TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05635604

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Eptinezumab
Description: Eptinezumab or ALD403 is a humanized anti-calcitonin gene-related peptide IgG1 monoclonal antibody that binds to calcitonin gene-related peptide (CGRP). It selectively binds human CGRP ligand to prevent activation of the CGRP receptor and blocks its binding to the receptor for the prevention of migraine.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: PACAP-38
Description: PACAP-38 is a naturally occurring peptide diffusely expressed throughout the body. The Danish Headache Center has used infusion of PACAP-38 for several years and the first time in 2007 where infusion of PACAP-38 triggered headaches and migraines in migraine patients.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: PACAP-38
Description: PACAP-38 is a naturally occurring peptide diffusely expressed throughout the body. The Danish Headache Center has used infusion of PACAP-38 for several years and the first time in 2007 where infusion of PACAP-38 triggered headaches and migraines in migraine patients.
Study: NCT04828642

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Vitamin C and vitamin E
Description: 1000 mg 235 mg

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT05815342

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Omnipod 5 Automated Glucose Control System
Description: The Omnipod Horizon™ Automated Glucose Control System will provide automated insulin delivery
Study: NCT04737031

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinician Nudge
Description: Investigators will use the Best Practice Alert functionality within the EMR as the conduit to the point of decision-making. Epic currently fires a BPA for each new patient presenting to ACC within the Medical Assistant check-in and vital sign workflow, requiring that medical assistants assess tobacco use status within the past 30 days and satisfy the alert with one of three possible answers. Upon opening the Epic Order tab at a patient's next visit after the screening encounter, clinicians will receive the implementation strategy, placed directly over the order interface. The clinician will be required to acknowledge or opt-out when presented with the order. Opting-out will require clinicians to acknowledge a reason for opt-out using a checklist or free text.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinician Nudge
Description: Investigators will use the Best Practice Alert functionality within the EMR as the conduit to the point of decision-making. Epic currently fires a BPA for each new patient presenting to ACC within the Medical Assistant check-in and vital sign workflow, requiring that medical assistants assess tobacco use status within the past 30 days and satisfy the alert with one of three possible answers. Upon opening the Epic Order tab at a patient's next visit after the screening encounter, clinicians will receive the implementation strategy, placed directly over the order interface. The clinician will be required to acknowledge or opt-out when presented with the order. Opting-out will require clinicians to acknowledge a reason for opt-out using a checklist or free text.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Patient Nudge
Description: Patients will receive a message sent through myPennMedicine following establishment of their smoking status (at the screening encounter). In all cases, the message will include information specific to the upcoming appointment with the oncology clinician.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Patient Nudge
Description: Patients will receive a message sent through myPennMedicine following establishment of their smoking status (at the screening encounter). In all cases, the message will include information specific to the upcoming appointment with the oncology clinician.
Study: NCT05752292

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tailored Risk Information (TRI)
Description: Interactive prompts to provide tailored information on risk factors for type 2 diabetes

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tailored Risk Information (TRI)
Description: Interactive prompts to provide tailored information on risk factors for type 2 diabetes

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tailored Risk Information (TRI)
Description: Interactive prompts to provide tailored information on risk factors for type 2 diabetes

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing
Study: NCT05557396

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Internal Tube Length Measurement Procedures for Nazogastric Tube
Description: Different Internal Tube Length Measurement Procedures will used for the correct placement of nasogastric tube.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Internal Tube Length Measurement Procedures for Nazogastric Tube
Description: Different Internal Tube Length Measurement Procedures will used for the correct placement of nasogastric tube.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Internal Tube Length Measurement Procedures for Nazogastric Tube
Description: Different Internal Tube Length Measurement Procedures will used for the correct placement of nasogastric tube.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Internal Tube Length Measurement Procedures for Nazogastric Tube
Description: Different Internal Tube Length Measurement Procedures will used for the correct placement of nasogastric tube.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Internal Tube Length Measurement Procedures for Nazogastric Tube
Description: Different Internal Tube Length Measurement Procedures will used for the correct placement of nasogastric tube.
Study: NCT05752292

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational Interviewing-based (MI)
Description: Interactive prompts based on principles of motivational interviewing

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges
Study: NCT05503446

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Peanut in common foods or supermarket-sourced cow's milk (CM)
Description: Participants will be given a set dose of peanut (e.g. peanut-containing cereal, whole peanuts) or cow's milk to take on a daily basis, as per protocol

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Peanut in common foods or supermarket-sourced cow's milk (CM)
Description: Participants will be given a set dose of peanut (e.g. peanut-containing cereal, whole peanuts) or cow's milk to take on a daily basis, as per protocol
Study: NCT05209880

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ED GOAL
Description: The emergency department clinician-led, behavioral intervention (ED GOAL) is designed to engage seriously ill yet clinically stable older adults in the emergency department to address their values and preferences towards end-of-life care with their outpatient clinicians. The intervention consists of an interview to discuss participants' values and preferences for end-of-life care. The participants will receive coaching on how to initiate/re-introduce discussions about end-of-life wishes with their loved ones and outpatient clinicians. The participants' outpatient clinicians will also receive a summary of what participants disclosed via email or mailed letter.
Study: NCT05571358

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Virtual Reality (Nature Trek)
Description: At the end of each session, participants will experience an immersive virtual landscape displayed by Nature Trek VR software (httpp://naturetreksvr.com/). First, participants will be placed in a sit down position and guided for their breathing control during 5 minutes (meditation Lotus option). After that, they will be encouraged to freely move around a relaxing virtual environment during 15 minutes taking special attention to soothing sounds of nature. The themes environment will be selected based on the preferences of the participants.~At the beginning of the study, advice is given on general care, in physical activity and issues concerning drug intake. Patients are advised to refrain from any other specific training during the intervention period. Any deviations from the adherence and practice of the VRi are recorded daily, noting any adverse incidents.
Study: NCT06296056

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Combi
Description: Biological immune cell therapy
Study: NCT04838925

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Mobile Neurofeedback App
Description: Neurofeedback intervention delivered via mobile app. Participants wear an EEG headset which is connected to a mobile app that delivers feedback about brainwave data indicating whether they are in a calm, relaxed state. Participants hear a lower/simple sound when they are below a target level and higher/richer sound when they approach or achieve their target.
Study: NCT05097053

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MVC-COV1901(3 Months)
Description: MVC-COV1901 vaccine after a 3-month Interval

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MVC-COV1901(6 Months)
Description: MVC-COV1901 vaccine after a 6-month Interval
Study: NCT06555926

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupressure
Description: The pregnant women will receive acupressure on the (Pc-6/Lung-7 )acupoints one minute for each point with 3 repetitions on both side( about 30minutes /session),2 times per week in addition to advices for 12 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: advices for relieving carpal tunnel syndrome
Description: The pregnant women will receive advices for 12 weeks as follows:~* Avoid heavy lifting.~* Avoid repetitive tasks.~* Sit on chairs with armrests and elevate affected hand on the armrest~* Avoid sleeping on the side of the affected hand.~* Keep the wrist in a neutral (straight) position.~* Avoid positions of full flexion and extension.~* Reduce general swelling by:~  * eating less salty food .~ * elevating legs when sitting .~ * wearing compression garments.~* Apply cold water over the wrist.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: advices for relieving carpal tunnel syndrome
Description: The pregnant women will receive advices for 12 weeks as follows:~* Avoid heavy lifting.~* Avoid repetitive tasks.~* Sit on chairs with armrests and elevate affected hand on the armrest~* Avoid sleeping on the side of the affected hand.~* Keep the wrist in a neutral (straight) position.~* Avoid positions of full flexion and extension.~* Reduce general swelling by:~  * eating less salty food .~ * elevating legs when sitting .~ * wearing compression garments.~* Apply cold water over the wrist.
Study: NCT06208982

Intervention type: DIAGNOSTIC_TEST
Intervention: Colonoscopy images and videos
Description: A CADx system in real-time characterization of colonic ulcer diseases was constructed using artificial intelligence to extract endoscopic features from the training set. Subsequently, the performance of the CADx system was preliminarily tested through the validation set.
Study: NCT05752292

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action planning (AP)
Description: Interactive prompts to problem solve challenges
Study: NCT06483516

Intervention type: PROCEDURE
Intervention: Open repair
Description: Open repair via median laparotomy or lumbotomy

Intervention type: PROCEDURE
Intervention: Endovascular repair
Description: EVAR if AAA simple F-BEVAR if Complex AAA
Study: NCT06032299

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Single Distal Femur Implant
Description: Single implant constructs will be either a retrograde intramedullary nail with interlocking screws or a single plate and screw construct.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Dual Distal Femur Implant
Description: Dual implant constructs will either be an intramedullary nail with an additional plate and screw construct or dual (two plates in any orientation) plate and screw construct.
Study: NCT05398276

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral Exposure For Introceptive Tolerance
Description: BE-FIT will consist of a 6-session one-on one program with a clinician that are approximately 45 minutes delivered, over the course of 3 weeks (twice/week). Sessions will coincide with scheduled cardiac rehabilitation sessions at RWJ Cardiac Rehabilitation Program. The elements of BE-FIT are (1) psychoeducation about avoidance/anxiety and values clarification and committed action for exercise and lifestyle PA; (2) graded, repeated exposure to bodily sensations and exercise to build tolerance of discomfort; (3) fading safety behaviors and elimination of exercise avoidance behaviors to promote tolerance of uncertainty and reduce catastrophizing; and (4) use of Fitbit activity tracker to facilitate physical activity monitoring and provide physical activity feedback and goal-setting.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Health Education Control
Description: HEC is a time-matched control intervention that will be administered on the same delivery schedule as BE-FIT. The intervention content includes: (1) educational information about health topics relevant to healthy aging, and (2) Use of the Fitbit activity watch for PA monitoring. The 6 topics introduced in the HEC include: nutrition, sleep, brain health, emotional health, living with chronic conditions, how to be a smart patient. The health information will be conveyed through lectures and handouts. The goal of sessions will be to provide education, particularly as it relates to healthy aging. Patients will be given the same Fitbit as in the BE-FIT but will not be given PA goals.
Study: NCT04739657

Intervention type: DEVICE
Intervention: Insight Lifetech IVUS System
Description: The Insight Lifetech IVUS System is intended for examination of coronary intravascular pathology only, including TrueVision IVUS diagnostic catheter and VivoHeart IVUS diagnostic device. IVUS imaging is used in patients who will undergo percutaneous coronary intervention.

Intervention type: DEVICE
Intervention: Boston Scientific IVUS System
Description: The Boston Scientific IVUS System is intended for the examination of coronary intravascular pathology only, including Opticross IVUS diagnostic catheter and iLAB IVUS diagnostic device. IVUS imaging is used in patients who will undergo percutaneous coronary intervention.
Study: NCT06350344

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: mobile venous thromboembolism application (mVTEA)
Description: mVTEA will assist in the management of patients with high-risk of VTE during the post-hospitalization follow-up phase. The mVTEA's doctor terminal automatically sends VTE-related health education materials in different frequencies and contents based on the patient's knowledge of VTE prevention and treatment, as well as their risk of thrombosis and bleeding during follow-up. In addition, thrombosis physicians on the mVTEA's doctor terminal can deliver health education to patients based on their condition. This can be done through the mVTEA doctor-patient communication module, which includes text, voice, and video communication.
Study: NCT04851717

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Remimazolam
Description: Remimazolam for intravenous sedation
Study: NCT05151328

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Plecanatide
Description: Plecanatide or Placebo; Route of Plecanatide/placebo administration: tablet; dosage: 3mg, dosage form oral; Frequency of administration: QD

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plecanatide
Description: Plecanatide or Placebo; Route of Plecanatide/placebo administration: tablet; dosage: 3mg, dosage form oral; Frequency of administration: QD
Study: NCT06420648

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Early passive mobilization
Description: a rehabilitation protocol for post-surgical repair of flexor tendons of the hand

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Controlled active motion
Description: a rehabilitation protocol for post-surgical repair of flexor tendons of the hand
Study: NCT06247059

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Box Fan
Description: Classrooms assigned to this arm will be equipped with 2 - 8 box fans each with a single minimum efficiency reporting value-14 (MERV-14) filter sufficient to increase effective air changes per hour to 12 based on the clean air delivery rate measured in cubic feet per minute of the box fan + filter \* 60 divided by the room volume.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: UV Germicidal Irradiation Lamp Unit
Description: Classrooms assigned to this arm will be equipped with one or two 222nm wavelength light ultraviolet germicidal irradiation lamp units (number of units per classroom based on room volume).

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Combined: Box Fan and UV Germicidal Irradiation Lamp Units
Description: Classrooms assigned to this arm will be equipped with both box fans and UV germicidal irradiation lamp units.
Study: NCT06555315

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: 6 mg/kg of oral iron as ferrous sulfate administered every other day.
Description: 6mg/kg of oral iron as ferrous sulfate administered every other day instead of 6 mg/kg of oral iron daily supplementation.

Intervention type: DIETARY_SUPPLEMENT
Group type: OTHER
Intervention: 6 mg/kg of oral iron as ferrous sulfate administered every day.
Description: 6 mg/kg of oral iron as daily ferrous sulfate instead of 6mg/kg of oral iron supplementation administered every other day.
Study: NCT06347276

Intervention type: DEVICE
Intervention: PFO occluder; ASD occluder
Description: Transcatheter closure of atrial septal defect (ASD) and patent foramen ovale (PFO) All cases will be examined with DW-MRI preoperatively, and DW-MRI will be repeated 24 hours and 4 weeks after the transcatheter closure procedure.

Intervention type: DEVICE
Intervention: PFO occluder; ASD occluder
Description: Transcatheter closure of atrial septal defect (ASD) and patent foramen ovale (PFO) All cases will be examined with DW-MRI preoperatively, and DW-MRI will be repeated 24 hours and 4 weeks after the transcatheter closure procedure.
Study: NCT05201183

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Fludarabine + Total Marrow Irradiation
Description: Patients will receive total marrow irradiation TMI on Day -11 to Day -7 in two fractions per day. The TMI dose will be escalated in successive cohorts compromised of 3-6 patients as follows:~Cohort 1 1.4 (Gy/fraction) Cohort 2: 1.6 (Gy/fraction) Cohort 3 1.8 (Gy/fraction) Cohort 4 2.0 (Gy/fraction) Cohort 5 2.2 (Gy/fraction)~Patients will receive Fludarabine (30 mg/m2/day) on Day -6 to Day -2 followed by allo-HSCT on Day 0.
Study: NCT05280431

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: AGREE exoskeleton
Description: Upper limb exoskeleton with four actuated degrees of freedom (shoulder horizontal adduction/abduction, shoulder flexion/extension, humeral rotation, elbow flexion/extension), and one passive degree of freedom (wrist pronation/supination), implementing different rehabilitative strategies.~The intervention consists of the execution of different exercises with the affected arm supported by the AGREE device. The subject is actively involved in the exercises and the system provides different kinds of assistance that can be tailored according to the patient's status.~The following exercises can be performed:~* anterior reaching (in a plane or in the space)~* lateral elevation of the arm~* hand to mouth movements with or without an object in the hand~* moving objects (on a plane or in the space)~* exergames.~A subset of exercises is defined based on the patient's capability.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FEXO exoskeleton
Description: After patient's preparation (tDCS and FES) the FEXO assessment is conducted. The subject performs FEXO assessment games. This stage is also used to calibrate the reach and grasp movement intention EEG patterns. The movement is recorded using internal kinematic sensors; therefore, these measures can be extracted for both reaching and lifting movements. Trunk forward bending is measured to avoid compensatory movements when doing reaching assessment. The clinician then reviews the plan for today's session: game selection, number of repetitions and assistance levels. The patient gets ready to play the games and the clinician starts the first activity of the active stage of FEXO therapy. The patient plays the game and sees his own results. The clinician monitors patient activity, assistance levels, effort and signs of discomfort. The patient plays the next game and sees his own results, and the clinician checks the patient's progress with the results overview.

Intervention type: OTHER
Group type: OTHER
Intervention: Conventional therapy
Description: It consists of a combination of different treatment modalities among the following, based on the patient's specific needs:~* Upper limb passive motion~* Occupational therapy exercises~* Constraint-induced movement therapy~* Upper limb active movement (reaching, grasping, elevation, spatial orientation)~* Repetitive task training