TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04669821

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HSK3486
Description: Loading Dose：0.1 mg/kg，Maintenance Dose：Maintenance is started at 0.3 mg/kg/h, and the dose can be adjusted up and down by 0.05-0.1 mg/kg/h.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol
Description: Loading Dose：0.5 mg/kg，Maintenance Dose：Maintenance is started at1.5 mg/kg/h, and the dose can be adjusted up and down by 0.25-0.5mg/kg/h.
Study: NCT00781755

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: varenicline
Description: .5mg/day for 3 days then titrated to 1.0mg/day for 11 days. A total dosing regimen of 14 days.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Adaptation of Motivational Interviewing
Description: 2 sessions of behavioral intervention designed to create ambivalence about quitting or plan for a quit attempt if the patient is ready.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Adaptation of Motivational Interviewing
Description: 2 sessions of behavioral intervention designed to create ambivalence about quitting or plan for a quit attempt if the patient is ready.
Study: NCT05079737

Intervention type: OTHER
Intervention: Mutation Burden
Description: Subjects will have their facial samples analyzed for DNA mutation burden.

Intervention type: OTHER
Intervention: Mutation Burden
Description: Subjects will have their facial samples analyzed for DNA mutation burden.
Study: NCT05738109

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Self-Talk Journals
Description: Participants randomized to the intervention group will receive a physical copy of the 91-day self-talk journal during the baseline meeting. Participants will also be introduced the purpose of the journal and its intended usage (i.e., daily journaling). Intervention participants will not be offered guidance or feedback on the journal after these initial instructions, in order to emulate an ad libitum usage. Control group participants will not receive any contact with the researchers outside of the planned questionnaires and to receive their journal at the three-month timepoint.
Study: NCT05699707

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: (R)-3-hydroxybutyl (R)-3-hydroxybutyrate ketone monoester
Description: Participants will consume a ketone monoester drink (0.75 k/kg body mass) with venous blood samples obtained before and after (30, 60 and 90 minutes) drink consumption.
Study: NCT05832450

Intervention type: OTHER
Intervention: Red cell concentrate transfusion
Description: Perioperative data of patient undergoing elective brain tumor resection with requirements of red cell concentrate transfusion.
Study: NCT05118685

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Conjugated Estrogens vaginal cream 0,625mg
Description: the particepant will receive vaginal estrogen cream one tube every night for 14 nights; then, one tube for 2 nights in 1 week (two tubes every week) for 10 weeks.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: platelet rich plasma
Description: First, a topical anesthetic cream will be applied to the vaginal wall. Delaying the PRP injection for 20 minutes after anesthetics application achieved complete or near-complete analgesia for the procedure. Peripheral blood will be drawn from the arm and centrifuged to yield 5 cc of PRP. then PRP will be administered to the anterior vaginal wall using 27-G needles once every 3 weeks for 4 times and PRP is mainly injected into the anterior wall of the vagina to increase the tactile sensitivity of the injection site.
Study: NCT06177158

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: oral hygiene instructions
Description: Standardized motivation and oral hygiene instructions regarding the tooth brushing will be demonstrated to all three groups using modified bass technique and a standardized brush, medium bristled brush with toothpaste, the patients will be instructed to brush their teeth for 2 minutes with a pea- size amount of dentifrice twice daily. For interdental cleaning aids each patient will be instructed to use the suitable methods regarding the space between teeth.~clinically for each patient to ensure that the patients understood the instruction sessions. Before receiving oral hygiene instructions and motivation, the salivary sample will be collected and clinical periodontal parameters will be measured at a base line visit then, after 3 weeks, saliva will be collected and the same clinical measurements will be taken.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: oral hygiene instructions
Description: Standardized motivation and oral hygiene instructions regarding the tooth brushing will be demonstrated to all three groups using modified bass technique and a standardized brush, medium bristled brush with toothpaste, the patients will be instructed to brush their teeth for 2 minutes with a pea- size amount of dentifrice twice daily. For interdental cleaning aids each patient will be instructed to use the suitable methods regarding the space between teeth.~clinically for each patient to ensure that the patients understood the instruction sessions. Before receiving oral hygiene instructions and motivation, the salivary sample will be collected and clinical periodontal parameters will be measured at a base line visit then, after 3 weeks, saliva will be collected and the same clinical measurements will be taken.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: oral hygiene instructions
Description: Standardized motivation and oral hygiene instructions regarding the tooth brushing will be demonstrated to all three groups using modified bass technique and a standardized brush, medium bristled brush with toothpaste, the patients will be instructed to brush their teeth for 2 minutes with a pea- size amount of dentifrice twice daily. For interdental cleaning aids each patient will be instructed to use the suitable methods regarding the space between teeth.~clinically for each patient to ensure that the patients understood the instruction sessions. Before receiving oral hygiene instructions and motivation, the salivary sample will be collected and clinical periodontal parameters will be measured at a base line visit then, after 3 weeks, saliva will be collected and the same clinical measurements will be taken.
Study: NCT05143827

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pasta manufactured with traditional wheat varieties (Senatore Cappelli, Korasan)
Description: A single meal composed of a portion of pasta (with standardized dressing) manufactured with different wheat varieties

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pasta manufactured with traditional wheat varieties (Senatore Cappelli, Korasan)
Description: A single meal composed of a portion of pasta (with standardized dressing) manufactured with different wheat varieties

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Pasta manufactured with current wheat varieties (Claudio)
Description: A single meal composed of a portion of pasta (with standardized dressing) manufactured with different wheat varieties
Study: NCT06328725

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: EN001
Description: Phase 1~* Cohort 1: EN001 5.0x10\^5 cells/kg administered intravenously (IV) 3 times at 6 week intervals.~* Cohort 2: EN001 2.5x10\^6 cells/kg administered intravenously (IV) 3 times at 6 week intervals.~Phase 2~* Experimental Group: The recommended phase 2 dose (RP2D) of EN001 is administered intravenously (IV) three times at six-week intervals.~* Control Group: EN001 placebo is administered intravenously (IV) three times at six-week intervals.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: EN001
Description: Phase 1~* Cohort 1: EN001 5.0x10\^5 cells/kg administered intravenously (IV) 3 times at 6 week intervals.~* Cohort 2: EN001 2.5x10\^6 cells/kg administered intravenously (IV) 3 times at 6 week intervals.~Phase 2~* Experimental Group: The recommended phase 2 dose (RP2D) of EN001 is administered intravenously (IV) three times at six-week intervals.~* Control Group: EN001 placebo is administered intravenously (IV) three times at six-week intervals.
Study: NCT05195931

Intervention type: DIAGNOSTIC_TEST
Intervention: preload challenge
Description: reduction in preload by head-up tilt and increase in preload with saline infusion

Intervention type: DIAGNOSTIC_TEST
Intervention: afterload challenge
Description: reduction in afterload with nitroprusside and increase in afterload with phenylephrine

Intervention type: DIAGNOSTIC_TEST
Intervention: contractility assessment
Description: heart rate changes will be made by increasing heart rate with external pacemaker/defibrillator. Contractility will be adjusted by dobutamine infusion. Patients will exercise at a constant pump speed and also with pump speed increases.
Study: NCT05454150

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: balloon-expandable valve
Description: Sapien 3/Ultra, Edwards Lifesciences©

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: self-expanding valve
Description: Evolut R/Pro, Medtronic©
Study: NCT05439902

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tamsulosin
Description: One 0.4mg Tamsulosin capsule taken per day for 30 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: one placebo capsule per day for 30 days. with identical appearance (color and size) to the experimental drug, composed of microcrystalline cellulose
Study: NCT04746573

Intervention type: DEVICE
Intervention: Natrox Topical Oxygen Therapy
Description: Device delivering humidified oxygen directly to the wound bed
Study: NCT05492266

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Expiratory Muscle Strength Training
Description: At visit 1, participants will be block randomized based on PWSS score (3-6 or 7+) to Expiratory Muscle Strength Training (EMST) for 6 to 8 weeks or no exercises. Participants in the EMST-150 group will perform 5 sets of 5 resistive expirations once a day with a 10-15 second rest between each repetition and a 1-2 minute rest between each set of 5 repetitions.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Expiratory Muscle Strength Training
Description: At visit 1, participants will be block randomized based on PWSS score (3-6 or 7+) to Expiratory Muscle Strength Training (EMST) for 6 to 8 weeks or no exercises. Participants in the EMST-150 group will perform 5 sets of 5 resistive expirations once a day with a 10-15 second rest between each repetition and a 1-2 minute rest between each set of 5 repetitions.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Expiratory Muscle Strength Training
Description: At visit 1, participants will be block randomized based on PWSS score (3-6 or 7+) to Expiratory Muscle Strength Training (EMST) for 6 to 8 weeks or no exercises. Participants in the EMST-150 group will perform 5 sets of 5 resistive expirations once a day with a 10-15 second rest between each repetition and a 1-2 minute rest between each set of 5 repetitions.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Maintenance Training
Description: At visit 2, participants with improved (decreased) PWSS of 2 or more points, for whom the family and/or surgeon is not currently considering surgical intervention for VPI, will be further randomized to continue maintenance EMST exercises or no exercises for 6 months. Participants in the maintenance group will complete 3-5 sessions exercise sessions each week (rather than daily training), with 2 sets of 5 resistive expirations (rather than 5 sets)
Study: NCT00932776

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TBA care device
Description: Tracheal suction maneuvers are performed according to the indications provided by the TBA care device or to clinical parameters whichever occurs first.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: In this group suction maneuvers are performed according to clinical indications or on a fixed schedule whichever comes first.
Study: NCT06064396

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Gong's Mobilization
Description: The duration of intervention will be 4 weeks, 3 sessions a week, a total of 12 sessions will be given to the study participants. Each session will last for 30 minutes. Conventional physical therapy will be given to participants along with Gong's Mobilization.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gong's Mobilization
Description: The duration of intervention will be 4 weeks, 3 sessions a week, a total of 12 sessions will be given to the study participants. Each session will last for 30 minutes. Conventional physical therapy will be given to participants along with Gong's Mobilization.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Stecco Fascial Therapy
Description: The duration of intervention will be 4 weeks, 3 sessions a week, a total of 12 sessions will be given to the study participants. Each session will last for 30 minutes. Conventional physical therapy will be given to participants along with stecco fascial therapy.
Study: NCT06457555

Intervention type: OTHER
Intervention: type of parallel data in a convergent parallel hash pattern (near time)
Description: This study is a mixed method research conducted to determine the knowledge levels and experiences of nurses working in adult intensive care units regarding the prevention of pressure sores. In accordance with the purpose of the study, parallel data type in convergent parallel mixed design will be used as the research design. The quantitative phase will be conducted as a descriptive survey, and the qualitative phase will be conducted as a descriptive case study design. In this mixed design, equal priority, parallel timing and combining results during interpretation are planned.
Study: NCT06005805

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Mastic gum
Description: Mastic gum 3g/pack daily for 21 days

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Dietary modification
Description: Adhere to the dietary recommendations for Korean dyspepsia patients

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dietary modification
Description: Adhere to the dietary recommendations for Korean dyspepsia patients
Study: NCT05588726

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Sleep Hygiene
Description: Once weekly coaching calls with advice on sleep hygiene

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Sleep Hygiene
Description: Once weekly coaching calls with advice on sleep hygiene

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness
Description: Once weekly coaching calls with advice on mindfulness
Study: NCT04683926

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Desmetramadol
Description: Analgesic

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Desmetramadol
Description: Analgesic

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Desmetramadol
Description: Analgesic

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Desmetramadol
Description: Analgesic
Study: NCT05759195

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Biomolecular tumor analysis
Description: NGS analysis, other molecular analyses on FFPE tumor tissue
Study: NCT05476874

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Open Mini-Laparotomy
Description: A 5-cm paraumbilical skin is made, and the abdominal wall is incised in layers. The distal catheter tip is inserted into the peritoneal cavity in a craniocaudal direction, and the abdominal wound is sutured in layers.
Study: NCT06580522

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Prone Position Group
Description: After the children in the prone position group were weaned from noninvasive mechanical ventilation according and started to breathe spontaneously, they were prone positioned and monitored for 120 minutes (2 hours) every 20 minutes (0.min, 20.min, 40.min, 60.min, 80.min, 100.min, 120.min) with a head-monitor for peak heart rate, oxygen saturation, respiratory rate and blood pressure.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supine Position Group
Description: After the children in the supine position group were weaned from noninvasive mechanical ventilation according and started to breathe spontaneously, they were supine positioned and monitored for 120 minutes (2 hours) every 20 minutes (0.min, 20.min, 40.min, 60.min, 80.min, 100.min, 120.min) with a head-monitor for peak heart rate, oxygen saturation, respiratory rate and blood pressure.
Study: NCT06579703

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketorolac
Description: Randomized to a single dose of:~Arm A: 15 mg/mL (per mL) Arm B: 30 mg/mL (per mL)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ketorolac
Description: Randomized to a single dose of:~Arm A: 15 mg/mL (per mL) Arm B: 30 mg/mL (per mL)
Study: NCT06580795

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Student citizens' assembly
Description: The intervention consists in participating in a deliberative mini-public, a student citizens' assembly whose mission is to to co-create a list of concrete proposals that would improve the access of USPN students to sustainable diets and physical activity
Study: NCT06580977

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: cardiovascular training
Description: Cardiovascular training will be performed in supervised sessions and in small groups of 2-5 persons at the study site. The training is performed on a cycle ergometer at 60% of peak power output (Wmax) for 30 min (i.e., 5 min warm-up, 20 min at 60% Wmax, 5 min cool-down) three times a week for twelve weeks. The exercise program will be increased by 5 min (max. 55 min) and 5% of intensity (in Watt) every two weeks. If participants report a too low (i.e., Borg scale ≤ 11) or too high (i.e., Borg scale ≥ 16) subjective rate of perceived exertion (RPE; Borg scale 6-20) intensity will be increased or decreased until the target levels are met (i.e., Borg scale 12-15). During training, heart rate, intensity (in Watt) and RPE will be monitored. Participants missing training sessions will be offered an additional week to perform up to three training sessions.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: stretching
Description: The stretching training will be performed in supervised sessions and in small groups of 2-5 persons at the study site. Stretching training consists of lying, seated, and standing flexibility exercises (according to the recommendations of the American Parkinson´s Disease Foundation and the Parkinson Society Canada) for 30 min (i.e., 5 min warm-up, 20 min main part, 5 min cool-down) three times a week for twelve weeks. The exercise program will be increased by 5 min (i.e., adding additional repetitions and exercises; max. 55 min) every two weeks. Intensity of stretching exercises will be assessed by subjective rate of perceived muscle tension on a visual analog scale (VAS) from 0 to 10 and will be moderate defined as 5 to 7 on the VAS. During training VAS, heart rate, and RPE will be monitored. Participants missing training sessions will be offered an additional week to perform up to three training sessions.
Study: NCT06580223

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aspirin 100mg
Description: Aspirin, enteric coating of tablets, oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rivaroxaban 10mg
Description: Rivaroxaban, tablets, oral administration.
Study: NCT04833387

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PD-1 antibody
Description: Capecitabine:Dose of 1650mg/m2,14days; Radiation:50Gy/25 fractions;IBI308: 200mg on day1 of each cycle, 3 cycles; Surgical therapy:The resection (LAR), intersphincteric resection (ISR), or abdominoperineal resection (APR)
Study: NCT05894941

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Corrective Exercises
Description: A total of 6 evidence-based exercises and stretches namely; Upper trapezius stretch, Sternocleidomastoid stretch, pectoral stretch; Chin tuck exercise, YTWL exercise, and resisted/isometric neck extension exercise will be prescribed to the exercise group while the postural education group will follow the guidelines provided by National Institutes of Health (NIH) for using computers and other sources. The control group will receive no intervention.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Postural Education
Description: Postural guidelines for doing daily activity especially sitting for prolonged periods and using electronic devices like computers and other electronic devices.
Study: NCT05772780

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MP-3 microperimeter
Description: Biofeedback stimulation two days a week

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MP-3 microperimeter
Description: Biofeedback stimulation two days a week

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MP-3 microperimeter
Description: Biofeedback stimulation three days a week

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MP-3 microperimeter
Description: Biofeedback stimulation three days a week
Study: NCT06397131

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: NT-501 CNTF Implant
Description: Single implantation of CNTF-secreting NT-501 hCNTF device into one eye.
Study: NCT05098054

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat
Description: Soticlestat tablets.
Study: NCT05476874

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Abdominal Puncture
Description: An about 0.5-cm paraumbilical incision made to allow introduction of a splitable trocar. The trocar is pierced through the abdominal wall into the abdominal cavity. Pull out the puncture cone, and adjust the trocar towards the pelvis. The distal catheter tip is inserted into the peritoneal cavity through the puncture cannula. Then the splitable puncture cannula is split apart and removed. The skin incision requires only one stitch.
Study: NCT06454500

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinical decision support
Description: A 48 hour expiration on orders placed for indwelling urinary catheters.
Study: NCT05098054

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat
Description: Soticlestat tablets.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat
Description: Soticlestat tablets.
Study: NCT05059535

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: standard pain relievers
Description: Knee arthroscopy will be performed ansd patients will receive standard pain relievers in confomtity with the current practice
Study: NCT06089356

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: zolmitriptanee
Description: zolmitriptane tablet daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: topiramate
Description: topiramate once daily