TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06533397

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: postoperative CBCT
Description: A CBCT scan is performed following the 3- or 6-month-long healing period after SFE to evaluate the anatomy and healing of the augmented bone and the maxillary sinus.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: bone core biopsy
Description: At the time of dental implant placement, the first step of the implant bed preparation is performed using a trephine drill to harvest a bone core biopsy sample from the augmented bone. The biopsy sample is harvested from the implant bed, this way the patient is spared of excess surgical burden as this bone would be removed even if no biopsy sample was harvested during dental implant placement. The bone core biopsy samples are subjected to histomorphometric and microCT analysis.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: bone core biopsy
Description: At the time of dental implant placement, the first step of the implant bed preparation is performed using a trephine drill to harvest a bone core biopsy sample from the augmented bone. The biopsy sample is harvested from the implant bed, this way the patient is spared of excess surgical burden as this bone would be removed even if no biopsy sample was harvested during dental implant placement. The bone core biopsy samples are subjected to histomorphometric and microCT analysis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: dental implant placement
Description: Following the 3- or 6-month-long healing period following SFE, dental implants are placed non-submerged in the augmented bone under local anesthesia.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: dental implant placement
Description: Following the 3- or 6-month-long healing period following SFE, dental implants are placed non-submerged in the augmented bone under local anesthesia.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: fixed dental prosthesis (FDP) fabrication
Description: 3 months after dental implant placement, fixed dental prostheses are delivered on the dental implants.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: fixed dental prosthesis (FDP) fabrication
Description: 3 months after dental implant placement, fixed dental prostheses are delivered on the dental implants.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: bone grafting
Description: A synthetic bone graft material (Bond Apatite, Augma Biomaterials, Cesarea, Israel) is used during SFE.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: bone grafting
Description: A synthetic bone graft material (Bond Apatite, Augma Biomaterials, Cesarea, Israel) is used during SFE.
Study: NCT06094920

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Questionnaire: participants' perspectives toward the feasibility of participation in a trial at home with digital technologies
Description: Participant perspectives regarding the feasibility of participating in a home-based trial will be evaluated using a digital questionnaire. This questionnaire includes inquiries adapted from the validated Telehealth Usability Questionnaire, supplemented with additional questions employed in prior studies that assessed the feasibility of decentralized clinical trials. The web application Research Electronic Data Capture 10.0.23 (REDCap - www.projectredcap.org) will facilitate the administration of these digital questionnaires. Participants will receive a link to access the digital questionnaires via email. Weekly telephone calls will be conducted to evaluate adherence to study procedures and monitor the occurrence of adverse events.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Questionnaire: participants' perspectives toward the feasibility of participation in a trial at home with digital technologies
Description: Participant perspectives regarding the feasibility of participating in a home-based trial will be evaluated using a digital questionnaire. This questionnaire includes inquiries adapted from the validated Telehealth Usability Questionnaire, supplemented with additional questions employed in prior studies that assessed the feasibility of decentralized clinical trials. The web application Research Electronic Data Capture 10.0.23 (REDCap - www.projectredcap.org) will facilitate the administration of these digital questionnaires. Participants will receive a link to access the digital questionnaires via email. Weekly telephone calls will be conducted to evaluate adherence to study procedures and monitor the occurrence of adverse events.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Questionnaire: participants' perspectives toward the feasibility of participation in a trial at home with digital technologies
Description: Participant perspectives regarding the feasibility of participating in a home-based trial will be evaluated using a digital questionnaire. This questionnaire includes inquiries adapted from the validated Telehealth Usability Questionnaire, supplemented with additional questions employed in prior studies that assessed the feasibility of decentralized clinical trials. The web application Research Electronic Data Capture 10.0.23 (REDCap - www.projectredcap.org) will facilitate the administration of these digital questionnaires. Participants will receive a link to access the digital questionnaires via email. Weekly telephone calls will be conducted to evaluate adherence to study procedures and monitor the occurrence of adverse events.
Study: NCT05397015

Intervention type: OTHER
Intervention: No intervention will be done
Description: No intervention will be done
Study: NCT06172439

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: acupressure
Description: Women in the intervention group will receive acupressure for 12 minutes.The acupressure pressure points related to the gynecologic surgery to be performed are named as the large intestine (LI4), stomach (ST36) and spleen (SP6) meridians, respectively. These points are determined by expert opinion and are used for pain control.
Study: NCT05489796

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fentanyl selector
Description: Selector (1 ml; Lock out 10 min): Fentanyl 200 mcg + N/S 16 ml = total 20 ml

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fentanyl selector
Description: Selector (1 ml; Lock out 10 min): Fentanyl 200 mcg + N/S 16 ml = total 20 ml

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fentanyl continuous
Description: Continuous (2 ml/hr): fentanyl 700 mcg + N/S 86 ml = total 100 ml

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketorolac continuous
Description: Continuous (2 ml/hr): Ketorolac 180 mg + N/S 94 ml = total 100 ml
Study: NCT05237193

Intervention type: DIAGNOSTIC_TEST
Intervention: The level of CIN
Description: The extracted DNA from bile will be analyzed by UCAD to determine the level of CIN. And the patient will be followed for up to 2 years.

Intervention type: DIAGNOSTIC_TEST
Intervention: The level of CIN
Description: The extracted DNA from bile will be analyzed by UCAD to determine the level of CIN. And the patient will be followed for up to 2 years.
Study: NCT04817462

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Liver biopsy
Description: The study population is patients with either haemophilia A or B who have previously been administered gene therapy treatment in one of three specific gene therapy clinical trials. In this study they will have a liver biopsy performed to take up to 3 samples for laboratory analysis.
Study: NCT05142618

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supervised Physical Therapy
Description: The twice-per-week 8-week course of supervised physical therapy begins 2 weeks after surgery. It targets abdominal core function through progressive muscle retraining and strengthening, and patient-specific posture and body mechanics education.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Post-operative Precautions
Description: This intervention includes standard of care post-operative instructions typically given to patients undergoing ventral hernia repair across the world. These include limiting strenuous physical activity and a lifting restriction of no more than 10 pounds for 6 weeks. Binder use is also encouraged for 4-6 weeks after the operation.
Study: NCT05748834

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tucatinib
Description: Participants will receive tucatinib 300mg by mouth twice daily continuously (days 1-28) of each 28 day cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doxil
Description: Participants will receive Doxil 40mg/m2 intravenously on day 1 of each 28 day cycle (with a maximum cumulative dose of 550mg/m2).
Study: NCT05770011

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: intraoral scanner of nonsplinted scan bodies
Description: scanning of non splinted scan bodies
Study: NCT05930769

Intervention type: PROCEDURE
Intervention: Gynecological laparoscopic surgery without augmented reality
Description: Minimally invasive gynecological surgery assisted by laparoscope.

Intervention type: PROCEDURE
Intervention: Gynecological laparoscopic surgery with augmented reality
Description: Minimally invasive gynecological surgery assisted by laparoscope with the display of additional information through augmented reality.
Study: NCT05043558

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: beprostaglandin sodium
Description: beprostaglandin sodium
Study: NCT05511519

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ATI-450
Description: Oral, small molecule MK2 inhibitor

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Oral Tablet
Description: Placebo tablet manufactured to match ATI-450 in appearance
Study: NCT05597670

Intervention type: OTHER
Group type: OTHER
Intervention: traditional knee rehabilitation program
Description: Patients in this group will receive a traditional therapeutic knee rehabilitation program in the form of mini-squatting exercise (up to 45 degree knee flexion measured by a universal goniometer) , strengthening of hip abductors and external rotators

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: traditional knee rehabilitation program
Description: Patients in this group will receive a traditional therapeutic knee rehabilitation program in the form of mini-squatting exercise (up to 45 degree knee flexion measured by a universal goniometer) , strengthening of hip abductors and external rotators

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: proximal stabilization
Description: the principles of proximal stability will be explained to patients before initiation of treatment and patients will be asked to comply with these principles during exercise. These principles include learning how to activate transversus abdominus by abdominal bracing without allowing pelvis tilting and ensure neutral spine and diaphragmatic breathing during exercise.
Study: NCT05770011

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: impression material
Description: conventional recording

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: intraoral scanner of splinted scan bodies
Description: scanning of splinted scan bodies
Study: NCT04880954

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Soft Tissue Mobilization
Description: Soft Tissue Mobilization will be provided to participants by Licensed Chiropractor focusing on structures of the lower and upper leg. This will be provided for 20 minutes, once per week for 12 weeks.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Soft Tissue Mobilization
Description: Soft Tissue Mobilization will be provided to participants by Licensed Chiropractor focusing on structures of the lower and upper leg. This will be provided for 20 minutes, once per week for 12 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rehabilitation
Description: Participants will engage in 20 minutes of prescribed at-home exercise 5 times per week, for 12 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rehabilitation
Description: Participants will engage in 20 minutes of prescribed at-home exercise 5 times per week, for 12 weeks.
Study: NCT06168903

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ultrasound guided EOI block
Description: Before receiving general anesthesia, patients will be randomly assigned to one of the two study groups: the EOI block group or the ESPB group.~Using Ultrasound (Siemens ACUSON X300 Ultrasound System), guided blocks will be administered immediately after the induction of anesthesia and prior to surgical incision by consultant anesthesiologists who have experience in regional anesthesia and are familiar with the EOI and ESPB blocks

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound guided EOI block
Description: Before receiving general anesthesia, patients will be randomly assigned to one of the two study groups: the EOI block group or the ESPB group.~Using Ultrasound (Siemens ACUSON X300 Ultrasound System), guided blocks will be administered immediately after the induction of anesthesia and prior to surgical incision by consultant anesthesiologists who have experience in regional anesthesia and are familiar with the EOI and ESPB blocks
Study: NCT06449027

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: T Leuprolide Injectable Emulsion
Description: Arm 1 subjects were injected Leuprolide Injectable Emulsion 42mg every 24 weeks for 48 weeks, and taked Tamoxifen Citrate Tablets 10mg bid for 48 weeks.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Leuprorelin Acetate Microspheres for Injection
Description: Arm 2 subjects were injected Leuprorelin Acetate Microspheres for Injection 11.25mg every 12 weeks for 48 weeks, and taked Tamoxifen Citrate Tablets 10mg bid for 48 weeks.
Study: NCT04890665

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Online psychological intervention for healthcare workers
Description: The intervention is based on Cognitive Behavioral Therapy, Mindfulness, Behavioral Activation Therapy, Acceptance and Commitment Therapy and Positive Psychology, aimed at the Psychoeducation regarding the manifestations of anxiety, depression, burnout, fatigue compassion, posttraumatic stress disorder, and affectations in sleep quality and perception of life quality in healthcare workers.~And 3 complementary modules that according to the scientific literature could affect the mental health of healthcare workers related to how to deliver bad health news, Psychological first aid and how beliefs could influence physical and emotional self-care in the face of the COVID-19 pandemic.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online psychological intervention for healthcare workers
Description: The intervention is based on Cognitive Behavioral Therapy, Mindfulness, Behavioral Activation Therapy, Acceptance and Commitment Therapy and Positive Psychology, aimed at the Psychoeducation regarding the manifestations of anxiety, depression, burnout, fatigue compassion, posttraumatic stress disorder, and affectations in sleep quality and perception of life quality in healthcare workers.~And 3 complementary modules that according to the scientific literature could affect the mental health of healthcare workers related to how to deliver bad health news, Psychological first aid and how beliefs could influence physical and emotional self-care in the face of the COVID-19 pandemic.
Study: NCT05796791

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketamine Hydrochloride
Description: IM ketamine given in weekly session for a total of 3 weeks

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational enhancement therapy
Description: Brief motivational based therapy
Study: NCT05841784

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: MBCT-T
Description: MBCT-T is an 8-week group-based program that combines training in mindfulness and cognitive-behavioral therapy to reduce psychological distress and negative emotions. Each weekly 1-hour session will consist of a check-in, discussion, teaching, mindfulness or cognitive behavioral practice or exercise, inquiry by the facilitator, and summary of the at-home practice.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MBCT-T
Description: MBCT-T is an 8-week group-based program that combines training in mindfulness and cognitive-behavioral therapy to reduce psychological distress and negative emotions. Each weekly 1-hour session will consist of a check-in, discussion, teaching, mindfulness or cognitive behavioral practice or exercise, inquiry by the facilitator, and summary of the at-home practice.
Study: NCT06045507

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MK-8527
Description: MK-8527 capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MK-8527
Description: MK-8527 capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MK-8527
Description: MK-8527 capsule

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo to MK-8527
Description: Placebo capsule matched to MK-8527
Study: NCT05583526

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ritlecitinib
Description: 50 mg capsule

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching capsule
Study: NCT04869436

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dupilumab 300 MG/2 ML Subcutaneous Solution [DUPIXENT]
Description: Dupilumab will be administered subcutaneously for 6 months (1 initial 600mg dose + 5 300mg doses every 4 weeks)
Study: NCT06278987

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PENG block and cryoablation
Description: will receive an ultrasound guided PENG block with 20 mL of 0.5% bupivacaine followed by cryoablation of the PENG nerves.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: fascia iliaca compartment block
Description: will receive an ultrasound guided fascia iliaca compartment catheter with initial bolus of 20 mL of 0.5% bupivacaine followed by infusion of 0.2% ropivacaine at 10 mL per hour
Study: NCT06086171

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methadone Hydrochloride
Description: Methadone hydrochloride (0.10 mg/kg) administered intravenously at the induction of anaesthesia

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Saline solution
Study: NCT05217628

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Basimglurant
Description: Period 1: Basimglurant 1.5 to 3.5 mg QD titrated on individual tolerability.~Period 2: Patients randomized to receive either double blind Basimglurant at the tolerated dose from Period 1 or Placebo.~OLE: Open label Basimglurant at the dose tolerated from Period 2, patients previously assigned placebo in period to be titrated to the Period 1.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participant randomized to receive matching placebo once daily.
Study: NCT05841784

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MBCT-T
Description: MBCT-T is an 8-week group-based program that combines training in mindfulness and cognitive-behavioral therapy to reduce psychological distress and negative emotions. Each weekly 1-hour session will consist of a check-in, discussion, teaching, mindfulness or cognitive behavioral practice or exercise, inquiry by the facilitator, and summary of the at-home practice.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MBCT-T
Description: MBCT-T is an 8-week group-based program that combines training in mindfulness and cognitive-behavioral therapy to reduce psychological distress and negative emotions. Each weekly 1-hour session will consist of a check-in, discussion, teaching, mindfulness or cognitive behavioral practice or exercise, inquiry by the facilitator, and summary of the at-home practice.
Study: NCT06265532

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: EGCG 300 mg
Description: Participants will be administered EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo for EGCG 300 mg
Description: Participants will be administered placebo for EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: EGCG 600 mg
Description: Participants will be administered placebo for EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo for EGCG 600 mg
Description: Participants will be administered placebo for EGCG as part of the phase I study: Dose ranging study of oral epigallocatechin-3-gallate (EGCG) given daily for 12 weeks to patients with Idiopathic Pulmonary Fibrosis (IPF) evaluating safety, PK interactions with standard of care drugs, and biomarkers of drug effect.
Study: NCT05841784

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Booster Mindfulness Sessions
Description: Following the standard 8-week MBCT-T program, participants in certain arms will receive monthly MBCT-T booster sessions for 4 months of follow up. Each booster session will be 1 hour long. The sessions will include a concise review and summary of the main MBCT-T sessions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Booster Mindfulness Sessions
Description: Following the standard 8-week MBCT-T program, participants in certain arms will receive monthly MBCT-T booster sessions for 4 months of follow up. Each booster session will be 1 hour long. The sessions will include a concise review and summary of the main MBCT-T sessions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Website Support
Description: Participants in certain arms will receive continuous intervention support via the use of an online study website. The website will provide quick access to intervention materials and support to encourage participants to complete the at-home practice and apply the content of the MBCT-T program to real life situations.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Website Support
Description: Participants in certain arms will receive continuous intervention support via the use of an online study website. The website will provide quick access to intervention materials and support to encourage participants to complete the at-home practice and apply the content of the MBCT-T program to real life situations.