Chibiterasu and his various partners initially track down an evil summoner named  that gave rise to the curses across the lands. When Chibiterasu defeats King Fury, they find a stronger evil known as , who is seeking to curse the lands of Nippon. To do so, he must acquire the blood from Orochi, the eight-headed demon fought several times in the first game. Akuro travels back one year to when Amaterasu faced down Orochi; Chibiterasu follows it and prevents it from recovering the blood. Furious, Akuro travels back 100 years in time, when the swordsman Nagi and Shiranui, the wolf form that Amaterasu was later given, defeated Orochi. The team travel back in time to follow Akuro. Just before they enter Moon Cave, Kurow leaves the group, claiming to have found his 'True Mission'. The pup, saddened at Kurow's sudden departure, heads on into the cave to fight Akuro. Chibi, however, is unable to prevent Akuro from obtaining the blood this time, as Kurow, who has apparently turned evil and become Akuro's servant, stops Chibiterasu's efforts. Chibiterasu and his other allies follow Akuro to the dark realms where they find the demon has taken up residence in the body of Kuni and that Kurow intends on fighting the pup. Chibiterasu is forced to fight his former partner, expelling Akuro's spirit and freeing Kuni, but evil Kurow willfully allows it to take his body. However, this has been Kurow's plan all the time; he reveals he is a living doll of Waka, with the goal to house Akuro's spirit, such that if he is killed with Akuro inside him, Akuro would be dispelled. Chibiterasu, fighting back tears, complies with Kurow's instructions, and Akuro is destroyed forever. Kurow, just before his death, is sad about how he was nothing but a doll, however, the others reassure him that it was his adventures with Chibiterasu that made him who he was. It was these adventures that made him more than just a doll. Kurow dies happily, surrounded by friends. Afterwards, the remainder of Chibiterasu's partners return to their homes, more confident in their abilities; Kuni leaves home to seek out who he really is, much to Susano's regret. Chibiterasu joins with Issun to return to the Celestial Plain to reunite with Waka and Amaterasu.