D	T	D	D	D	T	3.562	24.900	0.998	D	D	-0.067	2.283	-0.140	1.938	1.000	0.646	0.574	0.696	0.639	.	4.430	0.708	1.305	-0.336	-0.306	1.000	0.948	0.749	927	.	.	.	.	IRX2	453	0	402	70	0.148305084745763	TRUE	TRUE
ENSG00000170549.4	.	BCM	GRCh38.p13	chr5	3596337	3596337	+	G	G	A	Missense_Mutation	SNP	ENST00000302006.4	exon1	c.G232A	p.A78T	exonic	ENSG00000170549.4	.	nonsynonymous SNV	ENSG00000170549.4:ENST00000302006.4:exon1:c.G232A:p.A78T	5p15.33	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	T	T	D	D	U	D	M	T	N	0.467	T	T	D	0.212	0.376	0.912	.	D	T	T	T	D	D	3.913	26.400	0.999	N	N	0.382	4.234	0.284	3.623	1.000	0.685	0.547	0.674	0.639	.	2.560	2.560	2.762	1.008	0.516	1.000	0.834	0.930	987	.	.	.	.	IRX1	150	0	210	29	0.121338912133891	TRUE	TRUE
ENSG00000168685.15	.	BCM	GRCh38.p13	chr5	35867414	35867414	+	G	G	T	Missense_Mutation	SNP	ENST00000303115.8	exon3	c.G330T	p.K110N	exonic	ENSG00000168685.15	.	nonsynonymous SNV	ENSG00000168685.15:ENST00000303115.8:exon3:c.G330T:p.K110N	5p13.2	C3L-03123	.	.	.	.	.	.	.	.	.	4.20	T	D	D	P	N	N	M	T	N	0.517	T	T	D	0.296	0.491	0.868	0.090	T	T	T	T	T	T	1.229	13.860	0.994	N	N	-0.369	1.451	-0.553	1.118	0.993	0.615	0.588	0.574	0.655	.	5.700	-1.780	-0.234	-0.670	-0.198	0.054	0.154	0.066	632	.	.	.	ID=COSV57414424;OCCURENCE=1(breast),1(large_intestine)	IL7R	266	1	298	40	0.118343195266272	TRUE	TRUE
ENSG00000197603.14	.	BCM	GRCh38.p13	chr5	37184842	37184842	+	G	G	A	Missense_Mutation	SNP	ENST00000425232.6	exon25	c.C4427T	p.T1476M	exonic	ENSG00000197603.14	.	nonsynonymous SNV	ENSG00000197603.14:ENST00000425232.6:exon25:c.C4427T:p.T1476M	5p13.2	C3L-03123	.	.	.	.	.	.	.	.	.	3.16	D	T	.	.	N	N	.	T	D	0.078	T	T	D	0.224	.	0.395	0.234	.	T	T	T	T	T	0.350	4.859	0.955	N	N	-0.690	0.830	-0.743	0.838	1.000	0.707	0.686	0.602	0.714	.	6.080	3.380	0.642	-0.552	-1.694	0.003	0.040	0.030	140	.	.	.	.	CPLANE1	324	0	333	44	0.116710875331565	TRUE	NA
ENSG00000169271.3	.	BCM	GRCh38.p13	chr5	54456136	54456136	+	G	G	A	Missense_Mutation	SNP	ENST00000302005.3	exon1	c.G347A	p.R116Q	exonic	ENSG00000169271.3	.	nonsynonymous SNV	ENSG00000169271.3:ENST00000302005.3:exon1:c.G347A:p.R116Q	5q11.2	C3L-03123	0.0008	0	0.0083	0	0	1.498e-05	0	0.0004	rs150931007	18.20	D	D	D	D	D	D	H	D	D	0.915	D	D	D	0.881	.	0.959	0.511	T	D	D	D	T	D	4.281	29.400	1.000	D	D	0.977	13.216	0.896	13.583	1.000	0.447	0.563	0.547	0.530	.	5.810	5.810	7.817	1.176	0.676	0.999	0.991	0.579	503	Heat_shock_protein_beta-3;Alpha_crystallin/Hsp20_domain	.	.	ID=COSV57356641;OCCURENCE=1(pancreas)	HSPB3	834	0	917	112	0.108843537414966	TRUE	TRUE
ENSG00000164253.14	.	BCM	GRCh38.p13	chr5	77433254	77433254	+	T	T	C	Missense_Mutation	SNP	ENST00000296679.9	exon13	c.A1261G	p.T421A	exonic	ENSG00000164253.14	.	nonsynonymous SNV	ENSG00000164253.14:ENST00000296679.9:exon13:c.A1261G:p.T421A	5q13.3	C3L-03123	.	.	.	.	.	.	.	.	.	12.20	D	D	P	B	D	D	M	T	N	0.876	T	T	D	0.533	0.621	0.594	0.145	T	T	D	D	D	D	3.444	24.500	0.996	D	D	0.576	5.684	0.646	6.853	1.000	0.732	0.744	0.710	0.728	.	5.960	5.960	7.354	1.138	0.609	1.000	1.000	0.992	646	.	.	.	.	WDR41	172	0	169	23	0.119791666666667	TRUE	TRUE
ENSG00000158985.13	.	BCM	GRCh38.p13	chr5	131385630	131385630	+	A	A	G	Missense_Mutation	SNP	ENST00000505065.1	exon4	c.A142G	p.S48G	exonic	ENSG00000158985.13	.	nonsynonymous SNV	ENSG00000158985.13:ENST00000505065.1:exon4:c.A142G:p.S48G	5q31.1	C3L-03123	.	.	.	.	.	.	.	.	.	5.18	T	T	B	B	D	D	.	.	N	0.547	T	T	T	0.234	0.151	0.266	0.685	T	T	T	T	D	T	2.479	22.400	0.994	D	D	0.000	2.512	0.142	2.912	1.000	0.719	0.702	0.710	0.734	.	4.510	4.510	5.648	1.312	0.756	1.000	0.998	0.997	386	CRIB_domain	.	.	.	CDC42SE2	170	0	154	26	0.144444444444444	TRUE	TRUE
ENSG00000069018.19	.	BCM	GRCh38.p13	chr5	136216250	136216250	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000513104.6	exon11	c.2368dupA	p.R790Kfs*13	exonic	ENSG00000069018.19	.	frameshift insertion	ENSG00000069018.19:ENST00000513104.6:exon11:c.2368dupA:p.R790Kfs*13	5q31.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRPC7	NA	NA	NA	NA	NA	NA	NA
ENSG00000240764.4	.	BCM	GRCh38.p13	chr5	141489728	141489728	+	G	G	A	Missense_Mutation	SNP	ENST00000252087.3	exon1	c.G488A	p.G163D	exonic	ENSG00000240764.4	.	nonsynonymous SNV	ENSG00000240764.4:ENST00000252087.3:exon1:c.G488A:p.G163D	5q31.3	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.880	T	T	D	0.566	0.665	0.905	1.252	D	T	D	D	D	D	4.034	27.200	0.997	D	D	0.990	13.596	0.914	14.347	1.000	0.516	0.588	0.409	0.586	.	6.080	6.080	9.955	1.176	0.676	1.000	0.997	0.928	737	Cadherin-like	.	.	ID=COSV52776399;OCCURENCE=1(thyroid)	PCDHGC5	198	0	215	26	0.107883817427386	TRUE	TRUE
ENSG00000156453.13	.	BCM	GRCh38.p13	chr5	141863836	141863836	+	G	G	A	Missense_Mutation	SNP	ENST00000394536.4	exon3	c.C2495T	p.T832M	exonic	ENSG00000156453.13	.	nonsynonymous SNV	ENSG00000156453.13:ENST00000394536.4:exon3:c.C2495T:p.T832M	5q31.3	C3L-03123	6.606e-05	0	8.642e-05	0	0	0.0001	0	0	rs555945646	14.20	D	D	D	D	D	D	M	T	D	0.803	T	T	D	0.554	.	0.155	1.335	T	T	T	D	D	D	4.071	27.500	0.999	D	D	0.830	9.387	0.783	9.647	1.000	0.672	0.590	0.702	0.711	.	5.230	5.230	9.957	1.176	0.676	1.000	0.671	0.526	910	Protocadherin	.	.	.	PCDH1	352	1	406	49	0.107692307692308	TRUE	NA
ENSG00000113555.5	.	BCM	GRCh38.p13	chr5	141955067	141955067	+	G	G	A	Missense_Mutation	SNP	ENST00000231484.3	exon1	c.C2785T	p.R929C	exonic	ENSG00000113555.5	.	nonsynonymous SNV	ENSG00000113555.5:ENST00000231484.3:exon1:c.C2785T:p.R929C	5q31.3	C3L-03123	1.67e-05	0	8.648e-05	0	0	1.52e-05	0	0	rs182860036	10.20	D	D	D	P	N	D	M	T	N	0.223	T	T	D	0.192	.	0.875	0.509	T	T	T	T	D	D	4.366	31	0.999	D	D	0.564	5.572	0.540	5.542	1.000	0.615	0.547	0.547	0.655	.	4.810	4.810	6.560	1.176	0.676	1.000	0.639	0.911	870	.	.	.	ID=COSV51521112;OCCURENCE=1(large_intestine),1(skin)	PCDH12	423	0	516	58	0.101045296167247	TRUE	TRUE
ENSG00000145819.18	.	BCM	GRCh38.p13	chr5	143134073	143134073	+	C	C	T	Missense_Mutation	SNP	ENST00000274498.9	exon19	c.C1805T	p.T602M	exonic	ENSG00000145819.18	.	nonsynonymous SNV	ENSG00000145819.18:ENST00000274498.9:exon19:c.C1805T:p.T602M	5q31.3	C3L-03123	4.956e-05	0.0003	0	0.0001	0.0002	0	0	6.115e-05	rs770272847	9.20	D	T	D	D	D	D	M	T	N	0.655	T	T	T	0.185	0.285	0.424	1.254	T	T	T	T	T	D	3.166	23.800	0.999	D	D	0.649	6.456	0.692	7.613	1.000	0.707	0.725	0.644	0.542	.	5.950	5.950	5.524	1.026	0.599	1.000	0.998	0.893	910	.	.	.	ID=COSV50843457;OCCURENCE=1(NS)	ARHGAP26	102	0	118	23	0.163120567375887	TRUE	TRUE
ENSG00000113649.11	.	BCM	GRCh38.p13	chr5	146503405	146503405	+	A	A	G	Missense_Mutation	SNP	ENST00000296702.9	exon17	c.A2413G	p.N805D	exonic	ENSG00000113649.11	.	nonsynonymous SNV	ENSG00000113649.11:ENST00000296702.9:exon17:c.A2413G:p.N805D	5q32	C3L-03123	.	.	.	.	.	.	.	.	rs755292554	5.20	T	T	B	B	D	D	N	T	N	0.178	T	T	T	0.128	0.485	0.374	1.115	T	T	T	T	D	D	2.359	21.900	0.988	D	N	-0.365	1.460	-0.064	2.152	0.998	0.732	0.744	0.725	0.728	.	5.050	5.050	6.523	1.295	0.691	1.000	1.000	0.999	920	FF_domain	.	.	.	TCERG1	159	0	201	37	0.15546218487395	TRUE	NA
ENSG00000135074.16	.	BCM	GRCh38.p13	chr5	157497046	157497046	+	C	C	T	Missense_Mutation	SNP	ENST00000517905.1	exon14	c.G1442A	p.C481Y	exonic	ENSG00000135074.16	.	nonsynonymous SNV	ENSG00000135074.16:ENST00000517905.1:exon14:c.G1442A:p.C481Y	5q33.3	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	T	D	0.970	D	D	D	0.696	0.941	0.841	1.894	T	D	D	D	D	D	3.993	26.900	0.998	D	D	0.742	7.755	0.706	7.864	1.000	0.732	0.702	0.786	0.728	.	5.350	5.350	7.870	1.008	0.599	1.000	0.966	0.934	813	Disintegrin_domain	.	.	.	ADAM19	149	0	191	29	0.131818181818182	TRUE	TRUE
ENSG00000145934.16	.	BCM	GRCh38.p13	chr5	168247685	168247685	+	A	A	G	Missense_Mutation	SNP	ENST00000518659.5	exon27	c.A6746G	p.D2249G	exonic	ENSG00000145934.16	.	nonsynonymous SNV	ENSG00000145934.16:ENST00000518659.5:exon27:c.A6746G:p.D2249G	5q34	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.929	D	D	D	0.935	0.678	0.928	1.429	T	T	D	D	D	D	4.252	29.200	0.998	D	D	0.910	11.315	0.866	12.370	1.000	0.638	0.547	0.653	0.564	.	5.590	5.590	9.325	1.312	0.756	1.000	0.998	0.990	898	.	.	.	.	TENM2	332	0	343	45	0.115979381443299	TRUE	TRUE
ENSG00000131187.9	.	BCM	GRCh38.p13	chr5	177404544	177404544	+	G	G	A	Missense_Mutation	SNP	ENST00000253496.3	exon8	c.C755T	p.A252V	exonic	ENSG00000131187.9	.	nonsynonymous SNV	ENSG00000131187.9:ENST00000253496.3:exon8:c.C755T:p.A252V	5q35.3	C3L-03123	.	.	.	.	.	.	.	.	rs985081288	1.20	T	T	P	B	N	N	L	T	N	0.137	T	T	D	0.077	0.469	0.705	0.841	T	T	T	T	T	T	0.814	9.529	0.984	N	N	-0.772	0.696	-0.878	0.650	1.000	0.564	0.179	0.504	0.273	.	5.010	0.324	-0.183	0.111	0.590	0.000	0.047	0.829	929	Kringle	.	.	.	F12	340	0	472	29	0.0578842315369262	TRUE	NA
ENSG00000161013.17	.	BCM	GRCh38.p13	chr5	179799619	179799619	+	G	G	T	Missense_Mutation	SNP	ENST00000292591.12	exon9	c.C928A	p.L310M	exonic	ENSG00000161013.17	.	nonsynonymous SNV	ENSG00000161013.17:ENST00000292591.12:exon9:c.C928A:p.L310M	5q35.3	C3L-03123	.	.	.	.	.	.	.	.	.	7.19	T	T	D	D	D	D	L	T	N	0.505	T	T	T	0.100	0.283	0.285	1.300	D	T	T	T	D	.	2.709	22.800	0.993	D	N	0.296	3.759	0.260	3.493	1.000	0.672	0.702	0.702	0.711	.	4.370	3.500	2.431	0.158	0.672	0.997	0.973	0.984	906	.	.	.	.	MGAT4B	262	0	309	55	0.151098901098901	TRUE	TRUE
ENSG00000146054.18	.	BCM	GRCh38.p13	chr5	181204764	181204764	+	T	T	C	Missense_Mutation	SNP	ENST00000274773.12	exon1	c.A347G	p.H116R	exonic	ENSG00000146054.18	.	nonsynonymous SNV	ENSG00000146054.18:ENST00000274773.12:exon1:c.A347G:p.H116R	5q35.3	C3L-03123	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	T	N	0.064	T	T	D	0.029	0.195	0.208	1.571	D	T	T	T	T	T	-0.091	0.864	0.498	N	N	-1.502	0.080	-1.522	0.100	1.000	0.455	0.542	0.608	0.568	.	3.390	-3.430	-0.597	-0.450	-0.625	0.000	0.004	0.023	.	.	.	.	.	TRIM7	238	0	199	18	0.0829493087557604	TRUE	TRUE
ENSG00000095951.17	.	BCM	GRCh38.p13	chr6	12122680	12122680	+	A	A	-	Frame_Shift_Del	DEL	ENST00000379388.7	exon4	c.2885delA	p.T963Lfs*30	exonic	ENSG00000095951.17	.	frameshift deletion	ENSG00000095951.17:ENST00000379388.7:exon4:c.2885delA:p.T963Lfs*30	6p24.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HIVEP1	207	0	315	30	0.0869565217391304	TRUE	TRUE
ENSG00000204498.11	.	BCM	GRCh38.p13	chr6	31558483	31558483	+	C	C	T	Missense_Mutation	SNP	ENST00000376148.9	exon4	c.C1018T	p.R340C	exonic	ENSG00000204498.11	.	nonsynonymous SNV	ENSG00000204498.11:ENST00000376148.9:exon4:c.C1018T:p.R340C	6p21.33	C3L-03123	0	0	0	0	0	0	0	0	rs200385924	9.19	D	D	D	B	N	D	.	T	D	0.543	T	T	D	0.135	.	0.204	1.808	T	T	T	T	D	D	3.420	24.500	0.999	D	N	0.475	4.845	0.502	5.174	1.000	0.732	0.672	0.744	0.735	.	5.640	4.730	3.101	1.026	0.599	0.961	1.000	0.998	934	.	.	.	.	NFKBIL1	286	0	368	39	0.0958230958230958	TRUE	NA
ENSG00000204469.13	.	BCM	GRCh38.p13	chr6	31629258	31629258	+	G	G	A	Missense_Mutation	SNP	ENST00000376033.3	exon13	c.G1880A	p.R627H	exonic	ENSG00000204469.13	.	nonsynonymous SNV	ENSG00000204469.13:ENST00000376033.3:exon13:c.G1880A:p.R627H	6p21.33	C3L-03123	.	.	.	.	.	.	.	.	rs1011254957	6.20	D	T	D	P	D	D	L	T	N	0.245	T	T	T	0.139	0.129	0.093	0.435	T	T	T	T	D	D	3.418	24.500	0.999	N	N	0.431	4.539	0.401	4.365	1.000	0.672	0.698	0.702	0.711	.	5.550	5.550	1.251	1.163	0.664	0.002	0.046	0.967	878	.	.	.	.	PRRC2A	166	0	226	32	0.124031007751938	TRUE	NA
ENSG00000204396.11	.	BCM	GRCh38.p13	chr6	31775408	31775408	+	A	A	G	Missense_Mutation	SNP	ENST00000375688.5	exon4	c.T535C	p.W179R	exonic	ENSG00000204396.11	.	nonsynonymous SNV	ENSG00000204396.11:ENST00000375688.5:exon4:c.T535C:p.W179R	6p21.33	C3L-03123	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	M	T	D	0.950	T	T	D	0.781	.	0.516	1.350	T	T	D	D	D	.	4.159	28.300	0.997	D	D	0.784	8.476	0.767	9.207	1.000	0.554	0.588	0.578	0.568	.	5.670	5.670	7.742	1.312	0.756	1.000	1.000	0.983	895	.	.	.	.	VWA7	200	0	265	23	0.0798611111111111	TRUE	TRUE
ENSG00000243649.9	.	BCM	GRCh38.p13	chr6	31947393	31947393	+	T	T	C	Missense_Mutation	SNP	ENST00000425368.7	exon4	c.T530C	p.V177A	exonic	ENSG00000243649.9;ENSG00000244255.5	.	nonsynonymous SNV	ENSG00000243649.9:ENST00000425368.7:exon4:c.T530C:p.V177A,ENSG00000244255.5:ENST00000456570.5:exon16:c.T2036C:p.V679A	6p21.33	C3L-03123	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.095	T	T	T	0.041	0.525	0.126	0.572	T	T	T	T	T	T	2.120	20.300	0.965	N	D	-0.504	1.168	-0.356	1.453	1.000	0.554	0.514	0.514	0.568	.	4.930	0.996	0.421	1.049	0.665	0.999	1.000	0.997	923	Sushi/SCR/CCP_domain	.	.	.	CFB	780	0	840	121	0.125910509885536	TRUE	TRUE
ENSG00000157343.8	.	BCM	GRCh38.p13	chr6	35747379	35747379	+	G	G	A	Missense_Mutation	SNP	ENST00000373866.3	exon4	c.G563A	p.R188Q	exonic	ENSG00000157343.8	.	nonsynonymous SNV	ENSG00000157343.8:ENST00000373866.3:exon4:c.G563A:p.R188Q	6p21.31	C3L-03123	2.471e-05	0	0	0	0	0	0	0.0002	rs756954794	8.20	T	D	D	P	D	D	M	T	N	0.709	T	T	T	0.276	0.691	0.772	0.549	T	T	T	T	D	D	3.964	26.700	0.999	D	N	0.273	3.646	0.304	3.741	0.561	0.706	0.634	0.710	0.616	.	4.470	4.470	3.722	1.176	0.676	1.000	0.995	0.997	675	Armadillo_repeat-containing_domain	.	.	ID=COSV55362032;OCCURENCE=1(stomach)	ARMC12	401	0	492	49	0.0905730129390018	TRUE	TRUE
ENSG00000112139.16	.	BCM	GRCh38.p13	chr6	37650144	37650144	+	C	C	T	Missense_Mutation	SNP	ENST00000434837.8	exon8	c.G1574A	p.R525H	exonic	ENSG00000112139.16	.	nonsynonymous SNV	ENSG00000112139.16:ENST00000434837.8:exon8:c.G1574A:p.R525H	6p21.2	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	T	D	D	P	N	D	N	T	N	0.405	T	T	T	0.148	0.488	0.654	1.863	T	T	T	T	D	D	3.645	25.200	0.999	D	N	0.421	4.478	0.404	4.390	1.000	0.598	0.541	0.378	0.639	.	3.920	3.920	3.757	1.026	0.599	1.000	0.978	0.980	892	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV51801910;OCCURENCE=1(large_intestine)	MDGA1	199	0	246	25	0.0922509225092251	TRUE	TRUE
ENSG00000112624.12	.	BCM	GRCh38.p13	chr6	42829660	42829660	+	A	A	G	Missense_Mutation	SNP	ENST00000314073.9	exon6	c.A1327G	p.M443V	exonic	ENSG00000112624.12	.	nonsynonymous SNV	ENSG00000112624.12:ENST00000314073.9:exon6:c.A1327G:p.M443V	6p21.1	C3L-03123	.	.	.	.	.	.	.	.	.	8.19	D	T	B	P	D	D	.	T	N	0.646	T	T	T	0.154	0.428	0.155	0.789	T	T	D	D	D	D	2.676	22.800	0.993	D	N	0.314	3.852	0.420	4.501	0.999	0.707	0.702	0.725	0.636	.	5.870	5.870	4.867	1.307	0.751	1.000	1.000	1.000	435	.	.	.	.	BICRAL	359	0	390	60	0.133333333333333	TRUE	TRUE
ENSG00000112782.19	.	BCM	GRCh38.p13	chr6	45941583	45941583	+	C	C	T	Missense_Mutation	SNP	ENST00000185206.12	exon4	c.G847A	p.A283T	exonic	ENSG00000112782.19	.	nonsynonymous SNV	ENSG00000112782.19:ENST00000185206.12:exon4:c.G847A:p.A283T	6p21.1	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	P	B	D	D	M	D	D	0.883	D	D	D	0.774	0.662	0.976	0.237	T	T	D	D	D	D	3.277	24.100	0.998	D	D	0.582	5.741	0.600	6.220	1.000	0.554	0.574	0.602	0.564	.	5.440	5.440	7.844	0.947	0.599	1.000	0.999	0.994	867	Glutathione_S-transferase,_C-terminal-like	.	.	.	CLIC5	421	0	542	54	0.0906040268456376	TRUE	TRUE
ENSG00000082269.16	.	BCM	GRCh38.p13	chr6	70559755	70559755	+	C	C	T	Missense_Mutation	SNP	ENST00000418814.6	exon22	c.C4382T	p.P1461L	exonic	ENSG00000082269.16	.	nonsynonymous SNV	ENSG00000082269.16:ENST00000418814.6:exon22:c.C4382T:p.P1461L	6q13	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.843	T	T	D	0.483	0.758	0.629	0.769	T	T	D	D	D	D	3.233	23.900	0.999	D	D	0.728	7.526	0.651	6.920	1.000	0.638	0.634	0.659	0.668	.	5.410	5.410	7.905	1.026	0.549	1.000	0.122	0.046	783	.	.	.	.	FAM135A	382	0	335	43	0.113756613756614	TRUE	TRUE
ENSG00000079841.18	.	BCM	GRCh38.p13	chr6	72251255	72251255	+	C	C	T	Missense_Mutation	SNP	ENST00000521978.5	exon15	c.C2585T	p.P862L	exonic	ENSG00000079841.18	.	nonsynonymous SNV	ENSG00000079841.18:ENST00000521978.5:exon15:c.C2585T:p.P862L	6q13	C3L-03123	0	0	0	0	0	0	0	0	rs771037675	18.20	D	D	D	D	D	D	M	T	D	0.849	D	T	D	0.633	0.392	0.833	0.637	D	D	D	D	D	D	3.769	25.700	0.999	D	D	0.661	6.611	0.676	7.326	1.000	0.554	0.574	0.602	0.613	.	5.550	5.550	7.871	0.877	0.549	1.000	0.864	0.846	888	C2_domain	.	.	ID=COSV53462859;OCCURENCE=1(large_intestine)	RIMS1	299	0	318	28	0.0809248554913295	TRUE	NA
ENSG00000188994.13	.	BCM	GRCh38.p13	chr6	87260895	87260897	+	TCT	TCT	-	In_Frame_Del	DEL	ENST00000369577.8	exon8	c.7266_7268del	p.L2424del	exonic	ENSG00000188994.13	.	nonframeshift deletion	ENSG00000188994.13:ENST00000369577.8:exon8:c.7266_7268del:p.L2424del	6q14.3	C3L-03123	2.979e-05	0	0	0	0.0002	3.586e-05	0	0	rs756631142	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF292	213	0	215	23	0.0966386554621849	TRUE	TRUE
ENSG00000164414.18	.	BCM	GRCh38.p13	chr6	87509115	87509115	+	G	G	A	Missense_Mutation	SNP	ENST00000369552.9	exon7	c.G826A	p.A276T	exonic	ENSG00000164414.18	.	nonsynonymous SNV	ENSG00000164414.18:ENST00000369552.9:exon7:c.G826A:p.A276T	6q15	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	U	D	N	T	N	0.855	T	T	T	0.277	0.625	0.354	0.373	T	T	T	T	D	D	2.951	23.300	0.905	D	D	0.073	2.781	0.271	3.554	1.000	0.707	0.725	0.576	0.714	.	5.300	5.300	9.516	1.176	0.618	1.000	0.998	0.996	809	.	.	.	.	SLC35A1	618	0	626	83	0.117066290550071	TRUE	TRUE
ENSG00000178409.13	.	BCM	GRCh38.p13	chr6	107070128	107070128	+	C	C	T	Missense_Mutation	SNP	ENST00000429433.3	exon5	c.G1063A	p.A355T	exonic	ENSG00000178409.13	.	nonsynonymous SNV	ENSG00000178409.13:ENST00000429433.3:exon5:c.G1063A:p.A355T	6q21	C3L-03123	6.833e-05	0	0	0.0006	0	3.138e-05	0	6.075e-05	rs199991434	0.19	T	T	B	B	N	N	N	.	N	0.011	T	T	T	0.034	.	0.150	0.478	T	T	T	T	T	T	-0.961	0.010	0.757	N	N	-1.733	0.032	-1.806	0.033	1.000	0.707	0.546	0.725	0.528	.	5.110	-10.200	-0.908	-1.402	-1.091	0.000	0.042	0.053	634	.	.	.	.	BEND3	347	0	421	46	0.0985010706638116	TRUE	NA
ENSG00000203797.11	.	BCM	GRCh38.p13	chr6	110392872	110392872	+	C	C	-	Frame_Shift_Del	DEL	ENST00000368924.8	exon5	c.1013delG	p.G338Afs*16	exonic	ENSG00000203797.11	.	frameshift deletion	ENSG00000203797.11:ENST00000368924.8:exon5:c.1013delG:p.G338Afs*16	6q21	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DDO	179	0	203	28	0.121212121212121	TRUE	NA
ENSG00000112769.20	.	BCM	GRCh38.p13	chr6	112132797	112132797	+	G	G	A	Nonsense_Mutation	SNP	ENST00000230538.12	exon28	c.C3790T	p.R1264X	exonic	ENSG00000112769.20	.	stopgain	ENSG00000112769.20:ENST00000230538.12:exon28:c.C3790T:p.R1264X	6q21	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.956	.	.	.	.	.	.	.	.	.	D	D	.	.	8.529	43	0.998	D	N	0.947	12.338	0.847	11.647	1.000	0.672	0.574	0.574	0.711	.	6.070	6.070	5.555	1.176	0.676	1.000	1.000	0.993	669	Laminin_G_domain	.	.	ID=COSV57899815;OCCURENCE=1(biliary_tract)	LAMA4	303	0	337	34	0.091644204851752	TRUE	TRUE
ENSG00000111875.8	.	BCM	GRCh38.p13	chr6	118907486	118907486	+	G	G	A	Missense_Mutation	SNP	ENST00000229595.6	exon4	c.G487A	p.A163T	exonic	ENSG00000111875.8	.	nonsynonymous SNV	ENSG00000111875.8:ENST00000229595.6:exon4:c.G487A:p.A163T	6q22.31	C3L-03123	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	D	D	N	.	N	0.054	T	T	T	0.062	0.137	0.266	0.819	T	T	T	T	T	T	1.891	18.420	0.860	D	N	-0.529	1.120	-0.270	1.628	0.999	0.707	0.725	0.725	0.714	.	5.910	5.050	1.963	-0.127	-0.119	1.000	0.998	0.997	488	.	.	.	.	ASF1A	301	0	378	23	0.057356608478803	TRUE	TRUE
ENSG00000111961.18	.	BCM	GRCh38.p13	chr6	148546090	148546090	+	G	G	A	Missense_Mutation	SNP	ENST00000367467.8	exon19	c.G3424A	p.A1142T	exonic	ENSG00000111961.18	.	nonsynonymous SNV	ENSG00000111961.18:ENST00000367467.8:exon19:c.G3424A:p.A1142T	6q25.1	C3L-03123	4.127e-05	0	0.0004	0	0	0	0	0	rs769622545	10.20	D	D	D	B	D	D	N	T	N	0.933	T	T	T	0.281	0.144	0.656	0.636	T	T	T	D	D	D	3.170	23.800	0.999	D	D	0.450	4.669	0.528	5.420	1.000	0.732	0.610	0.744	0.711	.	5.460	5.460	7.540	1.083	0.676	1.000	0.978	0.952	958	.	.	.	ID=COSV66562621;OCCURENCE=1(large_intestine)	SASH1	237	1	318	17	0.0507462686567164	TRUE	NA
ENSG00000131023.13	.	BCM	GRCh38.p13	chr6	149680118	149680118	+	A	A	G	Missense_Mutation	SNP	ENST00000543571.6	exon5	c.T2350C	p.Y784H	exonic	ENSG00000131023.13	.	nonsynonymous SNV	ENSG00000131023.13:ENST00000543571.6:exon5:c.T2350C:p.Y784H	6q25.1	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.927	T	T	D	0.666	0.908	0.884	2.026	D	T	D	D	D	D	4.114	27.900	0.999	D	D	0.767	8.169	0.761	9.064	1.000	0.707	0.654	0.659	0.714	.	5.500	5.500	9.325	1.308	0.756	1.000	1.000	0.997	416	Protein_kinase_domain	.	.	.	LATS1	129	0	136	12	0.0810810810810811	TRUE	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152463478	152463478	+	T	T	C	Missense_Mutation	SNP	ENST00000367255.10	exon19	c.A1972G	p.T658A	exonic	ENSG00000131018.24	.	nonsynonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon19:c.A1972G:p.T658A	6q25.2	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.129	T	T	T	0.029	0.259	0.130	0.130	T	T	T	T	T	T	1.339	14.670	0.543	D	N	-1.109	0.298	-1.009	0.477	1.000	0.554	0.590	0.618	0.613	.	5.560	-3.000	1.792	-0.150	-0.164	1.000	0.742	0.964	699	.	.	.	.	SYNE1	466	0	520	34	0.0613718411552347	TRUE	TRUE
ENSG00000130338.13	.	BCM	GRCh38.p13	chr6	158502352	158502352	+	G	G	A	Missense_Mutation	SNP	ENST00000367097.8	exon13	c.G2689A	p.V897M	exonic	ENSG00000130338.13	.	nonsynonymous SNV	ENSG00000130338.13:ENST00000367097.8:exon13:c.G2689A:p.V897M	6q25.3	C3L-03123	8.327e-06	0	0	0	0	1.52e-05	0	0	rs770190031	14.20	D	T	D	D	D	D	M	T	N	0.776	T	T	D	0.362	0.222	0.610	0.852	D	T	D	D	D	D	3.758	25.600	0.999	D	D	0.815	9.087	0.792	9.877	1.000	0.646	0.654	0.645	0.636	.	5.120	5.120	9.013	1.075	0.672	1.000	0.960	0.924	693	.	.	.	.	TULP4	300	0	351	21	0.0564516129032258	TRUE	NA
ENSG00000130338.13	.	BCM	GRCh38.p13	chr6	158502496	158502496	+	C	C	T	Missense_Mutation	SNP	ENST00000367097.8	exon13	c.C2833T	p.R945C	exonic	ENSG00000130338.13	.	nonsynonymous SNV	ENSG00000130338.13:ENST00000367097.8:exon13:c.C2833T:p.R945C	6q25.3	C3L-03123	4.975e-05	0	0	0	0	7.555e-05	0	6.058e-05	rs367875154	14.20	D	D	D	D	D	D	M	T	D	0.829	T	T	D	0.461	.	0.362	1.001	D	T	D	D	T	D	3.822	25.900	0.999	D	N	0.559	5.527	0.514	5.290	0.735	0.646	0.546	0.645	0.636	.	4.490	4.490	2.031	0.940	0.596	1.000	0.988	0.999	693	.	.	.	ID=COSV65582646;OCCURENCE=1(biliary_tract)	TULP4	249	0	310	23	0.0690690690690691	TRUE	TRUE
ENSG00000106012.18	.	BCM	GRCh38.p13	chr7	2578266	2578266	+	G	G	A	Missense_Mutation	SNP	ENST00000402050.7	exon7	c.G490A	p.V164M	exonic	ENSG00000106012.18	.	nonsynonymous SNV	ENSG00000106012.18:ENST00000402050.7:exon7:c.G490A:p.V164M	7p22.3	C3L-03123	9.138e-05	0	0	0	0	0.0002	0	0	rs749622221	3.20	T	T	D	D	N	N	L	T	N	0.219	T	T	T	0.037	0.274	0.194	0.251	T	T	T	T	T	T	1.459	15.470	0.997	D	N	0.128	3.000	-0.023	2.282	0.100	0.646	0.602	0.645	0.636	.	5.500	3.680	1.741	-0.124	-0.113	0.966	0.240	0.112	873	.	.	.	ID=COSV100383649;OCCURENCE=1(endometrium)	IQCE	351	0	412	45	0.0984682713347921	TRUE	NA
ENSG00000106346.11	.	BCM	GRCh38.p13	chr7	6139110	6139110	+	G	G	A	Missense_Mutation	SNP	ENST00000306177.9	exon5	c.G572A	p.R191H	exonic	ENSG00000106346.11	.	nonsynonymous SNV	ENSG00000106346.11:ENST00000306177.9:exon5:c.G572A:p.R191H	7p22.1	C3L-03123	1.369e-05	0	0	0	0	2.556e-05	0	0	rs763773392	9.20	T	T	P	B	D	D	L	T	D	0.126	T	T	T	0.289	0.559	0.416	1.648	T	T	D	D	D	D	2.830	23.100	0.998	D	D	0.540	5.362	0.587	6.060	1.000	0.651	0.654	0.651	0.636	.	5.440	5.440	5.419	1.155	0.676	1.000	0.994	0.998	646	Ubiquitin_specific_protease_domain;Peptidase_C19,_ubiquitin_carboxyl-terminal_hydrolase	.	.	ID=COSV60362082;OCCURENCE=1(large_intestine)	USP42	205	0	228	24	0.0952380952380952	TRUE	TRUE
ENSG00000105877.18	.	BCM	GRCh38.p13	chr7	21773803	21773803	+	A	A	G	Missense_Mutation	SNP	ENST00000409508.8	exon56	c.A9140G	p.H3047R	exonic	ENSG00000105877.18	.	nonsynonymous SNV	ENSG00000105877.18:ENST00000409508.8:exon56:c.A9140G:p.H3047R	7p15.3	C3L-03123	.	.	.	.	.	.	.	.	.	6.16	D	.	.	.	N	N	.	T	D	0.592	T	T	D	0.203	0.487	0.391	.	T	T	T	T	D	D	2.680	22.800	0.983	D	N	0.192	3.266	0.165	3.019	0.778	0.554	0.590	0.602	0.542	.	5.730	4.470	3.808	1.311	0.756	0.860	0.353	0.203	829	Dynein_heavy_chain,_AAA_module_D4	.	.	.	DNAH11	155	0	172	21	0.10880829015544	TRUE	TRUE
ENSG00000105996.7	.	BCM	GRCh38.p13	chr7	27102321	27102321	+	G	G	T	Missense_Mutation	SNP	ENST00000222718.7	exon1	c.C180A	p.N60K	exonic	ENSG00000105996.7	.	nonsynonymous SNV	ENSG00000105996.7:ENST00000222718.7:exon1:c.C180A:p.N60K	7p15.2	C3L-03123	.	.	.	.	.	.	.	.	.	11.20	T	T	P	P	D	D	M	D	N	0.494	D	D	D	0.569	0.312	0.972	1.502	D	T	T	T	D	T	2.813	23.000	0.997	D	D	0.522	5.210	0.518	5.328	1.000	0.598	0.590	0.596	0.492	.	5.350	5.350	1.046	0.227	-0.161	1.000	1.000	0.988	436	.	.	.	.	HOXA2	460	0	481	70	0.127041742286751	TRUE	TRUE
ENSG00000106571.14	.	BCM	GRCh38.p13	chr7	41965523	41965523	+	C	C	T	Missense_Mutation	SNP	ENST00000395925.8	exon15	c.G3550A	p.A1184T	exonic	ENSG00000106571.14	.	nonsynonymous SNV	ENSG00000106571.14:ENST00000395925.8:exon15:c.G3550A:p.A1184T	7p14.1	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.038	T	T	D	0.033	0.181	0.206	0.281	T	T	T	T	T	T	-1.366	0.001	0.894	N	N	-1.601	0.055	-1.741	0.043	1.000	0.719	0.574	0.723	0.492	.	5.350	-10.700	-3.579	-0.854	-0.233	0.000	0.000	0.001	938	.	.	.	ID=COSV67890876;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue)	GLI3	138	0	171	21	0.109375	TRUE	TRUE
ENSG00000164659.15	.	BCM	GRCh38.p13	chr7	86926771	86926771	+	G	G	T	Missense_Mutation	SNP	ENST00000450689.7	exon9	c.C1235A	p.P412H	exonic	ENSG00000164659.15	.	nonsynonymous SNV	ENSG00000164659.15:ENST00000450689.7:exon9:c.C1235A:p.P412H	7q21.12	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.813	T	T	D	0.341	0.449	0.447	0.888	T	T	D	T	D	D	4.078	27.600	0.997	D	D	0.774	8.302	0.756	8.949	1.000	0.778	0.567	0.780	0.826	.	5.530	5.530	8.120	1.176	0.676	1.000	1.000	0.990	587	Tyrosine-protein_kinase_ephrin_type_A/B_receptor-like	.	.	.	KIAA1324L	119	0	134	11	0.0758620689655172	TRUE	TRUE
ENSG00000085563.15	.	BCM	GRCh38.p13	chr7	87544903	87544903	+	G	G	C	Missense_Mutation	SNP	ENST00000622132.5	exon16	c.C1984G	p.L662V	exonic	ENSG00000085563.15	.	nonsynonymous SNV	ENSG00000085563.15:ENST00000622132.5:exon16:c.C1984G:p.L662V	7q21.12	C3L-03123	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	N	M	D	N	0.136	T	T	T	0.297	0.251	0.600	0.211	T	.	T	T	T	T	1.365	14.840	0.991	N	N	-0.500	1.177	-0.390	1.391	0.000	0.554	0.588	0.574	0.621	.	5.420	1.230	0.219	0.222	0.676	0.633	0.998	0.996	499	.	.	.	.	ABCB1	309	0	384	46	0.106976744186047	TRUE	TRUE
ENSG00000157240.4	.	BCM	GRCh38.p13	chr7	91266784	91266784	+	C	C	T	Missense_Mutation	SNP	ENST00000287934.4	exon1	c.C1904T	p.T635M	exonic	ENSG00000157240.4	.	nonsynonymous SNV	ENSG00000157240.4:ENST00000287934.4:exon1:c.C1904T:p.T635M	7q21.13	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	T	T	P	B	D	D	L	D	N	0.422	T	T	D	0.442	0.371	0.905	.	T	T	T	T	D	D	2.709	22.800	0.984	D	D	0.095	2.868	0.197	3.168	1.000	0.624	0.627	0.504	0.580	.	4.890	4.890	2.023	1.022	0.596	0.998	0.989	0.971	603	Frizzled/Smoothened,_transmembrane_domain	.	.	.	FZD1	74	0	114	14	0.109375	TRUE	TRUE
ENSG00000001629.10	.	BCM	GRCh38.p13	chr7	92307411	92307411	+	A	A	C	Missense_Mutation	SNP	ENST00000265742.8	exon3	c.A241C	p.T81P	exonic	ENSG00000001629.10	.	nonsynonymous SNV	ENSG00000001629.10:ENST00000265742.8:exon3:c.A241C:p.T81P	7q21.2	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	L	T	D	0.729	T	T	D	0.819	0.798	0.952	1.967	T	T	D	D	D	D	3.956	26.700	0.996	D	D	0.657	6.562	0.692	7.600	1.000	0.706	0.725	0.710	0.613	.	5.440	5.440	8.910	1.311	0.689	1.000	1.000	0.999	508	Ankyrin_repeat-containing_domain	.	.	.	ANKIB1	296	1	260	36	0.121621621621622	TRUE	TRUE
ENSG00000242950.7	.	BCM	GRCh38.p13	chr7	92470306	92470306	+	G	G	A	Missense_Mutation	SNP	ENST00000603053.2	exon2	c.C76T	p.R26C	exonic	ENSG00000242950.7	.	nonsynonymous SNV	ENSG00000242950.7:ENST00000603053.2:exon2:c.C76T:p.R26C	7q21.2	C3L-03123	0.0013	0.0016	8.684e-05	0	0.0005	0.0019	0.0012	0	rs138779740	0.16	T	T	.	.	.	N	.	T	N	0.184	T	T	T	0.053	.	0.150	0.450	T	T	T	T	T	T	1.438	15.340	0.957	N	N	-0.652	0.896	-0.752	0.826	0.000	0.487	0.547	0.547	0.564	.	0.046	0.046	0.171	0.170	0.171	0.773	0.638	0.655	616	.	.	.	ID=COSV71259637;OCCURENCE=1(large_intestine)	ERVW-1	75	0	84	10	0.106382978723404	NA	TRUE
ENSG00000106351.13	.	BCM	GRCh38.p13	chr7	100562667	100562667	+	G	G	T	Missense_Mutation	SNP	ENST00000300176.9	exon8	c.G1072T	p.G358W	exonic	ENSG00000106351.13	.	nonsynonymous SNV	ENSG00000106351.13:ENST00000300176.9:exon8:c.G1072T:p.G358W	7q22.1	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	D	D	D	D	N	N	M	T	N	0.667	T	T	T	0.131	0.384	0.271	1.073	T	T	T	T	D	T	3.330	24.200	0.995	N	N	-0.226	1.805	-0.309	1.546	0.997	0.672	0.702	0.490	0.636	.	5.000	3.200	1.113	1.176	0.676	0.013	0.962	0.965	.	.	.	.	.	AGFG2	164	0	195	23	0.105504587155963	TRUE	TRUE
ENSG00000087087.20	.	BCM	GRCh38.p13	chr7	100884111	100884111	+	G	G	T	Missense_Mutation	SNP	ENST00000611405.5	exon6	c.G629T	p.R210L	exonic	ENSG00000087087.20	.	nonsynonymous SNV	ENSG00000087087.20:ENST00000611405.5:exon6:c.G629T:p.R210L	7q22.1	C3L-03123	8.248e-06	0	0	0	0	1.501e-05	0	0	rs777364262	7.17	.	T	P	B	D	D	L	.	.	0.608	T	T	T	0.152	0.400	0.043	.	T	D	T	T	D	D	2.855	23.100	0.991	D	D	-0.023	2.431	0.059	2.571	1.000	0.672	0.698	0.702	0.711	.	3.900	3.000	3.179	1.176	0.618	1.000	1.000	0.995	692	SERRATE/Ars2,_N-terminal	.	.	.	SRRT	148	0	179	21	0.105	TRUE	NA
ENSG00000169871.13	.	BCM	GRCh38.p13	chr7	101088412	101088412	+	G	G	A	Missense_Mutation	SNP	ENST00000306085.11	exon3	c.G1100A	p.R367Q	exonic	ENSG00000169871.13	.	nonsynonymous SNV	ENSG00000169871.13:ENST00000306085.11:exon3:c.G1100A:p.R367Q	7q22.1	C3L-03123	4.716e-05	0	0	0	0	8.372e-05	0	0	rs763535074	0.19	T	T	B	B	.	N	N	T	N	0.030	T	T	T	0.037	0.427	0.245	0.594	T	T	T	T	T	T	-0.109	0.794	0.642	N	N	-1.635	0.048	-1.627	0.068	1.000	0.632	0.698	0.723	0.636	.	3.460	0.095	-0.643	0.226	-0.109	0.000	0.482	0.711	840	.	.	.	.	TRIM56	100	0	97	12	0.110091743119266	TRUE	NA
ENSG00000160999.10	.	BCM	GRCh38.p13	chr7	102301173	102301173	+	C	C	T	Missense_Mutation	SNP	ENST00000536178.3	exon2	c.C752T	p.A251V	exonic	ENSG00000160999.10	.	nonsynonymous SNV	ENSG00000160999.10:ENST00000536178.3:exon2:c.C752T:p.A251V	7q22.1	C3L-03123	.	.	.	.	.	.	.	.	.	7.15	D	D	.	.	N	.	.	T	N	0.260	T	T	D	0.078	0.395	0.639	0.287	D	.	T	T	D	T	2.113	20.200	0.997	D	D	0.071	2.772	0.087	2.681	1.000	0.789	0.702	0.768	0.767	.	3.370	3.370	4.500	0.896	0.450	0.991	0.623	0.293	759	.	.	.	ID=COSV60825846;OCCURENCE=1(breast),1(large_intestine)	SH2B2	256	0	307	34	0.0997067448680352	TRUE	TRUE
ENSG00000001626.16	.	BCM	GRCh38.p13	chr7	117603579	117603579	+	G	G	A	Missense_Mutation	SNP	ENST00000003084.11	exon17	c.G2705A	p.S902N	exonic	ENSG00000001626.16	.	nonsynonymous SNV	ENSG00000001626.16:ENST00000003084.11:exon17:c.G2705A:p.S902N	7q31.2	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	L	D	N	0.195	T	D	D	0.235	0.601	0.953	0.004	T	T	T	T	T	T	0.686	8.325	0.956	N	N	-0.768	0.703	-0.780	0.786	0.204	0.615	0.574	0.659	0.564	.	5.820	2.690	0.203	0.169	0.618	0.001	0.283	0.576	852	ABC_transporter_type_1,_transmembrane_domain	.	.	.	CFTR	455	0	468	51	0.0982658959537572	TRUE	TRUE
ENSG00000230626.4	.	BCM	GRCh38.p13	chr7	129127329	129127329	+	C	C	T	Missense_Mutation	SNP	ENST00000467614.2	exon1	c.C812T	p.A271V	exonic	ENSG00000230626.4	.	nonsynonymous SNV	ENSG00000230626.4:ENST00000467614.2:exon1:c.C812T:p.A271V	7q32.1	C3L-03123	.	.	.	.	.	.	.	.	.	2.2	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	D	1.263	14.110	0.871	D	.	.	.	.	.	0.008	0.096	0.097	0.105	0.091	0.610	2.170	1.250	5.624	0.152	0.394	1.000	0.090	0.217	448	.	.	.	.	AC011005.1	554	1	578	71	0.10939907550077	NA	TRUE
ENSG00000158525.15	.	BCM	GRCh38.p13	chr7	130362909	130362909	+	G	G	A	Missense_Mutation	SNP	ENST00000485477.5	exon8	c.G662A	p.R221H	exonic	ENSG00000158525.15	.	nonsynonymous SNV	ENSG00000158525.15:ENST00000485477.5:exon8:c.G662A:p.R221H	7q32.2	C3L-03123	.	.	.	.	.	.	.	.	rs530926535	0.20	T	T	B	B	N	N	L	T	N	0.193	T	T	T	0.014	.	0.136	0.219	T	T	T	T	T	T	-0.179	0.565	0.889	N	N	-2.105	0.005	-2.201	0.005	1.000	0.554	0.588	0.547	0.613	.	5.490	-11.000	-0.161	-1.643	-1.715	0.000	0.001	0.098	622	Peptidase_M14,_carboxypeptidase_A	.	.	ID=COSV62570788;OCCURENCE=1(upper_aerodigestive_tract)	CPA5	155	0	172	20	0.104166666666667	TRUE	TRUE
ENSG00000013374.16	.	BCM	GRCh38.p13	chr7	151351478	151351478	+	T	T	C	Missense_Mutation	SNP	ENST00000470229.6	exon4	c.T340C	p.S114P	exonic	ENSG00000013374.16	.	nonsynonymous SNV	ENSG00000013374.16:ENST00000470229.6:exon4:c.T340C:p.S114P	7q36.1	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	D	D	P	B	N	D	L	T	N	0.664	T	T	D	0.164	0.378	0.442	0.787	T	T	T	T	D	T	2.805	23.000	0.997	D	N	0.090	2.848	0.059	2.571	1.000	0.731	0.750	0.636	0.714	.	5.430	2.850	0.797	1.138	0.665	0.993	0.986	0.994	946	.	.	.	.	NUB1	114	0	154	17	0.0994152046783626	NA	TRUE
ENSG00000180190.11	.	BCM	GRCh38.p13	chr8	492446	492446	+	G	G	A	Missense_Mutation	SNP	ENST00000613071.1	exon4	c.C511T	p.R171W	exonic	ENSG00000180190.11	.	nonsynonymous SNV	ENSG00000180190.11:ENST00000613071.1:exon4:c.C511T:p.R171W	8p23.3	C3L-03123	1.157e-05	0	0	0	0	2.004e-05	0	0	rs773185041	14.18	D	D	D	D	D	D	M	.	D	0.811	T	T	D	0.392	0.509	0.260	.	.	T	D	D	D	D	1.467	15.530	0.998	D	N	0.068	2.762	-0.058	2.170	0.585	0.719	0.547	0.723	0.621	.	6.080	4.240	3.517	0.155	-0.154	0.991	0.017	0.011	958	.	.	.	ID=COSV100138523;OCCURENCE=1(biliary_tract)	TDRP	140	0	153	23	0.130681818181818	TRUE	NA
ENSG00000236125.3	.	BCM	GRCh38.p13	chr8	7338091	7338091	+	C	C	T	Missense_Mutation	SNP	ENST00000526929.1	exon1	c.C977T	p.A326V	exonic	ENSG00000236125.3	.	nonsynonymous SNV	ENSG00000236125.3:ENST00000526929.1:exon1:c.C977T:p.A326V	8p23.1	C3L-03123	.	.	.	.	.	.	.	.	.	0.8	.	T	.	.	.	.	N	.	.	0.161	.	.	.	.	.	0.076	.	T	T	T	T	.	T	0.866	10.080	0.757	N	.	.	.	.	.	0.000	0.061	0.063	0.063	0.057	0.082	0.488	0.488	1.601	0.467	0.405	0.207	0.016	0.026	994	Ubiquitin_specific_protease_domain;Peptidase_C19,_ubiquitin_carboxyl-terminal_hydrolase	.	.	.	USP17L4	841	0	846	102	0.107594936708861	NA	TRUE
ENSG00000183638.6	.	BCM	GRCh38.p13	chr8	10610941	10610941	+	C	C	T	Missense_Mutation	SNP	ENST00000382483.4	exon4	c.G3157A	p.E1053K	exonic	ENSG00000183638.6	.	nonsynonymous SNV	ENSG00000183638.6:ENST00000382483.4:exon4:c.G3157A:p.E1053K	8p23.1	C3L-03123	0.0002	0.0024	0	0	0	1.774e-05	0	0.0003	rs139223185	1.18	T	T	.	.	N	N	N	T	N	0.091	T	T	D	0.072	.	0.099	.	T	T	T	T	T	T	-0.191	0.534	0.944	N	N	-1.169	0.249	-1.236	0.254	0.000	0.487	0.574	0.578	0.563	.	4.600	-2.930	-0.322	-0.950	-0.259	0.000	0.000	0.000	793	.	.	.	ID=COSV66755946;OCCURENCE=1(large_intestine)	RP1L1	333	0	346	37	0.0966057441253264	TRUE	TRUE
ENSG00000003989.18	.	BCM	GRCh38.p13	chr8	17562031	17562031	+	C	C	T	Missense_Mutation	SNP	ENST00000494857.6	exon11	c.C1592T	p.A531V	exonic	ENSG00000003989.18	.	nonsynonymous SNV	ENSG00000003989.18:ENST00000494857.6:exon11:c.C1592T:p.A531V	8p22	C3L-03123	4.119e-05	0	0	0	0	7.493e-05	0	0	rs772998799	1.20	T	T	B	B	N	N	N	D	N	0.087	T	T	T	0.174	0.323	0.564	0.021	T	T	T	T	T	T	-0.472	0.136	0.291	N	N	-1.424	0.107	-1.437	0.134	0.928	0.732	0.574	0.744	0.714	.	4.830	-2.740	0.687	-3.265	-1.584	0.006	0.000	0.015	840	.	.	.	ID=COSV50262885;OCCURENCE=1(large_intestine),1(endometrium)	SLC7A2	325	1	416	37	0.0816777041942605	TRUE	TRUE
ENSG00000104613.12	.	BCM	GRCh38.p13	chr8	19832058	19832058	+	C	C	T	Missense_Mutation	SNP	ENST00000397977.8	exon11	c.C1325T	p.T442M	exonic	ENSG00000104613.12	.	nonsynonymous SNV	ENSG00000104613.12:ENST00000397977.8:exon11:c.C1325T:p.T442M	8p21.3	C3L-03123	7.454e-05	0	0	0	0.0003	0.0001	0	0	rs200006596	12.19	D	D	D	D	D	D	M	.	N	0.774	T	T	T	0.353	0.653	0.384	0.541	T	T	D	D	T	D	3.405	24.400	0.999	D	D	0.773	8.284	0.797	10.023	1.000	0.707	0.725	0.725	0.714	.	5.820	5.820	7.459	1.008	0.599	1.000	0.997	0.967	865	.	.	.	.	INTS10	298	0	341	36	0.0954907161803713	TRUE	NA
ENSG00000167034.10	.	BCM	GRCh38.p13	chr8	23681400	23681400	+	G	G	A	Missense_Mutation	SNP	ENST00000380871.5	exon2	c.C526T	p.R176C	exonic	ENSG00000167034.10	.	nonsynonymous SNV	ENSG00000167034.10:ENST00000380871.5:exon2:c.C526T:p.R176C	8p21.2	C3L-03123	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.890	D	D	D	0.894	0.933	0.992	0.920	D	D	D	D	D	D	4.405	31	0.999	D	D	1.015	14.409	0.903	13.882	1.000	0.443	0.590	0.666	0.530	.	5.660	5.660	2.712	1.176	0.676	1.000	1.000	0.997	783	Homeobox_domain,_metazoa;Homeobox,_conserved_site;Homeobox_domain	.	.	ID=COSV66512049;OCCURENCE=1(liver),3(large_intestine),1(biliary_tract)	NKX3-1	320	0	445	36	0.0748440748440748	TRUE	TRUE
ENSG00000104228.13	.	BCM	GRCh38.p13	chr8	27287831	27287831	+	G	G	A	Missense_Mutation	SNP	ENST00000305364.9	exon6	c.C1201T	p.R401C	exonic	ENSG00000104228.13	.	nonsynonymous SNV	ENSG00000104228.13:ENST00000305364.9:exon6:c.C1201T:p.R401C	8p21.2	C3L-03123	9.76e-06	0	0	0	0	1.756e-05	0	0	rs377763568	10.20	T	T	D	D	D	D	L	T	N	0.334	T	T	D	0.365	.	0.831	1.487	T	T	D	D	D	T	4.371	31	0.999	D	D	0.667	6.681	0.657	7.021	1.000	0.732	0.702	0.744	0.714	.	5.550	5.550	3.298	1.101	0.590	1.000	0.999	0.915	635	0.000	.	.	ID=COSV59523637;OCCURENCE=1(oesophagus)	TRIM35	316	2	370	42	0.101941747572816	TRUE	TRUE
ENSG00000169499.15	.	BCM	GRCh38.p13	chr8	38969509	38969509	+	G	G	A	Missense_Mutation	SNP	ENST00000617275.5	exon12	c.G1004A	p.R335Q	exonic	ENSG00000169499.15	.	nonsynonymous SNV	ENSG00000169499.15:ENST00000617275.5:exon12:c.G1004A:p.R335Q	8p11.22	C3L-03123	1.801e-05	0	0	0	0	3.255e-05	0	0	rs376761444	5.16	.	T	D	B	N	D	.	.	.	0.373	T	T	T	0.106	.	0.356	.	T	T	T	T	T	D	2.940	23.300	0.995	D	D	0.277	3.664	0.316	3.813	1.000	0.707	0.725	0.602	0.568	.	5.910	5.910	3.629	1.176	0.676	1.000	0.205	0.525	636	.	.	.	ID=COSV56760240;OCCURENCE=2(biliary_tract)	PLEKHA2	576	0	657	71	0.0975274725274725	TRUE	NA
ENSG00000171316.12	.	BCM	GRCh38.p13	chr8	60852139	60852139	+	T	T	C	Missense_Mutation	SNP	ENST00000423902.7	exon29	c.T5786C	p.M1929T	exonic	ENSG00000171316.12	.	nonsynonymous SNV	ENSG00000171316.12:ENST00000423902.7:exon29:c.T5786C:p.M1929T	8q12.2	C3L-03123	.	.	.	.	.	.	.	.	.	10.20	T	T	B	B	D	D	N	D	N	0.738	T	T	D	0.453	0.227	0.897	0.889	D	T	D	T	D	D	2.537	22.500	0.902	D	D	0.005	2.528	0.190	3.136	1.000	0.707	0.725	0.725	0.655	.	5.380	5.380	4.974	1.138	0.665	1.000	1.000	1.000	810	.	.	.	.	CHD7	384	0	450	44	0.0890688259109312	TRUE	NA
ENSG00000147647.13	.	BCM	GRCh38.p13	chr8	104381266	104381266	+	C	C	T	Missense_Mutation	SNP	ENST00000351513.7	exon9	c.G1492A	p.A498T	exonic	ENSG00000147647.13	.	nonsynonymous SNV	ENSG00000147647.13:ENST00000351513.7:exon9:c.G1492A:p.A498T	8q22.3	C3L-03123	5.766e-05	0.0004	8.64e-05	0	0	0	0	0.0001	rs368932527	4.20	T	T	B	B	N	N	N	D	N	0.084	D	D	D	0.269	.	0.723	0.135	T	T	T	T	T	T	-0.333	0.266	0.786	N	N	-1.428	0.106	-1.453	0.127	0.029	0.554	0.547	0.602	0.564	.	5.850	-2.600	-1.787	-1.209	-1.150	0.000	0.027	0.183	581	.	.	.	ID=COSV60907211;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),1(prostate)	DPYS	509	0	492	70	0.124555160142349	TRUE	TRUE
ENSG00000205038.12	.	BCM	GRCh38.p13	chr8	109510903	109510903	+	G	G	A	Missense_Mutation	SNP	ENST00000378402.10	exon71	c.G11522A	p.R3841Q	exonic	ENSG00000205038.12	.	nonsynonymous SNV	ENSG00000205038.12:ENST00000378402.10:exon71:c.G11522A:p.R3841Q	8q23.2	C3L-03123	8.317e-06	0	0	0	0	1.503e-05	0	0	rs751619314	17.20	D	D	D	P	D	D	M	D	D	0.714	D	D	D	0.557	0.581	0.479	0.246	T	T	D	D	D	D	4.015	27.100	1.000	D	D	0.717	7.361	0.685	7.483	0.999	0.554	0.574	0.618	0.621	.	5.770	4.890	6.621	1.176	0.676	1.000	1.000	0.981	604	.	.	.	.	PKHD1L1	223	0	249	35	0.123239436619718	TRUE	NA
ENSG00000180938.6	.	BCM	GRCh38.p13	chr8	124976420	124976420	+	C	C	A	Missense_Mutation	SNP	ENST00000319286.6	exon3	c.C152A	p.P51H	exonic	ENSG00000180938.6	.	nonsynonymous SNV	ENSG00000180938.6:ENST00000319286.6:exon3:c.C152A:p.P51H	8q24.13	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	D	T	B	B	N	N	N	T	N	0.086	T	T	T	0.026	0.285	0.122	0.130	T	T	T	T	T	T	0.378	5.176	0.926	N	N	-1.024	0.379	-1.080	0.397	1.000	0.581	0.588	0.565	0.568	.	4.730	-1.750	-0.494	-0.708	-0.171	0.000	0.355	0.318	863	.	.	.	.	ZNF572	158	0	175	20	0.102564102564103	TRUE	TRUE
ENSG00000180921.7	.	BCM	GRCh38.p13	chr8	143728175	143728175	+	A	A	C	Missense_Mutation	SNP	ENST00000388913.4	exon5	c.T1286G	p.V429G	exonic	ENSG00000180921.7	.	nonsynonymous SNV	ENSG00000180921.7:ENST00000388913.4:exon5:c.T1286G:p.V429G	8q24.3	C3L-03123	0.0011	0.0026	0	0	0.0057	0.0011	0	0	rs201186432	5.19	D	D	B	B	N	D	L	T	D	0.205	T	T	D	0.208	.	0.249	0.442	T	T	T	T	T	.	2.088	19.920	0.963	N	N	-0.572	1.039	-0.476	1.241	0.999	0.718	0.634	0.571	0.563	.	4.960	3.780	0.513	1.159	0.714	0.108	0.967	0.053	884	.	.	.	.	FAM83H	494	1	535	79	0.128664495114007	TRUE	TRUE
ENSG00000179698.14	.	BCM	GRCh38.p13	chr8	144115434	144115434	+	G	G	A	Missense_Mutation	SNP	ENST00000323662.9	exon22	c.G4171A	p.G1391R	exonic	ENSG00000179698.14	.	nonsynonymous SNV	ENSG00000179698.14:ENST00000323662.9:exon22:c.G4171A:p.G1391R	8q24.3	C3L-03123	.	.	.	.	.	.	.	.	.	1.18	T	T	B	B	.	N	.	T	N	0.079	T	T	D	0.014	0.309	0.312	.	T	T	T	T	T	T	-0.518	0.109	0.326	N	N	-1.550	0.067	-1.683	0.055	0.999	0.581	0.547	0.578	0.605	.	1.710	-3.410	-1.303	-1.242	-1.458	0.000	0.000	0.000	970	.	.	.	.	WDR97	163	0	196	18	0.0841121495327103	TRUE	NA
ENSG00000107036.12	.	BCM	GRCh38.p13	chr9	5689960	5689960	+	C	C	T	Missense_Mutation	SNP	ENST00000414202.7	exon3	c.C254T	p.T85M	exonic	ENSG00000107036.12	.	nonsynonymous SNV	ENSG00000107036.12:ENST00000414202.7:exon3:c.C254T:p.T85M	9p24.1	C3L-03123	1.657e-05	0	0	0.0001	0	1.507e-05	0	0	rs747029814	14.20	D	D	D	P	D	D	L	T	D	0.957	D	T	D	0.478	0.547	0.235	.	T	T	D	D	D	D	4.310	29.700	0.998	D	D	0.614	6.069	0.628	6.594	1.000	0.706	0.710	0.659	0.613	.	5.310	5.310	5.459	0.934	0.599	1.000	0.962	0.979	579	.	.	.	.	RIC1	146	1	117	12	0.0930232558139535	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971106	21971106	+	C	C	T	Missense_Mutation	SNP	ENST00000304494.9	exon2	c.G253A	p.A85T	exonic	ENSG00000147889.17	.	nonsynonymous SNV	ENSG00000147889.17:ENST00000304494.9:exon2:c.G253A:p.A85T	9p21.3	C3L-03123	.	.	.	.	.	.	.	.	rs878853646	15.18	D	D	D	D	.	D	.	T	D	0.875	D	D	D	0.834	0.816	0.957	1.189	T	T	D	D	D	D	4.431	31	0.999	D	D	0.733	7.608	0.773	9.366	1.000	0.677	0.383	0.607	0.601	.	5.930	5.930	7.307	1.026	0.599	1.000	0.980	0.979	900	Ankyrin_repeat-containing_domain	.	.	ID=COSV58684450;OCCURENCE=1(large_intestine),1(central_nervous_system)	CDKN2A	1086	0	929	153	0.141404805914972	NA	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21974733	21974733	+	A	A	G	Missense_Mutation	SNP	ENST00000304494.9	exon1	c.T95C	p.L32P	exonic	ENSG00000147889.17	.	nonsynonymous SNV	ENSG00000147889.17:ENST00000304494.9:exon1:c.T95C:p.L32P	9p21.3	C3L-03123	.	.	.	.	.	.	.	.	rs878853650	15.18	D	D	D	D	.	D	.	T	D	0.858	D	D	D	0.804	0.741	0.969	1.566	T	D	D	D	D	T	4.292	29.500	0.999	D	D	0.924	11.692	0.777	9.484	1.000	0.455	0.609	0.607	0.568	.	4.890	4.890	4.468	1.312	0.756	0.998	0.407	0.906	893	Ankyrin_repeat-containing_domain	.	.	ID=COSV58685103;OCCURENCE=1(oesophagus),1(pancreas)	CDKN2A	375	0	414	69	0.142857142857143	TRUE	TRUE
ENSG00000122756.15	.	BCM	GRCh38.p13	chr9	34568939	34568939	+	C	C	T	Missense_Mutation	SNP	ENST00000378980.8	exon3	c.G43A	p.A15T	exonic	ENSG00000122756.15	.	nonsynonymous SNV	ENSG00000122756.15:ENST00000378980.8:exon3:c.G43A:p.A15T	9p13.3	C3L-03123	.	.	.	.	.	.	.	.	rs369923771	7.19	T	D	D	D	D	.	M	T	N	0.467	T	T	T	0.135	0.518	0.449	0.377	T	T	T	T	D	T	2.741	22.900	0.998	D	N	0.457	4.716	0.436	4.622	1.000	0.609	0.596	0.769	0.639	.	4.830	4.830	2.532	0.126	0.599	0.997	0.011	0.445	400	.	.	.	.	CNTFR	391	2	577	58	0.0913385826771654	TRUE	NA
ENSG00000122705.17	.	BCM	GRCh38.p13	chr9	36211757	36211757	+	G	G	A	Missense_Mutation	SNP	ENST00000433436.6	exon7	c.G730A	p.A244T	exonic	ENSG00000122705.17	.	nonsynonymous SNV	ENSG00000122705.17:ENST00000433436.6:exon7:c.G730A:p.A244T	9p13.3	C3L-03123	8.336e-06	0	0	0	0	1.51e-05	0	0	rs747907818	4.19	T	T	B	B	N	D	N	.	N	0.250	T	T	T	0.278	0.504	0.238	0.512	T	T	T	T	T	D	1.827	17.930	0.869	D	D	-0.494	1.188	-0.237	1.701	1.000	0.707	0.725	0.702	0.723	.	5.790	3.950	1.926	1.176	0.676	1.000	1.000	0.998	410	.	.	.	.	CLTA	115	0	128	19	0.129251700680272	TRUE	TRUE
ENSG00000148053.16	.	BCM	GRCh38.p13	chr9	84707867	84707867	+	C	C	T	Missense_Mutation	SNP	ENST00000323115.9	exon4	c.C383T	p.T128M	exonic	ENSG00000148053.16	.	nonsynonymous SNV	ENSG00000148053.16:ENST00000323115.9:exon4:c.C383T:p.T128M	9q21.33	C3L-03123	8.243e-06	0	0	0.0001	0	0	0	0	rs201256653	14.20	D	D	D	D	D	D	M	T	D	0.309	T	T	D	0.237	.	0.724	0.949	T	T	T	D	D	D	3.506	24.700	0.999	D	D	0.752	7.914	0.712	7.990	1.000	0.554	0.588	0.547	0.632	.	5.620	5.620	3.527	1.026	0.599	0.995	0.981	0.990	826	.	.	.	ID=COSV52867961;OCCURENCE=1(large_intestine)	NTRK2	199	0	275	28	0.0924092409240924	TRUE	TRUE
ENSG00000165025.15	.	BCM	GRCh38.p13	chr9	90844023	90844023	+	G	G	A	Missense_Mutation	SNP	ENST00000375754.9	exon2	c.G125A	p.R42H	exonic	ENSG00000165025.15	.	nonsynonymous SNV	ENSG00000165025.15:ENST00000375754.9:exon2:c.G125A:p.R42H	9q22.2	C3L-03123	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.876	D	D	D	0.961	0.936	0.969	0.802	D	D	D	D	D	D	4.400	31	1.000	D	D	1.045	15.384	0.960	16.558	1.000	0.707	0.725	0.659	0.564	.	5.160	5.160	9.382	1.164	0.662	1.000	1.000	0.992	964	SH2_domain;SYK/ZAP-70,_N-terminal_SH2_domain	.	.	ID=COSV65326552;OCCURENCE=1(oesophagus),1(prostate)	SYK	120	0	140	14	0.0909090909090909	TRUE	TRUE
ENSG00000185963.14	.	BCM	GRCh38.p13	chr9	92720721	92720721	+	C	C	T	Missense_Mutation	SNP	ENST00000375512.3	exon4	c.G641A	p.R214H	exonic	ENSG00000185963.14	.	nonsynonymous SNV	ENSG00000185963.14:ENST00000375512.3:exon4:c.G641A:p.R214H	9q22.31	C3L-03123	1.651e-05	0	0	0	0	1.502e-05	0	6.065e-05	rs373760993	14.20	T	T	D	D	D	D	M	T	D	0.731	T	T	D	0.397	.	0.712	1.665	T	D	D	D	D	D	3.549	24.900	1.000	D	D	0.748	7.854	0.720	8.146	1.000	0.722	0.699	0.725	0.714	.	5.490	5.490	6.071	1.026	0.599	1.000	0.999	0.993	976	.	.	.	ID=COSV63547819;OCCURENCE=1(large_intestine)	BICD2	315	1	306	48	0.135593220338983	TRUE	TRUE
ENSG00000197724.11	.	BCM	GRCh38.p13	chr9	93667105	93667105	+	C	C	T	Missense_Mutation	SNP	ENST00000359246.9	exon17	c.C2213T	p.S738L	exonic	ENSG00000197724.11	.	nonsynonymous SNV	ENSG00000197724.11:ENST00000359246.9:exon17:c.C2213T:p.S738L	9q22.31	C3L-03123	7.516e-05	0	0	0.0001	0	0.0001	0	0	rs763214520	3.20	T	T	B	B	N	D	L	T	N	0.154	T	T	T	0.051	0.162	0.093	0.621	T	T	T	T	T	D	1.963	18.980	0.995	D	N	-0.244	1.756	-0.091	2.071	1.000	0.732	0.744	0.723	0.728	.	4.990	4.990	4.625	1.012	0.531	1.000	0.197	0.134	958	.	.	.	.	PHF2	257	0	348	32	0.0842105263157895	TRUE	NA
ENSG00000106799.13	.	BCM	GRCh38.p13	chr9	99129073	99129073	+	T	T	C	Missense_Mutation	SNP	ENST00000374994.9	exon2	c.T316C	p.C106R	exonic	ENSG00000106799.13	.	nonsynonymous SNV	ENSG00000106799.13:ENST00000374994.9:exon2:c.T316C:p.C106R	9q22.33	C3L-03123	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.988	D	D	D	0.906	0.957	0.990	1.935	T	D	D	D	D	D	4.228	28.900	0.997	D	D	0.865	10.178	0.839	11.376	1.000	0.757	0.858	0.710	0.613	.	6.080	6.080	7.358	1.138	0.609	1.000	1.000	0.999	514	Activin_types_I_and_II_receptor_domain	.	.	.	TGFBR1	336	0	355	38	0.0966921119592875	TRUE	TRUE
ENSG00000106799.13	.	BCM	GRCh38.p13	chr9	99142568	99142568	+	T	T	C	Missense_Mutation	SNP	ENST00000374994.9	exon5	c.T838C	p.S280P	exonic	ENSG00000106799.13	.	nonsynonymous SNV	ENSG00000106799.13:ENST00000374994.9:exon5:c.T838C:p.S280P	9q22.33	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	L	D	D	0.946	D	D	D	0.951	0.746	0.977	1.854	D	T	D	D	D	D	4.269	29.300	0.999	D	D	0.825	9.299	0.821	10.791	1.000	0.732	0.744	0.744	0.613	.	5.870	5.870	8.017	1.138	0.665	1.000	1.000	0.989	480	Protein_kinase_domain	.	.	.	TGFBR1	373	0	429	43	0.0911016949152542	TRUE	TRUE
ENSG00000066697.14	.	BCM	GRCh38.p13	chr9	100442101	100442101	+	G	G	A	Missense_Mutation	SNP	ENST00000613183.1	exon2	c.G163A	p.E55K	exonic	ENSG00000066697.14	.	nonsynonymous SNV	ENSG00000066697.14:ENST00000613183.1:exon2:c.G163A:p.E55K	9q31.1	C3L-03123	.	.	.	.	.	.	.	.	.	11.18	D	D	P	P	.	D	L	.	N	0.770	T	T	T	0.237	0.664	0.189	1.232	D	D	D	D	D	D	3.623	25.100	0.999	D	D	0.458	4.725	0.513	5.278	1.000	0.745	0.634	0.710	0.762	.	5.800	5.800	6.857	1.168	0.667	1.000	0.981	0.936	312	Myb/SANT-like_DNA-binding_domain	.	.	ID=COSV58492424;OCCURENCE=1(breast)	MSANTD3	361	1	446	58	0.115079365079365	TRUE	TRUE
ENSG00000148356.13	.	BCM	GRCh38.p13	chr9	127479500	127479500	+	A	A	G	Missense_Mutation	SNP	ENST00000323301.8	exon12	c.A898G	p.K300E	exonic	ENSG00000148356.13	.	nonsynonymous SNV	ENSG00000148356.13:ENST00000323301.8:exon12:c.A898G:p.K300E	9q33.3	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	D	T	B	B	N	D	L	T	N	0.476	T	T	T	0.078	0.211	0.566	0.262	T	T	T	T	D	D	3.007	23.400	0.995	D	N	-0.187	1.913	-0.058	2.172	0.868	0.707	0.725	0.725	0.714	.	5.740	4.570	3.594	1.312	0.756	1.000	0.996	0.907	513	.	.	.	.	LRSAM1	411	0	478	35	0.0682261208576998	TRUE	TRUE
ENSG00000136802.11	.	BCM	GRCh38.p13	chr9	128907616	128907616	+	C	C	T	Missense_Mutation	SNP	ENST00000259324.5	exon3	c.C452T	p.S151L	exonic	ENSG00000136802.11	.	nonsynonymous SNV	ENSG00000136802.11:ENST00000259324.5:exon3:c.C452T:p.S151L	9q34.11	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.895	T	T	D	0.392	0.274	0.413	1.903	D	T	D	D	D	D	3.983	26.900	0.999	D	D	0.783	8.462	0.765	9.160	1.000	0.707	0.577	0.725	0.711	.	5.170	5.170	7.905	1.026	0.599	1.000	0.987	0.992	901	LRRC8,_pannexin-like_TM_region	.	.	.	LRRC8A	347	0	430	49	0.102296450939457	TRUE	TRUE
ENSG00000107147.13	.	BCM	GRCh38.p13	chr9	135786344	135786344	+	A	A	C	Missense_Mutation	SNP	ENST00000488444.6	exon28	c.A3247C	p.S1083R	exonic	ENSG00000107147.13	.	nonsynonymous SNV	ENSG00000107147.13:ENST00000488444.6:exon28:c.A3247C:p.S1083R	9q34.3	C3L-03123	.	.	.	.	.	.	.	.	.	10.18	D	D	.	.	U	D	M	T	N	0.810	T	T	D	0.315	-	0.599	0.409	T	T	D	T	D	D	3.902	26.400	0.997	D	D	0.566	5.591	0.485	5.022	1.000	0.649	0.547	0.596	0.563	.	4.750	4.750	8.557	1.202	0.683	1.000	0.984	0.740	536	.	.	.	.	KCNT1	622	1	684	82	0.107049608355091	TRUE	TRUE
ENSG00000159069.14	.	BCM	GRCh38.p13	chr9	136942070	136942070	+	G	G	T	Missense_Mutation	SNP	ENST00000325285.8	exon6	c.C1072A	p.L358I	exonic	ENSG00000159069.14	.	nonsynonymous SNV	ENSG00000159069.14:ENST00000325285.8:exon6:c.C1072A:p.L358I	9q34.3	C3L-03123	.	.	.	.	.	.	.	.	.	9.20	T	T	D	P	D	D	M	T	N	0.448	T	T	D	0.133	0.274	0.807	.	T	T	T	T	D	D	3.004	23.400	0.993	D	D	0.355	4.077	0.357	4.069	1.000	0.672	0.698	0.702	0.711	.	4.590	3.690	6.228	1.082	0.567	1.000	1.000	0.996	878	.	.	.	.	FBXW5	158	0	229	23	0.0912698412698413	TRUE	TRUE
ENSG00000198113.3	.	BCM	GRCh38.p13	chr9	137279281	137279281	+	G	G	A	Missense_Mutation	SNP	ENST00000357503.3	exon2	c.G592A	p.V198M	exonic	ENSG00000198113.3	.	nonsynonymous SNV	ENSG00000198113.3:ENST00000357503.3:exon2:c.G592A:p.V198M	9q34.3	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	H	T	N	0.593	T	T	D	0.424	0.706	0.313	2.400	D	T	D	T	D	D	4.075	27.500	0.999	D	D	0.832	9.446	0.790	9.839	1.000	0.722	0.699	0.654	0.639	.	5.140	5.140	2.988	1.085	0.570	0.999	0.997	0.994	988	AAA+_ATPase_domain	.	.	.	TOR4A	320	0	359	34	0.0865139949109415	TRUE	TRUE
ENSG00000134461.16	.	BCM	GRCh38.p13	chr10	5883052	5883052	+	A	A	G	Missense_Mutation	SNP	ENST00000380094.10	exon5	c.T803C	p.V268A	exonic	ENSG00000134461.16	.	nonsynonymous SNV	ENSG00000134461.16:ENST00000380094.10:exon5:c.T803C:p.V268A	10p15.1	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.108	T	T	T	0.015	0.379	0.120	0.225	T	T	T	T	T	T	0.770	9.096	0.322	N	N	-1.407	0.114	-1.394	0.154	0.745	0.707	0.725	0.725	0.636	.	5.330	-1.960	0.215	-0.051	-0.050	0.084	0.000	0.004	819	Ankyrin_repeat-containing_domain	.	.	.	ANKRD16	240	0	264	36	0.12	TRUE	TRUE
ENSG00000177354.12	.	BCM	GRCh38.p13	chr10	49326491	49326491	+	G	G	A	Missense_Mutation	SNP	ENST00000374144.8	exon3	c.G3946A	p.E1316K	exonic	ENSG00000177354.12	.	nonsynonymous SNV	ENSG00000177354.12:ENST00000374144.8:exon3:c.G3946A:p.E1316K	10q11.23	C3L-03123	.	.	.	.	.	.	.	.	.	4.15	D	D	.	.	U	N	.	T	N	0.109	T	T	D	0.088	0.166	0.286	0.297	.	.	T	T	T	T	2.765	23.000	0.997	D	N	-0.048	2.344	-0.073	2.126	0.800	0.487	0.590	0.547	0.564	.	5.650	4.750	1.793	0.230	-0.194	0.979	0.045	0.410	894	.	.	.	ID=COSV60506011;OCCURENCE=1(cervix)	C10orf71	253	0	293	41	0.122754491017964	TRUE	TRUE
ENSG00000171988.19	.	BCM	GRCh38.p13	chr10	63264682	63264682	+	A	A	T	Nonsense_Mutation	SNP	ENST00000399262.7	exon3	c.T416A	p.L139X	exonic	ENSG00000171988.19	.	stopgain	ENSG00000171988.19:ENST00000399262.7:exon3:c.T416A:p.L139X	10q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	U	D	.	.	.	0.742	.	.	.	.	.	.	.	.	.	D	D	.	.	6.866	36	0.989	D	N	0.858	10.014	0.747	8.733	1.000	0.660	0.587	0.663	0.658	.	5.620	5.620	4.294	1.298	0.674	1.000	1.000	0.997	595	.	.	.	.	JMJD1C	158	0	168	23	0.120418848167539	TRUE	TRUE
ENSG00000138336.9	.	BCM	GRCh38.p13	chr10	68691516	68691516	+	G	G	A	Missense_Mutation	SNP	ENST00000373644.5	exon12	c.G6113A	p.R2038H	exonic	ENSG00000138336.9	.	nonsynonymous SNV	ENSG00000138336.9:ENST00000373644.5:exon12:c.G6113A:p.R2038H	10q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.725	T	T	T	0.498	0.436	0.151	1.134	T	T	D	D	D	D	4.405	31	1.000	D	D	0.830	9.404	0.770	9.293	1.000	0.672	0.588	0.702	0.568	.	5.600	5.600	9.559	1.176	0.676	1.000	0.201	0.987	792	2OGFeDO,_oxygenase_domain	.	.	ID=COSV65383302;OCCURENCE=1(stomach)	TET1	319	0	408	26	0.0599078341013825	TRUE	TRUE
ENSG00000189129.14	.	BCM	GRCh38.p13	chr10	80142148	80142148	+	C	C	T	Missense_Mutation	SNP	ENST00000372263.4	exon2	c.C131T	p.A44V	exonic	ENSG00000189129.14	.	nonsynonymous SNV	ENSG00000189129.14:ENST00000372263.4:exon2:c.C131T:p.A44V	10q22.3	C3L-03123	.	.	.	.	.	.	.	.	.	9.18	D	D	D	D	N	N	.	.	D	0.691	T	T	T	0.241	0.199	0.105	0.042	T	T	D	D	D	T	3.557	24.900	0.996	D	N	0.295	3.753	0.182	3.095	1.000	0.706	0.590	0.710	0.646	.	3.740	3.740	2.722	0.985	0.530	0.958	0.052	0.038	919	.	.	.	.	PLAC9	105	0	118	9	0.0708661417322835	TRUE	TRUE
ENSG00000182771.19	.	BCM	GRCh38.p13	chr10	85724627	85724627	+	C	C	T	Missense_Mutation	SNP	ENST00000327946.12	exon11	c.G1583A	p.S528N	exonic	ENSG00000182771.19	.	nonsynonymous SNV	ENSG00000182771.19:ENST00000327946.12:exon11:c.G1583A:p.S528N	10q23.1	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	N	T	N	0.129	T	T	T	0.127	0.292	0.123	0.213	T	T	T	T	T	T	1.185	13.510	0.362	D	N	-0.587	1.011	-0.335	1.494	0.000	0.534	0.611	0.616	0.564	.	5.830	4.930	1.286	0.127	-0.193	0.968	0.998	0.974	931	Ionotropic_glutamate_receptor,_L-glutamate_and_glycine-binding_domain;Ionotropic_glutamate_receptor	.	.	ID=COSV60052579;OCCURENCE=1(large_intestine)	GRID1	208	0	209	21	0.091304347826087	TRUE	TRUE
ENSG00000119922.10	.	BCM	GRCh38.p13	chr10	89306911	89306911	+	G	G	A	Missense_Mutation	SNP	ENST00000371826.4	exon2	c.G955A	p.A319T	exonic	ENSG00000119922.10	.	nonsynonymous SNV	ENSG00000119922.10:ENST00000371826.4:exon2:c.G955A:p.A319T	10q23.31	C3L-03123	1.659e-05	0.0001	0	0	0	1.501e-05	0	0	rs775027680	3.20	D	T	P	B	U	N	N	T	D	0.496	T	T	D	0.318	0.776	0.737	0.652	T	T	T	T	T	T	2.288	21.500	0.999	N	N	-0.213	1.841	-0.305	1.553	1.000	0.563	0.654	0.547	0.616	.	4.580	3.670	0.451	1.176	0.676	0.000	0.535	0.855	818	.	.	.	ID=COSV99260146;OCCURENCE=1(large_intestine),1(endometrium)	IFIT2	392	0	426	47	0.0993657505285412	TRUE	TRUE
ENSG00000155287.11	.	BCM	GRCh38.p13	chr10	99620121	99620121	+	A	A	G	Missense_Mutation	SNP	ENST00000370495.6	exon1	c.T215C	p.V72A	exonic	ENSG00000155287.11	.	nonsynonymous SNV	ENSG00000155287.11:ENST00000370495.6:exon1:c.T215C:p.V72A	10q24.2	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	L	T	N	0.301	T	T	D	0.299	0.723	0.390	1.539	D	T	T	T	D	T	3.506	24.700	0.987	D	N	-0.029	2.411	0.097	2.723	1.000	0.652	0.522	0.641	0.581	.	4.490	4.490	4.154	1.214	0.639	1.000	1.000	0.996	821	.	.	.	.	SLC25A28	228	0	297	27	0.0833333333333333	TRUE	TRUE
ENSG00000107816.17	.	BCM	GRCh38.p13	chr10	101007032	101007032	+	A	A	G	Missense_Mutation	SNP	ENST00000370220.1	exon4	c.A1874G	p.Y625C	exonic	ENSG00000107816.17	.	nonsynonymous SNV	ENSG00000107816.17:ENST00000370220.1:exon4:c.A1874G:p.Y625C	10q24.31	C3L-03123	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	N	D	M	T	D	0.310	T	T	D	0.241	0.790	0.223	0.353	T	T	T	T	D	T	3.083	23.600	0.982	D	D	-0.230	1.794	-0.114	2.007	1.000	0.732	0.744	0.607	0.714	.	5.100	1.200	4.229	1.228	0.658	1.000	1.000	0.999	554	.	.	.	.	LZTS2	297	0	362	25	0.0645994832041344	TRUE	TRUE
ENSG00000187164.20	.	BCM	GRCh38.p13	chr10	116906662	116906662	+	C	C	T	Missense_Mutation	SNP	ENST00000355371.9	exon15	c.G1445A	p.R482H	exonic	ENSG00000187164.20	.	nonsynonymous SNV	ENSG00000187164.20:ENST00000355371.9:exon15:c.G1445A:p.R482H	10q25.3	C3L-03123	5.838e-05	0.0001	0.0004	0	0	1.513e-05	0	0	rs764643872	9.19	D	D	D	D	N	D	L	.	N	0.680	T	T	T	0.191	.	0.313	1.394	T	T	T	D	T	D	3.966	26.700	0.999	D	D	0.693	7.028	0.693	7.628	1.000	0.706	0.574	0.710	0.714	.	5.490	5.490	5.432	1.026	0.599	1.000	1.000	0.998	603	.	.	.	ID=COSV104592860;OCCURENCE=1(skin)	SHTN1	189	0	262	27	0.0934256055363322	TRUE	NA
ENSG00000154485.5	.	BCM	GRCh38.p13	chr10	125772245	125772245	+	C	C	T	Missense_Mutation	SNP	ENST00000368808.3	exon4	c.G952A	p.D318N	exonic	ENSG00000154485.5	.	nonsynonymous SNV	ENSG00000154485.5:ENST00000368808.3:exon4:c.G952A:p.D318N	10q26.2	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	H	T	D	0.910	D	D	D	0.597	0.924	0.954	0.818	T	T	T	T	D	D	3.237	24.000	0.999	D	D	0.883	10.630	0.737	8.500	1.000	0.517	0.514	0.479	0.568	.	5.190	5.190	5.053	1.026	0.599	1.000	0.984	0.204	940	Peptidase,_metallopeptidase;Peptidase_M10A,_catalytic_domain;Peptidase_M10,_metallopeptidase	.	.	.	MMP21	267	0	303	39	0.114035087719298	TRUE	TRUE
ENSG00000177595.18	.	BCM	GRCh38.p13	chr11	799384	799384	+	G	G	A	Missense_Mutation	SNP	ENST00000347755.10	exon16	c.C2656T	p.R886C	exonic	ENSG00000177595.18	.	nonsynonymous SNV	ENSG00000177595.18:ENST00000347755.10:exon16:c.C2656T:p.R886C	11p15.5	C3L-03123	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	N	M	D	D	0.646	D	D	D	0.379	0.301	0.877	0.299	T	D	D	D	D	D	3.639	25.200	0.998	D	N	0.143	3.059	0.040	2.500	1.000	0.672	0.644	0.644	0.711	.	5.040	5.040	2.841	1.087	0.574	0.827	0.057	0.005	884	.	.	.	.	PIDD1	247	0	360	32	0.0816326530612245	TRUE	TRUE
ENSG00000110713.17	.	BCM	GRCh38.p13	chr11	3691464	3691464	+	G	G	T	Missense_Mutation	SNP	ENST00000359171.8	exon28	c.C4388A	p.A1463D	exonic	ENSG00000110713.17	.	nonsynonymous SNV	ENSG00000110713.17:ENST00000359171.8:exon28:c.C4388A:p.A1463D	11p15.4	C3L-03123	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	M	.	D	0.939	T	T	D	0.492	0.344	0.571	0.933	T	T	D	D	D	D	3.972	26.800	0.998	D	D	0.485	4.922	0.502	5.182	1.000	0.707	0.725	0.725	0.714	.	5.570	5.570	9.606	1.071	0.604	1.000	0.990	0.182	534	Nuclear_protein_96	.	.	.	NUP98	367	0	376	49	0.115294117647059	TRUE	TRUE
ENSG00000197790.1	.	BCM	GRCh38.p13	chr11	4546083	4546083	+	G	G	A	Missense_Mutation	SNP	ENST00000360213.1	exon1	c.G893A	p.R298H	exonic	ENSG00000197790.1	.	nonsynonymous SNV	ENSG00000197790.1:ENST00000360213.1:exon1:c.G893A:p.R298H	11p15.4	C3L-03123	0.0012	0.0124	0.0009	0	0	0.0001	0.0022	0	rs78242421	5.19	D	D	B	B	D	N	H	T	D	0.312	T	T	.	0.119	.	0.598	.	T	T	T	T	T	T	1.221	13.800	0.991	N	N	-0.273	1.682	-0.391	1.388	0.003	0.487	0.574	0.574	0.542	.	4.910	3.030	0.531	-0.140	-0.682	0.000	0.015	0.017	800	.	.	.	ID=COSV99081024;OCCURENCE=2(lung)	OR52M1	140	0	195	17	0.080188679245283	TRUE	NA
ENSG00000179532.13	.	BCM	GRCh38.p13	chr11	6545497	6545497	+	C	C	T	Missense_Mutation	SNP	ENST00000254579.11	exon21	c.C4558T	p.R1520W	exonic	ENSG00000179532.13	.	nonsynonymous SNV	ENSG00000179532.13:ENST00000254579.11:exon21:c.C4558T:p.R1520W	11p15.4	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.251	T	T	T	0.066	0.733	0.145	0.124	T	T	T	T	T	T	1.657	16.740	0.991	N	N	-0.553	1.075	-0.466	1.258	0.683	0.615	0.577	0.616	0.528	.	5.660	-0.134	-0.444	0.123	0.599	0.551	0.998	0.991	470	.	.	.	.	DNHD1	420	0	418	29	0.0648769574944072	TRUE	NA
ENSG00000179057.13	.	BCM	GRCh38.p13	chr11	18716970	18716970	+	T	T	C	Missense_Mutation	SNP	ENST00000513874.5	exon10	c.A1004G	p.K335R	exonic	ENSG00000179057.13	.	nonsynonymous SNV	ENSG00000179057.13:ENST00000513874.5:exon10:c.A1004G:p.K335R	11p15.1	C3L-03123	.	.	.	.	.	.	.	.	.	3.16	T	D	.	.	U	N	.	T	N	0.204	T	T	T	0.227	0.523	0.871	0.419	T	.	T	T	D	T	2.709	22.800	0.999	D	N	0.316	3.864	0.292	3.672	0.004	0.447	0.563	0.563	0.530	.	5.030	3.860	2.046	1.138	0.665	0.980	0.684	0.964	786	.	.	.	.	IGSF22	188	0	217	19	0.0805084745762712	TRUE	TRUE
ENSG00000109920.13	.	BCM	GRCh38.p13	chr11	47722991	47722991	+	T	T	-	Frame_Shift_Del	DEL	ENST00000263773.10	exon15	c.2790delA	p.G931Efs*17	exonic	ENSG00000109920.13	.	frameshift deletion	ENSG00000109920.13:ENST00000263773.10:exon15:c.2790delA:p.G931Efs*17	11p11.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FNBP4	125	1	161	20	0.110497237569061	TRUE	TRUE
ENSG00000198561.15	.	BCM	GRCh38.p13	chr11	57796575	57796575	+	G	G	A	Missense_Mutation	SNP	ENST00000399050.10	exon6	c.G539A	p.R180H	exonic	ENSG00000198561.15	.	nonsynonymous SNV	ENSG00000198561.15:ENST00000399050.10:exon6:c.G539A:p.R180H	11q12.1	C3L-03123	1.656e-05	0	0	0.0001	0	1.499e-05	0	0	rs771907778	17.20	D	D	D	D	D	D	M	T	D	0.836	D	D	D	0.529	0.597	0.840	1.228	T	T	D	D	D	D	4.220	28.900	1.000	D	D	0.851	9.866	0.866	12.378	1.000	0.707	0.725	0.702	0.714	.	6.010	6.010	6.501	1.176	0.676	1.000	1.000	0.999	378	.	.	.	.	CTNND1	215	0	225	14	0.0585774058577406	TRUE	NA
ENSG00000124942.14	.	BCM	GRCh38.p13	chr11	62524384	62524384	+	C	C	A	Missense_Mutation	SNP	ENST00000378024.9	exon5	c.G10033T	p.G3345C	exonic	ENSG00000124942.14	.	nonsynonymous SNV	ENSG00000124942.14:ENST00000378024.9:exon5:c.G10033T:p.G3345C	11q12.3	C3L-03123	.	.	.	.	.	.	.	.	.	9.18	D	D	D	D	.	D	M	T	D	0.408	T	T	T	0.139	0.256	0.140	0.206	T	D	T	T	D	T	3.103	23.600	0.993	N	.	0.306	3.811	0.060	2.576	0.345	0.706	0.710	0.659	0.714	.	4.050	1.960	0.573	0.128	0.549	0.002	0.841	0.989	244	.	.	.	.	AHNAK	182	0	245	19	0.071969696969697	TRUE	TRUE
ENSG00000149823.9	.	BCM	GRCh38.p13	chr11	65108580	65108580	+	G	G	A	Missense_Mutation	SNP	ENST00000279281.8	exon5	c.G1109A	p.R370Q	exonic	ENSG00000149823.9	.	nonsynonymous SNV	ENSG00000149823.9:ENST00000279281.8:exon5:c.G1109A:p.R370Q	11q13.1	C3L-03123	.	.	.	.	.	.	.	.	.	12.19	D	T	P	B	D	D	M	.	D	0.730	T	T	T	0.658	0.738	0.459	1.804	D	T	D	D	D	D	3.713	25.500	0.999	D	D	0.516	5.165	0.569	5.851	1.000	0.672	0.702	0.723	0.636	.	5.190	4.220	9.745	1.083	0.574	1.000	1.000	0.994	373	.	.	.	.	VPS51	679	0	707	79	0.100508905852417	TRUE	TRUE
ENSG00000197136.4	.	BCM	GRCh38.p13	chr11	65623610	65623610	+	T	T	C	Missense_Mutation	SNP	ENST00000355703.3	exon12	c.T2477C	p.L826P	exonic	ENSG00000197136.4	.	nonsynonymous SNV	ENSG00000197136.4:ENST00000355703.3:exon12:c.T2477C:p.L826P	11q13.1	C3L-03123	.	.	.	.	.	.	.	.	.	15.19	D	D	D	P	.	D	M	T	D	0.934	D	T	D	0.793	0.564	0.970	.	D	T	D	D	D	D	4.141	28.100	0.999	D	D	0.596	5.881	0.551	5.664	1.000	0.732	0.702	0.744	0.714	.	4.310	4.310	7.920	1.104	0.625	1.000	0.994	0.994	275	.	.	.	.	PCNX3	296	0	333	28	0.0775623268698061	TRUE	TRUE
ENSG00000175463.12	.	BCM	GRCh38.p13	chr11	67405982	67405982	+	G	G	A	Missense_Mutation	SNP	ENST00000542590.2	exon5	c.G547A	p.V183M	exonic	ENSG00000175463.12	.	nonsynonymous SNV	ENSG00000175463.12:ENST00000542590.2:exon5:c.G547A:p.V183M	11q13.2	C3L-03123	1.432e-05	0	0.0002	0	0	0	0	0	rs778177831	9.19	D	D	D	D	D	D	.	T	N	0.640	T	T	T	0.222	0.714	0.326	.	T	T	T	T	D	D	3.928	26.500	0.999	D	N	0.529	5.271	0.467	4.869	1.000	0.628	0.672	0.578	0.605	.	4.340	4.340	2.011	1.176	0.676	0.990	0.680	0.661	514	Rab-GTPase-TBC_domain	.	.	.	TBC1D10C	222	0	252	44	0.148648648648649	TRUE	NA
ENSG00000149300.10	.	BCM	GRCh38.p13	chr11	111926036	111926036	+	T	T	C	Missense_Mutation	SNP	ENST00000278601.6	exon4	c.T209C	p.M70T	exonic	ENSG00000149300.10	.	nonsynonymous SNV	ENSG00000149300.10:ENST00000278601.6:exon4:c.T209C:p.M70T	11q23.1	C3L-03123	8.242e-06	0	0	0.0001	0	0	0	0	rs587644032	0.19	T	T	B	B	N	N	N	T	N	0.054	T	T	T	0.085	.	0.107	0.614	.	T	T	T	T	T	-0.936	0.011	0.277	N	N	-1.924	0.013	-1.985	0.015	1.000	0.539	0.624	0.784	0.550	.	4.720	-8.720	-1.469	-3.140	-1.794	0.000	0.000	0.000	90	.	.	.	.	C11orf52	589	1	624	40	0.0602409638554217	TRUE	NA
ENSG00000110063.10	.	BCM	GRCh38.p13	chr11	126345369	126345369	+	G	G	A	Missense_Mutation	SNP	ENST00000263579.5	exon6	c.G770A	p.R257Q	exonic	ENSG00000110063.10	.	nonsynonymous SNV	ENSG00000110063.10:ENST00000263579.5:exon6:c.G770A:p.R257Q	11q24.2	C3L-03123	1.654e-05	0	0	0.0001	0	0	0	6.064e-05	rs747057647	1.20	T	T	B	B	N	N	N	D	N	0.131	T	T	T	0.281	.	0.508	0.132	T	T	T	T	T	T	1.165	13.360	0.679	N	N	-1.586	0.058	-1.439	0.133	1.000	0.722	0.702	0.699	0.711	.	5.300	-2.920	2.718	-0.084	-0.773	1.000	0.563	0.072	933	.	.	.	.	DCPS	336	0	365	28	0.0712468193384224	TRUE	NA
ENSG00000149571.12	.	BCM	GRCh38.p13	chr11	126521384	126521384	+	C	C	T	Missense_Mutation	SNP	ENST00000525144.7	exon4	c.G364A	p.D122N	exonic	ENSG00000149571.12	.	nonsynonymous SNV	ENSG00000149571.12:ENST00000525144.7:exon4:c.G364A:p.D122N	11q24.2	C3L-03123	4.265e-05	0	0.0016	0	0	0	0	0	rs767674597	13.20	D	D	D	D	D	D	M	T	D	0.543	T	T	D	0.366	0.341	0.613	1.262	T	T	T	T	D	D	3.605	25.100	0.999	D	D	0.746	7.821	0.650	6.907	1.000	0.554	0.563	0.602	0.564	.	4.650	4.650	7.867	1.026	0.599	1.000	0.036	0.085	954	Immunoglobulin_subtype_2;Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV73104760;OCCURENCE=3(oesophagus)	KIRREL3	154	0	187	14	0.0696517412935323	TRUE	TRUE
ENSG00000149418.11	.	BCM	GRCh38.p13	chr11	130189885	130189885	+	T	T	C	Missense_Mutation	SNP	ENST00000278742.6	exon5	c.T587C	p.V196A	exonic	ENSG00000149418.11	.	nonsynonymous SNV	ENSG00000149418.11:ENST00000278742.6:exon5:c.T587C:p.V196A	11q24.3	C3L-03123	.	.	.	.	.	.	.	.	.	10.20	T	D	P	P	N	D	M	D	N	0.533	D	D	D	0.444	0.328	0.894	0.966	T	T	T	T	D	T	3.582	25.000	0.998	D	D	0.413	4.427	0.414	4.457	1.000	0.632	0.634	0.780	0.542	.	4.980	4.980	2.952	1.138	0.665	0.955	0.986	0.639	729	SEA_domain	.	.	.	ST14	409	0	427	47	0.0991561181434599	TRUE	TRUE
ENSG00000183715.13	.	BCM	GRCh38.p13	chr11	132437248	132437248	+	A	A	G	Missense_Mutation	SNP	ENST00000331898.11	exon4	c.T638C	p.V213A	exonic	ENSG00000183715.13	.	nonsynonymous SNV	ENSG00000183715.13:ENST00000331898.11:exon4:c.T638C:p.V213A	11q25	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	D	T	P	P	D	D	N	T	N	0.581	T	T	T	0.094	0.463	0.385	1.597	T	T	T	T	D	T	3.626	25.100	0.998	D	D	0.432	4.547	0.520	5.343	1.000	0.554	0.590	0.602	0.564	.	5.950	5.950	5.900	1.312	0.756	1.000	0.727	0.811	938	Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	OPCML	190	0	183	21	0.102941176470588	TRUE	TRUE
ENSG00000139044.12	.	BCM	GRCh38.p13	chr12	460413	460413	+	C	C	A	Missense_Mutation	SNP	ENST00000266383.10	exon1	c.C37A	p.L13M	exonic	ENSG00000139044.12	.	nonsynonymous SNV	ENSG00000139044.12:ENST00000266383.10:exon1:c.C37A:p.L13M	12p13.33	C3L-03123	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	U	N	L	T	N	0.308	T	T	D	0.084	0.345	0.190	0.140	D	T	T	T	T	T	1.141	13.150	0.836	N	N	-0.490	1.196	-0.577	1.081	1.000	0.455	0.492	0.607	0.555	.	3.870	-2.510	-0.258	0.815	0.417	0.000	0.789	0.146	461	.	.	.	.	B4GALNT3	233	1	314	84	0.21105527638191	TRUE	NA
ENSG00000111262.6	.	BCM	GRCh38.p13	chr12	4911922	4911922	+	G	G	A	Missense_Mutation	SNP	ENST00000382545.5	exon2	c.G544A	p.V182I	exonic	ENSG00000111262.6	.	nonsynonymous SNV	ENSG00000111262.6:ENST00000382545.5:exon2:c.G544A:p.V182I	12p13.32	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	L	T	N	0.367	T	T	T	0.134	0.434	0.733	2.081	D	D	T	T	D	D	2.550	22.500	0.986	D	D	0.032	2.626	0.205	3.209	1.000	0.765	0.541	0.732	0.530	.	4.710	4.710	8.123	1.176	0.676	1.000	0.998	0.997	855	Ion_transport_domain	.	.	ID=COSV66838528;OCCURENCE=1(large_intestine),1(lung)	KCNA1	225	0	280	24	0.0789473684210526	TRUE	TRUE
ENSG00000110799.13	.	BCM	GRCh38.p13	chr12	6075367	6075367	+	A	A	G	Missense_Mutation	SNP	ENST00000261405.9	exon7	c.T842C	p.V281A	exonic	ENSG00000110799.13	.	nonsynonymous SNV	ENSG00000110799.13:ENST00000261405.9:exon7:c.T842C:p.V281A	12p13.31	C3L-03123	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	N	0.333	T	T	D	0.172	0.561	0.506	0.381	T	T	T	T	D	T	1.361	14.810	0.758	N	N	-0.671	0.862	-0.718	0.874	1.000	0.731	0.596	0.769	0.649	.	4.840	1.060	2.240	1.312	0.756	0.362	0.066	0.016	917	Uncharacterised_domain,_cysteine-rich	.	.	.	VWF	506	0	670	64	0.0871934604904632	TRUE	TRUE
ENSG00000111676.15	.	BCM	GRCh38.p13	chr12	6938860	6938860	+	C	C	T	Missense_Mutation	SNP	ENST00000396684.3	exon7	c.C2897T	p.P966L	exonic	ENSG00000111676.15	.	nonsynonymous SNV	ENSG00000111676.15:ENST00000396684.3:exon7:c.C2897T:p.P966L	12p13.31	C3L-03123	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	U	D	L	T	D	0.336	T	T	D	0.228	.	0.422	2.054	T	D	T	T	D	T	2.926	23.300	0.999	D	N	0.384	4.246	0.390	4.290	1.000	0.722	0.699	0.696	0.711	.	4.910	4.910	0.397	1.026	-0.173	0.014	0.995	0.219	754	.	.	.	.	ATN1	413	0	535	108	0.16796267496112	TRUE	NA
ENSG00000139178.11	.	BCM	GRCh38.p13	chr12	7101969	7101969	+	C	C	T	Missense_Mutation	SNP	ENST00000266542.9	exon3	c.G419A	p.R140H	exonic	ENSG00000139178.11	.	nonsynonymous SNV	ENSG00000139178.11:ENST00000266542.9:exon3:c.G419A:p.R140H	12p13.31	C3L-03123	0.0002	0	0.0023	0.0001	0	1.5e-05	0	0	rs201847594	2.20	T	T	D	D	N	N	L	T	N	0.049	T	T	T	0.055	.	0.061	0.224	T	T	T	T	T	T	-0.184	0.553	0.967	N	N	-1.074	0.330	-1.261	0.236	1.000	0.719	0.634	0.723	0.714	.	3.760	-4.020	-1.326	-0.732	-0.202	0.000	0.003	0.149	637	CUB_domain	.	.	ID=COSV56926292;OCCURENCE=1(large_intestine)	C1RL	324	0	385	37	0.0876777251184834	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-03123	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	411	0	459	217	0.321005917159763	TRUE	TRUE
ENSG00000064102.15	.	BCM	GRCh38.p13	chr12	26928772	26928772	+	G	G	A	Missense_Mutation	SNP	ENST00000261191.12	exon4	c.C434T	p.T145I	exonic	ENSG00000064102.15	.	nonsynonymous SNV	ENSG00000064102.15:ENST00000261191.12:exon4:c.C434T:p.T145I	12p11.23	C3L-03123	.	.	.	.	.	.	.	.	.	8.19	T	D	P	P	D	D	.	T	D	0.246	T	T	T	0.227	0.518	0.043	0.783	T	T	T	T	D	D	3.252	24.000	0.997	D	D	0.556	5.503	0.604	6.280	1.000	0.707	0.725	0.725	0.714	.	5.370	5.370	6.288	1.157	0.595	1.000	1.000	0.999	827	.	.	.	.	INTS13	456	0	554	52	0.0858085808580858	TRUE	NA
ENSG00000177875.5	.	BCM	GRCh38.p13	chr12	48184565	48184565	+	C	C	A	Missense_Mutation	SNP	ENST00000316554.5	exon1	c.C443A	p.P148H	exonic	ENSG00000177875.5	.	nonsynonymous SNV	ENSG00000177875.5:ENST00000316554.5:exon1:c.C443A:p.P148H	12q13.11	C3L-03123	.	.	.	.	.	.	.	.	.	5.19	D	D	P	P	N	N	N	T	D	0.421	T	T	T	0.157	0.142	0.159	0.799	.	T	T	T	D	T	3.804	25.900	0.940	D	N	0.240	3.484	0.295	3.689	1.000	0.598	0.563	0.504	0.639	.	5.110	5.110	1.630	1.026	0.599	0.845	0.357	0.986	739	.	.	.	ID=COSV100344059;OCCURENCE=1(stomach)	CCDC184	161	0	204	13	0.0599078341013825	TRUE	TRUE
ENSG00000187166.1	.	BCM	GRCh38.p13	chr12	48329587	48329587	+	C	C	T	Missense_Mutation	SNP	ENST00000335017.1	exon1	c.C296T	p.A99V	exonic	ENSG00000187166.1	.	nonsynonymous SNV	ENSG00000187166.1:ENST00000335017.1:exon1:c.C296T:p.A99V	12q13.11	C3L-03123	4.634e-05	0	0	0	0.0005	3.39e-05	0	0	rs775913130	2.19	D	D	P	B	.	N	L	T	N	0.093	T	T	T	0.049	0.280	0.202	0.632	T	T	T	T	T	T	0.606	7.568	0.997	N	N	-0.692	0.827	-0.798	0.761	0.000	0.487	0.574	0.547	0.542	.	4.900	0.701	0.268	-0.844	0.599	0.000	0.000	0.002	582	.	.	.	.	H1-7	481	0	499	142	0.221528861154446	TRUE	NA
ENSG00000181418.8	.	BCM	GRCh38.p13	chr12	48997263	48997263	+	T	T	C	Missense_Mutation	SNP	ENST00000421952.3	exon2	c.A1613G	p.D538G	exonic	ENSG00000181418.8	.	nonsynonymous SNV	ENSG00000181418.8:ENST00000421952.3:exon2:c.A1613G:p.D538G	12q13.12	C3L-03123	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	N	L	T	D	0.220	T	T	D	0.127	0.173	0.303	1.475	T	T	T	T	D	T	2.218	21.000	0.993	N	N	-0.630	0.934	-0.734	0.852	1.000	0.564	0.552	0.608	0.619	.	3.680	2.490	0.100	1.066	0.519	0.004	0.025	0.031	612	.	.	.	.	DDN	136	0	129	38	0.227544910179641	TRUE	TRUE
ENSG00000011465.17	.	BCM	GRCh38.p13	chr12	91153099	91153099	+	G	G	C	Missense_Mutation	SNP	ENST00000052754.10	exon6	c.C743G	p.A248G	exonic	ENSG00000011465.17	.	nonsynonymous SNV	ENSG00000011465.17:ENST00000052754.10:exon6:c.C743G:p.A248G	12q21.33	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	N	T	N	0.458	T	T	T	0.108	0.381	0.597	0.277	T	T	T	T	D	D	4.447	32	0.986	D	D	0.065	2.751	0.267	3.532	1.000	0.554	0.574	0.618	0.564	.	5.450	5.450	9.806	1.176	0.618	1.000	0.999	0.895	893	.	.	.	.	DCN	345	1	315	80	0.20253164556962	TRUE	TRUE
ENSG00000110906.13	.	BCM	GRCh38.p13	chr12	109456258	109456258	+	G	G	A	Missense_Mutation	SNP	ENST00000228495.11	exon6	c.C583T	p.R195C	exonic	ENSG00000110906.13	.	nonsynonymous SNV	ENSG00000110906.13:ENST00000228495.11:exon6:c.C583T:p.R195C	12q24.11	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	D	P	D	D	M	T	D	0.768	T	T	D	0.370	0.582	0.520	1.720	D	T	D	D	D	D	4.550	32	0.999	D	D	0.627	6.207	0.578	5.963	1.000	0.707	0.725	0.702	0.714	.	4.650	4.650	2.436	1.176	0.676	1.000	0.993	0.994	758	.	.	.	ID=COSV57327587;OCCURENCE=1(large_intestine)	KCTD10	477	0	649	59	0.0833333333333333	TRUE	TRUE
ENSG00000089250.19	.	BCM	GRCh38.p13	chr12	117311466	117311466	+	C	C	A	Missense_Mutation	SNP	ENST00000317775.11	exon3	c.G852T	p.Q284H	exonic	ENSG00000089250.19	.	nonsynonymous SNV	ENSG00000089250.19:ENST00000317775.11:exon3:c.G852T:p.Q284H	12q24.22	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	T	T	P	B	D	D	L	T	N	0.526	T	T	T	0.088	0.253	0.509	0.444	T	T	T	T	D	D	3.897	26.300	0.995	D	D	0.500	5.039	0.556	5.718	0.975	0.554	0.574	0.602	0.564	.	5.650	5.650	5.112	1.016	0.587	1.000	0.978	0.876	888	.	.	.	.	NOS1	110	0	116	35	0.231788079470199	TRUE	TRUE
ENSG00000135090.14	.	BCM	GRCh38.p13	chr12	118161957	118161957	+	C	C	T	Missense_Mutation	SNP	ENST00000392533.8	exon18	c.G1970A	p.R657Q	exonic	ENSG00000135090.14	.	nonsynonymous SNV	ENSG00000135090.14:ENST00000392533.8:exon18:c.G1970A:p.R657Q	12q24.23	C3L-03123	8.237e-06	0	0	0	0	0	0	6.056e-05	rs753899938	5.20	T	T	B	B	D	D	N	T	N	0.130	T	T	T	0.132	0.321	0.420	1.135	T	T	T	T	D	D	2.210	20.900	0.875	D	N	-0.392	1.400	-0.078	2.111	0.999	0.706	0.702	0.710	0.714	.	5.550	5.550	2.508	1.026	0.599	0.996	1.000	0.998	967	.	.	.	ID=COSV101183383;OCCURENCE=1(central_nervous_system)	TAOK3	366	0	335	86	0.204275534441805	TRUE	NA
ENSG00000179195.16	.	BCM	GRCh38.p13	chr12	124012169	124012169	+	A	A	G	Missense_Mutation	SNP	ENST00000337815.9	exon5	c.A25G	p.R9G	exonic	ENSG00000179195.16	.	nonsynonymous SNV	ENSG00000179195.16:ENST00000337815.9:exon5:c.A25G:p.R9G	12q24.31	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	N	T	N	0.103	T	T	T	0.279	0.518	0.161	1.202	T	T	T	T	D	T	1.709	17.090	0.865	N	N	-0.571	1.041	-0.312	1.540	0.935	0.732	0.725	0.744	0.714	.	4.520	3.350	2.588	1.312	0.756	1.000	1.000	1.000	749	Zinc_finger_C2H2-type	.	.	.	ZNF664	151	0	146	34	0.188888888888889	TRUE	TRUE
ENSG00000151849.15	.	BCM	GRCh38.p13	chr13	24906317	24906317	+	T	T	C	Missense_Mutation	SNP	ENST00000381884.9	exon7	c.A1721G	p.E574G	exonic	ENSG00000151849.15	.	nonsynonymous SNV	ENSG00000151849.15:ENST00000381884.9:exon7:c.A1721G:p.E574G	13q12.13	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.799	T	T	D	0.400	0.244	0.852	0.621	T	T	D	D	D	D	4.216	28.800	0.999	D	D	0.849	9.820	0.835	11.243	1.000	0.707	0.725	0.651	0.636	.	6.030	6.030	7.309	1.126	0.665	1.000	1.000	0.998	884	.	.	.	.	CENPJ	59	0	82	9	0.0989010989010989	TRUE	TRUE
ENSG00000133119.13	.	BCM	GRCh38.p13	chr13	33825841	33825841	+	G	G	A	Missense_Mutation	SNP	ENST00000380071.8	exon4	c.G346A	p.A116T	exonic	ENSG00000133119.13	.	nonsynonymous SNV	ENSG00000133119.13:ENST00000380071.8:exon4:c.G346A:p.A116T	13q13.2	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.737	T	T	D	0.553	0.764	0.872	0.322	T	T	D	D	D	D	4.146	28.200	0.999	D	D	0.953	12.499	0.896	13.573	1.000	0.732	0.644	0.725	0.728	.	5.150	5.150	9.655	1.006	0.676	1.000	0.998	0.992	916	AAA+_ATPase_domain	.	.	.	RFC3	120	0	139	12	0.0794701986754967	TRUE	TRUE
ENSG00000172915.18	.	BCM	GRCh38.p13	chr13	35045400	35045400	+	C	C	T	Missense_Mutation	SNP	ENST00000400445.7	exon4	c.C722T	p.A241V	exonic	ENSG00000172915.18	.	nonsynonymous SNV	ENSG00000172915.18:ENST00000400445.7:exon4:c.C722T:p.A241V	13q13.3	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.856	D	D	D	0.619	0.645	0.294	1.820	D	D	D	T	D	D	4.674	32	0.999	D	D	0.807	8.919	0.810	10.419	1.000	0.615	0.588	0.659	0.621	.	5.670	5.670	7.637	1.026	0.599	1.000	1.000	1.000	938	.	.	.	ID=COSV59791392;OCCURENCE=1(large_intestine),1(stomach),1(lung)	NBEA	184	0	217	29	0.117886178861789	TRUE	TRUE
ENSG00000136104.21	.	BCM	GRCh38.p13	chr13	50934924	50934924	+	G	G	A	Missense_Mutation	SNP	ENST00000336617.8	exon5	c.G361A	p.V121M	exonic	ENSG00000136104.21	.	nonsynonymous SNV	ENSG00000136104.21:ENST00000336617.8:exon5:c.G361A:p.V121M	13q14.3	C3L-03123	8.442e-06	0	0	0	0	1.537e-05	0	0	rs764980431	3.20	T	T	B	B	N	N	N	D	N	0.145	T	D	D	0.209	0.330	0.493	0.051	T	T	T	T	T	T	-0.661	0.054	0.761	N	N	-1.389	0.122	-1.372	0.166	1.000	0.706	0.725	0.710	0.714	.	5.700	-1.540	-0.066	-0.428	-0.904	0.000	0.402	0.560	836	.	.	.	.	RNASEH2B	384	0	439	62	0.12375249500998	TRUE	NA
ENSG00000178235.8	.	BCM	GRCh38.p13	chr13	83879941	83879941	+	G	G	A	Nonsense_Mutation	SNP	ENST00000377084.3	exon1	c.C1567T	p.Q523X	exonic	ENSG00000178235.8	.	stopgain	ENSG00000178235.8:ENST00000377084.3:exon1:c.C1567T:p.Q523X	13q31.1	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.934	.	.	.	.	.	.	.	.	.	D	D	.	.	7.856	39	0.998	D	N	1.178	21.923	1.029	20.737	1.000	0.652	0.547	0.641	0.564	.	5.220	5.220	8.020	1.176	0.676	1.000	1.000	0.999	973	.	.	.	.	SLITRK1	372	1	361	50	0.121654501216545	TRUE	TRUE
ENSG00000198176.13	.	BCM	GRCh38.p13	chr13	113611043	113611043	+	G	G	T	Missense_Mutation	SNP	ENST00000375370.10	exon3	c.G60T	p.Q20H	exonic	ENSG00000198176.13	.	nonsynonymous SNV	ENSG00000198176.13:ENST00000375370.10:exon3:c.G60T:p.Q20H	13q34	C3L-03123	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	M	T	N	0.635	T	T	D	0.170	0.465	0.093	0.810	T	T	T	T	D	D	4.023	27.100	0.997	D	N	0.431	4.544	0.383	4.238	0.926	0.707	0.725	0.609	0.714	.	4.270	3.170	3.232	1.121	0.616	1.000	1.000	0.998	982	.	.	.	.	TFDP1	265	0	283	22	0.0721311475409836	TRUE	TRUE
ENSG00000187790.11	.	BCM	GRCh38.p13	chr14	45181673	45181673	+	G	G	T	Missense_Mutation	SNP	ENST00000267430.10	exon16	c.G4354T	p.A1452S	exonic	ENSG00000187790.11	.	nonsynonymous SNV	ENSG00000187790.11:ENST00000267430.10:exon16:c.G4354T:p.A1452S	14q21.2	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	D	T	D	P	N	N	M	T	N	0.470	T	T	T	0.088	0.161	0.469	0.234	T	T	T	T	D	T	3.490	24.700	0.996	D	N	0.202	3.314	0.257	3.474	1.000	0.615	0.634	0.659	0.655	.	5.250	4.360	2.774	1.161	0.618	0.991	0.997	0.998	815	.	.	.	.	FANCM	383	1	299	59	0.164804469273743	TRUE	TRUE
ENSG00000100614.18	.	BCM	GRCh38.p13	chr14	60289857	60289857	+	G	G	A	Missense_Mutation	SNP	ENST00000395076.9	exon4	c.G1004A	p.R335H	exonic	ENSG00000100614.18	.	nonsynonymous SNV	ENSG00000100614.18:ENST00000395076.9:exon4:c.G1004A:p.R335H	14q23.1	C3L-03123	8.411e-06	0	0	0.0001	0	0	0	0	rs755451132	8.20	T	T	B	B	D	D	L	T	N	0.691	T	T	T	0.168	0.707	0.700	1.047	D	T	D	T	D	D	2.812	23.000	0.997	D	D	0.123	2.977	0.318	3.824	1.000	0.732	0.725	0.630	0.728	.	5.360	5.360	8.068	1.176	0.618	1.000	1.000	0.996	491	Protein_serine/threonine_phosphatase_2C,_C-terminal	.	.	ID=COSV57785310;OCCURENCE=3(large_intestine)	PPM1A	176	0	145	36	0.198895027624309	TRUE	NA
ENSG00000099814.16	.	BCM	GRCh38.p13	chr14	104886377	104886377	+	C	C	T	Missense_Mutation	SNP	ENST00000414716.8	exon12	c.C2138T	p.A713V	exonic	ENSG00000099814.16	.	nonsynonymous SNV	ENSG00000099814.16:ENST00000414716.8:exon12:c.C2138T:p.A713V	14q32.33	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.160	T	T	T	0.015	0.205	0.110	0.176	T	T	T	T	T	T	0.668	8.162	0.953	N	N	-1.075	0.329	-1.113	0.362	0.215	0.707	0.588	0.723	0.714	.	4.830	0.253	1.208	-0.773	-0.193	0.003	0.052	0.022	976	.	.	.	.	CEP170B	214	0	226	46	0.169117647058824	TRUE	NA
ENSG00000170113.16	.	BCM	GRCh38.p13	chr15	22824211	22824211	+	T	T	C	Missense_Mutation	SNP	ENST00000337435.9	exon5	c.T962C	p.M321T	exonic	ENSG00000170113.16	.	nonsynonymous SNV	ENSG00000170113.16:ENST00000337435.9:exon5:c.T962C:p.M321T	15q11.2	C3L-03123	.	.	.	.	.	.	.	.	.	4.7	D	D	.	.	.	.	.	D	N	0.249	.	.	.	.	.	.	.	.	T	.	.	.	T	2.937	23.300	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	4.052	1.138	0.609	1.000	1.000	0.999	809	.	.	.	ID=COSV61680728;OCCURENCE=1(stomach)	NIPA1	294	0	360	28	0.0721649484536082	TRUE	TRUE
ENSG00000275835.5	.	BCM	GRCh38.p13	chr15	23022088	23022088	+	T	T	G	Missense_Mutation	SNP	ENST00000615383.5	exon11	c.A1242C	p.K414N	exonic	ENSG00000275835.5	.	nonsynonymous SNV	ENSG00000275835.5:ENST00000615383.5:exon11:c.A1242C:p.K414N	15q11.2	C3L-03123	2.471e-05	0	0	0	0	0	0	0.0002	.	1.4	.	T	.	.	.	.	.	.	.	0.583	.	.	.	.	.	.	.	.	T	.	.	.	D	2.715	22.900	.	.	N	.	.	.	.	.	.	.	.	.	.	.	.	1.603	1.138	0.665	1.000	1.000	0.997	773	.	.	.	.	TUBGCP5	532	1	594	66	0.1	TRUE	TRUE
ENSG00000128731.18	.	BCM	GRCh38.p13	chr15	28265882	28265882	+	G	G	A	Missense_Mutation	SNP	ENST00000261609.13	exon13	c.C1691T	p.A564V	exonic	ENSG00000128731.18	.	nonsynonymous SNV	ENSG00000128731.18:ENST00000261609.13:exon13:c.C1691T:p.A564V	15q13.1	C3L-03123	8.247e-06	0	0	0	0	1.501e-05	0	0	rs367923183	16.19	T	.	D	D	D	D	L	D	D	0.931	D	D	D	0.597	.	0.747	1.767	T	D	D	D	D	D	3.568	24.900	0.998	D	D	0.694	7.042	0.667	7.171	1.000	0.707	0.714	0.725	0.636	.	5.700	5.700	9.516	1.176	0.676	1.000	0.195	0.516	867	.	.	.	ID=COSV55356651;OCCURENCE=1(large_intestine)	HERC2	514	0	509	55	0.0975177304964539	TRUE	NA
ENSG00000169918.9	.	BCM	GRCh38.p13	chr15	31484076	31484076	+	C	C	T	Missense_Mutation	SNP	ENST00000307050.5	exon11	c.G1999A	p.A667T	exonic	ENSG00000169918.9	.	nonsynonymous SNV	ENSG00000169918.9:ENST00000307050.5:exon11:c.G1999A:p.A667T	15q13.3	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	D	T	P	B	U	D	L	T	N	0.143	T	T	D	0.052	0.232	0.168	.	D	T	T	T	D	D	2.056	19.680	0.998	D	D	0.023	2.592	0.051	2.544	1.000	0.598	0.588	0.666	0.639	.	3.930	3.000	3.491	0.072	-0.292	1.000	0.666	0.011	958	.	.	.	.	OTUD7A	184	0	229	28	0.108949416342412	TRUE	NA
ENSG00000198838.13	.	BCM	GRCh38.p13	chr15	33613240	33613240	+	T	T	C	Missense_Mutation	SNP	ENST00000634891.1	exon19	c.T2222C	p.V741A	exonic	ENSG00000198838.13	.	nonsynonymous SNV	ENSG00000198838.13:ENST00000634891.1:exon19:c.T2222C:p.V741A	15q14	C3L-03123	.	.	.	.	.	.	.	.	.	17.19	D	.	D	D	D	D	H	T	D	0.867	D	D	D	0.670	0.767	0.614	0.807	T	D	D	D	D	D	3.816	25.900	0.999	D	D	0.846	9.754	0.761	9.056	1.000	0.497	0.590	0.492	0.613	.	5.400	5.400	8.017	1.134	0.661	1.000	0.912	0.837	923	0.000	.	.	.	RYR3	419	0	474	36	0.0705882352941176	TRUE	TRUE
ENSG00000128829.12	.	BCM	GRCh38.p13	chr15	39976643	39976643	+	G	G	A	Missense_Mutation	SNP	ENST00000263791.10	exon12	c.G2048A	p.R683H	exonic	ENSG00000128829.12	.	nonsynonymous SNV	ENSG00000128829.12:ENST00000263791.10:exon12:c.G2048A:p.R683H	15q15.1	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.092	T	T	D	0.073	0.426	0.666	1.258	T	T	T	T	T	T	0.722	8.656	0.987	N	N	-1.046	0.357	-1.127	0.348	1.000	0.726	0.725	0.594	0.373	.	4.650	-2.340	-0.925	0.036	0.509	0.000	0.002	0.020	619	Protein_kinase_domain	.	.	.	EIF2AK4	308	0	376	53	0.123543123543124	TRUE	TRUE
ENSG00000137843.12	.	BCM	GRCh38.p13	chr15	40273407	40273407	+	C	C	T	Missense_Mutation	SNP	ENST00000560346.5	exon8	c.C1552T	p.H518Y	exonic	ENSG00000137843.12	.	nonsynonymous SNV	ENSG00000137843.12:ENST00000560346.5:exon8:c.C1552T:p.H518Y	15q15.1	C3L-03123	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.937	D	D	D	0.953	0.848	0.941	0.661	D	D	D	D	D	D	3.898	26.300	0.998	D	D	0.946	12.312	0.860	12.156	1.000	0.744	0.588	0.630	0.584	.	5.090	5.090	7.841	0.943	0.596	1.000	1.000	0.997	632	Protein_kinase_domain	.	.	.	PAK6	248	0	311	28	0.0825958702064897	TRUE	TRUE
ENSG00000159433.12	.	BCM	GRCh38.p13	chr15	42663368	42663368	+	C	C	A	Missense_Mutation	SNP	ENST00000290607.12	exon12	c.C956A	p.S319Y	exonic	ENSG00000159433.12	.	nonsynonymous SNV	ENSG00000159433.12:ENST00000290607.12:exon12:c.C956A:p.S319Y	15q15.2	C3L-03123	.	.	.	.	.	.	.	.	.	5.16	D	.	.	.	.	N	M	T	N	0.329	T	T	D	0.223	0.398	0.511	.	T	T	T	T	D	T	1.928	18.710	0.995	D	N	0.015	2.565	-0.003	2.348	1.000	0.563	0.654	0.602	0.492	.	4.270	4.270	2.120	1.022	0.545	0.008	0.624	0.611	93	Kinesin_motor_domain	.	.	.	STARD9	254	0	292	21	0.0670926517571885	TRUE	TRUE
ENSG00000140326.13	.	BCM	GRCh38.p13	chr15	42730598	42730598	+	C	C	T	Missense_Mutation	SNP	ENST00000356231.4	exon14	c.G2174A	p.R725Q	exonic	ENSG00000140326.13	.	nonsynonymous SNV	ENSG00000140326.13:ENST00000356231.4:exon14:c.G2174A:p.R725Q	15q15.2	C3L-03123	.	.	.	.	.	.	.	.	rs962870388	18.20	D	D	D	D	D	D	M	D	D	0.767	D	D	D	0.575	0.476	0.702	0.473	T	T	D	D	D	D	4.782	33	0.999	D	D	0.666	6.664	0.623	6.527	1.000	0.840	0.380	0.737	0.636	.	5.770	5.770	5.818	1.026	0.599	1.000	0.359	0.112	83	.	.	.	ID=COSV100661202;OCCURENCE=1(endometrium)	CDAN1	693	0	759	87	0.102836879432624	TRUE	NA
ENSG00000103995.14	.	BCM	GRCh38.p13	chr15	48748457	48748457	+	A	A	G	Missense_Mutation	SNP	ENST00000380950.7	exon22	c.T3620C	p.V1207A	exonic	ENSG00000103995.14	.	nonsynonymous SNV	ENSG00000103995.14:ENST00000380950.7:exon22:c.T3620C:p.V1207A	15q21.1	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	D	L	T	N	0.371	T	T	T	0.080	0.150	0.685	0.425	T	T	T	T	D	T	3.277	24.100	0.998	D	N	0.177	3.201	0.314	3.800	0.999	0.615	0.654	0.602	0.655	.	5.920	5.920	3.994	1.307	0.751	1.000	1.000	0.999	258	.	.	.	.	CEP152	119	0	126	24	0.16	TRUE	NA
ENSG00000198535.5	.	BCM	GRCh38.p13	chr15	62068582	62068582	+	C	C	A	Missense_Mutation	SNP	ENST00000355522.5	exon2	c.C969A	p.D323E	exonic	ENSG00000198535.5	.	nonsynonymous SNV	ENSG00000198535.5:ENST00000355522.5:exon2:c.C969A:p.D323E	15q22.2	C3L-03123	.	.	.	.	.	.	.	.	.	9.20	D	D	P	P	D	D	M	T	D	0.206	T	T	D	0.291	0.306	0.783	.	T	T	T	T	D	T	3.522	24.800	0.994	D	N	-0.087	2.216	-0.232	1.710	1.000	0.623	0.607	0.378	0.562	.	3.410	1.430	1.577	-0.308	0.522	1.000	0.068	0.844	868	.	.	.	.	C2CD4A	328	0	383	32	0.0771084337349398	TRUE	TRUE
ENSG00000028528.15	.	BCM	GRCh38.p13	chr15	64136915	64136915	+	C	C	A	Missense_Mutation	SNP	ENST00000559844.6	exon14	c.C1501A	p.L501I	exonic	ENSG00000028528.15	.	nonsynonymous SNV	ENSG00000028528.15:ENST00000559844.6:exon14:c.C1501A:p.L501I	15q22.31	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	D	D	D	P	D	D	L	T	N	0.528	T	T	T	0.276	0.585	0.253	0.798	T	T	T	T	D	D	2.985	23.400	0.985	D	N	-0.024	2.428	-0.031	2.258	1.000	0.737	0.702	0.733	0.714	.	5.660	5.660	0.786	1.026	0.599	0.251	0.992	0.979	337	Sorting_nexin_Vps5-like,_C-terminal	.	.	.	SNX1	93	0	127	13	0.0928571428571429	TRUE	TRUE
ENSG00000103591.13	.	BCM	GRCh38.p13	chr15	67231846	67231846	+	G	G	A	Missense_Mutation	SNP	ENST00000261880.10	exon5	c.C503T	p.A168V	exonic	ENSG00000103591.13	.	nonsynonymous SNV	ENSG00000103591.13:ENST00000261880.10:exon5:c.C503T:p.A168V	15q23	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.978	T	T	D	0.506	0.765	0.705	0.078	D	T	D	D	D	D	4.105	27.800	0.999	D	D	0.727	7.515	0.692	7.612	1.000	0.732	0.725	0.725	0.728	.	5.210	4.300	9.250	1.176	0.676	1.000	1.000	0.996	929	.	.	.	ID=COSV99971832;OCCURENCE=1(upper_aerodigestive_tract)	AAGAB	252	0	289	29	0.0911949685534591	TRUE	TRUE
ENSG00000103653.16	.	BCM	GRCh38.p13	chr15	74802448	74802448	+	C	C	T	Missense_Mutation	SNP	ENST00000220003.13	exon13	c.C1288T	p.R430W	exonic	ENSG00000103653.16	.	nonsynonymous SNV	ENSG00000103653.16:ENST00000220003.13:exon13:c.C1288T:p.R430W	15q24.1	C3L-03123	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	N	D	H	T	D	0.916	D	D	D	0.788	0.945	0.953	2.473	T	D	D	D	D	D	3.548	24.900	0.999	D	D	0.604	5.961	0.364	4.116	1.000	0.706	0.702	0.710	0.714	.	4.280	2.300	2.591	0.050	0.599	0.980	0.378	0.565	309	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	ID=COSV54974500;OCCURENCE=1(large_intestine),1(central_nervous_system)	CSK	384	1	470	54	0.103053435114504	TRUE	TRUE
ENSG00000188869.13	.	BCM	GRCh38.p13	chr15	81332840	81332840	+	C	C	T	Missense_Mutation	SNP	ENST00000359440.6	exon22	c.G2882A	p.R961H	exonic	ENSG00000188869.13	.	nonsynonymous SNV	ENSG00000188869.13:ENST00000359440.6:exon22:c.G2882A:p.R961H	15q25.1	C3L-03123	8.891e-06	0	0	0.0001	0	0	0	0	rs779434727	0.20	T	T	B	B	U	N	L	T	N	0.047	T	T	T	0.072	0.146	0.360	0.187	T	T	T	T	T	T	-0.050	1.052	0.976	N	N	-0.910	0.508	-0.959	0.541	1.000	0.554	0.547	0.602	0.542	.	5.310	0.120	-0.068	0.125	0.599	0.000	0.000	0.004	929	.	.	.	ID=COSV63923699;OCCURENCE=1(liver)	TMC3	167	0	193	23	0.106481481481481	TRUE	TRUE
ENSG00000183571.11	.	BCM	GRCh38.p13	chr15	98969537	98969537	+	C	C	T	Missense_Mutation	SNP	ENST00000378919.6	exon4	c.G259A	p.V87M	exonic	ENSG00000183571.11	.	nonsynonymous SNV	ENSG00000183571.11:ENST00000378919.6:exon4:c.G259A:p.V87M	15q26.3	C3L-03123	4.141e-05	0	0	0.0001	0.0002	4.498e-05	0	0	rs761032396	5.20	D	D	D	P	N	N	M	T	N	0.222	T	T	T	0.089	0.376	0.257	0.249	T	T	T	T	T	T	1.914	18.590	0.998	D	N	0.375	4.195	0.270	3.548	0.999	0.568	0.547	0.573	0.613	.	4.370	4.370	1.979	1.026	0.599	0.927	0.053	0.140	982	.	.	.	ID=COSV100967265;OCCURENCE=1(large_intestine),1(lung)	PGPEP1L	820	1	864	117	0.119266055045872	TRUE	NA
ENSG00000154237.13	.	BCM	GRCh38.p13	chr15	101027364	101027364	+	C	C	T	Nonsense_Mutation	SNP	ENST00000388948.8	exon18	c.C2509T	p.R837X	exonic	ENSG00000154237.13	.	stopgain	ENSG00000154237.13:ENST00000388948.8:exon18:c.C2509T:p.R837X	15q26.3	C3L-03123	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.903	.	.	.	.	.	.	.	.	.	D	D	.	.	8.127	41	0.996	D	N	0.271	3.634	0.002	2.367	1.000	0.672	0.702	0.608	0.636	.	5.340	-1.290	2.068	-0.352	0.599	0.997	0.485	0.915	854	.	.	.	.	LRRK1	155	0	178	20	0.101010101010101	TRUE	NA
ENSG00000063854.13	.	BCM	GRCh38.p13	chr16	1819127	1819127	+	C	C	T	Missense_Mutation	SNP	ENST00000397356.8	exon5	c.G529A	p.A177T	exonic	ENSG00000063854.13	.	nonsynonymous SNV	ENSG00000063854.13:ENST00000397356.8:exon5:c.G529A:p.A177T	16p13.3	C3L-03123	8.738e-06	0	8.956e-05	0	0	0	0	0	rs749671466	15.20	D	D	D	D	D	D	M	T	D	0.674	D	D	D	0.516	0.458	0.820	0.280	T	T	T	T	D	D	3.001	23.400	0.998	D	D	0.316	3.863	0.143	2.916	0.931	0.707	0.644	0.571	0.714	.	4.920	3.960	5.291	1.025	0.593	1.000	0.328	0.161	616	Hydroxyacylglutathione_hydrolase,_MBL_domain;Metallo-beta-lactamase	.	.	.	HAGH	133	0	155	20	0.114285714285714	TRUE	NA
ENSG00000131653.13	.	BCM	GRCh38.p13	chr16	2175146	2175146	+	T	T	C	Missense_Mutation	SNP	ENST00000326181.11	exon15	c.T1382C	p.I461T	exonic	ENSG00000131653.13	.	nonsynonymous SNV	ENSG00000131653.13:ENST00000326181.11:exon15:c.T1382C:p.I461T	16p13.3	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	P	P	D	D	M	T	D	0.942	T	T	D	0.710	0.646	0.775	2.373	D	T	D	D	D	D	3.873	26.200	0.993	D	D	0.528	5.264	0.498	5.141	0.999	0.672	0.702	0.702	0.711	.	5.310	4.220	2.776	1.138	0.665	1.000	1.000	0.991	637	WD40_repeat,_conserved_site;WD40-repeat-containing_domain	.	.	.	TRAF7	291	0	287	46	0.138138138138138	TRUE	TRUE
ENSG00000067365.15	.	BCM	GRCh38.p13	chr16	8642565	8642565	+	G	G	T	Missense_Mutation	SNP	ENST00000381920.8	exon9	c.G1010T	p.R337M	exonic	ENSG00000067365.15	.	nonsynonymous SNV	ENSG00000067365.15:ENST00000381920.8:exon9:c.G1010T:p.R337M	16p13.2	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	H	T	D	0.932	T	T	D	0.526	0.747	0.880	0.127	T	T	D	D	D	D	6.502	36	0.962	D	D	0.790	8.585	0.673	7.277	1.000	0.707	0.725	0.725	0.636	.	4.050	4.050	8.018	1.176	0.676	1.000	1.000	0.979	.	.	.	.	.	METTL22	255	0	320	57	0.151193633952255	TRUE	TRUE
ENSG00000103381.12	.	BCM	GRCh38.p13	chr16	12781200	12781200	+	T	T	C	Missense_Mutation	SNP	ENST00000381774.9	exon2	c.A274G	p.I92V	exonic	ENSG00000103381.12	.	nonsynonymous SNV	ENSG00000103381.12:ENST00000381774.9:exon2:c.A274G:p.I92V	16p13.12	C3L-03123	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	D	N	0.143	T	T	D	0.198	0.599	0.452	0.047	T	T	T	T	T	T	0.196	3.081	0.533	N	N	-0.989	0.416	-0.816	0.735	0.003	0.706	0.725	0.710	0.714	.	5.250	0.101	-0.243	-0.142	0.665	0.483	0.982	0.911	976	Calcineurin-like_phosphoesterase_domain,_ApaH_type	.	.	.	CPPED1	283	0	310	54	0.148351648351648	TRUE	TRUE
ENSG00000166847.10	.	BCM	GRCh38.p13	chr16	23665629	23665629	+	C	C	T	Missense_Mutation	SNP	ENST00000300087.7	exon5	c.C352T	p.R118C	exonic	ENSG00000166847.10	.	nonsynonymous SNV	ENSG00000166847.10:ENST00000300087.7:exon5:c.C352T:p.R118C	16p12.2	C3L-03123	8.283e-06	0	0	0	0	1.504e-05	0	0	rs373307086	12.20	T	T	B	B	D	D	M	T	D	0.866	T	T	D	0.577	.	0.831	2.151	D	D	T	D	D	D	3.861	26.100	0.995	D	D	0.239	3.481	0.336	3.935	1.000	0.707	0.702	0.725	0.714	.	5.500	4.550	7.291	1.026	0.599	1.000	0.996	0.988	379	.	.	.	ID=COSV55614942;OCCURENCE=3(large_intestine),1(lung)	DCTN5	177	0	178	32	0.152380952380952	TRUE	TRUE
ENSG00000140691.17	.	BCM	GRCh38.p13	chr16	31466651	31466651	+	G	G	A	Missense_Mutation	SNP	ENST00000268314.9	exon6	c.G2570A	p.R857H	exonic	ENSG00000140691.17	.	nonsynonymous SNV	ENSG00000140691.17:ENST00000268314.9:exon6:c.G2570A:p.R857H	16p11.2	C3L-03123	4.255e-05	0	0	0	0	3.717e-05	0	0.0001	rs780179674	1.20	T	T	B	B	N	D	L	T	N	0.172	T	T	T	0.017	.	0.184	0.746	T	T	T	T	T	T	0.748	8.890	0.992	N	N	-0.721	0.778	-0.597	1.050	0.958	0.732	0.702	0.744	0.636	.	5.070	1.990	0.031	0.222	0.665	0.000	0.755	0.602	371	.	.	.	.	ARMC5	160	0	236	24	0.0923076923076923	TRUE	NA
ENSG00000256812.2	.	BCM	GRCh38.p13	chr16	55567279	55567279	+	C	C	T	Missense_Mutation	SNP	ENST00000457326.3	exon1	c.C523T	p.R175W	exonic	ENSG00000256812.2	.	nonsynonymous SNV	ENSG00000256812.2:ENST00000457326.3:exon1:c.C523T:p.R175W	16q12.2	C3L-03123	.	.	.	.	.	.	.	.	rs981036666	9.19	D	D	D	P	.	D	M	T	D	0.392	T	T	D	0.275	0.569	0.694	0.331	T	T	T	T	D	T	3.882	26.200	0.999	D	N	0.472	4.824	0.447	4.712	1.000	0.487	0.574	0.574	0.323	.	5.980	3.850	2.349	1.018	0.599	0.971	0.983	0.995	719	EF-hand_domain	.	.	.	CAPNS2	218	1	255	35	0.120689655172414	TRUE	NA
ENSG00000159753.14	.	BCM	GRCh38.p13	chr16	67646484	67646484	+	C	C	A	Missense_Mutation	SNP	ENST00000334583.11	exon6	c.C433A	p.P145T	exonic	ENSG00000159753.14	.	nonsynonymous SNV	ENSG00000159753.14:ENST00000334583.11:exon6:c.C433A:p.P145T	16q22.1	C3L-03123	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	D	.	T	N	0.322	T	T	T	0.031	0.231	0.105	0.248	T	T	T	T	T	T	0.105	2.133	0.874	N	N	-1.076	0.328	-1.024	0.459	1.000	0.726	0.594	0.673	0.563	.	4.870	0.519	-0.157	-0.234	-0.175	0.000	0.004	0.009	45	.	.	.	.	CARMIL2	244	0	295	45	0.132352941176471	TRUE	TRUE
ENSG00000159792.10	.	BCM	GRCh38.p13	chr16	67909297	67909297	+	G	G	A	Missense_Mutation	SNP	ENST00000291041.6	exon2	c.G548A	p.R183H	exonic	ENSG00000159792.10	.	nonsynonymous SNV	ENSG00000159792.10:ENST00000291041.6:exon2:c.G548A:p.R183H	16q22.1	C3L-03123	0.0006	0.0003	0.0013	0	0.0005	0.0008	0	0	rs141391249	13.20	D	D	D	D	D	D	L	T	D	0.846	T	T	D	0.568	.	0.820	1.900	D	T	T	D	T	D	4.320	29.700	0.999	D	D	0.285	3.704	0.288	3.650	1.000	0.732	0.702	0.744	0.714	.	5.530	4.580	8.002	1.176	0.676	1.000	0.796	0.979	8	Protein_kinase_domain	.	.	ID=COSV52122721;OCCURENCE=2(large_intestine)	PSKH1	195	2	280	17	0.0572390572390572	TRUE	TRUE
ENSG00000132600.16	.	BCM	GRCh38.p13	chr16	68353508	68353508	+	G	G	A	Missense_Mutation	SNP	ENST00000339507.9	exon16	c.G1592A	p.R531Q	exonic	ENSG00000132600.16	.	nonsynonymous SNV	ENSG00000132600.16:ENST00000339507.9:exon16:c.G1592A:p.R531Q	16q22.1	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.935	T	T	T	0.440	0.626	0.664	0.620	T	T	D	D	D	D	4.852	33	0.999	D	D	0.954	12.544	0.939	15.514	1.000	0.707	0.725	0.725	0.714	.	5.950	5.950	9.250	1.176	0.671	1.000	1.000	1.000	42	.	.	.	.	PRMT7	198	0	247	43	0.148275862068966	TRUE	NA
ENSG00000140835.9	.	BCM	GRCh38.p13	chr16	71537616	71537616	+	G	G	T	Missense_Mutation	SNP	ENST00000338482.5	exon3	c.G939T	p.K313N	exonic	ENSG00000140835.9	.	nonsynonymous SNV	ENSG00000140835.9:ENST00000338482.5:exon3:c.G939T:p.K313N	16q22.2	C3L-03123	.	.	.	.	.	.	.	.	.	7.20	T	T	P	P	D	D	M	T	N	0.432	T	T	D	0.338	0.365	0.843	0.764	T	T	T	T	D	T	3.505	24.700	0.998	D	D	0.317	3.870	0.363	4.105	0.797	0.744	0.685	0.630	0.584	.	6.020	5.060	1.358	1.176	0.676	1.000	0.987	0.949	222	Sulfotransferase_domain	.	.	.	CHST4	355	0	404	48	0.106194690265487	TRUE	TRUE
ENSG00000102984.15	.	BCM	GRCh38.p13	chr16	71860380	71860380	+	G	G	A	Missense_Mutation	SNP	ENST00000425432.6	exon8	c.C877T	p.R293W	exonic	ENSG00000102984.15	.	nonsynonymous SNV	ENSG00000102984.15:ENST00000425432.6:exon8:c.C877T:p.R293W	16q22.2	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	L	T	D	0.738	T	T	D	0.236	0.247	0.320	2.032	D	T	D	D	D	D	4.105	27.800	0.999	D	D	0.585	5.775	0.565	5.813	0.990	0.745	0.702	0.732	0.636	.	5.750	4.780	3.516	0.161	0.676	1.000	0.996	0.999	81	.	.	.	.	ZNF821	557	0	629	74	0.105263157894737	TRUE	TRUE
ENSG00000141258.13	.	BCM	GRCh38.p13	chr17	2379468	2379468	+	G	G	A	Missense_Mutation	SNP	ENST00000426855.6	exon23	c.G2969A	p.R990Q	exonic	ENSG00000141258.13	.	nonsynonymous SNV	ENSG00000141258.13:ENST00000426855.6:exon23:c.G2969A:p.R990Q	17p13.3	C3L-03123	8.454e-06	0	0	0.0001	0	0	0	0	rs373345397	3.20	T	T	B	B	N	D	N	T	N	0.114	T	T	T	0.081	.	0.236	0.151	T	T	T	T	T	D	2.514	22.500	0.970	D	N	-0.539	1.101	-0.283	1.599	0.999	0.707	0.644	0.723	0.714	.	5.410	4.420	1.026	0.222	0.676	0.775	0.993	0.958	675	.	.	.	.	SGSM2	186	0	211	41	0.162698412698413	TRUE	NA
ENSG00000182327.8	.	BCM	GRCh38.p13	chr17	4789877	4789877	+	G	G	A	Missense_Mutation	SNP	ENST00000331264.8	exon4	c.G457A	p.A153T	exonic	ENSG00000182327.8	.	nonsynonymous SNV	ENSG00000182327.8:ENST00000331264.8:exon4:c.G457A:p.A153T	17p13.2	C3L-03123	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	.	N	0.037	T	T	T	0.092	0.549	0.030	0.794	T	T	T	T	T	T	0.542	6.940	0.843	N	N	-1.171	0.248	-1.175	0.304	1.000	0.437	0.166	0.504	0.604	.	4.590	-0.171	-0.425	-0.115	0.656	0.000	0.027	0.398	382	Glycolipid_transfer_protein_domain	.	.	.	GLTPD2	329	0	342	60	0.149253731343284	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674953	7674953	+	T	T	A	Missense_Mutation	SNP	ENST00000269305.8	exon6	c.A578T	p.H193L	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon6:c.A578T:p.H193L	17p13.1	C3L-03123	.	.	.	.	.	.	.	.	rs786201838	18.20	D	D	D	D	D	D	M	D	D	0.954	D	D	D	0.864	0.941	0.998	1.846	T	D	D	D	D	T	4.270	29.300	0.932	D	D	0.484	4.915	0.345	3.989	0.963	0.722	0.698	0.702	0.735	.	5.410	4.330	8.017	1.138	0.665	1.000	0.997	0.987	433	p53,_DNA-binding_domain	.	.	ID=COSV52663304;OCCURENCE=9(breast),4(liver),14(oesophagus),1(adrenal_gland),6(large_intestine),3(central_nervous_system),1(biliary_tract),6(ovary),6(haematopoietic_and_lymphoid_tissue),3(stomach),4(pancreas),2(skin),2(prostate),7(lung),18(upper_aerodigestive_tract),3(endometrium)	TP53	591	0	591	133	0.183701657458564	TRUE	TRUE
ENSG00000065325.13	.	BCM	GRCh38.p13	chr17	9836458	9836458	+	T	T	C	Missense_Mutation	SNP	ENST00000262441.10	exon3	c.T365C	p.L122S	exonic	ENSG00000065325.13	.	nonsynonymous SNV	ENSG00000065325.13:ENST00000262441.10:exon3:c.T365C:p.L122S	17p13.1	C3L-03123	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	N	D	.	T	D	0.905	D	D	D	0.664	0.732	0.951	1.153	T	T	D	D	D	T	4.343	29.900	0.999	D	D	0.865	10.184	0.804	10.244	1.000	0.487	0.574	0.547	0.613	.	5.480	5.480	6.945	1.138	0.665	1.000	1.000	0.999	922	GPCR,_family_2,_extracellular_hormone_receptor_domain	.	.	.	GLP2R	299	0	313	70	0.182767624020888	TRUE	TRUE
ENSG00000091536.19	.	BCM	GRCh38.p13	chr17	18121256	18121256	+	C	C	T	Missense_Mutation	SNP	ENST00000647165.2	exon2	c.C2456T	p.S819L	exonic	ENSG00000091536.19	.	nonsynonymous SNV	ENSG00000091536.19:ENST00000647165.2:exon2:c.C2456T:p.S819L	17p11.2	C3L-03123	.	.	.	.	.	.	.	.	.	8.19	D	D	D	B	.	N	M	D	N	0.356	T	T	D	0.289	0.276	0.724	.	D	T	T	T	T	T	1.833	17.970	0.992	D	N	-0.189	1.909	-0.241	1.691	0.095	0.517	0.547	0.479	0.563	.	4.360	4.360	0.112	0.835	0.439	0.000	0.009	0.006	247	.	.	.	.	MYO15A	165	0	141	19	0.11875	TRUE	TRUE
ENSG00000188522.15	.	BCM	GRCh38.p13	chr17	18977771	18977771	+	C	C	T	Missense_Mutation	SNP	ENST00000388995.11	exon5	c.G1895A	p.R632H	exonic	ENSG00000188522.15	.	nonsynonymous SNV	ENSG00000188522.15:ENST00000388995.11:exon5:c.G1895A:p.R632H	17p11.2	C3L-03123	5.232e-05	0.0001	0	0.0001	0	4.667e-05	0	7.349e-05	rs374490985	2.20	T	T	B	B	N	D	L	T	N	0.245	T	T	T	0.033	.	0.257	0.226	T	T	T	T	T	T	2.238	21.100	0.997	D	N	-0.247	1.747	-0.084	2.093	0.496	0.707	0.702	0.725	0.714	.	5.800	3.770	1.978	0.947	0.597	1.000	1.000	0.963	819	.	.	.	ID=COSV58756809;OCCURENCE=2(liver),1(endometrium)	FAM83G	157	0	128	21	0.140939597315436	TRUE	TRUE
ENSG00000188522.15	.	BCM	GRCh38.p13	chr17	18978827	18978827	+	G	G	A	Missense_Mutation	SNP	ENST00000388995.11	exon5	c.C839T	p.T280M	exonic	ENSG00000188522.15	.	nonsynonymous SNV	ENSG00000188522.15:ENST00000388995.11:exon5:c.C839T:p.T280M	17p11.2	C3L-03123	0.0002	0	0	0	0	3.111e-05	0	0.0012	rs746971207	7.20	T	T	D	D	D	D	L	T	N	0.694	T	T	T	0.248	0.481	0.560	1.709	T	T	T	T	T	D	3.062	23.500	0.999	D	D	0.531	5.284	0.567	5.839	0.999	0.707	0.725	0.725	0.636	.	5.220	5.220	6.237	1.176	0.674	1.000	0.779	0.649	819	.	.	.	.	FAM83G	173	0	209	49	0.189922480620155	TRUE	NA
ENSG00000141068.14	.	BCM	GRCh38.p13	chr17	27605509	27605509	+	C	C	T	Missense_Mutation	SNP	ENST00000644974.1	exon14	c.C1690T	p.R564W	exonic	ENSG00000141068.14	.	nonsynonymous SNV	ENSG00000141068.14:ENST00000644974.1:exon14:c.C1690T:p.R564W	17q11.2	C3L-03123	.	.	.	.	.	.	.	.	rs879225861	4.15	.	D	.	.	N	N	.	T	.	0.076	T	T	D	0.293	.	0.352	0.380	T	T	T	T	T	D	2.450	22.300	0.997	D	N	-0.305	1.602	-0.103	2.038	0.100	0.707	0.654	0.805	0.714	.	5.670	3.500	0.880	1.026	0.599	1.000	1.000	0.988	133	.	.	.	ID=COSV52028283;OCCURENCE=1(large_intestine)	KSR1	581	0	676	119	0.149685534591195	TRUE	TRUE
ENSG00000132589.16	.	BCM	GRCh38.p13	chr17	28883147	28883147	+	C	C	T	Missense_Mutation	SNP	ENST00000394908.9	exon4	c.G307A	p.V103I	exonic	ENSG00000132589.16	.	nonsynonymous SNV	ENSG00000132589.16:ENST00000394908.9:exon4:c.G307A:p.V103I	17q11.2	C3L-03123	8.288e-06	0	8.642e-05	0	0	0	0	0	rs777162321	6.20	T	T	B	B	D	D	N	D	N	0.352	T	T	D	0.357	.	0.756	0.449	T	T	T	T	T	D	1.641	16.640	0.908	D	N	-0.393	1.399	-0.093	2.066	1.000	0.672	0.702	0.702	0.711	.	5.670	5.670	3.247	1.026	0.599	0.996	1.000	0.998	221	Band_7_domain	.	.	ID=COSV67529033;OCCURENCE=1(liver),1(testis),1(endometrium)	FLOT2	310	0	364	57	0.135391923990499	TRUE	TRUE
ENSG00000270765.6	.	BCM	GRCh38.p13	chr17	35745986	35745986	+	G	G	T	Missense_Mutation	SNP	ENST00000604641.6	exon6	c.C1511A	p.P504H	exonic	ENSG00000270765.6	.	nonsynonymous SNV	ENSG00000270765.6:ENST00000604641.6:exon6:c.C1511A:p.P504H	17q12	C3L-03123	.	.	.	.	.	.	.	.	.	8.18	.	D	D	D	D	D	L	T	.	0.343	T	T	D	0.190	0.494	0.777	.	T	T	T	T	D	T	3.400	24.400	0.996	D	N	0.193	3.273	0.128	2.854	0.000	0.517	0.590	0.479	0.563	.	5.190	4.210	2.822	1.176	0.676	0.613	0.363	0.190	461	.	.	.	.	GAS2L2	91	0	105	13	0.110169491525424	TRUE	TRUE
ENSG00000033627.16	.	BCM	GRCh38.p13	chr17	42468069	42468069	+	C	C	A	Missense_Mutation	SNP	ENST00000343619.8	exon4	c.C256A	p.P86T	exonic	ENSG00000033627.16	.	nonsynonymous SNV	ENSG00000033627.16:ENST00000343619.8:exon4:c.C256A:p.P86T	17q21.2	C3L-03123	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.707	D	D	D	0.810	0.544	0.303	2.089	D	D	D	D	D	D	3.625	25.100	0.998	D	D	0.894	10.900	0.892	13.402	1.000	0.732	0.744	0.744	0.728	.	5.990	5.990	7.874	1.023	0.599	1.000	1.000	0.998	197	.	.	.	.	ATP6V0A1	199	0	273	30	0.099009900990099	TRUE	TRUE
ENSG00000182575.8	.	BCM	GRCh38.p13	chr17	49579101	49579101	+	G	G	A	Missense_Mutation	SNP	ENST00000328741.6	exon2	c.G560A	p.R187Q	exonic	ENSG00000182575.8	.	nonsynonymous SNV	ENSG00000182575.8:ENST00000328741.6:exon2:c.G560A:p.R187Q	17q21.33	C3L-03123	.	.	.	.	.	.	.	.	rs374258057	6.19	T	D	D	P	N	D	L	.	N	0.182	T	T	T	0.290	.	0.202	0.753	T	T	T	T	D	D	4.025	27.200	0.999	D	N	0.496	5.008	0.491	5.080	1.000	0.696	0.588	0.723	0.605	.	4.440	4.440	5.312	1.164	0.660	1.000	1.000	0.999	869	.	.	.	ID=COSV60872825;OCCURENCE=1(large_intestine)	NXPH3	394	1	511	55	0.0971731448763251	TRUE	TRUE
ENSG00000136449.15	.	BCM	GRCh38.p13	chr17	50531426	50531426	+	T	T	C	Nonstop_Mutation	SNP	ENST00000323776.11	exon19	c.T2824C	p.X942R	exonic	ENSG00000136449.15	.	stoploss	ENSG00000136449.15:ENST00000323776.11:exon19:c.T2824C:p.X942R	17q21.33	C3L-03123	.	.	.	.	.	.	.	.	.	0.4	.	.	.	.	.	N	.	.	.	0.016	.	.	.	.	.	.	.	.	.	T	T	.	.	0.639	7.890	0.840	N	.	0.344	4.016	0.024	2.444	1.000	0.119	0.060	0.068	0.128	0.054	5.310	4.200	0.907	1.138	0.654	0.153	0.063	0.025	940	.	.	.	.	MYCBPAP	207	0	263	39	0.129139072847682	TRUE	TRUE
ENSG00000154945.7	.	BCM	GRCh38.p13	chr17	50699720	50699720	+	C	C	T	Missense_Mutation	SNP	ENST00000285243.7	exon3	c.G457A	p.A153T	exonic	ENSG00000154945.7	.	nonsynonymous SNV	ENSG00000154945.7:ENST00000285243.7:exon3:c.G457A:p.A153T	17q21.33	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.103	T	T	T	0.034	0.333	0.143	0.289	T	T	T	T	T	T	1.294	14.340	0.717	N	N	-0.618	0.955	-0.566	1.097	1.000	0.707	0.725	0.725	0.714	.	5.070	4.080	2.855	1.026	0.599	0.056	0.840	0.947	878	.	.	.	ID=COSV53334620;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	ANKRD40	141	0	156	31	0.165775401069519	TRUE	TRUE
ENSG00000176160.11	.	BCM	GRCh38.p13	chr17	58487752	58487752	+	G	G	A	Missense_Mutation	SNP	ENST00000323777.8	exon1	c.C523T	p.P175S	exonic	ENSG00000176160.11	.	nonsynonymous SNV	ENSG00000176160.11:ENST00000323777.8:exon1:c.C523T:p.P175S	17q22	C3L-03123	.	.	.	.	.	.	.	.	.	2.15	D	T	.	.	N	N	.	T	N	0.228	T	T	T	0.055	0.261	0.297	1.383	T	.	T	T	T	.	1.770	17.520	0.917	D	N	-0.770	0.700	-0.675	0.935	1.000	0.422	0.600	0.596	0.555	.	3.550	2.570	1.109	1.137	0.587	0.978	0.207	0.048	307	.	.	.	.	HSF5	94	0	63	15	0.192307692307692	TRUE	TRUE
ENSG00000161509.14	.	BCM	GRCh38.p13	chr17	74850294	74850294	+	A	A	G	Missense_Mutation	SNP	ENST00000293190.10	exon6	c.T1403C	p.V468A	exonic	ENSG00000161509.14	.	nonsynonymous SNV	ENSG00000161509.14:ENST00000293190.10:exon6:c.T1403C:p.V468A	17q25.1	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.122	T	T	T	0.031	0.491	0.500	0.578	T	T	T	T	T	T	1.779	17.580	0.941	D	N	-0.554	1.073	-0.367	1.433	0.010	0.598	0.551	0.596	0.605	.	4.510	2.050	1.284	1.312	0.756	0.997	1.000	0.996	895	Ionotropic_glutamate_receptor,_L-glutamate_and_glycine-binding_domain;Ionotropic_glutamate_receptor	.	.	.	GRIN2C	419	2	504	80	0.136986301369863	TRUE	TRUE
ENSG00000183034.13	.	BCM	GRCh38.p13	chr17	74933527	74933527	+	G	G	T	Missense_Mutation	SNP	ENST00000331427.9	exon7	c.G1671T	p.E557D	exonic	ENSG00000183034.13	.	nonsynonymous SNV	ENSG00000183034.13:ENST00000331427.9:exon7:c.G1671T:p.E557D	17q25.1	C3L-03123	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	M	T	N	0.834	T	T	T	0.221	0.859	0.229	0.630	T	T	T	T	D	T	3.592	25.000	0.999	D	D	0.596	5.884	0.556	5.708	0.436	0.598	0.563	0.616	0.639	.	4.620	4.620	2.326	1.176	0.674	1.000	1.000	0.978	923	.	.	.	.	OTOP2	68	0	72	12	0.142857142857143	TRUE	TRUE
ENSG00000070495.14	.	BCM	GRCh38.p13	chr17	76723975	76723975	+	T	T	C	Missense_Mutation	SNP	ENST00000397625.8	exon3	c.A602G	p.Q201R	exonic	ENSG00000070495.14	.	nonsynonymous SNV	ENSG00000070495.14:ENST00000397625.8:exon3:c.A602G:p.Q201R	17q25.1	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	D	D	N	T	N	0.714	T	T	T	0.215	0.452	0.709	0.614	T	T	T	T	D	D	2.435	22.200	0.958	D	D	-0.102	2.169	0.122	2.826	1.000	0.745	0.672	0.732	0.735	.	5.160	5.160	8.006	1.129	0.654	1.000	1.000	0.997	822	JmjC_domain	.	.	.	JMJD6	508	0	571	103	0.152818991097923	TRUE	TRUE
ENSG00000187775.17	.	BCM	GRCh38.p13	chr17	78486285	78486285	+	T	T	C	Missense_Mutation	SNP	ENST00000389840.7	exon45	c.A7040G	p.Y2347C	exonic	ENSG00000187775.17	.	nonsynonymous SNV	ENSG00000187775.17:ENST00000389840.7:exon45:c.A7040G:p.Y2347C	17q25.3	C3L-03123	.	.	.	.	.	.	.	.	.	6.12	.	.	.	.	.	D	.	T	.	0.888	T	T	T	0.367	.	0.270	.	T	.	D	T	D	D	4.342	29.900	0.998	D	D	0.546	5.415	0.515	5.296	1.000	0.543	0.686	0.602	0.563	.	4.560	4.560	7.783	1.049	0.665	1.000	1.000	0.982	908	.	.	.	.	DNAH17	81	0	112	13	0.104	TRUE	TRUE
ENSG00000266074.8	.	BCM	GRCh38.p13	chr17	81442176	81442176	+	G	G	A	Missense_Mutation	SNP	ENST00000584436.7	exon5	c.G827A	p.R276H	exonic	ENSG00000266074.8	.	nonsynonymous SNV	ENSG00000266074.8:ENST00000584436.7:exon5:c.G827A:p.R276H	17q25.3	C3L-03123	0	0	0	0	0	0	0	0	rs782588265	6.19	T	T	B	B	.	D	M	T	N	0.542	T	T	D	0.082	0.252	0.048	0.510	T	T	T	T	D	D	3.258	24.000	0.999	D	N	-0.142	2.046	-0.098	2.052	0.595	0.646	0.547	0.576	0.700	.	3.770	3.770	1.390	1.160	0.597	0.034	0.997	0.734	.	.	.	.	.	BAHCC1	92	0	146	29	0.165714285714286	TRUE	NA
ENSG00000183010.17	.	BCM	GRCh38.p13	chr17	81933227	81933227	+	G	G	A	Missense_Mutation	SNP	ENST00000329875.13	exon7	c.C947T	p.A316V	exonic	ENSG00000183010.17	.	nonsynonymous SNV	ENSG00000183010.17:ENST00000329875.13:exon7:c.C947T:p.A316V	17q25.3	C3L-03123	1.664e-05	0	0	0	0	3.038e-05	0	0	rs781071840	2.20	T	T	B	B	N	N	M	T	N	0.099	T	T	D	0.190	0.084	0.567	0.121	T	T	T	T	T	T	0.826	9.650	0.515	N	N	-1.352	0.138	-1.417	0.143	0.989	0.672	0.698	0.644	0.711	.	3.460	-0.061	1.097	-0.120	-0.682	0.002	0.002	0.011	.	.	.	.	.	PYCR1	391	0	482	70	0.126811594202899	TRUE	NA
ENSG00000169710.9	.	BCM	GRCh38.p13	chr17	82093369	82093369	+	G	G	A	Nonsense_Mutation	SNP	ENST00000306749.4	exon5	c.C505T	p.Q169X	exonic	ENSG00000169710.9	.	stopgain	ENSG00000169710.9:ENST00000306749.4:exon5:c.C505T:p.Q169X	17q25.3	C3L-03123	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.923	.	.	.	.	.	.	.	.	.	D	D	.	.	6.115	35	0.997	D	N	0.467	4.790	0.206	3.214	1.000	0.672	0.702	0.702	0.711	.	4.770	2.630	4.548	0.223	-0.110	1.000	0.018	0.013	.	Polyketide_synthase,_beta-ketoacyl_synthase_domain;Beta-ketoacyl_synthase,_N-terminal	.	.	.	FASN	378	0	440	73	0.142300194931774	TRUE	TRUE
ENSG00000168675.18	.	BCM	GRCh38.p13	chr18	13621215	13621215	+	C	C	T	Missense_Mutation	SNP	ENST00000359446.9	exon4	c.C280T	p.R94W	exonic	ENSG00000168675.18	.	nonsynonymous SNV	ENSG00000168675.18:ENST00000359446.9:exon4:c.C280T:p.R94W	18p11.21	C3L-03123	.	.	.	.	.	.	.	.	rs948982534	6.20	T	T	B	B	D	D	L	T	D	0.413	T	T	T	0.070	.	0.380	.	T	T	T	T	D	D	2.395	22.100	0.993	D	N	-0.465	1.247	-0.341	1.483	1.000	0.635	0.644	0.602	0.586	.	5.580	2.710	2.942	0.129	-0.218	0.995	0.994	0.993	917	.	.	.	.	LDLRAD4	344	0	455	41	0.0826612903225806	TRUE	NA
ENSG00000101752.11	.	BCM	GRCh38.p13	chr18	21791552	21791552	+	C	C	T	Missense_Mutation	SNP	ENST00000261537.6	exon7	c.C1087T	p.L363F	exonic	ENSG00000101752.11	.	nonsynonymous SNV	ENSG00000101752.11:ENST00000261537.6:exon7:c.C1087T:p.L363F	18q11.2	C3L-03123	.	.	.	.	.	.	.	.	.	13.20	D	D	P	D	D	D	L	T	N	0.719	T	T	D	0.323	0.335	0.262	0.859	D	T	D	D	D	D	2.907	23.200	0.999	D	D	0.524	5.229	0.641	6.775	1.000	0.732	0.725	0.725	0.728	.	6.170	6.170	7.893	1.011	0.581	1.000	1.000	0.998	889	.	.	.	.	MIB1	132	0	159	20	0.111731843575419	TRUE	TRUE
ENSG00000215474.8	.	BCM	GRCh38.p13	chr18	47248100	47248100	+	C	C	T	Missense_Mutation	SNP	ENST00000425639.3	exon2	c.G1084A	p.V362M	exonic	ENSG00000215474.8	.	nonsynonymous SNV	ENSG00000215474.8:ENST00000425639.3:exon2:c.G1084A:p.V362M	18q21.1	C3L-03123	.	.	.	.	.	.	.	.	.	5.15	D	T	.	.	.	D	.	T	N	0.164	T	T	D	0.074	0.236	0.439	0.956	D	.	T	T	T	T	2.448	22.300	0.979	D	N	-0.280	1.663	-0.303	1.558	0.999	0.598	0.590	0.596	0.639	.	2.540	2.540	3.177	0.757	0.482	0.024	0.298	0.154	872	.	.	.	.	SKOR2	80	0	75	11	0.127906976744186	TRUE	NA
ENSG00000150637.9	.	BCM	GRCh38.p13	chr18	69895806	69895806	+	C	C	T	Missense_Mutation	SNP	ENST00000582621.6	exon3	c.G622A	p.V208I	exonic	ENSG00000150637.9	.	nonsynonymous SNV	ENSG00000150637.9:ENST00000582621.6:exon3:c.G622A:p.V208I	18q22.2	C3L-03123	7.413e-05	0.0004	0	0	0	0	0	0.0003	rs143019865	0.20	T	T	B	B	N	N	N	T	N	0.081	T	T	T	0.006	.	0.401	0.153	T	T	T	T	T	T	-1.362	0.001	0.747	N	N	-2.127	0.005	-2.199	0.005	1.000	0.722	0.699	0.006	0.564	.	4.820	-9.640	-2.138	-2.803	-1.604	0.000	0.000	0.000	994	Immunoglobulin_subtype_2;Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV54614593;OCCURENCE=1(large_intestine)	CD226	522	0	567	70	0.10989010989011	TRUE	TRUE
ENSG00000131196.17	.	BCM	GRCh38.p13	chr18	79451120	79451120	+	G	G	A	Missense_Mutation	SNP	ENST00000427363.6	exon5	c.G1756A	p.E586K	exonic	ENSG00000131196.17	.	nonsynonymous SNV	ENSG00000131196.17:ENST00000427363.6:exon5:c.G1756A:p.E586K	18q23	C3L-03123	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.920	T	T	D	0.496	0.583	0.624	2.011	D	D	D	D	D	D	4.654	32	0.999	D	D	0.693	7.018	0.585	6.046	0.999	0.672	0.702	0.645	0.636	.	4.650	4.650	7.544	1.121	0.676	1.000	0.941	0.663	.	Rel_homology_domain_(RHD),_DNA-binding_domain	.	.	ID=COSV99501587;OCCURENCE=1(skin),1(endometrium)	NFATC1	138	0	160	21	0.116022099447514	TRUE	TRUE
ENSG00000175221.15	.	BCM	GRCh38.p13	chr19	872001	872001	+	C	C	T	Missense_Mutation	SNP	ENST00000325464.6	exon12	c.G2023A	p.V675M	exonic	ENSG00000175221.15	.	nonsynonymous SNV	ENSG00000175221.15:ENST00000325464.6:exon12:c.G2023A:p.V675M	19p13.3	C3L-03123	.	.	.	.	.	.	.	.	.	6.20	D	D	P	P	U	D	L	T	N	0.661	T	T	D	0.068	0.374	0.384	.	T	T	T	T	D	D	3.677	25.300	0.999	N	N	0.326	3.919	0.292	3.670	1.000	0.718	0.644	0.269	0.553	.	3.960	2.830	2.403	1.016	0.582	0.985	0.987	0.988	994	.	.	.	.	MED16	340	0	437	50	0.102669404517454	TRUE	NA
ENSG00000115268.9	.	BCM	GRCh38.p13	chr19	1440401	1440401	+	T	T	C	Missense_Mutation	SNP	ENST00000592588.6	exon4	c.T377C	p.V126A	exonic	ENSG00000115268.9	.	nonsynonymous SNV	ENSG00000115268.9:ENST00000592588.6:exon4:c.T377C:p.V126A	19p13.3	C3L-03123	.	.	.	.	.	.	.	.	.	10.17	.	D	P	P	U	D	H	.	.	0.810	D	D	D	0.292	0.510	0.511	2.132	D	T	T	T	D	T	3.254	24.000	0.993	D	D	0.380	4.223	0.282	3.611	1.000	0.722	0.672	0.686	0.735	.	4.470	3.450	7.848	1.062	0.576	1.000	0.995	0.356	917	.	.	.	.	RPS15	886	0	889	134	0.130987292277615	TRUE	TRUE
ENSG00000186111.10	.	BCM	GRCh38.p13	chr19	3642935	3642935	+	G	G	A	Missense_Mutation	SNP	ENST00000335312.8	exon14	c.C1654T	p.R552C	exonic	ENSG00000186111.10	.	nonsynonymous SNV	ENSG00000186111.10:ENST00000335312.8:exon14:c.C1654T:p.R552C	19p13.3	C3L-03123	8.285e-06	9.666e-05	0	0	0	0	0	0	rs367846781	9.20	D	D	D	P	U	D	L	T	N	0.681	T	T	D	0.187	.	0.310	1.104	T	T	T	T	D	D	4.604	32	0.999	D	D	0.577	5.698	0.574	5.912	1.000	0.706	0.710	0.571	0.714	.	4.660	4.660	8.223	1.158	0.662	1.000	0.966	0.741	970	.	.	.	ID=COSV58951921;OCCURENCE=1(large_intestine),1(NS)	PIP5K1C	391	0	436	53	0.10838445807771	TRUE	TRUE
ENSG00000127663.15	.	BCM	GRCh38.p13	chr19	5134011	5134011	+	C	C	T	Missense_Mutation	SNP	ENST00000159111.9	exon14	c.C2035T	p.R679C	exonic	ENSG00000127663.15	.	nonsynonymous SNV	ENSG00000127663.15:ENST00000159111.9:exon14:c.C2035T:p.R679C	19p13.3	C3L-03123	8.354e-05	9.817e-05	0.0006	0	0	3.051e-05	0	0	rs140874022	2.19	T	D	P	B	N	N	.	T	N	0.369	T	T	T	0.065	.	0.159	1.092	T	T	T	T	T	D	2.042	19.580	0.992	N	N	-0.447	1.283	-0.566	1.098	0.850	0.707	0.698	0.723	0.714	.	3.980	2.920	1.604	1.026	0.599	0.001	0.006	0.044	970	.	.	.	ID=COSV50222952;OCCURENCE=1(biliary_tract)	KDM4B	259	0	279	35	0.111464968152866	TRUE	TRUE
ENSG00000171017.11	.	BCM	GRCh38.p13	chr19	7900687	7900687	+	G	G	A	Missense_Mutation	SNP	ENST00000306708.11	exon3	c.G2165A	p.R722H	exonic	ENSG00000171017.11	.	nonsynonymous SNV	ENSG00000171017.11:ENST00000306708.11:exon3:c.G2165A:p.R722H	19p13.2	C3L-03123	9.183e-05	0	0.0009	0	0	1.526e-05	0	0	rs190239641	1.20	T	T	B	B	N	N	N	T	N	0.077	T	T	T	0.023	.	0.607	0.317	T	T	T	T	T	T	1.879	18.330	0.987	D	N	-0.508	1.162	-0.454	1.279	1.000	0.646	0.547	0.645	0.568	.	4.350	2.070	2.594	0.245	0.618	0.985	0.649	0.111	879	.	.	.	ID=COSV100142867;OCCURENCE=1(stomach)	LRRC8E	230	0	287	37	0.114197530864198	TRUE	NA
ENSG00000076984.17	.	BCM	GRCh38.p13	chr19	7910330	7910330	+	G	G	A	Nonsense_Mutation	SNP	ENST00000397979.3	exon4	c.G404A	p.W135X	exonic	ENSG00000076984.17	.	stopgain	ENSG00000076984.17:ENST00000397979.3:exon4:c.G404A:p.W135X	19p13.2	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.808	.	.	.	.	.	.	.	.	.	D	D	.	.	8.607	44	0.995	D	N	1.090	17.093	0.947	15.909	0.654	0.707	0.702	0.702	0.714	.	5.310	5.310	3.367	1.174	0.676	1.000	1.000	0.996	874	Protein_kinase_domain	.	.	.	MAP2K7	309	1	297	59	0.165730337078652	TRUE	TRUE
ENSG00000127616.18	.	BCM	GRCh38.p13	chr19	10986949	10986949	+	C	C	-	Frame_Shift_Del	DEL	ENST00000344626.9	exon5	c.805delC	p.M272Cfs*31	exonic	ENSG00000127616.18	.	frameshift deletion	ENSG00000127616.18:ENST00000344626.9:exon5:c.805delC:p.M272Cfs*31	19p13.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMARCA4	337	0	396	47	0.106094808126411	NA	TRUE
ENSG00000008441.16	.	BCM	GRCh38.p13	chr19	13090316	13090316	+	G	G	A	Missense_Mutation	SNP	ENST00000592199.5	exon10	c.G1420A	p.A474T	exonic	ENSG00000008441.16	.	nonsynonymous SNV	ENSG00000008441.16:ENST00000592199.5:exon10:c.G1420A:p.A474T	19p13.13	C3L-03123	8.305e-06	0	0	0.0001	0	0	0	0	rs777228135	2.16	.	T	.	.	N	D	N	T	.	0.091	T	T	T	0.243	.	0.899	.	T	T	T	T	T	T	0.894	10.380	0.600	D	N	-0.438	1.302	-0.357	1.451	1.000	0.696	0.588	0.578	0.563	.	4.370	3.330	0.403	0.128	-0.247	0.998	1.000	0.994	798	.	.	.	.	NFIX	433	0	475	48	0.0917782026768642	TRUE	NA
ENSG00000074181.9	.	BCM	GRCh38.p13	chr19	15161579	15161579	+	G	G	A	Missense_Mutation	SNP	ENST00000263388.7	exon33	c.C6049T	p.H2017Y	exonic	ENSG00000074181.9	.	nonsynonymous SNV	ENSG00000074181.9:ENST00000263388.7:exon33:c.C6049T:p.H2017Y	19p13.12	C3L-03123	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	.	D	L	T	D	0.668	T	T	D	0.519	0.498	0.571	1.645	T	D	D	D	D	D	4.079	27.600	0.998	D	D	0.759	8.028	0.692	7.610	1.000	0.696	0.616	0.723	0.639	.	3.920	3.920	9.961	1.176	0.676	1.000	1.000	0.973	940	Ankyrin_repeat-containing_domain	.	.	.	NOTCH3	472	1	496	47	0.0865561694290976	TRUE	TRUE
ENSG00000127527.14	.	BCM	GRCh38.p13	chr19	16392420	16392420	+	A	A	G	Missense_Mutation	SNP	ENST00000248070.10	exon19	c.T1987C	p.F663L	exonic	ENSG00000127527.14	.	nonsynonymous SNV	ENSG00000127527.14:ENST00000248070.10:exon19:c.T1987C:p.F663L	19p13.11	C3L-03123	.	.	.	.	.	.	.	.	.	12.20	D	D	P	B	D	D	M	T	D	0.723	T	T	D	0.299	0.252	0.512	0.377	T	T	D	T	D	D	4.104	27.800	0.998	D	D	0.471	4.821	0.470	4.900	0.999	0.719	0.725	0.725	0.734	.	4.440	4.440	8.673	1.207	0.756	1.000	1.000	0.969	970	.	.	.	.	EPS15L1	263	0	294	44	0.130177514792899	TRUE	TRUE
ENSG00000085872.15	.	BCM	GRCh38.p13	chr19	16525347	16525347	+	G	G	A	Missense_Mutation	SNP	ENST00000546361.7	exon10	c.C1636T	p.R546C	exonic	ENSG00000085872.15	.	nonsynonymous SNV	ENSG00000085872.15:ENST00000546361.7:exon10:c.C1636T:p.R546C	19p13.11	C3L-03123	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	.	D	L	D	D	0.578	D	D	D	0.586	0.242	0.911	2.209	D	T	D	D	D	D	4.584	32	0.999	D	D	0.730	7.564	0.715	8.048	1.000	0.707	0.702	0.702	0.714	.	5.130	5.130	7.297	1.075	0.672	1.000	1.000	0.996	799	.	.	.	.	CHERP	50	0	50	12	0.193548387096774	TRUE	NA
ENSG00000099331.13	.	BCM	GRCh38.p13	chr19	17102118	17102118	+	G	G	A	Missense_Mutation	SNP	ENST00000594824.5	exon2	c.G401A	p.R134H	exonic	ENSG00000099331.13	.	nonsynonymous SNV	ENSG00000099331.13:ENST00000594824.5:exon2:c.G401A:p.R134H	19p13.11	C3L-03123	1.67e-05	0	0	0.0001	0	1.515e-05	0	0	rs201870397	11.18	T	D	.	.	N	D	L	D	D	0.196	D	D	D	0.335	.	0.798	1.802	T	T	T	T	D	D	3.568	24.900	0.999	D	D	0.222	3.404	0.311	3.779	1.000	0.707	0.702	0.725	0.714	.	5.620	5.620	6.286	1.083	0.676	1.000	0.582	0.787	964	.	.	.	.	MYO9B	403	0	384	63	0.140939597315436	TRUE	NA
ENSG00000105669.14	.	BCM	GRCh38.p13	chr19	18906991	18906991	+	G	G	A	Missense_Mutation	SNP	ENST00000262812.9	exon4	c.C412T	p.R138C	exonic	ENSG00000105669.14	.	nonsynonymous SNV	ENSG00000105669.14:ENST00000262812.9:exon4:c.C412T:p.R138C	19p13.11	C3L-03123	0	0	0	0	0	0	0	0	rs781041495	15.20	D	D	D	D	D	D	M	T	D	0.855	T	T	D	0.419	0.564	0.645	0.763	T	T	D	D	D	D	4.015	27.100	0.999	D	D	0.713	7.307	0.620	6.483	1.000	0.707	0.702	0.644	0.714	.	4.760	4.760	6.062	1.052	0.676	1.000	0.399	0.186	934	.	.	.	.	COPE	242	0	258	44	0.145695364238411	TRUE	NA
ENSG00000198597.9	.	BCM	GRCh38.p13	chr19	30443936	30443936	+	G	G	A	Missense_Mutation	SNP	ENST00000355537.4	exon2	c.G374A	p.R125H	exonic	ENSG00000198597.9	.	nonsynonymous SNV	ENSG00000198597.9:ENST00000355537.4:exon2:c.G374A:p.R125H	19q12	C3L-03123	.	.	.	.	.	.	.	.	rs866467288	11.20	D	D	D	D	D	D	L	T	N	0.808	T	T	T	0.304	0.456	0.134	2.089	D	T	T	T	D	D	4.196	28.600	0.998	D	D	0.411	4.410	0.454	4.763	0.999	0.487	0.574	0.578	0.613	.	5.800	5.800	8.182	1.175	0.676	1.000	0.974	0.988	777	.	.	.	ID=COSV62820141;OCCURENCE=2(large_intestine)	ZNF536	937	0	1126	87	0.0717230008244023	TRUE	TRUE
ENSG00000272333.7	.	BCM	GRCh38.p13	chr19	35720528	35720528	+	C	C	T	Missense_Mutation	SNP	ENST00000420124.4	exon3	c.C1181T	p.A394V	exonic	ENSG00000272333.7	.	nonsynonymous SNV	ENSG00000272333.7:ENST00000420124.4:exon3:c.C1181T:p.A394V	19q13.12	C3L-03123	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	.	N	N	T	N	0.031	T	T	D	0.024	.	0.159	.	T	T	T	T	T	T	-0.429	0.167	0.737	N	N	-1.576	0.060	-1.545	0.092	1.000	0.707	0.702	0.723	0.714	.	3.910	0.402	0.306	-1.548	-2.334	0.010	0.001	0.002	733	.	.	.	.	KMT2B	88	0	131	14	0.096551724137931	TRUE	NA
ENSG00000272333.7	.	BCM	GRCh38.p13	chr19	35733632	35733632	+	G	G	A	Missense_Mutation	SNP	ENST00000420124.4	exon29	c.G6995A	p.R2332H	exonic	ENSG00000272333.7	.	nonsynonymous SNV	ENSG00000272333.7:ENST00000420124.4:exon29:c.G6995A:p.R2332H	19q13.12	C3L-03123	2.406e-05	0	0	0	0	4.588e-05	0	0	rs758088530	13.20	D	D	D	D	N	D	L	D	N	0.223	D	D	D	0.512	0.405	0.445	.	T	T	D	T	D	D	3.148	23.700	0.997	D	N	0.442	4.612	0.446	4.699	0.986	0.672	0.702	0.723	0.711	.	5.190	5.190	2.717	1.172	0.672	0.997	0.968	0.530	713	.	.	.	ID=COSV55856608;OCCURENCE=1(endometrium)	KMT2B	296	0	358	67	0.157647058823529	TRUE	TRUE
ENSG00000105254.12	.	BCM	GRCh38.p13	chr19	36120784	36120784	+	A	A	C	Missense_Mutation	SNP	ENST00000221855.8	exon3	c.A333C	p.Q111H	exonic	ENSG00000105254.12	.	nonsynonymous SNV	ENSG00000105254.12:ENST00000221855.8:exon3:c.A333C:p.Q111H	19q13.12	C3L-03123	.	.	.	.	.	.	.	.	.	8.20	D	D	B	B	N	D	L	D	N	0.281	D	D	D	0.256	0.266	0.844	0.755	T	T	T	T	T	T	2.271	21.400	0.982	D	N	-0.324	1.556	-0.321	1.521	0.999	0.707	0.698	0.269	0.714	.	5.220	-1.150	-0.348	1.312	0.743	0.184	1.000	0.997	382	.	.	.	.	TBCB	209	0	287	17	0.0559210526315789	TRUE	TRUE
ENSG00000099341.11	.	BCM	GRCh38.p13	chr19	38380903	38380903	+	T	T	C	Missense_Mutation	SNP	ENST00000215071.8	exon5	c.T707C	p.L236P	exonic	ENSG00000099341.11	.	nonsynonymous SNV	ENSG00000099341.11:ENST00000215071.8:exon5:c.T707C:p.L236P	19q13.2	C3L-03123	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	H	.	D	0.985	D	T	D	0.824	0.901	0.797	1.275	D	D	D	D	D	D	4.416	31	0.999	D	D	0.861	10.087	0.812	10.487	1.000	0.707	0.698	0.725	0.714	.	5.560	5.560	7.748	1.138	0.665	1.000	1.000	0.985	603	Proteasome_component_(PCI)_domain;CSN8/PSMD8/EIF3K	.	.	.	PSMD8	88	0	162	15	0.0847457627118644	TRUE	TRUE
ENSG00000131116.12	.	BCM	GRCh38.p13	chr19	43607976	43607976	+	G	G	A	Missense_Mutation	SNP	ENST00000300811.8	exon3	c.C208T	p.R70C	exonic	ENSG00000131116.12	.	nonsynonymous SNV	ENSG00000131116.12:ENST00000300811.8:exon3:c.C208T:p.R70C	19q13.31	C3L-03123	5.112e-05	0	0	0	0	9.742e-05	0	0	rs759543944	11.20	D	T	D	D	D	D	N	T	D	0.633	T	T	D	0.225	0.333	0.397	1.411	D	T	T	T	D	D	3.939	26.600	0.999	D	N	0.447	4.647	0.466	4.862	1.000	0.672	0.702	0.644	0.711	.	4.700	4.700	2.959	1.172	0.672	1.000	0.984	0.971	895	.	.	.	ID=COSV100334614;OCCURENCE=1(lung)	ZNF428	466	0	593	64	0.0974124809741248	TRUE	NA
ENSG00000267680.5	.	BCM	GRCh38.p13	chr19	44107061	44107061	+	T	T	C	Missense_Mutation	SNP	ENST00000336976.10	exon6	c.T901C	p.S301P	exonic	ENSG00000267680.5	.	nonsynonymous SNV	ENSG00000267680.5:ENST00000336976.10:exon6:c.T901C:p.S301P	19q13.31	C3L-03123	.	.	.	.	.	.	.	.	.	6.19	D	D	D	P	.	N	M	T	D	0.136	T	T	T	0.102	0.603	0.233	0.475	T	T	T	T	D	T	2.455	22.300	0.992	N	N	-0.252	1.736	-0.493	1.214	0.005	0.707	0.702	0.725	0.636	.	2.770	2.770	-1.675	1.028	-0.194	0.000	0.005	0.094	610	Zinc_finger_C2H2-type	.	.	.	ZNF224	50	0	59	10	0.144927536231884	TRUE	TRUE
ENSG00000104884.16	.	BCM	GRCh38.p13	chr19	45361629	45361629	+	G	G	A	Missense_Mutation	SNP	ENST00000391945.10	exon12	c.C1132T	p.R378C	exonic	ENSG00000104884.16	.	nonsynonymous SNV	ENSG00000104884.16:ENST00000391945.10:exon12:c.C1132T:p.R378C	19q13.32	C3L-03123	8.285e-06	0	0	0	0	1.505e-05	0	0	rs186220206	19.20	D	D	D	D	D	D	M	T	D	0.908	D	D	D	0.677	.	0.910	0.939	D	D	D	D	D	D	4.538	32	0.999	D	D	0.743	7.766	0.616	6.431	0.999	0.719	0.702	0.723	0.714	.	5.540	5.540	3.440	1.176	0.676	1.000	0.900	0.097	900	Helical_and_beta-bridge_domain	.	.	.	ERCC2	220	0	280	33	0.105431309904153	TRUE	NA
ENSG00000105287.12	.	BCM	GRCh38.p13	chr19	46674545	46674545	+	G	G	A	Missense_Mutation	SNP	ENST00000433867.5	exon19	c.C2615T	p.A872V	exonic	ENSG00000105287.12	.	nonsynonymous SNV	ENSG00000105287.12:ENST00000433867.5:exon19:c.C2615T:p.A872V	19q13.32	C3L-03123	1.776e-05	0	0	0	0	0	0	0.0001	rs757479531	6.20	D	D	P	B	D	N	L	T	N	0.223	T	T	D	0.056	0.242	0.375	0.304	T	T	T	T	T	D	2.468	22.300	0.997	D	N	-0.055	2.322	-0.002	2.352	0.022	0.672	0.702	0.702	0.711	.	4.200	4.200	1.647	1.164	0.662	0.103	0.630	0.698	929	.	.	.	ID=COSV52188016;OCCURENCE=1(large_intestine)	PRKD2	211	0	206	35	0.145228215767635	TRUE	TRUE
ENSG00000105523.3	.	BCM	GRCh38.p13	chr19	48603592	48603592	+	C	C	T	Missense_Mutation	SNP	ENST00000263266.3	exon4	c.G1078A	p.A360T	exonic	ENSG00000105523.3	.	nonsynonymous SNV	ENSG00000105523.3:ENST00000263266.3:exon4:c.G1078A:p.A360T	19q13.33	C3L-03123	3.129e-05	0	0.0001	0	0	2.793e-05	0	0	rs747933011	0.20	T	T	B	B	N	N	N	T	N	0.067	T	T	T	0.032	0.187	0.040	0.233	T	T	T	T	T	T	0.398	5.401	0.955	N	N	-1.220	0.213	-1.220	0.267	0.001	0.581	0.547	0.576	0.563	.	4.450	-0.222	-0.435	0.130	0.589	0.000	0.001	0.014	884	.	.	.	.	FAM83E	144	0	201	15	0.0694444444444444	TRUE	NA
ENSG00000174951.11	.	BCM	GRCh38.p13	chr19	48750470	48750470	+	T	T	C	Missense_Mutation	SNP	ENST00000310160.7	exon4	c.A812G	p.N271S	exonic	ENSG00000174951.11	.	nonsynonymous SNV	ENSG00000174951.11:ENST00000310160.7:exon4:c.A812G:p.N271S	19q13.33	C3L-03123	.	.	.	.	.	.	.	.	.	15.20	T	T	D	D	D	D	M	D	D	0.565	D	D	D	0.540	0.750	0.988	1.142	T	T	D	D	D	T	2.769	23.000	0.984	D	D	0.316	3.863	0.156	2.976	1.000	0.707	0.610	0.725	0.636	.	4.460	4.460	4.851	1.138	0.665	1.000	0.239	0.044	867	.	.	.	.	FUT1	706	0	741	118	0.137369033760186	TRUE	TRUE
ENSG00000104804.8	.	BCM	GRCh38.p13	chr19	48888023	48888023	+	C	C	T	Missense_Mutation	SNP	ENST00000221399.8	exon8	c.G875A	p.R292H	exonic	ENSG00000104804.8	.	nonsynonymous SNV	ENSG00000104804.8:ENST00000221399.8:exon8:c.G875A:p.R292H	19q13.33	C3L-03123	8.261e-06	0	8.646e-05	0	0	0	0	0	rs768050219	19.20	D	D	D	D	D	D	H	D	D	0.739	D	D	D	0.757	0.948	0.885	0.641	T	D	D	D	D	D	3.198	23.900	0.999	D	D	0.458	4.726	0.230	3.332	0.906	0.653	0.588	0.676	0.613	.	4.630	3.590	6.015	0.975	0.594	1.000	0.004	0.001	720	Tubby,_C-terminal	.	.	.	TULP2	290	0	390	55	0.123595505617978	TRUE	NA
ENSG00000142530.11	.	BCM	GRCh38.p13	chr19	50467728	50467728	+	C	C	T	Missense_Mutation	SNP	ENST00000600100.6	exon4	c.G641A	p.R214Q	exonic	ENSG00000142530.11	.	nonsynonymous SNV	ENSG00000142530.11:ENST00000600100.6:exon4:c.G641A:p.R214Q	19q13.33	C3L-03123	.	.	.	.	.	.	.	.	rs919256556	0.17	.	T	B	B	N	N	L	.	.	0.185	T	T	T	0.025	0.400	0.067	0.209	T	T	T	T	T	T	0.771	9.108	0.796	N	N	-0.997	0.407	-0.949	0.554	0.436	0.706	0.574	0.710	0.568	.	4.000	2.960	-0.064	0.071	-0.193	0.014	0.091	0.013	809	Domain_of_unknown_function_DUF3699	.	.	.	FAM71E1	762	1	814	113	0.121898597626753	TRUE	NA
ENSG00000167754.13	.	BCM	GRCh38.p13	chr19	50949910	50949910	+	C	C	T	Missense_Mutation	SNP	ENST00000336334.8	exon3	c.G280A	p.G94R	exonic	ENSG00000167754.13	.	nonsynonymous SNV	ENSG00000167754.13:ENST00000336334.8:exon3:c.G280A:p.G94R	19q13.41	C3L-03123	3.365e-05	0.0002	0	0	0	1.536e-05	0	6.081e-05	rs780972904	18.20	D	D	D	D	U	D	H	D	D	0.898	D	D	D	0.839	.	0.991	0.545	T	D	D	D	D	D	4.077	27.600	0.999	D	D	0.803	8.848	0.620	6.480	1.000	0.534	0.574	0.686	0.613	.	4.430	4.430	4.788	1.026	0.599	0.998	0.771	0.845	923	Serine_proteases,_trypsin_domain	.	.	ID=COSV60451823;OCCURENCE=1(large_intestine)	KLK5	513	0	531	63	0.106060606060606	TRUE	TRUE
ENSG00000169035.12	.	BCM	GRCh38.p13	chr19	50977645	50977645	+	A	A	G	Missense_Mutation	SNP	ENST00000595820.6	exon6	c.T653C	p.L218P	exonic	ENSG00000169035.12	.	nonsynonymous SNV	ENSG00000169035.12:ENST00000595820.6:exon6:c.T653C:p.L218P	19q13.41	C3L-03123	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	U	D	M	D	D	0.739	D	D	D	0.774	0.869	0.973	0.285	T	D	D	D	D	D	3.968	26.800	0.999	D	D	0.526	5.244	0.452	4.747	0.991	0.554	0.588	0.602	0.613	.	4.900	4.900	7.737	1.311	0.686	0.822	0.992	0.898	912	Serine_proteases,_trypsin_domain	.	.	.	KLK7	349	0	432	48	0.1	TRUE	NA
ENSG00000179922.6	.	BCM	GRCh38.p13	chr19	55622151	55622151	+	G	G	A	Missense_Mutation	SNP	ENST00000325351.5	exon2	c.C572T	p.A191V	exonic	ENSG00000179922.6	.	nonsynonymous SNV	ENSG00000179922.6:ENST00000325351.5:exon2:c.C572T:p.A191V	19q13.42	C3L-03123	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	N	0.105	T	T	T	0.041	0.308	0.076	0.767	D	T	T	T	T	T	1.364	14.840	0.997	N	N	-0.917	0.499	-0.929	0.581	0.809	0.635	0.644	0.696	0.605	.	3.300	1.150	2.046	0.191	0.588	0.315	0.007	0.061	911	.	.	.	.	ZNF784	247	0	303	48	0.136752136752137	TRUE	NA
ENSG00000176293.19	.	BCM	GRCh38.p13	chr19	58067142	58067142	+	G	G	A	Missense_Mutation	SNP	ENST00000313434.9	exon5	c.G658A	p.G220R	exonic	ENSG00000176293.19	.	nonsynonymous SNV	ENSG00000176293.19:ENST00000313434.9:exon5:c.G658A:p.G220R	19q13.43	C3L-03123	.	.	.	.	.	.	.	.	rs374589646	3.18	D	D	P	B	.	N	.	T	D	0.169	T	T	T	0.098	.	0.126	0.127	T	T	T	T	T	T	2.204	20.900	0.828	N	N	-0.763	0.710	-0.879	0.649	0.000	0.563	0.574	0.609	0.568	.	3.510	2.460	0.458	0.177	-0.188	0.000	0.993	0.981	970	Zinc_finger_C2H2-type	.	.	ID=COSV57880516;OCCURENCE=1(large_intestine),1(skin)	ZNF135	476	0	516	79	0.132773109243697	NA	TRUE
ENSG00000083845.9	.	BCM	GRCh38.p13	chr19	58394540	58394540	+	G	G	A	Missense_Mutation	SNP	ENST00000196551.8	exon5	c.G491A	p.R164Q	exonic	ENSG00000083845.9	.	nonsynonymous SNV	ENSG00000083845.9:ENST00000196551.8:exon5:c.G491A:p.R164Q	19q13.43	C3L-03123	4.127e-05	0	0	0	0	7.512e-05	0	0	rs564673381	14.19	D	D	D	B	N	D	H	.	D	0.665	D	T	D	0.755	0.616	0.611	1.435	D	D	T	D	D	T	4.002	27.000	0.989	D	D	0.811	8.991	0.744	8.673	1.000	0.672	0.698	0.702	0.711	.	4.870	4.870	8.172	1.079	0.672	1.000	0.998	0.992	952	Ribosomal_protein_S7_domain	.	.	.	RPS5	439	0	498	48	0.0879120879120879	TRUE	NA
ENSG00000171574.18	.	BCM	GRCh38.p13	chr19	58417773	58417773	+	G	G	A	Missense_Mutation	SNP	ENST00000306910.9	exon4	c.G1255A	p.V419I	exonic	ENSG00000171574.18	.	nonsynonymous SNV	ENSG00000171574.18:ENST00000306910.9:exon4:c.G1255A:p.V419I	19q13.43	C3L-03123	4.341e-05	0.0002	0	0	0	4.634e-05	0	0	rs756765928	1.18	T	D	B	B	.	N	N	T	N	0.041	T	T	T	0.045	.	0.126	0.147	T	T	T	T	T	T	-1.189	0.002	0.608	N	.	-1.859	0.018	-1.969	0.016	0.999	0.615	0.654	0.659	0.636	.	4.110	-8.230	-1.844	-3.315	-1.710	0.000	0.000	0.001	929	.	.	.	.	ZNF584	80	0	114	17	0.129770992366412	TRUE	NA
ENSG00000088826.18	.	BCM	GRCh38.p13	chr20	4183629	4183629	+	C	C	T	Missense_Mutation	SNP	ENST00000305958.9	exon6	c.C1505T	p.P502L	exonic	ENSG00000088826.18	.	nonsynonymous SNV	ENSG00000088826.18:ENST00000305958.9:exon6:c.C1505T:p.P502L	20p13	C3L-03123	.	.	.	.	.	.	.	.	.	17.20	D	D	D	P	D	D	L	D	D	0.837	D	D	D	0.344	0.562	0.922	1.457	T	D	D	D	D	D	2.916	23.200	0.998	D	D	0.239	3.482	0.354	4.047	1.000	0.732	0.590	0.710	0.728	.	5.220	5.220	7.874	1.015	0.588	1.000	0.617	0.518	952	Amine_oxidase	.	.	.	SMOX	108	0	105	14	0.117647058823529	TRUE	NA
ENSG00000125848.10	.	BCM	GRCh38.p13	chr20	14325559	14325559	+	A	A	G	Nonstop_Mutation	SNP	ENST00000341420.5	exon3	c.T1948C	p.X650R	exonic	ENSG00000125848.10	.	stoploss	ENSG00000125848.10:ENST00000341420.5:exon3:c.T1948C:p.X650R	20p12.1	C3L-03123	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	0.301	.	.	.	.	.	.	.	.	.	T	T	.	.	1.904	18.520	0.907	D	.	1.237	27.622	1.115	28.891	1.000	0.075	0.063	0.060	0.102	0.969	6.160	6.160	9.325	1.312	0.756	1.000	1.000	1.000	513	.	.	.	.	FLRT3	89	0	95	13	0.12037037037037	TRUE	TRUE
ENSG00000171456.20	.	BCM	GRCh38.p13	chr20	32436109	32436109	+	T	T	C	Missense_Mutation	SNP	ENST00000375687.10	exon13	c.T3397C	p.S1133P	exonic	ENSG00000171456.20	.	nonsynonymous SNV	ENSG00000171456.20:ENST00000375687.10:exon13:c.T3397C:p.S1133P	20q11.21	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.114	T	T	T	0.012	0.109	0.130	0.070	T	T	T	T	T	T	0.245	3.645	0.500	N	N	-1.684	0.039	-1.729	0.045	1.000	0.707	0.702	0.725	0.711	.	4.560	-3.450	-0.308	-0.141	-0.688	0.000	0.002	0.004	516	.	.	.	.	ASXL1	256	0	281	40	0.124610591900312	TRUE	TRUE
ENSG00000125965.9	.	BCM	GRCh38.p13	chr20	35434336	35434336	+	G	G	A	Missense_Mutation	SNP	ENST00000374369.8	exon2	c.C1079T	p.A360V	exonic	ENSG00000125965.9;ENSG00000204183.2	.	nonsynonymous SNV	ENSG00000125965.9:ENST00000374369.8:exon2:c.C1079T:p.A360V,ENSG00000204183.2:ENST00000650879.1:exon2:c.G178A:p.A60T	20q11.22	C3L-03123	.	.	.	.	.	.	.	.	.	9.19	T	T	P	P	D	D	.	T	N	0.494	T	T	D	0.438	0.369	0.607	0.807	D	T	D	T	D	D	3.390	24.400	0.999	D	D	0.319	3.879	0.346	3.998	1.000	0.581	0.574	0.576	0.613	.	4.290	4.290	5.305	1.172	0.614	1.000	1.000	0.995	378	.	.	.	.	GDF5	751	0	797	83	0.0943181818181818	TRUE	TRUE
ENSG00000198959.12	.	BCM	GRCh38.p13	chr20	38156026	38156026	+	T	T	G	Missense_Mutation	SNP	ENST00000361475.7	exon3	c.A254C	p.E85A	exonic	ENSG00000198959.12	.	nonsynonymous SNV	ENSG00000198959.12:ENST00000361475.7:exon3:c.A254C:p.E85A	20q11.23	C3L-03123	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	L	D	N	0.223	T	T	D	0.157	0.371	0.443	0.246	T	T	T	T	T	T	1.335	14.640	0.391	D	N	-1.094	0.312	-1.137	0.339	1.000	0.722	0.634	0.618	0.735	.	5.300	-0.056	1.083	0.179	-0.133	0.010	0.006	0.002	882	Transglutaminase,_N-terminal	.	.	.	TGM2	455	1	507	63	0.110526315789474	TRUE	TRUE
ENSG00000124159.15	.	BCM	GRCh38.p13	chr20	45304603	45304603	+	C	C	T	Missense_Mutation	SNP	ENST00000372754.5	exon2	c.G268A	p.A90T	exonic	ENSG00000124159.15	.	nonsynonymous SNV	ENSG00000124159.15:ENST00000372754.5:exon2:c.G268A:p.A90T	20q13.12	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	N	T	N	0.078	T	T	T	0.149	0.283	0.678	0.428	T	T	T	T	T	T	1.955	18.910	0.914	D	N	-0.883	0.542	-0.733	0.853	0.002	0.598	0.588	0.576	0.639	.	4.640	2.630	2.634	0.947	0.599	0.992	0.276	0.450	872	von_Willebrand_factor,_type_A	.	.	ID=COSV59212550;OCCURENCE=1(large_intestine)	MATN4	105	0	131	17	0.114864864864865	TRUE	TRUE
ENSG00000124140.14	.	BCM	GRCh38.p13	chr20	46053677	46053677	+	C	C	T	Missense_Mutation	SNP	ENST00000454036.6	exon20	c.C2716T	p.R906C	exonic	ENSG00000124140.14	.	nonsynonymous SNV	ENSG00000124140.14:ENST00000454036.6:exon20:c.C2716T:p.R906C	20q13.12	C3L-03123	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.862	D	D	D	0.883	.	0.920	1.637	D	D	D	D	D	D	4.185	28.500	0.999	D	D	0.700	7.122	0.605	6.288	0.991	0.516	0.547	0.577	0.542	.	4.250	4.250	4.715	1.026	0.549	1.000	0.982	0.869	867	SLC12A_transporter,_C-terminal	.	.	ID=COSV54788554;OCCURENCE=1(large_intestine)	SLC12A5	126	0	190	12	0.0594059405940594	TRUE	TRUE
ENSG00000149635.3	.	BCM	GRCh38.p13	chr20	46541687	46541687	+	C	C	T	Missense_Mutation	SNP	ENST00000279028.3	exon3	c.G1288A	p.A430T	exonic	ENSG00000149635.3	.	nonsynonymous SNV	ENSG00000149635.3:ENST00000279028.3:exon3:c.G1288A:p.A430T	20q13.12	C3L-03123	.	.	.	.	.	.	.	.	.	9.20	D	D	D	D	N	D	M	T	N	0.603	T	T	D	0.192	0.773	0.177	.	T	T	T	T	D	T	3.757	25.600	0.999	D	N	0.487	4.933	0.495	5.114	0.996	0.520	0.627	0.441	0.542	.	5.060	5.060	2.220	1.026	0.599	0.996	0.969	0.882	958	Dendritic_cell-specific_transmembrane_protein-like	.	.	.	OCSTAMP	426	0	482	70	0.126811594202899	TRUE	TRUE
ENSG00000124098.10	.	BCM	GRCh38.p13	chr20	56365195	56365195	+	G	G	A	Missense_Mutation	SNP	ENST00000371384.4	exon2	c.G295A	p.V99I	exonic	ENSG00000124098.10	.	nonsynonymous SNV	ENSG00000124098.10:ENST00000371384.4:exon2:c.G295A:p.V99I	20q13.2	C3L-03123	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	L	T	N	0.230	T	T	T	0.137	0.612	0.173	0.840	T	T	T	T	D	T	2.089	19.930	0.994	D	D	-0.026	2.419	-0.057	2.176	1.000	0.706	0.634	0.710	0.714	.	5.360	4.410	6.639	1.176	0.613	1.000	0.064	0.591	988	Domain_of_unknown_function_DUF1279	.	.	.	FAM210B	216	0	225	29	0.114173228346457	TRUE	TRUE
ENSG00000054796.13	.	BCM	GRCh38.p13	chr20	57329895	57329895	+	G	G	A	Missense_Mutation	SNP	ENST00000371263.8	exon1	c.G28A	p.A10T	exonic	ENSG00000054796.13	.	nonsynonymous SNV	ENSG00000054796.13:ENST00000371263.8:exon1:c.G28A:p.A10T	20q13.31	C3L-03123	.	.	.	.	.	.	.	.	.	7.20	D	T	D	D	D	N	L	T	N	0.551	T	T	D	0.287	0.580	0.849	0.344	T	T	T	T	D	T	3.781	25.700	0.999	D	N	0.392	4.295	0.385	4.255	1.000	0.526	0.616	0.596	0.542	.	4.340	4.340	2.840	1.176	0.618	1.000	0.994	0.995	865	Meiosis-specific_protein_Spo11	.	.	.	SPO11	172	0	207	14	0.0633484162895928	TRUE	TRUE
ENSG00000087460.25	.	BCM	GRCh38.p13	chr20	58854241	58854241	+	G	G	A	Missense_Mutation	SNP	ENST00000371100.8	exon1	c.G976A	p.D326N	exonic	ENSG00000087460.25	.	nonsynonymous SNV	ENSG00000087460.25:ENST00000371100.8:exon1:c.G976A:p.D326N	20q13.32	C3L-03123	.	.	.	.	.	.	.	.	.	8.19	D	D	D	P	N	D	L	D	N	0.526	T	T	.	0.325	0.130	0.834	0.397	T	T	T	T	D	T	4.134	28.000	0.995	D	D	0.117	2.952	0.165	3.016	1.000	0.685	0.563	0.674	0.639	.	3.760	3.760	3.208	1.176	0.676	1.000	1.000	0.908	957	.	.	.	.	GNAS	168	0	205	31	0.13135593220339	TRUE	TRUE
ENSG00000101191.17	.	BCM	GRCh38.p13	chr20	62895056	62895056	+	G	G	A	Missense_Mutation	SNP	ENST00000395343.6	exon9	c.C2324T	p.A775V	exonic	ENSG00000101191.17	.	nonsynonymous SNV	ENSG00000101191.17:ENST00000395343.6:exon9:c.C2324T:p.A775V	20q13.33	C3L-03123	1.649e-05	0	0	0	0	1.499e-05	0	6.058e-05	rs566821138	1.20	D	T	P	B	N	N	L	T	N	0.162	T	T	T	0.052	0.479	0.277	0.602	T	T	T	T	T	T	1.467	15.520	0.994	N	N	-0.569	1.045	-0.617	1.021	0.999	0.672	0.709	0.702	0.711	.	5.520	3.520	0.496	1.176	0.676	0.000	0.001	0.004	798	Transcription_elongation_factor_S-II,_central_domain	.	.	.	DIDO1	75	0	115	12	0.094488188976378	TRUE	NA
ENSG00000130589.16	.	BCM	GRCh38.p13	chr20	63564552	63564552	+	G	G	A	Missense_Mutation	SNP	ENST00000467148.1	exon8	c.C4270T	p.R1424C	exonic	ENSG00000130589.16	.	nonsynonymous SNV	ENSG00000130589.16:ENST00000467148.1:exon8:c.C4270T:p.R1424C	20q13.33	C3L-03123	0.0002	0.0005	0	0	0	0.0003	0	0	rs369824033	13.20	D	D	D	D	D	D	M	T	D	0.487	T	T	D	0.590	.	0.508	0.369	T	T	T	D	D	D	3.723	25.500	0.999	D	N	0.503	5.056	0.364	4.116	0.897	0.651	0.644	0.645	0.684	.	4.660	3.690	2.903	1.083	0.618	1.000	0.277	0.184	.	Ribonuclease_II/R	.	.	ID=COSV71296095;OCCURENCE=1(large_intestine)	HELZ2	377	0	419	54	0.114164904862579	TRUE	TRUE
ENSG00000196700.9	.	BCM	GRCh38.p13	chr20	63962738	63962738	+	G	G	A	Missense_Mutation	SNP	ENST00000369888.6	exon13	c.C2012T	p.P671L	exonic	ENSG00000196700.9	.	nonsynonymous SNV	ENSG00000196700.9:ENST00000369888.6:exon13:c.C2012T:p.P671L	20q13.33	C3L-03123	1.333e-05	0	0	0	0	2.322e-05	0	0	rs375420745	0.20	T	T	B	B	N	N	N	T	N	0.028	T	T	T	0.010	.	0.043	.	T	T	T	T	T	T	1.140	13.140	0.811	N	N	-0.934	0.479	-0.796	0.764	0.118	0.672	0.702	0.702	0.636	.	5.220	1.220	0.946	0.297	-0.076	0.000	0.346	0.362	.	.	.	.	ID=COSV53866905;OCCURENCE=1(large_intestine)	ZNF512B	236	0	317	48	0.131506849315068	TRUE	TRUE
ENSG00000154736.6	.	BCM	GRCh38.p13	chr21	26965809	26965809	+	G	G	A	Missense_Mutation	SNP	ENST00000284987.6	exon1	c.C583T	p.R195C	exonic	ENSG00000154736.6	.	nonsynonymous SNV	ENSG00000154736.6:ENST00000284987.6:exon1:c.C583T:p.R195C	21q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	14.20	D	D	D	P	D	D	L	T	D	0.654	T	T	D	0.387	0.496	0.822	1.482	D	D	D	T	D	D	4.635	32	0.999	D	D	0.348	4.039	0.384	4.250	1.000	0.598	0.574	0.607	0.639	.	4.380	3.420	2.822	1.168	0.672	1.000	1.000	0.999	735	.	.	.	.	ADAMTS5	206	0	214	35	0.140562248995984	TRUE	TRUE
ENSG00000159128.14	.	BCM	GRCh38.p13	chr21	33421613	33421613	+	C	C	T	Missense_Mutation	SNP	ENST00000290219.10	exon3	c.C340T	p.R114C	exonic	ENSG00000159128.14	.	nonsynonymous SNV	ENSG00000159128.14:ENST00000290219.10:exon3:c.C340T:p.R114C	21q22.11	C3L-03123	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	N	M	D	D	0.873	D	D	D	0.603	.	1.000	1.445	T	D	D	D	D	D	3.565	24.900	0.997	N	N	-0.054	2.323	-0.295	1.575	1.000	0.707	0.702	0.658	0.714	.	4.530	3.640	1.819	0.084	-0.242	0.099	0.002	0.100	946	Fibronectin_type_III	.	.	.	IFNGR2	627	0	696	118	0.144963144963145	TRUE	NA
ENSG00000182240.16	.	BCM	GRCh38.p13	chr21	41226321	41226321	+	A	A	G	Missense_Mutation	SNP	ENST00000330333.11	exon2	c.A368G	p.H123R	exonic	ENSG00000182240.16	.	nonsynonymous SNV	ENSG00000182240.16:ENST00000330333.11:exon2:c.A368G:p.H123R	21q22.3	C3L-03123	.	.	.	.	.	.	.	.	.	5.20	D	T	P	B	D	N	M	T	D	0.638	T	T	T	0.197	0.579	0.597	1.002	T	T	T	T	D	T	1.990	19.180	0.916	N	N	-0.135	2.067	-0.253	1.665	1.000	0.706	0.590	0.710	0.714	.	4.740	4.740	3.816	1.298	0.740	0.454	0.127	0.068	969	Peptidase_family_A1_domain;Memapsin-like	.	.	.	BACE2	339	0	343	37	0.0973684210526316	TRUE	TRUE
ENSG00000142182.9	.	BCM	GRCh38.p13	chr21	44256100	44256100	+	G	G	A	Missense_Mutation	SNP	ENST00000628202.3	exon7	c.C571T	p.R191W	exonic	ENSG00000142182.9	.	nonsynonymous SNV	ENSG00000142182.9:ENST00000628202.3:exon7:c.C571T:p.R191W	21q22.3	C3L-03123	.	.	.	.	.	.	.	.	rs943771422	13.20	D	D	D	D	N	N	M	T	D	0.866	T	D	D	0.499	0.748	0.854	0.637	T	D	D	D	D	D	2.803	23.000	0.997	N	N	-0.031	2.404	-0.297	1.571	0.999	0.497	0.590	0.547	0.563	.	3.440	2.530	0.550	1.075	0.676	0.157	0.038	0.019	934	.	.	.	ID=COSV99533392;OCCURENCE=1(endometrium)	DNMT3L	269	0	291	38	0.115501519756839	TRUE	NA
ENSG00000099991.18	.	BCM	GRCh38.p13	chr22	24055016	24055016	+	C	C	T	Missense_Mutation	SNP	ENST00000263119.10	exon9	c.C950T	p.T317M	exonic	ENSG00000099991.18	.	nonsynonymous SNV	ENSG00000099991.18:ENST00000263119.10:exon9:c.C950T:p.T317M	22q11.23	C3L-03123	.	.	.	.	.	.	.	.	rs1056788500	4.20	D	D	B	B	N	N	L	T	N	0.254	T	T	D	0.049	0.203	0.632	0.291	T	T	T	T	T	T	0.681	8.279	0.980	D	N	-0.642	0.912	-0.629	1.003	0.992	0.732	0.725	0.744	0.714	.	5.350	4.330	2.594	1.001	0.597	0.061	0.008	0.039	923	.	.	.	ID=COSV54088980;OCCURENCE=1(large_intestine)	CABIN1	739	0	838	85	0.0920910075839653	TRUE	TRUE
ENSG00000099991.18	.	BCM	GRCh38.p13	chr22	24165607	24165607	+	C	C	T	Missense_Mutation	SNP	ENST00000263119.10	exon31	c.C4988T	p.T1663M	exonic	ENSG00000099991.18	.	nonsynonymous SNV	ENSG00000099991.18:ENST00000263119.10:exon31:c.C4988T:p.T1663M	22q11.23	C3L-03123	3.608e-05	0.0001	0	0.0002	0	1.617e-05	0	0	rs552263560	8.20	D	D	D	D	D	D	L	T	N	0.552	T	T	T	0.139	.	0.615	2.167	T	T	T	T	T	D	3.867	26.200	0.999	D	N	0.468	4.796	0.444	4.687	1.000	0.719	0.702	0.723	0.734	.	4.330	4.330	2.939	1.008	0.597	0.991	0.990	0.897	732	.	.	.	.	CABIN1	470	0	522	69	0.116751269035533	TRUE	NA
ENSG00000128294.16	.	BCM	GRCh38.p13	chr22	26541048	26541048	+	G	G	A	Missense_Mutation	SNP	ENST00000338754.9	exon3	c.C583T	p.R195C	exonic	ENSG00000128294.16	.	nonsynonymous SNV	ENSG00000128294.16:ENST00000338754.9:exon3:c.C583T:p.R195C	22q12.1	C3L-03123	8.269e-06	0	0	0	0	1.504e-05	0	0	rs749743940	15.20	D	T	D	P	D	D	M	T	D	0.951	T	T	D	0.510	0.683	0.740	1.701	D	D	D	D	D	D	4.289	29.500	0.999	D	D	0.339	3.985	0.267	3.532	1.000	0.707	0.725	0.698	0.714	.	5.010	4.000	2.764	1.176	0.676	0.999	1.000	0.989	975	.	.	.	.	TPST2	137	1	172	20	0.104166666666667	TRUE	NA
ENSG00000100154.14	.	BCM	GRCh38.p13	chr22	28014355	28014355	+	C	C	T	Missense_Mutation	SNP	ENST00000397906.6	exon14	c.G4111A	p.V1371M	exonic	ENSG00000100154.14	.	nonsynonymous SNV	ENSG00000100154.14:ENST00000397906.6:exon14:c.G4111A:p.V1371M	22q12.1	C3L-03123	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	N	D	N	0.181	T	T	D	0.246	0.227	0.184	.	T	T	T	T	T	D	0.195	3.064	0.604	N	N	-1.581	0.059	-1.627	0.068	0.998	0.707	0.670	0.717	0.714	.	4.750	-5.730	-0.333	-1.177	-0.780	0.003	0.002	0.026	952	.	.	.	.	TTC28	219	0	252	26	0.0935251798561151	TRUE	NA
ENSG00000100150.20	.	BCM	GRCh38.p13	chr22	31804188	31804188	+	G	G	T	Nonsense_Mutation	SNP	ENST00000646701.1	exon14	c.G1024T	p.G342X	exonic	ENSG00000100150.20;ENSG00000285404.1	.	stopgain	ENSG00000285404.1:ENST00000646701.1:exon14:c.G1024T:p.G342X,ENSG00000100150.20:ENST00000651528.2:exon16:c.G1108T:p.G370X	22q12.3	C3L-03123	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.963	.	.	.	.	.	.	.	.	.	D	D	.	.	7.945	40	0.993	D	N	1.171	21.422	1.018	20.015	1.000	0.707	0.725	0.651	0.636	.	5.250	5.250	8.785	1.158	0.671	1.000	1.000	0.990	196	.	.	.	.	DEPDC5	346	0	361	34	0.0860759493670886	TRUE	TRUE
ENSG00000100346.18	.	BCM	GRCh38.p13	chr22	39678009	39678009	+	C	C	A	Nonsense_Mutation	SNP	ENST00000402142.4	exon31	c.C4956A	p.C1652X	exonic	ENSG00000100346.18	.	stopgain	ENSG00000100346.18:ENST00000402142.4:exon31:c.C4956A:p.C1652X	22q13.1	C3L-03123	.	.	.	.	.	.	.	.	rs758332678	4.6	.	.	.	.	D	A	.	.	.	0.911	.	.	.	.	.	.	.	.	.	D	D	.	.	4.398	31	0.985	N	N	-0.221	1.818	-0.531	1.152	0.325	0.646	0.590	0.645	0.563	.	4.250	-3.500	-1.229	-2.002	-1.613	0.003	0.203	0.393	829	Ion_transport_domain	.	.	.	CACNA1I	192	0	234	35	0.130111524163569	TRUE	TRUE
ENSG00000100403.12	.	BCM	GRCh38.p13	chr22	41332210	41332210	+	G	G	A	Missense_Mutation	SNP	ENST00000352645.5	exon7	c.G565A	p.A189T	exonic	ENSG00000100403.12	.	nonsynonymous SNV	ENSG00000100403.12:ENST00000352645.5:exon7:c.G565A:p.A189T	22q13.2	C3L-03123	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.103	T	T	T	0.065	0.229	0.082	0.680	T	T	T	T	T	T	0.957	11.080	0.882	N	N	-0.948	0.462	-0.932	0.577	0.043	0.707	0.702	0.723	0.714	.	4.940	1.250	0.517	1.175	0.674	0.103	0.798	0.663	183	.	.	.	.	ZC3H7B	306	0	303	37	0.108823529411765	TRUE	TRUE
ENSG00000075240.17	.	BCM	GRCh38.p13	chr22	46672896	46672896	+	C	C	T	Missense_Mutation	SNP	ENST00000406902.6	exon14	c.C1138T	p.P380S	exonic	ENSG00000075240.17	.	nonsynonymous SNV	ENSG00000075240.17:ENST00000406902.6:exon14:c.C1138T:p.P380S	22q13.31	C3L-03123	.	.	.	.	.	.	.	.	rs1011786250	12.20	D	D	P	P	D	D	M	T	D	0.850	T	T	D	0.207	0.449	0.174	1.523	T	D	T	T	D	D	3.419	24.500	0.999	D	D	0.460	4.742	0.472	4.913	1.000	0.732	0.744	0.723	0.700	.	4.630	4.630	5.367	1.022	0.596	1.000	0.968	0.809	637	.	.	.	.	GRAMD4	265	0	345	55	0.1375	TRUE	NA
ENSG00000100253.13	.	BCM	GRCh38.p13	chr22	50489812	50489812	+	C	C	A	Missense_Mutation	SNP	ENST00000216075.11	exon10	c.C814A	p.Q272K	exonic	ENSG00000100253.13	.	nonsynonymous SNV	ENSG00000100253.13:ENST00000216075.11:exon10:c.C814A:p.Q272K	22q13.33	C3L-03123	.	.	.	.	.	.	.	.	.	8.18	T	T	P	B	D	D	.	.	D	0.540	T	T	D	0.180	0.671	0.122	0.259	T	T	T	T	D	D	2.873	23.200	0.937	D	D	0.437	4.578	0.461	4.825	0.965	0.554	0.588	0.576	0.613	.	4.690	3.640	4.568	1.022	0.596	1.000	0.998	0.986	794	.	.	.	.	MIOX	449	0	520	62	0.106529209621993	TRUE	TRUE
ENSG00000182378.14	.	BCM	GRCh38.p13	chrX	284293	284293	+	C	C	A	Missense_Mutation	SNP	ENST00000381657.8	exon2	c.C106A	p.L36I	exonic	ENSG00000182378.14	.	nonsynonymous SNV	ENSG00000182378.14:ENST00000381657.8:exon2:c.C106A:p.L36I	Xp22.33	C3L-03123	.	.	.	.	.	.	.	.	.	6.18	D	T	D	P	U	N	M	.	N	0.251	T	T	T	0.184	0.702	0.235	0.331	T	T	T	T	D	D	1.701	17.030	0.991	D	.	.	.	.	.	1.000	.	.	.	.	.	1.980	1.980	0.663	0.477	0.424	0.040	0.463	0.175	1000	Phosphatidylinositol-specific_phospholipase_C,_X_domain	.	.	.	PLCXD1	302	0	366	34	0.085	TRUE	TRUE
ENSG00000167393.18	.	BCM	GRCh38.p13	chrX	386592	386592	+	C	C	T	Missense_Mutation	SNP	ENST00000390665.9	exon1	c.G100A	p.D34N	exonic	ENSG00000167393.18	.	nonsynonymous SNV	ENSG00000167393.18:ENST00000390665.9:exon1:c.G100A:p.D34N	Xp22.33	C3L-03123	.	.	.	.	.	.	.	.	.	1.18	T	T	P	B	U	N	.	T	N	0.226	T	T	T	0.081	0.277	0.462	0.142	T	T	T	T	D	T	2.041	19.570	0.990	N	.	.	.	.	.	1.000	.	.	.	.	.	1.070	1.070	2.793	0.577	0.428	0.979	0.030	0.084	1000	.	.	.	.	PPP2R3B	307	0	424	31	0.0681318681318681	TRUE	TRUE
ENSG00000146938.16	.	BCM	GRCh38.p13	chrX	5893389	5893389	+	G	G	A	Nonsense_Mutation	SNP	ENST00000381095.8	exon6	c.C1879T	p.R627X	exonic	ENSG00000146938.16	.	stopgain	ENSG00000146938.16:ENST00000381095.8:exon6:c.C1879T:p.R627X	Xp22.32	C3L-03123	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	N	D	.	.	.	0.882	.	.	.	.	.	.	.	.	.	D	D	.	.	5.515	34	0.989	D	.	.	.	.	.	0.042	.	.	.	.	.	4.000	2.100	4.309	1.006	0.676	1.000	0.013	0.005	1000	.	.	.	ID=COSV52023286;OCCURENCE=1(endometrium)	NLGN4X	843	2	829	89	0.0969498910675381	NA	TRUE
ENSG00000046651.15	.	BCM	GRCh38.p13	chrX	13760282	13760282	+	A	A	T	Missense_Mutation	SNP	ENST00000340096.11	exon16	c.A1822T	p.I608F	exonic	ENSG00000046651.15	.	nonsynonymous SNV	ENSG00000046651.15:ENST00000340096.11:exon16:c.A1822T:p.I608F	Xp22.2	C3L-03123	.	.	.	.	.	.	.	.	.	6.19	T	T	D	P	N	N	M	D	N	0.226	D	D	D	0.289	0.595	0.886	0.676	T	T	T	T	T	T	0.637	7.864	0.795	N	.	.	.	.	.	1.000	.	.	.	.	.	5.550	-3.820	-0.153	-0.037	0.756	0.000	0.002	0.081	116	.	.	.	.	OFD1	423	0	461	62	0.118546845124283	TRUE	TRUE
ENSG00000130150.12	.	BCM	GRCh38.p13	chrX	14895391	14895391	+	T	T	A	Missense_Mutation	SNP	ENST00000380492.8	exon4	c.T319A	p.L107M	exonic	ENSG00000130150.12	.	nonsynonymous SNV	ENSG00000130150.12:ENST00000380492.8:exon4:c.T319A:p.L107M	Xp22.2	C3L-03123	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	D	D	M	T	N	0.613	T	T	D	0.386	0.676	0.426	1.482	T	T	T	T	D	D	2.912	23.200	0.997	D	.	.	.	.	.	0.991	.	.	.	.	.	4.540	3.370	1.768	1.138	0.665	1.000	1.000	0.999	120	CRAL-TRIO_lipid_binding_domain	.	.	.	MOSPD2	154	0	126	26	0.171052631578947	TRUE	TRUE
ENSG00000214107.8	.	BCM	GRCh38.p13	chrX	30251470	30251470	+	G	G	A	Missense_Mutation	SNP	ENST00000378981.7	exon4	c.G977A	p.R326H	exonic	ENSG00000214107.8	.	nonsynonymous SNV	ENSG00000214107.8:ENST00000378981.7:exon4:c.G977A:p.R326H	Xp21.2	C3L-03123	.	.	.	.	.	.	.	.	.	1.19	T	T	D	B	N	N	L	T	N	0.094	T	T	T	0.074	0.288	0.209	0.057	T	T	T	T	T	T	0.466	6.150	0.928	N	.	.	.	.	.	0.808	.	.	.	.	.	3.760	-0.457	-0.452	-0.208	0.676	0.000	0.001	0.002	738	.	.	.	ID=COSV66775656;OCCURENCE=1(large_intestine),1(skin),1(prostate)	MAGEB1	245	0	261	41	0.135761589403974	TRUE	TRUE
ENSG00000102226.10	.	BCM	GRCh38.p13	chrX	47233035	47233035	+	C	C	T	Missense_Mutation	SNP	ENST00000218348.7	exon1	c.C121T	p.R41W	exonic	ENSG00000102226.10	.	nonsynonymous SNV	ENSG00000102226.10:ENST00000218348.7:exon1:c.C121T:p.R41W	Xp11.3	C3L-03123	.	.	.	.	.	.	.	.	.	2.18	D	D	B	B	.	N	N	T	N	0.182	T	T	T	0.054	0.519	0.222	0.910	T	T	T	T	T	T	1.896	18.460	0.991	N	.	.	.	.	.	1.000	.	.	.	.	.	4.450	0.156	-0.094	0.124	0.596	0.006	0.035	0.082	548	.	.	.	ID=COSV52092520;OCCURENCE=1(endometrium)	USP11	488	0	633	76	0.107193229901269	TRUE	TRUE
ENSG00000187690.4	.	BCM	GRCh38.p13	chrX	51407287	51407287	+	G	G	A	Missense_Mutation	SNP	ENST00000342995.4	exon1	c.G271A	p.A91T	exonic	ENSG00000187690.4	.	nonsynonymous SNV	ENSG00000187690.4:ENST00000342995.4:exon1:c.G271A:p.A91T	Xp11.22	C3L-03123	1.259e-05	0	0	0	0	2.29e-05	0	0	rs781827373	0.17	T	T	P	B	N	N	.	T	N	0.063	T	T	T	0.228	0.247	0.453	0.061	.	T	T	T	T	T	-1.061	0.005	0.977	N	.	.	.	.	.	0.609	.	.	.	.	.	3.360	-6.710	-3.495	-0.947	-0.847	0.000	0.000	0.000	242	.	.	.	.	EZHIP	576	0	629	75	0.106534090909091	TRUE	TRUE
ENSG00000247746.4	.	BCM	GRCh38.p13	chrX	55488648	55488648	+	C	C	T	Missense_Mutation	SNP	ENST00000500968.3	exon2	c.G292A	p.V98I	exonic	ENSG00000247746.4	.	nonsynonymous SNV	ENSG00000247746.4:ENST00000500968.3:exon2:c.G292A:p.V98I	Xp11.21	C3L-03123	0.0002	0	0	0	0	0	0	0.0016	rs779961341	1.19	T	T	B	B	U	N	N	T	N	0.011	T	T	T	0.011	.	0.043	0.510	D	T	T	T	T	T	1.666	16.800	0.964	N	.	.	.	.	.	1.000	.	.	.	.	.	2.650	-0.596	0.124	0.006	0.514	0.000	0.519	0.883	280	.	.	.	.	USP51	223	0	283	28	0.090032154340836	TRUE	NA
ENSG00000131089.17	.	BCM	GRCh38.p13	chrX	63678504	63678504	+	T	T	G	Missense_Mutation	SNP	ENST00000253401.10	exon5	c.A630C	p.K210N	exonic	ENSG00000131089.17	.	nonsynonymous SNV	ENSG00000131089.17:ENST00000253401.10:exon5:c.A630C:p.K210N	Xq11.1	C3L-03123	.	.	.	.	.	.	.	.	.	6.19	T	D	B	B	D	D	N	T	N	0.393	T	T	T	0.087	0.452	0.690	1.157	D	T	T	T	T	D	1.011	11.770	0.403	D	.	.	.	.	.	0.002	.	.	.	.	.	5.080	-0.415	-0.102	-0.818	-0.883	0.720	0.991	0.984	26	Dbl_homology_(DH)_domain	.	.	.	ARHGEF9	215	0	264	31	0.105084745762712	TRUE	TRUE
ENSG00000120509.10	.	BCM	GRCh38.p13	chrX	70287336	70287336	+	C	C	A	Missense_Mutation	SNP	ENST00000239666.8	exon6	c.G328T	p.A110S	exonic	ENSG00000120509.10	.	nonsynonymous SNV	ENSG00000120509.10:ENST00000239666.8:exon6:c.G328T:p.A110S	Xq13.1	C3L-03123	.	.	.	.	.	.	.	.	.	11.19	D	D	P	B	D	D	M	T	D	0.795	T	T	D	0.422	0.714	0.589	1.969	T	T	D	T	D	D	4.414	31	0.996	D	.	.	.	.	.	1.000	.	.	.	.	.	4.880	4.880	7.157	0.998	0.531	1.000	1.000	0.997	45	PDZ_domain	.	.	.	PDZD11	313	0	395	33	0.0771028037383178	TRUE	TRUE
ENSG00000147206.17	.	BCM	GRCh38.p13	chrX	103079417	103079417	+	G	G	A	Missense_Mutation	SNP	ENST00000395065.8	exon15	c.C1277T	p.A426V	exonic	ENSG00000147206.17	.	nonsynonymous SNV	ENSG00000147206.17:ENST00000395065.8:exon15:c.C1277T:p.A426V	Xq22.1	C3L-03123	0.0021	0	0.0001	0.0002	0	4.168e-05	0.0047	0.0176	rs371513942	0.18	T	T	B	B	N	N	N	T	N	0.095	T	T	.	0.047	.	0.546	0.218	T	T	T	T	T	T	-0.889	0.015	0.556	N	.	.	.	.	.	0.000	.	.	.	.	.	4.220	-1.490	0.986	-2.607	-4.041	0.992	0.000	0.000	253	Nuclear_transport_factor_2,_eukaryote;Nuclear_transport_factor_2	.	.	ID=COSV67702792;OCCURENCE=2(large_intestine),1(biliary_tract)	NXF3	575	0	591	59	0.0907692307692308	NA	TRUE
ENSG00000123575.9	.	BCM	GRCh38.p13	chrX	104189648	104189648	+	G	G	A	Missense_Mutation	SNP	ENST00000493442.2	exon6	c.G1037A	p.R346H	exonic	ENSG00000123575.9	.	nonsynonymous SNV	ENSG00000123575.9:ENST00000493442.2:exon6:c.G1037A:p.R346H	Xq22.2	C3L-03123	1.14e-05	0	0.0001	0	0	0	0	0	rs782702516	12.19	D	D	D	D	D	D	L	T	D	0.585	T	T	D	0.341	0.307	0.309	2.553	D	T	T	T	D	D	4.246	29.100	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.070	5.070	9.943	1.175	0.676	1.000	1.000	1.000	471	.	.	.	ID=COSV55433623;OCCURENCE=1(stomach),2(thyroid)	FAM199X	514	2	540	52	0.0878378378378378	TRUE	TRUE
ENSG00000009694.13	.	BCM	GRCh38.p13	chrX	124520536	124520536	+	C	C	T	Nonsense_Mutation	SNP	ENST00000371130.7	exon18	c.G3282A	p.W1094X	exonic	ENSG00000009694.13	.	stopgain	ENSG00000009694.13:ENST00000371130.7:exon18:c.G3282A:p.W1094X	Xq25	C3L-03123	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	N	A	.	.	.	0.448	.	.	.	.	.	.	.	.	.	D	D	.	.	6.675	36	0.994	D	.	.	.	.	.	0.293	.	.	.	.	.	5.430	3.500	0.300	1.026	0.599	0.982	1.000	0.846	962	.	.	.	.	TENM1	119	0	112	19	0.145038167938931	TRUE	TRUE
ENSG00000129680.16	.	BCM	GRCh38.p13	chrX	136251305	136251305	+	C	C	A	Missense_Mutation	SNP	ENST00000316077.14	exon1	c.G54T	p.E18D	exonic	ENSG00000129680.16	.	nonsynonymous SNV	ENSG00000129680.16:ENST00000316077.14:exon1:c.G54T:p.E18D	Xq26.3	C3L-03123	.	.	.	.	.	.	.	.	.	0.18	T	T	P	P	.	N	N	T	N	0.061	T	T	T	0.040	0.106	0.328	0.183	T	T	T	T	T	T	0.304	4.330	0.521	N	.	.	.	.	.	1.000	.	.	.	.	.	3.070	-6.140	-1.425	0.083	0.542	0.000	0.002	0.002	789	.	.	.	.	MAP7D3	233	0	354	51	0.125925925925926	TRUE	TRUE
ENSG00000155495.9	.	BCM	GRCh38.p13	chrX	141908270	141908270	+	T	T	C	Missense_Mutation	SNP	ENST00000285879.5	exon4	c.T2866C	p.F956L	exonic	ENSG00000155495.9	.	nonsynonymous SNV	ENSG00000155495.9:ENST00000285879.5:exon4:c.T2866C:p.F956L	Xq27.2	C3L-03123	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	.	N	L	T	N	0.155	T	T	T	0.012	0.285	0.095	.	T	T	T	T	T	T	0.379	5.191	0.168	N	.	.	.	.	.	0.000	.	.	.	.	.	0.837	-0.771	-0.281	-0.467	-0.681	0.000	0.002	0.043	987	MAGE_homology_domain	.	.	.	MAGEC1	221	0	253	37	0.127586206896552	TRUE	TRUE
ENSG00000183479.12	.	BCM	GRCh38.p13	chrX	153444944	153444944	+	G	G	A	Missense_Mutation	SNP	ENST00000330912.6	exon13	c.C487T	p.R163W	exonic	ENSG00000183479.12	.	nonsynonymous SNV	ENSG00000183479.12:ENST00000330912.6:exon13:c.C487T:p.R163W	Xq28	C3L-03123	0.0001	0	0	0	0.0056	0	0	0	rs782383635	7.19	D	D	D	D	U	N	L	T	D	0.368	T	T	D	0.155	0.406	0.308	0.178	T	T	T	T	T	T	3.051	23.500	0.999	D	.	.	.	.	.	0.495	.	.	.	.	.	4.890	1.530	0.338	0.150	0.599	0.050	0.949	0.519	209	Exonuclease,_RNase_T/DNA_polymerase_III	.	.	.	TREX2	402	0	455	44	0.0881763527054108	TRUE	NA
ENSG00000089820.16	.	BCM	GRCh38.p13	chrX	153912708	153912708	+	A	A	G	Missense_Mutation	SNP	ENST00000350060.10	exon12	c.T1534C	p.F512L	exonic	ENSG00000089820.16	.	nonsynonymous SNV	ENSG00000089820.16:ENST00000350060.10:exon12:c.T1534C:p.F512L	Xq28	C3L-03123	.	.	.	.	.	.	.	.	.	10.19	D	D	D	P	D	D	N	T	D	0.665	T	T	D	0.264	0.296	0.554	0.197	T	T	T	T	D	D	4.072	27.500	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	5.460	5.460	8.984	1.312	0.756	1.000	1.000	0.998	180	Rho_GTPase-activating_protein_domain	.	.	.	ARHGAP4	130	0	177	29	0.140776699029126	TRUE	TRUE
ENSG00000142661.19	.	BCM	GRCh38.p13	chr1	24082716	24082716	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000142661.19	ENST00000374434.4:exon17:c.1971-2A>G	.	.	1p36.11	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.528	34	0.995	D	.	0.994	13.731	0.821	10.760	0.988	0.054	0.060	0.060	0.059	0.981	5.410	5.410	5.954	1.138	0.665	1.000	0.998	0.967	405	.	.	.	.	MYOM3	81	0	110	13	0.105691056910569	TRUE	TRUE
ENSG00000117595.12	.	BCM	GRCh38.p13	chr1	209796554	209796554	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000117595.12	ENST00000367021.8:exon4:c.175-2A>G	.	.	1q32.2	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.056	35	0.996	D	.	1.136	19.264	0.993	18.423	1.000	0.075	0.110	0.084	0.090	0.976	5.630	5.630	7.494	1.138	0.665	1.000	0.998	0.981	814	.	.	.	.	IRF6	362	0	418	67	0.138144329896907	TRUE	TRUE
ENSG00000204525.16	.	BCM	GRCh38.p13	chr6	31269527	31269527	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000204525.16	ENST00000376228.9:exon6:c.1016-2A>G	.	.	6p21.33	C3L-03123	.	.	.	.	.	.	.	.	.	1.5	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	3.753	25.600	0.913	N	N	0.236	3.465	-0.141	1.934	1.000	0.707	0.672	0.702	0.714	.	2.310	2.310	0.971	0.984	0.597	0.146	0.310	0.040	934	.	.	.	.	HLA-C	537	0	576	56	0.0886075949367089	TRUE	TRUE
ENSG00000096968.14	.	BCM	GRCh38.p13	chr9	5126448	5126448	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000096968.14	ENST00000381652.4:exon24:c.3291+2T>C	.	.	9p24.1	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.918	33	0.994	D	.	1.029	14.857	0.859	12.102	1.000	0.099	0.105	0.060	0.093	0.968	5.110	5.110	7.661	1.122	0.645	1.000	0.950	0.836	668	.	.	.	.	JAK2	142	0	129	25	0.162337662337662	TRUE	TRUE
ENSG00000106714.17	.	BCM	GRCh38.p13	chr9	39102495	39102495	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000106714.17	ENST00000297668.10:exon17:c.2755+2T>C	.	.	9p12	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.044	33	0.984	D	.	0.928	11.796	0.701	7.773	0.072	0.106	0.085	0.084	0.110	0.876	2.960	2.960	8.391	1.182	0.580	1.000	0.994	0.961	988	.	.	.	.	CNTNAP3	155	0	169	9	0.050561797752809	NA	TRUE
ENSG00000135070.15	.	BCM	GRCh38.p13	chr9	86272114	86272114	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000135070.15	ENST00000375991.9:exon3:c.136-2A>G	.	.	9q21.33	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	6.009	35	0.995	D	.	1.149	20.003	1.010	19.482	1.000	0.106	0.106	0.121	0.118	0.980	5.730	5.730	7.674	1.138	0.665	1.000	1.000	0.999	527	.	.	.	.	ISCA1	320	0	346	25	0.0673854447439353	TRUE	TRUE
ENSG00000148362.11	.	BCM	GRCh38.p13	chr9	136993666	136993666	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000148362.11	ENST00000371620.4:exon6:c.575+2T>C	.	.	9q34.3	C3L-03123	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	T	.	.	3.569	24.900	0.992	N	.	0.731	7.573	0.494	5.109	1.000	0.116	0.080	0.072	0.110	0.848	3.970	3.970	1.381	1.066	0.519	0.936	0.961	0.508	976	.	.	.	.	PAXX	366	0	452	51	0.101391650099404	TRUE	TRUE
ENSG00000005810.18	.	BCM	GRCh38.p13	chr13	77140046	77140046	+	C	C	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000005810.18	ENST00000544440.7:exon51:c.7518+1G>C	.	.	13q22.3	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	4.641	32	0.994	D	.	1.216	25.235	1.083	25.213	1.000	0.295	0.304	0.084	0.110	0.992	5.910	5.910	7.568	1.026	0.599	1.000	1.000	0.964	894	.	.	.	.	MYCBP2	114	0	151	23	0.132183908045977	TRUE	TRUE
ENSG00000140829.12	.	BCM	GRCh38.p13	chr16	72099889	72099889	+	T	T	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000140829.12	ENST00000268482.8:exon8:c.1116+2T>C	.	.	16q22.2	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.656	34	0.987	D	.	0.980	13.317	0.796	10.021	1.000	0.156	0.158	0.172	0.221	0.902	4.500	4.500	5.808	1.138	0.665	1.000	0.996	0.962	159	.	.	.	.	DHX38	206	0	219	27	0.109756097560976	TRUE	TRUE
ENSG00000067900.8	.	BCM	GRCh38.p13	chr18	21015429	21015429	+	A	A	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000067900.8	ENST00000399799.3:exon13:c.1410+2T>C	.	.	18q11.1	C3L-03123	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.218	33	0.994	D	.	1.106	17.772	0.960	16.562	1.000	0.322	0.319	0.060	0.082	0.977	5.500	5.500	6.369	1.312	0.756	1.000	1.000	1.000	530	.	.	.	.	ROCK1	271	0	312	40	0.113636363636364	TRUE	TRUE
ENSG00000187583.11	.	BCM	GRCh38.p13	chr1	970375	970375	+	A	A	G	Silent	SNP	ENST00000379410.8	exon3	c.A282G	p.G94G	exonic	ENSG00000187583.11	.	synonymous SNV	ENSG00000187583.11:ENST00000379410.8:exon3:c.A282G:p.G94G	1p36.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEKHN1	317	0	331	37	0.10054347826087	TRUE	TRUE
ENSG00000130762.15	.	BCM	GRCh38.p13	chr1	3473153	3473153	+	C	C	T	Silent	SNP	ENST00000378378.9	exon7	c.C1098T	p.H366H	exonic	ENSG00000130762.15	.	synonymous SNV	ENSG00000130762.15:ENST00000378378.9:exon7:c.C1098T:p.H366H	1p36.32	C3L-03123	8.315e-06	0	8.667e-05	0	0	0	0	0	rs764714977	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARHGEF16	249	0	331	36	0.0980926430517711	TRUE	NA
ENSG00000204859.13	.	BCM	GRCh38.p13	chr1	6588393	6588393	+	T	T	C	Silent	SNP	ENST00000377674.9	exon9	c.T1632C	p.H544H	exonic	ENSG00000204859.13	.	synonymous SNV	ENSG00000204859.13:ENST00000377674.9:exon9:c.T1632C:p.H544H	1p36.31	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZBTB48	107	0	122	14	0.102941176470588	TRUE	TRUE
ENSG00000158816.15	.	BCM	GRCh38.p13	chr1	20332861	20332861	+	C	C	T	Silent	SNP	ENST00000375079.6	exon12	c.C1668T	p.P556P	exonic	ENSG00000158816.15	.	synonymous SNV	ENSG00000158816.15:ENST00000375079.6:exon12:c.C1668T:p.P556P	1p36.12	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VWA5B1	382	0	442	40	0.0829875518672199	TRUE	NA
ENSG00000158022.6	.	BCM	GRCh38.p13	chr1	26057261	26057261	+	G	G	A	Silent	SNP	ENST00000374272.3	exon7	c.C921T	p.F307F	exonic	ENSG00000158022.6	.	synonymous SNV	ENSG00000158022.6:ENST00000374272.3:exon7:c.C921T:p.F307F	1p36.11	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRIM63	217	0	274	26	0.0866666666666667	TRUE	TRUE
ENSG00000117751.18	.	BCM	GRCh38.p13	chr1	27838788	27838788	+	G	G	T	Silent	SNP	ENST00000311772.10	exon3	c.G207T	p.R69R	exonic	ENSG00000117751.18	.	synonymous SNV	ENSG00000117751.18:ENST00000311772.10:exon3:c.G207T:p.R69R	1p35.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPP1R8	226	0	257	16	0.0586080586080586	TRUE	NA
ENSG00000204084.13	.	BCM	GRCh38.p13	chr1	37945827	37945827	+	C	C	T	Silent	SNP	ENST00000373023.6	exon3	c.G81A	p.E27E	exonic	ENSG00000204084.13	.	synonymous SNV	ENSG00000204084.13:ENST00000373023.6:exon3:c.G81A:p.E27E	1p34.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INPP5B	184	0	281	21	0.0695364238410596	TRUE	TRUE
ENSG00000127603.29	.	BCM	GRCh38.p13	chr1	39336239	39336239	+	T	T	C	Silent	SNP	ENST00000372915.7	exon36	c.T9666C	p.S3222S	exonic	ENSG00000127603.29	.	synonymous SNV	ENSG00000127603.29:ENST00000372915.7:exon36:c.T9666C:p.S3222S	1p34.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MACF1	146	0	145	22	0.131736526946108	TRUE	NA
ENSG00000117385.16	.	BCM	GRCh38.p13	chr1	42750235	42750235	+	C	C	T	Silent	SNP	ENST00000296388.10	exon11	c.G1671A	p.T557T	exonic	ENSG00000117385.16	.	synonymous SNV	ENSG00000117385.16:ENST00000296388.10:exon11:c.G1671A:p.T557T	1p34.2	C3L-03123	1.757e-05	0	0	0	0	1.58e-05	0	6.552e-05	rs772912578	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52531745;OCCURENCE=1(stomach)	P3H1	361	0	366	42	0.102941176470588	TRUE	TRUE
ENSG00000081985.12	.	BCM	GRCh38.p13	chr1	67367913	67367913	+	T	T	C	Silent	SNP	ENST00000262345.5	exon10	c.T1347C	p.S449S	exonic	ENSG00000081985.12	.	synonymous SNV	ENSG00000081985.12:ENST00000262345.5:exon10:c.T1347C:p.S449S	1p31.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IL12RB2	735	2	818	104	0.112798264642082	TRUE	TRUE
ENSG00000134186.12	.	BCM	GRCh38.p13	chr1	108696174	108696174	+	G	G	A	Silent	SNP	ENST00000370025.9	exon3	c.G477A	p.A159A	exonic	ENSG00000134186.12	.	synonymous SNV	ENSG00000134186.12:ENST00000370025.9:exon3:c.G477A:p.A159A	1p13.3	C3L-03123	2.473e-05	0	0	0	0	1.499e-05	0	0.0001	rs770782317	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64223659;OCCURENCE=2(large_intestine),1(endometrium)	PRPF38B	153	0	183	20	0.0985221674876847	TRUE	TRUE
ENSG00000163554.15	.	BCM	GRCh38.p13	chr1	158661357	158661357	+	C	C	A	Silent	SNP	ENST00000643759.2	exon18	c.G2517T	p.L839L	exonic	ENSG00000163554.15	.	synonymous SNV	ENSG00000163554.15:ENST00000643759.2:exon18:c.G2517T:p.L839L	1q23.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPTA1	751	1	723	83	0.102977667493797	TRUE	TRUE
ENSG00000116690.13	.	BCM	GRCh38.p13	chr1	186312866	186312866	+	C	C	T	Silent	SNP	ENST00000445192.7	exon12	c.C4089T	p.D1363D	exonic	ENSG00000116690.13	.	synonymous SNV	ENSG00000116690.13:ENST00000445192.7:exon12:c.C4089T:p.D1363D	1q31.1	C3L-03123	0.0001	9.612e-05	0	0	0.0002	0.0002	0.0011	0.0002	rs145515394	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63355709;OCCURENCE=1(stomach),1(lung)	PRG4	280	0	315	39	0.110169491525424	TRUE	TRUE
ENSG00000081237.20	.	BCM	GRCh38.p13	chr1	198741964	198741964	+	A	A	G	Silent	SNP	ENST00000442510.8	exon24	c.A2499G	p.K833K	exonic	ENSG00000081237.20	.	synonymous SNV	ENSG00000081237.20:ENST00000442510.8:exon24:c.A2499G:p.K833K	1q32.1	C3L-03123	.	.	.	.	.	.	.	.	rs975797535	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PTPRC	487	0	609	64	0.0950965824665676	TRUE	NA
ENSG00000042781.14	.	BCM	GRCh38.p13	chr1	215867098	215867098	+	C	C	T	Silent	SNP	ENST00000307340.8	exon44	c.G8754A	p.V2918V	exonic	ENSG00000042781.14	.	synonymous SNV	ENSG00000042781.14:ENST00000307340.8:exon44:c.G8754A:p.V2918V	1q41	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	USH2A	335	0	381	39	0.0928571428571429	TRUE	TRUE
ENSG00000143772.9	.	BCM	GRCh38.p13	chr1	226736679	226736679	+	A	A	G	Silent	SNP	ENST00000429204.5	exon2	c.T780C	p.G260G	exonic	ENSG00000143772.9	.	synonymous SNV	ENSG00000143772.9:ENST00000429204.5:exon2:c.T780C:p.G260G	1q42.12	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITPKB	205	0	235	16	0.0637450199203187	TRUE	TRUE
ENSG00000054267.22	.	BCM	GRCh38.p13	chr1	235255715	235255715	+	A	A	G	Silent	SNP	ENST00000264183.9	exon5	c.T219C	p.G73G	exonic	ENSG00000054267.22	.	synonymous SNV	ENSG00000054267.22:ENST00000264183.9:exon5:c.T219C:p.G73G	1q42.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARID4B	187	0	161	16	0.0903954802259887	TRUE	TRUE
ENSG00000115593.15	.	BCM	GRCh38.p13	chr2	88087937	88087937	+	C	C	T	Silent	SNP	ENST00000419482.7	exon3	c.C390T	p.D130D	exonic	ENSG00000115593.15	.	synonymous SNV	ENSG00000115593.15:ENST00000419482.7:exon3:c.C390T:p.D130D	2p11.2	C3L-03123	2.501e-05	0	0.0002	0	0	0	0	6.153e-05	rs771497079	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV70225065;OCCURENCE=1(biliary_tract),1(prostate),1(endometrium)	SMYD1	200	1	202	59	0.226053639846743	TRUE	TRUE
ENSG00000135968.21	.	BCM	GRCh38.p13	chr2	108452421	108452421	+	A	A	G	Silent	SNP	ENST00000309863.11	exon4	c.A171G	p.E57E	exonic	ENSG00000135968.21	.	synonymous SNV	ENSG00000135968.21:ENST00000309863.11:exon4:c.A171G:p.E57E	2q12.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GCC2	229	0	210	72	0.25531914893617	TRUE	TRUE
ENSG00000196834.12	.	BCM	GRCh38.p13	chr2	130508873	130508873	+	T	T	C	Silent	SNP	ENST00000451531.6	exon1	c.A363G	p.G121G	exonic	ENSG00000196834.12	.	synonymous SNV	ENSG00000196834.12:ENST00000451531.6:exon1:c.A363G:p.G121G	2q21.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	POTEI	380	1	314	93	0.228501228501229	NA	TRUE
ENSG00000183091.19	.	BCM	GRCh38.p13	chr2	151506909	151506909	+	C	C	T	Silent	SNP	ENST00000172853.14	exon135	c.G18453A	p.S6151S	exonic	ENSG00000183091.19	.	synonymous SNV	ENSG00000183091.19:ENST00000172853.14:exon135:c.G18453A:p.S6151S	2q23.3	C3L-03123	8.352e-06	0.0001	0	0	0	0	0	0	rs769787871	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51083619;OCCURENCE=1(large_intestine),1(upper_aerodigestive_tract)	NEB	270	0	227	66	0.225255972696246	TRUE	TRUE
ENSG00000115183.15	.	BCM	GRCh38.p13	chr2	159179131	159179131	+	C	C	T	Silent	SNP	ENST00000263635.8	exon14	c.C2478T	p.D826D	exonic	ENSG00000115183.15	.	synonymous SNV	ENSG00000115183.15:ENST00000263635.8:exon14:c.C2478T:p.D826D	2q24.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TANC1	133	0	159	45	0.220588235294118	TRUE	NA
ENSG00000155760.2	.	BCM	GRCh38.p13	chr2	202035367	202035367	+	C	C	T	Silent	SNP	ENST00000286201.2	exon1	c.C720T	p.N240N	exonic	ENSG00000155760.2	.	synonymous SNV	ENSG00000155760.2:ENST00000286201.2:exon1:c.C720T:p.N240N	2q33.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53808472;OCCURENCE=1(large_intestine),1(stomach)	FZD7	279	0	401	46	0.102908277404922	TRUE	TRUE
ENSG00000123977.10	.	BCM	GRCh38.p13	chr2	227893867	227893867	+	G	G	A	Silent	SNP	ENST00000309931.3	exon5	c.G390A	p.L130L	exonic	ENSG00000123977.10	.	synonymous SNV	ENSG00000123977.10:ENST00000309931.3:exon5:c.G390A:p.L130L	2q36.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DAW1	237	0	285	29	0.0923566878980892	TRUE	TRUE
ENSG00000173692.13	.	BCM	GRCh38.p13	chr2	231072401	231072401	+	A	A	G	Silent	SNP	ENST00000308696.11	exon7	c.A867G	p.G289G	exonic	ENSG00000173692.13	.	synonymous SNV	ENSG00000173692.13:ENST00000308696.11:exon7:c.A867G:p.G289G	2q37.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PSMD1	399	0	482	41	0.0783938814531549	TRUE	TRUE
ENSG00000150995.19	.	BCM	GRCh38.p13	chr3	4783872	4783872	+	C	C	T	Silent	SNP	ENST00000649015.1	exon51	c.C6567T	p.D2189D	exonic	ENSG00000150995.19	.	synonymous SNV	ENSG00000150995.19:ENST00000649015.1:exon51:c.C6567T:p.D2189D	3p26.1	C3L-03123	6.392e-05	0.0003	0	0.0004	0	2.261e-05	0	0	rs578051224	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56990162;OCCURENCE=1(large_intestine),1(endometrium)	ITPR1	118	1	161	14	0.08	TRUE	TRUE
ENSG00000170876.8	.	BCM	GRCh38.p13	chr3	14134849	14134849	+	T	T	C	Silent	SNP	ENST00000306077.5	exon8	c.T663C	p.R221R	exonic	ENSG00000170876.8	.	synonymous SNV	ENSG00000170876.8:ENST00000306077.5:exon8:c.T663C:p.R221R	3p25.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM43	347	0	356	47	0.116625310173697	TRUE	TRUE
ENSG00000164080.13	.	BCM	GRCh38.p13	chr3	51633729	51633729	+	G	G	A	Silent	SNP	ENST00000409535.6	exon7	c.G978A	p.T326T	exonic	ENSG00000164080.13	.	synonymous SNV	ENSG00000164080.13:ENST00000409535.6:exon7:c.G978A:p.T326T	3p21.2	C3L-03123	6.592e-05	0.0004	0	0.0002	0	2.998e-05	0	0	rs753671462	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAD54L2	220	1	237	24	0.0919540229885057	TRUE	NA
ENSG00000157445.15	.	BCM	GRCh38.p13	chr3	54569960	54569960	+	C	C	T	Silent	SNP	ENST00000474759.6	exon8	c.C744T	p.I248I	exonic	ENSG00000157445.15	.	synonymous SNV	ENSG00000157445.15:ENST00000474759.6:exon8:c.C744T:p.I248I	3p14.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNA2D3	183	1	185	26	0.123222748815166	TRUE	TRUE
ENSG00000031081.11	.	BCM	GRCh38.p13	chr3	119413942	119413942	+	G	G	A	Silent	SNP	ENST00000264245.9	exon12	c.G2013A	p.S671S	exonic	ENSG00000031081.11	.	synonymous SNV	ENSG00000031081.11:ENST00000264245.9:exon12:c.G2013A:p.S671S	3q13.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51789399;OCCURENCE=1(stomach),1(endometrium)	ARHGAP31	412	0	450	51	0.101796407185629	TRUE	TRUE
ENSG00000152977.10	.	BCM	GRCh38.p13	chr3	147410151	147410151	+	C	C	T	Silent	SNP	ENST00000282928.5	exon1	c.C39T	p.G13G	exonic	ENSG00000152977.10	.	synonymous SNV	ENSG00000152977.10:ENST00000282928.5:exon1:c.C39T:p.G13G	3q24	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZIC1	171	0	230	24	0.094488188976378	TRUE	TRUE
ENSG00000078177.14	.	BCM	GRCh38.p13	chr4	40102115	40102115	+	T	T	A	Silent	SNP	ENST00000261435.11	exon4	c.T270A	p.T90T	exonic	ENSG00000078177.14	.	synonymous SNV	ENSG00000078177.14:ENST00000261435.11:exon4:c.T270A:p.T90T	4p14	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	N4BP2	89	0	96	8	0.0769230769230769	TRUE	TRUE
ENSG00000151834.15	.	BCM	GRCh38.p13	chr4	46305695	46305695	+	T	T	C	Silent	SNP	ENST00000510861.5	exon7	c.A576G	p.S192S	exonic	ENSG00000151834.15	.	synonymous SNV	ENSG00000151834.15:ENST00000510861.5:exon7:c.A576G:p.S192S	4p12	C3L-03123	8.278e-06	0	0	0	0	1.507e-05	0	0	rs200053930	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GABRA2	143	0	181	18	0.0904522613065327	TRUE	NA
ENSG00000138801.9	.	BCM	GRCh38.p13	chr4	107693822	107693822	+	A	A	G	Silent	SNP	ENST00000265174.5	exon3	c.T360C	p.F120F	exonic	ENSG00000138801.9	.	synonymous SNV	ENSG00000138801.9:ENST00000265174.5:exon3:c.T360C:p.F120F	4q25	C3L-03123	1.651e-05	0	8.741e-05	0	0	1.501e-05	0	0	rs375007289	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PAPSS1	405	0	447	52	0.104208416833667	TRUE	NA
ENSG00000138650.9	.	BCM	GRCh38.p13	chr4	133150737	133150737	+	C	C	T	Silent	SNP	ENST00000264360.7	exon1	c.C597T	p.Y199Y	exonic	ENSG00000138650.9	.	synonymous SNV	ENSG00000138650.9:ENST00000264360.7:exon1:c.C597T:p.Y199Y	4q28.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDH10	155	0	164	17	0.0939226519337017	TRUE	TRUE
ENSG00000121210.16	.	BCM	GRCh38.p13	chr4	153598704	153598704	+	C	C	T	Silent	SNP	ENST00000409663.7	exon21	c.C2235T	p.P745P	exonic	ENSG00000121210.16	.	synonymous SNV	ENSG00000121210.16:ENST00000409663.7:exon21:c.C2235T:p.P745P	4q31.3	C3L-03123	9.082e-05	0.0004	0.0003	0	0	3.004e-05	0	0.0001	rs200199904	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM131L	224	0	232	40	0.147058823529412	TRUE	NA
ENSG00000113504.21	.	BCM	GRCh38.p13	chr5	1086981	1086981	+	G	G	A	Silent	SNP	ENST00000264930.10	exon6	c.C597T	p.G199G	exonic	ENSG00000113504.21	.	synonymous SNV	ENSG00000113504.21:ENST00000264930.10:exon6:c.C597T:p.G199G	5p15.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC12A7	376	1	433	55	0.112704918032787	TRUE	TRUE
ENSG00000170549.4	.	BCM	GRCh38.p13	chr5	3599735	3599735	+	C	C	A	Silent	SNP	ENST00000302006.4	exon2	c.C787A	p.R263R	exonic	ENSG00000170549.4	.	synonymous SNV	ENSG00000170549.4:ENST00000302006.4:exon2:c.C787A:p.R263R	5p15.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IRX1	242	0	284	35	0.109717868338558	TRUE	TRUE
ENSG00000112902.12	.	BCM	GRCh38.p13	chr5	9062963	9062963	+	G	G	A	Silent	SNP	ENST00000382496.10	exon18	c.C2442T	p.P814P	exonic	ENSG00000112902.12	.	synonymous SNV	ENSG00000112902.12:ENST00000382496.10:exon18:c.C2442T:p.P814P	5p15.31	C3L-03123	2.472e-05	0	8.642e-05	0.0001	0	1.499e-05	0	0	rs769162684	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66803970;OCCURENCE=1(lung)	SEMA5A	643	0	676	69	0.0926174496644295	TRUE	TRUE
ENSG00000164190.19	.	BCM	GRCh38.p13	chr5	37020548	37020548	+	A	A	G	Silent	SNP	ENST00000282516.13	exon26	c.A5100G	p.S1700S	exonic	ENSG00000164190.19	.	synonymous SNV	ENSG00000164190.19:ENST00000282516.13:exon26:c.A5100G:p.S1700S	5p13.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NIPBL	426	0	452	52	0.103174603174603	TRUE	NA
ENSG00000095015.6	.	BCM	GRCh38.p13	chr5	56882809	56882809	+	C	C	T	Silent	SNP	ENST00000399503.4	exon14	c.C3609T	p.P1203P	exonic	ENSG00000095015.6	.	synonymous SNV	ENSG00000095015.6:ENST00000399503.4:exon14:c.C3609T:p.P1203P	5q11.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP3K1	94	0	107	12	0.100840336134454	TRUE	TRUE
ENSG00000094880.11	.	BCM	GRCh38.p13	chr5	138213160	138213160	+	A	A	G	Silent	SNP	ENST00000394886.7	exon1	c.T153C	p.S51S	exonic	ENSG00000094880.11	.	synonymous SNV	ENSG00000094880.11:ENST00000394886.7:exon1:c.T153C:p.S51S	5q31.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDC23	209	0	288	51	0.150442477876106	TRUE	TRUE
ENSG00000081842.18	.	BCM	GRCh38.p13	chr5	140829978	140829978	+	C	C	T	Silent	SNP	ENST00000529310.6	exon1	c.C1887T	p.G629G	exonic	ENSG00000081842.18	.	synonymous SNV	ENSG00000081842.18:ENST00000529310.6:exon1:c.C1887T:p.G629G	5q31.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHA6	604	0	645	85	0.116438356164384	NA	TRUE
ENSG00000133706.19	.	BCM	GRCh38.p13	chr5	146133053	146133053	+	A	A	G	Silent	SNP	ENST00000394434.7	exon23	c.T2241C	p.G747G	exonic	ENSG00000133706.19	.	synonymous SNV	ENSG00000133706.19:ENST00000394434.7:exon23:c.T2241C:p.G747G	5q32	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LARS1	265	0	283	26	0.0841423948220065	TRUE	TRUE
ENSG00000113649.11	.	BCM	GRCh38.p13	chr5	146459144	146459144	+	A	A	C	Silent	SNP	ENST00000296702.9	exon4	c.A699C	p.A233A	exonic	ENSG00000113649.11	.	synonymous SNV	ENSG00000113649.11:ENST00000296702.9:exon4:c.A699C:p.A233A	5q32	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TCERG1	1060	2	1113	130	0.104585679806919	TRUE	NA
ENSG00000113649.11	.	BCM	GRCh38.p13	chr5	146459147	146459147	+	A	A	G	Silent	SNP	ENST00000296702.9	exon4	c.A702G	p.Q234Q	exonic	ENSG00000113649.11	.	synonymous SNV	ENSG00000113649.11:ENST00000296702.9:exon4:c.A702G:p.Q234Q	5q32	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57042834;OCCURENCE=1(liver)	TCERG1	1142	8	1211	144	0.106273062730627	TRUE	TRUE
ENSG00000055163.20	.	BCM	GRCh38.p13	chr5	157324004	157324004	+	A	A	G	Silent	SNP	ENST00000616178.4	exon17	c.A1830G	p.G610G	exonic	ENSG00000055163.20	.	synonymous SNV	ENSG00000055163.20:ENST00000616178.4:exon17:c.A1830G:p.G610G	5q33.3	C3L-03123	0.0006	0.0064	0.0005	0	0	6.898e-05	0.0026	0	rs142973944	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CYFIP2	272	0	291	27	0.0849056603773585	TRUE	NA
ENSG00000197226.12	.	BCM	GRCh38.p13	chr5	179863685	179863685	+	G	G	A	Silent	SNP	ENST00000356834.7	exon22	c.C3516T	p.D1172D	exonic	ENSG00000197226.12	.	synonymous SNV	ENSG00000197226.12:ENST00000356834.7:exon22:c.C3516T:p.D1172D	5q35.3	C3L-03123	1.654e-05	0	0	0	0	1.507e-05	0	6.057e-05	rs755536613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52971691;OCCURENCE=1(biliary_tract)	TBC1D9B	379	0	463	73	0.136194029850746	TRUE	TRUE
ENSG00000197226.12	.	BCM	GRCh38.p13	chr5	179863715	179863715	+	C	C	T	Silent	SNP	ENST00000356834.7	exon22	c.G3486A	p.T1162T	exonic	ENSG00000197226.12	.	synonymous SNV	ENSG00000197226.12:ENST00000356834.7:exon22:c.G3486A:p.T1162T	5q35.3	C3L-03123	0.0001	0	8.645e-05	0	0.0009	7.532e-05	0.0011	0	rs760539290	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99481797;OCCURENCE=1(large_intestine)	TBC1D9B	422	0	552	82	0.129337539432177	TRUE	NA
ENSG00000096696.14	.	BCM	GRCh38.p13	chr6	7565448	7565448	+	C	C	T	Silent	SNP	ENST00000379802.8	exon7	c.C867T	p.C289C	exonic	ENSG00000096696.14	.	synonymous SNV	ENSG00000096696.14:ENST00000379802.8:exon7:c.C867T:p.C289C	6p24.3	C3L-03123	8.239e-06	0	0	0	0	1.499e-05	0	0	rs397516973	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101131207;OCCURENCE=1(urinary_tract)	DSP	530	0	581	62	0.0964230171073095	TRUE	NA
ENSG00000096433.11	.	BCM	GRCh38.p13	chr6	33677026	33677026	+	C	C	T	Silent	SNP	ENST00000605930.3	exon27	c.C3459T	p.D1153D	exonic	ENSG00000096433.11	.	synonymous SNV	ENSG00000096433.11:ENST00000605930.3:exon27:c.C3459T:p.D1153D	6p21.31	C3L-03123	3.31e-05	0	0	0.0002	0	3.012e-05	0	0	rs377753110	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65408352;OCCURENCE=1(large_intestine)	ITPR3	215	0	289	30	0.0940438871473354	TRUE	TRUE
ENSG00000096060.14	.	BCM	GRCh38.p13	chr6	35637018	35637018	+	G	G	A	Silent	SNP	ENST00000536438.5	exon4	c.C246T	p.G82G	exonic	ENSG00000096060.14	.	synonymous SNV	ENSG00000096060.14:ENST00000536438.5:exon4:c.C246T:p.G82G	6p21.31	C3L-03123	8.481e-06	0	0	0	0	1.551e-05	0	0	rs749128269	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FKBP5	126	0	144	11	0.0709677419354839	TRUE	NA
ENSG00000124608.5	.	BCM	GRCh38.p13	chr6	44313318	44313318	+	T	T	C	Silent	SNP	ENST00000244571.5	exon1	c.A6G	p.A2A	exonic	ENSG00000124608.5	.	synonymous SNV	ENSG00000124608.5:ENST00000244571.5:exon1:c.A6G:p.A2A	6p21.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AARS2	579	0	614	71	0.103649635036496	TRUE	NA
ENSG00000188107.15	.	BCM	GRCh38.p13	chr6	64230808	64230808	+	G	G	A	Silent	SNP	ENST00000370621.7	exon31	c.C6208T	p.L2070L	exonic	ENSG00000188107.15	.	synonymous SNV	ENSG00000188107.15:ENST00000370621.7:exon31:c.C6208T:p.L2070L	6q12	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EYS	196	1	156	21	0.11864406779661	TRUE	TRUE
ENSG00000112379.9	.	BCM	GRCh38.p13	chr6	138291931	138291931	+	G	G	A	Silent	SNP	ENST00000251691.5	exon19	c.G3246A	p.L1082L	exonic	ENSG00000112379.9	.	synonymous SNV	ENSG00000112379.9:ENST00000251691.5:exon19:c.G3246A:p.L1082L	6q23.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARFGEF3	79	0	115	8	0.0650406504065041	TRUE	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152433879	152433879	+	G	G	A	Silent	SNP	ENST00000367255.10	exon34	c.C4377T	p.S1459S	exonic	ENSG00000131018.24	.	synonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon34:c.C4377T:p.S1459S	6q25.2	C3L-03123	6.615e-05	0	0	0	0	9.02e-05	0	0.0001	rs146567226	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV104543098;OCCURENCE=1(large_intestine)	SYNE1	345	0	359	42	0.104738154613466	TRUE	NA
ENSG00000106066.15	.	BCM	GRCh38.p13	chr7	29064087	29064087	+	A	A	G	Silent	SNP	ENST00000265394.10	exon11	c.T1111C	p.L371L	exonic	ENSG00000106066.15	.	synonymous SNV	ENSG00000106066.15:ENST00000265394.10:exon11:c.T1111C:p.L371L	7p14.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPVL	261	1	318	39	0.109243697478992	TRUE	TRUE
ENSG00000234444.10	.	BCM	GRCh38.p13	chr7	64336922	64336922	+	C	C	T	Silent	SNP	ENST00000423484.3	exon3	c.C166T	p.L56L	exonic	ENSG00000234444.10	.	synonymous SNV	ENSG00000234444.10:ENST00000423484.3:exon3:c.C166T:p.L56L	7q11.21	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF736	520	1	541	71	0.116013071895425	NA	TRUE
ENSG00000066923.17	.	BCM	GRCh38.p13	chr7	100198150	100198150	+	C	C	T	Silent	SNP	ENST00000426455.5	exon12	c.C1228T	p.L410L	exonic	ENSG00000066923.17	.	synonymous SNV	ENSG00000066923.17:ENST00000426455.5:exon12:c.C1228T:p.L410L	7q22.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STAG3	646	1	741	78	0.0952380952380952	NA	TRUE
ENSG00000146842.17	.	BCM	GRCh38.p13	chr7	130184205	130184205	+	T	T	C	Silent	SNP	ENST00000397622.7	exon8	c.A1002G	p.S334S	exonic	ENSG00000146842.17	.	synonymous SNV	ENSG00000146842.17:ENST00000397622.7:exon8:c.A1002G:p.S334S	7q32.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM209	152	0	153	23	0.130681818181818	TRUE	TRUE
ENSG00000128567.17	.	BCM	GRCh38.p13	chr7	131510952	131510952	+	C	C	T	Silent	SNP	ENST00000378555.8	exon2	c.G582A	p.S194S	exonic	ENSG00000128567.17	.	synonymous SNV	ENSG00000128567.17:ENST00000378555.8:exon2:c.G582A:p.S194S	7q32.3	C3L-03123	8.238e-06	9.61e-05	0	0	0	0	0	0	rs774359433	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PODXL	498	0	628	81	0.114245416078984	TRUE	NA
ENSG00000221970.2	.	BCM	GRCh38.p13	chr7	144318400	144318400	+	C	C	A	Silent	SNP	ENST00000641044.1	exon2	c.C276A	p.S92S	exonic	ENSG00000221970.2	.	synonymous SNV	ENSG00000221970.2:ENST00000641044.1:exon2:c.C276A:p.S92S	7q35	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR2A1	1367	0	1381	111	0.0743967828418231	NA	TRUE
ENSG00000158863.22	.	BCM	GRCh38.p13	chr8	22102602	22102602	+	G	G	A	Silent	SNP	ENST00000289921.8	exon16	c.G2067A	p.Q689Q	exonic	ENSG00000158863.22	.	synonymous SNV	ENSG00000158863.22:ENST00000289921.8:exon16:c.G2067A:p.Q689Q	8p21.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM160B2	331	0	369	52	0.123515439429929	TRUE	NA
ENSG00000175305.17	.	BCM	GRCh38.p13	chr8	94892889	94892889	+	A	A	G	Silent	SNP	ENST00000520509.5	exon5	c.T246C	p.S82S	exonic	ENSG00000175305.17	.	synonymous SNV	ENSG00000175305.17:ENST00000520509.5:exon5:c.T246C:p.S82S	8q22.1	C3L-03123	8.29e-06	9.96e-05	0	0	0	0	0	0	rs142239101	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCNE2	158	0	192	20	0.0943396226415094	TRUE	NA
ENSG00000169946.14	.	BCM	GRCh38.p13	chr8	105801468	105801468	+	A	A	G	Silent	SNP	ENST00000407775.7	exon8	c.A1386G	p.K462K	exonic	ENSG00000169946.14	.	synonymous SNV	ENSG00000169946.14:ENST00000407775.7:exon8:c.A1386G:p.K462K	8q23.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFPM2	830	0	866	111	0.113613101330604	TRUE	TRUE
ENSG00000178209.15	.	BCM	GRCh38.p13	chr8	143919441	143919441	+	G	G	A	Silent	SNP	ENST00000322810.8	exon32	c.C10791T	p.H3597H	exonic	ENSG00000178209.15	.	synonymous SNV	ENSG00000178209.15:ENST00000322810.8:exon32:c.C10791T:p.H3597H	8q24.3	C3L-03123	7.539e-05	0.0003	0	0.0002	0	4.548e-05	0	6.089e-05	rs371407635	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59691323;OCCURENCE=1(large_intestine),1(stomach)	PLEC	264	0	339	38	0.10079575596817	TRUE	TRUE
ENSG00000205808.7	.	BCM	GRCh38.p13	chr9	4662474	4662474	+	C	C	T	Silent	SNP	ENST00000381883.5	exon1	c.C99T	p.G33G	exonic	ENSG00000205808.7	.	synonymous SNV	ENSG00000205808.7:ENST00000381883.5:exon1:c.C99T:p.G33G	9p24.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLPP6	348	3	309	66	0.176	TRUE	NA
ENSG00000086065.14	.	BCM	GRCh38.p13	chr9	33266018	33266018	+	T	T	C	Silent	SNP	ENST00000223500.9	exon2	c.T78C	p.S26S	exonic	ENSG00000086065.14	.	synonymous SNV	ENSG00000086065.14:ENST00000223500.9:exon2:c.T78C:p.S26S	9p13.3	C3L-03123	.	.	.	.	.	.	.	.	rs1023861534	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHMP5	114	0	150	12	0.0740740740740741	TRUE	NA
ENSG00000122733.12	.	BCM	GRCh38.p13	chr9	34977094	34977094	+	G	G	A	Silent	SNP	ENST00000242315.3	exon6	c.G861A	p.L287L	exonic	ENSG00000122733.12	.	synonymous SNV	ENSG00000122733.12:ENST00000242315.3:exon6:c.G861A:p.L287L	9p13.3	C3L-03123	8.603e-06	0	0	0	0	0	0.0012	0	rs764545031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PHF24	120	0	153	13	0.0783132530120482	TRUE	NA
ENSG00000136783.10	.	BCM	GRCh38.p13	chr9	104753033	104753033	+	A	A	G	Silent	SNP	ENST00000374767.5	exon3	c.A399G	p.P133P	exonic	ENSG00000136783.10	.	synonymous SNV	ENSG00000136783.10:ENST00000374767.5:exon3:c.A399G:p.P133P	9q31.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NIPSNAP3A	319	1	349	51	0.1275	TRUE	TRUE
ENSG00000119396.11	.	BCM	GRCh38.p13	chr9	121190655	121190655	+	T	T	C	Silent	SNP	ENST00000373840.9	exon4	c.A183G	p.K61K	exonic	ENSG00000119396.11	.	synonymous SNV	ENSG00000119396.11:ENST00000373840.9:exon4:c.A183G:p.K61K	9q33.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAB14	381	0	395	56	0.124168514412417	TRUE	TRUE
ENSG00000130635.16	.	BCM	GRCh38.p13	chr9	134814817	134814817	+	A	A	C	Silent	SNP	ENST00000371817.8	exon50	c.A3927C	p.G1309G	exonic	ENSG00000130635.16	.	synonymous SNV	ENSG00000130635.16:ENST00000371817.8:exon50:c.A3927C:p.G1309G	9q34.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL5A1	241	0	339	24	0.0661157024793388	TRUE	TRUE
ENSG00000165731.20	.	BCM	GRCh38.p13	chr10	43116673	43116673	+	G	G	A	Silent	SNP	ENST00000355710.8	exon12	c.G2226A	p.T742T	exonic	ENSG00000165731.20	.	synonymous SNV	ENSG00000165731.20:ENST00000355710.8:exon12:c.G2226A:p.T742T	10q11.21	C3L-03123	0.0002	0	0	0	0	4.495e-05	0	0.0015	rs762876946	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100394888;OCCURENCE=1(upper_aerodigestive_tract)	RET	341	0	407	59	0.126609442060086	TRUE	NA
ENSG00000172538.7	.	BCM	GRCh38.p13	chr10	49132330	49132330	+	C	C	T	Silent	SNP	ENST00000311787.6	exon2	c.G135A	p.S45S	exonic	ENSG00000172538.7	.	synonymous SNV	ENSG00000172538.7:ENST00000311787.6:exon2:c.G135A:p.S45S	10q11.23	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM170B	114	0	103	12	0.104347826086957	TRUE	TRUE
ENSG00000138182.14	.	BCM	GRCh38.p13	chr10	89758729	89758729	+	A	A	T	Silent	SNP	ENST00000371728.7	exon27	c.A4527T	p.T1509T	exonic	ENSG00000138182.14	.	synonymous SNV	ENSG00000138182.14:ENST00000371728.7:exon27:c.A4527T:p.T1509T	10q23.31	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIF20B	137	0	144	20	0.121951219512195	TRUE	TRUE
ENSG00000119969.15	.	BCM	GRCh38.p13	chr10	94574178	94574178	+	A	A	G	Silent	SNP	ENST00000348459.10	exon8	c.A696G	p.E232E	exonic	ENSG00000119969.15	.	synonymous SNV	ENSG00000119969.15:ENST00000348459.10:exon8:c.A696G:p.E232E	10q23.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HELLS	198	0	222	17	0.0711297071129707	TRUE	TRUE
ENSG00000165863.17	.	BCM	GRCh38.p13	chr10	116665669	116665669	+	G	G	A	Silent	SNP	ENST00000588184.2	exon3	c.C213T	p.S71S	exonic	ENSG00000165863.17	.	synonymous SNV	ENSG00000165863.17:ENST00000588184.2:exon3:c.C213T:p.S71S	10q25.3	C3L-03123	2.473e-05	0.0003	0	0	0	0	0	0	rs374577819	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65024708;OCCURENCE=1(skin)	C10orf82	190	0	211	31	0.128099173553719	TRUE	TRUE
ENSG00000198873.12	.	BCM	GRCh38.p13	chr10	119436788	119436788	+	G	G	A	Silent	SNP	ENST00000392870.3	exon9	c.G876A	p.A292A	exonic	ENSG00000198873.12	.	synonymous SNV	ENSG00000198873.12:ENST00000392870.3:exon9:c.G876A:p.A292A	10q26.11	C3L-03123	6.652e-05	0	0.0004	0.0001	0	3.019e-05	0	0	rs764564796	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GRK5	165	0	152	27	0.150837988826816	TRUE	NA
ENSG00000214279.13	.	BCM	GRCh38.p13	chr10	133459533	133459533	+	C	C	T	Silent	SNP	ENST00000640237.1	exon6	c.C1332T	p.D444D	exonic	ENSG00000214279.13	.	synonymous SNV	ENSG00000214279.13:ENST00000640237.1:exon6:c.C1332T:p.D444D	10q26.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCART1	99	0	121	14	0.103703703703704	TRUE	NA
ENSG00000206013.2	.	BCM	GRCh38.p13	chr11	299404	299404	+	C	C	T	Silent	SNP	ENST00000382614.2	exon1	c.G87A	p.P29P	exonic	ENSG00000206013.2	.	synonymous SNV	ENSG00000206013.2:ENST00000382614.2:exon1:c.G87A:p.P29P	11p15.5	C3L-03123	0.0018	0	0.0012	0.0007	0	0.0009	0.0037	0.0059	rs372443030	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66888507;OCCURENCE=2(central_nervous_system),1(haematopoietic_and_lymphoid_tissue),1(soft_tissue)	IFITM5	115	0	158	13	0.0760233918128655	TRUE	NA
ENSG00000110628.16	.	BCM	GRCh38.p13	chr11	2909250	2909250	+	C	C	A	Silent	SNP	ENST00000649076.2	exon4	c.C297A	p.A99A	exonic	ENSG00000110628.16	.	synonymous SNV	ENSG00000110628.16:ENST00000649076.2:exon4:c.C297A:p.A99A	11p15.4	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC22A18	341	0	433	38	0.0806794055201698	TRUE	TRUE
ENSG00000166833.21	.	BCM	GRCh38.p13	chr11	19879999	19879999	+	C	C	T	Silent	SNP	ENST00000396087.7	exon5	c.C642T	p.A214A	exonic	ENSG00000166833.21	.	synonymous SNV	ENSG00000166833.21:ENST00000396087.7:exon5:c.C642T:p.A214A	11p15.1	C3L-03123	7.583e-05	0	0	0	0	1.541e-05	0	0.0005	rs764794415	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NAV2	389	0	522	33	0.0594594594594595	TRUE	NA
ENSG00000197901.11	.	BCM	GRCh38.p13	chr11	62983580	62983580	+	C	C	T	Silent	SNP	ENST00000377871.7	exon3	c.G585A	p.S195S	exonic	ENSG00000197901.11	.	synonymous SNV	ENSG00000197901.11:ENST00000377871.7:exon3:c.G585A:p.S195S	11q12.3	C3L-03123	6.378e-05	0	0	0	0	0.0001	0	0	rs778657112	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC22A6	369	0	453	29	0.0601659751037344	TRUE	NA
ENSG00000118369.13	.	BCM	GRCh38.p13	chr11	78196869	78196869	+	C	C	T	Silent	SNP	ENST00000529308.6	exon2	c.C624T	p.A208A	exonic	ENSG00000118369.13	.	synonymous SNV	ENSG00000118369.13:ENST00000529308.6:exon2:c.C624T:p.A208A	11q14.1	C3L-03123	0	0	0	0	0	0	0	0	rs750266219	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	USP35	150	0	138	12	0.08	TRUE	NA
ENSG00000149256.16	.	BCM	GRCh38.p13	chr11	78729611	78729611	+	G	G	A	Silent	SNP	ENST00000278550.12	exon22	c.C3171T	p.C1057C	exonic	ENSG00000149256.16	.	synonymous SNV	ENSG00000149256.16:ENST00000278550.12:exon22:c.C3171T:p.C1057C	11q14.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TENM4	144	0	136	10	0.0684931506849315	TRUE	NA
ENSG00000168959.14	.	BCM	GRCh38.p13	chr11	88509300	88509300	+	C	C	T	Silent	SNP	ENST00000305447.4	exon9	c.G2931A	p.T977T	exonic	ENSG00000168959.14	.	synonymous SNV	ENSG00000168959.14:ENST00000305447.4:exon9:c.G2931A:p.T977T	11q14.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GRM5	418	0	318	36	0.101694915254237	TRUE	TRUE
ENSG00000110400.11	.	BCM	GRCh38.p13	chr11	119665029	119665029	+	G	G	A	Silent	SNP	ENST00000264025.8	exon6	c.C1272T	p.D424D	exonic	ENSG00000110400.11	.	synonymous SNV	ENSG00000110400.11:ENST00000264025.8:exon6:c.C1272T:p.D424D	11q23.3	C3L-03123	4.231e-05	0	0	0.0004	0	1.55e-05	0	6.066e-05	rs200452076	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NECTIN1	420	0	476	40	0.0775193798449612	TRUE	NA
ENSG00000080854.15	.	BCM	GRCh38.p13	chr11	133919813	133919813	+	C	C	T	Silent	SNP	ENST00000321016.12	exon18	c.G3912A	p.T1304T	exonic	ENSG00000080854.15	.	synonymous SNV	ENSG00000080854.15:ENST00000321016.12:exon18:c.G3912A:p.T1304T	11q25	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58065150;OCCURENCE=3(large_intestine),1(stomach)	IGSF9B	9	0	21	3	0.125	TRUE	TRUE
ENSG00000080854.15	.	BCM	GRCh38.p13	chr11	133925919	133925919	+	C	C	T	Silent	SNP	ENST00000321016.12	exon14	c.G1854A	p.P618P	exonic	ENSG00000080854.15	.	synonymous SNV	ENSG00000080854.15:ENST00000321016.12:exon14:c.G1854A:p.P618P	11q25	C3L-03123	.	.	.	.	.	.	.	.	rs936155611	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGSF9B	524	0	526	72	0.120401337792642	TRUE	NA
ENSG00000118972.3	.	BCM	GRCh38.p13	chr12	4379541	4379541	+	G	G	A	Silent	SNP	ENST00000237837.2	exon1	c.C42T	p.C14C	exonic	ENSG00000118972.3	.	synonymous SNV	ENSG00000118972.3:ENST00000237837.2:exon1:c.C42T:p.C14C	12p13.32	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FGF23	541	0	603	84	0.122270742358079	TRUE	TRUE
ENSG00000067182.8	.	BCM	GRCh38.p13	chr12	6329803	6329803	+	G	G	A	Silent	SNP	ENST00000162749.7	exon9	c.C1032T	p.S344S	exonic	ENSG00000067182.8	.	synonymous SNV	ENSG00000067182.8:ENST00000162749.7:exon9:c.C1032T:p.S344S	12p13.31	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TNFRSF1A	181	0	255	17	0.0625	TRUE	TRUE
ENSG00000123066.8	.	BCM	GRCh38.p13	chr12	115975190	115975190	+	A	A	G	Silent	SNP	ENST00000281928.8	exon25	c.T5712C	p.L1904L	exonic	ENSG00000123066.8	.	synonymous SNV	ENSG00000123066.8:ENST00000281928.8:exon25:c.T5712C:p.L1904L	12q24.21	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MED13L	674	0	612	143	0.189403973509934	TRUE	TRUE
ENSG00000197653.16	.	BCM	GRCh38.p13	chr12	123871563	123871563	+	T	T	C	Silent	SNP	ENST00000638045.1	exon44	c.T7392C	p.T2464T	exonic	ENSG00000197653.16	.	synonymous SNV	ENSG00000197653.16:ENST00000638045.1:exon44:c.T7392C:p.T2464T	12q24.31	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH10	277	0	280	22	0.0728476821192053	TRUE	TRUE
ENSG00000213995.11	.	BCM	GRCh38.p13	chr13	110615758	110615758	+	G	G	A	Silent	SNP	ENST00000309957.2	exon1	c.G84A	p.G28G	exonic	ENSG00000213995.11	.	synonymous SNV	ENSG00000213995.11:ENST00000309957.2:exon1:c.G84A:p.G28G	13q34	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100010719;OCCURENCE=1(endometrium)	NAXD	127	0	136	22	0.139240506329114	TRUE	TRUE
ENSG00000153531.13	.	BCM	GRCh38.p13	chr13	113453402	113453402	+	G	G	A	Silent	SNP	ENST00000375418.7	exon1	c.C36T	p.S12S	exonic	ENSG00000153531.13	.	synonymous SNV	ENSG00000153531.13:ENST00000375418.7:exon1:c.C36T:p.S12S	13q34	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADPRHL1	426	0	449	61	0.119607843137255	TRUE	NA
ENSG00000100813.14	.	BCM	GRCh38.p13	chr14	23081748	23081748	+	C	C	T	Silent	SNP	ENST00000262710.5	exon5	c.G699A	p.Q233Q	exonic	ENSG00000100813.14	.	synonymous SNV	ENSG00000100813.14:ENST00000262710.5:exon5:c.G699A:p.Q233Q	14q11.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ACIN1	175	0	217	13	0.0565217391304348	TRUE	TRUE
ENSG00000092009.10	.	BCM	GRCh38.p13	chr14	24506262	24506262	+	C	C	T	Silent	SNP	ENST00000250378.7	exon4	c.G366A	p.L122L	exonic	ENSG00000092009.10	.	synonymous SNV	ENSG00000092009.10:ENST00000250378.7:exon4:c.G366A:p.L122L	14q12	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CMA1	234	0	224	58	0.205673758865248	TRUE	TRUE
ENSG00000054654.18	.	BCM	GRCh38.p13	chr14	63909193	63909193	+	C	C	A	Silent	SNP	ENST00000344113.8	exon2	c.C45A	p.S15S	exonic	ENSG00000054654.18	.	synonymous SNV	ENSG00000054654.18:ENST00000344113.8:exon2:c.C45A:p.S15S	14q23.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SYNE2	227	0	217	44	0.168582375478927	TRUE	TRUE
ENSG00000184507.16	.	BCM	GRCh38.p13	chr15	34357218	34357218	+	C	C	A	Silent	SNP	ENST00000614490.4	exon8	c.C3126A	p.A1042A	exonic	ENSG00000184507.16	.	synonymous SNV	ENSG00000184507.16:ENST00000614490.4:exon8:c.C3126A:p.A1042A	15q14	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NUTM1	375	1	405	37	0.083710407239819	TRUE	TRUE
ENSG00000137802.14	.	BCM	GRCh38.p13	chr15	41815725	41815725	+	C	C	T	Silent	SNP	ENST00000456763.6	exon13	c.C1437T	p.R479R	exonic	ENSG00000137802.14	.	synonymous SNV	ENSG00000137802.14:ENST00000456763.6:exon13:c.C1437T:p.R479R	15q15.1	C3L-03123	3.302e-05	9.638e-05	0.0002	0	0	1.501e-05	0	0	rs150429615	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAPKBP1	249	0	300	24	0.0740740740740741	TRUE	NA
ENSG00000168970.22	.	BCM	GRCh38.p13	chr15	41844572	41844572	+	C	C	T	Silent	SNP	ENST00000452633.5	exon13	c.C981T	p.C327C	exonic	ENSG00000168970.22;ENSG00000243708.10	.	synonymous SNV	ENSG00000243708.10:ENST00000452633.5:exon13:c.C981T:p.C327C,ENSG00000168970.22:ENST00000382448.8:exon17:c.C1674T:p.C558C	15q15.1	C3L-03123	1.648e-05	9.612e-05	8.642e-05	0	0	0	0	0	rs754262196	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58022293;OCCURENCE=1(large_intestine)	JMJD7-PLA2G4B	427	1	495	46	0.0850277264325323	TRUE	TRUE
ENSG00000137877.10	.	BCM	GRCh38.p13	chr15	41867610	41867610	+	C	C	T	Silent	SNP	ENST00000320955.8	exon35	c.G6240A	p.S2080S	exonic	ENSG00000137877.10	.	synonymous SNV	ENSG00000137877.10:ENST00000320955.8:exon35:c.G6240A:p.S2080S	15q15.1	C3L-03123	1.657e-05	0	0	0	0	0	0	0.0001	rs768341497	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58025373;OCCURENCE=1(stomach)	SPTBN5	467	0	588	73	0.110438729198185	TRUE	TRUE
ENSG00000166035.11	.	BCM	GRCh38.p13	chr15	58541892	58541892	+	C	C	T	Silent	SNP	ENST00000299022.10	exon3	c.C381T	p.H127H	exonic	ENSG00000166035.11	.	synonymous SNV	ENSG00000166035.11:ENST00000299022.10:exon3:c.C381T:p.H127H	15q21.3	C3L-03123	8.73e-06	0	0	0	0	1.574e-05	0	0	rs776118661	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LIPC	456	0	497	71	0.125	TRUE	NA
ENSG00000169118.18	.	BCM	GRCh38.p13	chr15	64207566	64207566	+	G	G	A	Silent	SNP	ENST00000303052.13	exon7	c.C708T	p.A236A	exonic	ENSG00000169118.18	.	synonymous SNV	ENSG00000169118.18:ENST00000303052.13:exon7:c.C708T:p.A236A	15q22.31	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CSNK1G1	357	0	414	29	0.0654627539503386	TRUE	TRUE
ENSG00000103811.17	.	BCM	GRCh38.p13	chr15	78931504	78931504	+	C	C	T	Silent	SNP	ENST00000220166.10	exon7	c.G495A	p.A165A	exonic	ENSG00000103811.17	.	synonymous SNV	ENSG00000103811.17:ENST00000220166.10:exon7:c.G495A:p.A165A	15q25.1	C3L-03123	0.0002	0.0017	8.658e-05	0.0001	0	0	0	0	rs140674602	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTSH	523	0	489	39	0.0738636363636364	TRUE	NA
ENSG00000103245.14	.	BCM	GRCh38.p13	chr16	736300	736300	+	A	A	G	Silent	SNP	ENST00000251588.7	exon4	c.T405C	p.T135T	exonic	ENSG00000103245.14	.	synonymous SNV	ENSG00000103245.14:ENST00000251588.7:exon4:c.T405C:p.T135T	16p13.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CIAO3	361	1	389	43	0.099537037037037	TRUE	TRUE
ENSG00000100726.15	.	BCM	GRCh38.p13	chr16	1509924	1509924	+	C	C	T	Silent	SNP	ENST00000262319.11	exon21	c.C2502T	p.P834P	exonic	ENSG00000100726.15	.	synonymous SNV	ENSG00000100726.15:ENST00000262319.11:exon21:c.C2502T:p.P834P	16p13.3	C3L-03123	5.066e-05	0	0	0	0	9.374e-05	0	0	rs776080837	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TELO2	260	0	294	52	0.15028901734104	TRUE	NA
ENSG00000171490.13	.	BCM	GRCh38.p13	chr16	11846783	11846783	+	G	G	A	Silent	SNP	ENST00000571133.6	exon4	c.C445T	p.L149L	exonic	ENSG00000171490.13	.	synonymous SNV	ENSG00000171490.13:ENST00000571133.6:exon4:c.C445T:p.L149L	16p13.13	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RSL1D1	312	0	368	28	0.0707070707070707	TRUE	TRUE
ENSG00000102871.16	.	BCM	GRCh38.p13	chr16	67155139	67155139	+	C	C	T	Silent	SNP	ENST00000345057.9	exon4	c.G585A	p.P195P	exonic	ENSG00000102871.16	.	synonymous SNV	ENSG00000102871.16:ENST00000345057.9:exon4:c.G585A:p.P195P	16q22.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50757919;OCCURENCE=1(large_intestine)	TRADD	318	0	426	52	0.108786610878661	NA	TRUE
ENSG00000103064.15	.	BCM	GRCh38.p13	chr16	68275062	68275062	+	C	C	T	Silent	SNP	ENST00000219343.11	exon3	c.C336T	p.Y112Y	exonic	ENSG00000103064.15	.	synonymous SNV	ENSG00000103064.15:ENST00000219343.11:exon3:c.C336T:p.Y112Y	16q22.1	C3L-03123	8.236e-05	0	0	0	0	8.99e-05	0	0.0002	rs144605306	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54718761;OCCURENCE=1(endometrium)	SLC7A6	460	0	483	95	0.164359861591695	TRUE	TRUE
ENSG00000140836.17	.	BCM	GRCh38.p13	chr16	72959258	72959258	+	C	C	T	Silent	SNP	ENST00000268489.10	exon2	c.G888A	p.S296S	exonic	ENSG00000140836.17	.	synonymous SNV	ENSG00000140836.17:ENST00000268489.10:exon2:c.G888A:p.S296S	16q22.3	C3L-03123	4.118e-05	0	0	0	0	2.997e-05	0	0.0002	rs377655061	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFHX3	308	0	376	21	0.052896725440806	TRUE	NA
ENSG00000169992.10	.	BCM	GRCh38.p13	chr17	7417226	7417226	+	G	G	A	Silent	SNP	ENST00000302926.7	exon7	c.G1935A	p.P645P	exonic	ENSG00000169992.10	.	synonymous SNV	ENSG00000169992.10:ENST00000302926.7:exon7:c.G1935A:p.P645P	17p13.1	C3L-03123	3.219e-05	0.0005	0	0	0	0	0	0	rs367900044	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NLGN2	212	0	161	36	0.182741116751269	TRUE	NA
ENSG00000176994.11	.	BCM	GRCh38.p13	chr17	18316944	18316944	+	A	A	G	Silent	SNP	ENST00000406438.5	exon1	c.A1155G	p.K385K	exonic	ENSG00000176994.11	.	synonymous SNV	ENSG00000176994.11:ENST00000406438.5:exon1:c.A1155G:p.K385K	17p11.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMCR8	232	0	255	47	0.155629139072848	TRUE	NA
ENSG00000160602.14	.	BCM	GRCh38.p13	chr17	28734872	28734872	+	T	T	C	Silent	SNP	ENST00000268766.11	exon3	c.T354C	p.H118H	exonic	ENSG00000160602.14	.	synonymous SNV	ENSG00000160602.14:ENST00000268766.11:exon3:c.T354C:p.H118H	17q11.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NEK8	570	2	712	88	0.11	TRUE	TRUE
ENSG00000196535.16	.	BCM	GRCh38.p13	chr17	29115084	29115084	+	G	G	A	Silent	SNP	ENST00000527372.6	exon14	c.C2334T	p.S778S	exonic	ENSG00000196535.16	.	synonymous SNV	ENSG00000196535.16:ENST00000527372.6:exon14:c.C2334T:p.S778S	17q11.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO18A	169	1	176	30	0.145631067961165	TRUE	TRUE
ENSG00000125686.12	.	BCM	GRCh38.p13	chr17	39410457	39410457	+	C	C	T	Silent	SNP	ENST00000300651.11	exon17	c.G1764A	p.S588S	exonic	ENSG00000125686.12	.	synonymous SNV	ENSG00000125686.12:ENST00000300651.11:exon17:c.G1764A:p.S588S	17q12	C3L-03123	8.236e-06	0	0	0	0	1.498e-05	0	0	rs755797231	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MED1	456	0	563	79	0.123052959501558	TRUE	NA
ENSG00000126368.6	.	BCM	GRCh38.p13	chr17	40095984	40095984	+	C	C	T	Silent	SNP	ENST00000246672.4	exon5	c.G708A	p.P236P	exonic	ENSG00000126368.6	.	synonymous SNV	ENSG00000126368.6:ENST00000246672.4:exon5:c.G708A:p.P236P	17q21.1	C3L-03123	0.0002	0.0004	0.0002	0	0	0.0002	0.0012	0	rs147503529	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99225674;OCCURENCE=1(endometrium)	NR1D1	296	0	519	49	0.0862676056338028	TRUE	NA
ENSG00000049283.18	.	BCM	GRCh38.p13	chr17	50541329	50541329	+	T	T	C	Silent	SNP	ENST00000268933.8	exon8	c.T1350C	p.P450P	exonic	ENSG00000049283.18	.	synonymous SNV	ENSG00000049283.18:ENST00000268933.8:exon8:c.T1350C:p.P450P	17q21.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EPN3	169	0	232	34	0.12781954887218	TRUE	TRUE
ENSG00000167306.20	.	BCM	GRCh38.p13	chr18	49839163	49839163	+	G	G	A	Silent	SNP	ENST00000285039.12	exon36	c.C4833T	p.G1611G	exonic	ENSG00000167306.20	.	synonymous SNV	ENSG00000167306.20:ENST00000285039.12:exon36:c.C4833T:p.G1611G	18q21.1	C3L-03123	9.109e-05	0.0008	0.0003	0	0	0	0	0	rs376462138	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO5B	454	0	457	47	0.0932539682539683	TRUE	NA
ENSG00000105143.12	.	BCM	GRCh38.p13	chr19	14956691	14956691	+	G	G	A	Silent	SNP	ENST00000221742.7	exon6	c.C954T	p.I318I	exonic	ENSG00000105143.12	.	synonymous SNV	ENSG00000105143.12:ENST00000221742.7:exon6:c.C954T:p.I318I	19p13.12	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC1A6	155	0	133	18	0.119205298013245	TRUE	TRUE
ENSG00000130477.15	.	BCM	GRCh38.p13	chr19	17630735	17630735	+	G	G	A	Silent	SNP	ENST00000519716.6	exon29	c.C3444T	p.F1148F	exonic	ENSG00000130477.15	.	synonymous SNV	ENSG00000130477.15:ENST00000519716.6:exon29:c.C3444T:p.F1148F	19p13.11	C3L-03123	8.295e-06	0	0	0	0	0	0	6.059e-05	rs570146186	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UNC13A	257	0	288	44	0.132530120481928	TRUE	NA
ENSG00000130283.9	.	BCM	GRCh38.p13	chr19	18869257	18869257	+	C	C	T	Silent	SNP	ENST00000247005.8	exon8	c.G459A	p.A153A	exonic	ENSG00000130283.9;ENSG00000223802.7	.	synonymous SNV	ENSG00000130283.9:ENST00000247005.8:exon8:c.G459A:p.A153A,ENSG00000223802.7:ENST00000623927.1:exon8:c.G459A:p.A153A	19p13.11	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GDF1	250	0	223	41	0.15530303030303	TRUE	TRUE
ENSG00000198597.9	.	BCM	GRCh38.p13	chr19	30445392	30445392	+	C	C	T	Silent	SNP	ENST00000355537.4	exon2	c.C1830T	p.H610H	exonic	ENSG00000198597.9	.	synonymous SNV	ENSG00000198597.9:ENST00000355537.4:exon2:c.C1830T:p.H610H	19q12	C3L-03123	5.767e-05	0	0.0005	0	0	0	0	6.057e-05	rs771230573	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62830782;OCCURENCE=1(large_intestine),1(endometrium)	ZNF536	403	0	437	55	0.111788617886179	TRUE	TRUE
ENSG00000196218.13	.	BCM	GRCh38.p13	chr19	38451796	38451796	+	C	C	T	Silent	SNP	ENST00000359596.8	exon12	c.C1155T	p.D385D	exonic	ENSG00000196218.13	.	synonymous SNV	ENSG00000196218.13:ENST00000359596.8:exon12:c.C1155T:p.D385D	19q13.2	C3L-03123	8.262e-05	0.0002	8.645e-05	0.0006	0	3.009e-05	0	0	rs144658230	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62091304;OCCURENCE=1(oesophagus),1(central_nervous_system),1(haematopoietic_and_lymphoid_tissue)	RYR1	708	0	814	122	0.13034188034188	TRUE	TRUE
ENSG00000263002.8	.	BCM	GRCh38.p13	chr19	44156637	44156637	+	C	C	T	Silent	SNP	ENST00000426739.7	exon6	c.C621T	p.D207D	exonic	ENSG00000263002.8	.	synonymous SNV	ENSG00000263002.8:ENST00000426739.7:exon6:c.C621T:p.D207D	19q13.31	C3L-03123	8.241e-05	0.0006	0	0.0001	0	0	0	0.0002	rs375861956	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV70604151;OCCURENCE=1(liver)	ZNF234	366	2	381	76	0.166301969365427	NA	TRUE
ENSG00000142230.13	.	BCM	GRCh38.p13	chr19	47152912	47152912	+	C	C	T	Silent	SNP	ENST00000270225.12	exon4	c.C399T	p.C133C	exonic	ENSG00000142230.13	.	synonymous SNV	ENSG00000142230.13:ENST00000270225.12:exon4:c.C399T:p.C133C	19q13.32	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SAE1	117	0	160	26	0.139784946236559	NA	TRUE
ENSG00000063169.10	.	BCM	GRCh38.p13	chr19	47694947	47694947	+	C	C	T	Silent	SNP	ENST00000396720.7	exon9	c.C2943T	p.A981A	exonic	ENSG00000063169.10	.	synonymous SNV	ENSG00000063169.10:ENST00000396720.7:exon9:c.C2943T:p.A981A	19q13.33	C3L-03123	0.0017	0.0204	0.0002	0.0005	0	1.924e-05	0	0.0001	rs10415283	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV104708512;OCCURENCE=1(skin)	BICRA	27	0	47	9	0.160714285714286	TRUE	NA
ENSG00000104951.16	.	BCM	GRCh38.p13	chr19	49889883	49889883	+	C	C	T	Silent	SNP	ENST00000391826.7	exon8	c.G1491A	p.A497A	exonic	ENSG00000104951.16	.	synonymous SNV	ENSG00000104951.16:ENST00000391826.7:exon8:c.G1491A:p.A497A	19q13.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55577025;OCCURENCE=2(large_intestine)	IL4I1	148	0	195	23	0.105504587155963	TRUE	TRUE
ENSG00000160505.16	.	BCM	GRCh38.p13	chr19	55857912	55857912	+	G	G	A	Silent	SNP	ENST00000301295.11	exon3	c.G519A	p.S173S	exonic	ENSG00000160505.16	.	synonymous SNV	ENSG00000160505.16:ENST00000301295.11:exon3:c.G519A:p.S173S	19q13.43	C3L-03123	8.238e-06	0	0	0	0	0	0	6.056e-05	rs749484722	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56709907;OCCURENCE=3(oesophagus),1(large_intestine)	NLRP4	363	0	402	44	0.0986547085201794	TRUE	TRUE
ENSG00000125878.6	.	BCM	GRCh38.p13	chr20	610222	610222	+	G	G	A	Silent	SNP	ENST00000246080.3	exon1	c.C16T	p.L6L	exonic	ENSG00000125878.6	.	synonymous SNV	ENSG00000125878.6:ENST00000246080.3:exon1:c.C16T:p.L6L	20p13	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TCF15	56	0	86	8	0.0851063829787234	TRUE	NA
ENSG00000088888.18	.	BCM	GRCh38.p13	chr20	3865985	3865985	+	G	G	A	Silent	SNP	ENST00000428216.4	exon7	c.G1461A	p.A487A	exonic	ENSG00000088888.18	.	synonymous SNV	ENSG00000088888.18:ENST00000428216.4:exon7:c.G1461A:p.A487A	20p13	C3L-03123	2.548e-05	0.0003	0	0	0	0	0	0	rs767756615	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63927348;OCCURENCE=1(skin)	MAVS	316	0	371	46	0.11031175059952	TRUE	TRUE
ENSG00000101294.18	.	BCM	GRCh38.p13	chr20	31514599	31514599	+	C	C	T	Silent	SNP	ENST00000340852.9	exon1	c.C48T	p.G16G	exonic	ENSG00000101294.18	.	synonymous SNV	ENSG00000101294.18:ENST00000340852.9:exon1:c.C48T:p.G16G	20q11.21	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HM13	643	0	862	110	0.113168724279835	TRUE	TRUE
ENSG00000159140.21	.	BCM	GRCh38.p13	chr21	33554064	33554064	+	T	T	C	Silent	SNP	ENST00000356577.10	exon3	c.T4833C	p.G1611G	exonic	ENSG00000159140.21	.	synonymous SNV	ENSG00000159140.21:ENST00000356577.10:exon3:c.T4833C:p.G1611G	21q22.11	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SON	301	0	320	23	0.0670553935860058	TRUE	TRUE
ENSG00000177398.18	.	BCM	GRCh38.p13	chr21	42127831	42127831	+	C	C	T	Silent	SNP	ENST00000408910.6	exon20	c.C3690T	p.I1230I	exonic	ENSG00000177398.18	.	synonymous SNV	ENSG00000177398.18:ENST00000408910.6:exon20:c.C3690T:p.I1230I	21q22.3	C3L-03123	2.494e-05	0.0001	0	0.0002	0	0	0	0	rs1021984474	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UMODL1	171	0	216	18	0.0769230769230769	TRUE	NA
ENSG00000099994.11	.	BCM	GRCh38.p13	chr22	24187254	24187254	+	A	A	G	Silent	SNP	ENST00000358321.4	exon11	c.A1695G	p.S565S	exonic	ENSG00000099994.11	.	synonymous SNV	ENSG00000099994.11:ENST00000358321.4:exon11:c.A1695G:p.S565S	22q11.23	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUSD2	438	0	499	80	0.138169257340242	TRUE	TRUE
ENSG00000133454.16	.	BCM	GRCh38.p13	chr22	25847534	25847534	+	A	A	G	Silent	SNP	ENST00000335473.12	exon20	c.A3657G	p.P1219P	exonic	ENSG00000133454.16	.	synonymous SNV	ENSG00000133454.16:ENST00000335473.12:exon20:c.A3657G:p.P1219P	22q12.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO18B	660	0	706	92	0.115288220551378	TRUE	TRUE
ENSG00000100154.14	.	BCM	GRCh38.p13	chr22	27982707	27982707	+	G	G	T	Silent	SNP	ENST00000397906.6	exon23	c.C6960A	p.P2320P	exonic	ENSG00000100154.14	.	synonymous SNV	ENSG00000100154.14:ENST00000397906.6:exon23:c.C6960A:p.P2320P	22q12.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67416297;OCCURENCE=1(large_intestine)	TTC28	255	0	333	35	0.0951086956521739	TRUE	TRUE
ENSG00000100078.4	.	BCM	GRCh38.p13	chr22	31136946	31136946	+	G	G	A	Silent	SNP	ENST00000215885.4	exon5	c.C1161T	p.S387S	exonic	ENSG00000100078.4	.	synonymous SNV	ENSG00000100078.4:ENST00000215885.4:exon5:c.C1161T:p.S387S	22q12.2	C3L-03123	4.32e-05	0	0.0004	0	0	2.587e-05	0	0	rs777451080	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLA2G3	154	1	174	27	0.134328358208955	TRUE	NA
ENSG00000130021.15	.	BCM	GRCh38.p13	chrX	7105834	7105834	+	A	A	G	Silent	SNP	ENST00000381077.10	exon2	c.T66C	p.T22T	exonic	ENSG00000130021.15	.	synonymous SNV	ENSG00000130021.15:ENST00000381077.10:exon2:c.T66C:p.T22T	Xp22.31	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PUDP	242	0	231	33	0.125	TRUE	TRUE
ENSG00000102054.18	.	BCM	GRCh38.p13	chrX	16852611	16852611	+	A	A	G	Silent	SNP	ENST00000380087.7	exon8	c.T903C	p.D301D	exonic	ENSG00000102054.18	.	synonymous SNV	ENSG00000102054.18:ENST00000380087.7:exon8:c.T903C:p.D301D	Xp22.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBBP7	242	0	240	34	0.124087591240876	TRUE	TRUE
ENSG00000071859.15	.	BCM	GRCh38.p13	chrX	154448524	154448524	+	C	C	T	Silent	SNP	ENST00000393600.8	exon5	c.C483T	p.D161D	exonic	ENSG00000071859.15	.	synonymous SNV	ENSG00000071859.15:ENST00000393600.8:exon5:c.C483T:p.D161D	Xq28	C3L-03123	1.142e-05	0	0	0.0002	0	0	0	0	rs782616761	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM50A	304	0	321	35	0.098314606741573	TRUE	NA
ENSG00000054523.17	.	BCM	GRCh38.p13	chr1	10303310	10303310	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000054523.17	.	.	.	1p36.22	C3L-03123	8.256e-06	9.684e-05	0	0	0	0	0	0	rs780600214	11.16	D	D	D	D	.	D	.	T	D	0.697	D	D	D	0.406	0.169	0.576	.	.	.	T	T	T	D	1.947	18.850	0.999	D	N	0.554	5.487	0.547	5.620	1.000	0.707	0.546	0.725	0.714	.	6.130	5.210	2.450	1.023	0.593	1.000	0.996	0.992	236	.	.	.	.	KIF1B	708	0	701	69	0.0896103896103896	TRUE	NA
ENSG00000252151.1	.	BCM	GRCh38.p13	chr1	14180493	14180493	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000252151.1;ENSG00000231606.2	dist=56158;dist=41394	.	.	1p36.21	C3L-03123	.	.	.	.	.	.	.	.	rs374201920	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNU6-1265P	310	0	299	33	0.0993975903614458	TRUE	NA
ENSG00000143387.13	.	BCM	GRCh38.p13	chr1	150807301	150807301	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000143387.13	.	.	.	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	rs908212829	1.13	D	.	.	.	.	N	.	T	N	.	T	T	.	0.119	0.429	0.465	.	.	T	T	T	T	T	0.238	3.560	0.544	N	N	-0.857	0.575	-0.990	0.502	1.000	0.554	0.588	0.492	0.649	.	3.920	2.790	0.199	-0.040	-0.584	0.000	0.000	0.002	65	.	.	.	.	CTSK	259	0	273	24	0.0808080808080808	TRUE	NA
ENSG00000143554.14	.	BCM	GRCh38.p13	chr1	153775490	153775490	+	C	C	T	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000143554.14	ENST00000624995.4:c.-8C>T	.	.	1q21.3	C3L-03123	.	.	.	.	.	.	.	.	.	3.16	D	D	.	.	N	N	.	T	N	0.129	T	T	D	0.053	0.245	0.143	0.123	T	T	T	T	T	.	0.520	6.715	0.990	N	N	-1.198	0.229	-1.274	0.227	1.000	0.442	0.522	0.504	0.373	.	4.360	-5.630	-0.273	-0.235	0.524	0.001	0.088	0.065	81	.	.	.	.	SLC27A3	579	1	723	54	0.0694980694980695	TRUE	NA
ENSG00000160818.16	.	BCM	GRCh38.p13	chr1	156597844	156597844	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000160818.16	.	.	.	1q22	C3L-03123	0.0172	0.0151	0.0155	0.0319	0.0055	0.0154	0.0139	0.0207	rs62617853	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPATCH4	184	0	197	24	0.108597285067873	TRUE	NA
ENSG00000163395.17	.	BCM	GRCh38.p13	chr1	201207224	201207224	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000163395.17	.	.	.	1q32.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGFN1	331	0	357	44	0.109725685785536	TRUE	TRUE
ENSG00000150540.14	.	BCM	GRCh38.p13	chr2	137981321	137981321	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000150540.14	.	.	.	2q22.1	C3L-03123	8.237e-06	0	0	0.0001	0	0	0	0	rs760879749	2.15	D	D	B	B	.	N	.	.	N	0.127	T	T	T	0.036	0.154	0.222	.	.	.	T	T	T	T	-0.198	0.516	0.661	N	N	-1.364	0.132	-1.463	0.122	0.999	0.554	0.574	0.618	0.492	.	4.130	-2.800	-0.432	-0.938	-0.166	0.000	0.053	0.030	809	.	.	.	ID=COSV54507117;OCCURENCE=1(cervix),1(large_intestine)	HNMT	374	1	400	116	0.224806201550388	TRUE	TRUE
ENSG00000159692.15	.	BCM	GRCh38.p13	chr4	1238123	1238123	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000159692.15	.	.	.	4p16.3	C3L-03123	0.0002	0.0001	0	0.0018	0	1.605e-05	0	0.0004	rs370349402	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTBP1	213	0	244	40	0.140845070422535	TRUE	NA
ENSG00000159788.19	.	BCM	GRCh38.p13	chr4	3417657	3417657	+	T	T	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000159788.19	.	.	.	4p16.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RGS12	80	0	91	5	0.0520833333333333	TRUE	NA
ENSG00000159788.19	.	BCM	GRCh38.p13	chr4	3428210	3428210	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000159788.19	.	.	.	4p16.3	C3L-03123	3.361e-05	0	0	0.0001	0.0002	1.539e-05	0	6.101e-05	rs766043248	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58748813;OCCURENCE=2(large_intestine)	RGS12	149	0	174	24	0.121212121212121	TRUE	NA
ENSG00000145362.20	.	BCM	GRCh38.p13	chr4	113372562	113372562	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000145362.20	.	.	.	4q26	C3L-03123	.	.	.	.	.	.	.	.	.	3.14	T	T	.	.	.	D	.	D	N	0.099	T	T	T	0.162	0.169	0.531	.	.	.	T	T	T	T	2.099	20.100	0.995	D	N	0.172	3.182	0.231	3.337	0.942	0.563	0.574	0.609	0.542	.	5.660	3.760	1.652	1.176	0.676	1.000	1.000	0.995	608	.	.	.	.	ANK2	276	0	308	42	0.12	TRUE	TRUE
ENSG00000232633.4	.	BCM	GRCh38.p13	chr5	113340651	113340651	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000232633.4	.	.	.	5q22.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC079465.1	454	0	570	73	0.11353032659409	TRUE	TRUE
ENSG00000198624.13	.	BCM	GRCh38.p13	chr5	151183232	151183232	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000198624.13	ENST00000355417.7:c.*205G>A	.	.	5q33.1	C3L-03123	0.0014	0.0276	0.0053	0	0	0.0005	0	0	rs79663067	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC69	674	0	668	77	0.103355704697987	TRUE	NA
ENSG00000145975.15	.	BCM	GRCh38.p13	chr6	4078899	4078899	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000145975.15	ENST00000274673.8:c.-1485C>T	.	.	6p25.2	C3L-03123	.	.	.	.	.	.	.	.	rs902801457	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99212675;OCCURENCE=1(stomach)	FAM217A	112	0	133	16	0.10738255033557	TRUE	NA
ENSG00000128573.26	.	BCM	GRCh38.p13	chr7	114690786	114690786	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000128573.26	ENST00000350908.9:c.*860C>T	.	.	7q31.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63483636;OCCURENCE=1(pancreas)	FOXP2	350	0	375	54	0.125874125874126	TRUE	NA
ENSG00000105967.16	.	BCM	GRCh38.p13	chr7	116110792	116110792	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000105967.16;ENSG00000279086.1	dist=80029;dist=98442	.	.	7q31.2	C3L-03123	.	.	.	.	.	.	.	.	.	1.16	T	T	B	B	.	N	.	T	N	0.235	T	T	T	0.022	0.280	0.171	.	.	.	T	T	T	T	1.495	15.700	0.974	D	N	-0.249	1.744	-0.127	1.973	0.999	0.624	0.660	0.574	0.621	.	5.050	4.170	2.219	1.026	0.594	0.807	0.997	0.908	658	.	.	.	.	TFEC	170	0	193	24	0.110599078341014	TRUE	TRUE
ENSG00000197558.13	.	BCM	GRCh38.p13	chr7	149800317	149800317	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000197558.13	.	.	.	7q36.1	C3L-03123	.	.	.	.	.	.	.	.	.	0.6	.	T	.	.	.	.	.	.	.	0.285	.	.	.	.	.	0.170	.	T	.	T	T	.	T	0.463	6.113	0.765	N	.	.	.	.	.	0.603	0.057	0.078	0.074	0.058	0.221	4.520	-3.500	0.152	0.118	-0.269	0.000	0.103	0.210	982	.	.	.	.	SSPO	258	0	301	27	0.0823170731707317	TRUE	TRUE
ENSG00000204876.4	.	BCM	GRCh38.p13	chr7	155964751	155964751	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000204876.4	.	.	.	7q36.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC021218.1	82	0	87	12	0.121212121212121	TRUE	NA
ENSG00000167632.17	.	BCM	GRCh38.p13	chr8	140458550	140458550	+	C	C	T	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000167632.17	dist=806	.	.	8q24.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRAPPC9	390	0	492	68	0.121428571428571	TRUE	TRUE
ENSG00000147789.15	.	BCM	GRCh38.p13	chr8	144838062	144838062	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000147789.15	.	.	.	8q24.3	C3L-03123	.	.	.	.	.	.	.	.	.	1.17	D	T	P	P	.	N	.	T	N	0.112	T	T	T	0.029	0.210	0.439	.	.	T	T	T	T	T	-0.131	0.716	0.930	N	N	-0.597	0.994	-0.845	0.695	0.990	0.461	0.577	0.576	0.636	.	2.060	0.063	-1.250	0.704	0.599	0.000	0.005	0.006	754	.	.	.	.	ZNF7	250	0	302	35	0.103857566765579	TRUE	TRUE
ENSG00000147955.17	.	BCM	GRCh38.p13	chr9	34635629	34635629	+	T	T	C	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000147955.17	ENST00000277010.9:c.*3A>G	.	.	9p13.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SIGMAR1	689	0	968	73	0.0701248799231508	TRUE	NA
ENSG00000187753.13	.	BCM	GRCh38.p13	chr9	86229605	86229605	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000187753.13	ENST00000376001.7:c.-2C>T	.	.	9q21.33	C3L-03123	8.543e-06	0	0	0	0	1.548e-05	0	0	rs779590719	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59251420;OCCURENCE=1(large_intestine),2(endometrium)	C9orf153	299	0	289	40	0.121580547112462	TRUE	NA
ENSG00000232850.3	.	BCM	GRCh38.p13	chr9	128129127	128129127	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000232850.3	.	.	.	9q34.11	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL590708.1	450	0	554	63	0.102106969205835	TRUE	NA
ENSG00000160293.17	.	BCM	GRCh38.p13	chr9	133764061	133764061	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000160293.17	ENST00000371850.8:c.*1C>T	.	.	9q34.2	C3L-03123	0.0017	0.0007	0.0011	0.0001	0.0002	0.0024	0.0011	0.0012	rs145903019	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VAV2	344	0	385	36	0.0855106888361045	TRUE	NA
ENSG00000160349.9	.	BCM	GRCh38.p13	chr9	135526452	135526452	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000160349.9	ENST00000263598.6:c.*105C>T	.	.	9q34.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LCN1	117	0	183	10	0.0518134715025907	TRUE	NA
ENSG00000152463.15	.	BCM	GRCh38.p13	chr10	15056836	15056836	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000152463.15	.	.	.	10p13	C3L-03123	.	.	.	.	.	.	.	.	.	1.17	T	T	B	B	.	N	.	T	D	0.173	T	T	T	0.008	0.294	0.088	0.008	.	T	T	T	T	T	-0.048	1.062	0.523	N	N	-1.107	0.300	-1.248	0.245	0.000	0.554	0.588	0.574	0.530	.	.	.	0.376	-0.228	-0.276	0.003	0.001	0.001	895	.	.	.	.	OLAH	148	0	199	22	0.0995475113122172	TRUE	TRUE
ENSG00000198788.8	.	BCM	GRCh38.p13	chr11	1110350	1110350	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000198788.8;ENSG00000215182.8	dist=6894;dist=47603	.	.	11p15.5	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC2	194	0	259	17	0.0615942028985507	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65502315	65502315	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	140	0	176	35	0.165876777251185	TRUE	NA
ENSG00000174871.11	.	BCM	GRCh38.p13	chr11	66281440	66281440	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000174871.11	.	.	.	11q13.2	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNIH2	352	0	385	47	0.108796296296296	TRUE	NA
ENSG00000177098.8	.	BCM	GRCh38.p13	chr11	118133949	118133949	+	A	A	C	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000177098.8	ENST00000324727.8:c.*3078T>G	.	.	11q23.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCN4B	183	0	184	27	0.127962085308057	TRUE	NA
ENSG00000151136.15	.	BCM	GRCh38.p13	chr12	107580977	107580977	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000151136.15	.	.	.	12q23.3	C3L-03123	.	.	.	.	.	.	.	.	.	2.14	D	T	.	.	.	D	.	T	N	0.082	T	T	T	0.038	0.385	0.451	.	.	.	T	T	T	T	1.503	15.760	0.986	N	N	-0.775	0.692	-0.714	0.879	0.964	0.497	0.590	0.616	0.542	.	4.180	-0.006	0.156	1.293	0.686	0.033	0.915	0.895	777	.	.	.	.	BTBD11	371	0	344	65	0.158924205378973	TRUE	NA
ENSG00000151835.16	.	BCM	GRCh38.p13	chr13	23329463	23329463	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000151835.16	ENST00000382292.9:c.*673G>A	.	.	13q12.12	C3L-03123	.	.	.	.	.	.	.	.	.	0.9	.	.	.	.	.	N	.	.	.	.	T	T	.	0.173	.	0.410	.	.	.	T	T	T	T	0.645	7.942	0.870	N	N	-0.942	0.470	-1.024	0.460	1.000	0.706	0.710	0.659	0.613	.	5.840	-3.760	0.086	-0.216	0.599	0.006	0.128	0.679	988	.	.	.	.	SACS	184	0	205	18	0.0807174887892377	TRUE	NA
ENSG00000182957.16	.	BCM	GRCh38.p13	chr13	24249619	24249619	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000182957.16	ENST00000382095.8:c.-80G>A	.	.	13q12.12	C3L-03123	0.0001	0.0017	0	0	0	0	0	0	rs371511214	8.15	D	T	.	.	.	D	.	T	N	0.626	D	D	D	0.288	.	0.721	1.120	T	.	T	T	T	D	4.109	27.800	0.999	D	D	0.106	2.911	0.096	2.717	1.000	0.617	0.588	0.786	0.655	.	5.800	4.960	7.258	1.172	0.672	1.000	0.020	0.523	866	.	.	.	.	SPATA13	447	1	544	73	0.118314424635332	TRUE	NA
ENSG00000196364.9	.	BCM	GRCh38.p13	chr16	1262917	1262917	+	A	A	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000196364.9	.	.	.	16p13.3	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRSS29P	453	0	485	52	0.0968342644320298	TRUE	NA
ENSG00000226180.3	.	BCM	GRCh38.p13	chr16	87695638	87695638	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000226180.3	.	.	.	16q24.2	C3L-03123	.	.	.	.	.	.	.	.	rs767820964	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC010536.1	310	0	375	43	0.102870813397129	TRUE	NA
ENSG00000005156.12	.	BCM	GRCh38.p13	chr17	35002998	35002998	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000005156.12	.	.	.	17q12	C3L-03123	.	.	.	.	.	.	.	.	rs753303003	5.14	D	D	.	.	.	D	.	T	N	0.265	T	T	D	0.060	0.242	0.366	.	.	.	T	T	T	T	1.649	16.690	0.998	D	N	-0.397	1.389	-0.271	1.625	0.612	0.461	0.577	0.576	0.492	.	5.400	2.160	0.757	-0.237	-0.171	0.994	0.828	0.925	855	.	.	.	.	LIG3	284	0	392	40	0.0925925925925926	TRUE	NA
ENSG00000188662.6	.	BCM	GRCh38.p13	chr17	50171817	50171817	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000188662.6	.	.	.	17q21.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	H1-9P	472	1	571	101	0.150297619047619	TRUE	NA
ENSG00000131943.18	.	BCM	GRCh38.p13	chr19	29702425	29702425	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000131943.18	ENST00000392278.2:c.*287C>T	.	.	19q12	C3L-03123	.	.	.	.	.	.	.	.	rs996766909	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C19orf12	977	1	1055	140	0.117154811715481	TRUE	NA
ENSG00000186008.7	.	BCM	GRCh38.p13	chr19	34092908	34092908	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000186008.7	.	.	.	19q13.11	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RPS4XP21	300	0	334	48	0.12565445026178	TRUE	NA
ENSG00000268049.1	.	BCM	GRCh38.p13	chr19	58359172	58359172	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000268049.1	.	.	.	19q13.43	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC012313.2	414	1	456	70	0.133079847908745	TRUE	NA
ENSG00000149451.18	.	BCM	GRCh38.p13	chr20	3669713	3669713	+	T	T	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000149451.18	.	.	.	20p13	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAM33	263	0	345	28	0.0750670241286863	TRUE	NA
ENSG00000128165.9	.	BCM	GRCh38.p13	chr22	50482950	50482950	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000128165.9	ENST00000395737.2:c.*47C>T	.	.	22q13.33	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADM2	262	0	380	48	0.11214953271028	TRUE	NA
ENSG00000198223.16	.	BCM	GRCh38.p13	chrX	1309753	1309753	+	C	C	T	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000198223.16	ENST00000381524.8:c.*274C>T	.	.	Xp22.33	C3L-03123	0.0069	0.0548	0.0091	0	0	0	0	0.0005	rs144177234	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CSF2RA	44	0	45	9	0.166666666666667	TRUE	NA
ENSG00000223611.5	.	BCM	GRCh38.p13	chrX	24314182	24314182	+	C	C	T	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000223611.5	dist=867	.	.	Xp22.11	C3L-03123	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUPT20HL2	66	0	79	11	0.122222222222222	TRUE	NA
ENSG00000102225.16	.	BCM	GRCh38.p13	chrX	47223273	47223273	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000102225.16	.	.	.	Xp11.3	C3L-03123	0.0103	0.0039	0.0769	0.2442	0	0.0023	0.0331	0.0032	rs17550472	2.13	D	T	.	.	.	P	.	T	N	0.122	T	T	.	0.255	.	.	1.266	T	.	T	T	T	T	1.874	18.290	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.170	4.170	3.526	0.969	0.587	0.999	0.276	0.009	541	.	.	.	ID=COSV52094571;OCCURENCE=1(stomach),1(lung)	CDK16	313	0	327	45	0.120967741935484	TRUE	TRUE
ENSG00000123569.8	.	BCM	GRCh38.p13	chrX	104013796	104013796	+	G	G	A	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000123569.8	dist=109	.	.	Xq22.2	C3L-03123	0.0006	0	0	0	0	0	0	0.0013	rs782170537	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	H2BW1	262	0	327	40	0.108991825613079	TRUE	NA
ENSG00000060718.22	.	BCM	GRCh38.p13	chr1	103074775	103074775	+	T	T	A	Missense_Mutation	SNP	ENST00000370096.9	exon4	c.A494T	p.H165L	exonic	ENSG00000060718.22	.	nonsynonymous SNV	ENSG00000060718.22:ENST00000370096.9:exon4:c.A494T:p.H165L	1p21.1	C3N-02010	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.957	D	D	D	0.937	0.748	0.985	0.628	D	D	D	D	D	D	4.099	27.700	0.964	D	D	0.976	13.180	0.905	13.986	1.000	0.638	0.574	0.653	0.564	.	5.730	5.730	8.014	1.138	0.665	1.000	1.000	0.997	826	Laminin_G_domain	.	.	.	COL11A1	291	0	192	31	0.139013452914798	TRUE	TRUE
ENSG00000162729.14	.	BCM	GRCh38.p13	chr1	160093863	160093863	+	C	C	T	Missense_Mutation	SNP	ENST00000314485.12	exon3	c.G751A	p.D251N	exonic	ENSG00000162729.14	.	nonsynonymous SNV	ENSG00000162729.14:ENST00000314485.12:exon3:c.G751A:p.D251N	1q23.2	C3N-02010	1.657e-05	9.673e-05	0	0	0	1.508e-05	0	0	rs373796213	1.20	T	T	P	B	N	D	L	T	N	0.136	T	T	T	0.049	.	0.165	0.204	T	T	T	T	T	T	1.405	15.120	0.988	N	N	-0.562	1.058	-0.592	1.059	1.000	0.719	0.723	0.644	0.655	.	3.740	2.780	1.948	1.026	0.549	0.006	0.355	0.311	754	Immunoglobulin_subtype	.	.	.	IGSF8	311	0	282	36	0.113207547169811	TRUE	NA
ENSG00000198626.17	.	BCM	GRCh38.p13	chr1	237627960	237627960	+	C	C	T	Missense_Mutation	SNP	ENST00000366574.7	exon41	c.C6320T	p.T2107M	exonic	ENSG00000198626.17	.	nonsynonymous SNV	ENSG00000198626.17:ENST00000366574.7:exon41:c.C6320T:p.T2107M	1q43	C3N-02010	4.983e-05	0	8.678e-05	0.0001	0	3.005e-05	0	0.0001	rs370331492	17.19	D	.	D	D	D	D	M	D	D	0.736	D	D	D	0.805	.	0.903	0.775	T	D	T	D	D	D	3.285	24.100	0.999	D	D	0.769	8.205	0.682	7.422	0.998	0.554	0.574	0.618	0.564	.	5.170	5.170	7.881	1.026	0.549	1.000	0.876	0.224	911	.	.	.	ID=COSV63683450;OCCURENCE=1(endometrium)	RYR2	306	0	215	51	0.191729323308271	TRUE	TRUE
ENSG00000179921.15	.	BCM	GRCh38.p13	chr2	218262902	218262911	+	GCTGGGCTGC	GCTGGGCTGC	-	Frame_Shift_Del	DEL	ENST00000519574.2	exon2	c.178_187del	p.A60Sfs*53	exonic	ENSG00000179921.15	.	frameshift deletion	ENSG00000179921.15:ENST00000519574.2:exon2:c.178_187del:p.A60Sfs*53	2q35	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPBAR1	367	0	219	84	0.277227722772277	TRUE	TRUE
ENSG00000073803.14	.	BCM	GRCh38.p13	chr3	185473084	185473084	+	C	C	T	Nonsense_Mutation	SNP	ENST00000265026.8	exon11	c.C1753T	p.R585X	exonic	ENSG00000073803.14	.	stopgain	ENSG00000073803.14:ENST00000265026.8:exon11:c.C1753T:p.R585X	3q27.2	C3N-02010	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.381	.	.	.	.	.	.	.	.	.	D	D	.	.	6.941	36	0.998	D	N	0.701	7.132	0.558	5.739	1.000	0.563	0.654	0.602	0.568	.	5.470	4.600	3.816	0.096	0.599	1.000	0.753	0.978	739	.	.	.	ID=COSV53983886;OCCURENCE=2(large_intestine),1(haematopoietic_and_lymphoid_tissue),1(endometrium)	MAP3K13	406	1	368	46	0.111111111111111	TRUE	TRUE
ENSG00000083857.14	.	BCM	GRCh38.p13	chr4	186709194	186709194	+	A	A	C	Missense_Mutation	SNP	ENST00000441802.7	exon2	c.T634G	p.Y212D	exonic	ENSG00000083857.14	.	nonsynonymous SNV	ENSG00000083857.14:ENST00000441802.7:exon2:c.T634G:p.Y212D	4q35.2	C3N-02010	.	.	.	.	.	.	.	.	.	9.20	D	D	P	P	N	D	M	T	D	0.611	T	T	D	0.233	0.684	0.413	0.497	T	T	T	T	D	D	2.692	22.800	0.929	D	N	-0.003	2.501	-0.152	1.905	0.997	0.672	0.574	0.702	0.668	.	5.200	1.330	3.511	0.315	0.691	1.000	0.011	0.127	945	Cadherin-like	.	.	.	FAT1	201	0	105	43	0.290540540540541	TRUE	TRUE
ENSG00000066230.12	.	BCM	GRCh38.p13	chr5	476297	476297	+	G	G	A	Missense_Mutation	SNP	ENST00000264938.8	exon13	c.C1972T	p.R658W	exonic	ENSG00000066230.12	.	nonsynonymous SNV	ENSG00000066230.12:ENST00000264938.8:exon13:c.C1972T:p.R658W	5p15.33	C3N-02010	.	.	.	.	.	.	.	.	.	17.20	D	D	D	P	D	D	M	T	D	0.853	D	D	D	0.621	0.450	0.750	0.863	T	D	D	D	D	D	4.255	29.200	0.999	D	D	0.339	3.989	0.250	3.438	1.000	0.741	0.644	0.000	0.601	.	4.750	1.430	2.520	0.119	0.614	1.000	0.992	0.995	835	.	.	.	ID=COSV53800318;OCCURENCE=1(large_intestine),1(prostate)	SLC9A3	408	1	360	58	0.138755980861244	TRUE	TRUE
ENSG00000170561.13	.	BCM	GRCh38.p13	chr5	2749690	2749690	+	G	G	A	Missense_Mutation	SNP	ENST00000302057.6	exon2	c.C347T	p.A116V	exonic	ENSG00000170561.13	.	nonsynonymous SNV	ENSG00000170561.13:ENST00000302057.6:exon2:c.C347T:p.A116V	5p15.33	C3N-02010	.	.	.	.	.	.	.	.	.	17.20	D	D	D	P	D	D	M	D	D	0.805	D	D	D	0.616	0.392	0.876	2.622	T	T	D	D	D	D	4.368	31	0.999	D	D	0.787	8.524	0.763	9.111	1.000	0.733	0.574	0.601	0.639	.	4.850	4.850	9.551	1.172	0.672	1.000	1.000	0.998	946	Homeobox_domain	.	.	.	IRX2	304	0	180	82	0.312977099236641	TRUE	TRUE
ENSG00000205359.10	.	BCM	GRCh38.p13	chr5	102373434	102373434	+	C	C	T	Missense_Mutation	SNP	ENST00000506729.6	exon13	c.G2078A	p.R693H	exonic	ENSG00000205359.10	.	nonsynonymous SNV	ENSG00000205359.10:ENST00000506729.6:exon13:c.G2078A:p.R693H	5q21.1	C3N-02010	0.0001	0.0002	0	0	0.0002	0.0002	0	0	rs143214362	0.20	T	T	B	B	N	N	N	T	N	0.132	T	T	T	0.040	.	0.085	0.134	T	T	T	T	T	T	-1.520	0.001	0.329	N	N	-1.916	0.014	-1.994	0.014	0.000	0.487	0.574	0.574	0.564	.	3.070	-5.960	-5.298	-1.487	-1.710	0.000	0.000	0.000	253	.	.	.	ID=COSV65813613;OCCURENCE=2(central_nervous_system)	SLCO6A1	74	0	72	5	0.0649350649350649	TRUE	NA
ENSG00000113108.19	.	BCM	GRCh38.p13	chr5	140563900	140563900	+	T	T	C	Missense_Mutation	SNP	ENST00000357560.8	exon2	c.A65G	p.D22G	exonic	ENSG00000113108.19	.	nonsynonymous SNV	ENSG00000113108.19:ENST00000357560.8:exon2:c.A65G:p.D22G	5q31.3	C3N-02010	.	.	.	.	.	.	.	.	.	13.20	D	T	D	D	D	D	L	T	D	0.836	T	T	D	0.429	0.429	0.798	1.048	T	T	D	D	D	D	4.418	31	0.998	D	D	0.551	5.454	0.578	5.964	1.000	0.733	0.522	0.601	0.581	.	5.130	5.130	7.835	1.138	0.665	1.000	0.992	0.872	216	.	.	.	.	APBB3	120	1	80	33	0.292035398230089	TRUE	TRUE
ENSG00000137261.14	.	BCM	GRCh38.p13	chr6	24588660	24588660	+	-	NA	G	Nonsense_Mutation	SNP	ENST00000378214.8	exon4	c.926dupC	p.S310*	exonic	ENSG00000137261.14	.	stopgain	ENSG00000137261.14:ENST00000378214.8:exon4:c.926dupC:p.S310*	6p22.3	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KIAA0319	NA	NA	NA	NA	NA	NA	NA
ENSG00000112763.17	.	BCM	GRCh38.p13	chr6	26459485	26459485	+	G	G	C	Missense_Mutation	SNP	ENST00000312541.10	exon3	c.G87C	p.Q29H	exonic	ENSG00000112763.17	.	nonsynonymous SNV	ENSG00000112763.17:ENST00000312541.10:exon3:c.G87C:p.Q29H	6p22.2	C3N-02010	.	.	.	.	.	.	.	.	.	8.20	T	D	P	B	D	D	M	T	D	0.291	T	T	D	0.427	0.687	0.880	0.151	T	T	T	T	T	D	1.527	15.910	0.969	D	N	-0.089	2.211	-0.163	1.878	1.000	0.722	0.686	0.644	0.735	.	3.120	2.230	0.402	1.151	0.618	0.955	0.841	0.238	654	Immunoglobulin-like_domain	.	.	.	BTN2A1	113	0	101	10	0.0900900900900901	NA	TRUE
ENSG00000112763.17	.	BCM	GRCh38.p13	chr6	26459531	26459531	+	G	G	A	Missense_Mutation	SNP	ENST00000312541.10	exon3	c.G133A	p.E45K	exonic	ENSG00000112763.17	.	nonsynonymous SNV	ENSG00000112763.17:ENST00000312541.10:exon3:c.G133A:p.E45K	6p22.2	C3N-02010	.	.	.	.	.	.	.	.	.	9.20	D	D	D	D	N	D	M	T	N	0.297	T	T	T	0.180	0.498	0.524	0.389	T	T	T	T	D	D	3.456	24.600	0.999	D	N	0.286	3.706	0.131	2.865	1.000	0.722	0.686	0.644	0.735	.	3.120	3.120	1.811	1.151	0.618	0.903	0.273	0.164	654	Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	BTN2A1	183	0	194	29	0.130044843049327	TRUE	TRUE
ENSG00000181220.17	.	BCM	GRCh38.p13	chr7	149475052	149475052	+	C	C	T	Missense_Mutation	SNP	ENST00000340622.8	exon7	c.G1267A	p.E423K	exonic	ENSG00000181220.17	.	nonsynonymous SNV	ENSG00000181220.17:ENST00000340622.8:exon7:c.G1267A:p.E423K	7q36.1	C3N-02010	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	U	N	N	T	N	0.104	T	T	T	0.066	0.462	0.340	0.683	T	T	T	T	T	T	1.124	13.000	0.874	N	N	-0.819	0.627	-0.727	0.861	0.976	0.658	0.577	0.660	0.636	.	4.430	3.550	1.773	0.125	0.599	0.224	0.883	0.944	934	.	.	.	.	ZNF746	108	0	82	31	0.274336283185841	TRUE	TRUE
ENSG00000107105.15	.	BCM	GRCh38.p13	chr9	23762020	23762020	+	C	C	T	Missense_Mutation	SNP	ENST00000397312.7	exon2	c.G215A	p.R72K	exonic	ENSG00000107105.15	.	nonsynonymous SNV	ENSG00000107105.15:ENST00000397312.7:exon2:c.G215A:p.R72K	9p21.3	C3N-02010	.	.	.	.	.	.	.	.	.	13.20	D	D	P	B	D	D	L	T	D	0.842	T	T	D	0.262	0.642	0.849	1.146	D	T	D	D	D	D	3.060	23.500	0.994	D	D	0.335	3.967	0.478	4.966	1.000	0.563	0.574	0.609	0.621	.	5.920	5.920	6.156	1.026	0.549	1.000	1.000	0.999	809	RNA_recognition_motif_domain;Splicing_factor_ELAV/Hu,_RNA_recognition_motif_1	.	.	.	ELAVL2	147	0	63	29	0.315217391304348	TRUE	NA
ENSG00000197969.14	.	BCM	GRCh38.p13	chr9	77213241	77213241	+	G	G	A	Missense_Mutation	SNP	ENST00000360280.8	exon9	c.G623A	p.R208Q	exonic	ENSG00000197969.14	.	nonsynonymous SNV	ENSG00000197969.14:ENST00000360280.8:exon9:c.G623A:p.R208Q	9q21.2	C3N-02010	0.0002	0	0.0007	0.0019	0	0	0	0.0001	rs201208791	5.20	T	T	D	P	D	D	L	T	N	0.254	T	T	T	0.145	0.488	0.503	0.155	T	T	T	T	T	D	2.239	21.200	0.973	D	N	-0.319	1.568	-0.278	1.610	0.910	0.732	0.709	0.651	0.728	.	5.950	2.150	3.538	-1.073	-1.485	1.000	0.975	0.948	760	Vacuolar_protein_sorting-associated_protein_13,_second_N-terminal_domain	.	.	.	VPS13A	162	0	71	34	0.323809523809524	TRUE	NA
ENSG00000138308.6	.	BCM	GRCh38.p13	chr10	72954651	72954651	+	A	A	G	Missense_Mutation	SNP	ENST00000373032.4	exon1	c.T35C	p.L12P	exonic	ENSG00000138308.6	.	nonsynonymous SNV	ENSG00000138308.6:ENST00000373032.4:exon1:c.T35C:p.L12P	10q22.1	C3N-02010	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	D	D	M	.	N	0.753	T	T	T	0.674	0.865	0.408	0.472	T	T	D	D	D	T	4.075	27.500	0.999	D	D	0.618	6.107	0.586	6.047	1.000	0.487	0.574	0.492	0.530	.	5.650	5.650	5.810	1.207	0.756	1.000	0.965	0.883	935	.	.	.	.	PLA2G12B	223	1	160	24	0.130434782608696	TRUE	TRUE
ENSG00000183389.5	.	BCM	GRCh38.p13	chr11	6002551	6002551	+	C	C	T	Missense_Mutation	SNP	ENST00000641156.1	exon3	c.G442A	p.V148M	exonic	ENSG00000183389.5	.	nonsynonymous SNV	ENSG00000183389.5:ENST00000641156.1:exon3:c.G442A:p.V148M	11p15.4	C3N-02010	2.474e-05	0	0	0	0	1.5e-05	0	0.0001	rs764719331	1.20	D	T	P	B	U	N	L	T	N	0.094	T	T	T	0.071	0.619	0.237	0.217	T	T	T	T	T	T	0.262	3.849	0.980	N	N	-0.703	0.808	-0.892	0.631	0.000	0.487	0.574	0.547	0.564	.	3.590	-1.620	-1.897	0.125	0.599	0.000	0.048	0.205	808	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58110383;OCCURENCE=1(urinary_tract)	OR56A4	247	1	179	63	0.260330578512397	TRUE	TRUE
ENSG00000149054.16	.	BCM	GRCh38.p13	chr11	6956253	6956253	+	C	C	G	Missense_Mutation	SNP	ENST00000278319.10	exon7	c.C1276G	p.Q426E	exonic	ENSG00000149054.16	.	nonsynonymous SNV	ENSG00000149054.16:ENST00000278319.10:exon7:c.C1276G:p.Q426E	11p15.4	C3N-02010	.	.	.	.	.	.	.	.	.	5.20	D	D	P	B	N	D	L	T	N	0.148	T	T	T	0.155	0.603	0.698	0.025	T	T	T	T	D	D	1.923	18.670	0.987	N	N	-0.374	1.440	-0.389	1.393	0.889	0.707	0.670	0.725	0.655	.	4.850	2.930	0.491	-0.042	-0.224	0.173	0.994	0.965	769	Zinc_finger_C2H2-type	.	.	.	ZNF215	161	0	81	34	0.295652173913043	TRUE	TRUE
ENSG00000235718.9	.	BCM	GRCh38.p13	chr11	119346276	119346276	+	C	C	T	Nonsense_Mutation	SNP	ENST00000619721.6	exon2	c.G153A	p.W51X	exonic	ENSG00000235718.9	.	stopgain	ENSG00000235718.9:ENST00000619721.6:exon2:c.G153A:p.W51X	11q23.3	C3N-02010	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.630	.	.	.	.	.	.	.	.	.	D	D	.	.	7.303	37	0.995	D	N	0.733	7.614	0.577	5.945	1.000	0.497	0.590	0.547	0.542	.	4.690	4.690	1.471	1.026	0.599	0.909	0.858	0.474	749	.	.	.	.	MFRP	662	1	534	146	0.214705882352941	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245351	25245351	+	C	C	G	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G34C	p.G12R	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G34C:p.G12R	12p12.1	C3N-02010	.	.	.	.	.	.	.	.	rs121913530	16.20	D	D	P	P	D	D	L	T	D	0.927	D	D	D	0.821	0.721	0.943	2.165	D	D	D	D	D	D	3.764	25.700	0.999	D	D	0.678	6.825	0.715	8.034	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497582;OCCURENCE=10(breast),1(peritoneum),1(oesophagus),3(cervix),316(large_intestine),2(central_nervous_system),34(biliary_tract),33(ovary),8(bone),4(NS),1(stomach),33(haematopoietic_and_lymphoid_tissue),1(soft_tissue),11(urinary_tract),911(pancreas),2(gastrointestinal_tract_(site_indeterminate)),5(skin),4(prostate),107(lung),31(thyroid),2(upper_aerodigestive_tract),7(testis),3(small_intestine),4(endometrium)	KRAS	273	1	180	88	0.328358208955224	TRUE	TRUE
ENSG00000174106.3	.	BCM	GRCh38.p13	chr12	65245936	65245936	+	G	G	A	Missense_Mutation	SNP	ENST00000308330.3	exon12	c.G2569A	p.D857N	exonic	ENSG00000174106.3	.	nonsynonymous SNV	ENSG00000174106.3:ENST00000308330.3:exon12:c.G2569A:p.D857N	12q14.3	C3N-02010	.	.	.	.	.	.	.	.	.	12.20	D	D	P	P	D	D	M	T	D	0.679	T	T	T	0.227	0.537	0.736	.	D	D	T	T	D	D	4.470	32	0.999	D	D	0.633	6.274	0.675	7.302	0.999	0.732	0.744	0.710	0.728	.	5.170	5.170	9.326	1.176	0.665	1.000	1.000	0.995	693	MAN1,_RNA_recognition_motif	.	.	.	LEMD3	311	0	331	43	0.114973262032086	TRUE	TRUE
ENSG00000133116.8	.	BCM	GRCh38.p13	chr13	33061126	33061126	+	C	C	A	Missense_Mutation	SNP	ENST00000380099.4	exon4	c.C2047A	p.L683I	exonic	ENSG00000133116.8	.	nonsynonymous SNV	ENSG00000133116.8:ENST00000380099.4:exon4:c.C2047A:p.L683I	13q13.1	C3N-02010	1.651e-05	0.0002	0	0	0	0	0	0	rs372004513	1.20	T	T	B	B	N	N	L	T	N	0.269	T	T	T	0.031	.	0.325	0.161	T	T	T	T	T	T	0.870	10.120	0.873	D	N	-0.978	0.428	-0.970	0.528	0.997	0.554	0.588	0.573	0.613	.	5.810	-1.260	0.658	-1.792	-0.780	0.999	0.001	0.163	546	.	.	.	.	KL	109	1	68	28	0.291666666666667	TRUE	NA
ENSG00000174015.10	.	BCM	GRCh38.p13	chr13	45714001	45714001	+	G	G	A	Missense_Mutation	SNP	ENST00000310521.6	exon3	c.G976A	p.A326T	exonic	ENSG00000174015.10	.	nonsynonymous SNV	ENSG00000174015.10:ENST00000310521.6:exon3:c.G976A:p.A326T	13q14.13	C3N-02010	0	0	0	0	0	0	0	0	rs540448583	2.20	T	T	B	B	N	N	L	T	N	0.085	T	T	D	0.043	0.332	0.193	0.335	T	T	T	T	T	T	0.927	10.730	0.957	D	N	-0.910	0.507	-0.881	0.646	0.073	0.403	0.578	0.578	0.563	.	4.900	1.220	1.292	-0.132	-0.129	0.797	0.017	0.059	717	.	.	.	ID=COSV60118895;OCCURENCE=1(pancreas)	CBY2	60	0	42	5	0.106382978723404	NA	TRUE
ENSG00000197616.12	.	BCM	GRCh38.p13	chr14	23389665	23389665	+	C	C	T	Missense_Mutation	SNP	ENST00000405093.8	exon27	c.G3787A	p.V1263M	exonic	ENSG00000197616.12	.	nonsynonymous SNV	ENSG00000197616.12:ENST00000405093.8:exon27:c.G3787A:p.V1263M	14q11.2	C3N-02010	4.119e-05	0.0003	0	0	0	2.997e-05	0	0	rs375819633	1.19	T	T	B	B	.	N	N	T	N	0.167	T	T	D	0.204	.	0.599	0.255	T	T	T	T	T	T	-1.923	0.001	0.877	N	N	-2.318	0.002	-2.395	0.002	1.000	0.497	0.590	0.578	0.613	.	4.820	-9.630	-2.027	-4.344	-4.235	0.000	0.007	0.028	368	Myosin_tail	.	.	.	MYH6	563	0	415	169	0.289383561643836	TRUE	TRUE
ENSG00000066735.14	.	BCM	GRCh38.p13	chr14	104171855	104171855	+	G	G	A	Missense_Mutation	SNP	ENST00000423312.6	exon6	c.G1246A	p.A416T	exonic	ENSG00000066735.14	.	nonsynonymous SNV	ENSG00000066735.14:ENST00000423312.6:exon6:c.G1246A:p.A416T	14q32.33	C3N-02010	.	.	.	.	.	.	.	.	.	2.19	D	T	P	B	.	N	L	T	N	0.066	T	T	D	0.205	.	0.937	0.085	T	T	T	T	T	T	1.013	11.780	0.982	N	N	-0.872	0.556	-0.966	0.532	1.000	0.742	0.547	0.775	0.605	.	3.450	0.403	1.235	-0.780	-0.716	0.005	0.005	0.170	553	Kinesin_motor_domain	.	.	.	KIF26A	223	0	241	90	0.27190332326284	TRUE	NA
ENSG00000180357.9	.	BCM	GRCh38.p13	chr15	64674331	64674331	+	G	G	A	Missense_Mutation	SNP	ENST00000326648.4	exon4	c.G1477A	p.V493I	exonic	ENSG00000180357.9	.	nonsynonymous SNV	ENSG00000180357.9:ENST00000326648.4:exon4:c.G1477A:p.V493I	15q22.31	C3N-02010	0.0005	9.621e-05	8.637e-05	0.0012	0.0003	0.0004	0	0.0008	rs200890644	4.20	T	T	B	B	D	D	N	T	N	0.162	T	T	T	0.028	.	0.043	0.228	T	T	T	T	T	D	2.068	19.770	0.976	D	N	0.007	2.534	0.213	3.248	1.000	0.707	0.725	0.725	0.714	.	5.610	5.610	4.519	1.176	0.676	1.000	0.998	0.989	306	.	.	.	ID=COSV58583491;OCCURENCE=3(central_nervous_system),2(stomach),1(kidney),1(prostate),1(lung)	ZNF609	215	0	116	57	0.329479768786127	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675088	7675088	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon5	c.G524A	p.R175H	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon5:c.G524A:p.R175H	17p13.1	C3N-02010	8.243e-06	0	0	0	0	1.499e-05	0	0	rs28934578	19.20	D	D	D	D	D	A	M	D	D	0.938	D	D	D	0.922	0.986	0.997	1.101	T	D	D	D	D	D	2.987	23.400	0.999	D	D	0.740	7.720	0.711	7.954	1.000	0.722	0.698	0.698	0.735	.	5.410	5.410	6.163	1.026	0.599	1.000	0.996	0.919	434	p53,_DNA-binding_domain	.	.	ID=COSV52661038;OCCURENCE=13(salivary_gland),172(breast),8(penis),1(peritoneum),14(liver),118(oesophagus),6(adrenal_gland),1(meninges),5(cervix),604(large_intestine),116(central_nervous_system),23(biliary_tract),94(ovary),9(vulva),2(pleura),5(bone),6(NS),124(stomach),74(haematopoietic_and_lymphoid_tissue),14(soft_tissue),21(kidney),38(urinary_tract),75(pancreas),10(skin),28(prostate),47(lung),14(thyroid),109(upper_aerodigestive_tract),1(testis),1(eye),3(small_intestine),31(endometrium)	TP53	342	0	190	118	0.383116883116883	TRUE	TRUE
ENSG00000129646.14	.	BCM	GRCh38.p13	chr17	76275858	76275858	+	G	G	A	Missense_Mutation	SNP	ENST00000262765.10	exon18	c.C4945T	p.R1649W	exonic	ENSG00000129646.14	.	nonsynonymous SNV	ENSG00000129646.14:ENST00000262765.10:exon18:c.C4945T:p.R1649W	17q25.1	C3N-02010	8.4e-06	0	0	0	0	0	0	6.076e-05	rs748067581	10.19	D	D	D	D	.	D	L	T	D	0.628	T	T	D	0.128	0.105	0.102	0.696	T	T	T	T	D	D	3.615	25.100	0.996	D	N	0.078	2.800	0.039	2.499	1.000	0.646	0.551	0.645	0.528	.	3.880	3.880	1.246	1.083	0.676	0.911	0.892	0.179	964	.	.	.	.	QRICH2	249	0	124	67	0.350785340314136	TRUE	NA
ENSG00000141452.10	.	BCM	GRCh38.p13	chr18	23527860	23527860	+	G	G	A	Missense_Mutation	SNP	ENST00000269221.8	exon14	c.G1255A	p.E419K	exonic	ENSG00000141452.10	.	nonsynonymous SNV	ENSG00000141452.10:ENST00000269221.8:exon14:c.G1255A:p.E419K	18q11.2	C3N-02010	.	.	.	.	.	.	.	.	.	9.17	D	T	P	B	D	D	.	.	N	0.677	T	T	T	0.198	0.401	0.134	0.598	.	T	D	D	D	D	3.145	23.700	0.998	D	D	0.282	3.687	0.423	4.528	1.000	0.732	0.702	0.744	0.714	.	5.340	5.340	9.564	1.176	0.676	1.000	0.994	0.994	850	.	.	.	.	RMC1	173	0	141	53	0.27319587628866	TRUE	TRUE
ENSG00000181143.15	.	BCM	GRCh38.p13	chr19	8959941	8959941	+	C	C	T	Missense_Mutation	SNP	ENST00000397910.8	exon3	c.G16829A	p.R5610Q	exonic	ENSG00000181143.15	.	nonsynonymous SNV	ENSG00000181143.15:ENST00000397910.8:exon3:c.G16829A:p.R5610Q	19p13.2	C3N-02010	1.66e-05	0	0	0	0	1.501e-05	0	6.058e-05	rs761072024	0.15	T	T	.	.	.	N	.	T	N	0.071	T	T	T	0.077	0.254	0.048	.	T	.	T	T	T	T	-0.420	0.175	0.367	N	N	-1.047	0.356	-1.258	0.238	0.000	0.554	0.574	0.618	0.564	.	1.460	-2.920	-3.305	-2.978	-0.486	0.000	0.000	0.001	905	.	.	.	ID=COSV67470593;OCCURENCE=1(liver),1(oesophagus),1(large_intestine)	MUC16	292	0	129	97	0.429203539823009	TRUE	TRUE
ENSG00000089050.16	.	BCM	GRCh38.p13	chr20	18489768	18489768	+	G	G	A	Missense_Mutation	SNP	ENST00000337227.9	exon5	c.C557T	p.A186V	exonic	ENSG00000089050.16	.	nonsynonymous SNV	ENSG00000089050.16:ENST00000337227.9:exon5:c.C557T:p.A186V	20p11.23	C3N-02010	.	.	.	.	.	.	.	.	.	3.19	D	D	B	B	N	N	L	.	N	0.055	T	T	T	0.127	0.433	0.262	0.151	T	T	T	T	T	T	1.929	18.710	0.986	D	N	-0.654	0.892	-0.642	0.984	0.015	0.707	0.725	0.609	0.714	.	4.880	-1.150	1.076	0.161	0.671	0.945	0.918	0.858	526	.	.	.	.	RBBP9	84	0	54	30	0.357142857142857	TRUE	TRUE
ENSG00000154654.15	.	BCM	GRCh38.p13	chr21	21335590	21335590	+	G	G	T	Missense_Mutation	SNP	ENST00000400546.6	exon7	c.G823T	p.D275Y	exonic	ENSG00000154654.15	.	nonsynonymous SNV	ENSG00000154654.15:ENST00000400546.6:exon7:c.G823T:p.D275Y	21q21.1	C3N-02010	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.970	D	D	D	0.884	0.709	0.857	0.456	T	D	D	D	D	D	4.227	28.900	0.995	D	D	0.838	9.566	0.740	8.582	0.973	0.554	0.574	0.574	0.621	.	5.320	5.320	7.220	1.155	0.618	1.000	0.737	0.641	999	Immunoglobulin_V-set_domain;Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_I-set;Immunoglobulin_subtype	.	.	.	NCAM2	123	0	53	23	0.302631578947368	TRUE	TRUE
ENSG00000206203.5	.	BCM	GRCh38.p13	chr22	19131739	19131739	+	C	C	T	Missense_Mutation	SNP	ENST00000399635.4	exon1	c.C340T	p.R114C	exonic	ENSG00000206203.5	.	nonsynonymous SNV	ENSG00000206203.5:ENST00000399635.4:exon1:c.C340T:p.R114C	22q11.21	C3N-02010	0.0002	0.0016	0	0	0	1.5e-05	0	6.06e-05	rs142708655	13.20	D	D	D	P	D	D	M	D	D	0.296	D	D	D	0.545	.	0.946	0.589	T	T	T	D	T	D	3.014	23.400	0.999	N	N	0.305	3.805	0.228	3.324	1.000	0.000	0.573	0.508	0.492	.	5.480	5.480	1.581	1.008	0.599	0.030	0.650	0.534	878	Protein_kinase_domain	.	.	ID=COSV52818638;OCCURENCE=1(oesophagus),1(central_nervous_system)	TSSK2	173	0	129	45	0.258620689655172	TRUE	TRUE
ENSG00000183762.12	.	BCM	GRCh38.p13	chr22	29140335	29140335	+	G	G	T	Missense_Mutation	SNP	ENST00000407188.5	exon8	c.G1222T	p.V408L	exonic	ENSG00000183762.12	.	nonsynonymous SNV	ENSG00000183762.12:ENST00000407188.5:exon8:c.G1222T:p.V408L	22q12.1	C3N-02010	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	D	N	T	N	0.115	T	T	T	0.089	0.467	0.294	0.172	T	T	T	T	T	T	1.184	13.510	0.799	N	N	-1.012	0.391	-0.938	0.570	1.000	0.653	0.574	0.676	0.616	.	5.530	-2.540	0.424	1.176	0.676	0.159	1.000	1.000	506	.	.	.	.	KREMEN1	200	0	175	44	0.200913242009132	TRUE	TRUE
ENSG00000056972.20	.	BCM	GRCh38.p13	chr6	111567623	111567623	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000056972.20	ENST00000340026.10:exon7:c.1386+1G>A	.	.	6q21	C3N-02010	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.527	34	0.995	D	.	1.167	21.118	1.031	20.850	1.000	0.322	0.319	0.084	0.127	0.990	5.760	5.760	6.309	1.026	0.599	1.000	1.000	0.980	426	.	.	.	.	TRAF3IP2	133	0	107	23	0.176923076923077	TRUE	TRUE
ENSG00000033122.21	.	BCM	GRCh38.p13	chr1	70023191	70023191	+	G	G	T	Silent	SNP	ENST00000651989.2	exon17	c.G1611T	p.L537L	exonic	ENSG00000033122.21	.	synonymous SNV	ENSG00000033122.21:ENST00000651989.2:exon17:c.G1611T:p.L537L	1p31.1	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRRC7	49	0	43	24	0.358208955223881	TRUE	TRUE
ENSG00000096264.14	.	BCM	GRCh38.p13	chr6	41336202	41336202	+	G	G	A	Silent	SNP	ENST00000373089.10	exon2	c.G168A	p.K56K	exonic	ENSG00000096264.14	.	synonymous SNV	ENSG00000096264.14:ENST00000373089.10:exon2:c.G168A:p.K56K	6p21.1	C3N-02010	.	.	.	.	.	.	.	.	rs865913443	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NCR2	284	0	465	82	0.149908592321755	TRUE	NA
ENSG00000004846.16	.	BCM	GRCh38.p13	chr7	20643310	20643310	+	T	T	A	Silent	SNP	ENST00000404938.6	exon6	c.T441A	p.V147V	exonic	ENSG00000004846.16	.	synonymous SNV	ENSG00000004846.16:ENST00000404938.6:exon6:c.T441A:p.V147V	7p21.1	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABCB5	127	0	85	36	0.297520661157025	TRUE	TRUE
ENSG00000164867.11	.	BCM	GRCh38.p13	chr7	150999226	150999226	+	C	C	T	Silent	SNP	ENST00000297494.8	exon9	c.C993T	p.Y331Y	exonic	ENSG00000164867.11	.	synonymous SNV	ENSG00000164867.11:ENST00000297494.8:exon9:c.C993T:p.Y331Y	7q36.1	C3N-02010	8.424e-06	0	0	0	0	1.543e-05	0	0	rs370490675	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52489831;OCCURENCE=2(large_intestine),1(urinary_tract),1(pancreas)	NOS3	93	0	87	37	0.298387096774194	TRUE	TRUE
ENSG00000108018.15	.	BCM	GRCh38.p13	chr10	106629350	106629350	+	G	G	A	Silent	SNP	ENST00000263054.10	exon19	c.C2514T	p.G838G	exonic	ENSG00000108018.15	.	synonymous SNV	ENSG00000108018.15:ENST00000263054.10:exon19:c.C2514T:p.G838G	10q25.1	C3N-02010	1.659e-05	0	0	0	0	3.011e-05	0	0	rs144932995	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53883534;OCCURENCE=1(central_nervous_system),1(stomach),1(endometrium)	SORCS1	102	0	79	16	0.168421052631579	TRUE	TRUE
ENSG00000172572.6	.	BCM	GRCh38.p13	chr12	20369503	20369503	+	G	G	C	Silent	SNP	ENST00000359062.3	exon1	c.G219C	p.L73L	exonic	ENSG00000172572.6	.	synonymous SNV	ENSG00000172572.6:ENST00000359062.3:exon1:c.G219C:p.L73L	12p12.2	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDE3A	150	0	111	52	0.319018404907975	TRUE	TRUE
ENSG00000139116.18	.	BCM	GRCh38.p13	chr12	39301632	39301632	+	C	C	T	Silent	SNP	ENST00000361418.9	exon37	c.G4779A	p.V1593V	exonic	ENSG00000139116.18	.	synonymous SNV	ENSG00000139116.18:ENST00000361418.9:exon37:c.G4779A:p.V1593V	12q12	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62775337;OCCURENCE=1(biliary_tract)	KIF21A	164	0	82	55	0.401459854014599	TRUE	TRUE
ENSG00000270123.4	.	BCM	GRCh38.p13	chr5	136080526	136080526	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000270123.4;ENSG00000278815.1	.	.	.	5q31.1	C3N-02010	.	.	.	.	.	.	.	.	rs954556926	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VTRNA2-1	131	0	84	34	0.288135593220339	TRUE	NA
ENSG00000109881.17	.	BCM	GRCh38.p13	chr11	27350270	27350270	+	T	T	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000109881.17	.	.	.	11p14.1	C3N-02010	.	.	.	.	.	.	.	.	.	1.16	D	T	B	B	.	N	.	T	N	0.181	T	T	T	0.026	0.242	0.122	.	.	.	T	T	T	T	0.404	5.475	0.716	N	N	-1.010	0.394	-1.105	0.371	1.000	0.554	0.588	0.547	0.621	.	4.190	0.056	0.019	0.200	-0.194	0.001	0.006	0.063	623	.	.	.	.	CCDC34	72	1	57	6	0.0952380952380952	NA	TRUE
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65505172	65505175	+	TTTA	TTTA	-	RNA	DEL	NA	NA	NA	NA	ncRNA_intronic	ENSG00000251562.8	.	.	.	11q13.1	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	139	0	92	30	0.245901639344262	TRUE	NA
ENSG00000204529.4	.	BCM	GRCh38.p13	chr11	76719522	76719522	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000204529.4	.	.	.	11q13.5	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GUCY2EP	52	3	29	8	0.216216216216216	TRUE	NA
ENSG00000258167.1	.	BCM	GRCh38.p13	chr12	40429573	40429573	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000258167.1	.	.	.	12q12	C3N-02010	0.0028	0	0	0	0	0.0016	0	0.0053	rs79310720	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC107023.1	116	0	72	25	0.257731958762887	TRUE	NA
ENSG00000223611.5	.	BCM	GRCh38.p13	chrX	24311635	24311635	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000223611.5	.	.	.	Xp22.11	C3N-02010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUPT20HL2	224	0	93	45	0.326086956521739	TRUE	NA
ENSG00000134262.13	.	BCM	GRCh38.p13	chr1	113897901	113897901	+	T	T	A	Missense_Mutation	SNP	ENST00000369569.6	exon7	c.A1241T	p.Q414L	exonic	ENSG00000134262.13	.	nonsynonymous SNV	ENSG00000134262.13:ENST00000369569.6:exon7:c.A1241T:p.Q414L	1p13.2	C3L-01031	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	D	D	M	T	D	0.716	T	T	D	0.463	0.528	0.508	0.524	T	T	T	T	D	D	4.145	28.200	0.996	D	D	0.614	6.072	0.643	6.814	1.000	0.706	0.725	0.710	0.714	.	5.510	5.510	7.375	1.138	0.665	1.000	1.000	0.998	576	Clathrin/coatomer_adaptor,_adaptin-like,_N-terminal	.	.	.	AP4B1	374	0	750	274	0.267578125	TRUE	TRUE
ENSG00000117691.10	.	BCM	GRCh38.p13	chr1	212445866	212445866	+	G	G	C	Missense_Mutation	SNP	ENST00000366988.5	exon4	c.G379C	p.E127Q	exonic	ENSG00000117691.10	.	nonsynonymous SNV	ENSG00000117691.10:ENST00000366988.5:exon4:c.G379C:p.E127Q	1q32.3	C3L-01031	.	.	.	.	.	.	.	.	.	5.20	T	D	B	B	N	N	L	T	N	0.061	T	T	D	0.255	0.414	0.846	0.050	T	T	T	T	D	T	2.782	23.000	0.990	D	D	-0.018	2.447	0.134	2.877	0.114	0.706	0.725	0.710	0.613	.	4.920	4.920	5.141	1.176	0.618	1.000	0.918	0.861	761	Cytochrome_b5-like_heme/steroid_binding_domain	.	.	.	NENF	221	0	585	36	0.0579710144927536	TRUE	TRUE
ENSG00000084774.14	.	BCM	GRCh38.p13	chr2	27242890	27242890	+	G	G	C	Missense_Mutation	SNP	ENST00000264705.9	exon42	c.G6397C	p.E2133Q	exonic	ENSG00000084774.14	.	nonsynonymous SNV	ENSG00000084774.14:ENST00000264705.9:exon42:c.G6397C:p.E2133Q	2p23.3	C3L-01031	.	.	.	.	.	.	.	.	.	14.20	T	T	D	D	D	D	M	D	N	0.774	T	T	D	0.759	0.513	0.875	1.257	T	D	D	D	D	D	3.571	24.900	0.998	D	D	0.520	5.196	0.584	6.023	1.000	0.707	0.702	0.702	0.714	.	5.280	5.280	9.118	1.157	0.654	1.000	0.992	0.633	251	Aspartate/ornithine_carbamoyltransferase,_Asp/Orn-binding_domain	.	.	.	CAD	161	0	572	37	0.0607553366174056	TRUE	TRUE
ENSG00000124383.9	.	BCM	GRCh38.p13	chr2	71141280	71141280	+	G	G	A	Missense_Mutation	SNP	ENST00000244230.7	exon7	c.G1357A	p.E453K	exonic	ENSG00000124383.9	.	nonsynonymous SNV	ENSG00000124383.9:ENST00000244230.7:exon7:c.G1357A:p.E453K	2p13.3	C3L-01031	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.585	T	T	D	0.229	0.511	0.472	0.606	T	T	T	T	D	D	4.341	29.900	0.999	D	D	0.596	5.879	0.608	6.331	1.000	0.707	0.725	0.725	0.714	.	5.520	5.520	5.738	0.225	-0.165	1.000	0.998	0.979	872	.	.	.	.	MPHOSPH10	142	0	143	40	0.218579234972678	TRUE	TRUE
ENSG00000172318.5	.	BCM	GRCh38.p13	chr2	167869999	167869999	+	C	C	A	Missense_Mutation	SNP	ENST00000392690.3	exon1	c.C960A	p.S320R	exonic	ENSG00000172318.5	.	nonsynonymous SNV	ENSG00000172318.5:ENST00000392690.3:exon1:c.C960A:p.S320R	2q24.3	C3L-01031	.	.	.	.	.	.	.	.	.	4.19	T	T	P	B	N	D	N	T	N	0.581	T	T	T	0.091	0.355	0.508	0.636	D	T	T	T	D	T	1.999	19.250	0.982	D	.	0.173	3.186	0.298	3.704	1.000	0.651	0.574	0.651	0.564	.	5.540	4.640	3.756	1.026	0.599	1.000	1.000	0.999	753	.	.	.	.	B3GALT1	71	0	117	43	0.26875	TRUE	TRUE
ENSG00000188738.15	.	BCM	GRCh38.p13	chr2	185793789	185793789	+	G	G	A	Missense_Mutation	SNP	ENST00000424728.6	exon16	c.G6653A	p.R2218K	exonic	ENSG00000188738.15	.	nonsynonymous SNV	ENSG00000188738.15:ENST00000424728.6:exon16:c.G6653A:p.R2218K	2q32.1	C3L-01031	.	.	.	.	.	.	.	.	.	0.16	T	T	.	.	.	N	N	T	N	0.035	T	T	T	0.033	.	0.081	.	T	T	T	T	T	T	0.010	1.396	0.588	N	.	-1.328	0.150	-1.361	0.172	0.956	0.487	0.547	0.574	0.564	.	5.530	-1.400	-0.232	-0.106	-0.124	0.000	0.015	0.342	771	.	.	.	.	FSIP2	153	2	235	37	0.136029411764706	TRUE	TRUE
ENSG00000196950.14	.	BCM	GRCh38.p13	chr2	195680217	195680217	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000359634.10	exon2	c.176dupA	p.Y62Ifs*4	exonic	ENSG00000196950.14	.	frameshift insertion	ENSG00000196950.14:ENST00000359634.10:exon2:c.176dupA:p.Y62Ifs*4	2q32.3	C3L-01031	8.449e-06	0	0	0	0	1.536e-05	0	0	rs771462597	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC39A10	NA	NA	NA	NA	NA	NA	NA
ENSG00000085982.13	.	BCM	GRCh38.p13	chr2	233477445	233477445	+	G	G	A	Missense_Mutation	SNP	ENST00000251722.10	exon32	c.C3655T	p.R1219W	exonic	ENSG00000085982.13	.	nonsynonymous SNV	ENSG00000085982.13:ENST00000251722.10:exon32:c.C3655T:p.R1219W	2q37.1	C3L-01031	6.744e-05	0	0.0002	0	0	6.114e-05	0.0011	6.129e-05	rs200793850	5.20	D	D	D	P	N	N	M	T	N	0.475	T	T	T	0.096	.	0.421	0.245	T	T	T	T	T	D	3.569	24.900	0.998	N	N	-0.118	2.119	-0.303	1.558	0.999	0.732	0.744	0.571	0.684	.	4.700	2.820	1.474	0.161	0.676	0.289	0.001	0.040	929	.	.	.	.	USP40	433	0	1172	77	0.0616493194555644	TRUE	NA
ENSG00000154743.18	.	BCM	GRCh38.p13	chr3	12489922	12489922	+	G	G	A	Missense_Mutation	SNP	ENST00000284995.11	exon2	c.G122A	p.R41H	exonic	ENSG00000154743.18	.	nonsynonymous SNV	ENSG00000154743.18:ENST00000284995.11:exon2:c.G122A:p.R41H	3p25.2	C3L-01031	0.0381	0.1732	0.0414	0.0321	0.0112	0.0146	0.0331	0.0601	rs12495784	0.19	T	T	B	B	N	P	L	T	N	0.032	T	T	.	0.050	.	.	0.035	T	T	T	T	T	T	0.249	3.688	0.926	N	N	-1.499	0.081	-1.506	0.106	1.000	0.732	0.744	0.723	0.728	.	5.700	-1.600	-0.262	-2.786	-1.655	0.002	0.001	0.064	808	.	TSEN2	Colon_Transverse;Esophagus_Mucosa;Muscle_Skeletal;Adipose_Visceral_Omentum;Esophagus_Muscularis;Nerve_Tibial	.	TSEN2	453	0	1015	91	0.0822784810126582	TRUE	NA
ENSG00000164077.14	.	BCM	GRCh38.p13	chr3	49929718	49929718	+	C	C	T	Missense_Mutation	SNP	ENST00000296473.7	exon1	c.G169A	p.E57K	exonic	ENSG00000164077.14	.	nonsynonymous SNV	ENSG00000164077.14:ENST00000296473.7:exon1:c.G169A:p.E57K	3p21.31	C3L-01031	.	.	.	.	.	.	.	.	.	0.14	T	T	.	.	.	N	.	.	N	0.085	T	T	T	0.021	.	0.140	0.092	T	.	T	T	T	T	1.469	15.540	0.987	N	N	-1.247	0.196	-1.287	0.218	1.000	0.442	0.522	0.522	0.562	.	5.770	-3.630	-0.454	0.130	-0.176	0.001	0.013	0.027	1	.	.	.	ID=COSV56562816;OCCURENCE=1(skin)	MON1A	250	0	789	55	0.0651658767772512	TRUE	TRUE
ENSG00000164077.14	.	BCM	GRCh38.p13	chr3	49929856	49929856	+	C	C	T	Missense_Mutation	SNP	ENST00000296473.7	exon1	c.G31A	p.E11K	exonic	ENSG00000164077.14	.	nonsynonymous SNV	ENSG00000164077.14:ENST00000296473.7:exon1:c.G31A:p.E11K	3p21.31	C3L-01031	.	.	.	.	.	.	.	.	.	0.14	T	T	.	.	.	N	.	.	N	0.073	T	T	T	0.002	0.279	0.148	0.093	T	.	T	T	T	T	1.038	12.090	0.953	N	N	-1.357	0.136	-1.438	0.134	1.000	0.035	0.179	0.289	0.003	.	4.790	-5.410	-0.114	-0.784	-0.214	0.000	0.001	0.048	1	.	.	.	.	MON1A	275	0	1035	72	0.0650406504065041	TRUE	TRUE
ENSG00000174564.13	.	BCM	GRCh38.p13	chr3	136982213	136982213	+	C	C	T	Missense_Mutation	SNP	ENST00000329582.9	exon3	c.C269T	p.S90L	exonic	ENSG00000174564.13	.	nonsynonymous SNV	ENSG00000174564.13:ENST00000329582.9:exon3:c.C269T:p.S90L	3q22.3	C3L-01031	.	.	.	.	.	.	.	.	.	2.20	T	D	B	B	N	N	L	T	N	0.365	T	T	D	0.132	0.502	0.640	0.228	T	T	T	T	T	T	2.560	22.600	0.992	N	N	-0.287	1.645	-0.255	1.659	0.332	0.615	0.588	0.659	0.528	.	4.910	1.910	1.599	1.026	0.549	0.901	0.606	0.452	715	Fibronectin_type_III	.	.	.	IL20RB	61	0	148	12	0.075	TRUE	TRUE
ENSG00000120756.13	.	BCM	GRCh38.p13	chr3	142711883	142711883	+	C	C	T	Missense_Mutation	SNP	ENST00000457734.7	exon16	c.C1766T	p.S589L	exonic	ENSG00000120756.13	.	nonsynonymous SNV	ENSG00000120756.13:ENST00000457734.7:exon16:c.C1766T:p.S589L	3q23	C3L-01031	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.960	D	D	D	0.976	0.772	0.988	0.730	T	D	D	D	D	D	4.266	29.300	0.999	D	D	1.012	14.299	0.944	15.799	1.000	0.706	0.588	0.710	0.621	.	5.700	5.700	7.905	1.026	0.599	1.000	1.000	0.999	554	Calponin_homology_domain	.	.	ID=COSV61833764;OCCURENCE=1(breast)	PLS1	183	1	412	60	0.127118644067797	TRUE	TRUE
ENSG00000109436.8	.	BCM	GRCh38.p13	chr4	140622680	140622680	+	C	C	T	Missense_Mutation	SNP	ENST00000442267.3	exon21	c.G3316A	p.V1106M	exonic	ENSG00000109436.8	.	nonsynonymous SNV	ENSG00000109436.8:ENST00000442267.3:exon21:c.G3316A:p.V1106M	4q31.21	C3L-01031	8.584e-06	0	0	0	0	0	0	6.687e-05	rs545624117	0.19	T	T	B	B	.	N	N	T	N	0.026	T	T	T	0.029	0.076	0.129	0.491	T	T	T	T	T	T	0.785	9.243	0.921	N	N	-0.947	0.463	-0.973	0.523	0.944	0.707	0.634	0.650	0.714	.	5.350	1.120	-0.032	0.130	-0.176	0.002	0.005	0.070	878	.	.	.	ID=COSV71308588;OCCURENCE=1(large_intestine)	TBC1D9	95	0	216	94	0.303225806451613	TRUE	TRUE
ENSG00000169862.19	.	BCM	GRCh38.p13	chr5	11236707	11236707	+	T	T	C	Missense_Mutation	SNP	ENST00000304623.13	exon10	c.A1745G	p.N582S	exonic	ENSG00000169862.19	.	nonsynonymous SNV	ENSG00000169862.19:ENST00000304623.13:exon10:c.A1745G:p.N582S	5p15.2	C3L-01031	.	.	.	.	.	.	.	.	.	10.20	T	T	D	D	D	D	L	T	D	0.349	T	T	D	0.379	0.526	0.663	1.202	T	T	T	T	D	D	3.776	25.700	0.999	D	D	0.523	5.222	0.582	6.009	1.000	0.693	0.574	0.659	0.564	.	5.810	5.810	6.167	1.138	0.665	1.000	1.000	0.996	925	.	.	.	.	CTNND2	216	0	516	191	0.27015558698727	TRUE	NA
ENSG00000164309.15	.	BCM	GRCh38.p13	chr5	79729873	79729873	+	G	G	A	Missense_Mutation	SNP	ENST00000446378.3	exon2	c.G1108A	p.E370K	exonic	ENSG00000164309.15	.	nonsynonymous SNV	ENSG00000164309.15:ENST00000446378.3:exon2:c.G1108A:p.E370K	5q14.1	C3L-01031	.	.	.	.	.	.	.	.	.	3.20	D	T	P	B	N	N	L	T	N	0.141	T	T	D	0.152	0.200	0.382	0.060	T	T	T	T	D	T	1.691	16.970	0.995	N	N	-0.352	1.490	-0.424	1.329	1.000	0.487	0.574	0.574	0.564	.	5.810	4.940	2.543	0.224	0.676	0.988	0.099	0.272	422	.	.	.	ID=COSV104716739;OCCURENCE=1(skin)	CMYA5	281	0	722	46	0.0598958333333333	TRUE	TRUE
ENSG00000277157.2	.	BCM	GRCh38.p13	chr6	26188958	26188958	+	C	C	A	Missense_Mutation	SNP	ENST00000614247.2	exon1	c.G119T	p.R40L	exonic	ENSG00000277157.2	.	nonsynonymous SNV	ENSG00000277157.2:ENST00000614247.2:exon1:c.G119T:p.R40L	6p22.2	C3L-01031	.	.	.	.	.	.	.	.	.	12.12	.	D	.	.	D	D	.	.	.	0.825	D	D	D	0.741	.	0.366	.	D	.	D	D	D	.	3.811	25.900	0.997	D	D	0.198	3.296	0.185	3.110	1.000	0.025	0.219	0.240	0.250	.	5.320	5.320	5.783	1.026	0.594	1.000	0.313	0.022	675	.	.	.	.	H4C4	189	0	507	36	0.0662983425414365	TRUE	TRUE
ENSG00000273802.2	.	BCM	GRCh38.p13	chr6	26216434	26216434	+	G	G	C	Missense_Mutation	SNP	ENST00000541790.3	exon1	c.C210G	p.I70M	exonic	ENSG00000273802.2	.	nonsynonymous SNV	ENSG00000273802.2:ENST00000541790.3:exon1:c.C210G:p.I70M	6p22.2	C3L-01031	.	.	.	.	.	.	.	.	.	7.15	D	T	.	.	.	N	.	T	D	0.802	T	T	T	0.303	.	0.543	.	D	.	D	T	D	D	2.513	22.400	0.993	D	N	-0.303	1.608	-0.350	1.465	1.000	0.442	0.522	0.522	0.373	.	3.990	1.190	0.884	0.228	-0.113	1.000	0.999	0.596	698	.	.	.	ID=COSV99773400;OCCURENCE=1(cervix)	H2BC8	217	0	346	183	0.34593572778828	TRUE	TRUE
ENSG00000137221.14	.	BCM	GRCh38.p13	chr6	43505505	43505505	+	C	C	A	Missense_Mutation	SNP	ENST00000372445.9	exon11	c.C1324A	p.L442M	exonic	ENSG00000137221.14	.	nonsynonymous SNV	ENSG00000137221.14:ENST00000372445.9:exon11:c.C1324A:p.L442M	6p21.1	C3L-01031	.	.	.	.	.	.	.	.	.	9.19	D	T	D	D	D	D	M	.	N	0.442	T	T	T	0.128	0.219	0.216	0.858	T	T	T	T	D	T	3.272	24.000	0.995	D	D	0.472	4.822	0.412	4.442	1.000	0.719	0.702	0.723	0.714	.	5.560	2.580	3.328	0.130	0.599	1.000	0.508	0.874	225	.	.	.	.	TJAP1	254	1	670	100	0.12987012987013	TRUE	TRUE
ENSG00000180113.16	.	BCM	GRCh38.p13	chr6	46688786	46688786	+	G	G	A	Missense_Mutation	SNP	ENST00000316081.11	exon1	c.G658A	p.V220M	exonic	ENSG00000180113.16	.	nonsynonymous SNV	ENSG00000180113.16:ENST00000316081.11:exon1:c.G658A:p.V220M	6p12.3	C3L-01031	1.721e-05	0.0002	0	0	0	0	0	0	rs139956934	0.20	T	T	B	B	N	N	N	T	N	0.025	T	T	T	0.034	.	0.095	0.029	T	T	T	T	T	T	-1.644	0.001	0.771	N	N	-1.803	0.023	-1.993	0.014	1.000	0.487	0.574	0.578	0.542	.	5.330	-10.700	-6.398	-0.921	-0.113	0.000	0.002	0.010	505	.	.	.	ID=COSV60173801;OCCURENCE=1(large_intestine)	TDRD6	132	0	408	31	0.0706150341685649	TRUE	TRUE
ENSG00000196313.11	.	BCM	GRCh38.p13	chr7	72942917	72942917	+	C	C	G	Missense_Mutation	SNP	ENST00000434423.4	exon11	c.C2924G	p.A975G	exonic	ENSG00000196313.11	.	nonsynonymous SNV	ENSG00000196313.11:ENST00000434423.4:exon11:c.C2924G:p.A975G	7q11.23	C3L-01031	.	.	.	.	.	.	.	.	.	4.20	D	D	P	B	N	N	L	T	N	0.231	T	T	D	0.064	0.164	0.014	.	T	T	T	T	D	T	1.143	13.160	0.968	N	N	-0.430	1.319	-0.609	1.032	0.002	0.672	0.702	0.723	0.636	.	2.330	2.330	2.583	0.946	0.284	0.011	0.009	0.049	441	.	.	.	.	POM121	93	0	256	75	0.226586102719033	NA	TRUE
ENSG00000091656.19	.	BCM	GRCh38.p13	chr8	76863417	76863417	+	G	G	A	Missense_Mutation	SNP	ENST00000651372.2	exon11	c.G9703A	p.E3235K	exonic	ENSG00000091656.19	.	nonsynonymous SNV	ENSG00000091656.19:ENST00000651372.2:exon11:c.G9703A:p.E3235K	8q21.13	C3L-01031	.	.	.	.	.	.	.	.	.	7.16	D	D	.	.	U	D	.	T	N	0.372	T	T	T	0.213	0.461	0.043	0.205	T	.	T	T	D	D	2.828	23.100	0.996	D	D	0.403	4.362	0.477	4.960	1.000	0.638	0.588	0.618	0.668	.	4.710	4.710	9.715	1.176	0.676	1.000	0.072	0.335	795	.	.	.	ID=COSV99261375;OCCURENCE=1(skin)	ZFHX4	289	0	601	33	0.0520504731861199	TRUE	NA
ENSG00000079102.16	.	BCM	GRCh38.p13	chr8	92017273	92017273	+	G	G	C	Missense_Mutation	SNP	ENST00000613302.4	exon5	c.C179G	p.P60R	exonic	ENSG00000079102.16	.	nonsynonymous SNV	ENSG00000079102.16:ENST00000613302.4:exon5:c.C179G:p.P60R	8q21.3	C3L-01031	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.741	T	T	T	0.306	0.441	0.472	1.658	D	D	D	T	D	D	3.901	26.400	0.999	D	D	0.792	8.617	0.823	10.847	1.000	0.732	0.574	0.663	0.728	.	5.660	5.660	8.102	1.172	0.676	1.000	1.000	0.997	531	.	.	.	ID=COSV56158222;OCCURENCE=2(lung)	RUNX1T1	193	0	437	24	0.052060737527115	TRUE	TRUE
ENSG00000122728.6	.	BCM	GRCh38.p13	chr9	32633707	32633707	+	G	G	T	Missense_Mutation	SNP	ENST00000242310.4	exon1	c.C1873A	p.H625N	exonic	ENSG00000122728.6	.	nonsynonymous SNV	ENSG00000122728.6:ENST00000242310.4:exon1:c.C1873A:p.H625N	9p21.1	C3L-01031	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	L	T	D	0.357	T	T	T	0.263	0.452	0.531	0.582	T	T	T	T	D	D	2.729	22.900	0.985	D	N	0.251	3.537	0.081	2.658	0.959	0.638	0.670	0.659	0.568	.	0.633	0.633	4.836	0.310	0.268	1.000	0.857	0.663	835	Transcription_initiation_factor_TFIID_subunit_1,_domain_of_unknown_function	.	.	.	TAF1L	328	0	632	60	0.0867052023121387	NA	TRUE
ENSG00000165282.14	.	BCM	GRCh38.p13	chr9	35091822	35091822	+	G	G	A	Missense_Mutation	SNP	ENST00000378617.4	exon7	c.C2065T	p.R689C	exonic	ENSG00000165282.14	.	nonsynonymous SNV	ENSG00000165282.14:ENST00000378617.4:exon7:c.C2065T:p.R689C	9p13.3	C3L-01031	3.423e-05	0	0	0	0	6.267e-05	0	0	rs775041042	4.20	T	D	B	B	N	D	L	T	D	0.230	T	T	T	0.102	0.598	0.601	0.209	T	T	T	T	T	T	2.014	19.360	0.915	D	N	-0.605	0.979	-0.533	1.149	0.821	0.732	0.702	0.744	0.636	.	5.440	2.590	2.006	-0.127	-0.104	0.953	0.891	0.738	109	.	.	.	ID=COSV53055142;OCCURENCE=1(large_intestine)	PIGO	354	0	917	63	0.0642857142857143	TRUE	TRUE
ENSG00000196116.8	.	BCM	GRCh38.p13	chr9	97495824	97495824	+	G	G	A	Missense_Mutation	SNP	ENST00000355295.5	exon17	c.G3238A	p.D1080N	exonic	ENSG00000196116.8	.	nonsynonymous SNV	ENSG00000196116.8:ENST00000355295.5:exon17:c.G3238A:p.D1080N	9q22.33	C3L-01031	.	.	.	.	.	.	.	.	rs879227282	14.20	D	D	D	D	D	D	M	T	D	0.795	T	T	D	0.356	0.511	0.725	0.662	T	D	T	T	D	D	4.157	28.300	0.999	D	D	0.853	9.909	0.840	11.403	1.000	0.732	0.744	0.618	0.613	.	5.200	5.200	9.516	1.176	0.676	1.000	0.921	0.987	481	.	.	.	.	TDRD7	485	1	920	53	0.0544707091469681	TRUE	NA
ENSG00000136937.13	.	BCM	GRCh38.p13	chr9	97661011	97661011	+	G	G	A	Missense_Mutation	SNP	ENST00000375147.8	exon16	c.G1543A	p.D515N	exonic	ENSG00000136937.13	.	nonsynonymous SNV	ENSG00000136937.13:ENST00000375147.8:exon16:c.G1543A:p.D515N	9q22.33	C3L-01031	.	.	.	.	.	.	.	.	.	9.19	D	D	B	P	D	D	L	.	D	0.137	T	T	T	0.176	0.379	0.677	1.133	T	T	T	T	D	D	3.434	24.500	0.999	D	D	0.364	4.130	0.480	4.982	1.000	0.707	0.725	0.725	0.714	.	5.450	5.450	5.924	1.176	0.676	1.000	1.000	1.000	719	MIF4G-like,_type_2	.	.	.	NCBP1	135	0	266	21	0.0731707317073171	TRUE	TRUE
ENSG00000177354.12	.	BCM	GRCh38.p13	chr10	49326572	49326572	+	G	G	A	Missense_Mutation	SNP	ENST00000374144.8	exon3	c.G4027A	p.V1343M	exonic	ENSG00000177354.12	.	nonsynonymous SNV	ENSG00000177354.12:ENST00000374144.8:exon3:c.G4027A:p.V1343M	10q11.23	C3L-01031	.	.	.	.	.	.	.	.	rs906410500	6.15	D	D	.	.	U	D	.	T	N	0.148	T	T	D	0.085	0.172	0.337	0.347	.	.	T	T	D	T	2.762	22.900	0.999	D	N	0.185	3.237	0.220	3.282	1.000	0.487	0.590	0.547	0.564	.	5.360	5.360	3.615	1.176	0.610	1.000	0.193	0.236	894	.	.	.	ID=COSV60510676;OCCURENCE=1(stomach)	C10orf71	219	0	629	36	0.0541353383458647	TRUE	TRUE
ENSG00000170370.12	.	BCM	GRCh38.p13	chr10	117543443	117543443	+	C	C	G	Missense_Mutation	SNP	ENST00000553456.5	exon1	c.C176G	p.A59G	exonic	ENSG00000170370.12	.	nonsynonymous SNV	ENSG00000170370.12:ENST00000553456.5:exon1:c.C176G:p.A59G	10q26.11	C3L-01031	.	.	.	.	.	.	.	.	.	11.20	D	T	B	B	D	D	N	D	N	0.151	D	D	D	0.301	0.436	0.851	.	T	T	D	T	D	T	2.458	22.300	0.885	D	D	0.021	2.587	0.224	3.306	1.000	0.598	0.590	0.378	0.639	.	5.810	5.810	4.902	1.011	0.569	1.000	0.999	0.953	784	.	.	.	.	EMX2	273	0	835	62	0.0691192865105909	TRUE	TRUE
ENSG00000110427.16	.	BCM	GRCh38.p13	chr11	33542848	33542848	+	A	A	T	Missense_Mutation	SNP	ENST00000321505.9	exon1	c.A394T	p.I132L	exonic	ENSG00000110427.16	.	nonsynonymous SNV	ENSG00000110427.16:ENST00000321505.9:exon1:c.A394T:p.I132L	11p13	C3L-01031	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	.	N	N	.	N	0.080	T	T	T	0.009	0.213	0.061	0.170	T	T	T	T	T	T	0.665	8.134	0.769	N	N	-1.513	0.077	-1.504	0.106	1.000	0.744	0.588	0.659	0.584	.	4.830	-2.280	-0.484	-0.943	-0.875	0.000	0.846	0.211	683	.	.	.	.	KIAA1549L	109	0	236	98	0.293413173652695	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01031	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	315	0	581	280	0.32520325203252	TRUE	TRUE
ENSG00000118600.12	.	BCM	GRCh38.p13	chr12	63781145	63781145	+	G	G	A	Missense_Mutation	SNP	ENST00000261234.11	exon2	c.G296A	p.S99N	exonic	ENSG00000118600.12	.	nonsynonymous SNV	ENSG00000118600.12:ENST00000261234.11:exon2:c.G296A:p.S99N	12q14.2	C3L-01031	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	.	T	N	0.087	T	T	T	0.026	0.280	0.085	0.153	T	T	T	T	T	T	-0.450	0.151	0.753	N	N	-1.339	0.144	-1.406	0.149	1.000	0.543	0.686	0.731	0.639	.	4.340	-3.420	-0.452	-2.199	-0.182	0.000	0.025	0.825	921	.	.	.	.	RXYLT1	123	0	188	13	0.0646766169154229	TRUE	TRUE
ENSG00000136051.15	.	BCM	GRCh38.p13	chr12	105164713	105164713	+	G	G	C	Missense_Mutation	SNP	ENST00000332180.10	exon32	c.G3427C	p.E1143Q	exonic	ENSG00000136051.15	.	nonsynonymous SNV	ENSG00000136051.15:ENST00000332180.10:exon32:c.G3427C:p.E1143Q	12q23.3	C3L-01031	.	.	.	.	.	.	.	.	.	10.19	D	D	D	D	D	D	.	T	N	0.517	T	T	T	0.309	0.153	0.757	0.706	T	T	T	T	D	D	4.512	32	0.998	D	D	0.967	12.904	0.975	17.361	1.000	0.719	0.725	0.725	0.734	.	6.170	6.170	9.918	1.176	0.676	1.000	1.000	0.992	682	.	.	.	.	WASHC4	293	1	658	37	0.0532374100719424	TRUE	NA
ENSG00000089169.15	.	BCM	GRCh38.p13	chr12	112890045	112890045	+	G	G	A	Missense_Mutation	SNP	ENST00000389385.9	exon18	c.G1585A	p.G529R	exonic	ENSG00000089169.15	.	nonsynonymous SNV	ENSG00000089169.15:ENST00000389385.9:exon18:c.G1585A:p.G529R	12q24.13	C3L-01031	1.648e-05	0	8.637e-05	0	0	1.499e-05	0	0	rs756037748	12.20	D	D	P	B	D	D	L	T	D	0.840	T	T	D	0.379	0.518	0.692	0.357	T	T	D	D	D	D	2.954	23.300	0.994	D	D	0.192	3.267	0.172	3.048	1.000	0.598	0.578	0.578	0.639	.	5.290	5.290	6.146	1.176	0.676	1.000	0.627	0.152	88	.	.	.	ID=COSV66990225;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	RPH3A	161	0	447	126	0.219895287958115	TRUE	TRUE
ENSG00000187498.16	.	BCM	GRCh38.p13	chr13	110176428	110176428	+	C	C	A	Missense_Mutation	SNP	ENST00000375820.10	exon36	c.G3054T	p.L1018F	exonic	ENSG00000187498.16	.	nonsynonymous SNV	ENSG00000187498.16:ENST00000375820.10:exon36:c.G3054T:p.L1018F	13q34	C3L-01031	.	.	.	.	.	.	.	.	.	12.20	D	T	D	D	N	D	L	D	N	0.346	D	D	D	0.400	0.373	0.600	1.245	T	D	T	T	D	D	2.371	22.000	0.998	D	N	0.179	3.212	0.150	2.951	0.988	0.732	0.590	0.744	0.711	.	5.420	2.780	0.627	0.125	0.599	0.999	0.993	0.979	994	.	.	.	.	COL4A1	475	1	1255	376	0.230533415082771	TRUE	TRUE
ENSG00000151812.15	.	BCM	GRCh38.p13	chr14	57589457	57589457	+	C	C	T	Missense_Mutation	SNP	ENST00000339762.10	exon3	c.G454A	p.A152T	exonic	ENSG00000151812.15	.	nonsynonymous SNV	ENSG00000151812.15:ENST00000339762.10:exon3:c.G454A:p.A152T	14q22.3	C3L-01031	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.071	T	T	T	0.070	0.277	0.361	0.041	T	T	T	T	T	T	1.591	16.320	0.970	D	N	-0.493	1.190	-0.254	1.661	0.000	0.487	0.574	0.574	0.564	.	6.060	4.040	2.195	0.065	-0.187	1.000	0.995	0.975	863	.	.	.	ID=COSV100333696;OCCURENCE=3(central_nervous_system)	SLC35F4	160	0	298	30	0.0914634146341463	TRUE	TRUE
ENSG00000036530.9	.	BCM	GRCh38.p13	chr14	99707601	99707601	+	G	G	T	Missense_Mutation	SNP	ENST00000261835.8	exon7	c.G616T	p.G206C	exonic	ENSG00000036530.9	.	nonsynonymous SNV	ENSG00000036530.9:ENST00000261835.8:exon7:c.G616T:p.G206C	14q32.2	C3L-01031	.	.	.	.	.	.	.	.	.	11.20	D	D	P	P	N	D	M	D	D	0.357	T	T	D	0.269	0.592	0.715	1.725	T	D	T	T	D	T	4.008	27.000	0.997	D	D	0.221	3.395	0.293	3.678	0.882	0.554	0.574	0.602	0.542	.	4.480	4.480	3.563	1.176	0.676	1.000	1.000	1.000	941	.	.	.	.	CYP46A1	165	0	299	172	0.365180467091295	TRUE	TRUE
ENSG00000104044.16	.	BCM	GRCh38.p13	chr15	27871239	27871239	+	C	C	T	Missense_Mutation	SNP	ENST00000354638.8	exon21	c.G2159A	p.R720H	exonic	ENSG00000104044.16	.	nonsynonymous SNV	ENSG00000104044.16:ENST00000354638.8:exon21:c.G2159A:p.R720H	15q13.1	C3L-01031	8.308e-06	0	0	0	0	0	0	6.071e-05	rs776631782	18.20	D	D	D	D	D	D	L	D	D	0.874	D	D	D	0.806	0.851	0.988	0.534	T	D	D	D	D	D	4.060	27.400	0.999	D	D	0.650	6.472	0.598	6.203	1.000	0.554	0.574	0.602	0.564	.	5.420	5.420	7.194	1.026	0.599	1.000	0.448	0.168	976	Citrate_transporter-like_domain	.	.	ID=COSV62343363;OCCURENCE=1(pancreas)	OCA2	469	0	1153	106	0.0841938046068308	TRUE	TRUE
ENSG00000159433.12	.	BCM	GRCh38.p13	chr15	42688227	42688227	+	G	G	C	Missense_Mutation	SNP	ENST00000290607.12	exon23	c.G6649C	p.E2217Q	exonic	ENSG00000159433.12	.	nonsynonymous SNV	ENSG00000159433.12:ENST00000290607.12:exon23:c.G6649C:p.E2217Q	15q15.2	C3L-01031	.	.	.	.	.	.	.	.	.	1.16	T	.	.	.	.	N	L	T	N	0.087	T	T	D	0.054	0.164	0.151	.	T	T	T	T	T	T	0.780	9.199	0.989	N	N	-0.625	0.944	-0.755	0.821	0.996	0.557	0.546	0.659	0.297	.	5.300	0.646	0.055	0.222	0.676	0.002	0.001	0.038	91	.	.	.	ID=COSV51898800;OCCURENCE=3(oesophagus)	STARD9	219	0	432	33	0.0709677419354839	TRUE	TRUE
ENSG00000074803.20	.	BCM	GRCh38.p13	chr15	48244864	48244864	+	G	G	A	Missense_Mutation	SNP	ENST00000380993.8	exon11	c.G1412A	p.R471Q	exonic	ENSG00000074803.20	.	nonsynonymous SNV	ENSG00000074803.20:ENST00000380993.8:exon11:c.G1412A:p.R471Q	15q21.1	C3L-01031	.	.	.	.	.	.	.	.	rs369307402	2.20	T	T	B	B	N	N	N	D	N	0.200	T	T	D	0.255	.	0.524	0.163	T	T	T	T	T	T	0.568	7.200	0.636	N	N	-1.611	0.053	-1.628	0.068	1.000	0.487	0.590	0.547	0.564	.	5.580	-7.250	0.036	-0.482	-0.642	0.000	0.961	0.843	727	Amino_acid_permease/_SLC12A_domain	.	.	ID=COSV101119520;OCCURENCE=1(large_intestine)	SLC12A1	251	0	553	52	0.0859504132231405	TRUE	NA
ENSG00000138600.10	.	BCM	GRCh38.p13	chr15	50726350	50726350	+	C	C	T	Missense_Mutation	SNP	ENST00000261854.10	exon11	c.G1117A	p.A373T	exonic	ENSG00000138600.10	.	nonsynonymous SNV	ENSG00000138600.10:ENST00000261854.10:exon11:c.G1117A:p.A373T	15q21.2	C3L-01031	2.489e-05	0	0	0	0	1.511e-05	0	0.0001	rs550930877	15.20	D	D	D	D	D	D	H	T	D	0.921	T	T	D	0.472	0.849	0.641	0.592	T	T	D	D	D	D	4.001	27.000	0.999	D	D	0.847	9.774	0.830	11.080	1.000	0.732	0.725	0.710	0.728	.	5.830	5.830	6.396	1.026	0.549	1.000	1.000	0.992	344	.	.	.	ID=COSV55942276;OCCURENCE=1(oesophagus)	SPPL2A	228	0	385	25	0.0609756097560976	TRUE	TRUE
ENSG00000140955.11	.	BCM	GRCh38.p13	chr16	84196670	84196670	+	G	G	C	Missense_Mutation	SNP	ENST00000315906.10	exon9	c.G1550C	p.R517P	exonic	ENSG00000140955.11	.	nonsynonymous SNV	ENSG00000140955.11:ENST00000315906.10:exon9:c.G1550C:p.R517P	16q24.1	C3L-01031	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	D	D	0.874	D	D	D	0.911	0.841	0.956	.	T	D	D	D	D	T	4.346	29.900	0.996	D	D	0.667	6.677	0.568	5.841	1.000	0.581	0.627	0.576	0.563	.	5.270	4.250	1.369	1.176	0.618	1.000	0.828	0.910	759	Adenosine_deaminase/editase	.	.	.	ADAD2	117	0	321	118	0.26879271070615	TRUE	TRUE
ENSG00000181291.8	.	BCM	GRCh38.p13	chr17	34637708	34637708	+	G	G	A	Missense_Mutation	SNP	ENST00000631683.2	exon9	c.G2701A	p.A901T	exonic	ENSG00000181291.8	.	nonsynonymous SNV	ENSG00000181291.8:ENST00000631683.2:exon9:c.G2701A:p.A901T	17q12	C3L-01031	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.832	T	T	D	0.600	0.559	0.313	1.345	D	T	D	D	D	D	4.476	32	0.999	D	D	0.869	10.272	0.798	10.067	1.000	0.765	0.563	0.732	0.530	.	4.500	4.500	9.993	1.175	0.606	1.000	0.997	0.987	970	Transmembrane_protein_TMEM132,_C-terminal	.	.	ID=COSV58698849;OCCURENCE=1(prostate)	TMEM132E	176	2	593	56	0.086286594761171	TRUE	TRUE
ENSG00000141449.14	.	BCM	GRCh38.p13	chr18	21401201	21401201	+	C	C	T	Missense_Mutation	SNP	ENST00000580732.6	exon6	c.C584T	p.T195M	exonic	ENSG00000141449.14	.	nonsynonymous SNV	ENSG00000141449.14:ENST00000580732.6:exon6:c.C584T:p.T195M	18q11.1	C3L-01031	.	.	.	.	.	.	.	.	.	13.19	D	D	D	D	.	D	L	T	D	0.876	T	T	T	0.617	0.566	0.451	.	D	T	D	D	D	D	3.794	25.800	0.997	D	D	0.898	11.001	0.883	13.038	1.000	0.625	0.574	0.590	0.595	.	5.800	5.800	7.905	1.026	0.599	1.000	1.000	0.994	424	.	.	.	.	GREB1L	246	0	724	112	0.133971291866029	TRUE	NA
ENSG00000130377.13	.	BCM	GRCh38.p13	chr19	6141545	6141545	+	T	T	C	Translation_Start_Site	SNP	ENST00000586696.5	exon2	c.T2C	p.M1?	exonic	ENSG00000130377.13	.	startloss	ENSG00000130377.13:ENST00000586696.5:exon2:c.T2C:p.M1?	19p13.3	C3L-01031	.	.	.	.	.	.	.	.	.	2.15	.	D	B	B	.	N	.	T	.	0.277	T	T	T	0.084	0.982	0.095	.	.	T	T	T	T	D	0.115	2.227	0.576	N	N	-1.163	0.255	-1.254	0.241	0.000	0.487	0.574	0.574	0.542	.	4.240	-1.880	-0.665	-0.601	-0.203	0.000	0.003	0.005	917	.	.	.	.	ACSBG2	195	0	323	83	0.204433497536946	TRUE	TRUE
ENSG00000167772.12	.	BCM	GRCh38.p13	chr19	8366293	8366293	+	C	C	T	Missense_Mutation	SNP	ENST00000301455.7	exon3	c.C521T	p.P174L	exonic	ENSG00000167772.12	.	nonsynonymous SNV	ENSG00000167772.12:ENST00000301455.7:exon3:c.C521T:p.P174L	19p13.2	C3L-01031	0.0003	0	0.0003	0.0001	0	4.524e-05	0.0011	0.0014	rs533599788	0.20	T	T	B	B	N	N	L	T	N	0.217	T	T	T	0.021	.	0.499	0.198	T	T	T	T	T	T	-0.528	0.104	0.439	N	N	-1.316	0.156	-1.321	0.195	1.000	0.677	0.590	0.673	0.655	.	4.190	0.861	-0.450	-3.802	-1.690	0.000	0.000	0.001	856	.	.	.	ID=COSV56845072;OCCURENCE=1(large_intestine)	ANGPTL4	412	0	1017	240	0.190930787589499	TRUE	TRUE
ENSG00000181143.15	.	BCM	GRCh38.p13	chr19	8948250	8948250	+	G	G	A	Missense_Mutation	SNP	ENST00000397910.8	exon3	c.C28520T	p.T9507M	exonic	ENSG00000181143.15	.	nonsynonymous SNV	ENSG00000181143.15:ENST00000397910.8:exon3:c.C28520T:p.T9507M	19p13.2	C3L-01031	3.314e-05	0.0001	0	0	0	4.498e-05	0	0	rs370765065	3.15	D	D	.	.	.	N	.	T	D	0.042	T	T	T	0.040	.	0.153	.	T	.	T	T	T	T	-0.083	0.898	0.253	N	N	-1.428	0.106	-1.493	0.110	0.001	0.487	0.574	0.574	0.564	.	2.290	-1.470	-0.072	-1.428	-1.579	0.000	0.000	0.001	917	.	.	.	ID=COSV67449619;OCCURENCE=1(large_intestine),1(haematopoietic_and_lymphoid_tissue),1(endometrium)	MUC16	173	0	322	24	0.069364161849711	TRUE	TRUE
ENSG00000104998.4	.	BCM	GRCh38.p13	chr19	14046195	14046195	+	C	C	G	Missense_Mutation	SNP	ENST00000263379.4	exon7	c.C810G	p.F270L	exonic	ENSG00000104998.4	.	nonsynonymous SNV	ENSG00000104998.4:ENST00000263379.4:exon7:c.C810G:p.F270L	19p13.12	C3L-01031	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.506	T	T	D	0.058	0.489	0.285	0.209	T	T	T	T	T	T	0.983	11.410	0.748	N	N	-1.050	0.353	-1.072	0.405	0.003	0.617	0.698	0.786	0.655	.	4.520	0.435	1.381	-0.772	-0.186	0.007	0.001	0.012	824	.	.	.	.	IL27RA	182	0	400	23	0.0543735224586288	TRUE	TRUE
ENSG00000039650.12	.	BCM	GRCh38.p13	chr19	49861678	49861678	+	C	C	G	Missense_Mutation	SNP	ENST00000322344.8	exon15	c.G1316C	p.R439P	exonic	ENSG00000039650.12	.	nonsynonymous SNV	ENSG00000039650.12:ENST00000322344.8:exon15:c.G1316C:p.R439P	19q13.33	C3L-01031	.	.	.	.	.	.	.	.	.	5.20	D	D	P	B	N	N	L	T	N	0.528	T	T	D	0.222	0.530	0.670	0.473	T	T	T	T	D	D	1.363	14.830	0.981	N	N	-0.535	1.108	-0.759	0.815	1.000	0.672	0.702	0.644	0.636	.	4.090	-0.918	-0.387	-0.667	0.593	0.000	0.000	0.001	594	.	.	.	.	PNKP	178	0	654	38	0.0549132947976879	TRUE	TRUE
ENSG00000167755.15	.	BCM	GRCh38.p13	chr19	50967223	50967223	+	C	C	A	Missense_Mutation	SNP	ENST00000310157.7	exon4	c.G143T	p.G48V	exonic	ENSG00000167755.15	.	nonsynonymous SNV	ENSG00000167755.15:ENST00000310157.7:exon4:c.G143T:p.G48V	19q13.41	C3L-01031	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	H	D	D	0.664	D	D	D	0.821	0.934	0.985	0.916	T	D	D	D	D	D	3.008	23.400	0.997	D	D	0.632	6.266	0.438	4.642	0.967	0.615	0.563	0.659	0.605	.	4.310	4.310	3.611	1.022	0.596	0.751	0.028	0.125	912	Serine_proteases,_trypsin_domain	.	.	ID=COSV59565217;OCCURENCE=1(lung)	KLK6	233	0	714	55	0.0715214564369311	TRUE	TRUE
ENSG00000142156.15	.	BCM	GRCh38.p13	chr21	46001357	46001357	+	G	G	A	Missense_Mutation	SNP	ENST00000361866.8	exon30	c.G1927A	p.D643N	exonic	ENSG00000142156.15	.	nonsynonymous SNV	ENSG00000142156.15:ENST00000361866.8:exon30:c.G1927A:p.D643N	21q22.3	C3L-01031	.	.	.	.	.	.	.	.	rs369365801	6.20	T	T	D	P	D	D	L	T	N	0.453	T	T	D	0.441	0.707	0.834	0.823	T	T	T	T	D	T	3.242	24.000	0.986	N	D	0.241	3.492	0.243	3.401	1.000	0.718	0.588	0.571	0.563	.	5.200	5.200	4.723	1.094	0.660	1.000	0.825	0.466	976	von_Willebrand_factor,_type_A	.	.	ID=COSV62613550;OCCURENCE=1(pancreas)	COL6A1	235	0	636	49	0.0715328467153285	TRUE	TRUE
ENSG00000138944.8	.	BCM	GRCh38.p13	chr22	44285547	44285547	+	C	C	A	Missense_Mutation	SNP	ENST00000381176.5	exon4	c.G480T	p.Q160H	exonic	ENSG00000138944.8	.	nonsynonymous SNV	ENSG00000138944.8:ENST00000381176.5:exon4:c.G480T:p.Q160H	22q13.31	C3L-01031	.	.	.	.	.	.	.	.	.	2.17	T	T	P	P	N	.	.	.	N	0.303	T	T	T	0.067	0.175	0.281	0.519	T	T	T	T	D	T	2.949	23.300	0.994	D	N	-0.026	2.419	-0.016	2.304	1.000	0.581	0.590	0.576	0.563	.	4.240	4.240	3.736	0.933	0.505	1.000	0.187	0.039	883	.	.	.	.	SHISAL1	114	1	174	10	0.0543478260869565	NA	TRUE
ENSG00000101871.15	.	BCM	GRCh38.p13	chrX	10567013	10567013	+	C	C	T	Missense_Mutation	SNP	ENST00000317552.9	exon2	c.G535A	p.E179K	exonic	ENSG00000101871.15	.	nonsynonymous SNV	ENSG00000101871.15:ENST00000317552.9:exon2:c.G535A:p.E179K	Xp22.2	C3L-01031	.	.	.	.	.	.	.	.	.	7.19	T	T	P	P	D	D	L	T	N	0.691	T	T	D	0.112	0.506	0.561	1.483	D	T	T	T	D	D	2.426	22.200	0.997	D	.	.	.	.	.	1.000	.	.	.	.	.	5.640	5.640	6.023	1.026	0.599	1.000	1.000	0.982	603	B-box-type_zinc_finger	.	.	.	MID1	527	0	1257	76	0.0570142535633908	TRUE	TRUE
ENSG00000169297.8	.	BCM	GRCh38.p13	chrX	30308645	30308645	+	G	G	A	Missense_Mutation	SNP	ENST00000378970.5	exon1	c.C719T	p.S240F	exonic	ENSG00000169297.8	.	nonsynonymous SNV	ENSG00000169297.8:ENST00000378970.5:exon1:c.C719T:p.S240F	Xp21.2	C3L-01031	.	.	.	.	.	.	.	.	.	5.19	T	D	P	B	N	N	L	D	N	0.155	D	D	D	0.401	0.447	0.632	0.830	T	T	T	T	T	T	0.527	6.781	0.992	N	.	.	.	.	.	1.000	.	.	.	.	.	3.980	2.070	-0.011	-0.973	-0.954	0.024	0.000	0.001	832	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	NR0B1	198	0	667	43	0.0605633802816901	TRUE	NA
ENSG00000147118.12	.	BCM	GRCh38.p13	chrX	47977579	47977579	+	T	T	C	Missense_Mutation	SNP	ENST00000396965.5	exon7	c.A508G	p.N170D	exonic	ENSG00000147118.12	.	nonsynonymous SNV	ENSG00000147118.12:ENST00000396965.5:exon7:c.A508G:p.N170D	Xp11.23	C3L-01031	.	.	.	.	.	.	.	.	.	1.18	T	T	B	B	.	N	M	T	N	0.266	T	T	T	0.058	0.254	0.435	0.522	T	T	T	T	T	T	1.455	15.440	0.989	N	.	.	.	.	.	0.009	.	.	.	.	.	3.730	3.730	2.531	1.138	0.665	0.898	0.995	0.994	595	.	.	.	.	ZNF182	135	0	206	11	0.0506912442396313	TRUE	TRUE
ENSG00000147255.19	.	BCM	GRCh38.p13	chrX	131277943	131277943	+	C	C	T	Missense_Mutation	SNP	ENST00000361420.8	exon13	c.G2233A	p.E745K	exonic	ENSG00000147255.19	.	nonsynonymous SNV	ENSG00000147255.19:ENST00000361420.8:exon13:c.G2233A:p.E745K	Xq26.1	C3L-01031	2.279e-05	0	0	0	0	2.084e-05	0	9.881e-05	rs778830663	3.19	D	T	P	B	N	N	L	T	N	0.187	T	T	D	0.056	0.424	0.151	0.395	T	T	T	T	T	D	1.247	14.000	0.972	N	.	.	.	.	.	0.999	.	.	.	.	.	4.880	-0.898	-0.743	1.026	0.599	0.000	0.995	0.998	61	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV100812485;OCCURENCE=1(cervix)	IGSF1	262	0	618	62	0.0911764705882353	TRUE	NA
ENSG00000212747.5	.	BCM	GRCh38.p13	chrX	135022248	135022248	+	C	C	T	Missense_Mutation	SNP	ENST00000391440.3	exon1	c.G212A	p.R71H	exonic	ENSG00000212747.5	.	nonsynonymous SNV	ENSG00000212747.5:ENST00000391440.3:exon1:c.G212A:p.R71H	Xq26.3	C3L-01031	.	.	.	.	.	.	.	.	.	6.18	D	T	D	D	U	N	.	T	N	0.274	T	T	D	0.204	0.555	0.682	1.374	T	T	T	T	D	D	3.762	25.700	0.999	N	.	.	.	.	.	1.000	.	.	.	.	.	2.350	2.350	1.841	0.845	0.530	1.000	1.000	0.999	484	Domain_of_unknown_function_DUF4939	.	.	ID=COSV66954595;OCCURENCE=1(large_intestine)	RTL8B	179	0	549	35	0.0599315068493151	NA	TRUE
ENSG00000067842.17	.	BCM	GRCh38.p13	chrX	153541512	153541512	+	C	C	G	Missense_Mutation	SNP	ENST00000263519.4	exon2	c.C362G	p.S121C	exonic	ENSG00000067842.17	.	nonsynonymous SNV	ENSG00000067842.17:ENST00000263519.4:exon2:c.C362G:p.S121C	Xq28	C3L-01031	.	.	.	.	.	.	.	.	.	19.19	D	D	D	D	D	D	H	D	D	0.814	D	D	D	0.896	0.716	0.960	1.526	D	D	D	D	D	D	3.446	24.500	0.991	D	.	.	.	.	.	1.000	.	.	.	.	.	5.690	5.690	7.902	1.022	0.596	1.000	0.989	0.905	109	Cation-transporting_P-type_ATPase,_N-terminal	.	.	.	ATP2B3	298	0	972	57	0.0553935860058309	TRUE	TRUE
ENSG00000162402.14	.	BCM	GRCh38.p13	chr1	55157255	55157255	+	C	C	G	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000162402.14	ENST00000294383.7:exon11:c.1342+1G>C	.	.	1p32.3	C3L-01031	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.483	34	0.995	D	.	1.126	18.735	0.982	17.802	1.000	0.322	0.319	0.121	0.110	0.982	5.930	5.930	7.568	1.026	0.549	1.000	1.000	0.990	878	.	.	.	.	USP24	224	0	335	77	0.186893203883495	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675237	7675237	+	C	C	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000141510.17	ENST00000269305.8:exon5:c.376-1G>A	.	.	17p13.1	C3L-01031	.	.	.	.	.	.	.	.	rs868137297	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.764	34	0.992	D	.	1.034	15.036	0.849	11.733	1.000	0.284	0.272	0.299	0.344	0.828	4.870	3.900	7.742	1.026	0.599	1.000	0.929	0.884	434	.	.	.	ID=COSV52688618;OCCURENCE=14(breast),7(liver),6(oesophagus),10(large_intestine),5(central_nervous_system),1(biliary_tract),1(fallopian_tube),5(ovary),1(NS),6(haematopoietic_and_lymphoid_tissue),4(stomach),2(soft_tissue),1(urinary_tract),8(pancreas),1(skin),2(prostate),2(lung),4(upper_aerodigestive_tract)	TP53	301	0	418	197	0.320325203252033	TRUE	TRUE
ENSG00000157881.16	.	BCM	GRCh38.p13	chr1	2518194	2518194	+	G	G	A	Silent	SNP	ENST00000378466.9	exon9	c.C1188T	p.L396L	exonic	ENSG00000157881.16	.	synonymous SNV	ENSG00000157881.16:ENST00000378466.9:exon9:c.C1188T:p.L396L	1p36.32	C3L-01031	0.0014	0	0.0003	0	0	1.564e-05	0.0023	0.0097	rs201136616	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PANK4	140	1	420	32	0.0707964601769911	TRUE	NA
ENSG00000204262.14	.	BCM	GRCh38.p13	chr2	189039285	189039285	+	G	G	A	Silent	SNP	ENST00000374866.9	exon51	c.C3912T	p.S1304S	exonic	ENSG00000204262.14	.	synonymous SNV	ENSG00000204262.14:ENST00000374866.9:exon51:c.C3912T:p.S1304S	2q32.2	C3L-01031	1.648e-05	0	0	0	0	2.998e-05	0	0	rs571598585	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL5A2	452	1	949	165	0.148114901256732	TRUE	NA
ENSG00000112992.18	.	BCM	GRCh38.p13	chr5	43649151	43649151	+	C	C	G	Silent	SNP	ENST00000344920.9	exon11	c.C1449G	p.L483L	exonic	ENSG00000112992.18	.	synonymous SNV	ENSG00000112992.18:ENST00000344920.9:exon11:c.C1449G:p.L483L	5p12	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NNT	128	0	323	18	0.0527859237536657	TRUE	TRUE
ENSG00000158458.21	.	BCM	GRCh38.p13	chr5	139848067	139848067	+	C	C	T	Silent	SNP	ENST00000361474.6	exon10	c.G2403A	p.A801A	exonic	ENSG00000158458.21	.	synonymous SNV	ENSG00000158458.21:ENST00000361474.6:exon10:c.G2403A:p.A801A	5q31.2	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NRG2	317	0	959	411	0.3	TRUE	TRUE
ENSG00000096088.16	.	BCM	GRCh38.p13	chr6	41742322	41742322	+	G	G	A	Silent	SNP	ENST00000373025.7	exon5	c.C615T	p.L205L	exonic	ENSG00000096088.16	.	synonymous SNV	ENSG00000096088.16:ENST00000373025.7:exon5:c.C615T:p.L205L	6p21.1	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PGC	213	0	736	40	0.0515463917525773	TRUE	TRUE
ENSG00000096088.16	.	BCM	GRCh38.p13	chr6	41742400	41742400	+	G	G	A	Silent	SNP	ENST00000373025.7	exon5	c.C537T	p.I179I	exonic	ENSG00000096088.16	.	synonymous SNV	ENSG00000096088.16:ENST00000373025.7:exon5:c.C537T:p.I179I	6p21.1	C3L-01031	.	.	.	.	.	.	.	.	rs879101322	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PGC	394	0	1125	70	0.0585774058577406	TRUE	NA
ENSG00000167632.17	.	BCM	GRCh38.p13	chr8	140275803	140275803	+	T	T	C	Silent	SNP	ENST00000438773.4	exon15	c.A2133G	p.Q711Q	exonic	ENSG00000167632.17	.	synonymous SNV	ENSG00000167632.17:ENST00000438773.4:exon15:c.A2133G:p.Q711Q	8q24.3	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRAPPC9	322	0	612	44	0.0670731707317073	TRUE	NA
ENSG00000187783.12	.	BCM	GRCh38.p13	chr10	44935008	44935008	+	C	C	T	Silent	SNP	ENST00000544540.5	exon4	c.C348T	p.S116S	exonic	ENSG00000187783.12	.	synonymous SNV	ENSG00000187783.12:ENST00000544540.5:exon4:c.C348T:p.S116S	10q11.21	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101273622;OCCURENCE=1(skin)	TMEM72	188	0	398	87	0.179381443298969	TRUE	TRUE
ENSG00000132535.21	.	BCM	GRCh38.p13	chr17	7192990	7192990	+	G	G	A	Silent	SNP	ENST00000399506.9	exon17	c.C1821T	p.H607H	exonic	ENSG00000132535.21	.	synonymous SNV	ENSG00000132535.21:ENST00000399506.9:exon17:c.C1821T:p.H607H	17p13.1	C3L-01031	.	.	.	.	.	.	.	.	rs1006147091	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DLG4	202	0	470	31	0.06187624750499	TRUE	NA
ENSG00000180336.18	.	BCM	GRCh38.p13	chr17	44667114	44667114	+	G	G	A	Silent	SNP	ENST00000409122.7	exon5	c.G1203A	p.L401L	exonic	ENSG00000180336.18	.	synonymous SNV	ENSG00000180336.18:ENST00000409122.7:exon5:c.G1203A:p.L401L	17q21.31	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MEIOC	199	1	332	24	0.0674157303370786	TRUE	TRUE
ENSG00000141384.13	.	BCM	GRCh38.p13	chr18	26227209	26227209	+	G	G	A	Silent	SNP	ENST00000269142.10	exon1	c.G276A	p.Q92Q	exonic	ENSG00000141384.13	.	synonymous SNV	ENSG00000141384.13:ENST00000269142.10:exon1:c.G276A:p.Q92Q	18q11.2	C3L-01031	8.29e-06	0	0	0	0	1.501e-05	0	0	rs780195768	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TAF4B	443	0	983	78	0.0735155513666352	TRUE	NA
ENSG00000130702.15	.	BCM	GRCh38.p13	chr20	62333666	62333666	+	C	C	T	Silent	SNP	ENST00000252999.7	exon24	c.G2919A	p.T973T	exonic	ENSG00000130702.15	.	synonymous SNV	ENSG00000130702.15:ENST00000252999.7:exon24:c.G2919A:p.T973T	20q13.33	C3L-01031	0.0006	0.0044	0	0	0	0.0001	0	0.0003	rs147701856	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LAMA5	93	0	362	173	0.323364485981308	TRUE	NA
ENSG00000101210.12	.	BCM	GRCh38.p13	chr20	63495871	63495871	+	G	G	T	Silent	SNP	ENST00000217182.6	exon3	c.C309A	p.I103I	exonic	ENSG00000101210.12	.	synonymous SNV	ENSG00000101210.12:ENST00000217182.6:exon3:c.C309A:p.I103I	20q13.33	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EEF1A2	132	0	409	129	0.239776951672862	TRUE	TRUE
ENSG00000196132.14	.	BCM	GRCh38.p13	chr20	64232356	64232356	+	C	C	T	Silent	SNP	ENST00000328439.6	exon19	c.C2868T	p.H956H	exonic	ENSG00000196132.14	.	synonymous SNV	ENSG00000196132.14:ENST00000328439.6:exon19:c.C2868T:p.H956H	20q13.33	C3L-01031	0.0002	0.0009	0	0	0	0.0001	0	0	rs144371248	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYT1	224	0	852	294	0.256544502617801	TRUE	NA
ENSG00000101871.15	.	BCM	GRCh38.p13	chrX	10567227	10567227	+	G	G	A	Silent	SNP	ENST00000317552.9	exon2	c.C321T	p.D107D	exonic	ENSG00000101871.15	.	synonymous SNV	ENSG00000101871.15:ENST00000317552.9:exon2:c.C321T:p.D107D	Xp22.2	C3L-01031	1.15e-05	0	0	0	0	2.091e-05	0	0	rs754833237	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100452340;OCCURENCE=1(stomach)	MID1	139	0	298	68	0.185792349726776	TRUE	NA
ENSG00000175556.17	.	BCM	GRCh38.p13	chrX	118974819	118974819	+	C	C	A	Silent	SNP	ENST00000371628.8	exon1	c.C39A	p.P13P	exonic	ENSG00000175556.17	.	synonymous SNV	ENSG00000175556.17:ENST00000371628.8:exon1:c.C39A:p.P13P	Xq24	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LONRF3	142	0	642	39	0.0572687224669604	TRUE	NA
ENSG00000155966.14	.	BCM	GRCh38.p13	chrX	148662459	148662459	+	C	C	T	Silent	SNP	ENST00000370460.7	exon3	c.C732T	p.F244F	exonic	ENSG00000155966.14	.	synonymous SNV	ENSG00000155966.14:ENST00000370460.7:exon3:c.C732T:p.F244F	Xq28	C3L-01031	6.839e-05	0.0001	0	0.0002	0	0	0	0.0004	rs370542676	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60671578;OCCURENCE=1(breast),1(oesophagus),1(large_intestine),1(endometrium)	AFF2	279	0	619	38	0.0578386605783866	TRUE	TRUE
ENSG00000232818.2	.	BCM	GRCh38.p13	chr7	23490630	23490630	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000232818.2	.	.	.	7p15.3	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RPS2P32	196	0	664	40	0.0568181818181818	TRUE	NA
ENSG00000255109.6	.	BCM	GRCh38.p13	chr11	42241099	42241099	+	C	C	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000255109.6	.	.	.	11p12	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC02740	294	0	536	86	0.138263665594855	TRUE	NA
ENSG00000156030.13	.	BCM	GRCh38.p13	chr14	73718964	73718964	+	T	T	C	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000156030.13	ENST00000286523.9:c.*337A>G	.	.	14q24.3	C3L-01031	.	.	.	.	.	.	.	.	.	3.3	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	D	2.132	20.400	0.916	D	.	.	.	.	.	1.000	0.257	0.272	0.064	0.221	0.976	5.620	5.620	7.586	1.138	0.663	1.000	0.994	0.990	443	Zinc_finger_C2H2-type	.	.	.	MIDEAS	61	0	153	67	0.304545454545455	TRUE	TRUE
ENSG00000179094.16	.	BCM	GRCh38.p13	chr17	8144661	8144661	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000179094.16	.	.	.	17p13.1	C3L-01031	.	.	.	.	.	.	.	.	.	4.14	D	T	.	.	.	D	.	T	N	0.070	T	T	D	0.077	0.183	0.103	.	.	.	T	T	D	T	0.694	8.404	0.980	N	N	-0.561	1.060	-0.582	1.073	0.999	0.421	0.553	0.537	0.509	.	3.700	3.700	0.575	0.154	0.676	0.002	0.069	0.107	303	.	.	.	.	PER1	80	0	231	19	0.076	TRUE	TRUE
ENSG00000131042.14	.	BCM	GRCh38.p13	chr19	54276646	54276646	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000131042.14	.	.	.	19q13.42	C3L-01031	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LILRB2	25	0	45	21	0.318181818181818	TRUE	NA
ENSG00000134253.10	.	BCM	GRCh38.p13	chr1	117121008	117121008	+	C	C	T	Missense_Mutation	SNP	ENST00000256649.9	exon1	c.G194A	p.R65Q	exonic	ENSG00000134253.10	.	nonsynonymous SNV	ENSG00000134253.10:ENST00000256649.9:exon1:c.G194A:p.R65Q	1p13.1	C3N-01167	.	.	.	.	.	.	.	.	.	6.19	T	D	P	B	N	D	M	D	N	0.077	T	T	D	0.183	0.449	0.858	0.278	T	T	T	T	D	T	2.567	22.600	0.998	N	.	-0.356	1.481	-0.309	1.545	1.000	0.628	0.406	0.672	0.375	.	4.910	3.990	1.936	1.022	0.596	0.433	0.925	0.589	778	Zinc_finger,_RING-type	.	.	ID=COSV56714109;OCCURENCE=1(urinary_tract),1(lung)	TRIM45	259	0	805	74	0.0841865756541524	TRUE	TRUE
ENSG00000163060.8	.	BCM	GRCh38.p13	chr2	94871584	94871584	+	C	C	A	Missense_Mutation	SNP	ENST00000295201.5	exon1	c.C5A	p.A2E	exonic	ENSG00000163060.8	.	nonsynonymous SNV	ENSG00000163060.8:ENST00000295201.5:exon1:c.C5A:p.A2E	2q11.1	C3N-01167	.	.	.	.	.	.	.	.	.	3.20	T	D	D	D	U	N	N	T	N	0.195	T	T	T	0.102	0.352	0.122	0.046	T	T	T	T	T	T	1.451	15.420	0.959	N	N	-0.506	1.164	-0.738	0.845	0.922	0.403	0.547	0.578	0.563	.	0.566	0.566	0.708	0.381	0.310	0.003	0.029	0.039	.	.	.	.	.	TEKT4	52	0	179	48	0.211453744493392	TRUE	TRUE
ENSG00000169994.18	.	BCM	GRCh38.p13	chr2	127576680	127576680	+	C	C	T	Missense_Mutation	SNP	ENST00000428314.5	exon8	c.C821T	p.T274M	exonic	ENSG00000169994.18	.	nonsynonymous SNV	ENSG00000169994.18:ENST00000428314.5:exon8:c.C821T:p.T274M	2q14.3	C3N-01167	2.522e-05	0.0001	0	0.0001	0	1.519e-05	0	0	rs755921738	2.20	T	T	B	B	N	N	L	D	N	0.187	T	T	D	0.070	0.420	0.250	0.088	T	T	T	T	T	T	0.923	10.690	0.907	N	N	-0.915	0.502	-0.932	0.577	1.000	0.653	0.659	0.056	0.542	.	4.940	0.523	-0.049	-2.006	-0.313	0.000	0.354	0.983	958	Myosin_head,_motor_domain;Class_VII_myosin,_motor_domain	.	.	ID=COSV67344428;OCCURENCE=1(breast)	MYO7B	77	0	170	25	0.128205128205128	TRUE	TRUE
ENSG00000115839.18	.	BCM	GRCh38.p13	chr2	135163083	135163083	+	A	A	-	Frame_Shift_Del	DEL	ENST00000264158.13	exon22	c.2588delA	p.K864Rfs*8	exonic	ENSG00000115839.18	.	frameshift deletion	ENSG00000115839.18:ENST00000264158.13:exon22:c.2588delA:p.K864Rfs*8	2q21.3	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAB3GAP1	350	1	891	139	0.13495145631068	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178592092	178592092	+	C	C	T	Missense_Mutation	SNP	ENST00000591111.5	exon252	c.G54889A	p.A18297T	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon252:c.G54889A:p.A18297T	2q31.2	C3N-01167	8.387e-06	0	0	0	0	1.513e-05	0	0	rs755204306	10.17	D	.	D	D	.	D	M	T	D	0.687	T	T	D	0.268	0.387	0.466	0.409	T	.	T	T	T	D	3.076	23.600	0.946	D	D	0.708	7.236	0.728	8.317	1.000	0.487	0.447	0.447	0.564	.	6.030	6.030	4.138	1.026	0.599	1.000	0.999	0.997	410	Fibronectin_type_III	.	.	ID=COSV60146923;OCCURENCE=1(skin)	TTN	259	0	508	152	0.23030303030303	TRUE	TRUE
ENSG00000168036.18	.	BCM	GRCh38.p13	chr3	41224622	41224622	+	C	C	G	Missense_Mutation	SNP	ENST00000349496.11	exon3	c.C110G	p.S37C	exonic	ENSG00000168036.18	.	nonsynonymous SNV	ENSG00000168036.18:ENST00000349496.11:exon3:c.C110G:p.S37C	3p22.1	C3N-01167	.	.	.	.	.	.	.	.	rs121913403	17.20	D	D	D	D	D	D	M	T	D	0.787	T	T	D	0.489	0.428	0.708	2.265	D	D	D	D	D	D	3.958	26.700	0.991	D	D	0.917	11.504	0.895	13.540	1.000	0.707	0.725	0.702	0.711	.	5.760	5.760	7.905	1.026	0.597	1.000	1.000	0.999	681	.	.	.	ID=COSV62688281;OCCURENCE=3(breast),47(liver),1(oesophagus),3(adrenal_gland),1(cervix),2(large_intestine),8(central_nervous_system),10(biliary_tract),1(paratesticular_tissues),28(ovary),1(bone),8(stomach),1(kidney),7(urinary_tract),1(soft_tissue),8(pancreas),13(pituitary),4(skin),4(prostate),19(lung),2(testis),42(endometrium)	CTNNB1	355	1	905	5	0.00549450549450549	TRUE	NA
ENSG00000152953.13	.	BCM	GRCh38.p13	chr4	5446768	5446768	+	C	C	T	Missense_Mutation	SNP	ENST00000282908.10	exon7	c.C658T	p.R220W	exonic	ENSG00000152953.13	.	nonsynonymous SNV	ENSG00000152953.13:ENST00000282908.10:exon7:c.C658T:p.R220W	4p16.2	C3N-01167	5.784e-05	0.0002	0	0	0	7.513e-05	0	0	rs745729733	10.20	D	T	D	D	U	D	L	T	D	0.838	T	T	T	0.220	0.645	0.613	0.142	D	T	T	T	D	D	4.331	29.800	0.999	D	D	0.508	5.100	0.518	5.329	0.975	0.638	0.574	0.659	0.668	.	5.390	5.390	1.579	1.026	0.599	1.000	0.986	0.994	964	Protein_kinase_domain	.	.	ID=COSV51481411;OCCURENCE=1(large_intestine),2(central_nervous_system),2(prostate),1(endometrium)	STK32B	192	0	414	119	0.223264540337711	TRUE	TRUE
ENSG00000174123.11	.	BCM	GRCh38.p13	chr4	38774888	38774888	+	G	G	A	Nonsense_Mutation	SNP	ENST00000308973.9	exon4	c.C703T	p.R235X	exonic	ENSG00000174123.11	.	stopgain	ENSG00000174123.11:ENST00000308973.9:exon4:c.C703T:p.R235X	4p14	C3N-01167	0.0001	9.66e-05	8.696e-05	0	0	3.012e-05	0.0022	0.0006	rs139408237	1.6	.	.	.	.	N	D	.	.	.	0.809	.	.	.	.	.	.	.	.	.	T	T	.	.	5.183	33	0.980	N	N	-0.166	1.975	-0.547	1.128	0.998	0.632	0.698	0.547	0.530	.	4.910	-1.230	-0.325	-0.699	-0.113	0.000	0.001	0.015	725	.	.	.	ID=COSV100457716;OCCURENCE=1(endometrium)	TLR10	62	0	139	21	0.13125	TRUE	NA
ENSG00000189184.11	.	BCM	GRCh38.p13	chr4	137521040	137521040	+	G	G	A	Missense_Mutation	SNP	ENST00000344876.8	exon4	c.C3397T	p.R1133C	exonic	ENSG00000189184.11	.	nonsynonymous SNV	ENSG00000189184.11:ENST00000344876.8:exon4:c.C3397T:p.R1133C	4q28.3	C3N-01167	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	L	T	D	0.910	T	T	D	0.248	0.400	0.852	0.632	D	T	D	D	D	D	4.352	30	0.999	D	D	0.590	5.826	0.605	6.282	1.000	0.707	0.588	0.725	0.528	.	5.090	5.090	3.435	1.172	0.614	1.000	1.000	0.997	954	.	.	.	ID=COSV61272057;OCCURENCE=1(skin)	PCDH18	30	0	56	17	0.232876712328767	TRUE	TRUE
ENSG00000205359.10	.	BCM	GRCh38.p13	chr5	102498772	102498772	+	C	C	T	Missense_Mutation	SNP	ENST00000506729.6	exon1	c.G73A	p.A25T	exonic	ENSG00000205359.10	.	nonsynonymous SNV	ENSG00000205359.10:ENST00000506729.6:exon1:c.G73A:p.A25T	5q21.1	C3N-01167	.	.	.	.	.	.	.	.	.	3.20	D	T	D	B	N	N	L	T	N	0.040	T	T	T	0.120	0.252	0.030	0.354	T	T	T	T	D	T	-1.144	0.003	0.903	N	N	-1.501	0.081	-1.718	0.048	0.319	0.422	0.574	0.600	0.613	.	2.880	-5.770	-3.709	-0.555	0.549	0.000	0.000	0.001	238	.	.	.	ID=COSV65808025;OCCURENCE=1(breast),1(oesophagus),1(large_intestine),2(pancreas)	SLCO6A1	144	0	397	85	0.176348547717842	TRUE	TRUE
ENSG00000254245.3	.	BCM	GRCh38.p13	chr5	141345546	141345546	+	G	G	A	Missense_Mutation	SNP	ENST00000253812.8	exon1	c.G1513A	p.V505I	exonic	ENSG00000254245.3	.	nonsynonymous SNV	ENSG00000254245.3:ENST00000253812.8:exon1:c.G1513A:p.V505I	5q31.3	C3N-01167	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	U	D	L	T	N	0.042	T	T	T	0.036	0.446	0.475	0.431	.	T	T	T	T	T	0.089	1.992	0.920	N	N	-1.080	0.324	-1.094	0.382	0.085	0.549	0.616	0.686	0.616	.	5.360	-3.500	-1.431	0.242	0.672	0.000	0.808	0.897	725	Cadherin-like	.	.	ID=COSV53891908;OCCURENCE=1(cervix),3(large_intestine),1(prostate)	PCDHGA3	315	0	667	135	0.168329177057357	TRUE	TRUE
ENSG00000253485.2	.	BCM	GRCh38.p13	chr5	141366006	141366006	+	C	C	T	Missense_Mutation	SNP	ENST00000518069.1	exon1	c.C1676T	p.T559M	exonic	ENSG00000253485.2	.	nonsynonymous SNV	ENSG00000253485.2:ENST00000518069.1:exon1:c.C1676T:p.T559M	5q31.3	C3N-01167	2.48e-05	0	0	0	0	4.495e-05	0	0	rs760966863	2.18	D	D	B	B	.	N	L	T	N	0.199	T	T	T	0.040	0.410	0.332	0.192	.	T	T	T	T	T	0.612	7.630	0.931	N	N	-1.117	0.292	-1.282	0.221	0.847	0.549	0.588	0.576	0.616	.	4.720	-5.000	-0.230	-1.331	-0.862	0.000	0.000	0.008	649	Cadherin_conserved_site;Cadherin-like	.	.	ID=COSV54003473;OCCURENCE=1(large_intestine),2(stomach),1(lung)	PCDHGA5	342	1	669	318	0.322188449848024	NA	TRUE
ENSG00000086570.12	.	BCM	GRCh38.p13	chr5	151543319	151543319	+	G	G	A	Missense_Mutation	SNP	ENST00000261800.5	exon9	c.C7808T	p.P2603L	exonic	ENSG00000086570.12	.	nonsynonymous SNV	ENSG00000086570.12:ENST00000261800.5:exon9:c.C7808T:p.P2603L	5q33.1	C3N-01167	2.471e-05	0	0.0002	0	0	1.498e-05	0	0	rs372313673	10.20	T	D	D	D	D	D	L	T	D	0.795	T	T	D	0.422	.	0.763	0.574	T	T	T	T	T	D	3.315	24.200	0.993	D	D	0.471	4.816	0.491	5.079	1.000	0.554	0.590	0.618	0.564	.	5.360	5.360	9.920	1.176	0.676	1.000	0.050	0.316	891	Cadherin-like	.	.	ID=COSV55822638;OCCURENCE=1(skin)	FAT2	179	0	320	168	0.344262295081967	TRUE	TRUE
ENSG00000164463.12	.	BCM	GRCh38.p13	chr5	173090407	173090407	+	T	T	A	Missense_Mutation	SNP	ENST00000296953.6	exon4	c.T228A	p.D76E	exonic	ENSG00000164463.12	.	nonsynonymous SNV	ENSG00000164463.12:ENST00000296953.6:exon4:c.T228A:p.D76E	5q35.1	C3N-01167	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	L	T	N	0.609	T	T	T	0.198	0.330	0.123	0.869	T	T	T	T	D	T	2.031	19.490	0.995	D	N	-0.135	2.066	0.085	2.673	1.000	0.732	0.744	0.602	0.636	.	5.780	5.780	2.140	1.138	0.665	1.000	1.000	0.999	963	.	.	.	.	CREBRF	126	0	342	71	0.171912832929782	TRUE	TRUE
ENSG00000204687.4	.	BCM	GRCh38.p13	chr6	29487479	29487479	+	C	C	T	Missense_Mutation	SNP	ENST00000377127.4	exon1	c.G424A	p.V142M	exonic	ENSG00000204687.4	.	nonsynonymous SNV	ENSG00000204687.4:ENST00000377127.4:exon1:c.G424A:p.V142M	6p22.1	C3N-01167	8.264e-06	0	0	0	0	1.504e-05	0	0	rs755412096	0.18	T	T	B	B	.	N	N	T	N	0.029	T	T	T	0.013	0.547	0.014	0.069	T	T	T	T	T	.	-0.095	0.850	0.573	N	N	-1.737	0.031	-1.844	0.028	0.115	0.487	0.574	0.574	0.564	.	2.130	-4.260	-1.083	-1.290	-2.172	0.000	0.140	0.000	824	GPCR,_rhodopsin-like,_7TM	.	.	.	MAS1L	157	0	400	65	0.139784946236559	TRUE	NA
ENSG00000124813.23	.	BCM	GRCh38.p13	chr6	45422893	45422893	+	A	A	G	Missense_Mutation	SNP	ENST00000647337.2	exon3	c.A359G	p.N120S	exonic	ENSG00000124813.23	.	nonsynonymous SNV	ENSG00000124813.23:ENST00000647337.2:exon3:c.A359G:p.N120S	6p21.1	C3N-01167	.	.	.	.	.	.	.	.	.	15.20	D	T	B	B	D	D	L	D	D	0.614	D	D	D	0.582	.	0.858	0.471	T	D	D	D	D	D	2.619	22.700	0.977	D	D	-0.087	2.216	-0.023	2.283	1.000	0.443	0.492	0.666	0.555	.	3.660	2.480	6.587	0.240	0.634	1.000	1.000	0.998	663	Runt_domain	.	.	.	RUNX2	277	0	549	274	0.332928311057108	TRUE	TRUE
ENSG00000112038.18	.	BCM	GRCh38.p13	chr6	154091094	154091094	+	G	G	C	Missense_Mutation	SNP	ENST00000330432.12	exon3	c.G786C	p.K262N	exonic	ENSG00000112038.18	.	nonsynonymous SNV	ENSG00000112038.18:ENST00000330432.12:exon3:c.G786C:p.K262N	6q25.2	C3N-01167	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	L	T	D	0.849	T	T	T	0.397	0.713	0.721	0.353	D	T	T	T	D	D	3.681	25.300	0.999	D	D	0.885	10.661	0.873	12.654	0.999	0.487	0.574	0.574	0.564	.	5.960	5.960	5.730	0.227	-0.103	1.000	1.000	0.993	953	GPCR,_rhodopsin-like,_7TM	.	.	.	OPRM1	304	1	494	207	0.295292439372325	TRUE	NA
ENSG00000158525.15	.	BCM	GRCh38.p13	chr7	130368538	130368538	+	C	C	G	Missense_Mutation	SNP	ENST00000485477.5	exon12	c.C1252G	p.Q418E	exonic	ENSG00000158525.15	.	nonsynonymous SNV	ENSG00000158525.15:ENST00000485477.5:exon12:c.C1252G:p.Q418E	7q32.2	C3N-01167	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	D	.	T	N	0.103	T	T	T	0.098	0.410	0.183	0.189	T	T	T	T	T	T	0.164	2.719	0.160	N	N	-1.073	0.331	-0.931	0.578	1.000	0.554	0.588	0.602	0.613	.	5.850	1.760	0.369	-0.291	-0.188	0.045	0.925	0.390	646	Peptidase_M14,_carboxypeptidase_A	.	.	.	CPA5	186	0	497	146	0.22706065318818	TRUE	TRUE
ENSG00000164756.12	.	BCM	GRCh38.p13	chr8	117157832	117157832	+	C	C	T	Missense_Mutation	SNP	ENST00000456015.6	exon4	c.C560T	p.A187V	exonic	ENSG00000164756.12	.	nonsynonymous SNV	ENSG00000164756.12:ENST00000456015.6:exon4:c.C560T:p.A187V	8q24.11	C3N-01167	0.0003	0	0.0003	0	0	0.0005	0	0	rs141202988	0.20	T	T	B	B	N	N	N	T	N	0.183	T	T	T	0.117	.	0.504	0.046	T	T	T	T	T	T	0.420	5.642	0.145	N	N	-0.791	0.667	-0.672	0.940	0.000	0.500	0.574	0.624	0.564	.	5.760	2.110	1.001	0.126	-0.173	0.444	0.889	0.109	949	.	.	.	ID=COSV69970408;OCCURENCE=1(liver),2(large_intestine),3(central_nervous_system),1(ovary),2(stomach),1(endometrium)	SLC30A8	78	0	421	62	0.128364389233954	TRUE	TRUE
ENSG00000122733.12	.	BCM	GRCh38.p13	chr9	34971624	34971624	+	G	G	A	Missense_Mutation	SNP	ENST00000242315.3	exon2	c.G326A	p.R109Q	exonic	ENSG00000122733.12	.	nonsynonymous SNV	ENSG00000122733.12:ENST00000242315.3:exon2:c.G326A:p.R109Q	9p13.3	C3N-01167	8.37e-06	0.0001	0	0	0	0	0	0	rs372641183	9.18	D	D	D	P	D	D	.	.	N	0.780	T	T	T	0.105	.	0.422	1.125	T	T	T	T	D	D	3.967	26.800	0.999	D	D	0.565	5.583	0.604	6.272	1.000	0.554	0.590	0.602	0.542	.	6.030	5.130	9.437	1.176	0.676	1.000	0.909	0.865	266	.	.	.	ID=COSV54273291;OCCURENCE=1(breast),1(large_intestine),1(stomach)	PHF24	83	0	830	88	0.0958605664488017	TRUE	TRUE
ENSG00000204246.3	.	BCM	GRCh38.p13	chr9	104536089	104536089	+	A	A	T	Missense_Mutation	SNP	ENST00000374781.2	exon1	c.T725A	p.M242K	exonic	ENSG00000204246.3	.	nonsynonymous SNV	ENSG00000204246.3:ENST00000374781.2:exon1:c.T725A:p.M242K	9q31.1	C3N-01167	.	.	.	.	.	.	.	.	.	4.20	D	D	B	B	U	N	L	T	D	0.257	T	T	T	0.189	0.776	0.559	0.015	T	T	T	T	D	T	1.999	19.250	0.937	N	N	-0.337	1.526	-0.339	1.487	0.000	0.487	0.574	0.574	0.564	.	4.180	4.180	1.328	1.312	0.691	0.000	0.997	0.974	666	GPCR,_rhodopsin-like,_7TM	.	.	.	OR13C3	168	0	551	203	0.269230769230769	TRUE	TRUE
ENSG00000130635.16	.	BCM	GRCh38.p13	chr9	134835097	134835097	+	G	G	A	Missense_Mutation	SNP	ENST00000371817.8	exon65	c.G5263A	p.A1755T	exonic	ENSG00000130635.16	.	nonsynonymous SNV	ENSG00000130635.16:ENST00000371817.8:exon65:c.G5263A:p.A1755T	9q34.3	C3N-01167	5.877e-05	0	8.728e-05	0.0007	0	0	0	0	rs776748227	3.20	T	T	P	B	U	D	L	T	N	0.464	T	T	T	0.189	0.434	0.649	0.287	T	T	T	T	T	T	2.850	23.100	0.985	D	D	0.337	3.978	0.430	4.581	1.000	0.672	0.659	0.723	0.711	.	5.030	5.030	6.035	1.176	0.676	1.000	0.979	0.977	805	Fibrillar_collagen,_C-terminal	.	.	ID=COSV65666442;OCCURENCE=3(stomach)	COL5A1	339	1	843	339	0.286802030456853	TRUE	NA
ENSG00000283787.1	.	BCM	GRCh38.p13	chr11	1889290	1889290	+	C	C	T	Missense_Mutation	SNP	ENST00000640310.1	exon1	c.G1295A	p.R432H	exonic	ENSG00000283787.1	.	nonsynonymous SNV	ENSG00000283787.1:ENST00000640310.1:exon1:c.G1295A:p.R432H	11p15.5	C3N-01167	.	.	.	.	.	.	.	.	.	2.10	.	.	.	.	.	D	.	.	.	.	T	T	D	0.044	0.338	.	.	.	.	T	T	T	T	1.326	14.570	0.971	N	N	-0.284	1.654	-0.385	1.400	1.000	0.461	0.577	0.578	0.563	.	3.410	1.290	0.650	0.910	0.530	0.003	0.809	0.209	982	.	.	.	ID=COSV100289042;OCCURENCE=1(stomach)	PRR33	61	0	205	33	0.138655462184874	TRUE	NA
ENSG00000064201.16	.	BCM	GRCh38.p13	chr11	2314539	2314539	+	G	G	A	Missense_Mutation	SNP	ENST00000182290.9	exon6	c.G511A	p.D171N	exonic	ENSG00000064201.16	.	nonsynonymous SNV	ENSG00000064201.16:ENST00000182290.9:exon6:c.G511A:p.D171N	11p15.5	C3N-01167	.	.	.	.	.	.	.	.	.	1.20	T	T	P	P	N	N	L	T	N	0.090	T	T	D	0.241	0.226	0.736	0.038	T	T	T	T	T	T	0.618	7.688	0.989	N	N	-0.744	0.740	-0.941	0.565	0.943	0.581	0.574	0.578	0.605	.	3.570	0.325	-0.543	-0.530	-0.196	0.000	0.000	0.001	988	.	.	.	.	TSPAN32	228	0	508	131	0.205007824726135	TRUE	TRUE
ENSG00000184350.11	.	BCM	GRCh38.p13	chr11	3227890	3227890	+	G	G	A	Missense_Mutation	SNP	ENST00000389832.7	exon2	c.C910T	p.R304C	exonic	ENSG00000184350.11	.	nonsynonymous SNV	ENSG00000184350.11:ENST00000389832.7:exon2:c.C910T:p.R304C	11p15.4	C3N-01167	.	.	.	.	.	.	.	.	rs994216531	0.18	T	T	.	.	U	N	N	T	N	0.227	T	T	T	0.059	.	0.349	.	T	T	T	T	T	T	2.150	20.500	0.987	N	N	-0.383	1.421	-0.449	1.286	0.992	0.487	0.574	0.578	0.613	.	3.380	2.390	0.039	0.191	-0.106	0.000	0.001	0.891	976	.	.	.	.	MRGPRE	13	0	37	10	0.212765957446809	TRUE	NA
ENSG00000110514.19	.	BCM	GRCh38.p13	chr11	47285542	47285542	+	G	G	A	Missense_Mutation	SNP	ENST00000311027.9	exon14	c.G2503A	p.V835I	exonic	ENSG00000110514.19	.	nonsynonymous SNV	ENSG00000110514.19:ENST00000311027.9:exon14:c.G2503A:p.V835I	11p11.2	C3N-01167	8.26e-06	0	0	0	0	1.502e-05	0	0	rs760678538	3.20	T	T	B	B	N	D	N	T	N	0.165	T	T	T	0.096	.	0.157	0.073	T	T	T	T	T	D	0.889	10.320	0.936	D	N	-0.685	0.838	-0.488	1.222	0.258	0.707	0.702	0.725	0.714	.	6.170	1.260	0.931	-0.122	-0.106	0.998	0.997	0.997	19	.	.	.	.	MADD	183	0	323	180	0.357852882703777	TRUE	NA
ENSG00000149256.16	.	BCM	GRCh38.p13	chr11	78672142	78672142	+	C	C	T	Missense_Mutation	SNP	ENST00000278550.12	exon31	c.G5684A	p.G1895D	exonic	ENSG00000149256.16	.	nonsynonymous SNV	ENSG00000149256.16:ENST00000278550.12:exon31:c.G5684A:p.G1895D	11q14.1	C3N-01167	.	.	.	.	.	.	.	.	.	17.20	T	D	D	D	D	D	L	D	D	0.954	D	D	D	0.617	0.575	0.531	0.806	T	D	D	D	D	D	3.852	26.100	0.998	D	D	0.739	7.701	0.728	8.314	1.000	0.646	0.574	0.645	0.563	.	5.550	5.550	6.170	1.026	0.599	1.000	0.985	0.967	882	.	.	.	.	TENM4	300	0	546	258	0.32089552238806	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227341	25227341	+	T	T	G	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A183C	p.Q61H	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A183C:p.Q61H	12p12.1	C3N-01167	.	.	.	.	.	.	.	.	rs17851045	17.20	D	D	B	B	D	D	M	D	D	0.760	D	D	D	0.644	0.659	0.905	1.857	D	D	D	D	D	T	2.993	23.400	0.997	D	D	0.298	3.768	0.383	4.239	0.998	0.722	0.710	0.710	0.735	.	5.770	5.770	2.812	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55498802;OCCURENCE=2(breast),6(liver),1(genital_tract),1(cervix),117(large_intestine),2(central_nervous_system),17(biliary_tract),3(ovary),8(stomach),50(haematopoietic_and_lymphoid_tissue),2(urinary_tract),1(kidney),71(pancreas),2(skin),2(prostate),28(lung),1(thyroid),2(small_intestine),5(endometrium)	KRAS	159	1	337	172	0.337917485265226	TRUE	TRUE
ENSG00000180263.14	.	BCM	GRCh38.p13	chr12	95172626	95172626	+	C	C	G	Missense_Mutation	SNP	ENST00000343958.9	exon3	c.G2560C	p.E854Q	exonic	ENSG00000180263.14	.	nonsynonymous SNV	ENSG00000180263.14:ENST00000343958.9:exon3:c.G2560C:p.E854Q	12q22	C3N-01167	.	.	.	.	.	.	.	.	.	7.20	D	T	D	P	N	D	M	T	N	0.109	T	T	T	0.134	0.174	0.617	0.453	T	T	T	T	D	T	3.397	24.400	0.953	D	D	0.513	5.138	0.548	5.625	1.000	0.722	0.588	0.710	0.735	.	5.940	5.940	4.121	1.026	0.599	1.000	0.981	0.973	881	.	.	.	.	FGD6	81	0	162	88	0.352	TRUE	TRUE
ENSG00000139767.10	.	BCM	GRCh38.p13	chr12	119102258	119102258	+	G	G	A	Missense_Mutation	SNP	ENST00000267260.5	exon2	c.G154A	p.V52I	exonic	ENSG00000139767.10	.	nonsynonymous SNV	ENSG00000139767.10:ENST00000267260.5:exon2:c.G154A:p.V52I	12q24.23	C3N-01167	0.0002	0.0001	0	0	0	0.0004	0	6.137e-05	rs118023042	0.20	T	T	B	B	N	N	N	T	N	0.057	T	T	T	0.007	.	0.014	0.122	T	T	T	T	T	T	-1.410	0.001	0.722	N	N	-1.738	0.031	-1.853	0.027	1.000	0.660	0.574	0.696	0.564	.	4.830	-9.650	-2.232	-3.593	-1.475	0.000	0.000	0.005	944	.	.	.	.	SRRM4	66	0	224	53	0.191335740072202	TRUE	NA
ENSG00000111452.13	.	BCM	GRCh38.p13	chr12	131084604	131084604	+	G	G	A	Missense_Mutation	SNP	ENST00000261654.10	exon15	c.G1612A	p.V538I	exonic	ENSG00000111452.13	.	nonsynonymous SNV	ENSG00000111452.13:ENST00000261654.10:exon15:c.G1612A:p.V538I	12q24.33	C3N-01167	4.971e-05	0	8.667e-05	0.0001	0	4.526e-05	0	6.063e-05	rs200971352	1.18	T	T	B	B	N	N	.	T	N	0.129	T	T	D	0.137	.	0.076	0.134	T	T	T	T	T	T	-0.954	0.010	0.823	.	N	-2.007	0.009	-2.035	0.011	0.376	0.554	0.588	0.578	0.613	.	4.990	-6.860	-0.108	-3.259	-2.868	0.001	0.000	0.096	988	GPS_motif	.	.	ID=COSV55440249;OCCURENCE=1(oesophagus),2(large_intestine),1(stomach),1(pancreas)	ADGRD1	270	0	465	198	0.298642533936652	TRUE	TRUE
ENSG00000198033.12	.	BCM	GRCh38.p13	chr13	19177009	19177009	+	G	G	A	Missense_Mutation	SNP	ENST00000400113.8	exon4	c.C974T	p.P325L	exonic	ENSG00000198033.12	.	nonsynonymous SNV	ENSG00000198033.12:ENST00000400113.8:exon4:c.C974T:p.P325L	13q12.11	C3N-01167	8.237e-06	0	8.637e-05	0	0	0	0	0	rs572405672	9.16	.	D	.	.	U	D	H	D	D	0.489	T	D	T	0.413	0.760	0.721	1.612	T	.	T	T	D	D	3.550	24.900	0.988	D	N	-0.131	2.078	-0.221	1.737	0.009	0.487	0.574	0.547	0.613	.	1.210	0.295	5.243	0.685	0.340	1.000	0.701	0.073	988	Tubulin/FtsZ,_2-layer_sandwich_domain	.	.	ID=COSV68029607;OCCURENCE=1(thyroid)	TUBA3C	230	1	775	242	0.23795476892822	NA	TRUE
ENSG00000102738.8	.	BCM	GRCh38.p13	chr13	40771109	40771109	+	-	NA	TT	Frame_Shift_Ins	INS	ENST00000323563.8	exon1	c.27_28insAA	p.P10Nfs*57	exonic	ENSG00000102738.8	.	frameshift insertion	ENSG00000102738.8:ENST00000323563.8:exon1:c.27_28insAA:p.P10Nfs*57	13q14.11	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MRPS31	NA	NA	NA	NA	NA	NA	NA
ENSG00000047346.12	.	BCM	GRCh38.p13	chr15	52609869	52609869	+	G	G	A	Missense_Mutation	SNP	ENST00000261844.11	exon6	c.C1045T	p.R349C	exonic	ENSG00000047346.12	.	nonsynonymous SNV	ENSG00000047346.12:ENST00000261844.11:exon6:c.C1045T:p.R349C	15q21.3	C3N-01167	3.5e-05	0.0003	0	0	0	1.592e-05	0	0	rs201191117	0.20	T	T	B	B	N	N	L	T	N	0.071	T	T	T	0.074	.	0.234	0.123	T	T	T	T	T	T	1.442	15.360	0.840	N	N	-0.900	0.520	-0.877	0.652	0.073	0.707	0.654	0.659	0.714	.	5.370	-1.230	0.369	0.245	0.676	0.000	0.951	0.894	333	.	.	.	ID=COSV55927930;OCCURENCE=1(liver)	FAM214A	156	0	282	47	0.142857142857143	TRUE	TRUE
ENSG00000066813.14	.	BCM	GRCh38.p13	chr16	20543253	20543253	+	C	C	G	Missense_Mutation	SNP	ENST00000329697.10	exon11	c.G1291C	p.D431H	exonic	ENSG00000066813.14	.	nonsynonymous SNV	ENSG00000066813.14:ENST00000329697.10:exon11:c.G1291C:p.D431H	16p12.3	C3N-01167	.	.	.	.	.	.	.	.	.	2.20	D	D	B	B	N	N	L	T	N	0.346	T	T	T	0.135	0.559	0.169	0.306	T	T	T	T	T	T	1.279	14.230	0.878	N	N	-1.200	0.227	-1.397	0.153	0.000	0.487	0.590	0.492	0.564	.	3.260	-6.350	0.036	-0.488	-0.542	0.005	0.005	0.003	764	AMP-dependent_synthetase/ligase	.	.	.	ACSM2B	95	0	389	61	0.135555555555556	NA	TRUE
ENSG00000080603.17	.	BCM	GRCh38.p13	chr16	30707352	30707352	+	G	G	T	Missense_Mutation	SNP	ENST00000380361.7	exon2	c.G419T	p.R140L	exonic	ENSG00000080603.17;ENSG00000282034.1	.	nonsynonymous SNV	ENSG00000282034.1:ENST00000380361.7:exon2:c.G419T:p.R140L,ENSG00000080603.17:ENST00000262518.9:exon5:c.G476T:p.R159L	16p11.2	C3N-01167	.	.	.	.	.	.	.	.	rs993440316	13.20	T	T	P	P	D	D	L	D	D	0.467	D	D	D	0.718	0.558	0.660	1.620	D	T	D	D	D	T	3.622	25.100	0.987	D	D	0.320	3.886	0.371	4.160	1.000	0.672	0.702	0.702	0.711	.	5.290	4.310	5.625	1.176	0.676	1.000	1.000	0.969	10	Helicase/SANT-associated_domain	.	.	.	SRCAP	96	1	252	116	0.315217391304348	TRUE	TRUE
ENSG00000169896.18	.	BCM	GRCh38.p13	chr16	31297859	31297859	+	G	G	A	Missense_Mutation	SNP	ENST00000544665.9	exon14	c.G1612A	p.V538M	exonic	ENSG00000169896.18	.	nonsynonymous SNV	ENSG00000169896.18:ENST00000544665.9:exon14:c.G1612A:p.V538M	16p11.2	C3N-01167	.	.	.	.	.	.	.	.	.	16.19	D	D	D	D	.	D	M	T	D	0.680	D	D	D	0.557	0.717	0.901	0.991	T	D	D	T	D	D	3.811	25.900	0.999	D	D	0.746	7.820	0.632	6.647	0.999	0.615	0.634	0.618	0.613	.	3.760	3.760	4.152	1.155	0.676	1.000	0.988	0.995	268	.	.	.	.	ITGAM	116	0	258	93	0.264957264957265	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673582	7673583	+	GA	GA	-	Frame_Shift_Del	DEL	ENST00000269305.8	exon9	c.945_946del	p.Q317Afs*19	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon9:c.945_946del:p.Q317Afs*19	17p13.1	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	261	0	430	282	0.396067415730337	TRUE	TRUE
ENSG00000196156.5	.	BCM	GRCh38.p13	chr17	41167961	41167961	+	C	C	T	Missense_Mutation	SNP	ENST00000391356.4	exon1	c.G212A	p.R71H	exonic	ENSG00000196156.5	.	nonsynonymous SNV	ENSG00000196156.5:ENST00000391356.4:exon1:c.G212A:p.R71H	17q21.2	C3N-01167	.	.	.	.	.	.	.	.	.	1.19	T	T	P	B	.	N	M	T	N	0.040	T	T	T	0.053	0.477	0.164	0.026	T	T	T	T	T	T	0.665	8.129	0.965	N	N	-0.551	1.077	-0.652	0.969	0.000	0.497	0.590	0.316	0.613	.	4.460	1.320	-3.085	-0.966	-0.304	0.000	0.032	0.437	266	.	.	.	ID=COSV101194142;OCCURENCE=1(large_intestine),1(central_nervous_system),1(pancreas)	KRTAP4-3	303	0	460	202	0.305135951661631	TRUE	NA
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51067141	51067157	+	CACCTGGAGATGCTGTT	CACCTGGAGATGCTGTT	-	Nonsense_Mutation	DEL	ENST00000342988.8	exon10	c.1262_1278del	p.P422*	exonic	ENSG00000141646.14	.	stopgain	ENSG00000141646.14:ENST00000342988.8:exon10:c.1262_1278del:p.P422*	18q21.2	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMAD4	291	0	427	109	0.203358208955224	TRUE	TRUE
ENSG00000187323.12	.	BCM	GRCh38.p13	chr18	53207763	53207763	+	C	C	T	Missense_Mutation	SNP	ENST00000442544.7	exon11	c.C1807T	p.R603C	exonic	ENSG00000187323.12	.	nonsynonymous SNV	ENSG00000187323.12:ENST00000442544.7:exon11:c.C1807T:p.R603C	18q21.2	C3N-01167	4.119e-05	0	0	0	0.0006	1.498e-05	0	0	rs267605206	16.20	D	D	D	D	D	D	M	T	D	0.759	T	T	D	0.412	0.682	0.786	0.854	D	T	D	D	D	D	4.243	29.100	0.992	D	D	0.780	8.400	0.755	8.927	0.049	0.487	0.574	0.574	0.564	.	5.830	5.830	3.568	1.026	0.599	1.000	0.949	0.926	715	Fibronectin_type_III	.	.	ID=COSV59087112;OCCURENCE=1(large_intestine),1(skin),1(thyroid),1(endometrium)	DCC	311	0	388	102	0.208163265306122	TRUE	TRUE
ENSG00000196172.9	.	BCM	GRCh38.p13	chr19	23745169	23745169	+	A	A	C	Nonsense_Mutation	SNP	ENST00000402377.3	exon4	c.T381G	p.Y127X	exonic	ENSG00000196172.9	.	stopgain	ENSG00000196172.9:ENST00000402377.3:exon4:c.T381G:p.Y127X	19p12	C3N-01167	.	.	.	.	.	.	.	.	.	1.5	.	.	.	.	.	D	.	.	.	0.014	.	.	.	.	.	.	.	.	.	T	T	.	.	3.410	24.400	0.888	N	N	-0.762	0.712	-1.205	0.279	0.000	0.615	0.588	0.659	0.564	.	1.230	-2.460	-2.328	-1.543	-0.711	0.000	0.072	0.029	988	.	.	.	.	ZNF681	109	0	282	22	0.0723684210526316	TRUE	TRUE
ENSG00000196218.13	.	BCM	GRCh38.p13	chr19	38490122	38490122	+	G	G	A	Missense_Mutation	SNP	ENST00000359596.8	exon36	c.G5861A	p.R1954H	exonic	ENSG00000196218.13	.	nonsynonymous SNV	ENSG00000196218.13:ENST00000359596.8:exon36:c.G5861A:p.R1954H	19q13.2	C3N-01167	8.278e-06	0	0	0	0	1.507e-05	0	0	rs775643457	17.19	D	.	D	D	U	D	M	T	D	0.838	D	D	D	0.763	0.621	0.990	0.758	D	D	D	D	D	D	4.434	31	0.999	D	D	0.871	10.332	0.806	10.301	1.000	0.707	0.593	0.725	0.613	.	4.610	4.610	9.903	1.172	0.671	1.000	0.992	0.993	746	.	.	.	.	RYR1	419	0	1071	359	0.251048951048951	TRUE	NA
ENSG00000182393.3	.	BCM	GRCh38.p13	chr19	39296516	39296516	+	A	A	G	Missense_Mutation	SNP	ENST00000333625.3	exon1	c.A95G	p.K32R	exonic	ENSG00000182393.3	.	nonsynonymous SNV	ENSG00000182393.3:ENST00000333625.3:exon1:c.A95G:p.K32R	19q13.2	C3N-01167	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.071	T	T	T	0.010	0.286	0.030	0.061	T	T	T	T	T	T	-0.774	0.029	0.289	N	N	-1.966	0.011	-2.007	0.013	0.988	0.497	0.590	0.547	0.542	.	4.590	-9.180	-1.166	-0.641	-0.140	0.000	0.002	0.018	608	.	.	.	.	IFNL1	155	0	348	101	0.224944320712695	TRUE	TRUE
ENSG00000183035.13	.	BCM	GRCh38.p13	chrX	83874548	83874548	+	C	C	A	Missense_Mutation	SNP	ENST00000329312.5	exon4	c.C1840A	p.P614T	exonic	ENSG00000183035.13	.	nonsynonymous SNV	ENSG00000183035.13:ENST00000329312.5:exon4:c.C1840A:p.P614T	Xq21.1	C3N-01167	.	.	.	.	.	.	.	.	.	1.18	T	T	P	B	.	N	L	T	D	0.358	T	T	T	0.119	0.118	0.110	0.003	T	T	T	T	T	T	0.137	2.439	0.841	N	.	.	.	.	.	0.000	.	.	.	.	.	3.480	0.596	0.114	-0.231	-0.174	0.478	0.173	0.688	620	.	.	.	ID=COSV100254500;OCCURENCE=1(lung)	CYLC1	157	0	401	69	0.146808510638298	TRUE	TRUE
ENSG00000182195.9	.	BCM	GRCh38.p13	chrX	141176917	141176917	+	G	G	T	Nonsense_Mutation	SNP	ENST00000370526.5	exon1	c.C105A	p.C35X	exonic	ENSG00000182195.9	.	stopgain	ENSG00000182195.9:ENST00000370526.5:exon1:c.C105A:p.C35X	Xq27.1	C3N-01167	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	N	D	.	.	.	0.806	.	.	.	.	.	.	.	.	.	D	D	.	.	6.526	36	0.993	N	.	.	.	.	.	1.000	.	.	.	.	.	3.610	2.720	1.584	-0.103	-0.190	1.000	0.998	0.994	987	Domain_of_unknown_function_DUF4939	.	.	.	LDOC1	189	0	583	209	0.263888888888889	TRUE	TRUE
ENSG00000178104.19	.	BCM	GRCh38.p13	chr1	149027526	149027526	+	C	C	T	Silent	SNP	ENST00000369354.7	exon40	c.C6568T	p.L2190L	exonic	ENSG00000178104.19	.	synonymous SNV	ENSG00000178104.19:ENST00000369354.7:exon40:c.C6568T:p.L2190L	1q21.2	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57720123;OCCURENCE=1(skin)	PDE4DIP	20	0	66	57	0.463414634146341	NA	TRUE
ENSG00000133063.16	.	BCM	GRCh38.p13	chr1	203225758	203225758	+	G	G	A	Silent	SNP	ENST00000367229.6	exon3	c.C168T	p.Y56Y	exonic	ENSG00000133063.16	.	synonymous SNV	ENSG00000133063.16:ENST00000367229.6:exon3:c.C168T:p.Y56Y	1q32.1	C3N-01167	6.591e-05	0.0006	0	0.0001	0	0	0	6.056e-05	rs149551689	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CHIT1	500	1	1714	255	0.129507364144236	TRUE	NA
ENSG00000197591.3	.	BCM	GRCh38.p13	chr1	247841063	247841063	+	G	G	A	Silent	SNP	ENST00000355784.3	exon1	c.C834T	p.Y278Y	exonic	ENSG00000197591.3	.	synonymous SNV	ENSG00000197591.3:ENST00000355784.3:exon1:c.C834T:p.Y278Y	1q44	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR11L1	167	0	858	51	0.0561056105610561	TRUE	TRUE
ENSG00000119778.15	.	BCM	GRCh38.p13	chr2	23864826	23864826	+	A	A	G	Silent	SNP	ENST00000238789.10	exon11	c.T1287C	p.F429F	exonic	ENSG00000119778.15	.	synonymous SNV	ENSG00000119778.15:ENST00000238789.10:exon11:c.T1287C:p.F429F	2p23.3	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATAD2B	92	0	192	42	0.179487179487179	TRUE	TRUE
ENSG00000121988.18	.	BCM	GRCh38.p13	chr2	135315485	135315485	+	A	A	G	Silent	SNP	ENST00000264159.11	exon7	c.T723C	p.N241N	exonic	ENSG00000121988.18	.	synonymous SNV	ENSG00000121988.18:ENST00000264159.11:exon7:c.T723C:p.N241N	2q21.3	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZRANB3	57	0	125	43	0.255952380952381	TRUE	TRUE
ENSG00000114841.17	.	BCM	GRCh38.p13	chr3	52370590	52370590	+	C	C	T	Silent	SNP	ENST00000420323.6	exon40	c.C6372T	p.R2124R	exonic	ENSG00000114841.17	.	synonymous SNV	ENSG00000114841.17:ENST00000420323.6:exon40:c.C6372T:p.R2124R	3p21.1	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH1	218	0	376	206	0.353951890034364	TRUE	TRUE
ENSG00000081148.12	.	BCM	GRCh38.p13	chr3	101229485	101229485	+	G	G	A	Silent	SNP	ENST00000193391.8	exon17	c.C3528T	p.P1176P	exonic	ENSG00000081148.12	.	synonymous SNV	ENSG00000081148.12:ENST00000193391.8:exon17:c.C3528T:p.P1176P	3q12.3	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IMPG2	203	0	349	190	0.352504638218924	TRUE	TRUE
ENSG00000188848.16	.	BCM	GRCh38.p13	chr4	42143656	42143656	+	G	G	A	Silent	SNP	ENST00000502486.6	exon3	c.C826T	p.L276L	exonic	ENSG00000188848.16	.	synonymous SNV	ENSG00000188848.16:ENST00000502486.6:exon3:c.C826T:p.L276L	4p13	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BEND4	136	0	505	82	0.1396933560477	TRUE	TRUE
ENSG00000168491.10	.	BCM	GRCh38.p13	chr4	185458523	185458523	+	A	A	G	Silent	SNP	ENST00000307588.8	exon6	c.T2064C	p.S688S	exonic	ENSG00000168491.10	.	synonymous SNV	ENSG00000168491.10:ENST00000307588.8:exon6:c.T2064C:p.S688S	4q35.1	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC110	93	0	138	29	0.173652694610778	TRUE	NA
ENSG00000121898.13	.	BCM	GRCh38.p13	chr10	123768610	123768610	+	C	C	T	Silent	SNP	ENST00000241305.4	exon9	c.G1215A	p.A405A	exonic	ENSG00000121898.13	.	synonymous SNV	ENSG00000121898.13:ENST00000241305.4:exon9:c.G1215A:p.A405A	10q26.13	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CPXM2	126	0	224	208	0.481481481481481	TRUE	NA
ENSG00000149016.16	.	BCM	GRCh38.p13	chr11	62578833	62578833	+	G	G	A	Silent	SNP	ENST00000476907.6	exon5	c.C888T	p.S296S	exonic	ENSG00000149016.16;ENSG00000255508.7	.	synonymous SNV	ENSG00000149016.16:ENST00000476907.6:exon5:c.C888T:p.S296S,ENSG00000255508.7:ENST00000496634.2:exon5:c.C888T:p.S296S	11q12.3	C3N-01167	1.651e-05	0	0	0	0	1.501e-05	0	6.089e-05	rs376134412	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TUT1	121	0	202	40	0.165289256198347	TRUE	NA
ENSG00000165617.14	.	BCM	GRCh38.p13	chr14	58646915	58646915	+	C	C	T	Silent	SNP	ENST00000335867.4	exon4	c.C2292T	p.G764G	exonic	ENSG00000165617.14	.	synonymous SNV	ENSG00000165617.14:ENST00000335867.4:exon4:c.C2292T:p.G764G	14q23.1	C3N-01167	8.239e-05	9.617e-05	0	0	0	0.0001	0.0011	0	rs140041218	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DACT1	218	0	393	66	0.143790849673203	TRUE	NA
ENSG00000007545.16	.	BCM	GRCh38.p13	chr16	1655951	1655951	+	G	G	A	Silent	SNP	ENST00000397412.8	exon10	c.G1194A	p.L398L	exonic	ENSG00000007545.16	.	synonymous SNV	ENSG00000007545.16:ENST00000397412.8:exon10:c.G1194A:p.L398L	16p13.3	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CRAMP1	117	0	320	164	0.338842975206612	TRUE	TRUE
ENSG00000276231.5	.	BCM	GRCh38.p13	chr17	8837809	8837809	+	G	G	A	Silent	SNP	ENST00000619866.5	exon5	c.C252T	p.L84L	exonic	ENSG00000276231.5	.	synonymous SNV	ENSG00000276231.5:ENST00000619866.5:exon5:c.C252T:p.L84L	17p13.1	C3N-01167	8.296e-06	0	0	0	0	1.501e-05	0	0	rs373458593	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PIK3R6	125	0	143	122	0.460377358490566	TRUE	NA
ENSG00000101493.11	.	BCM	GRCh38.p13	chr18	76442647	76442647	+	G	G	A	Silent	SNP	ENST00000443185.7	exon3	c.C408T	p.G136G	exonic	ENSG00000101493.11	.	synonymous SNV	ENSG00000101493.11:ENST00000443185.7:exon3:c.C408T:p.G136G	18q23	C3N-01167	3.378e-05	0.0003	0	0	0	0	0	8.422e-05	rs773122359	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV71587445;OCCURENCE=1(stomach)	ZNF516	144	0	245	75	0.234375	TRUE	TRUE
ENSG00000171804.11	.	BCM	GRCh38.p13	chr19	37889822	37889822	+	G	G	A	Silent	SNP	ENST00000447313.7	exon6	c.C3849T	p.D1283D	exonic	ENSG00000171804.11	.	synonymous SNV	ENSG00000171804.11:ENST00000447313.7:exon6:c.C3849T:p.D1283D	19q13.13	C3N-01167	0	0	0	0	0	0	0	0	rs544768229	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WDR87	130	0	444	132	0.229166666666667	TRUE	NA
ENSG00000101331.17	.	BCM	GRCh38.p13	chr20	32031164	32031164	+	G	G	A	Silent	SNP	ENST00000452892.3	exon10	c.G1566A	p.A522A	exonic	ENSG00000101331.17	.	synonymous SNV	ENSG00000101331.17:ENST00000452892.3:exon10:c.G1566A:p.A522A	20q11.21	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCM2L	185	0	509	84	0.141652613827993	TRUE	TRUE
ENSG00000237298.10	.	BCM	GRCh38.p13	chr2	178750139	178750139	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000237298.10	.	.	.	2q31.2	C3N-01167	.	.	.	.	.	.	.	.	.	0.16	T	T	B	B	.	N	.	T	N	0.109	T	T	T	0.047	0.387	0.030	.	.	.	T	T	T	T	-0.379	0.213	0.949	N	N	-1.484	0.086	-1.558	0.088	0.998	0.549	0.574	0.574	0.616	.	5.760	-6.430	-1.156	-0.610	-0.633	0.000	0.000	0.001	341	.	.	.	.	TTN-AS1	192	0	449	157	0.259075907590759	TRUE	NA
ENSG00000254588.1	.	BCM	GRCh38.p13	chr11	128527056	128527056	+	T	T	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000254588.1	.	.	.	11q24.3	C3N-01167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ETS1-AS1	49	0	86	25	0.225225225225225	TRUE	NA
ENSG00000140848.17	.	BCM	GRCh38.p13	chr16	57094074	57094074	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000140848.17	.	.	.	16q13	C3N-01167	.	.	.	.	.	.	.	.	rs778148063	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99321214;OCCURENCE=1(cervix),1(skin)	CPNE2	189	0	437	139	0.241319444444444	TRUE	NA
ENSG00000047644.19	.	BCM	GRCh38.p13	chrX	10117697	10117697	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000047644.19	.	.	.	Xp22.2	C3N-01167	5.853e-05	0	0	0	0	0.0001	0	0	rs763486319	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WWC3	71	0	139	60	0.301507537688442	TRUE	NA
ENSG00000117724.13	.	BCM	GRCh38.p13	chr1	214641403	214641403	+	A	A	T	Missense_Mutation	SNP	ENST00000366955.8	exon12	c.A3065T	p.K1022I	exonic	ENSG00000117724.13	.	nonsynonymous SNV	ENSG00000117724.13:ENST00000366955.8:exon12:c.A3065T:p.K1022I	1q41	C3L-01971	.	.	.	.	.	.	.	.	.	4.19	D	D	D	P	N	N	.	T	N	0.209	T	T	T	0.091	0.320	0.300	0.110	T	T	T	T	D	T	1.676	16.870	0.985	N	N	-0.469	1.238	-0.617	1.021	0.780	0.732	0.725	0.651	0.728	.	4.860	-1.530	0.292	-0.888	-0.074	0.061	0.329	0.971	899	.	.	.	.	CENPF	87	0	170	21	0.109947643979058	TRUE	TRUE
ENSG00000079308.19	.	BCM	GRCh38.p13	chr2	217818025	217818025	+	C	C	T	Missense_Mutation	SNP	ENST00000171887.8	exon24	c.G3995A	p.R1332Q	exonic	ENSG00000079308.19	.	nonsynonymous SNV	ENSG00000079308.19:ENST00000171887.8:exon24:c.G3995A:p.R1332Q	2q35	C3L-01971	1.398e-05	0	0	0	0	2.52e-05	0	0	rs747091639	8.20	D	T	B	B	N	D	L	D	N	0.208	T	D	D	0.145	0.306	0.560	0.147	T	T	T	T	T	D	2.476	22.400	0.997	D	D	-0.222	1.815	-0.128	1.968	1.000	0.707	0.610	0.659	0.714	.	5.100	3.260	2.279	0.104	0.599	0.961	0.867	0.604	944	.	.	.	.	TNS1	150	0	379	29	0.071078431372549	TRUE	NA
ENSG00000221944.8	.	BCM	GRCh38.p13	chr2	232549438	232549438	+	T	T	G	Missense_Mutation	SNP	ENST00000408957.6	exon1	c.A445C	p.K149Q	exonic	ENSG00000221944.8	.	nonsynonymous SNV	ENSG00000221944.8:ENST00000408957.6:exon1:c.A445C:p.K149Q	2q37.1	C3L-01971	.	.	.	.	.	.	.	.	.	1.19	T	T	P	P	.	N	M	T	N	0.086	T	T	T	0.045	0.387	0.602	.	T	T	T	T	T	T	2.400	22.100	0.871	N	N	-0.409	1.363	-0.642	0.984	0.999	0.635	0.628	0.644	0.605	.	0.556	0.556	0.446	0.737	0.661	0.544	0.453	0.605	917	HTH_CenpB-type_DNA-binding_domain	.	.	.	TIGD1	41	0	96	20	0.172413793103448	NA	TRUE
ENSG00000038219.13	.	BCM	GRCh38.p13	chr4	13603491	13603491	+	T	T	-	Frame_Shift_Del	DEL	ENST00000040738.10	exon10	c.3409delA	p.T1137Pfs*18	exonic	ENSG00000038219.13	.	frameshift deletion	ENSG00000038219.13:ENST00000040738.10:exon10:c.3409delA:p.T1137Pfs*18	4p15.33	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BOD1L1	170	0	280	20	0.0666666666666667	NA	TRUE
ENSG00000172403.11	.	BCM	GRCh38.p13	chr4	119027234	119027234	+	G	G	A	Missense_Mutation	SNP	ENST00000429713.7	exon3	c.G865A	p.D289N	exonic	ENSG00000172403.11	.	nonsynonymous SNV	ENSG00000172403.11:ENST00000429713.7:exon3:c.G865A:p.D289N	4q26	C3L-01971	8.251e-06	0	0	0	0	0	0	6.058e-05	rs756133104	3.20	T	T	B	B	N	D	L	T	N	0.131	T	T	T	0.077	0.283	0.082	0.089	T	T	T	T	T	T	2.652	22.700	0.998	D	D	0.223	3.404	0.303	3.732	1.000	0.659	0.574	0.725	0.542	.	4.680	4.680	3.555	1.176	0.676	1.000	0.905	0.970	576	.	.	.	ID=COSV61107334;OCCURENCE=1(large_intestine)	SYNPO2	159	0	300	20	0.0625	TRUE	TRUE
ENSG00000113205.5	.	BCM	GRCh38.p13	chr5	141102820	141102820	+	G	G	A	Missense_Mutation	SNP	ENST00000231130.3	exon1	c.G2171A	p.R724H	exonic	ENSG00000113205.5	.	nonsynonymous SNV	ENSG00000113205.5:ENST00000231130.3:exon1:c.G2171A:p.R724H	5q31.3	C3L-01971	.	.	.	.	.	.	.	.	.	1.14	T	T	.	.	.	N	.	T	N	0.077	T	T	T	0.091	0.495	0.334	.	T	.	T	T	D	T	0.673	8.210	0.996	N	.	-0.421	1.338	-0.640	0.987	0.000	0.693	0.574	0.659	0.621	.	4.140	2.020	-0.871	0.140	-0.390	0.000	0.404	0.057	491	.	.	.	ID=COSV99166913;OCCURENCE=1(endometrium)	PCDHB3	193	0	364	102	0.218884120171674	NA	TRUE
ENSG00000253159.3	.	BCM	GRCh38.p13	chr5	141432627	141432627	+	C	C	T	Missense_Mutation	SNP	ENST00000252085.4	exon1	c.C1868T	p.T623M	exonic	ENSG00000253159.3	.	nonsynonymous SNV	ENSG00000253159.3:ENST00000252085.4:exon1:c.C1868T:p.T623M	5q31.3	C3L-01971	.	.	.	.	.	.	.	.	.	11.18	D	D	D	D	.	D	H	T	D	0.442	T	T	D	0.357	0.706	0.849	.	.	T	T	T	D	D	2.856	23.100	0.998	D	N	0.506	5.082	0.342	3.968	0.986	0.677	0.588	0.576	0.601	.	5.060	4.130	-0.548	1.021	0.578	0.000	0.980	0.520	813	Cadherin-like	.	.	ID=COSV52744421;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),2(stomach)	PCDHGA12	363	0	834	72	0.0794701986754967	NA	TRUE
ENSG00000204227.5	.	BCM	GRCh38.p13	chr6	33209959	33209959	+	G	G	A	Missense_Mutation	SNP	ENST00000374656.5	exon4	c.G284A	p.R95Q	exonic	ENSG00000204227.5	.	nonsynonymous SNV	ENSG00000204227.5:ENST00000374656.5:exon4:c.G284A:p.R95Q	6p21.32	C3L-01971	.	.	.	.	.	.	.	.	.	13.19	D	D	D	P	D	D	M	T	D	0.796	T	T	D	0.403	0.341	0.793	1.680	T	D	D	T	D	.	4.320	29.700	1.000	D	D	0.772	8.258	0.714	8.018	1.000	0.707	0.702	0.554	0.714	.	4.230	4.230	9.588	1.166	0.665	1.000	0.998	0.995	712	.	.	.	ID=COSV63002527;OCCURENCE=1(stomach),1(endometrium)	RING1	307	0	556	148	0.210227272727273	TRUE	TRUE
ENSG00000213204.8	.	BCM	GRCh38.p13	chr6	87416780	87416780	+	G	G	A	Missense_Mutation	SNP	ENST00000369562.9	exon6	c.G584A	p.R195H	exonic	ENSG00000213204.8;ENSG00000272514.6	.	nonsynonymous SNV	ENSG00000272514.6:ENST00000369562.9:exon6:c.G584A:p.R195H,ENSG00000213204.8:ENST00000507897.5:exon6:c.G584A:p.R195H	6q15	C3L-01971	3.298e-05	0	0	0.0001	0	2.999e-05	0	6.061e-05	rs757635858	14.18	D	D	D	D	D	D	.	T	D	0.728	T	T	D	0.575	0.833	0.558	0.743	.	D	T	D	D	D	4.159	28.300	0.999	D	D	0.928	11.807	0.892	13.419	1.000	0.516	0.574	0.574	0.586	.	5.700	5.700	6.493	1.176	0.676	1.000	1.000	1.000	819	.	.	.	ID=COSV51532616;OCCURENCE=1(large_intestine),1(prostate)	AL049697.1	105	0	194	49	0.201646090534979	TRUE	TRUE
ENSG00000189241.8	.	BCM	GRCh38.p13	chr6	116278753	116278753	+	C	C	T	Missense_Mutation	SNP	ENST00000368608.4	exon1	c.G1078A	p.G360R	exonic	ENSG00000189241.8	.	nonsynonymous SNV	ENSG00000189241.8:ENST00000368608.4:exon1:c.G1078A:p.G360R	6q22.1	C3L-01971	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	N	D	M	T	D	0.620	T	T	D	0.303	0.682	0.542	1.617	T	T	T	T	D	D	4.150	28.200	0.999	D	N	0.676	6.797	0.586	6.055	1.000	0.543	0.686	0.686	0.639	.	4.320	4.320	4.231	0.959	0.520	0.996	0.971	0.997	566	.	.	.	.	TSPYL1	161	0	310	45	0.126760563380282	TRUE	TRUE
ENSG00000152818.18	.	BCM	GRCh38.p13	chr6	144485461	144485461	+	G	G	A	Missense_Mutation	SNP	ENST00000367545.7	exon27	c.G3764A	p.R1255Q	exonic	ENSG00000152818.18	.	nonsynonymous SNV	ENSG00000152818.18:ENST00000367545.7:exon27:c.G3764A:p.R1255Q	6q24.2	C3L-01971	4.118e-05	0.0002	0	0	0	2.997e-05	0	6.056e-05	rs752470080	5.19	D	.	D	B	D	N	L	T	N	0.129	T	T	T	0.067	0.404	0.321	0.277	T	T	T	T	T	D	3.347	24.300	0.999	D	N	0.231	3.445	0.261	3.497	0.722	0.732	0.725	0.744	0.714	.	5.120	4.250	3.133	1.176	0.676	0.999	0.907	0.990	894	.	.	.	ID=COSV104423030;OCCURENCE=1(large_intestine)	UTRN	178	0	290	24	0.0764331210191083	TRUE	NA
ENSG00000132436.11	.	BCM	GRCh38.p13	chr7	50445787	50445787	+	C	C	T	Missense_Mutation	SNP	ENST00000419119.1	exon2	c.G1501A	p.E501K	exonic	ENSG00000132436.11	.	nonsynonymous SNV	ENSG00000132436.11:ENST00000419119.1:exon2:c.G1501A:p.E501K	7p12.2	C3L-01971	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.919	D	D	D	0.959	0.970	0.996	0.172	D	D	D	D	D	D	4.110	27.800	0.999	D	D	1.132	19.049	1.050	22.319	1.000	0.722	0.699	0.710	0.735	.	6.170	6.170	7.905	1.026	0.599	1.000	1.000	0.994	768	ATPase,_AAA-type,_core;AAA+_ATPase_domain	.	.	ID=COSV63553302;OCCURENCE=1(large_intestine),3(endometrium)	FIGNL1	178	0	297	79	0.210106382978723	TRUE	TRUE
ENSG00000001626.16	.	BCM	GRCh38.p13	chr7	117611704	117611704	+	A	A	G	Missense_Mutation	SNP	ENST00000003084.11	exon20	c.A3263G	p.N1088S	exonic	ENSG00000001626.16	.	nonsynonymous SNV	ENSG00000001626.16:ENST00000003084.11:exon20:c.A3263G:p.N1088S	7q31.2	C3L-01971	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	L	D	N	0.387	T	T	D	0.279	0.682	0.984	0.005	T	T	T	T	D	D	1.427	15.260	0.961	D	D	0.222	3.403	0.346	3.997	0.999	0.554	0.574	0.618	0.564	.	5.690	5.690	3.790	0.321	-0.057	1.000	1.000	0.997	845	ABC_transporter_type_1,_transmembrane_domain	.	.	ID=COSV50054547;OCCURENCE=1(skin)	CFTR	345	0	706	143	0.168433451118963	TRUE	TRUE
ENSG00000135253.14	.	BCM	GRCh38.p13	chr7	128877528	128877528	+	C	C	T	Missense_Mutation	SNP	ENST00000613019.4	exon37	c.G4394A	p.R1465H	exonic	ENSG00000135253.14	.	nonsynonymous SNV	ENSG00000135253.14:ENST00000613019.4:exon37:c.G4394A:p.R1465H	7q32.1	C3L-01971	0.0001	0.0005	0	0	0	0	0	0.0001	rs368547608	5.7	.	D	.	.	.	.	.	.	.	0.473	.	.	.	.	.	0.362	.	T	T	D	D	.	D	3.703	25.400	0.868	D	.	.	.	.	.	1.000	0.162	0.187	0.129	0.059	0.974	5.280	5.280	1.064	1.022	0.596	0.489	1.000	0.994	571	Uncharacterised_domain,_cysteine-rich	.	.	.	KCP	183	0	431	40	0.0849256900212314	TRUE	NA
ENSG00000226660.2	.	BCM	GRCh38.p13	chr7	142301019	142301019	+	T	T	C	Missense_Mutation	SNP	ENST00000455382.2	exon1	c.T22C	p.W8R	exonic	ENSG00000226660.2	.	nonsynonymous SNV	ENSG00000226660.2:ENST00000455382.2:exon1:c.T22C:p.W8R	7q34	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRBV2	249	0	571	91	0.137462235649547	TRUE	TRUE
ENSG00000184661.14	.	BCM	GRCh38.p13	chr8	25507073	25507073	+	G	G	T	Nonsense_Mutation	SNP	ENST00000330560.8	exon15	c.G2407T	p.E803X	exonic	ENSG00000184661.14	.	stopgain	ENSG00000184661.14:ENST00000330560.8:exon15:c.G2407T:p.E803X	8p21.2	C3L-01971	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	D	.	.	.	0.112	.	.	.	.	.	.	.	.	.	D	D	.	.	7.433	38	0.986	N	N	0.463	4.759	0.171	3.046	1.000	0.732	0.725	0.688	0.728	.	5.600	3.690	1.811	1.176	0.676	0.762	0.256	0.628	925	.	.	.	.	CDCA2	184	1	293	45	0.133136094674556	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971178	21971178	+	C	C	-	Frame_Shift_Del	DEL	ENST00000304494.9	exon2	c.181delG	p.E61Sfs*85	exonic	ENSG00000147889.17	.	frameshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.181delG:p.E61Sfs*85	9p21.3	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	271	0	496	221	0.308228730822873	NA	TRUE
ENSG00000205143.3	.	BCM	GRCh38.p13	chr9	34623584	34623584	+	C	C	A	Missense_Mutation	SNP	ENST00000378909.3	exon4	c.G706T	p.G236C	exonic	ENSG00000205143.3	.	nonsynonymous SNV	ENSG00000205143.3:ENST00000378909.3:exon4:c.G706T:p.G236C	9p13.3	C3L-01971	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	N	M	T	N	0.171	T	T	D	0.029	0.329	0.238	0.292	T	T	T	T	T	T	1.287	14.290	0.996	D	N	-0.444	1.290	-0.565	1.099	0.999	0.598	0.563	0.596	0.639	.	4.780	0.709	0.188	0.129	0.526	0.260	0.015	0.071	269	.	.	.	.	ARID3C	43	0	119	32	0.211920529801325	TRUE	TRUE
ENSG00000136929.13	.	BCM	GRCh38.p13	chr9	97930076	97930076	+	G	G	A	Missense_Mutation	SNP	ENST00000616898.2	exon3	c.C1319T	p.A440V	exonic	ENSG00000136929.13	.	nonsynonymous SNV	ENSG00000136929.13:ENST00000616898.2:exon3:c.C1319T:p.A440V	9q22.33	C3L-01971	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	L	.	N	0.090	T	T	T	0.036	0.139	0.183	0.056	T	T	T	T	T	T	1.001	11.640	0.947	N	N	-0.781	0.683	-0.775	0.793	1.000	0.497	0.547	0.590	0.530	.	4.650	2.670	0.296	0.203	-0.244	0.000	0.954	0.985	605	.	.	.	.	HEMGN	186	0	385	38	0.0898345153664303	TRUE	TRUE
ENSG00000136861.18	.	BCM	GRCh38.p13	chr9	120536391	120536391	+	C	C	A	Missense_Mutation	SNP	ENST00000349780.9	exon7	c.G643T	p.V215F	exonic	ENSG00000136861.18	.	nonsynonymous SNV	ENSG00000136861.18:ENST00000349780.9:exon7:c.G643T:p.V215F	9q33.2	C3L-01971	.	.	.	.	.	.	.	.	.	5.20	D	T	D	P	N	N	M	T	N	0.404	T	T	T	0.086	0.111	0.563	0.225	T	T	T	T	D	D	2.940	23.300	0.994	N	N	0.273	3.643	0.248	3.427	1.000	0.707	0.725	0.725	0.714	.	5.390	5.390	2.196	1.026	0.599	0.394	0.174	0.827	951	.	.	.	.	CDK5RAP2	207	0	466	59	0.112380952380952	TRUE	TRUE
ENSG00000197694.18	.	BCM	GRCh38.p13	chr9	128577223	128577223	+	C	C	T	Missense_Mutation	SNP	ENST00000372731.8	exon7	c.C880T	p.L294F	exonic	ENSG00000197694.18	.	nonsynonymous SNV	ENSG00000197694.18:ENST00000372731.8:exon7:c.C880T:p.L294F	9q34.11	C3L-01971	.	.	.	.	.	.	.	.	.	10.20	T	T	D	D	D	D	L	T	N	0.755	T	T	D	0.190	0.632	0.525	1.837	D	T	T	T	D	D	3.045	23.500	0.999	D	D	0.702	7.140	0.726	8.277	1.000	0.707	0.725	0.725	0.711	.	6.170	6.170	3.891	1.026	0.599	1.000	1.000	0.996	0	.	.	.	.	SPTAN1	473	0	886	188	0.175046554934823	TRUE	TRUE
ENSG00000180720.7	.	BCM	GRCh38.p13	chr11	46385280	46385280	+	G	G	C	Missense_Mutation	SNP	ENST00000433765.3	exon1	c.C1278G	p.C426W	exonic	ENSG00000180720.7	.	nonsynonymous SNV	ENSG00000180720.7:ENST00000433765.3:exon1:c.C1278G:p.C426W	11p11.2	C3L-01971	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	.	D	M	T	D	0.939	D	D	D	0.719	0.747	0.896	2.271	D	D	D	D	D	D	4.014	27.100	0.994	D	D	0.579	5.713	0.517	5.321	1.000	0.660	0.590	0.696	0.605	.	4.580	4.580	0.876	1.164	0.660	1.000	1.000	0.999	31	GPCR,_rhodopsin-like,_7TM	.	.	.	CHRM4	155	0	358	79	0.180778032036613	TRUE	TRUE
ENSG00000149136.9	.	BCM	GRCh38.p13	chr11	57332713	57332713	+	C	C	T	Missense_Mutation	SNP	ENST00000278412.7	exon6	c.G680A	p.G227D	exonic	ENSG00000149136.9	.	nonsynonymous SNV	ENSG00000149136.9:ENST00000278412.7:exon6:c.G680A:p.G227D	11q12.1	C3L-01971	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.886	D	D	D	0.711	0.932	0.771	2.726	D	D	D	D	D	D	3.867	26.200	0.999	D	D	0.974	13.124	0.913	14.338	1.000	0.719	0.723	0.725	0.714	.	5.800	5.800	7.521	1.026	0.599	1.000	0.954	0.964	442	.	.	.	ID=COSV53479305;OCCURENCE=1(prostate)	SSRP1	124	1	286	53	0.156342182890855	TRUE	TRUE
ENSG00000149311.18	.	BCM	GRCh38.p13	chr11	108229309	108229309	+	A	A	G	Missense_Mutation	SNP	ENST00000278616.8	exon4	c.A317G	p.K106R	exonic	ENSG00000149311.18	.	nonsynonymous SNV	ENSG00000149311.18:ENST00000278616.8:exon4:c.A317G:p.K106R	11q22.3	C3L-01971	.	.	.	.	.	.	.	.	rs878853501	2.20	T	T	B	B	N	N	N	T	N	0.299	T	T	T	0.082	0.309	0.748	0.106	T	T	T	T	D	T	1.853	18.120	0.838	D	N	-0.395	1.394	-0.153	1.904	1.000	0.732	0.744	0.651	0.684	.	5.850	3.570	5.673	1.288	0.756	1.000	1.000	0.998	125	Telomere-length_maintenance_and_DNA_damage_repair	.	.	.	ATM	232	0	434	85	0.163776493256262	TRUE	NA
ENSG00000149294.16	.	BCM	GRCh38.p13	chr11	113235153	113235153	+	C	C	T	Missense_Mutation	SNP	ENST00000316851.11	exon14	c.C1814T	p.T605M	exonic	ENSG00000149294.16	.	nonsynonymous SNV	ENSG00000149294.16:ENST00000316851.11:exon14:c.C1814T:p.T605M	11q23.2	C3L-01971	8.861e-06	0	0	0	0	1.605e-05	0	0	rs782353037	12.16	.	D	D	D	U	D	.	.	.	0.857	T	T	D	0.487	0.184	0.488	.	T	D	D	D	D	D	4.117	27.900	0.999	D	D	0.804	8.852	0.819	10.706	1.000	0.554	0.563	0.602	0.564	.	5.840	5.840	7.715	1.026	0.549	1.000	0.993	0.988	656	Fibronectin_type_III	.	.	ID=COSV57517108;OCCURENCE=1(cervix),4(large_intestine)	NCAM1	137	0	366	74	0.168181818181818	TRUE	TRUE
ENSG00000149428.19	.	BCM	GRCh38.p13	chr11	119048802	119048802	+	G	G	A	Missense_Mutation	SNP	ENST00000617285.5	exon18	c.C2077T	p.R693W	exonic	ENSG00000149428.19	.	nonsynonymous SNV	ENSG00000149428.19:ENST00000617285.5:exon18:c.C2077T:p.R693W	11q23.3	C3L-01971	8.255e-06	0	0	0	0	1.5e-05	0	0	rs782191000	6.16	.	D	P	P	D	D	L	.	.	0.263	T	T	T	0.183	0.477	0.310	.	T	T	T	T	D	.	3.995	26.900	0.999	D	D	0.425	4.502	0.441	4.661	1.000	0.707	0.696	0.702	0.714	.	5.370	5.370	4.285	1.176	0.676	1.000	0.990	0.753	243	.	.	.	.	HYOU1	98	0	278	55	0.165165165165165	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-01971	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	245	0	412	210	0.337620578778135	TRUE	TRUE
ENSG00000139718.10	.	BCM	GRCh38.p13	chr12	121825313	121825314	+	AG	AG	-	Frame_Shift_Del	DEL	ENST00000604567.5	exon13	c.5284_5285del	p.R1762Ifs*11	exonic	ENSG00000139718.10	.	frameshift deletion	ENSG00000139718.10:ENST00000604567.5:exon13:c.5284_5285del:p.R1762Ifs*11	12q24.31	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SETD1B	178	0	351	76	0.177985948477752	TRUE	TRUE
ENSG00000185950.9	.	BCM	GRCh38.p13	chr13	109783310	109783310	+	C	C	T	Missense_Mutation	SNP	ENST00000375856.5	exon1	c.G2744A	p.S915N	exonic	ENSG00000185950.9	.	nonsynonymous SNV	ENSG00000185950.9:ENST00000375856.5:exon1:c.G2744A:p.S915N	13q34	C3L-01971	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	U	D	M	T	N	0.447	D	D	D	0.290	0.274	0.869	.	D	D	T	T	D	D	3.676	25.300	0.997	D	D	0.740	7.714	0.682	7.430	1.000	0.696	0.588	0.692	0.605	.	4.420	4.420	5.687	0.950	0.520	1.000	0.998	0.986	968	.	.	.	.	IRS2	61	0	156	51	0.246376811594203	TRUE	TRUE
ENSG00000213903.9	.	BCM	GRCh38.p13	chr14	24316130	24316130	+	C	C	T	Missense_Mutation	SNP	ENST00000345363.8	exon2	c.C479T	p.P160L	exonic	ENSG00000213903.9	.	nonsynonymous SNV	ENSG00000213903.9:ENST00000345363.8:exon2:c.C479T:p.P160L	14q12	C3L-01971	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	N	T	N	0.178	T	T	T	0.168	0.496	0.384	0.884	T	T	T	T	T	.	-1.716	0.001	0.728	N	N	-1.861	0.018	-2.007	0.013	1.000	0.741	0.644	0.000	0.722	.	5.330	-10.700	-11.165	-0.097	-1.657	0.000	0.000	0.001	856	GPCR,_rhodopsin-like,_7TM	.	.	.	LTB4R	179	0	516	98	0.159609120521173	TRUE	TRUE
ENSG00000157766.18	.	BCM	GRCh38.p13	chr15	88838876	88838876	+	G	G	A	Missense_Mutation	SNP	ENST00000439576.7	exon3	c.G284A	p.R95Q	exonic	ENSG00000157766.18	.	nonsynonymous SNV	ENSG00000157766.18:ENST00000439576.7:exon3:c.G284A:p.R95Q	15q26.1	C3L-01971	1.656e-05	0	0	0	0	2.998e-05	0	0	rs539804190	8.19	D	D	P	B	.	D	L	T	D	0.344	T	T	T	0.174	0.619	0.159	0.228	T	D	T	T	D	D	2.850	23.100	0.999	D	N	0.229	3.432	0.264	3.515	1.000	0.526	0.590	0.506	0.584	.	5.360	4.450	3.285	1.176	0.618	1.000	0.463	0.885	966	Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV61360848;OCCURENCE=1(lung)	ACAN	381	0	724	95	0.115995115995116	TRUE	NA
ENSG00000197562.10	.	BCM	GRCh38.p13	chr16	627597	627597	+	C	C	G	Missense_Mutation	SNP	ENST00000248139.8	exon6	c.C821G	p.S274W	exonic	ENSG00000197562.10	.	nonsynonymous SNV	ENSG00000197562.10:ENST00000248139.8:exon6:c.C821G:p.S274W	16p13.3	C3L-01971	.	.	.	.	.	.	.	.	.	9.20	D	D	P	B	D	D	L	T	N	0.514	T	T	D	0.224	0.285	0.862	1.866	T	T	T	T	D	D	3.247	24.000	0.987	D	D	0.350	4.050	0.400	4.362	1.000	0.660	0.694	0.723	0.662	.	4.850	4.850	6.063	1.026	0.599	1.000	0.828	0.929	649	.	.	.	.	RAB40C	63	0	117	30	0.204081632653061	TRUE	TRUE
ENSG00000103351.13	.	BCM	GRCh38.p13	chr16	3504755	3504755	+	C	C	T	Nonsense_Mutation	SNP	ENST00000576634.6	exon2	c.C58T	p.R20X	exonic	ENSG00000103351.13	.	stopgain	ENSG00000103351.13:ENST00000576634.6:exon2:c.C58T:p.R20X	16p13.3	C3L-01971	8.239e-06	0	0	0.0001	0	0	0	0	rs759248659	5.6	.	.	.	.	D	D	.	.	.	0.474	.	.	.	.	.	.	.	.	.	D	D	.	.	7.708	39	0.998	D	N	0.776	8.322	0.635	6.693	1.000	0.745	0.634	0.659	0.762	.	5.340	4.390	5.648	0.963	0.526	1.000	0.992	0.978	707	.	.	.	ID=COSV58892567;OCCURENCE=1(central_nervous_system)	CLUAP1	192	0	322	43	0.117808219178082	TRUE	TRUE
ENSG00000183549.10	.	BCM	GRCh38.p13	chr16	20423981	20423981	+	C	C	A	Missense_Mutation	SNP	ENST00000331849.8	exon6	c.C833A	p.A278E	exonic	ENSG00000183549.10	.	nonsynonymous SNV	ENSG00000183549.10:ENST00000331849.8:exon6:c.C833A:p.A278E	16p12.3	C3L-01971	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	H	T	N	0.603	T	T	T	0.420	0.824	0.784	0.605	T	T	D	T	D	D	3.232	23.900	0.995	N	D	0.526	5.246	0.391	4.298	1.000	0.554	0.547	0.618	0.564	.	4.560	4.560	2.121	1.026	0.599	0.040	1.000	0.996	809	AMP-dependent_synthetase/ligase	.	.	.	ACSM5	259	0	577	94	0.140089418777943	NA	TRUE
ENSG00000006116.4	.	BCM	GRCh38.p13	chr16	24361649	24361649	+	G	G	A	Missense_Mutation	SNP	ENST00000005284.4	exon4	c.G734A	p.R245Q	exonic	ENSG00000006116.4	.	nonsynonymous SNV	ENSG00000006116.4:ENST00000005284.4:exon4:c.G734A:p.R245Q	16p12.1	C3L-01971	1.648e-05	0	0	0	0	2.999e-05	0	0	rs746004181	10.20	D	T	D	P	D	D	M	T	N	0.355	T	T	D	0.235	0.300	0.448	1.962	T	T	T	T	D	D	3.738	25.600	1.000	D	D	0.685	6.908	0.679	7.376	0.999	0.554	0.588	0.618	0.564	.	4.950	4.950	6.470	1.176	0.674	1.000	1.000	0.999	917	.	.	.	ID=COSV50065372;OCCURENCE=1(central_nervous_system),1(skin),1(prostate)	CACNG3	123	0	232	59	0.202749140893471	TRUE	TRUE
ENSG00000168676.11	.	BCM	GRCh38.p13	chr16	67290959	67290959	+	C	C	T	Missense_Mutation	SNP	ENST00000304372.6	exon15	c.G2593A	p.V865M	exonic	ENSG00000168676.11	.	nonsynonymous SNV	ENSG00000168676.11:ENST00000304372.6:exon15:c.G2593A:p.V865M	16q22.1	C3L-01971	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	L	T	N	0.776	T	T	D	0.270	0.158	0.861	0.956	T	T	D	D	D	D	3.661	25.300	0.999	D	D	0.599	5.918	0.637	6.725	1.000	0.554	0.588	0.547	0.568	.	5.670	5.670	4.713	1.026	0.599	1.000	1.000	0.997	23	.	.	.	.	KCTD19	132	0	312	66	0.174603174603175	TRUE	TRUE
ENSG00000140873.16	.	BCM	GRCh38.p13	chr16	77353875	77353875	+	G	G	A	Missense_Mutation	SNP	ENST00000282849.10	exon10	c.C1472T	p.A491V	exonic	ENSG00000140873.16	.	nonsynonymous SNV	ENSG00000140873.16:ENST00000282849.10:exon10:c.C1472T:p.A491V	16q23.1	C3L-01971	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	D	D	L	T	D	0.855	T	T	T	0.367	0.856	0.444	.	T	T	T	T	D	D	3.572	24.900	0.998	D	D	0.389	4.275	0.502	5.178	1.000	0.563	0.574	0.547	0.636	.	5.220	5.220	9.488	1.167	0.676	1.000	0.671	0.775	791	Peptidase_M12B,_ADAM/reprolysin	.	.	ID=COSV51423374;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	ADAMTS18	438	0	712	143	0.167251461988304	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673823	7673823	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G797A	p.G266E	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G797A:p.G266E	17p13.1	C3L-01971	.	.	.	.	.	.	.	.	rs193920774	19.20	D	D	D	D	D	D	M	D	D	0.974	D	D	D	0.973	0.928	0.991	0.434	T	D	D	D	D	D	4.155	28.200	0.998	D	D	0.885	10.673	0.802	10.174	1.000	0.722	0.702	0.725	0.735	.	5.130	5.130	7.905	1.022	0.596	1.000	0.975	0.969	432	p53,_DNA-binding_domain	.	.	ID=COSV52664019;OCCURENCE=22(breast),3(liver),1(genital_tract),10(oesophagus),1(cervix),12(large_intestine),3(central_nervous_system),5(biliary_tract),1(vulva),4(ovary),1(bone),1(NS),5(stomach),8(haematopoietic_and_lymphoid_tissue),2(kidney),7(urinary_tract),8(pancreas),4(skin),2(prostate),11(lung),1(thyroid),9(upper_aerodigestive_tract),1(small_intestine),2(endometrium)	TP53	457	0	724	193	0.210468920392585	TRUE	TRUE
ENSG00000141741.12	.	BCM	GRCh38.p13	chr17	39730221	39730221	+	C	C	T	Missense_Mutation	SNP	ENST00000394231.8	exon2	c.G160A	p.E54K	exonic	ENSG00000141741.12	.	nonsynonymous SNV	ENSG00000141741.12:ENST00000394231.8:exon2:c.G160A:p.E54K	17q12	C3L-01971	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	L	T	N	0.372	T	T	T	0.031	0.427	0.134	0.435	D	T	T	T	D	T	2.752	22.900	0.985	D	N	-0.254	1.730	-0.094	2.063	1.000	0.442	0.522	0.522	0.562	.	5.050	2.960	1.872	1.016	0.537	1.000	0.996	0.991	583	.	.	.	.	MIEN1	128	1	376	38	0.0917874396135266	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51048711	51048712	+	AT	AT	-	Frame_Shift_Del	DEL	ENST00000342988.8	exon3	c.275_276del	p.H92Rfs*11	exonic	ENSG00000141646.14	.	frameshift deletion	ENSG00000141646.14:ENST00000342988.8:exon3:c.275_276del:p.H92Rfs*11	18q21.2	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMAD4	418	0	609	137	0.183646112600536	TRUE	TRUE
ENSG00000172000.7	.	BCM	GRCh38.p13	chr19	2877334	2877334	+	T	T	C	Missense_Mutation	SNP	ENST00000307635.3	exon4	c.T376C	p.F126L	exonic	ENSG00000172000.7	.	nonsynonymous SNV	ENSG00000172000.7:ENST00000307635.3:exon4:c.T376C:p.F126L	19p13.3	C3L-01971	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	.	N	M	T	D	0.108	T	T	T	0.035	0.377	0.076	0.072	T	T	T	T	T	T	0.507	6.580	0.830	N	N	-0.941	0.470	-1.091	0.385	0.000	0.487	0.574	0.547	0.564	.	2.270	-0.059	-0.246	-0.090	0.468	0.000	0.002	0.015	994	.	.	.	.	ZNF556	132	0	228	54	0.191489361702128	TRUE	TRUE
ENSG00000089847.12	.	BCM	GRCh38.p13	chr19	4219678	4219678	+	C	C	T	Missense_Mutation	SNP	ENST00000600132.5	exon19	c.C3091T	p.R1031W	exonic	ENSG00000089847.12	.	nonsynonymous SNV	ENSG00000089847.12:ENST00000600132.5:exon19:c.C3091T:p.R1031W	19p13.3	C3L-01971	3.344e-05	0.0003	0	0	0	0	0	6.089e-05	rs771211944	11.19	D	D	D	D	.	N	M	T	D	0.674	T	T	D	0.129	.	0.355	0.925	D	T	T	T	D	D	3.734	25.500	0.999	D	N	0.176	3.197	0.104	2.751	0.000	0.706	0.634	0.710	0.568	.	3.790	2.620	2.771	1.021	0.549	0.996	0.005	0.082	928	.	.	.	ID=COSV53667982;OCCURENCE=1(oesophagus)	ANKRD24	168	0	531	43	0.0749128919860627	TRUE	TRUE
ENSG00000129353.15	.	BCM	GRCh38.p13	chr19	10631065	10631065	+	C	C	G	Missense_Mutation	SNP	ENST00000335757.10	exon5	c.C254G	p.P85R	exonic	ENSG00000129353.15	.	nonsynonymous SNV	ENSG00000129353.15:ENST00000335757.10:exon5:c.C254G:p.P85R	19p13.2	C3L-01971	.	.	.	.	.	.	.	.	.	12.20	D	D	P	P	D	D	M	T	D	0.596	T	T	D	0.276	0.529	0.625	0.658	T	T	D	T	D	D	3.385	24.400	0.995	D	D	0.543	5.384	0.521	5.358	1.000	0.707	0.725	0.644	0.714	.	4.690	4.690	5.566	1.011	0.582	0.977	0.677	0.975	814	.	.	.	.	SLC44A2	67	0	148	31	0.173184357541899	TRUE	TRUE
ENSG00000161270.19	.	BCM	GRCh38.p13	chr19	35845685	35845685	+	C	C	A	Missense_Mutation	SNP	ENST00000378910.9	exon13	c.G1741T	p.D581Y	exonic	ENSG00000161270.19	.	nonsynonymous SNV	ENSG00000161270.19:ENST00000378910.9:exon13:c.G1741T:p.D581Y	19q13.12	C3L-01971	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	D	D	L	T	N	0.593	T	T	D	0.358	0.497	0.726	1.807	T	T	T	T	D	T	3.685	25.300	0.968	D	N	-0.442	1.294	-0.261	1.646	1.000	0.598	0.563	0.666	0.639	.	5.140	5.140	1.267	0.868	0.511	1.000	0.998	0.784	824	Immunoglobulin_subtype_2;CD80-like,_immunoglobulin_C2-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	NPHS1	164	0	344	30	0.0802139037433155	TRUE	TRUE
ENSG00000170949.17	.	BCM	GRCh38.p13	chr19	53068768	53068768	+	C	C	G	Missense_Mutation	SNP	ENST00000429604.5	exon7	c.G1766C	p.G589A	exonic	ENSG00000170949.17	.	nonsynonymous SNV	ENSG00000170949.17:ENST00000429604.5:exon7:c.G1766C:p.G589A	19q13.41	C3L-01971	.	.	.	.	.	.	.	.	.	6.19	D	D	D	D	.	N	L	T	D	0.198	T	T	T	0.111	0.461	0.375	0.841	T	T	T	T	D	T	2.832	23.100	0.996	N	N	0.002	2.518	-0.215	1.751	0.057	0.707	0.725	0.702	0.636	.	2.230	1.160	1.805	0.632	0.505	0.007	0.993	0.724	994	Zinc_finger_C2H2-type	.	.	.	ZNF160	128	0	253	64	0.201892744479495	TRUE	TRUE
ENSG00000083814.13	.	BCM	GRCh38.p13	chr19	57723241	57723241	+	C	C	A	Nonsense_Mutation	SNP	ENST00000317398.10	exon2	c.G238T	p.E80X	exonic	ENSG00000083814.13	.	stopgain	ENSG00000083814.13:ENST00000317398.10:exon2:c.G238T:p.E80X	19q13.43	C3L-01971	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	A	.	.	.	0.070	.	.	.	.	.	.	.	.	.	D	D	.	.	5.173	33	0.994	N	N	0.207	3.335	-0.197	1.793	0.000	0.672	0.702	0.651	0.492	.	1.250	0.119	0.765	-0.053	0.549	0.004	0.018	0.999	970	Krueppel-associated_box	.	.	.	ZNF671	57	0	97	27	0.217741935483871	TRUE	TRUE
ENSG00000124203.6	.	BCM	GRCh38.p13	chr20	59194719	59194719	+	A	A	G	Missense_Mutation	SNP	ENST00000637017.1	exon4	c.A3700G	p.T1234A	exonic	ENSG00000124203.6	.	nonsynonymous SNV	ENSG00000124203.6:ENST00000637017.1:exon4:c.A3700G:p.T1234A	20q13.32	C3L-01971	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.069	T	T	T	0.035	0.098	0.055	0.208	T	T	T	T	T	T	0.670	8.176	0.791	N	N	-0.922	0.493	-0.988	0.503	0.000	0.554	0.588	0.547	0.564	.	3.550	1.290	0.698	1.290	0.731	0.000	0.011	0.012	993	.	.	.	.	ZNF831	40	0	74	22	0.229166666666667	TRUE	TRUE
ENSG00000142207.7	.	BCM	GRCh38.p13	chr21	32363160	32363160	+	C	C	A	Missense_Mutation	SNP	ENST00000382751.4	exon11	c.G1505T	p.S502I	exonic	ENSG00000142207.7	.	nonsynonymous SNV	ENSG00000142207.7:ENST00000382751.4:exon11:c.G1505T:p.S502I	21q22.11	C3L-01971	.	.	.	.	.	.	.	.	.	9.20	T	D	D	P	D	D	M	T	N	0.591	T	T	T	0.202	0.391	0.486	.	T	T	T	T	D	D	3.698	25.400	0.996	D	D	0.533	5.300	0.521	5.353	1.000	0.707	0.654	0.725	0.714	.	5.380	4.470	7.169	1.026	0.599	1.000	1.000	0.968	921	.	.	.	.	URB1	72	1	141	42	0.229508196721311	TRUE	TRUE
ENSG00000258992.7	.	BCM	GRCh38.p13	chrY	9467440	9467440	+	G	G	A	Missense_Mutation	SNP	ENST00000451548.6	exon1	c.G440A	p.R147H	exonic	ENSG00000258992.7	.	nonsynonymous SNV	ENSG00000258992.7:ENST00000451548.6:exon1:c.G440A:p.R147H	Yp11.2	C3L-01971	.	.	.	.	.	.	.	.	.	2.16	T	T	P	B	.	.	L	T	D	0.083	T	T	D	0.041	.	0.193	.	.	T	T	T	T	T	0.493	6.432	0.977	N	.	.	.	.	.	0.000	.	.	.	.	.	.	.	-0.053	0.225	0.221	0.669	0.017	0.017	.	.	.	.	.	TSPY1	187	0	326	27	0.0764872521246459	NA	TRUE
ENSG00000130779.20	.	BCM	GRCh38.p13	chr12	122328260	122328260	+	C	C	A	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000130779.20	ENST00000620786.4:exon16:c.3033+1G>T	.	.	12q24.31	C3L-01971	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.049	33	0.991	D	.	0.982	13.367	0.791	9.852	1.000	0.156	0.156	0.126	0.235	0.960	5.250	5.250	4.037	1.026	0.599	1.000	0.953	0.562	653	.	.	.	.	CLIP1	87	0	231	30	0.114942528735632	TRUE	TRUE
ENSG00000163485.17	.	BCM	GRCh38.p13	chr1	203129136	203129136	+	C	C	T	Silent	SNP	ENST00000337894.9	exon3	c.C295T	p.L99L	exonic	ENSG00000163485.17	.	synonymous SNV	ENSG00000163485.17:ENST00000337894.9:exon3:c.C295T:p.L99L	1q32.1	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADORA1	91	0	216	23	0.096234309623431	TRUE	TRUE
ENSG00000196878.15	.	BCM	GRCh38.p13	chr1	209634624	209634624	+	G	G	A	Silent	SNP	ENST00000356082.9	exon6	c.C387T	p.A129A	exonic	ENSG00000196878.15	.	synonymous SNV	ENSG00000196878.15:ENST00000356082.9:exon6:c.C387T:p.A129A	1q32.2	C3L-01971	7.06e-05	0.0009	0	0	0	0	0	0	rs374988953	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61919934;OCCURENCE=1(endometrium)	LAMB3	273	0	450	112	0.199288256227758	TRUE	TRUE
ENSG00000115902.11	.	BCM	GRCh38.p13	chr2	65021113	65021113	+	C	C	G	Silent	SNP	ENST00000234256.4	exon8	c.C1566G	p.A522A	exonic	ENSG00000115902.11	.	synonymous SNV	ENSG00000115902.11:ENST00000234256.4:exon8:c.C1566G:p.A522A	2p14	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC1A4	158	0	241	27	0.100746268656716	TRUE	TRUE
ENSG00000168356.12	.	BCM	GRCh38.p13	chr3	38897154	38897154	+	G	G	T	Silent	SNP	ENST00000668754.1	exon21	c.C2094A	p.V698V	exonic	ENSG00000168356.12	.	synonymous SNV	ENSG00000168356.12:ENST00000668754.1:exon21:c.C2094A:p.V698V	3p22.2	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCN11A	160	1	277	64	0.187683284457478	TRUE	TRUE
ENSG00000164050.13	.	BCM	GRCh38.p13	chr3	48419736	48419736	+	G	G	A	Silent	SNP	ENST00000296440.11	exon11	c.C2550T	p.P850P	exonic	ENSG00000164050.13	.	synonymous SNV	ENSG00000164050.13:ENST00000296440.11:exon11:c.C2550T:p.P850P	3p21.31	C3L-01971	3.384e-05	0.0002	0	0	0	4.081e-05	0	0	rs774347842	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLXNB1	107	0	319	33	0.09375	TRUE	NA
ENSG00000133401.16	.	BCM	GRCh38.p13	chr5	32090663	32090663	+	C	C	T	Silent	SNP	ENST00000438447.2	exon20	c.C7215T	p.S2405S	exonic	ENSG00000133401.16	.	synonymous SNV	ENSG00000133401.16:ENST00000438447.2:exon20:c.C7215T:p.S2405S	5p13.3	C3L-01971	3.297e-05	0	0.0002	0	0	1.5e-05	0.0011	0	rs768918693	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56876735;OCCURENCE=1(large_intestine)	PDZD2	105	0	278	63	0.18475073313783	TRUE	TRUE
ENSG00000145794.17	.	BCM	GRCh38.p13	chr5	127438515	127438515	+	C	C	T	Silent	SNP	ENST00000503335.7	exon17	c.C2181T	p.Y727Y	exonic	ENSG00000145794.17	.	synonymous SNV	ENSG00000145794.17:ENST00000503335.7:exon17:c.C2181T:p.Y727Y	5q23.2	C3L-01971	1.649e-05	0	0	0	0	3e-05	0	0	rs757670476	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV57244980;OCCURENCE=1(oesophagus)	MEGF10	184	0	338	29	0.0790190735694823	TRUE	TRUE
ENSG00000204767.4	.	BCM	GRCh38.p13	chr5	169883734	169883734	+	G	G	A	Silent	SNP	ENST00000377365.4	exon2	c.C165T	p.D55D	exonic	ENSG00000204767.4	.	synonymous SNV	ENSG00000204767.4:ENST00000377365.4:exon2:c.C165T:p.D55D	5q35.1	C3L-01971	.	.	.	.	.	.	.	.	rs748170159	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INSYN2B	86	1	195	35	0.152173913043478	TRUE	NA
ENSG00000113749.7	.	BCM	GRCh38.p13	chr5	175683989	175683989	+	C	C	T	Silent	SNP	ENST00000231683.3	exon1	c.C756T	p.T252T	exonic	ENSG00000113749.7	.	synonymous SNV	ENSG00000113749.7:ENST00000231683.3:exon1:c.C756T:p.T252T	5q35.2	C3L-01971	0.0002	0	0	0.0003	0	0.0001	0	0.0007	rs199745107	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99199547;OCCURENCE=1(endometrium)	HRH2	364	0	734	143	0.163055872291904	TRUE	NA
ENSG00000157593.19	.	BCM	GRCh38.p13	chr6	44256429	44256429	+	C	C	T	Silent	SNP	ENST00000393812.4	exon3	c.G273A	p.E91E	exonic	ENSG00000157593.19	.	synonymous SNV	ENSG00000157593.19:ENST00000393812.4:exon3:c.G273A:p.E91E	6p21.1	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC35B2	206	0	358	115	0.243128964059197	TRUE	TRUE
ENSG00000196876.18	.	BCM	GRCh38.p13	chr12	51706619	51706619	+	G	G	A	Silent	SNP	ENST00000354534.11	exon11	c.G1539A	p.E513E	exonic	ENSG00000196876.18	.	synonymous SNV	ENSG00000196876.18:ENST00000354534.11:exon11:c.G1539A:p.E513E	12q13.13	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCN8A	92	0	149	66	0.306976744186047	TRUE	TRUE
ENSG00000167780.12	.	BCM	GRCh38.p13	chr12	53123164	53123164	+	C	C	T	Silent	SNP	ENST00000301466.8	exon13	c.C1320T	p.F440F	exonic	ENSG00000167780.12	.	synonymous SNV	ENSG00000167780.12:ENST00000301466.8:exon13:c.C1320T:p.F440F	12q13.13	C3L-01971	.	.	.	.	.	.	.	.	rs201335480	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56859558;OCCURENCE=1(skin),1(upper_aerodigestive_tract)	SOAT2	207	0	383	185	0.325704225352113	TRUE	TRUE
ENSG00000188596.11	.	BCM	GRCh38.p13	chr12	96623802	96623802	+	A	A	G	Silent	SNP	ENST00000524981.9	exon28	c.A3807G	p.P1269P	exonic	ENSG00000188596.11	.	synonymous SNV	ENSG00000188596.11:ENST00000524981.9:exon28:c.A3807G:p.P1269P	12q23.1	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CFAP54	136	0	291	45	0.133928571428571	TRUE	TRUE
ENSG00000100505.13	.	BCM	GRCh38.p13	chr14	50981871	50981871	+	G	G	A	Silent	SNP	ENST00000298355.7	exon8	c.C1836T	p.D612D	exonic	ENSG00000100505.13	.	synonymous SNV	ENSG00000100505.13:ENST00000298355.7:exon8:c.C1836T:p.D612D	14q22.1	C3L-01971	8.236e-06	9.61e-05	0	0	0	0	0	0	rs757270399	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53624076;OCCURENCE=1(stomach),1(endometrium)	TRIM9	283	0	636	60	0.0862068965517241	TRUE	TRUE
ENSG00000054690.14	.	BCM	GRCh38.p13	chr14	67562735	67562735	+	T	T	G	Silent	SNP	ENST00000329153.10	exon7	c.T1104G	p.A368A	exonic	ENSG00000054690.14	.	synonymous SNV	ENSG00000054690.14:ENST00000329153.10:exon7:c.T1104G:p.A368A	14q24.1	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEKHH1	257	0	521	114	0.179527559055118	TRUE	TRUE
ENSG00000211972.2	.	BCM	GRCh38.p13	chr14	106675299	106675299	+	C	C	T	Silent	SNP	ENST00000390632.2	exon2	c.G66A	p.Q22Q	exonic	ENSG00000211972.2	.	synonymous SNV	ENSG00000211972.2:ENST00000390632.2:exon2:c.G66A:p.Q22Q	14q32.33	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGHV3-66	247	1	511	92	0.15257048092869	NA	TRUE
ENSG00000082641.16	.	BCM	GRCh38.p13	chr17	48059590	48059590	+	C	C	T	Silent	SNP	ENST00000362042.8	exon6	c.C2268T	p.A756A	exonic	ENSG00000082641.16	.	synonymous SNV	ENSG00000082641.16:ENST00000362042.8:exon6:c.C2268T:p.A756A	17q21.32	C3L-01971	0.0093	0.0008	0.0008	0	0.0706	0.0088	0.0146	0.0008	rs143499120	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NFE2L1	39	0	89	9	0.0918367346938776	TRUE	NA
ENSG00000100228.12	.	BCM	GRCh38.p13	chr22	23145548	23145548	+	G	G	T	Silent	SNP	ENST00000263116.6	exon1	c.G183T	p.S61S	exonic	ENSG00000100228.12	.	synonymous SNV	ENSG00000100228.12:ENST00000263116.6:exon1:c.G183T:p.S61S	22q11.23	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAB36	78	1	130	44	0.252873563218391	TRUE	TRUE
ENSG00000100241.21	.	BCM	GRCh38.p13	chr22	50464849	50464849	+	G	G	A	Silent	SNP	ENST00000348911.10	exon13	c.C1404T	p.V468V	exonic	ENSG00000100241.21	.	synonymous SNV	ENSG00000100241.21:ENST00000348911.10:exon13:c.C1404T:p.V468V	22q13.33	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SBF1	151	0	382	35	0.0839328537170264	TRUE	TRUE
ENSG00000185960.14	.	BCM	GRCh38.p13	chrX	634820	634820	+	C	C	T	Silent	SNP	ENST00000381578.6	exon3	c.C480T	p.R160R	exonic	ENSG00000185960.14	.	synonymous SNV	ENSG00000185960.14:ENST00000381578.6:exon3:c.C480T:p.R160R	Xp22.33	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SHOX	179	1	337	92	0.214452214452214	TRUE	TRUE
ENSG00000174175.17	.	BCM	GRCh38.p13	chr1	169630076	169630076	+	T	T	C	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000174175.17	ENST00000263686.11:c.-2A>G	.	.	1q24.2	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SELP	163	0	335	30	0.0821917808219178	TRUE	NA
ENSG00000163531.15	.	BCM	GRCh38.p13	chr1	205016621	205016621	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000163531.15	ENST00000339876.10:c.*82G>A	.	.	1q32.1	C3L-01971	0.0002	0.0005	0	0	0	0.0003	0	9.747e-05	rs541890830	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58370252;OCCURENCE=1(skin)	NFASC	197	0	363	88	0.195121951219512	TRUE	NA
ENSG00000118960.13	.	BCM	GRCh38.p13	chr2	20640916	20640916	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000118960.13	.	.	.	2p24.1	C3L-01971	8.603e-06	0	0	0	0	0	0	7.322e-05	rs771649844	1.14	D	.	B	B	.	N	.	.	N	0.060	T	T	T	0.055	0.122	0.124	.	.	.	T	T	T	T	-0.972	0.009	0.290	N	N	-1.784	0.025	-1.962	0.016	1.000	0.554	0.588	0.576	0.509	.	3.710	-7.420	-4.833	-0.847	-0.876	0.000	0.000	0.000	850	.	.	.	ID=COSV58313647;OCCURENCE=1(large_intestine),1(central_nervous_system)	HS1BP3	73	0	127	34	0.211180124223602	TRUE	NA
ENSG00000047849.21	.	BCM	GRCh38.p13	chr3	47911566	47911568	+	AAG	AAG	-	Intron	DEL	NA	NA	NA	NA	intronic	ENSG00000047849.21	.	.	.	3p21.31	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP4	154	0	269	51	0.159375	TRUE	NA
ENSG00000181195.11	.	BCM	GRCh38.p13	chr8	56444019	56444019	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000181195.11	.	.	.	8q12.1	C3L-01971	.	.	.	.	.	.	.	.	.	0.13	T	T	.	.	.	N	.	.	N	0.050	T	T	T	0.058	0.374	0.113	.	.	.	T	T	T	T	0.221	3.367	0.856	N	N	-0.672	0.861	-0.890	0.634	0.000	0.497	0.590	0.563	0.542	.	2.960	-1.140	-0.545	-0.006	0.599	0.000	0.004	0.109	759	.	.	.	.	PENK	68	0	200	55	0.215686274509804	TRUE	TRUE
ENSG00000046889.19	.	BCM	GRCh38.p13	chr8	67952568	67952568	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000046889.19	.	.	.	8q13.2	C3L-01971	2.008e-05	0	0	0	0	3.78e-05	0	0	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55756819;OCCURENCE=1(large_intestine)	PREX2	197	1	494	130	0.208333333333333	TRUE	NA
ENSG00000079102.16	.	BCM	GRCh38.p13	chr8	91979826	91979826	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000079102.16	.	.	.	8q21.3	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RUNX1T1	152	0	250	66	0.208860759493671	TRUE	NA
ENSG00000184428.13	.	BCM	GRCh38.p13	chr8	143328302	143328302	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000184428.13	.	.	.	8q24.3	C3L-01971	.	.	.	.	.	.	.	.	rs921883903	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TOP1MT	159	0	380	32	0.0776699029126214	TRUE	NA
ENSG00000280486.2	.	BCM	GRCh38.p13	chr19	1388972	1388972	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000280486.2	.	.	.	19p13.3	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC005329.3	162	0	351	82	0.189376443418014	TRUE	NA
ENSG00000198223.16	.	BCM	GRCh38.p13	chrX	1268852	1268852	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000198223.16	ENST00000381524.8:c.-13852G>A	.	.	Xp22.33	C3L-01971	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CSF2RA	245	0	540	40	0.0689655172413793	TRUE	NA
ENSG00000162490.7	.	BCM	GRCh38.p13	chr1	11709328	11709328	+	G	G	A	Missense_Mutation	SNP	ENST00000294485.6	exon3	c.G505A	p.E169K	exonic	ENSG00000162490.7	.	nonsynonymous SNV	ENSG00000162490.7:ENST00000294485.6:exon3:c.G505A:p.E169K	1p36.22	C3L-02604	8.588e-06	9.954e-05	0	0	0	0	0	0	rs762451052	3.20	T	T	D	B	N	D	L	T	N	0.260	T	T	T	0.150	.	0.377	0.275	T	T	T	T	T	T	1.826	17.930	0.996	D	N	0.055	2.711	0.068	2.608	1.000	0.696	0.547	0.723	0.605	.	5.420	4.510	1.985	1.176	0.676	0.865	0.039	0.082	878	.	.	.	.	DRAXIN	145	0	233	95	0.289634146341463	TRUE	NA
ENSG00000162599.17	.	BCM	GRCh38.p13	chr1	61406638	61406638	+	C	C	T	Missense_Mutation	SNP	ENST00000403491.8	exon9	c.C1331T	p.P444L	exonic	ENSG00000162599.17	.	nonsynonymous SNV	ENSG00000162599.17:ENST00000403491.8:exon9:c.C1331T:p.P444L	1p31.3	C3L-02604	8.606e-06	0	0	0	0	0	0	6.378e-05	rs761025450	14.20	D	D	D	D	D	D	M	T	D	0.815	T	T	D	0.249	.	0.459	1.888	D	T	T	T	D	D	4.034	27.200	0.999	D	D	0.779	8.387	0.791	9.864	1.000	0.563	0.590	0.618	0.636	.	5.990	5.990	7.384	1.026	0.599	1.000	0.943	0.987	957	.	.	.	ID=COSV63607764;OCCURENCE=1(large_intestine)	NFIA	173	0	255	81	0.241071428571429	TRUE	TRUE
ENSG00000143067.5	.	BCM	GRCh38.p13	chr1	119623436	119623436	+	C	C	T	Missense_Mutation	SNP	ENST00000421812.3	exon3	c.G907A	p.D303N	exonic	ENSG00000143067.5	.	nonsynonymous SNV	ENSG00000143067.5:ENST00000421812.3:exon3:c.G907A:p.D303N	1p12	C3L-02604	.	.	.	.	.	.	.	.	.	3.19	T	T	D	P	.	N	N	T	N	0.106	T	T	D	0.095	0.236	0.055	0.641	D	T	T	T	T	T	1.605	16.400	0.916	N	N	-0.585	1.015	-0.640	0.987	1.000	0.701	0.546	0.717	0.636	.	4.230	3.320	-1.033	0.085	-0.393	0.000	0.005	0.001	665	Zinc_finger_C2H2-type	.	.	.	ZNF697	236	0	334	108	0.244343891402715	TRUE	TRUE
ENSG00000143847.15	.	BCM	GRCh38.p13	chr1	203043962	203043962	+	C	C	G	Missense_Mutation	SNP	ENST00000447715.6	exon8	c.C368G	p.S123C	exonic	ENSG00000143847.15	.	nonsynonymous SNV	ENSG00000143847.15:ENST00000447715.6:exon8:c.C368G:p.S123C	1q32.1	C3L-02604	.	.	.	.	.	.	.	.	.	12.18	D	D	.	.	D	D	M	T	D	0.698	T	T	D	0.380	0.259	0.720	.	D	T	T	T	D	D	3.866	26.200	0.994	D	D	0.744	7.783	0.734	8.433	1.000	0.706	0.710	0.659	0.542	.	4.870	4.870	7.905	1.026	0.599	1.000	1.000	0.999	734	.	.	.	.	PPFIA4	68	0	126	41	0.245508982035928	TRUE	TRUE
ENSG00000135801.9	.	BCM	GRCh38.p13	chr1	229602637	229602637	+	C	C	T	Missense_Mutation	SNP	ENST00000258281.6	exon4	c.G530A	p.R177H	exonic	ENSG00000135801.9	.	nonsynonymous SNV	ENSG00000135801.9:ENST00000258281.6:exon4:c.G530A:p.R177H	1q42.13	C3L-02604	8.237e-06	0	0	0	0	0	0	6.056e-05	rs762046097	13.20	D	T	D	D	D	D	M	T	D	0.831	T	T	D	0.377	0.753	0.507	0.471	T	T	D	D	D	T	4.084	27.600	1.000	D	D	0.681	6.858	0.723	8.197	1.000	0.707	0.702	0.725	0.714	.	5.690	5.690	7.552	1.026	0.599	1.000	1.000	1.000	517	TFIID_subunit_TAF5,_NTD2_domain	.	.	.	TAF5L	243	0	312	85	0.214105793450882	TRUE	NA
ENSG00000115705.22	.	BCM	GRCh38.p13	chr2	1504038	1504038	+	C	C	T	Missense_Mutation	SNP	ENST00000329066.9	exon14	c.C2477T	p.A826V	exonic	ENSG00000115705.22	.	nonsynonymous SNV	ENSG00000115705.22:ENST00000329066.9:exon14:c.C2477T:p.A826V	2p25.3	C3L-02604	8.247e-06	0	0	0	0	1.5e-05	0	0	rs748124213	5.20	D	D	P	B	N	N	N	D	N	0.163	T	T	D	0.248	.	0.766	0.163	T	D	T	T	T	T	0.849	9.890	0.973	N	N	-0.950	0.460	-1.040	0.441	0.802	0.487	0.574	0.547	0.613	.	4.400	1.480	0.200	-1.562	-0.262	0.000	0.000	0.001	900	EGF-like,_conserved_site;EGF-like_domain;EGF-like_calcium-binding_domain	.	.	ID=COSV61095654;OCCURENCE=1(large_intestine),2(stomach)	TPO	412	0	594	181	0.233548387096774	TRUE	TRUE
ENSG00000188177.14	.	BCM	GRCh38.p13	chr2	112322887	112322887	+	A	A	G	Missense_Mutation	SNP	ENST00000409871.6	exon9	c.A1325G	p.H442R	exonic	ENSG00000188177.14	.	nonsynonymous SNV	ENSG00000188177.14:ENST00000409871.6:exon9:c.A1325G:p.H442R	2q14.1	C3L-02604	.	.	.	.	.	.	.	.	.	7.20	D	T	P	B	D	D	L	T	N	0.277	T	T	T	0.200	0.437	0.139	0.305	T	T	T	T	D	D	3.092	23.600	0.989	D	D	0.437	4.578	0.527	5.413	1.000	0.638	0.670	0.659	0.568	.	5.430	5.430	8.639	1.295	0.756	1.000	1.000	0.999	934	.	.	.	.	ZC3H6	72	0	101	44	0.303448275862069	TRUE	TRUE
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140903028	140903028	+	T	T	A	Missense_Mutation	SNP	ENST00000389484.8	exon23	c.A3658T	p.N1220Y	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon23:c.A3658T:p.N1220Y	2q22.1	C3L-02604	.	.	.	.	.	.	.	.	.	7.20	D	D	B	B	N	N	L	D	N	0.211	T	D	D	0.212	0.489	0.316	0.611	T	T	T	T	D	T	2.302	21.600	0.976	D	N	-0.577	1.030	-0.554	1.116	0.000	0.487	0.574	0.547	0.564	.	5.530	3.020	0.930	0.133	0.665	0.685	0.411	0.952	934	EGF-like_domain	.	.	.	LRP1B	224	0	366	60	0.140845070422535	TRUE	TRUE
ENSG00000119041.11	.	BCM	GRCh38.p13	chr2	196772918	196772918	+	G	G	C	Missense_Mutation	SNP	ENST00000263956.8	exon14	c.C2067G	p.I689M	exonic	ENSG00000119041.11	.	nonsynonymous SNV	ENSG00000119041.11:ENST00000263956.8:exon14:c.C2067G:p.I689M	2q33.1	C3L-02604	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	D	D	L	T	N	0.847	T	T	T	0.163	0.378	0.672	1.161	T	T	T	T	D	D	4.198	28.600	0.997	D	D	0.428	4.524	0.465	4.854	0.745	0.707	0.725	0.725	0.714	.	4.750	4.750	4.903	1.176	0.676	1.000	0.999	0.975	240	.	.	.	.	GTF3C3	37	0	54	10	0.15625	TRUE	TRUE
ENSG00000116117.18	.	BCM	GRCh38.p13	chr2	205615578	205615578	+	G	G	A	Missense_Mutation	SNP	ENST00000406610.7	exon23	c.G3383A	p.R1128H	exonic	ENSG00000116117.18	.	nonsynonymous SNV	ENSG00000116117.18:ENST00000406610.7:exon23:c.G3383A:p.R1128H	2q33.3	C3L-02604	6.63e-05	0.0002	8.645e-05	0.0006	0	0	0	0	rs200129953	0.20	T	T	B	B	N	N	L	T	N	0.278	T	T	T	0.066	.	0.389	0.024	T	T	T	T	T	T	1.910	18.570	0.943	N	N	-0.612	0.966	-0.592	1.059	0.266	0.615	0.590	0.659	0.580	.	5.750	3.870	3.122	1.106	0.596	0.823	0.499	0.032	882	.	.	.	.	PARD3B	151	0	228	90	0.283018867924528	TRUE	NA
ENSG00000055955.17	.	BCM	GRCh38.p13	chr3	52823675	52823675	+	C	C	T	Missense_Mutation	SNP	ENST00000266041.9	exon11	c.G1420A	p.V474M	exonic	ENSG00000055955.17	.	nonsynonymous SNV	ENSG00000055955.17:ENST00000266041.9:exon11:c.G1420A:p.V474M	3p21.1	C3L-02604	4.945e-05	0.0003	0	0.0001	0	2.999e-05	0	0	rs201445354	13.20	D	D	D	D	D	D	H	T	D	0.313	T	T	D	0.314	.	0.437	0.956	T	D	T	T	D	D	3.062	23.500	0.999	N	D	0.398	4.329	0.214	3.254	1.000	0.615	0.588	0.659	0.621	.	4.560	4.560	1.033	1.026	0.599	0.215	0.223	0.334	82	.	.	.	.	ITIH4	282	1	394	121	0.23495145631068	TRUE	NA
ENSG00000144802.11	.	BCM	GRCh38.p13	chr3	101859324	101859324	+	C	C	G	Missense_Mutation	SNP	ENST00000326172.9	exon12	c.C2110G	p.R704G	exonic	ENSG00000144802.11	.	nonsynonymous SNV	ENSG00000144802.11:ENST00000326172.9:exon12:c.C2110G:p.R704G	3q12.3	C3L-02604	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.763	T	T	D	0.315	0.595	0.383	0.533	T	D	D	D	D	D	3.456	24.600	0.998	D	D	0.195	3.282	0.223	3.297	1.000	0.722	0.699	0.725	0.711	.	5.530	3.620	3.065	-0.244	-0.226	1.000	0.994	0.981	874	.	.	.	ID=COSV100396872;OCCURENCE=1(biliary_tract)	NFKBIZ	244	0	307	85	0.216836734693878	TRUE	TRUE
ENSG00000121879.5	.	BCM	GRCh38.p13	chr3	179218294	179218294	+	G	G	A	Missense_Mutation	SNP	ENST00000263967.4	exon10	c.G1624A	p.E542K	exonic	ENSG00000121879.5	.	nonsynonymous SNV	ENSG00000121879.5:ENST00000263967.4:exon10:c.G1624A:p.E542K	3q26.32	C3L-02604	.	.	.	.	.	.	.	.	rs121913273	14.20	D	T	D	D	D	D	L	T	N	0.957	T	T	D	0.439	0.719	0.877	2.798	D	D	D	D	D	D	4.466	32	0.999	D	D	0.612	6.048	0.672	7.254	1.000	0.732	0.710	0.659	0.728	.	5.780	5.780	9.602	1.176	0.618	1.000	1.000	0.997	799	Phosphoinositide_3-kinase,_accessory_(PIK)_domain	.	.	ID=COSV55873227;OCCURENCE=11(salivary_gland),611(breast),8(penis),12(liver),2(genital_tract),29(oesophagus),56(cervix),462(large_intestine),25(central_nervous_system),11(biliary_tract),6(vulva),39(ovary),1(bone),4(NS),4(haematopoietic_and_lymphoid_tissue),40(stomach),16(soft_tissue),14(kidney),110(urinary_tract),5(pancreas),5(gastrointestinal_tract_(site_indeterminate)),1(pituitary),34(skin),8(prostate),68(lung),27(thyroid),75(upper_aerodigestive_tract),3(testis),1(thymus),3(small_intestine),81(endometrium)	PIK3CA	106	0	204	54	0.209302325581395	NA	TRUE
ENSG00000178597.7	.	BCM	GRCh38.p13	chr4	7434347	7434347	+	G	G	A	Missense_Mutation	SNP	ENST00000319098.7	exon1	c.C533T	p.A178V	exonic	ENSG00000178597.7	.	nonsynonymous SNV	ENSG00000178597.7:ENST00000319098.7:exon1:c.C533T:p.A178V	4p16.1	C3L-02604	1.061e-05	0	0	0	0	1.904e-05	0	0	rs763107725	0.19	T	T	B	B	.	N	N	T	N	0.013	T	T	T	0.031	.	0.391	0.026	T	T	T	T	T	T	-0.454	0.148	0.807	N	N	-1.931	0.013	-1.980	0.015	1.000	0.487	0.574	0.547	0.613	.	3.470	-6.940	-0.609	-0.450	-1.442	0.000	0.000	0.000	994	.	.	.	.	PSAPL1	189	1	306	94	0.235	TRUE	NA
ENSG00000145375.8	.	BCM	GRCh38.p13	chr4	123256125	123256125	+	A	A	G	Missense_Mutation	SNP	ENST00000274008.5	exon15	c.A2450G	p.N817S	exonic	ENSG00000145375.8	.	nonsynonymous SNV	ENSG00000145375.8:ENST00000274008.5:exon15:c.A2450G:p.N817S	4q28.1	C3L-02604	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	N	N	.	D	N	0.125	T	T	D	0.173	0.429	0.709	0.113	T	T	T	T	T	D	0.571	7.225	0.573	N	N	-1.073	0.331	-1.036	0.445	0.094	0.693	0.634	0.659	0.655	.	4.870	0.948	1.444	1.312	0.756	0.007	0.095	0.025	127	.	.	.	.	SPATA5	172	0	260	68	0.207317073170732	TRUE	TRUE
ENSG00000039139.9	.	BCM	GRCh38.p13	chr5	13810124	13810124	+	G	G	A	Missense_Mutation	SNP	ENST00000265104.4	exon45	c.C7544T	p.T2515M	exonic	ENSG00000039139.9	.	nonsynonymous SNV	ENSG00000039139.9:ENST00000265104.4:exon45:c.C7544T:p.T2515M	5p15.2	C3L-02604	.	.	.	.	.	.	.	.	.	0.19	T	.	B	B	N	N	L	T	N	0.144	T	T	T	0.086	0.272	0.478	0.392	T	T	T	T	T	T	1.142	13.150	0.920	N	N	-0.798	0.657	-0.861	0.673	0.001	0.487	0.574	0.547	0.613	.	5.100	0.471	0.791	0.980	0.674	0.000	0.001	0.034	684	.	.	.	ID=COSV54224881;OCCURENCE=1(large_intestine),1(stomach)	DNAH5	264	0	395	132	0.250474383301708	TRUE	TRUE
ENSG00000040731.10	.	BCM	GRCh38.p13	chr5	24537485	24537485	+	C	C	A	Nonsense_Mutation	SNP	ENST00000264463.8	exon3	c.G421T	p.E141X	exonic	ENSG00000040731.10	.	stopgain	ENSG00000040731.10:ENST00000264463.8:exon3:c.G421T:p.E141X	5p14.2	C3L-02604	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.429	.	.	.	.	.	.	.	.	.	D	D	.	.	7.118	37	0.998	D	N	1.212	24.837	1.082	25.101	1.000	0.487	0.574	0.574	0.564	.	5.820	5.820	7.905	1.015	0.599	1.000	0.999	0.993	783	Cadherin-like	.	.	ID=COSV100050671;OCCURENCE=1(stomach)	CDH10	353	0	470	130	0.216666666666667	TRUE	TRUE
ENSG00000204516.10	.	BCM	GRCh38.p13	chr6	31509908	31509908	+	A	A	C	Nonstop_Mutation	SNP	ENST00000252229.7	exon6	c.A1151C	p.X384S	exonic	ENSG00000204516.10	.	stoploss	ENSG00000204516.10:ENST00000252229.7:exon6:c.A1151C:p.X384S	6p21.33	C3L-02604	.	.	.	.	.	.	.	.	.	0.4	.	.	.	.	.	N	.	.	.	0.213	.	.	.	.	.	.	.	.	.	T	T	.	.	-0.320	0.284	0.699	N	.	0.047	2.684	-0.394	1.384	0.186	0.295	0.272	0.320	0.323	0.050	1.310	1.310	-0.389	0.636	0.393	0.000	0.005	0.009	934	.	.	.	.	MICB	71	0	94	30	0.241935483870968	TRUE	TRUE
ENSG00000112164.6	.	BCM	GRCh38.p13	chr6	39072920	39072920	+	C	C	T	Nonsense_Mutation	SNP	ENST00000373256.5	exon6	c.C568T	p.R190X	exonic	ENSG00000112164.6	.	stopgain	ENSG00000112164.6:ENST00000373256.5:exon6:c.C568T:p.R190X	6p21.2	C3L-02604	8.237e-06	0	0	0	0	1.498e-05	0	0	rs763103077	5.6	.	.	.	.	D	A	.	.	.	0.953	.	.	.	.	.	.	.	.	.	D	D	.	.	7.675	39	0.998	D	N	0.268	3.617	0.087	2.681	0.999	0.653	0.563	0.676	0.530	.	5.710	3.900	1.200	0.129	-0.218	0.677	0.990	0.986	780	GPCR,_family_2-like	.	.	ID=COSV100952773;OCCURENCE=1(endometrium)	GLP1R	185	0	274	93	0.253405994550409	TRUE	NA
ENSG00000010810.17	.	BCM	GRCh38.p13	chr6	111694504	111694504	+	C	C	A	Nonsense_Mutation	SNP	ENST00000354650.7	exon12	c.G1144T	p.E382X	exonic	ENSG00000010810.17	.	stopgain	ENSG00000010810.17:ENST00000354650.7:exon12:c.G1144T:p.E382X	6q21	C3L-02604	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.986	.	.	.	.	.	.	.	.	.	D	D	.	.	8.084	41	0.998	D	N	1.243	28.311	1.115	28.870	1.000	0.722	0.725	0.725	0.735	.	5.950	5.950	7.905	1.026	0.599	1.000	0.999	0.996	173	Tyrosine-protein_kinase,_catalytic_domain;Protein_kinase_domain;Serine-threonine/tyrosine-protein_kinase,_catalytic_domain	.	.	.	FYN	130	0	197	85	0.301418439716312	TRUE	TRUE
ENSG00000106571.14	.	BCM	GRCh38.p13	chr7	42026344	42026344	+	C	C	T	Missense_Mutation	SNP	ENST00000395925.8	exon8	c.G1097A	p.R366Q	exonic	ENSG00000106571.14	.	nonsynonymous SNV	ENSG00000106571.14:ENST00000395925.8:exon8:c.G1097A:p.R366Q	7p14.1	C3L-02604	8.272e-06	0	0	0	0	1.501e-05	0	0	rs774754578	7.20	T	T	B	B	D	D	N	T	N	0.672	T	T	D	0.222	0.323	0.513	0.661	T	T	T	T	D	D	2.284	21.500	0.864	D	D	0.091	2.852	0.298	3.703	1.000	0.644	0.590	0.688	0.636	.	5.900	5.900	7.347	1.025	0.599	1.000	1.000	0.995	905	.	.	.	ID=COSV67889423;OCCURENCE=1(endometrium)	GLI3	707	2	961	248	0.205128205128205	TRUE	TRUE
ENSG00000015520.14	.	BCM	GRCh38.p13	chr7	44522066	44522067	+	TG	TG	-	Frame_Shift_Del	DEL	ENST00000289547.8	exon11	c.2813_2814del	p.T938Rfs*4	exonic	ENSG00000015520.14	.	frameshift deletion	ENSG00000015520.14:ENST00000289547.8:exon11:c.2813_2814del:p.T938Rfs*4	7p13	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NPC1L1	179	0	235	80	0.253968253968254	TRUE	TRUE
ENSG00000009950.16	.	BCM	GRCh38.p13	chr7	73597395	73597395	+	T	T	G	Missense_Mutation	SNP	ENST00000313375.8	exon9	c.A1390C	p.S464R	exonic	ENSG00000009950.16	.	nonsynonymous SNV	ENSG00000009950.16:ENST00000313375.8:exon9:c.A1390C:p.S464R	7q11.23	C3L-02604	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.169	T	T	T	0.017	.	0.043	0.104	T	T	T	T	T	T	0.303	4.330	0.164	N	N	-1.226	0.209	-1.229	0.260	0.232	0.646	0.574	0.645	0.563	.	3.900	1.970	0.276	-0.019	-0.352	0.023	0.047	0.004	900	.	.	.	.	MLXIPL	10	0	15	8	0.347826086956522	TRUE	NA
ENSG00000006453.14	.	BCM	GRCh38.p13	chr7	98307735	98307735	+	C	C	T	Missense_Mutation	SNP	ENST00000005260.9	exon10	c.G1117A	p.E373K	exonic	ENSG00000006453.14	.	nonsynonymous SNV	ENSG00000006453.14:ENST00000005260.9:exon10:c.G1117A:p.E373K	7q21.3	C3L-02604	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	L	T	D	0.612	T	T	D	0.351	0.713	0.799	0.776	T	T	T	T	D	D	4.185	28.500	0.999	D	D	0.667	6.683	0.657	7.020	1.000	0.719	0.723	0.723	0.646	.	4.870	4.870	7.503	1.026	0.599	1.000	0.988	0.909	799	SH3_domain;IRTKS,_SH3_domain	.	.	ID=COSV50056804;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	BAIAP2L1	331	0	430	135	0.238938053097345	TRUE	TRUE
ENSG00000008311.15	.	BCM	GRCh38.p13	chr7	122133591	122133591	+	G	G	T	Missense_Mutation	SNP	ENST00000417368.7	exon2	c.C136A	p.H46N	exonic	ENSG00000008311.15	.	nonsynonymous SNV	ENSG00000008311.15:ENST00000417368.7:exon2:c.C136A:p.H46N	7q31.32	C3L-02604	.	.	.	.	.	.	.	.	.	10.20	T	T	P	P	D	D	L	T	D	0.866	T	T	D	0.499	0.591	0.906	0.661	T	D	D	T	D	D	3.282	24.100	0.986	D	D	0.584	5.766	0.638	6.727	1.000	0.706	0.670	0.696	0.613	.	5.320	5.320	9.904	1.175	0.676	1.000	0.956	0.969	609	Alanine_dehydrogenase/pyridine_nucleotide_transhydrogenase,_N-terminal	.	.	.	AASS	557	0	825	266	0.243813015582035	TRUE	TRUE
ENSG00000147485.13	.	BCM	GRCh38.p13	chr8	51472280	51472280	+	G	G	A	Missense_Mutation	SNP	ENST00000356297.5	exon8	c.C719T	p.P240L	exonic	ENSG00000147485.13	.	nonsynonymous SNV	ENSG00000147485.13:ENST00000356297.5:exon8:c.C719T:p.P240L	8q11.22	C3L-02604	1.657e-05	0	0.0002	0	0	0	0	0	rs760527870	10.19	D	D	D	D	.	D	L	T	D	0.638	T	T	T	0.405	0.729	0.544	0.556	T	T	T	T	D	D	3.409	24.400	0.998	D	D	0.437	4.583	0.308	3.763	0.971	0.554	0.574	0.618	0.564	.	3.840	3.840	8.547	1.006	0.618	1.000	0.046	0.396	912	Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	ID=COSV62488380;OCCURENCE=1(breast),1(large_intestine),1(lung)	PXDNL	127	0	163	38	0.189054726368159	TRUE	TRUE
ENSG00000176571.12	.	BCM	GRCh38.p13	chr8	87284765	87284765	+	G	G	A	Missense_Mutation	SNP	ENST00000518476.6	exon7	c.G859A	p.D287N	exonic	ENSG00000176571.12	.	nonsynonymous SNV	ENSG00000176571.12:ENST00000518476.6:exon7:c.G859A:p.D287N	8q21.3	C3L-02604	9.566e-05	0.0007	0	0	0	5.963e-05	0	0	rs370856044	6.20	T	T	D	P	N	N	L	D	N	0.248	D	D	D	0.257	.	0.374	0.008	T	T	T	T	T	T	2.561	22.600	0.995	D	N	0.273	3.641	0.178	3.076	0.016	0.487	0.574	0.574	0.564	.	5.250	5.250	2.351	1.121	0.618	0.845	0.320	0.320	656	.	.	.	ID=COSV73072544;OCCURENCE=1(stomach),4(skin)	CNBD1	135	0	179	49	0.214912280701754	TRUE	TRUE
ENSG00000122728.6	.	BCM	GRCh38.p13	chr9	32633406	32633406	+	C	C	T	Missense_Mutation	SNP	ENST00000242310.4	exon1	c.G2174A	p.R725Q	exonic	ENSG00000122728.6	.	nonsynonymous SNV	ENSG00000122728.6:ENST00000242310.4:exon1:c.G2174A:p.R725Q	9p21.1	C3L-02604	1.647e-05	0	0	0	0	2.997e-05	0	0	rs145899352	10.20	D	D	D	D	D	D	M	T	D	0.107	T	T	T	0.208	.	0.503	0.372	T	T	T	T	D	D	2.850	23.100	0.999	N	N	0.137	3.035	-0.107	2.026	0.064	0.706	0.659	0.710	0.613	.	0.633	-0.574	0.829	0.275	0.240	1.000	0.928	0.833	835	Transcription_initiation_factor_TFIID_subunit_1,_domain_of_unknown_function	.	.	ID=COSV54262132;OCCURENCE=1(lung)	TAF1L	366	0	338	172	0.337254901960784	TRUE	TRUE
ENSG00000137094.14	.	BCM	GRCh38.p13	chr9	34996579	34996579	+	C	C	T	Missense_Mutation	SNP	ENST00000545841.5	exon3	c.C526T	p.R176W	exonic	ENSG00000137094.14	.	nonsynonymous SNV	ENSG00000137094.14:ENST00000545841.5:exon3:c.C526T:p.R176W	9p13.3	C3L-02604	.	.	.	.	.	.	.	.	.	10.20	T	T	D	B	N	D	M	D	N	0.434	T	T	D	0.437	0.525	0.875	1.040	D	T	T	T	D	D	2.393	22.100	0.998	D	D	0.029	2.618	0.026	2.449	1.000	0.707	0.634	0.698	0.714	.	5.110	0.996	1.110	1.026	0.599	1.000	1.000	1.000	139	Chaperone_DnaJ,_C-terminal	.	.	ID=COSV100257705;OCCURENCE=1(biliary_tract)	DNAJB5	405	1	637	332	0.342621259029928	TRUE	NA
ENSG00000157654.19	.	BCM	GRCh38.p13	chr9	110136527	110136527	+	C	C	T	Missense_Mutation	SNP	ENST00000259318.7	exon2	c.C290T	p.A97V	exonic	ENSG00000157654.19	.	nonsynonymous SNV	ENSG00000157654.19:ENST00000259318.7:exon2:c.C290T:p.A97V	9q31.3	C3L-02604	7.419e-05	0	0.0003	0	0	0	0	0.0004	rs147894013	0.20	T	T	B	B	N	N	L	T	N	0.096	T	T	T	0.123	.	0.153	0.083	T	T	T	T	T	T	0.634	7.839	0.930	N	N	-0.833	0.609	-0.791	0.770	1.000	0.722	0.702	0.710	0.735	.	6.170	4.290	0.482	-0.215	0.599	0.000	0.000	0.001	917	.	.	.	ID=COSV52179816;OCCURENCE=1(upper_aerodigestive_tract)	PALM2AKAP2	182	0	285	109	0.276649746192893	TRUE	TRUE
ENSG00000148204.12	.	BCM	GRCh38.p13	chr9	123367210	123367210	+	T	T	C	Missense_Mutation	SNP	ENST00000373631.8	exon5	c.T793C	p.C265R	exonic	ENSG00000148204.12	.	nonsynonymous SNV	ENSG00000148204.12:ENST00000373631.8:exon5:c.T793C:p.C265R	9q33.3	C3L-02604	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	H	D	D	0.980	D	D	D	0.908	0.959	0.993	0.505	D	D	D	D	D	D	4.010	27.000	0.996	D	D	0.836	9.532	0.680	7.392	1.000	0.646	0.541	0.645	0.563	.	5.100	5.100	7.699	1.127	0.640	1.000	0.952	0.304	373	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	CRB2	133	0	198	67	0.252830188679245	TRUE	TRUE
ENSG00000260314.3	.	BCM	GRCh38.p13	chr10	17856260	17856260	+	C	C	T	Missense_Mutation	SNP	ENST00000569591.3	exon9	c.C1426T	p.R476W	exonic	ENSG00000260314.3	.	nonsynonymous SNV	ENSG00000260314.3:ENST00000569591.3:exon9:c.C1426T:p.R476W	10p12.33	C3L-02604	0	0	0	0	0	0	0	0	rs782693726	5.20	T	T	D	D	U	N	L	T	D	0.172	T	T	T	0.150	0.750	0.213	.	T	T	T	T	D	D	2.415	22.100	0.998	N	N	-0.226	1.804	-0.374	1.419	0.000	0.554	0.574	0.574	0.621	.	4.580	2.540	-0.254	0.074	0.599	0.000	0.097	0.526	923	C-type_lectin-like;C-type_lectin,_conserved_site	.	.	.	MRC1	529	0	694	196	0.220224719101124	TRUE	NA
ENSG00000177354.12	.	BCM	GRCh38.p13	chr10	49326721	49326721	+	C	C	A	Nonsense_Mutation	SNP	ENST00000374144.8	exon3	c.C4176A	p.C1392X	exonic	ENSG00000177354.12	.	stopgain	ENSG00000177354.12:ENST00000374144.8:exon3:c.C4176A:p.C1392X	10q11.23	C3L-02604	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	U	D	.	.	.	0.047	.	.	.	.	.	.	.	.	.	D	D	.	.	6.456	36	0.970	N	N	-0.022	2.435	-0.421	1.335	0.619	0.487	0.590	0.547	0.564	.	5.320	-3.250	-0.412	0.138	0.544	0.000	0.001	0.036	894	.	.	.	.	C10orf71	357	0	498	177	0.262222222222222	TRUE	TRUE
ENSG00000204033.10	.	BCM	GRCh38.p13	chr10	84225450	84225450	+	C	C	A	Missense_Mutation	SNP	ENST00000372113.7	exon1	c.G71T	p.C24F	exonic	ENSG00000204033.10	.	nonsynonymous SNV	ENSG00000204033.10:ENST00000372113.7:exon1:c.G71T:p.C24F	10q23.1	C3L-02604	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.569	D	D	D	0.632	0.735	0.648	0.021	T	T	D	D	D	T	2.947	23.300	0.990	D	D	0.453	4.689	0.334	3.920	0.779	0.497	0.590	0.547	0.613	.	5.870	4.960	3.330	1.026	0.599	1.000	0.789	0.785	930	Proteinase_inhibitor_I2,_Kunitz,_conserved_site	.	.	.	LRIT2	169	1	238	77	0.244444444444444	TRUE	TRUE
ENSG00000148848.14	.	BCM	GRCh38.p13	chr10	126101214	126101214	+	C	C	T	Missense_Mutation	SNP	ENST00000368679.8	exon9	c.G778A	p.V260M	exonic	ENSG00000148848.14	.	nonsynonymous SNV	ENSG00000148848.14:ENST00000368679.8:exon9:c.G778A:p.V260M	10q26.2	C3L-02604	4.12e-05	9.612e-05	0	0.0001	0	4.496e-05	0	0	rs35025137	10.20	D	D	D	D	D	D	L	T	N	0.646	T	T	D	0.301	.	0.818	0.843	T	T	T	T	T	D	3.032	23.500	0.999	D	D	0.671	6.736	0.613	6.384	1.000	0.603	0.547	0.547	0.663	.	5.320	5.320	5.002	0.127	-0.175	1.000	0.476	0.679	845	Peptidase_M12B,_ADAM/reprolysin;Reprolysin_domain,_adamalysin-type	.	.	ID=COSV64114634;OCCURENCE=1(oesophagus)	ADAM12	135	0	168	119	0.414634146341463	TRUE	TRUE
ENSG00000175294.6	.	BCM	GRCh38.p13	chr11	66020615	66020615	+	A	A	T	Missense_Mutation	SNP	ENST00000312106.6	exon7	c.T1940A	p.I647N	exonic	ENSG00000175294.6	.	nonsynonymous SNV	ENSG00000175294.6:ENST00000312106.6:exon7:c.T1940A:p.I647N	11q13.1	C3L-02604	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	U	D	L	D	D	0.802	D	D	D	0.688	0.617	0.946	1.358	T	D	D	D	D	T	4.103	27.800	0.993	D	D	0.502	5.050	0.502	5.181	1.000	0.601	0.590	0.547	0.620	.	4.700	4.700	5.111	1.312	0.756	1.000	0.998	0.939	207	Ion_transport_domain	.	.	.	CATSPER1	400	0	552	162	0.226890756302521	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02604	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	266	0	244	133	0.352785145888594	TRUE	TRUE
ENSG00000013573.17	.	BCM	GRCh38.p13	chr12	31101869	31101869	+	G	G	A	Missense_Mutation	SNP	ENST00000545668.5	exon21	c.G2089A	p.G697S	exonic	ENSG00000013573.17	.	nonsynonymous SNV	ENSG00000013573.17:ENST00000545668.5:exon21:c.G2089A:p.G697S	12p11.21	C3L-02604	6.627e-05	0	0	0	0	8.997e-05	0	0.0001	rs748906306	2.19	T	T	P	B	N	D	.	D	N	0.227	T	T	T	0.244	.	0.906	.	T	T	T	T	T	T	1.385	14.980	0.860	N	N	-0.945	0.465	-0.903	0.617	0.000	0.672	0.702	0.702	0.684	.	3.720	1.170	4.627	-0.528	-1.013	1.000	0.204	0.011	976	ATP-dependent_helicase,_C-terminal	.	.	ID=COSV52501136;OCCURENCE=1(large_intestine)	DDX11	585	0	583	276	0.321303841676368	NA	TRUE
ENSG00000123360.12	.	BCM	GRCh38.p13	chr12	54575214	54575214	+	G	G	A	Missense_Mutation	SNP	ENST00000243052.8	exon11	c.G1181A	p.R394H	exonic	ENSG00000123360.12	.	nonsynonymous SNV	ENSG00000123360.12:ENST00000243052.8:exon11:c.G1181A:p.R394H	12q13.2	C3L-02604	4.127e-05	9.615e-05	0	0	0.0003	3.002e-05	0	0	rs143206355	17.20	D	D	D	D	D	D	M	D	D	0.525	D	D	D	0.552	.	0.876	1.175	T	D	T	T	D	D	4.256	29.200	0.999	D	D	0.784	8.471	0.744	8.657	0.999	0.563	0.654	0.602	0.542	.	5.250	5.250	5.729	1.176	0.676	1.000	1.000	0.968	691	3'5'-cyclic_nucleotide_phosphodiesterase,_catalytic_domain	.	.	ID=COSV99226542;OCCURENCE=1(upper_aerodigestive_tract)	PDE1B	152	0	204	63	0.235955056179775	TRUE	TRUE
ENSG00000139718.10	.	BCM	GRCh38.p13	chr12	121828048	121828048	+	G	G	A	Missense_Mutation	SNP	ENST00000604567.5	exon16	c.G5705A	p.R1902H	exonic	ENSG00000139718.10	.	nonsynonymous SNV	ENSG00000139718.10:ENST00000604567.5:exon16:c.G5705A:p.R1902H	12q24.31	C3L-02604	.	.	.	.	.	.	.	.	.	17.18	D	D	.	.	D	D	H	D	D	0.906	D	D	D	0.770	-	0.881	1.604	D	T	D	D	D	D	4.479	32	0.992	D	D	0.932	11.916	0.854	11.911	1.000	0.707	0.702	0.725	0.711	.	5.110	5.110	9.994	1.176	0.676	1.000	0.938	0.963	518	SET_domain	.	.	.	SETD1B	175	0	256	78	0.233532934131737	TRUE	TRUE
ENSG00000088451.11	.	BCM	GRCh38.p13	chr13	94592269	94592269	+	G	G	T	Missense_Mutation	SNP	ENST00000261296.7	exon3	c.C194A	p.S65Y	exonic	ENSG00000088451.11	.	nonsynonymous SNV	ENSG00000088451.11:ENST00000261296.7:exon3:c.C194A:p.S65Y	13q32.1	C3L-02604	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.367	D	D	D	0.739	0.562	0.895	0.661	T	D	D	D	D	D	3.171	23.800	0.994	D	D	0.601	5.929	0.575	5.929	1.000	0.707	0.725	0.725	0.714	.	5.630	4.780	4.289	1.176	0.676	1.000	1.000	0.999	909	NAD(P)-binding_domain	.	.	.	TGDS	79	0	136	26	0.160493827160494	TRUE	TRUE
ENSG00000211797.2	.	BCM	GRCh38.p13	chr14	21997958	21997958	+	T	T	C	Missense_Mutation	SNP	ENST00000390445.2	exon2	c.T127C	p.C43R	exonic	ENSG00000211797.2	.	nonsynonymous SNV	ENSG00000211797.2:ENST00000390445.2:exon2:c.T127C:p.C43R	14q11.2	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TRAV17	63	0	122	36	0.227848101265823	TRUE	TRUE
ENSG00000100644.17	.	BCM	GRCh38.p13	chr14	61721775	61721775	+	C	C	T	Missense_Mutation	SNP	ENST00000337138.9	exon4	c.C409T	p.H137Y	exonic	ENSG00000100644.17	.	nonsynonymous SNV	ENSG00000100644.17:ENST00000337138.9:exon4:c.C409T:p.H137Y	14q23.2	C3L-02604	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	H	T	D	0.919	T	T	D	0.706	0.833	0.773	1.921	D	D	D	D	D	D	3.962	26.700	0.998	D	D	1.007	14.157	0.945	15.845	1.000	0.732	0.744	0.744	0.714	.	5.750	5.750	7.905	1.026	0.599	1.000	1.000	0.996	677	PAS_fold;PAS_domain	.	.	.	HIF1A	170	0	244	76	0.2375	TRUE	TRUE
ENSG00000102882.12	.	BCM	GRCh38.p13	chr16	30121915	30121915	+	C	C	T	Missense_Mutation	SNP	ENST00000263025.9	exon2	c.G262A	p.E88K	exonic	ENSG00000102882.12	.	nonsynonymous SNV	ENSG00000102882.12:ENST00000263025.9:exon2:c.G262A:p.E88K	16p11.2	C3L-02604	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.978	D	D	D	0.939	0.904	0.969	1.778	D	T	D	D	D	D	4.178	28.500	0.999	D	D	1.006	14.099	0.922	14.744	1.000	0.706	0.710	0.644	0.562	.	5.630	5.630	7.858	1.026	0.599	1.000	0.890	0.917	150	Mitogen-activated_protein_(MAP)_kinase,_conserved_site;Protein_kinase_domain	.	.	.	MAPK3	452	0	874	190	0.178571428571429	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675153	7675153	+	G	G	-	Frame_Shift_Del	DEL	ENST00000269305.8	exon5	c.459delC	p.G154Afs*16	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon5:c.459delC:p.G154Afs*16	17p13.1	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	244	0	191	118	0.381877022653722	TRUE	TRUE
ENSG00000108557.19	.	BCM	GRCh38.p13	chr17	17793232	17793232	+	C	C	T	Missense_Mutation	SNP	ENST00000353383.6	exon3	c.C284T	p.P95L	exonic	ENSG00000108557.19	.	nonsynonymous SNV	ENSG00000108557.19:ENST00000353383.6:exon3:c.C284T:p.P95L	17p11.2	C3L-02604	0.0001	0	0	0.0008	0	0	0	0.0004	rs370882080	9.20	D	D	P	B	N	D	M	T	D	0.346	T	T	D	0.176	.	0.481	0.518	T	D	T	T	T	D	2.290	21.500	0.989	D	N	0.038	2.651	0.056	2.559	0.998	0.563	0.654	0.607	0.684	.	4.550	4.550	1.917	0.947	0.599	0.893	0.357	0.457	313	.	.	.	.	RAI1	192	0	198	92	0.317241379310345	TRUE	NA
ENSG00000161381.14	.	BCM	GRCh38.p13	chr17	39151389	39151389	+	G	G	A	Missense_Mutation	SNP	ENST00000315392.9	exon1	c.C49T	p.R17W	exonic	ENSG00000161381.14	.	nonsynonymous SNV	ENSG00000161381.14:ENST00000315392.9:exon1:c.C49T:p.R17W	17q12	C3L-02604	.	.	.	.	.	.	.	.	.	3.20	D	T	P	P	N	N	L	T	N	0.181	T	T	D	0.140	0.417	0.194	0.245	D	T	T	T	T	T	2.182	20.700	0.952	N	N	-0.357	1.479	-0.447	1.290	1.000	0.658	0.596	0.619	0.639	.	3.310	-2.420	-0.104	-0.753	-2.103	0.001	0.423	0.751	599	.	.	.	.	PLXDC1	28	0	32	10	0.238095238095238	TRUE	NA
ENSG00000177469.13	.	BCM	GRCh38.p13	chr17	42405136	42405136	+	C	C	T	Missense_Mutation	SNP	ENST00000357037.6	exon2	c.G724A	p.E242K	exonic	ENSG00000177469.13	.	nonsynonymous SNV	ENSG00000177469.13:ENST00000357037.6:exon2:c.G724A:p.E242K	17q21.2	C3L-02604	.	.	.	.	.	.	.	.	.	10.19	T	D	D	P	D	D	.	T	N	0.468	T	T	D	0.197	0.156	0.918	.	D	T	T	T	D	D	4.063	27.400	0.998	D	D	0.571	5.641	0.596	6.178	1.000	0.722	0.634	0.723	0.735	.	5.480	5.480	4.928	1.026	0.539	1.000	1.000	0.998	511	.	.	.	.	CAVIN1	564	0	680	131	0.161528976572133	TRUE	TRUE
ENSG00000108821.14	.	BCM	GRCh38.p13	chr17	50199273	50199273	+	C	C	T	Missense_Mutation	SNP	ENST00000225964.10	exon5	c.G424A	p.G142R	exonic	ENSG00000108821.14	.	nonsynonymous SNV	ENSG00000108821.14:ENST00000225964.10:exon5:c.G424A:p.G142R	17q21.33	C3L-02604	.	.	.	.	.	.	.	.	.	14.15	D	D	.	.	N	D	.	D	D	0.955	D	D	D	0.943	0.968	0.988	0.671	D	.	D	D	D	.	4.434	31	0.999	D	D	0.950	12.428	0.840	11.427	1.000	0.660	0.547	0.663	0.568	.	5.150	5.150	5.501	1.026	0.597	0.999	1.000	0.999	897	.	.	.	.	COL1A1	88	0	127	28	0.180645161290323	TRUE	TRUE
ENSG00000108375.12	.	BCM	GRCh38.p13	chr17	58358746	58358746	+	G	G	A	Nonsense_Mutation	SNP	ENST00000584437.5	exon8	c.C1030T	p.Q344X	exonic	ENSG00000108375.12;ENSG00000285897.1	.	stopgain	ENSG00000108375.12:ENST00000584437.5:exon8:c.C1030T:p.Q344X,ENSG00000285897.1:ENST00000648873.1:exon8:c.C1030T:p.Q344X	17q22	C3L-02604	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	D	.	.	.	0.915	.	.	.	.	.	.	.	.	.	D	D	.	.	7.610	38	0.998	D	N	0.851	9.872	0.653	6.954	1.000	0.581	0.380	0.576	0.542	.	3.540	3.540	6.660	1.157	0.654	1.000	0.996	0.990	308	.	.	.	.	RNF43	87	0	104	38	0.267605633802817	TRUE	TRUE
ENSG00000134438.10	.	BCM	GRCh38.p13	chr18	59272431	59272431	+	G	G	T	Missense_Mutation	SNP	ENST00000334889.4	exon2	c.C473A	p.S158Y	exonic	ENSG00000134438.10	.	nonsynonymous SNV	ENSG00000134438.10:ENST00000334889.4:exon2:c.C473A:p.S158Y	18q21.32	C3L-02604	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	L	D	D	0.771	D	D	D	0.870	0.531	0.981	2.093	D	D	D	D	D	T	4.599	32	0.995	D	D	0.955	12.575	0.956	16.386	1.000	0.598	0.596	0.666	0.639	.	6.040	6.040	10.003	1.176	0.676	1.000	0.998	0.998	902	Homeobox_domain	.	.	.	RAX	298	0	311	155	0.332618025751073	TRUE	TRUE
ENSG00000141905.19	.	BCM	GRCh38.p13	chr19	3434282	3434282	+	G	G	A	Missense_Mutation	SNP	ENST00000443272.3	exon5	c.G715A	p.V239M	exonic	ENSG00000141905.19	.	nonsynonymous SNV	ENSG00000141905.19:ENST00000443272.3:exon5:c.G715A:p.V239M	19p13.3	C3L-02604	0.0002	0	8.711e-05	0.0001	0	1.534e-05	0	0.0014	rs529235700	11.20	D	T	D	D	D	D	M	T	N	0.913	T	T	D	0.274	0.663	0.703	1.400	D	T	T	T	T	D	4.150	28.200	0.998	D	D	0.630	6.244	0.551	5.655	1.000	0.722	0.686	0.576	0.735	.	3.480	3.480	8.430	1.176	0.676	1.000	0.982	0.947	970	.	.	.	ID=COSV59417612;OCCURENCE=1(pancreas)	NFIC	56	0	86	42	0.328125	TRUE	TRUE
ENSG00000196365.12	.	BCM	GRCh38.p13	chr19	5699049	5699049	+	C	C	T	Missense_Mutation	SNP	ENST00000360614.8	exon10	c.G1663A	p.V555M	exonic	ENSG00000196365.12	.	nonsynonymous SNV	ENSG00000196365.12:ENST00000360614.8:exon10:c.G1663A:p.V555M	19p13.3	C3L-02604	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.867	D	D	D	0.791	.	0.848	1.082	D	D	D	D	D	D	3.954	26.700	0.999	D	D	0.784	8.470	0.719	8.131	1.000	0.672	0.698	0.702	0.711	.	4.730	4.730	7.612	1.018	0.589	1.000	0.609	0.880	835	ATPase,_AAA-type,_core;AAA+_ATPase_domain	.	.	.	LONP1	117	0	111	52	0.319018404907975	TRUE	NA
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8106225	8106225	+	C	C	T	Missense_Mutation	SNP	ENST00000600128.6	exon38	c.G4696A	p.E1566K	exonic	ENSG00000142449.13	.	nonsynonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon38:c.G4696A:p.E1566K	19p13.2	C3L-02604	1.653e-05	9.653e-05	0	0	0	1.502e-05	0	0	rs765122699	17.20	D	D	D	P	U	D	M	D	D	0.881	D	D	D	0.909	0.875	0.910	0.777	T	D	D	D	D	D	3.966	26.800	0.999	D	D	0.765	8.139	0.619	6.475	1.000	0.707	0.547	0.725	0.564	.	3.250	3.250	7.407	0.877	0.599	1.000	0.974	0.996	878	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	ID=COSV54469893;OCCURENCE=1(biliary_tract)	FBN3	143	0	183	75	0.290697674418605	TRUE	TRUE
ENSG00000177599.13	.	BCM	GRCh38.p13	chr19	11806095	11806095	+	G	G	A	Missense_Mutation	SNP	ENST00000323169.10	exon3	c.G142A	p.G48R	exonic	ENSG00000177599.13	.	nonsynonymous SNV	ENSG00000177599.13:ENST00000323169.10:exon3:c.G142A:p.G48R	19p13.2	C3L-02604	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	.	N	N	T	D	0.082	T	T	T	0.040	.	0.030	0.024	T	T	T	T	T	T	-0.592	0.076	0.946	N	N	-1.724	0.033	-1.793	0.035	0.000	0.554	0.588	0.602	0.621	.	1.010	-1.780	-4.884	-1.275	-0.181	0.000	0.000	0.000	934	Zinc_finger_C2H2-type	.	.	.	ZNF491	188	0	162	65	0.286343612334802	TRUE	TRUE
ENSG00000105695.15	.	BCM	GRCh38.p13	chr19	35310030	35310030	+	C	C	A	Nonsense_Mutation	SNP	ENST00000392213.8	exon8	c.C1388A	p.S463X	exonic	ENSG00000105695.15	.	stopgain	ENSG00000105695.15:ENST00000392213.8:exon8:c.C1388A:p.S463X	19q13.12	C3L-02604	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.779	.	.	.	.	.	.	.	.	.	D	D	.	.	7.841	39	0.996	D	N	0.773	8.284	0.637	6.722	1.000	0.554	0.588	0.576	0.613	.	4.800	4.800	3.659	1.026	0.599	0.991	0.954	0.811	923	.	.	.	.	MAG	332	0	417	175	0.295608108108108	TRUE	TRUE
ENSG00000105675.9	.	BCM	GRCh38.p13	chr19	35557766	35557766	+	G	G	A	Missense_Mutation	SNP	ENST00000262623.4	exon11	c.C1582T	p.R528C	exonic	ENSG00000105675.9	.	nonsynonymous SNV	ENSG00000105675.9:ENST00000262623.4:exon11:c.C1582T:p.R528C	19q13.12	C3L-02604	.	.	.	.	.	.	.	.	.	18.20	D	T	D	D	D	D	M	T	D	0.927	D	D	D	0.801	0.655	0.929	2.128	D	D	D	D	D	D	4.735	32	0.999	D	D	0.608	6.006	0.503	5.190	1.000	0.659	0.689	0.240	0.604	.	3.800	2.690	3.646	1.164	0.604	1.000	1.000	0.999	799	.	.	.	.	ATP4A	146	0	259	57	0.180379746835443	TRUE	NA
ENSG00000090006.18	.	BCM	GRCh38.p13	chr19	40611251	40611251	+	G	G	A	Missense_Mutation	SNP	ENST00000308370.11	exon16	c.G2111A	p.G704D	exonic	ENSG00000090006.18	.	nonsynonymous SNV	ENSG00000090006.18:ENST00000308370.11:exon16:c.G2111A:p.G704D	19q13.2	C3L-02604	.	.	.	.	.	.	.	.	.	17.20	D	T	D	D	D	D	H	D	D	0.764	D	D	D	0.777	0.811	0.765	1.273	T	D	D	D	D	D	3.471	24.600	0.998	D	N	0.555	5.493	0.433	4.598	1.000	0.741	0.634	0.000	0.563	.	4.810	3.760	0.605	1.176	0.676	0.012	0.999	0.998	749	EGF-like,_conserved_site;EGF-like_domain;EGF-like_calcium-binding_domain	.	.	.	LTBP4	370	1	556	183	0.247631935047361	TRUE	TRUE
ENSG00000087510.7	.	BCM	GRCh38.p13	chr20	56631259	56631259	+	G	G	A	Missense_Mutation	SNP	ENST00000201031.3	exon2	c.G103A	p.A35T	exonic	ENSG00000087510.7	.	nonsynonymous SNV	ENSG00000087510.7:ENST00000201031.3:exon2:c.G103A:p.A35T	20q13.31	C3L-02604	8.68e-06	0	0	0	0.0002	0	0	0	rs775607231	5.20	D	T	B	B	D	D	L	T	N	0.152	T	T	D	0.213	0.162	0.590	0.905	T	T	T	T	T	T	2.044	19.590	0.989	D	N	-0.618	0.955	-0.579	1.078	1.000	0.726	0.563	0.594	0.639	.	5.670	1.470	3.687	0.110	0.575	0.995	0.035	0.667	976	.	.	.	ID=COSV104389725;OCCURENCE=1(large_intestine)	TFAP2C	45	0	62	15	0.194805194805195	TRUE	NA
ENSG00000156282.5	.	BCM	GRCh38.p13	chr21	30166436	30166436	+	C	C	T	Missense_Mutation	SNP	ENST00000286808.5	exon1	c.G182A	p.R61Q	exonic	ENSG00000156282.5	.	nonsynonymous SNV	ENSG00000156282.5:ENST00000286808.5:exon1:c.G182A:p.R61Q	21q21.3	C3L-02604	8.249e-06	0	0	0	0	1.501e-05	0	0	rs773823219	4.20	T	T	P	B	D	N	N	D	N	0.123	T	T	D	0.310	0.506	0.719	0.075	T	T	T	T	T	D	1.777	17.560	0.491	N	N	-0.729	0.764	-0.739	0.844	0.917	0.487	0.574	0.574	0.564	.	5.220	2.250	0.507	0.087	0.599	0.071	0.143	0.972	565	Claudin,_conserved_site	.	.	ID=COSV54522581;OCCURENCE=1(stomach)	CLDN17	194	0	273	85	0.237430167597765	TRUE	TRUE
ENSG00000244486.9	.	BCM	GRCh38.p13	chr22	20431966	20431966	+	C	C	T	Missense_Mutation	SNP	ENST00000623402.1	exon2	c.G196A	p.A66T	exonic	ENSG00000244486.9	.	nonsynonymous SNV	ENSG00000244486.9:ENST00000623402.1:exon2:c.G196A:p.A66T	22q11.21	C3L-02604	.	.	.	.	.	.	.	.	.	0.17	.	T	B	B	N	N	N	.	.	0.094	T	T	T	0.020	0.414	0.132	.	T	T	T	T	T	T	0.558	7.095	0.972	N	N	-0.575	1.034	-0.561	1.106	1.000	0.696	0.610	0.654	0.563	.	4.530	-0.482	-3.023	0.943	0.545	0.000	0.985	0.775	982	.	.	.	ID=COSV56733297;OCCURENCE=1(large_intestine)	SCARF2	560	2	516	254	0.32987012987013	TRUE	TRUE
ENSG00000099949.21	.	BCM	GRCh38.p13	chr22	20987536	20987536	+	G	G	A	Missense_Mutation	SNP	ENST00000646124.2	exon4	c.G353A	p.R118H	exonic	ENSG00000099949.21	.	nonsynonymous SNV	ENSG00000099949.21:ENST00000646124.2:exon4:c.G353A:p.R118H	22q11.21	C3L-02604	2.485e-05	0	0	0	0	1.51e-05	0	0.0001	rs769001939	18.20	D	D	D	D	D	D	H	T	D	0.945	D	D	D	0.830	0.901	0.891	1.885	D	T	D	D	D	D	4.204	28.700	1.000	D	D	1.040	15.223	0.954	16.251	1.000	0.706	0.654	0.710	0.711	.	5.280	5.280	7.638	1.172	0.672	1.000	0.984	0.786	923	.	.	.	ID=COSV53145056;OCCURENCE=1(central_nervous_system)	LZTR1	188	0	197	88	0.308771929824561	TRUE	TRUE
ENSG00000159307.19	.	BCM	GRCh38.p13	chr22	43210123	43210123	+	C	C	A	Missense_Mutation	SNP	ENST00000360835.9	exon19	c.G2501T	p.R834L	exonic	ENSG00000159307.19	.	nonsynonymous SNV	ENSG00000159307.19:ENST00000360835.9:exon19:c.G2501T:p.R834L	22q13.2	C3L-02604	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	L	T	D	0.864	T	T	D	0.591	0.629	0.687	1.828	D	T	D	D	D	D	4.059	27.400	0.998	D	D	0.595	5.871	0.543	5.573	1.000	0.646	0.590	0.645	0.568	.	3.630	3.630	7.831	1.026	0.599	1.000	0.994	0.865	691	CUB_domain	.	.	.	SCUBE1	59	0	81	25	0.235849056603774	TRUE	TRUE
ENSG00000169891.18	.	BCM	GRCh38.p13	chrX	17062532	17062532	+	-	NA	GTAA	Frame_Shift_Ins	INS	ENST00000357277.8	exon9	c.1209_1210insGTAA	p.K404Vfs*6	exonic	ENSG00000169891.18	.	frameshift insertion	ENSG00000169891.18:ENST00000357277.8:exon9:c.1209_1210insGTAA:p.K404Vfs*6	Xp22.2	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	REPS2	NA	NA	NA	NA	NA	NA	NA
ENSG00000158352.15	.	BCM	GRCh38.p13	chrX	50608178	50608178	+	C	C	A	Missense_Mutation	SNP	ENST00000376020.6	exon6	c.G2964T	p.M988I	exonic	ENSG00000158352.15	.	nonsynonymous SNV	ENSG00000158352.15:ENST00000376020.6:exon6:c.G2964T:p.M988I	Xp11.22	C3L-02604	.	.	.	.	.	.	.	.	.	2.19	T	T	B	B	N	N	L	T	N	0.174	T	T	D	0.075	0.188	0.151	0.116	T	T	T	T	T	T	1.105	12.820	0.939	D	.	.	.	.	.	0.976	.	.	.	.	.	5.640	2.860	0.183	1.026	0.599	0.938	0.999	0.983	799	.	.	.	ID=COSV56795761;OCCURENCE=1(lung)	SHROOM4	281	1	382	108	0.220408163265306	TRUE	TRUE
ENSG00000126733.21	.	BCM	GRCh38.p13	chrX	86695179	86695179	+	A	A	T	Nonsense_Mutation	SNP	ENST00000373125.9	exon5	c.A931T	p.R311X	exonic	ENSG00000126733.21	.	stopgain	ENSG00000126733.21:ENST00000373125.9:exon5:c.A931T:p.R311X	Xq21.2	C3L-02604	.	.	.	.	.	.	.	.	.	5.5	.	.	.	.	D	A	.	.	.	0.978	.	.	.	.	.	.	.	.	.	D	D	.	.	6.895	36	0.997	D	.	.	.	.	.	0.000	.	.	.	.	.	4.990	3.800	3.376	0.104	0.663	1.000	0.968	0.969	937	.	.	.	.	DACH2	18	0	23	7	0.233333333333333	NA	TRUE
ENSG00000171054.8	.	BCM	GRCh38.p13	chrX	131544948	131544948	+	-	NA	A	Frame_Shift_Ins	INS	ENST00000338616.5	exon1	c.876dupA	p.D295Rfs*3	exonic	ENSG00000171054.8	.	frameshift insertion	ENSG00000171054.8:ENST00000338616.5:exon1:c.876dupA:p.D295Rfs*3	Xq26.2	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR13H1	NA	NA	NA	NA	NA	NA	NA
ENSG00000004487.17	.	BCM	GRCh38.p13	chr1	23083310	23083310	+	G	G	A	Silent	SNP	ENST00000356634.7	exon19	c.G2505A	p.T835T	exonic	ENSG00000004487.17	.	synonymous SNV	ENSG00000004487.17:ENST00000356634.7:exon19:c.G2505A:p.T835T	1p36.12	C3L-02604	0.0010	0.0107	0.0004	0	0	0.0001	0	0	rs150794224	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56500797;OCCURENCE=1(stomach),1(urinary_tract)	KDM1A	124	1	187	58	0.236734693877551	TRUE	TRUE
ENSG00000136630.13	.	BCM	GRCh38.p13	chr1	220884317	220884317	+	C	C	T	Silent	SNP	ENST00000366903.8	exon4	c.C1080T	p.G360G	exonic	ENSG00000136630.13	.	synonymous SNV	ENSG00000136630.13:ENST00000366903.8:exon4:c.C1080T:p.G360G	1q41	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HLX	151	0	211	87	0.291946308724832	TRUE	TRUE
ENSG00000115414.20	.	BCM	GRCh38.p13	chr2	215397741	215397741	+	G	G	A	Silent	SNP	ENST00000354785.10	exon22	c.C3456T	p.T1152T	exonic	ENSG00000115414.20	.	synonymous SNV	ENSG00000115414.20:ENST00000354785.10:exon22:c.C3456T:p.T1152T	2q35	C3L-02604	8.239e-06	0	0	0	0	0	0.0011	0	rs762269962	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FN1	323	0	453	145	0.24247491638796	TRUE	NA
ENSG00000063660.9	.	BCM	GRCh38.p13	chr2	240462213	240462213	+	C	C	T	Silent	SNP	ENST00000264039.7	exon3	c.C348T	p.N116N	exonic	ENSG00000063660.9	.	synonymous SNV	ENSG00000063660.9:ENST00000264039.7:exon3:c.C348T:p.N116N	2q37.3	C3L-02604	5.45e-05	0	0	0	0	7.625e-05	0	9.649e-05	rs374492921	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV50867247;OCCURENCE=1(large_intestine),1(endometrium)	GPC1	66	0	79	30	0.275229357798165	TRUE	TRUE
ENSG00000133256.12	.	BCM	GRCh38.p13	chr4	625932	625932	+	C	C	T	Silent	SNP	ENST00000496514.5	exon1	c.C306T	p.G102G	exonic	ENSG00000133256.12	.	synonymous SNV	ENSG00000133256.12:ENST00000496514.5:exon1:c.C306T:p.G102G	4p16.3	C3L-02604	7.699e-05	0.0002	0.0003	0.0003	0	3.604e-05	0	0	rs201939549	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55328837;OCCURENCE=1(oesophagus),1(biliary_tract)	PDE6B	124	0	206	61	0.228464419475655	TRUE	TRUE
ENSG00000261934.2	.	BCM	GRCh38.p13	chr5	141404806	141404806	+	G	G	A	Silent	SNP	ENST00000573521.1	exon1	c.G1854A	p.S618S	exonic	ENSG00000261934.2	.	synonymous SNV	ENSG00000261934.2:ENST00000573521.1:exon1:c.G1854A:p.S618S	5q31.3	C3L-02604	2.485e-05	0	0	0.0003	0	0	0	0	rs774487660	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PCDHGA9	401	1	559	183	0.246630727762803	TRUE	NA
ENSG00000120278.16	.	BCM	GRCh38.p13	chr6	150831496	150831496	+	C	C	T	Silent	SNP	ENST00000358517.6	exon15	c.C2385T	p.D795D	exonic	ENSG00000120278.16	.	synonymous SNV	ENSG00000120278.16:ENST00000358517.6:exon15:c.C2385T:p.D795D	6q25.1	C3L-02604	.	.	.	.	.	.	.	.	rs140164486	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEKHG1	151	0	223	86	0.27831715210356	TRUE	NA
ENSG00000146555.19	.	BCM	GRCh38.p13	chr7	4114045	4114045	+	G	G	A	Silent	SNP	ENST00000404826.7	exon25	c.G3594A	p.P1198P	exonic	ENSG00000146555.19	.	synonymous SNV	ENSG00000146555.19:ENST00000404826.7:exon25:c.G3594A:p.P1198P	7p22.2	C3L-02604	1.654e-05	0	0	0	0	0	0	0.0001	rs775204533	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV101269355;OCCURENCE=1(stomach),1(skin)	SDK1	234	0	326	124	0.275555555555556	TRUE	NA
ENSG00000003989.18	.	BCM	GRCh38.p13	chr8	17551876	17551876	+	G	G	A	Silent	SNP	ENST00000494857.6	exon7	c.G945A	p.P315P	exonic	ENSG00000003989.18	.	synonymous SNV	ENSG00000003989.18:ENST00000494857.6:exon7:c.G945A:p.P315P	8p22	C3L-02604	5.766e-05	0.0002	0	0	0	0	0	0.0003	rs141741899	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99136558;OCCURENCE=1(stomach)	SLC7A2	495	0	641	209	0.245882352941176	TRUE	NA
ENSG00000177354.12	.	BCM	GRCh38.p13	chr10	49323433	49323433	+	C	C	T	Silent	SNP	ENST00000374144.8	exon3	c.C888T	p.T296T	exonic	ENSG00000177354.12	.	synonymous SNV	ENSG00000177354.12:ENST00000374144.8:exon3:c.C888T:p.T296T	10q11.23	C3L-02604	1.663e-05	0	0	0.0001	0	1.505e-05	0	0	rs372950100	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60508142;OCCURENCE=1(stomach),1(skin)	C10orf71	142	0	191	64	0.250980392156863	TRUE	TRUE
ENSG00000099204.20	.	BCM	GRCh38.p13	chr10	114601828	114601828	+	T	T	C	Silent	SNP	ENST00000277895.9	exon2	c.A378G	p.K126K	exonic	ENSG00000099204.20	.	synonymous SNV	ENSG00000099204.20:ENST00000277895.9:exon2:c.A378G:p.K126K	10q25.3	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABLIM1	462	0	960	256	0.210526315789474	TRUE	TRUE
ENSG00000175029.17	.	BCM	GRCh38.p13	chr10	124998088	124998088	+	C	C	A	Silent	SNP	ENST00000337195.9	exon6	c.G441T	p.R147R	exonic	ENSG00000175029.17	.	synonymous SNV	ENSG00000175029.17:ENST00000337195.9:exon6:c.G441T:p.R147R	10q26.13	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CTBP2	378	0	747	168	0.183606557377049	TRUE	TRUE
ENSG00000184154.14	.	BCM	GRCh38.p13	chr11	72106041	72106041	+	G	G	A	Silent	SNP	ENST00000541899.2	exon1	c.G90A	p.T30T	exonic	ENSG00000184154.14;ENSG00000284844.1	.	synonymous SNV	ENSG00000284844.1:ENST00000541899.2:exon1:c.G90A:p.T30T,ENSG00000184154.14:ENST00000307198.11:exon5:c.G189A:p.T63T	11q13.4	C3L-02604	5.07e-05	0	0	0.0016	0	0	0	0	rs556093010	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53825266;OCCURENCE=1(endometrium)	LRTOMT	184	0	292	89	0.233595800524934	TRUE	TRUE
ENSG00000088808.18	.	BCM	GRCh38.p13	chr14	103741872	103741872	+	G	G	A	Silent	SNP	ENST00000202556.14	exon11	c.C1740T	p.Y580Y	exonic	ENSG00000088808.18	.	synonymous SNV	ENSG00000088808.18:ENST00000202556.14:exon11:c.C1740T:p.Y580Y	14q32.33	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPP1R13B	264	0	351	120	0.254777070063694	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11854293	11854293	+	C	C	T	Silent	SNP	ENST00000262442.9	exon50	c.C9798T	p.C3266C	exonic	ENSG00000007174.18	.	synonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon50:c.C9798T:p.C3266C	17p12	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH9	334	0	349	136	0.280412371134021	TRUE	TRUE
ENSG00000153976.3	.	BCM	GRCh38.p13	chr17	13600593	13600593	+	G	G	A	Silent	SNP	ENST00000284110.2	exon1	c.C537T	p.R179R	exonic	ENSG00000153976.3	.	synonymous SNV	ENSG00000153976.3:ENST00000284110.2:exon1:c.C537T:p.R179R	17p12	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99404235;OCCURENCE=1(large_intestine)	HS3ST3A1	326	0	338	160	0.321285140562249	TRUE	TRUE
ENSG00000125319.14	.	BCM	GRCh38.p13	chr17	44148334	44148334	+	A	A	T	Silent	SNP	ENST00000319977.8	exon3	c.A531T	p.G177G	exonic	ENSG00000125319.14	.	synonymous SNV	ENSG00000125319.14:ENST00000319977.8:exon3:c.A531T:p.G177G	17q21.31	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HROB	172	0	290	57	0.164265129682997	TRUE	TRUE
ENSG00000004939.15	.	BCM	GRCh38.p13	chr17	44255273	44255273	+	G	G	A	Silent	SNP	ENST00000262418.12	exon15	c.C1824T	p.F608F	exonic	ENSG00000004939.15	.	synonymous SNV	ENSG00000004939.15:ENST00000262418.12:exon15:c.C1824T:p.F608F	17q21.31	C3L-02604	4.652e-05	0	0	0	0	0.0001	0	0	rs751967295	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99292966;OCCURENCE=1(cervix)	SLC4A1	138	0	218	69	0.240418118466899	TRUE	NA
ENSG00000196090.12	.	BCM	GRCh38.p13	chr20	42115274	42115274	+	G	G	A	Silent	SNP	ENST00000373187.5	exon22	c.C3024T	p.Y1008Y	exonic	ENSG00000196090.12	.	synonymous SNV	ENSG00000196090.12:ENST00000373187.5:exon22:c.C3024T:p.Y1008Y	20q12	C3L-02604	6.628e-05	0.0002	8.64e-05	0	0	7.496e-05	0	0	rs369837092	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61957752;OCCURENCE=3(oesophagus)	PTPRT	230	0	345	88	0.203233256351039	TRUE	TRUE
ENSG00000054796.13	.	BCM	GRCh38.p13	chr20	57333239	57333239	+	G	G	A	Silent	SNP	ENST00000371263.8	exon3	c.G297A	p.K99K	exonic	ENSG00000054796.13	.	synonymous SNV	ENSG00000054796.13:ENST00000371263.8:exon3:c.G297A:p.K99K	20q13.31	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPO11	171	0	239	61	0.203333333333333	TRUE	TRUE
ENSG00000130702.15	.	BCM	GRCh38.p13	chr20	62318580	62318580	+	G	G	A	Silent	SNP	ENST00000252999.7	exon53	c.C7113T	p.R2371R	exonic	ENSG00000130702.15	.	synonymous SNV	ENSG00000130702.15:ENST00000252999.7:exon53:c.C7113T:p.R2371R	20q13.33	C3L-02604	9.3e-05	0	0.0003	0	0	9.291e-05	0	6.067e-05	rs111275179	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99442975;OCCURENCE=2(large_intestine)	LAMA5	279	0	449	149	0.249163879598662	TRUE	NA
ENSG00000234469.4	.	BCM	GRCh38.p13	chrX	9967438	9967438	+	G	G	A	Silent	SNP	ENST00000445307.4	exon1	c.G81A	p.T27T	exonic	ENSG00000234469.4	.	synonymous SNV	ENSG00000234469.4:ENST00000445307.4:exon1:c.G81A:p.T27T	Xp22.2	C3L-02604	.	.	.	.	.	.	.	.	rs1035174605	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLDN34	198	0	304	87	0.222506393861893	TRUE	NA
ENSG00000180815.14	.	BCM	GRCh38.p13	chrX	19398306	19398306	+	C	C	T	Silent	SNP	ENST00000338883.8	exon15	c.G1986A	p.T662T	exonic	ENSG00000180815.14	.	synonymous SNV	ENSG00000180815.14:ENST00000338883.8:exon15:c.G1986A:p.T662T	Xp22.12	C3L-02604	6.838e-05	0	0	0	0	0	0	0.0006	rs757580712	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP3K15	286	2	445	107	0.193840579710145	TRUE	NA
ENSG00000116473.14	.	BCM	GRCh38.p13	chr1	111703333	111703333	+	-	NA	AGG	Intron	INS	NA	NA	NA	NA	intronic	ENSG00000116473.14	.	.	.	1p13.2	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RAP1A	NA	NA	NA	NA	NA	NA	NA
ENSG00000274702.1	.	BCM	GRCh38.p13	chr1	187641480	187641480	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000274702.1;ENSG00000236401.1	dist=9041;dist=65081	.	.	1q31.1	C3L-02604	5.667e-05	0	0	0	0	0	0	0.0001	rs764508334	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AL357559.1	136	0	202	68	0.251851851851852	TRUE	NA
ENSG00000116962.15	.	BCM	GRCh38.p13	chr1	236064610	236064610	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000116962.15	.	.	.	1q42.3	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NID1	58	0	72	18	0.2	TRUE	NA
ENSG00000135636.14	.	BCM	GRCh38.p13	chr2	71620556	71620556	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000135636.14	.	.	.	2p13.2	C3L-02604	4.604e-05	0.0005	0	0	0	0	0	0	rs766512164	6.17	T	T	D	P	.	D	.	D	N	0.666	T	T	D	0.360	.	0.777	0.193	T	.	T	T	T	T	2.497	22.400	0.997	D	D	0.017	2.573	0.161	2.998	1.000	0.707	0.574	0.659	0.714	.	4.740	4.740	5.316	1.083	0.618	1.000	0.981	0.966	428	.	.	.	.	DYSF	217	0	346	88	0.202764976958525	TRUE	NA
ENSG00000163602.10	.	BCM	GRCh38.p13	chr3	72446646	72446646	+	A	A	-	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000163602.10	dist=25	.	.	3p13	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RYBP	291	0	374	140	0.272373540856031	TRUE	TRUE
ENSG00000287916.1	.	BCM	GRCh38.p13	chr3	156291951	156291951	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000287916.1	.	.	.	3q25.31	C3L-02604	.	.	.	.	.	.	.	.	.	8.18	D	T	D	P	D	D	.	T	N	0.445	T	T	T	0.207	0.450	0.429	.	.	T	T	T	D	D	2.376	22.000	0.999	D	D	0.669	6.712	0.686	7.503	1.000	0.437	0.563	0.607	0.604	.	5.040	5.040	9.745	1.176	0.618	1.000	1.000	0.999	791	.	.	.	.	AC091607.2	384	0	571	184	0.243708609271523	TRUE	TRUE
ENSG00000197226.12	.	BCM	GRCh38.p13	chr5	179862581	179862581	+	C	C	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000197226.12	ENST00000356834.7:c.*867G>T	.	.	5q35.3	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBC1D9B	151	0	314	117	0.271461716937355	TRUE	TRUE
ENSG00000215244.3	.	BCM	GRCh38.p13	chr10	6328184	6328184	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000215244.3	.	.	.	10p15.1	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC02649	183	0	389	97	0.199588477366255	TRUE	NA
ENSG00000187185.4	.	BCM	GRCh38.p13	chr16	57816735	57816735	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000187185.4	.	.	.	16q21	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC092118.1	207	0	300	98	0.246231155778894	TRUE	NA
ENSG00000267757.4	.	BCM	GRCh38.p13	chr19	45645273	45645273	+	C	C	T	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000267757.4;ENSG00000241226.3	dist=2433;dist=6237	.	.	19q13.32	C3L-02604	.	.	.	.	.	.	.	.	.	7.13	.	D	.	.	.	D	.	T	.	0.311	T	T	D	0.157	.	0.691	0.683	D	.	T	T	D	T	5.806	35	0.961	D	D	0.383	4.239	0.412	4.443	1.000	0.455	0.547	0.607	0.563	.	4.390	4.390	4.998	1.025	0.596	1.000	1.000	0.995	770	.	.	.	.	EML2-AS1	229	1	361	69	0.16046511627907	TRUE	TRUE
ENSG00000101203.16	.	BCM	GRCh38.p13	chr20	63325271	63325271	+	A	A	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000101203.16	.	.	.	20q13.33	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	COL20A1	251	0	386	105	0.213849287169043	TRUE	NA
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140903039	140903040	+	TC	TC	CA	Unknown	MNP	ENST00000389484.8	exon23	c.3646_3647delinsTG	p.D1216C	exonic	ENSG00000168702.18	.	nonframeshift substitution	ENSG00000168702.18:ENST00000389484.8:exon23:c.3646_3647delinsTG:p.D1216C	2q22.1	C3L-02604	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRP1B	216	1	354	78	0.180555555555556	TRUE	TRUE
ENSG00000065526.12	.	BCM	GRCh38.p13	chr1	15929695	15929695	+	C	C	A	Nonsense_Mutation	SNP	ENST00000375759.8	exon11	c.C3455A	p.S1152X	exonic	ENSG00000065526.12	.	stopgain	ENSG00000065526.12:ENST00000375759.8:exon11:c.C3455A:p.S1152X	1p36.13	C3L-00277	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	A	.	.	.	0.788	.	.	.	.	.	.	.	.	.	D	D	.	.	5.872	35	0.996	N	N	0.406	4.379	0.198	3.172	0.011	0.707	0.725	0.725	0.714	.	5.200	3.290	1.126	0.088	0.599	0.028	0.984	1.000	419	.	.	.	.	SPEN	128	0	121	54	0.308571428571429	TRUE	TRUE
ENSG00000162692.12	.	BCM	GRCh38.p13	chr1	100732632	100732632	+	A	A	C	Missense_Mutation	SNP	ENST00000294728.7	exon7	c.A1740C	p.E580D	exonic	ENSG00000162692.12	.	nonsynonymous SNV	ENSG00000162692.12:ENST00000294728.7:exon7:c.A1740C:p.E580D	1p21.2	C3L-00277	.	.	.	.	.	.	.	.	.	7.20	D	D	B	B	N	D	M	T	N	0.340	T	T	T	0.141	0.650	0.390	0.236	T	T	T	T	D	T	1.559	16.110	0.995	D	D	-0.135	2.068	-0.154	1.900	0.112	0.554	0.602	0.574	0.621	.	5.570	3.230	1.814	-0.076	-0.828	1.000	0.998	0.620	427	Immunoglobulin_subtype_2;Immunoglobulin_V-set_domain;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	VCAM1	78	0	95	39	0.291044776119403	TRUE	NA
ENSG00000116584.20	.	BCM	GRCh38.p13	chr1	155951050	155951050	+	G	G	A	Missense_Mutation	SNP	ENST00000361247.9	exon20	c.C2482T	p.R828W	exonic	ENSG00000116584.20	.	nonsynonymous SNV	ENSG00000116584.20:ENST00000361247.9:exon20:c.C2482T:p.R828W	1q22	C3L-00277	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	N	N	T	D	0.443	T	T	D	0.134	.	0.545	1.282	D	T	T	T	D	D	3.336	24.200	0.999	D	N	0.401	4.347	0.417	4.484	0.999	0.672	0.702	0.702	0.636	.	5.120	5.120	0.602	1.176	0.676	0.000	0.160	0.882	111	.	.	.	.	ARHGEF2	201	0	606	94	0.134285714285714	TRUE	NA
ENSG00000198400.11	.	BCM	GRCh38.p13	chr1	156864747	156864747	+	C	C	T	Missense_Mutation	SNP	ENST00000524377.5	exon3	c.C307T	p.L103F	exonic	ENSG00000198400.11	.	nonsynonymous SNV	ENSG00000198400.11:ENST00000524377.5:exon3:c.C307T:p.L103F	1q23.1	C3L-00277	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	N	0.774	T	T	D	0.617	0.565	0.921	0.923	T	T	D	D	D	T	3.999	27.000	0.999	D	D	0.693	7.023	0.648	6.885	1.000	0.598	0.547	0.596	0.550	.	5.140	5.140	3.614	1.026	0.549	0.997	0.990	0.993	623	.	.	.	.	NTRK1	249	0	486	408	0.456375838926175	TRUE	TRUE
ENSG00000162735.18	.	BCM	GRCh38.p13	chr1	160282074	160282074	+	C	C	A	Missense_Mutation	SNP	ENST00000485079.1	exon2	c.G169T	p.V57L	exonic	ENSG00000162735.18;ENSG00000258465.8	.	nonsynonymous SNV	ENSG00000258465.8:ENST00000485079.1:exon2:c.G169T:p.V57L,ENSG00000162735.18:ENST00000368072.9:exon5:c.G559T:p.V187L	1q23.2	C3L-00277	.	.	.	.	.	.	.	.	.	10.19	D	T	P	B	D	D	L	T	N	0.532	T	T	D	0.278	0.695	0.509	0.288	.	T	D	D	D	D	2.767	23.000	0.997	D	D	0.173	3.187	0.325	3.867	1.000	0.722	0.725	0.699	0.714	.	5.080	5.080	5.349	1.026	0.599	1.000	1.000	0.986	300	.	.	.	.	PEX19	298	0	670	79	0.105473965287049	TRUE	TRUE
ENSG00000143512.13	.	BCM	GRCh38.p13	chr1	222532110	222532110	+	G	G	A	Nonsense_Mutation	SNP	ENST00000343410.7	exon6	c.C1579T	p.R527X	exonic	ENSG00000143512.13	.	stopgain	ENSG00000143512.13:ENST00000343410.7:exon6:c.C1579T:p.R527X	1q41	C3L-00277	1.711e-05	0	0	0	0	3.099e-05	0	0	rs779253171	6.6	.	.	.	.	D	A	.	.	.	0.417	.	.	.	.	.	.	.	.	.	D	D	.	.	9.137	47	0.999	D	D	0.758	8.012	0.608	6.329	0.558	0.487	0.574	0.574	0.564	.	5.000	4.090	5.495	1.122	0.595	1.000	1.000	0.996	913	Glucose/Sorbosone_dehydrogenase	.	.	ID=COSV58567693;OCCURENCE=1(central_nervous_system)	HHIPL2	79	0	163	26	0.137566137566138	TRUE	TRUE
ENSG00000003137.8	.	BCM	GRCh38.p13	chr2	72133100	72133100	+	C	C	T	Missense_Mutation	SNP	ENST00000001146.6	exon5	c.G1069A	p.V357I	exonic	ENSG00000003137.8	.	nonsynonymous SNV	ENSG00000003137.8:ENST00000001146.6:exon5:c.G1069A:p.V357I	2p13.2	C3L-00277	3.382e-05	0.0002	0	0	0	1.55e-05	0	6.089e-05	rs541205721	9.20	D	D	D	D	N	D	M	T	N	0.268	T	T	D	0.402	0.831	0.645	0.694	T	T	T	T	T	D	2.946	23.300	0.999	D	N	0.614	6.065	0.584	6.032	1.000	0.516	0.574	0.604	0.586	.	5.640	4.760	4.884	1.026	0.599	1.000	0.976	0.960	920	.	.	.	ID=COSV50014098;OCCURENCE=1(lung)	CYP26B1	452	1	569	137	0.194050991501416	TRUE	TRUE
ENSG00000115598.10	.	BCM	GRCh38.p13	chr2	102239237	102239237	+	G	G	C	Missense_Mutation	SNP	ENST00000264257.7	exon12	c.G1724C	p.G575A	exonic	ENSG00000115598.10	.	nonsynonymous SNV	ENSG00000115598.10:ENST00000264257.7:exon12:c.G1724C:p.G575A	2q12.1	C3L-00277	.	.	.	.	.	.	.	.	.	2.19	D	D	B	B	.	N	N	T	N	0.132	T	T	T	0.022	0.191	0.048	0.160	T	T	T	T	T	T	-0.131	0.715	0.939	N	N	-1.352	0.138	-1.407	0.148	1.000	0.616	0.575	0.547	0.632	.	2.290	0.318	-1.014	-0.522	-0.891	0.000	0.002	0.003	834	.	.	.	.	IL1RL2	169	0	196	41	0.172995780590717	TRUE	TRUE
ENSG00000144460.12	.	BCM	GRCh38.p13	chr2	225651486	225651486	+	C	C	T	Missense_Mutation	SNP	ENST00000636099.1	exon7	c.C1883T	p.P628L	exonic	ENSG00000144460.12	.	nonsynonymous SNV	ENSG00000144460.12:ENST00000636099.1:exon7:c.C1883T:p.P628L	2q36.3	C3L-00277	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	N	D	M	T	N	0.563	T	T	T	0.290	0.091	0.103	1.101	T	T	T	T	D	D	3.754	25.600	0.999	D	D	0.578	5.709	0.614	6.402	1.000	0.487	0.563	0.547	0.564	.	5.720	5.720	5.752	1.026	0.599	1.000	0.946	0.815	608	Neuronal_tyrosine-phosphorylated_phosphoinositide-3-kinase_adapter,_C-terminal_domain	.	.	.	NYAP2	295	0	439	90	0.170132325141777	TRUE	TRUE
ENSG00000126524.10	.	BCM	GRCh38.p13	chr7	66988402	66988402	+	T	T	A	Missense_Mutation	SNP	ENST00000246868.7	exon5	c.A722T	p.D241V	exonic	ENSG00000126524.10	.	nonsynonymous SNV	ENSG00000126524.10:ENST00000246868.7:exon5:c.A722T:p.D241V	7q11.21	C3L-00277	.	.	.	.	.	.	.	.	.	13.20	T	T	B	B	D	D	L	D	D	0.808	D	D	D	0.627	0.273	0.957	0.650	T	T	D	D	D	D	2.660	22.800	0.957	D	D	-0.210	1.848	-0.022	2.285	0.502	0.707	0.725	0.725	0.714	.	5.050	3.880	7.105	0.951	0.550	1.000	0.967	0.944	929	.	.	.	.	SBDS	298	0	361	227	0.386054421768707	NA	TRUE
ENSG00000128512.23	.	BCM	GRCh38.p13	chr7	111739238	111739238	+	G	G	T	Missense_Mutation	SNP	ENST00000437633.6	exon48	c.C5101A	p.P1701T	exonic	ENSG00000128512.23	.	nonsynonymous SNV	ENSG00000128512.23:ENST00000437633.6:exon48:c.C5101A:p.P1701T	7q31.1	C3L-00277	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	L	T	D	0.635	T	D	D	0.377	0.227	0.680	0.412	D	T	D	D	D	D	4.027	27.200	0.997	D	D	0.943	12.217	0.946	15.856	1.000	0.707	0.547	0.567	0.714	.	6.050	6.050	9.356	1.176	0.676	1.000	0.992	0.986	906	.	.	.	.	DOCK4	212	0	478	91	0.159929701230228	TRUE	TRUE
ENSG00000104626.15	.	BCM	GRCh38.p13	chr8	9007991	9007991	+	G	G	T	Missense_Mutation	SNP	ENST00000250263.8	exon2	c.G130T	p.D44Y	exonic	ENSG00000104626.15	.	nonsynonymous SNV	ENSG00000104626.15:ENST00000250263.8:exon2:c.G130T:p.D44Y	8p23.1	C3L-00277	.	.	.	.	.	.	.	.	.	7.20	D	D	B	B	N	D	M	T	D	0.284	T	T	T	0.103	0.256	0.403	0.033	T	T	T	T	D	T	2.889	23.200	0.994	D	N	-0.012	2.469	0.126	2.844	1.000	0.706	0.710	0.710	0.635	.	5.000	5.000	2.630	1.176	0.676	0.997	0.991	0.804	870	.	.	.	.	ERI1	136	0	245	13	0.0503875968992248	TRUE	NA
ENSG00000164736.6	.	BCM	GRCh38.p13	chr8	54459073	54459073	+	C	C	T	Missense_Mutation	SNP	ENST00000297316.5	exon2	c.C323T	p.A108V	exonic	ENSG00000164736.6	.	nonsynonymous SNV	ENSG00000164736.6:ENST00000297316.5:exon2:c.C323T:p.A108V	8q11.23	C3L-00277	.	.	.	.	.	.	.	.	rs931390946	17.20	D	D	D	D	D	D	L	D	D	0.249	D	D	D	0.731	0.472	0.682	1.891	T	D	D	D	D	T	4.157	28.300	0.999	D	D	0.546	5.414	0.502	5.176	1.000	0.437	0.563	0.607	0.562	.	4.030	4.030	4.856	0.940	0.501	1.000	0.990	0.995	905	High_mobility_group_box_domain	.	.	ID=COSV52024391;OCCURENCE=1(large_intestine),2(central_nervous_system)	SOX17	122	0	192	128	0.4	TRUE	TRUE
ENSG00000284609.1	.	BCM	GRCh38.p13	chr11	124396568	124396568	+	A	A	G	Missense_Mutation	SNP	ENST00000641139.1	exon2	c.T784C	p.Y262H	exonic	ENSG00000284609.1	.	nonsynonymous SNV	ENSG00000284609.1:ENST00000641139.1:exon2:c.T784C:p.Y262H	11q24.2	C3L-00277	.	.	.	.	.	.	.	.	.	2.20	D	D	B	B	N	N	N	T	N	0.220	T	T	T	0.019	0.616	0.168	0.710	T	T	T	T	T	T	1.063	12.380	0.919	N	N	-1.045	0.358	-1.032	0.450	0.000	0.487	0.574	0.547	0.564	.	3.760	1.450	-0.152	-0.241	0.641	0.000	0.006	0.975	861	GPCR,_rhodopsin-like,_7TM	.	.	.	OR8B3	147	0	215	71	0.248251748251748	NA	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227341	25227341	+	T	T	G	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A183C	p.Q61H	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A183C:p.Q61H	12p12.1	C3L-00277	.	.	.	.	.	.	.	.	rs17851045	17.20	D	D	B	B	D	D	M	D	D	0.760	D	D	D	0.644	0.659	0.905	1.857	D	D	D	D	D	T	2.993	23.400	0.997	D	D	0.298	3.768	0.383	4.239	0.998	0.722	0.710	0.710	0.735	.	5.770	5.770	2.812	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55498802;OCCURENCE=2(breast),6(liver),1(genital_tract),1(cervix),117(large_intestine),2(central_nervous_system),17(biliary_tract),3(ovary),8(stomach),50(haematopoietic_and_lymphoid_tissue),2(urinary_tract),1(kidney),71(pancreas),2(skin),2(prostate),28(lung),1(thyroid),2(small_intestine),5(endometrium)	KRAS	179	0	268	151	0.360381861575179	TRUE	TRUE
ENSG00000112787.13	.	BCM	GRCh38.p13	chr12	132583593	132583593	+	C	C	A	Missense_Mutation	SNP	ENST00000434748.2	exon17	c.C2953A	p.L985I	exonic	ENSG00000112787.13	.	nonsynonymous SNV	ENSG00000112787.13:ENST00000434748.2:exon17:c.C2953A:p.L985I	12q24.33	C3L-00277	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	U	N	L	T	N	0.054	T	T	D	0.015	0.218	0.014	.	D	T	T	T	T	T	1.048	12.210	0.979	N	N	-0.852	0.582	-0.839	0.703	0.999	0.658	0.588	0.619	0.563	.	3.150	0.605	1.606	0.615	0.373	0.995	0.508	0.252	769	.	.	.	.	FBRSL1	11	0	34	3	0.0810810810810811	TRUE	NA
ENSG00000185215.10	.	BCM	GRCh38.p13	chr14	103135235	103135235	+	G	G	A	Missense_Mutation	SNP	ENST00000560869.6	exon12	c.G1840A	p.A614T	exonic	ENSG00000185215.10	.	nonsynonymous SNV	ENSG00000185215.10:ENST00000560869.6:exon12:c.G1840A:p.A614T	14q32.32	C3L-00277	2.477e-05	0	8.643e-05	0	0	3.007e-05	0	0	rs368740303	11.20	D	D	D	D	D	D	M	T	D	0.226	T	T	D	0.268	.	0.538	0.964	T	T	T	T	D	T	3.711	25.500	0.999	D	N	0.416	4.443	0.337	3.937	1.000	0.707	0.702	0.723	0.714	.	4.600	3.710	2.204	1.083	0.674	0.994	0.996	0.920	636	.	.	.	ID=COSV60696133;OCCURENCE=1(stomach),1(endometrium)	TNFAIP2	287	0	489	219	0.309322033898305	TRUE	TRUE
ENSG00000006116.4	.	BCM	GRCh38.p13	chr16	24354949	24354949	+	G	G	A	Missense_Mutation	SNP	ENST00000005284.4	exon3	c.G412A	p.A138T	exonic	ENSG00000006116.4	.	nonsynonymous SNV	ENSG00000006116.4:ENST00000005284.4:exon3:c.G412A:p.A138T	16p12.1	C3L-00277	.	.	.	.	.	.	.	.	.	17.20	D	T	P	P	D	D	M	D	D	0.969	D	D	D	0.783	0.742	0.800	1.747	D	D	D	D	D	D	4.129	28.000	0.999	D	D	0.746	7.807	0.762	9.079	1.000	0.554	0.588	0.527	0.564	.	5.410	5.410	9.602	1.176	0.676	1.000	0.984	0.998	923	.	.	.	ID=COSV50064715;OCCURENCE=2(large_intestine),2(central_nervous_system),1(pancreas),1(lung)	CACNG3	163	0	231	67	0.224832214765101	TRUE	TRUE
ENSG00000140873.16	.	BCM	GRCh38.p13	chr16	77362123	77362123	+	C	C	T	Missense_Mutation	SNP	ENST00000282849.10	exon7	c.G1198A	p.E400K	exonic	ENSG00000140873.16	.	nonsynonymous SNV	ENSG00000140873.16:ENST00000282849.10:exon7:c.G1198A:p.E400K	16q23.1	C3L-00277	.	.	.	.	.	.	.	.	.	7.20	T	T	P	P	D	D	N	T	N	0.469	T	T	T	0.157	0.575	0.606	.	D	T	T	T	D	D	3.638	25.200	0.998	D	D	0.066	2.753	0.183	3.100	0.999	0.745	0.574	0.547	0.762	.	5.260	4.320	6.125	1.026	0.599	1.000	1.000	1.000	780	Peptidase_M12B,_ADAM/reprolysin	.	.	.	ADAMTS18	309	0	512	103	0.167479674796748	TRUE	NA
ENSG00000083290.20	.	BCM	GRCh38.p13	chr17	19804753	19804753	+	C	C	A	Missense_Mutation	SNP	ENST00000395544.9	exon15	c.G1235T	p.R412L	exonic	ENSG00000083290.20	.	nonsynonymous SNV	ENSG00000083290.20:ENST00000395544.9:exon15:c.G1235T:p.R412L	17p11.2	C3L-00277	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	L	T	D	0.701	D	D	D	0.567	0.476	0.939	0.643	T	D	D	T	D	D	3.828	26.000	0.999	D	D	0.759	8.030	0.726	8.260	1.000	0.732	0.588	0.659	0.728	.	5.160	5.160	5.446	1.006	0.575	1.000	1.000	0.998	501	.	.	.	.	ULK2	131	0	288	22	0.0709677419354839	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51065449	51065451	+	TAC	TAC	-	In_Frame_Del	DEL	ENST00000342988.8	exon9	c.982_984del	p.Y328del	exonic	ENSG00000141646.14	.	nonframeshift deletion	ENSG00000141646.14:ENST00000342988.8:exon9:c.982_984del:p.Y328del	18q21.2	C3L-00277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMAD4	330	0	268	106	0.283422459893048	TRUE	TRUE
ENSG00000181143.15	.	BCM	GRCh38.p13	chr19	8956509	8956509	+	T	T	C	Missense_Mutation	SNP	ENST00000397910.8	exon3	c.A20261G	p.D6754G	exonic	ENSG00000181143.15	.	nonsynonymous SNV	ENSG00000181143.15:ENST00000397910.8:exon3:c.A20261G:p.D6754G	19p13.2	C3L-00277	.	.	.	.	.	.	.	.	.	1.15	D	T	.	.	.	N	.	T	N	0.095	T	T	T	0.166	0.064	0.048	.	T	.	T	T	T	T	0.710	8.546	0.303	N	N	-1.028	0.374	-1.141	0.335	0.000	0.500	0.574	0.574	0.504	.	2.520	1.450	-0.433	0.022	-0.979	0.000	0.001	0.001	911	.	.	.	.	MUC16	122	0	200	48	0.193548387096774	TRUE	TRUE
ENSG00000089048.14	.	BCM	GRCh38.p13	chr20	13769995	13769995	+	T	T	C	Missense_Mutation	SNP	ENST00000202816.5	exon7	c.A1430G	p.D477G	exonic	ENSG00000089048.14	.	nonsynonymous SNV	ENSG00000089048.14:ENST00000202816.5:exon7:c.A1430G:p.D477G	20p12.1	C3L-00277	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	D	0.714	T	T	T	0.395	0.425	0.744	0.484	T	T	D	T	D	D	4.084	27.600	0.999	D	D	0.833	9.466	0.795	9.976	1.000	0.732	0.725	0.744	0.714	.	5.970	5.970	5.304	1.137	0.665	1.000	1.000	0.997	668	.	.	.	.	ESF1	181	0	183	104	0.362369337979094	TRUE	TRUE
ENSG00000102302.8	.	BCM	GRCh38.p13	chrX	54471401	54471401	+	G	G	A	Missense_Mutation	SNP	ENST00000375135.4	exon2	c.C394T	p.R132W	exonic	ENSG00000102302.8	.	nonsynonymous SNV	ENSG00000102302.8:ENST00000375135.4:exon2:c.C394T:p.R132W	Xp11.22	C3L-00277	1.149e-05	0	0	0.0002	0	0	0	0	rs746549256	1.19	T	D	B	B	N	N	N	T	N	0.122	T	T	T	0.148	0.316	0.192	0.294	T	T	T	T	T	T	1.399	15.070	0.874	N	.	.	.	.	.	1.000	.	.	.	.	.	4.880	-8.250	-0.121	-0.648	-0.746	0.988	0.656	0.847	62	.	.	.	ID=COSV100911078;OCCURENCE=1(stomach),1(endometrium)	FGD1	124	0	142	92	0.393162393162393	TRUE	NA
ENSG00000143450.17	.	BCM	GRCh38.p13	chr1	151766817	151766817	+	C	C	T	Silent	SNP	ENST00000400999.6	exon1	c.C96T	p.Y32Y	exonic	ENSG00000143450.17	.	synonymous SNV	ENSG00000143450.17:ENST00000400999.6:exon1:c.C96T:p.Y32Y	1q21.3	C3L-00277	6.106e-05	0	0	0	0	5.825e-05	0	0.0002	rs755800995	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OAZ3	326	0	748	90	0.107398568019093	TRUE	NA
ENSG00000160796.18	.	BCM	GRCh38.p13	chr3	47001132	47001132	+	G	G	C	Silent	SNP	ENST00000450053.8	exon28	c.G4437C	p.L1479L	exonic	ENSG00000160796.18	.	synonymous SNV	ENSG00000160796.18:ENST00000450053.8:exon28:c.G4437C:p.L1479L	3p21.31	C3L-00277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NBEAL2	104	0	169	50	0.228310502283105	TRUE	TRUE
ENSG00000176597.12	.	BCM	GRCh38.p13	chr3	183270005	183270005	+	G	G	A	Silent	SNP	ENST00000326505.4	exon2	c.G207A	p.A69A	exonic	ENSG00000176597.12	.	synonymous SNV	ENSG00000176597.12:ENST00000326505.4:exon2:c.G207A:p.A69A	3q27.1	C3L-00277	8.238e-06	0	0	0.0001	0	0	0	0	rs201133824	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	B3GNT5	175	0	230	125	0.352112676056338	TRUE	NA
ENSG00000113621.15	.	BCM	GRCh38.p13	chr5	134888053	134888053	+	G	G	A	Silent	SNP	ENST00000358387.9	exon2	c.G462A	p.A154A	exonic	ENSG00000113621.15	.	synonymous SNV	ENSG00000113621.15:ENST00000358387.9:exon2:c.G462A:p.A154A	5q31.1	C3L-00277	1.649e-05	9.634e-05	0	0	0	1.5e-05	0	0	rs143292161	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV64379749;OCCURENCE=1(stomach),1(skin)	TXNDC15	268	0	464	65	0.122873345935728	TRUE	TRUE
ENSG00000112659.14	.	BCM	GRCh38.p13	chr6	43187751	43187751	+	C	C	T	Silent	SNP	ENST00000252050.9	exon7	c.C1620T	p.S540S	exonic	ENSG00000112659.14	.	synonymous SNV	ENSG00000112659.14:ENST00000252050.9:exon7:c.C1620T:p.S540S	6p21.1	C3L-00277	3.3e-05	0	0	0	0	4.499e-05	0	6.064e-05	rs369198783	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CUL9	162	0	248	97	0.281159420289855	TRUE	NA
ENSG00000188676.13	.	BCM	GRCh38.p13	chr8	40005367	40005367	+	C	C	T	Silent	SNP	ENST00000502986.2	exon9	c.C747T	p.I249I	exonic	ENSG00000188676.13	.	synonymous SNV	ENSG00000188676.13:ENST00000502986.2:exon9:c.C747T:p.I249I	8p11.21	C3L-00277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IDO2	54	0	74	32	0.30188679245283	TRUE	TRUE
ENSG00000137103.20	.	BCM	GRCh38.p13	chr9	35853669	35853669	+	C	C	T	Silent	SNP	ENST00000377991.9	exon14	c.C1248T	p.L416L	exonic	ENSG00000137103.20	.	synonymous SNV	ENSG00000137103.20:ENST00000377991.9:exon14:c.C1248T:p.L416L	9p13.3	C3L-00277	.	.	.	.	.	.	.	.	rs1030771341	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM8B	183	0	231	69	0.23	TRUE	NA
ENSG00000150093.19	.	BCM	GRCh38.p13	chr10	32928140	32928140	+	T	T	C	Silent	SNP	ENST00000302278.8	exon5	c.A501G	p.T167T	exonic	ENSG00000150093.19	.	synonymous SNV	ENSG00000150093.19:ENST00000302278.8:exon5:c.A501G:p.T167T	10p11.22	C3L-00277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ITGB1	108	0	149	32	0.176795580110497	TRUE	TRUE
ENSG00000015133.19	.	BCM	GRCh38.p13	chr14	91417676	91417676	+	G	G	C	Silent	SNP	ENST00000389857.11	exon1	c.C15G	p.V5V	exonic	ENSG00000015133.19	.	synonymous SNV	ENSG00000015133.19:ENST00000389857.11:exon1:c.C15G:p.V5V	14q32.12	C3L-00277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCDC88C	158	0	264	120	0.3125	TRUE	NA
ENSG00000186297.12	.	BCM	GRCh38.p13	chr15	26937252	26937252	+	G	G	A	Silent	SNP	ENST00000335625.10	exon8	c.G648A	p.A216A	exonic	ENSG00000186297.12	.	synonymous SNV	ENSG00000186297.12:ENST00000335625.10:exon8:c.G648A:p.A216A	15q12	C3L-00277	8.291e-06	0	0	0	0	1.501e-05	0	0	rs778210544	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59476246;OCCURENCE=2(large_intestine),2(central_nervous_system),1(stomach)	GABRA5	222	0	323	100	0.236406619385343	TRUE	TRUE
ENSG00000006788.14	.	BCM	GRCh38.p13	chr17	10303202	10303202	+	C	C	T	Silent	SNP	ENST00000252172.9	exon39	c.G5661A	p.E1887E	exonic	ENSG00000006788.14	.	synonymous SNV	ENSG00000006788.14:ENST00000252172.9:exon39:c.G5661A:p.E1887E	17p13.1	C3L-00277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99354622;OCCURENCE=1(skin)	MYH13	124	0	205	63	0.235074626865672	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11769124	11769124	+	G	G	A	Silent	SNP	ENST00000262442.9	exon38	c.G7347A	p.A2449A	exonic	ENSG00000007174.18	.	synonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon38:c.G7347A:p.A2449A	17p12	C3L-00277	.	.	.	.	.	.	.	.	rs1048445167	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH9	232	0	377	82	0.178649237472767	TRUE	NA
ENSG00000089558.9	.	BCM	GRCh38.p13	chr17	42165620	42165620	+	G	G	A	Silent	SNP	ENST00000264661.4	exon11	c.C1914T	p.F638F	exonic	ENSG00000089558.9	.	synonymous SNV	ENSG00000089558.9:ENST00000264661.4:exon11:c.C1914T:p.F638F	17q21.2	C3L-00277	2.473e-05	9.626e-05	0	0	0	2.998e-05	0	0	rs371090330	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52917353;OCCURENCE=1(urinary_tract)	KCNH4	484	0	582	134	0.187150837988827	TRUE	TRUE
ENSG00000175221.15	.	BCM	GRCh38.p13	chr19	881614	881614	+	C	C	T	Silent	SNP	ENST00000325464.6	exon7	c.G1086A	p.S362S	exonic	ENSG00000175221.15	.	synonymous SNV	ENSG00000175221.15:ENST00000325464.6:exon7:c.G1086A:p.S362S	19p13.3	C3L-00277	1.671e-05	0	0	0	0	1.53e-05	0	6.061e-05	rs757826255	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54125914;OCCURENCE=1(liver)	MED16	141	0	248	80	0.24390243902439	TRUE	TRUE
ENSG00000241973.11	.	BCM	GRCh38.p13	chr22	20764888	20764888	+	G	G	A	Silent	SNP	ENST00000255882.11	exon22	c.C2637T	p.S879S	exonic	ENSG00000241973.11	.	synonymous SNV	ENSG00000241973.11:ENST00000255882.11:exon22:c.C2637T:p.S879S	22q11.21	C3L-00277	2.483e-05	0	0	0.0001	0	1.504e-05	0	6.157e-05	rs757543742	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PI4KA	79	0	136	16	0.105263157894737	TRUE	NA
ENSG00000143387.13	.	BCM	GRCh38.p13	chr1	150807342	150807342	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000143387.13	.	.	.	1q21.3	C3L-00277	.	.	.	.	.	.	.	.	.	1.13	D	.	.	.	.	N	.	T	N	.	T	T	.	0.087	0.230	0.746	.	.	T	T	T	T	T	0.668	8.160	0.963	N	N	-0.289	1.642	-0.389	1.392	1.000	0.554	0.588	0.492	0.466	.	4.240	3.330	0.230	0.119	0.599	0.000	0.004	0.358	65	.	.	.	.	CTSK	199	0	562	43	0.0710743801652893	TRUE	TRUE
ENSG00000177994.16	.	BCM	GRCh38.p13	chr2	54381899	54381899	+	G	G	A	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000177994.16;ENSG00000115306.16	dist=20318;dist=74428	.	.	2p16.2	C3L-00277	.	.	.	.	.	.	.	.	.	1.12	D	.	.	.	.	N	.	.	N	0.138	T	T	T	0.018	0.172	0.030	.	.	.	T	T	T	T	0.647	7.962	0.320	N	N	-0.543	1.094	-0.749	0.829	1.000	0.497	0.590	0.547	0.542	.	1.600	1.600	-0.285	0.791	0.596	0.000	0.003	0.003	564	.	.	.	.	C2orf73	175	0	274	62	0.18452380952381	TRUE	TRUE
ENSG00000053108.17	.	BCM	GRCh38.p13	chr5	133583339	133583339	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000053108.17	.	.	.	5q31.1	C3L-00277	.	.	.	.	.	.	.	.	.	2.13	D	D	.	.	.	N	.	T	N	.	T	T	.	0.061	0.321	0.082	.	.	.	T	T	T	T	0.261	3.834	0.930	N	N	-0.178	1.940	-0.310	1.544	0.009	0.455	0.590	0.607	0.564	.	.	.	.	.	.	.	.	.	415	.	.	.	.	FSTL4	82	0	108	23	0.175572519083969	TRUE	NA
ENSG00000255108.1	.	BCM	GRCh38.p13	chr11	829181	829181	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000255108.1	.	.	.	11p15.5	C3L-00277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AP006621.1	54	0	115	23	0.166666666666667	TRUE	NA
ENSG00000117713.20	.	BCM	GRCh38.p13	chr1	26763101	26763101	+	-	NA	A	Nonsense_Mutation	SNP	ENST00000324856.13	exon8	c.2549dupA	p.Y850*	exonic	ENSG00000117713.20	.	stopgain	ENSG00000117713.20:ENST00000324856.13:exon8:c.2549dupA:p.Y850*	1p36.11	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARID1A	NA	NA	NA	NA	NA	NA	NA
ENSG00000265972.6	.	BCM	GRCh38.p13	chr1	145994663	145994663	+	T	T	C	Missense_Mutation	SNP	ENST00000582401.6	exon5	c.A712G	p.R238G	exonic	ENSG00000265972.6	.	nonsynonymous SNV	ENSG00000265972.6:ENST00000582401.6:exon5:c.A712G:p.R238G	1q21.1	C3L-01328	.	.	.	.	.	.	.	.	.	5.7	D	D	.	.	.	.	.	T	D	0.888	.	.	.	.	.	.	.	.	T	.	.	.	D	4.110	27.800	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	1.934	1.137	0.661	0.995	1.000	0.996	958	Arrestin_C-terminal-like_domain	.	.	.	TXNIP	733	0	1117	100	0.0821692686935086	TRUE	TRUE
ENSG00000122224.18	.	BCM	GRCh38.p13	chr1	160796227	160796227	+	G	G	A	Missense_Mutation	SNP	ENST00000263285.11	exon1	c.G40A	p.G14R	exonic	ENSG00000122224.18	.	nonsynonymous SNV	ENSG00000122224.18:ENST00000263285.11:exon1:c.G40A:p.G14R	1q23.3	C3L-01328	1.648e-05	0	0	0	0	2.998e-05	0	0	rs369975202	0.18	T	T	B	B	.	N	.	T	N	0.143	T	T	T	0.010	.	0.346	0.072	T	T	T	T	T	T	1.018	11.850	0.527	N	N	-1.151	0.263	-1.179	0.301	1.000	0.500	0.522	0.624	0.564	.	2.860	0.959	0.322	0.062	0.575	0.000	0.001	0.027	789	.	.	.	.	LY9	220	0	403	28	0.0649651972157773	TRUE	NA
ENSG00000116183.11	.	BCM	GRCh38.p13	chr1	176739725	176739725	+	T	T	C	Missense_Mutation	SNP	ENST00000367662.5	exon13	c.T3898C	p.Y1300H	exonic	ENSG00000116183.11	.	nonsynonymous SNV	ENSG00000116183.11:ENST00000367662.5:exon13:c.T3898C:p.Y1300H	1q25.2	C3L-01328	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.117	T	T	T	0.057	0.544	0.234	0.223	T	T	T	T	T	T	0.723	8.664	0.128	N	N	-1.284	0.174	-1.221	0.266	0.000	0.487	0.574	0.574	0.564	.	5.670	1.060	1.385	-0.632	-0.135	0.124	0.001	0.033	730	.	.	.	.	PAPPA2	306	0	411	69	0.14375	TRUE	TRUE
ENSG00000143341.12	.	BCM	GRCh38.p13	chr1	186189628	186189628	+	G	G	A	Missense_Mutation	SNP	ENST00000271588.9	exon107	c.G16658A	p.R5553Q	exonic	ENSG00000143341.12	.	nonsynonymous SNV	ENSG00000143341.12:ENST00000271588.9:exon107:c.G16658A:p.R5553Q	1q31.1	C3L-01328	1.673e-05	9.747e-05	0	0.0001	0	0	0	0	rs148530862	16.20	D	D	D	D	D	D	M	T	D	0.520	D	D	T	0.565	.	0.893	0.447	T	T	D	D	D	D	4.389	31	0.999	D	D	0.904	11.155	0.909	14.140	1.000	0.706	0.588	0.710	0.563	.	5.910	5.910	9.940	1.176	0.676	1.000	1.000	1.000	662	.	.	.	ID=COSV54897273;OCCURENCE=1(stomach)	HMCN1	137	0	140	50	0.263157894736842	TRUE	TRUE
ENSG00000170802.16	.	BCM	GRCh38.p13	chr2	48374931	48374931	+	C	C	T	Missense_Mutation	SNP	ENST00000340553.8	exon7	c.C784T	p.L262F	exonic	ENSG00000170802.16	.	nonsynonymous SNV	ENSG00000170802.16:ENST00000340553.8:exon7:c.C784T:p.L262F	2p16.3	C3L-01328	.	.	.	.	.	.	.	.	.	8.20	D	T	B	B	N	D	L	D	N	0.254	D	D	D	0.206	0.403	0.966	0.087	T	T	T	T	D	T	2.197	20.800	0.998	D	N	0.001	2.515	0.112	2.786	0.999	0.563	0.654	0.609	0.636	.	5.080	4.200	2.639	1.025	0.599	0.988	1.000	0.999	687	.	.	.	.	FOXN2	100	0	164	12	0.0681818181818182	TRUE	TRUE
ENSG00000214336.5	.	BCM	GRCh38.p13	chr2	88448458	88448458	+	G	G	A	Missense_Mutation	SNP	ENST00000428390.3	exon2	c.C1012T	p.R338C	exonic	ENSG00000214336.5	.	nonsynonymous SNV	ENSG00000214336.5:ENST00000428390.3:exon2:c.C1012T:p.R338C	2p11.2	C3L-01328	.	.	.	.	.	.	.	.	rs922394321	3.10	.	T	D	P	.	.	M	.	.	0.100	.	.	.	.	.	0.401	.	T	T	T	T	.	T	4.155	28.200	0.575	D	.	.	.	.	.	0.964	0.134	0.085	0.184	0.075	0.178	4.130	3.250	2.581	1.176	-0.135	1.000	0.971	0.004	818	.	.	.	.	FOXI3	639	0	786	216	0.215568862275449	TRUE	NA
ENSG00000175874.10	.	BCM	GRCh38.p13	chr2	101383577	101383577	+	G	G	-	Frame_Shift_Del	NA	ENST00000324768.6	exon2	c.567delC	p.M190Wfs*4	exonic	ENSG00000175874.10	.	frameshift deletion	ENSG00000175874.10:ENST00000324768.6:exon2:c.567delC:p.M190Wfs*4	2q11.2	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CREG2	399	0	569	63	0.0996835443037975	TRUE	TRUE
ENSG00000213672.8	.	BCM	GRCh38.p13	chr3	48679842	48679842	+	C	C	T	Missense_Mutation	SNP	ENST00000294129.7	exon7	c.G1309A	p.E437K	exonic	ENSG00000213672.8	.	nonsynonymous SNV	ENSG00000213672.8:ENST00000294129.7:exon7:c.G1309A:p.E437K	3p21.31	C3L-01328	8.251e-05	0	0.0002	0	0	0	0	0.0005	rs201067488	3.20	T	T	B	B	U	N	L	T	N	0.475	T	T	D	0.045	.	0.775	0.154	T	T	T	T	T	D	1.984	19.130	0.996	D	N	-0.025	2.424	-0.021	2.290	1.000	0.646	0.696	0.702	0.636	.	5.200	4.320	1.888	1.026	0.599	0.989	0.615	0.812	3	.	.	.	.	NCKIPSD	375	0	372	136	0.267716535433071	TRUE	NA
ENSG00000144909.8	.	BCM	GRCh38.p13	chr3	125532005	125532005	+	C	C	T	Nonsense_Mutation	SNP	ENST00000296220.6	exon12	c.G2034A	p.W678X	exonic	ENSG00000144909.8	.	stopgain	ENSG00000144909.8:ENST00000296220.6:exon12:c.G2034A:p.W678X	3q21.2	C3L-01328	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.367	.	.	.	.	.	.	.	.	.	D	D	.	.	8.536	43	0.995	D	N	0.869	10.280	0.724	8.228	1.000	0.732	0.744	0.744	0.714	.	4.710	4.710	7.314	0.947	0.599	1.000	0.999	0.995	895	.	.	.	.	OSBPL11	173	0	235	27	0.103053435114504	TRUE	TRUE
ENSG00000137601.17	.	BCM	GRCh38.p13	chr4	169585428	169585428	+	G	G	T	Missense_Mutation	SNP	ENST00000439128.6	exon9	c.C728A	p.P243H	exonic	ENSG00000137601.17	.	nonsynonymous SNV	ENSG00000137601.17:ENST00000439128.6:exon9:c.C728A:p.P243H	4q33	C3L-01328	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.926	T	T	D	0.720	0.754	0.678	0.373	T	T	D	D	D	D	4.085	27.600	0.997	D	D	0.987	13.525	0.951	16.141	1.000	0.651	0.654	0.659	0.684	.	5.680	5.680	9.860	1.176	0.618	1.000	1.000	0.996	951	Protein_kinase_domain	.	.	ID=COSV71457147;OCCURENCE=1(endometrium)	NEK1	263	0	356	79	0.181609195402299	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971121	21971121	+	G	G	A	Nonsense_Mutation	SNP	ENST00000304494.9	exon2	c.C238T	p.R80X	exonic	ENSG00000147889.17	.	stopgain	ENSG00000147889.17:ENST00000304494.9:exon2:c.C238T:p.R80X	9p21.3	C3L-01328	.	.	.	.	.	.	.	.	rs121913388	9.16	T	D	.	.	N	D	.	D	D	0.305	T	T	.	0.480	.	0.977	.	T	T	D	D	D	T	7.418	38	0.998	D	D	0.265	3.604	0.302	3.727	1.000	0.677	0.383	0.608	0.601	.	5.930	5.010	1.260	1.176	0.676	0.882	0.552	0.951	900	.	.	.	ID=COSV58682746;OCCURENCE=1(salivary_gland),2(breast),17(penis),1(liver),29(oesophagus),6(large_intestine),4(central_nervous_system),9(biliary_tract),11(vulva),5(ovary),2(bone),7(NS),3(stomach),19(haematopoietic_and_lymphoid_tissue),2(soft_tissue),2(kidney),6(urinary_tract),26(pancreas),49(skin),1(prostate),15(lung),7(thyroid),70(upper_aerodigestive_tract),2(thymus),1(small_intestine),3(endometrium)	CDKN2A	643	0	725	249	0.25564681724846	TRUE	TRUE
ENSG00000106799.13	.	BCM	GRCh38.p13	chr9	99144809	99144809	+	G	G	A	Missense_Mutation	SNP	ENST00000374994.9	exon6	c.G1051A	p.D351N	exonic	ENSG00000106799.13	.	nonsynonymous SNV	ENSG00000106799.13:ENST00000374994.9:exon6:c.G1051A:p.D351N	9q22.33	C3L-01328	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.978	D	D	D	0.852	0.969	0.976	1.636	D	T	D	D	D	D	4.436	31	0.999	D	D	1.201	23.785	1.102	27.323	1.000	0.732	0.725	0.725	0.728	.	5.730	5.730	9.988	1.176	0.676	1.000	1.000	0.998	477	Protein_kinase_domain	.	.	.	TGFBR1	450	0	407	106	0.206627680311891	TRUE	TRUE
ENSG00000111241.2	.	BCM	GRCh38.p13	chr12	4445495	4445495	+	C	C	T	Missense_Mutation	SNP	ENST00000228837.2	exon1	c.G76A	p.V26I	exonic	ENSG00000111241.2	.	nonsynonymous SNV	ENSG00000111241.2:ENST00000228837.2:exon1:c.G76A:p.V26I	12p13.32	C3L-01328	2.487e-05	9.697e-05	0	0	0	1.506e-05	0	6.121e-05	rs767850309	1.20	T	T	B	B	N	D	N	T	N	0.079	T	T	T	0.022	0.343	0.244	0.174	T	T	T	T	T	T	-0.260	0.380	0.925	N	N	-1.093	0.313	-0.956	0.546	0.709	0.616	0.590	0.575	0.542	.	5.000	-0.352	-0.478	-0.241	-0.831	0.002	0.997	0.899	850	.	.	.	ID=COSV57404471;OCCURENCE=1(large_intestine)	FGF6	244	0	296	272	0.47887323943662	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-01328	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	506	0	543	358	0.397336293007769	TRUE	TRUE
ENSG00000132970.14	.	BCM	GRCh38.p13	chr13	26682705	26682705	+	G	G	A	Missense_Mutation	SNP	ENST00000335327.6	exon9	c.G1082A	p.S361N	exonic	ENSG00000132970.14	.	nonsynonymous SNV	ENSG00000132970.14:ENST00000335327.6:exon9:c.G1082A:p.S361N	13q12.13	C3L-01328	.	.	.	.	.	.	.	.	.	6.20	D	T	P	P	N	D	M	T	N	0.553	T	T	D	0.116	0.189	0.220	0.909	T	T	T	T	D	T	2.933	23.300	0.995	D	N	0.424	4.493	0.427	4.552	1.000	0.732	0.574	0.744	0.714	.	5.690	4.830	3.536	1.175	0.676	1.000	0.999	0.985	928	.	.	.	.	WASF3	683	1	669	85	0.112732095490716	TRUE	TRUE
ENSG00000102531.16	.	BCM	GRCh38.p13	chr13	49131150	49131150	+	A	A	G	Missense_Mutation	SNP	ENST00000492622.6	exon5	c.A266G	p.N89S	exonic	ENSG00000102531.16	.	nonsynonymous SNV	ENSG00000102531.16:ENST00000492622.6:exon5:c.A266G:p.N89S	13q14.2	C3L-01328	4.12e-05	0	0	0	0	1.499e-05	0	0.0002	rs774395306	11.20	T	T	D	D	D	D	M	T	D	0.835	T	T	T	0.194	0.473	0.454	0.352	T	D	T	T	D	D	3.063	23.500	0.997	D	D	0.345	4.017	0.367	4.133	1.000	0.707	0.698	0.725	0.714	.	5.650	4.480	7.708	0.321	-0.050	1.000	1.000	0.997	466	.	.	.	ID=COSV65696263;OCCURENCE=1(urinary_tract)	FNDC3A	307	0	404	60	0.129310344827586	TRUE	TRUE
ENSG00000102539.5	.	BCM	GRCh38.p13	chr13	49222291	49222291	+	G	G	A	Missense_Mutation	SNP	ENST00000218721.1	exon2	c.G1153A	p.D385N	exonic	ENSG00000102539.5	.	nonsynonymous SNV	ENSG00000102539.5:ENST00000218721.1:exon2:c.G1153A:p.D385N	13q14.2	C3L-01328	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	U	N	N	T	N	0.168	T	T	T	0.112	0.238	0.402	.	T	T	T	T	T	T	1.204	13.670	0.602	N	N	-1.431	0.104	-1.424	0.140	1.000	0.516	0.610	0.616	0.530	.	4.720	-1.410	1.828	-0.533	-0.712	0.223	0.009	0.040	665	.	.	.	.	MLNR	502	0	583	65	0.100308641975309	TRUE	TRUE
ENSG00000102452.17	.	BCM	GRCh38.p13	chr13	101061978	101061978	+	C	C	T	Missense_Mutation	SNP	ENST00000251127.11	exon41	c.G4745A	p.R1582H	exonic	ENSG00000102452.17	.	nonsynonymous SNV	ENSG00000102452.17:ENST00000251127.11:exon41:c.G4745A:p.R1582H	13q32.3	C3L-01328	8.327e-06	0	0	0.0001	0	0	0	0	rs764045715	19.20	D	D	D	D	D	D	L	D	D	0.677	D	D	D	0.664	0.436	0.687	2.726	D	D	D	D	D	D	4.221	28.900	1.000	D	D	0.739	7.706	0.769	9.257	1.000	0.638	0.574	0.574	0.668	.	5.820	5.820	7.353	1.026	0.599	1.000	0.999	0.977	846	.	.	.	ID=COSV51954405;OCCURENCE=1(thyroid)	NALCN	160	1	194	28	0.126126126126126	TRUE	TRUE
ENSG00000128918.15	.	BCM	GRCh38.p13	chr15	57963932	57963932	+	G	G	A	Missense_Mutation	SNP	ENST00000249750.9	exon9	c.C1039T	p.R347C	exonic	ENSG00000128918.15	.	nonsynonymous SNV	ENSG00000128918.15:ENST00000249750.9:exon9:c.C1039T:p.R347C	15q21.3	C3L-01328	2.472e-05	0	0	0	0	2.999e-05	0	6.058e-05	rs778997757	13.20	D	T	B	B	D	D	L	T	D	0.780	T	T	D	0.545	0.423	0.936	1.358	D	D	D	D	D	D	5.111	33	0.999	D	D	0.235	3.462	0.371	4.160	0.948	0.706	0.590	0.574	0.613	.	5.600	4.640	4.495	1.172	0.671	1.000	1.000	0.995	871	Aldehyde_dehydrogenase_domain	.	.	ID=COSV51092676;OCCURENCE=2(stomach),1(skin)	ALDH1A2	322	0	376	98	0.206751054852321	TRUE	TRUE
ENSG00000103888.17	.	BCM	GRCh38.p13	chr15	80884313	80884313	+	G	G	A	Missense_Mutation	SNP	ENST00000394685.8	exon7	c.G756A	p.M252I	exonic	ENSG00000103888.17	.	nonsynonymous SNV	ENSG00000103888.17:ENST00000394685.8:exon7:c.G756A:p.M252I	15q25.1	C3L-01328	8.249e-06	0	0	0	0	0	0	6.062e-05	rs562341405	3.20	T	T	B	B	D	D	N	T	N	0.365	T	T	T	0.056	0.412	0.472	0.411	T	T	T	T	T	T	1.960	18.950	0.571	D	N	-0.452	1.272	-0.183	1.827	0.998	0.161	0.563	0.409	0.530	.	5.380	5.380	3.094	1.136	0.665	1.000	0.994	0.990	934	Cell_surface_hyaluronidase,_PANDER-like_domain;ILEI/PANDER_domain	.	.	.	CEMIP	702	0	832	87	0.0946681175190424	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674220	7674220	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.G743A	p.R248Q	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.G743A:p.R248Q	17p13.1	C3L-01328	5.768e-05	0	0	0.0002	0	7.493e-05	0	0	rs11540652	19.20	D	D	D	D	D	A	M	D	D	0.946	D	D	D	0.934	.	0.975	0.412	T	D	D	D	D	D	4.282	29.400	0.999	D	D	0.660	6.591	0.561	5.765	0.799	0.722	0.702	0.725	0.735	.	4.620	3.650	6.163	1.021	0.596	1.000	0.981	0.841	433	p53,_DNA-binding_domain	.	.	ID=COSV52661580;OCCURENCE=3(salivary_gland),148(breast),3(penis),1(peritoneum),13(liver),1(genital_tract),73(oesophagus),2(adrenal_gland),1(meninges),4(cervix),277(large_intestine),71(central_nervous_system),10(biliary_tract),3(pleura),11(vulva),57(ovary),8(bone),8(NS),70(stomach),116(haematopoietic_and_lymphoid_tissue),6(soft_tissue),8(kidney),57(urinary_tract),34(pancreas),1(pituitary),23(skin),46(prostate),53(lung),18(thyroid),74(upper_aerodigestive_tract),1(testis),1(eye),1(thymus),11(small_intestine),44(endometrium)	TP53	442	0	444	211	0.322137404580153	TRUE	TRUE
ENSG00000198445.4	.	BCM	GRCh38.p13	chr22	16591778	16591778	+	G	G	A	Missense_Mutation	SNP	ENST00000359963.4	exon1	c.C773T	p.T258M	exonic	ENSG00000198445.4	.	nonsynonymous SNV	ENSG00000198445.4:ENST00000359963.4:exon1:c.C773T:p.T258M	22q11.1	C3L-01328	0.0002	0	0	0	0	0.0001	0	0.0006	rs147789853	7.19	D	D	D	P	N	N	.	T	D	0.150	T	D	T	0.168	.	0.289	0.419	T	D	T	T	D	T	1.755	17.410	0.991	N	N	-0.605	0.979	-0.925	0.586	0.000	0.487	0.574	0.578	0.564	.	1.980	-0.751	0.473	-1.363	-0.474	0.001	0.001	0.045	994	.	.	.	ID=COSV63461617;OCCURENCE=1(ovary),1(NS),1(skin),2(prostate),1(endometrium)	CCT8L2	644	1	753	113	0.130484988452656	NA	TRUE
ENSG00000171603.18	.	BCM	GRCh38.p13	chr1	9751651	9751651	+	C	C	A	Silent	SNP	ENST00000377298.9	exon5	c.G471T	p.V157V	exonic	ENSG00000171603.18	.	synonymous SNV	ENSG00000171603.18:ENST00000377298.9:exon5:c.G471T:p.V157V	1p36.22	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CLSTN1	364	1	561	72	0.113744075829384	TRUE	TRUE
ENSG00000142920.17	.	BCM	GRCh38.p13	chr1	33118036	33118036	+	C	C	T	Silent	SNP	ENST00000294517.11	exon11	c.C1164T	p.G388G	exonic	ENSG00000142920.17	.	synonymous SNV	ENSG00000142920.17:ENST00000294517.11:exon11:c.C1164T:p.G388G	1p35.1	C3L-01328	8.042e-05	0.0002	8.696e-05	0.0002	0	6.224e-05	0	0	rs61737104	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53860705;OCCURENCE=1(oesophagus)	AZIN2	102	0	114	35	0.23489932885906	TRUE	TRUE
ENSG00000138678.11	.	BCM	GRCh38.p13	chr4	83588213	83588213	+	C	C	T	Silent	SNP	ENST00000264409.5	exon5	c.C558T	p.L186L	exonic	ENSG00000138678.11	.	synonymous SNV	ENSG00000138678.11:ENST00000264409.5:exon5:c.C558T:p.L186L	4q21.23	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GPAT3	257	0	346	78	0.183962264150943	TRUE	TRUE
ENSG00000147596.4	.	BCM	GRCh38.p13	chr8	70069561	70069561	+	C	C	T	Silent	SNP	ENST00000276594.3	exon2	c.G300A	p.P100P	exonic	ENSG00000147596.4	.	synonymous SNV	ENSG00000147596.4:ENST00000276594.3:exon2:c.G300A:p.P100P	8q13.3	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRDM14	118	0	140	36	0.204545454545455	TRUE	TRUE
ENSG00000174576.10	.	BCM	GRCh38.p13	chr11	66422483	66422483	+	C	C	T	Silent	SNP	ENST00000311034.7	exon3	c.C360T	p.Y120Y	exonic	ENSG00000174576.10	.	synonymous SNV	ENSG00000174576.10:ENST00000311034.7:exon3:c.C360T:p.Y120Y	11q13.2	C3L-01328	7.414e-05	0	0	0.0002	0	7.492e-05	0	0.0001	rs377576767	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60651020;OCCURENCE=4(large_intestine),1(central_nervous_system),2(stomach),1(lung),1(endometrium)	NPAS4	468	1	629	67	0.0962643678160919	TRUE	TRUE
ENSG00000139351.15	.	BCM	GRCh38.p13	chr12	101737891	101737891	+	C	C	T	Silent	SNP	ENST00000392924.2	exon2	c.G45A	p.P15P	exonic	ENSG00000139351.15	.	synonymous SNV	ENSG00000139351.15:ENST00000392924.2:exon2:c.G45A:p.P15P	12q23.2	C3L-01328	1.647e-05	0	0	0	0	2.997e-05	0	0	rs566435135	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SYCP3	535	0	592	167	0.220026350461133	TRUE	NA
ENSG00000157895.11	.	BCM	GRCh38.p13	chr12	121011106	121011106	+	G	G	C	Silent	SNP	ENST00000288757.7	exon2	c.C186G	p.L62L	exonic	ENSG00000157895.11	.	synonymous SNV	ENSG00000157895.11:ENST00000288757.7:exon2:c.C186G:p.L62L	12q24.31	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C12orf43	435	0	528	116	0.180124223602484	TRUE	TRUE
ENSG00000108309.14	.	BCM	GRCh38.p13	chr17	44316472	44316472	+	G	G	A	Silent	SNP	ENST00000426726.8	exon9	c.G1041A	p.L347L	exonic	ENSG00000108309.14	.	synonymous SNV	ENSG00000108309.14:ENST00000426726.8:exon9:c.G1041A:p.L347L	17q21.31	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RUNDC3A	226	0	276	88	0.241758241758242	TRUE	TRUE
ENSG00000172519.9	.	BCM	GRCh38.p13	chr19	15794147	15794147	+	G	G	C	Silent	SNP	ENST00000642092.1	exon2	c.G99C	p.L33L	exonic	ENSG00000172519.9	.	synonymous SNV	ENSG00000172519.9:ENST00000642092.1:exon2:c.G99C:p.L33L	19p13.12	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100454611;OCCURENCE=1(lung)	OR10H5	268	0	379	38	0.0911270983213429	NA	TRUE
ENSG00000105643.10	.	BCM	GRCh38.p13	chr19	18008565	18008565	+	C	C	T	Silent	SNP	ENST00000222250.5	exon1	c.C255T	p.R85R	exonic	ENSG00000105643.10	.	synonymous SNV	ENSG00000105643.10:ENST00000222250.5:exon1:c.C255T:p.R85R	19p13.11	C3L-01328	8.027e-05	0	0	0.0005	0	0.0001	0	0	rs779259957	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARRDC2	174	0	335	94	0.219114219114219	TRUE	NA
ENSG00000197213.9	.	BCM	GRCh38.p13	chr19	56190073	56190073	+	G	G	A	Silent	SNP	ENST00000586855.6	exon5	c.C1242T	p.D414D	exonic	ENSG00000197213.9	.	synonymous SNV	ENSG00000197213.9:ENST00000586855.6:exon5:c.C1242T:p.D414D	19q13.43	C3L-01328	0.0003	0.0034	0.0002	0	0	2.997e-05	0	6.056e-05	rs199617146	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV62000266;OCCURENCE=1(large_intestine)	ZSCAN5B	371	0	348	112	0.243478260869565	TRUE	TRUE
ENSG00000163395.17	.	BCM	GRCh38.p13	chr1	201212833	201212833	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000163395.17	.	.	.	1q32.1	C3L-01328	.	.	.	.	.	.	.	.	.	2.15	D	D	.	.	.	N	.	T	N	0.101	T	T	T	0.033	.	0.214	.	T	.	T	T	T	T	1.478	15.590	0.688	N	N	-0.595	0.997	-0.680	0.929	0.000	0.500	0.590	0.624	0.542	.	3.210	2.260	0.220	1.167	0.608	0.000	0.236	0.095	917	.	.	.	.	IGFN1	184	0	288	64	0.181818181818182	TRUE	NA
ENSG00000151136.15	.	BCM	GRCh38.p13	chr12	107649294	107649294	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000151136.15	.	.	.	12q23.3	C3L-01328	.	.	.	.	.	.	.	.	.	1.15	D	.	B	B	.	N	.	T	N	0.070	T	T	T	0.015	0.303	0.068	.	.	.	T	T	T	T	-1.220	0.002	0.554	N	N	-1.565	0.063	-1.731	0.045	1.000	0.497	0.590	0.547	0.542	.	3.330	-6.650	-4.501	-3.508	-1.809	0.000	0.000	0.000	783	.	.	.	.	BTBD11	211	0	281	41	0.127329192546584	TRUE	NA
ENSG00000109511.12	.	BCM	GRCh38.p13	chr4	168184587	168184588	+	TC	TC	CA	Unknown	MNP	ENST00000359299.8	exon11	c.812_813delinsCA	p.I271T	exonic	ENSG00000109511.12	.	nonframeshift substitution	ENSG00000109511.12:ENST00000359299.8:exon11:c.812_813delinsCA:p.I271T	4q32.3	C3L-01328	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANXA10	287	0	375	5	0.0131578947368421	TRUE	NA
ENSG00000204478.9	.	BCM	GRCh38.p13	chr1	13418418	13418418	+	T	T	C	Missense_Mutation	SNP	ENST00000316412.9	exon3	c.T584C	p.I195T	exonic	ENSG00000204478.9	.	nonsynonymous SNV	ENSG00000204478.9:ENST00000316412.9:exon3:c.T584C:p.I195T	1p36.21	C3L-03639	.	.	.	.	.	.	.	.	.	3.17	D	D	.	.	N	N	.	T	D	0.287	T	T	T	0.072	0.692	0.030	.	T	T	T	T	T	T	0.159	2.672	0.828	N	N	-0.542	1.094	-0.781	0.784	0.000	0.487	0.574	0.574	0.564	.	1.680	1.680	-1.152	0.704	0.588	0.000	0.004	0.004	982	.	.	.	.	PRAMEF20	912	0	1039	224	0.17735550277118	TRUE	TRUE
ENSG00000169291.10	.	BCM	GRCh38.p13	chr1	154489204	154489204	+	C	C	T	Missense_Mutation	SNP	ENST00000304760.3	exon3	c.G871A	p.D291N	exonic	ENSG00000169291.10	.	nonsynonymous SNV	ENSG00000169291.10:ENST00000304760.3:exon3:c.G871A:p.D291N	1q21.3	C3L-03639	0.0003	9.737e-05	0	0	0	9.028e-05	0.0011	0.0015	rs12043246	13.20	D	D	D	D	D	D	M	T	D	0.923	T	T	D	0.325	.	0.782	1.121	T	D	T	T	T	D	3.466	24.600	0.999	D	D	0.752	7.915	0.677	7.338	1.000	0.722	0.547	0.602	0.735	.	5.610	5.610	5.796	1.026	0.599	1.000	0.796	0.073	425	.	.	.	ID=COSV59072909;OCCURENCE=1(stomach)	SHE	415	0	699	70	0.0910273081924577	TRUE	TRUE
ENSG00000160838.14	.	BCM	GRCh38.p13	chr1	156924691	156924691	+	C	C	T	Missense_Mutation	SNP	ENST00000337428.8	exon4	c.C488T	p.P163L	exonic	ENSG00000160838.14	.	nonsynonymous SNV	ENSG00000160838.14:ENST00000337428.8:exon4:c.C488T:p.P163L	1q23.1	C3L-03639	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	N	D	M	T	D	0.445	T	T	D	0.265	0.463	0.486	0.697	T	T	T	T	D	T	3.478	24.600	0.998	D	N	0.402	4.357	0.312	3.787	1.000	0.583	0.563	0.616	0.621	.	3.670	3.670	5.420	0.867	0.450	0.999	0.700	0.450	415	.	.	.	.	LRRC71	365	0	616	104	0.144444444444444	TRUE	TRUE
ENSG00000163554.15	.	BCM	GRCh38.p13	chr1	158666363	158666363	+	G	G	A	Nonsense_Mutation	SNP	ENST00000643759.2	exon16	c.C2173T	p.R725X	exonic	ENSG00000163554.15	.	stopgain	ENSG00000163554.15:ENST00000643759.2:exon16:c.C2173T:p.R725X	1q23.1	C3L-03639	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.840	.	.	.	.	.	.	.	.	.	D	D	.	.	7.420	38	0.995	D	N	0.240	3.487	-0.024	2.279	0.001	0.487	0.574	0.574	0.564	.	4.550	2.620	4.389	-0.755	-0.890	1.000	0.294	0.116	603	.	.	.	ID=COSV63749301;OCCURENCE=1(central_nervous_system),1(prostate),1(endometrium)	SPTA1	435	0	631	103	0.140326975476839	TRUE	TRUE
ENSG00000018625.15	.	BCM	GRCh38.p13	chr1	160129007	160129007	+	C	C	T	Missense_Mutation	SNP	ENST00000361216.8	exon10	c.C1244T	p.T415M	exonic	ENSG00000018625.15	.	nonsynonymous SNV	ENSG00000018625.15:ENST00000361216.8:exon10:c.C1244T:p.T415M	1q23.2	C3L-03639	2.459e-05	0	0.0003	0	0	0	0	0	rs121918618	18.20	D	D	D	D	D	A	M	T	D	0.865	D	D	D	0.785	0.781	0.945	1.764	T	D	D	D	D	D	3.486	24.700	0.998	D	D	0.374	4.188	0.246	3.415	1.000	0.719	0.590	0.723	0.542	.	4.130	4.130	7.905	1.013	0.599	1.000	0.954	0.819	851	.	.	.	ID=COSV63406206;OCCURENCE=1(kidney)	ATP1A2	507	1	850	113	0.117341640706127	TRUE	TRUE
ENSG00000158859.10	.	BCM	GRCh38.p13	chr1	161195635	161195635	+	C	C	T	Missense_Mutation	SNP	ENST00000367996.6	exon4	c.G1091A	p.G364D	exonic	ENSG00000158859.10	.	nonsynonymous SNV	ENSG00000158859.10:ENST00000367996.6:exon4:c.G1091A:p.G364D	1q23.3	C3L-03639	.	.	.	.	.	.	.	.	.	19.20	D	T	D	D	D	D	M	D	D	0.956	D	D	D	0.983	0.863	0.990	1.139	D	D	D	D	D	D	4.129	28.000	0.998	D	D	0.857	9.990	0.713	8.006	1.000	0.732	0.492	0.744	0.735	.	4.630	4.630	7.568	1.026	0.599	1.000	0.614	0.405	413	Peptidase_M12B,_ADAM/reprolysin	.	.	.	ADAMTS4	87	0	143	20	0.122699386503067	TRUE	TRUE
ENSG00000162761.14	.	BCM	GRCh38.p13	chr1	165249559	165249559	+	G	G	C	Nonsense_Mutation	SNP	ENST00000342310.7	exon4	c.C345G	p.Y115X	exonic	ENSG00000162761.14	.	stopgain	ENSG00000162761.14:ENST00000342310.7:exon4:c.C345G:p.Y115X	1q23.3	C3L-03639	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.921	.	.	.	.	.	.	.	.	.	D	D	.	.	8.297	42	0.998	D	N	0.826	9.302	0.685	7.479	1.000	0.616	0.574	0.618	0.564	.	4.610	4.610	4.960	1.176	0.618	1.000	0.998	0.999	916	Zinc_finger,_LIM-type	.	.	.	LMX1A	367	0	606	38	0.0590062111801242	TRUE	TRUE
ENSG00000198771.11	.	BCM	GRCh38.p13	chr1	167697690	167697690	+	G	G	C	Missense_Mutation	SNP	ENST00000367854.8	exon6	c.G1066C	p.V356L	exonic	ENSG00000198771.11	.	nonsynonymous SNV	ENSG00000198771.11:ENST00000367854.8:exon6:c.G1066C:p.V356L	1q24.2	C3L-03639	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.084	T	T	T	0.011	0.220	0.272	0.030	T	T	T	T	T	T	0.352	4.890	0.844	N	N	-1.062	0.341	-1.108	0.367	0.994	0.672	0.702	0.602	0.542	.	4.640	-1.260	-0.034	0.224	0.618	0.000	0.029	0.163	872	.	.	.	.	RCSD1	86	0	146	15	0.093167701863354	TRUE	TRUE
ENSG00000010165.20	.	BCM	GRCh38.p13	chr1	171796740	171796740	+	C	C	T	Missense_Mutation	SNP	ENST00000361735.4	exon8	c.C2084T	p.T695M	exonic	ENSG00000010165.20	.	nonsynonymous SNV	ENSG00000010165.20:ENST00000361735.4:exon8:c.C2084T:p.T695M	1q24.3	C3L-03639	3.31e-05	0	0	0.0001	0	4.515e-05	0	0	rs575314244	1.20	T	T	P	B	N	N	L	T	N	0.124	T	T	T	0.020	0.340	0.396	0.229	T	T	T	T	T	T	1.252	14.040	0.969	D	N	-0.229	1.796	-0.121	1.988	1.000	0.707	0.725	0.725	0.714	.	5.640	4.730	2.485	0.129	-0.171	0.965	0.832	0.212	686	.	.	.	ID=COSV62283000;OCCURENCE=1(breast),1(endometrium)	EEF1AKNMT	217	0	296	39	0.116417910447761	TRUE	TRUE
ENSG00000158715.6	.	BCM	GRCh38.p13	chr1	205659331	205659331	+	G	G	A	Missense_Mutation	SNP	ENST00000367145.4	exon5	c.C1565T	p.A522V	exonic	ENSG00000158715.6	.	nonsynonymous SNV	ENSG00000158715.6:ENST00000367145.4:exon5:c.C1565T:p.A522V	1q32.1	C3L-03639	.	.	.	.	.	.	.	.	.	8.20	T	T	P	B	D	D	M	T	N	0.554	T	T	T	0.418	0.351	0.398	0.533	T	T	D	D	D	T	3.517	24.800	0.999	D	D	0.530	5.279	0.652	6.946	1.000	0.713	0.546	0.636	0.684	.	5.880	5.880	9.941	1.176	0.618	1.000	0.991	0.995	686	.	.	.	.	SLC45A3	370	1	379	47	0.110328638497653	TRUE	TRUE
ENSG00000182795.13	.	BCM	GRCh38.p13	chr1	207027567	207027567	+	G	G	A	Missense_Mutation	SNP	ENST00000359470.6	exon2	c.C32T	p.T11I	exonic	ENSG00000182795.13	.	nonsynonymous SNV	ENSG00000182795.13:ENST00000359470.6:exon2:c.C32T:p.T11I	1q32.1	C3L-03639	.	.	.	.	.	.	.	.	.	1.15	T	T	.	.	N	D	.	T	N	0.114	T	T	T	0.058	0.162	0.030	0.077	.	.	T	T	T	T	2.402	22.100	0.993	N	N	-0.447	1.283	-0.219	1.741	1.000	0.497	0.563	0.496	0.542	.	5.630	3.740	2.220	0.245	0.676	1.000	0.898	0.990	784	.	.	.	.	C1orf116	342	0	505	60	0.106194690265487	TRUE	TRUE
ENSG00000143473.13	.	BCM	GRCh38.p13	chr1	210804146	210804146	+	A	A	C	Missense_Mutation	SNP	ENST00000271751.10	exon8	c.T1483G	p.F495V	exonic	ENSG00000143473.13	.	nonsynonymous SNV	ENSG00000143473.13:ENST00000271751.10:exon8:c.T1483G:p.F495V	1q32.2	C3L-03639	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	L	D	D	0.823	D	D	D	0.931	0.566	0.997	2.854	D	D	D	D	D	D	4.017	27.100	0.992	D	D	0.712	7.295	0.729	8.329	1.000	0.500	0.624	0.624	0.564	.	5.660	5.660	8.987	1.312	0.756	1.000	0.997	0.952	934	Ion_transport_domain	.	.	ID=COSV55068201;OCCURENCE=1(oesophagus)	KCNH1	257	1	349	41	0.105128205128205	TRUE	TRUE
ENSG00000144229.12	.	BCM	GRCh38.p13	chr2	137272601	137272601	+	T	T	G	Missense_Mutation	SNP	ENST00000409968.6	exon11	c.T2335G	p.C779G	exonic	ENSG00000144229.12	.	nonsynonymous SNV	ENSG00000144229.12:ENST00000409968.6:exon11:c.T2335G:p.C779G	2q22.1	C3L-03639	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	D	D	.	T	D	0.877	T	T	D	0.558	0.675	0.770	0.339	T	T	D	D	D	D	4.159	28.300	0.988	D	D	0.893	10.883	0.839	11.381	0.991	0.554	0.574	0.602	0.564	.	5.720	5.720	7.226	1.138	0.665	1.000	0.999	0.992	822	.	.	.	.	THSD7B	300	1	302	32	0.0958083832335329	TRUE	TRUE
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	141229236	141229236	+	T	T	A	Missense_Mutation	SNP	ENST00000389484.8	exon6	c.A797T	p.K266I	exonic	ENSG00000168702.18	.	nonsynonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon6:c.A797T:p.K266I	2q22.1	C3L-03639	.	.	.	.	.	.	.	.	.	11.20	D	D	P	P	U	D	M	D	N	0.529	D	D	D	0.560	0.602	0.419	0.344	T	T	D	T	D	T	2.900	23.200	0.990	D	N	0.204	3.320	0.219	3.276	0.005	0.487	0.574	0.574	0.564	.	5.200	3.990	1.531	1.138	0.609	1.000	1.000	0.998	639	.	.	.	.	LRP1B	267	0	185	84	0.312267657992565	TRUE	TRUE
ENSG00000153253.18	.	BCM	GRCh38.p13	chr2	165139592	165139592	+	G	G	A	Missense_Mutation	SNP	ENST00000360093.7	exon14	c.C2036T	p.T679M	exonic	ENSG00000153253.18	.	nonsynonymous SNV	ENSG00000153253.18:ENST00000360093.7:exon14:c.C2036T:p.T679M	2q24.3	C3L-03639	4.123e-05	9.614e-05	8.681e-05	0	0	2.999e-05	0.0011	0	rs139860168	16.20	D	T	D	P	D	D	M	D	D	0.572	D	D	D	0.541	.	0.745	1.010	T	D	T	D	D	D	2.482	22.400	0.995	D	D	0.622	6.151	0.670	7.228	1.000	0.487	0.547	0.574	0.564	.	5.650	5.650	5.774	1.176	0.676	1.000	0.923	0.679	853	Voltage-gated_Na+_ion_channel,_cytoplasmic_domain	.	.	ID=COSV51802949;OCCURENCE=1(breast),1(oesophagus),2(large_intestine)	SCN3A	404	0	420	40	0.0869565217391304	TRUE	TRUE
ENSG00000185038.14	.	BCM	GRCh38.p13	chr2	233805083	233805083	+	C	C	T	Missense_Mutation	SNP	ENST00000389758.3	exon19	c.C2024T	p.A675V	exonic	ENSG00000185038.14	.	nonsynonymous SNV	ENSG00000185038.14:ENST00000389758.3:exon19:c.C2024T:p.A675V	2q37.1	C3L-03639	.	.	.	.	.	.	.	.	rs1056895420	0.16	T	T	.	.	N	N	.	T	N	0.042	T	T	T	0.059	0.274	0.014	0.000	.	T	T	T	T	T	0.761	9.019	0.932	N	N	-0.977	0.429	-0.929	0.581	0.001	0.487	0.590	0.574	0.613	.	5.450	-1.690	0.466	-1.394	-2.031	0.880	0.000	0.001	813	.	.	.	.	MROH2A	294	0	379	39	0.0933014354066986	TRUE	NA
ENSG00000168038.11	.	BCM	GRCh38.p13	chr3	41800179	41800179	+	G	G	C	Missense_Mutation	SNP	ENST00000301831.9	exon20	c.C1963G	p.L655V	exonic	ENSG00000168038.11	.	nonsynonymous SNV	ENSG00000168038.11:ENST00000301831.9:exon20:c.C1963G:p.L655V	3p22.1	C3L-03639	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	U	D	M	T	N	0.683	T	T	D	0.388	0.413	0.659	0.210	T	T	D	D	D	D	3.938	26.600	0.997	D	D	0.474	4.839	0.402	4.374	0.972	0.615	0.588	0.659	0.655	.	5.320	4.440	6.200	1.176	0.676	1.000	0.926	0.782	690	.	.	.	.	ULK4	141	0	141	46	0.245989304812834	TRUE	TRUE
ENSG00000163814.8	.	BCM	GRCh38.p13	chr3	45089118	45089118	+	C	C	A	Missense_Mutation	SNP	ENST00000296129.6	exon8	c.G2017T	p.A673S	exonic	ENSG00000163814.8	.	nonsynonymous SNV	ENSG00000163814.8:ENST00000296129.6:exon8:c.G2017T:p.A673S	3p21.31	C3L-03639	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.341	T	T	T	0.057	0.446	0.316	0.414	T	T	T	T	D	T	1.442	15.360	0.928	N	N	-0.520	1.138	-0.530	1.154	1.000	0.563	0.590	0.609	0.586	.	5.700	4.820	2.439	1.026	0.599	0.011	0.002	0.010	567	.	.	.	.	CDCP1	263	0	352	38	0.0974358974358974	TRUE	TRUE
ENSG00000114270.17	.	BCM	GRCh38.p13	chr3	48579271	48579271	+	G	G	A	Missense_Mutation	SNP	ENST00000328333.12	exon61	c.C5314T	p.R1772W	exonic	ENSG00000114270.17	.	nonsynonymous SNV	ENSG00000114270.17:ENST00000328333.12:exon61:c.C5314T:p.R1772W	3p21.31	C3L-03639	.	.	.	.	.	.	.	.	rs1032335328	18.20	D	D	D	D	N	D	M	D	D	0.849	D	D	D	0.749	.	0.947	0.259	T	D	D	D	D	D	4.271	29.300	0.998	D	D	0.769	8.205	0.694	7.645	0.999	0.646	0.627	0.645	0.613	.	5.160	5.160	2.445	1.176	0.676	0.984	0.964	0.990	11	.	.	.	.	COL7A1	634	0	757	198	0.207329842931937	TRUE	NA
ENSG00000001617.12	.	BCM	GRCh38.p13	chr3	50175146	50175146	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000002829.8	exon6	c.508dupA	p.T170Nfs*23	exonic	ENSG00000001617.12	.	frameshift insertion	ENSG00000001617.12:ENST00000002829.8:exon6:c.508dupA:p.T170Nfs*23	3p21.31	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEMA3F	NA	NA	NA	NA	NA	NA	NA
ENSG00000163637.13	.	BCM	GRCh38.p13	chr3	64147338	64147338	+	C	C	A	Missense_Mutation	SNP	ENST00000638394.2	exon7	c.G1152T	p.Q384H	exonic	ENSG00000163637.13	.	nonsynonymous SNV	ENSG00000163637.13:ENST00000638394.2:exon7:c.G1152T:p.Q384H	3p14.1	C3L-03639	.	.	.	.	.	.	.	.	.	11.16	.	.	D	P	D	D	M	.	.	.	T	T	D	0.344	0.119	0.782	1.335	T	T	D	D	D	D	3.535	24.800	0.991	D	D	0.239	3.480	0.195	3.161	1.000	0.563	0.588	0.609	0.492	.	5.940	5.070	3.048	1.026	-0.202	1.000	0.997	0.070	784	.	.	.	.	PRICKLE2	253	0	344	101	0.226966292134831	TRUE	TRUE
ENSG00000118017.4	.	BCM	GRCh38.p13	chr3	138124394	138124394	+	C	C	T	Missense_Mutation	SNP	ENST00000236709.4	exon3	c.G893A	p.R298Q	exonic	ENSG00000118017.4	.	nonsynonymous SNV	ENSG00000118017.4:ENST00000236709.4:exon3:c.G893A:p.R298Q	3q22.3	C3L-03639	2.471e-05	0	0	0	0	1.498e-05	0	0.0001	rs771025283	5.20	T	D	D	B	N	N	M	T	N	0.087	T	T	D	0.372	0.545	0.319	0.156	T	T	T	T	D	T	0.672	8.195	0.997	N	N	-0.565	1.052	-0.788	0.775	1.000	0.549	0.574	0.578	0.616	.	5.530	-5.190	-1.078	-0.217	0.599	0.000	0.000	0.053	556	Alpha_1,4-glycosyltransferase_domain	.	.	ID=COSV52629476;OCCURENCE=1(lung)	A4GNT	443	0	486	102	0.173469387755102	TRUE	TRUE
ENSG00000075651.16	.	BCM	GRCh38.p13	chr3	171699756	171699756	+	T	T	C	Missense_Mutation	SNP	ENST00000351298.9	exon12	c.A1216G	p.K406E	exonic	ENSG00000075651.16	.	nonsynonymous SNV	ENSG00000075651.16:ENST00000351298.9:exon12:c.A1216G:p.K406E	3q26.31	C3L-03639	.	.	.	.	.	.	.	.	.	8.20	T	T	B	B	D	D	M	T	D	0.818	T	T	T	0.224	0.480	0.442	0.180	T	T	T	T	D	D	3.403	24.400	0.998	D	D	0.399	4.340	0.470	4.896	1.000	0.732	0.547	0.618	0.728	.	4.880	4.880	7.808	1.138	0.665	1.000	1.000	1.000	962	.	.	.	.	PLD1	142	0	138	28	0.168674698795181	TRUE	TRUE
ENSG00000182903.16	.	BCM	GRCh38.p13	chr4	441898	441898	+	T	T	A	Nonsense_Mutation	SNP	ENST00000338977.5	exon2	c.A2533T	p.R845X	exonic	ENSG00000182903.16	.	stopgain	ENSG00000182903.16:ENST00000338977.5:exon2:c.A2533T:p.R845X	4p16.3	C3L-03639	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	D	.	.	.	0.029	.	.	.	.	.	.	.	.	.	D	D	.	.	5.967	35	0.991	N	N	-0.199	1.879	-0.602	1.043	0.025	0.732	0.744	0.702	0.592	.	0.499	0.499	-0.826	0.496	0.476	0.000	0.102	0.076	912	Zinc_finger_C2H2-type	.	.	.	ZNF721	394	0	467	121	0.20578231292517	NA	TRUE
ENSG00000157404.16	.	BCM	GRCh38.p13	chr4	54698428	54698428	+	G	G	T	Missense_Mutation	SNP	ENST00000288135.6	exon3	c.G482T	p.R161M	exonic	ENSG00000157404.16	.	nonsynonymous SNV	ENSG00000157404.16:ENST00000288135.6:exon3:c.G482T:p.R161M	4q12	C3L-03639	.	.	.	.	.	.	.	.	.	1.20	D	T	B	B	N	N	L	T	N	0.238	T	T	T	0.150	0.463	0.642	0.501	T	T	T	T	T	T	1.139	13.130	0.862	N	N	-1.023	0.380	-1.025	0.458	0.990	0.732	0.574	0.744	0.632	.	5.750	-0.886	-0.755	0.113	0.665	0.000	0.259	0.628	894	.	.	.	ID=COSV55423622;OCCURENCE=1(large_intestine)	KIT	441	0	411	118	0.223062381852552	TRUE	TRUE
ENSG00000163739.5	.	BCM	GRCh38.p13	chr4	73869749	73869749	+	A	A	G	Missense_Mutation	SNP	ENST00000395761.4	exon2	c.A181G	p.N61D	exonic	ENSG00000163739.5	.	nonsynonymous SNV	ENSG00000163739.5:ENST00000395761.4:exon2:c.A181G:p.N61D	4q13.3	C3L-03639	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.240	T	T	T	0.009	0.322	0.386	0.156	T	T	T	T	T	T	1.211	13.720	0.901	N	N	-1.159	0.257	-1.212	0.273	1.000	0.628	0.563	0.504	0.658	.	4.850	-0.812	0.120	-0.533	-0.074	0.089	0.000	0.010	429	CXC_chemokine,_conserved_site;Chemokine_interleukin-8-like_domain;CXC_Chemokine_domain	.	.	.	CXCL1	336	0	469	118	0.201022146507666	NA	TRUE
ENSG00000186212.4	.	BCM	GRCh38.p13	chr4	76896021	76896021	+	A	A	C	Missense_Mutation	SNP	ENST00000334306.4	exon1	c.T1829G	p.I610S	exonic	ENSG00000186212.4	.	nonsynonymous SNV	ENSG00000186212.4:ENST00000334306.4:exon1:c.T1829G:p.I610S	4q21.1	C3L-03639	.	.	.	.	.	.	.	.	.	1.20	T	D	B	B	U	N	L	T	N	0.138	T	T	T	0.026	0.399	0.163	.	T	T	T	T	T	T	1.172	13.410	0.641	N	N	-0.985	0.420	-0.954	0.548	1.000	0.598	0.541	0.615	0.639	.	5.230	1.040	0.150	0.268	0.756	0.000	0.376	0.442	545	.	.	.	.	SOWAHB	136	0	177	16	0.0829015544041451	TRUE	TRUE
ENSG00000164066.13	.	BCM	GRCh38.p13	chr4	127706694	127706694	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000335251.11	exon12	c.1997dupA	p.T668Nfs*3	exonic	ENSG00000164066.13	.	frameshift insertion	ENSG00000164066.13:ENST00000335251.11:exon12:c.1997dupA:p.T668Nfs*3	4q28.1	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INTU	NA	NA	NA	NA	NA	NA	NA
ENSG00000164306.11	.	BCM	GRCh38.p13	chr4	184661857	184661857	+	C	C	T	Missense_Mutation	SNP	ENST00000314970.11	exon5	c.C362T	p.A121V	exonic	ENSG00000164306.11	.	nonsynonymous SNV	ENSG00000164306.11:ENST00000314970.11:exon5:c.C362T:p.A121V	4q35.1	C3L-03639	.	.	.	.	.	.	.	.	.	7.20	T	T	D	D	N	D	M	T	N	0.247	T	T	T	0.134	0.407	0.494	0.215	T	T	T	T	D	D	2.084	19.890	0.999	D	N	0.282	3.687	0.287	3.644	1.000	0.651	0.709	0.659	0.684	.	5.800	4.080	2.887	0.948	0.530	0.993	0.997	0.996	894	.	.	.	.	PRIMPOL	183	0	177	26	0.12807881773399	TRUE	TRUE
ENSG00000083857.14	.	BCM	GRCh38.p13	chr4	186707942	186707942	+	G	G	C	Missense_Mutation	SNP	ENST00000441802.7	exon2	c.C1886G	p.S629W	exonic	ENSG00000083857.14	.	nonsynonymous SNV	ENSG00000083857.14:ENST00000441802.7:exon2:c.C1886G:p.S629W	4q35.2	C3L-03639	.	.	.	.	.	.	.	.	.	13.20	D	D	D	P	D	D	M	T	D	0.612	T	T	D	0.331	0.492	0.492	0.483	T	D	T	T	D	D	3.333	24.200	0.991	D	D	0.667	6.682	0.603	6.261	1.000	0.672	0.574	0.702	0.668	.	5.400	5.400	10.003	1.176	0.676	1.000	0.002	0.001	951	Cadherin-like	.	.	.	FAT1	325	0	318	65	0.169712793733681	TRUE	TRUE
ENSG00000040731.10	.	BCM	GRCh38.p13	chr5	24487886	24487886	+	T	T	G	Missense_Mutation	SNP	ENST00000264463.8	exon12	c.A2144C	p.N715T	exonic	ENSG00000040731.10	.	nonsynonymous SNV	ENSG00000040731.10:ENST00000264463.8:exon12:c.A2144C:p.N715T	5p14.2	C3L-03639	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	D	D	M	T	N	0.215	T	T	T	0.288	0.475	0.821	0.483	T	T	T	T	D	T	2.243	21.200	0.989	D	N	0.003	2.520	-0.010	2.324	1.000	0.487	0.574	0.574	0.564	.	5.680	4.500	1.616	1.134	0.661	0.999	0.544	0.999	858	Cadherin,_cytoplasmic_domain	.	.	.	CDH10	358	1	397	42	0.0956719817767654	TRUE	TRUE
ENSG00000152582.14	.	BCM	GRCh38.p13	chr5	35641463	35641463	+	G	G	A	Missense_Mutation	SNP	ENST00000356031.8	exon3	c.G194A	p.R65H	exonic	ENSG00000152582.14	.	nonsynonymous SNV	ENSG00000152582.14:ENST00000356031.8:exon3:c.G194A:p.R65H	5p13.2	C3L-03639	4.128e-05	0	8.714e-05	0	0	3.002e-05	0	0.0001	rs772509398	14.20	D	D	D	D	D	D	M	T	D	0.691	T	T	D	0.355	0.706	0.356	0.249	T	T	T	D	D	D	3.903	26.400	0.999	D	D	0.835	9.509	0.825	10.890	0.999	0.554	0.574	0.618	0.564	.	5.930	5.930	5.520	1.155	0.676	1.000	1.000	0.998	609	CH-like_domain_in_sperm_protein;Calponin_homology_domain	.	.	ID=COSV56796785;OCCURENCE=2(liver),1(large_intestine)	SPEF2	205	0	283	1054	0.788332086761406	TRUE	TRUE
ENSG00000053108.17	.	BCM	GRCh38.p13	chr5	133220828	133220828	+	C	C	T	Missense_Mutation	SNP	ENST00000265342.12	exon12	c.G1378A	p.D460N	exonic	ENSG00000053108.17	.	nonsynonymous SNV	ENSG00000053108.17:ENST00000265342.12:exon12:c.G1378A:p.D460N	5q31.1	C3L-03639	0.0002	0	0.0015	0	0	2.997e-05	0	6.056e-05	rs201737601	4.20	T	D	B	B	N	D	L	T	N	0.400	T	T	T	0.083	.	0.341	0.226	T	T	T	T	T	D	0.678	8.250	0.911	D	N	-0.563	1.055	-0.585	1.070	0.999	0.615	0.588	0.616	0.447	.	5.480	0.679	1.617	0.129	-0.242	0.822	0.003	0.342	887	.	.	.	.	FSTL4	352	0	418	95	0.185185185185185	TRUE	NA
ENSG00000070614.15	.	BCM	GRCh38.p13	chr5	150521486	150521486	+	C	C	T	Missense_Mutation	SNP	ENST00000261797.7	exon2	c.C232T	p.P78S	exonic	ENSG00000070614.15	.	nonsynonymous SNV	ENSG00000070614.15:ENST00000261797.7:exon2:c.C232T:p.P78S	5q33.1	C3L-03639	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	N	T	N	0.075	T	T	T	0.063	0.119	0.155	0.669	T	T	T	T	T	T	1.486	15.640	0.281	D	N	-0.552	1.077	-0.383	1.404	1.000	0.707	0.654	0.702	0.714	.	5.110	3.990	1.798	1.026	0.599	0.271	0.911	0.684	872	Heparan_sulphate-N-deacetylase	.	.	.	NDST1	562	0	802	55	0.0641773628938156	TRUE	TRUE
ENSG00000145990.11	.	BCM	GRCh38.p13	chr6	13365539	13365539	+	G	G	A	Missense_Mutation	SNP	ENST00000379287.4	exon2	c.C377T	p.P126L	exonic	ENSG00000145990.11	.	nonsynonymous SNV	ENSG00000145990.11:ENST00000379287.4:exon2:c.C377T:p.P126L	6p24.1	C3L-03639	8.377e-06	0	0	0	0	1.532e-05	0	0	rs757177243	19.20	D	D	D	D	D	D	H	D	D	0.967	D	D	D	0.880	0.790	0.985	2.194	D	T	D	D	D	D	4.265	29.300	0.999	D	D	0.936	12.018	0.888	13.255	1.000	0.672	0.702	0.616	0.492	.	5.150	5.150	9.968	1.176	0.671	1.000	0.997	0.997	866	.	.	.	ID=COSV64954512;OCCURENCE=1(skin)	GFOD1	444	0	644	108	0.143617021276596	TRUE	NA
ENSG00000112655.16	.	BCM	GRCh38.p13	chr6	43139520	43139520	+	G	G	A	Missense_Mutation	SNP	ENST00000230419.9	exon10	c.G1613A	p.R538Q	exonic	ENSG00000112655.16	.	nonsynonymous SNV	ENSG00000112655.16:ENST00000230419.9:exon10:c.G1613A:p.R538Q	6p21.1	C3L-03639	.	.	.	.	.	.	.	.	.	10.20	D	D	D	P	D	D	M	T	N	0.274	T	T	D	0.191	0.723	0.511	1.764	T	T	T	T	D	D	3.878	26.200	0.999	D	N	0.567	5.601	0.552	5.670	0.999	0.706	0.634	0.644	0.613	.	5.590	4.720	5.201	1.176	0.618	1.000	0.845	0.707	249	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	PTK7	136	0	181	111	0.38013698630137	TRUE	TRUE
ENSG00000180113.16	.	BCM	GRCh38.p13	chr6	46688271	46688271	+	G	G	A	Missense_Mutation	SNP	ENST00000316081.11	exon1	c.G143A	p.R48Q	exonic	ENSG00000180113.16	.	nonsynonymous SNV	ENSG00000180113.16:ENST00000316081.11:exon1:c.G143A:p.R48Q	6p12.3	C3L-03639	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.105	T	T	D	0.030	0.356	0.334	0.034	T	T	T	T	T	T	0.891	10.340	0.990	N	N	-0.603	0.981	-0.547	1.128	0.000	0.487	0.574	0.578	0.542	.	5.200	0.668	0.106	0.201	-0.760	0.000	0.995	0.821	502	Tudor_domain	.	.	.	TDRD6	193	0	377	56	0.12933025404157	TRUE	NA
ENSG00000164418.20	.	BCM	GRCh38.p13	chr6	102068476	102068476	+	G	G	A	Missense_Mutation	SNP	ENST00000421544.6	exon19	c.G2692A	p.D898N	exonic	ENSG00000164418.20	.	nonsynonymous SNV	ENSG00000164418.20:ENST00000421544.6:exon19:c.G2692A:p.D898N	6q16.3	C3L-03639	8.37e-06	9.728e-05	0	0	0	0	0	0	rs751533944	7.20	D	T	P	B	D	D	L	T	N	0.699	T	T	T	0.211	0.229	0.602	0.504	D	T	T	T	T	D	3.433	24.500	0.999	D	D	0.455	4.705	0.570	5.869	1.000	0.554	0.574	0.618	0.564	.	5.790	5.790	9.561	1.176	0.676	1.000	1.000	1.000	905	.	.	.	ID=COSV59729088;OCCURENCE=1(large_intestine)	GRIK2	151	0	124	85	0.406698564593301	TRUE	TRUE
ENSG00000164877.19	.	BCM	GRCh38.p13	chr7	1444926	1444926	+	G	G	A	Missense_Mutation	SNP	ENST00000297508.8	exon6	c.C1144T	p.P382S	exonic	ENSG00000164877.19	.	nonsynonymous SNV	ENSG00000164877.19:ENST00000297508.8:exon6:c.C1144T:p.P382S	7p22.3	C3L-03639	0	0	0	0	0	0	0	0	rs774800327	2.20	T	T	B	B	N	N	L	T	D	0.090	T	T	D	0.019	0.371	0.324	0.015	T	T	T	T	T	T	-0.059	1.009	0.656	N	N	-1.269	0.182	-1.334	0.188	0.249	0.646	0.588	0.576	0.700	.	3.880	-1.690	-0.005	-0.262	-0.115	0.009	0.000	0.001	938	.	.	.	.	MICALL2	77	0	164	56	0.254545454545455	TRUE	NA
ENSG00000105866.15	.	BCM	GRCh38.p13	chr7	21428767	21428767	+	A	A	G	Missense_Mutation	SNP	ENST00000222584.8	exon2	c.A98G	p.K33R	exonic	ENSG00000105866.15	.	nonsynonymous SNV	ENSG00000105866.15:ENST00000222584.8:exon2:c.A98G:p.K33R	7p15.3	C3L-03639	.	.	.	.	.	.	.	.	.	6.20	D	T	P	B	D	D	N	T	N	0.306	T	T	T	0.146	0.181	0.252	0.247	T	T	T	T	D	T	2.826	23.100	0.948	D	D	0.129	3.002	0.225	3.308	1.000	0.243	0.299	0.391	0.373	.	4.650	4.650	5.843	1.312	0.756	1.000	1.000	1.000	866	.	.	.	.	SP4	207	0	448	43	0.0875763747454175	TRUE	TRUE
ENSG00000105778.19	.	BCM	GRCh38.p13	chr7	32552236	32552236	+	A	A	G	Missense_Mutation	SNP	ENST00000318709.9	exon6	c.A470G	p.Y157C	exonic	ENSG00000105778.19	.	nonsynonymous SNV	ENSG00000105778.19:ENST00000318709.9:exon6:c.A470G:p.Y157C	7p14.3	C3L-03639	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.931	T	T	D	0.825	0.750	0.817	0.800	D	T	D	D	D	D	4.366	31	0.998	D	D	0.895	10.918	0.859	12.091	1.000	0.707	0.725	0.651	0.714	.	5.650	5.650	8.628	1.311	0.756	1.000	1.000	0.998	705	Tripartite_DENN_domain;AVL9/DENND6_domain	.	.	.	AVL9	85	0	114	14	0.109375	TRUE	TRUE
ENSG00000091128.13	.	BCM	GRCh38.p13	chr7	108076970	108076970	+	C	C	T	Missense_Mutation	SNP	ENST00000388781.8	exon17	c.G2098A	p.A700T	exonic	ENSG00000091128.13	.	nonsynonymous SNV	ENSG00000091128.13:ENST00000388781.8:exon17:c.G2098A:p.A700T	7q31.1	C3L-03639	5.774e-05	0	0	0	0	0	0	0.0004	rs754196717	0.20	T	T	B	B	N	N	L	T	N	0.075	T	T	T	0.010	0.402	0.014	0.062	T	T	T	T	T	T	-0.021	1.209	0.738	N	N	-1.527	0.073	-1.530	0.097	0.988	0.487	0.574	0.547	0.634	.	5.300	0.207	-0.410	-0.824	-1.051	0.001	0.030	0.029	729	Laminin_IV_type_B	.	.	ID=COSV52726584;OCCURENCE=1(breast)	LAMB4	174	0	270	48	0.150943396226415	TRUE	TRUE
ENSG00000183117.19	.	BCM	GRCh38.p13	chr8	3307810	3307810	+	C	C	A	Missense_Mutation	SNP	ENST00000635120.2	exon25	c.G3835T	p.G1279C	exonic	ENSG00000183117.19	.	nonsynonymous SNV	ENSG00000183117.19:ENST00000635120.2:exon25:c.G3835T:p.G1279C	8p23.2	C3L-03639	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	N	D	.	T	D	0.945	D	D	D	0.560	0.838	0.602	.	T	T	D	D	D	D	3.900	26.300	0.997	D	D	0.463	4.763	0.357	4.068	0.445	0.554	0.574	0.618	0.564	.	4.610	4.610	5.979	1.000	0.599	1.000	0.137	0.849	922	CUB_domain	.	.	.	CSMD1	148	0	185	10	0.0512820512820513	TRUE	TRUE
ENSG00000077782.21	.	BCM	GRCh38.p13	chr8	38424658	38424658	+	C	C	T	Missense_Mutation	SNP	ENST00000447712.7	exon7	c.G787A	p.A263T	exonic	ENSG00000077782.21	.	nonsynonymous SNV	ENSG00000077782.21:ENST00000447712.7:exon7:c.G787A:p.A263T	8p11.23	C3L-03639	2.489e-05	0	0	0	0	0	0	0.0002	rs747978107	15.20	D	D	D	D	D	D	N	T	D	0.718	T	T	D	0.436	0.567	0.817	2.306	D	D	T	D	D	D	3.538	24.800	0.999	D	D	0.648	6.452	0.735	8.459	1.000	0.722	0.588	0.702	0.735	.	6.080	6.080	7.905	1.025	0.599	1.000	0.902	0.754	845	Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	FGFR1	95	0	111	41	0.269736842105263	TRUE	NA
ENSG00000176406.23	.	BCM	GRCh38.p13	chr8	103885963	103885963	+	G	G	A	Missense_Mutation	SNP	ENST00000666250.1	exon4	c.G1364A	p.R455Q	exonic	ENSG00000176406.23	.	nonsynonymous SNV	ENSG00000176406.23:ENST00000666250.1:exon4:c.G1364A:p.R455Q	8q22.3	C3L-03639	.	.	.	.	.	.	.	.	.	8.18	D	T	D	D	.	D	.	T	N	0.443	T	T	T	0.181	.	0.642	.	T	T	T	T	D	D	3.930	26.500	0.999	D	D	0.387	4.266	0.377	4.202	0.999	0.693	0.574	0.659	0.564	.	5.650	4.780	5.511	1.176	0.676	1.000	0.997	0.995	631	.	.	.	ID=COSV51653092;OCCURENCE=1(haematopoietic_and_lymphoid_tissue),2(stomach)	RIMS2	360	0	533	68	0.113144758735441	TRUE	TRUE
ENSG00000177283.7	.	BCM	GRCh38.p13	chr10	35640073	35640073	+	A	A	T	Missense_Mutation	SNP	ENST00000374694.2	exon1	c.T1357A	p.S453T	exonic	ENSG00000177283.7	.	nonsynonymous SNV	ENSG00000177283.7:ENST00000374694.2:exon1:c.T1357A:p.S453T	10p11.21	C3L-03639	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	U	D	N	T	N	0.678	T	T	D	0.449	0.558	0.376	.	D	T	T	T	D	D	2.072	19.800	0.633	D	D	-0.531	1.116	-0.378	1.412	1.000	0.789	0.588	0.768	0.604	.	3.810	3.810	6.930	1.025	0.514	1.000	0.997	0.528	733	GPCR,_family_2-like;Frizzled/Smoothened,_transmembrane_domain	.	.	.	FZD8	314	0	684	38	0.0526315789473684	TRUE	TRUE
ENSG00000107651.13	.	BCM	GRCh38.p13	chr10	119933007	119933007	+	-	NA	A	Frame_Shift_Ins	NA	ENST00000369075.8	exon17	c.2762dupA	p.V923Gfs*3	exonic	ENSG00000107651.13	.	frameshift insertion	ENSG00000107651.13:ENST00000369075.8:exon17:c.2762dupA:p.V923Gfs*3	10q26.12	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEC23IP	NA	NA	NA	NA	NA	NA	NA
ENSG00000181752.3	.	BCM	GRCh38.p13	chr11	56159519	56159519	+	A	A	C	Missense_Mutation	SNP	ENST00000313447.1	exon1	c.T799G	p.F267V	exonic	ENSG00000181752.3	.	nonsynonymous SNV	ENSG00000181752.3:ENST00000313447.1:exon1:c.T799G:p.F267V	11q12.1	C3L-03639	.	.	.	.	.	.	.	.	.	3.20	D	D	B	B	D	N	N	T	N	0.050	T	T	T	0.153	0.436	0.294	0.005	T	T	T	T	T	T	1.344	14.700	0.975	N	N	-0.797	0.659	-0.729	0.858	0.000	0.487	0.574	0.574	0.564	.	3.980	3.980	0.261	0.983	0.647	0.000	0.001	0.002	161	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV100537127;OCCURENCE=1(stomach)	OR8K5	226	0	251	54	0.177049180327869	TRUE	TRUE
ENSG00000159063.13	.	BCM	GRCh38.p13	chr11	78124139	78124139	+	A	A	T	Missense_Mutation	SNP	ENST00000299626.10	exon3	c.T250A	p.Y84N	exonic	ENSG00000159063.13	.	nonsynonymous SNV	ENSG00000159063.13:ENST00000299626.10:exon3:c.T250A:p.Y84N	11q14.1	C3L-03639	.	.	.	.	.	.	.	.	.	13.20	D	D	P	P	N	D	M	D	D	0.728	T	D	D	0.515	0.457	0.943	0.473	T	D	D	T	D	D	3.570	24.900	0.974	D	N	0.295	3.754	0.315	3.807	0.366	0.732	0.710	0.725	0.728	.	6.010	3.570	3.020	1.312	0.756	1.000	1.000	0.995	638	.	.	.	.	ALG8	196	0	878	47	0.0508108108108108	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-03639	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	298	0	213	174	0.449612403100775	TRUE	TRUE
ENSG00000198393.8	.	BCM	GRCh38.p13	chr12	133011428	133011428	+	A	A	G	Missense_Mutation	SNP	ENST00000328654.10	exon4	c.A1549G	p.K517E	exonic	ENSG00000198393.8	.	nonsynonymous SNV	ENSG00000198393.8:ENST00000328654.10:exon4:c.A1549G:p.K517E	12q24.33	C3L-03639	.	.	.	.	.	.	.	.	.	5.20	D	D	B	B	N	N	L	T	D	0.215	T	T	T	0.092	0.493	0.067	.	T	T	T	T	D	T	2.929	23.300	0.999	D	N	-0.065	2.287	-0.031	2.257	0.011	0.707	0.725	0.659	0.636	.	4.030	2.870	4.089	1.031	0.658	1.000	0.998	0.995	934	Zinc_finger_C2H2-type	.	.	.	ZNF26	90	0	107	21	0.1640625	TRUE	TRUE
ENSG00000196199.14	.	BCM	GRCh38.p13	chr13	19659276	19659276	+	A	A	G	Missense_Mutation	SNP	ENST00000361479.10	exon7	c.A1778G	p.N593S	exonic	ENSG00000196199.14	.	nonsynonymous SNV	ENSG00000196199.14:ENST00000361479.10:exon7:c.A1778G:p.N593S	13q12.11	C3L-03639	.	.	.	.	.	.	.	.	.	11.20	D	D	D	D	D	D	L	T	N	0.469	T	T	D	0.362	0.341	0.703	0.780	T	T	T	T	D	D	3.844	26.000	0.999	D	D	0.647	6.438	0.655	6.992	1.000	0.707	0.725	0.786	0.714	.	5.180	5.180	8.480	1.312	0.756	1.000	0.997	0.974	946	Ankyrin_repeat-containing_domain	.	.	.	MPHOSPH8	77	0	135	19	0.123376623376623	TRUE	TRUE
ENSG00000136111.14	.	BCM	GRCh38.p13	chr13	75362211	75362211	+	G	G	A	Missense_Mutation	SNP	ENST00000377636.8	exon2	c.C895T	p.R299W	exonic	ENSG00000136111.14	.	nonsynonymous SNV	ENSG00000136111.14:ENST00000377636.8:exon2:c.C895T:p.R299W	13q22.2	C3L-03639	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	L	T	N	0.614	T	T	T	0.214	0.417	0.649	0.913	T	T	T	T	D	D	3.132	23.700	0.994	D	D	-0.218	1.826	-0.403	1.367	1.000	0.706	0.634	0.710	0.714	.	5.180	-2.140	1.076	0.161	0.676	1.000	0.722	0.147	938	PTB/PI_domain	.	.	.	TBC1D4	596	0	845	165	0.163366336633663	TRUE	TRUE
ENSG00000102452.17	.	BCM	GRCh38.p13	chr13	101067961	101067961	+	C	C	T	Missense_Mutation	SNP	ENST00000251127.11	exon39	c.G4403A	p.R1468H	exonic	ENSG00000102452.17	.	nonsynonymous SNV	ENSG00000102452.17:ENST00000251127.11:exon39:c.G4403A:p.R1468H	13q32.3	C3L-03639	.	.	.	.	.	.	.	.	.	18.20	D	D	D	P	D	D	N	D	D	0.766	D	D	D	0.798	0.511	0.724	2.231	D	D	D	D	D	D	3.520	24.800	0.999	D	D	0.629	6.234	0.701	7.764	1.000	0.638	0.574	0.618	0.668	.	5.900	5.900	7.568	1.026	0.599	1.000	0.998	0.987	840	.	.	.	ID=COSV51916921;OCCURENCE=2(haematopoietic_and_lymphoid_tissue),1(endometrium)	NALCN	201	0	275	44	0.137931034482759	TRUE	TRUE
ENSG00000129484.13	.	BCM	GRCh38.p13	chr14	20346866	20346866	+	C	C	T	Missense_Mutation	SNP	ENST00000250416.9	exon4	c.C316T	p.H106Y	exonic	ENSG00000129484.13	.	nonsynonymous SNV	ENSG00000129484.13:ENST00000250416.9:exon4:c.C316T:p.H106Y	14q11.2	C3L-03639	8.288e-06	0	0	0.0001	0	0	0	0	rs761099507	10.20	D	T	D	D	D	D	L	T	D	0.825	T	T	T	0.247	0.586	0.537	0.209	T	T	T	T	D	D	3.007	23.400	0.997	D	D	0.697	7.076	0.730	8.344	1.000	0.707	0.725	0.725	0.714	.	5.860	5.860	6.614	1.008	0.581	1.000	0.997	0.981	911	.	.	.	.	PARP2	183	0	165	37	0.183168316831683	TRUE	NA
ENSG00000187790.11	.	BCM	GRCh38.p13	chr14	45175500	45175500	+	G	G	T	Missense_Mutation	SNP	ENST00000267430.10	exon14	c.G2746T	p.V916F	exonic	ENSG00000187790.11	.	nonsynonymous SNV	ENSG00000187790.11:ENST00000267430.10:exon14:c.G2746T:p.V916F	14q21.2	C3L-03639	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	M	T	N	0.216	T	T	T	0.045	0.302	0.210	0.127	T	T	T	T	T	T	-0.174	0.582	0.977	N	N	-1.030	0.373	-1.056	0.422	0.423	0.615	0.588	0.602	0.655	.	4.350	2.480	0.300	-0.146	-0.919	0.000	0.042	0.055	819	.	.	.	.	FANCM	82	0	113	8	0.0661157024793388	TRUE	TRUE
ENSG00000100731.16	.	BCM	GRCh38.p13	chr14	70978357	70978357	+	G	G	A	Missense_Mutation	SNP	ENST00000304743.7	exon6	c.G2020A	p.A674T	exonic	ENSG00000100731.16	.	nonsynonymous SNV	ENSG00000100731.16:ENST00000304743.7:exon6:c.G2020A:p.A674T	14q24.2	C3L-03639	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.033	T	T	T	0.083	0.199	0.043	0.100	T	T	T	T	T	T	1.664	16.790	0.977	D	N	-0.430	1.318	-0.321	1.521	0.996	0.707	0.654	0.725	0.714	.	5.870	0.155	0.850	0.222	0.674	0.999	0.565	0.876	773	.	.	.	.	PCNX1	121	0	167	20	0.106951871657754	TRUE	TRUE
ENSG00000140937.14	.	BCM	GRCh38.p13	chr16	65004788	65004788	+	G	G	A	Missense_Mutation	SNP	ENST00000268603.9	exon3	c.C82T	p.R28W	exonic	ENSG00000140937.14	.	nonsynonymous SNV	ENSG00000140937.14:ENST00000268603.9:exon3:c.C82T:p.R28W	16q21	C3L-03639	1.655e-05	0	0	0.0003	0	0	0	0	rs779648442	7.20	D	D	D	P	N	D	L	T	D	0.429	T	T	D	0.145	0.439	0.530	0.995	T	T	T	T	T	D	2.744	22.900	0.959	N	N	-0.120	2.112	-0.157	1.894	0.897	0.638	0.574	0.653	0.655	.	5.740	2.590	0.370	1.176	0.618	0.000	0.101	0.606	413	.	.	.	.	CDH11	260	0	293	80	0.214477211796247	TRUE	NA
ENSG00000184811.4	.	BCM	GRCh38.p13	chr17	1280056	1280056	+	G	G	A	Missense_Mutation	SNP	ENST00000333813.4	exon1	c.G55A	p.A19T	exonic	ENSG00000184811.4	.	nonsynonymous SNV	ENSG00000184811.4:ENST00000333813.4:exon1:c.G55A:p.A19T	17p13.3	C3L-03639	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	N	.	T	N	0.021	T	T	D	0.067	0.163	0.072	0.049	T	T	T	T	T	T	0.296	4.244	0.878	N	N	-1.533	0.072	-1.473	0.118	0.000	0.554	0.588	0.578	0.542	.	5.220	1.680	1.219	-0.583	-2.444	0.018	0.016	0.006	710	.	.	.	ID=COSV61562600;OCCURENCE=1(large_intestine),1(stomach)	TRARG1	85	0	145	26	0.152046783625731	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674897	7674899	+	AAG	AAG	-	In_Frame_Del	DEL	ENST00000269305.8	exon6	c.632_634del	p.T211_F212delinsI	exonic	ENSG00000141510.17	.	nonframeshift deletion	ENSG00000141510.17:ENST00000269305.8:exon6:c.632_634del:p.T211_F212delinsI	17p13.1	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	482	0	374	265	0.41471048513302	TRUE	TRUE
ENSG00000277161.2	.	BCM	GRCh38.p13	chr17	36537813	36537813	+	T	T	G	Missense_Mutation	SNP	ENST00000614443.2	exon2	c.T712G	p.F238V	exonic	ENSG00000277161.2	.	nonsynonymous SNV	ENSG00000277161.2:ENST00000614443.2:exon2:c.T712G:p.F238V	17q12	C3L-03639	.	.	.	.	.	.	.	.	.	15.17	.	D	D	D	D	D	H	.	.	0.947	D	D	D	0.955	0.921	0.656	.	T	T	D	D	D	D	3.985	26.900	0.991	D	D	0.903	11.139	0.842	11.494	1.000	0.707	0.702	0.609	0.714	.	5.790	5.790	7.432	1.138	0.665	1.000	1.000	1.000	622	.	.	.	.	PIGW	151	0	148	65	0.305164319248826	TRUE	TRUE
ENSG00000173801.17	.	BCM	GRCh38.p13	chr17	41757684	41757684	+	C	C	T	Missense_Mutation	SNP	ENST00000393931.8	exon11	c.G1874A	p.G625E	exonic	ENSG00000173801.17	.	nonsynonymous SNV	ENSG00000173801.17:ENST00000393931.8:exon11:c.G1874A:p.G625E	17q21.2	C3L-03639	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.882	T	T	D	0.653	0.727	0.872	1.590	D	D	D	D	D	D	3.827	26.000	0.998	D	D	0.658	6.574	0.609	6.338	1.000	0.707	0.725	0.725	0.714	.	4.980	4.980	7.694	0.947	0.599	1.000	0.955	0.719	577	.	.	.	.	JUP	130	0	201	43	0.176229508196721	TRUE	TRUE
ENSG00000120068.7	.	BCM	GRCh38.p13	chr17	48614428	48614428	+	G	G	A	Missense_Mutation	SNP	ENST00000239144.5	exon1	c.C277T	p.R93C	exonic	ENSG00000120068.7	.	nonsynonymous SNV	ENSG00000120068.7:ENST00000239144.5:exon1:c.C277T:p.R93C	17q21.32	C3L-03639	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	U	D	M	T	D	0.780	T	T	D	0.343	0.467	0.816	2.433	D	T	D	T	D	D	4.446	32	0.998	D	N	0.355	4.075	0.195	3.160	1.000	0.598	0.596	0.000	0.604	.	2.970	0.652	2.433	1.082	0.511	1.000	1.000	0.994	643	.	.	.	.	HOXB8	242	0	253	191	0.43018018018018	TRUE	TRUE
ENSG00000185269.12	.	BCM	GRCh38.p13	chr17	81957895	81957895	+	G	G	T	Missense_Mutation	SNP	ENST00000409678.8	exon6	c.C606A	p.F202L	exonic	ENSG00000185269.12	.	nonsynonymous SNV	ENSG00000185269.12:ENST00000409678.8:exon6:c.C606A:p.F202L	17q25.3	C3L-03639	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	H	.	D	0.987	T	T	D	0.800	0.851	0.157	1.487	D	D	D	D	D	D	3.607	25.100	0.998	D	D	0.492	4.971	0.336	3.937	1.000	0.583	0.590	0.615	0.563	.	4.510	2.450	3.085	1.083	0.618	1.000	0.967	0.371	.	.	.	.	.	NOTUM	234	1	331	103	0.237327188940092	TRUE	TRUE
ENSG00000215421.9	.	BCM	GRCh38.p13	chr18	74633568	74633568	+	G	G	A	Missense_Mutation	SNP	ENST00000299687.9	exon1	c.G2549A	p.R850Q	exonic	ENSG00000215421.9	.	nonsynonymous SNV	ENSG00000215421.9:ENST00000299687.9:exon1:c.G2549A:p.R850Q	18q22.3	C3L-03639	.	.	.	.	.	.	.	.	.	8.20	D	T	D	D	N	N	L	T	N	0.472	T	T	D	0.279	0.471	0.397	0.500	T	T	T	T	D	D	4.144	28.100	1.000	D	D	0.613	6.063	0.621	6.491	1.000	0.615	0.654	0.659	0.636	.	5.630	5.630	7.106	1.176	0.676	1.000	0.994	0.996	730	Zinc_finger_C2H2-type	.	.	ID=COSV55241328;OCCURENCE=1(large_intestine)	ZNF407	196	0	192	43	0.182978723404255	TRUE	TRUE
ENSG00000005206.17	.	BCM	GRCh38.p13	chr19	2334692	2334692	+	G	G	A	Missense_Mutation	SNP	ENST00000613503.5	exon2	c.G157A	p.A53T	exonic	ENSG00000005206.17;ENSG00000273734.1	.	nonsynonymous SNV	ENSG00000005206.17:ENST00000613503.5:exon2:c.G157A:p.A53T	19p13.3	C3L-03639	.	.	.	.	.	.	.	.	.	8.14	.	T	D	D	D	.	N	.	.	0.860	T	T	.	0.255	0.440	0.040	.	T	T	D	D	D	D	3.226	23.900	0.996	D	.	0.454	4.696	0.429	4.570	1.000	0.295	0.304	0.341	0.293	0.878	4.280	4.280	9.503	1.083	0.676	1.000	0.907	0.396	964	.	.	.	.	SPPL2B	187	0	292	88	0.231578947368421	TRUE	TRUE
ENSG00000172009.15	.	BCM	GRCh38.p13	chr19	2790583	2790583	+	C	C	G	Missense_Mutation	SNP	ENST00000307741.11	exon2	c.C179G	p.S60C	exonic	ENSG00000172009.15	.	nonsynonymous SNV	ENSG00000172009.15:ENST00000307741.11:exon2:c.C179G:p.S60C	19p13.3	C3L-03639	.	.	.	.	.	.	.	.	.	8.20	D	D	B	B	D	D	M	T	N	0.492	T	T	T	0.194	0.595	0.388	0.744	T	T	T	T	D	T	2.411	22.100	0.961	D	D	-0.185	1.920	-0.074	2.122	1.000	0.707	0.672	0.725	0.714	.	5.030	5.030	3.425	1.026	0.599	0.997	0.032	0.007	994	.	.	.	.	THOP1	52	0	88	6	0.0638297872340425	TRUE	NA
ENSG00000276043.5	.	BCM	GRCh38.p13	chr19	4950741	4950741	+	G	G	A	Missense_Mutation	SNP	ENST00000650932.1	exon12	c.G1648A	p.A550T	exonic	ENSG00000276043.5	.	nonsynonymous SNV	ENSG00000276043.5:ENST00000650932.1:exon12:c.G1648A:p.A550T	19p13.3	C3L-03639	6.82e-05	0.0001	0	0	0	4.601e-05	0.0012	0.0002	rs371287720	0.14	.	T	B	B	N	.	N	.	.	0.133	T	T	.	0.026	.	0.081	.	T	T	T	T	T	T	0.798	9.373	0.984	N	.	-0.952	0.457	-0.957	0.544	0.001	0.322	0.304	0.331	0.323	0.111	5.140	1.170	1.479	1.176	0.676	0.029	0.053	0.012	952	SRA-YDG	.	.	.	UHRF1	164	0	209	42	0.167330677290837	TRUE	NA
ENSG00000185236.12	.	BCM	GRCh38.p13	chr19	8390435	8390435	+	G	G	T	Nonsense_Mutation	SNP	ENST00000328024.11	exon1	c.G19T	p.E7X	exonic	ENSG00000185236.12	.	stopgain	ENSG00000185236.12:ENST00000328024.11:exon1:c.G19T:p.E7X	19p13.2	C3L-03639	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.853	.	.	.	.	.	.	.	.	.	D	D	.	.	8.566	44	0.997	D	N	0.996	13.789	0.847	11.671	1.000	0.442	0.522	0.522	0.562	.	5.720	4.670	6.712	1.176	0.618	1.000	0.999	0.983	808	.	.	.	ID=COSV100033165;OCCURENCE=1(kidney)	RAB11B	88	0	153	48	0.238805970149254	TRUE	TRUE
ENSG00000128011.4	.	BCM	GRCh38.p13	chr19	39307719	39307719	+	C	C	A	Missense_Mutation	SNP	ENST00000248668.4	exon2	c.G2230T	p.G744W	exonic	ENSG00000128011.4	.	nonsynonymous SNV	ENSG00000128011.4:ENST00000248668.4:exon2:c.G2230T:p.G744W	19q13.2	C3L-03639	.	.	.	.	.	.	.	.	.	5.20	T	T	P	B	N	N	N	T	N	0.411	T	T	D	0.090	0.380	0.134	.	D	T	T	T	D	T	2.910	23.200	0.994	D	D	0.134	3.024	0.202	3.195	1.000	0.652	0.588	0.641	0.621	.	4.360	3.240	1.548	1.022	0.596	0.932	1.000	0.997	560	.	.	.	.	LRFN1	75	0	322	17	0.0501474926253687	TRUE	NA
ENSG00000105323.17	.	BCM	GRCh38.p13	chr19	41304163	41304163	+	A	A	-	Frame_Shift_Del	DEL	ENST00000392006.8	exon13	c.2164delA	p.N722Tfs*193	exonic	ENSG00000105323.17	.	frameshift deletion	ENSG00000105323.17:ENST00000392006.8:exon13:c.2164delA:p.N722Tfs*193	19q13.2	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HNRNPUL1	266	2	504	87	0.147208121827411	TRUE	TRUE
ENSG00000213024.12	.	BCM	GRCh38.p13	chr19	49908289	49908289	+	C	C	T	Missense_Mutation	SNP	ENST00000352066.8	exon3	c.G1519A	p.E507K	exonic	ENSG00000213024.12	.	nonsynonymous SNV	ENSG00000213024.12:ENST00000352066.8:exon3:c.G1519A:p.E507K	19q13.33	C3L-03639	.	.	.	.	.	.	.	.	.	8.20	D	T	P	B	U	D	L	T	D	0.469	T	T	D	0.129	0.336	0.641	0.354	T	T	T	T	D	D	2.880	23.200	0.999	D	D	0.289	3.722	0.354	4.046	1.000	0.731	0.750	0.699	0.714	.	5.260	4.230	7.182	1.026	0.599	1.000	0.956	0.975	645	.	.	.	ID=COSV61311921;OCCURENCE=1(lung)	NUP62	224	0	334	78	0.189320388349515	TRUE	TRUE
ENSG00000142528.16	.	BCM	GRCh38.p13	chr19	50046946	50046946	+	G	G	C	Missense_Mutation	SNP	ENST00000270617.8	exon5	c.G2503C	p.V835L	exonic	ENSG00000142528.16	.	nonsynonymous SNV	ENSG00000142528.16:ENST00000270617.8:exon5:c.G2503C:p.V835L	19q13.33	C3L-03639	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.079	T	T	T	0.024	0.596	0.215	0.437	T	T	T	T	T	T	0.354	4.911	0.934	N	N	-1.058	0.345	-1.113	0.362	1.000	0.719	0.723	0.780	0.636	.	4.380	-1.200	-0.231	0.275	-0.142	0.000	0.992	0.636	740	Zinc_finger_C2H2-type	.	.	ID=COSV54522812;OCCURENCE=2(lung)	ZNF473	270	0	370	22	0.0561224489795918	TRUE	TRUE
ENSG00000198300.14	.	BCM	GRCh38.p13	chr19	56815930	56815930	+	A	A	C	Missense_Mutation	SNP	ENST00000326441.15	exon10	c.T2512G	p.L838V	exonic	ENSG00000198300.14	.	nonsynonymous SNV	ENSG00000198300.14:ENST00000326441.15:exon10:c.T2512G:p.L838V	19q13.43	C3L-03639	.	.	.	.	.	.	.	.	.	2.19	T	D	P	B	N	.	M	T	N	0.146	T	T	T	0.025	0.400	0.346	0.101	T	T	T	T	T	T	-0.390	0.202	0.569	N	N	-0.893	0.530	-1.129	0.347	0.048	0.487	0.574	0.574	0.564	.	3.990	-4.480	-0.859	1.312	0.691	0.000	0.159	0.013	976	.	.	.	.	PEG3	46	0	43	16	0.271186440677966	TRUE	TRUE
ENSG00000196476.12	.	BCM	GRCh38.p13	chr20	279284	279284	+	C	C	T	Missense_Mutation	SNP	ENST00000360321.7	exon5	c.G353A	p.R118H	exonic	ENSG00000196476.12	.	nonsynonymous SNV	ENSG00000196476.12:ENST00000360321.7:exon5:c.G353A:p.R118H	20p13	C3L-03639	8.389e-06	0	0	0	0	0	0	6.08e-05	rs754475212	0.19	T	T	B	B	N	N	N	T	N	0.271	T	T	T	0.083	0.246	0.199	0.053	.	T	T	T	T	T	0.775	9.148	0.779	N	N	-1.699	0.037	-1.533	0.096	1.000	0.789	0.710	0.768	0.692	.	4.920	3.820	0.621	-0.139	-0.661	0.245	0.010	0.002	862	.	.	.	.	C20orf96	374	1	592	97	0.140783744557329	TRUE	NA
ENSG00000101333.16	.	BCM	GRCh38.p13	chr20	9457453	9457453	+	C	C	G	Missense_Mutation	SNP	ENST00000378493.5	exon30	c.C3000G	p.I1000M	exonic	ENSG00000101333.16	.	nonsynonymous SNV	ENSG00000101333.16:ENST00000378493.5:exon30:c.C3000G:p.I1000M	20p12.2	C3L-03639	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	N	T	N	0.391	T	T	T	0.053	0.238	0.375	0.299	T	T	T	T	T	D	1.520	15.870	0.964	D	N	-0.480	1.217	-0.310	1.544	1.000	0.706	0.233	0.710	0.621	.	4.900	2.630	3.431	-0.562	-0.685	1.000	0.995	0.993	786	.	.	.	.	PLCB4	227	0	278	32	0.103225806451613	TRUE	TRUE
ENSG00000260903.3	.	BCM	GRCh38.p13	chr20	31996975	31996975	+	G	G	A	Missense_Mutation	SNP	ENST00000562532.3	exon3	c.G1258A	p.V420I	exonic	ENSG00000260903.3	.	nonsynonymous SNV	ENSG00000260903.3:ENST00000562532.3:exon3:c.G1258A:p.V420I	20q11.21	C3L-03639	.	.	.	.	.	.	.	.	.	5.17	.	T	P	B	D	D	L	.	.	0.207	T	T	T	0.150	0.560	0.043	.	T	T	T	T	D	T	2.260	21.300	0.990	D	D	0.248	3.520	0.305	3.746	0.969	0.646	0.590	0.645	0.542	.	5.020	5.020	3.841	1.172	0.672	1.000	0.995	0.930	499	.	.	.	ID=COSV73813507;OCCURENCE=1(large_intestine),1(lung)	XKR7	280	0	535	100	0.15748031496063	TRUE	TRUE
ENSG00000101162.4	.	BCM	GRCh38.p13	chr20	59023767	59023767	+	G	G	A	Missense_Mutation	SNP	ENST00000217133.2	exon4	c.G340A	p.E114K	exonic	ENSG00000101162.4	.	nonsynonymous SNV	ENSG00000101162.4:ENST00000217133.2:exon4:c.G340A:p.E114K	20q13.32	C3L-03639	0.0001	9.617e-05	0	0	0	5.993e-05	0	0.0007	rs200931731	11.20	D	D	D	B	D	D	H	T	N	0.302	D	T	D	0.427	.	0.836	0.271	T	T	T	T	T	D	2.680	22.800	0.998	D	D	0.363	4.125	0.219	3.275	1.000	0.498	0.380	0.573	0.711	.	5.390	4.430	8.124	0.189	0.676	1.000	0.002	0.002	973	Tubulin/FtsZ,_GTPase_domain	.	.	.	TUBB1	212	0	320	71	0.181585677749361	TRUE	NA
ENSG00000221890.5	.	BCM	GRCh38.p13	chr22	38843830	38843830	+	G	G	C	Missense_Mutation	SNP	ENST00000333039.3	exon1	c.C29G	p.A10G	exonic	ENSG00000221890.5	.	nonsynonymous SNV	ENSG00000221890.5:ENST00000333039.3:exon1:c.C29G:p.A10G	22q13.1	C3L-03639	.	.	.	.	.	.	.	.	.	7.18	D	D	D	D	.	.	L	T	N	0.172	T	T	D	0.109	0.365	0.285	.	T	T	T	T	D	T	3.795	25.800	0.982	D	N	0.217	3.381	0.093	2.705	1.000	0.437	0.578	0.504	0.604	.	1.470	1.470	1.961	0.068	0.441	0.980	0.993	0.997	764	.	.	.	.	NPTXR	42	0	78	14	0.152173913043478	TRUE	TRUE
ENSG00000182872.16	.	BCM	GRCh38.p13	chrX	47176587	47176587	+	G	G	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000182872.16	ENST00000377604.8:exon7:c.663+1G>C	.	.	Xp11.3	C3L-03639	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.570	34	0.995	D	.	.	.	.	.	1.000	.	.	.	.	0.974	4.720	4.720	9.728	1.166	0.663	1.000	1.000	0.997	332	.	.	.	.	RBM10	224	0	202	120	0.372670807453416	TRUE	TRUE
ENSG00000142611.17	.	BCM	GRCh38.p13	chr1	3186327	3186327	+	C	C	T	Silent	SNP	ENST00000270722.10	exon2	c.C240T	p.I80I	exonic	ENSG00000142611.17	.	synonymous SNV	ENSG00000142611.17:ENST00000270722.10:exon2:c.C240T:p.I80I	1p36.32	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRDM16	89	0	172	35	0.169082125603865	TRUE	TRUE
ENSG00000065526.12	.	BCM	GRCh38.p13	chr1	15934232	15934232	+	G	G	A	Silent	SNP	ENST00000375759.8	exon11	c.G7992A	p.P2664P	exonic	ENSG00000065526.12	.	synonymous SNV	ENSG00000065526.12:ENST00000375759.8:exon11:c.G7992A:p.P2664P	1p36.13	C3L-03639	5.774e-05	0	0.0006	0	0	0	0	0	rs757330925	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SPEN	222	1	354	93	0.208053691275168	TRUE	NA
ENSG00000184313.20	.	BCM	GRCh38.p13	chr1	54679980	54679980	+	C	C	G	Silent	SNP	ENST00000414150.6	exon13	c.C2316G	p.L772L	exonic	ENSG00000184313.20;ENSG00000271723.5	.	synonymous SNV	ENSG00000271723.5:ENST00000414150.6:exon13:c.C2316G:p.L772L,ENSG00000184313.20:ENST00000421030.7:exon13:c.C2316G:p.L772L	1p32.3	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MROH7	282	0	439	80	0.154142581888247	TRUE	TRUE
ENSG00000157064.11	.	BCM	GRCh38.p13	chr1	183293744	183293744	+	G	G	A	Silent	SNP	ENST00000287713.7	exon2	c.C135T	p.G45G	exonic	ENSG00000157064.11	.	synonymous SNV	ENSG00000157064.11:ENST00000287713.7:exon2:c.C135T:p.G45G	1q25.3	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54270332;OCCURENCE=1(pancreas),1(endometrium)	NMNAT2	287	0	376	27	0.0669975186104218	TRUE	TRUE
ENSG00000136002.19	.	BCM	GRCh38.p13	chr2	131038855	131038855	+	C	C	T	Silent	SNP	ENST00000326016.10	exon6	c.C570T	p.L190L	exonic	ENSG00000136002.19	.	synonymous SNV	ENSG00000136002.19:ENST00000326016.10:exon6:c.C570T:p.L190L	2q21.1	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARHGEF4	82	0	114	8	0.0655737704918033	TRUE	TRUE
ENSG00000004399.12	.	BCM	GRCh38.p13	chr3	129571196	129571196	+	G	G	A	Silent	SNP	ENST00000324093.8	exon18	c.C3444T	p.D1148D	exonic	ENSG00000004399.12	.	synonymous SNV	ENSG00000004399.12:ENST00000324093.8:exon18:c.C3444T:p.D1148D	3q22.1	C3L-03639	0.0033	9.647e-05	8.639e-05	0	0	3e-05	0.0022	0.0240	rs148029269	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLXND1	621	0	799	204	0.203389830508475	TRUE	NA
ENSG00000152977.10	.	BCM	GRCh38.p13	chr3	147410232	147410232	+	C	C	T	Silent	SNP	ENST00000282928.5	exon1	c.C120T	p.F40F	exonic	ENSG00000152977.10	.	synonymous SNV	ENSG00000152977.10:ENST00000282928.5:exon1:c.C120T:p.F40F	3q24	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV51551108;OCCURENCE=1(large_intestine)	ZIC1	326	0	492	103	0.173109243697479	TRUE	TRUE
ENSG00000090402.8	.	BCM	GRCh38.p13	chr3	165043068	165043068	+	G	G	A	Silent	SNP	ENST00000264382.8	exon17	c.C1995T	p.D665D	exonic	ENSG00000090402.8	.	synonymous SNV	ENSG00000090402.8:ENST00000264382.8:exon17:c.C1995T:p.D665D	3q26.1	C3L-03639	1.653e-05	0	0.0002	0	0	0	0	0	rs757380218	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52272737;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	SI	266	1	208	42	0.168	TRUE	TRUE
ENSG00000137462.8	.	BCM	GRCh38.p13	chr4	153703993	153703993	+	A	A	G	Silent	SNP	ENST00000260010.6	exon1	c.A1086G	p.L362L	exonic	ENSG00000137462.8	.	synonymous SNV	ENSG00000137462.8:ENST00000260010.6:exon1:c.A1086G:p.L362L	4q31.3	C3L-03639	8.334e-06	0	0	0.0001	0	0	0	0	rs765818382	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TLR2	141	0	145	45	0.236842105263158	TRUE	NA
ENSG00000164393.8	.	BCM	GRCh38.p13	chr6	47681807	47681807	+	C	C	A	Silent	SNP	ENST00000296862.5	exon6	c.C1248A	p.S416S	exonic	ENSG00000164393.8	.	synonymous SNV	ENSG00000164393.8:ENST00000296862.5:exon6:c.C1248A:p.S416S	6p12.3	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADGRF2	194	0	292	19	0.0610932475884244	TRUE	TRUE
ENSG00000047936.10	.	BCM	GRCh38.p13	chr6	117365695	117365695	+	C	C	T	Silent	SNP	ENST00000368508.7	exon19	c.G2859A	p.E953E	exonic	ENSG00000047936.10	.	synonymous SNV	ENSG00000047936.10:ENST00000368508.7:exon19:c.G2859A:p.E953E	6q22.1	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ROS1	87	0	68	27	0.284210526315789	TRUE	TRUE
ENSG00000266524.3	.	BCM	GRCh38.p13	chr10	47310040	47310040	+	C	C	T	Silent	SNP	ENST00000580279.2	exon2	c.C564T	p.R188R	exonic	ENSG00000266524.3	.	synonymous SNV	ENSG00000266524.3:ENST00000580279.2:exon2:c.C564T:p.R188R	10q11.22	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GDF10	125	0	173	41	0.191588785046729	TRUE	TRUE
ENSG00000204130.13	.	BCM	GRCh38.p13	chr10	68396785	68396785	+	G	G	C	Silent	SNP	ENST00000602465.5	exon4	c.C393G	p.L131L	exonic	ENSG00000204130.13	.	synonymous SNV	ENSG00000204130.13:ENST00000602465.5:exon4:c.C393G:p.L131L	10q21.3	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RUFY2	142	0	201	15	0.0694444444444444	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11781121	11781121	+	C	C	T	Silent	SNP	ENST00000262442.9	exon39	c.C7665T	p.Y2555Y	exonic	ENSG00000007174.18	.	synonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon39:c.C7665T:p.Y2555Y	17p12	C3L-03639	5.002e-05	0	0	0.0002	0	6.064e-05	0	0	rs529737124	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH9	175	0	250	33	0.11660777385159	TRUE	NA
ENSG00000130881.14	.	BCM	GRCh38.p13	chr19	33206727	33206727	+	G	G	A	Silent	SNP	ENST00000253193.9	exon6	c.G1719A	p.A573A	exonic	ENSG00000130881.14	.	synonymous SNV	ENSG00000130881.14:ENST00000253193.9:exon6:c.G1719A:p.A573A	19q13.11	C3L-03639	0.0002	9.833e-05	8.723e-05	0	0.0017	0.0001	0.0013	0.0001	rs148993115	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRP3	21	0	32	4	0.111111111111111	TRUE	NA
ENSG00000198300.14	.	BCM	GRCh38.p13	chr19	56817233	56817233	+	C	C	T	Silent	SNP	ENST00000326441.15	exon10	c.G1209A	p.S403S	exonic	ENSG00000198300.14	.	synonymous SNV	ENSG00000198300.14:ENST00000326441.15:exon10:c.G1209A:p.S403S	19q13.43	C3L-03639	1.651e-05	0	8.637e-05	0.0001	0	0	0	0	rs751816891	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV55626305;OCCURENCE=1(skin),1(lung),1(endometrium)	PEG3	237	0	268	75	0.21865889212828	TRUE	TRUE
ENSG00000215568.9	.	BCM	GRCh38.p13	chr22	16969953	16969953	+	C	C	T	Silent	SNP	ENST00000400588.5	exon4	c.G927A	p.A309A	exonic	ENSG00000215568.9	.	synonymous SNV	ENSG00000215568.9:ENST00000400588.5:exon4:c.G927A:p.A309A	22q11.1	C3L-03639	5.795e-05	0.0002	0	0.0003	0	0	0	0.0001	rs756284558	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GAB4	374	2	454	210	0.316265060240964	TRUE	NA
ENSG00000249592.6	.	BCM	GRCh38.p13	chr4	781196	781196	+	A	A	C	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000249592.6	.	.	.	4p16.3	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC139887.2	13	0	19	20	0.512820512820513	TRUE	NA
ENSG00000207692.3	.	BCM	GRCh38.p13	chr7	127058102	127058102	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000207692.3	.	.	.	7q31.33	C3L-03639	.	.	.	.	.	.	.	.	rs1027479075	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR592	116	0	165	28	0.145077720207254	TRUE	NA
ENSG00000197558.13	.	BCM	GRCh38.p13	chr7	149819419	149819419	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000197558.13	.	.	.	7q36.1	C3L-03639	0.0005	0	0	0	0	0.0009	0.0015	0	rs376818048	2.6	.	D	.	.	.	.	.	.	.	0.395	.	.	.	.	.	0.165	.	T	.	T	T	.	T	3.548	24.900	0.892	D	.	.	.	.	.	0.920	0.056	0.063	0.072	0.079	0.812	4.050	3.150	1.302	0.074	0.599	0.349	0.795	0.595	982	.	.	.	ID=COSV100946961;OCCURENCE=1(pancreas)	SSPO	204	0	425	46	0.0976645435244161	TRUE	NA
ENSG00000095777.17	.	BCM	GRCh38.p13	chr10	26212026	26212026	+	A	A	C	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000095777.17	ENST00000642920.2:c.*63A>C	.	.	10p12.1	C3L-03639	.	.	.	.	.	.	.	.	.	2.16	D	.	B	B	.	N	.	T	N	0.266	T	T	D	0.117	0.446	0.173	.	.	T	T	T	T	T	0.136	2.431	0.510	N	N	-0.891	0.531	-0.958	0.542	0.789	0.443	0.563	0.666	0.564	.	4.460	0.875	-0.430	0.186	0.756	0.000	0.002	0.007	670	.	.	.	.	MYO3A	54	0	134	13	0.0884353741496599	TRUE	TRUE
ENSG00000139910.20	.	BCM	GRCh38.p13	chr14	26472253	26472253	+	-	NA	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000139910.20	.	.	.	14q12	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NOVA1	NA	NA	NA	NA	NA	NA	NA
ENSG00000168746.8	.	BCM	GRCh38.p13	chr20	44461944	44461944	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000168746.8	.	.	.	20q13.12	C3L-03639	0.0073	0	0.0156	0	0	0.0048	0	0.0100	rs180762562	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC01620	219	0	355	34	0.0874035989717224	TRUE	NA
ENSG00000242520.5	.	BCM	GRCh38.p13	chrX	152115177	152115177	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000242520.5;ENSG00000266560.5	.	.	.	Xq28	C3L-03639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAGEA5	175	0	125	203	0.61890243902439	TRUE	NA
ENSG00000196182.11	.	BCM	GRCh38.p13	chr1	36341850	36341850	+	C	C	T	Missense_Mutation	SNP	ENST00000373132.4	exon11	c.G1213A	p.G405S	exonic	ENSG00000196182.11	.	nonsynonymous SNV	ENSG00000196182.11:ENST00000373132.4:exon11:c.G1213A:p.G405S	1p34.3	C3N-04282	1.659e-05	9.682e-05	0	0	0	1.511e-05	0	0	rs200773119	7.20	T	T	D	B	D	D	L	T	N	0.659	T	T	D	0.164	.	0.375	0.618	T	T	T	T	T	D	2.302	21.600	0.990	D	D	0.146	3.071	0.232	3.345	1.000	0.707	0.702	0.725	0.636	.	5.180	5.180	7.489	1.010	0.580	1.000	0.928	0.836	120	.	.	.	ID=COSV63735707;OCCURENCE=1(large_intestine)	STK40	301	0	426	96	0.183908045977011	TRUE	TRUE
ENSG00000066557.6	.	BCM	GRCh38.p13	chr1	70152466	70152466	+	C	C	A	Missense_Mutation	SNP	ENST00000370952.4	exon12	c.G1406T	p.C469F	exonic	ENSG00000066557.6	.	nonsynonymous SNV	ENSG00000066557.6:ENST00000370952.4:exon12:c.G1406T:p.C469F	1p31.1	C3N-04282	.	.	.	.	.	.	.	.	.	11.20	D	T	D	P	D	D	M	T	D	0.697	T	T	D	0.243	0.504	0.805	0.377	T	T	D	T	D	T	3.648	25.200	0.991	D	D	0.464	4.767	0.506	5.218	1.000	0.732	0.744	0.710	0.613	.	5.550	5.550	4.476	0.929	0.599	0.994	0.993	0.996	899	.	.	.	.	LRRC40	83	0	193	25	0.114678899082569	TRUE	TRUE
ENSG00000197915.7	.	BCM	GRCh38.p13	chr1	152216060	152216060	+	T	T	G	Missense_Mutation	SNP	ENST00000368801.4	exon3	c.A5569C	p.S1857R	exonic	ENSG00000197915.7	.	nonsynonymous SNV	ENSG00000197915.7:ENST00000368801.4:exon3:c.A5569C:p.S1857R	1q21.3	C3N-04282	.	.	.	.	.	.	.	.	.	2.19	T	D	B	B	.	N	M	T	N	0.236	T	T	T	0.018	0.306	0.175	.	T	T	T	T	T	T	0.048	1.663	0.474	N	N	-1.557	0.065	-1.682	0.055	0.022	0.554	0.852	0.574	0.621	.	3.930	-6.460	-2.475	-0.698	-0.156	0.000	0.000	0.003	568	.	.	.	.	HRNR	1660	1	2766	147	0.0504634397528321	NA	TRUE
ENSG00000162849.16	.	BCM	GRCh38.p13	chr1	245688799	245688799	+	C	C	G	Missense_Mutation	SNP	ENST00000407071.7	exon12	c.C5816G	p.S1939C	exonic	ENSG00000162849.16	.	nonsynonymous SNV	ENSG00000162849.16:ENST00000407071.7:exon12:c.C5816G:p.S1939C	1q44	C3N-04282	.	.	.	.	.	.	.	.	.	7.19	D	D	P	B	.	D	M	T	D	0.272	D	T	D	0.262	0.223	0.316	0.294	T	T	T	T	T	T	2.554	22.500	0.904	N	N	0.017	2.573	-0.060	2.165	0.997	0.706	0.710	0.607	0.563	.	5.330	5.330	1.877	0.866	0.505	0.446	0.125	0.062	965	.	.	.	.	KIF26B	85	0	106	31	0.226277372262774	TRUE	TRUE
ENSG00000144028.15	.	BCM	GRCh38.p13	chr2	96281896	96281896	+	G	G	A	Missense_Mutation	SNP	ENST00000323853.10	exon35	c.C4942T	p.R1648W	exonic	ENSG00000144028.15	.	nonsynonymous SNV	ENSG00000144028.15:ENST00000323853.10:exon35:c.C4942T:p.R1648W	2q11.2	C3N-04282	1.648e-05	0	0	0	0	2.998e-05	0	0	rs377595031	19.20	D	D	D	D	D	D	M	T	D	0.935	D	D	D	0.781	.	0.849	2.143	D	D	D	D	D	D	4.293	29.500	0.999	D	D	0.730	7.561	0.639	6.750	0.999	0.707	0.702	0.725	0.711	.	5.320	3.400	5.106	1.176	0.676	1.000	1.000	1.000	291	Helicase,_C-terminal	.	.	ID=COSV100108041;OCCURENCE=1(lung)	SNRNP200	195	0	286	73	0.203342618384401	TRUE	NA
ENSG00000138439.12	.	BCM	GRCh38.p13	chr2	202726233	202726258	+	TATTTTTGCTTTCTCAGATTGCAAAA	TATTTTTGCTTTCTCAGATTGCAAAA	-	In_Frame_Del	DEL	ENST00000392238.3	exon4	c.847_855del	p.I283_K285del	exonic	ENSG00000138439.12	.	nonframeshift deletion	ENSG00000138439.12:ENST00000392238.3:exon4:c.847_855del:p.I283_K285del	2q33.2	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FAM117B	196	0	217	89	0.290849673202614	NA	TRUE
ENSG00000123989.14	.	BCM	GRCh38.p13	chr2	219543331	219543331	+	C	C	G	Missense_Mutation	SNP	ENST00000243776.11	exon1	c.G208C	p.E70Q	exonic	ENSG00000123989.14	.	nonsynonymous SNV	ENSG00000123989.14:ENST00000243776.11:exon1:c.G208C:p.E70Q	2q35	C3N-04282	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	N	N	N	T	N	0.148	T	T	D	0.022	0.135	0.354	0.830	D	T	T	T	T	T	2.072	19.800	0.871	N	N	-0.726	0.770	-0.670	0.943	1.000	0.726	0.594	0.522	0.568	.	3.090	1.170	0.479	0.954	0.459	0.072	0.964	0.904	115	.	.	.	.	CHPF	233	0	318	69	0.178294573643411	TRUE	TRUE
ENSG00000132182.12	.	BCM	GRCh38.p13	chr3	13319958	13319958	+	C	C	T	Missense_Mutation	SNP	ENST00000254508.7	exon37	c.G5188A	p.V1730M	exonic	ENSG00000132182.12	.	nonsynonymous SNV	ENSG00000132182.12:ENST00000254508.7:exon37:c.G5188A:p.V1730M	3p25.1	C3N-04282	1.675e-05	0	0	0.0001	0	1.527e-05	0	0	rs773034259	7.20	D	D	D	P	N	D	M	T	N	0.455	T	T	T	0.149	.	0.409	0.483	T	T	T	T	T	D	3.016	23.400	0.996	D	N	0.135	3.026	0.066	2.597	0.695	0.745	0.702	0.732	0.655	.	5.660	4.790	1.844	1.026	0.599	0.936	0.003	0.001	878	.	.	.	ID=COSV54404122;OCCURENCE=1(large_intestine)	NUP210	244	0	370	135	0.267326732673267	TRUE	TRUE
ENSG00000114529.12	.	BCM	GRCh38.p13	chr3	112109567	112109567	+	C	C	G	Missense_Mutation	SNP	ENST00000264848.9	exon4	c.C421G	p.P141A	exonic	ENSG00000114529.12	.	nonsynonymous SNV	ENSG00000114529.12:ENST00000264848.9:exon4:c.C421G:p.P141A	3q13.2	C3N-04282	.	.	.	.	.	.	.	.	.	5.14	T	D	.	.	D	D	.	T	D	0.328	T	T	T	0.166	0.278	0.136	.	.	.	T	T	D	.	1.167	13.370	0.992	N	N	0.294	3.750	0.151	2.952	1.000	0.615	0.588	0.659	0.568	.	4.990	4.990	1.706	1.010	0.580	0.292	0.451	0.876	830	.	.	.	.	C3orf52	112	0	190	52	0.214876033057851	TRUE	NA
ENSG00000114019.14	.	BCM	GRCh38.p13	chr3	134367549	134367549	+	C	C	T	Missense_Mutation	SNP	ENST00000422605.6	exon3	c.G989A	p.R330Q	exonic	ENSG00000114019.14	.	nonsynonymous SNV	ENSG00000114019.14:ENST00000422605.6:exon3:c.G989A:p.R330Q	3q22.2	C3N-04282	8.331e-06	0	0	0	0	1.518e-05	0	0	rs756431790	3.20	T	T	B	B	D	D	L	T	N	0.171	T	T	T	0.034	.	0.218	0.158	T	T	T	T	T	D	1.807	17.780	0.999	N	N	-0.596	0.994	-0.497	1.207	1.000	0.778	0.616	0.854	0.735	.	5.360	2.080	-0.379	0.949	0.524	0.016	0.993	0.995	768	.	.	.	.	AMOTL2	526	0	707	253	0.263541666666667	TRUE	NA
ENSG00000047662.5	.	BCM	GRCh38.p13	chr4	17709488	17709488	+	G	G	A	Missense_Mutation	SNP	ENST00000265018.4	exon2	c.C298T	p.R100C	exonic	ENSG00000047662.5	.	nonsynonymous SNV	ENSG00000047662.5:ENST00000265018.4:exon2:c.C298T:p.R100C	4p15.31	C3N-04282	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	N	D	M	T	D	0.303	D	D	D	0.516	.	0.513	.	T	T	D	D	D	D	4.435	31	0.999	D	D	0.708	7.239	0.672	7.258	1.000	0.554	0.588	0.573	0.564	.	4.650	4.650	8.320	1.176	0.676	1.000	0.342	0.917	790	Protein_FAM184A/B,_N-terminal	.	.	ID=COSV53958874;OCCURENCE=1(breast)	FAM184B	141	0	225	86	0.276527331189711	TRUE	TRUE
ENSG00000145147.20	.	BCM	GRCh38.p13	chr4	20523888	20523888	+	G	G	A	Missense_Mutation	SNP	ENST00000504154.6	exon13	c.G1259A	p.R420Q	exonic	ENSG00000145147.20	.	nonsynonymous SNV	ENSG00000145147.20:ENST00000504154.6:exon13:c.G1259A:p.R420Q	4p15.31	C3N-04282	8.238e-06	0	0	0	0	1.499e-05	0	0	rs749945090	9.20	T	T	D	B	D	D	N	T	N	0.908	T	T	T	0.297	0.397	0.847	1.069	T	T	D	D	D	D	3.656	25.200	0.999	D	D	0.288	3.715	0.436	4.626	1.000	0.706	0.574	0.653	0.613	.	5.300	5.300	9.985	1.176	0.676	1.000	0.999	0.998	853	.	.	.	.	SLIT2	165	0	272	90	0.248618784530387	TRUE	NA
ENSG00000113088.6	.	BCM	GRCh38.p13	chr5	55024807	55024807	+	G	G	A	Missense_Mutation	SNP	ENST00000231009.3	exon2	c.G212A	p.R71Q	exonic	ENSG00000113088.6	.	nonsynonymous SNV	ENSG00000113088.6:ENST00000231009.3:exon2:c.G212A:p.R71Q	5q11.2	C3N-04282	0.0006	9.707e-05	0.0004	0	0	4.562e-05	0	0.0039	rs559900915	1.20	T	T	B	B	N	N	L	D	N	0.135	T	T	T	0.215	0.402	0.554	0.048	T	T	T	T	T	T	1.369	14.870	0.770	N	N	-1.892	0.015	-1.870	0.025	0.001	0.516	0.610	0.574	0.613	.	4.550	-1.730	-1.011	-0.130	-0.854	0.000	0.002	0.000	477	Serine_proteases,_trypsin_domain	.	.	.	GZMK	39	0	63	10	0.136986301369863	TRUE	NA
ENSG00000171617.14	.	BCM	GRCh38.p13	chr5	74636343	74636343	+	A	A	T	Missense_Mutation	SNP	ENST00000651128.1	exon3	c.T143A	p.V48D	exonic	ENSG00000171617.14	.	nonsynonymous SNV	ENSG00000171617.14:ENST00000651128.1:exon3:c.T143A:p.V48D	5q13.3	C3N-04282	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	T	D	0.960	D	D	D	0.936	0.847	0.879	2.504	D	D	D	D	D	D	4.289	29.500	0.940	D	D	1.071	16.334	0.977	17.493	1.000	0.722	0.699	0.710	0.735	.	5.740	5.740	9.325	1.312	0.756	1.000	0.810	0.951	428	BTB/POZ_domain	.	.	.	ENC1	340	0	348	129	0.270440251572327	TRUE	TRUE
ENSG00000204956.5	.	BCM	GRCh38.p13	chr5	141331611	141331611	+	C	C	A	Missense_Mutation	SNP	ENST00000517417.2	exon1	c.C927A	p.F309L	exonic	ENSG00000204956.5	.	nonsynonymous SNV	ENSG00000204956.5:ENST00000517417.2:exon1:c.C927A:p.F309L	5q31.3	C3N-04282	.	.	.	.	.	.	.	.	.	5.19	D	D	P	P	N	N	M	T	D	0.551	T	T	T	0.139	0.629	0.323	0.582	.	T	T	T	D	T	0.303	4.325	0.991	N	N	-0.441	1.296	-0.667	0.947	0.960	0.549	0.574	0.547	0.616	.	3.990	-5.810	-1.513	-4.327	-2.735	0.000	0.269	0.807	472	Cadherin-like	.	.	.	PCDHGA1	122	0	168	60	0.263157894736842	TRUE	TRUE
ENSG00000146963.18	.	BCM	GRCh38.p13	chr7	139409602	139409602	+	C	C	G	Missense_Mutation	SNP	ENST00000354926.9	exon7	c.C727G	p.R243G	exonic	ENSG00000146963.18;ENSG00000269955.2	.	nonsynonymous SNV	ENSG00000146963.18:ENST00000354926.9:exon7:c.C727G:p.R243G,ENSG00000269955.2:ENST00000541515.3:exon8:c.C925G:p.R309G	7q34	C3N-04282	.	.	.	.	.	.	.	.	.	10.18	D	T	D	D	D	.	L	T	D	0.381	T	T	D	0.161	0.404	0.151	2.969	.	T	T	T	D	D	3.770	25.700	0.997	D	D	0.630	6.240	0.598	6.198	0.868	0.732	0.725	0.744	0.714	.	4.890	4.890	2.680	1.007	0.589	1.000	0.998	0.994	834	.	.	.	.	LUC7L2	87	0	172	39	0.184834123222749	TRUE	TRUE
ENSG00000257743.8	.	BCM	GRCh38.p13	chr7	142186004	142186004	+	G	G	A	Missense_Mutation	SNP	ENST00000477922.3	exon35	c.G4003A	p.V1335I	exonic	ENSG00000257743.8	.	nonsynonymous SNV	ENSG00000257743.8:ENST00000477922.3:exon35:c.G4003A:p.V1335I	7q34	C3N-04282	.	.	.	.	.	.	.	.	rs937654142	4.11	.	D	.	.	D	.	.	.	.	0.146	T	T	T	0.207	.	0.055	.	.	T	T	T	D	.	2.622	22.700	0.998	D	N	-0.021	2.438	-0.066	2.148	1.000	0.487	0.563	0.574	0.564	.	4.800	3.920	1.937	1.176	0.676	0.144	0.542	0.818	934	.	.	.	ID=COSV72176648;OCCURENCE=1(ovary),2(skin)	MGAM2	111	0	197	64	0.245210727969349	TRUE	TRUE
ENSG00000129696.13	.	BCM	GRCh38.p13	chr8	33512031	33512031	+	C	C	G	Missense_Mutation	SNP	ENST00000431156.7	exon2	c.G583C	p.E195Q	exonic	ENSG00000129696.13	.	nonsynonymous SNV	ENSG00000129696.13:ENST00000431156.7:exon2:c.G583C:p.E195Q	8p12	C3N-04282	.	.	.	.	.	.	.	.	.	4.20	D	T	P	B	N	N	M	T	N	0.243	T	T	D	0.316	0.437	0.408	0.476	T	T	T	T	D	T	1.940	18.790	0.989	N	N	-0.191	1.903	-0.284	1.597	1.000	0.660	0.587	0.663	0.639	.	4.660	3.780	1.276	0.129	-0.182	0.348	0.457	0.515	863	.	.	.	.	TTI2	344	0	401	200	0.332778702163062	TRUE	TRUE
ENSG00000182674.6	.	BCM	GRCh38.p13	chr8	72936799	72936799	+	G	G	A	Missense_Mutation	SNP	ENST00000523207.2	exon3	c.G1444A	p.A482T	exonic	ENSG00000182674.6	.	nonsynonymous SNV	ENSG00000182674.6:ENST00000523207.2:exon3:c.G1444A:p.A482T	8q21.11	C3N-04282	1.65e-05	0	0	0	0	3.001e-05	0	0	rs770363006	0.20	T	T	B	B	N	N	N	T	N	0.012	T	T	T	0.093	0.368	0.420	0.539	T	T	T	T	T	T	0.128	2.353	0.735	N	N	-1.060	0.343	-1.041	0.440	0.000	0.554	0.547	0.602	0.564	.	5.470	-0.202	-0.227	1.176	0.676	0.000	0.076	0.285	847	.	.	.	ID=COSV73050496;OCCURENCE=1(large_intestine)	KCNB2	135	0	224	107	0.323262839879154	TRUE	TRUE
ENSG00000154493.19	.	BCM	GRCh38.p13	chr10	126459124	126459124	+	G	G	A	Missense_Mutation	SNP	ENST00000284694.11	exon6	c.C1813T	p.R605W	exonic	ENSG00000154493.19	.	nonsynonymous SNV	ENSG00000154493.19:ENST00000284694.11:exon6:c.C1813T:p.R605W	10q26.2	C3N-04282	5.766e-05	0	0	0	0	2.997e-05	0	0.0003	rs756021619	9.19	D	D	D	P	N	N	L	T	D	0.487	T	T	D	0.223	.	0.534	0.276	.	T	T	T	D	D	4.097	27.700	0.999	D	D	0.479	4.873	0.443	4.679	1.000	0.487	0.574	0.574	0.564	.	4.950	4.000	4.588	1.157	0.654	1.000	0.039	0.085	623	ALMS_motif	.	.	ID=COSV99504737;OCCURENCE=1(breast)	C10orf90	275	1	504	125	0.19872813990461	TRUE	NA
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25227341	25227341	+	T	T	G	Missense_Mutation	SNP	ENST00000256078.10	exon3	c.A183C	p.Q61H	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon3:c.A183C:p.Q61H	12p12.1	C3N-04282	.	.	.	.	.	.	.	.	rs17851045	17.20	D	D	B	B	D	D	M	D	D	0.760	D	D	D	0.644	0.659	0.905	1.857	D	D	D	D	D	T	2.993	23.400	0.997	D	D	0.298	3.768	0.383	4.239	0.998	0.722	0.710	0.710	0.735	.	5.770	5.770	2.812	1.120	0.644	1.000	1.000	1.000	855	Small_GTP-binding_protein_domain	.	.	ID=COSV55498802;OCCURENCE=2(breast),6(liver),1(genital_tract),1(cervix),117(large_intestine),2(central_nervous_system),17(biliary_tract),3(ovary),8(stomach),50(haematopoietic_and_lymphoid_tissue),2(urinary_tract),1(kidney),71(pancreas),2(skin),2(prostate),28(lung),1(thyroid),2(small_intestine),5(endometrium)	KRAS	172	0	199	163	0.450276243093923	TRUE	TRUE
ENSG00000189079.17	.	BCM	GRCh38.p13	chr12	45837391	45837391	+	C	C	-	Nonsense_Mutation	SNP	ENST00000334344.11	exon9	c.1094delC	p.S365*	exonic	ENSG00000189079.17	.	stopgain	ENSG00000189079.17:ENST00000334344.11:exon9:c.1094delC:p.S365*	12q12	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ARID2	45	0	58	42	0.42	TRUE	TRUE
ENSG00000100926.15	.	BCM	GRCh38.p13	chr14	24192840	24192840	+	G	G	A	Missense_Mutation	SNP	ENST00000261789.9	exon3	c.C775T	p.R259C	exonic	ENSG00000100926.15;ENSG00000254692.1	.	nonsynonymous SNV	ENSG00000100926.15:ENST00000261789.9:exon3:c.C775T:p.R259C,ENSG00000254692.1:ENST00000530611.1:exon7:c.C1402T:p.R468C	14q12	C3N-04282	8.263e-06	0	0	0	0	1.502e-05	0	0	rs759491065	17.19	D	D	D	D	D	D	H	T	D	0.893	D	D	D	0.771	0.843	0.909	1.514	D	T	D	D	D	.	4.426	31	0.999	D	D	0.823	9.250	0.695	7.666	1.000	0.707	0.702	0.702	0.714	.	5.100	4.210	4.196	1.176	0.676	1.000	1.000	0.999	895	.	.	.	ID=COSV55778221;OCCURENCE=2(large_intestine),1(endometrium)	TM9SF1	70	0	112	44	0.282051282051282	TRUE	TRUE
ENSG00000169783.12	.	BCM	GRCh38.p13	chr15	77614913	77614913	+	G	G	A	Missense_Mutation	SNP	ENST00000355300.6	exon2	c.C994T	p.R332C	exonic	ENSG00000169783.12	.	nonsynonymous SNV	ENSG00000169783.12:ENST00000355300.6:exon2:c.C994T:p.R332C	15q24.3	C3N-04282	8.367e-06	0	0	0	0	0	0	6.112e-05	rs758132909	12.20	D	D	D	P	D	D	L	T	D	0.759	T	T	D	0.324	0.639	0.378	2.079	T	T	T	D	D	D	3.757	25.600	0.999	D	D	0.528	5.262	0.553	5.683	0.999	0.707	0.588	0.725	0.568	.	5.080	5.080	5.170	1.172	0.672	1.000	0.998	0.993	0	.	.	.	ID=COSV62438690;OCCURENCE=1(large_intestine),1(skin)	LINGO1	213	0	371	122	0.247464503042596	TRUE	TRUE
ENSG00000122257.20	.	BCM	GRCh38.p13	chr16	24559539	24559539	+	C	C	-	Frame_Shift_Del	DEL	ENST00000319715.10	exon8	c.709delC	p.F238Sfs*29	exonic	ENSG00000122257.20	.	frameshift deletion	ENSG00000122257.20:ENST00000319715.10:exon8:c.709delC:p.F238Sfs*29	16p12.1	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RBBP6	78	0	98	47	0.324137931034483	TRUE	TRUE
ENSG00000178188.14	.	BCM	GRCh38.p13	chr16	28866399	28866399	+	C	C	T	Missense_Mutation	SNP	ENST00000322610.12	exon4	c.C305T	p.S102L	exonic	ENSG00000178188.14	.	nonsynonymous SNV	ENSG00000178188.14:ENST00000322610.12:exon4:c.C305T:p.S102L	16p11.2	C3N-04282	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	N	T	N	0.144	T	T	D	0.119	0.272	0.068	0.208	T	T	T	T	T	T	0.766	9.063	0.960	N	N	-0.747	0.735	-0.612	1.029	1.000	0.745	0.744	0.723	0.762	.	4.800	3.830	0.806	0.966	0.528	0.000	0.036	0.583	289	.	.	.	ID=COSV59466817;OCCURENCE=1(endometrium)	SH2B1	179	0	248	54	0.178807947019868	TRUE	TRUE
ENSG00000141013.17	.	BCM	GRCh38.p13	chr16	90043214	90043214	+	C	C	T	Missense_Mutation	SNP	ENST00000268699.9	exon11	c.C1306T	p.R436C	exonic	ENSG00000141013.17	.	nonsynonymous SNV	ENSG00000141013.17:ENST00000268699.9:exon11:c.C1306T:p.R436C	16q24.3	C3N-04282	0.0003	0.0005	0	0	0	0	0	0.0015	rs555627699	9.19	D	D	D	P	N	D	.	T	D	0.437	T	T	D	0.167	0.340	0.511	0.063	T	T	T	T	T	D	4.040	27.300	0.999	D	D	0.571	5.636	0.565	5.814	1.000	0.707	0.574	0.723	0.714	.	5.510	5.510	2.289	0.921	0.599	1.000	0.941	0.825	779	.	.	.	ID=COSV99243807;OCCURENCE=1(endometrium)	GAS8	80	0	90	27	0.230769230769231	TRUE	NA
ENSG00000185158.12	.	BCM	GRCh38.p13	chr17	32022046	32022046	+	G	G	T	Missense_Mutation	SNP	ENST00000394713.7	exon1	c.G900T	p.Q300H	exonic	ENSG00000185158.12	.	nonsynonymous SNV	ENSG00000185158.12:ENST00000394713.7:exon1:c.G900T:p.Q300H	17q11.2	C3N-04282	.	.	.	.	.	.	.	.	.	5.19	T	T	D	D	.	N	M	T	D	0.101	T	T	T	0.103	0.295	0.509	0.292	T	T	T	T	D	T	0.793	9.319	0.927	N	N	-0.628	0.938	-0.910	0.607	0.000	0.651	0.654	0.651	0.492	.	1.530	-1.270	-0.437	0.852	0.262	0.000	0.020	0.013	961	Leucine-rich_repeat-containing_protein_37,_N-terminal	.	.	.	LRRC37B	339	1	326	214	0.396296296296296	NA	TRUE
ENSG00000108883.13	.	BCM	GRCh38.p13	chr17	44862735	44862735	+	G	G	A	Missense_Mutation	SNP	ENST00000426333.7	exon16	c.C1585T	p.R529C	exonic	ENSG00000108883.13	.	nonsynonymous SNV	ENSG00000108883.13:ENST00000426333.7:exon16:c.C1585T:p.R529C	17q21.31	C3N-04282	.	.	.	.	.	.	.	.	rs376157050	19.20	D	D	D	D	D	D	H	T	D	0.840	D	D	D	0.425	.	0.546	1.784	D	D	D	D	D	D	4.439	31	0.999	D	D	0.998	13.850	0.953	16.217	1.000	0.722	0.702	0.725	0.735	.	6.160	6.160	6.242	1.176	0.676	1.000	1.000	0.997	560	Translation_elongation_factor_EFTu-like,_domain_2	.	.	ID=COSV101274541;OCCURENCE=1(upper_aerodigestive_tract)	EFTUD2	88	0	137	48	0.259459459459459	TRUE	NA
ENSG00000108375.12	.	BCM	GRCh38.p13	chr17	58360862	58360862	+	C	C	-	Frame_Shift_Del	DEL	ENST00000584437.5	exon6	c.770delG	p.G257Vfs*162	exonic	ENSG00000108375.12;ENSG00000285897.1	.	frameshift deletion	ENSG00000108375.12:ENST00000584437.5:exon6:c.770delG:p.G257Vfs*162,ENSG00000285897.1:ENST00000648873.1:exon6:c.770delG:p.G257Vfs*162	17q22	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF43	183	0	229	76	0.249180327868852	TRUE	TRUE
ENSG00000182687.4	.	BCM	GRCh38.p13	chr17	76076994	76076994	+	G	G	A	Missense_Mutation	SNP	ENST00000329003.4	exon2	c.G727A	p.A243T	exonic	ENSG00000182687.4	.	nonsynonymous SNV	ENSG00000182687.4:ENST00000329003.4:exon2:c.G727A:p.A243T	17q25.1	C3N-04282	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	L	T	N	0.093	T	T	T	0.054	0.509	0.409	.	T	T	T	T	T	D	2.546	22.500	0.995	D	N	-0.314	1.579	-0.307	1.550	1.000	0.765	0.628	0.607	0.621	.	4.850	2.600	2.907	1.172	0.672	0.223	0.951	0.993	676	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV57162907;OCCURENCE=3(stomach)	GALR2	256	0	374	126	0.252	TRUE	TRUE
ENSG00000105429.13	.	BCM	GRCh38.p13	chr19	42348404	42348404	+	G	G	A	Missense_Mutation	SNP	ENST00000251268.11	exon13	c.G2230A	p.V744M	exonic	ENSG00000105429.13	.	nonsynonymous SNV	ENSG00000105429.13:ENST00000251268.11:exon13:c.G2230A:p.V744M	19q13.2	C3N-04282	.	.	.	.	.	.	.	.	rs1015184528	4.20	T	T	B	B	D	D	N	T	N	0.141	T	T	D	0.031	0.227	0.143	.	T	T	T	T	T	T	1.885	18.370	0.990	D	N	-0.040	2.373	0.051	2.544	0.872	0.707	0.634	0.723	0.714	.	5.200	5.200	3.358	1.176	0.618	0.999	0.698	0.168	551	.	.	.	.	MEGF8	150	0	119	137	0.53515625	TRUE	NA
ENSG00000124225.16	.	BCM	GRCh38.p13	chr20	57652585	57652585	+	G	G	T	Missense_Mutation	SNP	ENST00000341744.8	exon4	c.C332A	p.A111D	exonic	ENSG00000124225.16	.	nonsynonymous SNV	ENSG00000124225.16:ENST00000341744.8:exon4:c.C332A:p.A111D	20q13.31	C3N-04282	.	.	.	.	.	.	.	.	.	7.20	T	T	P	B	D	D	M	T	N	0.508	T	T	D	0.106	0.244	0.214	1.320	T	T	T	T	D	T	2.665	22.800	0.981	D	D	0.201	3.308	0.264	3.513	1.000	0.707	0.610	0.723	0.714	.	5.320	5.320	4.368	1.176	0.618	0.997	0.931	0.846	865	.	.	.	.	PMEPA1	18	0	23	16	0.41025641025641	TRUE	TRUE
ENSG00000215440.12	.	BCM	GRCh38.p13	chr20	58701082	58701082	+	A	A	G	Missense_Mutation	SNP	ENST00000356091.11	exon6	c.A746G	p.D249G	exonic	ENSG00000215440.12	.	nonsynonymous SNV	ENSG00000215440.12:ENST00000356091.11:exon6:c.A746G:p.D249G	20q13.32	C3N-04282	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	N	N	T	D	0.278	T	T	T	0.105	0.341	0.428	0.306	T	T	T	T	D	D	2.546	22.500	0.943	D	D	-0.719	0.781	-0.615	1.023	1.000	0.732	0.644	0.723	0.728	.	5.100	4.000	5.451	1.312	-0.065	1.000	0.012	0.037	951	Peptidase_M17,_leucyl_aminopeptidase,_C-terminal	.	.	.	NPEPL1	178	0	259	36	0.122033898305085	TRUE	TRUE
ENSG00000100393.14	.	BCM	GRCh38.p13	chr22	41166634	41166634	+	G	G	T	Missense_Mutation	SNP	ENST00000263253.9	exon23	c.G3842T	p.R1281L	exonic	ENSG00000100393.14	.	nonsynonymous SNV	ENSG00000100393.14:ENST00000263253.9:exon23:c.G3842T:p.R1281L	22q13.2	C3N-04282	.	.	.	.	.	.	.	.	.	11.20	T	T	D	P	N	D	N	D	D	0.318	T	T	D	0.494	0.462	0.805	.	T	D	D	T	D	D	3.828	26.000	0.996	D	D	0.468	4.797	0.564	5.796	1.000	0.732	0.725	0.744	0.728	.	5.850	5.850	6.289	1.167	0.618	1.000	1.000	0.997	255	.	.	.	ID=COSV99607677;OCCURENCE=1(urinary_tract)	EP300	141	0	155	84	0.351464435146443	TRUE	TRUE
ENSG00000196576.15	.	BCM	GRCh38.p13	chr22	50286252	50286252	+	G	G	A	Nonsense_Mutation	SNP	ENST00000359337.9	exon9	c.C1798T	p.R600X	exonic	ENSG00000196576.15	.	stopgain	ENSG00000196576.15:ENST00000359337.9:exon9:c.C1798T:p.R600X	22q13.33	C3N-04282	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	A	.	.	.	0.067	.	.	.	.	.	.	.	.	.	D	D	.	.	5.621	34	0.995	N	N	0.076	2.792	-0.297	1.569	0.992	0.672	0.702	0.723	0.711	.	4.010	1.610	-0.472	-0.192	0.618	0.000	0.000	0.001	616	.	.	.	ID=COSV63780558;OCCURENCE=1(oesophagus),1(large_intestine),1(upper_aerodigestive_tract)	PLXNB2	205	0	181	114	0.386440677966102	TRUE	TRUE
ENSG00000101850.13	.	BCM	GRCh38.p13	chrX	9765805	9765805	+	G	G	A	Missense_Mutation	SNP	ENST00000467482.6	exon1	c.C13T	p.R5C	exonic	ENSG00000101850.13	.	nonsynonymous SNV	ENSG00000101850.13:ENST00000467482.6:exon1:c.C13T:p.R5C	Xp22.2	C3N-04282	.	.	.	.	.	.	.	.	rs62635289	19.19	D	D	D	D	D	D	M	D	D	0.726	D	D	D	0.925	0.874	0.995	0.320	D	D	D	D	D	D	3.698	25.400	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.350	3.370	2.578	0.940	0.658	0.999	0.996	0.950	974	.	.	.	.	GPR143	58	0	41	44	0.517647058823529	TRUE	NA
ENSG00000094631.21	.	BCM	GRCh38.p13	chrX	48824601	48824601	+	C	C	T	Missense_Mutation	SNP	ENST00000334136.11	exon29	c.C3637T	p.H1213Y	exonic	ENSG00000094631.21	.	nonsynonymous SNV	ENSG00000094631.21:ENST00000334136.11:exon29:c.C3637T:p.H1213Y	Xp11.23	C3N-04282	.	.	.	.	.	.	.	.	.	2.19	T	T	P	B	N	N	M	T	N	0.165	T	T	D	0.039	0.275	0.666	0.067	T	T	T	T	T	T	0.663	8.110	0.994	N	.	.	.	.	.	0.009	.	.	.	.	.	5.310	3.410	0.785	1.022	0.596	0.003	0.999	0.972	7	.	.	.	.	HDAC6	63	0	50	75	0.6	TRUE	TRUE
ENSG00000089820.16	.	BCM	GRCh38.p13	chrX	153921447	153921447	+	G	G	A	Missense_Mutation	SNP	ENST00000350060.10	exon3	c.C353T	p.A118V	exonic	ENSG00000089820.16	.	nonsynonymous SNV	ENSG00000089820.16:ENST00000350060.10:exon3:c.C353T:p.A118V	Xq28	C3N-04282	0	0	0	0	0	0	0	0	rs142621606	6.19	D	D	P	P	N	N	M	T	D	0.400	T	T	T	0.081	0.471	0.344	1.205	T	T	T	T	D	D	2.098	20.000	0.998	N	.	.	.	.	.	1.000	.	.	.	.	.	4.800	2.840	1.322	0.196	-0.157	0.188	0.617	0.690	180	FCH_domain;F-BAR_domain	.	.	ID=COSV63131159;OCCURENCE=1(large_intestine)	ARHGAP4	89	0	81	126	0.608695652173913	TRUE	TRUE
ENSG00000162722.9	.	BCM	GRCh38.p13	chr1	247864821	247864821	+	G	G	A	Silent	SNP	ENST00000366481.4	exon3	c.G633A	p.T211T	exonic	ENSG00000162722.9	.	synonymous SNV	ENSG00000162722.9:ENST00000366481.4:exon3:c.G633A:p.T211T	1q44	C3N-04282	0.0005	0.0056	0.0003	0	0	3.179e-05	0	0	rs149673594	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63570480;OCCURENCE=1(breast),1(large_intestine),1(endometrium)	TRIM58	437	0	513	232	0.311409395973154	TRUE	TRUE
ENSG00000188219.14	.	BCM	GRCh38.p13	chr2	131264224	131264224	+	C	C	T	Silent	SNP	ENST00000356920.9	exon15	c.C2769T	p.F923F	exonic	ENSG00000188219.14	.	synonymous SNV	ENSG00000188219.14:ENST00000356920.9:exon15:c.C2769T:p.F923F	2q21.1	C3N-04282	6.769e-05	0.0001	8.639e-05	0	0	9.257e-05	0	0	rs745389252	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58228074;OCCURENCE=2(skin)	POTEE	1817	0	2638	220	0.0769769069279216	NA	TRUE
ENSG00000178057.15	.	BCM	GRCh38.p13	chr3	49022976	49022976	+	G	G	T	Silent	SNP	ENST00000326925.11	exon4	c.G438T	p.T146T	exonic	ENSG00000178057.15	.	synonymous SNV	ENSG00000178057.15:ENST00000326925.11:exon4:c.G438T:p.T146T	3p21.31	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NDUFAF3	327	0	469	181	0.278461538461538	TRUE	TRUE
ENSG00000138777.20	.	BCM	GRCh38.p13	chr4	105473973	105473973	+	G	G	C	Silent	SNP	ENST00000341695.10	exon1	c.C78G	p.T26T	exonic	ENSG00000138777.20	.	synonymous SNV	ENSG00000138777.20:ENST00000341695.10:exon1:c.C78G:p.T26T	4q24	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PPA2	172	0	253	41	0.139455782312925	TRUE	TRUE
ENSG00000164532.11	.	BCM	GRCh38.p13	chr7	35250100	35250100	+	G	G	A	Silent	SNP	ENST00000408931.4	exon2	c.C231T	p.S77S	exonic	ENSG00000164532.11	.	synonymous SNV	ENSG00000164532.11:ENST00000408931.4:exon2:c.C231T:p.S77S	7p14.2	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBX20	227	0	346	126	0.266949152542373	TRUE	TRUE
ENSG00000065675.15	.	BCM	GRCh38.p13	chr10	6515070	6515070	+	G	G	A	Silent	SNP	ENST00000263125.10	exon2	c.C66T	p.G22G	exonic	ENSG00000065675.15	.	synonymous SNV	ENSG00000065675.15:ENST00000263125.10:exon2:c.C66T:p.G22G	10p15.1	C3N-04282	1.649e-05	0	0	0	0	3.001e-05	0	0	rs762275564	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRKCQ	184	0	284	119	0.295285359801489	TRUE	NA
ENSG00000068383.19	.	BCM	GRCh38.p13	chr10	132726839	132726839	+	C	C	T	Silent	SNP	ENST00000368594.8	exon9	c.C666T	p.F222F	exonic	ENSG00000068383.19	.	synonymous SNV	ENSG00000068383.19:ENST00000368594.8:exon9:c.C666T:p.F222F	10q26.3	C3N-04282	0.0001	9.615e-05	0	0	0	0	0	0.0008	rs554890216	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	INPP5A	40	0	51	22	0.301369863013699	TRUE	NA
ENSG00000188906.16	.	BCM	GRCh38.p13	chr12	40278168	40278168	+	G	G	A	Silent	SNP	ENST00000298910.12	exon18	c.G2148A	p.A716A	exonic	ENSG00000188906.16	.	synonymous SNV	ENSG00000188906.16:ENST00000298910.12:exon18:c.G2148A:p.A716A	12q12	C3N-04282	3.295e-05	0	0	0	0	4.495e-05	0	6.056e-05	rs200459681	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LRRK2	316	1	263	230	0.466531440162272	TRUE	NA
ENSG00000064300.9	.	BCM	GRCh38.p13	chr17	49506315	49506315	+	C	C	T	Silent	SNP	ENST00000172229.8	exon3	c.C225T	p.D75D	exonic	ENSG00000064300.9	.	synonymous SNV	ENSG00000064300.9:ENST00000172229.8:exon3:c.C225T:p.D75D	17q21.33	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99412701;OCCURENCE=1(prostate)	NGFR	100	0	120	40	0.25	TRUE	NA
ENSG00000181027.11	.	BCM	GRCh38.p13	chr19	46756725	46756725	+	C	C	T	Silent	SNP	ENST00000318584.10	exon4	c.C1275T	p.G425G	exonic	ENSG00000181027.11	.	synonymous SNV	ENSG00000181027.11:ENST00000318584.10:exon4:c.C1275T:p.G425G	19q13.32	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FKRP	592	0	459	583	0.559500959692898	TRUE	NA
ENSG00000063245.15	.	BCM	GRCh38.p13	chr19	55691777	55691777	+	C	C	T	Silent	SNP	ENST00000270460.11	exon7	c.C786T	p.D262D	exonic	ENSG00000063245.15	.	synonymous SNV	ENSG00000063245.15:ENST00000270460.11:exon7:c.C786T:p.D262D	19q13.42	C3N-04282	9.304e-05	0	0.0004	0	0	9.211e-05	0	0	rs373830625	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	EPN1	110	0	113	88	0.437810945273632	TRUE	NA
ENSG00000118473.22	.	BCM	GRCh38.p13	chr1	66694467	66694467	+	A	A	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000118473.22	.	.	.	1p31.3	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SGIP1	94	0	145	34	0.189944134078212	TRUE	TRUE
ENSG00000095951.17	.	BCM	GRCh38.p13	chr6	12020394	12020394	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000095951.17	.	.	.	6p24.1	C3N-04282	.	.	.	.	.	.	.	.	.	1.11	D	.	.	.	.	N	.	.	N	.	T	T	.	0.178	0.381	0.043	.	.	.	T	T	T	T	0.100	2.091	0.593	N	N	-0.720	0.779	-0.961	0.539	1.000	0.676	0.573	0.564	0.714	.	2.710	-2.580	0.009	-1.125	-0.104	0.000	0.000	0.003	780	.	.	.	.	HIVEP1	226	0	208	123	0.371601208459215	TRUE	TRUE
ENSG00000199069.3	.	BCM	GRCh38.p13	chr14	101025781	101025781	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000199069.3	.	.	.	14q32.31	C3N-04282	1.654e-05	0	0	0	0	3.017e-05	0	0	rs762957686	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MIR323A	193	1	267	117	0.3046875	TRUE	NA
ENSG00000229807.12	.	BCM	GRCh38.p13	chrX	73822783	73822783	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000229807.12;ENSG00000270641.1	.	.	.	Xq13.2	C3N-04282	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	XIST	48	0	44	54	0.551020408163265	TRUE	NA
ENSG00000162643.13	.	BCM	GRCh38.p13	chr1	85097586	85097586	+	C	C	G	Missense_Mutation	SNP	ENST00000294664.11	exon12	c.C1281G	p.I427M	exonic	ENSG00000162643.13	.	nonsynonymous SNV	ENSG00000162643.13:ENST00000294664.11:exon12:c.C1281G:p.I427M	1p22.3	C3L-04072	.	.	.	.	.	.	.	.	.	9.20	D	D	D	D	D	N	M	T	D	0.854	T	T	D	0.284	0.377	0.545	0.753	T	T	T	T	D	T	2.422	22.200	0.987	N	N	-0.079	2.242	-0.307	1.550	0.001	0.549	0.588	0.547	0.616	.	5.270	-3.890	0.117	-0.016	0.599	0.991	0.693	0.156	763	.	.	.	.	WDR63	121	0	180	10	0.0526315789473684	TRUE	NA
ENSG00000178104.19	.	BCM	GRCh38.p13	chr1	148981303	148981303	+	G	G	-	Frame_Shift_Del	NA	ENST00000369354.7	exon21	c.2721delG	p.E908Kfs*10	exonic	ENSG00000178104.19	.	frameshift deletion	ENSG00000178104.19:ENST00000369354.7:exon21:c.2721delG:p.E908Kfs*10	1q21.2	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PDE4DIP	279	0	326	105	0.243619489559165	NA	TRUE
ENSG00000135750.15	.	BCM	GRCh38.p13	chr1	233614296	233614296	+	C	C	T	Missense_Mutation	SNP	ENST00000366621.8	exon1	c.C125T	p.S42F	exonic	ENSG00000135750.15	.	nonsynonymous SNV	ENSG00000135750.15:ENST00000366621.8:exon1:c.C125T:p.S42F	1q42.2	C3L-04072	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.872	T	T	D	0.416	0.525	0.583	1.226	D	T	D	D	D	D	4.291	29.500	0.998	D	D	0.656	6.548	0.540	5.545	1.000	0.442	0.522	0.522	0.555	.	4.020	4.020	7.344	0.941	0.535	1.000	0.967	0.963	945	.	.	.	.	KCNK1	463	0	864	51	0.0557377049180328	TRUE	TRUE
ENSG00000162992.3	.	BCM	GRCh38.p13	chr2	181678284	181678284	+	G	G	A	Missense_Mutation	SNP	ENST00000295108.3	exon2	c.C577T	p.R193W	exonic	ENSG00000162992.3	.	nonsynonymous SNV	ENSG00000162992.3:ENST00000295108.3:exon2:c.C577T:p.R193W	2q31.3	C3L-04072	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.748	D	D	D	0.617	0.417	0.979	1.366	D	D	D	D	D	D	4.304	29.600	0.999	N	D	0.819	9.167	0.796	10.016	1.000	0.447	0.563	0.616	0.527	.	6.020	6.020	2.665	1.176	0.676	1.000	1.000	1.000	854	Neurogenic_differentiation_factor,_domain_of_unknown_function	.	.	ID=COSV54551146;OCCURENCE=1(urinary_tract)	NEUROD1	128	0	226	13	0.0543933054393305	TRUE	TRUE
ENSG00000153827.13	.	BCM	GRCh38.p13	chr2	229799354	229799354	+	C	C	T	Missense_Mutation	SNP	ENST00000283943.9	exon21	c.G3011A	p.R1004Q	exonic	ENSG00000153827.13	.	nonsynonymous SNV	ENSG00000153827.13:ENST00000283943.9:exon21:c.G3011A:p.R1004Q	2q36.3	C3L-04072	.	.	.	.	.	.	.	.	.	10.19	D	T	D	D	D	D	N	T	N	0.720	T	T	D	0.238	0.157	0.481	1.163	T	T	D	T	D	D	4.309	29.700	1.000	D	.	0.707	7.219	0.738	8.535	1.000	0.707	0.725	0.725	0.714	.	5.520	5.520	7.448	1.026	0.549	1.000	1.000	0.998	907	.	.	.	.	TRIP12	320	0	458	72	0.135849056603774	TRUE	NA
ENSG00000154310.17	.	BCM	GRCh38.p13	chr3	171126028	171126028	+	C	C	T	Missense_Mutation	SNP	ENST00000436636.7	exon17	c.G1897A	p.V633M	exonic	ENSG00000154310.17	.	nonsynonymous SNV	ENSG00000154310.17:ENST00000436636.7:exon17:c.G1897A:p.V633M	3q26.2	C3L-04072	1.66e-05	0	0	0	0	3.003e-05	0	0	rs780229852	4.20	T	T	D	P	N	N	N	T	N	0.194	T	T	D	0.149	0.068	0.261	0.664	T	T	T	T	T	D	2.153	20.500	0.995	D	N	-0.108	2.148	-0.056	2.176	1.000	0.737	0.725	0.733	0.714	.	5.660	4.790	1.605	1.026	0.599	0.971	0.858	0.935	940	.	.	.	.	TNIK	156	0	239	82	0.255451713395639	TRUE	NA
ENSG00000163961.4	.	BCM	GRCh38.p13	chr3	196487504	196487504	+	-	NA	GCTA	Frame_Shift_Ins	INS	ENST00000318037.3	exon3	c.452_453insTAGC	p.E152Sfs*25	exonic	ENSG00000163961.4	.	frameshift insertion	ENSG00000163961.4:ENST00000318037.3:exon3:c.452_453insTAGC:p.E152Sfs*25	3q29	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF168	NA	NA	NA	NA	NA	NA	NA
ENSG00000198189.11	.	BCM	GRCh38.p13	chr4	87390979	87390979	+	C	C	G	Missense_Mutation	SNP	ENST00000358290.9	exon1	c.G92C	p.R31T	exonic	ENSG00000198189.11	.	nonsynonymous SNV	ENSG00000198189.11:ENST00000358290.9:exon1:c.G92C:p.R31T	4q22.1	C3L-04072	.	.	.	.	.	.	.	.	.	11.16	D	D	.	.	N	D	.	D	D	0.498	T	D	D	0.321	0.501	0.851	0.993	T	.	T	T	D	D	3.231	23.900	0.980	D	D	0.230	3.441	0.202	3.193	1.000	0.442	0.522	0.522	0.562	.	5.980	2.790	0.288	-0.238	0.599	0.361	0.997	0.995	600	.	.	.	.	HSD17B11	283	0	426	36	0.0779220779220779	TRUE	TRUE
ENSG00000213949.10	.	BCM	GRCh38.p13	chr5	52849472	52849472	+	G	G	A	Missense_Mutation	SNP	ENST00000282588.7	exon2	c.G169A	p.E57K	exonic	ENSG00000213949.10	.	nonsynonymous SNV	ENSG00000213949.10:ENST00000282588.7:exon2:c.G169A:p.E57K	5q11.2	C3L-04072	8.298e-06	0	0	0	0	0	0	6.095e-05	rs567216405	6.20	T	T	P	P	D	D	M	T	N	0.484	T	T	T	0.220	0.523	0.789	0.197	T	T	T	T	D	D	3.502	24.700	0.999	D	N	0.461	4.744	0.552	5.668	1.000	0.615	0.588	0.659	0.575	.	5.820	5.820	5.615	1.176	0.671	1.000	0.998	0.995	823	.	.	.	.	ITGA1	72	0	114	39	0.254901960784314	TRUE	NA
ENSG00000113161.16	.	BCM	GRCh38.p13	chr5	75360109	75360109	+	A	A	G	Missense_Mutation	SNP	ENST00000287936.9	exon19	c.A2582G	p.H861R	exonic	ENSG00000113161.16	.	nonsynonymous SNV	ENSG00000113161.16:ENST00000287936.9:exon19:c.A2582G:p.H861R	5q13.3	C3L-04072	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.787	D	D	D	0.521	0.690	0.761	1.203	T	D	D	D	D	D	3.286	24.100	0.998	D	D	0.668	6.698	0.693	7.618	1.000	0.707	0.702	0.702	0.714	.	5.700	5.700	9.272	1.312	0.756	1.000	0.999	0.976	900	Hydroxymethylglutaryl-CoA_reductase,_class_I/II,_conserved_site	.	.	.	HMGCR	269	1	382	104	0.213991769547325	TRUE	TRUE
ENSG00000169131.13	.	BCM	GRCh38.p13	chr5	178713447	178713447	+	A	A	T	Missense_Mutation	SNP	ENST00000335815.7	exon5	c.T431A	p.I144K	exonic	ENSG00000169131.13	.	nonsynonymous SNV	ENSG00000169131.13:ENST00000335815.7:exon5:c.T431A:p.I144K	5q35.3	C3L-04072	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.135	T	T	T	0.046	0.480	0.099	0.365	T	T	T	T	T	T	-0.028	1.171	0.367	N	N	-1.327	0.151	-1.316	0.199	0.010	0.651	0.670	0.651	0.636	.	4.430	-0.930	-1.236	0.114	0.751	0.000	0.038	0.278	969	.	.	.	.	ZNF354A	187	0	325	85	0.207317073170732	TRUE	TRUE
ENSG00000170927.15	.	BCM	GRCh38.p13	chr6	51627053	51627053	+	G	G	A	Missense_Mutation	SNP	ENST00000371117.8	exon66	c.C11729T	p.S3910L	exonic	ENSG00000170927.15	.	nonsynonymous SNV	ENSG00000170927.15:ENST00000371117.8:exon66:c.C11729T:p.S3910L	6p12.3	C3L-04072	.	.	.	.	.	.	.	.	.	4.20	D	D	B	B	N	N	L	D	N	0.165	T	T	D	0.145	0.259	0.944	0.056	T	T	T	T	T	T	1.310	14.460	0.986	N	N	-0.526	1.127	-0.480	1.235	0.000	0.487	0.574	0.574	0.564	.	5.000	4.120	2.114	1.176	0.676	0.075	0.068	0.022	673	.	.	.	.	PKHD1	382	0	531	38	0.0667838312829526	TRUE	TRUE
ENSG00000118412.12	.	BCM	GRCh38.p13	chr6	89868743	89868743	+	C	C	T	Missense_Mutation	SNP	ENST00000551025.3	exon8	c.C5453T	p.S1818L	exonic	ENSG00000118412.12	.	nonsynonymous SNV	ENSG00000118412.12:ENST00000551025.3:exon8:c.C5453T:p.S1818L	6q15	C3L-04072	.	.	.	.	.	.	.	.	.	0.7	.	T	.	.	.	.	.	.	.	.	.	.	.	.	.	0.496	.	T	T	T	T	.	T	0.887	10.300	0.645	N	.	.	.	.	.	0.175	0.295	0.157	0.343	0.221	0.101	5.770	3.760	0.368	1.026	0.599	0.000	0.329	0.095	573	.	.	.	.	CASP8AP2	146	0	242	74	0.234177215189873	TRUE	TRUE
ENSG00000118412.12	.	BCM	GRCh38.p13	chr6	89868800	89868800	+	G	G	A	Missense_Mutation	SNP	ENST00000551025.3	exon8	c.G5510A	p.R1837K	exonic	ENSG00000118412.12	.	nonsynonymous SNV	ENSG00000118412.12:ENST00000551025.3:exon8:c.G5510A:p.R1837K	6q15	C3L-04072	.	.	.	.	.	.	.	.	.	0.7	.	T	.	.	.	.	.	.	.	.	.	.	.	.	.	0.637	.	T	T	T	T	.	T	0.863	10.050	0.499	N	.	.	.	.	.	0.009	0.322	0.319	0.343	0.323	0.131	5.770	3.260	0.299	0.281	-0.102	0.993	0.958	0.734	573	.	.	.	.	CASP8AP2	188	0	281	79	0.219444444444444	TRUE	TRUE
ENSG00000006715.16	.	BCM	GRCh38.p13	chr7	38772631	38772631	+	G	G	A	Missense_Mutation	SNP	ENST00000310301.9	exon13	c.C1019T	p.S340F	exonic	ENSG00000006715.16	.	nonsynonymous SNV	ENSG00000006715.16:ENST00000310301.9:exon13:c.C1019T:p.S340F	7p14.1	C3L-04072	.	.	.	.	.	.	.	.	.	8.20	T	T	D	P	D	D	L	T	N	0.791	T	T	T	0.214	0.381	0.610	0.381	T	T	D	T	D	D	3.710	25.400	0.996	D	D	0.399	4.339	0.401	4.367	1.000	0.707	0.725	0.659	0.714	.	6.060	6.060	9.813	1.083	0.676	1.000	0.899	0.888	749	.	.	.	.	VPS41	106	0	215	22	0.0928270042194093	TRUE	TRUE
ENSG00000164659.15	.	BCM	GRCh38.p13	chr7	86913095	86913095	+	G	G	A	Missense_Mutation	SNP	ENST00000450689.7	exon14	c.C1841T	p.S614L	exonic	ENSG00000164659.15	.	nonsynonymous SNV	ENSG00000164659.15:ENST00000450689.7:exon14:c.C1841T:p.S614L	7q21.12	C3L-04072	0.0003	0.0029	8.67e-05	0	0	0.0001	0	0	rs146838031	4.20	T	T	B	B	D	D	N	T	N	0.296	T	T	T	0.044	.	0.273	0.197	T	T	T	T	T	T	1.971	19.040	0.829	D	D	-0.328	1.547	-0.125	1.978	0.954	0.706	0.710	0.710	0.714	.	5.820	4.020	3.262	1.176	0.676	1.000	1.000	0.996	587	.	.	.	.	KIAA1324L	362	0	506	148	0.226299694189602	TRUE	NA
ENSG00000188037.12	.	BCM	GRCh38.p13	chr7	143323327	143323327	+	G	G	A	Missense_Mutation	SNP	ENST00000343257.7	exon6	c.G715A	p.A239T	exonic	ENSG00000188037.12	.	nonsynonymous SNV	ENSG00000188037.12:ENST00000343257.7:exon6:c.G715A:p.A239T	7q34	C3L-04072	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.968	D	D	D	0.919	0.814	0.977	0.712	T	D	D	D	D	D	4.468	32	0.999	D	D	0.880	10.536	0.801	10.142	1.000	0.428	0.547	0.547	0.613	.	4.270	4.270	10.003	1.172	0.672	1.000	0.999	0.997	.	.	.	.	.	CLCN1	233	0	362	92	0.202643171806167	TRUE	TRUE
ENSG00000104765.16	.	BCM	GRCh38.p13	chr8	26383206	26383206	+	C	C	G	Missense_Mutation	SNP	ENST00000380629.7	exon1	c.C76G	p.L26V	exonic	ENSG00000104765.16	.	nonsynonymous SNV	ENSG00000104765.16:ENST00000380629.7:exon1:c.C76G:p.L26V	8p21.2	C3L-04072	.	.	.	.	.	.	.	.	rs950774191	3.19	D	T	P	P	N	N	L	.	N	0.079	T	T	D	0.118	0.294	0.095	0.269	T	T	T	T	D	T	0.975	11.310	0.925	N	N	-0.821	0.625	-1.086	0.390	1.000	0.442	0.522	0.522	0.562	.	5.100	-5.690	-0.468	-0.416	-0.270	0.003	0.166	0.010	749	.	.	.	.	BNIP3L	341	0	418	71	0.14519427402863	TRUE	NA
ENSG00000213930.12	.	BCM	GRCh38.p13	chr9	34647172	34647172	+	C	C	G	Missense_Mutation	SNP	ENST00000378842.8	exon2	c.C166G	p.Q56E	exonic	ENSG00000213930.12;ENSG00000258728.1	.	nonsynonymous SNV	ENSG00000213930.12:ENST00000378842.8:exon2:c.C166G:p.Q56E,ENSG00000258728.1:ENST00000556278.1:exon2:c.C166G:p.Q56E	9p13.3	C3L-04072	.	.	.	.	.	.	.	.	.	16.20	D	D	D	P	U	D	M	D	N	0.562	D	D	D	0.788	0.422	0.993	1.672	T	D	D	D	D	D	3.780	25.700	0.994	D	D	0.924	11.695	0.880	12.926	1.000	0.442	0.522	0.522	0.562	.	5.770	5.770	7.279	1.026	0.599	1.000	0.997	0.996	327	Galactose-1-phosphate_uridyl_transferase,_N-terminal	.	.	.	GALT	412	2	556	48	0.0794701986754967	TRUE	TRUE
ENSG00000213930.12	.	BCM	GRCh38.p13	chr9	34647243	34647243	+	C	C	G	Missense_Mutation	SNP	ENST00000378842.8	exon2	c.C237G	p.I79M	exonic	ENSG00000213930.12;ENSG00000258728.1	.	nonsynonymous SNV	ENSG00000213930.12:ENST00000378842.8:exon2:c.C237G:p.I79M,ENSG00000258728.1:ENST00000556278.1:exon2:c.C237G:p.I79M	9p13.3	C3L-04072	.	.	.	.	.	.	.	.	.	10.19	D	D	B	B	U	N	.	D	N	0.172	D	D	D	0.540	0.375	0.883	0.943	T	D	D	D	T	D	1.576	16.220	0.942	N	N	-0.815	0.633	-1.106	0.369	1.000	0.628	0.522	0.686	0.658	.	5.530	-11.100	-0.903	-0.105	-0.975	0.000	0.969	0.813	327	Galactose-1-phosphate_uridyl_transferase,_N-terminal	.	.	.	GALT	290	0	360	32	0.0816326530612245	TRUE	TRUE
ENSG00000130559.19	.	BCM	GRCh38.p13	chr9	135822260	135822260	+	G	G	C	Missense_Mutation	SNP	ENST00000389532.9	exon11	c.C2401G	p.Q801E	exonic	ENSG00000130559.19	.	nonsynonymous SNV	ENSG00000130559.19:ENST00000389532.9:exon11:c.C2401G:p.Q801E	9q34.3	C3L-04072	1.648e-05	0	8.637e-05	0.0001	0	0	0	0	rs749774202	13.20	D	D	D	D	D	D	L	T	N	0.699	D	D	D	0.290	0.137	0.557	0.619	T	T	T	T	D	D	3.255	24.000	0.995	D	D	0.622	6.156	0.497	5.136	1.000	0.707	0.725	0.725	0.714	.	5.140	5.140	9.459	1.176	0.676	1.000	0.291	0.077	627	.	.	.	ID=COSV56719156;OCCURENCE=1(oesophagus),1(lung)	CAMSAP1	170	0	286	86	0.231182795698925	TRUE	TRUE
ENSG00000172987.13	.	BCM	GRCh38.p13	chr10	99232465	99232465	+	C	C	T	Missense_Mutation	SNP	ENST00000370552.8	exon2	c.G331A	p.A111T	exonic	ENSG00000172987.13	.	nonsynonymous SNV	ENSG00000172987.13:ENST00000370552.8:exon2:c.G331A:p.A111T	10q24.2	C3L-04072	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.812	T	T	D	0.414	0.821	0.030	0.241	T	D	D	D	D	D	3.471	24.600	0.999	D	D	0.572	5.654	0.600	6.220	1.000	0.623	0.563	0.378	0.530	.	5.270	5.270	6.894	1.026	0.599	1.000	1.000	0.984	385	.	.	.	.	HPSE2	329	0	487	150	0.235478806907378	TRUE	TRUE
ENSG00000197142.10	.	BCM	GRCh38.p13	chr10	112408432	112408432	+	C	C	T	Missense_Mutation	SNP	ENST00000393081.5	exon6	c.C443T	p.S148F	exonic	ENSG00000197142.10	.	nonsynonymous SNV	ENSG00000197142.10:ENST00000393081.5:exon6:c.C443T:p.S148F	10q25.2	C3L-04072	.	.	.	.	.	.	.	.	.	9.20	T	T	B	B	D	D	M	T	D	0.810	T	T	D	0.231	0.681	0.788	0.357	T	T	T	T	D	D	2.380	22.000	0.925	D	D	0.321	3.889	0.445	4.690	1.000	0.707	0.725	0.547	0.586	.	5.920	5.920	6.323	1.010	0.589	1.000	0.932	0.917	821	AMP-dependent_synthetase/ligase	.	.	.	ACSL5	74	0	127	24	0.158940397350993	TRUE	TRUE
ENSG00000148773.14	.	BCM	GRCh38.p13	chr10	128108980	128108980	+	A	A	T	Missense_Mutation	SNP	ENST00000368654.8	exon13	c.T2860A	p.W954R	exonic	ENSG00000148773.14	.	nonsynonymous SNV	ENSG00000148773.14:ENST00000368654.8:exon13:c.T2860A:p.W954R	10q26.2	C3L-04072	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.173	T	T	T	0.019	0.267	0.154	0.112	T	T	T	T	T	T	0.669	8.170	0.649	N	N	-1.155	0.261	-1.193	0.288	0.987	0.707	0.702	0.725	0.714	.	3.440	-0.129	0.552	0.150	0.756	0.000	0.003	0.050	963	.	.	.	.	MKI67	463	0	698	200	0.22271714922049	TRUE	TRUE
ENSG00000165490.13	.	BCM	GRCh38.p13	chr11	82934133	82934133	+	A	A	C	Missense_Mutation	SNP	ENST00000533655.6	exon6	c.A2795C	p.K932T	exonic	ENSG00000165490.13	.	nonsynonymous SNV	ENSG00000165490.13:ENST00000533655.6:exon6:c.A2795C:p.K932T	11q14.1	C3L-04072	.	.	.	.	.	.	.	.	.	1.18	D	T	B	B	N	N	.	T	N	0.125	T	T	T	0.065	0.316	0.145	0.037	.	T	T	T	T	T	1.331	14.610	0.825	N	N	-0.617	0.957	-0.487	1.224	0.725	0.651	0.546	0.651	0.655	.	5.830	4.640	0.813	0.162	0.756	0.019	0.021	0.084	514	.	.	.	.	DDIAS	101	0	169	38	0.183574879227053	TRUE	TRUE
ENSG00000002016.18	.	BCM	GRCh38.p13	chr12	930102	930102	+	C	C	T	Missense_Mutation	SNP	ENST00000358495.8	exon4	c.G229A	p.E77K	exonic	ENSG00000002016.18	.	nonsynonymous SNV	ENSG00000002016.18:ENST00000358495.8:exon4:c.G229A:p.E77K	12p13.33	C3L-04072	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.934	T	T	D	0.490	0.832	0.865	0.574	T	T	D	D	D	D	4.164	28.300	0.999	D	D	0.569	5.619	0.522	5.364	0.998	0.563	0.654	0.609	0.636	.	4.890	3.990	7.811	1.026	0.549	1.000	1.000	0.996	484	.	.	.	.	RAD52	138	0	389	77	0.165236051502146	TRUE	TRUE
ENSG00000213809.9	.	BCM	GRCh38.p13	chr12	10378595	10378595	+	G	G	A	Nonsense_Mutation	SNP	ENST00000240618.11	exon6	c.C388T	p.Q130X	exonic	ENSG00000213809.9	.	stopgain	ENSG00000213809.9:ENST00000240618.11:exon6:c.C388T:p.Q130X	12p13.2	C3L-04072	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	A	.	.	.	0.929	.	.	.	.	.	.	.	.	.	D	D	.	.	7.508	38	0.993	N	N	0.520	5.193	0.261	3.496	0.075	0.554	0.588	0.547	0.528	.	5.960	3.110	3.173	1.155	0.618	0.998	0.998	0.995	861	.	.	.	ID=COSV99555187;OCCURENCE=1(skin)	KLRK1	159	0	461	27	0.055327868852459	TRUE	TRUE
ENSG00000121361.5	.	BCM	GRCh38.p13	chr12	21765872	21765872	+	G	G	T	Missense_Mutation	SNP	ENST00000240662.3	exon3	c.C1126A	p.H376N	exonic	ENSG00000121361.5	.	nonsynonymous SNV	ENSG00000121361.5:ENST00000240662.3:exon3:c.C1126A:p.H376N	12p12.1	C3L-04072	.	.	.	.	.	.	.	.	.	14.20	T	T	D	P	D	D	L	D	N	0.652	D	D	D	0.427	0.370	0.923	2.308	D	T	D	D	D	D	3.079	23.600	0.990	D	D	0.498	5.021	0.599	6.212	1.000	0.487	0.574	0.574	0.542	.	5.600	5.600	7.615	1.157	0.654	1.000	0.951	0.994	746	.	.	.	.	KCNJ8	300	0	718	117	0.140119760479042	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	T	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35A	p.G12D	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35A:p.G12D	12p12.1	C3L-04072	1.976e-05	0.0001	0	0	0	1.873e-05	0	0	rs121913529	16.20	D	D	P	B	D	D	M	T	D	0.915	D	D	D	0.875	0.772	0.957	2.257	D	D	D	D	D	T	3.144	23.700	0.998	D	D	0.606	5.981	0.660	7.073	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497369;OCCURENCE=1(salivary_gland),30(breast),3(penis),22(liver),95(peritoneum),3(genital_tract),18(oesophagus),50(cervix),8956(large_intestine),11(central_nervous_system),453(biliary_tract),1(pleura),345(ovary),2(bone),24(NS),265(haematopoietic_and_lymphoid_tissue),130(stomach),12(kidney),30(soft_tissue),41(urinary_tract),3242(pancreas),20(gastrointestinal_tract_(site_indeterminate)),42(skin),25(prostate),1366(lung),40(thyroid),37(upper_aerodigestive_tract),7(testis),3(eye),103(small_intestine),254(endometrium)	KRAS	274	0	427	357	0.455357142857143	TRUE	TRUE
ENSG00000123342.16	.	BCM	GRCh38.p13	chr12	55837632	55837632	+	-	NA	G	Frame_Shift_Ins	INS	ENST00000322569.9	exon8	c.1110dupC	p.K371Qfs*5	exonic	ENSG00000123342.16	.	frameshift insertion	ENSG00000123342.16:ENST00000322569.9:exon8:c.1110dupC:p.K371Qfs*5	12q13.2	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MMP19	NA	NA	NA	NA	NA	NA	NA
ENSG00000133116.8	.	BCM	GRCh38.p13	chr13	33063878	33063878	+	G	G	A	Missense_Mutation	SNP	ENST00000380099.4	exon5	c.G2731A	p.G911R	exonic	ENSG00000133116.8	.	nonsynonymous SNV	ENSG00000133116.8:ENST00000380099.4:exon5:c.G2731A:p.G911R	13q13.1	C3L-04072	8.237e-06	0	0	0	0	1.499e-05	0	0	rs777451765	17.20	D	D	D	D	D	D	H	T	D	0.900	D	D	D	0.835	0.774	0.944	0.630	T	T	D	D	D	D	4.416	31	0.999	D	D	0.914	11.428	0.789	9.816	1.000	0.554	0.588	0.547	0.613	.	5.330	5.330	9.889	1.172	0.676	1.000	0.982	0.448	542	.	.	.	ID=COSV66310398;OCCURENCE=1(large_intestine)	KL	270	2	365	88	0.194260485651214	TRUE	TRUE
ENSG00000054654.18	.	BCM	GRCh38.p13	chr14	64152690	64152690	+	C	C	T	Nonsense_Mutation	SNP	ENST00000344113.8	exon85	c.C15766T	p.Q5256X	exonic	ENSG00000054654.18	.	stopgain	ENSG00000054654.18:ENST00000344113.8:exon85:c.C15766T:p.Q5256X	14q23.2	C3L-04072	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	N	A	.	.	.	0.910	.	.	.	.	.	.	.	.	.	D	D	.	.	9.021	47	0.998	D	N	0.623	6.161	0.368	4.137	0.420	0.707	0.725	0.725	0.714	.	5.940	5.040	1.876	1.026	0.599	0.962	0.980	0.652	544	.	.	.	.	SYNE2	216	0	357	31	0.0798969072164948	TRUE	TRUE
ENSG00000103932.12	.	BCM	GRCh38.p13	chr15	41527053	41527053	+	G	G	A	Missense_Mutation	SNP	ENST00000304330.9	exon14	c.C1762T	p.R588W	exonic	ENSG00000103932.12	.	nonsynonymous SNV	ENSG00000103932.12:ENST00000304330.9:exon14:c.C1762T:p.R588W	15q15.1	C3L-04072	.	.	.	.	.	.	.	.	.	10.20	D	D	P	B	N	D	M	T	D	0.582	T	T	D	0.464	0.502	0.890	0.220	T	T	T	T	D	D	3.413	24.400	0.997	D	D	0.121	2.968	0.133	2.876	0.054	0.707	0.725	0.725	0.714	.	5.100	1.900	4.527	1.164	0.662	1.000	0.990	0.910	199	.	.	.	ID=COSV58538487;OCCURENCE=1(cervix)	RPAP1	95	0	151	37	0.196808510638298	TRUE	TRUE
ENSG00000104177.18	.	BCM	GRCh38.p13	chr15	48178197	48178197	+	C	C	G	Missense_Mutation	SNP	ENST00000324324.12	exon1	c.G41C	p.G14A	exonic	ENSG00000104177.18	.	nonsynonymous SNV	ENSG00000104177.18:ENST00000324324.12:exon1:c.G41C:p.G14A	15q21.1	C3L-04072	.	.	.	.	.	.	.	.	.	5.17	D	D	.	.	N	D	.	T	N	0.195	T	T	D	0.146	0.110	0.349	0.431	T	T	T	T	D	T	2.043	19.580	0.988	N	N	0.204	3.320	0.121	2.820	1.000	0.442	0.484	0.522	0.373	.	4.170	4.170	1.768	0.933	0.576	0.005	0.216	0.587	798	.	.	.	.	MYEF2	290	0	357	94	0.208425720620843	TRUE	TRUE
ENSG00000073417.15	.	BCM	GRCh38.p13	chr15	85113930	85113930	+	C	C	G	Missense_Mutation	SNP	ENST00000394553.6	exon14	c.C1243G	p.L415V	exonic	ENSG00000073417.15	.	nonsynonymous SNV	ENSG00000073417.15:ENST00000394553.6:exon14:c.C1243G:p.L415V	15q25.3	C3L-04072	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	N	0.725	T	T	D	0.435	0.416	0.416	0.743	T	T	T	T	D	D	2.686	22.800	0.994	D	D	0.109	2.920	-0.006	2.339	0.982	0.707	0.725	0.659	0.714	.	5.230	0.407	2.413	-0.262	-0.773	1.000	0.992	0.958	572	.	.	.	.	PDE8A	179	0	272	68	0.2	TRUE	NA
ENSG00000178952.11	.	BCM	GRCh38.p13	chr16	28845966	28845966	+	T	T	C	Missense_Mutation	SNP	ENST00000313511.8	exon2	c.A193G	p.T65A	exonic	ENSG00000178952.11	.	nonsynonymous SNV	ENSG00000178952.11:ENST00000313511.8:exon2:c.A193G:p.T65A	16p11.2	C3L-04072	.	.	.	.	.	.	.	.	.	14.16	D	D	.	.	D	D	.	T	D	0.908	D	D	D	0.777	.	0.867	1.603	T	.	D	D	D	D	4.349	30	0.998	D	D	0.986	13.503	0.909	14.123	1.000	0.442	0.522	0.522	0.562	.	6.000	6.000	6.702	1.138	0.665	1.000	0.998	0.995	285	.	.	.	.	TUFM	608	0	819	226	0.216267942583732	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674859	7674859	+	C	C	G	Missense_Mutation	SNP	ENST00000269305.8	exon6	c.G672C	p.E224D	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon6:c.G672C:p.E224D	17p13.1	C3L-04072	.	.	.	.	.	.	.	.	.	15.20	D	D	B	B	D	D	M	D	N	0.501	D	D	D	0.697	0.546	0.946	0.651	T	D	D	D	D	T	5.210	33	0.995	D	D	0.062	2.739	0.195	3.158	0.999	0.732	0.698	0.744	0.735	.	5.280	4.310	6.162	1.026	0.599	1.000	0.998	0.992	433	p53,_DNA-binding_domain	.	.	ID=COSV52721244;OCCURENCE=4(breast),2(large_intestine),1(central_nervous_system),1(bone),1(haematopoietic_and_lymphoid_tissue),1(stomach),1(urinary_tract),5(lung)	TP53	313	0	351	129	0.26875	TRUE	TRUE
ENSG00000108375.12	.	BCM	GRCh38.p13	chr17	58415447	58415447	+	-	NA	G	Frame_Shift_Ins	INS	ENST00000584437.5	exon1	c.130dupC	p.Q44Pfs*31	exonic	ENSG00000108375.12;ENSG00000285897.1	.	frameshift insertion	ENSG00000108375.12:ENST00000584437.5:exon1:c.130dupC:p.Q44Pfs*31,ENSG00000285897.1:ENST00000648873.1:exon1:c.130dupC:p.Q44Pfs*31	17q22	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF43	NA	NA	NA	NA	NA	NA	NA
ENSG00000099817.12	.	BCM	GRCh38.p13	chr19	1095291	1095291	+	G	G	C	Missense_Mutation	SNP	ENST00000615234.5	exon1	c.C25G	p.R9G	exonic	ENSG00000099817.12	.	nonsynonymous SNV	ENSG00000099817.12:ENST00000615234.5:exon1:c.C25G:p.R9G	19p13.3	C3L-04072	.	.	.	.	.	.	.	.	.	12.18	.	D	D	D	D	D	M	T	.	0.870	T	T	D	0.635	0.884	0.740	.	D	T	D	D	D	D	4.892	33	0.998	N	N	0.617	6.099	0.540	5.548	1.000	0.726	0.522	0.594	0.562	.	5.150	4.100	3.398	1.078	0.672	1.000	1.000	0.998	988	RNA_polymerase,_Rpb5,_N-terminal	.	.	ID=COSV53124052;OCCURENCE=1(pancreas)	POLR2E	245	1	289	77	0.210382513661202	TRUE	TRUE
ENSG00000088247.17	.	BCM	GRCh38.p13	chr19	6416404	6416404	+	G	G	C	Missense_Mutation	SNP	ENST00000398148.7	exon15	c.C1492G	p.P498A	exonic	ENSG00000088247.17	.	nonsynonymous SNV	ENSG00000088247.17:ENST00000398148.7:exon15:c.C1492G:p.P498A	19p13.3	C3L-04072	.	.	.	.	.	.	.	.	.	11.20	T	D	D	D	D	D	M	T	D	0.612	T	T	D	0.328	0.301	0.519	2.031	T	T	T	T	D	T	3.250	24.000	0.918	D	D	0.776	8.322	0.783	9.639	1.000	0.707	0.698	0.702	0.714	.	5.410	5.410	7.059	1.176	0.676	1.000	0.998	0.990	795	.	.	.	.	KHSRP	339	0	367	70	0.160183066361556	TRUE	TRUE
ENSG00000172519.9	.	BCM	GRCh38.p13	chr19	15794547	15794547	+	G	G	A	Missense_Mutation	SNP	ENST00000642092.1	exon2	c.G499A	p.A167T	exonic	ENSG00000172519.9	.	nonsynonymous SNV	ENSG00000172519.9:ENST00000642092.1:exon2:c.G499A:p.A167T	19p13.12	C3L-04072	0.0005	0	0.0002	0.0001	0	0.0003	0.0011	0.0024	rs201858159	0.20	T	T	B	B	N	N	N	T	N	0.038	T	T	T	0.010	.	0.040	0.273	T	T	T	T	T	T	0.047	1.656	0.708	N	N	-1.805	0.023	-1.770	0.038	0.000	0.487	0.574	0.574	0.564	.	3.360	-0.366	-1.428	-0.933	-0.742	0.000	0.000	0.000	976	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV58277840;OCCURENCE=1(large_intestine)	OR10H5	314	0	429	96	0.182857142857143	NA	TRUE
ENSG00000088876.13	.	BCM	GRCh38.p13	chr20	2483750	2483750	+	G	G	C	Nonsense_Mutation	SNP	ENST00000278772.9	exon6	c.C1211G	p.S404X	exonic	ENSG00000088876.13	.	stopgain	ENSG00000088876.13:ENST00000278772.9:exon6:c.C1211G:p.S404X	20p13	C3L-04072	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	.	D	.	.	.	0.072	.	.	.	.	.	.	.	.	.	D	D	.	.	5.396	34	0.992	D	N	0.458	4.729	0.124	2.837	0.001	0.615	0.654	0.659	0.636	.	2.830	0.629	3.185	-0.016	-0.191	0.605	0.006	0.035	900	Zinc_finger_C2H2-type	.	.	.	ZNF343	252	1	200	101	0.335548172757475	TRUE	TRUE
ENSG00000125817.8	.	BCM	GRCh38.p13	chr20	3786402	3786402	+	T	T	A	Nonsense_Mutation	SNP	ENST00000379751.5	exon1	c.A82T	p.K28X	exonic	ENSG00000125817.8	.	stopgain	ENSG00000125817.8:ENST00000379751.5:exon1:c.A82T:p.K28X	20p13	C3L-04072	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	U	D	.	.	.	0.688	.	.	.	.	.	.	.	.	.	D	D	.	.	6.916	36	0.994	D	N	0.494	4.986	0.287	3.639	1.000	0.726	0.522	0.594	0.273	.	2.900	2.900	0.785	0.931	0.438	0.871	1.000	0.996	809	DNA_binding_HTH_domain,_Psq-type	.	.	.	CENPB	288	0	291	143	0.329493087557604	TRUE	TRUE
ENSG00000173198.6	.	BCM	GRCh38.p13	chrX	78272750	78272750	+	C	C	A	Nonsense_Mutation	SNP	ENST00000373304.4	exon3	c.G997T	p.E333X	exonic	ENSG00000173198.6	.	stopgain	ENSG00000173198.6:ENST00000373304.4:exon3:c.G997T:p.E333X	Xq21.1	C3L-04072	.	.	.	.	.	.	.	.	.	2.5	.	.	.	.	N	N	.	.	.	0.552	.	.	.	.	.	.	.	.	.	D	D	.	.	6.187	35	0.993	N	.	.	.	.	.	0.045	.	.	.	.	.	4.300	4.300	1.649	1.026	0.549	0.254	0.972	0.767	388	.	.	.	.	CYSLTR1	23	0	31	10	0.24390243902439	TRUE	TRUE
ENSG00000136040.9	.	BCM	GRCh38.p13	chr12	94297221	94297221	+	G	G	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000136040.9	ENST00000258526.9:exon25:c.3966+1G>T	.	.	12q22	C3L-04072	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.876	35	0.994	D	.	0.994	13.721	0.814	10.562	1.000	0.156	0.156	0.084	0.093	0.978	4.730	3.810	4.891	1.176	0.676	1.000	1.000	0.894	969	.	.	.	.	PLXNC1	226	0	286	100	0.259067357512953	TRUE	TRUE
ENSG00000185278.15	.	BCM	GRCh38.p13	chr1	173870276	173870276	+	T	T	A	Silent	SNP	ENST00000367701.9	exon2	c.T51A	p.S17S	exonic	ENSG00000185278.15	.	synonymous SNV	ENSG00000185278.15:ENST00000367701.9:exon2:c.T51A:p.S17S	1q25.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZBTB37	134	0	180	64	0.262295081967213	TRUE	TRUE
ENSG00000115705.22	.	BCM	GRCh38.p13	chr2	1484763	1484763	+	G	G	A	Silent	SNP	ENST00000329066.9	exon9	c.G1506A	p.R502R	exonic	ENSG00000115705.22	.	synonymous SNV	ENSG00000115705.22:ENST00000329066.9:exon9:c.G1506A:p.R502R	2p25.3	C3L-04072	5.793e-05	0	8.661e-05	0	0	9.05e-05	0	0	rs773237793	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TPO	301	0	412	127	0.235621521335807	TRUE	NA
ENSG00000163961.4	.	BCM	GRCh38.p13	chr3	196487507	196487507	+	C	C	T	Silent	SNP	ENST00000318037.3	exon3	c.G450A	p.L150L	exonic	ENSG00000163961.4	.	synonymous SNV	ENSG00000163961.4:ENST00000318037.3:exon3:c.G450A:p.L150L	3q29	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RNF168	414	0	711	133	0.157582938388626	TRUE	NA
ENSG00000147570.10	.	BCM	GRCh38.p13	chr8	66076813	66076813	+	C	C	T	Silent	SNP	ENST00000276570.10	exon4	c.C273T	p.A91A	exonic	ENSG00000147570.10	.	synonymous SNV	ENSG00000147570.10:ENST00000276570.10:exon4:c.C273T:p.A91A	8q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAJC5B	395	1	491	81	0.141608391608392	TRUE	TRUE
ENSG00000148680.16	.	BCM	GRCh38.p13	chr10	90857288	90857288	+	G	G	C	Silent	SNP	ENST00000336152.8	exon1	c.C384G	p.L128L	exonic	ENSG00000148680.16	.	synonymous SNV	ENSG00000148680.16:ENST00000336152.8:exon1:c.C384G:p.L128L	10q23.31	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HTR7	248	0	460	35	0.0707070707070707	TRUE	TRUE
ENSG00000183269.5	.	BCM	GRCh38.p13	chr11	5857235	5857235	+	C	C	G	Silent	SNP	ENST00000537935.1	exon1	c.G468C	p.L156L	exonic	ENSG00000183269.5	.	synonymous SNV	ENSG00000183269.5:ENST00000537935.1:exon1:c.G468C:p.L156L	11p15.4	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR52E8	89	0	114	70	0.380434782608696	TRUE	TRUE
ENSG00000132275.11	.	BCM	GRCh38.p13	chr11	6600245	6600245	+	G	G	A	Silent	SNP	ENST00000254605.11	exon7	c.C1272T	p.F424F	exonic	ENSG00000132275.11	.	synonymous SNV	ENSG00000132275.11:ENST00000254605.11:exon7:c.C1272T:p.F424F	11p15.4	C3L-04072	8.531e-06	9.764e-05	0	0	0	0	0	0	rs144962503	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RRP8	48	0	48	12	0.2	TRUE	NA
ENSG00000184271.17	.	BCM	GRCh38.p13	chr12	51190589	51190589	+	G	G	A	Silent	SNP	ENST00000333640.11	exon11	c.C1494T	p.F498F	exonic	ENSG00000184271.17	.	synonymous SNV	ENSG00000184271.17:ENST00000333640.11:exon11:c.C1494T:p.F498F	12q13.13	C3L-04072	1.673e-05	0	0	0	0	0	0	0.0001	rs750339632	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV104659560;OCCURENCE=1(skin)	POU6F1	106	0	203	12	0.0558139534883721	TRUE	NA
ENSG00000185567.7	.	BCM	GRCh38.p13	chr14	104950183	104950183	+	G	G	C	Silent	SNP	ENST00000333244.6	exon7	c.C5268G	p.L1756L	exonic	ENSG00000185567.7	.	synonymous SNV	ENSG00000185567.7:ENST00000333244.6:exon7:c.C5268G:p.L1756L	14q32.33	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AHNAK2	580	0	896	67	0.0695742471443406	NA	TRUE
ENSG00000259288.7	.	BCM	GRCh38.p13	chr15	40240681	40240681	+	G	G	A	Unknown	SNP	NA	NA	NA	NA	exonic	ENSG00000259288.7	.	unknown	UNKNOWN	15q15.1	C3L-04072	.	.	.	.	.	.	.	.	rs566666956	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BUB1B-PAK6	122	0	204	51	0.2	TRUE	NA
ENSG00000167984.18	.	BCM	GRCh38.p13	chr16	3564598	3564598	+	G	G	A	Silent	SNP	ENST00000359128.10	exon5	c.C339T	p.R113R	exonic	ENSG00000167984.18	.	synonymous SNV	ENSG00000167984.18:ENST00000359128.10:exon5:c.C339T:p.R113R	16p13.3	C3L-04072	2.69e-05	0.0001	0	0.0001	0	1.651e-05	0	0	rs373142707	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100072814;OCCURENCE=1(soft_tissue)	NLRC3	222	0	247	98	0.284057971014493	TRUE	NA
ENSG00000198900.6	.	BCM	GRCh38.p13	chr20	41115436	41115436	+	C	C	T	Silent	SNP	ENST00000361337.3	exon16	c.C1704T	p.L568L	exonic	ENSG00000198900.6	.	synonymous SNV	ENSG00000198900.6:ENST00000361337.3:exon16:c.C1704T:p.L568L	20q12	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TOP1	103	0	218	13	0.0562770562770563	TRUE	TRUE
ENSG00000156253.7	.	BCM	GRCh38.p13	chr21	29007988	29007988	+	G	G	A	Silent	SNP	ENST00000493196.2	exon4	c.C498T	p.V166V	exonic	ENSG00000156253.7	.	synonymous SNV	ENSG00000156253.7:ENST00000493196.2:exon4:c.C498T:p.V166V	21q21.3	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RWDD2B	252	0	355	23	0.0608465608465608	TRUE	TRUE
ENSG00000115956.10	.	BCM	GRCh38.p13	chr2	68395818	68395818	+	G	G	A	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000115956.10	ENST00000234313.8:c.*2G>A	.	.	2p14	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PLEK	181	0	264	23	0.0801393728222996	TRUE	NA
ENSG00000270117.1	.	BCM	GRCh38.p13	chr11	65498368	65498368	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000270117.1	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AP000769.2	107	0	178	36	0.168224299065421	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65499079	65499079	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	rs773811321	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	151	0	211	44	0.172549019607843	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65499309	65499309	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	180	0	300	62	0.171270718232044	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65499509	65499509	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	108	0	217	46	0.174904942965779	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65499606	65499606	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	122	0	212	42	0.165354330708661	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65499691	65499691	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	rs187715624	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	73	0	157	33	0.173684210526316	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65499943	65499943	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	rs899566078	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	89	0	149	27	0.153409090909091	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65500073	65500073	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	141	0	237	41	0.147482014388489	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65500950	65500950	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	153	0	246	52	0.174496644295302	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65501795	65501795	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	128	0	237	44	0.156583629893238	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65502603	65502603	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	42	1	65	14	0.177215189873418	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65502918	65502918	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8;ENSG00000278217.1	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	103	0	175	41	0.189814814814815	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65503064	65503064	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	0.0001	0	0.0002	0.0010	0	2.785e-05	0	0	rs755452277	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	80	0	127	25	0.164473684210526	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65503781	65503781	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	59	0	98	11	0.100917431192661	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65503784	65503784	+	C	C	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	59	0	98	11	0.100917431192661	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65503835	65503835	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	68	0	106	25	0.190839694656489	TRUE	NA
ENSG00000251562.8	.	BCM	GRCh38.p13	chr11	65505304	65505304	+	G	G	A	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000251562.8	.	.	.	11q13.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MALAT1	143	0	234	50	0.176056338028169	TRUE	NA
ENSG00000238244.3	.	BCM	GRCh38.p13	chr15	90349149	90349149	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000238244.3;ENSG00000279980.1	.	.	.	15q26.1	C3L-04072	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GABARAPL3	250	0	400	100	0.2	TRUE	NA
ENSG00000205786.8	.	BCM	GRCh38.p13	chr19	35408287	35408287	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000205786.8	.	.	.	19q13.12	C3L-04072	0.0004	0	0	0	0	0	0	0.0007	rs145775447	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC01531	44	1	82	27	0.247706422018349	TRUE	NA
ENSG00000142733.17	.	BCM	GRCh38.p13	chr1	27366492	27366510	+	CCGGGGGCGCCGCGAGCTG	CCGGGGGCGCCGCGAGCTG	-	Frame_Shift_Del	DEL	ENST00000357582.3	exon1	c.88_106del	p.Q30Afs*16	exonic	ENSG00000142733.17	.	frameshift deletion	ENSG00000142733.17:ENST00000357582.3:exon1:c.88_106del:p.Q30Afs*16	1p36.11	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP3K6	18	0	13	13	0.5	TRUE	TRUE
ENSG00000116544.12	.	BCM	GRCh38.p13	chr1	34905013	34905013	+	T	T	A	Missense_Mutation	SNP	ENST00000373347.6	exon3	c.A371T	p.Q124L	exonic	ENSG00000116544.12	.	nonsynonymous SNV	ENSG00000116544.12:ENST00000373347.6:exon3:c.A371T:p.Q124L	1p34.3	C3L-02613	.	.	.	.	.	.	.	.	.	14.20	D	D	P	P	D	D	M	T	D	0.826	T	T	D	0.357	0.183	0.571	1.450	T	D	D	D	D	D	3.806	25.900	0.995	D	D	0.551	5.457	0.541	5.556	1.000	0.653	0.610	0.597	0.613	.	4.470	4.470	7.899	1.129	0.654	1.000	1.000	1.000	914	.	.	.	ID=COSV99332805;OCCURENCE=1(stomach)	DLGAP3	323	0	626	297	0.321776814734561	TRUE	TRUE
ENSG00000163873.10	.	BCM	GRCh38.p13	chr1	36825724	36825724	+	G	G	A	Nonsense_Mutation	SNP	ENST00000373091.8	exon11	c.C1633T	p.R545X	exonic	ENSG00000163873.10	.	stopgain	ENSG00000163873.10:ENST00000373091.8:exon11:c.C1633T:p.R545X	1p34.3	C3L-02613	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	A	.	.	.	0.976	.	.	.	.	.	.	.	.	.	D	D	.	.	7.741	39	0.998	D	N	0.867	10.240	0.753	8.872	1.000	0.615	0.590	0.659	0.564	.	5.460	5.460	4.784	1.176	0.676	1.000	0.994	0.995	582	Ionotropic_glutamate_receptor,_L-glutamate_and_glycine-binding_domain;Ionotropic_glutamate_receptor	.	.	.	GRIK3	125	0	246	105	0.299145299145299	TRUE	TRUE
ENSG00000127603.29	.	BCM	GRCh38.p13	chr1	39387757	39387757	+	C	C	A	Missense_Mutation	SNP	ENST00000372915.7	exon57	c.C14930A	p.S4977Y	exonic	ENSG00000127603.29	.	nonsynonymous SNV	ENSG00000127603.29:ENST00000372915.7:exon57:c.C14930A:p.S4977Y	1p34.3	C3L-02613	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	D	D	.	T	D	0.384	T	T	T	0.153	0.438	0.227	.	T	T	T	T	D	D	3.525	24.800	0.986	D	D	0.515	5.151	0.541	5.556	1.000	0.731	0.725	0.723	0.649	.	6.170	5.270	4.556	1.026	0.599	1.000	1.000	0.998	809	.	.	.	.	MACF1	216	0	467	163	0.258730158730159	TRUE	TRUE
ENSG00000178965.14	.	BCM	GRCh38.p13	chr1	74573120	74573120	+	C	C	T	Missense_Mutation	SNP	ENST00000326665.10	exon14	c.G2590A	p.A864T	exonic	ENSG00000178965.14	.	nonsynonymous SNV	ENSG00000178965.14:ENST00000326665.10:exon14:c.G2590A:p.A864T	1p31.1	C3L-02613	.	.	.	.	.	.	.	.	.	1.18	T	T	D	P	.	N	N	T	N	0.112	T	T	T	0.081	0.250	0.110	0.021	.	T	T	T	T	T	1.695	16.990	0.873	N	N	-0.360	1.471	-0.444	1.296	0.000	0.516	0.610	0.547	0.564	.	5.230	3.250	1.158	0.129	0.599	0.001	0.001	0.005	713	.	.	.	.	ERICH3	97	0	173	76	0.305220883534137	TRUE	TRUE
ENSG00000134249.7	.	BCM	GRCh38.p13	chr1	119894096	119894096	+	T	T	A	Missense_Mutation	SNP	ENST00000369400.2	exon1	c.A2241T	p.K747N	exonic	ENSG00000134249.7	.	nonsynonymous SNV	ENSG00000134249.7:ENST00000369400.2:exon1:c.A2241T:p.K747N	1p12	C3L-02613	.	.	.	.	.	.	.	.	.	1.19	D	T	B	B	.	N	N	T	N	0.175	T	T	T	0.004	0.226	0.072	0.122	T	T	T	T	T	T	-0.032	1.146	0.864	N	N	-1.277	0.178	-1.379	0.162	1.000	0.497	0.590	0.547	0.542	.	2.360	-2.740	-0.283	0.644	-0.770	0.000	0.007	0.001	882	.	.	.	.	ADAM30	288	0	409	148	0.265709156193896	TRUE	TRUE
ENSG00000134250.20	.	BCM	GRCh38.p13	chr1	119915749	119915749	+	G	G	A	Nonsense_Mutation	SNP	ENST00000256646.7	exon34	c.C6973T	p.Q2325X	exonic	ENSG00000134250.20	.	stopgain	ENSG00000134250.20:ENST00000256646.7:exon34:c.C6973T:p.Q2325X	1p12	C3L-02613	.	.	.	.	.	.	.	.	.	4.6	.	.	.	.	U	D	.	.	.	0.730	.	.	.	.	.	.	.	.	.	D	D	.	.	8.477	43	0.997	D	N	1.115	18.203	0.972	17.212	0.998	0.707	0.660	0.725	0.714	.	5.500	5.500	4.913	1.101	0.590	1.000	0.994	0.989	837	.	.	.	ID=COSV56682148;OCCURENCE=2(haematopoietic_and_lymphoid_tissue)	NOTCH2	46	0	121	52	0.300578034682081	TRUE	TRUE
ENSG00000163346.17	.	BCM	GRCh38.p13	chr1	154951246	154951246	+	G	G	T	Nonsense_Mutation	SNP	ENST00000368463.8	exon5	c.C395A	p.S132X	exonic	ENSG00000163346.17	.	stopgain	ENSG00000163346.17:ENST00000368463.8:exon5:c.C395A:p.S132X	1q21.3	C3L-02613	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	A	.	.	.	0.197	.	.	.	.	.	.	.	.	.	D	D	.	.	5.896	35	0.983	N	N	0.219	3.389	-0.079	2.108	1.000	0.707	0.686	0.644	0.714	.	4.290	3.330	1.751	1.176	0.618	0.031	0.115	0.284	331	.	.	.	.	PBXIP1	109	0	301	168	0.358208955223881	TRUE	TRUE
ENSG00000116833.14	.	BCM	GRCh38.p13	chr1	200120907	200120907	+	G	G	C	Missense_Mutation	SNP	ENST00000367362.8	exon7	c.G1330C	p.D444H	exonic	ENSG00000116833.14	.	nonsynonymous SNV	ENSG00000116833.14:ENST00000367362.8:exon7:c.G1330C:p.D444H	1q32.1	C3L-02613	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.950	D	D	D	0.956	0.905	0.954	1.411	T	D	D	D	D	D	4.366	31	0.996	D	D	1.096	17.336	1.026	20.536	1.000	0.554	0.590	0.602	0.564	.	5.760	5.760	9.953	1.176	0.676	1.000	1.000	0.999	895	Nuclear_hormone_receptor,_ligand-binding_domain	.	.	.	NR5A2	131	0	174	82	0.3203125	TRUE	TRUE
ENSG00000076356.7	.	BCM	GRCh38.p13	chr1	208103164	208103164	+	C	C	A	Missense_Mutation	SNP	ENST00000367033.4	exon5	c.G1590T	p.W530C	exonic	ENSG00000076356.7	.	nonsynonymous SNV	ENSG00000076356.7:ENST00000367033.4:exon5:c.G1590T:p.W530C	1q32.2	C3L-02613	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	H	D	D	0.975	D	D	D	0.928	0.905	0.924	1.067	T	T	D	D	D	D	4.289	29.500	0.995	D	D	0.970	12.999	0.868	12.455	1.000	0.672	0.596	0.576	0.711	.	4.800	4.800	7.624	1.026	0.599	1.000	1.000	0.996	917	PSI_domain	.	.	.	PLXNA2	203	0	436	151	0.257240204429302	TRUE	TRUE
ENSG00000119283.15	.	BCM	GRCh38.p13	chr1	231209087	231209087	+	G	G	A	Missense_Mutation	SNP	ENST00000366653.5	exon8	c.G1960A	p.E654K	exonic	ENSG00000119283.15	.	nonsynonymous SNV	ENSG00000119283.15:ENST00000366653.5:exon8:c.G1960A:p.E654K	1q42.2	C3L-02613	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.983	D	D	D	0.890	0.891	0.877	1.567	T	T	D	D	D	D	4.288	29.500	0.999	D	D	0.964	12.822	0.910	14.168	1.000	0.428	0.547	0.547	0.613	.	5.730	4.760	7.951	1.176	0.676	1.000	1.000	0.996	889	0.000	.	.	.	TRIM67	118	0	301	119	0.283333333333333	TRUE	NA
ENSG00000162714.12	.	BCM	GRCh38.p13	chr1	247328725	247328725	+	C	C	A	Missense_Mutation	SNP	ENST00000294753.8	exon4	c.G532T	p.G178W	exonic	ENSG00000162714.12	.	nonsynonymous SNV	ENSG00000162714.12:ENST00000294753.8:exon4:c.G532T:p.G178W	1q44	C3L-02613	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	D	D	M	T	D	0.513	T	T	T	0.195	0.445	0.219	1.410	T	T	T	T	D	T	3.541	24.800	0.994	D	N	0.382	4.234	0.336	3.935	1.000	0.707	0.702	0.702	0.714	.	4.700	4.700	2.720	0.921	0.599	0.944	0.232	0.437	912	.	.	.	.	ZNF496	45	0	101	53	0.344155844155844	TRUE	TRUE
ENSG00000084674.15	.	BCM	GRCh38.p13	chr2	21007462	21007462	+	G	G	C	Missense_Mutation	SNP	ENST00000233242.5	exon26	c.C9406G	p.R3136G	exonic	ENSG00000084674.15	.	nonsynonymous SNV	ENSG00000084674.15:ENST00000233242.5:exon26:c.C9406G:p.R3136G	2p24.1	C3L-02613	.	.	.	.	.	.	.	.	.	2.15	T	T	.	.	N	N	.	T	N	0.073	T	T	T	0.004	0.427	0.364	0.044	T	.	T	T	D	.	0.817	9.562	0.691	N	D	-1.190	0.234	-1.148	0.329	0.995	0.487	0.590	0.574	0.564	.	5.680	0.363	0.174	0.200	-0.140	0.000	0.261	0.316	861	.	.	.	.	APOB	262	0	396	169	0.299115044247788	TRUE	TRUE
ENSG00000152291.14	.	BCM	GRCh38.p13	chr2	85327445	85327445	+	T	T	C	Missense_Mutation	SNP	ENST00000377386.8	exon2	c.A287G	p.N96S	exonic	ENSG00000152291.14	.	nonsynonymous SNV	ENSG00000152291.14:ENST00000377386.8:exon2:c.A287G:p.N96S	2p11.2	C3L-02613	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.101	T	T	T	0.014	.	0.081	.	T	T	T	T	T	T	-1.258	0.002	0.499	N	N	-1.962	0.011	-2.050	0.011	1.000	0.442	0.522	0.522	0.562	.	3.220	-6.440	-1.959	-5.337	-4.031	0.000	0.000	0.000	894	.	.	.	.	TGOLN2	454	1	816	409	0.333877551020408	TRUE	NA
ENSG00000187627.16	.	BCM	GRCh38.p13	chr2	86986832	86986832	+	T	T	A	Missense_Mutation	SNP	ENST00000409776.6	exon20	c.T3909A	p.D1303E	exonic	ENSG00000187627.16	.	nonsynonymous SNV	ENSG00000187627.16:ENST00000409776.6:exon20:c.T3909A:p.D1303E	2p11.2	C3L-02613	.	.	.	.	.	.	.	.	.	9.19	D	T	D	D	.	N	M	T	D	0.248	T	T	T	0.085	0.154	0.076	.	T	T	T	T	D	D	3.064	23.500	0.994	D	D	-0.055	2.323	-0.143	1.928	0.000	0.638	0.670	0.653	0.668	.	2.350	1.140	1.763	1.014	0.319	1.000	1.000	0.991	544	.	.	.	.	RGPD1	59	0	139	47	0.252688172043011	NA	TRUE
ENSG00000144026.12	.	BCM	GRCh38.p13	chr2	95150049	95150049	+	T	T	C	Missense_Mutation	SNP	ENST00000295208.7	exon5	c.A436G	p.T146A	exonic	ENSG00000144026.12	.	nonsynonymous SNV	ENSG00000144026.12:ENST00000295208.7:exon5:c.A436G:p.T146A	2q11.1	C3L-02613	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	.	N	N	T	N	0.140	T	T	T	0.076	0.405	0.328	0.044	T	T	T	T	T	T	0.627	7.773	0.575	N	N	-0.767	0.704	-0.893	0.629	0.004	0.707	0.670	0.725	0.636	.	2.920	1.750	0.027	0.877	0.665	0.000	0.004	0.012	.	.	.	.	.	ZNF514	197	0	337	176	0.34307992202729	TRUE	TRUE
ENSG00000249715.12	.	BCM	GRCh38.p13	chr2	96704678	96704704	+	GCCCCAGGAGACTAATTAGTCCATGCT	GCCCCAGGAGACTAATTAGTCCATGCT	-	Frame_Shift_Del	DEL	ENST00000624922.6	exon53	c.6160_6186del	p.P2055_D2057delinsWLSSCYQQPSPWAGYQFFVSIF	exonic	ENSG00000249715.12	.	frameshift deletion	ENSG00000249715.12:ENST00000624922.6:exon53:c.6160_6186del:p.P2055_D2057delinsWLSSCYQQPSPWAGYQFFVSIF	2q11.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FER1L5	165	0	326	143	0.304904051172708	TRUE	NA
ENSG00000144191.12	.	BCM	GRCh38.p13	chr2	98396675	98396675	+	T	T	A	Missense_Mutation	SNP	ENST00000272602.7	exon8	c.T1505A	p.V502E	exonic	ENSG00000144191.12	.	nonsynonymous SNV	ENSG00000144191.12:ENST00000272602.7:exon8:c.T1505A:p.V502E	2q11.2	C3L-02613	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	L	D	D	0.908	D	D	D	0.866	0.619	0.993	0.649	T	D	D	D	D	D	4.102	27.800	0.990	D	D	0.723	7.459	0.678	7.363	1.000	0.497	0.563	0.547	0.542	.	4.830	4.830	7.671	1.135	0.660	1.000	0.885	0.988	279	Cyclic_nucleotide-binding_domain	.	.	.	CNGA3	451	0	1063	463	0.303407601572739	TRUE	TRUE
ENSG00000153165.19	.	BCM	GRCh38.p13	chr2	106424733	106424733	+	T	T	G	Missense_Mutation	SNP	ENST00000409886.4	exon20	c.A3234C	p.K1078N	exonic	ENSG00000153165.19	.	nonsynonymous SNV	ENSG00000153165.19:ENST00000409886.4:exon20:c.A3234C:p.K1078N	2q12.2	C3L-02613	.	.	.	.	.	.	.	.	.	11.19	D	D	D	D	.	N	M	T	D	0.903	T	T	T	0.320	0.641	0.199	.	D	T	D	T	D	D	3.543	24.800	0.998	D	N	0.346	4.028	0.159	2.989	0.102	0.554	0.588	0.618	0.621	.	2.350	2.350	2.110	1.014	0.309	1.000	1.000	0.976	911	Ran_binding_domain	.	.	.	RGPD3	550	0	936	441	0.320261437908497	NA	TRUE
ENSG00000176601.13	.	BCM	GRCh38.p13	chr2	134987244	134987244	+	T	T	A	Missense_Mutation	SNP	ENST00000392915.6	exon10	c.A1628T	p.K543M	exonic	ENSG00000176601.13	.	nonsynonymous SNV	ENSG00000176601.13:ENST00000392915.6:exon10:c.A1628T:p.K543M	2q21.3	C3L-02613	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	N	0.609	D	D	D	0.274	0.193	0.873	0.617	T	T	D	D	D	T	3.278	24.100	0.993	D	D	0.376	4.196	0.273	3.566	0.995	0.487	0.547	0.574	0.530	.	5.100	5.100	5.918	1.138	0.665	1.000	0.038	0.258	897	.	.	.	.	MAP3K19	164	0	282	139	0.330166270783848	TRUE	TRUE
ENSG00000082438.17	.	BCM	GRCh38.p13	chr2	164728151	164728151	+	A	A	C	Missense_Mutation	SNP	ENST00000375458.6	exon4	c.T479G	p.I160R	exonic	ENSG00000082438.17	.	nonsynonymous SNV	ENSG00000082438.17:ENST00000375458.6:exon4:c.T479G:p.I160R	2q24.3	C3L-02613	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	D	D	0.786	D	D	D	0.823	0.713	0.978	0.417	T	T	D	D	D	D	3.820	25.900	0.989	D	D	0.827	9.327	0.850	11.769	1.000	0.706	0.574	0.574	0.613	.	6.170	6.170	9.325	1.312	0.756	1.000	0.998	0.942	868	Cordon-bleu,_ubiquitin-like_domain	.	.	.	COBLL1	166	0	272	94	0.256830601092896	TRUE	TRUE
ENSG00000136531.17	.	BCM	GRCh38.p13	chr2	165314035	165314035	+	A	A	G	Missense_Mutation	SNP	ENST00000375437.7	exon10	c.A1310G	p.E437G	exonic	ENSG00000136531.17	.	nonsynonymous SNV	ENSG00000136531.17:ENST00000375437.7:exon10:c.A1310G:p.E437G	2q24.3	C3L-02613	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	N	D	M	D	D	0.306	D	D	D	0.790	0.273	0.961	.	T	D	D	D	D	D	3.738	25.600	0.999	D	D	0.897	10.973	0.873	12.662	1.000	0.554	0.574	0.618	0.564	.	5.770	5.770	9.325	1.312	0.756	1.000	0.979	0.992	782	.	.	.	.	SCN2A	229	0	380	109	0.222903885480573	TRUE	TRUE
ENSG00000118997.14	.	BCM	GRCh38.p13	chr2	195934653	195934653	+	T	T	-	Frame_Shift_Del	DEL	ENST00000312428.11	exon21	c.3409delA	p.R1137Efs*11	exonic	ENSG00000118997.14	.	frameshift deletion	ENSG00000118997.14:ENST00000312428.11:exon21:c.3409delA:p.R1137Efs*11	2q32.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH7	189	0	353	24	0.0636604774535809	NA	TRUE
ENSG00000115020.17	.	BCM	GRCh38.p13	chr2	208285811	208285811	+	G	G	C	Missense_Mutation	SNP	ENST00000264380.9	exon6	c.G699C	p.L233F	exonic	ENSG00000115020.17	.	nonsynonymous SNV	ENSG00000115020.17:ENST00000264380.9:exon6:c.G699C:p.L233F	2q34	C3L-02613	8.237e-06	0	0	0	0	1.498e-05	0	0	rs777357869	11.20	D	D	D	D	D	D	L	T	D	0.867	T	T	T	0.144	0.203	0.514	1.025	T	D	T	T	D	D	3.631	25.100	0.999	D	N	0.470	4.809	0.445	4.694	0.895	0.563	0.654	0.609	0.636	.	5.920	3.130	2.212	1.176	0.676	1.000	1.000	0.997	652	.	.	.	.	PIKFYVE	274	0	419	171	0.289830508474576	TRUE	NA
ENSG00000144406.19	.	BCM	GRCh38.p13	chr2	209976283	209976283	+	C	C	T	Missense_Mutation	SNP	ENST00000439458.5	exon56	c.C8554T	p.R2852C	exonic	ENSG00000144406.19	.	nonsynonymous SNV	ENSG00000144406.19:ENST00000439458.5:exon56:c.C8554T:p.R2852C	2q34	C3L-02613	.	.	.	.	.	.	.	.	.	12.19	D	D	D	D	.	D	L	T	N	0.737	T	T	T	0.224	0.548	0.554	1.244	D	T	D	D	D	D	3.785	25.800	0.999	D	D	0.573	5.661	0.609	6.342	0.001	0.487	0.574	0.574	0.530	.	5.850	4.900	3.149	1.026	0.599	1.000	1.000	0.993	748	.	.	.	ID=COSV55897971;OCCURENCE=1(large_intestine),1(stomach)	UNC80	290	0	506	174	0.255882352941176	TRUE	TRUE
ENSG00000163464.8	.	BCM	GRCh38.p13	chr2	218165055	218165055	+	T	T	A	Missense_Mutation	SNP	ENST00000295683.3	exon2	c.A157T	p.S53C	exonic	ENSG00000163464.8	.	nonsynonymous SNV	ENSG00000163464.8:ENST00000295683.3:exon2:c.A157T:p.S53C	2q35	C3L-02613	.	.	.	.	.	.	.	.	.	11.20	D	T	D	D	D	D	M	T	D	0.489	T	T	D	0.266	0.647	0.732	0.405	T	T	T	T	D	T	3.329	24.200	0.991	D	D	0.505	5.076	0.491	5.077	1.000	0.497	0.563	0.590	0.530	.	5.350	5.350	3.250	1.138	0.665	0.932	0.879	0.866	929	.	.	.	.	CXCR1	293	0	721	38	0.0500658761528327	TRUE	TRUE
ENSG00000079263.19	.	BCM	GRCh38.p13	chr2	230253327	230253327	+	T	T	A	Missense_Mutation	SNP	ENST00000392045.8	exon11	c.T1069A	p.S357T	exonic	ENSG00000079263.19	.	nonsynonymous SNV	ENSG00000079263.19:ENST00000392045.8:exon11:c.T1069A:p.S357T	2q37.1	C3L-02613	.	.	.	.	.	.	.	.	.	0.19	T	T	P	B	.	N	N	T	N	0.163	T	T	T	0.063	0.149	0.549	0.080	T	T	T	T	T	T	0.150	2.576	0.303	N	N	-0.615	0.961	-0.809	0.745	0.025	0.672	0.702	0.618	0.530	.	2.550	1.360	0.005	0.011	0.647	0.000	0.001	0.001	834	.	.	.	.	SP140	172	0	281	106	0.27390180878553	NA	TRUE
ENSG00000008300.17	.	BCM	GRCh38.p13	chr3	48660525	48660525	+	C	C	T	Missense_Mutation	SNP	ENST00000164024.5	exon1	c.G2110A	p.A704T	exonic	ENSG00000008300.17	.	nonsynonymous SNV	ENSG00000008300.17:ENST00000164024.5:exon1:c.G2110A:p.A704T	3p21.31	C3L-02613	8.247e-06	0	0	0	0	0	0	6.061e-05	rs767164011	6.19	T	D	D	P	.	D	N	T	N	0.628	T	T	T	0.216	0.386	0.567	1.831	T	T	T	T	T	D	3.027	23.500	0.997	D	D	0.251	3.536	0.321	3.842	1.000	0.635	0.514	0.644	0.621	.	5.950	5.070	4.952	1.026	0.599	1.000	0.996	0.955	3	Cadherin-like	.	.	.	CELSR3	208	0	248	187	0.429885057471264	TRUE	NA
ENSG00000163377.16	.	BCM	GRCh38.p13	chr3	68739071	68739084	+	TTGCCTTCGTAGTT	TTGCCTTCGTAGTT	-	Nonsense_Mutation	DEL	ENST00000295569.12	exon5	c.402_411del	p.T135*	exonic	ENSG00000163377.16	.	stopgain	ENSG00000163377.16:ENST00000295569.12:exon5:c.402_411del:p.T135*	3p14.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TAFA4	170	0	130	94	0.419642857142857	TRUE	TRUE
ENSG00000114544.16	.	BCM	GRCh38.p13	chr3	126068050	126068050	+	G	G	A	Missense_Mutation	SNP	ENST00000315891.10	exon2	c.C170T	p.P57L	exonic	ENSG00000114544.16	.	nonsynonymous SNV	ENSG00000114544.16:ENST00000315891.10:exon2:c.C170T:p.P57L	3q21.2	C3L-02613	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	N	T	D	0.040	T	T	T	0.007	0.326	0.076	0.150	T	T	T	T	T	T	-0.134	0.705	0.410	N	N	-1.320	0.154	-1.291	0.215	0.018	0.732	0.710	0.710	0.728	.	3.950	1.930	-0.025	-0.212	-0.797	0.008	0.007	0.001	825	.	.	.	.	SLC41A3	126	0	282	86	0.233695652173913	TRUE	NA
ENSG00000206384.10	.	BCM	GRCh38.p13	chr3	130565096	130565096	+	G	G	T	Missense_Mutation	SNP	ENST00000358511.10	exon3	c.G764T	p.S255I	exonic	ENSG00000206384.10	.	nonsynonymous SNV	ENSG00000206384.10:ENST00000358511.10:exon3:c.G764T:p.S255I	3q22.1	C3L-02613	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	D	N	N	T	N	0.348	T	T	T	0.368	0.492	0.411	0.392	T	T	T	T	T	T	1.531	15.930	0.576	N	N	-0.625	0.943	-0.411	1.352	0.001	0.487	0.590	0.574	0.564	.	5.090	4.150	1.707	0.217	0.676	0.006	0.377	0.972	670	von_Willebrand_factor,_type_A	.	.	ID=COSV62031119;OCCURENCE=1(kidney)	COL6A6	258	0	420	214	0.337539432176656	TRUE	TRUE
ENSG00000168779.19	.	BCM	GRCh38.p13	chr3	158105866	158105866	+	G	G	T	Missense_Mutation	SNP	ENST00000441443.6	exon1	c.C159A	p.S53R	exonic	ENSG00000168779.19	.	nonsynonymous SNV	ENSG00000168779.19:ENST00000441443.6:exon1:c.C159A:p.S53R	3q25.32	C3L-02613	.	.	.	.	.	.	.	.	.	7.20	T	T	P	P	D	D	N	T	N	0.172	T	D	D	0.272	0.296	0.797	0.894	D	T	T	T	D	T	2.622	22.700	0.971	D	N	-0.219	1.823	-0.163	1.877	1.000	0.437	0.492	0.607	0.555	.	3.900	2.050	1.357	0.151	-0.223	1.000	1.000	0.985	554	.	.	.	.	SHOX2	181	0	524	199	0.275242047026279	TRUE	TRUE
ENSG00000169760.17	.	BCM	GRCh38.p13	chr3	173807769	173807769	+	A	A	T	Missense_Mutation	SNP	ENST00000457714.5	exon4	c.A583T	p.S195C	exonic	ENSG00000169760.17	.	nonsynonymous SNV	ENSG00000169760.17:ENST00000457714.5:exon4:c.A583T:p.S195C	3q26.31	C3L-02613	.	.	.	.	.	.	.	.	.	17.19	D	D	D	D	D	D	.	T	D	0.828	D	D	D	0.784	0.690	0.655	1.113	D	T	D	D	D	D	4.155	28.200	0.994	D	D	0.975	13.167	0.898	13.657	1.000	0.706	0.574	0.653	0.613	.	5.430	5.430	9.325	1.312	0.756	1.000	1.000	0.998	914	Carboxylesterase,_type_B	.	.	.	NLGN1	261	0	652	153	0.190062111801242	TRUE	TRUE
ENSG00000038210.14	.	BCM	GRCh38.p13	chr4	25252406	25252406	+	A	A	T	Missense_Mutation	SNP	ENST00000264864.8	exon2	c.A354T	p.E118D	exonic	ENSG00000038210.14	.	nonsynonymous SNV	ENSG00000038210.14:ENST00000264864.8:exon2:c.A354T:p.E118D	4p15.2	C3L-02613	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	L	T	N	0.113	T	T	T	0.090	0.326	0.503	0.294	T	T	T	T	T	D	1.948	18.860	0.992	N	N	-0.435	1.309	-0.267	1.633	0.999	0.507	0.658	0.659	0.655	.	5.430	3.040	0.963	1.312	0.691	0.824	1.000	0.998	676	.	.	.	.	PI4K2B	135	0	97	72	0.42603550295858	TRUE	TRUE
ENSG00000163288.14	.	BCM	GRCh38.p13	chr4	47403438	47403438	+	A	A	T	Missense_Mutation	SNP	ENST00000295454.8	exon6	c.A665T	p.K222M	exonic	ENSG00000163288.14	.	nonsynonymous SNV	ENSG00000163288.14:ENST00000295454.8:exon6:c.A665T:p.K222M	4p12	C3L-02613	.	.	.	.	.	.	.	.	.	7.20	T	T	D	P	N	D	N	T	N	0.421	T	T	D	0.402	0.507	0.866	1.837	T	T	T	T	D	D	3.656	25.200	0.982	D	D	0.189	3.254	0.344	3.983	0.272	0.487	0.574	0.574	0.530	.	5.430	5.430	6.116	1.312	0.756	1.000	1.000	1.000	793	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	.	GABRB1	99	0	159	76	0.323404255319149	TRUE	TRUE
ENSG00000132466.19	.	BCM	GRCh38.p13	chr4	73091136	73091136	+	C	C	T	Missense_Mutation	SNP	ENST00000358602.9	exon29	c.G6492A	p.M2164I	exonic	ENSG00000132466.19	.	nonsynonymous SNV	ENSG00000132466.19:ENST00000358602.9:exon29:c.G6492A:p.M2164I	4q13.3	C3L-02613	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	D	N	N	T	N	0.196	T	T	T	0.070	0.130	0.403	0.329	T	T	T	T	T	T	1.510	15.800	0.787	D	N	-0.138	2.056	0.052	2.547	0.989	0.707	0.702	0.702	0.714	.	5.070	5.070	0.282	0.130	0.599	0.197	1.000	0.998	778	.	.	.	.	ANKRD17	234	0	504	234	0.317073170731707	TRUE	TRUE
ENSG00000138685.16	.	BCM	GRCh38.p13	chr4	122827307	122827307	+	C	C	T	Missense_Mutation	SNP	ENST00000644866.2	exon1	c.C133T	p.P45S	exonic	ENSG00000138685.16	.	nonsynonymous SNV	ENSG00000138685.16:ENST00000644866.2:exon1:c.C133T:p.P45S	4q28.1	C3L-02613	.	.	.	.	.	.	.	.	.	7.19	D	T	P	P	N	.	L	D	D	0.118	T	T	D	0.335	0.596	0.777	.	T	D	T	T	D	D	3.027	23.500	0.987	N	N	0.025	2.603	0.043	2.511	1.000	0.733	0.219	0.601	0.373	.	3.560	3.560	1.366	0.946	0.504	0.712	0.998	0.589	511	.	.	.	.	FGF2	174	0	195	202	0.508816120906801	TRUE	TRUE
ENSG00000174358.16	.	BCM	GRCh38.p13	chr5	1219600	1219600	+	A	A	T	Missense_Mutation	SNP	ENST00000304460.11	exon10	c.A1474T	p.I492F	exonic	ENSG00000174358.16	.	nonsynonymous SNV	ENSG00000174358.16:ENST00000304460.11:exon10:c.A1474T:p.I492F	5p15.33	C3L-02613	.	.	.	.	.	.	.	.	.	9.20	T	T	P	B	D	D	L	T	N	0.445	T	T	D	0.461	0.342	0.614	0.503	T	T	D	D	D	D	2.346	21.800	0.709	D	D	-0.164	1.981	-0.120	1.990	1.000	0.497	0.590	0.578	0.563	.	4.830	3.670	2.274	1.239	0.677	0.998	0.674	0.674	923	.	.	.	.	SLC6A19	301	0	801	667	0.454359673024523	TRUE	TRUE
ENSG00000154162.15	.	BCM	GRCh38.p13	chr5	21751883	21751883	+	C	C	T	Missense_Mutation	SNP	ENST00000382254.6	exon15	c.G2239A	p.V747M	exonic	ENSG00000154162.15	.	nonsynonymous SNV	ENSG00000154162.15:ENST00000382254.6:exon15:c.G2239A:p.V747M	5p14.3	C3L-02613	8.241e-06	0	0	0	0	1.499e-05	0	0	rs763180534	7.20	D	T	P	B	N	D	M	T	N	0.494	T	D	D	0.350	0.524	0.765	0.774	T	T	T	T	T	D	1.497	15.720	0.996	D	N	-0.183	1.924	-0.389	1.391	0.089	0.554	0.574	0.574	0.621	.	4.940	0.576	1.840	0.129	0.549	0.185	0.002	0.086	853	Cadherin,_cytoplasmic_domain	.	.	ID=COSV66389256;OCCURENCE=1(breast),1(large_intestine),1(upper_aerodigestive_tract)	CDH12	376	0	1162	77	0.0621468926553672	TRUE	TRUE
ENSG00000113389.16	.	BCM	GRCh38.p13	chr5	32712278	32712278	+	G	G	A	Missense_Mutation	SNP	ENST00000265074.13	exon1	c.G502A	p.D168N	exonic	ENSG00000113389.16	.	nonsynonymous SNV	ENSG00000113389.16:ENST00000265074.13:exon1:c.G502A:p.D168N	5p13.3	C3L-02613	.	.	.	.	.	.	.	.	.	5.20	T	T	B	B	N	D	N	D	N	0.090	T	T	D	0.230	0.330	0.857	.	T	T	T	T	T	D	2.379	22.000	0.995	D	N	-0.361	1.470	-0.132	1.959	1.000	0.437	0.563	0.607	0.555	.	4.890	4.890	1.490	1.172	0.672	0.997	0.996	0.952	844	Receptor,_ligand_binding_region	.	.	ID=COSV54090080;OCCURENCE=1(skin)	NPR3	140	0	394	245	0.383411580594679	TRUE	TRUE
ENSG00000168724.17	.	BCM	GRCh38.p13	chr5	34950315	34950315	+	G	G	T	Missense_Mutation	SNP	ENST00000648817.1	exon10	c.G1331T	p.C444F	exonic	ENSG00000168724.17	.	nonsynonymous SNV	ENSG00000168724.17:ENST00000648817.1:exon10:c.G1331T:p.C444F	5p13.2	C3L-02613	.	.	.	.	.	.	.	.	.	4.20	D	T	D	P	N	N	M	T	N	0.259	T	T	T	0.081	0.141	0.574	0.316	T	T	T	T	D	T	3.444	24.500	0.904	N	N	-0.003	2.500	0.006	2.380	0.999	0.707	0.725	0.725	0.714	.	5.670	3.820	1.132	1.176	0.618	0.423	0.798	0.996	554	.	.	.	.	DNAJC21	89	0	247	20	0.0749063670411985	TRUE	TRUE
ENSG00000053108.17	.	BCM	GRCh38.p13	chr5	133400923	133400923	+	C	C	T	Missense_Mutation	SNP	ENST00000265342.12	exon4	c.G224A	p.R75Q	exonic	ENSG00000053108.17	.	nonsynonymous SNV	ENSG00000053108.17:ENST00000265342.12:exon4:c.G224A:p.R75Q	5q31.1	C3L-02613	0.0001	0.0007	0.0004	0	0	1.547e-05	0	0	rs368837848	1.20	T	T	B	B	N	N	L	T	N	0.116	T	T	T	0.033	.	0.372	0.262	T	T	T	T	T	D	1.390	15.020	0.993	N	N	-0.646	0.905	-0.519	1.171	0.983	0.497	0.547	0.299	0.542	.	5.570	2.420	0.877	-0.723	-0.823	0.053	0.057	0.853	714	.	.	.	ID=COSV54769570;OCCURENCE=1(lung)	FSTL4	215	0	483	212	0.305035971223022	TRUE	TRUE
ENSG00000239389.8	.	BCM	GRCh38.p13	chr5	140883337	140883337	+	C	C	G	Missense_Mutation	SNP	ENST00000289272.3	exon1	c.C1069G	p.L357V	exonic	ENSG00000239389.8	.	nonsynonymous SNV	ENSG00000239389.8:ENST00000289272.3:exon1:c.C1069G:p.L357V	5q31.3	C3L-02613	.	.	.	.	.	.	.	.	.	1.18	T	T	B	B	.	N	N	T	D	0.124	T	T	T	0.028	0.411	0.390	.	.	T	T	T	T	T	1.163	13.340	0.866	N	N	-0.772	0.696	-0.737	0.846	0.851	0.646	0.574	0.645	0.567	.	5.440	1.640	-0.675	1.026	0.599	0.000	0.890	0.984	74	.	.	.	.	PCDHA13	161	0	351	141	0.286585365853659	TRUE	TRUE
ENSG00000070814.22	.	BCM	GRCh38.p13	chr5	150396320	150396320	+	T	T	G	Missense_Mutation	SNP	ENST00000377797.7	exon24	c.T3820G	p.S1274A	exonic	ENSG00000070814.22	.	nonsynonymous SNV	ENSG00000070814.22:ENST00000377797.7:exon24:c.T3820G:p.S1274A	5q32	C3L-02613	.	.	.	.	.	.	.	.	.	1.20	D	T	P	B	N	N	N	T	N	0.120	T	T	T	0.093	0.105	0.103	0.070	T	T	T	T	T	T	1.478	15.600	0.986	N	N	-0.849	0.586	-0.781	0.784	0.454	0.707	0.702	0.702	0.714	.	4.540	0.521	-0.124	0.100	-0.272	0.963	0.870	0.448	856	.	.	.	.	TCOF1	292	2	588	274	0.317865429234339	TRUE	TRUE
ENSG00000183072.10	.	BCM	GRCh38.p13	chr5	173234875	173234875	+	C	C	T	Missense_Mutation	SNP	ENST00000329198.5	exon1	c.G209A	p.R70H	exonic	ENSG00000183072.10	.	nonsynonymous SNV	ENSG00000183072.10:ENST00000329198.5:exon1:c.G209A:p.R70H	5q35.1	C3L-02613	.	.	.	.	.	.	.	.	.	7.20	T	T	D	P	N	N	L	D	N	0.289	T	D	D	0.225	0.225	0.773	1.550	T	T	T	T	D	D	2.067	19.770	0.999	D	N	-0.161	1.989	-0.231	1.714	1.000	0.598	0.563	0.607	0.639	.	4.590	3.700	0.462	0.962	0.524	0.002	0.748	0.282	872	.	.	.	ID=COSV61299276;OCCURENCE=1(prostate)	NKX2-5	70	0	428	26	0.0572687224669604	TRUE	TRUE
ENSG00000204520.14	.	BCM	GRCh38.p13	chr6	31411287	31411287	+	C	C	A	Missense_Mutation	SNP	ENST00000449934.7	exon3	c.C541A	p.H181N	exonic	ENSG00000204520.14	.	nonsynonymous SNV	ENSG00000204520.14:ENST00000449934.7:exon3:c.C541A:p.H181N	6p21.33	C3L-02613	.	.	.	.	.	.	.	.	.	1.17	D	T	B	B	U	N	.	T	N	0.146	T	T	T	0.033	0.303	0.014	0.213	T	.	T	T	T	.	0.039	1.599	0.532	N	N	-1.647	0.045	-1.810	0.032	0.850	0.722	0.725	0.725	0.735	.	1.410	-2.820	-0.482	-0.458	-1.453	0.000	0.000	0.000	934	MHC_class_I-like_antigen_recognition-like	.	.	.	MICA	180	0	445	153	0.255852842809365	NA	TRUE
ENSG00000111886.11	.	BCM	GRCh38.p13	chr6	89265631	89265631	+	G	G	T	Missense_Mutation	SNP	ENST00000402938.4	exon7	c.C871A	p.P291T	exonic	ENSG00000111886.11	.	nonsynonymous SNV	ENSG00000111886.11:ENST00000402938.4:exon7:c.C871A:p.P291T	6q15	C3L-02613	.	.	.	.	.	.	.	.	.	15.16	.	D	.	.	D	D	M	D	.	0.965	D	D	D	0.900	.	0.974	0.684	T	D	D	D	D	D	4.073	27.500	0.997	D	D	1.034	15.040	0.984	17.892	1.000	0.549	0.588	0.602	0.616	.	5.830	5.830	9.968	1.176	0.676	1.000	0.998	0.963	905	Neurotransmitter-gated_ion-channel_transmembrane_domain	.	.	.	GABRR2	122	0	108	93	0.462686567164179	TRUE	TRUE
ENSG00000112299.8	.	BCM	GRCh38.p13	chr6	132694071	132694071	+	-	NA	T	Frame_Shift_Ins	NA	ENST00000367928.5	exon3	c.452dupA	p.C152Vfs*4	exonic	ENSG00000112299.8	.	frameshift insertion	ENSG00000112299.8:ENST00000367928.5:exon3:c.452dupA:p.C152Vfs*4	6q23.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	VNN1	NA	NA	NA	NA	NA	NA	NA
ENSG00000131016.17	.	BCM	GRCh38.p13	chr6	151352625	151352625	+	G	G	A	Missense_Mutation	SNP	ENST00000402676.7	exon4	c.G4234A	p.V1412I	exonic	ENSG00000131016.17	.	nonsynonymous SNV	ENSG00000131016.17:ENST00000402676.7:exon4:c.G4234A:p.V1412I	6q25.1	C3L-02613	8.257e-06	9.733e-05	0	0	0	0	0	0	rs569396619	2.20	D	T	B	B	N	N	L	T	N	0.072	T	T	T	0.033	.	0.326	0.135	T	T	T	T	D	T	1.430	15.280	0.978	N	N	-0.728	0.766	-0.731	0.856	1.000	0.737	0.616	0.733	0.735	.	4.860	2.960	1.437	1.176	0.676	0.003	0.608	0.179	928	.	.	.	.	AKAP12	142	0	334	38	0.102150537634409	TRUE	NA
ENSG00000180347.13	.	BCM	GRCh38.p13	chr7	31553175	31553175	+	A	A	G	Missense_Mutation	SNP	ENST00000407970.7	exon2	c.A151G	p.I51V	exonic	ENSG00000180347.13	.	nonsynonymous SNV	ENSG00000180347.13:ENST00000407970.7:exon2:c.A151G:p.I51V	7p14.3	C3L-02613	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	.	T	N	0.037	T	T	T	0.005	0.160	0.040	0.028	T	T	T	T	T	T	-0.782	0.028	0.566	N	N	-1.080	0.324	-1.149	0.327	0.000	0.487	0.574	0.547	0.564	.	5.120	-1.640	-0.460	-0.049	-0.041	0.000	0.001	0.003	866	.	.	.	.	ITPRID1	86	0	176	64	0.266666666666667	TRUE	NA
ENSG00000127980.16	.	BCM	GRCh38.p13	chr7	92522125	92522125	+	G	G	T	Missense_Mutation	SNP	ENST00000248633.9	exon2	c.C250A	p.L84I	exonic	ENSG00000127980.16	.	nonsynonymous SNV	ENSG00000127980.16:ENST00000248633.9:exon2:c.C250A:p.L84I	7q21.2	C3L-02613	.	.	.	.	.	.	.	.	.	16.20	D	T	D	D	D	D	M	D	N	0.545	D	D	D	0.600	0.695	0.875	0.702	T	T	D	D	D	D	3.816	25.900	0.996	D	D	0.878	10.494	0.885	13.125	1.000	0.706	0.634	0.710	0.655	.	6.030	6.030	7.753	1.176	0.676	1.000	1.000	0.993	798	Peroxisome_biogenesis_factor_1,_N-terminal,_alpha/beta	.	.	.	PEX1	266	0	521	40	0.071301247771836	TRUE	TRUE
ENSG00000105967.16	.	BCM	GRCh38.p13	chr7	115974199	115974199	+	C	C	G	Missense_Mutation	SNP	ENST00000265440.12	exon3	c.G238C	p.A80P	exonic	ENSG00000105967.16	.	nonsynonymous SNV	ENSG00000105967.16:ENST00000265440.12:exon3:c.G238C:p.A80P	7q31.2	C3L-02613	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	U	D	N	T	N	0.319	T	T	T	0.020	0.340	0.267	0.048	T	T	T	T	T	T	1.506	15.770	0.970	D	N	-0.879	0.547	-0.741	0.841	0.257	0.693	0.588	0.574	0.564	.	4.770	-2.880	0.551	-0.195	-0.169	0.995	0.980	0.994	730	.	.	.	.	TFEC	106	0	136	40	0.227272727272727	TRUE	TRUE
ENSG00000064419.13	.	BCM	GRCh38.p13	chr7	129017007	129017007	+	C	C	T	Missense_Mutation	SNP	ENST00000265388.9	exon3	c.G371A	p.G124E	exonic	ENSG00000064419.13	.	nonsynonymous SNV	ENSG00000064419.13:ENST00000265388.9:exon3:c.G371A:p.G124E	7q32.1	C3L-02613	.	.	.	.	.	.	.	.	.	10.20	T	T	B	B	D	D	L	T	N	0.870	T	T	D	0.273	0.750	0.771	1.613	D	T	D	D	D	D	2.003	19.280	0.692	D	D	0.043	2.667	0.257	3.474	1.000	0.732	0.658	0.744	0.728	.	5.810	5.810	7.852	1.026	0.599	1.000	1.000	0.998	431	Exportin-1/Importin-beta-like	.	.	.	TNPO3	233	0	365	126	0.256619144602851	TRUE	TRUE
ENSG00000129422.14	.	BCM	GRCh38.p13	chr8	17754363	17754378	+	GATTTTCCTAAACTGG	GATTTTCCTAAACTGG	-	Frame_Shift_Del	DEL	ENST00000262102.10	exon2	c.1430_1445del	p.P477Qfs*9	exonic	ENSG00000129422.14	.	frameshift deletion	ENSG00000129422.14:ENST00000262102.10:exon2:c.1430_1445del:p.P477Qfs*9	8p22	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MTUS1	274	0	242	177	0.422434367541766	TRUE	TRUE
ENSG00000253729.8	.	BCM	GRCh38.p13	chr8	47776977	47776977	+	C	C	G	Missense_Mutation	SNP	ENST00000314191.7	exon85	c.G12049C	p.E4017Q	exonic	ENSG00000253729.8	.	nonsynonymous SNV	ENSG00000253729.8:ENST00000314191.7:exon85:c.G12049C:p.E4017Q	8q11.21	C3L-02613	8.329e-06	0	8.645e-05	0	0	0	0	0	rs375321876	11.17	.	D	D	P	D	D	M	.	.	0.354	D	D	T	0.396	0.340	0.834	0.675	T	T	T	T	D	D	3.653	25.200	0.998	D	D	0.699	7.106	0.718	8.096	1.000	0.707	0.725	0.725	0.714	.	5.620	5.620	7.482	1.001	0.587	1.000	0.986	0.968	620	Phosphatidylinositol_3-/4-kinase,_catalytic_domain	.	.	.	PRKDC	78	0	96	66	0.407407407407407	TRUE	NA
ENSG00000175073.8	.	BCM	GRCh38.p13	chr8	66666729	66666729	+	T	T	G	Missense_Mutation	SNP	ENST00000310421.5	exon1	c.A230C	p.H77P	exonic	ENSG00000175073.8	.	nonsynonymous SNV	ENSG00000175073.8:ENST00000310421.5:exon1:c.A230C:p.H77P	8q13.1	C3L-02613	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.777	T	T	D	0.471	0.380	0.472	2.042	T	T	D	D	D	T	4.207	28.700	0.969	D	D	0.794	8.661	0.798	10.066	1.000	0.405	0.484	0.686	0.373	.	5.930	5.930	7.602	1.138	0.665	1.000	1.000	0.998	654	.	.	.	.	VCPIP1	85	0	231	90	0.280373831775701	TRUE	TRUE
ENSG00000104218.14	.	BCM	GRCh38.p13	chr8	67132007	67132007	+	G	G	C	Missense_Mutation	SNP	ENST00000262210.9	exon14	c.G1739C	p.G580A	exonic	ENSG00000104218.14	.	nonsynonymous SNV	ENSG00000104218.14:ENST00000262210.9:exon14:c.G1739C:p.G580A	8q13.2	C3L-02613	.	.	.	.	.	.	.	.	.	8.18	D	T	D	P	N	D	.	T	D	0.600	T	T	T	0.227	.	0.675	0.543	T	.	D	T	D	T	2.960	23.300	0.989	D	D	0.471	4.816	0.509	5.240	1.000	0.732	0.709	0.744	0.684	.	5.300	5.300	5.118	1.176	0.618	1.000	0.953	0.696	714	.	.	.	.	CSPP1	66	0	119	11	0.0846153846153846	TRUE	TRUE
ENSG00000091656.19	.	BCM	GRCh38.p13	chr8	76863115	76863121	+	GCATGCT	GCATGCT	-	Frame_Shift_Del	DEL	ENST00000651372.2	exon11	c.9401_9407del	p.G3134Vfs*64	exonic	ENSG00000091656.19	.	frameshift deletion	ENSG00000091656.19:ENST00000651372.2:exon11:c.9401_9407del:p.G3134Vfs*64	8q21.13	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZFHX4	57	0	52	28	0.35	TRUE	TRUE
ENSG00000164796.18	.	BCM	GRCh38.p13	chr8	112265486	112265486	+	T	T	C	Missense_Mutation	SNP	ENST00000297405.10	exon60	c.A9613G	p.M3205V	exonic	ENSG00000164796.18	.	nonsynonymous SNV	ENSG00000164796.18:ENST00000297405.10:exon60:c.A9613G:p.M3205V	8q23.3	C3L-02613	8.241e-06	0	0	0	0	1.499e-05	0	0	rs762522299	10.20	D	D	B	B	D	D	L	T	D	0.732	T	T	T	0.250	.	0.749	0.233	T	T	D	T	D	D	2.633	22.700	0.944	D	D	-0.045	2.355	0.072	2.621	0.123	0.487	0.574	0.547	0.564	.	5.440	4.250	5.024	1.138	0.609	1.000	0.484	0.711	865	Sushi/SCR/CCP_domain	.	.	ID=COSV52331748;OCCURENCE=1(lung)	CSMD3	255	0	469	65	0.121722846441948	TRUE	TRUE
ENSG00000107338.10	.	BCM	GRCh38.p13	chr9	37948688	37948688	+	G	G	T	Missense_Mutation	SNP	ENST00000377707.4	exon5	c.C1293A	p.S431R	exonic	ENSG00000107338.10	.	nonsynonymous SNV	ENSG00000107338.10:ENST00000377707.4:exon5:c.C1293A:p.S431R	9p13.1	C3L-02613	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.971	D	D	D	0.852	0.708	0.956	0.996	D	D	D	D	D	D	3.900	26.300	0.998	D	D	0.631	6.258	0.563	5.786	1.000	0.706	0.710	0.644	0.714	.	5.110	4.210	4.353	1.106	0.596	1.000	1.000	0.998	674	SHB,_SH2_domain;SH2_domain	.	.	.	SHB	203	0	475	146	0.235104669887279	TRUE	TRUE
ENSG00000273514.1	.	BCM	GRCh38.p13	chr9	41127545	41127545	+	C	C	T	Missense_Mutation	SNP	ENST00000622588.1	exon1	c.G839A	p.G280E	exonic	ENSG00000273514.1	.	nonsynonymous SNV	ENSG00000273514.1:ENST00000622588.1:exon1:c.G839A:p.G280E	9p11.2	C3L-02613	.	.	.	.	.	.	.	.	.	0.4	.	T	.	.	.	.	.	.	.	0.054	.	.	.	.	.	.	.	.	T	.	.	.	T	-0.129	0.721	.	.	N	.	.	.	.	.	.	.	.	.	.	.	.	0.091	-0.400	-0.919	0.000	0.000	0.009	994	.	.	.	.	FOXD4L6	142	0	413	24	0.0549199084668192	NA	TRUE
ENSG00000204779.2	.	BCM	GRCh38.p13	chr9	65283539	65283539	+	C	C	T	Missense_Mutation	SNP	ENST00000377420.1	exon1	c.G839A	p.G280E	exonic	ENSG00000204779.2	.	nonsynonymous SNV	ENSG00000204779.2:ENST00000377420.1:exon1:c.G839A:p.G280E	9q21.11	C3L-02613	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	N	N	D	N	0.022	T	T	D	0.167	0.426	0.148	.	T	T	T	T	T	T	-0.295	0.319	0.868	N	N	-1.425	0.107	-1.489	0.112	0.000	0.487	0.574	0.590	0.542	.	.	.	-1.032	-0.400	-0.935	0.000	0.000	0.010	.	.	.	.	.	FOXD4L5	672	0	1511	297	0.164269911504425	NA	TRUE
ENSG00000165757.9	.	BCM	GRCh38.p13	chr10	30027270	30027270	+	C	C	T	Missense_Mutation	SNP	ENST00000375377.2	exon3	c.G2878A	p.E960K	exonic	ENSG00000165757.9	.	nonsynonymous SNV	ENSG00000165757.9:ENST00000375377.2:exon3:c.G2878A:p.E960K	10p11.23	C3L-02613	.	.	.	.	.	.	.	.	.	3.20	D	D	P	B	N	N	L	T	N	0.123	T	T	T	0.055	0.371	0.204	0.216	T	T	T	T	D	T	2.095	19.980	0.998	N	N	-0.193	1.897	-0.281	1.603	1.000	0.731	0.552	0.660	0.649	.	5.170	4.270	3.114	0.941	0.599	0.396	0.017	0.003	975	.	.	.	.	JCAD	275	0	333	270	0.447761194029851	TRUE	TRUE
ENSG00000148498.16	.	BCM	GRCh38.p13	chr10	34119718	34119718	+	T	T	G	Missense_Mutation	SNP	ENST00000374789.8	exon24	c.A3572C	p.Q1191P	exonic	ENSG00000148498.16	.	nonsynonymous SNV	ENSG00000148498.16:ENST00000374789.8:exon24:c.A3572C:p.Q1191P	10p11.22	C3L-02613	.	.	.	.	.	.	.	.	.	6.20	T	T	D	D	N	D	N	T	N	0.390	T	T	T	0.098	0.179	0.429	0.104	T	T	T	T	D	D	3.036	23.500	0.976	D	N	0.072	2.776	0.100	2.736	0.953	0.706	0.588	0.710	0.655	.	5.400	4.220	4.573	1.135	0.665	1.000	0.896	0.340	927	.	.	.	.	PARD3	93	0	160	140	0.466666666666667	TRUE	TRUE
ENSG00000107736.21	.	BCM	GRCh38.p13	chr10	71803262	71803262	+	C	C	A	Missense_Mutation	SNP	ENST00000224721.12	exon55	c.C7714A	p.Q2572K	exonic	ENSG00000107736.21	.	nonsynonymous SNV	ENSG00000107736.21:ENST00000224721.12:exon55:c.C7714A:p.Q2572K	10q22.1	C3L-02613	.	.	.	.	.	.	.	.	.	5.20	T	D	B	B	D	D	N	T	N	0.312	T	T	T	0.049	0.705	0.595	0.185	T	T	T	T	T	T	2.095	19.980	0.954	D	D	-0.253	1.732	-0.066	2.146	1.000	0.497	0.547	0.590	0.542	.	5.020	4.110	3.030	1.026	0.589	1.000	1.000	0.998	807	Cadherin-like	.	.	.	CDH23	223	0	708	58	0.0757180156657963	TRUE	NA
ENSG00000184698.5	.	BCM	GRCh38.p13	chr11	5390245	5390245	+	G	G	A	Missense_Mutation	SNP	ENST00000642046.1	exon3	c.G847A	p.A283T	exonic	ENSG00000184698.5	.	nonsynonymous SNV	ENSG00000184698.5:ENST00000642046.1:exon3:c.G847A:p.A283T	11p15.4	C3L-02613	4.154e-05	0	0.0004	0	0	0	0	0	rs779170296	0.18	T	T	.	.	U	N	L	T	N	0.122	T	T	T	0.039	.	0.072	0.011	T	T	T	T	T	T	1.700	17.030	0.927	N	N	-0.812	0.638	-0.775	0.794	0.064	0.526	0.616	0.616	0.584	.	5.240	2.150	0.210	0.217	-0.107	0.000	0.002	0.001	706	GPCR,_rhodopsin-like,_7TM	.	.	.	OR51M1	177	1	231	135	0.368852459016393	TRUE	NA
ENSG00000135372.9	.	BCM	GRCh38.p13	chr11	34141164	34141164	+	C	C	T	Nonsense_Mutation	SNP	ENST00000257829.8	exon25	c.C2668T	p.Q890X	exonic	ENSG00000135372.9	.	stopgain	ENSG00000135372.9:ENST00000257829.8:exon25:c.C2668T:p.Q890X	11p13	C3L-02613	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.453	.	.	.	.	.	.	.	.	.	D	D	.	.	8.292	42	0.998	D	N	1.180	22.046	1.045	21.952	1.000	0.707	0.725	0.725	0.714	.	5.650	5.650	7.903	1.026	0.597	1.000	0.980	0.986	338	Possible_tRNA_binding_domain	.	.	.	NAT10	217	0	463	118	0.203098106712565	TRUE	NA
ENSG00000175216.15	.	BCM	GRCh38.p13	chr11	46796832	46796832	+	C	C	G	Missense_Mutation	SNP	ENST00000529230.6	exon12	c.G1447C	p.D483H	exonic	ENSG00000175216.15	.	nonsynonymous SNV	ENSG00000175216.15:ENST00000529230.6:exon12:c.G1447C:p.D483H	11p11.2	C3L-02613	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.903	T	T	D	0.607	0.634	0.817	0.660	T	D	D	D	D	D	4.101	27.800	0.996	D	D	0.898	10.996	0.855	11.949	1.000	0.707	0.725	0.725	0.714	.	5.290	5.290	7.776	0.947	0.599	1.000	1.000	0.999	12	TOG_domain	.	.	.	CKAP5	139	0	214	130	0.377906976744186	TRUE	TRUE
ENSG00000131620.17	.	BCM	GRCh38.p13	chr11	70170982	70171010	+	GCCAAAAAGTTTGTCACTGAGCTCCGAAG	GCCAAAAAGTTTGTCACTGAGCTCCGAAG	-	Frame_Shift_Del	DEL	ENST00000355303.9	exon22	c.2293_2321del	p.K766Gfs*35	exonic	ENSG00000131620.17	.	frameshift deletion	ENSG00000131620.17:ENST00000355303.9:exon22:c.2293_2321del:p.K766Gfs*35	11q13.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANO1	183	0	427	69	0.139112903225806	TRUE	TRUE
ENSG00000137491.15	.	BCM	GRCh38.p13	chr11	75203335	75203349	+	CAGCGCCATCGACAC	CAGCGCCATCGACAC	-	In_Frame_Del	DEL	ENST00000289575.10	exon13	c.1857_1871del	p.S620_T624del	exonic	ENSG00000137491.15	.	nonframeshift deletion	ENSG00000137491.15:ENST00000289575.10:exon13:c.1857_1871del:p.S620_T624del	11q13.4	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLCO2B1	160	0	520	45	0.079646017699115	TRUE	TRUE
ENSG00000137474.22	.	BCM	GRCh38.p13	chr11	77162265	77162265	+	G	G	C	Missense_Mutation	SNP	ENST00000409709.9	exon13	c.G1489C	p.D497H	exonic	ENSG00000137474.22	.	nonsynonymous SNV	ENSG00000137474.22:ENST00000409709.9:exon13:c.G1489C:p.D497H	11q13.5	C3L-02613	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.889	D	D	D	0.882	0.793	0.978	0.506	T	D	D	D	D	D	4.260	29.200	0.996	D	D	0.997	13.838	0.935	15.350	1.000	0.603	0.549	0.602	0.563	.	5.390	5.390	10.003	1.175	0.618	1.000	1.000	0.987	569	Myosin_head,_motor_domain;Class_VII_myosin,_motor_domain	.	.	.	MYO7A	303	0	591	179	0.232467532467532	TRUE	TRUE
ENSG00000178795.9	.	BCM	GRCh38.p13	chr11	77271317	77271317	+	A	A	C	Missense_Mutation	SNP	ENST00000376217.6	exon5	c.T284G	p.L95R	exonic	ENSG00000178795.9	.	nonsynonymous SNV	ENSG00000178795.9:ENST00000376217.6:exon5:c.T284G:p.L95R	11q13.5	C3L-02613	.	.	.	.	.	.	.	.	.	0.20	T	T	P	P	N	N	L	T	N	0.466	T	T	T	0.283	0.532	0.230	0.077	T	T	T	T	T	T	2.253	21.300	0.347	N	N	-0.391	1.402	-0.455	1.276	0.001	0.554	0.574	0.618	0.530	.	4.380	1.850	1.544	0.302	-0.127	0.943	0.521	0.751	425	.	.	.	.	GDPD4	185	0	328	92	0.219047619047619	TRUE	TRUE
ENSG00000137707.13	.	BCM	GRCh38.p13	chr11	111497305	111497305	+	G	G	C	Nonsense_Mutation	SNP	ENST00000356018.6	exon4	c.C416G	p.S139X	exonic	ENSG00000137707.13	.	stopgain	ENSG00000137707.13:ENST00000356018.6:exon4:c.C416G:p.S139X	11q23.1	C3L-02613	.	.	.	.	.	.	.	.	.	3.6	.	.	.	.	N	D	.	.	.	0.303	.	.	.	.	.	.	.	.	.	D	D	.	.	4.197	28.600	0.923	N	N	-0.085	2.224	-0.444	1.294	0.003	0.554	0.563	0.602	0.564	.	5.360	0.044	0.750	-0.150	-0.116	0.000	0.001	0.040	162	.	.	.	.	BTG4	69	1	131	8	0.0575539568345324	TRUE	TRUE
ENSG00000052126.14	.	BCM	GRCh38.p13	chr12	19274598	19274598	+	A	A	T	Missense_Mutation	SNP	ENST00000299275.10	exon10	c.A910T	p.I304F	exonic	ENSG00000052126.14	.	nonsynonymous SNV	ENSG00000052126.14:ENST00000299275.10:exon10:c.A910T:p.I304F	12p12.3	C3L-02613	.	.	.	.	.	.	.	.	.	5.20	D	D	B	B	N	D	L	T	N	0.214	T	T	T	0.014	0.294	0.082	0.085	T	T	T	T	T	D	1.940	18.800	0.419	D	N	-0.562	1.058	-0.461	1.266	1.000	0.732	0.588	0.744	0.563	.	5.300	1.070	0.683	-0.279	-0.050	0.715	0.982	0.980	786	.	.	.	.	PLEKHA5	186	1	148	107	0.419607843137255	TRUE	TRUE
ENSG00000133703.13	.	BCM	GRCh38.p13	chr12	25245350	25245350	+	C	C	A	Missense_Mutation	SNP	ENST00000256078.10	exon2	c.G35T	p.G12V	exonic	ENSG00000133703.13	.	nonsynonymous SNV	ENSG00000133703.13:ENST00000256078.10:exon2:c.G35T:p.G12V	12p12.1	C3L-02613	.	.	.	.	.	.	.	.	rs121913529	18.20	D	D	D	D	D	D	L	T	D	0.939	D	D	D	0.910	0.767	0.989	2.351	D	D	D	D	D	D	3.784	25.800	0.998	D	D	0.948	12.354	0.902	13.818	1.000	0.732	0.710	0.744	0.632	.	5.680	5.680	7.892	1.010	0.580	1.000	1.000	1.000	707	Small_GTP-binding_protein_domain	.	.	ID=COSV55497419;OCCURENCE=21(breast),1(female_genital_tract_(site_indeterminate)),7(liver),36(peritoneum),9(genital_tract),7(oesophagus),25(cervix),5747(large_intestine),1(central_nervous_system),189(biliary_tract),2(pleura),1(vulva),341(ovary),20(NS),45(stomach),96(haematopoietic_and_lymphoid_tissue),8(kidney),9(soft_tissue),32(urinary_tract),2142(pancreas),1(autonomic_ganglia),11(gastrointestinal_tract_(site_indeterminate)),30(skin),43(prostate),1580(lung),25(thyroid),5(upper_aerodigestive_tract),24(testis),1(eye),4(thymus),42(small_intestine),165(endometrium)	KRAS	219	0	362	338	0.482857142857143	TRUE	TRUE
ENSG00000139209.16	.	BCM	GRCh38.p13	chr12	46777002	46777002	+	C	C	T	Missense_Mutation	SNP	ENST00000266579.9	exon13	c.G1076A	p.R359Q	exonic	ENSG00000139209.16	.	nonsynonymous SNV	ENSG00000139209.16:ENST00000266579.9:exon13:c.G1076A:p.R359Q	12q13.11	C3L-02613	.	.	.	.	.	.	.	.	.	10.20	D	T	D	D	D	D	M	T	N	0.623	T	T	T	0.261	0.501	0.171	0.989	T	T	T	T	D	D	3.650	25.200	0.999	D	D	0.738	7.678	0.703	7.808	1.000	0.693	0.547	0.659	0.621	.	5.960	5.960	4.038	1.026	0.599	1.000	0.841	0.666	550	Amino_acid_transporter,_transmembrane_domain	.	.	ID=COSV56969984;OCCURENCE=1(oesophagus)	SLC38A4	171	0	154	154	0.5	TRUE	TRUE
ENSG00000139618.15	.	BCM	GRCh38.p13	chr13	32332274	32332274	+	T	T	-	Frame_Shift_Del	DEL	ENST00000380152.7	exon10	c.796delT	p.F266Lfs*11	exonic	ENSG00000139618.15	.	frameshift deletion	ENSG00000139618.15:ENST00000380152.7:exon10:c.796delT:p.F266Lfs*11	13q13.1	C3L-02613	.	.	.	.	.	.	.	.	rs886040739	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BRCA2	93	0	39	35	0.472972972972973	TRUE	NA
ENSG00000179630.11	.	BCM	GRCh38.p13	chr13	43881521	43881521	+	C	C	A	Missense_Mutation	SNP	ENST00000325686.7	exon2	c.C536A	p.T179N	exonic	ENSG00000179630.11	.	nonsynonymous SNV	ENSG00000179630.11:ENST00000325686.7:exon2:c.C536A:p.T179N	13q14.11	C3L-02613	.	.	.	.	.	.	.	.	.	4.20	T	T	P	B	N	D	M	T	N	0.261	T	T	T	0.078	0.397	0.560	0.386	T	T	T	T	D	T	1.850	18.110	0.989	D	N	0.300	3.779	0.327	3.880	1.000	0.615	0.588	0.668	0.655	.	5.870	4.080	0.968	1.026	0.599	1.000	0.998	0.994	889	.	.	.	.	LACC1	58	0	42	46	0.522727272727273	TRUE	TRUE
ENSG00000153498.12	.	BCM	GRCh38.p13	chr13	112398066	112398066	+	G	G	C	Missense_Mutation	SNP	ENST00000283550.8	exon3	c.G169C	p.E57Q	exonic	ENSG00000153498.12	.	nonsynonymous SNV	ENSG00000153498.12:ENST00000283550.8:exon3:c.G169C:p.E57Q	13q34	C3L-02613	.	.	.	.	.	.	.	.	.	7.19	D	D	D	D	.	N	L	T	D	0.427	T	T	T	0.131	0.255	0.081	0.300	T	T	T	T	D	T	3.674	25.300	0.993	D	N	0.213	3.360	0.125	2.839	0.074	0.487	0.574	0.574	0.564	.	2.840	2.840	3.083	1.175	0.618	1.000	0.995	0.830	.	.	.	.	ID=COSV52098902;OCCURENCE=1(urinary_tract)	SPACA7	149	0	187	25	0.117924528301887	NA	TRUE
ENSG00000198824.7	.	BCM	GRCh38.p13	chr13	114324977	114324977	+	T	T	G	Missense_Mutation	SNP	ENST00000361283.4	exon3	c.T1135G	p.S379A	exonic	ENSG00000198824.7	.	nonsynonymous SNV	ENSG00000198824.7:ENST00000361283.4:exon3:c.T1135G:p.S379A	13q34	C3L-02613	.	.	.	.	.	.	.	.	.	2.20	T	T	P	B	N	N	M	T	N	0.124	T	T	T	0.063	0.344	0.393	0.462	T	T	T	T	D	T	1.508	15.790	0.995	N	N	0.056	2.717	0.053	2.550	1.000	0.707	0.702	0.702	0.714	.	5.920	4.760	0.280	1.138	0.665	0.082	0.998	0.916	946	.	.	.	.	CHAMP1	206	0	206	206	0.5	TRUE	TRUE
ENSG00000054654.18	.	BCM	GRCh38.p13	chr14	64056086	64056086	+	C	C	G	Missense_Mutation	SNP	ENST00000344113.8	exon49	c.C9887G	p.P3296R	exonic	ENSG00000054654.18	.	nonsynonymous SNV	ENSG00000054654.18:ENST00000344113.8:exon49:c.C9887G:p.P3296R	14q23.2	C3L-02613	.	.	.	.	.	.	.	.	.	1.20	T	D	P	B	N	N	L	T	N	0.295	T	T	T	0.044	0.338	0.263	0.125	T	T	T	T	T	T	0.489	6.393	0.961	N	N	-0.752	0.728	-0.801	0.756	0.509	0.707	0.725	0.659	0.636	.	5.270	2.480	0.188	0.129	0.549	0.000	0.000	0.008	621	.	.	.	.	SYNE2	209	0	418	31	0.0690423162583519	TRUE	TRUE
ENSG00000103932.12	.	BCM	GRCh38.p13	chr15	41531028	41531028	+	G	G	A	Missense_Mutation	SNP	ENST00000304330.9	exon7	c.C938T	p.A313V	exonic	ENSG00000103932.12	.	nonsynonymous SNV	ENSG00000103932.12:ENST00000304330.9:exon7:c.C938T:p.A313V	15q15.1	C3L-02613	.	.	.	.	.	.	.	.	.	2.20	T	T	B	B	N	D	L	T	N	0.062	T	T	T	0.055	0.190	0.309	0.201	T	T	T	T	T	T	1.185	13.510	0.978	D	N	-0.149	2.024	0.026	2.449	1.000	0.707	0.577	0.725	0.662	.	5.360	5.360	1.333	0.209	0.662	0.901	0.028	0.056	201	.	.	.	.	RPAP1	64	0	146	15	0.093167701863354	NA	TRUE
ENSG00000140279.13	.	BCM	GRCh38.p13	chr15	45101813	45101813	+	C	C	A	Missense_Mutation	SNP	ENST00000603300.1	exon21	c.G2831T	p.G944V	exonic	ENSG00000140279.13	.	nonsynonymous SNV	ENSG00000140279.13:ENST00000603300.1:exon21:c.G2831T:p.G944V	15q21.1	C3L-02613	.	.	.	.	.	.	.	.	.	8.20	T	D	B	B	D	D	M	T	N	0.636	T	T	D	0.281	0.492	0.808	0.078	T	T	D	T	T	T	1.393	15.030	0.983	D	D	0.016	2.567	0.046	2.522	0.995	0.497	0.590	0.608	0.542	.	6.080	3.170	3.882	0.129	-0.171	1.000	0.647	0.648	592	.	.	.	.	DUOX2	260	1	466	179	0.277519379844961	TRUE	TRUE
ENSG00000138604.10	.	BCM	GRCh38.p13	chr15	69256205	69256225	+	TGAGAAATATTTTGATGTTTA	TGAGAAATATTTTGATGTTTA	-	In_Frame_Del	DEL	ENST00000261858.7	exon3	c.399_419del	p.E134_Y140del	exonic	ENSG00000138604.10	.	nonframeshift deletion	ENSG00000138604.10:ENST00000261858.7:exon3:c.399_419del:p.E134_Y140del	15q23	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GLCE	340	0	451	225	0.332840236686391	TRUE	TRUE
ENSG00000167971.16	.	BCM	GRCh38.p13	chr16	2187071	2187071	+	C	C	A	Missense_Mutation	SNP	ENST00000343516.8	exon9	c.G837T	p.E279D	exonic	ENSG00000167971.16	.	nonsynonymous SNV	ENSG00000167971.16:ENST00000343516.8:exon9:c.G837T:p.E279D	16p13.3	C3L-02613	.	.	.	.	.	.	.	.	.	4.19	T	T	B	B	.	D	N	T	N	0.231	T	T	T	0.099	0.239	0.563	1.010	T	T	T	T	T	D	1.720	17.160	0.829	D	D	-0.297	1.623	-0.091	2.074	0.983	0.646	0.588	0.645	0.605	.	4.810	4.810	0.623	0.130	-0.176	1.000	0.989	0.809	654	Ankyrin_repeat-containing_domain	.	.	.	CASKIN1	162	2	396	221	0.358184764991896	TRUE	TRUE
ENSG00000085644.14	.	BCM	GRCh38.p13	chr16	3140768	3140768	+	C	C	G	Missense_Mutation	SNP	ENST00000396878.8	exon6	c.C801G	p.D267E	exonic	ENSG00000085644.14	.	nonsynonymous SNV	ENSG00000085644.14:ENST00000396878.8:exon6:c.C801G:p.D267E	16p13.3	C3L-02613	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	.	T	N	0.011	T	T	T	0.018	0.175	0.326	0.156	T	T	T	T	T	T	-0.974	0.009	0.331	N	N	-1.436	0.103	-1.429	0.137	0.009	0.651	0.709	0.645	0.636	.	4.790	-2.900	-2.090	-1.859	-0.491	0.000	0.002	0.001	744	Krueppel-associated_box	.	.	.	ZNF213	52	0	167	94	0.360153256704981	TRUE	TRUE
ENSG00000153446.15	.	BCM	GRCh38.p13	chr16	5044622	5044622	+	T	T	G	Missense_Mutation	SNP	ENST00000315997.5	exon8	c.A1170C	p.R390S	exonic	ENSG00000153446.15	.	nonsynonymous SNV	ENSG00000153446.15:ENST00000315997.5:exon8:c.A1170C:p.R390S	16p13.3	C3L-02613	.	.	.	.	.	.	.	.	.	1.18	D	T	B	B	.	N	N	T	N	0.082	T	T	T	0.022	0.327	0.014	0.007	.	T	T	T	T	T	-0.307	0.301	0.211	N	N	-2.310	0.002	-2.351	0.002	0.999	0.713	0.588	0.609	0.542	.	0.235	-0.470	-2.243	-1.030	-1.316	0.000	0.003	0.060	862	.	.	.	.	C16orf89	102	0	354	114	0.243589743589744	TRUE	TRUE
ENSG00000103479.16	.	BCM	GRCh38.p13	chr16	53465568	53465568	+	G	G	C	Missense_Mutation	SNP	ENST00000262133.11	exon13	c.G1829C	p.R610T	exonic	ENSG00000103479.16	.	nonsynonymous SNV	ENSG00000103479.16:ENST00000262133.11:exon13:c.G1829C:p.R610T	16q12.2	C3L-02613	8.314e-06	9.93e-05	0	0	0	0	0	0	rs369108451	13.20	D	D	D	D	D	D	M	D	N	0.407	D	D	D	0.475	.	0.740	0.371	T	T	T	T	T	D	3.581	25.000	0.933	D	N	0.138	3.041	0.162	3.005	0.999	0.732	0.744	0.744	0.677	.	4.990	3.020	2.046	1.176	0.676	0.989	1.000	0.998	429	.	.	.	.	RBL2	68	0	172	13	0.0702702702702703	TRUE	NA
ENSG00000177508.12	.	BCM	GRCh38.p13	chr16	54285986	54285986	+	G	G	T	Missense_Mutation	SNP	ENST00000329734.4	exon1	c.C65A	p.A22D	exonic	ENSG00000177508.12	.	nonsynonymous SNV	ENSG00000177508.12:ENST00000329734.4:exon1:c.C65A:p.A22D	16q12.2	C3L-02613	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	.	N	N	T	N	0.278	T	T	D	0.038	0.151	0.342	.	D	T	T	T	T	T	1.795	17.700	0.885	D	N	-0.527	1.125	-0.513	1.181	1.000	0.598	0.590	0.608	0.639	.	3.020	2.050	2.049	0.993	0.337	1.000	0.973	0.720	942	.	.	.	.	IRX3	100	0	128	84	0.39622641509434	TRUE	NA
ENSG00000132604.11	.	BCM	GRCh38.p13	chr16	69366976	69366976	+	C	C	G	Missense_Mutation	SNP	ENST00000254942.8	exon7	c.G1171C	p.E391Q	exonic	ENSG00000132604.11	.	nonsynonymous SNV	ENSG00000132604.11:ENST00000254942.8:exon7:c.G1171C:p.E391Q	16q22.1	C3L-02613	.	.	.	.	.	.	.	.	.	4.17	D	T	.	.	N	D	M	.	N	0.193	T	T	T	0.127	.	0.434	.	T	T	T	T	T	T	3.438	24.500	0.993	D	N	0.077	2.795	0.254	3.461	1.000	0.707	0.725	0.725	0.714	.	6.070	6.070	2.386	1.026	0.599	1.000	0.902	0.913	168	.	.	.	.	TERF2	184	0	446	183	0.29093799682035	TRUE	TRUE
ENSG00000157368.10	.	BCM	GRCh38.p13	chr16	70660024	70660040	+	AGGACTGTGAGGTGCCA	AGGACTGTGAGGTGCCA	-	Frame_Shift_Del	DEL	ENST00000429149.6	exon7	c.566_582del	p.D190Sfs*57	exonic	ENSG00000157368.10	.	frameshift deletion	ENSG00000157368.10:ENST00000429149.6:exon7:c.566_582del:p.D190Sfs*57	16q22.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IL34	135	0	172	79	0.314741035856574	TRUE	TRUE
ENSG00000174231.17	.	BCM	GRCh38.p13	chr17	1654016	1654016	+	A	A	C	Missense_Mutation	SNP	ENST00000304992.11	exon38	c.T5988G	p.N1996K	exonic	ENSG00000174231.17	.	nonsynonymous SNV	ENSG00000174231.17:ENST00000304992.11:exon38:c.T5988G:p.N1996K	17p13.3	C3L-02613	.	.	.	.	.	.	.	.	.	12.19	D	T	B	B	D	D	M	D	D	0.926	T	D	.	0.420	0.524	0.819	1.846	D	D	T	T	D	D	1.708	17.080	0.997	D	N	-0.336	1.528	-0.364	1.438	0.972	0.707	0.702	0.698	0.714	.	6.170	-2.620	0.012	-0.043	0.756	0.912	0.949	0.476	631	PRP8_domain_IV_core	.	.	.	PRPF8	358	1	688	111	0.13892365456821	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7673781	7673781	+	C	C	A	Missense_Mutation	SNP	ENST00000269305.8	exon8	c.G839T	p.R280I	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon8:c.G839T:p.R280I	17p13.1	C3L-02613	.	.	.	.	.	.	.	.	rs121912660	19.20	D	D	D	D	D	D	M	D	D	0.935	D	D	D	0.942	0.878	0.984	0.491	T	D	D	D	D	D	4.358	30	0.987	D	D	0.918	11.529	0.845	11.609	1.000	0.722	0.702	0.725	0.735	.	5.130	5.130	7.905	1.022	0.596	0.998	0.860	0.998	432	p53,_DNA-binding_domain	.	.	ID=COSV52687987;OCCURENCE=9(breast),1(large_intestine),1(central_nervous_system),3(ovary),2(haematopoietic_and_lymphoid_tissue),1(soft_tissue),2(prostate),14(lung),5(upper_aerodigestive_tract),1(endometrium)	TP53	483	0	549	457	0.45427435387674	TRUE	TRUE
ENSG00000278540.5	.	BCM	GRCh38.p13	chr17	37258365	37258365	+	C	C	A	Missense_Mutation	SNP	ENST00000614428.4	exon13	c.G1398T	p.M466I	exonic	ENSG00000278540.5	.	nonsynonymous SNV	ENSG00000278540.5:ENST00000614428.4:exon13:c.G1398T:p.M466I	17q12	C3L-02613	.	.	.	.	.	.	.	.	.	15.16	.	D	D	D	D	D	M	.	.	0.741	D	D	D	0.955	0.681	0.897	.	T	D	D	D	D	.	3.692	25.400	0.998	D	D	1.030	14.888	0.971	17.190	1.000	0.707	0.709	0.725	0.714	.	5.830	5.830	7.905	1.026	0.599	1.000	1.000	0.998	689	Biotin_carboxylation_domain;Carbamoyl-phosphate_synthetase_large_subunit-like,_ATP-binding_domain;ATP-grasp_fold	.	.	.	ACACA	196	0	277	99	0.263297872340426	TRUE	TRUE
ENSG00000012048.23	.	BCM	GRCh38.p13	chr17	43094779	43094779	+	T	T	A	Missense_Mutation	SNP	ENST00000357654.9	exon10	c.A752T	p.K251M	exonic	ENSG00000012048.23	.	nonsynonymous SNV	ENSG00000012048.23:ENST00000357654.9:exon10:c.A752T:p.K251M	17q21.31	C3L-02613	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	N	D	M	D	D	0.549	T	T	D	0.519	0.199	0.905	0.521	T	T	D	D	D	D	3.492	24.700	0.994	D	N	0.077	2.797	0.073	2.626	1.000	0.707	0.725	0.725	0.636	.	4.640	4.640	1.531	1.138	0.609	0.987	0.969	0.535	494	.	.	.	.	BRCA1	74	0	130	48	0.269662921348315	TRUE	TRUE
ENSG00000186185.14	.	BCM	GRCh38.p13	chr17	44928050	44928050	+	C	C	A	Missense_Mutation	SNP	ENST00000593135.6	exon13	c.G2252T	p.R751M	exonic	ENSG00000186185.14	.	nonsynonymous SNV	ENSG00000186185.14:ENST00000593135.6:exon13:c.G2252T:p.R751M	17q21.31	C3L-02613	.	.	.	.	.	.	.	.	.	1.16	.	T	B	B	.	N	.	T	.	0.329	T	T	D	0.113	0.258	0.431	0.313	T	T	T	T	T	T	1.652	16.710	0.907	N	N	-0.828	0.614	-0.869	0.663	0.029	0.632	0.577	0.698	0.636	.	4.680	-1.640	0.161	-0.288	0.599	0.000	0.008	0.286	737	.	.	.	.	KIF18B	16	0	38	23	0.377049180327869	TRUE	TRUE
ENSG00000182742.6	.	BCM	GRCh38.p13	chr17	48578000	48578000	+	C	C	A	Missense_Mutation	SNP	ENST00000332503.6	exon1	c.G320T	p.G107V	exonic	ENSG00000182742.6	.	nonsynonymous SNV	ENSG00000182742.6:ENST00000332503.6:exon1:c.G320T:p.G107V	17q21.32	C3L-02613	.	.	.	.	.	.	.	.	.	6.20	T	T	B	B	N	D	M	T	N	0.230	T	T	D	0.049	0.325	0.655	1.025	D	D	T	T	T	T	2.278	21.400	0.928	D	N	-0.623	0.946	-0.568	1.096	1.000	0.598	0.569	0.596	0.492	.	3.380	2.290	0.798	0.943	0.441	0.665	0.991	0.954	654	.	.	.	.	HOXB4	12	0	10	8	0.444444444444444	TRUE	TRUE
ENSG00000154265.16	.	BCM	GRCh38.p13	chr17	69254338	69254356	+	ACTTGCACTCATTCCTTTG	ACTTGCACTCATTCCTTTG	-	Frame_Shift_Del	DEL	ENST00000392676.8	exon32	c.4203_4221del	p.K1402Tfs*2	exonic	ENSG00000154265.16	.	frameshift deletion	ENSG00000154265.16:ENST00000392676.8:exon32:c.4203_4221del:p.K1402Tfs*2	17q24.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ABCA5	97	0	111	61	0.354651162790698	TRUE	TRUE
ENSG00000167880.8	.	BCM	GRCh38.p13	chr17	76018954	76018954	+	G	G	C	Missense_Mutation	SNP	ENST00000301607.8	exon11	c.C1244G	p.P415R	exonic	ENSG00000167880.8	.	nonsynonymous SNV	ENSG00000167880.8:ENST00000301607.8:exon11:c.C1244G:p.P415R	17q25.1	C3L-02613	.	.	.	.	.	.	.	.	.	11.20	D	D	P	B	D	D	M	T	D	0.466	T	T	D	0.267	0.154	0.791	0.477	T	D	T	T	D	T	3.673	25.300	0.998	D	D	0.444	4.630	0.452	4.747	0.998	0.581	0.574	0.576	0.613	.	5.030	5.030	7.425	1.176	0.618	1.000	0.317	0.876	701	SH3_domain	.	.	.	EVPL	33	0	117	52	0.307692307692308	TRUE	TRUE
ENSG00000101557.15	.	BCM	GRCh38.p13	chr18	199215	199215	+	G	G	A	Missense_Mutation	SNP	ENST00000261601.8	exon10	c.G775A	p.E259K	exonic	ENSG00000101557.15	.	nonsynonymous SNV	ENSG00000101557.15:ENST00000261601.8:exon10:c.G775A:p.E259K	18p11.32	C3L-02613	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	N	D	M	T	D	0.777	T	T	D	0.506	0.388	0.418	1.675	T	T	D	T	D	D	4.524	32	0.999	D	D	0.975	13.144	0.936	15.389	1.000	0.707	0.725	0.702	0.742	.	5.730	5.730	9.341	0.218	0.604	1.000	0.998	0.993	558	Ubiquitin_specific_protease_domain;Peptidase_C19,_ubiquitin_carboxyl-terminal_hydrolase	.	.	.	USP14	124	0	245	73	0.229559748427673	TRUE	TRUE
ENSG00000082397.17	.	BCM	GRCh38.p13	chr18	5397109	5397109	+	C	C	G	Missense_Mutation	SNP	ENST00000341928.6	exon18	c.G2790C	p.Q930H	exonic	ENSG00000082397.17	.	nonsynonymous SNV	ENSG00000082397.17:ENST00000341928.6:exon18:c.G2790C:p.Q930H	18p11.31	C3L-02613	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.194	T	T	T	0.048	0.083	0.582	0.149	T	T	T	T	T	T	1.222	13.810	0.874	D	N	-0.351	1.493	-0.280	1.605	0.991	0.706	0.574	0.710	0.714	.	5.870	5.000	1.490	0.130	0.549	0.997	0.012	0.077	766	.	.	.	.	EPB41L3	103	0	121	230	0.655270655270655	TRUE	TRUE
ENSG00000101680.15	.	BCM	GRCh38.p13	chr18	6975011	6975011	+	C	C	T	Missense_Mutation	SNP	ENST00000389658.4	exon46	c.G6515A	p.R2172Q	exonic	ENSG00000101680.15	.	nonsynonymous SNV	ENSG00000101680.15:ENST00000389658.4:exon46:c.G6515A:p.R2172Q	18p11.31	C3L-02613	8.486e-06	0	0	0	0	0	0	6.217e-05	rs746251281	6.20	D	T	B	B	N	D	L	T	D	0.469	T	T	D	0.211	0.556	0.704	0.207	T	T	T	T	D	T	2.762	22.900	0.999	D	N	0.034	2.634	0.142	2.911	0.003	0.719	0.574	0.723	0.564	.	5.380	4.500	1.866	1.018	0.589	0.918	0.710	0.806	872	Laminin_G_domain	.	.	.	LAMA1	144	0	244	106	0.302857142857143	TRUE	NA
ENSG00000134508.12	.	BCM	GRCh38.p13	chr18	23135913	23135913	+	C	C	-	Frame_Shift_Del	DEL	ENST00000256925.11	exon1	c.151delC	p.R53Gfs*80	exonic	ENSG00000134508.12	.	frameshift deletion	ENSG00000134508.12:ENST00000256925.11:exon1:c.151delC:p.R53Gfs*80	18q11.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CABLES1	21	0	33	4	0.108108108108108	NA	TRUE
ENSG00000179981.10	.	BCM	GRCh38.p13	chr18	75287248	75287248	+	C	C	T	Missense_Mutation	SNP	ENST00000580243.2	exon2	c.C1841T	p.S614F	exonic	ENSG00000179981.10	.	nonsynonymous SNV	ENSG00000179981.10:ENST00000580243.2:exon2:c.C1841T:p.S614F	18q22.3	C3L-02613	.	.	.	.	.	.	.	.	.	3.20	D	D	B	B	N	N	M	T	N	0.251	T	T	T	0.040	0.345	0.342	0.608	T	T	T	T	T	T	1.417	15.200	0.266	N	N	-0.886	0.538	-1.039	0.442	0.112	0.563	0.654	0.547	0.636	.	2.020	1.130	1.525	0.952	0.599	0.005	0.003	0.034	1000	.	.	.	.	TSHZ1	158	0	399	122	0.234165067178503	TRUE	TRUE
ENSG00000189001.11	.	BCM	GRCh38.p13	chr19	35527711	35527711	+	C	C	A	Nonsense_Mutation	SNP	ENST00000452271.7	exon1	c.G571T	p.G191X	exonic	ENSG00000189001.11	.	stopgain	ENSG00000189001.11:ENST00000452271.7:exon1:c.G571T:p.G191X	19q13.12	C3L-02613	.	.	.	.	.	.	.	.	.	3.5	.	.	.	.	.	D	.	.	.	0.221	.	.	.	.	.	.	.	.	.	D	D	.	.	4.947	33	0.988	N	N	0.429	4.529	0.085	2.674	0.939	0.549	0.627	0.590	0.542	.	4.100	4.100	1.410	0.959	0.594	0.003	0.004	0.003	835	.	.	.	.	SBSN	546	1	1059	370	0.258922323303009	TRUE	TRUE
ENSG00000105675.9	.	BCM	GRCh38.p13	chr19	35560485	35560485	+	C	C	T	Missense_Mutation	SNP	ENST00000262623.4	exon6	c.G665A	p.C222Y	exonic	ENSG00000105675.9	.	nonsynonymous SNV	ENSG00000105675.9:ENST00000262623.4:exon6:c.G665A:p.C222Y	19q13.12	C3L-02613	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	L	D	D	0.856	D	D	D	0.874	0.578	0.994	1.796	D	D	D	D	D	D	3.944	26.600	0.997	D	D	0.740	7.716	0.655	6.994	1.000	0.549	0.588	0.590	0.542	.	4.160	4.160	6.117	1.025	0.547	1.000	1.000	0.997	814	.	.	.	.	ATP4A	239	0	619	239	0.278554778554779	TRUE	TRUE
ENSG00000196235.14	.	BCM	GRCh38.p13	chr19	39458834	39458836	+	TGT	TGT	-	In_Frame_Del	DEL	ENST00000432763.7	exon6	c.336_338del	p.V114del	exonic	ENSG00000196235.14	.	nonframeshift deletion	ENSG00000196235.14:ENST00000432763.7:exon6:c.336_338del:p.V114del	19q13.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SUPT5H	65	0	111	44	0.283870967741935	TRUE	TRUE
ENSG00000224420.3	.	BCM	GRCh38.p13	chr19	49690239	49690239	+	C	C	G	Missense_Mutation	SNP	ENST00000420022.3	exon2	c.C208G	p.R70G	exonic	ENSG00000224420.3	.	nonsynonymous SNV	ENSG00000224420.3:ENST00000420022.3:exon2:c.C208G:p.R70G	19q13.33	C3L-02613	.	.	.	.	.	.	.	.	.	3.18	D	D	P	B	.	N	N	.	D	0.148	T	T	T	0.034	0.284	0.076	1.256	T	T	T	T	T	T	0.779	9.190	0.928	N	N	-0.889	0.534	-1.058	0.421	1.000	0.658	0.707	0.240	0.619	.	2.140	-0.566	-2.753	0.811	0.524	0.000	0.009	0.006	814	.	.	.	.	ADM5	222	0	498	179	0.264401772525849	TRUE	TRUE
ENSG00000105501.12	.	BCM	GRCh38.p13	chr19	51627924	51627924	+	G	G	A	Nonsense_Mutation	SNP	ENST00000429354.3	exon5	c.C907T	p.R303X	exonic	ENSG00000105501.12;ENSG00000268500.5	.	stopgain	ENSG00000268500.5:ENST00000429354.3:exon5:c.C907T:p.R303X,ENSG00000105501.12:ENST00000534261.3:exon6:c.C907T:p.R303X	19q13.41	C3L-02613	0.0008	0.0002	0.0010	0	0.0032	0.0009	0.0033	0.0001	rs149130627	2.6	.	.	.	.	N	A	.	.	.	0.415	.	.	.	.	.	.	.	.	.	T	D	.	.	4.961	33	0.981	N	N	-0.384	1.418	-0.782	0.783	0.999	0.615	0.634	0.624	0.564	.	3.400	-1.480	-0.550	0.071	-0.119	0.000	0.000	0.000	982	Immunoglobulin_subtype_2;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	SIGLEC5	79	0	126	46	0.267441860465116	TRUE	NA
ENSG00000232388.5	.	BCM	GRCh38.p13	chr20	18569380	18569380	+	C	C	T	Missense_Mutation	SNP	ENST00000411646.2	exon2	c.C263T	p.T88I	exonic	ENSG00000232388.5	.	nonsynonymous SNV	ENSG00000232388.5:ENST00000411646.2:exon2:c.C263T:p.T88I	20p11.23	C3L-02613	.	.	.	.	.	.	.	.	.	2.7	.	D	.	.	.	N	.	.	.	0.147	.	.	.	.	.	0.350	.	.	T	T	T	.	T	2.860	23.100	0.659	D	.	.	.	.	.	0.908	0.732	0.725	0.710	0.728	0.766	5.320	4.340	0.924	-0.246	0.596	1.000	0.077	0.372	618	.	.	.	.	SMIM26	256	0	470	169	0.264475743348983	TRUE	TRUE
ENSG00000198547.9	.	BCM	GRCh38.p13	chr20	32651150	32651150	+	C	C	A	Translation_Start_Site	SNP	ENST00000608990.6	exon3	c.G3T	p.M1?	exonic	ENSG00000198547.9	.	startloss	ENSG00000198547.9:ENST00000608990.6:exon3:c.G3T:p.M1?	20q11.21	C3L-02613	.	.	.	.	.	.	.	.	.	0.2	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	.	.	.	.	0.820	9.597	0.645	N	.	.	.	.	.	0.997	0.054	0.061	0.045	0.057	0.084	0.722	-0.879	0.305	0.377	0.333	0.029	0.149	0.089	293	.	.	.	.	C20orf203	23	0	111	11	0.0901639344262295	TRUE	NA
ENSG00000185513.16	.	BCM	GRCh38.p13	chr20	43534013	43534013	+	C	C	T	Missense_Mutation	SNP	ENST00000427442.8	exon14	c.C1453T	p.P485S	exonic	ENSG00000185513.16;ENSG00000288000.1	.	nonsynonymous SNV	ENSG00000185513.16:ENST00000427442.8:exon14:c.C1453T:p.P485S	20q13.12	C3L-02613	.	.	.	.	.	.	.	.	.	9.20	D	D	B	B	D	D	L	T	D	0.285	T	T	T	0.137	0.401	0.259	0.233	T	T	T	T	D	D	2.904	23.200	0.999	D	D	0.291	3.733	0.436	4.628	1.000	0.615	0.634	0.659	0.655	.	5.920	5.920	4.710	1.026	0.599	1.000	1.000	0.997	649	.	.	.	.	L3MBTL1	136	0	278	135	0.326876513317191	TRUE	TRUE
ENSG00000154645.14	.	BCM	GRCh38.p13	chr21	18262833	18262833	+	C	C	A	Missense_Mutation	SNP	ENST00000299295.7	exon5	c.C677A	p.P226H	exonic	ENSG00000154645.14	.	nonsynonymous SNV	ENSG00000154645.14:ENST00000299295.7:exon5:c.C677A:p.P226H	21q21.1	C3L-02613	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.905	T	T	D	0.353	0.457	0.270	0.415	D	T	D	T	D	D	3.536	24.800	0.996	D	D	0.729	7.538	0.679	7.382	1.000	0.554	0.588	0.574	0.613	.	5.390	5.390	7.070	1.026	0.599	1.000	0.572	0.909	984	.	.	.	.	CHODL	172	0	248	77	0.236923076923077	TRUE	TRUE
ENSG00000211658.2	.	BCM	GRCh38.p13	chr22	22668615	22668615	+	-	NA	A	Nonsense_Mutation	SNP	ENST00000390304.2	exon2	c.149dupA	p.Y50*	exonic	ENSG00000211658.2	.	stopgain	ENSG00000211658.2:ENST00000390304.2:exon2:c.149dupA:p.Y50*	22q11.22	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IGLV3-27	NA	NA	NA	NA	NA	NA	NA
ENSG00000056487.16	.	BCM	GRCh38.p13	chr22	44891311	44891311	+	G	G	T	Missense_Mutation	SNP	ENST00000313237.10	exon8	c.C1010A	p.A337E	exonic	ENSG00000056487.16	.	nonsynonymous SNV	ENSG00000056487.16:ENST00000313237.10:exon8:c.C1010A:p.A337E	22q13.31	C3L-02613	.	.	.	.	.	.	.	.	.	7.20	D	T	D	P	N	N	L	T	D	0.441	T	T	D	0.092	0.382	0.134	0.548	T	T	T	T	D	D	3.344	24.200	0.992	D	N	0.324	3.905	0.321	3.840	1.000	0.635	0.547	0.644	0.568	.	4.910	4.910	4.308	1.176	0.676	1.000	0.491	0.066	982	.	.	.	.	PHF21B	173	0	438	30	0.0641025641025641	TRUE	TRUE
ENSG00000169306.10	.	BCM	GRCh38.p13	chrX	29917596	29917596	+	G	G	A	Missense_Mutation	SNP	ENST00000378993.6	exon7	c.G911A	p.R304K	exonic	ENSG00000169306.10	.	nonsynonymous SNV	ENSG00000169306.10:ENST00000378993.6:exon7:c.G911A:p.R304K	Xp21.2	C3L-02613	.	.	.	.	.	.	.	.	.	6.19	T	T	B	B	D	D	N	T	N	0.086	T	T	D	0.108	0.598	0.725	0.860	T	T	T	T	D	D	3.451	24.600	0.983	D	.	.	.	.	.	1.000	.	.	.	.	.	5.780	5.780	7.288	1.175	0.676	1.000	0.998	0.899	821	Immunoglobulin_subtype_2;Immunoglobulin;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	IL1RAPL1	249	0	352	133	0.274226804123711	NA	TRUE
ENSG00000184675.11	.	BCM	GRCh38.p13	chrX	64190851	64190861	+	AGCGATGTCAA	AGCGATGTCAA	-	Nonsense_Mutation	DEL	ENST00000374869.8	exon2	c.2426_2436del	p.F809*	exonic	ENSG00000184675.11	.	stopgain	ENSG00000184675.11:ENST00000374869.8:exon2:c.2426_2436del:p.F809*	Xq11.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AMER1	242	0	501	149	0.229230769230769	TRUE	TRUE
ENSG00000147140.16	.	BCM	GRCh38.p13	chrX	71294339	71294339	+	A	A	G	Missense_Mutation	SNP	ENST00000276079.13	exon5	c.A461G	p.N154S	exonic	ENSG00000147140.16	.	nonsynonymous SNV	ENSG00000147140.16:ENST00000276079.13:exon5:c.A461G:p.N154S	Xq13.1	C3L-02613	.	.	.	.	.	.	.	.	.	9.19	D	T	P	P	D	D	M	T	D	0.834	T	T	D	0.389	0.651	0.896	2.287	T	T	T	T	D	D	3.608	25.100	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	4.660	4.660	9.203	1.197	0.747	1.000	1.000	0.996	526	RNA_recognition_motif_domain;p54nrb,_RNA_recognition_motif_2	.	.	.	NONO	378	1	952	79	0.0766246362754607	NA	TRUE
ENSG00000102385.12	.	BCM	GRCh38.p13	chrX	101241918	101241918	+	G	G	T	Missense_Mutation	SNP	ENST00000395209.7	exon7	c.G810T	p.E270D	exonic	ENSG00000102385.12	.	nonsynonymous SNV	ENSG00000102385.12:ENST00000395209.7:exon7:c.G810T:p.E270D	Xq22.1	C3L-02613	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	N	D	N	T	N	0.157	T	T	D	0.135	0.457	0.355	0.367	T	T	T	T	T	T	0.564	7.159	0.303	D	.	.	.	.	.	0.263	.	.	.	.	.	5.290	-3.150	0.193	-0.140	0.676	0.975	0.997	0.998	124	.	.	.	.	DRP2	118	0	142	107	0.429718875502008	TRUE	TRUE
ENSG00000134594.5	.	BCM	GRCh38.p13	chrX	130184429	130184429	+	T	T	A	Missense_Mutation	SNP	ENST00000257017.5	exon2	c.T403A	p.C135S	exonic	ENSG00000134594.5	.	nonsynonymous SNV	ENSG00000134594.5:ENST00000257017.5:exon2:c.T403A:p.C135S	Xq26.1	C3L-02613	.	.	.	.	.	.	.	.	.	15.19	D	D	D	D	D	D	L	T	D	0.748	T	T	D	0.829	0.718	0.977	2.533	D	D	D	D	D	D	3.781	25.700	0.994	D	.	.	.	.	.	1.000	.	.	.	.	.	4.720	4.720	8.017	1.137	0.665	1.000	1.000	0.999	519	Small_GTP-binding_protein_domain	.	.	.	RAB33A	247	1	275	225	0.45	TRUE	TRUE
ENSG00000171806.12	.	BCM	GRCh38.p13	chr1	169793300	169793300	+	C	C	T	Silent	SNP	ENST00000310392.5	exon2	c.G396A	p.V132V	exonic	ENSG00000171806.12	.	synonymous SNV	ENSG00000171806.12:ENST00000310392.5:exon2:c.G396A:p.V132V	1q24.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	METTL18	124	0	257	109	0.297814207650273	TRUE	TRUE
ENSG00000158089.15	.	BCM	GRCh38.p13	chr2	30958452	30958452	+	G	G	A	Silent	SNP	ENST00000349752.10	exon4	c.C411T	p.R137R	exonic	ENSG00000158089.15	.	synonymous SNV	ENSG00000158089.15:ENST00000349752.10:exon4:c.C411T:p.R137R	2p23.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GALNT14	134	0	251	75	0.230061349693252	TRUE	TRUE
ENSG00000162881.6	.	BCM	GRCh38.p13	chr2	42762983	42762983	+	C	C	T	Silent	SNP	ENST00000378661.3	exon1	c.G1197A	p.R399R	exonic	ENSG00000162881.6	.	synonymous SNV	ENSG00000162881.6:ENST00000378661.3:exon1:c.G1197A:p.R399R	2p21	C3L-02613	8.277e-06	0	0	0	0	1.509e-05	0	0	rs142162926	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OXER1	181	0	464	220	0.321637426900585	TRUE	NA
ENSG00000138399.18	.	BCM	GRCh38.p13	chr2	169571799	169571799	+	C	C	T	Silent	SNP	ENST00000453153.7	exon2	c.G231A	p.K77K	exonic	ENSG00000138399.18	.	synonymous SNV	ENSG00000138399.18:ENST00000453153.7:exon2:c.G231A:p.K77K	2q31.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV70006980;OCCURENCE=1(large_intestine)	FASTKD1	129	0	258	65	0.201238390092879	TRUE	TRUE
ENSG00000163946.13	.	BCM	GRCh38.p13	chr3	56646562	56646562	+	G	G	C	Silent	SNP	ENST00000355628.9	exon14	c.C2175G	p.A725A	exonic	ENSG00000163946.13	.	synonymous SNV	ENSG00000163946.13:ENST00000355628.9:exon14:c.C2175G:p.A725A	3p14.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TASOR	97	0	80	48	0.375	TRUE	TRUE
ENSG00000174948.6	.	BCM	GRCh38.p13	chr3	154337894	154337894	+	C	C	A	Silent	SNP	ENST00000389740.3	exon4	c.G2001T	p.G667G	exonic	ENSG00000174948.6	.	synonymous SNV	ENSG00000174948.6:ENST00000389740.3:exon4:c.G2001T:p.G667G	3q25.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67668118;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	GPR149	73	0	179	49	0.214912280701754	TRUE	TRUE
ENSG00000180611.7	.	BCM	GRCh38.p13	chr3	192798650	192798650	+	G	G	T	Silent	SNP	ENST00000392452.3	exon2	c.C1212A	p.R404R	exonic	ENSG00000180611.7	.	synonymous SNV	ENSG00000180611.7:ENST00000392452.3:exon2:c.C1212A:p.R404R	3q29	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MB21D2	146	0	758	167	0.180540540540541	TRUE	TRUE
ENSG00000163960.12	.	BCM	GRCh38.p13	chr3	196356700	196356700	+	T	T	G	Silent	SNP	ENST00000296328.9	exon11	c.A1455C	p.V485V	exonic	ENSG00000163960.12	.	synonymous SNV	ENSG00000163960.12:ENST00000296328.9:exon11:c.A1455C:p.V485V	3q29	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBXN7	100	0	496	63	0.112701252236136	TRUE	TRUE
ENSG00000138823.13	.	BCM	GRCh38.p13	chr4	99591351	99591351	+	G	G	A	Silent	SNP	ENST00000457717.5	exon6	c.G618A	p.Q206Q	exonic	ENSG00000138823.13	.	synonymous SNV	ENSG00000138823.13:ENST00000457717.5:exon6:c.G618A:p.Q206Q	4q23	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MTTP	212	0	318	145	0.31317494600432	TRUE	NA
ENSG00000113749.7	.	BCM	GRCh38.p13	chr5	175683572	175683572	+	C	C	T	Silent	SNP	ENST00000231683.3	exon1	c.C339T	p.S113S	exonic	ENSG00000113749.7	.	synonymous SNV	ENSG00000113749.7:ENST00000231683.3:exon1:c.C339T:p.S113S	5q35.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HRH2	267	0	790	251	0.241114313160423	TRUE	TRUE
ENSG00000178187.7	.	BCM	GRCh38.p13	chr5	178946364	178946364	+	G	G	A	Silent	SNP	ENST00000320129.7	exon3	c.G39A	p.S13S	exonic	ENSG00000178187.7	.	synonymous SNV	ENSG00000178187.7:ENST00000320129.7:exon3:c.G39A:p.S13S	5q35.3	C3L-02613	1.647e-05	0	0	0	0	2.997e-05	0	0	rs770644793	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100194756;OCCURENCE=1(central_nervous_system)	ZNF454	156	0	498	147	0.227906976744186	TRUE	NA
ENSG00000197226.12	.	BCM	GRCh38.p13	chr5	179870430	179870430	+	G	G	A	Silent	SNP	ENST00000356834.7	exon16	c.C2550T	p.S850S	exonic	ENSG00000197226.12	.	synonymous SNV	ENSG00000197226.12:ENST00000356834.7:exon16:c.C2550T:p.S850S	5q35.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TBC1D9B	157	0	326	308	0.485804416403785	TRUE	TRUE
ENSG00000261272.1	.	BCM	GRCh38.p13	chr6	31025599	31025599	+	T	T	G	Silent	SNP	ENST00000561890.1	exon2	c.T168G	p.T56T	exonic	ENSG00000261272.1	.	synonymous SNV	ENSG00000261272.1:ENST00000561890.1:exon2:c.T168G:p.T56T	6p21.33	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC22	139	0	346	62	0.151960784313725	TRUE	TRUE
ENSG00000173041.12	.	BCM	GRCh38.p13	chr7	64522184	64522184	+	T	T	A	Silent	SNP	ENST00000309683.11	exon4	c.A570T	p.S190S	exonic	ENSG00000173041.12	.	synonymous SNV	ENSG00000173041.12:ENST00000309683.11:exon4:c.A570T:p.S190S	7q11.21	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF680	107	0	127	51	0.286516853932584	TRUE	TRUE
ENSG00000148082.10	.	BCM	GRCh38.p13	chr9	89042123	89042123	+	T	T	A	Silent	SNP	ENST00000375835.9	exon10	c.A1263T	p.A421A	exonic	ENSG00000148082.10	.	synonymous SNV	ENSG00000148082.10:ENST00000375835.9:exon10:c.A1263T:p.A421A	9q22.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SHC3	83	0	130	53	0.289617486338798	TRUE	TRUE
ENSG00000169071.15	.	BCM	GRCh38.p13	chr9	91724145	91724145	+	G	G	A	Silent	SNP	ENST00000375708.4	exon9	c.C2349T	p.N783N	exonic	ENSG00000169071.15	.	synonymous SNV	ENSG00000169071.15:ENST00000375708.4:exon9:c.C2349T:p.N783N	9q22.31	C3L-02613	4.132e-05	9.701e-05	0	0	0	3.008e-05	0	0.0001	rs761291207	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100995391;OCCURENCE=1(large_intestine),1(stomach)	ROR2	132	0	263	138	0.344139650872818	TRUE	NA
ENSG00000165124.18	.	BCM	GRCh38.p13	chr9	110472286	110472286	+	G	G	A	Silent	SNP	ENST00000374469.6	exon15	c.C2637T	p.Y879Y	exonic	ENSG00000165124.18	.	synonymous SNV	ENSG00000165124.18:ENST00000374469.6:exon15:c.C2637T:p.Y879Y	9q31.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SVEP1	107	0	163	71	0.303418803418803	TRUE	TRUE
ENSG00000197859.11	.	BCM	GRCh38.p13	chr9	133554545	133554545	+	A	A	C	Silent	SNP	ENST00000651351.2	exon10	c.A1128C	p.S376S	exonic	ENSG00000197859.11	.	synonymous SNV	ENSG00000197859.11:ENST00000651351.2:exon10:c.A1128C:p.S376S	9q34.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADAMTSL2	161	0	465	201	0.301801801801802	TRUE	TRUE
ENSG00000181371.4	.	BCM	GRCh38.p13	chr11	56490612	56490612	+	G	G	T	Silent	SNP	ENST00000327216.4	exon1	c.C759A	p.T253T	exonic	ENSG00000181371.4	.	synonymous SNV	ENSG00000181371.4:ENST00000327216.4:exon1:c.C759A:p.T253T	11q12.1	C3L-02613	8.295e-06	0	0	0.0001	0	0	0	0	rs777315851	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR5M8	138	0	168	86	0.338582677165354	TRUE	NA
ENSG00000213593.10	.	BCM	GRCh38.p13	chr11	57739257	57739257	+	T	T	G	Silent	SNP	ENST00000278422.9	exon7	c.T741G	p.S247S	exonic	ENSG00000213593.10	.	synonymous SNV	ENSG00000213593.10:ENST00000278422.9:exon7:c.T741G:p.S247S	11q12.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMX2	144	0	282	98	0.257894736842105	TRUE	TRUE
ENSG00000186513.3	.	BCM	GRCh38.p13	chr11	58190712	58190712	+	G	G	A	Silent	SNP	ENST00000641291.1	exon2	c.G222A	p.S74S	exonic	ENSG00000186513.3	.	synonymous SNV	ENSG00000186513.3:ENST00000641291.1:exon2:c.G222A:p.S74S	11q12.1	C3L-02613	0	0	0	0	0	0	0	0	rs760143408	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61113093;OCCURENCE=1(stomach),1(thyroid)	OR9Q2	163	0	380	125	0.247524752475248	TRUE	TRUE
ENSG00000169884.14	.	BCM	GRCh38.p13	chr12	48970129	48970129	+	G	G	A	Silent	SNP	ENST00000301061.9	exon3	c.C297T	p.G99G	exonic	ENSG00000169884.14	.	synonymous SNV	ENSG00000169884.14:ENST00000301061.9:exon3:c.C297T:p.G99G	12q13.12	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	WNT10B	79	0	118	132	0.528	TRUE	TRUE
ENSG00000187857.4	.	BCM	GRCh38.p13	chr12	55365767	55365767	+	C	C	A	Silent	SNP	ENST00000641576.1	exon3	c.C657A	p.I219I	exonic	ENSG00000187857.4	.	synonymous SNV	ENSG00000187857.4:ENST00000641576.1:exon3:c.C657A:p.I219I	12q13.2	C3L-02613	8.243e-06	0	0	0	0	1.499e-05	0	0	rs375544134	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100595436;OCCURENCE=1(endometrium)	OR6C75	228	0	218	207	0.487058823529412	TRUE	NA
ENSG00000111087.10	.	BCM	GRCh38.p13	chr12	57465832	57465832	+	A	A	G	Silent	SNP	ENST00000228682.7	exon7	c.A669G	p.R223R	exonic	ENSG00000111087.10	.	synonymous SNV	ENSG00000111087.10:ENST00000228682.7:exon7:c.A669G:p.R223R	12q13.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GLI1	172	0	180	162	0.473684210526316	TRUE	TRUE
ENSG00000090975.12	.	BCM	GRCh38.p13	chr12	122987391	122987391	+	C	C	G	Silent	SNP	ENST00000320201.8	exon22	c.G3303C	p.L1101L	exonic	ENSG00000090975.12	.	synonymous SNV	ENSG00000090975.12:ENST00000320201.8:exon22:c.G3303C:p.L1101L	12q24.31	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PITPNM2	164	0	196	171	0.465940054495913	TRUE	TRUE
ENSG00000074803.20	.	BCM	GRCh38.p13	chr15	48291829	48291829	+	C	C	T	Silent	SNP	ENST00000380993.8	exon24	c.C2925T	p.I975I	exonic	ENSG00000074803.20	.	synonymous SNV	ENSG00000074803.20:ENST00000380993.8:exon24:c.C2925T:p.I975I	15q21.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC12A1	143	0	241	68	0.220064724919094	TRUE	TRUE
ENSG00000153443.13	.	BCM	GRCh38.p13	chr16	4609740	4609740	+	G	G	A	Silent	SNP	ENST00000283474.12	exon3	c.C427T	p.L143L	exonic	ENSG00000153443.13	.	synonymous SNV	ENSG00000153443.13:ENST00000283474.12:exon3:c.C427T:p.L143L	16p13.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	UBALD1	10	0	25	9	0.264705882352941	TRUE	TRUE
ENSG00000140623.14	.	BCM	GRCh38.p13	chr16	4777962	4777962	+	G	G	A	Silent	SNP	ENST00000268231.13	exon10	c.C912T	p.N304N	exonic	ENSG00000140623.14	.	synonymous SNV	ENSG00000140623.14:ENST00000268231.13:exon10:c.C912T:p.N304N	16p13.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SEPTIN12	170	0	382	174	0.31294964028777	TRUE	TRUE
ENSG00000184857.8	.	BCM	GRCh38.p13	chr16	8796243	8796243	+	C	C	G	Silent	SNP	ENST00000333050.7	exon2	c.G351C	p.L117L	exonic	ENSG00000184857.8	.	synonymous SNV	ENSG00000184857.8:ENST00000333050.7:exon2:c.G351C:p.L117L	16p13.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM186	214	0	452	173	0.2768	TRUE	TRUE
ENSG00000168447.11	.	BCM	GRCh38.p13	chr16	23380780	23380780	+	C	C	T	Silent	SNP	ENST00000343070.7	exon13	c.C1902T	p.D634D	exonic	ENSG00000168447.11	.	synonymous SNV	ENSG00000168447.11:ENST00000343070.7:exon13:c.C1902T:p.D634D	16p12.2	C3L-02613	.	.	.	.	.	.	.	.	rs995687895	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SCNN1B	168	0	432	56	0.114754098360656	TRUE	NA
ENSG00000167889.12	.	BCM	GRCh38.p13	chr17	76926660	76926660	+	C	C	G	Silent	SNP	ENST00000569840.6	exon10	c.C1221G	p.A407A	exonic	ENSG00000167889.12	.	synonymous SNV	ENSG00000167889.12:ENST00000569840.6:exon10:c.C1221G:p.A407A	17q25.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MGAT5B	147	0	372	103	0.216842105263158	TRUE	TRUE
ENSG00000186818.12	.	BCM	GRCh38.p13	chr19	54664220	54664220	+	G	G	A	Silent	SNP	ENST00000391733.7	exon4	c.G390A	p.P130P	exonic	ENSG00000186818.12	.	synonymous SNV	ENSG00000186818.12:ENST00000391733.7:exon4:c.G390A:p.P130P	19q13.42	C3L-02613	8.266e-06	0	0	0	0	1.502e-05	0	0	rs372420039	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54406424;OCCURENCE=1(large_intestine)	LILRB4	128	0	229	187	0.449519230769231	TRUE	TRUE
ENSG00000101161.8	.	BCM	GRCh38.p13	chr20	63999098	63999098	+	G	G	A	Silent	SNP	ENST00000266079.5	exon7	c.G825A	p.T275T	exonic	ENSG00000101161.8	.	synonymous SNV	ENSG00000101161.8:ENST00000266079.5:exon7:c.G825A:p.T275T	20q13.33	C3L-02613	8.447e-06	0.0001	0	0	0	0	0	0	rs201487454	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PRPF6	226	1	447	203	0.312307692307692	TRUE	NA
ENSG00000169548.3	.	BCM	GRCh38.p13	chr22	22515073	22515073	+	T	T	A	Silent	SNP	ENST00000302097.3	exon2	c.A558T	p.G186G	exonic	ENSG00000169548.3	.	synonymous SNV	ENSG00000169548.3:ENST00000302097.3:exon2:c.A558T:p.G186G	22q11.22	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF280A	177	0	428	40	0.0854700854700855	TRUE	TRUE
ENSG00000181798.3	.	BCM	GRCh38.p13	chr2	231509270	231509270	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000181798.3	.	.	.	2q37.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	LINC00471	191	0	419	186	0.307438016528926	TRUE	NA
ENSG00000245317.2	.	BCM	GRCh38.p13	chr5	179860595	179860595	+	A	A	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000245317.2	.	.	.	5q35.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC008393.1	220	0	724	70	0.0881612090680101	TRUE	NA
ENSG00000124721.18	.	BCM	GRCh38.p13	chr6	38722836	38722836	+	C	C	G	5'Flank	SNP	NA	NA	NA	NA	upstream	ENSG00000124721.18	dist=286	.	.	6p21.2	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	DNAH8	63	0	205	54	0.208494208494208	TRUE	TRUE
ENSG00000122852.15	.	BCM	GRCh38.p13	chr10	79611631	79611631	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000122852.15	.	.	.	10q22.3	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SFTPA1	87	0	100	80	0.444444444444444	NA	TRUE
ENSG00000177359.20	.	BCM	GRCh38.p13	chr12	31136138	31136138	+	A	A	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000177359.20	.	.	.	12p11.21	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC024940.2	230	0	289	136	0.32	NA	TRUE
ENSG00000258365.1	.	BCM	GRCh38.p13	chr12	94279766	94279779	+	CAGCCAGGTTGTTC	CAGCCAGGTTGTTC	-	RNA	DEL	NA	NA	NA	NA	ncRNA_exonic	ENSG00000258365.1	.	.	.	12q22	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC073655.2	175	0	181	65	0.264227642276423	TRUE	NA
ENSG00000073910.22	.	BCM	GRCh38.p13	chr13	32287873	32287873	+	G	G	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000073910.22	.	.	.	13q13.1	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FRY	60	0	63	39	0.382352941176471	TRUE	NA
ENSG00000287385.1	.	BCM	GRCh38.p13	chr14	68611157	68611157	+	G	G	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000287385.1	.	.	.	14q24.1	C3L-02613	.	.	.	.	.	.	.	.	.	0.17	T	T	B	B	.	N	.	T	N	0.098	T	T	T	0.053	0.315	0.085	.	.	T	T	T	T	T	0.634	7.837	0.216	N	N	-0.939	0.473	-1.051	0.428	1.000	0.554	0.588	0.574	0.568	.	2.870	-0.439	1.121	1.160	0.655	0.009	0.005	0.003	511	.	.	.	.	AL121820.3	329	1	882	54	0.0576923076923077	TRUE	TRUE
ENSG00000214941.8	.	BCM	GRCh38.p13	chr17	15999627	15999627	+	G	G	A	5'UTR	SNP	NA	NA	NA	NA	UTR5	ENSG00000214941.8	ENST00000399277.6:c.-33C>T	.	.	17p12	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZSWIM7	283	0	366	336	0.478632478632479	TRUE	NA
ENSG00000184922.14	.	BCM	GRCh38.p13	chr17	45246355	45246355	+	C	C	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000184922.14	.	.	.	17q21.31	C3L-02613	.	.	.	.	.	.	.	.	.	1.9	.	D	.	.	.	N	.	T	.	.	.	.	.	.	.	0.506	.	.	T	T	T	.	T	0.235	3.531	0.649	N	N	.	.	.	.	1.000	0.722	0.699	0.615	0.639	.	3.300	0.844	0.727	0.053	-0.319	0.000	0.001	0.002	463	.	.	.	.	FMNL1	162	0	447	28	0.0589473684210526	TRUE	TRUE
ENSG00000131943.18	.	BCM	GRCh38.p13	chr19	29705352	29705352	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000131943.18	.	.	.	19q12	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C19orf12	105	0	118	49	0.293413173652695	TRUE	NA
ENSG00000176029.14	.	BCM	GRCh38.p13	chr11	8925852	8925853	+	GC	GC	AT	Unknown	MNP	ENST00000326053.10	exon5	c.814_815delinsAT	p.A272I	exonic	ENSG00000176029.14	.	nonframeshift substitution	ENSG00000176029.14:ENST00000326053.10:exon5:c.814_815delinsAT:p.A272I	11p15.4	C3L-02613	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C11orf16	241	0	501	168	0.251121076233184	TRUE	TRUE
ENSG00000143669.14	.	BCM	GRCh38.p13	chr1	235788702	235788702	+	G	G	A	Missense_Mutation	SNP	ENST00000389793.7	exon13	c.C4687T	p.R1563C	exonic	ENSG00000143669.14	.	nonsynonymous SNV	ENSG00000143669.14:ENST00000389793.7:exon13:c.C4687T:p.R1563C	1q42.3	C3N-01012	8.439e-06	0	0	0	0	1.539e-05	0	0	rs749045467	16.20	D	D	D	P	N	D	M	T	D	0.932	D	D	D	0.709	0.749	0.821	.	T	D	D	D	D	D	5.279	33	0.999	D	D	0.691	6.994	0.693	7.619	0.988	0.615	0.588	0.574	0.655	.	5.620	5.620	5.114	1.176	0.676	1.000	1.000	0.997	846	.	.	.	ID=COSV67710457;OCCURENCE=1(large_intestine)	LYST	258	1	480	33	0.064327485380117	TRUE	TRUE
ENSG00000178568.15	.	BCM	GRCh38.p13	chr2	212124891	212124891	+	G	G	A	Missense_Mutation	SNP	ENST00000342788.9	exon2	c.C95T	p.T32M	exonic	ENSG00000178568.15	.	nonsynonymous SNV	ENSG00000178568.15:ENST00000342788.9:exon2:c.C95T:p.T32M	2q34	C3N-01012	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	T	D	0.769	D	D	D	0.795	0.684	0.857	0.918	D	D	D	D	D	D	3.849	26.100	0.999	D	D	0.856	9.979	0.846	11.617	1.000	0.487	0.574	0.547	0.632	.	5.280	5.280	9.938	1.176	0.676	1.000	1.000	0.997	801	.	.	.	ID=COSV53593488;OCCURENCE=1(large_intestine)	ERBB4	304	0	609	35	0.0543478260869565	TRUE	NA
ENSG00000163359.16	.	BCM	GRCh38.p13	chr2	237394887	237394887	+	G	G	A	Missense_Mutation	SNP	ENST00000295550.9	exon3	c.C409T	p.R137W	exonic	ENSG00000163359.16	.	nonsynonymous SNV	ENSG00000163359.16:ENST00000295550.9:exon3:c.C409T:p.R137W	2q37.3	C3N-01012	2.474e-05	0.0002	0	0	0	1.501e-05	0	0	rs143819673	18.20	D	D	D	D	U	D	H	D	D	0.795	D	D	D	0.896	.	0.945	0.660	T	D	D	D	D	D	4.378	31	0.975	D	D	0.699	7.103	0.613	6.384	1.000	0.487	0.590	0.574	0.479	.	4.930	3.980	3.349	1.176	0.676	1.000	0.998	0.996	937	von_Willebrand_factor,_type_A	.	.	.	COL6A3	68	0	117	14	0.106870229007634	TRUE	NA
ENSG00000145949.11	.	BCM	GRCh38.p13	chr6	2685322	2685322	+	C	C	A	Missense_Mutation	SNP	ENST00000274643.9	exon6	c.G519T	p.K173N	exonic	ENSG00000145949.11	.	nonsynonymous SNV	ENSG00000145949.11:ENST00000274643.9:exon6:c.G519T:p.K173N	6p25.2	C3N-01012	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	D	N	T	D	0.388	T	T	T	0.058	0.441	0.241	0.231	T	T	T	T	T	T	2.695	22.800	0.994	D	N	-0.308	1.595	-0.160	1.886	1.000	0.554	0.574	0.618	0.568	.	5.630	4.760	1.537	1.010	0.580	1.000	0.882	0.796	853	Protein_kinase_domain	.	.	.	MYLK4	94	0	205	14	0.0639269406392694	TRUE	TRUE
ENSG00000135355.4	.	BCM	GRCh38.p13	chr6	89894637	89894637	+	C	C	T	Missense_Mutation	SNP	ENST00000369352.1	exon1	c.C169T	p.R57W	exonic	ENSG00000135355.4	.	nonsynonymous SNV	ENSG00000135355.4:ENST00000369352.1:exon1:c.C169T:p.R57W	6q15	C3N-01012	5.767e-05	0	0	0.0001	0	0	0	0.0004	rs548704385	14.20	D	D	D	P	N	N	L	D	D	0.288	D	D	D	0.603	0.610	0.972	0.218	T	D	T	D	D	D	3.993	26.900	0.999	D	D	0.621	6.140	0.603	6.258	0.916	0.497	0.590	0.547	0.613	.	4.800	4.800	4.605	0.947	0.599	1.000	0.990	0.993	644	Connexin,_conserved_site;Connexin,_N-terminal	.	.	.	GJA10	170	0	335	20	0.0563380281690141	TRUE	NA
ENSG00000181072.11	.	BCM	GRCh38.p13	chr7	137016138	137016138	+	G	G	A	Missense_Mutation	SNP	ENST00000445907.6	exon3	c.G1273A	p.G425S	exonic	ENSG00000181072.11	.	nonsynonymous SNV	ENSG00000181072.11:ENST00000445907.6:exon3:c.G1273A:p.G425S	7q33	C3N-01012	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.827	T	T	D	0.610	0.553	0.966	1.505	D	T	D	D	D	D	4.177	28.400	0.998	D	D	0.712	7.290	0.740	8.563	1.000	0.487	0.574	0.574	0.564	.	5.810	5.810	9.940	1.176	0.618	1.000	0.989	0.962	833	GPCR,_rhodopsin-like,_7TM	.	.	.	CHRM2	120	0	172	20	0.104166666666667	TRUE	TRUE
ENSG00000132549.18	.	BCM	GRCh38.p13	chr8	99143057	99143057	+	A	A	G	Missense_Mutation	SNP	ENST00000358544.6	exon13	c.A1735G	p.I579V	exonic	ENSG00000132549.18	.	nonsynonymous SNV	ENSG00000132549.18:ENST00000358544.6:exon13:c.A1735G:p.I579V	8q22.2	C3N-01012	1.648e-05	0	0	0	0	2.997e-05	0	0	rs750419805	2.20	T	T	B	B	N	D	N	T	N	0.128	T	T	T	0.049	.	0.331	0.101	T	T	T	T	T	T	0.997	11.580	0.460	D	N	-0.581	1.022	-0.383	1.403	0.935	0.638	0.634	0.653	0.646	.	5.430	1.370	1.651	1.312	0.691	1.000	1.000	0.997	767	.	.	.	ID=COSV100662337;OCCURENCE=1(lung)	VPS13B	224	0	369	36	0.0888888888888889	TRUE	NA
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971112	21971112	+	G	G	A	Missense_Mutation	SNP	ENST00000304494.9	exon2	c.C247T	p.H83Y	exonic	ENSG00000147889.17	.	nonsynonymous SNV	ENSG00000147889.17:ENST00000304494.9:exon2:c.C247T:p.H83Y	9p21.3	C3N-01012	.	.	.	.	.	.	.	.	rs121913385	14.18	D	D	D	D	.	D	.	T	D	0.922	T	T	D	0.804	0.752	0.994	1.310	T	D	D	D	D	D	4.439	31	0.999	D	D	0.754	7.946	0.801	10.158	1.000	0.677	0.383	0.608	0.601	.	5.930	5.930	9.231	1.176	0.676	1.000	0.843	0.926	900	Ankyrin_repeat-containing_domain	.	.	ID=COSV58682852;OCCURENCE=1(salivary_gland),10(breast),7(penis),7(liver),10(oesophagus),2(large_intestine),5(central_nervous_system),5(biliary_tract),4(ovary),2(vulva),4(haematopoietic_and_lymphoid_tissue),2(stomach),3(soft_tissue),6(urinary_tract),25(pancreas),5(skin),14(lung),11(upper_aerodigestive_tract)	CDKN2A	631	0	1244	123	0.0899780541331383	NA	TRUE
ENSG00000180263.14	.	BCM	GRCh38.p13	chr12	95089642	95089642	+	C	C	T	Missense_Mutation	SNP	ENST00000343958.9	exon18	c.G3905A	p.S1302N	exonic	ENSG00000180263.14	.	nonsynonymous SNV	ENSG00000180263.14:ENST00000343958.9:exon18:c.G3905A:p.S1302N	12q22	C3N-01012	.	.	.	.	.	.	.	.	.	6.20	D	T	P	P	D	D	M	T	N	0.320	T	T	T	0.072	0.206	0.636	0.220	T	T	T	T	D	T	2.314	21.700	0.992	D	N	0.264	3.601	0.378	4.207	0.998	0.707	0.659	0.725	0.714	.	5.660	5.660	2.683	1.015	0.599	1.000	1.000	0.998	936	.	.	.	.	FGD6	140	0	285	16	0.053156146179402	TRUE	TRUE
ENSG00000135124.14	.	BCM	GRCh38.p13	chr12	121210249	121210249	+	G	G	A	Missense_Mutation	SNP	ENST00000337233.8	exon1	c.G85A	p.G29R	exonic	ENSG00000135124.14	.	nonsynonymous SNV	ENSG00000135124.14:ENST00000337233.8:exon1:c.G85A:p.G29R	12q24.31	C3N-01012	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	N	D	H	T	D	0.771	T	T	D	0.682	0.916	0.786	1.127	D	T	D	D	D	D	4.307	29.600	0.998	D	D	0.766	8.155	0.647	6.865	1.000	0.442	0.522	0.520	0.562	.	3.870	3.870	4.993	1.042	0.513	1.000	1.000	0.997	525	.	.	.	.	P2RX4	223	1	565	47	0.076797385620915	TRUE	NA
ENSG00000080618.16	.	BCM	GRCh38.p13	chr13	46073949	46073949	+	T	T	C	Missense_Mutation	SNP	ENST00000181383.10	exon6	c.A515G	p.N172S	exonic	ENSG00000080618.16	.	nonsynonymous SNV	ENSG00000080618.16:ENST00000181383.10:exon6:c.A515G:p.N172S	13q14.13	C3N-01012	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	N	N	L	T	N	0.091	T	T	T	0.033	0.555	0.316	0.306	T	T	T	T	T	T	1.593	16.330	0.986	D	N	-0.415	1.351	-0.255	1.660	0.970	0.487	0.547	0.574	0.542	.	5.170	2.650	0.877	1.138	0.665	1.000	1.000	0.997	602	Carboxypeptidase_B2;Peptidase_M14,_carboxypeptidase_A	.	.	.	CPB2	54	0	99	7	0.0660377358490566	TRUE	TRUE
ENSG00000103994.17	.	BCM	GRCh38.p13	chr15	42439309	42439316	+	GTGGAGGT	GTGGAGGT	-	Frame_Shift_Del	DEL	ENST00000263805.8	exon8	c.4192_4199del	p.T1398Lfs*16	exonic	ENSG00000103994.17	.	frameshift deletion	ENSG00000103994.17:ENST00000263805.8:exon8:c.4192_4199del:p.T1398Lfs*16	15q15.1	C3N-01012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF106	174	0	363	22	0.0571428571428571	NA	TRUE
ENSG00000136378.15	.	BCM	GRCh38.p13	chr15	78796723	78796723	+	C	C	T	Missense_Mutation	SNP	ENST00000388820.5	exon4	c.G686A	p.R229Q	exonic	ENSG00000136378.15	.	nonsynonymous SNV	ENSG00000136378.15:ENST00000388820.5:exon4:c.G686A:p.R229Q	15q25.1	C3N-01012	9.111e-06	0	0	0	0	1.695e-05	0	0	rs772813306	1.20	T	T	B	B	N	N	L	T	N	0.223	T	T	D	0.051	0.257	0.453	0.227	T	T	T	T	T	T	1.005	11.680	0.950	N	N	-0.839	0.600	-0.861	0.673	0.997	0.696	0.574	0.723	0.636	.	4.640	2.290	3.070	0.847	0.596	0.093	0.003	0.002	532	.	.	.	.	ADAMTS7	269	0	550	38	0.0646258503401361	TRUE	NA
ENSG00000140983.14	.	BCM	GRCh38.p13	chr16	670127	670127	+	G	G	A	Missense_Mutation	SNP	ENST00000315082.9	exon6	c.G281A	p.R94Q	exonic	ENSG00000140983.14	.	nonsynonymous SNV	ENSG00000140983.14:ENST00000315082.9:exon6:c.G281A:p.R94Q	16p13.3	C3N-01012	4.425e-05	0	0	0.0003	0	1.577e-05	0	8.158e-05	rs576916494	5.20	T	T	P	P	D	D	L	T	N	0.505	T	T	D	0.324	0.444	0.885	0.239	T	T	T	T	T	D	3.209	23.900	0.907	D	N	0.346	4.025	0.401	4.363	1.000	0.707	0.698	0.725	0.714	.	5.070	5.070	4.452	1.083	0.676	1.000	0.997	0.659	645	MIRO_domain;Small_GTP-binding_protein_domain	.	.	.	RHOT2	63	0	126	10	0.0735294117647059	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7675201	7675207	+	CAGTTGG	CAGTTGG	-	Frame_Shift_Del	DEL	ENST00000269305.8	exon5	c.405_411del	p.C135Wfs*33	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon5:c.405_411del:p.C135Wfs*33	17p13.1	C3N-01012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	240	0	513	40	0.0723327305605787	TRUE	TRUE
ENSG00000007174.18	.	BCM	GRCh38.p13	chr17	11669136	11669136	+	C	C	T	Missense_Mutation	SNP	ENST00000262442.9	exon16	c.C2804T	p.P935L	exonic	ENSG00000007174.18	.	nonsynonymous SNV	ENSG00000007174.18:ENST00000262442.9:exon16:c.C2804T:p.P935L	17p12	C3N-01012	8.247e-06	9.632e-05	0	0	0	0	0	0	rs556779874	12.19	T	.	D	P	D	D	H	T	D	0.988	T	T	D	0.570	0.588	0.756	0.470	T	T	D	D	D	D	3.081	23.600	0.997	D	D	0.588	5.801	0.468	4.880	1.000	0.487	0.574	0.233	0.564	.	5.410	5.410	7.539	1.026	0.599	1.000	0.784	0.584	854	.	.	.	ID=COSV52331561;OCCURENCE=1(breast),1(ovary),2(pancreas)	DNAH9	85	0	168	12	0.0666666666666667	TRUE	TRUE
ENSG00000171431.4	.	BCM	GRCh38.p13	chr17	40884840	40884840	+	C	C	A	Missense_Mutation	SNP	ENST00000167588.4	exon1	c.G346T	p.D116Y	exonic	ENSG00000171431.4	.	nonsynonymous SNV	ENSG00000171431.4:ENST00000167588.4:exon1:c.G346T:p.D116Y	17q21.2	C3N-01012	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.865	D	D	D	0.766	0.698	0.966	1.079	T	D	D	D	D	D	3.296	24.100	0.992	D	D	0.844	9.712	0.707	7.877	1.000	0.497	0.590	0.547	0.530	.	5.500	5.500	5.873	1.026	0.599	1.000	0.060	0.058	105	Intermediate_filament,_rod_domain	.	.	.	KRT20	134	0	251	33	0.116197183098592	TRUE	TRUE
ENSG00000142449.13	.	BCM	GRCh38.p13	chr19	8131716	8131716	+	C	C	T	Missense_Mutation	SNP	ENST00000600128.6	exon15	c.G1828A	p.V610M	exonic	ENSG00000142449.13	.	nonsynonymous SNV	ENSG00000142449.13:ENST00000600128.6:exon15:c.G1828A:p.V610M	19p13.2	C3N-01012	.	.	.	.	.	.	.	.	rs375756610	4.20	T	D	B	B	N	N	N	D	N	0.177	T	D	D	0.315	.	0.393	0.203	T	T	T	T	T	T	-0.958	0.010	0.859	N	N	-1.582	0.059	-1.721	0.047	0.001	0.696	0.547	0.723	0.613	.	3.020	-4.140	0.128	-1.247	-2.241	0.006	0.000	0.000	934	EGF-like_domain;EGF-like_calcium-binding_domain	.	.	ID=COSV54456688;OCCURENCE=1(liver),1(pancreas)	FBN3	261	0	598	64	0.0966767371601208	TRUE	TRUE
ENSG00000171223.6	.	BCM	GRCh38.p13	chr19	12792600	12792600	+	C	C	T	Missense_Mutation	SNP	ENST00000302754.6	exon1	c.C829T	p.R277W	exonic	ENSG00000171223.6	.	nonsynonymous SNV	ENSG00000171223.6:ENST00000302754.6:exon1:c.C829T:p.R277W	19p13.13	C3N-01012	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	U	D	H	T	D	0.734	T	T	D	0.638	0.708	0.791	.	D	T	D	D	D	D	4.225	28.900	0.999	D	.	0.520	5.191	0.353	4.041	1.000	0.442	0.522	0.474	0.373	.	3.720	2.650	0.268	0.938	0.589	0.981	1.000	1.000	520	Basic-leucine_zipper_domain	.	.	.	JUNB	332	0	740	79	0.0964590964590965	TRUE	TRUE
ENSG00000127527.14	.	BCM	GRCh38.p13	chr19	16418055	16418055	+	C	C	A	Missense_Mutation	SNP	ENST00000248070.10	exon11	c.G1000T	p.A334S	exonic	ENSG00000127527.14	.	nonsynonymous SNV	ENSG00000127527.14:ENST00000248070.10:exon11:c.G1000T:p.A334S	19p13.11	C3N-01012	.	.	.	.	.	.	.	.	.	5.20	T	T	P	P	D	D	L	T	N	0.407	T	T	T	0.090	0.394	0.277	0.632	T	T	T	T	D	D	2.732	22.900	0.994	D	N	0.070	2.769	0.104	2.749	1.000	0.713	0.672	0.780	0.692	.	4.450	4.450	1.995	0.947	0.599	1.000	0.992	0.994	964	EF-hand_domain;EH_domain	.	.	.	EPS15L1	124	0	333	26	0.0724233983286908	TRUE	TRUE
ENSG00000179954.16	.	BCM	GRCh38.p13	chr19	55489497	55489497	+	G	G	A	Missense_Mutation	SNP	ENST00000389623.11	exon3	c.G196A	p.A66T	exonic	ENSG00000179954.16	.	nonsynonymous SNV	ENSG00000179954.16:ENST00000389623.11:exon3:c.G196A:p.A66T	19q13.42	C3N-01012	.	.	.	.	.	.	.	.	.	10.20	D	D	D	D	N	D	M	T	D	0.400	T	T	D	0.423	0.772	0.672	0.109	D	T	T	T	D	T	3.412	24.400	0.999	N	N	0.290	3.727	0.137	2.892	1.000	0.609	0.514	0.769	0.568	.	3.930	3.930	2.276	1.089	0.498	0.708	0.362	0.117	970	SRCR_domain;SRCR-like_domain	.	.	.	SSC5D	114	0	244	16	0.0615384615384615	TRUE	NA
ENSG00000165194.15	.	BCM	GRCh38.p13	chrX	100402795	100402795	+	C	C	A	Missense_Mutation	SNP	ENST00000373034.8	exon3	c.G2345T	p.S782I	exonic	ENSG00000165194.15	.	nonsynonymous SNV	ENSG00000165194.15:ENST00000373034.8:exon3:c.G2345T:p.S782I	Xq22.1	C3N-01012	.	.	.	.	.	.	.	.	.	9.19	D	D	P	P	D	D	N	T	D	0.498	T	T	D	0.147	0.326	0.537	0.752	T	T	T	T	D	D	2.590	22.600	0.995	D	.	.	.	.	.	0.999	.	.	.	.	.	5.940	3.860	2.482	1.026	0.597	1.000	1.000	1.000	167	.	.	.	.	PCDH19	145	0	236	45	0.160142348754448	TRUE	TRUE
ENSG00000108443.14	.	BCM	GRCh38.p13	chr17	59934168	59934168	+	A	A	C	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000108443.14	ENST00000225577.9:exon8:c.689-2A>C	.	.	17q23.1	C3N-01012	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.350	34	0.980	D	.	1.032	14.962	0.863	12.252	0.220	0.164	0.157	0.232	0.221	0.862	5.320	4.250	8.888	1.215	0.653	1.000	1.000	0.997	305	.	.	.	.	RPS6KB1	85	0	182	12	0.0618556701030928	NA	TRUE
ENSG00000163531.15	.	BCM	GRCh38.p13	chr1	204954299	204954299	+	G	G	A	Silent	SNP	ENST00000339876.10	exon6	c.G327A	p.P109P	exonic	ENSG00000163531.15	.	synonymous SNV	ENSG00000163531.15:ENST00000339876.10:exon6:c.G327A:p.P109P	1q32.1	C3N-01012	9.938e-05	0.0003	0	0.0009	0	1.506e-05	0	0	rs202239718	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NFASC	197	0	514	31	0.0568807339449541	TRUE	NA
ENSG00000159239.13	.	BCM	GRCh38.p13	chr2	74414592	74414592	+	G	G	A	Silent	SNP	ENST00000517883.2	exon2	c.C1300T	p.L434L	exonic	ENSG00000159239.13;ENSG00000284308.1	.	synonymous SNV	ENSG00000159239.13:ENST00000517883.2:exon2:c.C1300T:p.L434L,ENSG00000284308.1:ENST00000612891.4:exon4:c.C1486T:p.L496L	2p13.1	C3N-01012	.	.	.	.	.	.	.	.	rs965251194	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC005041.1	94	0	228	30	0.116279069767442	TRUE	NA
ENSG00000188886.3	.	BCM	GRCh38.p13	chr2	96132664	96132664	+	C	C	T	Silent	SNP	ENST00000342380.2	exon6	c.G513A	p.T171T	exonic	ENSG00000188886.3	.	synonymous SNV	ENSG00000188886.3:ENST00000342380.2:exon6:c.G513A:p.T171T	2q11.2	C3N-01012	2.491e-05	0	8.655e-05	0	0	1.516e-05	0	6.067e-05	rs778436747	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ASTL	89	0	270	24	0.0816326530612245	TRUE	NA
ENSG00000144821.10	.	BCM	GRCh38.p13	chr3	108464698	108464698	+	C	C	T	Silent	SNP	ENST00000273353.4	exon16	c.G1731A	p.K577K	exonic	ENSG00000144821.10	.	synonymous SNV	ENSG00000144821.10:ENST00000273353.4:exon16:c.G1731A:p.K577K	3q13.13	C3N-01012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYH15	120	0	253	20	0.0732600732600733	TRUE	TRUE
ENSG00000164796.18	.	BCM	GRCh38.p13	chr8	112265496	112265496	+	T	T	C	Silent	SNP	ENST00000297405.10	exon60	c.A9603G	p.P3201P	exonic	ENSG00000164796.18	.	synonymous SNV	ENSG00000164796.18:ENST00000297405.10:exon60:c.A9603G:p.P3201P	8q23.3	C3N-01012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CSMD3	304	0	611	35	0.0541795665634675	TRUE	TRUE
ENSG00000148400.12	.	BCM	GRCh38.p13	chr9	136497466	136497466	+	A	A	G	Silent	SNP	ENST00000651671.1	exon34	c.T6273C	p.D2091D	exonic	ENSG00000148400.12	.	synonymous SNV	ENSG00000148400.12:ENST00000651671.1:exon34:c.T6273C:p.D2091D	9q34.3	C3N-01012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53101518;OCCURENCE=1(lung)	NOTCH1	181	0	341	34	0.0906666666666667	TRUE	TRUE
ENSG00000155495.9	.	BCM	GRCh38.p13	chrX	141908038	141908038	+	T	T	C	Silent	SNP	ENST00000285879.5	exon4	c.T2634C	p.Y878Y	exonic	ENSG00000155495.9	.	synonymous SNV	ENSG00000155495.9:ENST00000285879.5:exon4:c.T2634C:p.Y878Y	Xq27.2	C3N-01012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV53582181;OCCURENCE=1(large_intestine)	MAGEC1	98	0	169	44	0.206572769953052	TRUE	TRUE
ENSG00000197322.4	.	BCM	GRCh38.p13	chr17	34579232	34579232	+	C	C	G	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000197322.4	.	.	.	17q12	C3N-01012	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	C17orf102	131	0	304	21	0.0646153846153846	TRUE	NA
ENSG00000178821.13	.	BCM	GRCh38.p13	chr1	1917998	1917998	+	C	C	T	Missense_Mutation	SNP	ENST00000310991.8	exon5	c.G514A	p.A172T	exonic	ENSG00000178821.13	.	nonsynonymous SNV	ENSG00000178821.13:ENST00000310991.8:exon5:c.G514A:p.A172T	1p36.33	C3N-03426	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.069	T	T	T	0.031	0.059	0.014	0.046	T	T	T	T	T	T	0.153	2.602	0.879	N	N	-1.284	0.174	-1.330	0.190	1.000	0.767	0.610	0.851	0.605	.	4.040	-0.366	-0.190	-0.923	-0.830	0.000	0.000	0.000	923	.	.	.	.	TMEM52	360	0	556	132	0.191860465116279	TRUE	NA
ENSG00000162669.16	.	BCM	GRCh38.p13	chr1	91323169	91323169	+	G	G	C	Missense_Mutation	SNP	ENST00000370425.8	exon22	c.C2458G	p.L820V	exonic	ENSG00000162669.16	.	nonsynonymous SNV	ENSG00000162669.16:ENST00000370425.8:exon22:c.C2458G:p.L820V	1p22.2	C3N-03426	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.160	T	T	T	0.024	0.374	0.072	0.051	T	T	T	T	T	T	0.673	8.206	0.914	N	N	-0.979	0.427	-0.882	0.644	0.000	0.487	0.574	0.574	0.564	.	5.180	1.130	0.118	-0.169	-0.113	0.172	0.997	0.989	678	Sec63_domain	.	.	.	HFM1	161	0	261	60	0.186915887850467	TRUE	TRUE
ENSG00000060718.22	.	BCM	GRCh38.p13	chr1	103017870	103017870	+	G	G	A	Missense_Mutation	SNP	ENST00000370096.9	exon11	c.C1363T	p.P455S	exonic	ENSG00000060718.22	.	nonsynonymous SNV	ENSG00000060718.22:ENST00000370096.9:exon11:c.C1363T:p.P455S	1p21.1	C3N-03426	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	M	D	D	0.587	D	D	D	0.703	.	0.629	0.569	T	D	D	D	D	D	3.951	26.700	0.997	D	D	0.837	9.555	0.823	10.849	0.999	0.615	0.574	0.659	0.564	.	5.380	5.380	6.184	1.176	0.676	1.000	1.000	0.992	834	.	.	.	ID=COSV62191823;OCCURENCE=1(urinary_tract)	COL11A1	289	0	389	83	0.175847457627119	TRUE	TRUE
ENSG00000157181.16	.	BCM	GRCh38.p13	chr1	186393983	186393983	+	C	C	A	Missense_Mutation	SNP	ENST00000287859.11	exon9	c.C748A	p.H250N	exonic	ENSG00000157181.16	.	nonsynonymous SNV	ENSG00000157181.16:ENST00000287859.11:exon9:c.C748A:p.H250N	1q31.1	C3N-03426	.	.	.	.	.	.	.	.	.	1.19	T	T	B	B	N	D	L	T	N	0.191	T	T	T	0.026	0.385	0.115	0.151	.	T	T	T	T	T	1.752	17.390	0.954	N	N	-0.488	1.200	-0.375	1.418	1.000	0.757	0.744	0.744	0.657	.	5.340	4.430	2.392	1.026	0.599	0.034	0.928	0.847	386	.	.	.	.	ODR4	169	0	288	53	0.155425219941349	TRUE	TRUE
ENSG00000162687.18	.	BCM	GRCh38.p13	chr1	196326807	196326807	+	C	C	A	Missense_Mutation	SNP	ENST00000294725.13	exon19	c.G2186T	p.G729V	exonic	ENSG00000162687.18	.	nonsynonymous SNV	ENSG00000162687.18:ENST00000294725.13:exon19:c.G2186T:p.G729V	1q31.3	C3N-03426	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.915	T	D	D	0.580	0.360	0.693	1.353	D	T	D	D	D	D	3.118	23.700	0.997	D	D	0.637	6.321	0.662	7.093	1.000	0.554	0.574	0.602	0.564	.	5.280	5.280	7.905	1.026	0.599	1.000	1.000	0.999	520	.	.	.	.	KCNT2	83	0	142	44	0.236559139784946	TRUE	TRUE
ENSG00000162889.11	.	BCM	GRCh38.p13	chr1	206728734	206728734	+	C	C	T	Missense_Mutation	SNP	ENST00000367103.4	exon2	c.C304T	p.R102C	exonic	ENSG00000162889.11	.	nonsynonymous SNV	ENSG00000162889.11:ENST00000367103.4:exon2:c.C304T:p.R102C	1q32.1	C3N-03426	.	.	.	.	.	.	.	.	.	14.19	D	D	D	D	.	D	L	T	D	0.792	T	T	D	0.506	0.642	0.853	2.459	D	T	D	D	D	D	4.443	31	0.999	D	D	0.667	6.676	0.620	6.482	1.000	0.732	0.725	0.744	0.714	.	5.330	4.420	5.949	1.026	0.599	1.000	0.998	0.995	771	Protein_kinase_domain	.	.	.	MAPKAPK2	153	0	237	29	0.109022556390977	TRUE	TRUE
ENSG00000187554.14	.	BCM	GRCh38.p13	chr1	223112940	223112940	+	G	G	A	Missense_Mutation	SNP	ENST00000642603.2	exon6	c.C92T	p.A31V	exonic	ENSG00000187554.14	.	nonsynonymous SNV	ENSG00000187554.14:ENST00000642603.2:exon6:c.C92T:p.A31V	1q41	C3N-03426	.	.	.	.	.	.	.	.	.	14.16	D	D	.	.	D	D	.	D	D	0.468	D	D	D	0.384	0.309	0.918	0.263	T	.	D	T	D	D	3.284	24.100	0.999	D	D	0.243	3.498	0.165	3.015	1.000	0.646	0.590	0.645	0.613	.	4.750	4.750	6.874	1.176	0.676	1.000	0.005	0.004	756	.	.	.	.	TLR5	383	0	695	70	0.0915032679738562	TRUE	TRUE
ENSG00000162711.17	.	BCM	GRCh38.p13	chr1	247425220	247425220	+	G	G	A	Missense_Mutation	SNP	ENST00000336119.7	exon3	c.G1777A	p.E593K	exonic	ENSG00000162711.17	.	nonsynonymous SNV	ENSG00000162711.17:ENST00000336119.7:exon3:c.G1777A:p.E593K	1q44	C3N-03426	.	.	.	.	.	.	.	.	.	16.19	D	T	D	D	D	D	.	D	D	0.633	D	D	D	0.578	0.595	0.997	0.973	T	D	D	D	D	D	3.217	23.900	0.999	D	N	0.436	4.573	0.357	4.067	1.000	0.487	0.852	0.547	0.564	.	3.960	3.960	0.426	1.146	0.676	0.021	0.965	0.927	889	.	.	.	ID=COSV60221154;OCCURENCE=3(skin)	NLRP3	723	1	1106	253	0.18616629874908	TRUE	TRUE
ENSG00000196208.14	.	BCM	GRCh38.p13	chr2	11593083	11593083	+	C	C	G	Missense_Mutation	SNP	ENST00000381486.7	exon11	c.C1653G	p.C551W	exonic	ENSG00000196208.14	.	nonsynonymous SNV	ENSG00000196208.14:ENST00000381486.7:exon11:c.C1653G:p.C551W	2p25.1	C3N-03426	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	N	D	L	T	D	0.654	T	T	D	0.236	0.613	0.348	1.153	T	T	T	T	D	T	2.853	23.100	0.992	D	D	-0.024	2.428	-0.113	2.010	0.485	0.646	0.590	0.645	0.567	.	4.820	-1.230	0.097	-1.284	-0.289	0.963	0.867	0.987	921	.	.	.	.	GREB1	106	0	151	17	0.101190476190476	TRUE	TRUE
ENSG00000011523.14	.	BCM	GRCh38.p13	chr2	65071806	65071806	+	C	C	-	Frame_Shift_Del	DEL	ENST00000377990.7	exon3	c.710delC	p.S238Lfs*5	exonic	ENSG00000011523.14	.	frameshift deletion	ENSG00000011523.14:ENST00000377990.7:exon3:c.710delC:p.S238Lfs*5	2p14	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CEP68	73	0	129	15	0.104166666666667	TRUE	TRUE
ENSG00000116127.18	.	BCM	GRCh38.p13	chr2	73451542	73451542	+	T	T	C	Missense_Mutation	SNP	ENST00000613296.5	exon8	c.T5015C	p.V1672A	exonic	ENSG00000116127.18	.	nonsynonymous SNV	ENSG00000116127.18:ENST00000613296.5:exon8:c.T5015C:p.V1672A	2p13.1	C3N-03426	.	.	.	.	.	.	.	.	.	0.14	.	T	.	.	N	N	.	.	.	0.148	T	T	T	0.048	.	0.110	.	T	T	T	T	T	T	-0.803	0.025	0.606	N	N	-1.361	0.134	-1.423	0.140	1.000	0.732	0.617	0.744	0.684	.	4.050	-2.850	-1.473	-0.238	0.665	0.000	0.002	0.010	492	.	.	.	.	ALMS1	187	0	321	39	0.108333333333333	TRUE	NA
ENSG00000080345.18	.	BCM	GRCh38.p13	chr2	151440061	151440061	+	G	G	C	Missense_Mutation	SNP	ENST00000444746.7	exon15	c.G1581C	p.L527F	exonic	ENSG00000080345.18	.	nonsynonymous SNV	ENSG00000080345.18:ENST00000444746.7:exon15:c.G1581C:p.L527F	2q23.3	C3N-03426	.	.	.	.	.	.	.	.	.	10.20	T	D	D	D	D	D	M	T	N	0.665	T	T	D	0.230	0.208	0.344	0.294	T	T	T	T	D	D	2.759	22.900	0.999	D	N	0.340	3.993	0.276	3.580	0.141	0.707	0.577	0.696	0.714	.	5.040	3.210	0.941	1.176	0.613	1.000	0.983	0.924	819	.	.	.	.	RIF1	102	0	205	22	0.0969162995594714	TRUE	TRUE
ENSG00000155657.27	.	BCM	GRCh38.p13	chr2	178773946	178773946	+	G	G	T	Missense_Mutation	SNP	ENST00000591111.5	exon31	c.C7222A	p.Q2408K	exonic	ENSG00000155657.27	.	nonsynonymous SNV	ENSG00000155657.27:ENST00000591111.5:exon31:c.C7222A:p.Q2408K	2q31.2	C3N-03426	.	.	.	.	.	.	.	.	.	8.17	T	D	P	B	.	D	.	T	D	0.480	T	T	D	0.238	0.579	0.223	0.125	T	.	T	T	D	D	2.521	22.500	0.974	D	D	0.256	3.559	0.448	4.720	1.000	0.554	0.602	0.618	0.586	.	5.820	5.820	8.066	1.176	0.676	1.000	1.000	0.998	343	Immunoglobulin_I-set;Immunoglobulin-like_domain;Immunoglobulin_subtype	.	.	.	TTN	348	0	487	49	0.0914179104477612	TRUE	TRUE
ENSG00000170396.8	.	BCM	GRCh38.p13	chr2	184936001	184936001	+	A	A	C	Missense_Mutation	SNP	ENST00000302277.7	exon4	c.A605C	p.D202A	exonic	ENSG00000170396.8	.	nonsynonymous SNV	ENSG00000170396.8:ENST00000302277.7:exon4:c.A605C:p.D202A	2q32.1	C3N-03426	.	.	.	.	.	.	.	.	.	6.20	D	T	B	B	N	D	M	T	D	0.225	T	T	T	0.078	0.268	0.103	0.285	T	T	T	T	D	T	2.937	23.300	0.993	D	N	-0.138	2.057	-0.039	2.229	0.002	0.554	0.588	0.574	0.621	.	5.320	4.130	3.256	1.312	0.691	1.000	0.998	0.998	883	.	.	.	.	ZNF804A	171	0	283	38	0.118380062305296	TRUE	TRUE
ENSG00000177483.11	.	BCM	GRCh38.p13	chr2	237829332	237829332	+	G	G	T	Nonsense_Mutation	SNP	ENST00000316997.8	exon13	c.G2719T	p.E907X	exonic	ENSG00000177483.11	.	stopgain	ENSG00000177483.11:ENST00000316997.8:exon13:c.G2719T:p.E907X	2q37.3	C3N-03426	.	.	.	.	.	.	.	.	.	4.5	.	.	.	.	.	A	.	.	.	0.227	.	.	.	.	.	.	.	.	.	D	D	.	.	7.798	39	0.998	D	N	1.026	14.754	0.852	11.851	0.979	0.554	0.588	0.547	0.621	.	4.700	4.700	5.321	1.166	0.665	1.000	0.996	0.765	982	.	.	.	.	RBM44	175	0	309	40	0.114613180515759	TRUE	TRUE
ENSG00000168427.9	.	BCM	GRCh38.p13	chr2	238141086	238141086	+	C	C	T	Missense_Mutation	SNP	ENST00000409223.2	exon2	c.C332T	p.A111V	exonic	ENSG00000168427.9	.	nonsynonymous SNV	ENSG00000168427.9:ENST00000409223.2:exon2:c.C332T:p.A111V	2q37.3	C3N-03426	0.0001	0	8.76e-05	0.0013	0	0	0	0	rs539598913	4.20	D	D	P	B	N	N	N	T	N	0.151	T	T	D	0.087	0.337	0.697	0.442	T	T	T	T	T	T	1.951	18.880	0.998	D	N	-0.113	2.134	-0.076	2.116	1.000	0.428	0.547	0.547	0.613	.	5.750	3.770	3.635	1.026	0.599	1.000	0.021	0.010	969	BTB/POZ_domain	.	.	.	KLHL30	118	0	168	28	0.142857142857143	TRUE	NA
ENSG00000163939.18	.	BCM	GRCh38.p13	chr3	52587431	52587431	+	T	T	G	Missense_Mutation	SNP	ENST00000296302.11	exon19	c.A3045C	p.K1015N	exonic	ENSG00000163939.18	.	nonsynonymous SNV	ENSG00000163939.18:ENST00000296302.11:exon19:c.A3045C:p.K1015N	3p21.1	C3N-03426	.	.	.	.	.	.	.	.	.	14.20	D	T	D	D	D	D	N	D	D	0.751	T	D	D	0.495	0.778	0.817	1.201	D	D	T	T	D	D	3.074	23.600	0.996	D	N	-0.105	2.158	-0.043	2.218	0.000	0.732	0.744	0.725	0.728	.	5.920	2.270	-0.104	1.138	0.665	0.800	1.000	1.000	27	Bromo_adjacent_homology_(BAH)_domain	.	.	.	PBRM1	168	0	205	17	0.0765765765765766	NA	TRUE
ENSG00000180353.11	.	BCM	GRCh38.p13	chr3	121658316	121658316	+	G	G	T	Missense_Mutation	SNP	ENST00000314583.8	exon2	c.C32A	p.S11Y	exonic	ENSG00000180353.11	.	nonsynonymous SNV	ENSG00000180353.11:ENST00000314583.8:exon2:c.C32A:p.S11Y	3q13.33	C3N-03426	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	N	D	M	T	D	0.510	T	T	T	0.233	0.327	0.677	0.384	T	D	D	T	D	D	3.805	25.900	0.995	D	D	0.655	6.534	0.621	6.497	1.000	0.732	0.686	0.602	0.728	.	4.980	4.980	4.958	1.176	0.676	1.000	1.000	0.998	336	.	.	.	.	HCLS1	124	0	264	24	0.0833333333333333	TRUE	TRUE
ENSG00000284862.3	.	BCM	GRCh38.p13	chr3	180619363	180619363	+	C	C	T	Missense_Mutation	SNP	ENST00000476379.6	exon16	c.G2161A	p.D721N	exonic	ENSG00000284862.3	.	nonsynonymous SNV	ENSG00000284862.3:ENST00000476379.6:exon16:c.G2161A:p.D721N	3q26.33	C3N-03426	.	.	.	.	.	.	.	.	.	6.19	T	D	P	B	.	D	L	T	N	0.142	T	T	D	0.244	0.128	0.860	0.064	T	T	T	T	D	D	2.757	22.900	0.994	D	N	0.040	2.656	0.105	2.754	0.045	0.554	0.588	0.574	0.613	.	5.690	3.800	2.788	1.026	0.599	1.000	0.986	0.228	601	.	.	.	.	CCDC39	114	0	271	20	0.0687285223367698	TRUE	TRUE
ENSG00000134853.12	.	BCM	GRCh38.p13	chr4	54295213	54295213	+	G	G	A	Missense_Mutation	SNP	ENST00000257290.10	exon23	c.G3211A	p.D1071N	exonic	ENSG00000134853.12;ENSG00000282278.1	.	nonsynonymous SNV	ENSG00000134853.12:ENST00000257290.10:exon23:c.G3211A:p.D1071N,ENSG00000282278.1:ENST00000507166.5:exon24:c.G2491A:p.D831N	4q12	C3N-03426	4.118e-05	9.61e-05	0	0	0	4.495e-05	0	6.056e-05	rs376544204	6.20	D	T	P	B	U	D	L	T	N	0.302	T	T	D	0.317	.	0.387	0.074	T	T	T	T	T	D	2.904	23.200	0.999	D	D	0.236	3.467	0.386	4.261	0.998	0.549	0.574	0.618	0.616	.	5.840	5.000	6.097	1.146	0.676	1.000	1.000	0.999	422	.	.	.	ID=COSV57264427;OCCURENCE=1(breast),1(penis),2(large_intestine),2(lung),4(endometrium)	PDGFRA	271	0	364	57	0.135391923990499	TRUE	TRUE
ENSG00000169248.13	.	BCM	GRCh38.p13	chr4	76035319	76035319	+	G	G	A	Missense_Mutation	SNP	ENST00000306621.8	exon2	c.C85T	p.R29C	exonic	ENSG00000169248.13	.	nonsynonymous SNV	ENSG00000169248.13:ENST00000306621.8:exon2:c.C85T:p.R29C	4q21.1	C3N-03426	4.971e-05	0.0002	0	0.0001	0	1.508e-05	0	0.0001	rs377189872	8.19	D	D	B	B	D	D	.	T	D	0.810	T	T	D	0.223	0.926	0.373	0.181	T	D	T	T	T	D	2.399	22.100	0.987	N	N	-0.398	1.388	-0.390	1.390	1.000	0.615	0.476	0.618	0.655	.	5.370	3.620	1.210	0.222	0.676	0.534	0.569	0.335	879	Chemokine_interleukin-8-like_domain;CXC_Chemokine_domain	.	.	ID=COSV60666552;OCCURENCE=1(large_intestine),1(stomach),1(endometrium)	CXCL11	244	0	370	55	0.129411764705882	TRUE	TRUE
ENSG00000185149.6	.	BCM	GRCh38.p13	chr4	155214274	155214274	+	T	T	C	Missense_Mutation	SNP	ENST00000329476.4	exon2	c.T335C	p.L112S	exonic	ENSG00000185149.6	.	nonsynonymous SNV	ENSG00000185149.6:ENST00000329476.4:exon2:c.T335C:p.L112S	4q32.1	C3N-03426	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.930	D	D	D	0.887	0.774	0.972	1.214	T	T	D	D	D	D	4.080	27.600	0.999	D	D	0.861	10.087	0.818	10.665	1.000	0.487	0.574	0.574	0.542	.	5.440	5.440	8.010	1.138	0.654	0.998	0.998	0.996	651	GPCR,_rhodopsin-like,_7TM	.	.	.	NPY2R	156	0	270	37	0.120521172638436	TRUE	TRUE
ENSG00000256394.3	.	BCM	GRCh38.p13	chr4	155836690	155836690	+	T	T	A	Missense_Mutation	SNP	ENST00000537611.3	exon8	c.A1234T	p.R412W	exonic	ENSG00000256394.3	.	nonsynonymous SNV	ENSG00000256394.3:ENST00000537611.3:exon8:c.A1234T:p.R412W	4q32.1	C3N-03426	.	.	.	.	.	.	.	.	.	15.20	D	D	D	D	D	D	M	T	D	0.841	T	T	D	0.463	0.387	0.625	0.098	T	T	D	D	D	D	5.249	33	0.999	D	D	0.486	4.929	0.341	3.962	0.000	0.487	0.574	0.574	0.564	.	4.800	2.320	3.502	0.142	0.665	1.000	0.992	0.887	917	.	.	.	.	ASIC5	66	0	126	21	0.142857142857143	TRUE	TRUE
ENSG00000040731.10	.	BCM	GRCh38.p13	chr5	24487902	24487902	+	C	C	T	Missense_Mutation	SNP	ENST00000264463.8	exon12	c.G2128A	p.V710I	exonic	ENSG00000040731.10	.	nonsynonymous SNV	ENSG00000040731.10:ENST00000264463.8:exon12:c.G2128A:p.V710I	5p14.2	C3N-03426	1.649e-05	0	0	0.0002	0	0	0	0	rs560951980	6.20	T	T	D	P	D	D	L	T	N	0.411	T	T	T	0.335	0.547	0.753	1.144	T	T	T	T	D	T	2.937	23.300	0.999	D	D	0.403	4.361	0.496	5.120	1.000	0.487	0.574	0.574	0.564	.	5.410	5.410	6.103	1.022	0.596	1.000	0.999	0.999	858	Cadherin,_cytoplasmic_domain	.	.	ID=COSV52600093;OCCURENCE=1(lung)	CDH10	352	0	556	64	0.103225806451613	TRUE	TRUE
ENSG00000168724.17	.	BCM	GRCh38.p13	chr5	34938958	34938958	+	G	G	A	Missense_Mutation	SNP	ENST00000648817.1	exon6	c.G844A	p.G282R	exonic	ENSG00000168724.17	.	nonsynonymous SNV	ENSG00000168724.17:ENST00000648817.1:exon6:c.G844A:p.G282R	5p13.2	C3N-03426	.	.	.	.	.	.	.	.	.	6.20	T	T	P	B	N	D	M	T	N	0.327	T	T	T	0.137	0.275	0.533	0.073	T	T	T	T	D	D	3.121	23.700	0.998	D	D	0.181	3.221	0.334	3.918	1.000	0.707	0.725	0.725	0.714	.	6.170	6.170	6.344	1.176	0.676	1.000	0.956	0.759	528	.	.	.	.	DNAJC21	168	0	274	68	0.198830409356725	TRUE	TRUE
ENSG00000133302.13	.	BCM	GRCh38.p13	chr5	94694992	94694992	+	G	G	C	Missense_Mutation	SNP	ENST00000265140.10	exon21	c.G2857C	p.E953Q	exonic	ENSG00000133302.13	.	nonsynonymous SNV	ENSG00000133302.13:ENST00000265140.10:exon21:c.G2857C:p.E953Q	5q15	C3N-03426	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	D	D	.	T	N	0.590	T	T	T	0.270	0.367	0.735	0.406	T	T	T	T	D	T	3.810	25.900	0.998	D	D	0.686	6.929	0.711	7.956	1.000	0.660	0.654	0.659	0.592	.	5.460	5.460	6.883	1.172	0.613	1.000	1.000	0.999	847	.	.	.	.	SLF1	108	0	250	25	0.0909090909090909	TRUE	TRUE
ENSG00000133302.13	.	BCM	GRCh38.p13	chr5	94694997	94694997	+	T	T	G	Missense_Mutation	SNP	ENST00000265140.10	exon21	c.T2862G	p.F954L	exonic	ENSG00000133302.13	.	nonsynonymous SNV	ENSG00000133302.13:ENST00000265140.10:exon21:c.T2862G:p.F954L	5q15	C3N-03426	.	.	.	.	.	.	.	.	rs767172390	3.19	T	T	P	B	D	D	.	T	N	0.102	T	T	T	0.062	.	0.466	0.121	T	T	T	T	T	T	1.805	17.760	0.994	D	N	-0.264	1.705	-0.163	1.876	0.998	0.660	0.654	0.659	0.592	.	5.460	1.500	1.286	0.194	0.604	1.000	0.998	0.998	847	.	.	.	.	SLF1	100	21	239	21	0.0807692307692308	TRUE	NA
ENSG00000113441.16	.	BCM	GRCh38.p13	chr5	96979473	96979473	+	G	G	A	Missense_Mutation	SNP	ENST00000231368.10	exon2	c.G355A	p.V119M	exonic	ENSG00000113441.16	.	nonsynonymous SNV	ENSG00000113441.16:ENST00000231368.10:exon2:c.G355A:p.V119M	5q15	C3N-03426	8.246e-06	0	0	0	0	1.499e-05	0	0	rs763065052	6.20	D	T	D	P	N	D	L	T	N	0.260	T	T	D	0.149	.	0.162	0.460	T	T	T	T	T	D	1.685	16.930	0.998	D	N	0.014	2.562	-0.042	2.220	1.000	0.707	0.725	0.602	0.714	.	6.070	4.240	2.133	1.176	0.618	0.998	0.102	0.143	869	.	.	.	.	LNPEP	197	0	303	38	0.111436950146628	TRUE	NA
ENSG00000145901.15	.	BCM	GRCh38.p13	chr5	151036804	151036804	+	A	A	T	Missense_Mutation	SNP	ENST00000315050.11	exon13	c.T1381A	p.L461M	exonic	ENSG00000145901.15	.	nonsynonymous SNV	ENSG00000145901.15:ENST00000315050.11:exon13:c.T1381A:p.L461M	5q33.1	C3N-03426	.	.	.	.	.	.	.	.	.	11.20	D	T	D	P	D	N	N	D	N	0.478	D	D	D	0.364	0.202	0.378	0.775	D	T	D	T	D	D	2.746	22.900	0.990	N	N	-0.250	1.740	-0.414	1.348	1.000	0.732	0.698	0.744	0.714	.	5.530	-4.100	0.780	0.283	-0.065	0.411	0.987	0.887	803	NF-kappa-B_essential_modulator_NEMO,_CC2-LZ_domain	.	.	.	TNIP1	211	0	345	31	0.0824468085106383	TRUE	TRUE
ENSG00000170613.4	.	BCM	GRCh38.p13	chr5	157162827	157162827	+	T	T	G	Missense_Mutation	SNP	ENST00000302938.4	exon2	c.A1438C	p.K480Q	exonic	ENSG00000170613.4	.	nonsynonymous SNV	ENSG00000170613.4:ENST00000302938.4:exon2:c.A1438C:p.K480Q	5q33.3	C3N-03426	0.0003	0.0031	0.0003	0	0	0	0	0	rs148949971	3.20	D	T	D	P	N	N	M	T	N	0.068	T	T	T	0.054	.	0.102	0.140	T	T	T	T	T	T	2.183	20.700	0.948	N	N	0.025	2.600	-0.158	1.891	0.064	0.487	0.547	0.574	0.564	.	4.640	3.450	0.753	0.197	0.665	0.907	0.174	0.239	558	.	.	.	.	FAM71B	378	0	536	53	0.0899830220713073	TRUE	NA
ENSG00000164330.17	.	BCM	GRCh38.p13	chr5	158796368	158796368	+	C	C	T	Missense_Mutation	SNP	ENST00000313708.11	exon9	c.G886A	p.G296S	exonic	ENSG00000164330.17	.	nonsynonymous SNV	ENSG00000164330.17:ENST00000313708.11:exon9:c.G886A:p.G296S	5q33.3	C3N-03426	.	.	.	.	.	.	.	.	.	20.20	D	D	D	D	D	D	M	D	D	0.914	D	D	D	0.905	0.817	0.945	2.226	D	D	D	D	D	D	3.954	26.700	0.999	D	D	0.948	12.371	0.914	14.382	1.000	0.707	0.725	0.574	0.564	.	5.680	5.680	7.905	1.026	0.599	1.000	1.000	1.000	786	IPT_domain;Transcription_factor_COE,_IPT_domain	.	.	.	EBF1	113	0	194	22	0.101851851851852	TRUE	TRUE
ENSG00000145934.16	.	BCM	GRCh38.p13	chr5	168190405	168190405	+	C	C	T	Missense_Mutation	SNP	ENST00000518659.5	exon14	c.C2638T	p.R880W	exonic	ENSG00000145934.16	.	nonsynonymous SNV	ENSG00000145934.16:ENST00000518659.5:exon14:c.C2638T:p.R880W	5q34	C3N-03426	5.848e-05	0	0	0.0008	0	0	0	0	rs748990955	17.20	D	D	D	D	D	D	M	T	D	0.826	D	D	D	0.559	0.533	0.337	1.255	D	T	T	D	D	D	3.946	26.600	0.999	D	D	0.575	5.674	0.560	5.761	1.000	0.554	0.588	0.574	0.564	.	5.940	5.060	3.122	1.026	0.599	1.000	1.000	0.999	910	.	.	.	ID=COSV69133491;OCCURENCE=1(large_intestine)	TENM2	183	0	240	39	0.139784946236559	TRUE	TRUE
ENSG00000134516.18	.	BCM	GRCh38.p13	chr5	170050275	170050275	+	G	G	A	Missense_Mutation	SNP	ENST00000520908.7	exon41	c.G4091A	p.R1364H	exonic	ENSG00000134516.18	.	nonsynonymous SNV	ENSG00000134516.18:ENST00000520908.7:exon41:c.G4091A:p.R1364H	5q35.1	C3N-03426	8.248e-06	0	0	0	0	1.501e-05	0	0	rs769663046	14.20	D	D	D	D	D	D	M	T	D	0.821	T	T	D	0.473	0.620	0.776	1.630	T	T	D	T	D	D	4.616	32	0.999	D	D	1.041	15.255	0.968	16.995	1.000	0.707	0.725	0.653	0.613	.	5.420	5.420	10.003	1.176	0.676	1.000	0.929	0.793	964	DHR-2_domain;Dedicator_of_cytokinesis,_C-terminal	.	.	ID=COSV56987375;OCCURENCE=1(stomach),1(upper_aerodigestive_tract)	DOCK2	114	0	195	29	0.129464285714286	TRUE	TRUE
ENSG00000169220.18	.	BCM	GRCh38.p13	chr5	177371201	177371201	+	G	G	A	Missense_Mutation	SNP	ENST00000408923.8	exon12	c.G1291A	p.V431M	exonic	ENSG00000169220.18	.	nonsynonymous SNV	ENSG00000169220.18:ENST00000408923.8:exon12:c.G1291A:p.V431M	5q35.3	C3N-03426	.	.	.	.	.	.	.	.	.	13.20	D	D	D	D	D	D	M	T	N	0.657	T	T	D	0.290	0.591	0.765	1.165	T	D	T	T	D	D	4.362	31	0.999	D	D	0.708	7.226	0.683	7.448	1.000	0.733	0.639	0.601	0.604	.	5.570	5.570	4.810	1.079	0.667	1.000	0.980	0.858	934	Raf-like_Ras-binding	.	.	.	RGS14	233	0	394	43	0.0983981693363844	TRUE	TRUE
ENSG00000124802.12	.	BCM	GRCh38.p13	chr6	8090202	8090202	+	C	C	T	Missense_Mutation	SNP	ENST00000379715.10	exon3	c.G368A	p.G123E	exonic	ENSG00000124802.12;ENSG00000265818.1	.	nonsynonymous SNV	ENSG00000124802.12:ENST00000379715.10:exon3:c.G368A:p.G123E,ENSG00000265818.1:ENST00000397456.2:exon3:c.G368A:p.G123E	6p24.3	C3N-03426	.	.	.	.	.	.	.	.	.	14.20	D	T	D	D	D	D	M	T	D	0.968	T	T	D	0.347	0.657	0.576	1.109	T	T	D	D	D	D	4.096	27.700	0.998	D	D	0.686	6.934	0.651	6.923	1.000	0.732	0.744	0.744	0.728	.	4.960	4.960	6.954	1.026	0.599	1.000	0.994	0.999	898	Glutathione_S-transferase,_C-terminal-like;Glutathione_S-transferase,_C-terminal	.	.	.	EEF1E1	47	0	137	10	0.0680272108843537	TRUE	TRUE
ENSG00000197935.6	.	BCM	GRCh38.p13	chr6	28998786	28998786	+	G	G	C	Missense_Mutation	SNP	ENST00000377179.3	exon6	c.C363G	p.D121E	exonic	ENSG00000197935.6	.	nonsynonymous SNV	ENSG00000197935.6:ENST00000377179.3:exon6:c.C363G:p.D121E	6p22.1	C3N-03426	.	.	.	.	.	.	.	.	.	0.18	T	T	B	B	.	N	N	T	N	0.034	T	T	T	0.064	0.371	0.146	0.175	T	T	T	T	T	.	-0.476	0.133	0.222	N	N	-1.216	0.216	-1.136	0.340	0.008	0.615	0.590	0.659	0.568	.	3.730	1.720	-1.726	0.007	-0.231	0.000	0.026	0.115	749	Krueppel-associated_box	.	.	.	ZNF311	205	0	343	34	0.0901856763925729	TRUE	TRUE
ENSG00000096060.14	.	BCM	GRCh38.p13	chr6	35642769	35642769	+	G	G	T	Missense_Mutation	SNP	ENST00000536438.5	exon3	c.C56A	p.A19D	exonic	ENSG00000096060.14	.	nonsynonymous SNV	ENSG00000096060.14:ENST00000536438.5:exon3:c.C56A:p.A19D	6p21.31	C3N-03426	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	N	D	L	D	N	0.194	T	T	T	0.296	0.224	0.973	0.466	T	T	T	T	D	T	1.927	18.690	0.983	D	N	0.163	3.144	0.230	3.332	0.950	0.719	0.723	0.710	0.714	.	5.950	5.080	2.498	1.176	0.676	1.000	0.490	0.730	581	.	.	.	.	FKBP5	157	0	306	34	0.1	TRUE	TRUE
ENSG00000001084.13	.	BCM	GRCh38.p13	chr6	53514486	53514486	+	C	C	G	Missense_Mutation	SNP	ENST00000650454.1	exon5	c.G572C	p.R191T	exonic	ENSG00000001084.13	.	nonsynonymous SNV	ENSG00000001084.13:ENST00000650454.1:exon5:c.G572C:p.R191T	6p12.1	C3N-03426	.	.	.	.	.	.	.	.	.	16.20	D	T	D	D	D	D	M	T	D	0.865	T	T	D	0.551	0.442	0.724	1.728	D	D	D	D	D	D	3.701	25.400	0.962	D	D	0.849	9.814	0.834	11.220	1.000	0.707	0.709	0.725	0.714	.	5.940	5.940	7.472	1.026	0.599	1.000	1.000	0.997	697	.	.	.	.	GCLC	344	0	561	71	0.112341772151899	TRUE	TRUE
ENSG00000112245.12	.	BCM	GRCh38.p13	chr6	63578898	63578898	+	G	G	A	Missense_Mutation	SNP	ENST00000648894.1	exon6	c.G199A	p.D67N	exonic	ENSG00000112245.12	.	nonsynonymous SNV	ENSG00000112245.12:ENST00000648894.1:exon6:c.G199A:p.D67N	6q12	C3N-03426	.	.	.	.	.	.	.	.	.	10.17	.	T	B	B	D	D	M	.	.	0.378	T	D	D	0.426	0.543	0.540	.	T	D	T	T	D	D	4.270	29.300	0.999	D	D	0.287	3.712	0.429	4.569	1.000	0.707	0.581	0.702	0.714	.	5.660	5.660	7.861	1.102	0.505	1.000	1.000	0.992	796	Protein-tyrosine_phosphatase,_catalytic;Dual_specificity_phosphatase,_catalytic_domain	.	.	.	PTP4A1	38	0	92	8	0.08	TRUE	TRUE
ENSG00000135346.8	.	BCM	GRCh38.p13	chr6	87086429	87086429	+	G	G	A	Missense_Mutation	SNP	ENST00000627148.2	exon3	c.C94T	p.P32S	exonic	ENSG00000135346.8	.	nonsynonymous SNV	ENSG00000135346.8:ENST00000627148.2:exon3:c.C94T:p.P32S	6q14.3	C3N-03426	.	.	.	.	.	.	.	.	.	9.19	T	T	D	D	D	D	M	.	N	0.471	T	T	T	0.230	0.410	0.450	1.803	T	T	T	T	D	D	2.596	22.600	0.998	D	D	0.408	4.395	0.393	4.312	0.674	0.487	0.547	0.547	0.564	.	5.050	5.050	4.973	1.176	0.618	1.000	0.997	0.253	824	.	.	.	.	CGA	51	0	144	12	0.0769230769230769	TRUE	TRUE
ENSG00000164418.20	.	BCM	GRCh38.p13	chr6	101928577	101928577	+	A	A	G	Missense_Mutation	SNP	ENST00000421544.6	exon16	c.A2030G	p.Q677R	exonic	ENSG00000164418.20	.	nonsynonymous SNV	ENSG00000164418.20:ENST00000421544.6:exon16:c.A2030G:p.Q677R	6q16.3	C3N-03426	.	.	.	.	.	.	.	.	.	17.20	D	D	D	D	D	D	M	T	D	0.842	T	T	D	0.698	0.879	0.860	2.243	D	D	D	D	D	D	3.929	26.500	0.999	D	D	0.972	13.057	0.919	14.574	1.000	0.554	0.574	0.618	0.564	.	5.810	5.810	9.255	1.233	0.665	1.000	1.000	0.999	861	Ionotropic_glutamate_receptor	.	.	.	GRIK2	342	0	506	57	0.101243339253996	TRUE	TRUE
ENSG00000131018.24	.	BCM	GRCh38.p13	chr6	152455482	152455482	+	C	C	T	Missense_Mutation	SNP	ENST00000367255.10	exon24	c.G2836A	p.A946T	exonic	ENSG00000131018.24	.	nonsynonymous SNV	ENSG00000131018.24:ENST00000367255.10:exon24:c.G2836A:p.A946T	6q25.2	C3N-03426	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.813	T	T	D	0.325	0.316	0.683	0.596	T	D	D	D	D	D	3.163	23.800	0.999	D	D	0.713	7.305	0.688	7.534	1.000	0.554	0.590	0.624	0.568	.	5.480	5.480	7.514	1.026	0.599	1.000	0.746	0.957	686	.	.	.	.	SYNE1	155	0	255	36	0.123711340206186	TRUE	TRUE
ENSG00000106305.10	.	BCM	GRCh38.p13	chr7	6015217	6015217	+	G	G	T	Missense_Mutation	SNP	ENST00000223029.8	exon2	c.G207T	p.L69F	exonic	ENSG00000106305.10	.	nonsynonymous SNV	ENSG00000106305.10:ENST00000223029.8:exon2:c.G207T:p.L69F	7p22.1	C3N-03426	.	.	.	.	.	.	.	.	.	16.20	D	D	D	D	D	D	M	T	D	0.743	D	T	D	0.364	0.443	0.651	0.251	T	T	D	D	D	D	3.908	26.400	0.999	D	D	0.753	7.938	0.705	7.839	1.000	0.646	0.696	0.702	0.742	.	5.260	5.260	3.423	1.176	0.676	1.000	1.000	1.000	814	.	.	.	.	AIMP2	309	0	576	68	0.105590062111801	TRUE	TRUE
ENSG00000180347.13	.	BCM	GRCh38.p13	chr7	31643166	31643166	+	C	C	T	Missense_Mutation	SNP	ENST00000407970.7	exon11	c.C1796T	p.S599L	exonic	ENSG00000180347.13	.	nonsynonymous SNV	ENSG00000180347.13:ENST00000407970.7:exon11:c.C1796T:p.S599L	7p14.3	C3N-03426	.	.	.	.	.	.	.	.	.	3.19	D	D	B	B	N	N	.	T	D	0.146	T	T	T	0.059	0.165	0.240	0.043	T	T	T	T	T	T	1.544	16.020	0.996	N	N	-0.517	1.143	-0.593	1.057	0.427	0.554	0.590	0.602	0.564	.	6.020	1.880	0.283	1.026	0.599	0.000	0.037	0.244	803	.	.	.	.	ITPRID1	168	0	326	26	0.0738636363636364	TRUE	TRUE
ENSG00000180347.13	.	BCM	GRCh38.p13	chr7	31643174	31643174	+	A	A	T	Missense_Mutation	SNP	ENST00000407970.7	exon11	c.A1804T	p.N602Y	exonic	ENSG00000180347.13	.	nonsynonymous SNV	ENSG00000180347.13:ENST00000407970.7:exon11:c.A1804T:p.N602Y	7p14.3	C3N-03426	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	.	T	N	0.244	T	T	T	0.034	0.109	0.407	0.042	T	T	T	T	T	T	0.270	3.936	0.960	N	N	-0.744	0.740	-0.786	0.778	0.484	0.554	0.590	0.602	0.564	.	6.020	2.240	0.459	1.312	0.756	0.000	0.036	0.309	803	.	.	.	ID=COSV100086850;OCCURENCE=1(central_nervous_system)	ITPRID1	162	0	326	28	0.0790960451977401	TRUE	TRUE
ENSG00000128573.26	.	BCM	GRCh38.p13	chr7	114652252	114652252	+	C	C	T	Nonsense_Mutation	SNP	ENST00000350908.9	exon9	c.C1144T	p.R382X	exonic	ENSG00000128573.26	.	stopgain	ENSG00000128573.26:ENST00000350908.9:exon9:c.C1144T:p.R382X	7q31.1	C3N-03426	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.966	.	.	.	.	.	.	.	.	.	D	D	.	.	7.264	37	0.998	D	N	0.857	9.992	0.752	8.843	0.995	0.554	0.486	0.489	0.568	.	5.800	5.800	2.611	0.102	-0.224	1.000	1.000	0.990	760	FOXP,_coiled-coil_domain	.	.	.	FOXP2	356	0	612	66	0.0973451327433628	TRUE	TRUE
ENSG00000105967.16	.	BCM	GRCh38.p13	chr7	115984375	115984375	+	C	C	A	Missense_Mutation	SNP	ENST00000265440.12	exon2	c.G67T	p.G23W	exonic	ENSG00000105967.16	.	nonsynonymous SNV	ENSG00000105967.16:ENST00000265440.12:exon2:c.G67T:p.G23W	7q31.2	C3N-03426	.	.	.	.	.	.	.	.	.	4.20	D	D	D	P	N	N	N	T	N	0.405	T	T	T	0.076	0.410	0.170	0.124	T	T	T	T	D	T	1.222	13.810	0.966	N	N	-0.587	1.012	-0.710	0.885	0.971	0.706	0.670	0.574	0.613	.	5.090	0.691	-0.501	0.138	0.599	0.000	0.000	0.005	750	.	.	.	.	TFEC	416	0	722	64	0.0814249363867685	TRUE	TRUE
ENSG00000128524.5	.	BCM	GRCh38.p13	chr7	128862914	128862914	+	-	NA	G	Nonsense_Mutation	SNP	ENST00000249289.5	exon1	c.11dupG	p.K6*	exonic	ENSG00000128524.5	.	stopgain	ENSG00000128524.5:ENST00000249289.5:exon1:c.11dupG:p.K6*	7q32.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ATP6V1F	NA	NA	NA	NA	NA	NA	NA
ENSG00000157168.20	.	BCM	GRCh38.p13	chr8	32759348	32759348	+	G	G	C	Missense_Mutation	SNP	ENST00000405005.7	exon10	c.G973C	p.E325Q	exonic	ENSG00000157168.20	.	nonsynonymous SNV	ENSG00000157168.20:ENST00000405005.7:exon10:c.G973C:p.E325Q	8p12	C3N-03426	.	.	.	.	.	.	.	.	.	11.20	D	T	D	D	D	D	M	T	N	0.565	T	T	D	0.286	0.529	0.568	0.814	T	T	T	T	D	D	3.919	26.500	0.998	D	D	0.810	8.984	0.839	11.394	0.994	0.707	0.588	0.602	0.714	.	6.160	6.160	7.051	1.176	0.676	1.000	0.998	0.992	835	Neuregulin,_C-terminal	.	.	.	NRG1	131	0	221	27	0.108870967741935	TRUE	TRUE
ENSG00000206579.9	.	BCM	GRCh38.p13	chr8	55102690	55102690	+	T	T	A	Missense_Mutation	SNP	ENST00000327381.7	exon1	c.T202A	p.C68S	exonic	ENSG00000206579.9	.	nonsynonymous SNV	ENSG00000206579.9:ENST00000327381.7:exon1:c.T202A:p.C68S	8q12.1	C3N-03426	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	N	N	D	N	0.265	T	T	D	0.194	0.487	0.043	0.786	D	T	T	T	T	T	2.038	19.540	0.936	N	N	-0.568	1.047	-0.435	1.310	0.994	0.598	0.542	0.504	0.639	.	3.510	2.310	0.061	0.987	0.519	0.996	0.995	0.972	885	.	.	.	.	XKR4	34	0	53	3	0.0535714285714286	TRUE	NA
ENSG00000155100.11	.	BCM	GRCh38.p13	chr8	91078412	91078412	+	T	T	G	Missense_Mutation	SNP	ENST00000404789.8	exon4	c.T372G	p.I124M	exonic	ENSG00000155100.11	.	nonsynonymous SNV	ENSG00000155100.11:ENST00000404789.8:exon4:c.T372G:p.I124M	8q21.3	C3N-03426	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	D	D	N	T	N	0.338	T	T	T	0.095	0.385	0.475	0.132	T	T	T	T	T	T	2.714	22.900	0.753	D	N	-0.080	2.240	-0.001	2.356	0.997	0.707	0.725	0.725	0.714	.	6.060	3.650	2.201	-0.156	-0.133	1.000	0.998	0.993	505	.	.	.	.	OTUD6B	159	0	274	40	0.127388535031847	TRUE	TRUE
ENSG00000164796.18	.	BCM	GRCh38.p13	chr8	112636903	112636903	+	G	G	A	Missense_Mutation	SNP	ENST00000297405.10	exon22	c.C3629T	p.S1210L	exonic	ENSG00000164796.18	.	nonsynonymous SNV	ENSG00000164796.18:ENST00000297405.10:exon22:c.C3629T:p.S1210L	8q23.3	C3N-03426	8.248e-06	0	0	0	0	1.499e-05	0	0	rs749839773	1.20	T	T	B	B	N	N	L	T	N	0.257	T	T	T	0.051	.	0.103	0.140	T	T	T	T	T	T	1.824	17.910	0.993	D	N	-0.513	1.152	-0.361	1.444	0.005	0.487	0.574	0.574	0.564	.	5.740	1.510	1.780	-0.101	0.676	0.744	0.907	0.990	822	Sushi/SCR/CCP_domain	.	.	ID=COSV52105227;OCCURENCE=1(ovary),1(skin)	CSMD3	342	0	583	69	0.105828220858896	TRUE	TRUE
ENSG00000165632.8	.	BCM	GRCh38.p13	chr10	7965242	7965242	+	G	G	A	Missense_Mutation	SNP	ENST00000344293.6	exon3	c.G1732A	p.E578K	exonic	ENSG00000165632.8	.	nonsynonymous SNV	ENSG00000165632.8:ENST00000344293.6:exon3:c.G1732A:p.E578K	10p14	C3N-03426	.	.	.	.	.	.	.	.	.	7.20	D	T	P	B	N	D	M	T	N	0.282	T	T	T	0.082	0.260	0.232	0.248	T	T	T	T	D	D	3.112	23.700	0.997	D	D	0.251	3.536	0.368	4.141	1.000	0.732	0.744	0.653	0.655	.	5.670	5.670	9.169	1.176	0.676	1.000	0.224	0.517	778	.	.	.	.	TAF3	129	0	219	25	0.102459016393443	TRUE	TRUE
ENSG00000148516.21	.	BCM	GRCh38.p13	chr10	31521364	31521364	+	C	C	G	Missense_Mutation	SNP	ENST00000320985.14	exon7	c.C2029G	p.L677V	exonic	ENSG00000148516.21	.	nonsynonymous SNV	ENSG00000148516.21:ENST00000320985.14:exon7:c.C2029G:p.L677V	10p11.22	C3N-03426	8.256e-06	0	0	0	0	0	0	6.06e-05	rs267602469	0.20	T	T	B	B	N	N	L	T	N	0.119	T	T	T	0.049	0.064	0.239	0.145	T	T	T	T	T	T	0.394	5.363	0.591	N	N	-1.138	0.274	-1.119	0.356	0.941	0.707	0.725	0.618	0.714	.	5.340	1.110	1.103	-0.325	-0.224	0.002	0.001	0.854	796	.	.	.	.	ZEB1	385	0	644	70	0.0980392156862745	TRUE	NA
ENSG00000122863.6	.	BCM	GRCh38.p13	chr10	72005902	72005902	+	G	G	C	Missense_Mutation	SNP	ENST00000373115.5	exon2	c.G60C	p.M20I	exonic	ENSG00000122863.6	.	nonsynonymous SNV	ENSG00000122863.6:ENST00000373115.5:exon2:c.G60C:p.M20I	10q22.1	C3N-03426	.	.	.	.	.	.	.	.	.	10.20	T	T	B	B	N	D	N	D	N	0.315	D	D	D	0.359	0.248	0.970	0.721	T	T	D	D	D	T	2.507	22.400	0.990	D	D	-0.097	2.184	0.081	2.657	1.000	0.615	0.547	0.576	0.655	.	5.660	4.730	5.265	0.161	0.676	1.000	0.923	0.966	725	.	.	.	.	CHST3	495	0	693	87	0.111538461538462	TRUE	TRUE
ENSG00000122376.11	.	BCM	GRCh38.p13	chr10	87187153	87187153	+	A	A	C	Missense_Mutation	SNP	ENST00000298784.5	exon8	c.A2261C	p.E754A	exonic	ENSG00000122376.11	.	nonsynonymous SNV	ENSG00000122376.11:ENST00000298784.5:exon8:c.A2261C:p.E754A	10q23.2	C3N-03426	.	.	.	.	.	.	.	.	.	9.19	D	D	D	D	U	D	.	T	D	0.490	T	T	T	0.182	0.353	0.421	1.399	T	T	T	T	D	D	3.987	26.900	0.994	D	N	0.112	2.935	0.098	2.725	0.266	0.737	0.725	0.733	0.728	.	3.130	3.130	5.889	1.298	0.684	1.000	0.993	0.974	919	Protein_FAM35A,_C-terminal_domain	.	.	.	SHLD2	171	0	272	24	0.0810810810810811	NA	TRUE
ENSG00000121236.21	.	BCM	GRCh38.p13	chr11	5605503	5605503	+	C	C	T	Missense_Mutation	SNP	ENST00000278302.9	exon4	c.C686T	p.S229L	exonic	ENSG00000121236.21;ENSG00000258588.3	.	nonsynonymous SNV	ENSG00000121236.21:ENST00000278302.9:exon4:c.C686T:p.S229L,ENSG00000258588.3:ENST00000354852.5:exon4:c.C770T:p.S257L	11p15.4	C3N-03426	2.474e-05	0	0	0	0	3e-05	0	6.062e-05	rs751430177	0.19	T	T	P	B	.	N	N	T	N	0.296	T	T	T	0.066	0.354	0.216	0.039	T	T	T	T	T	T	1.035	12.060	0.810	N	N	-0.740	0.746	-0.775	0.793	1.000	0.707	0.670	0.725	0.655	.	4.850	2.910	0.132	1.026	0.599	0.000	0.326	0.618	814	.	.	.	ID=COSV53479532;OCCURENCE=1(oesophagus),1(large_intestine)	TRIM6	323	0	489	56	0.102752293577982	TRUE	TRUE
ENSG00000166311.10	.	BCM	GRCh38.p13	chr11	6391901	6391901	+	G	G	A	Missense_Mutation	SNP	ENST00000342245.9	exon2	c.G836A	p.G279E	exonic	ENSG00000166311.10	.	nonsynonymous SNV	ENSG00000166311.10:ENST00000342245.9:exon2:c.G836A:p.G279E	11p15.4	C3N-03426	.	.	.	.	.	.	.	.	rs727504168	17.17	D	D	.	.	D	D	.	D	D	0.936	D	D	D	0.979	.	0.991	0.920	D	D	D	D	D	D	4.036	27.200	0.998	D	D	1.038	15.154	0.936	15.389	1.000	0.732	0.744	0.616	0.714	.	5.130	5.130	9.346	1.079	0.676	1.000	0.998	0.990	804	Calcineurin-like_phosphoesterase_domain,_ApaH_type	.	.	.	SMPD1	220	0	327	46	0.123324396782842	TRUE	NA
ENSG00000166833.21	.	BCM	GRCh38.p13	chr11	20068336	20068336	+	C	C	T	Missense_Mutation	SNP	ENST00000396087.7	exon24	c.C5089T	p.R1697W	exonic	ENSG00000166833.21	.	nonsynonymous SNV	ENSG00000166833.21:ENST00000396087.7:exon24:c.C5089T:p.R1697W	11p15.1	C3N-03426	1.648e-05	0	8.658e-05	0	0	0	0	6.058e-05	rs151080998	20.20	D	D	D	D	D	D	M	D	D	0.831	D	D	D	0.638	0.446	0.973	1.274	D	D	D	D	D	D	3.744	25.600	0.999	D	D	0.115	2.944	0.011	2.396	0.772	0.707	0.588	0.725	0.714	.	5.420	0.330	1.411	0.074	0.599	0.847	0.998	0.994	840	.	.	.	ID=COSV100216568;OCCURENCE=3(central_nervous_system),1(endometrium)	NAV2	259	0	422	44	0.0944206008583691	TRUE	NA
ENSG00000109881.17	.	BCM	GRCh38.p13	chr11	27357403	27357403	+	C	C	G	Missense_Mutation	SNP	ENST00000328697.11	exon2	c.G498C	p.E166D	exonic	ENSG00000109881.17	.	nonsynonymous SNV	ENSG00000109881.17:ENST00000328697.11:exon2:c.G498C:p.E166D	11p14.1	C3N-03426	.	.	.	.	.	.	.	.	.	12.20	D	D	D	D	D	D	M	T	D	0.397	T	T	D	0.186	0.167	0.741	0.579	T	T	T	T	D	T	5.998	35	0.999	D	D	0.695	7.046	0.695	7.655	1.000	0.706	0.634	0.710	0.668	.	5.610	5.610	4.573	1.026	0.599	1.000	0.996	0.970	563	.	.	.	.	CCDC34	108	0	204	25	0.109170305676856	TRUE	NA
ENSG00000173120.15	.	BCM	GRCh38.p13	chr11	67245216	67245216	+	C	C	T	Missense_Mutation	SNP	ENST00000529006.7	exon14	c.C1591T	p.R531W	exonic	ENSG00000173120.15	.	nonsynonymous SNV	ENSG00000173120.15:ENST00000529006.7:exon14:c.C1591T:p.R531W	11q13.2	C3N-03426	.	.	.	.	.	.	.	.	.	9.20	D	D	D	P	N	D	L	T	N	0.375	T	T	D	0.110	0.440	0.182	1.768	T	T	T	T	D	D	3.833	26.000	0.999	D	D	0.249	3.529	0.296	3.695	1.000	0.672	0.698	0.702	0.711	.	5.360	4.430	2.652	0.074	0.599	1.000	0.992	0.986	253	.	.	.	.	KDM2A	178	0	276	47	0.145510835913313	TRUE	TRUE
ENSG00000023445.16	.	BCM	GRCh38.p13	chr11	102324951	102324951	+	T	T	A	Missense_Mutation	SNP	ENST00000263464.9	exon2	c.T442A	p.S148T	exonic	ENSG00000023445.16	.	nonsynonymous SNV	ENSG00000023445.16:ENST00000263464.9:exon2:c.T442A:p.S148T	11q22.2	C3N-03426	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.074	T	T	T	0.065	0.248	0.363	0.250	T	T	T	T	T	T	0.783	9.223	0.071	N	N	-0.898	0.523	-0.868	0.663	1.000	0.638	0.686	0.574	0.668	.	5.400	4.250	0.891	1.043	0.609	0.001	0.019	0.087	740	.	.	.	.	BIRC3	202	0	339	47	0.121761658031088	TRUE	TRUE
ENSG00000182634.8	.	BCM	GRCh38.p13	chr11	124038589	124038589	+	C	C	T	Missense_Mutation	SNP	ENST00000641585.1	exon2	c.G413A	p.R138H	exonic	ENSG00000182634.8	.	nonsynonymous SNV	ENSG00000182634.8:ENST00000641585.1:exon2:c.G413A:p.R138H	11q24.2	C3N-03426	0.0008	0.0068	0.0022	0	0	1.498e-05	0	0	rs146405371	4.20	D	T	P	P	N	N	M	T	D	0.299	T	T	D	0.330	.	0.886	1.232	T	T	T	T	T	T	1.740	17.300	0.998	N	N	-0.334	1.532	-0.585	1.070	0.000	0.487	0.574	0.574	0.564	.	3.240	1.330	-2.323	0.097	0.577	0.000	0.000	0.001	792	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV57869403;OCCURENCE=1(oesophagus),1(endometrium)	OR10G7	334	0	526	65	0.109983079526227	NA	TRUE
ENSG00000161850.3	.	BCM	GRCh38.p13	chr12	52396963	52396963	+	G	G	A	Missense_Mutation	SNP	ENST00000257974.3	exon6	c.C988T	p.R330C	exonic	ENSG00000161850.3	.	nonsynonymous SNV	ENSG00000161850.3:ENST00000257974.3:exon6:c.C988T:p.R330C	12q13.13	C3N-03426	0.0010	0.0017	0.0002	0	0.0002	0.0011	0.0022	0.0012	rs139209735	12.20	D	D	B	B	D	D	M	D	D	0.297	D	D	D	0.460	.	0.768	0.083	T	D	T	T	T	D	3.127	23.700	0.998	N	N	-0.039	2.374	-0.020	2.292	0.275	0.497	0.590	0.547	0.542	.	5.140	4.250	1.335	1.176	0.676	0.012	0.995	0.993	778	Intermediate_filament,_rod_domain	.	.	ID=COSV57786220;OCCURENCE=1(skin)	KRT82	241	0	355	32	0.082687338501292	TRUE	TRUE
ENSG00000183495.14	.	BCM	GRCh38.p13	chr12	132025765	132025765	+	C	C	G	Missense_Mutation	SNP	ENST00000389561.7	exon25	c.C4975G	p.P1659A	exonic	ENSG00000183495.14	.	nonsynonymous SNV	ENSG00000183495.14:ENST00000389561.7:exon25:c.C4975G:p.P1659A	12q24.33	C3N-03426	.	.	.	.	.	.	.	.	.	4.18	T	T	B	B	N	N	.	D	N	0.299	T	D	D	0.272	.	0.349	0.435	T	.	T	T	T	T	1.610	16.440	0.708	D	N	-0.553	1.075	-0.410	1.355	0.928	0.707	0.702	0.725	0.636	.	5.280	4.390	2.725	0.127	-0.193	0.963	0.373	0.150	970	.	.	.	.	EP400	100	0	176	29	0.141463414634146	TRUE	TRUE
ENSG00000136111.14	.	BCM	GRCh38.p13	chr13	75306460	75306460	+	C	C	A	Nonsense_Mutation	SNP	ENST00000377636.8	exon15	c.G2605T	p.E869X	exonic	ENSG00000136111.14	.	stopgain	ENSG00000136111.14:ENST00000377636.8:exon15:c.G2605T:p.E869X	13q22.2	C3N-03426	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	D	D	.	.	.	0.980	.	.	.	.	.	.	.	.	.	D	D	.	.	8.869	46	0.997	D	N	1.200	23.709	1.072	24.155	1.000	0.661	0.644	0.659	0.646	.	5.910	5.910	6.919	1.026	0.599	1.000	1.000	0.997	967	.	.	.	.	TBC1D4	156	1	264	23	0.0801393728222996	TRUE	TRUE
ENSG00000152192.8	.	BCM	GRCh38.p13	chr13	78601549	78601549	+	C	C	T	Missense_Mutation	SNP	ENST00000377208.7	exon2	c.G1126A	p.V376M	exonic	ENSG00000152192.8	.	nonsynonymous SNV	ENSG00000152192.8:ENST00000377208.7:exon2:c.G1126A:p.V376M	13q31.1	C3N-03426	.	.	.	.	.	.	.	.	.	16.20	D	T	D	D	U	D	N	D	N	0.455	D	D	D	0.548	0.349	0.824	.	D	D	D	D	D	D	3.505	24.700	0.994	D	D	0.462	4.756	0.446	4.699	1.000	0.443	0.541	0.666	0.568	.	4.350	4.350	6.020	1.006	0.576	1.000	0.027	0.140	638	Homeobox_domain	.	.	.	POU4F1	393	0	529	58	0.0988074957410562	TRUE	TRUE
ENSG00000100731.16	.	BCM	GRCh38.p13	chr14	71013183	71013183	+	C	C	T	Missense_Mutation	SNP	ENST00000304743.7	exon11	c.C2977T	p.L993F	exonic	ENSG00000100731.16	.	nonsynonymous SNV	ENSG00000100731.16:ENST00000304743.7:exon11:c.C2977T:p.L993F	14q24.2	C3N-03426	.	.	.	.	.	.	.	.	.	16.20	D	T	D	D	D	D	M	T	D	0.880	D	D	D	0.742	0.663	0.410	0.545	T	T	D	D	D	D	3.891	26.300	0.999	D	D	0.794	8.666	0.780	9.555	1.000	0.707	0.725	0.725	0.714	.	5.350	5.350	7.284	1.026	0.599	1.000	1.000	1.000	776	.	.	.	.	PCNX1	512	0	772	92	0.106481481481481	TRUE	TRUE
ENSG00000181827.15	.	BCM	GRCh38.p13	chr15	56093484	56093484	+	T	T	C	Missense_Mutation	SNP	ENST00000674082.1	exon12	c.A3953G	p.D1318G	exonic	ENSG00000181827.15	.	nonsynonymous SNV	ENSG00000181827.15:ENST00000674082.1:exon12:c.A3953G:p.D1318G	15q21.3	C3N-03426	.	.	.	.	.	.	.	.	.	6.20	T	T	D	P	U	D	L	T	N	0.600	T	T	T	0.204	0.125	0.123	.	T	T	T	T	D	D	3.370	24.300	0.992	D	D	0.487	4.934	0.569	5.862	1.000	0.707	0.725	0.702	0.714	.	5.870	5.870	5.808	1.138	0.665	1.000	1.000	1.000	819	.	.	.	.	RFX7	145	0	256	25	0.0889679715302491	TRUE	TRUE
ENSG00000172349.17	.	BCM	GRCh38.p13	chr15	81282647	81282647	+	G	G	A	Missense_Mutation	SNP	ENST00000302987.8	exon8	c.G1090A	p.V364M	exonic	ENSG00000172349.17	.	nonsynonymous SNV	ENSG00000172349.17:ENST00000302987.8:exon8:c.G1090A:p.V364M	15q25.1	C3N-03426	8.292e-06	0	0	0	0	1.501e-05	0	0	rs770332586	11.20	D	D	D	D	N	D	L	T	D	0.615	T	T	D	0.303	0.386	0.427	0.537	T	T	T	T	D	D	3.444	24.500	0.998	D	D	0.617	6.096	0.535	5.495	1.000	0.487	0.547	0.574	0.542	.	5.460	5.460	8.557	1.120	0.618	1.000	0.843	0.202	803	PDZ_domain	.	.	.	IL16	132	0	214	30	0.122950819672131	TRUE	NA
ENSG00000176046.9	.	BCM	GRCh38.p13	chr16	28538043	28538043	+	C	C	A	Missense_Mutation	SNP	ENST00000324873.8	exon2	c.G225T	p.R75S	exonic	ENSG00000176046.9	.	nonsynonymous SNV	ENSG00000176046.9:ENST00000324873.8:exon2:c.G225T:p.R75S	16p11.2	C3N-03426	.	.	.	.	.	.	.	.	.	3.18	T	T	B	B	N	D	.	.	N	0.274	T	T	T	0.044	0.400	0.175	0.215	T	T	T	T	D	T	2.414	22.100	0.986	N	D	-0.438	1.303	-0.349	1.467	1.000	0.624	0.588	0.547	0.580	.	5.400	2.240	0.112	0.129	-0.182	0.601	0.862	0.989	688	.	.	.	.	NUPR1	75	0	118	14	0.106060606060606	TRUE	TRUE
ENSG00000167693.17	.	BCM	GRCh38.p13	chr17	805107	805107	+	C	C	T	Missense_Mutation	SNP	ENST00000336868.8	exon6	c.G961A	p.A321T	exonic	ENSG00000167693.17	.	nonsynonymous SNV	ENSG00000167693.17:ENST00000336868.8:exon6:c.G961A:p.A321T	17p13.3	C3N-03426	5.514e-05	0.0003	0	0	0	2.538e-05	0	8.585e-05	rs200704586	2.20	T	T	B	B	N	D	N	T	N	0.257	T	T	T	0.074	.	0.093	0.661	T	T	T	T	T	T	1.065	12.400	0.915	D	N	-0.899	0.521	-0.726	0.862	0.777	0.696	0.588	0.723	0.563	.	5.170	3.180	4.997	-0.232	-0.891	1.000	0.733	0.234	951	Thioredoxin_domain	.	.	.	NXN	483	0	612	89	0.126961483594864	TRUE	NA
ENSG00000070366.14	.	BCM	GRCh38.p13	chr17	2299612	2299612	+	C	C	T	Missense_Mutation	SNP	ENST00000263073.11	exon2	c.G1141A	p.G381S	exonic	ENSG00000070366.14	.	nonsynonymous SNV	ENSG00000070366.14:ENST00000263073.11:exon2:c.G1141A:p.G381S	17p13.3	C3N-03426	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.126	T	T	T	0.058	0.231	0.235	0.162	T	T	T	T	T	T	0.164	2.724	0.872	N	N	-1.084	0.321	-1.067	0.410	0.400	0.719	0.698	0.723	0.711	.	5.350	-0.246	0.224	-0.996	-0.176	0.000	0.104	0.230	652	.	.	.	.	SMG6	186	0	235	41	0.148550724637681	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674250	7674250	+	C	C	T	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.G713A	p.C238Y	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.G713A:p.C238Y	17p13.1	C3N-03426	1.648e-05	0	0	0	0	2.997e-05	0	0	rs730882005	20.20	D	D	D	D	D	D	M	D	D	0.978	D	D	D	0.957	0.989	0.993	0.492	D	D	D	D	D	D	4.116	27.900	0.997	D	D	0.869	10.286	0.765	9.165	1.000	0.722	0.702	0.725	0.735	.	4.090	4.090	7.829	1.021	0.596	1.000	1.000	1.000	433	p53,_DNA-binding_domain	.	.	ID=COSV52661646;OCCURENCE=1(salivary_gland),25(breast),1(liver),16(oesophagus),19(large_intestine),10(central_nervous_system),3(biliary_tract),13(ovary),1(bone),5(stomach),20(haematopoietic_and_lymphoid_tissue),3(urinary_tract),9(soft_tissue),14(pancreas),2(skin),3(prostate),5(lung),2(thyroid),4(upper_aerodigestive_tract),5(endometrium)	TP53	349	0	463	67	0.126415094339623	TRUE	TRUE
ENSG00000184650.11	.	BCM	GRCh38.p13	chr17	8340394	8340394	+	C	C	T	Missense_Mutation	SNP	ENST00000328248.7	exon1	c.C343T	p.R115C	exonic	ENSG00000184650.11	.	nonsynonymous SNV	ENSG00000184650.11:ENST00000328248.7:exon1:c.C343T:p.R115C	17p13.1	C3N-03426	5.923e-05	0	0	0.0008	0	0	0	0	rs557908400	7.20	D	D	D	D	N	D	M	T	D	0.400	T	T	T	0.173	0.470	0.390	0.830	T	T	T	T	T	T	3.055	23.500	0.999	N	N	0.258	3.571	0.164	3.014	0.000	0.554	0.547	0.602	0.613	.	4.590	3.620	0.632	1.026	0.599	0.767	0.621	0.520	286	.	.	.	.	ODF4	445	1	625	78	0.110953058321479	TRUE	NA
ENSG00000125414.19	.	BCM	GRCh38.p13	chr17	10547838	10547838	+	T	T	C	Missense_Mutation	SNP	ENST00000245503.10	exon3	c.A83G	p.Q28R	exonic	ENSG00000125414.19	.	nonsynonymous SNV	ENSG00000125414.19:ENST00000245503.10:exon3:c.A83G:p.Q28R	17p13.1	C3N-03426	.	.	.	.	.	.	.	.	.	16.20	D	T	D	D	U	D	M	D	D	0.696	D	D	D	0.718	0.473	0.891	1.469	T	T	D	D	D	D	3.274	24.100	0.998	D	D	0.669	6.706	0.656	7.003	1.000	0.615	0.574	0.659	0.564	.	5.670	5.670	4.158	1.049	0.665	1.000	1.000	1.000	356	.	.	.	.	MYH2	455	1	516	77	0.129848229342327	TRUE	TRUE
ENSG00000161395.14	.	BCM	GRCh38.p13	chr17	39672859	39672859	+	C	C	T	Missense_Mutation	SNP	ENST00000300658.9	exon8	c.G907A	p.E303K	exonic	ENSG00000161395.14	.	nonsynonymous SNV	ENSG00000161395.14:ENST00000300658.9:exon8:c.G907A:p.E303K	17q12	C3N-03426	.	.	.	.	.	.	.	.	.	3.19	T	T	B	B	N	D	N	.	N	0.241	T	T	T	0.037	0.480	0.126	0.354	T	T	T	T	T	D	2.165	20.600	0.832	D	N	-0.913	0.505	-0.705	0.893	1.000	0.706	0.644	0.710	0.700	.	5.330	0.363	0.785	0.129	-0.182	1.000	0.999	0.995	583	.	.	.	ID=COSV99510679;OCCURENCE=1(ovary)	PGAP3	260	0	2146	308	0.125509372453138	TRUE	TRUE
ENSG00000109062.12	.	BCM	GRCh38.p13	chr17	74763406	74763406	+	G	G	A	Missense_Mutation	SNP	ENST00000262613.10	exon3	c.G643A	p.V215M	exonic	ENSG00000109062.12	.	nonsynonymous SNV	ENSG00000109062.12:ENST00000262613.10:exon3:c.G643A:p.V215M	17q25.1	C3N-03426	8.423e-05	0	0	0	0.0005	0.0001	0	0	rs766649573	12.20	D	D	D	D	D	D	M	T	D	0.912	T	T	D	0.576	0.798	0.726	0.338	T	T	T	D	T	T	4.213	28.800	0.999	D	D	0.860	10.058	0.838	11.343	1.000	0.706	0.725	0.688	0.613	.	5.450	5.450	9.602	1.176	0.618	1.000	0.968	0.884	707	PDZ_domain	.	.	.	SLC9A3R1	86	0	163	18	0.0994475138121547	TRUE	NA
ENSG00000101680.15	.	BCM	GRCh38.p13	chr18	7035998	7035998	+	C	C	T	Missense_Mutation	SNP	ENST00000389658.4	exon13	c.G1828A	p.V610I	exonic	ENSG00000101680.15	.	nonsynonymous SNV	ENSG00000101680.15:ENST00000389658.4:exon13:c.G1828A:p.V610I	18p11.31	C3N-03426	3.302e-05	0	0	0	0	0	0	0.0002	rs528185369	2.20	T	T	P	B	N	D	L	T	N	0.387	T	T	T	0.128	0.810	0.193	0.229	T	T	T	T	T	T	1.176	13.450	0.919	D	N	-0.529	1.120	-0.558	1.109	1.000	0.732	0.563	0.744	0.613	.	5.780	2.020	2.366	-0.213	-0.176	0.971	0.147	0.198	889	Laminin_IV	.	.	ID=COSV67532208;OCCURENCE=1(oesophagus),2(pancreas)	LAMA1	338	0	468	102	0.178947368421053	TRUE	TRUE
ENSG00000141646.14	.	BCM	GRCh38.p13	chr18	51067108	51067109	+	AG	AG	-	Frame_Shift_Del	DEL	ENST00000342988.8	exon10	c.1229_1230del	p.S411Lfs*17	exonic	ENSG00000141646.14	.	frameshift deletion	ENSG00000141646.14:ENST00000342988.8:exon10:c.1229_1230del:p.S411Lfs*17	18q21.2	C3N-03426	.	.	.	.	.	.	.	.	rs730881952	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMAD4	259	0	375	43	0.102870813397129	TRUE	NA
ENSG00000196757.8	.	BCM	GRCh38.p13	chr19	11949498	11949498	+	C	C	G	Missense_Mutation	SNP	ENST00000254321.10	exon4	c.C1474G	p.H492D	exonic	ENSG00000196757.8	.	nonsynonymous SNV	ENSG00000196757.8:ENST00000254321.10:exon4:c.C1474G:p.H492D	19p13.2	C3N-03426	.	.	.	.	.	.	.	.	.	11.19	D	D	P	P	.	D	M	D	D	0.407	D	D	D	0.526	0.891	0.864	0.012	T	T	D	D	T	T	1.524	15.890	0.770	N	N	-0.602	0.985	-0.898	0.623	0.004	0.672	0.698	0.702	0.636	.	0.149	0.149	0.620	0.238	0.219	0.002	0.007	0.009	934	Zinc_finger_C2H2-type	.	.	.	ZNF700	297	0	487	109	0.182885906040268	TRUE	TRUE
ENSG00000172519.9	.	BCM	GRCh38.p13	chr19	15794100	15794100	+	T	T	A	Missense_Mutation	SNP	ENST00000642092.1	exon2	c.T52A	p.S18T	exonic	ENSG00000172519.9	.	nonsynonymous SNV	ENSG00000172519.9:ENST00000642092.1:exon2:c.T52A:p.S18T	19p13.12	C3N-03426	.	.	.	.	.	.	.	.	.	6.20	D	T	D	D	D	N	L	T	D	0.099	T	T	T	0.069	0.424	0.411	0.378	T	T	T	T	D	T	2.192	20.800	0.986	N	N	-0.008	2.484	-0.167	1.866	0.000	0.487	0.574	0.574	0.564	.	3.450	3.450	-0.591	0.812	0.637	0.000	0.039	0.024	976	.	.	.	.	OR10H5	141	1	251	24	0.0872727272727273	NA	TRUE
ENSG00000130479.11	.	BCM	GRCh38.p13	chr19	17727810	17727810	+	C	C	T	Missense_Mutation	SNP	ENST00000324096.9	exon5	c.C2426T	p.S809L	exonic	ENSG00000130479.11	.	nonsynonymous SNV	ENSG00000130479.11:ENST00000324096.9:exon5:c.C2426T:p.S809L	19p13.11	C3N-03426	.	.	.	.	.	.	.	.	.	7.20	T	T	B	B	D	N	M	T	D	0.508	T	T	T	0.138	0.351	0.247	0.910	T	T	T	T	D	D	2.570	22.600	0.995	D	D	-0.669	0.865	-0.643	0.982	0.124	0.707	0.702	0.723	0.714	.	4.670	2.510	5.646	0.877	-0.202	0.979	0.006	0.001	964	.	.	.	.	MAP1S	112	0	194	29	0.130044843049327	TRUE	TRUE
ENSG00000090372.15	.	BCM	GRCh38.p13	chr19	46730842	46730842	+	-	NA	GC	Frame_Shift_Ins	INS	ENST00000263280.11	exon6	c.768_769insGC	p.L257Afs*37	exonic	ENSG00000090372.15	.	frameshift insertion	ENSG00000090372.15:ENST00000263280.11:exon6:c.768_769insGC:p.L257Afs*37	19q13.32	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	STRN4	NA	NA	NA	NA	NA	NA	NA
ENSG00000142405.22	.	BCM	GRCh38.p13	chr19	53810061	53810061	+	C	C	T	Missense_Mutation	SNP	ENST00000324134.11	exon3	c.G1598A	p.G533D	exonic	ENSG00000142405.22	.	nonsynonymous SNV	ENSG00000142405.22:ENST00000324134.11:exon3:c.G1598A:p.G533D	19q13.42	C3N-03426	.	.	.	.	.	.	.	.	.	1.20	T	T	B	B	U	N	N	D	N	0.124	T	T	T	0.097	0.374	0.478	0.066	T	T	T	T	T	T	-0.906	0.014	0.615	N	N	-1.440	0.101	-1.480	0.115	0.856	0.534	0.574	0.686	0.662	.	4.430	-2.420	-1.957	-0.312	-0.983	0.000	0.000	0.000	994	.	.	.	.	NLRP12	467	0	667	100	0.130378096479791	TRUE	TRUE
ENSG00000131864.10	.	BCM	GRCh38.p13	chr19	57131436	57131436	+	C	C	T	Missense_Mutation	SNP	ENST00000254181.8	exon4	c.C2761T	p.P921S	exonic	ENSG00000131864.10	.	nonsynonymous SNV	ENSG00000131864.10:ENST00000254181.8:exon4:c.C2761T:p.P921S	19q13.43	C3N-03426	.	.	.	.	.	.	.	.	.	1.18	D	.	B	B	.	N	N	T	N	0.094	T	T	T	0.009	0.236	0.174	0.026	T	T	T	T	T	T	-0.154	0.639	0.629	N	N	-2.072	0.006	-2.186	0.005	0.416	0.487	0.574	0.574	0.564	.	1.570	-3.130	-2.009	-2.101	-1.114	0.000	0.000	0.006	958	.	.	.	.	USP29	44	0	99	10	0.0917431192660551	TRUE	TRUE
ENSG00000101292.7	.	BCM	GRCh38.p13	chr20	5302110	5302110	+	C	C	G	Missense_Mutation	SNP	ENST00000217270.3	exon2	c.G1085C	p.S362T	exonic	ENSG00000101292.7	.	nonsynonymous SNV	ENSG00000101292.7:ENST00000217270.3:exon2:c.G1085C:p.S362T	20p12.3	C3N-03426	.	.	.	.	.	.	.	.	.	4.20	T	T	B	B	D	D	M	T	N	0.122	T	T	T	0.093	0.175	0.678	.	T	T	T	T	T	T	1.655	16.730	0.839	D	N	-0.111	2.139	0.011	2.398	0.004	0.638	0.574	0.653	0.530	.	5.200	5.200	2.189	1.022	0.596	0.944	0.972	0.317	952	.	.	.	.	PROKR2	187	0	277	41	0.128930817610063	TRUE	TRUE
ENSG00000214078.12	.	BCM	GRCh38.p13	chr20	35632626	35632626	+	C	C	A	Missense_Mutation	SNP	ENST00000352393.8	exon5	c.G200T	p.R67L	exonic	ENSG00000214078.12	.	nonsynonymous SNV	ENSG00000214078.12:ENST00000352393.8:exon5:c.G200T:p.R67L	20q11.22	C3N-03426	8.237e-05	9.61e-05	0	0.0010	0	0	0	0	rs142217317	4.20	D	T	B	B	U	N	N	T	N	0.334	T	T	T	0.171	.	0.562	0.247	T	T	T	T	T	D	3.527	24.800	0.994	D	D	-0.371	1.448	-0.177	1.841	1.000	0.707	0.725	0.725	0.714	.	5.250	4.150	5.158	0.204	-0.114	1.000	0.998	0.991	362	C2_domain	.	.	.	CPNE1	247	1	407	37	0.0833333333333333	TRUE	TRUE
ENSG00000101158.15	.	BCM	GRCh38.p13	chr20	58994204	58994204	+	C	C	T	Missense_Mutation	SNP	ENST00000652272.2	exon14	c.C1676T	p.T559M	exonic	ENSG00000101158.15	.	nonsynonymous SNV	ENSG00000101158.15:ENST00000652272.2:exon14:c.C1676T:p.T559M	20q13.32	C3N-03426	8.248e-06	9.645e-05	0	0	0	0	0	0	rs760408804	7.13	.	D	.	.	D	D	.	.	.	0.457	T	T	T	0.135	.	0.422	0.720	T	.	T	T	D	D	2.443	22.300	0.999	D	D	0.271	3.633	0.261	3.498	1.000	0.722	0.699	0.702	0.711	.	4.590	3.620	5.671	1.022	0.596	0.997	0.888	0.708	987	.	.	.	.	NELFCD	101	0	178	25	0.123152709359606	TRUE	NA
ENSG00000243509.6	.	BCM	GRCh38.p13	chr20	63696933	63696933	+	A	A	G	Missense_Mutation	SNP	ENST00000369996.3	exon1	c.A166G	p.T56A	exonic	ENSG00000243509.6	.	nonsynonymous SNV	ENSG00000243509.6:ENST00000369996.3:exon1:c.A166G:p.T56A	20q13.33	C3N-03426	.	.	.	.	.	.	.	.	.	8.19	D	T	P	B	.	N	M	T	D	0.391	T	T	D	0.471	0.324	0.578	0.104	T	D	T	T	D	T	3.011	23.400	0.994	D	D	0.197	3.289	0.183	3.100	1.000	0.652	0.611	0.641	0.581	.	3.890	3.890	4.089	1.118	0.756	0.997	0.136	0.419	.	Tumor_necrosis_factor_receptor_6B,_N-terminal;TNFR/NGFR_cysteine-rich_region	.	.	.	TNFRSF6B	230	0	265	29	0.0986394557823129	TRUE	TRUE
ENSG00000101958.14	.	BCM	GRCh38.p13	chrX	14730231	14730231	+	C	C	T	Missense_Mutation	SNP	ENST00000218075.9	exon9	c.C1105T	p.R369C	exonic	ENSG00000101958.14	.	nonsynonymous SNV	ENSG00000101958.14:ENST00000218075.9:exon9:c.C1105T:p.R369C	Xp22.2	C3N-03426	.	.	.	.	.	.	.	.	.	18.19	D	D	D	D	D	D	L	D	D	0.544	D	D	D	0.652	0.590	0.905	2.624	D	D	D	D	D	D	3.891	26.300	0.999	D	.	.	.	.	.	1.000	.	.	.	.	.	5.200	5.200	4.879	1.026	0.549	1.000	1.000	0.994	146	.	.	.	.	GLRA2	213	0	309	35	0.101744186046512	TRUE	NA
ENSG00000101892.12	.	BCM	GRCh38.p13	chrX	120366635	120366635	+	G	G	T	Missense_Mutation	SNP	ENST00000218008.8	exon2	c.G174T	p.E58D	exonic	ENSG00000101892.12	.	nonsynonymous SNV	ENSG00000101892.12:ENST00000218008.8:exon2:c.G174T:p.E58D	Xq24	C3N-03426	.	.	.	.	.	.	.	.	.	2.19	T	D	B	B	N	N	N	T	N	0.190	T	T	T	0.039	0.096	0.432	0.141	T	T	T	T	T	T	0.261	3.838	0.988	D	.	.	.	.	.	1.000	.	.	.	.	.	4.310	0.493	0.181	0.206	-0.166	0.157	0.852	0.076	924	.	.	.	.	ATP1B4	376	0	521	69	0.116949152542373	TRUE	TRUE
ENSG00000169551.12	.	BCM	GRCh38.p13	chrX	135169755	135169755	+	G	G	A	Nonsense_Mutation	SNP	ENST00000276241.10	exon2	c.C118T	p.Q40X	exonic	ENSG00000169551.12	.	stopgain	ENSG00000169551.12:ENST00000276241.10:exon2:c.C118T:p.Q40X	Xq26.3	C3N-03426	.	.	.	.	.	.	.	.	.	2.5	.	.	.	.	N	A	.	.	.	0.118	.	.	.	.	.	.	.	.	.	D	T	.	.	3.931	26.500	0.993	N	.	.	.	.	.	0.125	.	.	.	.	.	2.610	0.599	1.038	1.043	0.575	0.566	0.014	0.195	512	S1-like_RNA_binding_domain	.	.	.	CT55	80	0	148	20	0.119047619047619	NA	TRUE
ENSG00000102245.8	.	BCM	GRCh38.p13	chrX	136648280	136648280	+	G	G	A	Missense_Mutation	SNP	ENST00000370629.7	exon1	c.G32A	p.R11Q	exonic	ENSG00000102245.8	.	nonsynonymous SNV	ENSG00000102245.8:ENST00000370629.7:exon1:c.G32A:p.R11Q	Xq26.3	C3N-03426	0.0001	0.0001	0.0001	0	0	0.0002	0	0	rs145115086	5.19	D	T	D	P	N	N	L	T	N	0.189	T	T	D	0.297	.	0.785	1.335	T	D	T	T	T	D	2.684	22.800	0.999	N	.	.	.	.	.	0.944	.	.	.	.	.	5.800	3.940	4.201	1.176	0.674	0.622	0.994	0.904	155	.	.	.	ID=COSV65698277;OCCURENCE=1(large_intestine),1(skin)	CD40LG	309	0	490	58	0.105839416058394	TRUE	TRUE
ENSG00000154027.19	.	BCM	GRCh38.p13	chr1	77293961	77293961	+	G	G	T	Splice_Site	SNP	NA	NA	NA	NA	splicing	ENSG00000154027.19	ENST00000354567.7:exon3:c.415+1G>T	.	.	1p31.1	C3N-03426	.	.	.	.	.	.	.	.	.	4.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	D	D	.	.	5.845	35	0.995	D	.	1.164	20.895	0.998	18.706	1.000	0.075	0.063	0.079	0.102	0.972	5.130	5.130	9.532	1.176	0.676	1.000	1.000	0.948	835	.	.	.	.	AK5	159	0	298	21	0.0658307210031348	TRUE	TRUE
ENSG00000117114.20	.	BCM	GRCh38.p13	chr1	81966408	81966408	+	T	T	A	Silent	SNP	ENST00000370728.5	exon15	c.T2136A	p.L712L	exonic	ENSG00000117114.20	.	synonymous SNV	ENSG00000117114.20:ENST00000370728.5:exon15:c.T2136A:p.L712L	1p31.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ADGRL2	162	0	221	60	0.213523131672598	TRUE	TRUE
ENSG00000143376.14	.	BCM	GRCh38.p13	chr1	151638960	151638960	+	G	G	A	Silent	SNP	ENST00000458013.7	exon2	c.G384A	p.L128L	exonic	ENSG00000143376.14	.	synonymous SNV	ENSG00000143376.14:ENST00000458013.7:exon2:c.G384A:p.L128L	1q21.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SNX27	354	0	591	56	0.0865533230293663	TRUE	TRUE
ENSG00000067704.10	.	BCM	GRCh38.p13	chr1	220103468	220103468	+	T	T	G	Silent	SNP	ENST00000366922.3	exon8	c.T972G	p.S324S	exonic	ENSG00000067704.10	.	synonymous SNV	ENSG00000067704.10:ENST00000366922.3:exon8:c.T972G:p.S324S	1q41	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	IARS2	109	0	180	26	0.12621359223301	TRUE	TRUE
ENSG00000138079.14	.	BCM	GRCh38.p13	chr2	44320363	44320363	+	C	C	T	Silent	SNP	ENST00000260649.11	exon10	c.C1782T	p.I594I	exonic	ENSG00000138079.14	.	synonymous SNV	ENSG00000138079.14:ENST00000260649.11:exon10:c.C1782T:p.I594I	2p21	C3N-03426	3.296e-05	0	0	0	0	5.996e-05	0	0	rs373561366	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC3A1	239	0	368	40	0.0980392156862745	TRUE	NA
ENSG00000163645.15	.	BCM	GRCh38.p13	chr3	150660075	150660075	+	G	G	T	Silent	SNP	ENST00000295910.11	exon14	c.C1809A	p.I603I	exonic	ENSG00000163645.15	.	synonymous SNV	ENSG00000163645.15:ENST00000295910.11:exon14:c.C1809A:p.I603I	3q25.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ERICH6	217	0	322	29	0.0826210826210826	TRUE	TRUE
ENSG00000153147.6	.	BCM	GRCh38.p13	chr4	143553160	143553160	+	A	A	G	Silent	SNP	ENST00000283131.4	exon24	c.A3135G	p.G1045G	exonic	ENSG00000153147.6	.	synonymous SNV	ENSG00000153147.6:ENST00000283131.4:exon24:c.A3135G:p.G1045G	4q31.21	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SMARCA5	201	0	358	56	0.135265700483092	TRUE	TRUE
ENSG00000165097.16	.	BCM	GRCh38.p13	chr6	18221911	18221911	+	A	A	C	Silent	SNP	ENST00000650836.2	exon22	c.A2388C	p.A796A	exonic	ENSG00000165097.16	.	synonymous SNV	ENSG00000165097.16:ENST00000650836.2:exon22:c.A2388C:p.A796A	6p22.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	KDM1B	42	0	84	16	0.16	TRUE	TRUE
ENSG00000122507.21	.	BCM	GRCh38.p13	chr7	33273942	33273942	+	A	A	G	Silent	SNP	ENST00000242067.11	exon9	c.A1002G	p.R334R	exonic	ENSG00000122507.21	.	synonymous SNV	ENSG00000122507.21:ENST00000242067.11:exon9:c.A1002G:p.R334R	7p14.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BBS9	301	0	445	117	0.208185053380783	TRUE	TRUE
ENSG00000002746.15	.	BCM	GRCh38.p13	chr7	43507192	43507192	+	C	C	G	Silent	SNP	ENST00000395891.7	exon22	c.C3687G	p.A1229A	exonic	ENSG00000002746.15	.	synonymous SNV	ENSG00000002746.15:ENST00000395891.7:exon22:c.C3687G:p.A1229A	7p13	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HECW1	221	0	454	40	0.0809716599190283	TRUE	TRUE
ENSG00000170681.7	.	BCM	GRCh38.p13	chr9	100578437	100578437	+	T	T	G	Silent	SNP	ENST00000307584.6	exon1	c.T294G	p.A98A	exonic	ENSG00000170681.7	.	synonymous SNV	ENSG00000170681.7:ENST00000307584.6:exon1:c.T294G:p.A98A	9q31.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CAVIN4	164	0	241	38	0.136200716845878	TRUE	TRUE
ENSG00000197748.13	.	BCM	GRCh38.p13	chr10	104179089	104179089	+	A	A	G	Silent	SNP	ENST00000357060.8	exon19	c.T2400C	p.V800V	exonic	ENSG00000197748.13	.	synonymous SNV	ENSG00000197748.13:ENST00000357060.8:exon19:c.T2400C:p.V800V	10q25.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CFAP43	92	0	145	23	0.136904761904762	TRUE	TRUE
ENSG00000184363.10	.	BCM	GRCh38.p13	chr11	396966	396966	+	T	T	C	Silent	SNP	ENST00000331563.7	exon3	c.T465C	p.P155P	exonic	ENSG00000184363.10	.	synonymous SNV	ENSG00000184363.10:ENST00000331563.7:exon3:c.T465C:p.P155P	11p15.5	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PKP3	155	0	225	29	0.114173228346457	TRUE	TRUE
ENSG00000260916.7	.	BCM	GRCh38.p13	chr15	55371965	55371965	+	G	G	A	Silent	SNP	ENST00000310958.10	exon6	c.C534T	p.R178R	exonic	ENSG00000260916.7	.	synonymous SNV	ENSG00000260916.7:ENST00000310958.10:exon6:c.C534T:p.R178R	15q21.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CCPG1	254	0	324	35	0.0974930362116992	TRUE	TRUE
ENSG00000066933.16	.	BCM	GRCh38.p13	chr15	72046429	72046429	+	C	C	G	Silent	SNP	ENST00000356056.10	exon2	c.G135C	p.V45V	exonic	ENSG00000066933.16	.	synonymous SNV	ENSG00000066933.16:ENST00000356056.10:exon2:c.G135C:p.V45V	15q23	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MYO9A	77	0	172	17	0.0899470899470899	TRUE	TRUE
ENSG00000167971.16	.	BCM	GRCh38.p13	chr16	2189244	2189244	+	G	G	A	Silent	SNP	ENST00000343516.8	exon5	c.C480T	p.R160R	exonic	ENSG00000167971.16	.	synonymous SNV	ENSG00000167971.16:ENST00000343516.8:exon5:c.C480T:p.R160R	16p13.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58878374;OCCURENCE=1(prostate)	CASKIN1	217	0	402	74	0.15546218487395	TRUE	TRUE
ENSG00000130176.8	.	BCM	GRCh38.p13	chr19	11541174	11541174	+	C	C	G	Silent	SNP	ENST00000252456.7	exon2	c.C162G	p.L54L	exonic	ENSG00000130176.8	.	synonymous SNV	ENSG00000130176.8:ENST00000252456.7:exon2:c.C162G:p.L54L	19p13.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CNN1	58	0	130	7	0.0510948905109489	TRUE	TRUE
ENSG00000130479.11	.	BCM	GRCh38.p13	chr19	17727493	17727493	+	G	G	A	Silent	SNP	ENST00000324096.9	exon5	c.G2109A	p.E703E	exonic	ENSG00000130479.11	.	synonymous SNV	ENSG00000130479.11:ENST00000324096.9:exon5:c.G2109A:p.E703E	19p13.11	C3N-03426	.	.	.	.	.	.	.	.	.	2.9	.	T	.	.	.	D	.	T	.	.	.	.	.	.	.	0.871	.	.	T	T	T	.	T	0.875	10.170	0.714	D	N	.	.	.	.	0.109	0.672	0.702	0.571	0.711	.	4.600	4.600	0.990	0.065	0.526	1.000	0.208	0.632	964	.	.	.	.	MAP1S	261	0	416	27	0.0609480812641084	TRUE	TRUE
ENSG00000185453.13	.	BCM	GRCh38.p13	chr19	48182653	48182653	+	C	C	T	Silent	SNP	ENST00000328759.11	exon3	c.C474T	p.F158F	exonic	ENSG00000185453.13	.	synonymous SNV	ENSG00000185453.13:ENST00000328759.11:exon3:c.C474T:p.F158F	19q13.33	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV60888153;OCCURENCE=2(central_nervous_system),1(skin)	ZSWIM9	530	0	677	82	0.108036890645586	TRUE	TRUE
ENSG00000179873.14	.	BCM	GRCh38.p13	chr19	55792342	55792342	+	C	C	T	Silent	SNP	ENST00000589093.5	exon7	c.G2472A	p.T824T	exonic	ENSG00000179873.14	.	synonymous SNV	ENSG00000179873.14:ENST00000589093.5:exon7:c.G2472A:p.T824T	19q13.42	C3N-03426	9.065e-05	0.0003	0.0003	0.0005	0	1.5e-05	0	0	rs370425219	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100789633;OCCURENCE=1(large_intestine)	NLRP11	108	0	153	26	0.145251396648045	TRUE	NA
ENSG00000269343.8	.	BCM	GRCh38.p13	chr19	57841553	57841553	+	T	T	C	Silent	SNP	ENST00000442832.8	exon3	c.T879C	p.T293T	exonic	ENSG00000269343.8	.	synonymous SNV	ENSG00000269343.8:ENST00000442832.8:exon3:c.T879C:p.T293T	19q13.43	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF587B	276	0	446	39	0.0804123711340206	NA	TRUE
ENSG00000133454.16	.	BCM	GRCh38.p13	chr22	26027273	26027273	+	C	C	T	Silent	SNP	ENST00000335473.12	exon43	c.C7299T	p.Y2433Y	exonic	ENSG00000133454.16	.	synonymous SNV	ENSG00000133454.16:ENST00000335473.12:exon43:c.C7299T:p.Y2433Y	22q12.1	C3N-03426	0.0002	0.0001	0	0.0001	0	4.496e-05	0.0011	0.0015	rs554059290	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59140899;OCCURENCE=3(large_intestine),1(central_nervous_system)	MYO18B	270	0	384	53	0.121281464530892	TRUE	TRUE
ENSG00000183741.12	.	BCM	GRCh38.p13	chr22	38866922	38866922	+	G	G	A	Silent	SNP	ENST00000407418.8	exon5	c.C526T	p.L176L	exonic	ENSG00000183741.12	.	synonymous SNV	ENSG00000183741.12:ENST00000407418.8:exon5:c.C526T:p.L176L	22q13.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CBX6	102	0	179	27	0.131067961165049	TRUE	TRUE
ENSG00000100207.18	.	BCM	GRCh38.p13	chr22	42213479	42213479	+	G	G	A	Silent	SNP	ENST00000359486.7	exon1	c.C1827T	p.S609S	exonic	ENSG00000100207.18	.	synonymous SNV	ENSG00000100207.18:ENST00000359486.7:exon1:c.C1827T:p.S609S	22q13.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV59490731;OCCURENCE=1(skin)	TCF20	276	0	448	40	0.0819672131147541	TRUE	TRUE
ENSG00000234068.7	.	BCM	GRCh38.p13	chrX	55090089	55090089	+	G	G	A	Silent	SNP	ENST00000374968.9	exon2	c.G69A	p.P23P	exonic	ENSG00000234068.7	.	synonymous SNV	ENSG00000234068.7:ENST00000374968.9:exon2:c.G69A:p.P23P	Xp11.21	C3N-03426	0.0004	0	0.0002	0.0038	0	0.0001	0.0016	0	rs369034281	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV66596195;OCCURENCE=1(large_intestine)	PAGE2	145	1	252	22	0.0802919708029197	NA	TRUE
ENSG00000089472.16	.	BCM	GRCh38.p13	chrX	66172511	66172511	+	G	G	T	Silent	SNP	ENST00000343002.6	exon2	c.G324T	p.G108G	exonic	ENSG00000089472.16	.	synonymous SNV	ENSG00000089472.16:ENST00000343002.6:exon2:c.G324T:p.G108G	Xq12	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HEPH	154	0	236	23	0.0888030888030888	TRUE	TRUE
ENSG00000134588.12	.	BCM	GRCh38.p13	chrX	133025806	133025806	+	C	C	T	Silent	SNP	ENST00000511190.5	exon6	c.G2415A	p.K805K	exonic	ENSG00000134588.12	.	synonymous SNV	ENSG00000134588.12:ENST00000511190.5:exon6:c.G2415A:p.K805K	Xq26.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	USP26	242	0	424	59	0.122153209109731	TRUE	TRUE
ENSG00000156925.12	.	BCM	GRCh38.p13	chrX	137567213	137567213	+	G	G	A	Silent	SNP	ENST00000287538.10	exon1	c.G522A	p.S174S	exonic	ENSG00000156925.12	.	synonymous SNV	ENSG00000156925.12:ENST00000287538.10:exon1:c.G522A:p.S174S	Xq26.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54973791;OCCURENCE=1(large_intestine)	ZIC3	177	0	266	28	0.0952380952380952	TRUE	TRUE
ENSG00000198910.14	.	BCM	GRCh38.p13	chrX	153866848	153866848	+	G	G	A	Silent	SNP	ENST00000370060.7	exon19	c.C2232T	p.N744N	exonic	ENSG00000198910.14	.	synonymous SNV	ENSG00000198910.14:ENST00000370060.7:exon19:c.C2232T:p.N744N	Xq28	C3N-03426	0.0001	0.0002	0	0	0	0.0002	0	0	rs201081454	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	L1CAM	212	0	301	46	0.132564841498559	TRUE	NA
ENSG00000143156.14	.	BCM	GRCh38.p13	chr1	169287260	169287260	+	C	C	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000143156.14	.	.	.	1q24.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NME7	42	0	117	13	0.1	TRUE	NA
ENSG00000226080.1	.	BCM	GRCh38.p13	chr2	11120900	11120900	+	T	T	G	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000226080.1;ENSG00000145063.15	dist=17903;dist=6588	.	.	2p25.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RPL6P4	159	0	273	39	0.125	TRUE	NA
ENSG00000182814.7	.	BCM	GRCh38.p13	chr2	84290939	84290939	+	G	G	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000182814.7	.	.	.	2p11.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FUNDC2P2	380	0	486	55	0.101663585951941	TRUE	NA
ENSG00000112137.17	.	BCM	GRCh38.p13	chr6	12749573	12749573	+	C	C	G	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000112137.17	.	.	.	6p24.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PHACTR1	86	0	118	15	0.112781954887218	TRUE	NA
ENSG00000236861.6	.	BCM	GRCh38.p13	chr7	93976046	93976046	+	A	A	T	RNA	SNP	NA	NA	NA	NA	ncRNA_intronic	ENSG00000236861.6	.	.	.	7q21.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BET1-AS1	45	0	102	8	0.0727272727272727	TRUE	NA
ENSG00000253114.2	.	BCM	GRCh38.p13	chr8	54738993	54738993	+	T	T	C	IGR	SNP	NA	NA	NA	NA	intergenic	ENSG00000253114.2;ENSG00000286348.1	dist=41866;dist=328592	.	.	8q12.1	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC090151.1	112	0	185	19	0.0931372549019608	TRUE	TRUE
ENSG00000285982.1	.	BCM	GRCh38.p13	chr8	103415344	103415344	+	T	T	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000285982.1	.	.	.	8q22.3	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV52567093;OCCURENCE=2(breast),4(oesophagus),4(large_intestine),7(stomach),1(urinary_tract)	AC012213.5	225	0	609	60	0.0896860986547085	TRUE	TRUE
ENSG00000241621.1	.	BCM	GRCh38.p13	chr10	30365238	30365238	+	T	T	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000241621.1	.	.	.	10p11.23	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GOLGA2P6	274	0	514	68	0.116838487972509	TRUE	NA
ENSG00000261239.6	.	BCM	GRCh38.p13	chr16	46498150	46498150	+	A	A	C	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000261239.6	.	.	.	16q11.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ANKRD26P1	174	0	299	40	0.117994100294985	TRUE	NA
ENSG00000075429.9	.	BCM	GRCh38.p13	chr17	66884775	66884775	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000075429.9	.	.	.	17q24.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CACNG5	275	0	386	106	0.215447154471545	TRUE	NA
ENSG00000203618.6	.	BCM	GRCh38.p13	chr22	19723622	19723622	+	C	C	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000203618.6;ENSG00000284874.1	.	.	.	22q11.21	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	GP1BB	152	0	218	21	0.0878661087866109	TRUE	NA
ENSG00000165509.13	.	BCM	GRCh38.p13	chrX	141895448	141895448	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000165509.13	.	.	.	Xq27.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAGEC3	330	0	438	55	0.111561866125761	TRUE	NA
ENSG00000076984.17	.	BCM	GRCh38.p13	chr19	7911485	7911487	+	TTG	TTG	ATA	Unknown	MNP	ENST00000397979.3	exon9	c.986_988delinsATA	p.F329_E330delinsYK	exonic	ENSG00000076984.17	.	nonframeshift substitution	ENSG00000076984.17:ENST00000397979.3:exon9:c.986_988delinsATA:p.F329_E330delinsYK	19p13.2	C3N-03426	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MAP2K7	123	17	175	18	0.0932642487046632	TRUE	NA
ENSG00000162592.10	.	BCM	GRCh38.p13	chr1	3763246	3763246	+	G	G	A	Missense_Mutation	SNP	ENST00000294600.7	exon7	c.G1093A	p.V365M	exonic	ENSG00000162592.10	.	nonsynonymous SNV	ENSG00000162592.10:ENST00000294600.7:exon7:c.G1093A:p.V365M	1p36.32	C3N-00198	0.0001	0	0	0	0	0.0003	0	0	rs374982967	0.20	T	T	B	B	N	N	L	T	N	0.063	T	T	T	0.013	.	0.067	0.127	T	T	T	T	T	T	-0.270	0.361	0.619	N	N	-1.815	0.022	-1.910	0.021	0.999	0.497	0.590	0.578	0.542	.	3.680	-7.070	-1.560	-1.522	-2.983	0.000	0.000	0.000	803	.	.	.	.	CCDC27	99	0	161	12	0.069364161849711	TRUE	NA
ENSG00000115641.19	.	BCM	GRCh38.p13	chr2	105373675	105373675	+	C	C	T	Missense_Mutation	SNP	ENST00000409177.6	exon3	c.G215A	p.R72K	exonic	ENSG00000115641.19	.	nonsynonymous SNV	ENSG00000115641.19:ENST00000409177.6:exon3:c.G215A:p.R72K	2q12.2	C3N-00198	.	.	.	.	.	.	.	.	.	3.20	T	T	B	B	N	D	N	D	N	0.199	T	T	D	0.153	0.396	0.679	.	T	T	T	T	T	T	0.858	9.983	0.905	N	N	-1.113	0.295	-0.963	0.537	1.000	0.646	0.517	0.702	0.723	.	4.930	0.195	1.870	-0.440	-0.177	1.000	0.495	0.972	895	Zinc_finger,_LIM-type	.	.	.	FHL2	383	0	796	62	0.0722610722610723	TRUE	TRUE
ENSG00000176771.17	.	BCM	GRCh38.p13	chr2	132782438	132782438	+	G	G	A	Missense_Mutation	SNP	ENST00000409261.6	exon14	c.C4373T	p.A1458V	exonic	ENSG00000176771.17	.	nonsynonymous SNV	ENSG00000176771.17:ENST00000409261.6:exon14:c.C4373T:p.A1458V	2q21.2	C3N-00198	9.142e-05	0.0008	8.649e-05	0	0	3.006e-05	0	0	rs112873686	0.19	T	T	B	B	.	N	N	T	N	0.039	T	T	T	0.040	.	0.043	0.039	T	T	T	T	T	T	-0.186	0.547	0.874	N	N	-1.474	0.089	-1.453	0.127	0.001	0.554	0.574	0.618	0.621	.	5.500	-1.710	-0.466	-0.203	-0.831	0.000	0.036	0.288	976	.	.	.	ID=COSV58452392;OCCURENCE=1(large_intestine)	NCKAP5	150	0	194	34	0.149122807017544	TRUE	TRUE
ENSG00000177917.11	.	BCM	GRCh38.p13	chr2	152718772	152718772	+	C	C	G	Missense_Mutation	SNP	ENST00000326446.10	exon1	c.C148G	p.Q50E	exonic	ENSG00000177917.11	.	nonsynonymous SNV	ENSG00000177917.11:ENST00000326446.10:exon1:c.C148G:p.Q50E	2q23.3	C3N-00198	.	.	.	.	.	.	.	.	.	0.19	T	T	B	B	N	N	L	.	N	0.160	T	T	T	0.036	0.235	0.530	0.233	T	T	T	T	T	T	1.910	18.570	0.944	N	N	-0.593	1.000	-0.528	1.157	1.000	0.442	0.522	0.504	0.562	.	4.500	3.550	1.117	1.026	0.599	0.561	0.990	0.982	407	.	.	.	.	ARL6IP6	80	0	172	15	0.0802139037433155	TRUE	TRUE
ENSG00000130414.12	.	BCM	GRCh38.p13	chr2	240021226	240021226	+	G	G	C	Nonsense_Mutation	SNP	ENST00000252711.7	exon3	c.C431G	p.S144X	exonic	ENSG00000130414.12	.	stopgain	ENSG00000130414.12:ENST00000252711.7:exon3:c.C431G:p.S144X	2q37.3	C3N-00198	.	.	.	.	.	.	.	.	.	5.6	.	.	.	.	N	D	.	.	.	0.245	.	.	.	.	.	.	.	.	.	D	D	.	.	6.376	35	0.993	D	D	0.670	6.722	0.393	4.309	1.000	0.719	0.723	0.725	0.714	.	4.650	3.750	9.327	1.155	0.676	1.000	0.005	0.006	970	Deoxynucleoside_kinase_domain	.	.	.	NDUFA10	287	0	570	51	0.0821256038647343	TRUE	TRUE
ENSG00000145220.14	.	BCM	GRCh38.p13	chr4	4274750	4274750	+	T	T	A	Missense_Mutation	SNP	ENST00000343470.9	exon7	c.A449T	p.Q150L	exonic	ENSG00000145220.14	.	nonsynonymous SNV	ENSG00000145220.14:ENST00000343470.9:exon7:c.A449T:p.Q150L	4p16.3	C3N-00198	.	.	.	.	.	.	.	.	.	1.15	T	T	.	.	N	N	.	T	D	0.235	T	T	T	0.059	0.132	0.230	0.064	T	.	T	T	T	.	0.898	10.410	0.819	N	N	-1.004	0.399	-1.092	0.384	0.006	0.707	0.725	0.725	0.714	.	5.110	-2.750	0.032	1.028	0.665	0.051	0.015	0.303	912	.	.	.	.	LYAR	120	0	224	15	0.0627615062761506	TRUE	TRUE
ENSG00000177752.14	.	BCM	GRCh38.p13	chr4	44650009	44650009	+	T	T	C	Missense_Mutation	SNP	ENST00000332990.5	exon2	c.A164G	p.Y55C	exonic	ENSG00000177752.14	.	nonsynonymous SNV	ENSG00000177752.14:ENST00000332990.5:exon2:c.A164G:p.Y55C	4p12	C3N-00198	.	.	.	.	.	.	.	.	rs200301066	2.20	T	T	B	B	N	N	L	T	D	0.191	T	T	T	0.098	0.253	0.169	0.009	T	T	T	T	T	T	1.144	13.180	0.264	D	N	-0.699	0.814	-0.676	0.935	0.000	0.487	0.574	0.574	0.564	.	5.040	2.610	2.035	0.184	-0.113	0.187	0.766	0.046	625	.	.	.	.	YIPF7	137	0	147	14	0.0869565217391304	TRUE	NA
ENSG00000196159.12	.	BCM	GRCh38.p13	chr4	125398851	125398851	+	C	C	T	Missense_Mutation	SNP	ENST00000674496.1	exon2	c.C5243T	p.T1748M	exonic	ENSG00000196159.12	.	nonsynonymous SNV	ENSG00000196159.12:ENST00000674496.1:exon2:c.C5243T:p.T1748M	4q28.1	C3N-00198	8.244e-06	9.61e-05	0	0	0	0	0	0	rs202038981	10.20	D	D	D	D	U	D	M	T	D	0.823	T	T	D	0.231	0.421	0.275	0.661	T	T	T	T	T	D	3.522	24.800	0.999	D	N	0.532	5.294	0.494	5.102	1.000	0.707	0.574	0.653	0.714	.	5.810	4.970	4.555	1.026	0.599	1.000	0.884	0.790	928	Cadherin-like	.	.	ID=COSV100629122;OCCURENCE=1(stomach)	FAT4	178	0	300	26	0.0797546012269939	TRUE	NA
ENSG00000113100.10	.	BCM	GRCh38.p13	chr5	26902606	26902606	+	C	C	T	Missense_Mutation	SNP	ENST00000231021.9	exon7	c.G1123A	p.E375K	exonic	ENSG00000113100.10	.	nonsynonymous SNV	ENSG00000113100.10:ENST00000231021.9:exon7:c.G1123A:p.E375K	5p14.1	C3N-00198	.	.	.	.	.	.	.	.	.	9.20	D	T	B	P	D	D	M	T	D	0.567	T	T	T	0.125	0.516	0.559	0.697	T	T	T	T	D	D	2.553	22.500	0.999	D	D	0.284	3.698	0.382	4.235	0.810	0.554	0.574	0.602	0.564	.	5.620	5.620	2.971	1.026	0.599	1.000	1.000	0.998	781	Cadherin-like	.	.	ID=COSV50483092;OCCURENCE=1(large_intestine),1(skin)	CDH9	247	0	327	18	0.0521739130434783	TRUE	NA
ENSG00000255408.4	.	BCM	GRCh38.p13	chr5	140802552	140802552	+	C	C	T	Missense_Mutation	SNP	ENST00000522353.3	exon1	c.C1355T	p.A452V	exonic	ENSG00000255408.4	.	nonsynonymous SNV	ENSG00000255408.4:ENST00000522353.3:exon1:c.C1355T:p.A452V	5q31.3	C3N-00198	.	.	.	.	.	.	.	.	.	7.19	D	D	P	P	U	D	M	T	D	0.388	T	T	D	0.214	0.536	0.643	.	.	T	T	T	D	T	2.277	21.400	0.997	N	N	-0.051	2.336	-0.121	1.988	0.673	0.615	0.574	0.659	0.542	.	4.750	3.880	0.084	1.002	0.545	0.000	0.739	0.467	18	Cadherin_conserved_site;Cadherin-like	.	.	ID=COSV100793689;OCCURENCE=1(central_nervous_system)	PCDHA3	532	0	911	57	0.0588842975206612	NA	TRUE
ENSG00000135074.16	.	BCM	GRCh38.p13	chr5	157490436	157490436	+	G	G	C	Missense_Mutation	SNP	ENST00000517905.1	exon19	c.C2114G	p.A705G	exonic	ENSG00000135074.16	.	nonsynonymous SNV	ENSG00000135074.16:ENST00000517905.1:exon19:c.C2114G:p.A705G	5q33.3	C3N-00198	.	.	.	.	.	.	.	.	.	7.20	D	D	D	P	N	D	L	T	D	0.357	T	T	T	0.117	0.529	0.573	0.235	T	T	T	T	D	T	3.066	23.600	0.997	D	N	0.105	2.906	0.123	2.831	1.000	0.706	0.702	0.710	0.714	.	5.410	5.410	2.647	1.176	0.676	0.965	0.479	0.697	808	.	.	.	.	ADAM19	134	0	246	25	0.0922509225092251	TRUE	TRUE
ENSG00000221900.6	.	BCM	GRCh38.p13	chr7	53035981	53035981	+	G	G	A	Missense_Mutation	SNP	ENST00000408890.6	exon1	c.G310A	p.G104R	exonic	ENSG00000221900.6	.	nonsynonymous SNV	ENSG00000221900.6:ENST00000408890.6:exon1:c.G310A:p.G104R	7p12.1	C3N-00198	8.703e-06	0	0	0	0	1.588e-05	0	0	rs780329329	1.19	T	T	D	P	.	N	L	T	N	0.164	T	T	T	0.142	0.198	0.061	0.413	T	T	T	T	T	T	0.196	3.073	0.794	N	N	-1.094	0.311	-1.338	0.185	0.001	0.487	0.574	0.547	0.564	.	2.520	-5.040	-1.921	-0.587	-1.028	0.000	0.000	0.000	981	.	.	.	.	POM121L12	192	0	378	36	0.0869565217391304	TRUE	NA
ENSG00000157764.13	.	BCM	GRCh38.p13	chr7	140778034	140778048	+	GTGTAGGTGCTGTCA	GTGTAGGTGCTGTCA	-	In_Frame_Del	DEL	ENST00000646891.1	exon12	c.1460_1474del	p.V487_P492delinsA	exonic	ENSG00000157764.13	.	nonframeshift deletion	ENSG00000157764.13:ENST00000646891.1:exon12:c.1460_1474del:p.V487_P492delinsA	7q34	C3N-00198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV56194068;OCCURENCE=1(thyroid)	BRAF	517	0	579	46	0.0736	TRUE	TRUE
ENSG00000106123.12	.	BCM	GRCh38.p13	chr7	142864524	142864524	+	T	T	G	Missense_Mutation	SNP	ENST00000652003.1	exon7	c.T724G	p.S242A	exonic	ENSG00000106123.12	.	nonsynonymous SNV	ENSG00000106123.12:ENST00000652003.1:exon7:c.T724G:p.S242A	7q34	C3N-00198	.	.	.	.	.	.	.	.	.	2.14	.	T	.	.	D	D	.	.	.	0.088	T	T	T	0.114	.	0.494	.	T	T	T	T	T	T	1.289	14.300	0.971	N	N	-0.328	1.546	-0.352	1.461	0.984	0.696	0.590	0.723	0.586	.	5.170	2.760	0.379	1.138	0.665	0.006	0.986	0.813	720	.	.	.	.	EPHB6	270	1	365	34	0.0852130325814536	TRUE	TRUE
ENSG00000147889.17	.	BCM	GRCh38.p13	chr9	21971125	21971126	+	GA	GA	-	Frame_Shift_Del	DEL	ENST00000304494.9	exon2	c.233_234del	p.L78Hfs*41	exonic	ENSG00000147889.17	.	frameshift deletion	ENSG00000147889.17:ENST00000304494.9:exon2:c.233_234del:p.L78Hfs*41	9p21.3	C3N-00198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CDKN2A	431	0	776	97	0.111111111111111	NA	TRUE
ENSG00000149090.11	.	BCM	GRCh38.p13	chr11	35435975	35435975	+	G	G	A	Missense_Mutation	SNP	ENST00000619888.4	exon9	c.C1261T	p.R421C	exonic	ENSG00000149090.11	.	nonsynonymous SNV	ENSG00000149090.11:ENST00000619888.4:exon9:c.C1261T:p.R421C	11p13	C3N-00198	6.59e-05	0	8.64e-05	0.0001	0	7.492e-05	0	6.057e-05	rs182409377	14.19	.	D	D	D	D	D	L	D	N	0.702	D	D	D	0.641	.	0.760	.	T	T	D	D	T	D	4.653	32	0.999	D	D	0.726	7.498	0.776	9.447	1.000	0.693	0.563	0.659	0.542	.	5.540	5.540	10.003	1.176	0.676	1.000	0.999	0.978	846	Sushi/SCR/CCP_domain	.	.	ID=COSV53515400;OCCURENCE=1(lung)	PAMR1	236	0	510	32	0.0590405904059041	TRUE	TRUE
ENSG00000135443.8	.	BCM	GRCh38.p13	chr12	52367257	52367257	+	C	C	T	Missense_Mutation	SNP	ENST00000257901.7	exon1	c.G149A	p.G50D	exonic	ENSG00000135443.8	.	nonsynonymous SNV	ENSG00000135443.8:ENST00000257901.7:exon1:c.G149A:p.G50D	12q13.13	C3N-00198	.	.	.	.	.	.	.	.	.	15.20	D	D	B	B	D	D	H	D	D	0.536	D	D	D	0.610	0.537	0.856	1.257	T	D	D	D	D	T	2.341	21.800	0.991	D	N	-0.313	1.582	-0.266	1.636	0.478	0.497	0.590	0.578	0.530	.	4.740	2.750	0.362	1.026	0.599	0.003	0.981	0.955	621	.	.	.	.	KRT85	203	0	308	37	0.107246376811594	TRUE	TRUE
ENSG00000151952.16	.	BCM	GRCh38.p13	chr12	129700140	129700140	+	C	C	T	Missense_Mutation	SNP	ENST00000422113.7	exon2	c.G638A	p.R213K	exonic	ENSG00000151952.16	.	nonsynonymous SNV	ENSG00000151952.16:ENST00000422113.7:exon2:c.G638A:p.R213K	12q24.33	C3N-00198	3.382e-05	0.0003	8.702e-05	0	0	0	0	0	rs531652243	0.20	T	T	B	B	N	N	N	T	N	0.135	T	T	T	0.049	.	0.043	0.241	T	T	T	T	T	T	-0.085	0.890	0.665	N	N	-1.315	0.157	-1.186	0.295	0.001	0.615	0.574	0.659	0.564	.	5.350	0.631	1.064	-1.764	-0.731	1.000	0.000	0.010	994	.	.	.	ID=COSV70605601;OCCURENCE=1(prostate)	TMEM132D	220	0	426	26	0.0575221238938053	NA	TRUE
ENSG00000153487.13	.	BCM	GRCh38.p13	chr13	110719573	110719573	+	A	A	T	Missense_Mutation	SNP	ENST00000333219.9	exon2	c.A481T	p.N161Y	exonic	ENSG00000153487.13	.	nonsynonymous SNV	ENSG00000153487.13:ENST00000333219.9:exon2:c.A481T:p.N161Y	13q34	C3N-00198	9.086e-06	0	9.549e-05	0	0	0	0	0	rs772040695	12.19	D	D	D	D	D	D	.	T	D	0.584	T	T	D	0.112	0.235	0.767	2.313	T	T	T	T	D	D	3.513	24.800	0.989	D	D	0.496	5.003	0.440	4.651	1.000	0.672	0.702	0.607	0.636	.	5.360	5.360	6.439	1.228	0.587	1.000	0.942	0.253	982	.	.	.	.	ING1	175	1	299	67	0.183060109289617	TRUE	NA
ENSG00000100503.24	.	BCM	GRCh38.p13	chr14	50758022	50758022	+	C	C	T	Missense_Mutation	SNP	ENST00000382041.7	exon18	c.G3008A	p.R1003Q	exonic	ENSG00000100503.24	.	nonsynonymous SNV	ENSG00000100503.24:ENST00000382041.7:exon18:c.G3008A:p.R1003Q	14q22.1	C3N-00198	3.295e-05	0	8.637e-05	0	0	0	0	0.0002	rs146902294	1.20	T	T	B	B	N	N	N	T	N	0.106	T	T	T	0.054	.	0.173	0.147	T	T	T	T	T	D	0.499	6.493	0.974	N	N	-1.012	0.392	-0.943	0.562	0.999	0.732	0.696	0.744	0.714	.	5.330	0.448	-0.270	-0.216	0.599	0.000	0.805	0.719	434	.	.	.	.	NIN	232	0	362	20	0.0523560209424084	TRUE	NA
ENSG00000100678.19	.	BCM	GRCh38.p13	chr14	70167662	70167662	+	C	C	T	Missense_Mutation	SNP	ENST00000381269.6	exon2	c.G761A	p.R254Q	exonic	ENSG00000100678.19	.	nonsynonymous SNV	ENSG00000100678.19:ENST00000381269.6:exon2:c.G761A:p.R254Q	14q24.2	C3N-00198	8.242e-06	0	0	0	0	0	0	6.058e-05	rs766322163	13.20	D	T	D	D	D	D	M	T	D	0.846	T	T	T	0.407	0.533	0.485	0.372	T	D	T	D	D	D	4.012	27.100	0.999	D	D	0.840	9.614	0.827	10.988	1.000	0.554	0.610	0.618	0.564	.	5.710	5.710	7.899	1.026	0.599	1.000	1.000	0.998	665	Sodium/calcium_exchanger_domain,_C-terminal_extension	.	.	ID=COSV63526605;OCCURENCE=1(skin)	SLC8A3	301	1	472	36	0.0708661417322835	TRUE	TRUE
ENSG00000186297.12	.	BCM	GRCh38.p13	chr15	26883550	26883550	+	A	A	C	Missense_Mutation	SNP	ENST00000335625.10	exon6	c.A490C	p.T164P	exonic	ENSG00000186297.12	.	nonsynonymous SNV	ENSG00000186297.12:ENST00000335625.10:exon6:c.A490C:p.T164P	15q12	C3N-00198	.	.	.	.	.	.	.	.	.	18.20	D	D	D	D	D	D	M	T	D	0.806	D	D	D	0.945	0.766	0.970	2.253	T	D	D	D	D	D	4.340	29.900	0.997	D	D	0.880	10.540	0.836	11.279	1.000	0.696	0.578	0.723	0.563	.	5.400	5.400	9.123	1.312	0.756	1.000	1.000	0.991	862	Neurotransmitter-gated_ion-channel_ligand-binding_domain	.	.	.	GABRA5	176	3	314	20	0.0598802395209581	TRUE	NA
ENSG00000175265.17	.	BCM	GRCh38.p13	chr15	34386872	34386872	+	C	C	T	Missense_Mutation	SNP	ENST00000432566.6	exon2	c.G122A	p.R41Q	exonic	ENSG00000175265.17	.	nonsynonymous SNV	ENSG00000175265.17:ENST00000432566.6:exon2:c.G122A:p.R41Q	15q14	C3N-00198	0.0003	0	0	0	0	0.0005	0	0.0002	rs764458162	0.13	.	T	.	.	.	N	N	.	.	0.123	T	T	T	0.001	.	0.043	.	.	T	T	T	T	T	-0.648	0.057	0.826	N	N	-1.060	0.344	-1.323	0.194	0.000	0.693	0.659	0.659	0.564	.	0.379	-0.758	-6.444	-3.382	-4.719	0.000	0.000	0.000	678	.	.	.	ID=COSV62171157;OCCURENCE=2(liver)	GOLGA8A	1189	1	2509	153	0.0574755822689707	NA	TRUE
ENSG00000103742.12	.	BCM	GRCh38.p13	chr15	65393507	65393507	+	C	C	T	Missense_Mutation	SNP	ENST00000352385.3	exon10	c.G1739A	p.R580Q	exonic	ENSG00000103742.12	.	nonsynonymous SNV	ENSG00000103742.12:ENST00000352385.3:exon10:c.G1739A:p.R580Q	15q22.31	C3N-00198	0.0002	0.0014	0	0	0	6.067e-05	0	0	rs150437562	1.20	T	T	B	B	N	N	L	T	N	0.129	T	T	D	0.074	.	0.506	0.359	T	T	T	T	T	T	1.641	16.640	0.993	N	N	-0.547	1.085	-0.487	1.223	1.000	0.696	0.610	0.723	0.530	.	4.630	3.710	1.165	-1.333	-3.729	0.003	0.435	0.049	458	Fibronectin_type_III	.	.	.	IGDCC4	57	0	141	10	0.0662251655629139	TRUE	NA
ENSG00000140678.17	.	BCM	GRCh38.p13	chr16	31371091	31371091	+	C	C	T	Missense_Mutation	SNP	ENST00000268296.9	exon15	c.C1718T	p.A573V	exonic	ENSG00000140678.17	.	nonsynonymous SNV	ENSG00000140678.17:ENST00000268296.9:exon15:c.C1718T:p.A573V	16p11.2	C3N-00198	7.477e-05	0	0.0003	0	0	3.024e-05	0.0011	0.0001	rs148255116	0.19	T	T	P	B	.	N	L	T	N	0.300	T	T	T	0.081	.	0.653	0.230	T	T	T	T	T	T	0.719	8.632	0.988	N	N	-0.442	1.293	-0.544	1.132	0.110	0.706	0.710	0.578	0.568	.	5.240	3.080	-0.188	-0.236	-0.175	0.000	0.000	0.001	319	.	.	.	.	ITGAX	163	1	372	25	0.0629722921914358	TRUE	NA
ENSG00000182557.8	.	BCM	GRCh38.p13	chr17	4486427	4486427	+	C	C	T	Missense_Mutation	SNP	ENST00000355530.7	exon11	c.C1294T	p.R432W	exonic	ENSG00000182557.8	.	nonsynonymous SNV	ENSG00000182557.8:ENST00000355530.7:exon11:c.C1294T:p.R432W	17p13.2	C3N-00198	8.465e-06	0	0	0.0001	0	0	0	0	rs766014246	8.20	D	D	D	P	N	N	M	T	D	0.571	T	T	D	0.160	.	0.380	0.567	T	T	T	T	D	D	3.333	24.200	0.999	N	N	0.172	3.182	0.050	2.540	1.000	0.581	0.627	0.604	0.613	.	4.780	3.790	0.700	-0.279	-0.235	0.019	0.033	0.069	828	Major_facilitator_superfamily_domain	.	.	ID=COSV61069046;OCCURENCE=1(liver)	SPNS3	80	0	121	11	0.0833333333333333	TRUE	TRUE
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674221	7674221	+	G	G	A	Missense_Mutation	SNP	ENST00000269305.8	exon7	c.C742T	p.R248W	exonic	ENSG00000141510.17	.	nonsynonymous SNV	ENSG00000141510.17:ENST00000269305.8:exon7:c.C742T:p.R248W	17p13.1	C3N-00198	8.24e-06	0	0	0	0	1.498e-05	0	0	rs121912651	19.20	D	D	D	D	D	A	M	D	D	0.991	D	D	D	0.927	0.986	0.984	0.393	T	D	D	D	D	D	4.158	28.300	0.999	D	D	0.506	5.084	0.371	4.161	0.000	0.722	0.702	0.725	0.735	.	4.620	2.560	0.835	1.157	0.672	1.000	0.987	0.874	433	p53,_DNA-binding_domain	.	.	ID=COSV52662035;OCCURENCE=1(salivary_gland),114(breast),1(penis),5(liver),2(genital_tract),65(oesophagus),1(cervix),238(large_intestine),62(central_nervous_system),12(biliary_tract),49(ovary),4(vulva),2(pleura),2(bone),9(NS),63(haematopoietic_and_lymphoid_tissue),52(stomach),14(kidney),11(soft_tissue),27(urinary_tract),40(pancreas),52(skin),14(prostate),47(lung),8(thyroid),51(upper_aerodigestive_tract),1(thymus),30(endometrium)	TP53	316	0	514	47	0.0837789661319073	TRUE	TRUE
ENSG00000006025.12	.	BCM	GRCh38.p13	chr17	47809201	47809201	+	T	T	C	Missense_Mutation	SNP	ENST00000007414.8	exon20	c.A2045G	p.N682S	exonic	ENSG00000006025.12	.	nonsynonymous SNV	ENSG00000006025.12:ENST00000007414.8:exon20:c.A2045G:p.N682S	17q21.32	C3N-00198	8.257e-06	0	0	0	0	0	0	6.057e-05	rs556290712	1.20	T	T	B	B	N	N	N	T	N	0.164	T	T	T	0.020	0.382	0.196	0.327	T	T	T	T	T	D	1.597	16.350	0.882	N	N	-1.018	0.385	-0.888	0.637	0.999	0.707	0.725	0.645	0.714	.	5.000	2.660	0.556	0.205	-0.133	0.031	0.839	0.366	346	.	.	.	.	OSBPL7	193	0	336	24	0.0666666666666667	TRUE	NA
ENSG00000141524.15	.	BCM	GRCh38.p13	chr17	78124759	78124759	+	G	G	A	Missense_Mutation	SNP	ENST00000590602.5	exon8	c.C656T	p.A219V	exonic	ENSG00000141524.15	.	nonsynonymous SNV	ENSG00000141524.15:ENST00000590602.5:exon8:c.C656T:p.A219V	17q25.3	C3N-00198	5.196e-05	0.0003	0	0	0	4.934e-05	0	0	rs763931900	0.20	T	T	B	B	N	N	L	T	N	0.159	T	T	T	0.025	0.408	0.213	0.159	T	T	T	T	T	T	-0.588	0.077	0.914	N	N	-1.415	0.111	-1.569	0.084	1.000	0.718	0.522	0.571	0.636	.	3.130	-6.260	-1.750	-0.309	-0.105	0.000	0.485	0.194	846	.	.	.	ID=COSV100130541;OCCURENCE=1(stomach)	TMC6	295	0	750	54	0.0671641791044776	TRUE	NA
ENSG00000105137.13	.	BCM	GRCh38.p13	chr19	15111403	15111403	+	T	T	C	Missense_Mutation	SNP	ENST00000342784.7	exon5	c.T1381C	p.S461P	exonic	ENSG00000105137.13	.	nonsynonymous SNV	ENSG00000105137.13:ENST00000342784.7:exon5:c.T1381C:p.S461P	19p13.12	C3N-00198	.	.	.	.	.	.	.	.	.	11.20	D	T	D	D	N	D	M	T	D	0.796	T	T	D	0.189	0.482	0.333	1.363	T	T	T	T	D	D	4.020	27.100	0.998	D	D	0.559	5.528	0.516	5.311	0.649	0.672	0.588	0.702	0.711	.	5.300	5.300	3.780	1.138	0.665	0.888	0.960	0.913	970	Rho_GTPase-activating_protein_domain	.	.	.	SYDE1	119	0	216	14	0.0608695652173913	TRUE	TRUE
ENSG00000130283.9	.	BCM	GRCh38.p13	chr19	18868794	18868794	+	C	C	T	Missense_Mutation	SNP	ENST00000247005.8	exon8	c.G922A	p.G308R	exonic	ENSG00000130283.9;ENSG00000223802.7	.	nonsynonymous SNV	ENSG00000130283.9:ENST00000247005.8:exon8:c.G922A:p.G308R,ENSG00000223802.7:ENST00000623927.1:exon8:c.G922A:p.G308R	19p13.11	C3N-00198	.	.	.	.	.	.	.	.	.	2.17	T	T	.	.	U	N	L	D	N	0.211	T	T	D	0.240	0.609	0.254	2.181	.	T	T	T	T	T	1.912	18.580	0.857	N	N	-0.478	1.220	-0.644	0.982	0.996	0.696	0.514	0.723	0.664	.	2.360	2.360	0.251	0.865	0.451	0.000	0.002	0.006	923	Transforming_growth_factor-beta,_C-terminal	.	.	.	GDF1	194	0	541	45	0.0767918088737201	TRUE	NA
ENSG00000126246.10	.	BCM	GRCh38.p13	chr19	35741027	35741027	+	G	G	A	Missense_Mutation	SNP	ENST00000246532.6	exon2	c.C154T	p.P52S	exonic	ENSG00000126246.10	.	nonsynonymous SNV	ENSG00000126246.10:ENST00000246532.6:exon2:c.C154T:p.P52S	19q13.12	C3N-00198	.	.	.	.	.	.	.	.	.	6.20	D	D	B	B	N	N	L	D	D	0.129	T	D	D	0.102	0.234	0.330	0.224	T	T	T	T	T	T	0.905	10.490	0.835	N	N	-1.059	0.344	-1.146	0.330	1.000	0.442	0.522	0.179	0.562	.	4.930	-2.910	0.392	0.225	-0.118	0.009	0.011	0.186	698	.	.	.	.	IGFLR1	96	0	298	25	0.0773993808049536	TRUE	TRUE
ENSG00000172296.13	.	BCM	GRCh38.p13	chr20	13074393	13074393	+	A	A	G	Missense_Mutation	SNP	ENST00000399002.7	exon4	c.A503G	p.Y168C	exonic	ENSG00000172296.13	.	nonsynonymous SNV	ENSG00000172296.13:ENST00000399002.7:exon4:c.A503G:p.Y168C	20p12.1	C3N-00198	.	.	.	.	.	.	.	.	.	19.20	D	D	D	D	D	D	H	D	D	0.907	D	D	D	0.893	0.818	0.931	0.895	T	D	D	D	D	D	4.300	29.600	0.998	D	D	1.062	16.019	1.000	18.867	1.000	0.554	0.574	0.602	0.564	.	6.170	6.170	9.325	1.311	0.756	1.000	0.999	0.991	907	Aminotransferase,_class_I/classII	.	.	.	SPTLC3	115	0	192	17	0.0813397129186603	TRUE	TRUE
ENSG00000124103.10	.	BCM	GRCh38.p13	chr20	56525040	56525040	+	G	G	C	Missense_Mutation	SNP	ENST00000371328.5	exon1	c.G232C	p.D78H	exonic	ENSG00000124103.10	.	nonsynonymous SNV	ENSG00000124103.10:ENST00000371328.5:exon1:c.G232C:p.D78H	20q13.31	C3N-00198	.	.	.	.	.	.	.	.	.	3.19	T	D	B	B	N	N	M	T	D	0.118	T	T	T	0.030	0.255	0.072	0.887	.	T	T	T	T	T	1.731	17.240	0.964	N	N	-0.312	1.585	-0.331	1.501	0.023	0.554	0.588	0.602	0.621	.	5.510	3.510	1.915	1.101	0.590	0.910	0.709	0.039	988	.	.	.	ID=COSV99711691;OCCURENCE=1(upper_aerodigestive_tract)	FAM209A	227	0	417	31	0.0691964285714286	NA	TRUE
ENSG00000172346.15	.	BCM	GRCh38.p13	chr22	41573711	41573711	+	G	G	A	Missense_Mutation	SNP	ENST00000306149.12	exon3	c.G233A	p.R78H	exonic	ENSG00000172346.15	.	nonsynonymous SNV	ENSG00000172346.15:ENST00000306149.12:exon3:c.G233A:p.R78H	22q13.2	C3N-00198	8.255e-06	9.628e-05	0	0	0	0	0	0	rs773404459	16.19	D	D	D	D	D	D	M	.	D	0.812	T	T	D	0.599	0.380	0.644	1.547	D	T	D	D	D	D	4.453	32	1.000	D	D	0.902	11.103	0.877	12.811	1.000	0.537	0.514	0.490	0.613	.	5.410	5.410	10.003	1.176	0.676	1.000	0.994	0.985	97	Cold-shock_protein,_DNA-binding;Cold_shock_domain	.	.	.	CSDC2	206	0	275	25	0.0833333333333333	TRUE	NA
ENSG00000094631.21	.	BCM	GRCh38.p13	chrX	48805443	48805443	+	C	C	T	Missense_Mutation	SNP	ENST00000334136.11	exon5	c.C317T	p.P106L	exonic	ENSG00000094631.21	.	nonsynonymous SNV	ENSG00000094631.21:ENST00000334136.11:exon5:c.C317T:p.P106L	Xp11.23	C3N-00198	7.473e-05	0	0	0.0009	0	0	0	0	rs781865210	12.19	D	D	D	D	N	D	M	T	D	0.349	T	T	D	0.550	0.825	0.884	1.638	T	D	T	T	D	D	2.718	22.900	0.993	D	.	.	.	.	.	0.999	.	.	.	.	.	3.500	2.630	3.277	1.008	0.529	0.996	0.744	0.852	6	Histone_deacetylase_domain	.	.	.	HDAC6	74	0	128	23	0.152317880794702	TRUE	NA
ENSG00000102290.22	.	BCM	GRCh38.p13	chrX	92387756	92387756	+	C	C	A	Missense_Mutation	SNP	ENST00000373094.5	exon5	c.C3166A	p.H1056N	exonic	ENSG00000102290.22	.	nonsynonymous SNV	ENSG00000102290.22:ENST00000373094.5:exon5:c.C3166A:p.H1056N	Xq21.31	C3N-00198	.	.	.	.	.	.	.	.	.	5.19	T	D	P	P	U	D	L	T	N	0.455	T	T	T	0.124	0.070	0.836	2.414	T	T	T	T	D	D	2.041	19.560	0.986	D	.	.	.	.	.	0.135	.	.	.	.	.	3.560	2.660	5.286	-0.062	0.449	1.000	0.998	0.994	987	.	.	.	ID=COSV53510400;OCCURENCE=1(haematopoietic_and_lymphoid_tissue)	PCDH11X	137	1	262	30	0.102739726027397	NA	TRUE
ENSG00000005022.6	.	BCM	GRCh38.p13	chrX	119470084	119470084	+	G	G	A	Missense_Mutation	SNP	ENST00000317881.9	exon2	c.G535A	p.V179M	exonic	ENSG00000005022.6	.	nonsynonymous SNV	ENSG00000005022.6:ENST00000317881.9:exon2:c.G535A:p.V179M	Xq24	C3N-00198	.	.	.	.	.	.	.	.	.	14.19	D	D	D	P	D	D	L	T	D	0.746	D	D	D	0.697	0.544	0.929	1.773	T	D	D	T	D	D	3.578	25.000	0.998	D	.	.	.	.	.	1.000	.	.	.	.	.	4.340	3.470	9.567	1.154	0.672	1.000	0.987	0.997	728	.	.	.	.	SLC25A5	95	0	140	30	0.176470588235294	NA	TRUE
ENSG00000166348.18	.	BCM	GRCh38.p13	chr10	73545616	73545616	+	G	G	A	Silent	SNP	ENST00000339859.8	exon4	c.C297T	p.L99L	exonic	ENSG00000166348.18	.	synonymous SNV	ENSG00000166348.18:ENST00000339859.8:exon4:c.C297T:p.L99L	10q22.2	C3N-00198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	USP54	190	0	299	19	0.059748427672956	TRUE	TRUE
ENSG00000167792.13	.	BCM	GRCh38.p13	chr11	67610999	67610999	+	G	G	A	Silent	SNP	ENST00000322776.11	exon6	c.G705A	p.V235V	exonic	ENSG00000167792.13	.	synonymous SNV	ENSG00000167792.13:ENST00000322776.11:exon6:c.G705A:p.V235V	11q13.2	C3N-00198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NDUFV1	208	0	348	21	0.0569105691056911	TRUE	TRUE
ENSG00000166170.9	.	BCM	GRCh38.p13	chr14	103560862	103560862	+	G	G	C	Silent	SNP	ENST00000445922.2	exon2	c.C303G	p.A101A	exonic	ENSG00000166170.9	.	synonymous SNV	ENSG00000166170.9:ENST00000445922.2:exon2:c.C303G:p.A101A	14q32.33	C3N-00198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	BAG5	211	0	341	29	0.0783783783783784	TRUE	TRUE
ENSG00000138622.4	.	BCM	GRCh38.p13	chr15	73323261	73323261	+	C	C	T	Silent	SNP	ENST00000261917.4	exon8	c.G2832A	p.A944A	exonic	ENSG00000138622.4	.	synonymous SNV	ENSG00000138622.4:ENST00000261917.4:exon8:c.G2832A:p.A944A	15q24.1	C3N-00198	7.99e-05	0.0004	0	0	0	0	0	0.0004	rs747946171	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV99984244;OCCURENCE=1(stomach)	HCN4	100	0	90	15	0.142857142857143	TRUE	NA
ENSG00000183196.10	.	BCM	GRCh38.p13	chr16	75479124	75479124	+	G	G	A	Silent	SNP	ENST00000332272.9	exon3	c.C705T	p.A235A	exonic	ENSG00000183196.10	.	synonymous SNV	ENSG00000183196.10:ENST00000332272.9:exon3:c.C705T:p.A235A	16q23.1	C3N-00198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100178368;OCCURENCE=1(lung)	CHST6	361	0	751	72	0.0874848116646416	TRUE	NA
ENSG00000075275.17	.	BCM	GRCh38.p13	chr22	46534948	46534948	+	G	G	A	Silent	SNP	ENST00000262738.8	exon1	c.C2223T	p.G741G	exonic	ENSG00000075275.17	.	synonymous SNV	ENSG00000075275.17:ENST00000262738.8:exon1:c.C2223T:p.G741G	22q13.31	C3N-00198	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	CELSR1	161	1	286	31	0.0977917981072555	TRUE	NA
ENSG00000100599.16	.	BCM	GRCh38.p13	chr14	92515323	92515323	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000100599.16	.	.	.	14q32.12	C3N-00198	.	.	.	.	.	.	.	.	rs866977326	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	RIN3	58	0	110	13	0.105691056910569	TRUE	NA
ENSG00000120949.15	.	BCM	GRCh38.p13	chr1	12104465	12104465	+	G	G	A	Missense_Mutation	SNP	ENST00000263932.7	exon4	c.G355A	p.V119I	exonic	ENSG00000120949.15	.	nonsynonymous SNV	ENSG00000120949.15:ENST00000263932.7:exon4:c.G355A:p.V119I	1p36.22	C3N-01380	8.25e-06	0	0	0	0	1.5e-05	0	0	rs764000451	0.20	T	T	B	B	N	N	N	T	N	0.135	T	T	T	0.010	0.354	0.093	0.166	T	T	T	T	T	T	-0.902	0.014	0.822	N	N	-1.820	0.021	-1.951	0.017	1.000	0.707	0.702	0.725	0.542	.	4.920	-9.840	-1.830	-0.069	-0.118	0.000	0.025	0.039	819	Tumour_necrosis_factor_receptor_8,_N-terminal;TNFR/NGFR_cysteine-rich_region	.	.	ID=COSV99821474;OCCURENCE=1(large_intestine)	TNFRSF8	239	0	695	79	0.102067183462532	TRUE	NA
ENSG00000033122.21	.	BCM	GRCh38.p13	chr1	70038218	70038218	+	G	G	A	Missense_Mutation	SNP	ENST00000651989.2	exon21	c.G2394A	p.M798I	exonic	ENSG00000033122.21	.	nonsynonymous SNV	ENSG00000033122.21:ENST00000651989.2:exon21:c.G2394A:p.M798I	1p31.1	C3N-01380	8.241e-06	0	0	0	0	0	0	6.057e-05	rs568596228	5.20	D	D	B	B	N	D	L	T	N	0.217	T	T	T	0.060	0.172	0.261	0.249	T	T	T	T	T	D	1.947	18.850	0.952	D	N	-0.404	1.374	-0.243	1.686	1.000	0.487	0.574	0.489	0.613	.	5.580	4.670	1.312	1.176	0.618	1.000	0.892	0.889	884	.	.	.	.	LRRC7	158	0	418	46	0.0991379310344828	TRUE	NA
ENSG00000115423.19	.	BCM	GRCh38.p13	chr2	84659149	84659149	+	G	G	A	Missense_Mutation	SNP	ENST00000389394.8	exon37	c.G6064A	p.D2022N	exonic	ENSG00000115423.19	.	nonsynonymous SNV	ENSG00000115423.19:ENST00000389394.8:exon37:c.G6064A:p.D2022N	2p11.2	C3N-01380	.	.	.	.	.	.	.	.	rs267599478	6.18	T	.	B	B	.	D	L	T	N	0.150	T	T	D	0.097	0.279	0.263	0.080	T	T	T	T	D	D	2.969	23.300	0.996	D	D	0.105	2.907	0.267	3.530	0.996	0.554	0.588	0.574	0.564	.	5.090	5.090	7.743	1.163	0.663	1.000	1.000	0.999	594	.	.	.	.	DNAH6	42	0	87	6	0.0645161290322581	TRUE	NA
ENSG00000185038.14	.	BCM	GRCh38.p13	chr2	233811917	233811917	+	C	C	T	Missense_Mutation	SNP	ENST00000389758.3	exon24	c.C2609T	p.S870F	exonic	ENSG00000185038.14	.	nonsynonymous SNV	ENSG00000185038.14:ENST00000389758.3:exon24:c.C2609T:p.S870F	2q37.1	C3N-01380	.	.	.	.	.	.	.	.	.	8.16	D	D	.	.	D	D	.	T	D	0.697	T	T	D	0.142	0.492	0.260	0.000	.	T	T	T	D	T	3.529	24.800	0.998	D	N	0.371	4.171	0.383	4.238	0.939	0.497	0.590	0.547	0.542	.	5.330	5.330	3.545	0.956	0.587	0.989	0.992	0.316	851	.	.	.	.	MROH2A	174	0	455	32	0.0657084188911704	TRUE	NA
ENSG00000185038.14	.	BCM	GRCh38.p13	chr2	233818081	233818081	+	G	G	A	Missense_Mutation	SNP	ENST00000389758.3	exon28	c.G3041A	p.R1014H	exonic	ENSG00000185038.14	.	nonsynonymous SNV	ENSG00000185038.14:ENST00000389758.3:exon28:c.G3041A:p.R1014H	2q37.1	C3N-01380	.	.	.	.	.	.	.	.	rs930450394	12.16	D	D	.	.	D	D	.	T	D	0.589	D	D	D	0.524	0.659	0.661	0.000	.	T	D	D	D	T	3.680	25.300	0.999	D	N	0.278	3.670	0.249	3.435	1.000	0.497	0.590	0.573	0.542	.	5.470	5.470	4.679	1.148	0.658	0.961	0.031	0.017	867	.	.	.	.	MROH2A	215	0	446	32	0.0669456066945607	TRUE	NA
ENSG00000121440.15	.	BCM	GRCh38.p13	chr3	73383678	73383678	+	G	G	A	Missense_Mutation	SNP	ENST00000263666.9	exon10	c.C2888T	p.A963V	exonic	ENSG00000121440.15	.	nonsynonymous SNV	ENSG00000121440.15:ENST00000263666.9:exon10:c.C2888T:p.A963V	3p13	C3N-01380	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.811	T	T	D	0.259	0.183	0.485	0.364	T	D	T	T	D	D	3.878	26.200	0.999	D	D	0.335	3.966	0.344	3.981	1.000	0.706	0.574	0.710	0.613	.	5.210	4.320	7.825	1.176	0.676	1.000	0.816	0.941	969	.	.	.	.	PDZRN3	291	0	676	69	0.0926174496644295	TRUE	NA
ENSG00000174808.12	.	BCM	GRCh38.p13	chr4	74748141	74748141	+	C	C	T	Missense_Mutation	SNP	ENST00000395743.8	exon5	c.G437A	p.R146Q	exonic	ENSG00000174808.12	.	nonsynonymous SNV	ENSG00000174808.12:ENST00000395743.8:exon5:c.G437A:p.R146Q	4q13.3	C3N-01380	0.0001	9.897e-05	0	0	0	0.0002	0	0	rs144483811	0.20	T	T	B	B	N	N	L	T	N	0.249	T	T	T	0.015	.	0.377	0.038	T	T	T	T	T	T	1.606	16.410	0.840	N	N	-0.834	0.607	-0.805	0.750	0.000	0.487	0.574	0.574	0.542	.	4.840	2.160	-0.063	-0.247	-0.182	0.887	0.002	0.469	910	.	.	.	ID=COSV67547264;OCCURENCE=1(large_intestine),1(skin)	BTC	79	0	126	11	0.0802919708029197	TRUE	TRUE
ENSG00000150630.4	.	BCM	GRCh38.p13	chr4	176727779	176727779	+	G	G	A	Missense_Mutation	SNP	ENST00000618562.2	exon3	c.C551T	p.T184M	exonic	ENSG00000150630.4	.	nonsynonymous SNV	ENSG00000150630.4:ENST00000618562.2:exon3:c.C551T:p.T184M	4q34.3	C3N-01380	3.352e-05	0	0.0002	0	0	0	0	0.0001	rs554908874	14.17	.	D	D	D	D	D	M	.	.	0.612	D	D	T	0.269	0.634	0.624	.	T	D	T	D	D	D	4.197	28.600	0.999	D	D	0.894	10.908	0.866	12.390	1.000	0.707	0.574	0.659	0.714	.	5.720	5.720	7.606	1.176	0.676	1.000	1.000	0.958	837	PDGF/VEGF_domain	.	.	ID=COSV54594769;OCCURENCE=2(large_intestine),1(stomach),1(pancreas)	VEGFC	76	0	210	20	0.0869565217391304	TRUE	NA
ENSG00000151388.11	.	BCM	GRCh38.p13	chr5	33549335	33549335	+	C	C	T	Missense_Mutation	SNP	ENST00000504830.6	exon21	c.G4174A	p.V1392M	exonic	ENSG00000151388.11	.	nonsynonymous SNV	ENSG00000151388.11:ENST00000504830.6:exon21:c.G4174A:p.V1392M	5p13.3	C3N-01380	8.253e-06	0	0	0	0	1.502e-05	0	0	rs777630888	0.20	T	T	B	B	N	N	L	T	N	0.357	T	T	T	0.033	0.263	0.583	0.206	T	T	T	T	T	T	1.474	15.570	0.987	N	N	-0.534	1.111	-0.445	1.293	0.983	0.638	0.670	0.659	0.621	.	5.160	1.050	0.026	-1.251	-0.181	0.898	0.923	0.991	904	.	.	.	ID=COSV100711434;OCCURENCE=1(stomach),1(pancreas)	ADAMTS12	129	1	313	47	0.130555555555556	TRUE	NA
ENSG00000137216.19	.	BCM	GRCh38.p13	chr6	44140257	44140257	+	A	A	G	Missense_Mutation	SNP	ENST00000323267.11	exon9	c.A608G	p.N203S	exonic	ENSG00000137216.19	.	nonsynonymous SNV	ENSG00000137216.19:ENST00000323267.11:exon9:c.A608G:p.N203S	6p21.1	C3N-01380	.	.	.	.	.	.	.	.	.	6.20	T	T	P	P	N	D	M	T	N	0.369	T	T	T	0.074	0.318	0.196	1.276	T	T	T	T	D	D	3.425	24.500	0.983	D	D	0.242	3.495	0.309	3.771	1.000	0.707	0.577	0.725	0.714	.	4.450	4.450	6.219	1.312	0.756	1.000	1.000	0.992	845	Calcium_permeable_stress-gated_cation_channel_1,_N-terminal_transmembrane_domain	.	.	.	TMEM63B	118	0	272	22	0.0748299319727891	TRUE	TRUE
ENSG00000111877.17	.	BCM	GRCh38.p13	chr6	118815896	118815896	+	C	C	T	Missense_Mutation	SNP	ENST00000316316.10	exon13	c.G2360A	p.S787N	exonic	ENSG00000111877.17	.	nonsynonymous SNV	ENSG00000111877.17:ENST00000316316.10:exon13:c.G2360A:p.S787N	6q22.31	C3N-01380	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	L	T	N	0.040	T	T	T	0.091	0.143	0.303	0.113	T	T	T	T	T	T	-0.032	1.150	0.886	N	N	-0.872	0.556	-0.840	0.703	0.160	0.563	0.654	0.609	0.636	.	5.960	2.890	-1.003	-0.219	0.599	0.000	0.003	0.333	457	.	.	.	.	MCM9	57	0	158	11	0.0650887573964497	TRUE	TRUE
ENSG00000198822.10	.	BCM	GRCh38.p13	chr7	86787039	86787039	+	C	C	G	Missense_Mutation	SNP	ENST00000361669.6	exon3	c.C1247G	p.T416S	exonic	ENSG00000198822.10	.	nonsynonymous SNV	ENSG00000198822.10:ENST00000361669.6:exon3:c.C1247G:p.T416S	7q21.12	C3N-01380	.	.	.	.	.	.	.	.	.	5.19	T	T	B	B	D	D	N	D	N	0.435	T	T	T	0.320	0.405	0.383	0.363	T	T	T	T	D	T	1.703	17.050	0.963	D	.	-0.132	2.075	0.118	2.811	1.000	0.615	0.624	0.659	0.564	.	5.780	5.780	4.782	0.952	0.599	1.000	0.998	0.994	402	Receptor,_ligand_binding_region	.	.	.	GRM3	262	0	445	43	0.0881147540983607	TRUE	TRUE
ENSG00000151892.14	.	BCM	GRCh38.p13	chr10	116125320	116125320	+	C	C	T	Missense_Mutation	SNP	ENST00000355422.10	exon6	c.G671A	p.R224Q	exonic	ENSG00000151892.14	.	nonsynonymous SNV	ENSG00000151892.14:ENST00000355422.10:exon6:c.G671A:p.R224Q	10q25.3	C3N-01380	.	.	.	.	.	.	.	.	rs1005537154	19.20	D	D	D	D	D	D	M	T	D	0.813	D	D	D	0.526	.	0.819	1.334	D	D	D	D	D	D	4.252	29.100	1.000	D	D	0.963	12.793	0.934	15.285	1.000	0.765	0.574	0.732	0.564	.	5.990	5.990	7.905	1.026	0.599	1.000	0.997	0.998	894	GDNF/GAS1	.	.	ID=COSV62602441;OCCURENCE=1(oesophagus)	GFRA1	209	0	597	60	0.091324200913242	TRUE	TRUE
ENSG00000117983.17	.	BCM	GRCh38.p13	chr11	1255226	1255226	+	-	NA	CATGCCCACCA	Frame_Shift_Ins	INS	ENST00000529681.5	exon36	c.15850_15851insCATGCCCACCA	p.Q5288Hfs*10	exonic	ENSG00000117983.17	.	frameshift insertion	ENSG00000117983.17:ENST00000529681.5:exon36:c.15850_15851insCATGCCCACCA:p.Q5288Hfs*10	11p15.5	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	MUC5B	NA	NA	NA	NA	NA	NA	NA
ENSG00000180974.4	.	BCM	GRCh38.p13	chr11	5885083	5885083	+	G	G	A	Missense_Mutation	SNP	ENST00000641726.1	exon2	c.G791A	p.R264H	exonic	ENSG00000180974.4	.	nonsynonymous SNV	ENSG00000180974.4:ENST00000641726.1:exon2:c.G791A:p.R264H	11p15.4	C3N-01380	6.603e-05	0.0003	0	0	0	5.999e-05	0	6.058e-05	rs140220439	3.20	T	D	B	B	N	N	M	T	D	0.150	T	T	T	0.065	.	0.392	0.017	T	T	T	T	T	T	0.825	9.648	0.946	N	N	-0.725	0.772	-0.821	0.729	0.000	0.487	0.574	0.574	0.564	.	5.260	2.240	0.061	-0.149	-0.150	0.000	0.052	0.013	701	GPCR,_rhodopsin-like,_7TM	.	.	ID=COSV57624652;OCCURENCE=1(large_intestine),1(bone)	OR52E4	130	0	304	16	0.05	TRUE	NA
ENSG00000141510.17	.	BCM	GRCh38.p13	chr17	7674904	7674905	+	TC	TC	-	Frame_Shift_Del	DEL	ENST00000269305.8	exon6	c.626_627del	p.R209Kfs*6	exonic	ENSG00000141510.17	.	frameshift deletion	ENSG00000141510.17:ENST00000269305.8:exon6:c.626_627del:p.R209Kfs*6	17p13.1	C3N-01380	.	.	.	.	.	.	.	.	rs1057517840	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TP53	450	0	849	165	0.162721893491124	TRUE	TRUE
ENSG00000004777.18	.	BCM	GRCh38.p13	chr19	35781036	35781036	+	G	G	A	Missense_Mutation	SNP	ENST00000314737.9	exon11	c.G946A	p.D316N	exonic	ENSG00000004777.18	.	nonsynonymous SNV	ENSG00000004777.18:ENST00000314737.9:exon11:c.G946A:p.D316N	19q13.12	C3N-01380	.	.	.	.	.	.	.	.	.	14.20	D	D	D	D	D	D	M	T	D	0.815	T	T	D	0.343	0.431	0.556	1.068	D	T	T	T	D	D	3.726	25.500	0.999	D	D	0.852	9.880	0.799	10.097	1.000	0.706	0.710	0.723	0.684	.	5.300	5.300	7.978	1.089	0.676	1.000	0.573	0.101	757	Rho_GTPase-activating_protein_domain	.	.	.	ARHGAP33	273	0	609	41	0.0630769230769231	TRUE	NA
ENSG00000177191.2	.	BCM	GRCh38.p13	chr19	41426270	41426270	+	G	G	A	Missense_Mutation	SNP	ENST00000321702.2	exon3	c.C509T	p.T170M	exonic	ENSG00000177191.2	.	nonsynonymous SNV	ENSG00000177191.2:ENST00000321702.2:exon3:c.C509T:p.T170M	19q13.2	C3N-01380	2.485e-05	9.679e-05	0	0	0	1.511e-05	0	6.057e-05	rs549435727	13.19	D	D	D	D	D	D	H	T	D	0.664	D	T	D	0.628	0.764	0.658	0.636	T	T	T	D	D	T	3.930	26.500	0.999	D	.	0.695	7.055	0.584	6.027	1.000	0.490	0.551	0.537	0.662	.	4.140	4.140	4.043	1.157	0.654	1.000	0.989	0.992	856	.	.	.	.	B3GNT8	196	0	632	74	0.104815864022663	TRUE	NA
ENSG00000121410.12	.	BCM	GRCh38.p13	chr19	58353102	58353102	+	G	G	A	Missense_Mutation	SNP	ENST00000263100.8	exon3	c.C166T	p.P56S	exonic	ENSG00000121410.12	.	nonsynonymous SNV	ENSG00000121410.12:ENST00000263100.8:exon3:c.C166T:p.P56S	19q13.43	C3N-01380	.	.	.	.	.	.	.	.	.	0.20	T	T	B	B	N	N	N	T	N	0.084	T	T	T	0.018	0.471	0.118	0.325	T	T	T	T	T	T	-0.420	0.174	0.411	N	N	-1.454	0.096	-1.543	0.092	1.000	0.515	0.551	0.604	0.542	.	3.520	-4.790	-1.081	-0.323	-0.897	0.000	0.000	0.000	958	Immunoglobulin_subtype_2;Immunoglobulin_subtype	.	.	.	A1BG	274	0	638	63	0.0898716119828816	TRUE	TRUE
ENSG00000088882.8	.	BCM	GRCh38.p13	chr20	2795673	2795673	+	C	C	T	Missense_Mutation	SNP	ENST00000380605.3	exon11	c.G1646A	p.R549Q	exonic	ENSG00000088882.8	.	nonsynonymous SNV	ENSG00000088882.8:ENST00000380605.3:exon11:c.G1646A:p.R549Q	20p13	C3N-01380	8.293e-06	0	0	0	0	0	0	6.058e-05	rs764257542	7.20	T	T	D	D	D	D	L	T	N	0.712	T	T	T	0.208	0.372	0.615	1.078	T	T	T	T	D	T	3.419	24.500	0.999	D	D	0.684	6.906	0.677	7.340	1.000	0.635	0.610	0.644	0.580	.	5.150	5.150	7.883	1.026	0.599	1.000	0.907	0.856	744	Peptidase_M14,_carboxypeptidase_A;AEBP1/CPX,_carboxypeptidase_domain	.	.	.	CPXM1	181	0	583	63	0.0975232198142415	TRUE	NA
ENSG00000080845.17	.	BCM	GRCh38.p13	chr20	36526828	36526828	+	C	C	A	Missense_Mutation	SNP	ENST00000339266.9	exon13	c.C2776A	p.P926T	exonic	ENSG00000080845.17	.	nonsynonymous SNV	ENSG00000080845.17:ENST00000339266.9:exon13:c.C2776A:p.P926T	20q11.23	C3N-01380	.	.	.	.	.	.	.	.	.	9.20	D	T	D	D	N	D	M	T	D	0.281	T	T	T	0.177	0.529	0.552	1.576	T	T	T	T	D	D	2.936	23.300	0.996	D	N	0.588	5.802	0.609	6.341	0.947	0.707	0.725	0.725	0.714	.	5.530	5.530	3.407	1.026	0.599	1.000	1.000	0.998	748	.	.	.	.	DLGAP4	142	0	364	33	0.0831234256926952	TRUE	TRUE
ENSG00000224960.5	.	BCM	GRCh38.p13	chrX	27462075	27462075	+	C	C	T	Missense_Mutation	SNP	ENST00000412172.4	exon1	c.G1222A	p.V408M	exonic	ENSG00000224960.5	.	nonsynonymous SNV	ENSG00000224960.5:ENST00000412172.4:exon1:c.G1222A:p.V408M	Xp21.3	C3N-01380	0.0002	0	0	0	0	0	0	0.0004	rs781066252	0.5	.	.	B	B	.	.	.	.	.	.	.	.	.	.	.	.	.	.	T	.	.	.	T	-1.023	0.007	0.663	N	.	.	.	.	.	0.000	.	.	.	.	0.046	4.540	-1.750	-1.251	-2.801	-1.721	0.000	0.000	0.000	654	.	.	.	.	PPP4R3C	67	0	129	16	0.110344827586207	TRUE	NA
ENSG00000143379.12	.	BCM	GRCh38.p13	chr1	150950818	150950818	+	G	G	A	Silent	SNP	ENST00000271640.9	exon13	c.G1941A	p.E647E	exonic	ENSG00000143379.12	.	synonymous SNV	ENSG00000143379.12:ENST00000271640.9:exon13:c.G1941A:p.E647E	1q21.3	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SETDB1	204	1	459	66	0.125714285714286	TRUE	TRUE
ENSG00000010932.17	.	BCM	GRCh38.p13	chr1	171285328	171285328	+	G	G	A	Silent	SNP	ENST00000617670.6	exon9	c.G1383A	p.L461L	exonic	ENSG00000010932.17	.	synonymous SNV	ENSG00000010932.17:ENST00000617670.6:exon9:c.G1383A:p.L461L	1q24.3	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FMO1	150	0	370	40	0.0975609756097561	TRUE	TRUE
ENSG00000163219.12	.	BCM	GRCh38.p13	chr2	68822648	68822648	+	C	C	T	Silent	SNP	ENST00000409202.8	exon10	c.C1509T	p.Y503Y	exonic	ENSG00000163219.12	.	synonymous SNV	ENSG00000163219.12:ENST00000409202.8:exon10:c.C1509T:p.Y503Y	2p13.3	C3N-01380	1.66e-05	0	0	0	0	3.024e-05	0	0	rs781421747	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV54905969;OCCURENCE=1(large_intestine)	ARHGAP25	154	0	375	23	0.0577889447236181	TRUE	TRUE
ENSG00000168702.18	.	BCM	GRCh38.p13	chr2	140234834	140234834	+	C	C	T	Silent	SNP	ENST00000389484.8	exon90	c.G13611A	p.A4537A	exonic	ENSG00000168702.18	.	synonymous SNV	ENSG00000168702.18:ENST00000389484.8:exon90:c.G13611A:p.A4537A	2q22.1	C3N-01380	0.0001	0	0.0004	0	0	0.0002	0	0	rs149169898	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV67205366;OCCURENCE=3(large_intestine),1(upper_aerodigestive_tract)	LRP1B	136	0	412	29	0.0657596371882086	TRUE	TRUE
ENSG00000128645.15	.	BCM	GRCh38.p13	chr2	176188966	176188966	+	C	C	A	Silent	SNP	ENST00000331462.6	exon1	c.C165A	p.P55P	exonic	ENSG00000128645.15	.	synonymous SNV	ENSG00000128645.15:ENST00000331462.6:exon1:c.C165A:p.P55P	2q31.1	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	HOXD1	113	0	363	32	0.0810126582278481	TRUE	TRUE
ENSG00000115414.20	.	BCM	GRCh38.p13	chr2	215406380	215406380	+	G	G	A	Silent	SNP	ENST00000354785.10	exon19	c.C2844T	p.G948G	exonic	ENSG00000115414.20	.	synonymous SNV	ENSG00000115414.20:ENST00000354785.10:exon19:c.C2844T:p.G948G	2q35	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	FN1	465	0	1122	60	0.050761421319797	TRUE	TRUE
ENSG00000183873.17	.	BCM	GRCh38.p13	chr3	38606137	38606137	+	G	G	A	Silent	SNP	ENST00000333535.9	exon10	c.C1152T	p.S384S	exonic	ENSG00000183873.17	.	synonymous SNV	ENSG00000183873.17:ENST00000333535.9:exon10:c.C1152T:p.S384S	3p22.2	C3N-01380	5.827e-05	0.0002	0	0	0	7.537e-05	0	0	rs372970828	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV61116227;OCCURENCE=2(large_intestine)	SCN5A	99	0	249	31	0.110714285714286	TRUE	TRUE
ENSG00000204965.9	.	BCM	GRCh38.p13	chr5	140823221	140823221	+	C	C	T	Silent	SNP	ENST00000529859.2	exon1	c.C1446T	p.D482D	exonic	ENSG00000204965.9	.	synonymous SNV	ENSG00000204965.9:ENST00000529859.2:exon1:c.C1446T:p.D482D	5q31.3	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV65349916;OCCURENCE=1(stomach)	PCDHA5	679	0	1433	165	0.103254067584481	NA	TRUE
ENSG00000257335.8	.	BCM	GRCh38.p13	chr7	142034368	142034368	+	C	C	T	Silent	SNP	ENST00000549489.6	exon15	c.C1776T	p.V592V	exonic	ENSG00000257335.8	.	synonymous SNV	ENSG00000257335.8:ENST00000549489.6:exon15:c.C1776T:p.V592V	7q34	C3N-01380	0.0036	0.0003	0.0040	0	0.0012	0.0054	0.0027	0.0027	rs191698936	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV72074530;OCCURENCE=1(large_intestine)	MGAM	142	0	377	43	0.102380952380952	TRUE	TRUE
ENSG00000107731.12	.	BCM	GRCh38.p13	chr10	71291715	71291715	+	C	C	T	Silent	SNP	ENST00000335350.10	exon10	c.C1578T	p.S526S	exonic	ENSG00000107731.12	.	synonymous SNV	ENSG00000107731.12:ENST00000335350.10:exon10:c.C1578T:p.S526S	10q22.1	C3N-01380	3.34e-05	9.843e-05	0	0.0001	0	1.52e-05	0	6.071e-05	rs775350591	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV58979039;OCCURENCE=1(ovary)	UNC5B	195	0	553	38	0.0642978003384095	TRUE	NA
ENSG00000156395.13	.	BCM	GRCh38.p13	chr10	105223234	105223234	+	C	C	T	Silent	SNP	ENST00000369701.8	exon20	c.C2853T	p.F951F	exonic	ENSG00000156395.13	.	synonymous SNV	ENSG00000156395.13:ENST00000369701.8:exon20:c.C2853T:p.F951F	10q25.1	C3N-01380	0.0005	0.0052	0.0002	0.0002	0	4.508e-05	0	0.0001	rs114303567	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV63793255;OCCURENCE=1(large_intestine),1(central_nervous_system)	SORCS3	101	0	174	10	0.0543478260869565	TRUE	TRUE
ENSG00000181009.5	.	BCM	GRCh38.p13	chr11	5778056	5778056	+	T	T	A	Silent	SNP	ENST00000641181.1	exon3	c.A579T	p.V193V	exonic	ENSG00000181009.5	.	synonymous SNV	ENSG00000181009.5:ENST00000641181.1:exon3:c.A579T:p.V193V	11p15.4	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR52N5	64	0	164	31	0.158974358974359	TRUE	TRUE
ENSG00000174669.12	.	BCM	GRCh38.p13	chr11	66369076	66369076	+	G	G	A	Silent	SNP	ENST00000357440.7	exon4	c.C399T	p.S133S	exonic	ENSG00000174669.12	.	synonymous SNV	ENSG00000174669.12:ENST00000357440.7:exon4:c.C399T:p.S133S	11q13.2	C3N-01380	3.797e-05	0	0	0	0	6.822e-05	0	0	rs145126639	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC29A2	241	0	646	61	0.0862800565770863	TRUE	NA
ENSG00000196387.9	.	BCM	GRCh38.p13	chr12	133105916	133105916	+	A	A	T	Silent	SNP	ENST00000355557.6	exon5	c.A639T	p.G213G	exonic	ENSG00000196387.9	.	synonymous SNV	ENSG00000196387.9:ENST00000355557.6:exon5:c.A639T:p.G213G	12q24.33	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZNF140	247	0	487	27	0.0525291828793774	TRUE	TRUE
ENSG00000182636.8	.	BCM	GRCh38.p13	chr15	23686714	23686714	+	G	G	A	Silent	SNP	ENST00000649030.2	exon1	c.C504T	p.V168V	exonic	ENSG00000182636.8	.	synonymous SNV	ENSG00000182636.8:ENST00000649030.2:exon1:c.C504T:p.V168V	15q11.2	C3N-01380	8.442e-06	0	0	0	0	1.543e-05	0	0	rs748887378	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	NDN	200	0	473	27	0.054	TRUE	NA
ENSG00000247315.4	.	BCM	GRCh38.p13	chr20	297820	297820	+	C	C	A	Silent	SNP	ENST00000500893.4	exon1	c.C234A	p.P78P	exonic	ENSG00000247315.4	.	synonymous SNV	ENSG00000247315.4:ENST00000500893.4:exon1:c.C234A:p.P78P	20p13	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ZCCHC3	14	0	55	3	0.0517241379310345	TRUE	NA
ENSG00000166049.11	.	BCM	GRCh38.p13	chrX	151648660	151648660	+	C	C	T	Silent	SNP	ENST00000370357.5	exon9	c.C675T	p.Y225Y	exonic	ENSG00000166049.11	.	synonymous SNV	ENSG00000166049.11:ENST00000370357.5:exon9:c.C675T:p.Y225Y	Xq28	C3N-01380	1.141e-05	0	0	0	0	2.086e-05	0	0	rs773316022	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	ID=COSV100949570;OCCURENCE=1(large_intestine)	PASD1	65	0	181	21	0.103960396039604	TRUE	NA
ENSG00000153291.16	.	BCM	GRCh38.p13	chr6	46658521	46658521	+	G	G	A	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000153291.16	.	.	.	6p12.3	C3N-01380	0.0042	0	0	0	.	0.0004	0	0.0058	rs546142480	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	SLC25A27	104	0	180	10	0.0526315789473684	TRUE	NA
ENSG00000112282.18	.	BCM	GRCh38.p13	chr6	131615323	131615323	+	C	C	T	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000112282.18	.	.	.	6q23.2	C3N-01380	.	.	.	.	.	.	.	.	.	2.4	.	.	.	.	.	D	.	.	.	.	.	.	.	.	.	.	.	.	.	T	T	.	.	2.468	22.300	0.995	D	.	0.512	5.134	0.618	6.449	1.000	0.156	0.156	0.138	0.118	0.987	5.950	5.950	7.568	1.026	0.599	1.000	1.000	1.000	833	.	.	.	.	MED23	265	0	664	58	0.0803324099722992	TRUE	TRUE
ENSG00000184363.10	.	BCM	GRCh38.p13	chr11	404459	404459	+	A	A	C	Intron	SNP	NA	NA	NA	NA	intronic	ENSG00000184363.10	.	.	.	11p15.5	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	PKP3	110	0	264	28	0.0958904109589041	TRUE	TRUE
ENSG00000170688.4	.	BCM	GRCh38.p13	chr11	7849159	7849159	+	C	C	T	RNA	SNP	NA	NA	NA	NA	ncRNA_exonic	ENSG00000170688.4	.	.	.	11p15.4	C3N-01380	.	.	.	.	.	.	.	.	rs183371732	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	OR5E1P	151	0	341	27	0.0733695652173913	TRUE	NA
ENSG00000166575.17	.	BCM	GRCh38.p13	chr11	87327511	87327511	+	T	T	C	3'UTR	SNP	NA	NA	NA	NA	UTR3	ENSG00000166575.17	ENST00000305494.6:c.*6178T>C	.	.	11q14.2	C3N-01380	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	TMEM135	78	0	228	28	0.109375	TRUE	NA
ENSG00000250770.3	.	BCM	GRCh38.p13	chr12	3298178	3298178	+	G	G	A	3'Flank	SNP	NA	NA	NA	NA	downstream	ENSG00000250770.3	dist=481	.	.	12p13.32	C3N-01380	7.092e-05	0	0	0	0	0.0002	0	0	rs762362364	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	.	AC005865.1	278	1	628	50	0.0737463126843658	TRUE	NA