TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05466318

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide
Description: 30 mg oral twice weekly for 2 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cladribine
Description: 6 mg/m2 intravenously once daily @ Day -7 \~ -3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemcitabine
Description: 2500 mg/m2 intravenously @ Day -7, -3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Busulfan
Description: 3.2 mg/kg intravenously once daily @ Day -7 \~ -4

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carmustine
Description: 300 mg/m2 intravenously @ Day -8

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Etoposide
Description: 200 mg/m2 intravenously once daily @ Day -7 \~ -4

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cytarabine
Description: 400 mg/m2 intravenously once daily @ Day -7 \~ -4

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Melphalan
Description: 140 mg/m2 intravenously @ Day -3

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Autologous hematopoietic stem cell transplant
Description: autologous hematopoietic stem cells infusion after ChiCGB or BEAM chemotherapy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Autologous hematopoietic stem cell transplant
Description: autologous hematopoietic stem cells infusion after ChiCGB or BEAM chemotherapy
Study: NCT05003817

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Percutaneous left ventricular unloading
Description: Percutaneous left ventricular unloading involves the placement of a mechanical pump which draws blood from the left ventricle and returns it into the aorta at flow rates approaching native cardiac output.
Study: NCT06524050

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: standard care
Description: standard care
Study: NCT04905901

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tranexamic acid
Description: Tranexamic acid nebulization 15 minutes before sinus surgery

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tranexamic acid
Description: Tranexamic acid nebulization 15 minutes before sinus surgery
Study: NCT05493605

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Delivery of a long-term Holter 21 days Or placement of an implantable holter from the outset so syncope
Description: The intervention consists of setting up a morphological and rhythmological cardiological follow-up of patients with confirmed Wilson's disease. It will require the wearing of a long-term Holter (21 days) and for some patients the installation of an implantable cardiac monitor.
Study: NCT06352034

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Empathy Training
Description: The intervention contains five themes: 1) An overview of empathy and emotions. 2) Cognitive empathy and clarification technique. 3) Emotional empathy and reflection of feelings technique. 4) Awaring and dealing with the inner feelings while empathizing. 5) Empathy timing and emotional pendulum technique.
Study: NCT05401669

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Trans-radial access
Description: Cerebral angiography performed by trans-radial access

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Trans-femoral access
Description: Cerebral angiography performed by trans-femoral access
Study: NCT06446037

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Non-invasive EMG band instrumentation
Description: The sensed EMG signals from the subjects will be decoded by Phantom X algorithm and used to drive various gestures in a desk-mounted hand prosthesis
Study: NCT06636292

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Virtual Reality Distraction and Disassociation (VRDD) Stage 1
Description: Participants wear a VR headset which plays VR content/material pre- endoscopy only.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Virtual Reality Distraction and Disassociation (VRDD) Stage 1&2
Description: Participants wear a VR headset which plays VR content/material pre- endoscopy and during endoscopy.
Study: NCT04586023

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fenebrutinib
Description: Participants will receive fenebrutinib.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Teriflunomide
Description: Participants will receive teriflunomide.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will receive teriflunomide-matching placebo or fenebrutinib-matching placebo.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: Participants will receive teriflunomide-matching placebo or fenebrutinib-matching placebo.
Study: NCT06055972

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Educational Letter Post CT Examination
Description: Patients randomized to the CAC-based educational intervention will receive an educational letter within 8 weeks of CT examination which will include the following:~1. Their calcium score, brief educational content explaining what the calcium score means and how the presence of coronary calcifications is associated with an increased risk of a cardiac event.~2. Guidance on what actions could be taken to decrease the risk of a heart event, including blood cholesterol management, smoking cessation, weight loss, dieting, exercise, and blood pressure control.~3. For patients with CAC\>0, the letter will encourage the patient to pursue a shared decision- making discussion with his/her primary care physician or cardiologist regarding risk reduction strategies.~4. Links to American Heart Association (AHA) and phone number for study research coordinator.
Study: NCT05220865

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Hall Technique
Description: * Only food scraps or debris will be removed from the caries cavity.~* The smallest crown size will be selected that covers all cusps and approaches the contact points with a slight springback feel.~* If the contact points are tight, orthodontic elastic separators will be placed through the contacts and the SSC will be placed at the second appointment 3-5 days later.~* The SSC will be loaded with glass ionomer luting cement and placed evenly on the tooth.~* The child will be asked to bite firmly until the crown is pushed down over the tooth.~* If the child is unable or unwilling to bite down on the SSC, finger pressure will be used to seat the crown~* The child will continue to bite on a cotton roll until the cement hardens~* Excess glass ionomer cement will be removed from the crown margins with hand instruments and dental floss.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Modified Hall Technique
Description: * Food scraps or debris will be cleaned from the caries cavity and infected soft carious dentin tissue will be excavated with hand instruments.~* The smallest crown size will be selected that covers all cusps and approaches the contact points with a slight springback feel.~* If the contact points are tight, orthodontic elastic separators will be placed through the contacts and the SSC will be placed at the second appointment 3-5 days later.~* The SSC will be loaded with glass ionomer luting cement and placed evenly on the tooth.~* The child will be asked to bite firmly until the crown is pushed down over the tooth.~* If the child is unable or unwilling to bite down on the SSC, finger pressure will be used to seat the crown~* The child will continue to bite on a cotton roll until the cement hardens~* Excess glass ionomer cement will be removed from the crown margins with hand instruments and dental floss.
Study: NCT05432245

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Phacoemulsification combined with minimally invasive glaucoma surgery (MIGS)
Description: The cataract surgery will be performed first and if successful, only then will the MINIject be placed into supraciliary space.
Study: NCT06417203

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: spinal anesthesia with hyberbaric bupivacaine
Description: After standard ASA monitoring in the operation room, spinal anaesthesia was induced by injection of 12.5 mg hyperbaric bupivacaine into the subarachnoid space with the help of a spinal needle through the L4-5 intervertebral space.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: spinal anesthesia with hypobaric bupivacaine
Description: After standard ASA monitoring in the operation room, spinal anaesthesia was induced by injection of 12.5 mg hyperbaric bupivacaine into the subarachnoid space with the help of a spinal needle through the L4-5 intervertebral space.
Study: NCT05062031

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Defocus Incorporated Multiple Segments® (DIMS®) lenses
Description: Daily wear for 24 months. Lenses have a central monofocal optical zone correcting spherical or spherocylindrical ametropia, surrounded by a ring made up of 300 defocusing pellets. This lens geometry reduces the phenomenon of blurred image projected in the retinal periphery, encountered when myopic eyes are corrected with monofocal lenses.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Atropine 0.05% eyedrops
Description: One drop each evening in both eyes for 24 months.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Monofocal lenses
Description: Daily wear for 24 months
Study: NCT05645055

Intervention type: OTHER
Intervention: treat these patients with biologics
Description: treat these patients with biologics
Study: NCT05627349

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: wrist splinting
Description: standard wrist splinting at night for 2 weeks

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FSN
Description: FSN is a single-use disposable needle(Trocar Acupuncture Needle, Nanjing FSN Medical Co. , Ltd, China.). The needle body is solid, and covered with a plastic tube. The needle penetrates the skin with insertion device. Under the guidance of ultrasound, the needle enter the loose subcutaneous layer obliquely without penetrating into the muscle. This is the difference from traditional acupuncture. The insertion point is midpoint of the anterior forearm. The needle tip is toward the carpal tunnel. After the needle is inserted, SM and RA are performed. The frequency of SM is 200 times in two minutes. The method of SM is to make a horizontal fan swaying with the base of the needle as the fulcrum. RA is performed while SM-slowly make a fist for 10 seconds and then relax for 5 seconds. Eight times of RA in two minutes. After the FNS treatment, the needle was withdrawn.
Study: NCT06670755

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ID93/GLA-SE
Description: ID93/GLA-SE is a protein-adjuvant vaccine which has been purposefully designed to elicit a diverse immune response against M.tb bacterial antigens, improve treatment outcomes and prevent TB disease in people already infected with M.tb.~ID93/GLA-SE will be administered intramuscularly.
Study: NCT06520995

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Educational video program
Description: Diabetes education video contents are as follows; Type 2 diabetes definition, symptoms and the effect of diabetes on cognitive functions, Medical nutrition therapy and healthy nutrition recommendations in Type 2 diabetes, The importance of diabetes and exercise, Oral antidiabetic treatments, Insulin treatment, Hypoglycemia symptoms, findings and treatment, Macrovascular complications in diabetes, Microvascular complications in diabetes, Foot Protection and care recommendations, Diabetes self-care skills and problem-solving strategies, Diabetes and stress management.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Educational video program
Description: Diabetes education video contents are as follows; Type 2 diabetes definition, symptoms and the effect of diabetes on cognitive functions, Medical nutrition therapy and healthy nutrition recommendations in Type 2 diabetes, The importance of diabetes and exercise, Oral antidiabetic treatments, Insulin treatment, Hypoglycemia symptoms, findings and treatment, Macrovascular complications in diabetes, Microvascular complications in diabetes, Foot Protection and care recommendations, Diabetes self-care skills and problem-solving strategies, Diabetes and stress management.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: A mobile application
Description: This mobile application is a science-based application that patients can access via their smartphone or tablet. It consists of verbal, numerical, visual, logical, memory and attention categories and contains 24 different gamified mind exercises
Study: NCT04379973

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lipiodol Ultra Fluide®
Description: Tubal flush with 5-10mL oil-soluble contrast medium (OSCM) (Lipiodol Ultra Fluide®, Guerbet, France) immediately after Hyfosy. The use will be off-label.
Study: NCT06670755

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ID93/GLA-SE
Description: ID93/GLA-SE is a protein-adjuvant vaccine which has been purposefully designed to elicit a diverse immune response against M.tb bacterial antigens, improve treatment outcomes and prevent TB disease in people already infected with M.tb.~ID93/GLA-SE will be administered intramuscularly.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BCG Danish
Description: BCG Danish 1331 is on the WHO list of pre-qualified vaccines and has a well-defined side effect profile. BCG is licensed for delivery via the intradermal route. It is not licensed for delivery via the aerosol route.~For the challenge, aerosol BCG will be administered via nebulizer.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BCG Danish
Description: BCG Danish 1331 is on the WHO list of pre-qualified vaccines and has a well-defined side effect profile. BCG is licensed for delivery via the intradermal route. It is not licensed for delivery via the aerosol route.~For the challenge, aerosol BCG will be administered via nebulizer.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BCG Danish
Description: BCG Danish 1331 is on the WHO list of pre-qualified vaccines and has a well-defined side effect profile. BCG is licensed for delivery via the intradermal route. It is not licensed for delivery via the aerosol route.~For the challenge, aerosol BCG will be administered via nebulizer.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BCG Danish
Description: BCG Danish 1331 is on the WHO list of pre-qualified vaccines and has a well-defined side effect profile. BCG is licensed for delivery via the intradermal route. It is not licensed for delivery via the aerosol route.~For the challenge, aerosol BCG will be administered via nebulizer.
Study: NCT05799378

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydroxychloroquine
Description: Hydroxychloroquine 200mg capsules. Administered orally.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Hydroxychloroquine-matching placebo capsule. Administered orally.
Study: NCT05393570

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Healthy Lifestyle Behavioral Intervention (MBS -supported intervention)
Description: After patient/parent consent is completed, participants will begin the pre-MBS intervention phase. A minimum of 6 1- hour sessions will occur pre-MBS, and 26 will occur post-MBS.Dr. Klement, MBS coordinator and a diabetes educator will manage session delivery to adolescents/parents. All content will follow the Diabetes Prevention Program (DPP)-adapted curriculum flow. After that the research assistant will perform outreach, reminder calls, and follow-up for missed appointments. Pre-and post-MBS intervention delivery (based on adapted curriculum/model) may consist of a combination of 1-on-1 and group sessions (in-person or virtually), and online support tools, dependent upon adolescent/parent qualitative feedback on delivery method preference.
Study: NCT05225324

Intervention type: DRUG
Intervention: Equfina 50 mg
Description: Equfina 50 mg tablets.
Study: NCT06673524

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Group T (Transversus Abmoninis Plane Block)
Description: TAP Block: Aseptic conditions are ensured in the area where the block will be performed. With the patient in the supine position, the ultrasound (USG) probe is placed in an oblique position lateral to the xiphoid process at the lower border of the rib cage. The rectus abdominis muscle and its posterior sheath are visualized above the transversus abdominis muscle. At this level, only the aponeurosis of the internal oblique muscle can be seen between the transversus and external oblique muscles. By applying some pressure and tilt to the probe, the image of the myofascial planes is better optimized. Using a 22-25G, 50-100 mm block needle, an in-plane technique is applied, advancing either medially to laterally or vice versa. In the fascial plane between the rectus abdominis and transversus abdominis or between the internal oblique and transversus abdominis muscles, 20 ml of 0.25% bupivacaine is injected. The same procedure is then applied to the opposite side.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Group R (Rectus-Intercostal Fascial Plane Block)
Description: Rectus-Intercostal Fascial Plane Block: Aseptic conditions are ensured in the area where the block will be performed. With the patient in the supine position and under ultrasound (USG) guidance, a linear probe is placed 2-3 cm lateral and caudal to the xiphoid process to visualize the rectus abdominis muscle and the 6th-7th costal cartilages. Using an in-plane technique, the needle is advanced from caudal to cephalad. After confirming the target by hydrodissecting between the ribs and the rectus abdominis muscle, 20 ml of 0.25% bupivacaine is injected into the interfascial plane between the 6th-7th ribs and the rectus abdominis muscle using a 22-G, 80 mm block needle. The same procedure is then applied to the opposite side.
Study: NCT05866471

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: The psilocybin is produced under Good Manufacturing Practice and is in a capsule that contains 25 mg of botanically-derived psilocybin.

Intervention type: DRUG
Group type: SHAM_COMPARATOR
Intervention: Psilocybin
Description: The psilocybin is produced under Good Manufacturing Practice and is in a capsule that contains 25 mg of botanically-derived psilocybin.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Psilocybin
Description: The psilocybin is produced under Good Manufacturing Practice and is in a capsule that contains 25 mg of botanically-derived psilocybin.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Psilocybin
Description: The psilocybin is produced under Good Manufacturing Practice and is in a capsule that contains 25 mg of botanically-derived psilocybin.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneous auricular Vagus Nerve Stimulation (taVNS)
Description: For both the active and sham taVNS procedure, participants will be provided with, and trained on, taVNS devices that apply gentle stimulation to the left ear via either electrodes or an earpiece that fits over the left ear.
Study: NCT06634563

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mindfulness meditation
Description: the patients will receive mindfulness meditation in the form of Attention-focusing technique (body scan, directing attention throughout the body in a relaxed, supine state) guided by audiotapes. Relaxing every part of the body by guided audiotape from head to toes and Sitting meditation (systematically directing attention to breath) guided by audiotapes. Relaxing deep rhythmic breathing with concentration on every breath.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: cognitive behavioral training
Description: Training sessions will include three cognitive training tasks each of them target a particular core cognitive capability and are grouped into three categories by target domain: memory (working memory), attention (selective attention), and problem solving (logical reasoning) through these games (organic order and fuse clues for logical reasoning training, lost in migration, trouble brewing, assist ants and train of thought for attention training and memory match and memory match one drive for working memory training).
Study: NCT04859647

Intervention type: OTHER
Group type: OTHER
Intervention: Method of Levels Therapy
Description: MOL is a flexible, client-led psychological therapy that allows people to talk freely about important problems and life goals.
Study: NCT05284474

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF)
Description: soluble fms-like tyrosine kinase to placental growth factor ratio (sFlt-1/PlGF) will be incorporated to the management of early-onset small fetuses (estimated fetal weight ≤10th percentile)
Study: NCT06634563

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: cognitive behavioral training
Description: Training sessions will include three cognitive training tasks each of them target a particular core cognitive capability and are grouped into three categories by target domain: memory (working memory), attention (selective attention), and problem solving (logical reasoning) through these games (organic order and fuse clues for logical reasoning training, lost in migration, trouble brewing, assist ants and train of thought for attention training and memory match and memory match one drive for working memory training).
Study: NCT05233371

Intervention type: OTHER
Intervention: Parenting Stress Index (PSI)
Description: collected by self-questionnaire during the follow-up carried out within the framework of the usual care (at 4, 9, 24 months of corrected age, +/- 18 months according to the neurodevelopmental evolution).~Parental stress will be measured at each visit with the same parent (father or mother).

Intervention type: OTHER
Intervention: Collection of health care consumption
Description: Type and number of health professionals consulted between the different visits scheduled as part of the usual follow-up of the Dijon Bourgogne University Hospital,~* Frequency and duration of rehabilitation sessions by type of health professionals,~* Follow-up methods (institutional or private),~Consumption of care will be evaluated by means of self-questionnaires given to parents during follow-up consultations as part of the usual care.

Intervention type: OTHER
Intervention: Assessment of parent satisfaction
Description: their level of information, their child's follow-up, and the support provided by the professionals.~Satisfaction will be evaluated by means of a self-questionnaire (Likert scale) given to parents during follow-up consultations as part of their usual care.
Study: NCT06060639

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: transthoracic echocardiography
Description: E wave, A wave, e' and vdi measurement