TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05327062

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment
Description: The following information and data will be obtained from the routine clinical work up of the patients: Patient demographics, cardiovascular medical history, and clinical examination; 12-lead ECG; Standard echocardiography; Computed tomography angiography for visualization of atria, ventricle, and coronary sinus.~Imaging data will be transferred to the cloud-based web-platform using a dedicated software provided by study sponsor. Data processing includes evaluating the quality of the data and calculation of various anatomical and electrical parameters, and identification of the target zone as a point in the target vein closest to the latest activation zone.~LV-lead location is based on the information provided by the dedicated software followed by visual X-ray based verification of anatomically suitable/most desirable position.~The patient will undergo CRT device implantation according to local protocols.
Study: NCT04576442

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Asthma-PASS
Description: The investigator will collaborate with the student's primary care provider (PCP) by sending a letter via facsimile, and/or email to ensure appropriate medications are prescribed or adjusted and rescue medications are available at school. Community Health Workers (CHWs) will follow up with PCPs as needed to provide reminders about prescriptions for controlled medications and to ensure a MAF is provided to schools to allow rescue medication administration by nurses. CHWs will work with local pharmacies when possible to have prescribed medications delivered to schools and homes. For students without a PCP, we will refer families to one of Montefiore Medical Center's 20 practices throughout the Bronx. For students without medical insurance or who are unable to go to a Montefiore clinic, the NYC DOE physicians who routinely attend NYC schools will provide medical care and prescribe appropriate medications.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Basic Asthma Management (AM)
Description: PCPs and caregivers will be notified that children in the AM group have persistent/uncontrolled asthma that warrants use of guideline-based preventative medications.
Study: NCT06427343

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: High-dose ferric derisomaltose
Description: After baseline assessment, participants will be randomized in a 1:1 ratio to receive a high-dose IV iron regimen and a low-dose IV iron regimen. After the initial iron repletion, ferritin concentration and TSAT were measured every three months and the results used to determine the dose of ferric derisomaltose during follow-up.~In the high-dose group, participants will receive repeat iron dosing as long as the serum ferritin was not \>700 ng/mL, or if TSAT was not \>40% during follow-up.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Low-dose ferric derisomaltose
Description: In the low-dose group, participants will receive repeat iron dosing if ferritin \<100 ng/mL or if ferritin 100-300 ng/mL and TSAT \>20% during follow-up.
Study: NCT05212129

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Percutaneous vagal nerve stimulation (pVNS) device
Description: Subjects in Treatment Arm B will enter a six-week, prospective open label treatment trial with the FDA-approved and commercially available device IB-Stim. This is an ambulatory, neurostimulation device which consists of a battery powered, externally affixed generator with 4 wire leads attached to electrode/needle arrays affixed to the outer ear. The device delivers low voltage (3.2V) stimulation in alternating frequencies for a total of 5 days (around the clock).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Acoustic vagal nerve stimulation (aVNS) treatment
Description: All subjects receiving acoustic therapy via active VNS (aVNS; n=30) or sham VNS (sVNS; n=30) will enter a four-week, randomized, double-blind clinical trial during which they will listen to either computer altered/filtered vocal music (active treatment) that has been designed to stimulate vagal calming vs. regular non-filtered music (sham treatment). The stimuli will mirror the acoustic intervention known as the Safe and Sound Protocol. This protocol has been found to reduce auditory hypersensitivities and calming the autonomic nervous system by increasing vagal regulation of the heart via brainstem ventral vagal complex. The acoustic intervention may be played by an electronic device (i.e. smartphone, tablet, laptop, mp3) and delivered virtually with the help of trained coaches.
Study: NCT06363188

Intervention type: DEVICE
Intervention: Radial Extracorporeal shockwave
Description: a device used by physiotherapist to treat various musculoskeletal problems and it was here firstly used to accelerate the bone healing process after bone fracture
Study: NCT05409560

Intervention type: OTHER
Intervention: Swimming participants in the 6-hour cold water swim
Description: The 6-hour cold water swim was the qualifying swim for the English Channel swim during the Channel Swim Camp Dinard 2021 and participants were the swimmers registered for the 6-hour cold water swim who volunteered to participate in this study
Study: NCT05926076

Intervention type: OTHER
Intervention: Treatment plan
Description: Patients with different diagnoses will get different treatment options

Intervention type: OTHER
Intervention: Treatment plan
Description: Patients with different diagnoses will get different treatment options
Study: NCT04576442

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Child/Caregiver Education session
Description: The investigator will provide in-school child asthma education sessions delivered by trained, bilingual (English-Spanish) Community Health Workers (CHWs) using an established manualized protocol from past and current studies designed to improve knowledge and self-efficacy. Each child will receive two 1-on 1, 20-minute developmentally appropriate educational sessions at school 3-4 weeks apart. Sessions will cover: 1) asthma basics, symptoms and triggers; and 2) medications and correct administration technique. Caregivers will be called after each child session to highlight key points reviewed with the child and answer questions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Child/Caregiver Education session
Description: The investigator will provide in-school child asthma education sessions delivered by trained, bilingual (English-Spanish) Community Health Workers (CHWs) using an established manualized protocol from past and current studies designed to improve knowledge and self-efficacy. Each child will receive two 1-on 1, 20-minute developmentally appropriate educational sessions at school 3-4 weeks apart. Sessions will cover: 1) asthma basics, symptoms and triggers; and 2) medications and correct administration technique. Caregivers will be called after each child session to highlight key points reviewed with the child and answer questions.
Study: NCT05005884

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oral intake of medication
Description: Prescription of oral phenolics 250 mg two times daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Prescription of oral phenolics 250 mg two times daily
Study: NCT04740411

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Common Elements Toolbox (COMET)
Description: COMET is an online unguided self-help intervention that lasts approximately 60-80 minutes.
Study: NCT03240900

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Electrical Stimulation
Description: Electrical stimulation - a needle attached to an cathode polarity will be placed within the intercostal space near the 4th intercostal nerve. A second needle attached to the anode polarity will be inserted into the serratus anterior muscle. Both electrodes will then be attached to a Grass SD9 stimulator and the voltage and frequency of the stimulation will be titrated to the point where contraction of the intercostal muscles is palpable. It will be maintained at this level for one hour at which point the wires will be removed. This technique is part of the standard of care for peripheral nerve surgeries of the extremities and is proven to be safe in humans.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: This breast will receive no electrical stimulation; the mastectomy and reconstruction will proceed with no intervention.
Study: NCT04444570

Intervention type: DEVICE
Intervention: Continuous glycemia measuring device (Dexcom) implantation into the subcutaneous tissue
Description: 14 days before the date of the surgery and after the surgery patient will have implemented the device for continuous glycemia measurement (Dexcom). During standard control visit 14 days after the surgery for skin sutures removal the device will be taken out and data of whole period of time will be collected

Intervention type: DEVICE
Intervention: Continuous glycemia measuring device (Dexcom) implantation into the subcutaneous tissue
Description: 14 days before the date of the surgery and after the surgery patient will have implemented the device for continuous glycemia measurement (Dexcom). During standard control visit 14 days after the surgery for skin sutures removal the device will be taken out and data of whole period of time will be collected
Study: NCT04879602

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: suction with bronchoscopy
Description: suction with bronchoscopy
Study: NCT05162807

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Psychoeducational Video on Palliative Care
Description: The intervention is a psychoeducational video introducing palliative care and discussing its purpose, structure, benefits, and efficacy.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Educational Video on Nutrition
Description: The attention control is a video on nutrition and healthy eating during cancer survivorship.
Study: NCT05238051

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gastric residual volume measurement stopped.
Description: GRV is checked during routine enteral nutrition, but we think that GRV prolongs the time to reach target calories and does not reduce complications.
Study: NCT05323851

Intervention type: BEHAVIORAL
Intervention: COVID-surg-SPIGC questionnaire
Description: The questionnaire aimed to evaluate how the COVID-19 pandemic determined a shift in daily practice through a multidimensional assessment of surgical clinical care in three different time frames.
Study: NCT06305039

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Diagnostic tests of cochlear implant or acoustic hearing function
Description: Because the cochlear implant participants in the study will use cochlear implant devices that they have already received as part of their standard-of-care treatment, the medical device itself is not an intervention for the purposes of this study. The intervention here will be to carry out diagnostic tests of cochlear implant or acoustic hearing function. This will include perceptual tests of sound localization, speech understanding in noise, binaural fusion, and loudness comparisons.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Diagnostic tests of cochlear implant or acoustic hearing function
Description: Because the cochlear implant participants in the study will use cochlear implant devices that they have already received as part of their standard-of-care treatment, the medical device itself is not an intervention for the purposes of this study. The intervention here will be to carry out diagnostic tests of cochlear implant or acoustic hearing function. This will include perceptual tests of sound localization, speech understanding in noise, binaural fusion, and loudness comparisons.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Diagnostic tests of cochlear implant or acoustic hearing function
Description: Because the cochlear implant participants in the study will use cochlear implant devices that they have already received as part of their standard-of-care treatment, the medical device itself is not an intervention for the purposes of this study. The intervention here will be to carry out diagnostic tests of cochlear implant or acoustic hearing function. This will include perceptual tests of sound localization, speech understanding in noise, binaural fusion, and loudness comparisons.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Targeted aural rehabilitation of the poorer performing ear
Description: Subjects will undergo listening practice on a tablet computer over headphones at home. For the test group, the aural rehabilitation will be targeted at the poorer ear. For the comparison control group, a sham aural rehabilitation will present speech to both ears.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Targeted aural rehabilitation of the poorer performing ear
Description: Subjects will undergo listening practice on a tablet computer over headphones at home. For the test group, the aural rehabilitation will be targeted at the poorer ear. For the comparison control group, a sham aural rehabilitation will present speech to both ears.
Study: NCT06442358

Intervention type: DEVICE
Group type: OTHER
Intervention: Pulsenmore ES home ultrasound device
Description: Pulsenmore ES device is a portable home used ultrasound device which allow the patient to perform an ultrasound scan from the comfort of their home under the supervision of a healthcare provider
Study: NCT05982951

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Shoulder PENG block
Description: Ultrasound guided insertion of a needle between subscapularis tendon and deltoid with injection of 10 mi 0.25% bupivacaine after confirming right plane of injection

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Shoulder PENG block
Description: Ultrasound guided insertion of a needle between subscapularis tendon and deltoid with injection of 10 mi 0.25% bupivacaine after confirming right plane of injection
Study: NCT05420753

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Transjugular Intrahepatic Portosystemic Shunt (TIPS) creation
Description: During a TIPS procedure, the interventional radiologist, with the help of x-ray and ultrasound guidance, makes a channel through the liver to connect the portal vein (the vein that carries blood from the digestive organs to the liver) to one of the hepatic vein (three veins that carry blood away from the liver back to the heart) using a special type of needle. The interventional radiologist then replaces the needle with a wire and catheter, and a small tubular device called a stent graft is placed in this channel to keep the pathway open between the two blood vessels.
Study: NCT05283837

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pertuzumab (ZRC-3277)
Description: Pertuzumab in combination with Trastuzumab and Docetaxel will be administered via intravenous (IV) infusion every 3 weeks for 06 cycles.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Pertuzumab (Perjeta®)
Description: Pertuzumab in combination with Trastuzumab and Docetaxel will be administered via intravenous (IV) infusion every 3 weeks for 06 cycles.
Study: NCT05770310

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JS015
Description: Patient receives specific dose of JS015. The administration method of JS015 is intravenous infusion.
Study: NCT05309850

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lifestyle tool
Description: Regular use of the digital Lifestyle tool
Study: NCT05940675

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Food and Nutrition
Description: A key element is that children receive a free of charge healthy do-it-yourself school lunch 4 days per week. The meals adhere to the Nordic Nutrition Recommendations and the Danish Food-Based Dietary Guidelines with focus on fish, wholegrains, fruits and vegetables and drinking water as well as stimulation of children's food literacy. Other intervention components involve the after school clubs, local retail stores and the parents.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Physical Activity (FitFirst)
Description: To ensure that all children reach the recommended 3x30 minutes of vigorous activity per week, we will implement three weekly 40-minute sessions in the school curriculum. These sessions will be carried out throughout the study period and will encompass modified and varied sporting activities and games, which promote motivation, physical literacy, active involvement of all children, and high training intensity.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Sleep and screen media
Description: The aim of this component is to promote healthy sleep and screen media behaviours. Sleep and screen media recommendations will be presented for parents at three parent workshops and in electronic infographics. Teachers/pedagogues will facilitate small assignments on screen media and sleep practices with children during school time. Children will talk about and reflect upon screen media and sleep practices in their family, based on assignments and material from e.g., Medierådet (The Danish Media Council). The results of the children's assignments will be presented to their parents at later workshops. This is done to integrate the children's perspective in the parent workshops, especially in relation to screen media habits.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Community capacity building
Description: Community capacity building in selected local communities. To promote healthier eating, children and families need to be supported within their local community by food environments that make the healthy choice the easy choice and not a challenge in their everyday life. To promote physical activity, the children will be invited to participate in activities in the local sports clubs including camps in the holidays.
Study: NCT05636280

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: schroth exercise
Description: In this study, Schroth exercise training applied 3 days a week for 6 weeks in people with Adolescent Idiopathic Scoliosis will be applied by a physiotherapist trained in schroth.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: traditional scoliosis exercise
Description: In this study, traditional scoliosis exercise training applied 3 days a week for 6 weeks in people with Adolescent Idiopathic Scoliosis will be applied by a physiotherapist.
Study: NCT05409105

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Mangoes
Description: Frozen mangoes, 2 cups per day, 2 weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Water
Description: 2 cups/day bottled water, 2 weeks
Study: NCT04848493

Intervention type: BIOLOGICAL
Intervention: COVID-19 vaccines
Description: This is an observational prospective study whose general objective is to assess the impact of COVID-19 vaccination in terms of induction of humoral and cell-mediated immune responses in selected fragile (altered immunocompetence) populations.

Intervention type: BIOLOGICAL
Intervention: COVID-19 vaccines
Description: This is an observational prospective study whose general objective is to assess the impact of COVID-19 vaccination in terms of induction of humoral and cell-mediated immune responses in selected fragile (altered immunocompetence) populations.

Intervention type: BIOLOGICAL
Intervention: COVID-19 vaccines
Description: This is an observational prospective study whose general objective is to assess the impact of COVID-19 vaccination in terms of induction of humoral and cell-mediated immune responses in selected fragile (altered immunocompetence) populations.

Intervention type: BIOLOGICAL
Intervention: COVID-19 vaccines
Description: This is an observational prospective study whose general objective is to assess the impact of COVID-19 vaccination in terms of induction of humoral and cell-mediated immune responses in selected fragile (altered immunocompetence) populations.
Study: NCT06158243

Intervention type: OTHER
Intervention: Sono-anatomical Study
Description: The arm is abducted (90°), externally rotated, with the forearm flexed over the arm (90°). A linear ultrasound probe (8-15 MHz) is placed in front of the humeral head, in a sagittal plane. Location begins at axillary level, vessels, nerves and humerus are identified, and the probe is moved medially to reach and identify the humeral head.

Intervention type: OTHER
Intervention: Sono-anatomical Study
Description: The arm is abducted (90°), externally rotated, with the forearm flexed over the arm (90°). A linear ultrasound probe (8-15 MHz) is placed in front of the humeral head, in a sagittal plane. Location begins at axillary level, vessels, nerves and humerus are identified, and the probe is moved medially to reach and identify the humeral head.
Study: NCT00013078

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Physical restoration intervention
Study: NCT06249529

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Airway Bypass
Description: Bypass stent(s) are implanted to allow air trapped in the parenchyma to escape
Study: NCT04903977

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Laboratory tests: blood and faeces tests
Description: To be performed at V2

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Gynaecological and proctological examinations
Description: To be performed at V1 (Examination with a gynaecological speculum, Bimanual examination, Rectal examination, and Anoscopy)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: 3-D Endoanal Ultrasound
Description: To be performed at V1 (as a reference and for group assignment)

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ONIRY measurement
Description: To be performed at V2 (the electrical impedance of anal sphincter muscles will be measured)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: High-resolution anorectal manometry
Description: To be performed at V3

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: ECG
Description: To be performed at V1 and V2 (for safety reasons)
Study: NCT05532696

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ABT-101
Description: Patients will receive ABT-101 by oral administration on a 28-day cycle
Study: NCT04814238

Intervention type: PROCEDURE
Intervention: Aortic Root Surgery
Description: First time, isolated, minimally invasive (mini-sternotomy, RALT) aortic root or aorta surgery

Intervention type: PROCEDURE
Intervention: Aortic Root Surgery
Description: First time, isolated, minimally invasive (mini-sternotomy, RALT) aortic root or aorta surgery

Intervention type: PROCEDURE
Intervention: Aortic Root Surgery
Description: First time, isolated, minimally invasive (mini-sternotomy, RALT) aortic root or aorta surgery
Study: NCT06505811

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Guaranteed Income ($500/monthly)
Description: Participants receive $500 monthly for up to 18 months.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Active Comparison ($20/monthly)
Description: Participants receive $20 monthly for up to 18 months.
Study: NCT05384977

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [14C]-NV-5138
Description: Single dose, given as oral solution, 1600 mg