TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06215079

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: The Magstim Rapid2 Plus Magnetic Stimulator (Magstim, Whitland, Dyfed, UK)
Description: Transcranial Magnetic Stimulation (rTMS) is a non-invasive brain stimulation method that modulates the cortical excitability of the targeted motor area. While single-pulse TMS is generally used to explore the functioning of the brain, repetitive TMS is employed to induce lasting changes in brain activity. High-frequency rTMS leads to an increase in excitability in the motor cortex, whereas low-frequency application results in inhibition of motor cortical excitability. Theta-burst stimulation (TBS) is a form of rTMS that can be delivered continuously (cTBS) or intermittently (iTBS), thus modulating the excitability of corticospinal neurons beneath the stimulation area to either decrease or increase. rTMS is a growing research area in pain management, proven to be a safe and well-tolerated method. Studies have shown that rTMS applied to the motor cortex is a promising treatment method for chronic pain

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham transcranial magnetic stimulation
Description: Patients in the control group will receive sham transcranial magnetic stimulation with sham coil for 35 minutes a day, 5 sessions in total, together with conventional rehabilitation.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: conventional rehabilitation program
Description: Patients will receive 5 minutes of continuous ultrasound (1MHz, 2W/cm2, 1:4)), followed by a 20-minute contrast bath, and 15 minutes of TENS (frequency: 100 Hz; pulse duration: 50-100 ms; and amplitude adjusted to avoid discomfort or muscle contraction to the patient).
Study: NCT05301478

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: 3D Printed Insole - FEA
Description: 3D Printed Insole - FEA
Study: NCT06138860

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: strain counter strain technique
Description: It will be done in accordance with the technique principles in which the therapist will locate trigger point, and then find a position of comfort or mobile point (at least a 70% decrease in tenderness),monitored the tender point, holding the position o f comfort for 90 seconds, It will be conducted three times per session, for twelve sessions three times per week every other day over the course of a month.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: physical therapy exercises
Description: Physical therapy exercises for twelve sessions, three times a week, over the course of a month.~Exercises will include:~stretching exercises for the hamstring, calf muscles, and back muscles.~strengthening exercises for back muscles and abdominal muscles.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: physical therapy exercises
Description: Physical therapy exercises for twelve sessions, three times a week, over the course of a month.~Exercises will include:~stretching exercises for the hamstring, calf muscles, and back muscles.~strengthening exercises for back muscles and abdominal muscles.
Study: NCT04473742

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Blood collection
Description: 4 EDTA tubes for 24 mL blood collection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood collection
Description: 4 EDTA tubes for 24 mL blood collection

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Blood sample
Description: 2 drying tubes for 12 mL blood collection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood sample
Description: 1 drying tube for 6 mL blood collection
Study: NCT05111301

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Control-IQ technology 1.5
Description: All subjects wearing the t-slim X2 insulin pump with Control-IQ technology 1.5, and wearing the Dexcom G6 sensor.~Outcomes will be analyzed overall and subgroup analysis will be performed by Group, and by baseline A1c level.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Control-IQ technology 1.5
Description: All subjects wearing the t-slim X2 insulin pump with Control-IQ technology 1.5, and wearing the Dexcom G6 sensor.~Outcomes will be analyzed overall and subgroup analysis will be performed by Group, and by baseline A1c level.
Study: NCT04951661

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Virtual Reality
Description: Participants will be set up in the VR equipment. They will engage and follow along with a 10-20 minute guided meditation through the VR. The meditation program may include simulated movement, relaxing music, and the voice of a meditation guide. The research team member will supervise the session, ensuring safety of the subject is maintained.
Study: NCT04838977

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: RESET
Description: Therapy
Study: NCT05344404

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nicotinamide Riboside
Description: 3000mg total daily. Administered in capsule form in doses of 1500mg twice daily for the duration of the trial (4 weeks).

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo drug. Administered in tablet form twice daily for the duration of the trial (4 weeks).
Study: NCT05317325

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: OCDC vaccine; NeoDC vaccine
Description: OCDC vaccine and NeoDC vaccine are administered in a prime-boost regimen by subcutaneous injection.
Study: NCT05751018

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pyrotinib
Description: Pyrotinib maleate is a small molecule tyrosine kinase inhibitor that can irreversibly inhibit HER1, HER2, and HER4.
Study: NCT04882397

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Instrument Assisted Soft Tissue Mobilization
Description: Bilateral Instrument assisted soft tissue mobilization application will be applied in a single session to the trapezius and sternocleideomastoideus muscles.
Study: NCT05282602

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: baseline physical therapy treatment along with Wii Fit based exercises
Description: Group A performed Wii Fit based exercises for 6 weeks. Group A will be treated with Wii Fit based exercises (40 mins session, 3 days/week, Penguin slide, soccer heading, tilt table, tightrope walking)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Proprioceptive exercises
Description: Group B will be treated with Proprioceptive training (40 min session, 3 days/week, toe walking, heel walking, cross-body leg swings right and left sides, partial squat, ). In both groups pre and post-test measurements of Balance and Fall of risk will be assessed through Berg Balance scale, STAR excursion, Modified Fall Efficacy scale, and Timed Up and Go (TUG). Evaluation will be done before session start and at the end of 6th Week.
Study: NCT05089422

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Squint surgery
Description: Lateral rectus recession and /or medial rectus resection
Study: NCT06055543

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Fortimel
Description: 2 bottles/day of the high energy ONS

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Fortimel
Description: 2 bottles/day of the high energy ONS
Study: NCT06044051

Intervention type: OTHER
Group type: OTHER
Intervention: Blood sample
Description: An additionnal volume of blood will be collected at inclusion and at each follow-up visit

Intervention type: OTHER
Group type: OTHER
Intervention: Expectoration
Description: Expectoration will be collected at inclusion and at each follow-up visit

Intervention type: OTHER
Group type: OTHER
Intervention: Nasopharyngeal swab
Description: A nasopharyngeal swab will be collected at inclusion and at each follow-up visit after an induced sputum
Study: NCT06111118

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ThermaCare HeatWraps
Description: ThermaCare HeatWraps application

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ThermaCare HeatWraps
Description: ThermaCare HeatWraps application
Study: NCT06151080

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide combined with G-CHOP (LO CHOP)
Description: Lenalidomide combined with G-CHOP to treat newly diagnosed diffuse large B-cell lymphoma with follicular lymphoma (CDLBCL-FL)
Study: NCT04882397

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham
Description: Bilateral sham Instrument assisted soft tissue mobilization application will be applied in a single session to the trapezius and sternocleideomastoideus muscles.
Study: NCT05798260

Intervention type: DIAGNOSTIC_TEST
Intervention: Agilent Seahorse XF Cell Mito Stress Test
Description: The Agilent Seahorse XF Cell Mito Stress Test measures key parameters of mitochondrial function by directly measuring the oxygen consumption rate (OCR) of cells on the Seahorse XFe and XF Extracellular Flux Analyzers. It is a plate-based live cell assay that allows to monitor spare respiratory capacity (SRC), basal respiration, ATP production-coupled respiration, maximal respiration, and non-mitochondrial respiration in real time before and after ketone monoester

Intervention type: DIAGNOSTIC_TEST
Intervention: Agilent Seahorse XF Cell Mito Stress Test
Description: The Agilent Seahorse XF Cell Mito Stress Test measures key parameters of mitochondrial function by directly measuring the oxygen consumption rate (OCR) of cells on the Seahorse XFe and XF Extracellular Flux Analyzers. It is a plate-based live cell assay that allows to monitor spare respiratory capacity (SRC), basal respiration, ATP production-coupled respiration, maximal respiration, and non-mitochondrial respiration in real time before and after ketone monoester
Study: NCT05854901

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Procalcitonin
Description: blood test, measuring the concentration of PCT in ug/L

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Physician's decision
Description: The physician's decided whether the patient will receive antibiotic treatment or not
Study: NCT05035602

Intervention type: OTHER
Intervention: Physical activity assessment
Description: Physical activity patterns will be obtained from google location history, using an Android phone

Intervention type: OTHER
Intervention: Physical activity assessment
Description: Physical activity patterns will be obtained from google location history, using an Android phone

Intervention type: OTHER
Intervention: Physical activity assessment
Description: Physical activity patterns will be obtained from google location history, using an Android phone
Study: NCT05863000

Intervention type: OTHER
Intervention: Online questionnaire/survey
Description: Participants are expected to answer a short survey based on their overall experiences with their own health. No participants will therefore be followed for more than the duration of time it takes a subject to answer the questionnaire (approx 15 minutes). Randomly selected volunteers of around 30 respondents will afterwards be invited to participate in a qualitative interview with the intend to elaborate their questionnaire responds.
Study: NCT05831683

Intervention type: OTHER
Intervention: Introduction of Standard Operating Procedure regarding lung protective ventilation during general anaesthesia.
Description: The Standard Operating Procedure document will be introduced. The SOP document will cover the theoretical background, definition, and recommendations/criteria of LPV. The SOP document will reflect the most recent LPV guidelines.
Study: NCT00910156

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Airtraq laryngoscope
Description: Airtraq intubation

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Glidescope laryngoscope
Description: glidescope intubation

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Macintosh laryngoscope
Description: Macintosh intubation
Study: NCT05744739

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tomivosertib
Description: Given PO
Study: NCT05713149

Intervention type: OTHER
Intervention: Surgical flap and anti-bacterial agents
Description: Surgical flap and anti-bacterial agents
Study: NCT05787548

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Contact information
Description: Information on how to contact Geisinger if the patient needs care

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Contact information
Description: Information on how to contact Geisinger if the patient needs care

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Contact information
Description: Information on how to contact Geisinger if the patient needs care

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Urgent care map
Description: A map of the patient's nearest Geisinger urgent care location, with information about urgent care

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Urgent care map
Description: A map of the patient's nearest Geisinger urgent care location, with information about urgent care

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self-triage chart
Description: A chart demonstrating what to do in response to several common conditions where the patient might be compelled to visit the ED
Study: NCT05693012

Intervention type: DIAGNOSTIC_TEST
Intervention: cfDNA methylation assessment
Description: An exploratory study to establish the early detection and prognosis models of multiple myeloma patients in China based on plasma cf DNA methylation assessment

Intervention type: DIAGNOSTIC_TEST
Intervention: cfDNA methylation assessment
Description: An exploratory study to establish the early detection and prognosis models of multiple myeloma patients in China based on plasma cf DNA methylation assessment

Intervention type: DIAGNOSTIC_TEST
Intervention: cfDNA methylation assessment
Description: An exploratory study to establish the early detection and prognosis models of multiple myeloma patients in China based on plasma cf DNA methylation assessment
Study: NCT05637528

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: Patients will undergo an MRI and mammography one year after MagTrace injections
Study: NCT05140720

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PNEUMOSIL®
Description: Study subjects will be vaccinated PNEUMOSIL® with the primary doses as described below:~Group 1: 3 doses, 4 to 8 week interval Group 2: 2 doses, dose interval \> 1 month Group 3: 2 doses, dose interval \> 2 months

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PNEUMOSIL®
Description: Study subjects will be vaccinated PNEUMOSIL® with the primary doses as described below:~Group 1: 3 doses, 4 to 8 week interval Group 2: 2 doses, dose interval \> 1 month Group 3: 2 doses, dose interval \> 2 months

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PNEUMOSIL®
Description: Study subjects will be vaccinated PNEUMOSIL® with the primary doses as described below:~Group 1: 3 doses, 4 to 8 week interval Group 2: 2 doses, dose interval \> 1 month Group 3: 2 doses, dose interval \> 2 months
Study: NCT06225479

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: An individualized 12-week exercise intervention that will follow American College of Sports Medicine guidelines to ensure a gradual safe increase in frequency and intensity. The exercise goals for participants in the intervention arm are to increase minutes/week of aerobic exercise, build strength and muscle mass, and improve flexibility, core strength, and balance progressively over the course of 12 weeks. The participants are prescribed 3 sessions of aerobic exercise lasting 45-75 minutes each, including warm up and cool down; 2 resistance training sessions per week, and at least 3 flexibility and balance sessions per week.~Intervention arm receives the following: Control arm Successful Aging newsletter plus additional educational materials related to exercise, heart rate monitor and resistance bands, and two 90-minute sessions and ten 30-minute phone sessions over 12 weeks with an exercise coach (the first two sessions include a resistance training session).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Calls and Newsletter
Description: A 12-week remote health education program developed by the study team to provide a control for the exercise intervention. Participants in this arm will receive a summary of the American College of Sports Medicine guidelines (self-directed and time-based), a twice-monthly Successful Aging newsletter with suggestions for health diet, stress reduction, and social engagement, and twice-monthly phone calls to reinforce and discuss topics in the newsletter and to review adverse events and change in medications.
Study: NCT06227793

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: pharmaceutical intervention
Description: Individuals randomized to the intervention group will undergo monthly pharmaceutical consultations for health education, initiated after randomization. There will be three in-person consultations, starting in month 1 with monthly spacing, scheduled by the pharmacist in the office, except for the first consultation, which will be scheduled by the pharmacist over the phone after randomization. These consultations will be part of the intervention study's educational process and will take place between the initial and final assessments. The educational process scripts for each consultation include a pharmaceutical follow-up form and an inhalation technique assessment form. Once the consultation is completed, the patient will also receive, via WhatsApp and/or email according to their preference, an educational video demonstrating the step-by-step inhalation technique based on their prescribed treatment.
Study: NCT06384118

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Impact of an IMB theory-based health education intervention on hypoglycemic coping in patients with type 2 diabetes: a pilot study
Description: Based on IMB health education theory Questionnaire collection, face-to-face interview, and manual interpretation on the first day of admission; questionnaire collection, face-to-face interview, and manual interpretation on the first day of admission; hypoglycemia knowledge promotion on the second day; Peer experience sharing on the third day; access to WeChat group and knowledge pushing on the fourth day; hypoglycemia-related lectures and practical teaching on the fifth day, face-to-face teaching and development of blood glucose management plan. Hypoglycemia knowledge contest on the day before discharge; One week, two weeks and three weeks after discharge for WeChat push or phone call; WeChat push, phone call and questionnaire.
Study: NCT05904418

Intervention type: OTHER
Group type: OTHER
Intervention: Robot-assisted US Scan of the vertebra L1 to S1
Description: A standardized robot-assisted US-Scan of the vertebra L1 to the S1 is executed. The two probe trajectories are generated automatically by an optical camera or RedGreenBlue-Depth (RGB-D) camera. Then the robot will scan at two mm/s, automatically following the trajectory. A 6 degrees of freedom (DoF) force sensor (Nano25, Ati Industrial Automation Inc.) was assembled at the US probe. During the scanning, it measures the interaction force and torque between the US probe and volunteers' skin to ensure volunteer safety. The US images and corresponding robot poses are recorded for the reconstruction. A previously developed algorithm is used to obtain a preliminary 3D reconstruction that will be used to adapt the scanning pattern in case of incomplete scanning.

Intervention type: OTHER
Group type: OTHER
Intervention: Handheld US scan of the vertebra L1 to S1
Description: A handheld US-Scan of the vertebra L1 to S1 is executed. An optical marker for an Atracsys Camera is mounted to the US probe to track its position. Simultaneously, the optical tracking allows for standardization of the US-Scan through navigation. The acquired US images and corresponding poses are used to reconstruct the lumbar spines and compared to the ground truth (CT scan). Handheld US scanning will be performed at around two mm/s in two scanning trajectories. The US probe orientation will be adjusted during the scanning by comparing the optical marker orientation with the initial probe orientation. This combination leads to different scanning patterns. For each pattern, the scanning procedure will be repeated three times. At least once per volunteer, each handheld scanning pattern will be performed with a higher manual speed to assess the reconstruction quality with faster scanning. A graphical user interface (GUI) will synchronize and store the data during the scanning.

Intervention type: RADIATION
Group type: OTHER
Intervention: ULD CT scan of the vertebra L1 to S1
Description: A ULD CT scan (CT, Siemens Naeotom Alpha: A-207883-62) of the lumbar spine (L1-S1) is performed at the Swiss Center for Musculoskeletal Imaging (SCMI) at Balgrist Campus, Zurich. The total duration estimate for the CT examination is 30 minutes, whereas the scan takes 15 minutes. The volunteers lie on their abdomen during this procedure to simulate the spine's position during the subsequent US examination. The vertebrae (L1-S1) in the CT Scans are manually segmented with global thresholding and the region growing tool in a standard segmentation software (Materialise Mimics, Leuven, Belgium). The 3D surface models are then exported as Standard Triangle Language (STL) files.
Study: NCT05171062

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: bexmarilimab (FP-1305)
Description: standard 3+3 dose escalation trial of bexmarilimab (FP-1305)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: bexmarilimab (FP-1305)
Description: standard 3+3 dose escalation trial of bexmarilimab (FP-1305)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: bexmarilimab (FP-1305)
Description: standard 3+3 dose escalation trial of bexmarilimab (FP-1305)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: bexmarilimab (FP-1305)
Description: standard 3+3 dose escalation trial of bexmarilimab (FP-1305)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Pembrolizumab 200mg IV is administered in 4 planned bexmarilimab dose escalation cohorts

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Pembrolizumab 200mg IV is administered in 4 planned bexmarilimab dose escalation cohorts

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Pembrolizumab 200mg IV is administered in 4 planned bexmarilimab dose escalation cohorts

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Pembrolizumab 200mg IV is administered in 4 planned bexmarilimab dose escalation cohorts
Study: NCT04820140

Intervention type: PROCEDURE
Intervention: Lymphatic drainage
Description: Lymphatic drainage