Public procurement notice: Voluntary Ex Ante Transparency Notice
Published: 2021-09-13
Buyer: Statens Serum Institut
Country: DK
Contract type: Supplies
Procedure: Negotiated without a prior call for competition
CPV classification: 33124000 | 33140000: Medical consumables | 33141000: Disposable medical supplies | 38430000
Estimated value: 2400000 DKK

Technical requirements: The Metabolomics Research Team at the Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening at Statens Serum Institut need a Q-Tof (Quadrupole time-of-flight) instrument with similar performance as our existing tims TOF Pro when used in high-resolution time-of-flight MS/MS mode.
The Metabolomics Research Team at the Section for Clinical Mass Spectrometry, Danish Center for Neonatal Screening at Statens Serum Institut aims at using HRMS (High Resolution Mass Spectrometry) metabolomics approaches to study biochemical underpinnings of health and disease in population-wide cohorts of biological samples (e.g. neonatal dried blood spots) stored at the Danish National Biobank.
The overall demand is that we need to collect high quality HRMS (High Resolution Mass Spectrometry) data of as many metabolites as possible in our un-targeted metabolomics projects.
For the identification of unknowns and verifications of knowns, we need as clean fragmentation spectra as possible. This will enhance the identification and verification. Verification is based on comparison with existing libraries and the identification of unknowns are based on comparison with results from (feature based) mass spectral molecular networking through GNPS in combination with manual interpretation of data. The software needs to be compatible with all GNPS workflows, including export of .mgf files from the software.
Today we are using a timsTOF Pro instrument for all our research projects and method development projects. The timsTOF Pro instrument has ion-mobility separation in combination with high-resolution time-of-flight mass spectrometry including fragmentation possibilities (MS/MS). The ion-mobility function can be turned on or off, and the instrument can be run in high-resolution time-of-flight MS/MS mode only.
Due to the complexity in the metabolomics research as the wide range of compounds the analysis would benefit with the possibility to use different methods, both chromatographic methods but also detection methods as different mode of ionization. Therefore, an investment in a second instrument would be of great support for our research and could be used either as run in parallel with our existing timsTOF Pro, for large cohort metabolomics projects, or used for method development and optimization while running metabolomics projects on the timsTOF Pro. The possibility to transfer optimized methods between the two instruments and to achieve the same results between the two instruments is crucial for the quality of the analysis and the statistical analysis of the metabolomics projects.
Data from the new instrument would need to be processed using MetaboScape in exactly the same way as data from our existing timsTOF Pro. MetaboScape was bought in combination with the timsTOF Pro and the software is compatible with library searching and uses automated workflows focused on matching with various libraries.
Two libraries, Bruker HMDB Metabolite Library and Bruker MetaboBASE Personal Library, were purchased in combination with the timsTOF Pro. They are both built of manually curated mass spectral MS/MS library consisting of more than 6000 MS/MS spectra for more than 800 compounds, Bruker HMDB Metabolite Library, and more than MS/MS spectra from over 100,000 isolated compounds, and in-silico generated MS/MS spectra for more than 233,000 compounds, Bruker MetaboBase Personal Library.
To be able to perform all the above the additional instrument can only be a Bruker Impact II mass spectrometer, a Q-Tof (Quadrupole time-of-flight) instrument with similar performance as our existing timsTOF Oro when used in high-resolution time-of-flight MS/MS mode.
Pursuant to Consolidated Act no. 593 of 2 June 2016 on the Complaints Board for Public Procurement as amended, the following time limits apply to the filing of requests for a review procedure:
Complaints about procurement procedures or decisions falling within Part II of the Danish Public Procurement Act which are not covered by subsection 1 of the Act, must, according to section 7(2) of the Act, be filed with the Danish Complaints Board for Public Procurement within:
(1) 45 calendar days of the contracting authority having published a notice in the Official Journal of the European Union to the effect that the contracting authority has entered into a contract. The time limit is calculated from the date after the date when the notice was published;
(2) 30 calendar days, calculated from the date after the date when the contracting authority notified the affected tenderers that a contract based on a framework agreement with reopening of competition or a dynamic purchasing system has been entered into, if the notification contained a statement of the reasons for the decision.
(3) six months of the contracting authority having entered into a framework agreement, counted from the date after the date when the contracting authority notified the affected candidates and tenderers, see section 2(2) of the Act, or section 171(4) of the Danish Public Procurement Act.


Winner: Bruker Nordic AB
Award value: 2400000