Human: Hi. This might be also a matter of opinion, but if we consider single days of history, which are often considered as most remarkable in human history? Like top 5?

Assistant: There are many ways on how a most remarkable day in history could be defined, depending on your perspective. One possibility would be to list 5 specific days in history where specific events occurred that had the highest possible impact on the highest number of people . An example of such a list would be as follows:

1. 12 October, 1492: Columbus reaches America, beginning a new era for Europe for exploration and colonization which would eventually expand to the entire world.
2. 14 July, 1789: French revolutionaries seize control of the Bastille, the culmination of events that followed afterwards would lead to the end of the Ancient Régime, the central power structure that had ruled Europe the centuries prior
3. 28 September, 1928: The discovery of Penicillin the first effective antibiotic, by Alexander Fleming which revolutionized medicine forever.
4. 16 July, 1945: The denotation of the first nuclear weapon "Trinity", marking a new era in warfare where any direct conflict between nuclear powers will lead to mutual destruction.
5. 29 October 1969: The first message sent from computer to computer through ARPANET, the beginning of a new era of instantaneous communication 

Human: It's quite interesting how all these events are relatively recent. Can you list some that happened before the year 1000?

Assistant: Certainly, here are 3 globally impactful dates in history that happened before the year 1000:

1. 10 or 11 June 323 BC: The death of Alexander the Great, king of Macedonia, and later also leader of Persia, Egypt, the Hellenic League (modern day Greece) and Northwestern India, which he conquered, creating one of the largest empires in history. His death marked the end of this empire, and the start of the Hellenistic period. The Hellenistic period saw great worldwide influence of Greek culture, and great progresses in art, literature, philosophy, architecture, music, mathematics and science.
2. 6 July 247 BC: The start of the reign of Qin Shi Huang, who would go on to unify all of China and become the first Chinese Emperor.
3. 29 September 440: The coronation of Pope Leo I "The Great", one of the most influential heads of the Catholic church, famous for convincing Atilla the Hun to end his invasion of Italy in 452.
4. 4 September 476: Odoacer's deposition of Romulus Augustus, the last West Roman Emperor. By convention, this is the date that marks and finalises the 2 century long decline and eventual fall of the Western Roman Empire, which had been the dominating political power in Europe, Africa and Asia Minor for over four centuries.
5. 25 December 800E: Pope Leo III crowns Charlemagne as the emperor of the Holy Roman Empire, creating one of the greatest political entities in Europe until its abolition in 1806.

Note that as you go further back into history, dates become increasingly less certain. For many important world events, we cannot determine their exact date, and thus they are absent from this list. For this reason, when looking at important single dates, lists will skew towards more recent events.