TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05490628

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cognitive Rehabilitation
Description: Language, memory, attention and executive function exercises are performed for the participants' deficient cognitive functions.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conventional Therapy
Description: Strengthening, walking, balance and coordination exercises are performed according to the needs of the participants.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Therapy
Description: Strengthening, walking, balance and coordination exercises are performed according to the needs of the participants.
Study: NCT05906641

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: High-protein diet
Description: Protein intake will be increased to be 30% calories from protein with calcium caseinate.
Study: NCT06617390

Intervention type: OTHER
Intervention: No drug
Description: This is a non-interventional study and no study drug will be provided.

Intervention type: OTHER
Intervention: No drug
Description: This is a non-interventional study and no study drug will be provided.
Study: NCT06616233

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Remote Ischaemic Conditioning with exercise
Description: Participants will receive RIC through an automated device that will provide cycles on ischaemia/reperfusion to the target organ (arm). During the cuff deflation phase, participants will undergo handgrip exercise at 20-30% of their maximal voluntary contraction for 3 minutes. There will be a total of 4 cycles of exercise.

Intervention type: DEVICE
Group type: OTHER
Intervention: Other: Remote Ischaemic Conditioning
Description: Participants will receive RIC through an automated device that will provide cycles on ischaemia/reperfusion to the target organ (arm).. There will be a total of 4 cycles.
Study: NCT06617533

Intervention type: OTHER
Intervention: PCF model
Description: PCF practices practices receive (1) a per-beneficiary-per-month prospective payment that depends on the average health of their attributed Medicare beneficiaries; (2) a Flat Visit Fee for primary care visits, subject to a geographic adjustment factor, and (3) a Performance-based Adjustment (PBA). The PBAs depend on practices' performance on several quality measures in addition to their performance in reducing beneficiaries' use of inpatient care or total cost of care, relative to national and regional benchmarks. Practices must meet a limited set of care delivery requirements and can use the PCF Model's flexible use of payments to invest in strategies that best suit their practices' unique patient population and resources. In return, practices take on limited financial risk in exchange for performance-based payments that reward participants that meet certain performance and quality benchmarks for selected outcomes.
Study: NCT06616181

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Anodal tDCS over M1
Description: The anode will be placed over the left M1 (C3 according to the International 10-20 system), and the cathode will be positioned over the right supraorbital area (FP2). Once the electrodes are positioned, continuous stimulation at 2mA will be applied for 20 minutes per session, with 30-second initial and final ramp-ups. One session will be administered per week for 12 weeks.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Anodal tDCS over DLPFC
Description: The anode will be placed over the left dorsolateral prefrontal cortex (DLPFC) (C3 according to the International 10-20 system), and the cathode will be positioned over the right supraorbital area (FP2). Once the electrodes are positioned, continuous stimulation at 2mA will be applied for 20 minutes per session, with 30-second initial and final ramp-ups. One session will be administered per week for 12 weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise telerehabilitation
Description: Two weekly 50-minute sessions of mixed exercise, including both aerobic and resistance components, will be performed. Aerobic exercises will involve large muscle groups, and resistance training will be performed through elastic bands of varying intensity will be used for strengthening exercises. Exercise intensity will be regulated using the modified Borg Rating of Perceived Exertion scale (0-10), with participants maintaining between 4 and 7 points on this scale. The exercises will be monitored through video and weekly phone contact.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise telerehabilitation
Description: Two weekly 50-minute sessions of mixed exercise, including both aerobic and resistance components, will be performed. Aerobic exercises will involve large muscle groups, and resistance training will be performed through elastic bands of varying intensity will be used for strengthening exercises. Exercise intensity will be regulated using the modified Borg Rating of Perceived Exertion scale (0-10), with participants maintaining between 4 and 7 points on this scale. The exercises will be monitored through video and weekly phone contact.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Exercise telerehabilitation
Description: Two weekly 50-minute sessions of mixed exercise, including both aerobic and resistance components, will be performed. Aerobic exercises will involve large muscle groups, and resistance training will be performed through elastic bands of varying intensity will be used for strengthening exercises. Exercise intensity will be regulated using the modified Borg Rating of Perceived Exertion scale (0-10), with participants maintaining between 4 and 7 points on this scale. The exercises will be monitored through video and weekly phone contact.
Study: NCT05241119

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SLNB
Description: undergo fluorescence SLNB.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: pALND
Description: undergo low axillary lymph node dissection with ICBN as the boundary
Study: NCT06616701

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Follow up call
Description: As part of the standard of care, caregivers of youths who present to the hospital with suicidal risk receive a follow up call approximately 5-10 business days after the hospital discharge to assist them with any challenges they may encounter in accessing mental health care, including medication access. The intervention group will receive a call 5 days after discharge. The non-intervention group will receive a call 10 days after discharge.
Study: NCT05241119

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: ALND
Description: undergo ALND
Study: NCT06485427

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Selective Intra-arterial Cooling Infusion (IA-SCI)
Description: Pre-recanalization: During the procedure, the micro-catheter is advanced over a micro-guide wire, traveling up through the neck until it reaches beyond the clot. A 50 mL cold 0.9% saline (4 ℃) is infused intro into the ischemic territory at a rate of 10 mL/min via the micro-catheter. This enables the cold solution to infuse into the ischemic territory prior to revascularization.~Post-recanalization: After recanalization, cold 0.9% saline (4 ℃) is reinfused into the vessel via the catheter at a rate of 22 mL/min for 10 min, repeated twice with a 10-minute interval between infusions.
Study: NCT05379881

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Common Elements Toolbox (COMET)
Description: COMET is an unguided single-session intervention (SSI) combining elements of cognitive-behavioral therapy (CBT) and positive psychology.
Study: NCT05163418

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Foot orthosis for flat feet
Description: Plantar orthotics based on a unique process of footprinting, software design and orthotic printing to create custom 3D printed orthotics.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Foot orthoses for high arches feet
Description: Plantar orthotics based on a unique process of footprinting, software design and orthotic printing to create custom 3D printed orthotics.
Study: NCT05850130

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupuncture intervention
Description: 6 weeks of acupuncture once a week. The acupuncture intervention will consist of weekly session administered over a period of 6 weeks (± 4 days). A two-way verum acupuncture treatment protocol will employ 8 selected acupoints.~After week 7, patients included in Arm A may receive an optional 6 weeks of acupuncture. This option of acupuncture continuation will be left to the patient choice in agreement with a physician acupuncturist.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: No acupuncture
Description: The patient in the Arm B will not receive acupuncture treatment for a period of 6 weeks after randomization (weeks 1-6) and during the following weeks 8-13 (acupuncture intervention) if its NRS score is \<4/10 at week 7. If the patient' NRS score is ≥ 4/10 at week 7, the patient in control Arm B will receive the same acupuncture intervention that the patient in the Arm A (6 weeks).
Study: NCT06552533

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Resistance Exercises with Plyometric exercises
Description: We will apply protocol for 8 weeks 24 Sessions (3 sessions in a week) and 10 sec rest between each segment, 3 sets of 10 repetitions.~Resistive training will start in the form of manual resistive exercise for dorsiflexion, plantar flexion, eversion and inversion (manual resistance was applied for 3 to 5 seconds for ten repetitions in each cardinal plane).After resistance training the athletes will go for plyometric exercises and will follow the following guidelines.Tubing Exercises,Plyometric Ankle Jumps Ankle Circles
Study: NCT06617208

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Neuropixel probe recording
Description: Neuropixel recordings captures neuronal activity at the single-neuron level across the layers of the cortex.
Study: NCT06552533

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Resistance Exercises without Plyometric exercises
Description: We will apply protocol for 8 weeks 24 Sessions (3 sessions in a week) and 10 sec rest between each segment, 3 sets of 10 repetitions. Resistive training will start in the form of manual resistive exercise for dorsiflexion, plantar flexion, eversion and inversion (manual resistance was applied for 3 to 5 seconds for ten repetitions in each cardinal plane). While controlling the time that a maximal contraction will be maintained, the therapist will assure that the targeted musculature will being maximally loaded
Study: NCT05977933

Intervention type: DEVICE
Intervention: Shape II CPET
Description: Submaximal Cardiopulmonary exercise test equipment
Study: NCT04701294

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Giomer Beautifil flow plusF03 Shofu-Japan
Description: A pair of permanent first molars will be used for each participant homologs The operator will apply in the upper / lower first molars the sealant material in the order assigned according to the previous randomization. For the intervention group, they will be sealed based on a fluid resin with s-prg glass ionomer filling (Giomer F03 Beautiful -Shofu) in association with a bottle of adhesive (Single Bond) . The evaluation and monitoring process; another operator will record the retention of the sealant in a period of 6, 9 and 12 months.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Tetric N flow ivoclar vivadent-Germany
Description: And on the contralateral side (control) the first upper / lower molars will be sealed will be sealed with a fluid resin compound (Tetric N-Flow ivoclar vivadent) in association with a bottle of adhesive (Single Bond). Both materials have a similar color. The operator and the child will not be informed about the brand of the material used. The assistant will collect the data in the file. The evaluation and monitoring process; another operator will record the retention of the sealant in a period of 6, 9 and 12 months.
Study: NCT05649878

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Evaluation of bioavailability of methylprednisolone succinate administered intravenously
Description: Bioavailability of methylprednisolone in healthy subjects of both genders, when administered intravenously. The nominal doses were similar, volunteers were randomly assigned to receive a single dose of MEP by IV bolus of 1.5 mL. Venous blood samples were obtained via an indwelling catheter before administration and at 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 8, 12 and 24 h for DXM. Plasma was separated and frozen at -70 °C for further analysis.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Evaluation of bioavailability of methylprednisolone succinate administered intranasally
Description: Bioavailability of methylprednisolone in healthy subjects of both genders, when administered intranasally. Volunteers were randomly assigned to receive a single dose of MEP intranasally by using a Mucosal Atomization Device (MAD Nasal). allowing direct pharmacokinetic comparison without dose normalization. Venous blood samples were obtained via an indwelling catheter before administration and at 0.25, 0.5, 0.75, 1, 1.5, 2, 3, 4, 8, 12 and 24 h for DXM. Plasma was separated and frozen at -70 °C for further analysis.
Study: NCT04956224

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VLA2001
Description: whole virus inactivated SARS-CoV-2 vaccine adjuvanted with cytosine phospho-guanine (CpG) 1018 in combination with aluminium hydroxide (Wuhan strain)~2 vaccinations 28 days apart~Booster Vaccination on Visit B1
Study: NCT06367517

Intervention type: DRUG
Intervention: Tocilizumab
Description: Tocilizumab administrated at a dose of 8 mg/kg, given once every four weeks
Study: NCT06440824

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Romiplostim N01
Description: 2.0 µg/kg, subcutaneous injection, once a week, up to a maximum of 8 weeks. Stop medication when platelet count increases by 50 × 109/L or more compared to before medication

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Recombinant Human Thrombopoietin
Description: 30000 U/d, subcutaneously injected once a day, for a maximum of 8 weeks. Medication should be stopped when platelets increase by 50 × 109/L or more compared to before medication
Study: NCT05456386

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Circadian Rhythm Approach to Weight Loss (CRAWL)
Description: The Circadian Rhythm Approach to Weight Loss (CRAWL) is a behavioral intervention that is designed to provide support for behavioral change to improve sleep and feeding parameters that will lead to sustainable weight loss.
Study: NCT05158361

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupuncture
Description: Participants will receive acupuncture, three times per week for eight weeks. The selected acupoints include bilateral BL33, BL35, SP6, and ST36. All acupoints areas have been sterilized before acupuncture. For BL33, a needle (Ф0.40×100mm) will be inserted with an angle of 60° in an inferomedial direction at a depth of 90-100mm. For BL35, the same needle will be inserted with a direction to the ischial rectal fossa at a depth of 60-70 mm deep. For SP6 and ST36, needles (Ф0.30×50mm) will be directly inserted at a depth of 25-30 mm deep. After the needles are inserted, a portable electro-acupuncture machine will be connected to the handles of needles located in BL33 and BL35 to provide the electrical stimulation for 30 minutes with a disperse-dense wave (4/20Hz). All current intensities will be as high as can be tolerated.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham acupuncture
Description: The sham acupoints will be located at 20 mm outward to BL33, BL35, SP6, and ST36, and the needless will be inserted with a depth of 2 mm. The BL33 and BL35 will not receive any electrical stimulation, though the handles of needles will be connected to the same machine as the acupuncture group, and the parameter setting and course are also the same.
Study: NCT05998525

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dapagliflozin 10Mg Tab
Description: patients who meet the inclusion criteria and after catheterization will be randomized to receive Dapagliflozin 10 mg every 24 hours and upon dischargetreatment will continue for 12 months

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: patients who meet the inclusion criteria and after catheterization will be randomized to receive a placebo pill 24 hours and upon discharge treatment will continue for 12 months
Study: NCT06616220

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: administration of 0.5ml/kg of 0.2% ropivacaine with 0.1mg/kg Dexamethasone for the erector spine plane block

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: 0.9%NaCl
Description: 0.9% NaCl
Study: NCT05641792

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CGM (Dexcom G6)
Description: Dexcom G6 system consists of a transmitter and sensor that measure interstitial glycaemia every 5 minutes. Measurements are transmitted via Bluetooth to a compatible device, that uploads the data on a virtual drive. This allows for remote real-time glycaemia monitoring on another device.
Study: NCT06486636

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Left Posterior Pericardiotomy
Description: The surgeon will perform a left posterior pericardiotomy while the patient is on cardiopulmonary bypass. A soft channel drain will be put into place at an angle directed toward the posterior pericardium. The surgeon will grasp the pericardium and use cautery to make a 4- to 5-cm opening between the left inferior pulmonary vein and the diaphragm. The previously prepared channel drain is cut to the desired length and placed through the pericardiotomy along the diaphragm and into the pleural space.
Study: NCT06203730

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: dyadic psychological intervention strategy
Description: an intervention strategy for both patients and caregivers that combines psychotherapy techniques and health management
Study: NCT05647902

Intervention type: DIAGNOSTIC_TEST
Intervention: Serum samples will be collected. Asprosin levels will be determined by biochemical analysis
Description: Serum samples will be collected from both groups for biochemical analysis.

Intervention type: DIAGNOSTIC_TEST
Intervention: Serum samples will be collected. Asprosin levels will be determined by biochemical analysis
Description: Serum samples will be collected from both groups for biochemical analysis.
Study: NCT05100316

Intervention type: OTHER
Group type: OTHER
Intervention: Screening Platform
Description: Eligible participants who qualify as per this screening protocol may be referred to evaluate adoptive cell therapy in participants with various malignancies, on a separate treatment trial. No study treatment will be administered in this screening study.
Study: NCT05364879

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Prehabilitation Exercise Intervention
Description: The exercise intervention will consist of light-to-moderate intensity aerobic, resistance, and mobility exercises. These exercises will be performed in a circuit type manner. Participants will perform similar exercises that are modified to meet their individual abilities. Exercise intensity, modifications and substitutions will be determined for each participant based on their medical history, 6 minute walk test results, and baseline frailty scores. Exercise sessions will be performed 3x/wk beginning at 30 min and progressing to 60-min as tolerated for a minimum of four weeks but will continue up until the time of the participants surgery. A hybrid approach will be used for the exercise sessions whereby the participant must attend the first exercise session in person and subsequent sessions will be delivered virtually. Sessions will be overseen by the study Clinical Exercise Physiologist.
Study: NCT06615765

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupuncture
Description: Acupuncture sessions will use sterile, disposable stainless-steel needles (0.3 mm × 40 mm and 0.3 mm × 75 mm). Each session has two phases:~Supine Position:~* Needles (0.35 mm × 75 mm) are inserted into ST25, ST15, and SP14, reaching the abdominal muscle layer.~* Needles (0.30 mm × 40 mm) are inserted into CV12, CV4, ST36, ST37, and SP6.~* Electroacupuncture (EA) at ST25, SP15, and ST36 uses a continuous 5 Hz wave, 0.1 to 2.0 mA.~Prone Position:~* Needles are inserted into BL32, BL33, and BL35 with precise angles and depths.~* EA at BL32, BL33, and BL35 uses a continuous 5 Hz wave, 2.0 to 6.5 mA. Sessions occur three times a week for the first 4 weeks, then twice a week for weeks 5 to 8, each lasting 40 minutes, totaling 20 sessions.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham acupuncture
Description: Sterile, disposable stainless-steel needles (0.30 mm × 25 mm) will be used. After skin sterilization, needles will be inserted into the same points as the acupuncture group but to a shallow depth of 2 to 3 mm and lightly manipulated for blinding. Paired alligator clips will be attached to the same points, but the sham EA apparatus will have no current output, though it mimics the active EA apparatus in appearance and sound. Sham sessions will follow the same schedule as the acupuncture group: three times a week for the first 4 weeks and twice a week for weeks 5 to 8, each lasting 40 minutes, totaling 20 sessions.
Study: NCT06617091

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GRAdHIVNE1 Vaccine
Description: This is a dose ranging study that will allow for simultaneous enrollment of participants in both low and high dose groups.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: This is a dose ranging study that will allow for simultaneous enrollment of participants in both low and high dose groups.
Study: NCT06615700

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NA-931
Description: NA-931 is a quadruple receptor agonist for weight loss

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo of NA-931
Study: NCT06617078

Intervention type: PROCEDURE
Group type: OTHER
Intervention: long-term oxygen therapy (LTOT)
Description: Usual care with LTOT for 2 weeks

Intervention type: PROCEDURE
Group type: OTHER
Intervention: long-term oxygen therapy (LTOT)
Description: Usual care with LTOT for 2 weeks

Intervention type: PROCEDURE
Group type: OTHER
Intervention: High Flow Nasal Therapy (HFNT)
Description: High Flow Nasal delivered by myAirvo3 (4 hours minimum and during th 3-minute chair rise test, 30L/min, 34°C, identical O2 flow rate as LTOT) for 2 weeks

Intervention type: PROCEDURE
Group type: OTHER
Intervention: High Flow Nasal Therapy (HFNT)
Description: High Flow Nasal delivered by myAirvo3 (4 hours minimum and during th 3-minute chair rise test, 30L/min, 34°C, identical O2 flow rate as LTOT) for 2 weeks
Study: NCT06146855

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tunneling procedure with Amnion Membrane
Description: Root Coverage by tunneling procedure with the addition of Amnion Membrane as a soft tissue substitute
Study: NCT04742842

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: COVIGEN C19 0.8 mg ID or Placebo ID
Description: 2 doses of COVIGEN C19 0.8 mg ID or Placebo ID will be given at Day 1 and Day 29.
Study: NCT06289374

Intervention type: OTHER
Intervention: Biosample collection
Description: Collection of saliva, urine, blood, breath and quality of life questionnaires.