TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06633601

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MR-Guided Focused Ultrasound Technology
Description: MRI Guidance for use with High-intensity-focused ultrasound (HIFUS)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Definity Suspension for Injection
Description: Microbubble contrast agents for ultrasound
Study: NCT06633874

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: TD Playing the Serious Game APSOU
Description: After parents participate in informative meetings, they proceed with written consent, SmartSpeech enrollment, and child developmental history. Then, the child may interact with the Serious Game. Typically developed (TD) children engage under the clinician's face-to-face supervision with the serious game APSOU, which assesses developmental domains, including speech, language, psychomotor, cognitive, psychoemotional, and hearing abilities. The average time for TD children to play the whole game is estimated to be 45 minutes.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Non-TD Playing Serious Game
Description: After parents participate in informative meetings, they proceed with written consent, SmartSpeech enrollment, and child developmental history. Then the child may interact with the serious game. Non-typically developed (non-TD) children engage under the clinician's face-to-face supervision with the serious game Apsou, which assesses developmental domains, including speech, language, psychomotor, cognitive, psychoemotional, and hearing abilities. The average time for non-TD children to play the whole game is estimated to be over an hour.
Study: NCT06633705

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vaginal Cream with Applicator
Description: Vaginal Cream that contains estriol (1mg estriol in 1 g cream)
Study: NCT04667286

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Prone Position (PP)
Description: Prone the patients on oxygen for at least 10 hrs a day

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Prone Position (PP)
Description: Prone the patients on oxygen for at least 10 hrs a day
Study: NCT04794036

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Asynchronous telerehabilitation programme
Description: Home-based physical rehabilitation programme using a telerehabilitation platform

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Rehabilitation programme
Description: Home-based physical rehabilitation programme by means of an explanatory booklet
Study: NCT05178498

Intervention type: PROCEDURE
Intervention: Follow-Up
Description: Undergo follow up

Intervention type: PROCEDURE
Intervention: Physical Examination
Description: Complete physical measurements

Intervention type: OTHER
Intervention: Questionnaire Administration
Description: Complete questionnaires
Study: NCT05686096

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MYK-224
Description: Specified dose on specified days
Study: NCT06054087

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Basal therapy+EA
Description: 1. Participants are not set up with uniform medication. High blood sugar is controlled by hypoglycaemic drugs, patients with hypertension and hyperlipidaemia can take antihypertensive and lipid-lowering drugs, while other drugs are based on the patient's current medication.~2. Main acupoints: Qihai (RN6), Guanyuan (RN4), Xuehai (SP10), Yanglingquan (GB34), Zusanli (T36), Yinlingquan (SP9), Sanyinjiao (SP6), Xuanzhong (GB39), Jiexi (ST41), Zulinqi (GB41), Taichong (SP41). Supporting acupoints: for pain in the upper limbs, add Baxie, Quchi (LI11), Shousanli (LI10), Hegu (LI4), and Ashixue; for pain in the lower limbs, add Bafeng, Neiting (ST44),Kunlun (BL60). Operation: Acupuncture needles of size 25\*40mm will be used. The electrode will be connected Yanglingquan (GB34) and Sanyinjiao (SP6), electrode wire will be connected to the electro-acupuncture apparatus using continuous wave with a frequency of 2Hz at an intensity suitable for the comfort of the subject.
Study: NCT04682925

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: skin care arm of where evidence-based practices in the implementation guide
Description: 1. The nasal mucosa and nasal skin under the nasogastric tube will be cleaned and dried twice a day with a pH-compatible cleanser.~2. A water-based moisturizing cream will be applied to the nasal skin under the nasogastric tube twice a day, after care with a pH-compatible cleanser.~3. Spray skin barrier will be applied twice a day after applying water-based moisturizing cream to the nasal skin under the nasogastric tube.~4. The nasal mucosa and nasal skin under the nasogastric tube will be evaluated twice daily for signs of pressure-related injury. All these care interventions applied to the skin care arm will be applied together with the doctor and nurse responsible for the treatment and care of the patient.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: hydrocolloid (Convatec Granuflex-extra thin) dressing
Description: The nasal skin of the patients and the surrounding skin will be cleaned with a pH-compatible cleaner, dried and a new hydrocolloid cover will be applied once a day. All these care interventions applied to the hydrocolloid dressing arm will be applied together with the physician and nurse responsible for the treatment and care of the patient.

Intervention type: OTHER
Group type: OTHER
Intervention: control
Description: In routine care, the skin under the nasogastric tube is evaluated once a day for redness and wound formation by the nurse responsible for the patient's care and is cleaned and dried with appropriate cleaners.
Study: NCT04873973

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Telemedical support
Description: The nursing homes participating in the project will be equipped with telemedical equipment. This will allow teleconsultations to take place when needed. In addition, an early warning system will be introduced and, within the framework of the teleconsultation, a trained medical assistant can be sent to the care facility if necessary, who can carry out medical activities on site under a physician's delegated instructions. In addition, an electronic patient file will be introduced which can be accessed by the telemedicine physician and the general practitioner.
Study: NCT05184881

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Retrolaminar block
Description: 2- Cervical retrolaminar block: will be performed on prone-positioned patients. Under fluoroscopic visualization, after identification of the lamina at the desired level, a 25-gauge, 3.5-inch spinal needle was introduced and when the needle tip will be confirmed at the posterior aspect of the cervical lamina corresponding to cervical facet arthropathy level. 5 mL of a mixture of 3 mL 1% lidocaine and 2 mL dexamethasome (8mg/2ml) will be injected.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Medial Branch Block
Description: 1- Cervical medial branch block: will be performed on prone-positioned patients using a posterior approach. Under fluoroscopic visualization, after identification of the waists of the articular pillars at the desired levels, each medial branch block was administered with a 25-gauge, 3.5-inch spinal needle. When the place of the needle tip will be confirmed at the mid-point of the waists of articular pillars, 1 ml of the mixture of 0.5 mL 1% lidocaine and 0.5 mL dexamethasome (8mg/2ml) will be injected at each level.
Study: NCT06054087

Intervention type: OTHER
Group type: OTHER
Intervention: Basal therapy
Description: Participants are not set up with uniform medication. High blood sugar is controlled by hypoglycaemic drugs, patients with hypertension and hyperlipidaemia can take antihypertensive and lipid-lowering drugs, while other drugs are based on the patient's current medication.
Study: NCT05668546

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: isokinetic testing CSMI HUMAC NORM instrument
Description: The strength (PT) of the bilateral knee flexors and extensors were tested with isokinetic test. Tests were performed under the guidance of a rehabilitation medicine specialist, and the system was calibrated prior to their commencement. The patients were seated in upright position and were fixed with pelvic and thigh belts. Concentric extension (PT_E) and concentric flexion (PT_F) were measured between the 0° and 90° knee ranges at angular velocities of 60°/s and 180°/s (60 PT_E, 60 PT_F, 180 PT_E, and 180 PT_F, respectively) The tests were repeated five times at each velocity, and the highest PTs were selected for statistical analysis. The participants performed repeated trials before sets, while a 20-second rest was provided between sets.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: isokinetic testing CSMI HUMAC NORM instrument
Description: The strength (PT) of the bilateral knee flexors and extensors were tested with isokinetic test. Tests were performed under the guidance of a rehabilitation medicine specialist, and the system was calibrated prior to their commencement. The patients were seated in upright position and were fixed with pelvic and thigh belts. Concentric extension (PT_E) and concentric flexion (PT_F) were measured between the 0° and 90° knee ranges at angular velocities of 60°/s and 180°/s (60 PT_E, 60 PT_F, 180 PT_E, and 180 PT_F, respectively) The tests were repeated five times at each velocity, and the highest PTs were selected for statistical analysis. The participants performed repeated trials before sets, while a 20-second rest was provided between sets.
Study: NCT05473143

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Protocol-based fluid management
Description: Fluid removal will be prescribed using a standardized template updated at least once per working day, before noon of each day, by the attending care team. This protocolized prescription will contain three components. Fluid removal will be prescribed using a standardized template updated at least once per working day, before noon of each day, by the attending care team. This protocolized prescription will contain three components.~The first component of this prescription will be to define the 24h-fluid balance target either aiming for a negative fluid balance of 2 to 3% body weight (1.4-2.1 liters in a 70 Kg participant) (Option 1) or by aiming to avoid fluid accumulation by targeting a neutral fluid balance within 0.5% of body weight variation (-350 to +350 mL in a 70 Kg participant) (Option 2).~The second component is to pre-specify a prescription for fluid removal using KRT.~The third component is to prompt a daily re-evaluation of fluid intake by the attending care team.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual care
Description: The net fluid removal and the rate of net fluid removal will not be protocolized and will be prescribed and adjusted according to the attending care team without any specific guidance. The use of the documents provided for the intervention group will not be permitted in the control arm.
Study: NCT05180214

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacain
Description: analgesic

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacain
Description: analgesic

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ketorolac
Description: analgesia
Study: NCT06144346

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Ablative Radiation Therapy
Description: SABR to all metastatic lesions

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Locoregional treatment
Description: mastectomy or BCS for the primary tumor

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard of Care
Description: Systemic treatment and palliative treatment
Study: NCT06187610

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital education
Description: Patients assigned to the experimental group will learn about symptom self-management in a digital learning environment.
Study: NCT05302141

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Wear 3D printing assistive device
Description: Wear 3D printing aids and engage in functional tasks, including eating, typing, and writing.~At home: use daily, 30 minutes each time; Treatment room: 30 minutes twice a week

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Wear universal cuff device
Description: Wear universal cuff aids and engage in functional tasks, including eating, typing, and writing.~At home: use daily, 30 minutes each time; Treatment room: 30 minutes twice a week
Study: NCT05644795

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Wheat/milk free diet (W/MFD) group
Description: Patients randomized to intervention diet group will have to follow a wheat and cow's milk products free diet and, after 2 months, they will be exposed to an open wheat challenge, with reintroduction of wheat. After 2 weeks of open diet, or whenever dermatologic, intestinal and/or extraintestinal symptoms should return or intensify, all patients will be revaluated and will end the study.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Rice/turkey free diet (R/TFD) group
Description: Patients randomized to control diet group will have to follow a diet with elimination of rice and turkey's meat products for 2 months; after that they will crossover to a wheat and cow's milk products free diet and, finally, after 2 months, they will be exposed to an open wheat challenge, with reintroduction of wheat. After 2 weeks of open diet, or whenever dermatologic, intestinal and/or extraintestinal symptoms should return or intensify, all patients will be revaluated and will end the study.
Study: NCT06286826

Intervention type: PROCEDURE
Intervention: Postero-lateral thoracotomy
Description: this incision extends from the anterior axillary line, goes posteriorly behind the scapula and includes the division of the fibres of the latissimus dorsi muscle and the serratus anterior muscle. The latter approach presents the risk of numerous long-term musculoskeletal complications such as costal abnormalities (costal hypoplasia, costal fusion), winged scapula, scoliotic spine posture

Intervention type: PROCEDURE
Intervention: Minithoracotomy
Description: Minithoracotomy aims to preserve the muscles of the rib cage by retracting or disconnecting them rather than sectioning them (muscle sparing technique)
Study: NCT05996029

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Digital Smoking Cessation
Description: The core technology of the study is a smoking cessation assistance practice service driven by a machine learning algorithm. The small programs used by the intervention group in this study included smoking cessation service packages based on cognitive behavioral therapy and online guidance from medical staff on staff, and more digital smoking cessation tools.
Study: NCT06507397

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: hyperbaric bupivacaine and fentanyl
Description: Patients received 3ml hyperbaric bupivacaine 0.5% combined with 25 microg of fentanyl.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: plain bupivacaine and fentanyl
Description: Patients received 15 mL mixture of (0.25% plain bupivacaine and 50 µg fentanyl) over 5 minutes, injected in the epidural space by epidural catheter at L3-L4 interspace, a dural puncture was created by the spinal needle. Braun's Espocan® combined spinal epidural kit before insertion of epidural catheter (needle-through-needle technique) but intrathecal medication administration was withheld.
Study: NCT06301750

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Conventional Care
Description: Basic treatment, including corresponding control of risk factors and education on healthy lifestyles.~Swallowing training, including lemon ice stimulation, mendelson maneuver, empty swallowing training, and pronunciation training.~Pulmonary function training, including standing training, cough training, and diaphragm muscle training.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Care
Description: Basic treatment, including corresponding control of risk factors and education on healthy lifestyles.~Swallowing training, including lemon ice stimulation, mendelson maneuver, empty swallowing training, and pronunciation training.~Pulmonary function training, including standing training, cough training, and diaphragm muscle training.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Intermittent Oral-esophageal Tube Feeding
Description: Before each feeding, inside and outside of the tube was cleaned with water. During feeding, the patient should maintain a semi-reclining or sitting position with mouth opened, and the tube was inserted slowly and smoothly into the upper part of the esophagus by medical staffs while the appropriate depth of intubation was checked with the calibration markings on the tube wall. The distance from the incisors to the head part of the tube should be between 22-25 cm. However, the specific depth should be evaluated based on patients' feedback and adjusted accordingly. After insertion, the tail part of the tube should be put into a container full of water and the absence of continuous bubbles indicated a successful intubation. Then, the feeding was to be conducted three times per day with 50 ml per minute and 400-600ml for each feeding.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Nasogastric tube
Description: Within 4 hours after admission, the placement of the feeding tube was conducted by professional medical staffs and after intubation, the tube was secured to the patient's cheek with medical tape. The feeding was conducted once every 3-4 hours, with 200-300ml each time. The total feeding volume was determined based on daily requirements. The feeding content was formulated by the nutritionists based on the patient's condition and relevant guidelines to reach the energy demand as 20-25 kcal/kg/day and protein supplementation of 1.2-2.0 g/kg/day for both two groups. For patients with limited tube feeding compliance, we made appropriate adjustments to ensure that they were not at risk of severe malnutrition as much as possible.
Study: NCT04928209

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Speech-Language Teletherapy
Description: Access to speech-language teletherapy will be provided as a supplement to Usual Care for subjects randomized to this group. Access is provided by way of 1) direct referral by the clinical team to a teletherapist; 2) availability of a teletherapy slot. All teletherapy providers will be licensed speech-language pathologists (SLPs) and/or credentialed teachers of the deaf (TODs) with specialized training to work with children who are D/HH using an LSL approach. Fluent English and Spanish speaking providers will be matched to the child's home, native language. Teletherapy itself is within routine clinical care and is not considered a research activity. Children who randomize to the Low TT study arm will receive access to an 18-month course of weekly teletherapy, in accordance with the centers' standard of care. The exact details of the therapy course and frequency will be determined based on individual family needs.
Study: NCT05176873

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DZD8586
Description: Single dose of DZD8586. Starting dose of DZD8586 is 20mg. If tolerated, subsequent cohorts will test increasing doses of DZD8586.
Study: NCT04941456

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Open Tracheostomy
Description: Participants will perform the six minute walk test with an open tracheostomy. Participants will complete 1 to 3 session over approximately three-weeks.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: PMV in place
Description: Participants will perform the six minute walk test with a PMV in place. Participants will complete 1 to 3 sessions over approximately three-weeks.
Study: NCT05334420

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Healthy Dads Healthy Kids
Description: Group based lifestyle behavioral intervention for weight loss for fathers and increased physical activity for their child. The program meets weekly 90-minute sessions over 10 weeks. Mothers/partners are invited to one session (Week 4). Each meeting consisted of a brief review session with Dads and Kids together (15 minutes), separate break-out discussion for Dads (Dad's Club) and Kids (Kid's Club) (30 minutes); and a joint physical activity component for Dads and Kids (Sports Club) (45 minutes). Each week covers different topics for fathers and a corresponding session for kids. The program encourages fathers to be healthy, positive role models for their children, and teaching fathers weight loss strategies, authoritative parenting strategies and to encourage healthy behaviors in their kids. Fathers and kids are encouraged to eat healthy, reduce their screen time and be more active. If the COVID pandemic prevents in-person meetings, the program will be delivered virtually.

Intervention type: OTHER
Group type: OTHER
Intervention: Standard of care control
Description: Families will receive handouts on healthy eating, physical activity and screen media use to promote healthy weight status. Fathers will attend one group session with a focus on dietary changes and increased physical activity to promote healthy weight loss.
Study: NCT05847075

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Heat Therapy
Description: Participants in the HT group will undertake whole body heat treatment according to previous methods. Participants will be housed in an environmental chamber initially set at 55.0oC on three non-consecutive days of the week during 12 weeks. Each session will last 60 min.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: StrengthTraining
Description: Participants will perform supervised exercise in a gym on three non-consecutive days of the week. Each session will last \~60 min and will consist of a warm up, the resistance training and a cool down. All sessions will be conducted by qualified sport and exercise scientists for 12 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sedentary Control
Description: Participants will not receive any intervention during 12 weeks.
Study: NCT06229496

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Gemcitabine 800mg/m2 + Nab-paclitaxel 100mg/m2 + S-1 (dose according to BSA)
Description: Dose escalation study-dose level 1

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Gemcitabine 800mg/m2 + Nab-paclitaxel 125mg/m2 + S-1 (dose according to BSA)
Description: Dose escalation study-dose level 2

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Gemcitabine 1000mg/m2 + Nab-paclitaxel 125mg/m2 + S-1 (dose according to BSA)
Description: Dose escalation study-dose level 3
Study: NCT06358404

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: PeersCOG
Description: . The intervention will consist of 8 weekly video chats focused on emotional, appraisal, and informational support delivered by community-based older adult peer coaches to adults 60 years of age and older with subthreshold depression and SCD.
Study: NCT06048627

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Amine/zinc lactate/fluoride system
Description: Amine/zinc lactate/fluoride system (250 ppm F), meridol®, Colgate-Palmolive

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: negative control
Description: Sodium fluoride mouthwash 250 ppm