TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06319807

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital Health Intervention
Description: Participants will receive: 1) behavior change goals, 2) self-monitoring with tailored feedback, and 3) skills training. We will use text messaging to administer the intervention pieces. At baseline, each participant will complete a series of surveys to gain background information. Throughout the study participants will report their goal adherence in response to a text messaging prompt and immediately receive tailored feedback. Text messages will be deployed daily with 2 check in messages per week; participants will receive tailored feedback based on their response.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Safety Control
Description: Participants will receive: 1) behavior change goals, 2) self-monitoring with tailored feedback, and 3) skills training. We will use text messaging to administer the intervention pieces. At baseline, each participant will complete a series of surveys to gain background information. Throughout the study participants will report their goal adherence in response to a text messaging prompt and immediately receive tailored feedback. Text messages will be deployed daily with 2 check in messages per week; participants will receive tailored feedback based on their response.
Study: NCT04835428

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Treatment Group: AGN1 LOEP SV Kit
Description: The AGN1 LOEP SV Kit is intended for fixation of pathological fractures of the vertebral body using vertebral augmentation. Following saline lavage to create space, the AGN1 implant material is injected and hardens in situ to augment the fractured vertebral body. The AGN1 implant material is then resorbed and replaced with new bone.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Control Group: PMMA bone cement
Description: High viscosity PMMA bone cement will be used for vertebral augmentation.
Study: NCT06077864

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: survodutide
Description: once weekly subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: survodutide
Description: once weekly subcutaneous injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: once weekly subcutaneous injection
Study: NCT06144281

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nudge for PHPC NP Referral
Description: The attending and covering providers for inpatients who have been identified according to the study's inclusion criteria as appropriate for home palliative care services upon hospital discharge will be asked to refer their patient for these services.
Study: NCT06482268

Intervention type: COMBINATION_PRODUCT
Group type: OTHER
Intervention: Human induced pluripotent stem cell-derived dopaminergic progenitors (CT1-DAP001)
Description: Investigational PET agents will be synthesized at UCSD and administered to subjects according to the local institutional guidelines. IND applications for these agents are linked with the IND application for the study product, CT1-DAP001. The IND applications for the PET radiopharmaceuticals contains the manufacturing method, specifications, quality testing, clinical usage, and safety and efficacy information for individual PET agents.~Investigational Cell Injector Suniviion needle: The investigational instrument will be used to administer dopaminergic progenitors into the putamen. After aspirating cells, the instrument will be attached to a Leksell stereotactic frame to administer the cells into the brain.
Study: NCT05495490

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Osseodensification Internal Sinus Lift
Description: The osteotomy for the Osseodensification internal sinus lift begins with the advancement of a twist drill at 800 rpm and saline irrigation to within 1-2 mm of the sinus floor. The osteotomy is then widened by employing a series of osteotomy drills rotating at 800 rpm. Infracture of the sinus has occurred when the final osteotomy drill is advanced with gentle pressure at 100 rpm counterclockwise without irrigation until a bouncing sensation (haptic feedback) occurs. After infracture, the graft material will be injected into the osteotomy site. Using the final osteotomy drill, the graft is guided apically. This procedure is repeated incrementally to raise the membrane. Once sufficient space has been created beneath the antral membrane, the implant will be inserted followed by suturing.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Osteotome Internal Sinus Lift
Description: The osteotomy for the Osteotome internal sinus lift will begin with standard drills and saline irrigation to prepare the implant socket with a working length that is 1-2 mm shorter than the residual bone height as determined by radiographic examination. After preparation, a series of osteotomes of varying diameters will be sequentially utilized to widen the osteotomy and elevate the Schneiderian membrane by vertical tapping to create a greenstick fracture. The Valsalva maneuver (nasal blowing test) will be performed to determine the integrity of the Schneiderian membrane. During the osteotomy, the graft material will be injected and slowly placed into the elevated space using osteotomes until the desired depth is reached. Implant placement and suturing will conclude the procedure.
Study: NCT05553860

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Speech positioning technique
Description: Speech positioning technique

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Speech positioning technique
Description: Speech positioning technique
Study: NCT05069168

Intervention type: DIAGNOSTIC_TEST
Intervention: Echocardiography before and after TAVR
Description: Evaluation of severity of aortic stenosis using :peak velocity ,peak and mean pressure gradient and aortic valve area by continuity equation.-Evaluation of left ventricular dimensions ,volumes and systolic function as assessed by ejection fraction (EF) by m-mode and biplane simpson's method at apical 4 and 2 chambers view Speckle tracking echocardiography(STE) Apical four-, three-, and two-chamber views were used to obtain longitudinal and circumferential strain before and follow-up after TAVR.~cardiac CT :Routine full protocol before TAVR for evaluation and Detection and calculation of left ventricular fibrosis using extracellular volume.~Coronary angiography:evaluate the presence of CAD and calculation of syntax score(SS)

Intervention type: DIAGNOSTIC_TEST
Intervention: Echocardiography before and after TAVR
Description: Evaluation of severity of aortic stenosis using :peak velocity ,peak and mean pressure gradient and aortic valve area by continuity equation.-Evaluation of left ventricular dimensions ,volumes and systolic function as assessed by ejection fraction (EF) by m-mode and biplane simpson's method at apical 4 and 2 chambers view Speckle tracking echocardiography(STE) Apical four-, three-, and two-chamber views were used to obtain longitudinal and circumferential strain before and follow-up after TAVR.~cardiac CT :Routine full protocol before TAVR for evaluation and Detection and calculation of left ventricular fibrosis using extracellular volume.~Coronary angiography:evaluate the presence of CAD and calculation of syntax score(SS)
Study: NCT05475665

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Irbesartan/Amlodipine
Description: Irbesartan/Amlodipine once daily for 8 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Irbesartan
Description: Irbesartan once daily for 8 weeks
Study: NCT05470842

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous glucose monitoring (Dexcom G6)
Description: All participants will be issued with the Dexcom G6 device. The trial team will buy the readers or smartphones and sensors and provide the participants with all the necessary equipment. Participants will be shown how to wear the Dexcom G6 device, which they will be asked to wear for up to 10 days (=the lifespan of one sensor).~There will be no change in the standard care of the participants' diabetes management, during the study period.
Study: NCT06655532

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Exercise Program
Description: Patients allocated to this arm will receive the usual care plus supervised aerobic and moderate to high-intensity strength training twice weekly.

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Usual Care
Description: Patients allocated to this arm will receive standard medical treatment plus explicit recommendations for 12-week home-based moderate-intensity aerobic and strength training. They will also receive a weekly phone call and an in-person monthly visit to monitor exercise training performance.
Study: NCT06606249

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self-Help Plus (SH+)
Description: Self-Help Plus is a novel, brief, low-intensity intervention, recently developed by the World Health Organization (WHO) and intended to help people with and without mental disorders cope with distress stemming from diverse types of adversity.The key components of the program are based on acceptance and commitment therapy (ACT), a distinct form of cognitive-behavioural therapy. SH+ draws on ACT techniques of coping with stress, compassion and acceptance toward oneself and others, and living following one's values.~An online version called Doing what matters in times of stress is available as an illustrated guide and pre-recorded audio.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Psychological First Aid (PFA)
Description: Psychological First Aid (PFA) is also developed by the WHO and is a general supportive intervention, aimed at listening and understanding the needs and concerns of people, providing support without pressuring them to talk.
Study: NCT06660823

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: L-thyroxine
Description: Patients who show signs of delayed recovery defined as either prolonged ventilation for 48 hours or delayed conscious level recovery for 48 hours despite exclusion of muscle relaxants and/or sedative drugs. Those patients will undergo CT brain, CT chest and neurological examination to exclude structural damage as per institutional protocols. Also, metabolic profile screening including full kidney function, full liver function, electrolyte to exclude correctable metabolic abnormalities. and thyroid profile (TSH, free T3, free T4) sick euthyroid patients who are having normal FreeT3, normal Free T4, low TSH and low level of free T3 or freeT4 will be included in the study according lab reference.Daily assessment of conscious level according to Glasgow Coma Scale (GCS) and spontaneous breathing trial by ICU consultant (the investigator) till ICU discharge.~Patients will receive levothyroxine via Ryle, dose of 25 to 50 ug/ day according to BMI.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: patients will receive placebo in form of inert starch tablet
Study: NCT05623189

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HTD1801
Description: HTD1801,1250 mg, BID

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo, BID
Study: NCT04745559

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pneumococcal conjugate vaccine (PCV13)
Description: Licensed heptavalent pneumococcal conjugate vaccine (PCV13, Pneumococcal 13-valent conjugate vaccine

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD19 targeted CAR T Cell Therapy
Description: This is a personalized therapeutic approach that entails removal of T cells from patient's peripheral blood, genetic modification, activation and expansion in vitro to retarget cells against CD19 protein on the surface of B cells, and infusion of the genetically engineered cells back into the patient. CD19 is a surface protein that is expressed on B cells starting from early pre-B cells to mature fully differentiated B cells. Therefore, CD19-targeted CAR T cell therapy can effectively treat refractory B cell lymphomas.
Study: NCT05906784

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: group acupuncture
Description: Acupuncture will be delivered in a group setting, in a common space with multiple reclining chairs. Acupuncture treatments will include a 10-15 minute diagnostic intake with the acupuncturist, followed by administration of acupuncture needles retained for 20-40 minutes. Acupuncture points will be selected based on a treatment manual developed for the study. All treatments will be administered using sterile, disposable, surgical stainless steel acupuncture needles.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: group acupuncture
Description: Acupuncture will be delivered in a group setting, in a common space with multiple reclining chairs. Acupuncture treatments will include a 10-15 minute diagnostic intake with the acupuncturist, followed by administration of acupuncture needles retained for 20-40 minutes. Acupuncture points will be selected based on a treatment manual developed for the study. All treatments will be administered using sterile, disposable, surgical stainless steel acupuncture needles.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Integrative Group Medical Visits
Description: IGMV sessions will be weekly for 90 minutes in a group meeting space. Sessions will start with a check-in where participants can share their emotions, thoughts, hopes, and fears related to their health and pain and provide updates since the last session. Group sessions will be led by a primary care provider and a health educator and will include psychosocial support, tools for pain self-management, and psychoeducation for pain management. Invited experts will provide information on educational topics, including neurobiology of pain, medication safety, and connections between mood and pain, as well as participatory activities such as therapeutic movement or mindfulness practice.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Integrative Group Medical Visits
Description: IGMV sessions will be weekly for 90 minutes in a group meeting space. Sessions will start with a check-in where participants can share their emotions, thoughts, hopes, and fears related to their health and pain and provide updates since the last session. Group sessions will be led by a primary care provider and a health educator and will include psychosocial support, tools for pain self-management, and psychoeducation for pain management. Invited experts will provide information on educational topics, including neurobiology of pain, medication safety, and connections between mood and pain, as well as participatory activities such as therapeutic movement or mindfulness practice.
Study: NCT05085873

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sodium Oxybate injection
Description: * Induction dosage : 60 mg/kg by direct intravenous injection.~* Continuous dosage : 45 mg/kg/h by continuous intravenous injection.~* Additional dosage if the Richmond Agitation Sedation Scale (RASS) score exceeds -4 : 1000 mg sodium oxybate by direct intravenous injection bolus every hour at most until RASS score reaches -4.~Sedation maintained until patient death.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Midazolam injection
Description: * Induction dosage : 1 mg every 3 min by direct intravenous injection until RASS score reaches -4 (with a maximum of 30 min).~* Continuous dosage : Half of titration dosage every hour by continuous intravenous injection.~* Additional dosage if the RASS score exceeds -4 : 1 mg every 3 min by direct intravenous injection (without exceeding 10 mg/h).~Sedation maintained until patient death.
Study: NCT06219512

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CPET exercise prescription
Description: Exercise mode: walk Frequency: 5 times/week

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: 6MWT exercise prescription
Description: Exercise mode: walk Frequency: 5 times/week

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Regular exercise
Description: Regular exercise
Study: NCT04814134

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CPNS Therapy
Description: Endovascular stimulation of the cardiac autonomic nerves in addition to standard of care
Study: NCT06662032

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LumbaCure®
Description: LumbaCure® is a robotic system that systematically moves the spine of affected patients with a complex proprietary algorithm.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Rehab program
Description: Standard rehabilitation program

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rehab program
Description: Standard rehabilitation program
Study: NCT06662370

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Replacement of the esophagus with a decellularized human esophagus graft
Description: The Decellularized Human Esophagus (DHE) will be surgically implanted under general anesthesia via right or left thoracotomy or cervicotomy, depending on the location of the stenosis, to replace the esophageal defect created by resection of the stenosis. An omentoplasty is performed laparoscopically beforehand to provide secondary coverage of the graft area. A temporary esophageal stent is placed endoscopically to cover the DHE and the two anastomoses for a period of 3 months, to prevent the development of an anastomotic fistula and stenosis of the graft area.
Study: NCT06658678

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Receiving an educational intervention
Description: Patient not receiving any educational intervention
Study: NCT06659198

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: total hip replacement
Description: minimally-invasive hip replacement

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: total hip replacement
Description: minimally-invasive hip replacement
Study: NCT06607380

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TNM002
Description: A single intramuscular (IM) gluteal injection

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Adsorbed tetanus vaccine
Description: A single IM deltoid injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TNM002 + adsorbed tetanus vaccine
Description: A single IM gluteal injection+ a single IM deltoid injection
Study: NCT04814134

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard of care
Description: Available standard treatment

Intervention type: OTHER
Group type: OTHER
Intervention: Standard of care
Description: Available standard treatment
Study: NCT05438056

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: education with mobile application
Description: providing training to mothers of premature babies with a mobile application
Study: NCT05077397

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: StO2
Description: InSpectra Tissue Spectrometer Model 1615 probe (Hutchinson Technology Inc. Hutchinson, MN, USA) probes will be placed on the skin area corresponding to the patients' liver lodge prior to induction of anesthesia. In addition, the probes of both devices will be placed in the renal site on the same side. Basal values will be measured with both devices and StO2 values in the devices will be recorded every 15 minutes. Probes will not be removed during surgery and for 24 hours postoperatively.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: O3
Description: O3TM Regional Oximeter System (O3 System, Masimo Corporation, Irvine, CA) probes will be placed on the skin area corresponding to the patients' liver lodge prior to induction of anesthesia. In addition, the probes of both devices will be placed in the renal site on the same side. Basal values will be measured with both devices will be recorded every 15 minutes. Probes will not be removed during surgery and for 24 hours postoperatively.
Study: NCT06334510

Intervention type: BIOLOGICAL
Intervention: One dose of quadrivalent influenza virus split vaccine was administered
Description: Safety observation: All 4900 vaccine recipients participated in the safety observation after vaccination, and were followed up for adverse events (AE) within 30 minutes and 0-30 days after vaccination, and SAEs within 6 months after vaccination.~In addition to 1050 recipients aged 18-59 years who were included in the first layer test, 350 recipients aged 3-17 years and 350 recipients aged ≥60 years were randomly selected from each group. Blood samples were collected before and 30 days after vaccination for influenza virus HI antibody detection.

Intervention type: BIOLOGICAL
Intervention: One dose of quadrivalent influenza virus split vaccine was administered
Description: Safety observation: All 4900 vaccine recipients participated in the safety observation after vaccination, and were followed up for adverse events (AE) within 30 minutes and 0-30 days after vaccination, and SAEs within 6 months after vaccination.~In addition to 1050 recipients aged 18-59 years who were included in the first layer test, 350 recipients aged 3-17 years and 350 recipients aged ≥60 years were randomly selected from each group. Blood samples were collected before and 30 days after vaccination for influenza virus HI antibody detection.
Study: NCT05773508

Intervention type: DEVICE
Intervention: Video regulation and emergency kit
Description: Video regulation and emergency kit
Study: NCT05230771

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Palliative surgery after translational therapy
Description: A total, distal, or proximal gastrectomy with D1 lymph node dissection was done depending on tumour after translational therapy .~location.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Chemotheraoy along
Description: Patients receive only the prescribed chemotherapy.