TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04889339

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Test brace versus control brace: Immediate correction
Description: The trunk surface will be scanned to reconstruct a numerical model of the patient's trunk, this reconstruction will help to produce the optimized brace. The patient skeletal will also be reconstructed from a bilateral radiograph using an EOS imaging system. Each patient will try both the control and the test brace. Radiographic and patient-reported data will be gathered and analyzed to observe changes between the immediate correction of the braces. The SRS-22r will be collected. The study protocol requires no additional visits beyond the standard of care. There will be one additional radiograph compared to the standard of care.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Test brace versus control brace: Long-term correction
Description: After comparing the immediate correction of the braces, each patient will be using either the test or the control brace for a period of two years. There will be follow-up visits, between 6 months and 1 year depending on the patient growth. The brace will be renewed using the same procedure to adapt to the patient's growth. The study protocol requires no additional visits beyond the standard of care. There will be no additional radiograph compared to the standard of care. Compliance monitors are installed in each brace.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Test brace versus control brace: Long-term correction
Description: After comparing the immediate correction of the braces, each patient will be using either the test or the control brace for a period of two years. There will be follow-up visits, between 6 months and 1 year depending on the patient growth. The brace will be renewed using the same procedure to adapt to the patient's growth. The study protocol requires no additional visits beyond the standard of care. There will be no additional radiograph compared to the standard of care. Compliance monitors are installed in each brace.
Study: NCT06242587

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Pericoccygeal nerve block
Description: The coccygeal corneas are visualised with a linear probe under ultrasound guidance. The pericoccygeal nerves are located medial to the cornu and a combination of local anaesthetic and dexamethasone is injected.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Impar ganglion block
Description: The sacrum is visualised with fluoroscopy. A needle is inserted through the sacrococcygeal junction. The optimal image is obtained by administering contrast material. A combination of local anaesthetic and dexamethasone is injected.
Study: NCT04713033

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: surface electromyogram (sEMG)
Description: A device that measures electrical signals from your skin will be connected to those stickers and will make a graph that is characteristic to your vocal function.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: surface electromyogram (sEMG)
Description: A device that measures electrical signals from your skin will be connected to those stickers and will make a graph that is characteristic to your vocal function.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: surface electromyogram (sEMG)
Description: A device that measures electrical signals from your skin will be connected to those stickers and will make a graph that is characteristic to your vocal function.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: flexible laryngoscopy
Description: A device that examines the throat and nasal passages. The flexible laryngoscope or scope consists of an eyepiece and a fiber-optic light enclosed in a thin, flexible tube. The scope looks like a strand of black spaghetti with a tiny light on the end of it. The scope is inserted through the nose, and can be moved around to help the doctor see all areas of the nasal passages and throat.
Study: NCT06418841

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computer-Assisted Paramedian Approach Technique
Description: Computer-Assisted Paramedian Approach Technique

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Conventional Midline Approach Technique
Description: Conventional Midline Approach Technique
Study: NCT05287048

Intervention type: DIAGNOSTIC_TEST
Intervention: MCM5 ELISA
Description: ADXGYNAE is a non-invasive ELISA utilising a combination of two monoclonal antibodies for the detection of MCM5 in urine sediment. It is intended to aid in the detection of endometrial cancer in women with postmenopausal bleeding who are suspected of having endometrial cancer. Participants will be asked to provide a urine specimen, which will be centrifuged before the sediment is lysed. The lysed sample will then be tested with the MCM5 ELISA.
Study: NCT05505201

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Repetitive transcranial magnetic stimulation
Description: Repetitive transcranial magnetic stimulation (rTMS) is a noninvasive intervention that uses magnetic fields to stimulate nerve cells to improve the symptoms of a variety of disorders, including stroke-related motor impairment.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Repetitive transcranial magnetic stimulation
Description: Sham Repetitive transcranial magnetic stimulation
Study: NCT05749575

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide Plus Toripalimab Plus Paclitaxel
Description: Each participant receives chidamide plus toripalimab plus paclitaxel
Study: NCT05232240

Intervention type: DIAGNOSTIC_TEST
Intervention: blood pressure variability measured by ambulatory 24-hour blood pressure monitoring
Description: The ambulatory 24-hour blood pressure monitoring will be performed at baseline and one year after the enrollment. Various blood pressure variability characteristics will be obtained from these examinations.
Study: NCT05195463

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise intervention
Description: Women with diastasis recti abdominis will do core stabilization exercises for the transversus abdominis muscle with 10 repetitions 3 days a week for 8 weeks. The exercises include diaphragmatic breathing exercises, core stabilization exercises for the transversus abdominis muscle, and pelvic floor contractions

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise intervention by wearing abdominal corset
Description: In this group, in addition to the first group, core stabilization exercises will be performed by wearing an abdominal corset. Participants will be asked to wear their corsets while performing their exercises.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Corset intervention
Description: Participants included in this group will be required to wear only this corset all day (except for the bathroom) for 8 weeks.
Study: NCT04915833

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Standard high-definition colonoscopy
Description: Evaluation of the colonic mucosa with a high definition colonoscope (EPKi7010 video processor).~The endoscopy images will be seen on a 27inch, flat panel, high-definition LCD monitor (Radiance™ ultraSC-WU27-G1520 model) only by one expert endoscopist, randomly assigned.~The number, location and polyps' features (Paris classification) will be recorded by the operator. If a polyp is detected, the endoscopist will remove the polyp endoscopically with a cold snare and forceps biopsy.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Colonoscopy with real-time AI assisted automated polyp detection
Description: The same patient will be submitted to a second, same session, computed aided real-time colonoscopy using the DISCOVERY, AI assisted polyp detector. Colonoscopy will be performed by a same-level-of-expertise operator in comparison to the initial procedure. Any polyp or lesion detected with the AI system will be recorded and endoscopically removed and considered as a missed lesion from standard colonoscopy.
Study: NCT05109988

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Breastfeeding telephone support
Description: The intervention consists of four weekly 20-30 minutes telephone-administered counselling sessions on breastfeeding, delivered individually in the first month postpartum for mothers and fathers.
Study: NCT05023265

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic body radiotherapy
Description: SBRT is a non-invasive treatment approach that delivers precise and highly conformal radiotherapy to the tumour with steep dose gradients that minimize exposure to the surrounding normal tissues.
Study: NCT05126784

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AVT03
Description: AVT03 (biosimilar to denosumab) will be given as single subcutaneous injection

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Prolia
Description: Prolia (denosumab) will be given as single subcutaneous injection
Study: NCT06431854

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ED-MINERVA Program
Description: ED-MINERVA Program aims to improve ED symptoms and related difficulties of the patient and provide tools to enhance the family's management (nutritionally, emotionally, and behaviorally) in their natural environment. The treatment consists of four phases with a gradually decreasing therapeutic intensity, ranging from total hospitalization, family treatment apartment, to home treatment and subsequent linkage with specialized local facilities. The ED-MINERVA program uses various aspects of family-based treatment, cognitive behavioral therapy, dialectical behavioral therapy, and systemic family therapy.
Study: NCT05701410

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: DPD scintigraphy
Description: Bone tracer scintigraphy, diagnostic for transthyretin amyloidosis.
Study: NCT05302544

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mixed Reality training
Description: Mixed Reality training: Mixed Reality game with appearance of virtual balloons in the game area that the subject must find and pierce with finger

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: motor activities
Description: motor activities usually performed

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: motor activities
Description: motor activities usually performed
Study: NCT05204654

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: In-office fabricated appliance
Description: A 0.022 Slot MBT™ second molar mini tube that has been modified to have a 2 mm length will be placed on the maxillary first molar and a 0.018 slot MBT™ maxillary canine bracket will be placed on the maxillary canine, with a 0.016x0.022 stainless-steel wire spanning from the maxillary first molar to the maxillary canine. A bayonet bend will be placed mesial to the molar tube. A curve will be bent into the wire, so that the wire is able to passively rest on the buccal surface of the maxillary canine. A stainless-steel closed coil will span the molar to canine and lay flush to the mesial portion of the molar tube and the distal portion of the canine bracket. The wire will be cinched mesial to the maxillary canine tie-wing and also 2-3 mm distal to the maxillary first molar to ensure that the molar can rotate during treatment, if needed. A stainless-steel tie will be used to secure the wire into the canine bracket. AP correction will be completed following CMA protocol

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Carriere Motion Appliance
Description: A bar spanning from the maxillary first molar to canine with a ball and socket joint at the molar and a canine pad at the canine. A slight bend is present between the molar and canine bracket. The ball and socket is designed to allow the molar to rotate to -15 degrees along it's longitudinal axis. The appliance claims that it allows for Class II correction with minimal secondary tooth movements when used with mandibular anchorage.
Study: NCT04704440

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Normobaric hypoxia (FiO2 15%)
Description: Inhalation of deoxygenated air through an altitude simulator (Altitrainer), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Placebo-ambient air (FiO2 21%)
Description: Inhalation of room air through an altitude simulator (Altitrainer), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Normobaric hypoxia (FiO2 15%) under Sildenafil
Description: Inhalation of deoxygenated air through an altitude simulator (Altitrainer), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo-ambient air (FiO2 21%) under Sildenafil
Description: Inhalation of room air through an altitude simulator (Altitrainer), for approx. 1/2 hour given by a facemask, first at rest and then during exercise.
Study: NCT05783362

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Conditioned Pain Modulation (CPM)
Description: Participants will receive a testing stimulus of pressure applied per ascending intensity at the web space of the foot until the pain reaches 40 out of 100, then discontinued. After testing the stimulus, participants will then receive a conditioning stimulus by immersing the non-dominant hand into the water-cooled by refrigeration unit with a temperature of 6 degree Celsius (males) or 8 degree Celsius (females) for 60 seconds. Subjects will be asked to rate the cold pain during the four 60-second trials. Participants completely removed their hand from the cold pressor for 30 seconds following each of the four 60-second immersions, during which time the testing stimulus will be re-applied per the sequential paradigm to the web space of the foot. Participants complete four 60-second periods of immersion. Conditioned pain modulation will be calculated as the average pain ratings of the second testing stimulus series minus the average pain ratings of the first testing stimulus series.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Conditioned Pain Modulation (CPM)
Description: Participants will receive a testing stimulus of pressure applied per ascending intensity at the web space of the foot until the pain reaches 40 out of 100, then discontinued. After testing the stimulus, participants will then receive a conditioning stimulus by immersing the non-dominant hand into the water-cooled by refrigeration unit with a temperature of 6 degree Celsius (males) or 8 degree Celsius (females) for 60 seconds. Subjects will be asked to rate the cold pain during the four 60-second trials. Participants completely removed their hand from the cold pressor for 30 seconds following each of the four 60-second immersions, during which time the testing stimulus will be re-applied per the sequential paradigm to the web space of the foot. Participants complete four 60-second periods of immersion. Conditioned pain modulation will be calculated as the average pain ratings of the second testing stimulus series minus the average pain ratings of the first testing stimulus series.
Study: NCT06155942

Intervention type: PROCEDURE
Group type: OTHER
Intervention: 7 Tesla MRI
Description: Patients will have a 7T MRI and questionnaires

Intervention type: PROCEDURE
Group type: OTHER
Intervention: 7 Tesla MRI
Description: Patients will have a 7T MRI and questionnaires

Intervention type: PROCEDURE
Group type: OTHER
Intervention: 7 Tesla MRI
Description: Patients will have a 7T MRI and questionnaires
Study: NCT06362187

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Gut Directed VR
Description: The VR experiences follow a protocolized gut-directed therapy

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Control VR
Description: The same Oculus Quest 2 device as the active treatment group but will use distractive therapy
Study: NCT04882228

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Entelon Tab.150mg
Description: twice daily for 8 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Venitol Tab.
Description: twice daily for 8 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo of Venitol Tab.
Description: twice daily for 8 weeks (with Entelon Tab.150mg. It is for the masking.)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo of Entelon Tab.150mg
Description: twice daily for 8 weeks(with Venitol Tab. It is for the masking.)
Study: NCT05212714

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: taVNS
Description: The non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) device that will be used in this study is a wearable TENS unit called the Vorso STIM100 System. The Vorso system consists of a wearable, external stimulator, a neural interface ear piece, and an arm band designed to be safe for human contact. The external stimulator generates electrical pulses that are transcutaneously delivered to the auricular branch of the vagus nerve through the ear canal. The ear piece contains 4 electrodes that carry current from the external stimulator to the auricular branch of vagus nerve. The external stimulator connects to a flexible arm band that attaches to the upper arm for ease of use during each stimulation session. The type of stimulation (including shape, frequency, pulse width, amplitude, total charge, and energy delivered) is comparable to the levels applied by commercially available TENS stimulators. The sham control group will not receive any stimulation.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: taVNS
Description: The non-invasive transcutaneous auricular vagus nerve stimulation (taVNS) device that will be used in this study is a wearable TENS unit called the Vorso STIM100 System. The Vorso system consists of a wearable, external stimulator, a neural interface ear piece, and an arm band designed to be safe for human contact. The external stimulator generates electrical pulses that are transcutaneously delivered to the auricular branch of the vagus nerve through the ear canal. The ear piece contains 4 electrodes that carry current from the external stimulator to the auricular branch of vagus nerve. The external stimulator connects to a flexible arm band that attaches to the upper arm for ease of use during each stimulation session. The type of stimulation (including shape, frequency, pulse width, amplitude, total charge, and energy delivered) is comparable to the levels applied by commercially available TENS stimulators. The sham control group will not receive any stimulation.
Study: NCT06201533

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: combined physical-cognitive exercise
Description: A combined physical-cognitive exercise will be delivered in the form of exergame, where the participants move their body to interact with the game.
Study: NCT06317155

Intervention type: OTHER
Intervention: Occupational therapy
Description: Occupation Therapy, specifically interoception informed interventions which aim to improve sensory integration and emotional regulation. Additionally, occupational therapy models which focus on augmenting well-being and functionality, facilitating participation and engagement within communities, and promoting involvement in meaningful activity.

Intervention type: OTHER
Intervention: Occupational therapy
Description: Occupation Therapy, specifically interoception informed interventions which aim to improve sensory integration and emotional regulation. Additionally, occupational therapy models which focus on augmenting well-being and functionality, facilitating participation and engagement within communities, and promoting involvement in meaningful activity.

Intervention type: OTHER
Intervention: Occupational therapy
Description: Occupation Therapy, specifically interoception informed interventions which aim to improve sensory integration and emotional regulation. Additionally, occupational therapy models which focus on augmenting well-being and functionality, facilitating participation and engagement within communities, and promoting involvement in meaningful activity.
Study: NCT05461651

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Knee arthroplasty
Description: total or unilateral knee arthroplasty

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Knee arthroplasty
Description: total or unilateral knee arthroplasty
Study: NCT05844189

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Physical therapy modalities on pelvic floor (manual therapy)
Description: Intravaginal treatment (perineal massage)

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Physical therapy modalities on pelvic floor (manual therapy)
Description: Intravaginal treatment (perineal massage)
Study: NCT05162053

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vicagrel Capsules
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vicagrel Capsules
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vicagrel Capsules
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vicagrel Capsules
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vicagrel Capsules
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clopidogrel Tablets
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clopidogrel Tablets
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clopidogrel Tablets
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clopidogrel Tablets
Description: Oral administration for 7 days under fasting

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clopidogrel Tablets
Description: Oral administration for 7 days under fasting
Study: NCT05612360

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: COVID Booster text messages
Description: Participants will receive text messages per descriptions listed in the arms.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: COVID Booster text messages
Description: Participants will receive text messages per descriptions listed in the arms.
Study: NCT05207969

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Instruction to urinate
Description: Cystoscopy procedure will be done based on cystoscopy protocol. During scope procedure, patient will be ask to urinate and this will lead to contraction of urinary bladder and relaxation of external urethral sphincter. Scope will then pass through external urethral sphinter and go to the urinary bladder