TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06554704

Intervention type: BEHAVIORAL
Intervention: Isometric hand grip test
Description: The five-minute heart rate variability and respiration rate will be measured for each condition including resting in supine, sitting and standing position, as well as the isometric hand grip test in supine, sitting and standing position.

Intervention type: BEHAVIORAL
Intervention: Isometric hand grip test
Description: The five-minute heart rate variability and respiration rate will be measured for each condition including resting in supine, sitting and standing position, as well as the isometric hand grip test in supine, sitting and standing position.
Study: NCT05561283

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Self-questionnaires
Description: Self-questionnaires on satisfaction, burn-out, depression, anxiety, relational skills and sleep quality
Study: NCT05944068

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: midfulness training
Description: For this study we chose for a mindfulness based intervention. Mindfulness is defined as the ability to notice and observe details about one's present internal and external environment with the goal of non-judgemental and non-elaborative awareness of cognitions, emotions and physical sensations. The goal of the mindfulness intervention will be to teach patients a way of coping with negative emotions without acting on them, letting patients take control of their disease related behaviour and come to better disease acceptance. Where medical treatments fail to take away all disabling symptoms, psychological interventions like mindfulness could offer patients a coping method through which symptoms are experienced as less disabling and patients regain their quality of life. This research may further strengthen the need for a multidisciplinary approach in patients with Crohn's disease.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: midfulness training
Description: For this study we chose for a mindfulness based intervention. Mindfulness is defined as the ability to notice and observe details about one's present internal and external environment with the goal of non-judgemental and non-elaborative awareness of cognitions, emotions and physical sensations. The goal of the mindfulness intervention will be to teach patients a way of coping with negative emotions without acting on them, letting patients take control of their disease related behaviour and come to better disease acceptance. Where medical treatments fail to take away all disabling symptoms, psychological interventions like mindfulness could offer patients a coping method through which symptoms are experienced as less disabling and patients regain their quality of life. This research may further strengthen the need for a multidisciplinary approach in patients with Crohn's disease.
Study: NCT05220501

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: MRI Targeted Biopsy
Description: All subjects will be biopsied no matter their arm randomization. In this group, MRI targets will be identified and sampled.
Study: NCT04971122

Intervention type: OTHER
Group type: OTHER
Intervention: Trendeleburg -5 degree,-10 degree,-15 degree
Description: Use a -5 or -10 or -15 degree trendelenburg position
Study: NCT06454682

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RJK002 Intrathecal injection
Description: Eligible subjects will receive a single intrathecal administration of investigational product with dose 6E13 vg/person, 1.2E14 vg/person, and 2.4E14 vg/person sequentially.
Study: NCT06450301

Intervention type: PROCEDURE
Intervention: Endometrial Biopsy
Description: An endometrial biopsy is the removal of a small piece of tissue from the endometrium, which is the lining of the uterus. Endometrial biopsies are commonly done to check for the window of implantation, to determine ovulation or for enhancing implantation (procedure called endometrial scratching). For this purpose, we will use a Pipelle catheter. This procedure is very common in gynecologic practice and~generally considered safe. In most of the cases this procedure is indicated for evaluation of irregular vaginal bleeding, vaginal bleeding in post-menopausal women and for infertility related problems (recurrent implantation failures for example).
Study: NCT05432895

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dynamic splint
Description: Device treats plantar fasciitis and replacing boot immobilization which is quite benign
Study: NCT06407336

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Contrast sensitivity
Description: Contrast sensitivity will be assessed by using two different techniques of refraction on is Cylinderical lens and other is Spherical equivalent

Intervention type: OTHER
Group type: OTHER
Intervention: Refraction
Description: Refraction will be performed and contrast sensitivity will be assessed to assess patient comfort level and compliance.
Study: NCT06172322

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NTQ1062 with Fulvestrant
Description: Drug: NTQ1062 tablet(s) ，PO，QD in cycles of 28 days (21 days on treatment followed by 7 days off treatment).~Drug: Fulvestrant Injection 500mg in a 28-day cycle.
Study: NCT05810376

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital-based physical activity intervention
Description: The digital behavioral program comprises goal planning, motivational messages and video calls, social support, and routine follow-up of weekly goals.
Study: NCT06450301

Intervention type: PROCEDURE
Intervention: Endometrial Biopsy
Description: An endometrial biopsy is the removal of a small piece of tissue from the endometrium, which is the lining of the uterus. Endometrial biopsies are commonly done to check for the window of implantation, to determine ovulation or for enhancing implantation (procedure called endometrial scratching). For this purpose, we will use a Pipelle catheter. This procedure is very common in gynecologic practice and~generally considered safe. In most of the cases this procedure is indicated for evaluation of irregular vaginal bleeding, vaginal bleeding in post-menopausal women and for infertility related problems (recurrent implantation failures for example).

Intervention type: PROCEDURE
Intervention: Endometrial Biopsy
Description: An endometrial biopsy is the removal of a small piece of tissue from the endometrium, which is the lining of the uterus. Endometrial biopsies are commonly done to check for the window of implantation, to determine ovulation or for enhancing implantation (procedure called endometrial scratching). For this purpose, we will use a Pipelle catheter. This procedure is very common in gynecologic practice and~generally considered safe. In most of the cases this procedure is indicated for evaluation of irregular vaginal bleeding, vaginal bleeding in post-menopausal women and for infertility related problems (recurrent implantation failures for example).
Study: NCT05912738

Intervention type: OTHER
Intervention: Interventional therapy
Description: Interventional therapy for postherpetic neuralgia includes nerve blocks, pulsed radiofrequency therapy, etc
Study: NCT05798091

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Supportive-expressive group therapy
Description: The intervention is based on the evidence-based supportive-expressive (SEGT) approach and was designed by an interprofessional team from psychiatry, social work, physiatry and occupational therapy, along with patient advisors. The SEGT approach fosters mutual support, promotes openness and emotional expression. It has been shown to yield improvements in anxiety, psychosocial functioning, health literacy, and social support in breast cancer survivors. This SEGT approach has been modified, in both content and process, to specifically address the needs of limb loss inpatients.
Study: NCT04762758

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: (RS)-baclofen, naltrexone hydrochloride and D-sorbitol
Description: oral fixed dose combination

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: liquid oral solution
Study: NCT05810376

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Patient education and exercise
Description: Patient education will include information on osteoarthritis, prognosis, pain management, importance of physical activity and exercise. The exercise program will include warm up, stretching and strengthening.
Study: NCT05150106

Intervention type: OTHER
Intervention: Clinical assessments of laryngeal function
Description: Participants will undergo acoustic, aerodynamic, respiratory kinematic, nasoendoscopic, and laryngeal EMG recordings, as well as real-time MRI of the upper airway for comprehensive characterization of shared and distinct features of laryngeal dystonia and voice tremor.

Intervention type: OTHER
Intervention: Clinical assessments of laryngeal function
Description: Participants will undergo acoustic, aerodynamic, respiratory kinematic, nasoendoscopic, and laryngeal EMG recordings, as well as real-time MRI of the upper airway for comprehensive characterization of shared and distinct features of laryngeal dystonia and voice tremor.

Intervention type: OTHER
Intervention: Clinical assessments of laryngeal function
Description: Participants will undergo acoustic, aerodynamic, respiratory kinematic, nasoendoscopic, and laryngeal EMG recordings, as well as real-time MRI of the upper airway for comprehensive characterization of shared and distinct features of laryngeal dystonia and voice tremor.
Study: NCT05363501

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IM Naloxone Injection
Description: Single 0.4 mg IM naloxone injection will be administered (1 mL of 0.4 mg/mL injection, into the gluteus maximus muscle using a 23-gauge needle).
Study: NCT05514275

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Endostatin and Capecitabine
Description: Patients received radiotherapy Combined With Endostatin(37.5mg/m2, continuous intravenous infusion for 120h, D-7, D8, D22, D36) and Capecitabine( 650 mg/m2 bid, orally, d1-21, every 3 weeks as a cycle for 17 cycles)
Study: NCT06231368

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CNCT19 CAR-T cell therapy
Description: CNCT19 was a second-generation CAR T-cell with scFv derived from clone HI19α and 4-1BB/CD3-ζ costimulatory domain.
Study: NCT05810376

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Patient education and exercise
Description: Patient education will include information on osteoarthritis, prognosis, pain management, importance of physical activity and exercise. The exercise program will include warm up, stretching and strengthening.
Study: NCT04905810

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azacitidine
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Decitabine
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Given PO
Study: NCT04915105

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Markers data from PBMCs
Description: Prescreen markers from patient individual PBMCs treating with streptococcus and different biologics.
Study: NCT02021474

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AGX-201
Description: Subcutaneous injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Subcutaneous placebo (Evan's solution = phenol 0.4%, isotonic sodium chloride).
Description: Subcutaneous injection
Study: NCT05345704

Intervention type: OTHER
Intervention: cardiopulmonary resuscitation (CPR)
Description: Data from observation and collected from simulation mannequin during simulated CPR of an infant and child.

Intervention type: OTHER
Intervention: cardiopulmonary resuscitation (CPR)
Description: Data from observation and collected from simulation mannequin during simulated CPR of an infant and child.
Study: NCT04172376

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Minimally invasive puncture aspiration plus rt-PA
Description: Stereotactic puncture aspiration to evacuate basal ganglion hematoma with use of thrombolytic agent

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Conservative medical treatment
Description: Drugs for symptomatic treatment such as hemostasis and nerve nourishing.
Study: NCT04290273

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: MED Test
Description: Participant is irradiated with several doses of UV light on small areas of the outer thigh. 24 hours later this area is visually inspected for erythema, and the minimal erythemal dose (MED) is determined.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: MED Test
Description: Participant is irradiated with several doses of UV light on small areas of the outer thigh. 24 hours later this area is visually inspected for erythema, and the minimal erythemal dose (MED) is determined.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wearing device
Description: Participants wear a portable erythema measurement device for 48 hours. The device shines light on the skin at frequent intervals and measures skin 'redness'. The device is removed by a technician after the 48 hours.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wearing device
Description: Participants wear a portable erythema measurement device for 48 hours. The device shines light on the skin at frequent intervals and measures skin 'redness'. The device is removed by a technician after the 48 hours.
Study: NCT05939700

Intervention type: DRUG
Intervention: Mavacamten
Description: Observational study of individuals exposed to at least 1 dose of mavacamten at any time during pregnancy and/or breastfeeding
Study: NCT05798091

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as usual
Description: All patients may be referred to social work and/or a psychiatrist to address their mental health needs. As well, members of the interprofessional team provide psycho-social supports where needed. The types of psycho-social supports provided to patients in the TAU condition will be documented (e.g., referral to psychiatrist, social worker, etc.).
Study: NCT05815862

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AL2846 capsule
Description: AL2846 is a multi-target tyrosine kinase inhibitor.
Study: NCT06096389

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 100 Drop Jumps
Description: 100 drop jumps from 60 cm height. Divided into 5 sets of 20 reps

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: 100 Drop Jumps
Description: 100 drop jumps from 60 cm height. Divided into 5 sets of 20 reps

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 100 Drop Jumps
Description: 100 drop jumps from 60 cm height. Divided into 5 sets of 20 reps

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Whey supplementation
Description: Consume whey protein isolate based on subjects' daily protein intake

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Carbohydrate supplementation
Description: Consume carbohydrate (isocaloric to whey)

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: House cricket supplementation
Description: Consume defatted house cricket powder based on subjects' daily protein intake
Study: NCT06234085

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: VCA feedback report available
Description: Access to feedback report described in the intervention
Study: NCT06127472

Intervention type: OTHER
Group type: OTHER
Intervention: Training in detection and diagnosis of ASD
Description: To improve detection and diagnosis of ASD the participating mental health institutes will be trained by the research group on how to detect and diagnose autism in older adults. The basis of the ASD training involves two separate training sessions. Part one focuses on recognition and detection of ASD, specifically in older adults, and will be offered to the entire teams of the participating centres. The second part of the training focuses on the diagnosis of ASD and as such is offered primarily to diagnosticians. Follow up will consist of monthly recurring options for online consultation during the entire project to discuss clinical cases by experts in ASD in older adults from PersonaCura, clinical centre of excellence for personality and developmental disorders in older adults (dr. A. Videler and R. Wilting).

Intervention type: OTHER
Group type: OTHER
Intervention: Training in detection and diagnosis of ASD
Description: To improve detection and diagnosis of ASD the participating mental health institutes will be trained by the research group on how to detect and diagnose autism in older adults. The basis of the ASD training involves two separate training sessions. Part one focuses on recognition and detection of ASD, specifically in older adults, and will be offered to the entire teams of the participating centres. The second part of the training focuses on the diagnosis of ASD and as such is offered primarily to diagnosticians. Follow up will consist of monthly recurring options for online consultation during the entire project to discuss clinical cases by experts in ASD in older adults from PersonaCura, clinical centre of excellence for personality and developmental disorders in older adults (dr. A. Videler and R. Wilting).

Intervention type: OTHER
Group type: OTHER
Intervention: PE program
Description: An adapted PE program for older adults with a recent diagnosis of ASD. The PE program consists of seven, two-hour group meetings on a weekly basis.

Intervention type: OTHER
Group type: OTHER
Intervention: PE program
Description: An adapted PE program for older adults with a recent diagnosis of ASD. The PE program consists of seven, two-hour group meetings on a weekly basis.
Study: NCT05437692

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: zimberelimab combined With concurrent radiotherapy and chemotherapy
Description: zimberelimab: 240 mg Q2W Intravenous drip，The maximum duration of medication shall not exceed one years; chemotherapy: Starting from the first week of radiotherapy and chemotherapy, cisplatin 40mg/m2 and paclitaxel 35mg/m2 were given intravenously for 30-60min; Radiotherapy: intensity modulated radiation therapy (IMRT) was used for external irradiation. The total dose of pelvic cavity and lymph drainage planning target area (PTV) was 45-50 gy/25-28f. The metastatic lymph nodes should be able to supplement or synchronously push 10-15 Gy; The internal irradiation was started within 2 weeks after the end of external irradiation treatment. The image-guided three-dimensional brachytherapy was used, and 30-40gy was added to make the total dose of point a reach 80-85 Gy, twice a week, 5-6gy each time. All radiotherapy was completed within 8 weeks.
Study: NCT05363501

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Naloxone Nasal Spray
Description: Single 4 mg intranasal naloxone spray will be administered in one nostril (0.1 mL of 4 mg/0.1 mL spray, based on the prescribing information and approved Instructions for Use).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 4 mg naloxone nasal swab administered in nostril

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 8 mg naloxone nasal swab administered in nostril
Study: NCT05013385

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Spesolimab
Description: Spesolimab

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT05451602

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HEC169096
Description: Multiple doses of HEC169096 during Phase 2；Oral dose of HEC169096 as determined during Phase 2.
Study: NCT06384300

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Financial Incentives
Description: In the financial incentive group, participants will receive reimbursement for transportation, accommodation, and food costs, along with RMB 200 (about 30 US dollar) to compensate for potential income loss due to endoscopy, provided they undergo the endoscopy.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Motivational Intervention
Description: For the motivational intervention group, researchers will provide detailed information about the social norms surrounding endoscopy screening, including the prevalence of screening participation, the potential risks of gastric cancer, and the health benefits of screening.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mixed Intervention
Description: Participants in the mixed intervention group will receive both financial incentives and motivational intervention.
Study: NCT05118750

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALTO-300 oral (PO) tablet
Description: One tablet daily
Study: NCT05751252

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ganirelix
Description: An intra-venous cannula will be inserted and blood will be sampled at 10-min intervals for a 4-h baseline period commencing at 0800 h. Ganirelix will be then administered subcutaneously at single-dose regimen at 0.0625 mg (n = 10 women with PCOS). After Ganirelix administration sampling will continue at 10-min intervals for 4 h.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ganirelix
Description: An intra-venous cannula will be inserted and blood will be sampled at 10-min intervals for a 4-h baseline period commencing at 0800 h. Ganirelix will be then administered subcutaneously at single-dose regimen at 0.025 mg (n = 10 women with PCOS). After Ganirelix administration sampling will continue at 10-min intervals for 4 h.
Study: NCT06358976

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Vibration plus anti-spastic hand splint
Description: vibration stimulation will be applied to the spastic hand antagonistic muscles using a volar anti-spastic hand splint and the Myovolt Arm vibrator.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Anti-spastic hand splint
Description: the use of anti-spastic hand splint alone.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Vibration
Description: The use of hand vibrator alone
Study: NCT05363501

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 8 mg naloxone nasal swab administered in nostril

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 12 mg naloxone nasal swab administered in nostril

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 12 mg naloxone nasal swab administered in nostril

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 12 mg naloxone nasal swab administered in nostril

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 12.5 mg naloxone nasal swab administered in nostril

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naloxone Nasal Swab
Description: 12.5 mg naloxone nasal swab administered in nostril
Study: NCT06521385

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Makani Science Respiratory Monitoring System
Description: Subjects monitored by the Makani Science Respiratory Monitoring System