On Opening Day (April 2) in 2007, Rentería hit two home runs (including the game-winning one in the tenth) in a 5–3 victory over Philadelphia. He became the third Atlanta Brave to hit two home runs on Opening Day, joining Fred McGriff and Joe Torre. From April 20 to May 12, he had an eighteen-game hitting streak, which was the longest by a Brave in 2007. During the streak, he had four hits for the twentieth time in his career on April 27 in a 9–7 victory over Colorado. On May 15, he hit two home runs in a 6–2 win over the Nationals. He had four hits on May 30 in a 9–3 win over the Brewers. He had five hits for the first time since 2004 on June 16 in a 6–2 victory over the Indians. On August 3, he was placed on the disabled list for the first time since 1998 after he sprained his ankle the previous day. Rentería returned on August 22, but he returned to the DL a day later when he reinjured his ankle after facing only one pitch. He was activated again on September 7, and he returned to the Braves' lineup the next day. He finished the year with a .332 batting average (tied for third in the NL and a new career high), twelve home runs, and 57 RBI. He was one of only four major league shortstops in 2007 to bat over .300 with over ten home runs and fifty RBI (the others were Derek Jeter, Hanley Ramírez, and Miguel Tejada). However, because of the emergence of shortstop prospect Yunel Escobar, Rentería was traded to the Detroit Tigers on October 29 for Jair Jurrjens and Gorkys Hernández.