TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05746234

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Emotion Regulation Course
Description: Each module contains a) the session outline, b) review of previous session's homework, c) theoretical background and module's rationale, d) skills activities, and e) homework assignment.~Each group will attend five 1.5-hour sessions with their allocated instructor. Participants in both groups will receive the same training modules in the same chronological order. For consistency across modalities, participants will receive an instructor's manual containing the core material for facilitating the ER4ALL training, and a companion students' workbook with supporting information and activities.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Emotion Regulation Course
Description: Each module contains a) the session outline, b) review of previous session's homework, c) theoretical background and module's rationale, d) skills activities, and e) homework assignment.~Each group will attend five 1.5-hour sessions with their allocated instructor. Participants in both groups will receive the same training modules in the same chronological order. For consistency across modalities, participants will receive an instructor's manual containing the core material for facilitating the ER4ALL training, and a companion students' workbook with supporting information and activities.
Study: NCT06389266

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Repetitive Transcranial Magnetic Stimulation (rTMS)
Description: rTMS is a technique of TMS that allows the selective external manipulation of neural activity in a non-invasive manner. During TMS, a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field that in turn induces electrical current in neurons and allows the modulation of neural circuitry. The combination of rTMS with functional magnetic resonance imaging allows the selective targeting and modulation of brain networks. The repeated application of rTMS can cause long term changes in behavior and task performance that is reflected in altered brain network connectivity.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Repetitive Transcranial Magnetic Stimulation (rTMS)
Description: rTMS is a technique of TMS that allows the selective external manipulation of neural activity in a non-invasive manner. During TMS, a rapidly changing current is passed through an insulated coil placed against the scalp. This generates a temporary magnetic field that in turn induces electrical current in neurons and allows the modulation of neural circuitry. The combination of rTMS with functional magnetic resonance imaging allows the selective targeting and modulation of brain networks. The repeated application of rTMS can cause long term changes in behavior and task performance that is reflected in altered brain network connectivity.
Study: NCT05162352

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Donafenib+sintilimab
Description: Part 1 (Safety Run-in): donafenib 200mg P.O. BID and sintilimab 200mg I.V. for a 21-days cycle.~Part 2: donafenib at the recommended phase 2 dose determined from Part 1 and sintilimab 200mg I.V. Q3W.~Donafenib will last until disease progresses, intolerable toxicity, withdrawal of informed consent, loss of follow-up, death, or other circumstances that require termination of treatment, whichever occurs first. Sintilimab will last up to 24 months, or until disease progresses, intolerable toxicity, withdrawal of informed consent, loss of follow-up, death, or other circumstances that require termination of treatment, whichever occurs first. Patients will be allowed to have donafenib or sintilimab as a sigle agent and will be still considered on study when the other drug cause intolerable toxicity.
Study: NCT05546957

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: rivaroxaban high dose
Description: Administered orally QD
Study: NCT06051799

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Myofascial trigger points pressure release
Description: Patient lying down in the supine position, Therapist do a first and second finger pincer grasp is performed on the myofascial trigger points located on the upper trapezius muscle and sternocleidomastoid muscle, this pressure will be increased as the therapist perceives a reduction in soft tissue resistance under the finger over a period of 90 seconds. Previous studies indicate no difference between 60 and 90 seconds of pressure. It will be performed on as many trigger points as we find in each muscle associated with the study.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Therapeutic exercise and postural hygiene
Description: Therapeutic exercise and postural hygiene: A progression of exercises with contraction of the deep neck flexor muscles will be included in the first session. Subjects will be taught to perform a slow and controlled craniocervical flexion. Subjects will then be trained to be able to progressively maintain craniocervical flexion through feedback from an air device (Stabilizer™, Chattanooga Group Inc., Chattanooga, TN) placed behind the neck. This sensor monitors the slight flattening of the cervical curve that occurs with contraction of the craniocervical deep flexor musculature. It should be performed at least once a day during the treatment regimen.~Also Postural correction exercises carried out regularly throughout the day, especially when seated. Indications are given to avoid pelvic retroversion and maintain a natural lumbar lordosis while performing retraction and adduction of the scapulae and gently lengthening the spine.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Therapeutic exercise and postural hygiene
Description: Therapeutic exercise and postural hygiene: A progression of exercises with contraction of the deep neck flexor muscles will be included in the first session. Subjects will be taught to perform a slow and controlled craniocervical flexion. Subjects will then be trained to be able to progressively maintain craniocervical flexion through feedback from an air device (Stabilizer™, Chattanooga Group Inc., Chattanooga, TN) placed behind the neck. This sensor monitors the slight flattening of the cervical curve that occurs with contraction of the craniocervical deep flexor musculature. It should be performed at least once a day during the treatment regimen.~Also Postural correction exercises carried out regularly throughout the day, especially when seated. Indications are given to avoid pelvic retroversion and maintain a natural lumbar lordosis while performing retraction and adduction of the scapulae and gently lengthening the spine.
Study: NCT05879276

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Empagliflozin 10 MG
Description: Patients in cardiogenic shock receiving empagliflozin in addition to standard management at a dose of 10 mg per day per os (or through nasogastric tube in intubated patients) for a duration of 12 weeks.
Study: NCT05688605

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MRG003+HX008
Description: Administered intravenously
Study: NCT05267093

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Acupuncture
Description: Sterile single-use stainless steel needles (size 0.3 mm × 25 mm) will be utilized. After local skin disinfection with 75% alcohol wipes, acupuncturists will insert needles perpendicularly into the Ashi points to a depth of approximately 2-3 mm; horizontally into the Baxie points toward the wrist to a depth of 5-10 mm; and perpendicularly into Houxi (SI3) and Waiguan (TE5) to a depth of approximately 5-10 mm. The depth of needling will vary based on the participant's body sizes. After insertion, all needles except those in the Ashi points will be manually manipulated to achieve De qi sensations. All the needles will be retained for 30 min and then gently removed. Participants will take acupuncture treatment three times per week for a total of 12 sessions in 4 consecutive weeks.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Sham acupuncture
Description: The sham needles with blunt tips (size 0.3 mm × 25 mm) will be used in the control group. Acupuncturists will gently lift and twist the sham needles to simulate the treatment procedure, thus blinding the patients to the intervention. Acupuncturist will firstly sterilize the areas of acupoints, then apply the adhesive pads on the surface of Ashi points, Baxie points, Houxi (SI3) and Waiguan (TE5) and insert the sham needles without penetrating. The duration and frequency of treatment sessions will be the same as in the acupuncture group.
Study: NCT05594732

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Weak outdoor light
Description: Stay and stare far on the balcony or under the tree

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Strong outdoor light
Description: Stay and stare far in the sunlight
Study: NCT04958837

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FIFA 11+ protocol with additional Core training exercises
Description: Slow paced running exercises of 8 minutes' duration (2 rounds each), followed by Strength, plyometric and balance exercises including 3 sets of 20-30 sec of The Bench, Sideways Bench each side, Nordic Hamstring strengthening, single leg stance balance training, squatting and high speed running. The protocol will end with additional core training exercises including leg raises, crunches, superman, plank hip twist, and supine bridge. Each exercise plan will be progressively increased. Core training will be followed by 30 sec stretch of major muscle groups.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: FIFA 11+ protocol
Description: Slow paced running exercises of 8 minutes' duration including running straight, running with hip out, running hip in, running circling partner, running shoulder contact and running quickly forward and backwards (2 rounds each), followed by Strength, plyometric and balance exercises including The Bench, Sideways Bench each side, Nordic Hamstring strengthening and single leg stance balance training, squatting and jumping. All exercises will be progressively increased as per established protocol. The final phase of the study includes fast running for 2 minutes.
Study: NCT06287957

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Labrida BioClean
Description: Debriding the tissue around the implant with Labrida Bioclean

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Labrida BioClean
Description: Debriding the tissue around the implant with Labrida Bioclean

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: EMS Handy 3.0 Perio Premium
Description: Debriding the tissue around the implant with Air-Flow Device

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: EMS Handy 3.0 Perio Premium
Description: Debriding the tissue around the implant with Air-Flow Device
Study: NCT05675124

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Needlescopic laparoscopic adrenalectomy
Description: Compared with traditional laparoscopic surgery using 5-12 mm instruments, the wound of needlescopic laparoscopic surgery is smaller. Postoperative pain and recovery are also better than traditional laparoscopic surgery.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: conventional laparoscopic adrenalectomy
Description: conventional laparoscopic adrenalectomy
Study: NCT06439342

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Maribavir
Description: Maribavir tablets
Study: NCT06250192

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtuel education
Description: Randomization to virtuel education based on a tool of small videos accessible via smartphones
Study: NCT05299034

Intervention type: DIAGNOSTIC_TEST
Intervention: Multiparametric imaging
Description: MR perfusion or multiparametric CT including NCCT, CTA and CTP

Intervention type: DIAGNOSTIC_TEST
Intervention: Non contrast CT+CT angiography
Description: NCCT+CTA
Study: NCT05089487

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Nocturnal rest (sleep study)
Description: Proportion of patients free of severe hypoxemia without oxygen therapy during nocturnal rest .
Study: NCT05124587

Intervention type: OTHER
Intervention: No intervention group
Description: No intervention group
Study: NCT06225648

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: threonine
Description: There are 7 different threonine test levels ranging from 5 to 45 mg of threonine per kilogram body weight per day.
Study: NCT05089487

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Nocturnal rest (sleep study)
Description: Proportion of patients free of severe hypoxemia without oxygen therapy during nocturnal rest .
Study: NCT04769141

Intervention type: COMBINATION_PRODUCT
Intervention: CURATE.AI
Description: CURATE.AI is one example of an artificial intelligence guided dosing decision tool. It is customized to each individual and can be applicable across many different conditions, as it is disease agnostic.~This platform has already demonstrated initial success in cancer and transplant populations but yet to be applied to chronic disease patients.

Intervention type: COMBINATION_PRODUCT
Intervention: CURATE.AI
Description: CURATE.AI is one example of an artificial intelligence guided dosing decision tool. It is customized to each individual and can be applicable across many different conditions, as it is disease agnostic.~This platform has already demonstrated initial success in cancer and transplant populations but yet to be applied to chronic disease patients.
Study: NCT04241536

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Blood draw and urine collection
Description: Patients will collect blood and urine for metabolome analysis
Study: NCT05585632

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1010
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1345
Description: Sterile liquid for injection
Study: NCT04328181

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Spectral Photon Counting Computed Tomography (SPCCT)
Description: For the dual-layer spectral CT scanner (IQon®, Philips, Amsterdam, The Netherlands), the following parameters will be used for the acquisition:~* Tube potential 120 kVp;~* Tube current time product of 150 mAs;~* Gantry revolution time 0.33 s;~* Automatic exposure control (angular and longitudinal) combined xyz-axis;~* Beam collimation geometry 64 x 0.625 mm - scan field-of-view - 22 cm;

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: DECT (Dual Energy CT)
Description: The SPCCT scanner is a prototype spectral photon-counting computed tomography system derived from a modified clinical CT system with a field-of-view (FOV) of 168 mm in-plane, and a z-coverage of 20 mm. It is equipped with energy-sensitive photon-counting detectors relying on the direct conversion high band gap semiconductor of cadmium zinc telluride (CZT). The electronics comprises 5 rate counters with 5 different configurable energy thresholds. The SPCCT scanner has the following parameters:~* Base platform : iCT scanner~* Tube Voltage (kVp) : 120, capability for imaging at 80 and 100 kVp~* Tube current (mA) : 10 - 300~* Spatial Resolution : \> 30 lp/cm, ≤ 250 µm~* Z-coverage isocenter (mm) : 20 mm~* FOV (mm) : 500~* Minimum rotation time : 0.33 s/rotation~* Acquisition modes : Axial, Helical, Step \& Shoot
Study: NCT05585632

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1273.214
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1045
Description: Formulation for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1045
Description: Formulation for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1045
Description: Formulation for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1230
Description: Formulation for injection
Study: NCT06089772

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Comparing to Manipulation and Myofascial Release Techniques
Description: Randomized Controlled Trials
Study: NCT05585632

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1230
Description: Formulation for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1230
Description: Formulation for injection
Study: NCT06089772

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Comparing to Manipulation and Myofascial Release Techniques
Description: Randomized Controlled Trials
Study: NCT05656066

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Vibration Intervention
Description: The vibration frequency of the massager, which accelerates blood circulation, is 6000 / min, it works with a 1.5 volt battery. Can be used easily with one hand. The vibration simulator design is based on the gate-control theory, which allows for a reduction in the perceived amount of pain experienced during injection by closing the pain gate in the spinal cord in creating a stimulus on the skin.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Pressure Intervention
Description: Pressure was placed in the ıntramuscular area properly 30 seconds before injection. Then the injection process was completed.
Study: NCT06089772

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Comparing to Manipulation and Myofascial Release Techniques
Description: Randomized Controlled Trials

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Comparing to Manipulation and Myofascial Release Techniques
Description: Randomized Controlled Trials
Study: NCT05193292

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Camrelizumab
Description: 200mg, iv, 21d for a treatment cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab
Description: 8 mg/kg loading dose, followed by 6 mg/kg maintenance, iv, 21d for a treatment cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: XELOX regimen
Description: Oxaliplatin, 130 mg/m2, iv, d1; Capecitabine, 1000 mg/m2, po, bid, d1-d14; q3w

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: mFOLFOX6 regimen
Description: Oxaliplatin, 85 mg/m2, iv, d1; Leucovorin, 400 mg/m2, iv, d1; 5-FU, 400mg/m2, iv, d1 followed by 1200 mg/(m2·d)\*2d, civ, 46h; q2w

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FOLFIRI regimen
Description: Irinotecan, 180 mg/m2, iv, d1; Leucovorin, 400 mg/m2, iv, d1; 5-FU, 400mg/m2, iv, d1 followed by 1200 mg/(m2·d)\*2d, civ, 46h; q2w

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: mXELIRI regimen
Description: Irinotecan, 200 mg/m2, iv, d1; capecitabine, 800 mg/m2, po, bid, d1-d14; q3w

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: mIRIS regimen
Description: Irinotecan, 180 mg/m2, iv, d1; Tiggio Capsules (S-1), 40-60 mg/m2, po, bid, d1-d9; q2w
Study: NCT05211596

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Deaf Weight Wise intervention
Description: The DWW intervention consists of groups of 5 subjects who meet together for 16 weeks, 2 hours each week. Group meetings will be held virtually on Zoom. A trained, deaf, ASL-fluent counselor will lead the sessions. Each session includes group sharing, problem solving, discussion of a weight management topic, and goal setting and action planning for the next week. A key principle of DWW is motivational interviewing, in which the counselor acts as a facilitator to help participants identify/recognize their own unhealthy behaviors, help individuals build skills that will promote behavior change, and help group members to support each other to make behavior changes. The maintenance phase starts immediately after the 16-week intervention, and consists of two meetings of the original group via Zoom; one at month 3 and one at month 6 of the maintenance period. Counselors also email participants bi-weekly to check in and provide additional support.
Study: NCT06318559

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: 3D Robot-assisted laparoscopic radical prostatectomy and pelvic lymphadenectomy
Description: The operation is performed using the Da Vinci HD robotic system which allows the use of laparoscopic instruments, with greater mobility and the possibility of easier and more precise control of movements in three dimensions. Furthermore, the system allows the surgeon a three-dimensional view of the operating field. The surgery is performed under general anesthesia. Six or more trocars are positioned, into which the instruments operated by the robot or directly by the surgical assistants are inserted.~Then a radical prostatectomy is performed.
Study: NCT06184165

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Personalized rTMS
Description: 5 personalized targets accessible to TMS (at less than 3.5 cm distance from the scalp or the coil's hot spot) are placed in the hyper-perfused premotor regions.~The patient is installed on the robotic device. The technician puts a neuro-navigation tracker on the subject's forehead and proceeds to the co-registration. The motor threshold is defined, and stimulator output's intensity is adjusted accordingly (120%) The robotic system ensures that the actual stimulation is performed according to the personalized protocol. This adequacy will be evaluated secondarily based on the recordings of the coil positions during each

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Personalized rTMS
Description: 5 personalized targets accessible to TMS (at less than 3.5 cm distance from the scalp or the coil's hot spot) are placed in the hyper-perfused premotor regions.~The patient is installed on the robotic device. The technician puts a neuro-navigation tracker on the subject's forehead and proceeds to the co-registration. The motor threshold is defined, and stimulator output's intensity is adjusted accordingly (120%) The robotic system ensures that the actual stimulation is performed according to the personalized protocol. This adequacy will be evaluated secondarily based on the recordings of the coil positions during each

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Personalized rTMS
Description: 5 personalized targets accessible to TMS (at less than 3.5 cm distance from the scalp or the coil's hot spot) are placed in the hyper-perfused premotor regions.~The patient is installed on the robotic device. The technician puts a neuro-navigation tracker on the subject's forehead and proceeds to the co-registration. The motor threshold is defined, and stimulator output's intensity is adjusted accordingly (120%) The robotic system ensures that the actual stimulation is performed according to the personalized protocol. This adequacy will be evaluated secondarily based on the recordings of the coil positions during each

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Personalized rTMS
Description: 5 personalized targets accessible to TMS (at less than 3.5 cm distance from the scalp or the coil's hot spot) are placed in the hyper-perfused premotor regions.~The patient is installed on the robotic device. The technician puts a neuro-navigation tracker on the subject's forehead and proceeds to the co-registration. The motor threshold is defined, and stimulator output's intensity is adjusted accordingly (120%) The robotic system ensures that the actual stimulation is performed according to the personalized protocol. This adequacy will be evaluated secondarily based on the recordings of the coil positions during each