TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05257837

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Gun handling behavior
Description: Children will play in an observed room for 20 minutes. Aside from a selection of toys, two real handguns will be placed in a drawer. The handguns have been modified so they cannot fire. Inside the magazine, the handgun contains no bullets. Instead, it contains a sensor that counts the number of times the trigger is pulled with sufficient force to discharge the gun. This allows us to distinguish reliably the children who pull the trigger from those who handle the gun but do not pull the trigger

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Debriefing
Description: Children and their parents will be debriefed on the actual purpose of the study, including the role of the safety video and how the movie clips were edited.
Study: NCT06675149

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Diacutaneus fibrolysis
Description: Material : Stainless steel large angle and small long angle: length 22cm x height 6cm x width 2cm. Weight: 70 grams

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Transcutaneus electrical nerve stimulation
Description: physical therapy electrical modality

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneus electrical nerve stimulation
Description: physical therapy electrical modality

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Massage
Description: manual therapy intervention

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Massage
Description: manual therapy intervention
Study: NCT06674343

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Furmonertinib
Description: Furmonertinib 160mg, once daily, orally. Other Names: AST2818
Study: NCT06028347

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: sa-mRNA vaccine Dose 2
Description: self-amplifying mRNA vaccine

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: sa-mRNA vaccine Dose 3
Description: self-amplifying mRNA vaccine

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Saline for injection
Study: NCT06466382

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treatment recommendation by molecular tumorboard (mTB) based on tumor profiling
Description: The intervention studied is a treatment recommendation by a specialized molecular tumorboard (mTB). This recommendation is based on an MSR which is created by TP, i.e., molecular analysis of clinical specimens, obtained from the individual participant. TP, a technology platform of several precision-cancer profiling domains, combines and rates the most efficient drugs/ experimental treatments for an individual ovarian cancer patient independent of standard of care. The usability in clinical practice of this recommendation will be tested. It should support the clinical decision of the treating oncologists and patients to choose the best possible therapy for the individual patient.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carboplatin / Paclitaxel Chemotherapy
Description: 2 cycles of chemotherapy with carboplatin AUC5 3-weekly and paclitaxel 175 mg/m2 3-weekly or carboplatin AUC2 weekly and Paclitaxel 60-80mg/m2 weekly
Study: NCT06582264

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MB310
Description: Live bacterial therapeutic for oral administration

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: MB310-matching placebo for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vancomycin
Description: Antibiotic

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Vancomycin
Description: Antibiotic
Study: NCT05154487

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Alpelisib Pill
Description: Kinase inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fulvestrant injection
Description: estrogen receptor agonist
Study: NCT06536608

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Massage
Description: The Oketani Method is based upon practical breastfeeding theory, but is original in its practice. Oketani breast massage improves breastmilk secretion, can prevent and treat problems such as mastitis. In addition, the massage is painless, allowing your body to relax and breathe, something very much appreciated by mothers.~The Oketani breast massage consists of massaging and milking the base of the breasts. These delicate glands are massaged as well as protected.
Study: NCT05257837

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Debriefing
Description: Children and their parents will be debriefed on the actual purpose of the study, including the role of the safety video and how the movie clips were edited.
Study: NCT05171075

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Abelacimab
Description: Abelacimab 150 mg

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dalteparin
Description: Dalteparin 200 IU/kg/day followed by 150 IU/kg/day
Study: NCT05257837

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Debriefing
Description: Children and their parents will be debriefed on the actual purpose of the study, including the role of the safety video and how the movie clips were edited.
Study: NCT06673784

Intervention type: DIAGNOSTIC_TEST
Intervention: ophthalmic saline eye drops
Description: for optical examination

Intervention type: DRUG
Intervention: Saline
Description: Most one natural and not effects on study
Study: NCT06673459

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TBICy
Description: The TBI-Cy group was administered 250 mg/m2/d oral Me-CCNU on day -8. A total of 12 Gy TBI was for each patient and fractionated dose was 2 Gy twice daily or 4Gy once daily on days -8 to -6. Occluding of the lung fields during TBI, the corresponding irradiation dose reduced to a total of 8 Gy. On day -5, the schedule was intravenous 2 g/m2 Ara-C every 12 hours. Then intravenous 1.8 g/m2 CTX once per day from days -4 to -3.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: BuCy
Description: The BuCy group received oral Me-CCNU 250 mg/m2/d twice daily on day -8, intravenous cytosine arabinoside (Ara-C) 2 g/m2 twice daily on day -7, intravenous Bu 3.2 mg/kg/d from days -6 to -4, and intravenous cyclophosphamide (CTX) 1.8 g/m2/d from days -3 to -2. There were no patients accepted oral Bu.
Study: NCT06674460

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sublingual edaravone dexborneol
Description: One tablet of Edaravone Dexborneol Sublingual Tablet (containing 30mg Edaravone and 6mg Dexborneol) to be taken sublingually, twice daily.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: One placebo tablet, to be taken sublingually, twice daily
Study: NCT06684652

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: 3TB+6SB
Description: The biopsy procedure was conducted by a highly skilled and experienced urologist who specializes in performing prostate biopsies. Prophylactic antibiotics were routinely used both before and one day prior to scheduled surgery. Each patient was placed in the left lateral position or lithotomy position. The ultrasound equipment used included a color Doppler ultrasound diagnostic instrument (Hitachi HiVision, Philips Epiq 7), transrectal probes, and corresponding puncture needle guns. Color Doppler examination was performed from the base to the apex. For each predefined mpMRI suspicious lesion, urologists firstly obtained three-core TB from the lesion within the mpMRI suspicious lesion. Then urologists obtained sextant six-core SB. Each core was placed in an individual container and reported separately in accordance with the Ginsburg scheme. Histology was evaluated by senior uropathologists who were blinded to the imaging findings.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: 3TB+12SB
Description: The biopsy procedure was conducted by a highly skilled and experienced urologist who specializes in performing prostate biopsies. Prophylactic antibiotics were routinely used both before and one day prior to scheduled surgery. Each patient was placed in the left lateral position or lithotomy position. The ultrasound equipment used included a color Doppler ultrasound diagnostic instrument (Hitachi HiVision, Philips Epiq 7), transrectal probes, and corresponding puncture needle guns. Color Doppler examination was performed from the base to the apex. Urologists firstly obtained three-core TB from the lesion within the mpMRI suspicious lesion. Then urologists obtained fore-zone 12-core SB. Each core was placed in an individual container and reported separately in accordance with the Ginsburg scheme. Histology was evaluated by senior uropathologists who were blinded to the imaging findings.
Study: NCT06690879

Intervention type: DEVICE
Intervention: Smartphone application AI Posture Evaluation and Correction System (APECS)
Description: Mobile application APECS v. 6.2.0. is used to assess upper body posture during standing from back side and right side.

Intervention type: DEVICE
Intervention: Smartphone application AI Posture Evaluation and Correction System (APECS)
Description: Mobile application APECS v. 6.2.0. is used to assess upper body posture during standing from back side and right side.
Study: NCT06690320

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: IMPLEMENTATION OF A PLANNED EDUCATION PROGRAM ON HEALTH BELIEF MODEL AND FATUALIST TENDENCIES IN WOMEN AT HIGH RISK OF BREAST CANCER
Description: Description: By examining the parameters of the health belief model and fatalism scales, 6 targets were determined for these scale parameters. The targets were prepared to gain early diagnosis behaviors in breast cancer. By using the breast model, the behavior will be demonstrated in practice
Study: NCT06691828

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NX-5948
Description: NX-5948 will be given once by IV and then given once by mouth.
Study: NCT06688864

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: EPIO App
Description: Participants will receive access to the app-based cognitive-behavioral pain self-management intervention program (EPIO) for 3 months.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: EPIO App
Description: Participants will receive access to the app-based cognitive-behavioral pain self-management intervention program (EPIO) for 3 months.
Study: NCT06691594

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: neoadjuvant SBRT combined with PD-1 monoclonal antibody and chemotherapy
Description: Eligible participants will receive neoadjuvant treatment consisting of:~SBRT: One session of 10Gy radiation to the primary tumor, followed by a 150mg subcutaneous injection of pembrolizumab (PD-1 inhibitor).~Chemotherapy and Immunotherapy: One week after SBRT, participants will undergo 6 cycles of pembrolizumab (400mg), albumin-bound paclitaxel (250mg/m²), and carboplatin (AUC=5).~Surgery: Surgery will be performed 21 days after the last chemotherapy cycle, with either breast-conserving surgery or modified radical mastectomy. Pathological evaluation will assess the treatment response.~Adjuvant Immunotherapy: Four weeks post-surgery, patients will receive pembrolizumab every 3 weeks for up to 1 year.
Study: NCT06691542

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: platelet-rich plasma
Description: platelet-rich plasma, metformin and cryotherapy in treatment of non-genital warts

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: platelet-rich plasma, metformin and cryotherapy in treatment of non-genital warts

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: cryotherapy
Description: platelet-rich plasma, metformin and cryotherapy in treatment of non-genital warts
Study: NCT06688461

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental group: Exercise training
Description: HIIT program, 3 times per week for 12 weeks
Study: NCT05520736

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Appointment reminders, motivational interviewing and targeted vaccine drives
Description: Automated and real time phone call reminders, motivational interviewing and targeted vaccine drives applied in sequence
Study: NCT06693947

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alpine dairy products
Description: The intervention group will be instructed to eat three portions of alpine dairy products daily. The proposed three portions represent an estimated mean consummation in the study population, taking into consideration the national statistics.
Study: NCT06004167

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Adaptive Bridging Radiation Therapy (ABRT)
Description: Radiation Therapy
Study: NCT05476822

Intervention type: DIAGNOSTIC_TEST
Intervention: Obtain antibody titers
Description: Obtain blood samples for antibody titers at the time of enrollment, at three months, six months and nine months post vaccine booster (+/- ten days).
Study: NCT06695663

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Referral and communication skills learning
Description: assigned to receive a brief, live, experiential training on the referral process and communication strategies.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Written guide to the referral process
Description: assigned to receive only written information about the referral process

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Empowered Generations (eGen): parent training
Description: eGen is a six-session parent training program provided by therapists via video chat online to parents with a child between the ages of 3-8 years.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: control
Description: The control condition consists of a single scripted session, in which therapists guide the parent to the following resources: (a) a book, Raising Cooperative Kids, by GenPMTO co-developer Marion Forgatch; (b) vetted parenting advice websites; (c) information about Early Childhood and Family Education classes, which are provided for free in Minnesota through public schools; and (d) a list of culturally tailored parenting advice websites.
Study: NCT06687421

Intervention type: OTHER
Intervention: High-risk treatment SOC
Description: radiotherapy (RT) + ADT (3 years) + Abiraterone acetate (2 years), with radical prostatectomy being an option if contraindication for RT exists)
Study: NCT04976023

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Yupingfeng Powder granules
Description: 14.5 5 g twice daily for 8 weeks
Study: NCT06687421

Intervention type: OTHER
Intervention: Active monitoring
Description: Followed with PSA measurements
Study: NCT05008185

Intervention type: PROCEDURE
Intervention: Regenerative Peripheral Nerve Interface (RPNI) surgery
Description: Surgeons will perform neuroma resection and RPNI creation using a free muscle graft from the brachioradialis muscle harvested through a small separate incision

Intervention type: PROCEDURE
Intervention: Traction Neurectomy
Description: Surgeons will perform neuroma resection and traction neurectomy,
Study: NCT06187662

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Checklist
Description: This intervention consists of a checklist to guide blood culture decisions, that a clinician in a site randomized to Arm A will be asked to consult and complete prior to ordering or not ordering a blood culture; as the relevant clinical scenario occurs. Meaning, if a clinician in Arm A is faced with a scenario in which it is customary or usual care to consider a blood culture, the clinician will be asked to first review this checklist. The checklist is not a binding or absolute process - the clinician should use both the checklist and typical clinical judgment to decide if the blood culture test is needed or not. The checklist is based on prototypes used in the completed parent study, BrighT STAR and the earlier preliminary studies at Johns Hopkins.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Checklist
Description: This intervention consists of a checklist to guide blood culture decisions, that a clinician in a site randomized to Arm A will be asked to consult and complete prior to ordering or not ordering a blood culture; as the relevant clinical scenario occurs. Meaning, if a clinician in Arm A is faced with a scenario in which it is customary or usual care to consider a blood culture, the clinician will be asked to first review this checklist. The checklist is not a binding or absolute process - the clinician should use both the checklist and typical clinical judgment to decide if the blood culture test is needed or not. The checklist is based on prototypes used in the completed parent study, BrighT STAR and the earlier preliminary studies at Johns Hopkins.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Targeted Messaging
Description: This intervention consists of targeted messaging and education that the primary study team will create and ask the Arm B sites to deliver to the PICU clinicians, which focuses on the importance of diagnostic stewardship and the current evidence for the benefit/low risk nature of the stewardship program to date.
Study: NCT06025747

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Abemaciclib
Description: Given PO
Study: NCT06687421

Intervention type: PROCEDURE
Intervention: Radical prostatectomy
Description: Radical prostatectomy

Intervention type: RADIATION
Intervention: Radiotherapy
Description: Radiotherapy

Intervention type: DRUG
Intervention: Androgen deprivation therapy
Description: GnRH agonist + abiraterone acetate/enzalutamide and/or docetaxel
Study: NCT05168371

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive-Behavioural Therapy - Online (CBT-O)
Description: Face-to-face CBT was adapted for web-based self-directed therapy. CBT-O was found to be feasible and usable (Stephenson et al., 2021; Zippan et al., 2020).~Each of the eight modules has between-module activities to complete. The eight modules are: 1) Psychoeducation, introduction to CBT; 2) The cognitive model and thought records; 3) Unhelpful thinking patterns; 4) Cognitive restructuring; 5) Behavioral experiments; 6) Self-touch and sensate focus; 7) Sensate focus with your partner; and 8) Maintaining (and extending) your gains.
Study: NCT06691555

Intervention type: DEVICE
Intervention: Suprachoroidal silicone tube (SST) shunt
Description: This intervention involves implanting a modified suprachoroidal silicone tube (SST) shunt, derived from the Aurolab Aqueous Drainage Device (AADI), to lower intraocular pressure in patients with primary open-angle and pseudoexfoliative glaucoma. The SST shunt, measuring 13.0-15.0 mm with a 0.3 mm inner and 0.6 mm outer diameter, is designed to reach the posterior suprachoroidal space. Six slits near the distal end aid aqueous outflow. Implantation involves creating a scleral flap, accessing the SCS, and placing the distal end in the SCS and proximal end in the anterior chamber (AC). The shunt is secured with sutures, and viscoelastic is injected into the AC to prevent hypotony. No antimetabolites or cautery are used.
Study: NCT06686108

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azacitidine (AZA) Days 1 - 5
Description: Azacitidine, ih, 32mg/m2/d, days 1-5 of each 28-day cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Decitabine (DAC)
Description: decitabine, 5mg/m2/d, days 1-5 of each 28-day cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: venetoclax, 400mg/d, days 1-7 of each 28-day cycle
Study: NCT06686121

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Home Based Exercise
Description: This is a six month intervention where participants will walk at home for exercise with guidance from a study coach. They will attend two to four weekly meetings with the coach at the clinical site in the first 4 weeks following randomization, followed by once weekly telephone coaching calls for the remainder of the six-month intervention
Study: NCT06025747

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Radiation Therapy
Description: Undergo radiation therapy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Therapeutic Surgical Procedure
Description: Undergo surgery
Study: NCT05708352

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Keto Diet
Description: The experimental intervention includes a strict and controlled diet that manages daily macronutrient breakdown and increases the ratio of dietary fat relative to protein and carbohydrate consumption.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Standard Anti-Cancer Diet
Description: Dietitian sessions will utilize the American Institute for Cancer Research Food resources and will reference foods low in fats such as fruits, vegetables and whole grains, providing key micronutrients and phytonutrients. Sessions will also focus on dietary support to help decrease any treatment related symptoms.
Study: NCT06441864

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy for Nightmares
Description: The intervention will consist of 7 therapy sessions (once per week for 7 weeks) which will be delivered via videoconference. Partners will attend 2 of the 7 treatment sessions. During the sessions, participants will learn techniques for managing and changing nightmares.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy for Nightmares
Description: The intervention will consist of 7 therapy sessions (once per week for 7 weeks) which will be delivered via videoconference. Partners will attend 2 of the 7 treatment sessions. During the sessions, participants will learn techniques for managing and changing nightmares.
Study: NCT04572763

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Copanlisib
Description: Intravenous infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Copanlisib
Description: Intravenous infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Tablet taken orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Tablet taken orally
Study: NCT06468605

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: JCXH-211
Description: JCXH-211 is a lipid nanoparticle (LNP) encapsulated srRNA, encoding the human IL-12 protein.
Study: NCT05168371

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-Based Therapy - Online (MBT-O)
Description: The content of MBT-O was adapted from an efficacious face-to-face mindfulness intervention for women with Sexual Interest/Arousal Disorder (Brotto et al., 2021; Paterson et al., 2017). MBT-O was found to be feasible and usable (Brotto et al., under review).~Each of the eight modules has between-module activities to complete. The eight modules are: 1) Psychoeducation, introduction to mindfulness; 2) Increasing awareness of physical sensations in the body; 3) Exploring movement and body image; 4) Awareness of sexual thoughts and beliefs; 5) Working with aversion, self-touch; 6) Exploring sexual sensations, knowing limits; 7) Integrating the partner into mindful touching; and 8) Maintaining (and extending) your gains.