Vanquish44/Healthcare_NLP huggingface dataset:
Question: What causes Tetralogy of Fallot ?
Answer: Doctors often don't know what causes tetralogy of Fallot and other congenital heart defects.
                
Some conditions or factors that occur during pregnancy may raise your risk of having a child who has tetralogy of Fallot. These conditions and factors include:
                
German measles (rubella) and some other viral illnesses
                
Poor nutrition
                
Alcohol use
                
Age (being older than 40)
                
Diabetes
                
Heredity may play a role in causing tetralogy of Fallot. An adult who has tetralogy of Fallot may be more likely than other people to have a baby with the condition.
                
Children who have certain genetic disorders, such as Down syndrome and DiGeorge syndrome, often have congenital heart defects, including tetralogy of Fallot.
                
Researchers continue to search for the causes of tetralogy of Fallot and other congenital heart defects.

Topic: Tetralogy of Fallot
Source: NHLBI
Question: What are the symptoms of Tetralogy of Fallot ?
Answer: Cyanosis is an important sign of tetralogy of Fallot. Cyanosis is a bluish tint to the skin, lips, and fingernails. Low oxygen levels in the blood cause cyanosis.
                
Babies who have unrepaired tetralogy of Fallot sometimes have "tet spells." These spells happen in response to an activity like crying or having a bowel movement.
                
A tet spell occurs when the oxygen level in the blood suddenly drops. This causes the baby to become very blue. The baby also may:
                
Have a hard time breathing
                
Become very tired and limp
                
Not respond to a parent's voice or touch
                
Become very fussy
                
Pass out
                
In years past, when tetralogy of Fallot wasn't treated in infancy, children would get very tired during exercise and could faint. Now, doctors repair tetralogy of Fallot in infancy to prevent these symptoms.
                
Another common sign of tetralogy of Fallot is a heart murmur. A heart murmur is an extra or unusual sound that doctors might hear while listening to the heart.
                
The sound occurs because the heart defect causes abnormal blood flow through the heart. However, not all heart murmurs are signs of congenital heart defects. Many healthy children have heart murmurs.
                
Babies who have tetralogy of Fallot may tire easily while feeding. Thus, they may not gain weight or grow as quickly as children who have healthy hearts. Also, normal growth depends on a normal workload for the heart and normal flow of oxygen-rich blood to all parts of the body.
                
Children who have tetralogy of Fallot also may have clubbing. Clubbing is the widening or rounding of the skin or bone around the tips of the fingers.

Topic: Tetralogy of Fallot
Source: NHLBI
Question: What is (are) Heart Murmur ?
Answer: A heart murmur is an extra or unusual sound heard during a heartbeat. Murmurs range from very faint to very loud. Sometimes they sound like a whooshing or swishing noise.
                
Normal heartbeats make a "lub-DUPP" or "lub-DUB" sound. This is the sound of the heart valves closing as blood moves through the heart. Doctors can hear these sounds and heart murmurs using a stethoscope.
                
Overview
                
The two types of heart murmurs are innocent (harmless) and abnormal.
                
Innocent heart murmurs aren't caused by heart problems. These murmurs are common in healthy children. Many children will have heart murmurs heard by their doctors at some point in their lives.
                
People who have abnormal heart murmurs may have signs or symptoms of heart problems. Most abnormal murmurs in children are caused by congenital (kon-JEN-ih-tal) heart defects. These defects are problems with the heart's structure that are present at birth.
                
In adults, abnormal heart murmurs most often are caused by acquired heart valve disease. This is heart valve disease that develops as the result of another condition. Infections, diseases, and aging can cause heart valve disease.
                
Outlook
                
A heart murmur isn't a disease, and most murmurs are harmless. Innocent murmurs don't cause symptoms. Having one doesn't require you to limit your physical activity or do anything else special. Although you may have an innocent murmur throughout your life, you won't need treatment for it.
                
The outlook and treatment for abnormal heart murmurs depend on the type and severity of the heart problem causing them.

Topic: Heart Murmur
Source: NHLBI
Question: What are the symptoms of Heart Murmur ?
Answer: People who have innocent (harmless) heart murmurs don't have any signs or symptoms other than the murmur itself. This is because innocent heart murmurs aren't caused by heart problems.
                
People who have abnormal heart murmurs may have signs or symptoms of the heart problems causing the murmurs. These signs and symptoms may include:
                
Poor eating and failure to grow normally (in infants)
                
Shortness of breath, which may occur only with physical exertion
                
Excessive sweating with minimal or no exertion
                
Chest pain
                
Dizziness or fainting
                
A bluish color on the skin, especially on the fingertips and lips
                
Chronic cough
                
Swelling or sudden weight gain
                
Enlarged liver
                
Enlarged neck veins
                
Signs and symptoms depend on the problem causing the heart murmur and its severity.

Topic: Heart Murmur
Source: NHLBI
Question: What are the treatments for Heart Murmur ?
Answer: A heart murmur isn't a disease. It's an extra or unusual sound heard during the heartbeat. Thus, murmurs themselves don't require treatment. However, if an underlying condition is causing a heart murmur, your doctor may recommend treatment for that condition.
                
Innocent (Harmless) Heart Murmurs
                
Healthy children who have innocent (harmless) heart murmurs don't need treatment. Their heart murmurs aren't caused by heart problems or other conditions.
                
Pregnant women who have innocent heart murmurs due to extra blood volume also don't need treatment. Their heart murmurs should go away after pregnancy.
                
Abnormal Heart Murmurs
                
If you or your child has an abnormal heart murmur, your doctor will recommend treatment for the disease or condition causing the murmur.
                
Some medical conditions, such as anemia or hyperthyroidism, can cause heart murmurs that aren't related to heart disease. Treating these conditions should make the heart murmur go away.
                
If a congenital heart defect is causing a heart murmur, treatment will depend on the type and severity of the defect. Treatment may include medicines or surgery. For more information about treatments for congenital heart defects, go to the Health Topics Congenital Heart Defects article.
                
If acquired heart valve disease is causing a heart murmur, treatment usually will depend on the type, amount, and severity of the disease.
                
Currently, no medicines can cure heart valve disease. However, lifestyle changes and medicines can treat symptoms and help delay complications. Eventually, though, you may need surgery to repair or replace a faulty heart valve.
                
For more information about treatments for heart valve disease, go to the Health Topics Heart Valve Disease article.

Topic: Heart Murmur
Source: NHLBI
Question: What causes Marfan Syndrome ?
Answer: Marfan syndrome is a genetic disorder. A mutation, or change, in the gene that controls how the body makes fibrillin causes Marfan syndrome. Fibrillin is a protein that plays a major role in your body's connective tissue.
                
Most people who have Marfan syndrome inherit it from their parents. If you have the condition, you have a 50 percent chance of passing the altered gene to each of your children.
                
Sometimes Marfan syndrome isn't inherited. The mutation in the fibrillin gene occurs in the egg or sperm cells. If a child is conceived, the altered gene may be passed on to the child. The risk of that child's brothers or sisters having Marfan syndrome is low.

Topic: Marfan Syndrome
Source: NHLBI
Question: Who is at risk for Marfan Syndrome? ?
Answer: People at highest risk for Marfan syndrome are those who have a family history of the condition. If you have Marfan syndrome, you have a 50 percent chance of passing the altered gene to each of your children.
                
Marfan syndrome affects about 1 out of every 5,000 people in the United States. Men, women, and children, and people of all races, can have the condition.

Topic: Marfan Syndrome
Source: NHLBI
Question: What is (are) Heart Palpitations ?
Answer: Palpitations (pal-pi-TA-shuns) are feelings that your heart is skipping a beat, fluttering, or beating too hard or too fast. You may have these feelings in your chest, throat, or neck. They can occur during activity or even when you're sitting still or lying down.
                
Overview
                
Many things can trigger palpitations, including:
                
Strong emotions
                
Vigorous physical activity
                
Medicines such as diet pills and decongestants
                
Caffeine, alcohol, nicotine, and illegal drugs
                
Certain medical conditions, such as thyroid disease or anemia (uh-NEE-me-uh)
                
These factors can make the heart beat faster or stronger than usual, or they can cause premature (extra) heartbeats. In these situations, the heart is still working normally. Thus, these palpitations usually are harmless.
                
Some palpitations are symptoms of arrhythmias (ah-RITH-me-ahs). Arrhythmias are problems with the rate or rhythm of the heartbeat.
                
Some arrhythmias are signs of heart conditions, such as heart attack, heart failure, heart valve disease, or heart muscle disease. However, less than half of the people who have palpitations have arrhythmias.
                
You can take steps to reduce or prevent palpitations. Try to avoid things that trigger them (such as stress and stimulants) and treat related medical conditions.
                
Outlook
                
Palpitations are very common. They usually aren't serious or harmful, but they can be bothersome. If you have them, your doctor can decide whether you need treatment or ongoing care.

Topic: Heart Palpitations
Source: NHLBI
Question: Who is at risk for Heart Palpitations? ?
Answer: Some people may be more likely than others to have palpitations. People at increased risk include those who:
                
Have anxiety or panic attacks, or people who are highly stressed
                
Take certain medicines or stimulants
                
Have certain medical conditions that aren't related to heart problems, such as an overactive thyroid
                
Have certain heart problems, such as arrhythmias (irregular heartbeats), a previous heart attack, heart failure, heart valve disease, or heart muscle disease
                
Women who are pregnant, menstruating, or perimenopausal also may be at higher risk for palpitations because of hormonal changes. Some palpitations that occur during pregnancy may be due to anemia.
                
For more information about these risk factors, go to "What Causes Palpitations?"

Topic: Heart Palpitations
Source: NHLBI
Question: What are the symptoms of Heart Palpitations ?
Answer: Symptoms of palpitations include feelings that your heart is:
                
Skipping a beat
                
Fluttering
                
Beating too hard or too fast
                
You may have these feelings in your chest, throat, or neck. They can occur during activity or even when you're sitting still or lying down.
                
Palpitations often are harmless, and your heart is working normally. However, these feelings can be a sign of a more serious problem if you also:
                
Feel dizzy or confused
                
Are light-headed, think you may faint, or do faint
                
Have trouble breathing
                
Have pain, pressure, or tightness in your chest, jaw, or arms
                
Feel short of breath
                
Have unusual sweating
                
Your doctor may have already told you that your palpitations are harmless. Even so, see your doctor again if your palpitations:
                
Start to occur more often or are more noticeable or bothersome
                
Occur with other symptoms, such as those listed above
                
Your doctor will want to check whether your palpitations are the symptom of a heart problem, such as an arrhythmia (irregular heartbeat).

Topic: Heart Palpitations
Source: NHLBI
Question: What are the treatments for Heart Palpitations ?
Answer: Treatment for palpitations depends on their cause. Most palpitations are harmless and often go away on their own. In these cases, no treatment is needed.
                
Avoiding Triggers
                
Your palpitations may be harmless but bothersome. If so, your doctor may suggest avoiding things that trigger them. For examples, your doctor may advise you to:
                
Reduce anxiety and stress. Anxiety and stress (including panic attacks) are a common cause of harmless palpitations. Relaxation exercises, yoga or tai chi, biofeedback or guided imagery, or aromatherapy may help you relax.
                
Avoid or limit stimulants, such as caffeine, nicotine, or alcohol.
                
Avoid illegal drugs, such as cocaine and amphetamines.
                
Avoid medicines that act as stimulants, such as cough and cold medicines and some herbal and nutritional supplements.
                
Treating Medical Conditions That May Cause Palpitations
                
Work with your doctor to control medical conditions that can cause palpitations, such as an overactive thyroid. If you're taking medicine that's causing palpitations, your doctor will try to find a different medicine for you.
                
If your palpitations are caused by an arrhythmia (irregular heartbeat), your doctor may recommend medicines or procedures to treat the problem. For more information, go to the Health Topics Arrhythmia article.

Topic: Heart Palpitations
Source: NHLBI
Question: How to prevent Heart Palpitations ?
Answer: You can take steps to prevent palpitations. Try to avoid things that trigger them. For example:
                
Reduce anxiety and stress. Anxiety and stress (including panic attacks) are a common cause of harmless palpitations. Relaxation exercises, yoga or tai chi, biofeedback or guided imagery, or aromatherapy may help you relax.
                
Avoid or limit stimulants, such as caffeine, nicotine, or alcohol.
                
Avoid illegal drugs, such as cocaine and amphetamines.
                
Avoid medicines that act as stimulants, such as cough and cold medicines and some herbal and nutritional supplements.
                
Also, work with your doctor to treat medical conditions that can cause palpitations.

Topic: Heart Palpitations
Source: NHLBI
Question: What is (are) Thalassemias ?
Answer: Thalassemias (thal-a-SE-me-ahs) are inherited blood disorders. "Inherited" means that the disorder is passed from parents to children through genes.
                
Thalassemias cause the body to make fewer healthy red blood cells and less hemoglobin (HEE-muh-glow-bin) than normal. Hemoglobin is an iron-rich protein in red blood cells. It carries oxygen to all parts of the body. Hemoglobin also carries carbon dioxide (a waste gas) from the body to the lungs, where it's exhaled.
                
People who have thalassemias can have mild or severe anemia (uh-NEE-me-uh). Anemia is caused by a lower than normal number of red blood cells or not enough hemoglobin in the red blood cells.
                
Overview
                
Normal hemoglobin, also called hemoglobin A, has four protein chainstwo alpha globin and two beta globin. The two major types of thalassemia, alpha and beta, are named after defects in these protein chains.
                
Four genes (two from each parent) are needed to make enough alpha globin protein chains. Alpha thalassemia trait occurs if one or two of the four genes are missing. If more than two genes are missing, moderate to severe anemia occurs.
                
The most severe form of alpha thalassemia is called alpha thalassemia major or hydrops fetalis. Babies who have this disorder usually die before or shortly after birth.
                
Two genes (one from each parent) are needed to make enough beta globin protein chains. Beta thalassemia occurs if one or both genes are altered.
                
The severity of beta thalassemia depends on how much one or both genes are affected. If both genes are affected, the result is moderate to severe anemia. The severe form of beta thalassemia is known as thalassemia major or Cooley's anemia.
                
Thalassemias affect males and females. The disorders occur most often among people of Italian, Greek, Middle Eastern, Southern Asian, and African descent. Severe forms usually are diagnosed in early childhood and are lifelong conditions.
                
Doctors diagnose thalassemias using blood tests. The disorders are treated with blood transfusions, medicines, and other procedures.
                
Outlook
                
Treatments for thalassemias have improved over the years. People who have moderate or severe thalassemias are now living longer and have better quality of life.
                
However, complications from thalassemias and their treatments are frequent. People who have moderate or severe thalassemias must closely follow their treatment plans. They need to take care of themselves to remain as healthy as possible.

Topic: Thalassemias
Source: NHLBI
Question: What causes Thalassemias ?
Answer: Your body makes three types of blood cells: red blood cells, white blood cells, and platelets (PLATE-lets). Red blood cells contain hemoglobin, an iron-rich protein that carries oxygen from your lungs to all parts of your body. Hemoglobin also carries carbon dioxide (a waste gas) from your body to your lungs, where it's exhaled.
                
Hemoglobin has two kinds of protein chains: alpha globin and beta globin. If your body doesn't make enough of these protein chains or they're abnormal, red blood cells won't form correctly or carry enough oxygen. Your body won't work well if your red blood cells don't make enough healthy hemoglobin.
                
Genes control how the body makes hemoglobin protein chains. When these genes are missing or altered, thalassemias occur.
                
Thalassemias are inherited disordersthat is, they're passed from parents to children through genes. People who inherit faulty hemoglobin genes from one parent but normal genes from the other are called carriers. Carriers often have no signs of illness other than mild anemia. However, they can pass the faulty genes on to their children.
                
People who have moderate to severe forms of thalassemia have inherited faulty genes from both parents.
                
Alpha Thalassemias
                
You need four genes (two from each parent) to make enough alpha globin protein chains. If one or more of the genes is missing, you'll have alpha thalassemia trait or disease. This means that your body doesn't make enough alpha globin protein.
                
If you're only missing one gene, you're a "silent" carrier. This means you won't have any signs of illness.
                
If you're missing two genes, you have alpha thalassemia trait (also called alpha thalassemia minor). You may have mild anemia.
                
If you're missing three genes, you likely have hemoglobin H disease (which a blood test can detect). This form of thalassemia causes moderate to severe anemia.
                
Very rarely, a baby is missing all four genes. This condition is called alpha thalassemia major or hydrops fetalis. Babies who have hydrops fetalis usually die before or shortly after birth.
                
Example of an Inheritance Pattern for Alpha Thalassemia
                

                
Beta Thalassemias
                
You need two genes (one from each parent) to make enough beta globin protein chains. If one or both of these genes are altered, you'll have beta thalassemia. This means that your body wont make enough beta globin protein.
                
If you have one altered gene, you're a carrier. This condition is called beta thalassemia trait or beta thalassemia minor. It causes mild anemia.
                
If both genes are altered, you'll have beta thalassemia intermedia or beta thalassemia major (also called Cooley's anemia). The intermedia form of the disorder causes moderate anemia. The major form causes severe anemia.
                
Example of an Inheritance Pattern for Beta Thalassemia

Topic: Thalassemias
Source: NHLBI
Question: Who is at risk for Thalassemias? ?
Answer: Family history and ancestry are the two risk factors for thalassemias.
                
Family History
                
Thalassemias are inheritedthat is, the genes for the disorders are passed from parents to their children. If your parents have missing or altered hemoglobin-making genes, you may have thalassemia.
                
Ancestry
                
Thalassemias occur most often among people of Italian, Greek, Middle Eastern, Southern Asian, and African descent.

Topic: Thalassemias
Source: NHLBI