Borne was a candidate for Renaissance (formerly known as La République En Marche!) in the 2022 French legislative election in Calvados's 6th constituency in the Normandy region in northwestern France. While remaining a candidate, under the dual mandate (cumuls des mandats) law she was not allowed to take up the position after she won the election, and was be replaced by her designated alternate. She called on voters to support Macron's coalition, Ensemble Citoyens, saying it is the only group "capable of getting [a parliamentary] majority". After the first round, in relation to contests between left-wing and far-right candidates, she said: "Our position is no voice for the RN." At the same time, she expressed support only for left-wing candidates who in her view respect republican values. She was elected to Parliament in the second round. Borne offered her resignation as prime minister after the results of the second round, but was rejected by Macron, who instead tasked her to form a new cabinet.