TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06652321

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endothelial Side Up Femtosecond Laser Assisted DSAEK
Description: The Femto LDV Z8 laser system will be set to create a 100 μm thick graft with a 7.5 mm diameter.~The graft will be inverted, placed endothelial side up in the anterior chamber, and coated with Viscoat. A fixation ring will center the graft by holding the scleral rim with forceps.~After cutting, the cornea should remain endothelium-up, stained with Trypan Blue, and dissected using a blunt spatula. The graft will be placed on a Busin glide and coated with Viscoat.~A 3-4 mm corneal incision will be made, and Descemet's membrane will be marked and stripped. The graft will be inserted using the Busin glide, spreading automatically. A small air bubble will fill the anterior chamber to compress the graft for 10 minutes.
Study: NCT06652139

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: selinexor combined with BEAM regimen
Description: Selinexor: 60mg po D-10, D-7 and D-4 Carmustine: 300mg/m2 ivgtt D-8 Etoposide: 100mg/m2/d ivgtt q12h D-7-D-4 Cytarabine: 200mg/m2/d ivgtt q12h D-7-D-4 Melphalan: 140mg/m2 ivgtt D-3-D2

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: BEAM regimen
Description: Carmustine: 300mg/m2 ivgtt D-8 Etoposide: 100mg/m2/d ivgtt q12h D-7-D-4 Cytarabine: 200mg/m2/d ivgtt q12h D-7-D-4 Melphalan: 140mg/m2 ivgtt D-3-D2
Study: NCT06653348

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ticagrelor 60 + Aspirin
Description: Ticagrelor 90 mg BID plus ASA 80 mg daily for 1 month and then ticagrelor 60 mg BID plus ASA 80 mg daily until the end of month 3.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ticagrelor 90 + aspirin
Description: ticagrelor 90 mg BID plus ASA 80 mg daily for 1 month.
Study: NCT06651918

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: yoga practise
Description: For the experimental study, the researcher will contact the participants to be included in the study and the intervention (yoga group) and control groups will be randomly created. The participants will be informed about the study by the researcher and their voluntary consent will be obtained. The researcher will provide information about the Identifying Characteristics Form for Children Diagnosed with Cancer and Their Families, the Quality of Life Scale for Children (PedsQL) and the Memorial Symptom Assessment Scale to be used in the study. The survey and scales will be applied to each participant individually one day before yoga. Then, the Yoga Group will be applied 3 sessions per week, 3 weeks in a row, each session will be 30 minutes. The researcher will repeat the survey and scale questions that he asked the participants before they started yoga at the end of the 3 weeks.
Study: NCT05870527

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Electrical stimulator
Description: Electrical stimulation will be used to stimulate the Arnold's nerve and measure pupil dilation. The electrical stimulator is part of the standard facial nerve monitoring unit that we utilize in cochlear implantation and will be setup prior to surgery in standard fashion. The device allows for constant current stimulation, with stimulus range between 0-30 mA.
Study: NCT05761873

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Provision of audit and feedback via email and paper
Description: Provision of A\&F reports by paper via the post (new intervention being trialled) and email (standard practice) to allocated practices depending on randomisation status.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Provision of audit and feedback via paper only
Description: Provision of A\&F reports by email (standard practice in the region) to allocated practices depending on randomisation status.
Study: NCT05313945

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Passive indwelling urinary catheter removal
Description: After washing the patient's perineal area with water and mild soap, the nurse deflates the indwelling urinary catheter balloon and instructs the patient to take a shower (standing).~During this time, the catheter will fall under gravity.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Active indwelling catheter removal by a nurse
Description: After washing the patient's perineal area with water and mild soap, the nurse deflates the balloon and removes the catheter from the urethra by manual traction.
Study: NCT05910879

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self-Affirmation Implementation Intentions (SAII) Intervention
Description: In an brief exercise, participants are asked to provide a personal story and positive experience during the challenging and sometimes stressful COVID19 pandemic, ...a time when you felt successful and proud of yourself. ...You can also tell us about a time that you did something to help someone in need. The self-affirmation is designed to offset effects of threats to self. In the next section participants are asked to formulate an if-then plan with one preferred self-affirmation-inducing cognition: If I feel sad, threatened, or discriminated against, then I will... a)...think about things I value about myself, b)...remember things that I have succeeded in, c) ...think about what I stand for, or d)...think about things that are important to me. After selecting response, participants read the full If-Then plan out loud and are provided with a paper copy of their exercise to take home.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Promotores de Salud (Health Education)
Description: The Promotores de Salud intervention includes: (1) a culturally tailored health education to increase knowledge about COVID-19 and the benefits of testing; (2) motivational interviewing (MI) strategies to explore personal, social, and behavioral barriers to testing and to discuss available resources to resolve these barriers; (3) emotional support to address testing-related concerns and anxieties that may dissuade Latinx individuals from getting tested; and (4) service navigation. When promotores (community health advocates) are on-site at Mexican Consulate events, they will provide information about COVID-19 and preventive behaviors using in-person instruction on effective mask wearing, hand washing, and physical distancing, as well as the importance of repeated testing and vaccines.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Promotores de Salud (Health Education)
Description: The Promotores de Salud intervention includes: (1) a culturally tailored health education to increase knowledge about COVID-19 and the benefits of testing; (2) motivational interviewing (MI) strategies to explore personal, social, and behavioral barriers to testing and to discuss available resources to resolve these barriers; (3) emotional support to address testing-related concerns and anxieties that may dissuade Latinx individuals from getting tested; and (4) service navigation. When promotores (community health advocates) are on-site at Mexican Consulate events, they will provide information about COVID-19 and preventive behaviors using in-person instruction on effective mask wearing, hand washing, and physical distancing, as well as the importance of repeated testing and vaccines.
Study: NCT05185089

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Orvepitant Maleate
Description: Orvepitant tablets 30mg or 10mg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Orvepitant Maleate
Description: Orvepitant tablets 30mg or 10mg

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablets to match orvepitant 30mg and 10mg tablets
Study: NCT06516562

Intervention type: DRUG
Intervention: Optimal treatment
Description: Optimal treatment using current National Guidelines for the diagnosis and treatment of chronic heart failure
Study: NCT04950816

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: tailored MBI (.b)
Description: The session will include brief didactic presentations, videos, and mindfulness practice followed by inquiry. We anticipate that sessions will take place twice a week. Sessions will be held on site at the Covenant House Texas (CHT) shelter in a quiet, designated learning space to ease access to sessions for the participants and to assure access to shelter staff (e.g., social workers and case managers) and services (e.g., food and shelter). CHT has onsite, weekday clinical and mental health care and established protocols for accessing needed resources 24/7. Selection criteria for the interventionist include maintaining a personal mindfulness practice for at least two years, trained in .b, and prior experience working with high-risk youth. The interventionist will receive additional training in Trauma-Informed Care as well as study procedures.
Study: NCT05178849

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hypnosis
Description: Hypnosis

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Local anesthetic
Description: For the local anesthesic, the doctor uses in both arms of the study a 20 ml vial of lidocaine hydrochloride without adrenaline for injection dosed at 2%.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Local anesthetic
Description: For the local anesthesic, the doctor uses in both arms of the study a 20 ml vial of lidocaine hydrochloride without adrenaline for injection dosed at 2%.
Study: NCT04950816

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: attention control condition
Description: Participants will receive no training in MBI or meditation. Topics covered may include physical activity, nutrition, managing weight, understanding adolescence, personal care, avoiding tobacco, alcohol, and drugs though this will be finalized in YR-1 with the HYWG and advisory panel. The HT program will be led by a positive adult instructor with training in health education or a related field and experience working with YEH.
Study: NCT05785975

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Certain ommunications(Nudge), community-outreach(landline call), and single FIT testing
Description: The intervention is an integrated system made up of single FIT testing, community outreach (landline call), and specific messages (Nudge). In order to encourage people to attend the screening, a primary care physician will be used in addition to text messages that participants at the outreach get for information, education, and communication (IEC).
Study: NCT05293379

Intervention type: OTHER
Intervention: Connected teleconsultation booth
Description: 15-minutes assessment in a connected teleconsultation booth.
Study: NCT04430673

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home-School based VR system trial
Description: Commercially available VR games operated Raspberry pi micro computer and Oculus Quest VR headsets provided for 2 weeks at dose and intensity selected by participants.
Study: NCT05064475

Intervention type: DIAGNOSTIC_TEST
Intervention: PET/CT
Description: Patients with previous breast cancer, already treated and with clinical or biochemical suspicion of disease relapse. All patients will underwent 18F-fluorodeoxyglucose (FDG) PET/CT. In all patients, the value of CA 15.3 was compared to PET/CT. The final diagnosis of relapse will be derived from histopathological sampling As much as possible or radiological follow up for at least 6 months will be compared with PET/CT results.
Study: NCT06652061

Intervention type: DIAGNOSTIC_TEST
Intervention: Dual Energy X-Ray Absorptiometry Scan (DEXA Scan)
Description: A DEXA scan, or Dual-Energy X-ray Absorptiometry, is a specialized imaging technique used to measure Bone Mineral Density (BMD). It is commonly employed to diagnose osteoporosis and assess the risk of fractures, especially in areas prone to bone density loss, such as the spine, hip, and forearm. The scan works by using two low-energy X-ray beams that pass through the bone, allowing it to differentiate between bone and soft tissue and calculate the bone's density. DEXA is considered the gold standard for osteoporosis diagnosis due to its high accuracy and precision.~The DEXA scan is a non-invasive, out-patient and painless procedure. Patients lie on an examination table while the scanner passes over the targeted area, typically the hip and spine. The entire procedure is straightforward, taking around 10 to 30 minutes depending on the areas being scanned.

Intervention type: DIAGNOSTIC_TEST
Intervention: X-Ray (Hip and Spine)
Description: Hip and spine X-rays are specific types of radiographic imaging used primarily to evaluate bone health, joint integrity, and alignment in these crucial areas. In the context of osteoporosis assessment, hip and spine X-rays can reveal signs of bone thinning or fractures, serving as an initial screening tool before more detailed imaging like a DEXA scan. During a hip X-ray, the patient typically lies on an examination table with the hip positioned for a clear view of the pelvis and femur. In a spine X-ray, the patient's posture may vary, often lying on the table in either a supine or lateral position to capture views of the vertebrae in the lower back (lumbar spine). Patients may be asked to remain very still, or even hold their breath momentarily, to prevent motion blur, which can obscure important details. Both hip and spine X-rays are quick and painless, generally taking only a few minutes, with the X-ray exposure itself lasting less than a second.
Study: NCT06651320

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: The patients in the interventional arm will be introduced to video will be introduced to a concise, animated video explaining the steps they are about to undergo in the department, the OR, recovery
Description: The patients in the interventional arm will be introduced to video will be introduced to a concise, animated video explaining the steps they are about to undergo in the department, the OR, recovery and discharge. How to prepare for the procedure, what to expect during and after the procedure and what are the possible follow up scenarios.~In order to overcome language berries videos would be available in basic 6th grader language and translated into English, Arabic and Russian for the non-Hebrew speaking population.~There would be one staff member aware of the patient's allocation the international Vs nonintervention arm while the rest of the staff would be masked to the research arm the patient was allocated to.~Once they have watched the video they would be asked to fill up a questionnaire their anxiety level concerning the procedure (STAI-S).
Study: NCT06650735

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: BMR resection
Description: Lid speculum will be applied. Fornix conjunctival incision will be used to expose medial rectus muscle. Area that will be resected will be marked using calipers. Double-armed polyglactin 910 suture (6/0 Vicryl) will be used in securing the muscle.~The muscle then excised anterior to the sutures and the stump cut flush to the sclera.~The muscle will be sutured again to the original insertion by scleral sutures which will be tied together.~Conjunctiva will be closed using polyglactin 910 suture (6/0 Vicryl).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: BLR recession
Description: Lid speculum will be applied. Fornix conjunctival incision will be used to expose lateral rectus muscle. Double-armed polyglactin 910 suture (6/0 Vicryl) will be used in securing the muscle close to the insertion.~The muscle will then be cut anterior to the sutures flush with the sclera. Calipers will used to mark the new insertion on sclera measured from the stump. The muscle will be sutured again to the new insertion by scleral sutures, which will be tied together.~Conjunctiva will be closed using polyglactin 910 suture (6/0 Vicryl).
Study: NCT06019858

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Vitamin Energy Shot
Description: Vitamin Energy® shot is a naturally-caffeinated functional energy shot that contains:~Vitamin B3 Vitamin B6 Vitamin B12 Natural Caffeine (green tea extract) L-Carnitine Tartrate Potassium Sorbate Taurine Sucralose
Study: NCT06651242

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Decision-making information aids
Description: Provide a decision-making information aids to assist patients and their parents in treatment decision making.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Routine care
Description: Routine care
Study: NCT06651164

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: psychosocial risk screening
Description: * combined tablet-based screening questionnaire for psychosomatic screening and social service screening~* in case of positive psychosomatic or social service screening subsequent psychosomatic and / or social service consultation
Study: NCT05123807

Intervention type: OTHER
Group type: OTHER
Intervention: Cytoreductive surgery
Description: (an operation to remove as much tumor tissue as possible) with hyperthermic intraperitoneal chemotherapy
Study: NCT04922164

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Cue intervention
Description: Around 30 pieces of narrative information about how a mother behaves in specific decision context will be derived from our qualitative study to construct social normative cues.~For goal-related cues, words relating to each category of breastfeeding-related values, benefits and goals will be identified and used to construct the messages (e.g. attractive body shape, smart baby, natural, strong immunity and etc.). Each goal-priming message will be presented with brief priming words and a picture of an image of the desirable goal.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Cue intervention
Description: Around 30 pieces of narrative information about how a mother behaves in specific decision context will be derived from our qualitative study to construct social normative cues.~For goal-related cues, words relating to each category of breastfeeding-related values, benefits and goals will be identified and used to construct the messages (e.g. attractive body shape, smart baby, natural, strong immunity and etc.). Each goal-priming message will be presented with brief priming words and a picture of an image of the desirable goal.
Study: NCT04404192

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PH94B
Description: Intranasal administration of 100 microliters to each nostril 4 times a day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Intranasal administration of 100 microliters to each nostril 4 times a day.
Study: NCT05329441

Intervention type: BEHAVIORAL
Intervention: Trier Social Stress Test (TSST)
Description: In this mechanistic study, all participants will undergo a modified version of the Trier Social Stress Test (TSST), which is a well-validated psychosocial stress paradigm, adapted for adolescents that involves no deception and is considered a very mild stressor. The TSST comprises of two stress tests: a 5-minute arithmetic task and a 5-minute speech task. Due to repeated testing of the TSST, participants will be randomized to one task at T1 and complete the second task at T2 (counterbalanced design). Every 5 minutes, participants will provide ratings of their mood using a visual analogue scale (1-10) of eight mood states (Afraid, Confused, Sad, Angry, Energetic, Tired, Happy, and Tense) that will be used as potential behavioral responses to social stress. Glutamate and inflammation outcomes will be examined acutely and from T1 and T2.
Study: NCT04828551

Intervention type: DEVICE
Group type: OTHER
Intervention: Ultrasound based shear wave speed and fat quantification methods
Description: Ultrasound based imaging parameters will be collected from all patients in two visits. These will include but may not be limited to SWE results, Quantitative ultrasound parameters,where available,including Attenuation Coefficient, Backscatter Coefficient, Shear Wave Dispersion, Speed of Sound, Ultrasound derived fat fraction Conventional Bmode (gray-scale) and Doppler ultrasound images,including An image of the liver and right kidney on the same image for hepatorenal index calculation Right liver lobe for skin to liver capsule distance calculation Portal vein Doppler for portal vein pulsatility index measurement VCTE and Controlled Attenuation Parameter measurements with the Fibroscan system

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Blood collection
Description: Blood will be collected by trained phlebotomists at each site using routine methods and standard collection tubes.~Total volume is expected to be about 10 mL or less Blood collected at MGH will be analyzed by the MGH clinical laboratory. Blood collected at UCSD will be analyzed by the UCSD clinical laboratory. Blood results obtained within the 3-month interval prior to the screening visit at the MGH or UCSD laboratories will be considered acceptable for study analyses and may be used at PI discretion. For each laboratory, the normal ranges for each blood test will be recorded and filed

Intervention type: OTHER
Group type: OTHER
Intervention: Physical measurements
Description: Height will be recorded at Screening. Weight and vital signs will be recorded at each visit. Body mass index will be calculated at each visit. All measurements will be made by trained coordinators using standard and calibrated instruments.

Intervention type: OTHER
Group type: OTHER
Intervention: Clinical history and medication reviews
Description: The following questionnaires will be administered at Screening:~Medical history questionnaire Medication use questionnaire Alcohol consumption questionnaire Physical activity questionnaire~The following questionnaires will be administered at Visit 1 and Visit 2:~Interim medical history questionnaire Change in medication use questionnaire Change in alcohol consumption will be recorded using a modified version of the alcohol use followback. Alcohol use for the 7 day period prior to Visit 1 and for all days between Visit 1 and Visit 2 will be recorded. Change in physical activity questionnaire
Study: NCT03957343

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Pacing and Planning App
Description: Participants will download and use the Pacing and Planning app through mybrainpacer.ca. The app will be used to track and monitor their daily tasks and symptoms at any time, for as long as they would like to use the app. While using the app, participants will also fill out short assessments, including the Rivermead Post-Concussion Questionnaire once a month (to monitor symptoms) and an overall symptom question once a week (to rate how they feeling in general from a lot better to a lot worse).
Study: NCT06384859

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: ESWT
Description: Receive ESWT once a week for 4 weeks

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ESWT
Description: Receive ESWT once a week for 4 weeks

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PRP
Description: Receive PRP injection at week 5
Study: NCT05795283

Intervention type: DRUG
Intervention: Citalopram i.v. and p.o
Description: Citalopram:~i.v.: 10 mg/die for day 1-7, 20 mg/die for day 8-14 p.o.: 20 mg/die for day 15-28

Intervention type: DRUG
Intervention: Citalopram p.o
Description: Citalopram:~p.o: 10 mg/die for day 1-7, 20 mg/die for day 15-28
Study: NCT04175392

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Align Probiotic Supplement Capsule
Description: Align Probiotic 1 billion units, 1 capsule once daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebos
Description: Placebos capsule 1 capsule Once daily