Study: NCT05322538

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: vitamin D plasma levels baseline
Description: Measuring vitamin D plasma levels at baseline

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: vitamin D plasma levels baseline
Description: Measuring vitamin D plasma levels at baseline

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Dual-energy X-ray absorptiometry at baseline
Description: Measuring T-score and Z-score of the femur and lumbar spine at baseline

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Dual-energy X-ray absorptiometry at baseline
Description: Measuring T-score and Z-score of the femur and lumbar spine at baseline

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: cervical Vestibular evoked myogenic potentials at baseline
Description: cVEMP is a vestibular test for saccular function, an otolith organ in the inner ear. the electrical response of the stermocledomastoid muscle to saccular stimulation is measured via two distinct waves - P13 and N23. the latency, amplitude and peak to peak amplitude will be measured.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Audiogram at baseline
Description: hearing measurement will be performed. Hearing level in dB will be performed in the 250-8,000 Hz frequency. The test includes Speech reception threshold and word recognition score.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Measuring Orthostatic Blood Pressure at baseline
Description: blood pressure will be measure two minutes after lying supine and repeated 3 minutes after standing. A drop of at least 20mmHg systolic pressure or at least 10mmHg diastolic blood pressure is considered a positive test

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Measuring Orthostatic Blood Pressure at baseline
Description: blood pressure will be measure two minutes after lying supine and repeated 3 minutes after standing. A drop of at least 20mmHg systolic pressure or at least 10mmHg diastolic blood pressure is considered a positive test

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: cold pressor test at baseline
Description: The cold pressor test is an indicator for sympathetic system function. A rise of at least 15mmHg of systolic pressure after putting the subject's hand in cold water (4 deg Celsius) is indicative of normal sympathetic function.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: cold pressor test at baseline
Description: The cold pressor test is an indicator for sympathetic system function. A rise of at least 15mmHg of systolic pressure after putting the subject's hand in cold water (4 deg Celsius) is indicative of normal sympathetic function.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: vitamin D plasma levels one year after recruitment
Description: Measuring vitamin D plasma levels one year after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: vitamin D plasma levels two years after recruitment
Description: Measuring vitamin D plasma levels two years after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Dual-energy X-ray absorptiometry one year after recruitment
Description: Measuring T-score and Z-score of the femur and lumbar spine one year after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Dual-energy X-ray absorptiometry two years after recruitment
Description: Measuring T-score and Z-score of the femur and lumbar spine two years after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: cervical Vestibular evoked myogenic potentials one year after recruitment
Description: cVEMP is a vestibular test for saccular function, an otolith organ in the inner ear. the electrical response of the stermocledomastoid muscle to saccular stimulation is measured via two distinct waves - P13 and N23. the latency, amplitude and peak to peak amplitude will be measured one year after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: cervical Vestibular evoked myogenic potentials two years after recruitment
Description: cVEMP is a vestibular test for saccular function, an otolith organ in the inner ear. the electrical response of the stermocledomastoid muscle to saccular stimulation is measured via two distinct waves - P13 and N23. the latency, amplitude and peak to peak amplitude will be measured two years after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Audiogram one year after recruitment
Description: hearing measurement will be performed. Hearing level in dB will be performed in the 250-8,000 Hz frequency. The test includes Speech reception threshold and word recognition score performed one year after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Audiogram two years after recruitment
Description: hearing measurement will be performed. Hearing level in dB will be performed in the 250-8,000 Hz frequency. The test includes Speech reception threshold and word recognition score performed two years after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Measuring Orthostatic Blood Pressure one year after recruitment
Description: blood pressure will be measure two minutes after lying supine and repeated 3 minutes after standing. A drop of at least 20mmHg systolic pressure or at least 10mmHg diastolic blood pressure is considered a positive test. The test will be performed one year after recruitment

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Measuring Orthostatic Blood Pressure two years after recruitment
Description: blood pressure will be measure two minutes after lying supine and repeated 3 minutes after standing. A drop of at least 20mmHg systolic pressure or at least 10mmHg diastolic blood pressure is considered a positive test. The test will be performed two year after recruitment.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: cold pressor test one year after recruitment
Description: The cold pressor test is an indicator for sympathetic system function. A rise of at least 15mmHg of systolic pressure after putting the subject's hand in cold water (4 deg Celsius) is indicative of normal sympathetic function. The test will be performed one year after recruitment.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: cold pressor test two years after recruitment
Description: The cold pressor test is an indicator for sympathetic system function. A rise of at least 15mmHg of systolic pressure after putting the subject's hand in cold water (4 deg Celsius) is indicative of normal sympathetic function. The test will be performed two years after recruitment.