TrialPanorama/TrialPanorama-database huggingface dataset:
Primary endpoint: Sunnybrook Facial Grading System
Endpoint domain: Physiological/clinical
Endpoint subdomain: Nervous system outcomes
Primary endpoint: Hause Brackman Facial Nerve Grading System
Endpoint domain: Physiological/clinical
Endpoint subdomain: Nervous system outcomes
Primary endpoint: Facial Disability Index
Endpoint domain: Life impact
Endpoint subdomain: Physical functioning
Primary endpoint: change from baseline in fasting blood-glucose at 1 month
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: change from baseline in fasting blood-glucose at 3 months
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: change from baseline in glycosylated hemoglobin change at 1 month
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: change from baseline in glycosylated hemoglobin change at 3 months
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Change in Number of CD8+ Inflammatory Cells in Bronchial Biopsy Tissue
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Incidence rate of implant loss
Endpoint domain: Adverse events/effects
Primary endpoint: Intestinal Permeability
Endpoint domain: Physiological/clinical
Endpoint subdomain: Gastrointestinal outcomes
Primary endpoint: Occurrence of Solicited Systemic Symptoms
Endpoint domain: Adverse events/effects
Primary endpoint: Occurrence of Unsolicited Symptoms
Endpoint domain: Adverse events/effects
Primary endpoint: Number of Subjects Spontaneously Reporting Any Serious Adverse Event
Endpoint domain: Adverse events/effects
Primary endpoint: Occurrence of Solicited Local Symptoms
Endpoint domain: Adverse events/effects
Primary endpoint: Falls and falls related injury rates
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in direct pulmonary artery systolic pressure (PASP)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Post Anesthesia Emergence Delirium
Endpoint domain: Adverse events/effects
Primary endpoint: Presence of H.pylori infection
Endpoint domain: Physiological/clinical
Endpoint subdomain: Gastrointestinal outcomes
Primary endpoint: Intensive Care length of stay
Endpoint domain: Resource use
Endpoint subdomain: Hospital
Primary endpoint: Development of lower extremity deep venous thrombosis
Endpoint domain: Adverse events/effects
Primary endpoint: Satisfactory response after surgical procedure for vitiligo
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Kirkpatrick level 3
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Time to 1 mm ST depression during exercise-stress testing
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: interleukine 6 (IL-6)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: tumor necrosis factor alfa (TNFα)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: C-reactive Protein (CRP)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: D-Dimer
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: fibrinogen
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Assessment of stress
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: Diagnostic accuracy of cardiac PET/MRI
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Prevention of Patients Requiring Surgery
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: accuracy of macroscopic classification
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: sensitivity of macroscopic classification
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: specificity of macroscopic classification
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Acute complication rate
Endpoint domain: Adverse events/effects
Primary endpoint: Heart Failure Hospitalization Rate
Endpoint domain: Resource use
Endpoint subdomain: Hospital
Primary endpoint: Complete resection of 18F-FDOPA PET tracer volume
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: Health Assessment Questionnaire
Endpoint domain: Life impact
Endpoint subdomain: Physical functioning
Primary endpoint: Short Form-36
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: Change in global cardiac perfusion
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Tendon Young's modulus
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Resistance to plantar flexion test
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Vertical countermovement jump
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Triple hop test
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Patient Clinical Status - Liver Transplant
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Patient Clinical Status - Death
Endpoint domain: Mortality/survival
Primary endpoint: Incidence of Wait List Drop Off
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: Fecal bacteria analysis
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in total nasal symptom score
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Plasma PK
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Lung penetration
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Mean Systolic BP and Diastolic BP
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Mean change on the Site-Rated Hamilton Anxiety Rating Scale
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: Amount of radioactivity recovered in urine and feces
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Amount of PF-00868554 in plasma, urine, and feces
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: PK parameters (AUClast, AUCinf, Cmax, Tmax, t1/2)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Occurrence of adverse drug reactions
Endpoint domain: Adverse events/effects
Primary endpoint: Objective sleepiness
Endpoint domain: Life impact
Endpoint subdomain: Sleep
Primary endpoint: Daily Steps Taken Per Day
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Percentage of patients achieving adequate heartburn or regurgitation relief
Endpoint domain: Physiological/clinical
Endpoint subdomain: Gastrointestinal outcomes
Primary endpoint: Concentration of stimulated c-peptide
Endpoint domain: Physiological/clinical
Endpoint subdomain: Endocrine outcomes
Primary endpoint: Bladder function
Endpoint domain: Physiological/clinical
Endpoint subdomain: Renal and urinary outcomes
Primary endpoint: Performance of the BioSticker wearable
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Sensitivity of the BioCloud-based algorithms
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Trans-diaphragmatic pressure
Endpoint domain: Physiological/clinical
Endpoint subdomain: Respiratory outcomes
Primary endpoint: Platelet-thrombus Formation
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Maximum tolerated dose (MTD)
Endpoint domain: Adverse events/effects
Endpoint subdomain: Any subdomain
Primary endpoint: Change in WOMAC scores from baseline
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in Visual Analogue Scale (VAS) pain scores from baseline
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Hepatic progression free survival
Endpoint domain: Mortality/survival
Primary endpoint: Change in Coronary Flow Reserve
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Completion of in-depth interview
Endpoint domain: Resource use
Endpoint subdomain: Other resource use
Primary endpoint: Mean change on the MADRS total score
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: glaucoma progression
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Total AUC of FACT-Gastric TOI
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: Number of Participants With Elevated Cytokines
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Hip Flexion Range of Motion (Symptomatic Side)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Musculoskeletal and connective tissue outcomes
Primary endpoint: Knee Flexion Range of Motion (Symptomatic Side)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Musculoskeletal and connective tissue outcomes
Primary endpoint: change in DLQI (Dermatology Life Quality Index) score
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: change in Skindex-29 score
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: change in ShortForm 36 score
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: change in EQ 5D score
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: change in EQ VAS (EQ visual analogue scale) score
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: Kidney knowledge assessment
Endpoint domain: Life impact
Endpoint subdomain: Cognitive functioning
Primary endpoint: Time to Recovery
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in Oxygenation
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in Diastolic Blood Pressure
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Change in Respiratory Rate
Endpoint domain: Physiological/clinical
Endpoint subdomain: Respiratory outcomes
Primary endpoint: Change in Temperature
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Quality of Life after endometriosis surgery
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: Pain levels after endometriosis surgery
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: General service readiness
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Basic surgery readiness
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: Comprehensive surgery readiness
Endpoint domain: Physiological/clinical
Endpoint subdomain: Surgical and medical procedures outcomes
Primary endpoint: days of healing
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: DNase activity level
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Arterial flow rate
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Number of subjects with seroprotective antibody titers (rSBA titers >= 8) 1 month after primary vaccination
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Number of subjects with seroprotective antibody titers (rSBA titers >= 8) prior to booster dose
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Number of subjects with seroprotective antibody titers (rSBA titers >= 128) 1 month after booster dose
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Number of patients attaining a platelet count ≥ 50,000 /mm3
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Clinically significant change in vital signs
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Clinically significant change in body weight
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Clinically significant change in physical examination findings
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Clinically significant change in laboratory test value
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Clinically significant change in electrocardiogram results
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Adenoma Detection Rate
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in energy balance
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Weight development
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Frequency of infection
Endpoint domain: Adverse events/effects
Primary endpoint: Number of Participants Reporting Grade 3 or Higher Treatment-emergent Adverse Events
Endpoint domain: Adverse events/effects
Primary endpoint: Change in Amount and Quality of Joint Engagement
Endpoint domain: Life impact
Endpoint subdomain: Social functioning
Primary endpoint: number of hours spent with the newborn baby
Endpoint domain: Life impact
Endpoint subdomain: Personal circumstances
Primary endpoint: Percentage of Participants in Each Clinical Status Category
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change From Baseline in Glycosylated Hemoglobin A1c (HbA1c) to Week 24
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Percentage of Patients With On-Treatment Adverse Events (AEs) up to Week 24
Endpoint domain: Adverse events/effects
Primary endpoint: Percentage of Patients Positive for Anti-Drug Antibodies (ADAs) to Exenatide up to Week 24
Endpoint domain: Adverse events/effects
Primary endpoint: Rate of antibiotherapies modified by general practitioners
Endpoint domain: Resource use
Endpoint subdomain: Need for further intervention
Primary endpoint: Change in the shoulder range of motion
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in grip strength assessed by hydraulic hand dynamometer
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Change in quality of life assessed by the EORTC QLQ-C30
Endpoint domain: Life impact
Endpoint subdomain: Global quality of life
Primary endpoint: Incidence of influenza
Endpoint domain: Adverse events/effects
Primary endpoint: Device and/or procedure related adverse events
Endpoint domain: Adverse events/effects
Primary endpoint: Mass formation
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neoplasms and related outcomes
Primary endpoint: Changes of Platelet function assay (PFA)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Changes of blood viscosity
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Diagnosis of unexpandable lung
Endpoint domain: Physiological/clinical
Endpoint subdomain: Respiratory outcomes
Primary endpoint: Thymus size measured by ultrasound
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Peripheral blood naive T-helper lymphocyte concentration
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: T-cell receptor excision circle (TREC) level in peripheral blood mononuclear cells (PBMC)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Natural Killer Cell Activity (NKA)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Immune system outcomes
Primary endpoint: Calculated Total Blood Loss
Endpoint domain: Physiological/clinical
Endpoint subdomain: Blood and lymphatic system outcomes
Primary endpoint: Change in serum LDL cholesterol
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Relapses with biotin
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Corneal Staining
Endpoint domain: Physiological/clinical
Endpoint subdomain: Ocular outcomes
Primary endpoint: Conjunctival Staining
Endpoint domain: Physiological/clinical
Endpoint subdomain: Ocular outcomes
Primary endpoint: Subjective Vision
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Change in skin moisture
Endpoint domain: Physiological/clinical
Endpoint subdomain: Skin and subcutaneous tissue outcomes
Primary endpoint: Change in skin condition
Endpoint domain: Physiological/clinical
Endpoint subdomain: Skin and subcutaneous tissue outcomes
Primary endpoint: Percentage of Participants Who Completed All 6 Sessions
Endpoint domain: Life impact
Endpoint subdomain: Role functioning
Primary endpoint: FEV1 area under the curve (AUC0-12)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Respiratory outcomes
Primary endpoint: Pearlin role overload measure (ROM)
Endpoint domain: Life impact
Endpoint subdomain: Role functioning
Primary endpoint: beta-amyloid protein deposition
Endpoint domain: Physiological/clinical
Endpoint subdomain: Nervous system outcomes
Primary endpoint: Reduction in Mean Number of Days of Cannabis Use Per Week
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: left atrial function change
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Progress of pancreatic cyst
Endpoint domain: Physiological/clinical
Endpoint subdomain: Gastrointestinal outcomes
Primary endpoint: Objective posturography
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of Participants who develop ovarian hyperstimulation syndrome
Endpoint domain: Adverse events/effects
Primary endpoint: Duration of each headache attack
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Proportion of patients with clinically significant changes in physical examinations
Endpoint domain: Adverse events/effects
Primary endpoint: Number of patients with changes in laboratory assessments
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of patients with changes in vital signs
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of patients with changes in ECG parameters
Endpoint domain: Physiological/clinical
Endpoint subdomain: Cardiovascular outcomes
Primary endpoint: Occurrence and severity of adverse events
Endpoint domain: Adverse events/effects
Primary endpoint: Proportion of subjects with local irritation of the nose or pharynx
Endpoint domain: Adverse events/effects
Primary endpoint: Hamilton Depression Rating Scale-24 Point Version (HDRS-24)
Endpoint domain: Life impact
Endpoint subdomain: Emotional functioning/wellbeing
Primary endpoint: Symptomatic relief from leiomyomata
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Severity of thermal artifact
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Depth of thermal artifact
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Induction failure or relapse
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: First Occurrence of Macro-vascular Event or Death
Endpoint domain: Mortality/survival
Primary endpoint: Densitometry
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Disturbance in parameters evaluated
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Occurrence of aGVHD
Endpoint domain: Adverse events/effects
Primary endpoint: Change in mean daily alcohol consumption
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Number of Sessions Attended
Endpoint domain: Resource use
Endpoint subdomain: Other resource use
Primary endpoint: Participant Program Satisfaction Scores
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: Child Behavior Checklist Scores (Internalizing Subscale)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: At least a 50% reduction in target joint pain PI-NRS score from baseline without using rescue drug
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Carbon dioxide arterial pressure (PaCO2)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Comparison of standard CF NPD protocol vs modified NPD protocol with Genistein
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Efficacy of sTNS on V1 branch of trigeminal nerve
Endpoint domain: Physiological/clinical
Endpoint subdomain: Nervous system outcomes
Primary endpoint: Efficacy of XL184 treatment
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: treatment-related changes detected by functional MRI
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neoplasms and related outcomes
Primary endpoint: Percent reduction in primary generalized tonic-clonic seizure rates
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neurological outcomes
Primary endpoint: Percent responders (>=50% reduction in PGTC seizure rate from baseline)
Endpoint domain: Physiological/clinical
Endpoint subdomain: Neurological outcomes
Primary endpoint: Subjects' global evaluation of improvement in seizure severity
Endpoint domain: Life impact
Endpoint subdomain: Perceived health status
Primary endpoint: 30 seconds chair stand test
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Quantitative mass of test substance per area of skin
Endpoint domain: Physiological/clinical
Endpoint subdomain: Skin and subcutaneous tissue outcomes
Primary endpoint: Preconceptional maternal serum folate level
Endpoint domain: Physiological/clinical
Endpoint subdomain: Metabolic and nutritional outcomes
Primary endpoint: Prevalence of LIPA gene mutations
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes
Primary endpoint: Serum Alkaline Phosphatase (AP)
Endpoint domain: Physiological/clinical
Endpoint subdomain: General outcomes