TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04575662

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: STAR Treatment
Description: Radiation therapy that delivers non-invasive, image-guided, precise high-dose of radiation to targets reducing dose exposure to adjacent normal tissue and minimizing the treatment toxicity.
Study: NCT06274359

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital storytelling
Description: Caregivers will receive text messages with embedded digital stories and messaging to encourage influenza vaccination.
Study: NCT05280015

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: microbiotherapy (GynMDD)
Description: multi-target microbiotherapy add-on venlafaxine

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: placebo add-on venlafaxine
Study: NCT04391868

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Viagra Tablet
Description: 50 mg tablet on Day 1 of each period

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sildenafil Citrate ODF
Description: 50 mg ODF on Day 1 of each period

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sildenafil Citrate ODF
Description: 50 mg ODF on Day 1 of each period
Study: NCT06512766

Intervention type: DRUG
Intervention: Hydroxychloroquine
Description: Patients in this group were treated with hydroxychloroquine (HCQ), a systemic medication commonly used as a first-line treatment due to its ease of use and established safety profile. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.

Intervention type: DRUG
Intervention: Hydroxychloroquine
Description: Patients in this group were treated with hydroxychloroquine (HCQ), a systemic medication commonly used as a first-line treatment due to its ease of use and established safety profile. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.

Intervention type: DRUG
Intervention: Methotrexate
Description: This group consists of patients treated with methotrexate (MTX), a systemic medication often used as a second-line treatment for its effectiveness in reducing inflammation and controlling autoimmune responses. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.

Intervention type: DRUG
Intervention: Methotrexate
Description: This group consists of patients treated with methotrexate (MTX), a systemic medication often used as a second-line treatment for its effectiveness in reducing inflammation and controlling autoimmune responses. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.

Intervention type: DRUG
Intervention: Cyclosporine A
Description: Patients in this group were treated with cyclosporine A (CsA), a potent immunosuppressive agent used for its effectiveness in controlling severe inflammatory responses. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.

Intervention type: DRUG
Intervention: Cyclosporine A
Description: Patients in this group were treated with cyclosporine A (CsA), a potent immunosuppressive agent used for its effectiveness in controlling severe inflammatory responses. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.

Intervention type: DRUG
Intervention: Retinoids
Description: This cohort includes patients treated with retinoids, which are used for their ability to modulate cell growth and differentiation. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.

Intervention type: DRUG
Intervention: Retinoids
Description: This cohort includes patients treated with retinoids, which are used for their ability to modulate cell growth and differentiation. Due to the retrospective nature of the study, the dosage form, dosage, frequency, and duration of treatments varied among patients.
Study: NCT05757999

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Magnesium Sulphate
Description: A magnesium sulphate infusion (60 mg kg-1, total volume 100 ml, infusion rate 10 ml min-1) will be administered to patients 10 min. before induction of anesthesia.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: The patients will be pretreated with an intravenous 0.9% saline infusion (total volume 100 ml, infusion rate 10 ml min-1) 10 min before induction of anesthesia.
Study: NCT04871321

Intervention type: DRUG
Intervention: nab-paclitaxel plus gemcitabine-cisplatin
Description: - gemcitabine 800mg/m2 + cisplatin 25 mg/m2 + nab-paclitaxel 100mg/m2 on day 1 and day 8, every 21 days
Study: NCT06686095

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Group IPACK Block
Description: IPACK Block: Before the procedure, the patient is informed about the technique and written consent is obtained from the patient. The patient lies in the prone position. The linear USG probe is placed approximately 2-3 cm above the popliteal fossa and scanned distally to identify the femoral shaft and popliteal artery. If the femoral condyles are initially visualized, the probe is moved until the condyles disappear and the femoral shaft is identified as a straight line and hyperechoic. Color doppler can be used to identify the popliteal vessels. The peripheral block needle is advanced between the femoral shaft and the popliteal artery. After negative aspiration control, 15-20 mL of LA medication is injected here.
Study: NCT06686836

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Sinus lift augmentation with bone substitute (Bio-Oss)
Description: A maxillary sinus lift augmentation was performed with a lateral window approach that was filled with a bone substitute (Bio-Oss®) and covered with a collagen membrane (Bio-Guide®).At 4 months after sinus lift, a biopsy was taken and implants (Starumann®) were placed with submerged healing. After 6 months, the second surgical phase was performed and another biopsy was taken. The bone samples collected were analyzed histologically and histomorphometrically.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Open sinus lift surgery lift using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®(Geistlich AG, Wolhusen, Switzerland)) - L-PRF Block
Description: A maxillary sinus lift augmentation was performed with a lateral window approach that was filled using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®) and covered with a collagen membrane (Bio-Guide®) (L-PRF block).~L-PRF block will be performed as described by Cortellini et al. 2018. L-PRF membranes are cut into small pieces and mixed with Bio-Oss® at a ratio of 2 membranes / 0.5 g biomaterial. Pieces of the block will be removed and compacted in the sinus cavity until it is filled.~At 4 months after sinus lift, a biopsy was taken and implants (Starumann®) were placed with submerged healing. After 6 months, the second surgical phase was performed and another biopsy was taken. The bone samples collected were analyzed histologically and histomorphometrically.
Study: NCT06691399

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Oral care
Description: Oral care done twice daily with chlorhexidine oral care solution (concentration 1.2%)

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Oral care
Description: Oral care done twice daily with chlorhexidine oral care solution (concentration 1.2%)
Study: NCT05274451

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LYL797
Description: LYL797 is an autologous, genetically (Gen-R™) and epigenetically (Epi-R™) reprogrammed ROR1-targeted chimeric antigen receptor (CAR) T-cell therapy
Study: NCT06694506

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Biological Sample
Description: Clinical examination and blood test. The clinical examination and blood test are considered standard-of-care as they could be performed annually or bi-annually as part of an adult GHD follow-up. Subsequently, the data will be collected directly from the patient's chosen physician.
Study: NCT06694337

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: 300 mg Palmitoylethanolamide (PEA) Phytosome® (contain120 mg mg pure PEA)
Description: 300 mg Palmitoylethanolamide (PEA) Phytosome®

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: 450 mg Palmitoylethanolamide (PEA) Phytosome® (contain180 mg mg pure PEA)
Description: 450 mg Palmitoylethanolamide (PEA) Phytosome®

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Control group
Description: Placebo

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Control group
Description: Placebo
Study: NCT06688539

Intervention type: DRUG
Group type: OTHER
Intervention: Varenicline Pill
Description: In this study, all participants will be administered active medication for a 12 week treatment period. The standard dose titration schedule will be used, which includes 0.5 mg once per day (q.d.) on Days 1-3, 0.5 mg twice per day (b.i.d.) on Days 4-7, and 1.0 mg b.i.d. starting on Day 8. Dosing of 2.0 mg per day will be maintained for the next 11 weeks, for a total of 12 weeks of active treatment for all study participants.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Contingency management
Description: Contingency management procedures will be implemented and financial incentives will be provided at weekly visits contingent on e-cigarette abstinence verified through urinary qualitative cotinine (starting at Week 2). A set amount of $20 per study visit will be delivered based on a negative qualitative urinary cotinine result.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Counseling
Description: Psychosocial counseling will be administered by trained research staff leading up to the target quit date and throughout the study.
Study: NCT06687044

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Sleep restriction
Description: Go to bed before 23pm

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stimulation control
Description: Avoid drugs, alcohol, caffeine, and nicotine

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive therapy
Description: Listen to 30 minutes of soothing music every night for 8 weeks

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Sleep principles discussion
Description: The principles of sleep hygiene are discussed, but without the application of stimulus control or sleep restriction
Study: NCT06688175

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IMRT combined with lobaplatin-based concurrent chemotherapy
Description: IMRT combined with two cycles of lobaplatin-based concurrent chemotherapy
Study: NCT05564182

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: High intensity laser therapy
Description: HILT will be applied to the patients five times a week for a period of three weeks and one session per day for a total of 15 sessions by a physical therapy technician who is experienced in using a laser device (BTL-6000 high intensity laser 12 W, Stevenage, Hertfordshire, England). It will be used in the rotator cuff muscles area in two stages, Phase I and Phase II. For analgesic effect in phase I. Phase II will also be applied for the biostimulation effect.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Therapeutic Exercise
Description: Therapeutic Exercise As therapeutic exercise program; A multidisciplinary stroke rehabilitation program will be implemented in the presence of a specialist physiotherapist. In addition, a therapeutic exercise program including passive, actively supported and active ROM exercises, stretching, strengthening and mobilization exercises will be applied to all patients by physiotherapists according to the level of pain and limitation.It was planned to implement a total of 15 sessions 5 days a week for 3 weeks, for approximately 30 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Therapeutic Exercise
Description: Therapeutic Exercise As therapeutic exercise program; A multidisciplinary stroke rehabilitation program will be implemented in the presence of a specialist physiotherapist. In addition, a therapeutic exercise program including passive, actively supported and active ROM exercises, stretching, strengthening and mobilization exercises will be applied to all patients by physiotherapists according to the level of pain and limitation.It was planned to implement a total of 15 sessions 5 days a week for 3 weeks, for approximately 30 minutes.
Study: NCT05420987

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Jing Si herbal tea liquid packet
Description: Jing Si herbal tea includes eight Taiwan native-grown herbs: such as mugwort leaves, fish needle grass, Ophiopogon japonicus, platycodon, perilla leaves, chrysanthemum, and licorice

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Jing Si herbal tea liquid packet
Description: Jing Si herbal tea includes eight Taiwan native-grown herbs: such as mugwort leaves, fish needle grass, Ophiopogon japonicus, platycodon, perilla leaves, chrysanthemum, and licorice
Study: NCT06686212

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sensory re-education+ strengthening exercises+ kinesio taping
Description: Sensory re-education. Splinting: as constant maintained touch with wrist holding in neutral position for 15 minutes.~Topical anesthesia spray on affected area for 10 minutes. Massage: apply massage over sensitive areas with same speed and pressure, then the light pressure with cotton, velvet, terry cloth, polyester and wool over sensitive area for 10 minutes.~PNF using upper extremity (D2) pattern including shoulder extension, adduction, internal rotation, wrist and fingers flexed and wrist ulnar deviated. 10-15 repetitions for 5 minutes.~Strengthening exercises: wrist flexion and extension, supination and pronation, opposition, gripping, ball squeeze and fingers pinching against resistance. 10-15 repetitions of each exercise for 20 minutes.~Kinesio taping: Taping will be applied twice a week for 12 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Neural mobilization+ Strengthening exercises+ Kinesio taping.
Description: The median nerve is mobilized through wrist flexion and extension with elbow straight and palm facing up.~Wrist flexion and extension with elbow flexed to 90 degrees with palm facing up 10-15 repetitions.~Wrist flexors stretch with extended arm and palm facing down 10-15 repetitions. Straight fist: hold your hand up with fingers straight. Full fist: bend your fingers to form a full fist. Median nerve stretch and wrist extension exercises for 30 minutes. Free the bird exercises, busy bee flexion shape of Z exercises and wall stretch exercise. (10-15 repetitions) for 10 minutes.~Strengthening exercises: wrist flexion and extension, supination and pronation, opposition, gripping, ball squeeze and fingers pinching against resistance. 10-15 repetitions each for 20 minutes.~Kinesio taping: The taping will be applied twice a week for 12 weeks.
Study: NCT05019183

Intervention type: OTHER
Group type: OTHER
Intervention: Physical training
Description: The subjects will perform 6 indoor rower sessions (30 min each, on Day 1, 2, 3, 8, 9 and 10) with a target heart rate zone of 60%.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical training
Description: The subjects will perform 6 indoor rower sessions (30 min each, on Day 1, 2, 3, 8, 9 and 10) with a target heart rate zone of 60%.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual reality
Description: The subjects will be able to move freely in virtual environments while training on the indoor rower.

Intervention type: DEVICE
Group type: OTHER
Intervention: Single-photon emission computed tomography (SPECT)
Description: SPECT allows the measurement of cerebral perfusion, reflecting the global synaptic activity, via a 3D acquisition of 20 minutes, 15 minutes after injection of 740 MBq of radiotracers (ECD - Neurolite or HMPAo - Cerestab), with iterative reconstruction. The data will be processed at the voxel scale by the SPM12 software, with analysis of brain connectivity.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Single-photon emission computed tomography (SPECT)
Description: SPECT allows the measurement of cerebral perfusion, reflecting the global synaptic activity, via a 3D acquisition of 20 minutes, 15 minutes after injection of 740 MBq of radiotracers (ECD - Neurolite or HMPAo - Cerestab), with iterative reconstruction. The data will be processed at the voxel scale by the SPM12 software, with analysis of brain connectivity.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: Metabolomics
Description: This qualitative approach will aim to identify pathways that are not known (or have not been explored) to optimize the chances of detecting metabolites present depending on the group (physical activity coupled or not with VR). This method is favorable for biomarker discovery.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Metabolomics
Description: This qualitative approach will aim to identify pathways that are not known (or have not been explored) to optimize the chances of detecting metabolites present depending on the group (physical activity coupled or not with VR). This method is favorable for biomarker discovery.
Study: NCT06275165

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: acupressure
Description: In the experimental group, routine nursing care and acupressure (Neiguan and Zusanli points) were performed from the 1st to the 5th day after the postoperative transfer from the ward to the hospital room. Twice a day, 3 minutes each time, 12 minutes in total.
Study: NCT04232501

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cirvo Compression device
Description: Patients will wear Cirvo compression device during the surgery, after surgery and will be discharged to home with the device to wear at home as the per study protocol instructions.
Study: NCT06040567

Intervention type: OTHER
Intervention: Validity and reliability of outcome measures in polyneuropathy
Description: Patients will be tested, answer patient reported outcome measures, and wear accelerometer at baseline after 2-4 weeks and after 1-2 years.

Intervention type: OTHER
Intervention: Healthy controls
Description: Healthy controls will be tested, answer patient reported outcome measures, and wear accelerometer at baseline visit. There is no follow-up in the healthy control group.
Study: NCT05678790

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Passive Stretching
Description: Sustained passive stretching of hamstring, tendo-achilles, and adductors 10 (30 s, with three repetitions, five times per week)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mobilization
Description: Grade four mobilizations is a stretching motion performed at the talocrural joint with anterior-posterior gliding. Mobilization was performed once a day, 6 times a day, and 5 times a week, only on both deformed feet of the older sibling

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Muscle strengthening
Description: Abdominal muscle strengthening exercises were given to both siblings once a day, 10 times a day, 5 times a week. In the supine position, the patients were asked to lie on their knees with the knees flexed. The hip extensors were trained in the prone position on the bed by resisting hip extension

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Balance and Coordination
Description: The following exercises were applied 5 times a week, with 1o repetition once a day.~* Standing on one leg in front of the mirror,~* Tandem walking,~* Rhythmic Dynamic Stabilization,~* Swiss ball sitting (eyes open and closed),~* Counting the alphabet or numbers while marching
Study: NCT05044169

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Broncho-Vaxom
Description: administration for 6 months after remmission
Study: NCT04751331

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LPS
Description: Lipopolysaccharide (LPS) (0.8ng/kg of body weight; E. coli group O:113)
Study: NCT06690710

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: allogeneic engineered Gingival Fibroblasts (aeGF)
Description: single intra-articular injection of the study drug (aeGF) in the knee joint
Study: NCT06687837

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: autologous dopaminergic cell implantation
Description: Dopaminergic progenitor cells derived from autologous induced pluripotent stem cells will be injected into the brain in two cohorts of Parkinson's patients, one receiving low dose and the other high dose (4 and 8 million cells, respectively)
Study: NCT04751331

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: 0.9% saline administered as an intravenous bolus
Study: NCT05484986

Intervention type: OTHER
Intervention: A questionnaire with 47 items
Description: A form consisted of questions on introductory characteristics (age, sex, and class, among others), Big Five Inventory (BFI) to evaluate personality traits, and Management of Workplace Violence Competence Scale for Nursing Students in Areas of Clinical Practice.
Study: NCT06390618

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Aerobic Exercise (AE) Group
Description: A total of 24 sessions of aerobic exercise will be performed in 8 weeks, 3 days a week.~For aerobic exercise, a moderate intensity (50-60%) aerobic exercise program will be applied using the karvonen method. According to the aerobic exercise intensity karvonen method, the formula (Maximal Heart Rate (220-years) - Resting Heart Rate) x 50-60% + Resting Heart Rate) will be used. 1-4. week 50%, 5-8. Exercise intensity will be increased by 60% per week.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Combined Exercise (CE) Group
Description: In the combined exercise group, biopsychosocial exercise will be performed in addition to aerobic exercise.~In the combined exercise group, in addition to aerobic exercise (3, 8 weeks, 24 sessions of aerobic exercise per week), 16 sessions of biopsychosocial-based group exercise treatment will be performed 2 days a week for a total of 8 weeks.~BETY approach will be used in group exercise treatment.
Study: NCT05942274

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: We propose to validate these smartwatch ECG functions to support FDA submissions
Description: 1) Obtain a simultaneous recording of a Lead I (RA-LA) ECG from the Smartwatch and a clinical standard device (GE Cardiosoft ECG). Subsequent recordings will be acquired from the other models of the Smartwatch as well as a recording utilizing the FDA-cleared KardiaMobile.
Study: NCT05868967

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [14C]DWP14012
Description: Each subject will receive a single oral dose of \[14C\]DWP14012 suspension (containing approximately 40 mg/80 μCi \[14C\]DWP14012) under fasting conditions.