TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05284071

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Device: Actiste 1.0 and the Companion app with TBL Backend
Description: Actiste automatically logs and shares real-life data on blood glucose values and actual injected insulin doses. With Actiste's built-in sensor, the exact injected dose is displayed and saved in the device memory together with a time stamp, which makes it easy for the user to know how much and when the insulin was injected, and spot missed doses. This simplifies the daily diabetes care for the user and thus may improve the quality of life for people with diabetes and may improve the patients' adherence to treatment plans. Actiste automatically logs and shares real-life data on blood glucose values and actual injected insulin doses. With Actiste's built-in sensor, the exact injected dose is displayed and saved in the device memory together with a time stamp, which makes it easy for the user to know how much and when the insulin was injected, and spot missed doses. This simplifies the daily diabetes care for the user and thus may improve the quality of life for people with diabetes.
Study: NCT05874804

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Carry Life UF
Description: A 5-hour treatment with the Carry Life UF used with a 1.36% glucose PD fill.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 2.27% glucose peritoneal dialysis dwell
Description: A 5-hour CAPD dwell with a 2.27% glucose PD fluid.
Study: NCT04393103

Intervention type: DRUG
Group type: OTHER
Intervention: Intravenous Atropine Sulfate
Description: Atropine will be administered to ALL PATIENTS in Group A and group B by doubling dose method which comprised of administering atropine start-ing from 2mg and to double the dose and administer till complete atropinization. Following this, an infusion of 10-20% of the atropinizing dose was given every hour.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intravenous Atropine Sulfate
Description: Atropine will be administered to ALL PATIENTS in Group A and group B by doubling dose method which comprised of administering atropine start-ing from 2mg and to double the dose and administer till complete atropinization. Following this, an infusion of 10-20% of the atropinizing dose was given every hour.
Study: NCT05686980

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ABBV-552
Description: Oral Capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ABBV-552
Description: Oral Capsule
Study: NCT06571175

Intervention type: DIAGNOSTIC_TEST
Intervention: High frame rate echocardiography
Description: Conventional transthoracic echocardiography will be performed, with added 3D-imaging and acquisitions with high frame rate. The data from these patients will be anonymized and transferred for post-hoc analysis in dedicated computer software (GE Vingmed, EchoPac 2.6) and in validated machine learning algorithms.

Intervention type: DIAGNOSTIC_TEST
Intervention: High frame rate echocardiography
Description: Conventional transthoracic echocardiography will be performed, with added 3D-imaging and acquisitions with high frame rate. The data from these patients will be anonymized and transferred for post-hoc analysis in dedicated computer software (GE Vingmed, EchoPac 2.6) and in validated machine learning algorithms.

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: Cardiac MRI will be performed. In all patients without contraindications, a gadolinium-based contrast agent will be given.
Study: NCT04920682

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Reversal of moderate neuromuscular blockade
Description: Neostigmine 60 mcg/kg when TOF (Train-of-Four) = 3 and saline when TOF (T4 / T1)\> 0.4

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Reversal of superficial neuromuscular blockade
Description: Neostigmine 30 mcg/kg when TOF (T4 / T1)\> 0.4
Study: NCT06571175

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: Cardiac MRI will be performed. In all patients without contraindications, a gadolinium-based contrast agent will be given.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood test
Description: Conventional brachial venous blood samples will be drawn. Hematocrit value {in %} will be used to calculate CMR-derived exttracellular volume (ECV)

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood test
Description: Conventional brachial venous blood samples will be drawn. Hematocrit value {in %} will be used to calculate CMR-derived exttracellular volume (ECV)

Intervention type: DIAGNOSTIC_TEST
Intervention: ECG and Holter-ECG
Description: ECG/Holter-ECG will be performed, and the findings will be related to the imaging findings.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 min walking test
Description: 6 MWT will be performed, and the findings will be related to findings from CMRI/echocardiography.
Study: NCT06570356

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Geriatric Depression Scale - 15
Description: a validated screening tool designed to identify depression in older adults. It consists of 15 simple yes/no questions that assess depressive symptoms.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Geriatric Depression Scale - 15
Description: a validated screening tool designed to identify depression in older adults. It consists of 15 simple yes/no questions that assess depressive symptoms.
Study: NCT06691269

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Photobiomodulation
Description: Photomodulation (PBM) is a promising non-tissue penetrating (i.e. minimally invasive) approach for achieving tooth and soft tissue anesthesia/analgesia in dental patients. A patent pending near-infrared laser technology that aims to provide dental analgesia will be used for PBM. This intra-oral PBM device comes with a tip comprising of a series of photonic emitters with specific wavelengths that can go through the tooth structure and bone, blocking the nerve conduction like local anesthetics. Research has shown that one burst of light application (for about 20 second) can provide up to 15-20 minutes of pain relief. Based on existing research PBM does not present a serious risk to health, safety, or welfare of a subject.
Study: NCT05185453

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Strengthening Connections for Change
Description: Strengthening Connections for Change is a 12-session curriculum designed to strengthen adolescent-adult support networks, build leadership skills, foster community engagement, and challenge attitudes and behaviors that foster violence involvement. During the program, youth ages 13-17 years invite their self-identified key adult supports to jointly participate in programming including youth-focused, adult-focused and jointly focused activities. Towards the end of programming participants design and carry out a community project to strengthen intergenerational connections and promote community engagement.
Study: NCT04920682

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Two-step reversal
Description: Neostigmine 30 mcg/kg when TOF = 3 and neostigmine 30 mcg/kg when TOF (T4 / T1)\> 0.4

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% saline solution (SF) when TOF = 3 and when TOF (T4 / T1)\> 0.4
Study: NCT04894292

Intervention type: OTHER
Intervention: Non intervention
Description: During the study there is no extra intervention planned for the participants.

Intervention type: OTHER
Intervention: Non intervention
Description: During the study there is no extra intervention planned for the participants.
Study: NCT06002243

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: SPLASH echocardiography screening
Description: Screening echocardiogram performed by a briefly trained health worker with images reviewed off site by an expert cardiologist or cardiac sonographer to determine screening outcome. Screening outcome may include: screen positive, screen negative or uninterpretable images.
Study: NCT05185453

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Job Readiness Training
Description: Job Readiness Training uses a group discussion format to learn specific skills to prepare for employment including developing goals, seeking jobs, preparing for interviews, and so forth.
Study: NCT06471673

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BC1 cell line
Description: BC1 cell line is a different experimental, HER-2 positive, allogeneic, whole cell BC cell lines designed to secrete GM-CSF in situ and augment dendritic cell activity. Similar to the SV-BR-1-GM cell line (NCT03328026, IND 10312), the BC cell line is derived from the BC parent cell line, SV-BR-1, which expresses multiple tumor associated antigens (TAAs)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Bria-OTS regimen and CPI (tislelizumab)
Description: Biological: BC1~* BC1 inoculation intradermally at 4 sites~Drug: Low dose cyclophosphamide~* Pretreatment with low dose cyclophosphamide 2-3 days prior to BC1 inoculation~Drug: Interferon~* Subjects will receive low dose peginterferon alpha-2a on the same day as cell inoculation.~Drug: Tislelizumab~* CPI treatment will also be given on the same day as cell inoculation.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Bria-OTS regimen and CPI (tislelizumab) expansion cohort
Description: Biological: BC1~* BC1 inoculation intradermally at 4 sites~Drug: Low dose cyclophosphamide~* Pretreatment with low dose cyclophosphamide 2-3 days prior to BC1 inoculation~Drug: Interferon~* Subjects will receive low dose peginterferon alpha-2a on the same day as cell inoculation.~Drug: Tislelizumab~* CPI treatment will also be given on the same day as cell inoculation.
Study: NCT06691269

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Topical Benzocaine
Description: Topical Benzocaine at injection site to reduce discomfort of local infiltration

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Topical Benzocaine
Description: Topical Benzocaine at injection site to reduce discomfort of local infiltration

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Local Anesthesia
Description: Local infiltration using local anesthetics with epinephrine
Study: NCT06688331

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ex vivo expanded CD4+CD25+CD127- regulatory T cells (Tregs)
Description: regulatory T cells with the phenotype CD3(+)CD4(+)CD25(high)CD127(-)doublet(-)lin(-)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ex vivo expanded CD4+CD25+CD127- regulatory T cells (Tregs)
Description: regulatory T cells with the phenotype CD3(+)CD4(+)CD25(high)CD127(-)doublet(-)lin(-)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Anti-CD20 (rituximab)
Description: rituximab

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Anti-CD20 (rituximab)
Description: rituximab

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: intrevenous 0,9% NaCl

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: intrevenous 0,9% NaCl

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treg sham
Description: intrevenous 0,9% NaCl

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Treg sham
Description: intrevenous 0,9% NaCl
Study: NCT06222606

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgery with autofluorescence
Description: In the experimental group, the surgeon will use the EleVision IR camera system (Medtronic, USA) to visualize parathyroid glands during surgery.
Study: NCT06687278

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Interpersonal Relationship Psychotherapy-Based Intervention Program
Description: The Interpersonal Relationship Psychotherapy-Based Intervention Program is based on IPR and developed with reference to relevant literature and a previously published study (Cort et all., 2014). Following the development of the program, expert opinions were obtained from seven experts. The Interpersonal Relationship Psychotherapy-Based Intervention Program is a 2.5-3 month program comprising two individual and eight group sessions. Sessions will be held weekly, with each session lasting approximately 90 minutes.
Study: NCT06692465

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GT20029 Tincture
Description: 5mg (0.5%) and 10mg (1%) one single dose per day (QD) treatment over 12 weeks period; 5mg (0.5%) and 10mg (1%) twice per week (BIW) treatment, on every Monday and Thursday over 12 weeks period
Study: NCT05721469

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Art therapy
Description: Determining the mothers of children with eating disorders with the data obtained from the questionnaires and scales and separating them into randomized experimental and control groups, 8-12 sessions of 90 minutes of music, painting, ceramics, etc. were given to the mothers participating in the experimental group. Art Therapy Studies
Study: NCT06492551

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Trak exercise prescription protocol
Description: Online treatment based on therapeutic exercise using the Trak software. The patient will undergo 6 weeks of an exercise prescription protocol based on strength, balance, proprioception, and aerobic exercises. Physical therapy techniques to improve secretion management and respiratory mechanics will also be included.
Study: NCT06692465

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: GT20029 matching placebo
Description: 5mg (0.5%) and 10mg (1%) matching placebo one single dose per day (QD) treatment over 12 weeks period; 5mg (0.5%) and 10mg (1%) matching placebo twice per week (BIW) treatment, on every Monday and Thursday over 12 weeks period
Study: NCT06693700

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Indoor Air Quality Monitor AirGradient ONE
Description: Participants will be asked to set up an Indoor Air Quality Monitor AirGradient ONE (Model: I-9PSL) which is an award winning commercially available indoor air quality monitor designed to enable anyone to monitor their air quality in their home for about 60 days (8 weeks). Indoor air pollution levels within participating households will be measured using these AQMs.
Study: NCT06492551

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional rehabilitation plan in the gym
Description: Treatment is based on therapeutic exercise following a conventional rehabilitation plan. The patient will undergo 6 weeks of an exercise prescription protocol based on strength, balance, proprioception, and aerobic exercises. Physical therapy techniques will also be included to improve secretion management and respiratory mechanics.
Study: NCT06604481

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: eCoaching for Caregivers of Older Adults
Description: The experimental group receives an online intervention based on Cognitive Behavioral Therapy, Dialectical Behavioral Therapy, lifestyle intervention, and effective communication skills. This program is designed to operate individually on an e-platform. It consists of 6 weekly sessions, each lasting for less than 90 minutes. The content of the sessions focuses on teaching caregivers CBT techniques, lifestyle modifications to improve caregiving experiences, and effective communication strategies. In between each session, participants are assigned home practices to reinforce the skills learned further. All content will be included.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: eCoaching (need specific) for Caregivers of Older Adults
Description: The experimental group receives an online intervention based on Cognitive Behavioral Therapy, Dialectical Behavioral Therapy, lifestyle intervention, and effective communication skills as in eCoaching I. However, eCoaching II will include content specified to carer's specific need.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control Intervention for Caregivers of Older Adults
Description: The control group attends 6 weekly online sessions that primarily provide educational information about lifestyle factors and communication. These sessions aim to enhance the control group's knowledge and understanding of the factors that impact caregiving. Each session in the control group also lasts for 90 minutes. The focus of these activities will be on building practical caregiving skills and promoting overall well-being, rather than targeting any particular psychological or mental health-related factors directly.
Study: NCT06595004

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HCP1004
Description: Test Drug

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: RLD2401
Description: Reference drug
Study: NCT06321055

Intervention type: DRUG
Intervention: Regorafenib (Stivarga, BAY73-4506)
Description: Retrospective analysis.
Study: NCT05768178

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vemurafenib
Description: Participants will receive vemurafenib at a dose of 960 mg orally on a twice daily schedule throughout a 28-day cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cobimetinib
Description: Participants will receive cobimetinib at a dose of 60 mg (3 tablets of 20 mg) to be taken orally, once daily for 21 consecutive days (days 1 to 21 in each 28-day cycle); followed by a 7-day break.
Study: NCT06590350

Intervention type: OTHER
Intervention: Clinical nutrition counseling
Description: In the first phase, all patients admitted to the Departmental Simple Operating Unit Admission Room of Policlinico Universitario A. Gemelli will be screened for NRS-2002 upon admission.~Only patients with NRS-2002 ≥ 3 will subsequently be tracked via the Foundation's computer system (TrackCare®).~The patients will be managed by caregivers who may spontaneously request nutritional counseling, as is currently the case.~Patient data (laboratory tests, medical history, reason for admission, any instrumental test reports) and clinical outcomes (average length of hospitalization, complications, antibiotic therapy use, intensive care admission, mortality, re-hospitalization within 30 days) will be obtained from the Foundation's computer system (TrackCare®) and recorded in a dedicated Excel® spreadsheet.~Costs related to hospitalization and management of any complications will also be assessed.

Intervention type: OTHER
Intervention: Clinical nutrition counseling
Description: In the first phase, all patients admitted to the Departmental Simple Operating Unit Admission Room of Policlinico Universitario A. Gemelli will be screened for NRS-2002 upon admission.~Only patients with NRS-2002 ≥ 3 will subsequently be tracked via the Foundation's computer system (TrackCare®).~The patients will be managed by caregivers who may spontaneously request nutritional counseling, as is currently the case.~Patient data (laboratory tests, medical history, reason for admission, any instrumental test reports) and clinical outcomes (average length of hospitalization, complications, antibiotic therapy use, intensive care admission, mortality, re-hospitalization within 30 days) will be obtained from the Foundation's computer system (TrackCare®) and recorded in a dedicated Excel® spreadsheet.~Costs related to hospitalization and management of any complications will also be assessed.
Study: NCT06604195

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Modified sciatic nerve mobility exercises
Description: Each participant was made to lie down in a supine position on the treatment couch. The participant's leg was moved to about 30-45 degrees hip flexion with knee extension. The ankle was then moved to maximum dorsiflexion with inversion and hip internal rotation within the participant's tolerance, and this position was maintained for 30 seconds. While the therapist performed dorsiflexion with inversion and hip internal rotation in the supported straight leg raise position, the participant was instructed to actively flex the cervical spine slowly until they perceived a tolerable stretch sensation in the hamstring muscle and lower leg. The synchronous alternating movements were performed rhythmically for 10-15 repetitions. This maneuver was repeated 3 times in a single session, 3 days per week, and continued for 3 consecutive weeks.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Dynamic hamstring muscle stretching
Description: The participant was instructed to stand straight with the unaffected foot supported on the floor and the toes pointing forward. The heel of the testing leg was placed on an 18 high step with the toes directed upwards with knee extension. Once cued, the participant was asked to flex forward at the hip while maintaining the spine in a neutral position and reaching the arms forward. The knee joint remained fully extended as the participant continued to flex the hip until a gentle stretch was felt in the posterior thigh. Once the position was achieved, the participants were asked to hold it for 20-30 seconds. The same procedure was repeated 3 times daily, 3 days a week for three consecutive weeks.
Study: NCT06678282

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JY231 Injection
Description: The starting dose of this study was set at 1\~10×10\^6 transduction units (TU) / kg and escalated at 2\~5×107\^TU/kg and 6\~10×10\^7 TU/kg.
Study: NCT06678217

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Stroop task
Description: The Stroop task will be used as a mild, acute stressor since it has effects on anxiety and autonomic response. In each Stroop task condition, four coloured visual stimuli will be presented on a computer screen for 3 s with 7 s inter-stimulus interval. The stimuli will be coloured words naming the colour of the ink in the nonconflict task condition (e.g. GREEN written in green ink) and a different colour in the conflict task condition (e.g. GREEN written in red ink). The participants were asked to name the colour of the stimuli. The test will be administered using the online version of PsyToolKit (Stoet, 2021).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cold pressor test
Description: The participant lowers their hand in icy water to induce temporary tonic pain

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cold pressor test
Description: The participant lowers their hand in icy water to induce temporary tonic pain