Study: NCT06047093

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Investigation of the intrahepatic compartment using the fine needle aspiration (FNA) technique
Description: The FNA will be performed at the Croix Rousse digestive pathology day hospital of the Hospices Civils de Lyon by a doctor from the hepatology department who has been trained to perform FNA.~After echography, a subcutaneous anesthesia with LIDOCAÏNE is administered. Two FNA passages will be performed for virological and immunological analyses. The patient will be monitored in the supine position for 1 hour after the procedure.~A single FNA will be performed during the study.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Investigation of the intrahepatic compartment using the fine needle aspiration (FNA) technique
Description: The FNA will be performed at the Croix Rousse digestive pathology day hospital of the Hospices Civils de Lyon by a doctor from the hepatology department who has been trained to perform FNA.~After echography, a subcutaneous anesthesia with LIDOCAÏNE is administered. Two FNA passages will be performed for virological and immunological analyses. The patient will be monitored in the supine position for 1 hour after the procedure.~A single FNA will be performed during the study.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Investigation of the intrahepatic compartment using the fine needle aspiration (FNA) technique
Description: The FNA will be performed at the Croix Rousse digestive pathology day hospital of the Hospices Civils de Lyon by a doctor from the hepatology department who has been trained to perform FNA.~After echography, a subcutaneous anesthesia with LIDOCAÏNE is administered. Two FNA passages will be performed for virological and immunological analyses. The patient will be monitored in the supine position for 1 hour after the procedure.~A single FNA will be performed during the study.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Investigation of the intrahepatic compartment using the fine needle aspiration (FNA) technique
Description: The FNA will be performed at the Croix Rousse digestive pathology day hospital of the Hospices Civils de Lyon by a doctor from the hepatology department who has been trained to perform FNA.~After echography, a subcutaneous anesthesia with LIDOCAÏNE is administered. Two FNA passages will be performed for virological and immunological analyses. The patient will be monitored in the supine position for 1 hour after the procedure.~A single FNA will be performed during the study.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Investigation of the intrahepatic compartment using the fine needle aspiration (FNA) technique
Description: The FNA will be performed at the Croix Rousse digestive pathology day hospital of the Hospices Civils de Lyon by a doctor from the hepatology department who has been trained to perform FNA.~After echography, a subcutaneous anesthesia with LIDOCAÏNE is administered. Two FNA passages will be performed for virological and immunological analyses. The patient will be monitored in the supine position for 1 hour after the procedure.~A single FNA will be performed during the study.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Creation of a serum biobank
Description: 42ml blood sample for study of circulating peripheral blood mononuclear cells (PBMC) and new circulating hepatitis B markers. These samples will enable us to gain a better understanding of peripheral immune responses and to correlate intrahepatic virological data with new serum markers of HBV.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Creation of a serum biobank
Description: 42ml blood sample for study of circulating peripheral blood mononuclear cells (PBMC) and new circulating hepatitis B markers. These samples will enable us to gain a better understanding of peripheral immune responses and to correlate intrahepatic virological data with new serum markers of HBV.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Creation of a serum biobank
Description: 42ml blood sample for study of circulating peripheral blood mononuclear cells (PBMC) and new circulating hepatitis B markers. These samples will enable us to gain a better understanding of peripheral immune responses and to correlate intrahepatic virological data with new serum markers of HBV.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Creation of a serum biobank
Description: 42ml blood sample for study of circulating peripheral blood mononuclear cells (PBMC) and new circulating hepatitis B markers. These samples will enable us to gain a better understanding of peripheral immune responses and to correlate intrahepatic virological data with new serum markers of HBV.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Creation of a serum biobank
Description: 42ml blood sample for study of circulating peripheral blood mononuclear cells (PBMC) and new circulating hepatitis B markers. These samples will enable us to gain a better understanding of peripheral immune responses and to correlate intrahepatic virological data with new serum markers of HBV.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FNA feasibility and acceptability questionnaire
Description: An FNA feasibility and acceptability questionnaire carried out at inclusion (V1) and after the FNA has been performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FNA feasibility and acceptability questionnaire
Description: An FNA feasibility and acceptability questionnaire carried out at inclusion (V1) and after the FNA has been performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FNA feasibility and acceptability questionnaire
Description: An FNA feasibility and acceptability questionnaire carried out at inclusion (V1) and after the FNA has been performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FNA feasibility and acceptability questionnaire
Description: An FNA feasibility and acceptability questionnaire carried out at inclusion (V1) and after the FNA has been performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FNA feasibility and acceptability questionnaire
Description: An FNA feasibility and acceptability questionnaire carried out at inclusion (V1) and after the FNA has been performed.