TrialPanorama/TrialPanorama-database huggingface dataset:
Primary endpoint: distal movement of maxillary molars and central incisors
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: root resorption of maxillary teeth
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: patient experiences and quality of life
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: Consumer perceptions of the meal
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Time invariant components of EEG signals
Endpoint domain: Physiological/clinical
Endpoint subdomain: Nervous system outcomes
Primary endpoint: Time of first request of analgesia
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: SPM signature profile/Resolution Index
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Median duration of fasting
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Percentage of parents who followed the preoperative fasting instructions
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: American Orthopaedic Foot and Ankle Society ankle-hindfoot score
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Hamilton Rating Scale of Depression (HAM-D)
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: Signal Intensity Change of a Lymph Node
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: motability
Endpoint domain: Life impact
Endpoint subdomain: Physical functioning
Primary endpoint: Number of Sick Days taken
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: Latency To Persistent Sleep
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Infections with fever
Endpoint domain: Adverse events/effects
Primary endpoint: Resolution time of intraretinal cysts and sub retinal fluid
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Changes in transfer capacity
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Incidence of infectious postoperative complications
Endpoint domain: Adverse events/effects
Primary endpoint: Session Rating of Perceived exertion
Endpoint domain: Life impact
Endpoint subdomain: Fatigue
Primary endpoint: Exclusive Breast Feeding Rate
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: NEC onset
Endpoint domain: Adverse events/effects
Primary endpoint: Follicular growth pattern on ultrasound scan
Endpoint domain: Physiological/clinical
Endpoint subdomain: Reproductive system and breast outcomes
Primary endpoint: Two-year All-cause Mortality
Endpoint domain: Mortality/survival
Primary endpoint: Incidence of COVID-19 infection
Endpoint domain: Physiological/clinical
Endpoint subdomain: Infections and infestations outcomes
Primary endpoint: Severity of COVID-19 infection
Endpoint domain: Physiological/clinical
Endpoint subdomain: Infections and infestations outcomes
Primary endpoint: Histological response to neo-adjuvant chemo-radiotherapy
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: 2 years global recurrence rate
Endpoint domain: Mortality/survival
Primary endpoint: Percentage of Participants Achieving ACR 50 Response
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Percentage of Participants Achieving ACR 70 Response
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Marijuana Craving Visual Analog Scale (VAS)
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Systolic blood pressure
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Efficacy of Cannabidiol (CBD) for reducing marijuana seeking
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Change of glucose metabolism
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Annual percentage use of diagnostic imaging before appendectomy
Endpoint domain: Resource use
Endpoint subdomain: Other resource use
Primary endpoint: Change in alveolar bone
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Upper limb function evolution
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change from Baseline in Social Functioning
Endpoint domain: Life impact
Endpoint subdomain: Social functioning
Primary endpoint: Change from Baseline in Role Functioning
Endpoint domain: Life impact
Endpoint subdomain: Role functioning
Primary endpoint: Perioperative Outcomes
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: Fitness level assessment
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Central diastolic and systolic blood pressures
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Number of Participants With Serious or Non-serious Adverse Events
Endpoint domain: Adverse events/effects
Primary endpoint: safety and efficacy of hemodiafiltration
Endpoint domain: Physiological/clinical
Endpoint subdomain: Renal and urinary outcomes
Primary endpoint: Intraoperative blood pressure
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Percent injected radioactivity dose per kilogram (% ID/kg) in the colon and plasma
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Standardized uptake value (SUV) in the colon
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Magnitude of HIV-1 insert-specific cellular responses
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Magnitude of Ad-specific cellular responses
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Adverse Events (AE) Reporting
Endpoint domain: Adverse events/effects
Primary endpoint: Pain measurement using Visual Analogue Scale (VAS)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Quality of neonatal resuscitation
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: In vivo IL-1 gene expression
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Ex vivo IL-1 production
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Ex Vivo Contact Angle
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Proportion of oro-tracheal intubations requiring third-party assistance
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: Number of contacts
Endpoint domain: Resource use
Endpoint subdomain: Other resource use
Primary endpoint: Endothelial Function as Indicated by the Reactive Hyperemia Index Score
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Change from baseline Doses of GDMT
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change from baseline Left Ventricular Ejection Fraction
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Number of Transfused Allogeneic Blood Units
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Predictive biomarker for response to regorafenib
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Voiding Efficiency
Endpoint domain: Physiological/clinical
Endpoint subdomain: Renal and urinary outcomes
Primary endpoint: Change in HbA1c from Baseline to Week 24
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Mean Difference in Generalized Anxiety Disorder -7 (GAD-7)
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: Adherence: Session(s) Attendance
Endpoint domain: Life impact
Endpoint subdomain: Role functioning
Primary endpoint: Compliance Level: Number of Active and Passive Tests Conducted
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Satisfaction Questionnaire Score
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Cmax of Venetoclax + Navitoclax
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: AUC of Venetoclax + Navitoclax
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Tmax of Venetoclax + Navitoclax
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: CL/F of Venetoclax + Navitoclax
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Area under the serum concentration-time curve from time 0 extrapolated to infinity [AUC(INF)]
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Total body clearance (CLT/F)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: CPB-induced coagulopathy
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Incidence of CHD and other lifestyle related diseases
Endpoint domain: Mortality/survival
Primary endpoint: Changes in abdominal fullness/bloating sensation
Endpoint domain: Physiological/clinical
Endpoint subdomain: Gastrointestinal outcomes
Primary endpoint: Shift in bacterial community
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Clinically administered PTSD Scale-5 (CAPS-5)
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: changes in the characteristics of the subbasal corneal plexus
Endpoint domain: Physiological/clinical
Endpoint subdomain: Nervous system outcomes
Primary endpoint: Line Loss of More Than Two Lines for Best Spectacle Corrected Visual Acuity (BSCVA)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Baseline clinical features of patients with HTLV infection
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Imaging studies results in patients with HTLV infection
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Immunological markers in patients with HTLV infection
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Viral studies results in patients with HTLV infection
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of CD34+ collected per body weight after the last LP
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Number of New HIV/HCV Diagnoses
Endpoint domain: Mortality/survival
Primary endpoint: Adherence to Care
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: Fractional Clearance rate of ABeta peptide in CSF
Endpoint domain: Physiological/clinical
Endpoint subdomain: Nervous system outcomes
Primary endpoint: Overall change in attitude towards vaccines
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Intent to have their children vaccinated
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Plasma polyphenols
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Urinary polyphenols
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: EEG bereitschaftspotential areas and amplitudes
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in time-matched QTcF intervals
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Change in ASD Symptoms as measured by SRS-2
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of Participants With ≥30% Reduction in SRS Raw Score
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: CGI Improvement Scores of ≤ 2
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: The number of deaths of any cause
Endpoint domain: Mortality/survival
Primary endpoint: Fugl-Meyer test
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neurological outcomes
Primary endpoint: Decrease of the IBS-SSS questionnaire
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Number of Cases Postponed Due to Lack of Information
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: Compliance to prescribed intervention (objective assessment)
Endpoint domain: Life impact
Endpoint subdomain: Role functioning
Primary endpoint: Compliance to prescribed intervention (subjective assessment)
Endpoint domain: Life impact
Endpoint subdomain: Role functioning
Primary endpoint: Efficacy of vardenafil treatment
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Tolerability of vardenafil treatment
Endpoint domain: Adverse events/effects
Primary endpoint: clinical phenotypes
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Variation of Carotid Intima-media Thickness (IMT)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Vascular outcomes
Primary endpoint: Time to Recurrence
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Percentage of Participants With Zero Errors After 28 Days of Inhaler Use
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Percentage of Participants With Atleast One Error After 28 Days of Inhaler Use
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Types and numbers of Candida species isolated from denture base
Endpoint domain: Physiological/clinical
Endpoint subdomain: Infections and infestations outcomes
Primary endpoint: Proportion of respondents completing follow-up
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: SN-5 at one year post procedure
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of Patients Who Developed Acute Pancreatitis
Endpoint domain: Adverse events/effects
Primary endpoint: Number of Safety Lead-In Participants With Dose Limiting Toxicities (DLTs)
Endpoint domain: Adverse events/effects
Primary endpoint: therapy response of lung cancer and metastases
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Changes in patient's average speed
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Changes in patient's average distance
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Changes in patient's number of steps
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Changes in patient's steps height
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Pain, Enjoyment, General Activity (PEG)
Endpoint domain: Life impact
Endpoint subdomain: Physical functioning
Primary endpoint: percent of patients at or below their pre-trauma opioid daily dose
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Difference in DFT
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Post Operative Pain Rating
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Occurrence of Grade 3 or 4 toxicities
Endpoint domain: Adverse events/effects
Primary endpoint: Predicted Adult Height at Year 3
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Patient's Perception of Pain
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: serum 25-hydroxy-vitamin D level
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Efficacy of Irinotecan in refractory breast cancer
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neoplasms and related outcomes
Primary endpoint: Safety of Irinotecan in refractory breast cancer
Endpoint domain: Adverse events/effects
Primary endpoint: Disease activity in rheumatoid arthritis
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Severity of rheumatoid arthritis
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Progression of rheumatoid arthritis
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: total wound drain after operation
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: MMP-14 levels in PPROM
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: neopterin levels in PPROM
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: orosomucoid 1 levels in PPROM
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of cesarean sections
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: Number of operative vaginal deliveries
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: Proportion of patients who achieve a drug concentration >= 70 nM in contrast enhancing tumor tissue
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neoplasms and related outcomes
Primary endpoint: Area Under the Concentration-time Curve From Time 0 to Infinity (AUC0-∞)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Time to Maximum Observed Serum Concentration (Tmax)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of Participants With High Fever
Endpoint domain: Adverse events/effects
Primary endpoint: occurrence of suicide attempt
Endpoint domain: Adverse events/effects
Primary endpoint: local tumor recurrence
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neoplasms and related outcomes
Primary endpoint: brain response to reward anticipation
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Brain response during reappraisal task
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of Participants With HPA Axis Suppression - Serum Cortisol Concentration
Endpoint domain: Physiological/clinical
Endpoint subdomain: Endocrine outcomes
Primary endpoint: Adverse Events, Including Treatment Emergent Adverse Events (TEAEs)
Endpoint domain: Adverse events/effects
Primary endpoint: Pain on numeric rating scale
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: perfusion assessment
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: PRWE
Endpoint domain: Life impact
Endpoint subdomain: Physical functioning
Primary endpoint: HTLV-1 Proviral load
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Tissue oxygen saturation
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Time of return to baseline activity
Endpoint domain: Life impact
Endpoint subdomain: Physical functioning
Primary endpoint: Proportion of conversion or readmission to conventional hospitalization
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: Change in activated partial thromboplastin time (aPTT)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Change in international normalized ratio (INR)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Reliability of prognostic/diagnostic test based on IgM/IgG analysis
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in liver fibrosis score
Endpoint domain: Physiological/clinical
Endpoint subdomain: Liver outcomes
Primary endpoint: Cavernous artery diameter
Endpoint domain: Physiological/clinical
Endpoint subdomain: Vascular outcomes
Primary endpoint: Systolic velocity cavernous artery
Endpoint domain: Physiological/clinical
Endpoint subdomain: Vascular outcomes
Primary endpoint: Diastolic velocity cavernous artery
Endpoint domain: Physiological/clinical
Endpoint subdomain: Vascular outcomes
Primary endpoint: Overall toxicity incidence
Endpoint domain: Adverse events/effects
Primary endpoint: Dose-limiting toxicity and maximum tolerated dose (MTD)
Endpoint domain: Adverse events/effects
Primary endpoint: Soft tissue volume
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Need for additional radiology examinations
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: Percentage of Participants With Clinical Response at Week I-12
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Percentage of Participants With Clinical Remission at Week I-12
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Percentage of Participants With Clinical Remission at Week M-44
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Proportion of Subjects With Investigator Global Assessment Mod 2011 (Scalp) Score of Clear and Almost Clear With at Least 2-point Reduction From Baseline at Week 16
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: Percentage of Subjects With Major Adverse Cardiovascular Events
Endpoint domain: Adverse events/effects
Primary endpoint: Performance on the Coincident Timing task
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in mental health symptom scores
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Mental health treatment engagement
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: Change in functional impairment
Endpoint domain: Life impact
Endpoint subdomain: Physical functioning
Primary endpoint: Change in dose of daily drug consumption
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: incidence of DLT
Endpoint domain: Adverse events/effects
Primary endpoint: progression free survival of RP2D
Endpoint domain: Mortality/survival
Primary endpoint: Rate of Response (Complete Response or Partial Response)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes