After a fourth place finish in the spring split, the team parted ways with head coach Zikz and hired Reapered as his replacement. Prior to the start of the summer split, 100 Thieves signed Abbedagge from the LEC, and Ry0ma was subsequently sent back to academy, while Damonte was dropped by the organization. The revamped roster would go on to finish second in the regular season, with a record of 29−16. The team won their first playoff match 3−2 against Evil Geniuses, before falling 2−3 to Team Liquid. In the losers' bracket, 100 Thieves defeated Cloud9 3−1 to set up a finals rematch against Team Liquid. This time around, 100 Thieves defeated Team Liquid in a 3−0 sweep, to win the 2021 LCS Championship and qualify for the 2021 League of Legends World Championship. The team's performance secured them a bye into Group B alongside China's Edward Gaming, Korea's T1, and Japan's DetonatioN FocusMe. The team finished third in their group, with a 3−3 record, and were eliminated from the tournament, placing 9th−12th overall and ending their season.