TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06440746

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Subcutaneous (SC) injections of OKZ 64 milligrams (mg) every 4 weeks (q4w), one injection of 0.4 millilitre (mL)
Description: Olokizumab is a sterile solution for subcutaneous injection in a 2-mL clear Type I glass vial, containing a target fill volume of 0.5 mL (for withdrawal of no less than 0.4 mL) of olokizumab drug substance at a concentration of 160 milligrams (mg)/mL.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: SC injections of Placebo every 4 weeks (q4w), one injection of 0.4 mL
Description: Placebo (sodium chloride 0.9 %) does not contain any active pharmaceutical ingredients. Placebo will be supplied in 2-mL, 5-mL, or 10-mL ampoules made of low-density polyethylene or polypropylene.
Study: NCT05967260

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: DailyDose Smart Snack app
Description: A decision support tool that predicts the likelihood of overnight low blood sugar based on current CGM and inputted exercise. App will recommend a snack at bedtime based on the minimum low glucose predicted and the time of the low glucose.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Dexcom G6 CGM
Description: A commercially available Continuous Glucose Monitoring system that utilizes a transmitter and sensor to measure sensor glucose levels that transmit to a smart phone app.
Study: NCT05384561

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Smell training
Description: For 12 weeks, morning and evening, smell four different odors or four odorless substances for a total of five minutes per session.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Smell training
Description: For 12 weeks, morning and evening, smell four different odors or four odorless substances for a total of five minutes per session.
Study: NCT04494113

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: Undergo biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo collection of tissue and blood samples

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Resection
Description: Undergo surgical resection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Triapine
Description: Given IV
Study: NCT06666764

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: NBO
Description: NBO will be conducted with inhalation of 100% oxygen.

Intervention type: OTHER
Group type: OTHER
Intervention: Control
Description: Best medical care
Study: NCT05211869

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: T1D-CATCH
Description: As defined by the CDC, a CHW is a frontline public health worker who is a trusted member of a community or who has a thorough understanding of the community being served, and leverages this unique position to link health systems, social services, and communities. CHWs engender trust with patients by having direct community and lived experience, offering specific support and empathy that may be difficult for other diabetes care professionals to provide. In addition, CHWs have firsthand understanding of cultural barriers to traditional western healthcare and can promote patient-centered culturally-relevant care. They enhance team-based care by helping providers with extra outreach, social needs management, time-consuming tasks, and aligning patient-provider priorities.~CHWs in this project will provide social needs assessment and management, introduction to diabetes technologies, and support for onboarding to technology.
Study: NCT06097637

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: underwater endoscopic mucosal resection
Description: underwater endoscopic mucosal resection achieves similar rates of complete resection with comparable safety, with lower rates of recurrence and fewer repeat procedures.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: hot snare polypectomy
Description: Current guidelines recommend preoperative hot snare polypectomy after preoperative saline injection, nylon ring, or metal clip ligation of the tip and pedicle of the polyps
Study: NCT06627179

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intravitreal Injection of Ultevursen
Description: Up to 4 doses over a 24-month period

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: No intervention, will not receive any active study intervention
Description: Sham-procedure (no experimental drug administered)
Study: NCT06727721

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mesenchymal stem cells with OCN-19
Description: The patient received mesenchymal stem cells with OCN-19 three times

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Mesenchymal stem cells
Description: Ordinary mesenchymal stem cells were given

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: albumin injection
Description: Placebo
Study: NCT06731049

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Treadmill-based Training Group
Description: The walking speed will start at 75% of the walking speed calculated from the 10-meter Walk Test at normal walking pace, and the treadmill training will begin at this speed. Every two weeks, the speed will increase by 5%, and by the end of the 8th week, it will reach 100% of the normal walking speed. The aim of gradually increasing the walking speed is to progressively make the motor component of the exercise more challenging. Throughout the 8 weeks, a body weight support system will be used, and the support from the treadmill bar will be gradually reduced.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dual-Task Treadmill-based Training Group
Description: In the Dual-Task Treadmill-based Training Group, the same walking training protocol as the Treadmill Training Group will be applied with added second tasks to create a dual-task walking protocol. The second tasks will consist of both cognitive and motor tasks. The difficulty of the tasks and the total duration of the dual-task training will be increased over time.
Study: NCT06720610

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vonoprazan 20 mg
Description: Vonoprazan PO, 20mg, once a day, 14 days.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Esomeprazole
Description: Esomeprazole PO, 40mg, once a day, 14 days
Study: NCT06729424

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Digital patient education program
Description: The education consists of 8 modules including main themes within osteoporosis, with content aiming to promote behavioural changes including psychoeducation and behavioural activation.
Study: NCT06738667

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupuncture
Description: Patients in the acupuncture group will receive treatment at specified acupoints, performed by acupuncturists with at least five years of experience. The acupoints include bilateral Hegu (LI4), Yanglingquan (GB34), and affected-side Jiache (ST6), Xiaguan (ST7), and Tinggong (SI19). Participants will lie supine, and the skin will be sterilized. Sterile stainless-steel needles (0.25 mm diameter, 40 mm length) will be inserted using a guide device and a self-adhesive pad. Needles will be manipulated for at least 10 seconds to induce Deqi. Participants will receive 30 minutes of acupuncture for twelve sessions (3 per week for 4 weeks).

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham treatment
Description: The Park Sham device will be used for the sham acupuncture group. To maintain blinding, the acupuncture ritual will be identical in both groups, with the following exceptions: patients in the sham group will receive noninvasive acupuncture at the same acupoints as the acupuncture group. Sham needles, which resemble real needles but are blunt and slide within their handles, will be applied using the Park Sham device, secured to the skin with a self-adhesive pad. The procedure of manipulation is the same as for acupuncture, but without Deqi.
Study: NCT06737328

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Submocosal instrumentation using a ultrasonic device (PEEK). Submucosal cleaning
Description: The treatment under study is professional non-surgical, submucosal debridement with ultrasonic instruments with PolyEther Ether Ketone (PEEK) tip followed by copious irrigation with sterile saline

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Submocosal instrumentation using a ultrasonic device (PEEK). Submucosal cleaning
Description: The treatment under study is professional non-surgical, submucosal debridement with ultrasonic instruments with PolyEther Ether Ketone (PEEK) tip followed by copious irrigation with sterile saline
Study: NCT06739798

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Exp Group
Description: Binocular Spectacle prescription are therapeutic tools used to correct refractive errors in visually impaired patients. They improve Visual acuity as well as other visual functions in Amblyopic and visual impairment patients. They stimulate weaker eye to generate visual impulse and stimulate visual cortex to improve stereopsis and fusion.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Control Group
Description: Patching therapy is a gold standard tool used world wide to correct visual acuity in amblyopic patients. This tool is used by occluding stronger eye with a patch or bandage or fogging lens and stimulating amblyopic eye to generate visual stimulus to motivate visual cortex.
Study: NCT06737991

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Range of motion exercises
Description: Range of motion Exercises, soft tissue massage, positioning to prevent pressure sores, stretch pole for 20 minutes
Study: NCT06739993

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Resonance frequency breathing with heart rate variability biofeedback training
Description: During training, a ball that expands (breathe in) and shrinks (breathe out) on the screen specified the breathing frequency goal to a value of six cycles per minute (five seconds inspiration, five seconds expiration). The HRV was visualized by new symbols varying in color depending on the respectively measured values, which appeared every ten seconds. When the participants achieved the specified breathing frequency, resulting in an increased sinus arrhythmia, the symbols appearing on the smartphone display were green. When the participants did not achieve the specified breathing frequency, the symbols appeared in yellow (non-significant deviation), orange (significant deviation), or red (very significant deviation). The participants were instructed to adjust their breathing frequency to reach emergence of as many green symbols as possible for the entire training session.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Anti-Stress program
Description: The mobile system eSense Pulse from Mindfield Biosystems is used for the digital anti-stress program. To do this, the participants put on a chest strap with a sensor and can start training via the eSense app. The anti-stress program is carried out using a procedure generated for the study. During the anti-stress program units, the participants receive application-related information and tips to better understand the topic of stress, identify stressors in their own lives and reduce stress. The active control intervention of the anti-stress program was selected to investigate the effect of a specific stress level reduction without the direct modulation of physiological mechanisms of action as with HRV-BF-RFA.
Study: NCT06740994

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: conventional landmark paramedian technique
Description: a blind landmark scanning will be done and skin marking of the best palpable spinous process will be made.~the site of injection will be determined by palpation. continuous spinal anesthesia will be performed via paramedian approach.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: preprocedural ultrasound guided midline technique
Description: a preprocedural ultrasound scanning will be done, and skin marking of the best quality space will be made.~the site of injection and the insertion angle of the needle will be determined by ultrasound.~continuous spinal anesthesia will be performed via midline approach.
Study: NCT06741033

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Conventional physiotherapy
Description: Conventional physiotherapy of medial knee osteoarthritis patients: Isometric exercises, strengthening exercises, stretching exercises and electrotherapy.

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Toe-in gait modification
Description: A specific alteration in walking pattern where the toes are directed inward during walking. This modification should be clearly defined, including the degree of inward rotation of the foot and how it is taught and monitored in participants. Toe-in gait modification basically includes decrease foot progression angle from baseline through internal foot rotation. Participants are instructed to increase the Toe-in angle of their study limb by 5 degree and walk at least 5-10 minutes (progressed to 15-20 min after 4 week) with this progression angle.
Study: NCT06738719

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CT-P13 SC Auto-Injector
Description: Subcutaneous(SC) Injection

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Auto-Injector
Description: Subcutaneous(SC) Injection
Study: NCT06738056

Intervention type: DEVICE
Intervention: Nerivio
Description: Remote electrical neuromodulation (REN) device for the acute treatment of migraines. The device delivers transcutaneous electrical stimulation to the upper arm to induce conditioned pain modulation (CPM) that activates a descending endogenous analgesic mechanism. The treatment is self-administered and controlled by a smartphone application
Study: NCT04904042

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Use of plasma of neutral argon
Description: Evaluation of the mesentery or peritoneum area infiltrated by miliary implants that is going to be treated. Determination of the PCI. Collection of several samples of the mesenteric peritoneum or parietal peritoneum with tumor involvement (implants between 1-2.5mm of diameter).~It will established a matrix which will be divided into 12 quadrants where the tissue with implants will be placed and it will be treated according to specific power (80-100%), and for an action time of 2-4 seconds or until macroscopic tumor destruction. For each power, application of Plasmajet at 1, 2 and 3 cm from the target tumor tissue.~The in-vivo effect will be evaluated with the use of ball-tip in terms of damage to the serosa or vascularization of the mesentery.
Study: NCT05661136

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Warm air blower
Description: Lower body blanket with warm air blower set at 44 deg c started after spinal anesthesia when patient placed in supine/left lat position

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control: Lower body blanket not attached to warm air blower
Description: Control: Lower body blanket placed, not attached to warm air blower
Study: NCT06359249

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: change of habits
Description: change of habits

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: change of habits + auto abdominal massage
Description: change of habits + auto abdominal massage
Study: NCT04245124

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Strategic Memory Advanced Reasoning Training
Description: SMART focuses on three metacognitive strategies: Strategic Attention, Integrated Reasoning and Innovation.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Traditional Cognitive Rehabilitation
Description: Participants randomized to the TCR condition will participate in a clinician-directed intervention that provides manualized, traditional clinician-directed cognitive rehabilitation that was developed for the SCORE trial (Cooper et al., 2017)
Study: NCT05014074

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Theater/Pilot Testing
Description: Participants will take part in a theater/pilot testing in order to receive adequate feedback and make substantive change in the intervention
Study: NCT05636085

Intervention type: DEVICE
Intervention: Mainz Biomed Colorectal Cancer Screening Test
Description: There is no intervention.
Study: NCT06367153

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 1569912
Description: BI 1569912

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: repaglinide
Description: repaglinide

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: midazolam
Description: midazolam

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: bupropion
Description: bupropion
Study: NCT04901026

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: An in-house manikin
Description: Participants obtain an in-house manikin

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: An in-house manikin
Description: Participants obtain an in-house manikin
Study: NCT04645797

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: APR003
Description: This portion of the study further explores the clinical activity, safety, pharmacokinetics and pharmacology of APR003 monotherapy at the RP2D and to assess the antitumor activity of APR003 in subjects with unresectable CRC with liver metastases.
Study: NCT05882006

Intervention type: OTHER
Intervention: gallstones
Description: fellow up if the patients have gallstones

Intervention type: OTHER
Intervention: gallstones
Description: fellow up if the patients have gallstones
Study: NCT04869124

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dapagliflozin
Description: Dapagliflozin propanediol (FORXIGA) tablet: 10 mg once daily p.o. on top of recommended standard therapy, duration of administration: 12 weeks.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablet, matching Dapagliflozin, once daily p.o. on top of recommended standard therapy, duration of administration: 12 weeks.
Study: NCT05978414

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Visceral therapy
Description: Visceral therapy will be performed manually by a physiotherapist, a detailed description of the techniques is above. Therapy will be in 2 subgroups with prolapse of the usual genitals and endometriosis.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will be in 2 subgroups that will not have visceral therapy. The placebo will consist of the physiotherapist holding hands on the patient's pelvis.
Study: NCT06158477

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JYP0035 Experimental Drug Treatment
Description: Single dose intervention
Study: NCT06740019

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JMKX000197
Description: for pleural perfusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JMKX000197
Description: for pleural perfusion

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Tube thoracostomy drainage
Description: Tube thoracostomy drainage
Study: NCT06741150

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NWRD09 administered by intramuscular injection
Description: Intramuscular injection administration was carried out according to the protocol design.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NWRD09 administered by intramuscular injection
Description: Intramuscular injection administration was carried out according to the protocol design.
Study: NCT06403345

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Green Activity Program
Description: See arm description.
Study: NCT06566196

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cardiac Cath
Description: Patient will undergo standard of care Cardiac Cath and in addition invasive CPET (Cardiopulmonary exercise testing) will be performed during the procedure.
Study: NCT06272058

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Avenciguat (BI 685509)
Description: Avenciguat (BI 685509)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Avenciguat (BI 685509)
Description: Avenciguat (BI 685509)
Study: NCT04729478

Intervention type: DEVICE
Group type: OTHER
Intervention: Drug-induced sleep endoscopy
Description: An intravenous bolus injection of midazolam 1.5 mg will be used to induce sleep. Maintenance of sedated sleep will be obtained by a target-controlled infusion of propofol (2.0-3.0 µg/mL).

Intervention type: DEVICE
Group type: OTHER
Intervention: Natural sleep endoscopy
Description: Endoscopy during natural sleep.
Study: NCT05956184

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Intrauterine Device Insertion
Description: All womens will be placed in a gynecological position and underwent a bimanual examination to better determine whether the uterus was in the anteverted or retroverted position. Subsequently, a speculum will be inserted, and the cervix will be disinfected with betadine. In the conventional method: the anterior lip of the cervix is grasped and pulled with Pozzi forceps, and after entering the uterine cavity with a hysterometry the IUD is inserted. In the direct method: the anterior lip of the cervix is grasped and pulled with Pozzi forceps, and without using hysterometry the IUD is directly inserted. The strings will be cut approximately 2-3 cm after the cervix, and the Pozzi forceps and speculum will be removed. The accuracy of the IUD placement will be confirmed using pelvic ultrasound. The process will take about five minutes.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Intrauterine Device Insertion
Description: All womens will be placed in a gynecological position and underwent a bimanual examination to better determine whether the uterus was in the anteverted or retroverted position. Subsequently, a speculum will be inserted, and the cervix will be disinfected with betadine. In the conventional method: the anterior lip of the cervix is grasped and pulled with Pozzi forceps, and after entering the uterine cavity with a hysterometry the IUD is inserted. In the direct method: the anterior lip of the cervix is grasped and pulled with Pozzi forceps, and without using hysterometry the IUD is directly inserted. The strings will be cut approximately 2-3 cm after the cervix, and the Pozzi forceps and speculum will be removed. The accuracy of the IUD placement will be confirmed using pelvic ultrasound. The process will take about five minutes.
Study: NCT04628832

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PMP Use Mandate Letter
Description: A letter with reminders about the mandate to check the PMP when prescribing opioids.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Prescribing Information Letter
Description: A letter with information about the prescriber's patients who received co-prescriptions. The letters will provide clinical background on the harms of co-prescribing and encourage prescribers to avoid co-prescribing in the future.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Prescribing Information + PMP Use Mandate Letter
Description: A letter combining the content of the PMP Use Mandate Letter and the Prescribing Information Letter. This letter will remind prescribers about the PMP use mandate and provide information about the prescriber's patients who received co-prescriptions.