TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06605222

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-7787 injection
Description: Firstly Dose Escalation and Dose Expansion of SHR-7787 injection monotherapy should be conducted.
Study: NCT06665828

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: REGN9533
Description: Administered per the protocol

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo
Description: Administered per the protocol.
Study: NCT06666751

Intervention type: PROCEDURE
Intervention: Cataract plus Microstent surgery
Description: Both the Hydrus microstent and iStent Inject W are used in combination with cataract surgery, in order to help lower intraocular pressure for patients with open-angle glaucoma. The microstent is a small flexible device that is inserted into the eye during cataract surgery in order to improve the outflow of fluid from the eye.

Intervention type: PROCEDURE
Intervention: Cataract plus Microstent surgery
Description: Both the Hydrus microstent and iStent Inject W are used in combination with cataract surgery, in order to help lower intraocular pressure for patients with open-angle glaucoma. The microstent is a small flexible device that is inserted into the eye during cataract surgery in order to improve the outflow of fluid from the eye.
Study: NCT06668610

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: StarStim 32, Neuroelectrics, Spain - Real multifocal tDCS
Description: Real multifocal tDCS will be delivered with an intensity of 2.0 mA over 8 electrodes positioned over the frontal and temporal areas in the left hemisphere according to the international 10/10 EEG system. The overall duration of stimulation will be set at 20 minutes.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: StarStim 32, Neuroelectrics, Spain - Real multifocal tDCS
Description: Real multifocal tDCS will be delivered with an intensity of 2.0 mA over 8 electrodes positioned over the frontal and temporal areas in the left hemisphere according to the international 10/10 EEG system. The overall duration of stimulation will be set at 20 minutes.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: StarStim 32, Neuroelectrics, Spain - Sham multifocal tDCS
Description: Sham multifocal tDCS will be delivered with an intensity of 2.0 mA over 8 electrodes positioned over the frontal and temporal areas in the left hemisphere according to the international 10/10 EEG system. The overall duration of stimulation will be set at 30 seconds.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: StarStim 32, Neuroelectrics, Spain - Sham multifocal tDCS
Description: Sham multifocal tDCS will be delivered with an intensity of 2.0 mA over 8 electrodes positioned over the frontal and temporal areas in the left hemisphere according to the international 10/10 EEG system. The overall duration of stimulation will be set at 30 seconds.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive treatment
Description: During the two cycles, all participants will undergo traditional cognitive stimulation therapy, involving paper-and-pencil exercise and computerised activity on several cognitive domains including memory, attention, and executive functions (duration 30-40 minutes) .

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive treatment
Description: During the two cycles, all participants will undergo traditional cognitive stimulation therapy, involving paper-and-pencil exercise and computerised activity on several cognitive domains including memory, attention, and executive functions (duration 30-40 minutes) .
Study: NCT05351827

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mild Intermittent Hypoxia
Description: Participants will breathe 8% oxygen through a non-diffusable bag that is connected to a 5-way stopcock. The inspiration side of the system is then connected to a 2-way non-rebreathing valve which is connected to a pneumotachometer that is connected to a tight fitting facemask. 100% oxygen and carbon dioxide are titrated into the system to ensure the appropriate hypoxic and hypercapnic stimulus is delivered. The investigators will lower oxygen to 55-60 mmHg and maintain end-tidal carbon dioxide 1-3 mmHg above individual baseline values. The protocol starts with 10 minutes of baseline breathing (room air) then followed by 10 more minutes of breathing room air with the additional carbon dioxide. Thereafter, individuals undergo 12 2-minute bouts of hypoxia with 2 minutes of normoxia (room air) interspersed between episodes. The intervention protocol concludes with 20 minutes of monitoring all breathing and cardiovascular measurements.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham
Description: Participants will breathe 21% oxygen through a non-diffusable bag that is connected to a 5-way stopcock. The inspiration side of the system is then connected to a 2-way non-rebreathing valve which is connected to a pneumotachometer that is connected to a tight fitting facemask. No supplemental oxygen or carbon dioxide will be used during the sham protocol. The protocol starts with 10 minutes of baseline breathing (room air) then followed by 10 more minutes of breathing room air with the additional carbon dioxide. Thereafter, individuals undergo 12 2-minute bouts of hypoxia with 2 minutes of normoxia (room air) interspersed between episodes. The intervention protocol concludes with 20 minutes of monitoring all breathing and cardiovascular measurements.
Study: NCT06616051

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mHealth referral reminder to identified visually impaired school children
Description: Intervention consists of a Multi-component health message which was framed with assistance from a panel of public health consultant and research supervisors. WHO health promotion and prevention messages library from has also been utilized. Two parts make up the computerized text message reminder system: an SMS application for text messaging that is sent automatically and a web-based application for child registration and automated reminder scheduling. The parents will get text messages written in Urdu, the native language, as part of the intervention. Mothers will receive instruction on how to access and interpret SMS text messages upon enrollment. The message consists of four parts and will be sent as an SMS: Health promotion message, visual depiction of a child vision, a customized action plan with details on how to get to the hospital including the location and a snapshot of the key location, how much money is needed.
Study: NCT06606444

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Surfactant Administration Through Laryngeal or Supraglottic Airways
Description: While the child is spontaneously breathing on nasal CPAP treatment, the neonatal intensive care (NICU) physician will place the LMA and assess for adequate airway by CO2-detection, chest movement, pulmonary auscultation of bilateral breath sounds, gastric insufflation, oxygen saturation and heart rate. A placement attempt should not last more than 30 seconds. Surfactant will be administered slowly in 1-2 ml aliquots (Curosurf 200 mg/kg) via an appropriate size laryngeal mask airway. The neonate should primarily be spontaneously breathing and if needed receives gentle supportive positive pressure ventilation (PPV). Gentle supportive PPV is given for 30 seconds after surfactant is administered, before LMA is removed.
Study: NCT06617182

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thalidomide
Description: Patients in thalidomide group took thalidomide orally at a dose of 100mg once a day for 8 weeks.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Glutamine
Description: In the glutamine group, two capsules of glutamine were taken orally 3 times a day for 8 weeks.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thalidomide+Glutamine
Description: Patients in thalidomide combined with glutamine group took thalidomide orally at a dose of 100mg once a day and two capsules of glutamine were taken orally 3 times a day for 8 weeks.
Study: NCT06620705

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Left bundle branch area pacing
Description: Pacing of the left bundle branch area using a transvenous pacemaker lead

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Biventricular pacing
Description: Pacing of the right and left ventricle using transvenous pacemaker leads
Study: NCT06618235

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: THEO-260
Description: Oncolytic Virus
Study: NCT06621212

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: mitoxantrone hydrochloride liposome
Description: Mitoxantrone hydrochloride liposome (30 mg/m\^2) on day 1, every 4 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cytarabine
Description: Cytarabine (100 mg/m\^2 ) on day 1-7, every 4 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Venetoclax 100 mg on day 2，200 mg on day 3，400 mg on day 4-10, every 4 weeks
Study: NCT06619158

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Crown modification
Description: Zirconia glaze removal and polish after crown removal to reduce roughness and prohibit plaque adhesion
Study: NCT06620770

Intervention type: OTHER
Intervention: questionnaires
Description: Morisky and SF12 Questionnaires delivery at inclusion, 6, 12 and 18 months

Intervention type: OTHER
Intervention: questionnaires
Description: Morisky and SF12 Questionnaires delivery at inclusion, 6, 12 and 18 months
Study: NCT06620354

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selumetinib
Description: Patients without indications for surgical excision were evaluated with 6 cycles of daily oral smetinib capsules (20-50mg bid) for 30 days, individually calculated based on patient body surface area (BSA)
Study: NCT06620796

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arm 1
Description: Ivonescimab combined with Cadonilimab plus EC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: second-line group
Description: AK112+AK104+paclitaxel
Study: NCT06621706

Intervention type: DEVICE
Intervention: Gastric ultrasonography
Description: Women will be requested to fast 2 hours for clear drinks, 6 hours for a light meal, and 8 hours for a meal high in fried or fatty content prior to their next antenatal clinic visit.~On the day of assessment, fasting and dietary compliance will be confirmed individually with each woman and Gastric ultrasonography will be performed after sex and eight hours of fasting food.~Women will be first scanned in a semi-recumbent (45 degrees head up) supine position, followed by a semi-recumbent (45 degrees head up) right lateral position (RLP). In both positions the gastric antrum will be identified in the sagittal plane with its internal anatomical landmarks identified, i.e. the left lobe of the liver anteriorly and the abdominal aorta posteriorly.

Intervention type: DEVICE
Intervention: Gastric ultrasonography
Description: Women will be requested to fast 2 hours for clear drinks, 6 hours for a light meal, and 8 hours for a meal high in fried or fatty content prior to their next antenatal clinic visit.~On the day of assessment, fasting and dietary compliance will be confirmed individually with each woman and Gastric ultrasonography will be performed after sex and eight hours of fasting food.~Women will be first scanned in a semi-recumbent (45 degrees head up) supine position, followed by a semi-recumbent (45 degrees head up) right lateral position (RLP). In both positions the gastric antrum will be identified in the sagittal plane with its internal anatomical landmarks identified, i.e. the left lobe of the liver anteriorly and the abdominal aorta posteriorly.
Study: NCT06618482

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Kinesiotaping
Description: Low back kinesiotaping

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Kinesiotaping
Description: Transversus abdominis kinesiotaping
Study: NCT06623097

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Supervised Exercise and Diet Program
Description: A home-based, virtually supervised, moderate-to-vigorous aerobic and resistance exercise intervention with a certified cancer exercise trainer. The exercise sessions will include aerobic exercise on a stationary bicycle and total-body resistance training using resistance bands. Stationary bicycle, resistance bands, activity tracking watch, and Wi-Fi enabled tablet (if needed) will be provided to participants. Dyads will receive remotely delivered nutrition coaching sessions (via telephone or video conferencing) with a health coach each week. Mediterranean eating pattern goals will be tracked using the journal feature of the My Wellness Research platform website.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Unsupervised Exercise and Diet Program
Description: A home-based, unsupervised moderate-to-vigorous aerobic and resistance exercise intervention. The exercise sessions will include aerobic exercise on a stationary bicycle and total-body resistance training using resistance bands. Stationary bicycle, resistance bands, activity tracking watch will be provided to participants. Dyads will receive Mediterranean eating pattern goals, with an introductory session conducted by research staff. Diet intake will be tracked using the journal feature My Wellness Research platform website.
Study: NCT06424990

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: balance training with TENS
Description: children will receive Biodex balance training with TENS for 30 minutes a day, 5 days per week for 4 weeks

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Balance training with placebo TENS
Description: children will receive Biodex balance training with placebo TENS for the same period.
Study: NCT06620965

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mulligan Mobilization Technique
Description: NAGs (Natural Apophyseal Glides) involve passive oscillatory movements of a spinal facet joint in an anterocranial direction, performed with the patient seated. SNAGs (Sustained Natural Apophyseal Glides) maintain facet glides during active movements, aiming to reach the joint\&#39;s end range. In SNAGs, the patient actively participates, and overpressure is applied at the end of movements to enhance the range of motion. Techniques include increasing rotation, lateral flexion, flexion, and extension. These were applied by a certified physiotherapist three times a week for four weeks, aiming to improve joint mobility without causing pain.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Proprioceptive Neuromuscular Facilitation (PNF) Technique
Description: Proprioceptive Neuromuscular Facilitation (PNF) Technique: PNF consists of four movement patterns in two diagonals:~Flexion-left rotation and extension-right rotation Flexion-right rotation and extension-left rotation 3 PNF techniques were applied.~Combined Isotonic Contractions: This technique involves concentric, eccentric, and stabilizing contractions of a muscle group (agonist). The goal is to increase active range of motion (ROM), strength, and improve control and coordination.~Dynamic Stabilization (Stabilizing Reversal): This involves applying resistance in various directions to prevent movement, aiming to enhance dynamic stability, strength, and agonist-antagonist coordination.~Hold-Relax Technique: This relaxation method involves isometric contractions against maximum resistance without movement to increase passive ROM and reduce pain. These were applied by physiotherapist three times a week for four weeks, aiming to improve joint mobility without causing pain.
Study: NCT06624215

Intervention type: PROCEDURE
Intervention: Appendectomy
Description: Robotic-assisted or laparoscopic appendectomy for acute appendicitis.

Intervention type: PROCEDURE
Intervention: Appendectomy
Description: Robotic-assisted or laparoscopic appendectomy for acute appendicitis.
Study: NCT06619613

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Alzheimer Disease (AD)
Description: CM383 injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Alzheimer Disease (AD)
Description: CM383 injection
Study: NCT05150587

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Rifaximin
Description: Rifaximin tablets

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Rifaximin
Description: Rifaximin tablets

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablets
Study: NCT05919147

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pioglitazone 45 mg
Description: The dose of pioglitazone will not exceed 45 mg once daily. Pioglitazone dose will titrate progressively over the first three weeks.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will have the same appearance as the active drug.
Study: NCT05351138

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TENS
Description: In the study, CE certified tens device with Biolito brand, which is used specifically for incontinence treatment, will be used. The electrodes used during the intervention will be placed to the parasacral region (S2-S4). While the current is given, the power of the device will be gradually increased in 1 mA intervals. The lower value of the stimulation will be 10 mA and the upper value will be 25 mA, and the treatment will be continued with any value that the child can tolerate in this range.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Massage
Description: The massage will be applied to the abdominal area between the subcostal lower border and the anterior superior of the spina iliaca. Massage techniques are as follows: Abdominal patting, colon patting, colon kneading, colon patting again, abdominal patting again. It will be advanced with deep abdominal strokes, then the starting point will be returned with transverse superficial strokes for the transversus abdominis muscle and oblique superficial strokes for the rectus abdominis muscle, and these strokes will be repeated 3 times each, a total of 6 times. Afterwards, 3 times column brushing, 3 times column kneading and 3 times column plastering will be done, respectively. At the end, a total of 6 abdominal strokes will be performed for both the transversus abdominis and oblique abdominal muscles as in the beginning.
Study: NCT06434597

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SPH5030
Description: SPH5030：Oral, QD, 600mg
Study: NCT05880953

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Parent-to-parent coaching
Description: Parents and parent coaches will meet as needed via the family's preferred method. Engagement may include text messaging, phone conferencing, Zoom conferencing, or occasional in-home or hospital visiting as preferred. Coaching sessions will vary based on family desired frequency and location, but may include: on-site in the family home or hospital room, telephone or video conferencing, or asynchronous contacts via email or text messaging. The template for the intervention includes an initial introductory session which is intended to build rapport and orient the parent to our program. Subsequent session topics may include: addressing specific needs including topics of interviewing and selecting home health agencies, expectation setting for home based nursing care, recruiting for home health team from inpatient settings, and recruiting for home health team from professional and personal networks.
Study: NCT05247827

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Targeted phantom limb motor execution (exercise)
Description: The targeted phantom motor execution is a specific training program for people with TTA that has been designed to improve the muscles' strength, coordination, and flexibility at the amputated and contralateral intact sides. Such training consists of repeated short-term, short rest interval, and moderate-intensity exercises (Schoenfeld 2010, Krutki, Mrowczynski et al. 2017). Targeted phantom motor execution can improve the body image considering its induced muscular impacts. People with TTA will be trained to follow specific movements of their foot-ankle complexes simultaneously, in order to increase PLA, as well as induce muscular morphologic and brain neuroplastic changes (Moseley and Brugger 2009).
Study: NCT05539521

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Remimazolam Besylate
Description: sedation drugs

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol
Description: Propofol
Study: NCT05100719

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: alverine-citrate + simethicone and lactase
Description: Patients who randomized in the first arm are treated with alverine-citrate + simethicone and lactase.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: alverin-citrate + simethicone with placebo
Description: Patients in the second arm receive alverin-citrate + simethicone with placebo without lactase.
Study: NCT06316219

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nomegestrol Acetate/Estradiol 2.5mg/1.5mg
Description: hysteroscopic polipectomy after starting 14-day treatment with oral Nomegestrol Acetate/Estradiol 2.5mg/1.5mg at any time of the menstrual cycle
Study: NCT05374759

Intervention type: DIAGNOSTIC_TEST
Intervention: neutrophil gelatinase-associated lipocalin
Description: When the patient is diagnosed with sepsis and on the 3rd day of the follow-up, blood samples will be taken and NGAL levels will measured.

Intervention type: DIAGNOSTIC_TEST
Intervention: neutrophil gelatinase-associated lipocalin
Description: When the patient is diagnosed with sepsis and on the 3rd day of the follow-up, blood samples will be taken and NGAL levels will measured.

Intervention type: DIAGNOSTIC_TEST
Intervention: renal resistive index
Description: When the patient is diagnosed with sepsis and on the 3rd day of the follow-up, renal resistive index will measure and record.

Intervention type: DIAGNOSTIC_TEST
Intervention: renal resistive index
Description: When the patient is diagnosed with sepsis and on the 3rd day of the follow-up, renal resistive index will measure and record.
Study: NCT06619613

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Matched placebo

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Matched placebo

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Matched placebo

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Matched placebo
Study: NCT06682871

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Analgesia
Description: Postoperatively, patients will be given analgesia

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Analgesia
Description: Postoperatively, patients will be given analgesia
Study: NCT04797325

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vedolizumab
Description: Repeatedly vedolizumab infusion at week 0, 2, 6, 14, 22

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Prednisolone
Description: tablet prednisolone plus infliximab in severe cases.
Study: NCT04699227

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cuff application with inflation
Description: The blood pressure cuff will be placed on the arm and inflated.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham inflation
Description: The blood pressure cuff will be placed on the arm and not inflated.