TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04733404

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dragonfly Transcatheter Mitral Valve Repair System
Description: To conduct edge-to-edge repair with Dragonfly System under the guidance of transesophageal echocardiography.
Study: NCT04985331

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: W-GenZD
Description: W-GenZD is a program that delivers evidence based therapy for the symptoms of mild-moderate depression and anxiety in adolescents in brief conversations with a fully automated relational agent.
Study: NCT06546085

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: Supervised treadmill exercise at 85% VO2max, 3x/wk for 16 weeks. Exercise duration will be adjusted based on individual VO2-heart rate (HR) relationship so that \~400 kcals will be expended during each training session.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: Supervised treadmill exercise at 85% VO2max, 3x/wk for 16 weeks. Exercise duration will be adjusted based on individual VO2-heart rate (HR) relationship so that \~400 kcals will be expended during each training session.
Study: NCT03717246

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Sleep Smart Latino
Description: A culturally tailored group intervention aimed at improving sleep duration and quality for Latino middle school students.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Basic Sleep Hygiene and Child Health
Description: A group intervention providing sleep hygiene and child health topics education to Latino middle school students.
Study: NCT05801913

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Anti-CD19-CAR CMV-specific T-lymphocytes
Description: Given IV

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Biopsy
Description: Undergo bone marrow biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT
Study: NCT05624593

Intervention type: DEVICE
Group type: OTHER
Intervention: P200TE
Description: The P200TE Ophthalmoscope provides widefield Scanning Laser Ophthalmoscope (SLO) fundus imaging and Optical Coherence Tomography (OCT) imaging in one device.

Intervention type: DEVICE
Group type: OTHER
Intervention: Predicate
Description: The predicate device is an optical coherence tomography system intended for in vivo imaging, axial cross-sectional, three-dimensional imaging and measurement of anterior and posterior ocular structures.
Study: NCT05108480

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental group
Description: This study followed the protocol designed for patients with hemophilic knee arthropathy. For its implementation, a 30-cm long15-cm diameter foam roller was used, and a ball 22 cm in length and 8 cm in diameter. The total duration of the intervention was 15 minutes, with 7 sessions per week over a period of 8 weeks. The physiotherapist who supervised the intervention followed up on all patients by telephone on a weekly basis to check for the absence of haemarthrosis during the intervention and to detect the possible need for protocol adaptations depending on the clinical situation of each patient. Each patient was individually provided with instructions as to how perform the exercises during the pretreatment evaluation, customizing the program if necessary. All patients had access to a mobile application, designed ad hoc for the research study (He-Foam®), where they could learn about the exercises through demonstration videos.
Study: NCT06005298

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Screening, Brief Intervention, Referral to Treatment (SBIRT)
Description: SBIRT has been defined by SAMHSA as a comprehensive, integrated, public health approach to the delivery of early intervention for individuals with risky alcohol and drug use and the timely referral to more intensive substance abuse treatment for those who have substance abuse disorders. There is consensus that a comprehensive SBIRT model includes screening, brief intervention/brief treatment, and referral to treatment. In addition there are following characteristics:~* It is brief (e.g., typically about 5-10 minutes for brief interventions; about 5 to 12 sessions for brief treatments)~* The screening is universal.~* One or more specific behaviors related to risky alcohol and drug use are targeted.~* The services occur in a public health non-substance abuse treatment setting.~* It is comprehensive (comprised of screening, brief intervention/treatment, and referral to treatment).~* Strong research or experiential evidence supports the model's effectiveness.
Study: NCT05801913

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Leukapheresis
Description: Undergo leukapheresis per SOC

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lymphodepletion Therapy
Description: Undergo lymphodepletion chemotherapy per SOC

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Multi-peptide CMV-Modified Vaccinia Ankara Vaccine
Description: Given IM

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo PET

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: X-Ray Imaging
Description: Undergo x-ray
Study: NCT04901533

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: O-A-A
Description: patient is supine, and the therapist stands on the side to be manipulated. The cranial hand of the therapist globally grasps the patient's skull and turns the patient's neck on that same side. The caudal hand is placed on the patient's face. The technique is performed by an impulse in pure rotation on the side that the cervical region is rotated, with a helical movement.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: cranial listening
Description: The patient is in the supine position, and the therapist sitting at the head of the patient. The therapist places his hands on the head of the patient, the thumbs touch each other, without touching the vault cranial. A perception of the cranial rhythm is carried out passively.
Study: NCT03565848

Intervention type: PROCEDURE
Intervention: Mesenteric vascular and nerve sparing surgery in laparoscopic segmental colorectal resection
Description: Laparoscopic segmental colorectal resection performed by dissecting adherent to the intestinal wall with mesenteric vascularization and innervation entirely preserved.
Study: NCT06501911

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity-modulated radiation therapy (IMRT)
Description: Participants will receive 35 Gy delivered in 10 fractions, administered once daily on weekdays.
Study: NCT06290271

Intervention type: OTHER
Intervention: Intracranial artery flow pattern
Description: the cerebral blood flow patterns observed after the occluded artery has been recanalized.

Intervention type: OTHER
Intervention: Intracranial artery flow pattern
Description: the cerebral blood flow patterns observed after the occluded artery has been recanalized.
Study: NCT04441879

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Be a Mom Coping with Depression
Description: Be a Mom Coping with Depression is a blended cognitive-behavioral intervention for the treatment of postpartum depression. It consists of 13 weeks of face-to-face and online sessions, each session targeting a specific thematic content, and providing participants with both information and specific therapeutic strategies (with a strong focus on cognitive-behavioral techniques) to address each thematic content.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Be a Mom
Description: Be a Mom is an online intervention consisting of 6 modules, each one targeting a specific thematic content, and providing women with both information and specific therapeutic strategies (with a strong focus on cognitive-behavioral techniques) to address each thematic content. Women will receive biweekly phone calls from a psychologist between completion of each module to provide support.
Study: NCT06490198

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: OBI-833/OBI-821
Description: OBI-833 is a glycoconjugate that consists of Globo H, a unique tumor-associated carbohydrate antigen (TACA), covalently linked to cross-reacting material 197 (CRM197), an inactive and nontoxic form of diphtheria toxin (DT) acting as the carrier protein.~OBI-821 is a saponin-based adjuvant derived from the bark of the Quillaja saponaria Molina tree. It is a purified saponin adjuvant structurally similar to adjuvant QS-21. The OBI-833/OBI-821 combination represents a carbohydrate-conjugate vaccine combined with an immune adjuvant, intended to serve as an active cancer immunotherapy.
Study: NCT04968340

Intervention type: PROCEDURE
Group type: OTHER
Intervention: conventional cs
Description: opening the lower uterine segment with introduction of the surgeon hand below the fetal head during its extraction

Intervention type: PROCEDURE
Group type: OTHER
Intervention: external pop out teqnique
Description: support of lower uterine segment without introduction of the surgeon hand below the fetal head during its extraction
Study: NCT04908917

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Portable Air Cleaner with a HEPA Filter
Description: A novel intervention using a portable air cleaner with HEPA filter to treat mildly high BP to potentially reduce the cardiovascular effects of PM2.5. Leave the PAC running with the HEPA filter installed on the highest setting during sleeping periods in the room in which the participant sleeps.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Portable Air Cleaner without a HEPA Filter
Description: Leave the PAC running without a HEPA filter installed on the highest setting during sleeping periods in the room in which the participant sleeps.
Study: NCT05018520

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Six Courses of R-CHOP Plus Two Courses of Rituximab
Description: The patients will be given RCHOP (Rituximab 375mg/m2 ivgtt, D0, Cyclophosphamide 750mg/m2, ivgtt D1, doxorubicin 50mg/m2,ivgtt D1, Vincristine 1.4mg/m2（max 2mg）, ivgtt D1 Prednisone 60mg/m2 （max 100mg）,PO,D1-D5 every 21 days for total 6 courses) followed by Rituximab (375mg/m2 d1, every 21 days for total 2 courses)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Four Courses of R-CHOP Plus Four Courses of Rituximab
Description: The patients will be given RCHOP (Rituximab 375mg/m2 ivgtt, D0, Cyclophosphamide 750mg/m2, ivgtt D1, doxorubicin 50mg/m2,ivgtt D1, Vincristine 1.4mg/m2（max 2mg）, ivgtt D1 Prednisone 60mg/m2 （max 100mg）,PO,D1-D5 every 21 days for total 4 courses) followed by Rituximab (375mg/m2 d1, every 21 days for total 4 courses)
Study: NCT05373121

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online Peer Support
Description: Signposting to online peer support groups and forums
Study: NCT06139861

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: TranS-C
Description: Transdiagnostic Sleep and Circadian Intervention (TranS-C) is an evidence based cognitive-behavioral sleep therapy.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Psychoeducation
Description: The overarching principle is to provide information about how sleep, stress, diet, health, exercise, accidents and mood are inter-related and have reciprocal effects.
Study: NCT04185441

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tanzânia association
Description: Tanzânia association capsule

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Omnic Ocas
Description: Tamsulosin 0,4 mg

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Omnic Ocas placebo
Description: Tamsulosin placebo

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Tanzânia association placebo
Description: EMS association placebo
Study: NCT05496894

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitoxantrone Hydrochloride Liposome Injection
Description: IV, once every 3 months (Q3M)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitoxantrone Hydrochloride Liposome Injection
Description: IV, once every 3 months (Q3M)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitoxantrone Hydrochloride Liposome Injection
Description: IV, once every 3 months (Q3M)
Study: NCT04973215

Intervention type: OTHER
Intervention: no intervention
Description: this is not an intervention study

Intervention type: OTHER
Intervention: no intervention
Description: this is not an intervention study

Intervention type: OTHER
Intervention: no intervention
Description: this is not an intervention study
Study: NCT06459622

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Serum IL_25 and eosinophils in nasal polyp tisuee
Description: Serum IL-25 and eosinophils in nasal polyps tisuer obtained and measured to identify the sensitivity of nasal polyps to corticosteroids

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Serum IL_25 and eosinophils in nasal polyp tisuee
Description: Serum IL-25 and eosinophils in nasal polyps tisuer obtained and measured to identify the sensitivity of nasal polyps to corticosteroids
Study: NCT06386809

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TAVNS
Description: TAVNS is a recently introduced treatment involving transcutaneous electrical stimulation of the auricular branch of the vagus nerve with VAGUSTIM device.

Intervention type: OTHER
Group type: OTHER
Intervention: Exercise program
Description: Rocabado 6x6 exercises will be applied in our study. Rocabado exercise, which is the most commonly used exercise method in the literature, is a set of exercises for the craniocervical and craniomandibular system.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise program
Description: Rocabado 6x6 exercises will be applied in our study. Rocabado exercise, which is the most commonly used exercise method in the literature, is a set of exercises for the craniocervical and craniomandibular system.
Study: NCT06637462

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Endoscopy
Description: Standard of care endoscopy
Study: NCT05096702

Intervention type: DRUG
Intervention: Tafenoquine
Description: Tafenoquine 300 mg (2x150mg tablets)

Intervention type: DRUG
Intervention: Primaquine
Description: Daily primaquine adjusted by weight (0.5 mg/kg/day for 7 days)

Intervention type: DRUG
Intervention: Primaquine
Description: Weekly primaquine adjusted by weight (0.75mg/kg/week for 8 weeks)
Study: NCT05414370

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Liquid oxygen
Description: Liquid medical oxygen will be administered for 6 hours using high-flow nasal cannula delivery system with an Fi02 of 100% and flow rate of 60 litres per minute.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: medical air
Description: Synthetic medical air will be administered for 6 hours using high-flow nasal cannula delivery system with a flow rate of 60 litres per minute.
Study: NCT05262582

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Sigle port RATS
Description: The incision is performed in the 5-6th intercostal space under the breast folds without violating the mammalian tissue. This port is used for the camera and both arms simultaneously.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Two ports RATS
Description: The incision is performed in the 4th intercostal space along anterior axillary fossa, for the camera and left arm. The other incision is subxiphoid longitudinal incision about 4cm for the right arm.
Study: NCT06390631

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous Positive Airway Pressure
Description: Patients with COPD were recruited to breath under the atmosphere pressure and different levels of CPAP (4, 6, 8 and 10 cm H2O).
Study: NCT05271110

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Liver resection (ablation)
Description: Treatment of liver metastases from pancreatic cancer by surgery or ablation
Study: NCT04831190

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tailored Exercise Intervention
Description: The exercise program to be implemented for neuro-oncology patients will combine aerobic, resistance, balance, and flexibility exercises delivered in one-to-one setting (i.e., personal training) twice per week, for 12 weeks. Based on needs and preferences, participants will have the option to join a circuit-type group class once per week in place of one of their personal training sessions. During COVID-19, all sessions will be delivered remotely. If facilities are open and deemed safe for cancer patients, participants will have the option to attend an in-person session, integrated in the community. Whether delivered in-class or remotely, the intervention will follow exercise progression principles (i.e., frequency, intensity, time, type, overload, and progression) over the 12-weeks, with tailoring of any exercise to meet individual participant needs, with aims of promoting wellness and physical function. The exercise intervention is based on the Alberta Cancer Exercise (ACE) program.
Study: NCT04134923

Intervention type: DRUG
Intervention: [11C] Pittsburgh Compound-B (PIB)
Description: Participants will receive a single intravenous bolus injection of 6.0 - 20.0 mCi (222-740 MBq) of the investigational radiotracer \[11C\] PIB. Participants will then undergo a \[11C\] PIB PET/CT scan conducted in the Center for Clinical Imaging Research (CCIR) facility.
Study: NCT05046665

Intervention type: DRUG
Group type: OTHER
Intervention: 89Zr-Girentuximab
Description: Administration of 89Zr-girentuximab as per protocol.
Study: NCT00627835

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sorafenib
Description: Cohort 1 - sorafenib 200 mg PO bid concurrent with radiation

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sorafenib
Description: o Cohort 2 - sorafenib 400 mg PO bid concurrent with radiation

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sorafenib and cisplatin
Description: Cohort 3 - sorafenib 200 mg PO bid / cisplatin 75 mg/m2 weeks 1, 4 and 7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sorafenib and cisplatin
Description: o Cohort 4 - sorafenib 400 mg PO bid/ cisplatin 75 mg/m2 weeks 1, 4 and 7
Study: NCT04722887

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Alpha-1 15%
Description: Alpha1-Proteinase Inhibitor (Human), 15%, Subcutaneous infusion
Study: NCT04049500

Intervention type: OTHER
Intervention: Digital Diabetes Prevention Program (dDPP)
Description: dDPP tool suite to integrate with the EHR and clinical workflows
Study: NCT00627835

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sorafenib and cisplatin
Description: Cohort 5 - sorafenib 400 mg PO bid/ cisplatin 100 mg/m2 weeks 1, 4 and 7
Study: NCT04722887

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Alpha-1 15%
Description: Alpha1-Proteinase Inhibitor (Human), 15%, Subcutaneous infusion

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Alpha-1 15%
Description: Alpha1-Proteinase Inhibitor (Human), 15%, Subcutaneous infusion

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Alpha-1 15%
Description: Alpha1-Proteinase Inhibitor (Human), 15%, Subcutaneous infusion

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Liquid Alpha1-Proteinase Inhibitor (Human)
Description: Intravenous infusion

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Liquid Alpha1-Proteinase Inhibitor (Human)
Description: Intravenous infusion
Study: NCT05254886

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: NEMO nurse-led program
Description: The NEMO nurse-led program will consist of a single nursing consultation conducted on the day of the inclusion visit during which the nurse will:~* Report the presence of pre-existing comorbidities/EIMs~* Detect the presence of risk factors~* Implement recommendations for the detection and/or management of comorbidities/EIMs.
Study: NCT05778019

Intervention type: OTHER
Intervention: Case Scenarios of complications to be ranked / classified according to classifications (for the severity grading of events)
Description: Test the feasibility, applicability and logic of a novel instrument for the grading of unexpected events in pediatric surgery (Clavien-Madadi classification) compared to the Clavien-Dindo classification for the grading of postoperative complications in general surgery
Study: NCT03423511

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MiStent II coronary artery stent
Description: Implantation of a coronary stent patient with stable and unstable coronary artery disease including non-ST-Elevated Myocardial Infarction

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Xience or Promus coronary artery stents
Description: Implantation of a coronary stent patient with stable and unstable coronary artery disease including non-ST-Elevated Myocardial Infarction
Study: NCT04635137

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ablation and Cementoplasty
Description: Percutaneous thermal ablation with subsequent cementoplasty in a single procedure
Study: NCT04841720

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HSK16149
Description: HSK16149 capsules for single use: D1-D4 oral HSK16149 capsules 80 mg BID, D5 only oral HSK16149 capsules 80 mg in the morning on an empty stomach; wash-out period is about 4 days (D5-D8);

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin Hydrochloride tablet
Description: Metformin hydrochloride tablets for single use: D9-D11 oral metformin hydrochloride tablets 500 mg BID, D12 only take 500 mg metformin hydrochloride tablets in the morning on an empty stomach; wash-out period is about 4 days (D12-D15);

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HSK16149+Metformin（phase 3）
Description: Combined use of HSK16149 capsules and metformin hydrochloride tablets: D16-D19 oral metformin hydrochloride tablets 500 mg BID, D16-D19 oral HSK16149 80 mg BID; D20 oral metformin hydrochloride tablets 500 mg and HSK16149 capsules 80 mg in the morning on an empty stomach.