TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06790524

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: One-piece dental implants with MUA
Description: one-piece dental implants with multi-units abutment mounted on the implants as a single piece provided with different abutment angulation utilizing these implants for All-On-Four prothesis

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Two-piece dental implants
Description: Surgical and immediate loading procedures:~On the day of implant placement, patients will receive two-piece implant. After crestal incision and full-thickness flap elevation, the implant sites will be prepared aided by a surgical template. 4 implants will be placed, two aligned in an axial orientation and two will be distally aligned (17 degrees). The standard placement procedure as recommended by the manufacturer will be used. The surgical drills with increasing diameters will be used to prepare the implant sites. Implants will be ideally placed at bone level (or 1 mm deeper depending on the soft tissue thickness). After 3 months as a healing phase, a definitive prosthesis will be fabricated using the same abutments, and the marginal bone loss after the osseointegration phase will be assessed.
Study: NCT06790641

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Program in Support of Moms (PRISM)
Description: Program in Support of Moms (PRISM): a practice-level intervention with implementation support that helps obstetric practices integrate mental health care for perinatal individuals. To help obstetric practices implement pathways for screening, assessment, and a stepped intervention response for mental health problems and social determinants of health. PRISM offers training in trauma informed and equitable care, technical assistance, and implementation and change management support.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Program in Support of Moms (PRISM)
Description: Program in Support of Moms (PRISM): a practice-level intervention with implementation support that helps obstetric practices integrate mental health care for perinatal individuals. To help obstetric practices implement pathways for screening, assessment, and a stepped intervention response for mental health problems and social determinants of health. PRISM offers training in trauma informed and equitable care, technical assistance, and implementation and change management support.
Study: NCT06310317

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Applied Behavior Analysis protocol
Description: The main objective of the experimental protocol is to promote the development of cognitive skills, facilitate the acquisition of new skills and promote the adoption of functional and adaptive behaviors. The use of Applied Behavior Analysis procedures, with the help of technological tools such as a tablet or robot can facilitate the increase of new knowledge and skills.~The criterion is acquired if the subject emits 8 out of 10 independent correct responses (90%) for 3 consecutive sessions.~The objective is to test whether the technological tool used (tablet or robot) can make the proposed learning procedure more effective. The experimental group carries out the procedure by means of stimuli presented on tablets or robots.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Traditional intervention
Description: The main objective of the experimental protocol is to promote the development of cognitive skills, facilitate the acquisition of new skills and promote the adoption of functional and adaptive behaviors. In this group the materials are traditional, such as image printed. The criterion is acquired if the subject emits 9 out of 10 independent correct responses (90%) for 3 consecutive sessions. The control group performs the procedure with images printed on A4 laminated sheets.
Study: NCT05113017

Intervention type: OTHER
Intervention: NO Intervention
Description: NO Intervention
Study: NCT04974697

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: JJVC Investigational Multifocal Toric Contact Lens
Description: TEST
Study: NCT04856189

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selinexor
Description: Given PO
Study: NCT06404502

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PRISMA
Description: PRISMA has been developed adapting PM+, a brief, psychological intervention program based on CBT techniques that are empirically supported and formally recommended by the WHO. The adapted manual was developed to tailor the sessions to the structure of the Swiss prison system and the needs of inmates of jails in Switzerland. PRISMA involves the following elements: stress management, problem-solving, meaningful activities and relapse prevention~PRISMA has four core features:~* Evidence-based problem-solving strategies~* Brief and easy to learn~* Delivered by lay-helpers (trainers)~* Transdiagnostic, addressing depression, anxiety, stress, and practical problems as defined by participants;~PRISMA has four sessions.
Study: NCT06790641

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: PSI Peer Support
Description: Postpartum Support International (PSI) Peer Support: a service administered by PSI that pairs perinatal individuals with a volunteer peer mentor who provides support, psychoeducation, behavioral activation, and navigation services, which includes planning, goal setting, and practical tools to manage parenting and mental health symptoms.
Study: NCT06791317

Intervention type: OTHER
Intervention: Checklist
Description: A checklist for the intubation procedure was organised into the categories physiological optimisation, equipment and drugs, team line-up, and contingency plan. This checklist was implemented in the clinic.

Intervention type: OTHER
Intervention: Checklist
Description: A checklist for the intubation procedure was organised into the categories physiological optimisation, equipment and drugs, team line-up, and contingency plan. This checklist was implemented in the clinic.
Study: NCT06791655

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Stock Abutment Implant
Description: Participants in this intervention group receive a two-piece dental implant that utilizes a stock abutment. The stock abutment is a prefabricated component that connects the implant to the prosthetic suprastructure. This intervention aims to evaluate the standard outcomes of using stock abutments in the restoration of teeth in esthetic zones after immediate implant placement.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Customized CAD CAM Titanium Milled Abutment Implant
Description: Participants in this intervention group are treated with a two-piece dental implant that includes a customized CAD CAM titanium milled abutment. These abutments are tailor-made using computer-aided design and manufacturing to fit the specific contours and needs of the patient's dental structure. This customized approach is hypothesized to offer superior integration with the soft and hard tissues, leading to better aesthetic outcomes and tissue health around the implant area.
Study: NCT06790914

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Flurbiprofen axidate combined with noise-cancelling headphones music
Description: 30min before induction of general anesthesia, flurbiprofen axidate 50mg+ normal saline 50ml at 60 drops /min; After general anesthesia induction, noise-cancelling headphones (Sony WH-1000XM3) were fully covered with both ears, and MP3 (GoGear, Philips) was connected to play music continuously until the headphones were removed after the operation.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Flurbiprofen axidate combined with noise-cancelling headphones
Description: 30min before induction of general anesthesia, flurbiprofen axidate 50mg+ normal saline 50ml at 60 drops /min; After induction of general anesthesia, noise-cancelling headphones (Sony WH-1000XM3) were applied to cover both ears completely until the headphones were removed at the end of the procedure.
Study: NCT05281211

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nutrition
Description: 6 weeks nutrition implementation in the form of branched chain amino acids and immune-system boosters twice daily for 4 weeks and once daily for 2 weeks

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: 6 weeks exercise 30 minutes' walk/day or 2000 extra steps daily
Study: NCT04959916

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Group Metacognitive Therapy
Description: Group Meta-Cognitive Therapy (Group-MCT) will consist of six weekly sessions delivered by two trained trainee clinical psychologists over 1-1.5 hours. The aims of the intervention are to help participants develop knowledge that can facilitate control of worry, rumination and attention, and to modify the metacognitive beliefs that maintain these unhelpful patterns of thinking. The treatment follows a manual that has been previously evaluated in the treatment of cardiac patients suffering from anxiety and depression. Sessions include group discussions, experiential learning and homework tasks that participants will be expected to complete between sessions.
Study: NCT05532761

Intervention type: OTHER
Intervention: self-administered questionnaires
Description: In order to describe the experience of CAR-T cell therapy of DLBCL patients, a pharmaceutical follow-up is carried out the day before the injection (baseline) and at 1, 3, 6, 9, 12 and 18 months. These follow-ups consist of interviews with the patient and the delivery of self-administered questionnaires. The interviews will investigate drug consumption, the use of self-medication and complementary alternative therapies and the adverse effects of interest. The self-questionnaires will focus on exploring multidimensional quality of life, social and professional life, anxiety-depression or uncertainty tolerance through internationally validated questionnaires.~No supplementary visits will be needed : interviews with the research team will occur at the end of hematologic consultations.
Study: NCT05810883

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Tests; Serum Fasting Insulin and Glucose
Description: Laboratory results of blood samples, for high-density lipoprotein (HDL), low-density protein (LDL), triglycerides, and total cholesterol (TC) will be evaluated for this study. Fasting Insulin and fasting glucose levels will be used to calculate IR.~Insulin Resistance will be calculated using Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (FPG (mmol/L) × FPI (mU/L)/22.5) \[21\] and defined as HOMA-IR ≥ 3.4

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Tests; Serum Fasting Insulin and Glucose
Description: Laboratory results of blood samples, for high-density lipoprotein (HDL), low-density protein (LDL), triglycerides, and total cholesterol (TC) will be evaluated for this study. Fasting Insulin and fasting glucose levels will be used to calculate IR.~Insulin Resistance will be calculated using Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) (FPG (mmol/L) × FPI (mU/L)/22.5) \[21\] and defined as HOMA-IR ≥ 3.4
Study: NCT04778930

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical Therapy
Description: FACE-TO FACE SESSIONS: approximately 90 minutes of Goal-directed training (activities for the activation of the muscles of the trunk, pelvis and lower limbs; and training of activities will be carried out in a functional and meaningful context, aimed at specific functional objectives, according to the interests of each participant and agreed with the participants and their families) and gait training on the treadmill for 20 minutes.~TELEHEALTH THERAPEUTIC EDUCATION PROGRAM: Session 1: Concept and causes of CP, together with the general objectives and guidelines of the program. Session 2: The family-centered model; Sessions 3, 4 and 5: Actions Observation Therapy; Session 6: Program Evaluation.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: THERAPEUTIC EDUCATION PROGRAM
Description: TELEHEALTH THERAPEUTIC EDUCATION PROGRAM: Session 1: Concept and causes of CP, together with the general objectives and guidelines of the program. Session 2: The family-centered model; Sessions 3, 4 and 5: Actions Observation Therapy; Session 6: Program Evaluation.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: THERAPEUTIC EDUCATION PROGRAM
Description: TELEHEALTH THERAPEUTIC EDUCATION PROGRAM: Session 1: Concept and causes of CP, together with the general objectives and guidelines of the program. Session 2: The family-centered model; Sessions 3, 4 and 5: Actions Observation Therapy; Session 6: Program Evaluation.
Study: NCT04729270

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Physiotherapy treatment with physium device.
Description: The intervention for this group consisted of 10 sessions with Transcranial Direct Current Stimulation for a month.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Conventional physiotherapy treatment.
Description: The intervention for this group consisted of 10 sessions with Electrical Nerve Stimulation (TENS) for a month.
Study: NCT06790914

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Flurbiprofen exate on a drip
Description: 30min before induction of general anesthesia, flurbiprofen axidate 50mg+ normal saline at 60 drops /min.
Study: NCT06791681

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ESO-T01
Description: ESO-T01 injection is the third-generation self-inactivating lentiviral vector targeting T cells in vivo, which carries a single VHH-directed BCMA-targeted CAR.
Study: NCT06791603

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standardized chemotherapy education + video
Description: Videos will be provided with patients and they will watch videos during the visit. The information regarding the prevention and management of side effects and further instructions when to visit hospital. Patients will have access to videos and watch videos after leaving the hospital for the entire treatment course
Study: NCT06791993

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Capsule
Description: Participants will receive an inert placebo capsule that matches the probiotic capsule in size, shape, and color. The placebo will be administered orally twice daily, starting 2 weeks before surgery and continuing for 2 weeks postoperatively.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic with Human Milk Oligosaccharides (HMO)
Description: Participants will receive a dual-strain probiotic containing Human Milk Oligosaccharides (HMO) in capsule form. The probiotic will be administered orally twice daily, starting 2 weeks before surgery and continuing for 2 weeks postoperatively.
Study: NCT06783647

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LBL-024 for Injection
Description: Q3W; intravenous infusion;Each infusion is usually completed within 30-120 minutes

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LBL-024 for Injection
Description: Q3W; intravenous infusion;Each infusion is usually completed within 30-120 minutes

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Docetaxel Injection
Description: Q3W; intravenous infusion;Each infusion is usually completed in about 60 minutes.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab Injection
Description: Q3W; intravenous infusion;Infusion time between 30 and 90 minutes.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pemetrexed Disodium for Injection
Description: Q3W; intravenous infusion；Each infusion was over 10 minutes.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel Injection
Description: Q3W; intravenous infusion;The infusion time was more than 3 hours each time.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin Injection
Description: Q3W; intravenous infusion;The infusion time is at least 30 minutes for each infusion.
Study: NCT06791954

Intervention type: OTHER
Group type: OTHER
Intervention: Exercise
Description: Clinical pilates program

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercise
Description: Clinical pilates program
Study: NCT06792045

Intervention type: OTHER
Intervention: Physiotherapist assessment
Description: * Tongue motor skills (Tongue pressures and tongue mobility, assessed through the Iowa Oral Performance Instrument and the Motricité Bucco-Linguo-Faciale tongue subscore, respectively)~* Tongue restriction of mobility due to its frenulum (assessed through the Quick Tongue-Tie assessment tool)~* Breathing Pattern (questionnaire from Abreu RR, Rocha RL, Lamounier JA, Guerra AF. Etiology, clinical manifestations and concurrent findings in mouth-breathing children. J Pediatr (Rio J). 2008;84(6):529-535.).

Intervention type: OTHER
Intervention: ENT assessment
Description: Data from the ENT appointment will be collected (e.g., sex, height, weight)

Intervention type: DIAGNOSTIC_TEST
Intervention: Drug-Induced Sleep Endoscopy
Description: A Drug-Induced Sleep Endoscopy will be performed, recorded, and evaluated by two blinded raters using the IPSES scale.
Study: NCT06792565

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: hemodializer
Description: Fresenius Helixone FX5 (61346 Bad Homburg, Germany)

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: hemofilter
Description: Medica (741036 Medolla, Italy)
Study: NCT06792630

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: laughter therapy intervention
Description: In addition, patients in the intervention group were given laughter therapy intervention from the 1st day of HSCT, with the mnemonic hihihi (pinyin spelling), hahahaha, eggplant eggplant eggplant, qixi qixi qixi qixi, hahahahahahahahaha, 30 times of the mnemonic as a training session, once a day, from the beginning of the transplantation transfusion +1d to the end of the transplantation transfusion +1d, and then to the end of the transplantation. Patients were discharged from the warehouse, and after discharge, patients were centralized on-line laughter therapy intervention, 1 time/week, repeating 30 times of mnemonics, until 1 year after transplantation.
Study: NCT06791980

Intervention type: OTHER
Group type: OTHER
Intervention: CM-TCM
Description: To assess the long-term effects of integrated case management model involving traditional Chinese medicine (CM-TCM) model. The persons participating will be invited to enroll in this stage, and they will be assigned to receive either the usual care or a usual care plus integrated 3-month CM-TCM
Study: NCT06790940

Intervention type: OTHER
Intervention: No intervention
Description: This is an observational study, no intervention will be implemented.

Intervention type: OTHER
Intervention: No intervention
Description: This is an observational study, no intervention will be implemented.
Study: NCT06790784

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Vitrectomy
Description: The vitrectomy must occur within 4 weeks of randomization. A single injection of faricimab is allowed at any point before the vitrectomy. It is recommended that this injection is within 1 week of the vitrectomy. Requirement of triamcinolone staining to assist in complete elevation and removal of the posterior hyaloid and in removal of as much peripheral vitreous as is safely possible, 20 gauge not permitted. Allows subconjunctival steroid at investigator discretion; however, sub-tenon's triamcinolone or other long-acting steroid will not be permitted.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Endolaser
Description: Complete panretinal photocoagulation (PRP) during vitrectomy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Faricimab
Description: Treatment must be initiated on the day of randomization with one faricumab injection. The remainder of the randomized treatment includes 2 additional injections every 4-weeks. Injections must be completed within 90 days of randomization.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Panretinal Photocoagulation (PRP)
Description: Complete PRP. PRP may be completed in 1-3 sessions, with the timing at the investigator's discretion. All PRP sessions must be completed within 90 days of randomization.
Study: NCT06791850

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: HF-FamPALhomeCARE
Description: Participants in HF-FamPALhomeCARE Intervention group receive standard care plus 2 home visits, 3 bi-weekly telephone call on HF home EOLPC care, and follow-up telephone calls at 3, 6, 9, and 12 months.
Study: NCT06791161

Intervention type: DRUG
Intervention: Endocrine drug +CDK4/6 inhibitor or PRAP inhibitor or Endocrine drug +CDK4/6 inhibitor+PARP inhibitor
Description: BRCA1/2 mutated hormone receptor-positive HER2-negative early high-risk breast cancer is treated with 3 3 treatment options after surgery：Endocrine drug +CDK4/6 inhibitor or PRAP inhibitor or Endocrine drug +CDK4/6 inhibitor+PARP inhibitor
Study: NCT06790407

Intervention type: DIETARY_SUPPLEMENT
Intervention: Mimio Study Product
Description: Active ingredients in the Mimio study product include Nicotinamide 250mg, Ultra-Micronized Palmitoylethanolamide 600mg, Oleoylethanolamide 400mg, Spermidine 8mg; Other Ingredients: Hydroxypropyl-Methylcellulose (capsule), Silicon Dioxide, Magnesium Stearate.

Intervention type: DIETARY_SUPPLEMENT
Intervention: Placebo
Description: Non-active study ingredients in the placebo include Micro Crystalline Cellulose 250mg, Hypromellose, Titanium Dioxide.
Study: NCT06790472

Intervention type: BEHAVIORAL
Intervention: Online Lifestyle Intervention
Description: The Metabolic Wellness Program (MWP) is an established 8-week program that provides participants with health education videos and webinars that focus on evidence-based nutrition, fitness, sleep, and stress intervention, including with CGM, allowing participants to monitor their real-time glucose data and to learn which lifestyle choices are best for their glycemic control and personal metabolic health. The program is also intended to help healthy participants maintain their metabolic health and lower their potential risk of developing cardiometabolic disease, as well as at-risk and pre-diabetic participants preventing the progression to T2D and people with established T2D reverse their condition.

Intervention type: DEVICE
Intervention: Continuous Glucose Monitoring
Description: CGM measurements begin at enrollment with training provided digitally Participants will be asked to live life as usual whilst wearing the device with initial 10-14 day readings providing baseline data. Participants will participate in the online lifestyle program, which the investigators refer to as the intervention stage. Participants will also receive questionnaires on behavior change at the beginning of week 5. During the final two weeks of the program (weeks 7-8), the final 10-14 days of CGM will be used as comparison data with baseline information.
Study: NCT06791148

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Low-dose radiotherapy
Description: 2Gy/f，q3w，×4f

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: albumin-bound paclitaxel
Description: 100-120mg/m2,i.v.,d2,d9,q3w

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AK112
Description: 20mg/kg, i.v., d2, q3w