TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05662228

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lorazepam
Description: Lorazepam will be administered as an oral pill over the first 15 days of study in a daily titration, starting at 0.5 mg BID and increasing to up to 2 mg three times daily, as tolerated. Dosing will continue at the maximum tolerated dose through the 12-week endpoint. Participants will be titrated off lorazepam over at least four weeks after completing the endpoint visit. Taper will be tailored to individuals for safety reasons with a goal of decreasing dosage by 25% weekly. Phone check ins will be conducted every three days to monitor patient.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intravenous immunoglobulin (IVIG)
Description: IVIG will be administered as a series of four intravenous infusions at a dose of 1 mg/kg with pre-infusion medications of 1 mg/kg diphenhydramine and 15 mg/kg acetaminophen. The first two infusions occur at baseline and one day after (induction dosing), followed by one infusion at 4 weeks and one infusion at 8 weeks.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tofacitinib
Description: Tofacitinib will be administered as an oral pill at 5 mg twice daily over the 12-week study.
Study: NCT04489602

Intervention type: OTHER
Intervention: ObsQoR-10F Questionnaire
Description: The ObsQoR-10F questionnaire consists of 10 items assessing different aspects of postpartum recovery: physical comfort and pain, physical independence and emotional status. It takes two minutes to complete all the items. If the patient is not able to read the questionnaire herself, a third person can ask the questions orally to the patient. If the patient has returned home with her child, she can be contacted by phone to complete the questionnaire. Each item is scored from 0 to 10 and the total score is the sum of the score for each item, which is a score from 0 to 110.
Study: NCT04993430

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS8807
Description: HRS8807 monotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS8807
Description: HRS8807 monotherapy

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: HRS8807、SHR6390
Description: HRS8807 in combination with SHR6390

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS8807、SHR6390
Description: HRS8807 in combination with SHR6390
Study: NCT06659809

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tele-care video-feedback intervention (TVFI)
Description: The TVFI 6 weekly sessions are organized in two subsequent phases: 4 sharing the focus sessions and 2 integration sessions. Sharing the focus sessions are dedicated to the discussion between the psychologist and the mother of specific themes related to parenting and parent-infant interaction: physical stimulation, responsiveness, teaching, and parenting experience. The goal of the sharing the focus sessions is to develop insights about the infants' behavioral signals, the best ways to provide stimulations and get in touch, strategies to promote emotion regulation, and to sustain cognitive and behavioral achievements. In the subsequent two integration sessions, the mother plays with the infant while the psychologist provides guidance based on topics previously discussed during the first four sessions. The goal is to promote a pragmatical translation of the insights developed during the sharing the focus sessions into the interactive exchanges between the mother and the infant.
Study: NCT06659003

Intervention type: OTHER
Intervention: Pilot Implementation of Network Canvas into HBH Partner Services
Description: Our team deployed our network data capture software - Network Canvas - into Partner Services at HBH to examine feasibility and acceptability and to provide initial evidence of efficacy (examining impacts on data quality, number of partners notified, and timeliness). Further, our team worked closely with HBH on developing implementation strategies, a Network Canvas interview protocol, evaluation measures, and training materials for their staff. Finally, we provided the HBH team technical support, and regular coaching, supervision, and evaluation.
Study: NCT06659302

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: I-inTERACT North Step 1
Description: Initial questionnaires completed followed by initial meeting with therapist for baseline evaluation.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: I-inTERACT North step 2
Description: Two online modules completed by family plus two online zoom coaching sessions with therapist.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: I-inTERACT North
Description: Full program will consist of an additional 5 sessions with online modules and virtual coaching sessions with therapist.
Study: NCT06658639

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ultrasound lipolysis
Description: Ultrasound lipolysis uses a Luvitra device to emit low-frequency ultrasound pulsed waves. The abdominal area is divided into two sections and the patient is placed in a comfortable supine lying position. The cavitation head is applied slowly to each segment in small circular movements. The treatment lasts 30 minutes on each side, with each session lasting 60 minutes. The same abdominal area is treated every two weeks for three months. The procedure involves cleaning the skin with alcohol cotton.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Cryolipolysis
Description: The study utilized Lipocool, a cryolipolysis apparatus from Korea, with a thermoelectric cooling element. Participants were treated with thermal coupling gel on their abdomen, and the tissue was drawn into the applicator with a moderate vacuum. The device was used for 40-50 minutes, with energy extraction controlled by sensors. The system stopped cold exposure and the clinician released the vacuum. Participants underwent cryolipolysis sessions every 2 weeks for 3 months.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Low Caloric Diet
Description: A low-calorie diet is a structured plan that restricts daily caloric intake, often used for weight loss. It involves consuming 1,200 to 1,500 calories daily, creating a calorie deficit. However, it requires discipline and safety. The diet is low in fat (20-25%), high in complex carbohydrates (60%), and sufficient in protein (25-50%).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Low Caloric Diet
Description: A low-calorie diet is a structured plan that restricts daily caloric intake, often used for weight loss. It involves consuming 1,200 to 1,500 calories daily, creating a calorie deficit. However, it requires discipline and safety. The diet is low in fat (20-25%), high in complex carbohydrates (60%), and sufficient in protein (25-50%).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low Caloric Diet
Description: A low-calorie diet is a structured plan that restricts daily caloric intake, often used for weight loss. It involves consuming 1,200 to 1,500 calories daily, creating a calorie deficit. However, it requires discipline and safety. The diet is low in fat (20-25%), high in complex carbohydrates (60%), and sufficient in protein (25-50%).
Study: NCT06658561

Intervention type: PROCEDURE
Group type: OTHER
Intervention: cold snare polypectomy
Description: Place the special cold snare in the normal mucosa 1-2mm away from the polyp edge. Tighten the snare at a constant speed and gently lift it up and then excision.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: hot snare polypectomy
Description: According to evaluation of the polyps, directly place the snare on the edge of the polyp including a clear margin of normal tissue (1-2 mm) or after submucosal injection. Tighten the snare at a constant speed and gently lift it up.Use the electrocoagulation and electroscission mode, power on for several seconds until the polyp is cut off.
Study: NCT06586138

Intervention type: OTHER
Intervention: STAI (State-Trait Anxiety Inventory) Scale : Psychological inventory of 20 self-report items on a 4-point scale
Description: Patient completed STAI Scale in the 24 hours before Maintenance of Wakefulness Test during the hospitalization
Study: NCT06342492

Intervention type: OTHER
Intervention: Coronary Sinus Lead Revision
Description: Coronary Sinus Lead Revision

Intervention type: OTHER
Intervention: Coronary Sinus Lead Revision
Description: Coronary Sinus Lead Revision
Study: NCT06604858

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Pembrolizumab 200 mg administered every three weeks intravenously on day 1 of each cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Carboplatin: area under the curve (AUC) 1.5, intravenously on day 1, day 8 and day 15 of each 21-days cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: Paclitaxel: 80 mg/m2, intravenously on day 1, day 8 and day 15 of each 21-days cycle.
Study: NCT06662305

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Kick-Nic! mobile phone application
Description: The Kick-Nic! app has seven modules that cover core CBT strategies using skills, graphic illustrations, and interactive components to help adolescents quit using e-cigarettes.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: NCI Quit Vaping website
Description: The NCI webpage provides quitting tobacco resources for youth, including for e-cigarettes. The information provided is similar to the CBT skills modeled by the Kick-Nic! app.
Study: NCT05355259

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: GECKO Active Guidewire
Description: The GECKO device is intended to introduce devices used for treatment, at a desired anatomical location (cervical carotid artery, for example) in the central circulatory system. The GECKO guidewire itself is not meant to perform a treatment but is used to set the primary access that will allow performance of the treatments.
Study: NCT05416372

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Religious Engagement in Health Intervention
Description: Religious Engagement in Health Intervention for blood pressure (BP) includes three evidence-based components: (1) educational sessions for Christian and Muslim leaders on religious teachings and medical aspects of BP, (2) equipping religious leaders to provide BP teaching in their communities using knowledge learned from educational sessions and through longitudinal mentorship meetings, and (3) community BP screening organized by religious leaders in partnership with local health care workers, and referrals for clinical care as needed.
Study: NCT06025695

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: GSK's liquid oral live attenuated HRV
Description: 2 doses of GSK's liquid oral live attenuated HRV study intervention administered orally at Day 1 and Month 1, according to the immunization schedule for HRV study intervention licensed outside of China.
Study: NCT05238844

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ATI-2173 25mg
Description: ATI-2173 is a liver-targeted phosphoramidate prodrug of clevudine designed to enhance anti-HBV activity while decreasing systemic exposure to clevudine. It will be dosed as a capsule by mouth.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vebicorvir 300mg
Description: Vebicorvir (formerly ABI-H0731) is an orally administered, potent and selective small molecule inhibitor of the HBV core protein

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Viread 300Mg Tablet
Description: Viread is a nucleotide analogue reverse transcriptase inhibitor used for chronic hepatitis B virus.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Viread 300Mg Tablet
Description: Viread is a nucleotide analogue reverse transcriptase inhibitor used for chronic hepatitis B virus.
Study: NCT05973240

Intervention type: OTHER
Intervention: Participation in an web-based survey
Description: Patients who agree to participate will access a web-based survey (SurveyMonkey) via social media, mobile messages, or emails. The invitation will provide study details, eligibility criteria, and tasks. Patients will confirm inclusion/exclusion criteria upon access, and those ineligible will opt out. Data collection will take approximately 10 minutes per patient. Collected data will be sent to an electronic data collector and saved as an eCRF file in REDCap. The study will conduct two cross-sectional data collection rounds using web surveys to ensure anonymity. Convenience sampling will target anticoagulated patient associations' webpages and social media (e.g., Feder-AIPA, AICCA). In the second round, participants will be informed not to resubmit if they have already completed the survey to avoid overlapping responses.

Intervention type: OTHER
Intervention: Participation in an web-based survey
Description: Patients who agree to participate will access a web-based survey (SurveyMonkey) via social media, mobile messages, or emails. The invitation will provide study details, eligibility criteria, and tasks. Patients will confirm inclusion/exclusion criteria upon access, and those ineligible will opt out. Data collection will take approximately 10 minutes per patient. Collected data will be sent to an electronic data collector and saved as an eCRF file in REDCap. The study will conduct two cross-sectional data collection rounds using web surveys to ensure anonymity. Convenience sampling will target anticoagulated patient associations' webpages and social media (e.g., Feder-AIPA, AICCA). In the second round, participants will be informed not to resubmit if they have already completed the survey to avoid overlapping responses.
Study: NCT05547594

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Multimodal surgical prehabilitation
Description: Participants will be encouraged to engage in regular physical activity (endurance and resistance exercise), eat healthily and undergo cognitive behavioural therapy (the latter only if required) during the weeks prior to surgery.
Study: NCT04835389

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AlloGen Liquid
Description: Amniotic fluid

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% normal saline
Study: NCT05736653

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Task-specific PCMS
Description: 120 pairs of TMS and PNS volleys will be administered during electromyography-triggered functional electrical stimulation (FES)-assisted task-specific training (task-specific PCMS). In the task-specific PCMS, participants will first grasp a spherical ball when prompted by an auditory 'Ready' cue, and upon seeing a visual 'Go' cue will voluntarily extend the wrist and fingers to release the ball. After the 'Go cue', our customized stimulation delivery algorithm triggers the TMS and PNS only when the extensor digitorum communis (EDC) muscle activity exceeds a pre-determined threshold. The algorithm will then trigger FES to EDC after detecting EDC activity (\~2 ms after PNS) for the next 2 seconds, allowing the pairing of PCMS (TMS and PNS) with the voluntary movement of EDC without the confounding effects of FES.
Study: NCT05086991

Intervention type: OTHER
Intervention: Follow up
Description: like group descriptions
Study: NCT05616052

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Semaglutide
Description: treatment with different dosage regimes

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Semaglutide
Description: treatment with different dosage regimes
Study: NCT01353066

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Intensive Medical Treatment

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: IMM+Roux-en-Y Gastric Bypass (RYGBP)
Study: NCT05773833

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Go Healthy program
Description: Weekly food boxes of fresh fruits and vegetables for 16 weeks; healthy eating and traditional foods curriculum available inside the box; monthly in-person healthy eating and traditional Indigenous foods cooking workshop; Indigenous cooking demonstration video website links to accompany recipes; and a kitchen starter kit with kitchen cooking supplies
Study: NCT05569356

Intervention type: BIOLOGICAL
Intervention: Prospective
Description: -Additional blood samples -Myocarditis biopsy sample (routine care) -Additional pericardial fluid sample (routine care)

Intervention type: OTHER
Intervention: Retrospective
Description: None (only data collection)
Study: NCT05705687

Intervention type: DRUG
Group type: OTHER
Intervention: BEP Protocol
Description: anticancer therapy

Intervention type: DRUG
Group type: OTHER
Intervention: Dose-dense regimen
Description: T-BEP-Oxaliplatin followed by Cisplatin - Ifosfamide - Paclitaxel

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Early tumor resection or HD-CT
Description: TIP protocol + early surgery or high-dose chemotherapy if surgery not feasible or metastatic disease
Study: NCT05010434

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sintilimab and Bevacizumab Combined with Radiotherapy
Description: Before radiotherapy: Bevacizumab+Sintilizumab, Q3w, 2 cycles in total. Radiation therapy: 30-50Gy/10 fractions. After radiotherapy: Bevacizumab+Sintilizumab, Q3w until disease progression or toxicity is intolerable.
Study: NCT05131035

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: SCORES (Specific COgnitive Remediation with Support)
Description: This study evaluates the effectiveness of a 10-week cognitive remediation program plus group coaching and therapy to improve processing speed and, in turn, social functioning and attenuated positive symptoms in CHR subjects. The SCORES (Specific COgnitive Remediation with Support) intervention is a novel CR program combined with group coaching, performance-based rewards, game-like tasks, and therapy elements to increase engagement and retention.~In the 2 year, R61 phase, all participants will complete 40 hours of CR (4 hrs per week) with a mid-point assessment (20 hours of CR at 5 weeks) to determine the impact of CR on processing speed as measured by the MCCB.~The second phase of the study (R33) will compare the 40 hours of speeded brain training to 40 hours of non-speeded brain training. This three year study will allow for a replication and assessment of specificity of the targeted intervention.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SCORES (Specific COgnitive Remediation with Support)
Description: This study evaluates the effectiveness of a 10-week cognitive remediation program plus group coaching and therapy to improve processing speed and, in turn, social functioning and attenuated positive symptoms in CHR subjects. The SCORES (Specific COgnitive Remediation with Support) intervention is a novel CR program combined with group coaching, performance-based rewards, game-like tasks, and therapy elements to increase engagement and retention.~In the 2 year, R61 phase, all participants will complete 40 hours of CR (4 hrs per week) with a mid-point assessment (20 hours of CR at 5 weeks) to determine the impact of CR on processing speed as measured by the MCCB.~The second phase of the study (R33) will compare the 40 hours of speeded brain training to 40 hours of non-speeded brain training. This three year study will allow for a replication and assessment of specificity of the targeted intervention.
Study: NCT05754372

Intervention type: DIAGNOSTIC_TEST
Intervention: user-friendly and widely applicable algorithm to tailor the treatment of acute neonatal hyperammonemia
Description: user-friendly and widely applicable algorithm to tailor the treatment of acute neonatal hyperammonemia, based on kinetic modelling
Study: NCT05740644

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CM-1600
Description: Healthy subjects undergoing a manual blood loss of up to 500mL followed by an infusion of 1 liter of normal saline will be connected to the CM-1600 device.
Study: NCT04930172

Intervention type: DEVICE
Intervention: Steerable introducers
Description: endografts via total transfemoral approach for visceral vessels cannulation
Study: NCT04653727

Intervention type: OTHER
Intervention: Cross-sectional survey
Description: No intervention.
Study: NCT06025695

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: PCV-free liquid formulation of GSK's oral live attenuated HRV
Description: 2 doses of PCV-free liquid formulation of GSK's oral live attenuated HRV study intervention administered orally at Day 1 and Month 1, according to the immunization schedule for HRV study intervention licensed outside of China. PCV-free implies no detection of PCV-1 and PCV-2 according to the limit of detection of the tests used.
Study: NCT05645393

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: topical estrogen product
Description: estrogen topical gel or cream

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: topical estrogen product
Description: estrogen topical gel or cream
Study: NCT04858035

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Perceptual training
Description: Perceptual training involves self-paced presentation of auditory stimuli via a computerized software program.~Stimuli are organized into three separate tasks:~Tasks 1 and 3 will train category goodness judgment: Participants will hear 75 naturally produced speech tokens containing /r/ from various speakers, with a balance of correct and incorrect productions. They will classify each /r/ as correct or incorrect and receive feedback on the accuracy of their classification. Tasks 1 and 3 differ in that task 1 will feature a subset of items designed to provide focused practice on a specific context (e.g., initial /r/ as in red; /r/ as syllable nucleus as in sir), with increasing difficulty over time, whereas task 3 will feature randomly selected items representing all contexts and difficulty levels.~Task 2: Participants will hear 75 items drawn from the synthetic rake-wake continuum used in the identification task administered at baseline.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Production training
Description: Instruction: Discuss tongue shapes for /r/. Pre-practice: relatively unstructured, highly interactive elicitation; provide models and placement cue and KP on every trial.~Structured syllable practice: Practice will occur in blocks of 10 consecutive trials on the same syllable (e.g., 10 /ra/), after which a new syllable will be addressed (e.g., 10 /re/--but note that in the fully blocked condition, the same syllable should occur in two consecutive blocks of 10).
Study: NCT05139329

Intervention type: DIAGNOSTIC_TEST
Intervention: Imaging
Description: To better understand the prevalance of further imaging for evaluation of myocarditis, all patients with negative workup will be included and see what number of patients undergo further CMRI, FGD-PET, or speckle tracking echocardiography. Patients will then be categorized as those with myocarditis with positive diagnosis, negative diagnosis or unknown.