Study: NCT06137664

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 1 (nOPV1)
Description: Live attenuated novel poliomyelitis virus type 1 at two different dosages, containing middle-dose (MD) 10\^6.0, or high-dose (HD) 10\^6.5 CCID₅₀/dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 2 (nOPV2)
Description: Live attenuated novel poliomyelitis virus type 2 administered at low-dose (LD) 10\^5.3 and HD 10\^5.6 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novel oral poliomyelitis vaccine type 3 (nOPV3)
Description: Live attenuated novel poliomyelitis virus type 3 at two different dosages, containing MD 10\^6.0, or HD 10\^6.5 CCID₅₀/dose.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Bivalent Oral Poliomyelitis Vaccine (bOPV)
Description: Live attenuated poliomyelitis viruses types 1 and 3 (Sabin strains). Each dose (2 drops = 0.1 mL) contains not less than 10\^6.0 infective units of type 1 and 10\^5.8 of type 3.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Bivalent Oral Poliomyelitis Vaccine (bOPV)
Description: Live attenuated poliomyelitis viruses types 1 and 3 (Sabin strains). Each dose (2 drops = 0.1 mL) contains not less than 10\^6.0 infective units of type 1 and 10\^5.8 of type 3.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Bivalent Oral Poliomyelitis Vaccine (bOPV)
Description: Live attenuated poliomyelitis viruses types 1 and 3 (Sabin strains). Each dose (2 drops = 0.1 mL) contains not less than 10\^6.0 infective units of type 1 and 10\^5.8 of type 3.