Study: NCT06267872

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD4BS CH505M5 Pr-NP1
Description: A ferritin NP expressing 8 copies of an HIV-1 Env protein trimer. To be administered intramuscularly (IM).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD4BS CH505M5 Pr-NP1
Description: A ferritin NP expressing 8 copies of an HIV-1 Env protein trimer. To be administered intramuscularly (IM).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD4BS CH505M5 Pr-NP1
Description: A ferritin NP expressing 8 copies of an HIV-1 Env protein trimer. To be administered intramuscularly (IM).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD4BS CH505M5 Pr-NP1
Description: A ferritin NP expressing 8 copies of an HIV-1 Env protein trimer. To be administered intramuscularly (IM).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD4BS CH505M5 Pr-NP1
Description: A ferritin NP expressing 8 copies of an HIV-1 Env protein trimer. To be administered intramuscularly (IM).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD4BS CH505M5 Pr-NP1
Description: A ferritin NP expressing 8 copies of an HIV-1 Env protein trimer. To be administered intramuscularly (IM).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD4BS CH505M5 Pr-NP1
Description: A ferritin NP expressing 8 copies of an HIV-1 Env protein trimer. To be administered intramuscularly (IM).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CH505TF chTrimer
Description: A stabilized chimeric SOSIP Env trimer protein with the N-terminal sequence of CH505 TF gp120 Env transplanted into the BG505 SOSIP sequence. To be administered IM.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CH505TF chTrimer
Description: A stabilized chimeric SOSIP Env trimer protein with the N-terminal sequence of CH505 TF gp120 Env transplanted into the BG505 SOSIP sequence. To be administered IM.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CH505TF chTrimer
Description: A stabilized chimeric SOSIP Env trimer protein with the N-terminal sequence of CH505 TF gp120 Env transplanted into the BG505 SOSIP sequence. To be administered IM.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CH505TF chTrimer
Description: A stabilized chimeric SOSIP Env trimer protein with the N-terminal sequence of CH505 TF gp120 Env transplanted into the BG505 SOSIP sequence. To be administered IM.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CH505TF chTrimer
Description: A stabilized chimeric SOSIP Env trimer protein with the N-terminal sequence of CH505 TF gp120 Env transplanted into the BG505 SOSIP sequence. To be administered IM.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CH505TF chTrimer
Description: A stabilized chimeric SOSIP Env trimer protein with the N-terminal sequence of CH505 TF gp120 Env transplanted into the BG505 SOSIP sequence. To be administered IM.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 3M-052-AF (labeled as AP 60-702)
Description: An aqueous formulation (AF) of the small molecule imidazoquinoline immune response modifier (IRM) 3M-052; toll-like receptor (TLR)7/8 agonist.