TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05891704

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Hand therapy Rehabilitation intervention program that incorporate cultural reference
Description: The intervention will provide a conventional hand therapy rehabilitation intervention program that incorporates cultural reference based on Focused Acceptance and commitment Therapy ( FACT).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Hand therapy Rehabilitation intervention program
Description: The intervention will provide a conventional hand therapy rehabilitation intervention program
Study: NCT06572683

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulation
Description: Transcranial magnetic stimulation (TMS) is a noninvasive procedure that uses magnetic fields to stimulate nerve cells in the brain to improve symptoms of depression. Using pulsed magnetic fields, transcranial magnetic stimulation therapy stimulates the part of the brain thought to be involved with mood regulation. These magnetic fields do not directly affect the whole brain; they only reach about 2-3 centimeters into the brain directly beneath the treatment coil.As these magnetic fields move into the brain, they produce very small electrical currents. These electrical currents activate cells within the brain, causing them to rewire, a process called neuroplasticity.
Study: NCT04592874

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AL002
Description: Administered via intravenous (IV) infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AL002
Description: Administered via intravenous (IV) infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AL002
Description: Administered via intravenous (IV) infusion

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered via intravenous (IV) infusion
Study: NCT04788888

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Navitor Transcatheter Aortic Valve and FlexNav Delivery System
Description: For traditional application, the Navitor valve is indicated for transcatheter delivery in patients with symptomatic severe native aortic stenosis who are intermediate or low surgical risk.~For the valve-in-valve application, the Navitor valve is indicated for use in patients with symptomatic heart disease due to failure (stenosed, insufficient, or combined) of a surgical bioprosthetic aortic valve.~Subjects will undergo transcatheter aortic valve replacement (TAVR) with the Navitor valve and FlexNav Delivery system
Study: NCT06569368

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metronidazole
Description: Given by PO
Study: NCT04196777

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Audit-and-feedback
Description: We will provide feedback both at baseline and at regular intervals to the 3 intervention sites. At first, we will schedule one-on-one conference calls with urology providers and the antimicrobial stewardship team at each of the 3 intervention sites. These conference calls will include a review of guidelines, a review of the facility's data on excessive post-procedural antimicrobial use for urologic patients, and an anonymous comparison to all other VHA sites. Next, we will prospectively monitor excessive post-procedural antimicrobial use at all 3 sites and the entire VHA for 1 year. Data on hospital-level excessive post-procedural antimicrobial use specific to urologic patients (primary outcome) will be sent electronically to urology providers and the antimicrobial stewardship team at the intervention site every other month via electronic mail.
Study: NCT04942717

Intervention type: BEHAVIORAL
Intervention: CONVO intervention
Description: The CONVO intervention consists of oncology nurse-led discussions exploring patients' health-related values as part of routine oncology care for all patients, from the beginning of oncologic care. Nurses will use the Nurse's Values Discussion Guide. At these sites, chemotherapy nurses will deliver the CONVO discussion, as patients at these sites do not have primary nurses assigned and because oncology doctors, BPs and PAs do not work one-on-one as a pair with a unique nurse.

Intervention type: BEHAVIORAL
Intervention: CONVO intervention
Description: The CONVO intervention consists of oncology nurse-led discussions exploring patients' health-related values as part of routine oncology care for all patients, from the beginning of oncologic care. Nurses will use the Nurse's Values Discussion Guide. At these sites, chemotherapy nurses will deliver the CONVO discussion, as patients at these sites do not have primary nurses assigned and because oncology doctors, BPs and PAs do not work one-on-one as a pair with a unique nurse.
Study: NCT05412901

Intervention type: OTHER
Group type: OTHER
Intervention: discrimination task
Description: Participants perform a discrimination task while their brain activity is recorded with EEG. Beta power will be estimated using spectral decomposition techniques, zooming in on subject specific bands in temporospatial windows of interest, and correlated with (1) WM content, (2) decision outcome, and (3) behavioral performance (i.e., accuracy and RT).

Intervention type: OTHER
Group type: OTHER
Intervention: discrimination task
Description: Participants perform a discrimination task while their brain activity is recorded with EEG. Beta power will be estimated using spectral decomposition techniques, zooming in on subject specific bands in temporospatial windows of interest, and correlated with (1) WM content, (2) decision outcome, and (3) behavioral performance (i.e., accuracy and RT).

Intervention type: OTHER
Group type: OTHER
Intervention: discrimination task
Description: Participants perform a discrimination task while their brain activity is recorded with EEG. Beta power will be estimated using spectral decomposition techniques, zooming in on subject specific bands in temporospatial windows of interest, and correlated with (1) WM content, (2) decision outcome, and (3) behavioral performance (i.e., accuracy and RT).

Intervention type: OTHER
Group type: OTHER
Intervention: discrimination task
Description: Participants perform a discrimination task while their brain activity is recorded with EEG. Beta power will be estimated using spectral decomposition techniques, zooming in on subject specific bands in temporospatial windows of interest, and correlated with (1) WM content, (2) decision outcome, and (3) behavioral performance (i.e., accuracy and RT).

Intervention type: OTHER
Group type: OTHER
Intervention: discrimination task
Description: Participants perform a discrimination task while their brain activity is recorded with EEG. Beta power will be estimated using spectral decomposition techniques, zooming in on subject specific bands in temporospatial windows of interest, and correlated with (1) WM content, (2) decision outcome, and (3) behavioral performance (i.e., accuracy and RT).
Study: NCT04729907

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nusinersen
Description: Administered as specified in the treatment arm

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nusinersen
Description: Administered as specified in the treatment arm
Study: NCT05442749

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Niraparib
Description: Eligible patients will receive niraparib once daily, per os, continuously until loss of clinical benefit, unacceptable toxicity, death, patient or physician decision to withdraw, or pregnancy, whichever occurs first.~300 mg/day, continuously for patients with TB \>1.5- 3 ULN and/or ASAT/ALAT ≤5ULN.~Or 200mg/day initial dosing for patients with TB \>1.5 ULN and up to 3ULN and/or ASAT/ALAT \> 2.5 ULN and up to 5 ULN with increase to 300mg/day if 1) liver safety lab tests improve to Grade 1 according to NCI criteria (based on total bilirubin and AST/ALT) with bilirubin \< 1.5ULN) and 2) no grade \>1 related AE are reported.
Study: NCT05315102

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham intervention
Description: The participants head and/or spine will be moved in ways that include passive and active movements, similar to what is done when assessing the spine by a chiropractor. The sham intervention will also include the participants moving into adjustment setup positions similar to how the chiropractor would typically set up a patient with no joint pre-loading or adjustive thrust

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Chiropractic Care
Description: A registered chiropractor will assess the entire spine, and both sacroiliac joints will be assessed for vertebral subluxation by a registered chiropractor. The clinical indicators that will be used to assess the function of the spine before spinal adjustment intervention include assessing for joint tenderness to palpation manually palpating for a restricted intersegmental range of motion, assessing for palpable asymmetric intervertebral muscle tension, and any abnormal or blocked joint play and end-feel of the joints.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Physical therapy intervention
Description: The standardized treatment protocol will be provided according to the guidelines, which will include various modalities and treatment approaches, including stretching exercises; massage; strengthening exercises of weak muscles, weight-bearing, balance (static and dynamic) and gait training; electrical stimulation; treadmill use; and endurance training for the improvement of gait, motor function, strength and functional mobility in Cerebral Palsy children, where Conventional Therapy will be provided according to the respective needs of the individual patient.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical therapy intervention
Description: The standardized treatment protocol will be provided according to the guidelines, which will include various modalities and treatment approaches, including stretching exercises; massage; strengthening exercises of weak muscles, weight-bearing, balance (static and dynamic) and gait training; electrical stimulation; treadmill use; and endurance training for the improvement of gait, motor function, strength and functional mobility in Cerebral Palsy children, where Conventional Therapy will be provided according to the respective needs of the individual patient.
Study: NCT06408558

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hypobaric
Description: The effects of ambient pressure changes on glucose metabolism will be studied

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hypobaric
Description: The effects of ambient pressure changes on glucose metabolism will be studied

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ground level
Description: The effects of ambient pressure changes on glucose metabolism will be studied

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ground level
Description: The effects of ambient pressure changes on glucose metabolism will be studied
Study: NCT06247813

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Inflammation Support Formula
Description: Turmeric Extract (400mg), Bioperine (Black pepper, 10mg), Ashwagandha (500mg), and Olive Leaf Extract (250mg).

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nerve Health Formula
Description: Hydroxocobalamin (Vitamin B12, 1000mcg), Pyridoxal-5-Phosphate (Vitamin B6, 50mg), LMethylfolate (400mcg) and Trimethyl Glycine (Betaine, 750mg).

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Redox Support Formula
Description: N-Acetyl-L-Cysteine (500mg), CoQ10 (250mg), Acetyl-L-Carnitine (200mg), Alpha Lipoic Acid (200mg), Benfotiamine (300mg), Selenium (250mcg), Riboflavin (50mg), Zinc (15mg) and Copper (1.8mg).
Study: NCT06068309

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: CareAide App Usage
Description: The study participant uses the CareAide app in addition to prescribed usual therapeutic care
Study: NCT06582446

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Androgen Deprivation Therapy (ADT) - Goserelin
Description: The patients under ADT and the patients who will receive the ADT during the study will be included in the trial.~* ADT will be applied for 24 months in total~* ADT must be given concurrently and adjuvant

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: High-Dose-Rate Interstitial Brachytherapy (HDR BRT)
Description: HDR BRT Procedure will be performed using transperineal catheter implantation under transrectal US-guidance performed under anesthesia, spinal or general with patient in high lithotomy position.)

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: radiotherapy
Description: EBRT prostate + elective pelvis (Ultra-hypofractionated): 25 Gy in 5 Gy per fraction
Study: NCT04806386

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Psyllium
Description: Psyllium fiber powder baked into a bar is commonly used as a first line of treatment for patients with fecal incontinence.
Study: NCT05307211

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Cervical Interlaminar Epidural Steroid Injection
Description: Fluoroscopy-guided cervical interlaminar epidural steroid injection will be administered to patients with chronic neck pain due to cervical disc herniation. The injection area is cleaned 3 times with an antiseptic solution and covered with a sterile cloth. Local anesthesia with 2 ccs 3% prilocaine will be applied to the skin and subcutaneous tissues in the area of interest. Under fluoroscopy guidance, the needle is advanced into the C7-T1 intervertebral disc level. With the help of the loss of resistance technique, it is understood that the needle is in the epidural space, and second control is provided by administering contrast material. After the confirmation of needle place is done, a mixture of 12 mg dexamethasone, 1 cc 2% lidocaine, 1 cc saline is injected. The patient is taken to the restroom after the procedure and followed up for any complications.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cervical Interlaminar Epidural Steroid Injection
Description: Fluoroscopy-guided cervical interlaminar epidural steroid injection will be administered to patients with chronic neck pain due to cervical disc herniation. The injection area is cleaned 3 times with an antiseptic solution and covered with a sterile cloth. Local anesthesia with 2 ccs 3% prilocaine will be applied to the skin and subcutaneous tissues in the area of interest. Under fluoroscopy guidance, the needle is advanced into the C7-T1 intervertebral disc level. With the help of the loss of resistance technique, it is understood that the needle is in the epidural space, and second control is provided by administering contrast material. After the confirmation of needle place is done, a mixture of 12 mg dexamethasone, 1 cc 2% lidocaine, 1 cc saline is injected. The patient is taken to the restroom after the procedure and followed up for any complications.
Study: NCT05404139

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Enzalutamide
Description: Second-generation androgen pathway inhibitor (ARAT), oral tablet

Intervention type: OTHER
Group type: OTHER
Intervention: Standard of Care SBRT and ADT
Description: Standard of care stereotactic body radiation therapy (SBRT) and androgen deprivation therapy (ADT)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard of Care SBRT and ADT
Description: Standard of care stereotactic body radiation therapy (SBRT) and androgen deprivation therapy (ADT)
Study: NCT05874674

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nafamostat Mesylate
Description: Comparison effect of nafamostat and cnoxan
Study: NCT05799287

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Telitacicept
Description: Subcutaneous injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo to Telitacicept
Study: NCT06150612

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Unwinding Anxiety
Description: In the Unwinding Anxiety arm, participants will receive 6 weeks of an educational app and weekly facilitated mindfulness groups.
Study: NCT05131204

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cemdisiran
Description: Administered per protocol

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Eculizumab
Description: Administered per protocol

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Eculizumab
Description: Administered per protocol

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pozelimab
Description: Administered per protocol

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ravulizumab
Description: Administered per protocol

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ravulizumab
Description: Administered per protocol
Study: NCT04863729

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Asdzaan Be'eena Program
Description: The program consists of 11 weekly sessions conducted with girls ages 10-14 and their female caregivers. 5 of the 11 sessions will be taught to groups of 9-13 girls and their female caregivers, and 6 of the sessions will be taught to individual girl/female caregiver dyads. The choice to use a mix of group- and individual sessions is based on findings from the formative phase indicating certain topics should be taught in groups (e.g. Navajo history and reproductive health 101), and certain topics be taught in individual dyads (e.g. family values and the clan system).~Each of the sessions (group and individual) will be 60-90 minutes in duration and delivered by a trained Family Health Coach (FHC). Group sessions will take place at a local community center in a private room. Individual dyad sessions will take place in the girls'/female caregivers' home or another private place of their choosing, such as our local Johns Hopkins offices.
Study: NCT05993806

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L04RD1
Description: 1 tablet of L04RD1

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L04RD1
Description: 1 tablet of L04RD1

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L04TD3
Description: 1 tablet of L04TD3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L04TD3
Description: 1 tablet of L04TD3
Study: NCT05307211

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cervical Interlaminar Epidural Steroid Injection
Description: Fluoroscopy-guided cervical interlaminar epidural steroid injection will be administered to patients with chronic neck pain due to cervical disc herniation. The injection area is cleaned 3 times with an antiseptic solution and covered with a sterile cloth. Local anesthesia with 2 ccs 3% prilocaine will be applied to the skin and subcutaneous tissues in the area of interest. Under fluoroscopy guidance, the needle is advanced into the C7-T1 intervertebral disc level. With the help of the loss of resistance technique, it is understood that the needle is in the epidural space, and second control is provided by administering contrast material. After the confirmation of needle place is done, a mixture of 12 mg dexamethasone, 1 cc 2% lidocaine, 1 cc saline is injected. The patient is taken to the restroom after the procedure and followed up for any complications.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Neck Stabilization Exercises
Description: The physiotherapist will design an exercise protocol for neck stabilization. Each exercise will be applied three days a week throughout a 4-week program, accompanied by a physiotherapist, and will begin with 7 to 10 repetitions at first, increasing to 10 to 15 repetitions in the following weeks, taking into account the patient's condition. After the physiotherapist-assisted exercises are completed, the protocol will continue as home-based exercises until the assessments are completed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Neck and Scapular Stabilization Exercises
Description: The physiotherapist will design an exercise protocol for neck and scapular stabilization. Each exercise will be applied three days a week throughout a 4-week program, accompanied by a physiotherapist, and will begin with 7 to 10 repetitions at first, increasing to 10 to 15 repetitions in the following weeks, taking into account the patient's condition. After the physiotherapist-assisted exercises are completed, the protocol will continue as home-based exercises until the assessments are completed.
Study: NCT05379504

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard Health Education
Description: Participants randomized to the standard health education arm will receive the intervention at month 1 and then months 3, 6, 9, and 12 (coinciding with the quarterly interviews). The participant will use the tablet and telehealth platform to complete the interview and education session with research staff. The content of these sessions will be focused on helping the participant (and family member/caregiver as appropriate) understand their health data, assisting them with any technology issues and providing the participant with education on their condition(s) and any requested resources. Research staff will will also provide any additional health education if there are changes to conditions or new diagnoses after an outside provider visit.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self Management
Description: The self-management intervention will be delivered over the course of a year. There will be a minimum of four intervention sessions with each healthcare profession (OT, RN and SW) for 12 visits per participant. The team (OT, RN and SW) will meet twice during the first 2 months to determine a lead interventionist based on the participant's SMART goals and areas of concern. The lead interventionist will have three additional sessions with the participant and will be the point-person for sensor system alerts and messages. Goal Attainment Scaling \[83\] will be administered during the quarterly interview to assess participant progress on SMART goals. This measure is administered collectively with the participant, provides further accountability, offers opportunities to the participant for reflection on progress, and is a concrete measure of success of the self-management intervention.
Study: NCT06091475

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Other
Description: Withdrawal of mineralocorticoid receptor antagonists and/or sodium glucose cotransporter 2 inhibitors
Study: NCT05699408

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INS068 injection
Description: INS068 injected subcutaneously once daily. Treat-to-target dose titration during the trial

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Insulin Glargine
Description: Insulin Glargine injected subcutaneously once daily. Treat-to-target dose titration during the trial
Study: NCT06247917

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine, Busulfan and Melphalan
Description: Use Fludarabine, Busulfan and Melphalan as myeloablative conditioning regimen for untreated MDS-EB patients.
Study: NCT05238675

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 1291583
Description: BI 1291583

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 1291583
Description: BI 1291583

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 1291583
Description: BI 1291583

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo