TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05562973

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: Participants will receive three psilocybin sessions, at least two weeks apart.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: Participants will receive three psilocybin sessions, at least two weeks apart.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: Participants will receive three psilocybin sessions, at least two weeks apart.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: Participants will receive three psilocybin sessions, at least two weeks apart.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: Participants will receive three psilocybin sessions, at least two weeks apart.
Study: NCT06092099

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TENA SmartCare Change Indicator
Description: The TENA SmartCare Change Indicator is an accessory to absorbent incontinence products, intended for use on individual(s) with urinary incontinence who are dependent on one or more caregivers to change the absorbent incontinence product. The TENA SmartCare Change Indicator estimates the degree of urine saturation in the absorbent incontinence product and notifies the caregivers. This facilitates the caregiver's decision regarding when to change the absorbent incontinence product. As the current study is needed to validate the updated device, the full system will not be used, only the sensor part.
Study: NCT05459922

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wearable bright light therapy device
Description: Light treatment glasses (Re-timer®) will be used to deliver bright light therapy. This device is available commercially and allows participants to freely move around while receiving light from LEDs positioned below the eyes. Re-timer® can be worn over glasses and does not interfere with vision, reading, or computer work.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Wearable placebo light therapy device
Description: The placebo Re-timer® emits light intensity to a level that will not impact sleep and circadian timing and appears identical to the original Re-timer®.
Study: NCT05787314

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Low Glycemic Index Diet
Description: 1. Participants who came to the hospital for control and were interested in the study contacted the study researchers and eligibility was determined through face-to-face interviews. Potential participants were invited to a screening visit to verify eligibility.~2. The LGID program was initiated as an outpatient treatment in patients who applied to a dietitian. 3) Medium and high GI carbohydrates (GI \> 55) were excluded from the diet and only low GI (GI \< 50) foodstuffs were allowed. 4) A list of low glycemic index foods were given to the patients. In addition, a list of foods to avoid (medium and high glycemic index) is provided.
Study: NCT06244069

Intervention type: DIAGNOSTIC_TEST
Intervention: Temporal arterial biopsy
Description: Collection of 30 ml of peripheral blood in ethylenediaminetetraacetic acid (EDTA) tubes performed at baseline, 6 months, 12 months and in case of flare before month 12. In addition, the temporal artery specimen (at least 5 mm in length) exceeding that used for clinical activity (at least 10 mm in length in accordance with current clinical recommendations) will be digested to use for research purposes (about protocols for collecting, processing, storing and sending biopsy, refer to Standard Operating Procedures, SOP).

Intervention type: DIAGNOSTIC_TEST
Intervention: Whole exome sequencing
Description: Patients with CHIP will be identified and characterized by using whole exome sequencing from the peripheral blood samples. M-CHIP will be further characterized by:~i) clone dimension as defined by Variant Allele Fraction (VAF); ii) mutations in specific genes such as DNMT3A, Tet methylcytosine dioxygenase 2 (TET2), Additional Sex combs (ASXL1), or Janus kinase 2 (JAK2); iii) multiple mutations.~L-CHIP will be further characterized by:~i) clone dimension as defined by the VAF; ii) mutations in specific genes such as Dual Specificity Phosphatase 22 (DUSP22), FAT atypical cadherin 1 (FAT1), (Histone-lysine N-methyltransferase 2D (KMT2D); iii) multiple mutations; iv) co-occurrence of mutations heralding M- and L-CHIP.
Study: NCT06234995

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Levodopa
Description: Participants will take levodopa in dosages prescribed by their care provider. Patients will be instructed to not take their regularly prescribed PD medications for 12 hours prior to the study assessment, as is typical for clinical evaluations in patients with PD. Participants will be tested in both levodopa-off (after 12 hours of not having medication) and levodopa-on states.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Clinical DBS Setting
Description: Deep brain stimulation performed with the patients' optimized clinical setting.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sham DBS
Description: Deep brain stimulation performed with sham stimulation.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: DBS Setting Maximizing Prefrontal Activation
Description: Deep brain stimulation performed to maximize the activation of the prefrontal cortico-STN projections.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: DBS Setting Minimizing Prefrontal Activation
Description: Deep brain stimulation performed to minimize the activation of the prefrontal cortico-STN projections.
Study: NCT03127111

Intervention type: GENETIC
Intervention: Gene methylation analysis
Description: Genomic DNA extracted from paired fresh-frozen tumor and normal tissues is used for specific gene methylation or CIMP status analysis by MethyLight or bisulfite sequencing. Whole-genome bisulfite sequencing will be used to identify novel candidate set of predictive markers.

Intervention type: GENETIC
Intervention: Gene expression analysis
Description: RNA extracted from paired fresh-frozen tumor and normal tissues or serum is used for specific gene expression analysis by real-time reverse-transcription PCR (RT-qPCR). RNA-seq will be used to identify novel candidate set of predictive markers.

Intervention type: GENETIC
Intervention: SNP analysis
Description: Genomic DNA extracted from serum is used for specific SNP analysis by using sequencing. GWAS with SNPs array will be used to identify novel candidate set of predictive markers.

Intervention type: GENETIC
Intervention: Protein expression analysis
Description: Tissue microarray made from formalin-fixed paraffin-embedded (FFPE) paired tumor and normal tissues is used for specific protein expression analysis by immunohistochemistry staining.
Study: NCT06412679

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Life Skills Education
Description: The RESETTLE-IDPs study compares two innovative delivery approaches for a culturally-adapted life skills education (LSE) intervention aimed at improving the mental health and well-being of internally displaced persons in Nigeria. The interventions are distinguished by their mode of delivery (in-person vs. WhatsApp-based), their focus on peer support and skill-building, and their tailoring to the specific needs and challenges of IDP populations.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Life Skills Education
Description: The RESETTLE-IDPs study compares two innovative delivery approaches for a culturally-adapted life skills education (LSE) intervention aimed at improving the mental health and well-being of internally displaced persons in Nigeria. The interventions are distinguished by their mode of delivery (in-person vs. WhatsApp-based), their focus on peer support and skill-building, and their tailoring to the specific needs and challenges of IDP populations.
Study: NCT06244069

Intervention type: DIAGNOSTIC_TEST
Intervention: Single cell transcriptomics
Description: The investigators will identify actively inflamed arterial biopsies from three treatment-naïve patients without CHIP, and three treatment-naïve patients with CHIP driven by the most relevant gene mutation. Arterial wall Cluster of Differentiation (CD) 45+ leukocytes will be isolated after digestion of arterial tissue and characterized by single cell transcriptomics, with a specific focus on wall infiltrating T cells and macrophages and their subsets (eg: Vascular dendritic cells, Th1, Th2, Th17, Treg, M1- and M2-like,...). Frequencies of these subsets and their genetic expression will be compared between wall-infiltrating leukocytes from GCA patients with or without CH, focusing on histological events supposed to be pathogenic in GCA, or known to be dysfunctional in CHIP.
Study: NCT06089226

Intervention type: OTHER
Intervention: Assessment Group
Description: In our prospectively planned study, patients who meet the inclusion criteria will be evaluated by the researcher via face-to-face interview method and the evaluations specified in the outcome measurements. Patients participating in the study will first be given a general explanation about the purpose of the study and evaluation methods, and their written consent will be obtained.
Study: NCT05542875

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Thrust Manipulation
Description: Prone thoracic extension manipulation technique will be applied from T2 - T6 to participants of Group A (Experimental group). Intervention will be applied on alternate days with a total of 4 treatment sessions
Study: NCT05207371

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Biological
Description: Intravenous injection of GAIA-102 alone or with Pembrolizumab (KEYTRUDA®︎)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Biological
Description: Intravenous injection of GAIA-102 alone or with Pembrolizumab (KEYTRUDA®︎)
Study: NCT06550414

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexmedetomidine
Description: Active comparator: dexmedetomidine group

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Bupivacain
Description: Placebo comparator: bupivacaine group
Study: NCT05748951

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Canalicular occlusion device
Description: Occlusive device is inserted into the tear duct to block tear drainage
Study: NCT04717700

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selinexor 20 MG Oral Tablet
Description: Comparing an alternating regimen of selinexor-lenalidomide/bortezomib-dexamethasone to standard bortezomib-lenalidomide-dexamethasone

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bortezomib Injection
Description: Comparing an alternating regimen of selinexor-lenalidomide/bortezomib-dexamethasone to standard bortezomib-lenalidomide-dexamethasone
Study: NCT06435442

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Epaminurad, Naproxen
Description: Period 1: Epaminurad/ Period 2: Naproxen -\> Epaminurad+Naproxen
Study: NCT05542875

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Non-Thrust manipulation
Description: Maitland grade III or IV thoracic 0manipulation will be given to participants of Control group from T1 to T6. Posterior to anterior glide over spinous process will be maintained for 30 seconds. Intervention will be applied on alternate days with a total of 4 treatment sessions
Study: NCT06435442

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Epaminurad
Description: Epaminurad
Study: NCT04876612

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Transforaminal epidural steroid injection (TFESI)
Description: Well trained pain physician performs all the fluoroscopy-guided transforaminal epidural steroid injection (TFESI), who is not involved in evaluating study variables. Electrocardiography, noninvasive blood pressure, heart rate, and peripheral oxygen saturation were monitored for all patients before, while, and after conducting procedure. For TFESI, patients are prone positioned, and skin preparation on injection site is done with chlorohexidine. Procedure is conducted under fluoroscopy guidance at the patient's symptom complaining level. After confirming with a contrast medium, 3 ml of 0.1875% ropivacaine and 5 mg of dexamethasone are administered.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Transforaminal epidural steroid injection (TFESI)
Description: Well trained pain physician performs all the fluoroscopy-guided transforaminal epidural steroid injection (TFESI), who is not involved in evaluating study variables. Electrocardiography, noninvasive blood pressure, heart rate, and peripheral oxygen saturation were monitored for all patients before, while, and after conducting procedure. For TFESI, patients are prone positioned, and skin preparation on injection site is done with chlorohexidine. Procedure is conducted under fluoroscopy guidance at the patient's symptom complaining level. After confirming with a contrast medium, 3 ml of 0.1875% ropivacaine and 5 mg of dexamethasone are administered.
Study: NCT05542875

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard Treatment
Description: Standard treatment protocol includes moist heat, TENS and Post isometric relaxation technique. Standard treatment will be given to both groups on every session. Standard treatment consists of:~Superficial Moist Heat (Device): Superficial moist heat will me applied for 10 minutes on Upper Trapezius TENS (Device): TENS will be applied for 10 minutes at 80-100Hz, the electrodes will be placed at upper trapezius.~Post-isometric Relaxation (procedure/surgery): 5-10 repetions of Post Isometric relaxation technique will be applied on various muscle groups which include Upper trapezius, levator scapulae, sternocleidomastoid and scalenes.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard Treatment
Description: Standard treatment protocol includes moist heat, TENS and Post isometric relaxation technique. Standard treatment will be given to both groups on every session. Standard treatment consists of:~Superficial Moist Heat (Device): Superficial moist heat will me applied for 10 minutes on Upper Trapezius TENS (Device): TENS will be applied for 10 minutes at 80-100Hz, the electrodes will be placed at upper trapezius.~Post-isometric Relaxation (procedure/surgery): 5-10 repetions of Post Isometric relaxation technique will be applied on various muscle groups which include Upper trapezius, levator scapulae, sternocleidomastoid and scalenes.
Study: NCT05481177

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Ivabradine
Description: Ivabradine is a drug approved to treat tachycardia in volunteers with heart failure. This study is to determine benefit of ivabradine treatment in postural orthostatic tachycardia syndrome (POTS) in participants with Long haul Covid.
Study: NCT06435442

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Epaminurad placebo
Description: Epaminurad placebo
Study: NCT05094661

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: BiPAP
Description: The patient recives respiratory support with bilevel positive airway pressure system until treatment improves or fails (needs intubation/dies).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: CPAP
Description: The patient recives respiratory support with continuous positive airway pressure system until treatment improves or fails (needs intubation/dies).
Study: NCT02465138

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ketorolac
Description: Intravenous ketorolac

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Intravenous saline
Study: NCT04871672

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pilates Exercises
Description: basic five pilates intermediate workout based on the principles of Pilates

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Home Exercise program
Description: home exercise
Study: NCT04717700

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide capsule
Description: Comparing an alternating regimen of selinexor-lenalidomide/bortezomib-dexamethasone to standard bortezomib-lenalidomide-dexamethasone

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone Oral
Description: Comparing an alternating regimen of selinexor-lenalidomide/bortezomib-dexamethasone to standard bortezomib-lenalidomide-dexamethasone
Study: NCT06182085

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PRI-002
Description: Oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PRI-002
Description: Oral administration

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Oral administration
Study: NCT06334380

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Virtual Reality Modules Only
Description: Participants will complete self-paced VR modules prior to and after surgery (prehab/rehab) and will be provided with technical assistance from the study team.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Reality Modules + Live Physical Therapist Support
Description: Participants will complete self-paced VR modules prior to and after surgery (prehab/rehab) and will be provided with technical assistance from the study team. Participants will also have access to up to three live PT sessions via Zoom where they can ask questions and complete modules with PT feedback.
Study: NCT04686110

Intervention type: OTHER
Group type: OTHER
Intervention: angiographic optical coherence tomography
Description: angiographic optical coherence tomography

Intervention type: OTHER
Group type: OTHER
Intervention: angiographic optical coherence tomography
Description: angiographic optical coherence tomography
Study: NCT06351800

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Predictplusprevent intervention
Description: The intervention is based on validated risk algorithms to predict depression and anxiety and includes: 1) Mobile applications as main user's interface; 2) a DSS that helps participants to develop their own personalized plans to prevent (PPP) depression and/or anxiety; 3) eight intervention modules (the core of the system) including activities to prevent depression and anxiety, to be proposed and monitoring by the DSS. The intervention is biopsychosocial and multi-component, including the following modules: physical exercise, improving sleep, expanding relationships, problem solving, improving communication skills, assertiveness training, making decisions and managing thoughts. Participants will implement the recommendations and the tool will monitor these actions, offering feedback to improve their PPP at 3, 6, 9 and 12 months.
Study: NCT04623281

Intervention type: DEVICE
Intervention: Sixty device
Description: Prototype wearable hydration monitor to be worn by patient during dialysis and at night
Study: NCT05190328

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Muscle Energy Technique
Description: Experimental: Muscle Energy Technique Post isometric relaxation: Patient will perform isometrics on upper trapezius and levator scapulae one by one. Each isometric contraction will be held for 10 seconds and then participants will be asked to relax the contraction with exhalation. This will be repeated five times in one session.~Routine Physical Therapy including TENS, Hot Pack, Strengthening, and stretching exercises will also be delivered along with Muscle energy technique.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Active Release Technique
Description: Experimental: Active Release Technique: Therapist will apply deep pressure on both sides of levator scapulae and upper trapezius muscles (over the area of tenderness) and the patient is instructed to actively move the muscle from the shortened to a lengthened position and thereby breaking adhesions. 1 set of 5 repetitions in one session.~Routine Physical Therapy including TENS, Hot Pack, Strengthening, and stretching exercises will also be delivered along with Active Release Technique.
Study: NCT06308289

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Global Posture Re-education
Description: Focusing on postural correction and movement patterns

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Active Cycle of Breathing Technique
Description: Emphasizing breathing control, thoracic expansion, and mucus clearance techniques

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Active Cycle of Breathing Technique
Description: Emphasizing breathing control, thoracic expansion, and mucus clearance techniques
Study: NCT05302999

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gabapentin
Description: Generic gabapentin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gabapentin
Description: Generic gabapentin

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Inert cellulose
Study: NCT06403605

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Mirragen Wound Matrix
Description: Offloading- patient will be offloaded in a diabetic CAM boot after treatment, or total contact cast if patient cannot be fit in a diabetic boot. Other names; pressure relief.~Additional outer dressing application-application of outer moisture retentive dressing, and a multilayer compression dressing. Other names; outer protective dressing.~Mirragen Wound Matrix-application of Mirragen to wound site along with standard of care treatment.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Fibracol
Description: Offloading- patient will be offloaded in a diabetic CAM boot after treatment, or total contact cast if patient cannot be fit in a diabetic boot. Other names; pressure relief.~Additional outer dressing application-application of outer moisture retentive dressing, and a multilayer compression dressing. Other names; outer protective dressing.~Mirragen Wound Matrix-application of Mirragen to wound site along with standard of care treatment.
Study: NCT06625177

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TEV-53408
Description: TEV-53408 injection administered subcutaneously
Study: NCT05805332

Intervention type: OTHER
Intervention: pulmonary rehabilitation
Description: The participants would undergo pulmonary rehabilitation.
Study: NCT04539808

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Capecitabine
Description: Given PO

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluorouracil
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Irinotecan Hydrochloride
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Leucovorin Calcium
Description: Given IV
Study: NCT06351800

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Psychoeducational intervention
Description: To know the level of risk of experiencing depression and/or anxiety in the next 12 months. In addition, participants assigned to this intervention will have free access to the 24 self-help pamphlets for preventing depression and anxiety.