TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06096259

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: Metformin is an oral anti-hyperglycemic agent widely used as first-line treatment for type II diabetes to improve glycemic control. It is the fourth most commonly prescribed drug in the United States. Participants will receive commercially available extended-release metformin 500mg tablets manufactured by Granules India Limited, Hyderabad, India and then sourced, packaged, and labeled for the study by Sharp Labs. The study will follow standard dosing procedures for extended-release metformin. Participants will begin by taking 1x500 mg pill once a day, and then the dose will be increased in 500 mg/day increments weekly as tolerated, up to a maximum dose of 1500 mg daily.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: The study will use matching placebo tablets that are almost indistinguishable from the 500 mg metformin ER tablets. Participants will begin by taking 1x500 mg pill once a day, and then the dose will be increased in 500 mg/day increments weekly as tolerated, up to a maximum dose of 1500 mg daily.
Study: NCT06030271

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Microcatheter
Description: Support and facilitate the placement of the guidewire in the coronary artery with a CTO.
Study: NCT06320093

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SOUND Intervention
Description: The intervention involved active (vocal and rhythmic production) and passive (listening to musical pieces) musical activities accompanied by motor coordination exercises. It consisted of 12 meetings (2 per week for 6 weeks) of 45 minutes each.
Study: NCT04185701

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SiVIEW software
Description: Eye examination by a technician with the SiVIEW software

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Expert
Description: Eye examination by an expert including optimal correction in distance and near vision
Study: NCT05598645

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Thulium Fibre Laser
Description: Participants will undergo treatment using the TFL

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MOSES Holmium Laser
Description: Participants will undergo treatment using the MOSES Holmium laser.
Study: NCT06537258

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Biofeedback Enhanced Treatment
Description: At all 4 assessment points (T1-T4), HRV will be measured using the ECG module of the mobile MindWare system at a sampling rate of 500 Hz, and a Skin Conductance Response (SCR) will be collected at a sampling rate of 10 Hz using eSense for iPad. Electrodes to assess SCR and HRV will be attached to patients during an \~10-minute period.~A 5-minute initial baseline assessment will occur first followed by three 5-minute stress trials.~Stress tasks will be audio recorded to measure study fidelity, and participants will be asked to rate their subjective level of stress with each trial. At all assessment points (T1-T4), participants will be provided with stool collection kits to collect a stool sample within 3 days of the laboratory psychophysiological assessment.~At all assessment points (T1-T4), a blood draw of approximately 3 ml of blood will be collected.
Study: NCT06537947

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endovascular intervention using the SENTANTE endovascular robotic system
Description: 1. Diagnostic procedure - placement of diagnostic catheter to intended vessel and performing angiography.~2. Percutaneous transluminal angioplasty (PTA)/stenting procedure - placement of balloon catheter or balloon expandable stent to intended vessel and effectively expanding it up to nominal pressure.~3. Coiling procedure - implantation of pushable coils or liquid embolization materials (such as microspheres) to an intended vessel.
Study: NCT04696627

Intervention type: OTHER
Intervention: Questionnaire
Description: Participants from all 3 groups will be interviewed

Intervention type: OTHER
Intervention: Questionnaire
Description: Participants from all 3 groups will be interviewed

Intervention type: OTHER
Intervention: Questionnaire
Description: Participants from all 3 groups will be interviewed
Study: NCT05113862

Intervention type: BIOLOGICAL
Group type: SHAM_COMPARATOR
Intervention: LD Vehicle-GNP
Description: Two intradermal injections in the upper arm spaced 21 days apart

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LD PepGNP-Covid19
Description: Two intradermal injections in the upper arm spaced 21 days apart

Intervention type: BIOLOGICAL
Group type: SHAM_COMPARATOR
Intervention: HD Vehicle-GNP
Description: Two intradermal injections in the upper arm spaced 21 days apart

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: HD PepGNP-Covid19
Description: Two intradermal injections in the upper arm spaced 21 days apart
Study: NCT04886869

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: caffeine
Description: oral consumption

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: caffeine
Description: oral consumption

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: caffeine
Description: oral consumption
Study: NCT06513988

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MI-BCI combined with tDCS treatment
Description: The treatment intervention was carried out in an independent and quite room and included following steps: During the MI-BCI based training, MI of leg flexion and extension training was first performed 10 times to accurate the training threshold, and then later in the formal BCI training, if the attention was reached the threshold, functional electrical stimulator was trigger to stimulate the corresponding muscle to execute the actual action. Additionally, the patient was given a brief training about how to operate tDCS device until he felt comfortable using it, and then asked to show and give feedback to the researcher. For motor function and pain improvement, tDCS is typically delivered with the anode electrode placed over the primary motor cortex (M1), and the cathode over the supraorbital area (SO) to trigger neuroplastic changes\[5\]. The MI-BCI combined with tDCS treatment was performed five days per week (in the late afternoon), and MI-BCI training for 30min.
Study: NCT05527834

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: VNRX-7145
Description: Single oral dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: VNRX-7145
Description: Single oral dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: VNRX-7145
Description: Single oral dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ceftibuten
Description: Single oral dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ceftibuten
Description: Single oral dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ceftibuten
Description: Single oral dose
Study: NCT06298006

Intervention type: OTHER
Intervention: Follow-up
Description: Follow-up of neurocognitive and psychiatric symptoms in Post COVID patients (baseline, 12 months, 24 months) in correlation with biomarkers using MRI, fMRI, neuropsychological testing, lab samples (blood, CSF, microbiota).
Study: NCT04920760

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Vitamin A supplement
Description: The supplementation protocol will be the additional care established by World Health Organization (WHO) and the United Nations International Children ʹs Fund (UNICEF) for measles (1998)(i.e. of 200,000 IU, or 50,000-100,000 IU for children \> 1 or for infants of \< 1 year of age, respectively).
Study: NCT04823598

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Coached pushing and Finnish manual perineal protection
Description: Pushing technique: Rest will be encouraged between uterine contractions. With the onset of uterine contraction, women will be instructed to breathe normally. They will then be instructed to take a deep breath and hold (closed-glottis), and push down strongly for as long as possible (up to 10 seconds). After pushing effort, normal breathing will be encouraged, then the same pushing instruction will be repeated again.~Fetal expulsion: The expulsion rate of the fetal head will be controlled by light pressure applied on the fetal occiput. Simultaneously, the thumb and index finger of the dominant hand will be used to support the perineum, while the bent middle finger will grasp the baby's chin. Once a good grip is achieved, the investigator slowly assists in the expulsion of the fetal head from the vaginal introitus. When most of the fetal head is out, the perineal ring will be pushed under the baby's chin.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Uncoached pushing and Hands-poised perineal protection
Description: Women will not be given any instructions regarding straining and breathing, and will be allowed to follow their own pushing impulses. During the expulsion of the fetal head, the hands of the researcher will be kept in the air and ready for the intervention, but pressure will not be applied to the fetal head or perineum unless necessary (fetal hypoxic appearance, strain detection with a risk of spontaneous laceration towards the anus in the midline).
Study: NCT06534866

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Traditional Physical Therapy
Description: 1. TENS+cold pack (For 10 mins on plantar ascpect of foot)~2. Stretching exercises (5 repetition 2 sets/day) Standing calf stretch Seated plantar fascia stretch Plantar fascia massage Achilles stretch Frozen can roll Towel stretch

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional Physical Therapy
Description: 1. TENS+cold pack (For 10 mins on plantar ascpect of foot)~2. Stretching exercises (5 repetition 2 sets/day) Standing calf stretch Seated plantar fascia stretch Plantar fascia massage Achilles stretch Frozen can roll Towel stretch

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesiotaping
Description: In the first step, after the metatarsophalangeal joints is dorsiflexed, the first strap will be adhered firmly to the posterior heel at its proximal end. The other end of the strap is cut into four slices of equal width. Each slice is applied with a 50% stretch (50% tensile strain) and attached to the plantar forefoot. In the second step, another strap is applied with gentle compression across the bases of the four slices beneath the foot and wrapped around the rearfoot
Study: NCT04757649

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Safety Planning Intervention with Navigation Services
Description: A patient navigation (PN) intervention for SGM youth/emerging adults designed to target mechanisms (i.e., decreasing thwarted belongingness and increasing suicide-related coping skills) that theoretically underlie suicide. The proposed intervention will integrate a single-session, empirically supported, suicide prevention intervention (Safety Planning Intervention; SPI) with PN services (PN+SPI). The patient navigator will deliver the SPI and continue frequent contact for the purpose of providing motivational enhancement, problem-solving, reinforcing coping strategies, and connecting participants to social support and mental health resources (e.g., SGM-specific support groups within the community).
Study: NCT05525624

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TRAMPRE
Description: discharge interventions Transition Model is discharge interventions in parents of preterm infants.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control Group
Description: routine neonatal clinic discharge training of the hospital
Study: NCT06481241

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: CAR-T cells
Description: CAR-T cells as consolidation therapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: VEN
Study: NCT05883306

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [14C]LXI-15028
Description: \[14C\]LXI-15028
Study: NCT05307224

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Mandala
Description: Experimental group will paint mandala for 30 minutes/day in the evenings for six consecutive days. Six pre-selected mandalas were planned to be printed separately on A4 paper. Each patient will be given a new mandala each day. Additionally, At the beginning of the study, the experimental group will be given six colors (yellow, blue, green, red, purple, brown).
Study: NCT06259968

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Neuromuscular electrical stimulation
Description: Patients in the neuromuscular electrical stimulation group will receive neuromuscular electrical stimulation without the concomitant execution of voluntary quadriceps contraction

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Neuromuscular electrical stimulation with superimposed voluntary contraction
Description: Patients will be instructed to perform maximum voluntary contractions superimposed on neuromuscular electrical stimulation
Study: NCT06475157

Intervention type: OTHER
Intervention: No intervention
Description: No intervention is applied.

Intervention type: OTHER
Intervention: No intervention
Description: No intervention is applied.
Study: NCT06342362

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Magnesium sulfate
Description: Participants would be randomly assigned to either the treatment group (receiving magnesium sulfate) or the control group (receiving a placebo or standard treatment).

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo or standard treatment)
Description: placebo or standard treatment)
Study: NCT06175728

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: S-Press
Description: Leg Strengthening Device that can be used in supine and seated positions
Study: NCT04894474

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 767551 intravenous
Description: BI 767551 intravenous

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 767551 inhalation
Description: BI 767551 inhalation

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo intravenous
Description: Placebo intravenous

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo intravenous
Description: Placebo intravenous

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo inhalation
Description: Placebo inhalation

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo inhalation
Description: Placebo inhalation
Study: NCT05933915

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: group-based laughter yoga
Description: Midwives in the intervention group of the research will apply 8 sessions of laughter yoga, 2 sessions a week. Laughter yoga will be practiced by researchers with leadership certification. Each session will take an average of 45 minutes. Laughter Yoga sessions will be held on the web through the Zoom program. Each session will consist of groups of 8 people.
Study: NCT06533163

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Oncomagnetic device
Description: OncoMAGNETX has developed a portable wearable noninvasive magnetic device (Oncomagnetic device) for the treatment of GBM.
Study: NCT06104735

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Synaptic Pairing Interval
Description: Optimize interstimulus pairing between brain and spinal cord stimulation.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Frequency
Description: Compare 2 Hz continuous to intermittent theta burst frequency

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bouts
Description: Compare effects of 1, 2, or 4 bouts of SCAP

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Spacing
Description: Compare 6 versus 12 minutes of rest in between bouts of SCAP

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Exercise
Description: Task-oriented hand exercises

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SCAP plus Exercise
Description: Compare interleaved versus serial bouts of SCAP and exercise.
Study: NCT05995912

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: etoricoxib-tramadol
Description: Oral administration (with or without food)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Naproxen
Description: Oral administration (with or without food)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tramadol
Description: Oral administration (with or without food)
Study: NCT05932537

Intervention type: PROCEDURE
Intervention: Preoperative visualization techniques
Description: describe techniques for pre-operative visualization of subcutaneous contraceptive implants
Study: NCT06123091

Intervention type: OTHER
Intervention: Questionnaires with patient reported outcome measures
Description: Questionnaires to gain insight of the prevalence of extracutaneous manifestations and the impact of the disease on the quality of life.
Study: NCT06338501

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Specifical Functional Training Exercises
Description: Strength Training: Include compound exercises like squats, deadlifts, lunges, and bench presses to build overall strength and muscle mass. Focus on functional movements that mimic the actions used in Muay Thai.~Core Stability Exercises: A strong core is essential for generating power and maintaining balance during strikes and defensive maneuvers.~Plyometric Training: Jumping exercises such as box jumps, squat jumps, and split jumps help improve explosive power and enhance muscular endurance, crucial for delivering swift and powerful strikes.~Flexibility and Mobility Training: Incorporate stretching exercises to improve flexibility, joint range of motion, and prevent injuries.~Interval Training: Perform high-intensity interval training (HIIT) sessions that combine cardiovascular exercises.
Study: NCT06453668

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TCD601
Description: Investigational Product
Study: NCT05100056

Intervention type: OTHER
Intervention: No Intervention
Description: This is a non-interventional study.

Intervention type: OTHER
Intervention: No Intervention
Description: This is a non-interventional study.
Study: NCT06370169

Intervention type: DEVICE
Group type: OTHER
Intervention: Endoscopic ultrasound placement of Coil and glue
Description: The standard treatment of bleeding gastric varices is obliteration with placement of coil and glue
Study: NCT04965311

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Botulinum Toxin Type A
Description: Given via endoscopic injection into intraduodenal sphincter of Oddi segment
Study: NCT06208917

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ondansetron (Oral soluble film OR injections) ,Dexamethasone
Description: Participants will randomly assigned 1:1 to receive treatment (Oral soluble film of Ondansetron plus dexamethasone OR Ondansetron injections plus dexamethasone).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ondansetron (Oral soluble film OR injections) ,Dexamethasone
Description: Participants will randomly assigned 1:1 to receive treatment (Oral soluble film of Ondansetron plus dexamethasone OR Ondansetron injections plus dexamethasone).
Study: NCT05522192

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitoxantrone liposome
Description: Phase I: 24mg/m2, 30 mg/m2, 36mg/m2, IV, d1; Phase II: RP2D.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Phase I/II: 100mg po d1，200mg po d2，400mg po d3-28.
Study: NCT05065242

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioural Therapy
Description: Sleep restriction, Stimulus control, sleep hygiene and cognitive techniques to handle sleep disturbing thoughts.
Study: NCT04980638

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ER004
Description: Intra-amniotic route 100 mg/kg of estimated fetal weight per injection. 3 injections, approximately 3 weeks apart starting from gestational week 26
Study: NCT05685485

Intervention type: PROCEDURE
Intervention: Standard Implantation
Description: Traditional Ahmed plantation without vicryl ligature

Intervention type: PROCEDURE
Intervention: Tied off Tube
Description: Ahmed implantation with vicryl ligature
Study: NCT04572633

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: HistoSonics System
Description: The HistoSonics System (System) is intended for the destruction of liver tissue using histotripsy, a non-thermal, mechanical process using focused ultrasound.
Study: NCT06059703

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Blood punction
Description: Peripheral blood sampling (5 ml) at inclusion and 3 months after treatment

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Central blood sampling
Description: Central blood sampling (2 ml) at inclusion and 3 months after treatment

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intracranial pressure measurement
Description: Intracranial pressure measurement at sinus level with micro-catheter at inclusion and 3 months after treatment
Study: NCT05442411

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ropivacaine 0.75% Injectable Solution
Description: comparison of scalp block vs conventional post operative parecoxib

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ropivacaine 0.75% Injectable Solution
Description: comparison of scalp block vs conventional post operative parecoxib
Study: NCT04265079

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Additional weight at hand
Description: Added weight of an inactive hand orthosis (300 gram)
Study: NCT05406596

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LiquID GCE Use
Description: Use of the LiquID GCE to aid in percutaneous coronary intervention (PCI)
Study: NCT05185024

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ferrous Sulfate Capsules
Description: Once daily dose of one Ferrous Sulfate Capsule for 12 weeks in total.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: >Your< Iron Forte Capsules
Description: Once daily dose of one \>Your\< Iron Forte Capsule for 12 weeks in total.
Study: NCT04772469

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Provision of multiple self-tests
Description: Participants will be given multiple Oraquick Advance HIV-1/2 test kits for testing themselves more frequently and for men in their social networks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Small monetary incentives
Description: Use of small incentive voucher (\~$5) to encourage linkage to confirmatory testing.
Study: NCT05185024

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: >Your< Iron Forte Liquid
Description: Once daily dose of 5 ml of \>Your\< Iron Forte Liquid for 12 weeks in total.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blank Capsules
Description: Once daily dose of one Blank Capsule (excipients only) for 12 weeks in total.
Study: NCT04772469

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Use of SMS/text reminders to motivate adherence to ART or PrEP
Description: Messages will be motivational, will not include any identifying information and will include generic texts such as maintain your good health, to cater for status-neutral language that can work for both HIV positive individuals taking ARVs, as well as HIV-negative individuals on PrEP who may need adherence support.