Borne is a candidate for Renaissance (formerly known as La République En Marche!) in the 2022 French legislative election in Calvados's 6th constituency in the Normandy region in northwestern France. While remaining a candidate, under the dual mandate (cumuls des mandats) law she will not be able to take up the position if she wins the election, and will be replaced by a designated alternate. She called on voters to support Macron's coalition, Ensemble Citoyens, saying it is the only group "capable of getting [a parliamentary] majority". At party headquarters, she told supporters: "In the face of extremes, we are the only ones who offer a project of coherence, clarity and responsibility. With the situation of the world and the war at Europe's doors, we cannot take the risk of instability and approximations." After the first round, in relation to contests between left-wing and far-right candidates, she said: "Our position is no voice for the RN." At the same time, she expressed support only for left-wing candidates who in her view respect republican values. She was elected to Parliament in the second round.