TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05492500

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Main cohort (Cohort A): Ponsegromab low dose
Description: Ponsegromab low dose subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Main cohort (Cohort A): Ponsegromab medium dose
Description: Ponsegromab medium dose subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Main cohort (Cohort A): ponsegromab high dose
Description: Ponsegromab high dose subcutaneous injection

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Main cohort (Cohort A): Matched placebo
Description: Matched placebo subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Open-label, PK Cohort (Cohort B): ponsegromab low dose
Description: ponsegromab low dose subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Open-label, PK Cohort (Cohort B): ponsegromab medium dose
Description: Ponsegromab medium dose subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Open-label, PK Cohort (Cohort B): ponsegromab high dose
Description: Ponsegromab high dose subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Optional Cohort C: Ponsegromab low dose
Description: Ponsegromab low dose subcutaneous injection

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Optional Cohort C: Matched placebo
Description: Matched placebo subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Optional Cohort D: Ponsegromab high dose
Description: Ponsegromab high dose subcutaneous injection

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Optional Cohort D: Matched placebo
Description: Matched placebo subcutaneous injection
Study: NCT06572241

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Intrathecal morphine
Description: morphine 100 mcg, included in the intrathecal component of combined spinal epidural (CSE).

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Saline solution (placebo)
Description: normal saline 0.2 ml added to the intrathecal component of combined spinal epidural (CSE).
Study: NCT04385732

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: 2D or 3D Melanoma Surveillance Photography
Description: Total body imaging using 2D or 3D Melanoma Surveillance Photography plus digital dermoscopy.
Study: NCT05890677

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgical Intervention
Description: LVA (Lymphovenous Anastomosis) and VLNT (Vascularised Lymph Node Transfer) are two advanced microsurgical techniques that are increasingly implemented in clinical practice in specialized centers and that are already carried out after health insurance application according to local standard of care. They have been studied in their respective mode of action as well as in their effectiveness in treating chronic BCRL (Breast Cancer-Related Lymphedema) in a multitude of mostly observational and single center studies with highly encouraging results. Patients in the interventional arm A will receive surgery with one of the two approaches or a combination of both, in a one or two-stage method, at the discretion of the treating surgeon. Depending on local standards one or both of the above might be combined with liposuction to the affected arm in a one or two-stage approach as well.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Conservative Complex Physical Decongestion Therapy
Description: Patients randomized to the control arm will receive CDT (Conservative Complex Physical Decongestion Therapy), which currently is considered as the best available standard of care. For this, patients will be referred to one of the dedicated LE (physical/skin) therapy clinics, if not already treated by one, according to their place of residence for continuation of standard conservative therapy. Recommendations to the procedures and treatment frequency of the conservative therapy will be made, but CDT will be done at the discretion of the treating physiotherapist.
Study: NCT04309812

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: transcranial direct current stimulation (tDCS)
Description: Electrical stimulation of scalp over a seizure focus

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: transcranial direct current stimulation (tDCS)
Description: Electrical stimulation of scalp over a seizure focus
Study: NCT05532475

Intervention type: DIAGNOSTIC_TEST
Intervention: measurement of vitreous level of tumor necrosis factor alpha
Description: measurement of vitreous level of tumor necrosis factor alpha using ELISA technique

Intervention type: DIAGNOSTIC_TEST
Intervention: measurement of vitreous level of tumor necrosis factor alpha
Description: measurement of vitreous level of tumor necrosis factor alpha using ELISA technique
Study: NCT05672524

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab
Description: Patients will then be given tucatinib (300 mg BID orally) and trastuzumab (8 mg/kg on day 1, then 6 mg/kg starting cycle 2 and every three weeks) therapy for an initial 6 week lead-in period. All patients, regardless of findings on rectal MRI will then transition to standard of care induction chemotherapy with continuation of the trastuzumab and tucatinib for a total of five additional cycles (15 extra weeks).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tucatinib
Description: Patients will then be given tucatinib (300 mg BID orally) and trastuzumab (8 mg/kg on day 1, then 6 mg/kg starting cycle 2 and every three weeks) therapy for an initial 6 week lead-in period. All patients, regardless of findings on rectal MRI will then transition to standard of care induction chemotherapy with continuation of the trastuzumab and tucatinib for a total of five additional cycles (15 extra weeks).
Study: NCT06479876

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: HBCR
Description: Home-based cardiac rehabilitation intervention facilitated by a custom app to deliver education, counseling on healthy living and modification of risk factors, mindfulness, and physical activity guidance. Additionally, there are periodic video calls with an exercise physiologist.
Study: NCT06071468

Intervention type: DEVICE
Intervention: UltraGuideCTR (Device) with Ultrasound Guided Carpal Tunnel Release (CTR-US)
Description: The UltraGuideCTR is a commercially available medical device specifically developed to facilitate CTR-US. The device is a single-use, hand-held device that is inserted into the carpal tunnel through a small (typically \< 5 mm) wrist incision using continuous US guidance. The working tip of the UltraGuideCTR consists of two inflatable balloons that border a centrally located, retractable retrograde cutting knife. When inflated with sterile saline, the balloons increase the diameter of the tip from 4 mm to 8 mm. After the tip is positioned within the transverse safe zone of the carpal tunnel, the balloons are inflated to create space in the carpal tunnel, the blade is activated, and the TCL is transected in a retrograde manner. Following TCL transection, the blade is recessed, the balloons deflated, and the device is removed. The TCL is probed to ensure a complete release. The entire procedure is performed using US guidance.
Study: NCT04597008

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treatment group
Description: Standard of Care + Local Vancomycin + Local Tobramycin: Participants in the treatment group will receive a dose of 1000mg of Vancomycin powder AND a dose of 1200mg of Tobramycin powder in their wound bed immediately before wound closure.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Control group
Description: Standard of Care + Local Vancomycin: Participants in the control group will receive a dose of 1000mg of Vancomycin powder in their wound bed immediately before wound closure.
Study: NCT06071468

Intervention type: PROCEDURE
Intervention: Endocscopic CTR
Description: Endoscopic CTR makes one or two short incisions to introduce instruments for visualizing. The key procedural steps involved in Endoscopic CTR are listed below.~1. Following the delivery of anesthesia, the surgeon makes a small wrist incision (usually less than 1.5 cm), with or without a small palmar incision (usually less than 1.5 cm, depending on whether they are using a single portal or double portal technique, respectively.~2. A series of dilators and raspers are used to create space in the carpal tunnel and clear synovial tissue from the undersurface fo the TCL.~3. A camera attached to a narrow tube (endoscope) is inserted into the carpal tunnel.~4. The transverse carpal ligament (which forms the roof of the carpal tunnel) is identified.~5. Using specialized cutting instruments and endoscopic guidance, the surgeon transects the TCL.~6. Endoscopic visualization and/or probing are used to confirm a complete release.~7. The wound(s) is/are typically closed with sutures.

Intervention type: PROCEDURE
Intervention: Open CTR
Description: OCTR is the most commonly used CTR technique in the United States.The key procedural steps involved in OCTR are listed below.~1. Following the delivery of anesthesia, an incision is made in the palm directly over the carpal tunnel.~2. The surgeon cuts through the palmar fascia to identify the TCL.~3. The surgeon transects the TCL with a scalpel and/or similar cutting instruments.~4. The surgeon inspects the carpal tunnel to ensure proper decompression.~5. The wound is closed with sutures.
Study: NCT06089473

Intervention type: OTHER
Group type: OTHER
Intervention: Intervention Group: Exercise and education.
Description: * Exercise Intervention: 12-weeks of supervised, individualized virtual exercise sessions, delivered by an accredited kinesiologist. Independent unsupervised sessions start at week 5. After 12 weeks, a 5-month maintenance phase is followed, continuing to exercise three times weekly for 30 minutes per session.~* Education: Prior to each zoom session with the kinesiologist (starting on week 2), participants will watch short educational videos. Additionally, participants will be provided a document (PDF) of evidence-based strategies to help cope with stress.

Intervention type: OTHER
Group type: OTHER
Intervention: Usual Care Only
Description: Usual Care for kidney transplant candidates, which may include medical visits, nutrition, and psychological support.
Study: NCT06089291

Intervention type: DEVICE
Intervention: Persona IQ
Description: Persona IQ is a system comprised of the following subsystems:~1. RTM utilizing mymobility® patient application and care team dashboard,~2. PPK System with~3. CTE Extension Implant and Instrumentation,~   1. Surgical Base Station System,~  2. Home Base Station System,~  3. Canary CDMP,~  4. Canary CMGP software module, and~4. The ZBEdgeTM Connected Artificial Intelligence data platform.~The system combines physical components, electronics, software, and user interfaces to collect, store, analyze, transmit, and display patient data for use by both physicians and patients.
Study: NCT05738096

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: TSEP + rhizotomy surgery
Description: TGN patients recruited for this study will already be undergoing percutaneous rhizotomy surgery. TSEPs will be measured at baseline prior to surgery. During the rhizotomy procedure, an electrode or balloon is placed through a metal sheath to then damage the nerve. A stylet is introduced to clear tissue from the sheath in preparation for the electrode or balloon. Prior to the final insertion of the RF electrode where the gasserian ganglion will be damaged, we will place a standard stereotactic EEG electrode (SEEG). Following damaging the nerve (clinical procedure), we will record again to measure differences in the TSEPs following cell body damage. The Neuralynx system will be used to record the potentials at 40 KHz.
Study: NCT06016153

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Software based feedback
Description: Feedback is given by the data of a software (InnoMed CardioAid-1 Trainer AED, Innomed Inc., Budapest, Hungary).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Instructor feedback
Description: Feedback is given by the opinion and observation of an experienced instructor.
Study: NCT06662357

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Behavioral Treatment
Description: Family Connections Care Planning Team: Clinical expertise will be combined with peer-to-peer parent/guardian support for trauma-informed care delivery to both parent and child. All aspects of the care continuum will be provided in a culturally and linguistically competent manner, with child and family-driven care planning.
Study: NCT06665724

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 5-Aminolevulinic acid Hydrochloride (Gliolan®)
Description: Patients will receive 5-Aminolevulinic acid hydrochloride via oral administration (20 mg/kg) 6-8 hours before CV01 treatment.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CV01
Description: Ultrasound will be delivered 6-8 hours after administration of 5-aminolevulinic acid hydrochloride. A total of 12 fields will be treated (10 treatment sites across the hemisphere with 2 additional treatments over areas of increased enhancement).
Study: NCT06248515

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sacituzumab govitecan-hziy
Description: 10 mg/kg once weekly on Days 1 and 8 of continuous 21-day treatment cycles
Study: NCT06542380

Intervention type: DEVICE
Intervention: TAVI, pacemaker
Description: Retrospective analysis of need for pacemaker implantation after TAVI
Study: NCT06668155

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Autograft Group
Description: If assigned the autograft group, the surgeon will choose either bone patella tendon bone (BPTB) or all soft tissue quadriceps tendon for the graft. The graft choice will be based upon surgeon preference.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Allograft with LET Group
Description: The allograft used will be a non-irradiated quadriceps tendon with bone plug allograft with a donor age less than 45 years.
Study: NCT05339425

Intervention type: OTHER
Intervention: No additional intervention will be administered.
Description: No additional intervention will be administered.
Study: NCT06569641

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Neoneur Feeding System
Description: The Neoneur Feeding System is placed between a nipple and a bottle, and used to measure feeding skill patterns.
Study: NCT05053113

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Activity Monitor
Description: Monitor physical activity with FitBit

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Activity Monitor
Description: Monitor physical activity with FitBit

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Activity Monitor
Description: Monitor physical activity with FitBit

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Activity Monitor
Description: Wear accelerometer

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Activity Monitor
Description: Wear accelerometer

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Activity Monitor
Description: Wear accelerometer

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Educational Intervention
Description: Receive educational newsletter

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Educational Intervention
Description: Receive educational newsletter

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Educational Intervention
Description: Receive educational newsletter

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Survey Administration
Description: Ancillary studies

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Survey Administration
Description: Ancillary studies

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Survey Administration
Description: Ancillary studies

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Telephone-Based Intervention
Description: Receive phone call from health coach

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Telephone-Based Intervention
Description: Receive phone call from health coach
Study: NCT06569628

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Envita Stories Methodology in Long-term care Centres for old adults
Description: Collaborative intervention program in long-term care Centres for old adults between professionals, old adults, families and volunteers that aims to foster person-centered care and promote meaningful relationships through the digitization of life stories and life project methodologies in a timeline.
Study: NCT06602102

Intervention type: DEVICE
Intervention: Mixed reality Glasses
Description: Mixed reality glasses are devices that combine elements of augmented reality and virtual reality. They allow users to overlay digital images onto the real world, enabling interaction with virtual objects in a physical environment. These glasses typically use sensors, cameras, and tracking technology to map the surroundings and provide an immersive experience. They are used in various applications, such as gaming, education, design, and professional training.
Study: NCT06679348

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: walking exercise on treadmill
Description: The study included two intervention groups, consisting of participants who met the inclusion criteria and adhered to the experimental procedures. One group will do treadmill walking exercises, while the other will do treadmill walking exercises using virtual reality (VR). Both interventions were conducted in a single session, with each group participating in a 20-minute walking exercise session at a moderate intensity, as identified by other studies.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treadmill walking exercise using VR
Description: Walking on the treadmill with the Free Run game on the Nintendo Wii allows users to walk at 5 miles per hour for 20 minutes. The user gets on the Wii Balance Board and starts walking in the virtual environment after running the application. The application detects the user's movements and controls the progress of the virtual character. During this experience, users increase their motivation by encountering various landscapes while tracking their performance and getting information about the calories they spend. This setup provides a fun, game-like atmosphere for a realistic walking experience.
Study: NCT06618287

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BMS-986507
Description: Specified dose on specified days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BMS-986507
Description: Specified dose on specified days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Specified dose on specified days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Specified dose on specified days
Study: NCT05590624

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lower-Carbohydrate Med-t-Diet
Description: Diet will focus on including:~* Lean protein sources~* High-quality fat~* High-quality carbohydrate sources that are rich in fiber~* Nuts and seeds~Diet will focus on limiting:~* Refined sugars~* High glycemic carbohydrates~* Seed oils that may cause inflammation~Diet Composition: 45% fats, 35% carbs, 20% protein

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lower-Carbohydrate Med-t-Diet
Description: Diet will focus on including:~* Lean protein sources~* High-quality fat~* High-quality carbohydrate sources that are rich in fiber~* Nuts and seeds~Diet will focus on limiting:~* Refined sugars~* High glycemic carbohydrates~* Seed oils that may cause inflammation~Diet Composition: 45% fats, 35% carbs, 20% protein

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low-Fat Med-t-Diet
Description: Diet will focus on including:~* Lean protein sources~* High-quality fat~* High-quality carbohydrate sources that are rich in fiber~* Nuts and seeds~Diet will focus on limiting:~* Refined sugars~* High glycemic carbohydrates~* Seed oils that may cause inflammation~Diet Composition: 70% carbs, 20% protein, 10% fat

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low-Fat Med-t-Diet
Description: Diet will focus on including:~* Lean protein sources~* High-quality fat~* High-quality carbohydrate sources that are rich in fiber~* Nuts and seeds~Diet will focus on limiting:~* Refined sugars~* High glycemic carbohydrates~* Seed oils that may cause inflammation~Diet Composition: 70% carbs, 20% protein, 10% fat
Study: NCT06679842

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: ascitis paracentesis
Description: ascitis paracentesis
Study: NCT06675812

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Information intervention
Description: The participant will receive information on what treatment that is offered in their municipal, how the help-seeking process goes (where they can be anonymous etc), and tailored information regarding the barriers that the participant has stated preventing him or her for seeking help today.
Study: NCT05970731

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Beclomethasone
Description: 84 mcg of Beclomethasone administered topically on an intranasal microsponge, placed in the olfactory cleft using a nasal endoscope, on day 1 and repeated on day 14.
Study: NCT06569628

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Contact Methodology in Long-term Care Centres for old adults
Description: Professionals know and use Envita Stories Methodology but do not apply it directly with these people.
Study: NCT05211960

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-based meditation
Description: AmDTx is a mindfulness-based meditation app that includes lessons, interactive exercises, and additional in-app features to practice mindfulness.
Study: NCT05226338

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-0502
Description: Formulation 1 Formulation 2 Formulation 3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-0502
Description: Formulation 1 Formulation 2 Formulation 3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-0502
Description: Formulation 1 Formulation 2 Formulation 3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-0502
Description: Formulation 1 Formulation 2 Formulation 3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-0502
Description: Formulation 1 Formulation 2 Formulation 3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-0502
Description: Formulation 1 Formulation 2 Formulation 3
Study: NCT05970731

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo (0.9% sodium chloride) administered topically on an intranasal microsponge, placed in the olfactory cleft using a nasal endoscope, on day 1 and repeated on day 14.