TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05441163

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: APA and nutrition intervention
Description: - APA intervention: weekly supervised sessions at home with the APA professional combined with unsupervised sessions, alone or with the APA partner, for 8 weeks.~The supervised session will be broken down as follows: warm-up block (approximately 10'), aerobic block (15'), muscle strengthening/resistance block (15') and stretching/relaxation block (10'). The remaining 10' will be used to review the session and the individual sessions. This program can be adapted to the needs and abilities of the patient if necessary.~- Nutritional intervention: dietitian weekly visits at home during 8 weeks with dietetic counseling; decision of oral, enteral and/or parenteral feeding validated by the clinical steering committee according to the Société Francophone de Nutrition Clinique et Métabolisme (SFNCM) guidelines.
Study: NCT06432088

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Extended Magnetic Grasper Device
Description: The purpose of this study is to evaluate the safety and effectiveness of the Extended Magnetic Grasper Device in patients undergoing bariatric and/or hiatal hernia procedures, as a liver retractor grasping the liver and/or the tissue surrounding the crus of the diaphragm.
Study: NCT05889273

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ML-004 (IR)/(ER) tablet
Description: Participants will receive ML-004 once daily.
Study: NCT06267560

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TQJ230
Description: TQJ230 80mg QM s.c.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: matching placebo
Study: NCT05130437

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-3927
Description: mRNA-3927 dispersion for IV infusion
Study: NCT06402864

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: contact X-ray brachytherapy (CXB)
Description: 3 fractions of contact X-ray brachytherapy (CXB) every two weeks before neoadjuvant chemo radiotherapy (nCRT).
Study: NCT04572815

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Administration
Description: Given IV and SC

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Quality-of-Life Assessment
Description: Ancillary studies

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Quality-of-Life Assessment
Description: Ancillary studies

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaire Administration
Description: Ancillary studies

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Questionnaire Administration
Description: Ancillary studies

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ustekinumab
Description: Given IV and SC
Study: NCT05911295

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: disitamab vedotin
Description: Given into the vein (IV; intravenous) every 2 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: pembrolizumab
Description: 400mg given by IV every 6 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: gemcitabine
Description: 1000 mg/m\^2 given by IV on days 1 and 8 of every 3-week cycle

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: cisplatin
Description: 70 mg\^2 given by IV on day 1 of every 3-week cycle

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: carboplatin
Description: Area under the plasma concentration-time curve (AUC) 4.5 or 5 given by IV on day 1 of every 3-week cycle
Study: NCT06324344

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: High-Dose TENS
Description: high-dose TENS device delivers 1 hour of TENS therapy per session.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Low-Dose TENS
Description: low-dose TENS device delivers 6 minutes of TENS therapy per session.
Study: NCT05572138

Intervention type: DIAGNOSTIC_TEST
Intervention: Body Impedance Analysis
Description: Body Impedance Analysis
Study: NCT06653855

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dry Static Cupping
Description: A myofascial decompression cupping set with a precision pressure pump will be used to perform dry static cupping to the adductor and hamstring muscle groups of the affected limb, using a negative pressure of 300mmHg for eight minutes each.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Placebo cupping
Description: The same protocol will be used as stated for the Dry static cupping intervention, with the only difference being that the cup will be pumped to 50mmHg instead of 300mmHg.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard physical therapy treatment
Description: Treatment will consist of typical physical therapy interventions performed for patients with spasticity of the lower extremity after stroke. These may include, but not be limited to:~* Balance exercise~* Therapeutic exercise~* Neuromuscular/muscular coordination exercise~* Manual (hands on) therapy~* Gait training~The treating physical therapist is left with the autonomy of the standard physical therapy treatment (within the above stated groups of interventions) because patients with the diagnosis of stroke do not all present with the same type or level of impairment. Furthermore co-morbidities (e.g., hypertension) and/or functional level (wheelchair bound vs. independent ambulator) may necessitate different treatment strategies. Therefore, while the general categories of treatment will remain the same across all study patients, it is expected that the treating physical therapist provides patient-specific interventions.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Standard physical therapy treatment
Description: Treatment will consist of typical physical therapy interventions performed for patients with spasticity of the lower extremity after stroke. These may include, but not be limited to:~* Balance exercise~* Therapeutic exercise~* Neuromuscular/muscular coordination exercise~* Manual (hands on) therapy~* Gait training~The treating physical therapist is left with the autonomy of the standard physical therapy treatment (within the above stated groups of interventions) because patients with the diagnosis of stroke do not all present with the same type or level of impairment. Furthermore co-morbidities (e.g., hypertension) and/or functional level (wheelchair bound vs. independent ambulator) may necessitate different treatment strategies. Therefore, while the general categories of treatment will remain the same across all study patients, it is expected that the treating physical therapist provides patient-specific interventions.
Study: NCT04893616

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Integration of vaccination services into delivery services
Description: The purpose of the work is to integrate readily available birth dose vaccinations (Oral Polio and the Tuberculosis vaccine) currently given in a separate clinic into the maternity delivery services through improved training, checklist, and job aides.
Study: NCT06593886

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: BabyG
Description: This involves wearing a harness connected to the overhead device while in a 10 X 10 play area filled with toys and equipment commonly used for infants to promote mobility skills (e.g. crawling and walking). Families can choose to come for 3 30-minute or 2 45-minute sessions per week. Half of the children will participate in the training immediately after enrollment in the study, the others will wait for 12 weeks before starting training. All will receive a comprehensive assessment at 0, 12 and 24 weeks, with additional developmental assessments at 6 and 18 weeks

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: BabyG
Description: This involves wearing a harness connected to the overhead device while in a 10 X 10 play area filled with toys and equipment commonly used for infants to promote mobility skills (e.g. crawling and walking). Families can choose to come for 3 30-minute or 2 45-minute sessions per week. Half of the children will participate in the training immediately after enrollment in the study, the others will wait for 12 weeks before starting training. All will receive a comprehensive assessment at 0, 12 and 24 weeks, with additional developmental assessments at 6 and 18 weeks
Study: NCT05962853

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental group (Transcutaneous Electrical Nerve Stimulation)
Description: The application will be applied at 8 hour intervals in the first 24 hours after the surgery.
Study: NCT04974060

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Remifentanil Injection
Description: Dilute 2mg Remifentanil with normal saline to 50 ml (40ug/ml) and continuously intravenous infused at the doses of 0.02, 0.04, 0.06, and 0.08 μg/kg/min for each lasting 30 minutes.
Study: NCT06666491

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tafenoquine
Description: A single dose of TQ will be administered orally on Day 1 or Day 2.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Primaquine
Description: A single dose of PQ will be administered orally, daily, on Day 1 or 2 to Day 14 (or Day 15 if PQ started on Day 2).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Chloroquine
Description: A single dose of CQ will be administered orally, daily, on Days 1 to 3.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chloroquine
Description: A single dose of CQ will be administered orally, daily, on Days 1 to 3.
Study: NCT06666179

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: low dose SCB-1019T
Description: Bivalent Recombinant Respiratory Syncytial Virus (RSV) Vaccine (CHO Cell) (SCB-1019T)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: adjuvanted low dose SCB-1019T
Description: Bivalent Recombinant Respiratory Syncytial Virus (RSV) Vaccine (CHO Cell) (SCB-1019T)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: high dose SCB-1019T
Description: Bivalent Recombinant Respiratory Syncytial Virus (RSV) Vaccine (CHO Cell) (SCB-1019T)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: adjuvanted high dose SCB-1019T
Description: Bivalent Recombinant Respiratory Syncytial Virus (RSV) Vaccine (CHO Cell) (SCB-1019T)

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% NaCl saline placebo

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% NaCl saline placebo
Study: NCT04685824

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Biofeedback Training
Description: Audiovisual stimulation

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Biofeedback Training
Description: Audiovisual stimulation

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Immersive Virtual-Reality
Description: Audiovisual stimulation
Study: NCT05961943

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: RESPONSE-2-PAD
Description: The RESPONSE-2-PAD program will undergo evaluation through a pilot study includes 50 patients living with peripheral arterial disease. Participants will take part in an initial assessment which will measure their sedentary time/physical activity using activPAL and their six-minute walking distance. They will then take part in a 12-week tailored, coaching-based intervention delivered remotely. The intervention involves the use of an activity tracker (sedentary reminder) and an online structured education program coupled with coaching calls that review sedentary time and activity goals weekly. At 12-weeks all participants will be invited to a follow up assessment. Participants will also be invited to take part in a semi-structured interview to explore their views and opinions of the program and its acceptability. At six months all patients will be invited for a final follow-up measurements.
Study: NCT06665607

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Intrinsic Mucle Training
Description: Conventional physiotherapy treatment and the intrinisc foot muscles strengthening program for 8 weeks.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intrinsic Mucle Training
Description: Conventional physiotherapy treatment and the intrinisc foot muscles strengthening program for 8 weeks.
Study: NCT04980300

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention
Description: Participants in the Intervention arm will receive five virtual consultation sessions, delivered by a physical therapist over 12 weeks (at Weeks 1, 2, 4, 7, and 10) and lasting approximately 45-60 minutes each. Each session will focus on lower extremity strengthening exercises, physical activity (i.e., walking), and education about knee osteoarthritis. Participants will be provided with an exercise manual, tracking log, educational manual, and a step counter. Participants will be prescribed up to 6 exercises (quadriceps, hip abductor/gluteal, hamstrings/gluteal, calf, balance) and daily walking step goals. Progression will be a joint decision by the participant and physical therapist. Education will include information on knee osteoarthritis, managing pain, being active, weight loss, dealing with setbacks, and progressing activity. The physical therapist will also discuss barriers and facilitators to meeting and progressing goals as appropriate.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Participants in the Control arm will receive access to a study-specific website that navigates them to a variety of web-based resources on knee osteoarthritis. Topics for the various resources include an overview of knee osteoarthritis, brief anatomy of the knee and how that is related to pain, different types of arthritis pain and how to manage it, and how to be active with arthritis. Sessions range from 20 - 70+ minutes.
Study: NCT06670963

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iron
Description: Iron derisomaltose 0.2g IV if reticulocyte hemoglobin equivalent \<29.3 pg (lower limit for the local laboratory reference range for reticulocyte hemoglobin equivalent)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: EPO
Description: Epoetin alfa 50 units/kg IV 3 times weekly

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: 0.9 % NaCl
Description: Volume of 0.9% NaCl identical as volume of medications used in experimental arm
Study: NCT05910138

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Serum Interlukin-15
Description: Evaluate its serum level and detect its relation to the activity and severity of Alopecia Areata.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Serum Interlukin-15
Description: Evaluate its serum level and detect its relation to the activity and severity of Alopecia Areata.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Serum Interlukin-21
Description: Evaluate its serum level and detect its relation to the activity and severity of Alopecia Areata.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Serum Interlukin-21
Description: Evaluate its serum level and detect its relation to the activity and severity of Alopecia Areata.
Study: NCT06588907

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacaine Hydrochloride
Description: After preparing the infraclavicular block site, a 22-gauge needle, guided by ultrasound, will be placed in the 6-7 o'clock position in the same plane as the ultrasound probe. Subsequently, lateral, medial, and posterior cords described as hypoechoic nerve fascicles within hyperechoic structures will be identified. Initially, 2 mL of saline will be administered to confirm proper spread. Once confirmed, 20 mL of 0.25% bupivacaine (prepared by diluting 10 mL of 0.5% bupivacaine with 10 mL of normal saline) will be injected in fractional doses with intermittent negative aspiration. Fifteen minutes after this procedure, anesthesia depth will be assessed using a cold-hot test, followed by reduction and application of the cast.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ketamine
Description: Until the recovery period, patients will be closely monitored by an experienced doctor or nurse during sedation. Emergency equipment will be readily available in case of any complications. The following protocol will be used for procedural sedation-analgesia (PSA): Ketamine will be administered intravenously at a dose of 0.5-1 mg/kg. Patients with Numeric Rating Scale (NRS) scores above 5 may receive additional doses of 0.25-1 mg/kg, repeated every 5 to 10 minutes as needed.
Study: NCT06661421

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dry Needling
Description: This intervention combines Dry Needling Therapy (DNT) with routine physical therapy for children with spastic cerebral palsy. The experimental group will receive DNT alongside physical therapy, while the control group will undergo only physical therapy. Routine Physical Therapy includes a warm-up, stretching, and strengthening exercises like hamstring stretches and squats, adjusted over a month with increasing intensity. Dry Needling targets the gastrocnemius muscle using a fast-in, fast-out technique with sterile needles, applied weekly for 10 weeks. This combined approach aims to reduce spasticity, improve mobility, and enhance range of motion, distinguishing it from standard therapies.

Intervention type: OTHER
Group type: OTHER
Intervention: Cerebral Palsy conventional Treatment
Description: Sessions will include a 5-minute warm-up, stretching, and strengthening exercises. Hamstring stretches will be done with the child supine, one leg flat, and the opposite hip flexed to 90°. Active knee extension will be held for 5 seconds, followed by a 40-second assisted stretch, repeated five times. If a short psoas is detected, a prone psoas stretch will involve assisted hip extension for 5 seconds, followed by a 40-second hold, repeated five times. Strengthening exercises like squats, heel rises, and step-ups with a loaded backpack will target the lower extremities. The program will last one month, with three sessions per week, focusing on hamstring stretches and progressive resistance exercises.
Study: NCT06670261

Intervention type: OTHER
Intervention: Data collection
Description: Retrospective pseudo-anonymized clinical and scannographic data from the routine management of patients in rhino-sinusology consultations.

Intervention type: OTHER
Intervention: Data collection
Description: Retrospective pseudo-anonymized clinical and scannographic data from the routine management of patients in rhino-sinusology consultations.
Study: NCT06673290

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Sirolimus (RAPAMUNE)
Description: Use of different doses of the same drug

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sirolimus (RAPAMUNE)
Description: Use of different doses of the same drug
Study: NCT06672068

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TY-9591 80mg QD+pemetrexed+Cisplatin/Carboplatin
Description: TY-9591 80mg QD+pemetrexed 500mg/m²（D1，Q3w）+Carboplatin AUC5/ Cisplatin 75mg/m²（D1，Q3w\*4 cycles）

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TY-9591 160mg QD+pemetrexed+Cisplatin/Carboplatin
Description: TY-9591 160mg QD+pemetrexed 500mg/m²（D1，Q3w）+Carboplatin AUC5/ Cisplatin 75mg/m²（D1，Q3w\*4 cycles）
Study: NCT05751317

Intervention type: DIAGNOSTIC_TEST
Intervention: Culture
Description: * Samples will be transported to Medical Microbiology and Immunology Laboratory and will be inoculated on MacConkey medium.~* Pink colonies will be inoculated on bile esculin agar medium.~* Enterococci produce blackening of the agar

Intervention type: DIAGNOSTIC_TEST
Intervention: Culture
Description: * Samples will be transported to Medical Microbiology and Immunology Laboratory and will be inoculated on MacConkey medium.~* Pink colonies will be inoculated on bile esculin agar medium.~* Enterococci produce blackening of the agar

Intervention type: DIAGNOSTIC_TEST
Intervention: Staining:
Description: The growing colonies on bile esculin agar medium will be examined microscopically after staining by Gram stain.

Intervention type: DIAGNOSTIC_TEST
Intervention: Staining:
Description: The growing colonies on bile esculin agar medium will be examined microscopically after staining by Gram stain.

Intervention type: DIAGNOSTIC_TEST
Intervention: Biochemical reactions:
Description: * Catalase test.~* Salt tolerance test

Intervention type: DIAGNOSTIC_TEST
Intervention: Biochemical reactions:
Description: * Catalase test.~* Salt tolerance test

Intervention type: DIAGNOSTIC_TEST
Intervention: VITEK
Description: Automated identification of Enterococci will be done with VITEK2 system.

Intervention type: DIAGNOSTIC_TEST
Intervention: VITEK
Description: Automated identification of Enterococci will be done with VITEK2 system.
Study: NCT06672471

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: No Post Operative Antibiotics for intervention group
Description: No Post Operative Antibiotics in patients going clean contaminated head and neck surgery

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Post Operative Antibiotics for one day
Description: Control group will receive perioperative as well as post operative antibiotics for one day
Study: NCT05751317

Intervention type: DIAGNOSTIC_TEST
Intervention: Antibiotic sensitivity test
Description: Strains confirmed as Enterococci will be examined for their antibiotic susceptibility by modified Kirby Bauer's disc diffusion method on Mueller-Hinton Agar.

Intervention type: DIAGNOSTIC_TEST
Intervention: nanoparticles effect
Description: The effect of nanoparticles on Enterococci antimicrobial resistance pattern

Intervention type: DIAGNOSTIC_TEST
Intervention: The biofilm formation activity
Description: The biofilm formation activity of Enterococci isolates will be tested using the microtiter plate technique

Intervention type: DIAGNOSTIC_TEST
Intervention: molecular diagnosis
Description: Molecular identification of some virulence factors genes and antibiotic resistance genes of Enterococci using PCR
Study: NCT06670846

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Lollipop
Description: Distraction using a Lollipop 15 minutes before anesthesia

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: distraction using intranasal Midazolam
Description: Distraction using intranasal Midazolam 15 minutes before anesthesia
Study: NCT05257603

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: RPCW
Description: Psychosocial intervention that includes two in-person group sessions two weeks apart and two on-line units during the intervening two weeks. Behavioral training, educational materials, discussions and videos, as well as interactive online materials are included to increase awareness of sexual assault cues, dating and drinking protective behavioral strategies, barriers to defending oneself, and saying no to hazardous drinking and sexual advances.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: HEC
Description: Health Education time and attention control that includes two in-person sessions two weeks apart and two on-line units during the intervening two weeks. The in-person sessions cover stress management and sleep, while the online units cover nutrition and physical activity. The in-person and online sessions are designed to foster discussion and be interactive.