TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06538311

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Active rTMS
Description: All study participants will receive one block of ACTIVE rTMS. Each block will consist of daily sessions of active rTMS delivered to the left dorsolateral prefrontal cortex over ten days (Monday through Friday).

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sham rTMS
Description: All study participants will receive one block of SHAM rTMS. Each block will consist of daily sessions of SHAM rTMS delivered to the left dorsolateral prefrontal cortex over ten days (Monday through Friday).
Study: NCT06089239

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: High Intensity Coaching
Description: External coaching is a commonly used strategy to change practice, especially for multi-site collaboratives where implementation requires customization to the site. Coaches serve as skill builders who train organizational personnel in quality improvement processes and develop proficiency in the targeted practice area (i.e., fall prevention).

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Low Intensity Coaching
Description: External coaching is a commonly used strategy to change practice, especially for multi-site collaboratives where implementation requires customization to the site. Coaches serve as skill builders who train organizational personnel in quality improvement processes and develop proficiency in the targeted practice area (i.e., fall prevention).
Study: NCT05398068

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercises and Diet
Description: Non-Invasive Ventilation (NIV) will be included in the treatment program of all patients participating in the study. For the Mediterranean diet protocol planned in training groups; each patient will be evaluated by a dietitian at the beginning of the study and individual diet programs will be planned.~A 10-week exercise training will be planned for the training group.~Aerobic exercise sessions will be planned as a 5-minute warm-up - 20-minute bicycle ergometer - 5-minute cooling-down program. The intensity of exercise will be planned to be of medium intensity according to the heart rate reserve (40-50%). According to the Modified Borg Scale, walking will be given 3 days a week at a intensity of 4-6, also as a home exercise.~Strengthening exercises will be planned with reference to 10 RM (repetition maximum) with theraband for large muscle groups (10 repetitions-3 sets).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Diet
Description: Non-Invasive Ventilation (NIV) will be included in the treatment program of all patients participating in the study. A regular diet program will be planned for 10 weeks for the control group. . For the Mediterranean diet protocol planned in control groups; each patient will be evaluated by a dietitian at the beginning of the study and individual diet programs will be planned. After that, after 1 week, patients will be re-evaluated for compliance by a dietitian. And than, each patient included in the study will be evaluated for 2 weeks during the treatment period.
Study: NCT05877183

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wearable device -'Smart Reminder'
Description: The wearable device, a wristwatch, has a Bluetooth function to link to mobile devices for the participants to view the prescribed videos and engage in telerehabilitation. It has sensors to monitor arm movements and provides multiple feedbacks (auditory, visual and tactile). Participants were instructed to practice the prescribed exercises -tailored according to the severity of UL paresis for the recommended therapy dose. The device recorded the angles of arm movement and the number of repetitions completed and data collected is uploaded to an encrypted cloud server for remote monitoring. Weekly, the participants will receive a 45-minute consultation session to review their progress and modify prescribed exercises based on the wearable device data.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham device
Description: The sham device is also a wristwatch, which consists of an accelerometer, a gyroscope sensor, and a rechargeable battery that supports up to 72 hours of continuous use. The device will monitor the participant's arm activity, but it will not emit any reminders or be connected to a telerehabilitation system. The participants were instructed to perform the exercises from the pictorial handout for the recommended therapy dose and received a weekly therapy consultation as well.
Study: NCT05966662

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: IVL with Shockwave C2+ 2Hz Coronary IVL Catheter
Description: Lithotripsy-enabled, low-pressure balloon dilatation of severely calcified, stenotic de novo coronary arteries prior to stenting.
Study: NCT06044493

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Myreptic-N Tablet
Description: Up to 720mg BID(total 1440mg daily), PO - Check the blood concentration of Mycophenolate at each visit

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Mycophenolate mofetil Tablet/Capsule
Description: Up to 1g BID(total 2g daily), PO - Check the blood concentration of Mycophenolate at each visit
Study: NCT06174987

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: T-DXd
Description: T-DXd (DS8201a) will be administered as an intravenous (IV) infusion, on Day 1 of each 21-day cycle according to the dosage regimens
Study: NCT06616298

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Assessing and Listening to Individual Goals and Needs (ALIGN)
Description: Assessing and Listening to Individual Goals and Needs (ALIGN). ALIGN utilizes the skills of palliative care social workers (PCSWs) trained in family and systems-level theory to address changing preferences for care, family distress, and to facilitate communication across care transitions to improve care aligned with preferences.3 The intervention is implemented virtually in community SNFs and follows patients for 45 days after SNF discharge to reflect real-world patient flow.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Assessing and Listening to Individual Goals and Needs (ALIGN)
Description: Assessing and Listening to Individual Goals and Needs (ALIGN). ALIGN utilizes the skills of palliative care social workers (PCSWs) trained in family and systems-level theory to address changing preferences for care, family distress, and to facilitate communication across care transitions to improve care aligned with preferences.3 The intervention is implemented virtually in community SNFs and follows patients for 45 days after SNF discharge to reflect real-world patient flow.
Study: NCT06692322

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Zongertinib (BI 1810631)
Description: Film-coated tablet

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Zongertinib (BI 1810631)
Description: Film-coated tablet

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Zongertinib (BI 1810631)
Description: Film-coated tablet
Study: NCT06723457

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo collection of blood samples

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo PET/CT

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Epcoritamab
Description: Given SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide
Description: Given PO

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo PET/CT
Study: NCT06730438

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcranial Pulse Stimulation
Description: Patients will receive TPS once a day for five days a week, each session will be separated from the previous one by 24h. Each stimulation and assessment session will be performed at the same hour of the day, in the morning preferably, to maximize the probability of observing responses to stimuli. Patients will be managed in a quiete room with stable light and temperature.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Pulse Stimulation
Description: Patients will receive TPS once a day for five days a week, each session will be separated from the previous one by 24h. Each stimulation and assessment session will be performed at the same hour of the day, in the morning preferably, to maximize the probability of observing responses to stimuli. Patients will be managed in a quiete room with stable light and temperature.
Study: NCT06717399

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mindfulness meditation
Description: Each mindfulness meditation session will be 30 minutes long, consisting of a 5-minute introduction, 15 minutes of guided mindfulness meditation, and 10 minutes of educational discussion.
Study: NCT06725719

Intervention type: DIAGNOSTIC_TEST
Intervention: 18F-DPA714/FDPA
Description: Each subject receive a single intravenous injection of 18F-DPA714/FDPA, and undergo PET/CT or MRI imaging within the specificed time.
Study: NCT06736301

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: a fully covered stent
Description: a double pig-tail stent for cross fixation of a fully covered stent
Study: NCT06736015

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Myo-Inositol 600 mg + Selenium 83 mcg
Description: Myo-Inositol 600 mg + Selenium 83 mcg: 1 tablet once a day for 6 months
Study: NCT06734429

Intervention type: OTHER
Intervention: Urinary Artificial Sphincter
Description: Urinary Artificial Sphincter is a device used for patients with urethral sphincter incompetence
Study: NCT06734481

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sodium bicarbonate pleural lavage
Description: All participants will receive a standardized antimicrobial therapy regimen, with antibiotics selected based on susceptibility testing. Within 2 days of initiating treatment, all patients will undergo catheter placement for continuous drainage of pleural effusion. Participants will receive a daily intrapleural injection of 200 mL of 2.5% sodium bicarbonate in 7 days. For patients with ultrasound evidence of pleural effusion loculations or drainage tube obstruction, intrapleural administration of urokinase may be performed at the discretion of the treating physician to ensure effective drainage.Following each daily injection, the catheter will be clamped for 2 hours before resuming continuous drainage, a process that will continue for 7 days.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline pleural lavage
Description: All participants will receive a standardized antimicrobial therapy regimen, with antibiotics selected based on susceptibility testing. Within 2 days of initiating treatment, all patients will undergo catheter placement for continuous drainage of pleural effusion. Participants will receive a daily intrapleural injection of 200 mL of saline in 7days For patients with ultrasound evidence of pleural effusion loculations or drainage tube obstruction, intrapleural administration of urokinase may be performed at the discretion of the treating physician to ensure effective drainage. Following each daily injection, the catheter will be clamped for 2 hours before resuming continuous drainage, a process that will continue for 7 days..
Study: NCT06734260

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Keverprazan Hydrochloride tablets + high dose amoxicillin
Description: Keverprazan Hydrochloride tablets 20 mg/time, 2 times/day, oral Amoxicillin 1000mg/ time, 3 times/day, oral, for 14 day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Keverprazan Hydrochloride tablets + low dose amoxicillin
Description: Keverprazan Hydrochloride tablets 20 mg/time, 2 times/day, oral Amoxicillin 1000mg/ time, 2 times/day, oral, for 14 day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Keverprazan Hydrochloride tablets + high dose amoxicillin（H-KA-10d）
Description: Keverprazan Hydrochloride tablets 20 mg/time, 2 times/day, oral Amoxicillin 1000mg/ time, 3 times/day, oral, for 10 day
Study: NCT06736457

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: AdvanCore bone grafting
Description: AdvanCore medical device is implanted making sure that is in direct contact with all surfaces of the defect area.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: AdvanCore bone grafting
Description: AdvanCore medical device is implanted making sure that is in direct contact with all surfaces of the defect area.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: AdvanCore bone grafting
Description: AdvanCore medical device is implanted making sure that is in direct contact with all surfaces of the defect area.
Study: NCT06735989

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lecture on moral reasoning
Description: One and a half-hour long lecture on moral justification and moral reasoning

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Lecture on logical reasoning
Description: One and a half-hour long lecture on logical and argumentative principles
Study: NCT06735495

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CD19&CD22 bispecific CAR-T cells
Description: Each patient will receive CD19\&CD22 bispecific CAR-T cells by intravenous infusion on day 0
Study: NCT06736275

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SXRN
Description: SXRN is a naked plasmid DNA drug targeting miRNA. Accelerated titration and 3+3 dose escalation:In light of ethical considerations and with the aim of minimizing the number of patients possibly exposed to potentially ineffective doses, an accelerated titration strategy will be implemented in the early dose escalation phase (2 mg dose group) in this study, with only 1 subject enrolled. If no DLT occurs to the 3 subjects under the given dose in the DLT valuation window (the 1st cycle, 3 weeks), the study will proceed to the next dose (dose escalation in the same subject is not allowed); if one subject develops DLT, 3 additional subject s will be included to the current dose group; if ≥2 DLTs occur in the dose group with 3 or 6 subject s, the dose escalation will be stopped. The decision is made by discussion among the investigators whether to terminate the escalation or consider adjusting the dose for exploration.
Study: NCT06735651

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Wild Blueberry
Description: Daily consumption of 22 g of freeze-dried wild blueberry freeze-dried powder for 6 weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Daily consumption of 22 g of freeze-dried macronutrient-matched placebo powder for 6 weeks
Study: NCT06735326

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluzoparib
Description: Fluzoparib capsule (50mg per capsule) 150mg po BID

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluzoparib
Description: Fluzoparib capsule (50mg per capsule) 150mg po BID

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Bevacizumab injection (100mg per vial) 7.5mg/kg ivdrip Q3W

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Paclitaxel
Description: Paclitaxel injection 135-175mg/㎡ ivdrip Q3W

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carboplatin
Description: Carboplatin injection AUC=4-5 ivdrip Q3W
Study: NCT06735313

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Periodontal examination and saliva collection
Description: Before the periodontal examination, saliva samples are collected from each patient participating in the study and periodontal measurements are made.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Periodontal examination and saliva collection
Description: Before the periodontal examination, saliva samples are collected from each patient participating in the study and periodontal measurements are made.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Periodontal examination and saliva collection
Description: Before the periodontal examination, saliva samples are collected from each patient participating in the study and periodontal measurements are made.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Periodontal examination and saliva collection
Description: Before the periodontal examination, saliva samples are collected from each patient participating in the study and periodontal measurements are made.
Study: NCT06734897

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: music therapy after Cochlear Implantation
Description: The music therapy is specially designed for the rehabilitation of CI-patients. It focuses on learning to distinguish different sound sources, especially when they occur at the same time. Training involves familiarization with different aspects of music such as rhythm, melody, and pitch while at the same time also getting to know the sound of different musical instruments, including singing. The training is also aimed at learning to concentrate on spoken instructions while the music is going on. This latter aim is fundamental to the goal of this study and plays a central role in the therapy.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: music therapy after Cochlear Implantation
Description: The music therapy is specially designed for the rehabilitation of CI-patients. It focuses on learning to distinguish different sound sources, especially when they occur at the same time. Training involves familiarization with different aspects of music such as rhythm, melody, and pitch while at the same time also getting to know the sound of different musical instruments, including singing. The training is also aimed at learning to concentrate on spoken instructions while the music is going on. This latter aim is fundamental to the goal of this study and plays a central role in the therapy.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: no music therapy after Cochlear Implantation
Description: Group C consists of persons who do not receive any music therapy after Cochlear Implantation.
Study: NCT06736145

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional Physical Therapy
Description: Diaphragmatic, Pursed Lip breathing and Targeted cervical muscle stretches 10 repetitions x 1 set, 3 days/week~Total of 9 sessions were given each consisting of 40 mins.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mulligan Glides
Description: Natural Apophyseal Glides of Cervical spine are given 3 repetitions x 3-6 sets, 3 days/week.~Diaphragmatic, Pursed Lip breathing and Targeted cervical muscle stretches 10 repetitions x 1 set, 3 days/week~Total of 9 sessions were given each consisting of 40 mins.
Study: NCT05753345

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Aquatic therapy
Description: Children receive aquatic occupational therapy twice a week for 10 weeks. 30 minutes of aquatic therapy in a warm water pool to increase upper extremity function and swim skills; 15 minutes of self care training to increase independence with dressing and showering.
Study: NCT05254496

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dietary Intervention Classes
Description: Participants will attend classes once per week for 6 months and then bi-weekly for 6 months.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dietary Intervention Classes
Description: Participants will attend classes once per week for 6 months and then bi-weekly for 6 months.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dietary Intervention Classes
Description: Participants will attend classes once per week for 6 months and then bi-weekly for 6 months.
Study: NCT06074198

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SuCCESs
Description: strengthening and endurance exercises
Study: NCT04918238

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional program
Description: All the participants will receive the conventional physical therapy protocol per session as following: Infrared radiation on the low back area for 15 minutes, Ultrasound waves (Digi sonic device) for 10 minutes on the trigger areas of the low back, Myofascial release of the thoracolumbar fascia, Stretching of the Paraspinal muscles and the hamstrings, Mobilization of the lumbar and thoracic spine from a prone lying position and strengthening of abdominal muscles, multifidus and transversal's abdominal muscle.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conventional program
Description: All the participants will receive the conventional physical therapy protocol per session as following: Infrared radiation on the low back area for 15 minutes, Ultrasound waves (Digi sonic device) for 10 minutes on the trigger areas of the low back, Myofascial release of the thoracolumbar fascia, Stretching of the Paraspinal muscles and the hamstrings, Mobilization of the lumbar and thoracic spine from a prone lying position and strengthening of abdominal muscles, multifidus and transversal's abdominal muscle.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Muscle energy technique
Description: The patient was in the lateral recumbent position on the side opposite to his, her side-bending dysfunction while the physiotherapist stood facing the subject. The physiotherapist monitored the lumbar area with one hand while with the other hand flexed the subject's knees and hips until the barrier was engaged at the vertebral segment being treated.
Study: NCT06475391

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: L-arginine
Description: 2 grams iof L-arginine will be ingested before an acute testing bout of exercise tasks in 250 mL of cranberry juice.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06426043

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lusutrombopag
Description: Administer lusutrombopag at 3mg/qd orally for 12 weeks (lusutrombopag starting dose is 3mg, once daily. After 2 weeks of continuous administration, the dose can be increased by 3mg every 2 weeks based on the platelet count and safety of the subject. The dose can be gradually increased to 9mg/d over a total of 12 weeks). The course should be at least 3 months. When the platelet increase is \<20×109/L, the daily dose can be increased by 3mg up to a maximum of 9mg/day; when the platelet increase is ≥50×10\^9/L and ≤200×10\^9/L, the dose can be maintained; when the platelet count is ≥200×10\^9/L and ≤400×10\^9/L, the daily dose can be reduced by 3mg; when the platelet count is \>400×10\^9/L, the drug can be suspended and resumed when the platelet count decreases to \<200×10\^9/L, with the daily dose reduced by 3mg. In this case, if the lowest dose of 3mg/day is used, the drug can be suspended. Responders continue treatment until 6 months.
Study: NCT05679284

Intervention type: RADIATION
Intervention: Low-dose X-ray of subcutaneous tissues
Description: To identify needle fragment retentions, the radiologic imaging of all volunteers will be performed with X-ray using radiation doses as low as reasonably achievable (ALARA) and one projection per anatomic site.

Intervention type: RADIATION
Intervention: Low-dose X-ray of subcutaneous tissues
Description: To identify needle fragment retentions, the radiologic imaging of all volunteers will be performed with X-ray using radiation doses as low as reasonably achievable (ALARA) and one projection per anatomic site.