Study: NCT06122714

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part A
Description: Part A: Participants will be administered a single oral dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part B
Description: Part B: Participants will be administered a single dose on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part B
Description: Part B: Participants will be administered a single dose on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part B
Description: Part B: Participants will be administered a single dose on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD4144 Part B
Description: Part B: Participants will be administered a single dose on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Part A
Description: Part A: Participants will be administered a single oral dose of matching placebo on Day 1.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Part A
Description: Part A: Participants will be administered a single oral dose of matching placebo on Day 1.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Part A
Description: Part A: Participants will be administered a single oral dose of matching placebo on Day 1.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Part B
Description: Part B: Participants will be administered a single dose of matching placebo on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Part B
Description: Part B: Participants will be administered a single dose of matching placebo on Day 1, and repeated dosing will commence from Day 4 until Day 11 (inclusive) and a single dose on Day 12.