TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05704296

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Y-composite grafting
Description: Saphenous vein is used as a Y-composite graft during coronary artery bypass grafting

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Aortocoronary grafting
Description: Saphenous vein is used as an aortocoronary graft during coronary artery bypass grafting
Study: NCT05014282

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nicotine lozenge
Description: Participants will be provided with a 10-week supply of nicotine lozenges

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Smartphone-delivered automated treatment
Description: An interactive smartphone-based intervention that comprises content delivered via audio/video clips and text content automatically each week to the participant
Study: NCT04925544

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: VK-2019
Description: VK-2019 binds to EBNA1 and inhibits EBNA1 DNA binding activity. VK-2019 API is synthesized by Anthem BioSciences Pvt. Ltd and formulated into capsules by Emerson Resources Inc,
Study: NCT04404400

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Investigational products administration
Description: Investigational products include:~* Hydrocortisone hemisuccinate 50 mg: one intravenous injection every 6 hours, and~* 9 alpha fludrocortisone 50 μg: one tablet per day via a nasogastric tube.~All treatments will be stopped after 7 days or until the patient has left the intensive care unit (whichever occurs first) without tapering off.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo administration
Description: Placebos for hydrocortisone and for fludrocortisone, administered in same manner as the active drugs in the interventional arm, for 7 days.
Study: NCT06508996

Intervention type: DIAGNOSTIC_TEST
Intervention: Xpert HCV
Description: Detection of HCV RNA by Xpert HCV test
Study: NCT05539911

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Fentanyl
Description: 50 mic fentanyl added as an adjuvant

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fentanyl
Description: 50 mic fentanyl added as an adjuvant
Study: NCT05987150

Intervention type: RADIATION
Intervention: Variation in anisotropy of the Spinal Cord using diffusion tensor imaging
Description: All examinations were performed on a 3.0-T MRI machine with a 12-channel spine special coil (Ingenia CX, Philips Healthcare, Best, the Netherlands). The multi-sequence MRI protocol included conventional T1-weighted (sag \& tra), T2-weighted (sag \& tra), and DTI sequence.

Intervention type: RADIATION
Intervention: Variation in anisotropy of the Spinal Cord using diffusion tensor imaging
Description: All examinations were performed on a 3.0-T MRI machine with a 12-channel spine special coil (Ingenia CX, Philips Healthcare, Best, the Netherlands). The multi-sequence MRI protocol included conventional T1-weighted (sag \& tra), T2-weighted (sag \& tra), and DTI sequence.
Study: NCT05915351

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Enfortumab vedotin
Description: Enfortumab vedotin 1.25 mg/kg on D1, D8, D15 every 28 days
Study: NCT05987150

Intervention type: RADIATION
Intervention: Variation in anisotropy of the Spinal Cord using diffusion tensor imaging
Description: All examinations were performed on a 3.0-T MRI machine with a 12-channel spine special coil (Ingenia CX, Philips Healthcare, Best, the Netherlands). The multi-sequence MRI protocol included conventional T1-weighted (sag \& tra), T2-weighted (sag \& tra), and DTI sequence.
Study: NCT05158257

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: balloon and Stent
Description: balloon dilatation combined stent angioplasty
Study: NCT06570408

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Western Ontario and McMaster University Osteoarthritis Index (WOMAC)
Description: 1. WOMAC is widely used in the evaluation of Hip and Knee Osteoarthritis. It is a self-administered questionnaire consisting of 24 items divided into 3 subscales

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Western Ontario and McMaster University Osteoarthritis Index (WOMAC)
Description: 1. WOMAC is widely used in the evaluation of Hip and Knee Osteoarthritis. It is a self-administered questionnaire consisting of 24 items divided into 3 subscales

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Visual Analogue Scale (VAS)
Description: 2. VAS is one of the pain rating scales used in epidemiologic and clinical research to measure the intensity or frequency of various symptoms.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Visual Analogue Scale (VAS)
Description: 2. VAS is one of the pain rating scales used in epidemiologic and clinical research to measure the intensity or frequency of various symptoms.

Intervention type: DIAGNOSTIC_TEST
Group type: PLACEBO_COMPARATOR
Intervention: Kellgren Lawrence Grading Scale (KL score)
Description: 3. KL score is the most widely used clinical tool for the radiographic diagnosis of OA.Each radiograph was assigned a grade from 0 to 4,

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Kellgren Lawrence Grading Scale (KL score)
Description: 3. KL score is the most widely used clinical tool for the radiographic diagnosis of OA.Each radiograph was assigned a grade from 0 to 4,

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Quality of Life Questionnaires and Assessments:
Description: 4. Quality of Life Questionnaires and Assessments: include quality of life, intestinal tract, conscious assessment of pain relief.etc.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Quality of Life Questionnaires and Assessments:
Description: 4. Quality of Life Questionnaires and Assessments: include quality of life, intestinal tract, conscious assessment of pain relief.etc.
Study: NCT05574400

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Dextrose Water
Description: Dextrose 5% in water

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Caffeine citrate
Description: Low-dose caffeine citrate (1.5 mg/kg)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Caffeine citrate
Description: High-dose Caffeine citrate (3 mg/kg)
Study: NCT06074185

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ipratropium Bromide
Description: The study intervention involves implementing a treatment bundle that includes inhaled ipratropium bromide and dexamethasone.
Study: NCT05158257

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: endovascular debulking and DCB
Description: endovascular debulking combined drug-coated balloon
Study: NCT06052033

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: CO2
Description: CO2 laser treatment is a surgical procedure that employs a high-powered carbon dioxide laser beam to precisely ablate cervical lesions. The laser is applied with a depth of 7-10mm and a width of 3-5mm beyond the lesion area in a single session. This intervention aims to address persistent low-grade cervical lesions associated with high-risk HPV infection.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: CO2
Description: CO2 laser treatment is a surgical procedure that employs a high-powered carbon dioxide laser beam to precisely ablate cervical lesions. The laser is applied with a depth of 7-10mm and a width of 3-5mm beyond the lesion area in a single session. This intervention aims to address persistent low-grade cervical lesions associated with high-risk HPV infection.
Study: NCT05144256

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitapivat
Description: Tablets or granules
Study: NCT06126939

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Educational training based on the Denver model
Description: In addition to routine health guidance, one-to-one parent classes were conducted to guide parents to interact with children once a week for 1h each time; A group leader was assigned to supervise the formulation of the intervention plan and ensure the quality of the intervention. The intervention lasted for 3 months
Study: NCT05643833

Intervention type: OTHER
Intervention: no intervention
Description: no intervention

Intervention type: OTHER
Intervention: no intervention
Description: no intervention

Intervention type: OTHER
Intervention: no intervention
Description: no intervention

Intervention type: OTHER
Intervention: no intervention
Description: no intervention
Study: NCT04762251

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Time-restricted eating
Description: Time restricted eating for a self-selected 9 hour window per day

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Current Best Practice
Description: Best practice guidelines to improve diet quality
Study: NCT06267339

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: transcranial random noise stimulation
Description: This intervention will give children tRNS during reaching or grasping repetitive movements.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: transcranial random noise stimulation
Description: This intervention will give children tRNS during reaching or grasping repetitive movements.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sham stimulation
Description: This intervention will give children sham stimulation during reaching or grasping repetitive movements.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sham stimulation
Description: This intervention will give children sham stimulation during reaching or grasping repetitive movements.
Study: NCT05644106

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: personal sound amplification product, hearing aid
Description: the device for hearing gain in sensorineural hearing loss

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: personal sound amplification product, hearing aid
Description: the device for hearing gain in sensorineural hearing loss
Study: NCT04556045

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise therapy
Description: The exercise therapy intervention will last 4 weeks. Each participant assigned to this intervention will receive a personalized ET regimen, including in-person, supervised exercise sessions; other activities to be followed at home. Participants will exercise between one and seven times per week depending on their tolerance to the treatment and exercise program.
Study: NCT06626854

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: RF-PNS
Description: Noninvasive peripheral nerve stimulator using interferential multi source radio frequency
Study: NCT05144256

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitapivat
Description: Tablets or granules

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitapivat-matching placebo
Description: Tablets or granules

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Mitapivat-matching placebo
Description: Tablets or granules
Study: NCT04660929

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CT-0508
Description: anti-HER2 CAR macrophages

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CT-0508
Description: anti-HER2 CAR macrophages

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CT-0508
Description: anti-HER2 CAR macrophages

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CT-0508
Description: anti-HER2 CAR macrophages
Study: NCT05344118

Intervention type: OTHER
Intervention: Survey
Description: REDCap survey
Study: NCT06146959

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Corrective Kinesiology taping
Description: corrective kinesiology tape is a form of biomechanical tape that is used with specific tension to get a corrective effect

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Non corrective kinesiology tape
Description: Non-corrective kinesiology tape is a form of biomechanical tape that is used without any tension

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Home exercise program
Description: Intrinsic foot strengthening and stretching exercises
Study: NCT05736250

Intervention type: DIAGNOSTIC_TEST
Intervention: biopsie
Description: gingival biopsie
Study: NCT06249139

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Compass for Care (Well-being intervention)
Description: Participants receive 12 weekly modules containing interactive activities and static content and tailored messages delivered via text message or email. The intervention focuses on five self-care behaviors critical to ADRD caregiver well-being: 1) taking time to recharge; 2) finding information about your loved one's diagnosis and needs; 3) discovering your strengths and limits; 4) exploring outside help; and 5) seeking emotional support.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Compass for Care (Safety intervention)
Description: Participants receive 12 weekly modules and tailored messages delivered via text message or email. The intervention focuses on safety behaviors (e.g., weather safety, first aid, home safety, etc.)
Study: NCT06066749

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: NIOSH certified N95 personal face covering (mask)
Description: During the this final exposure session, participants will be randomly assigned to wear an N95 respirator (3M cat. #: 9205+). Participants will be instructed on how to wear the mask to ensure a proper fit before entering the chamber.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Surgical Mask
Description: During the this final exposure session, participants will be randomly assigned to wear an ear loop style surgical mask. Participants will be instructed on how to wear the mask to ensure a proper fit before entering the chamber.
Study: NCT04922554

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Omadacycline Oral Tablet
Description: omadacycline 300 mg orally, once daily (150 mg tablets x 2)

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo tablets resembling omadacycline orally, once daily (x 2 tablets)
Study: NCT00789464

Intervention type: DIETARY_SUPPLEMENT
Group type: OTHER
Intervention: Lactobacillus reuteri DSM 17938
Description: DSM 17938 drops (10\^8 cfu/dose of 5 drops) + placebo elixir once daily for 1 year.

Intervention type: DRUG
Group type: OTHER
Intervention: trimethoprim/sulfamethoxazole
Description: Trimethoprim/sulfamethoxazole elixir (TMP/SMZ) (2 mg/kg), a standardized oral antibiotic prophylaxis, plus placebo capsule once daily for 1 year.
Study: NCT03725345

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: MRI Scanner
Description: Participants will enter the MRI scanner and complete a series of computer tasks that include noise blasts while undergoing brain scans that measure the structure and function of the brain

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: MRI Scanner
Description: Participants will enter the MRI scanner and complete a series of computer tasks that include noise blasts while undergoing brain scans that measure the structure and function of the brain
Study: NCT04921631

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Early Integration of Specialty Palliative Care with Critical Care
Description: The PC team will visit the patient within 24 hours of randomization and the consultation will address the following domains of PC: illness understanding and goals of care conversations with patients/surrogates; symptom assessment and management; spiritual needs; patient and family coping and support; and care coordination and transitions. The initial family meeting will be scheduled to occur within two days of randomization. Follow-up visits will be conducted by the PC MD/APP every weekday. During this time, the ICU and PC team will be in daily communication. The PC team will continue to follow the patient in the hospital once discharged from ICU. Prior to discharge, the PC team will document patient goals and preferences for future treatment, coordinate appropriate PC services in the home and/or outpatient clinic settings and contact the patient's primary physician to provide an update on the patient's hospital stay.
Study: NCT03921801

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Gait retraining
Description: Gait retraining using real-time electromyography biofeedback performed once per week for eight weeks.~During the gait retraining session the participant is walking on a treadmill while receiving information on calf muscle activation. A single session includes five bouts of walking each lasting for 5 minutes. During the first bout, the participant is receiving feedback (visual and auditive) on soleus muscle activation with the aim to increase it by 20% from their normal walking. During the second bout, the participant is receiving feedback (visual and auditive) on medial gastrocnemius muscle activation with the aim to decrease it by 20% from their normal walking. During the last three bouts, the participant is receiving feedback (visual and auditive) on the soleus to medial gastrocnemius muscle activation ratio with the aim to increase it by 20% from their normal walking. If hitting the target, the aim is increased by 5% for the subsequent bout.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gait retraining + strength training
Description: Gait retraining using real-time electromyography biofeedback performed once per week and home-based calf muscle strength training performed three times per week for eight weeks.~The gait retraining is identical to the one intervention described for the intervention group Gait retraining.~The strength training is performed three times per week except for the first week in which it is performed two times. The session contained a warm-up (3x10 repetitions of two-legged heel raises) and maximal isometric calf muscle contractions. The maximal contractions are performed using a custom device with the ankle in dorsiflexion and the knee flexed by 100-120 degrees. Three sets of 10 repetitions (3-second contraction and 3-second rest) are performed with both legs and with maximal effort and 1-minute rest between the sets.
Study: NCT05232539

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Intraoperative Optical Coherence Tomography (iOCT)
Description: The use of iOCT during surgery offers the advantage of a new view of the operating field, theoretically allows more precise performance and can also change decision-making mechanisms during surgery with more precise visual control of some surgical steps.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Intraoperative Optical Coherence Tomography (iOCT)
Description: The use of iOCT during surgery offers the advantage of a new view of the operating field, theoretically allows more precise performance and can also change decision-making mechanisms during surgery with more precise visual control of some surgical steps.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Intraoperative Optical Coherence Tomography (iOCT)
Description: The use of iOCT during surgery offers the advantage of a new view of the operating field, theoretically allows more precise performance and can also change decision-making mechanisms during surgery with more precise visual control of some surgical steps.
Study: NCT05871463

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MSC-derived exosomes
Description: Patients will receive standard medication plus MSC-derived exosomes at a final dose of 40mg in three weeks. Standard medication includes: a) treatment of the underlying cause of cirrhosis such as drug treatment of hepatitis B and C. b) symptomatic treatment of port complications such as ascites, prevention of variceal bleeding, treatment and prevention of hepatic encephalopathy.
Study: NCT05405023

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Concentric exercises with wrist mobilization
Description: Participants will receive concentric exercise including wrist flexion, extension, and abduction, adduction, supination and pronation plus wrist mobilizations with movements.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Concentric exercises without wrist mobilization
Description: Participants will receive concentric exercises only.
Study: NCT05870215

Intervention type: OTHER
Intervention: Visit 1: Clinical exam and questionnaires
Description: Medical history and examination, including vital signs, inhaler technique and adherence check (using prescript refills via the Dossier Santé Québec and/or calls to the community pharmacy), 5-item Asthma Control Questionnaire (ACQ-5), dyspnea rated on the modified Medical Research Council scale (mMRC), visual analog scale (VAS) for six respiratory symptoms, Pittsburgh Vocal Cord Dysfunction Index, Nijmegen Questionnaire, Hospital Anxiety and Depression Scale.

Intervention type: OTHER
Intervention: Visit 1: Clinical exam and questionnaires
Description: Medical history and examination, including vital signs, inhaler technique and adherence check (using prescript refills via the Dossier Santé Québec and/or calls to the community pharmacy), 5-item Asthma Control Questionnaire (ACQ-5), dyspnea rated on the modified Medical Research Council scale (mMRC), visual analog scale (VAS) for six respiratory symptoms, Pittsburgh Vocal Cord Dysfunction Index, Nijmegen Questionnaire, Hospital Anxiety and Depression Scale.

Intervention type: OTHER
Intervention: Visit 1: Respiratory physiology
Description: FeNO measurement (NIOX VERO device), pre/post-bronchodilator oscillometry (Tremoflo), and spirometry (including forced expiratory volume in 1 second (FEV1) reversibility, FEV1/FVC, peak expiratory flow).

Intervention type: OTHER
Intervention: Visit 1: Respiratory physiology
Description: FeNO measurement (NIOX VERO device), pre/post-bronchodilator oscillometry (Tremoflo), and spirometry (including forced expiratory volume in 1 second (FEV1) reversibility, FEV1/FVC, peak expiratory flow).
Study: NCT04760236

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Oral Cholera Vaccine Simplified (OCV-S)
Description: * Manufacturer: EuBiologics Co., Ltd.~* Oral administration

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Oral Cholera Vaccine Simplified (OCV-S)
Description: * Manufacturer: EuBiologics Co., Ltd.~* Oral administration

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Oral Cholera Vaccine Simplified (OCV-S)
Description: * Manufacturer: EuBiologics Co., Ltd.~* Oral administration

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Shanchol™
Description: * Manufacturer: Shantha Biotechnics~* Oral administration
Study: NCT05583669

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DS-2325a
Description: Subcutaneous injection (starting dose 300 mg)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Subcutaneous injection