Giguère began her collegiate career with the Clarkson Golden Knights during the 2017–18 season. During her freshman season, Giguère recorded 27 goals and 44 assists, setting Clarkson's program record for freshman scoring with 71 points. She was named the HCA National Rookie of the Month in December and March. She was also named the ECAC Hockey Rookie of the Month in October, December, January, and March. During the 2018 NCAA National Collegiate Women's Ice Hockey Tournament, she recorded the game-winning goal in overtime to send Clarkson to the Frozen Four. During the National Championship game against Colgate, she again recorded the game-winning goal in overtime, helping lead Clarkson to their second consecutive NCAA Tournament championship. Following the tournament, she was named to the 2018 Frozen Four All-Tournament team. Following an outstanding freshman season, she was named to the ECAC Hockey All-Rookie Team, ECAC Hockey First Team All-League, ECAC Hockey Rookie of the Year, and a Second-Team All-American.