TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06529718

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ivonescimab
Description: 20 mg/kg IV infusion every 3 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: FOLFOX regimen
Description: oxaliplatin 85 mg/m² IV, leucovorin 200 mg/m² IV (or folinic acid 400 mg/m²), and fluorouracil (5-FU) 400 mg/m² IV bolus; followed by 5 FU 2400 mg/m² as a 46 hour continuous IV infusion, every 2 weeks
Study: NCT05527210

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Prebiotic
Description: Prebiotin® is a fine, white to slightly yellow powder, which is mixed into water and has a slightly sweet taste.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Prebiotic
Description: Placebo prebiotic mixed into water
Study: NCT06529029

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Sigma-Stim
Description: Right Ultra-Brief Low Amplitude Seizure Therapy at 600mA or 700mA vs Right Unilateral Ultra-Brief Standard ECT at 800mA.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sigma-Stim
Description: Right Ultra-Brief Low Amplitude Seizure Therapy at 600mA or 700mA vs Right Unilateral Ultra-Brief Standard ECT at 800mA.
Study: NCT06528717

Intervention type: PROCEDURE
Intervention: Carotid graft interposition
Description: In patients with extensive atherosclerotic carotid disease, when endarterectomy isn't feasible, replacement of the carotid artery with a graft is needed. Graft interposition can be performed either by end-to-end proximal and distal anastomoses in the undiseased common and internal carotid artery with ligation of the external carotid artery, or by side-to-end proximal anastomosis on the origin of the internal carotid artery and end-to-end distal anastomosis on the internal carotid artery with flow preservation in the external carotid artery.

Intervention type: PROCEDURE
Intervention: Carotid graft interposition
Description: In patients with extensive atherosclerotic carotid disease, when endarterectomy isn't feasible, replacement of the carotid artery with a graft is needed. Graft interposition can be performed either by end-to-end proximal and distal anastomoses in the undiseased common and internal carotid artery with ligation of the external carotid artery, or by side-to-end proximal anastomosis on the origin of the internal carotid artery and end-to-end distal anastomosis on the internal carotid artery with flow preservation in the external carotid artery.
Study: NCT06527313

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Movement Mobilization Concept, Exercise and Tape
Description: Mulligan Concept MWM Mulligan Taping Mulligan Self Home Workout

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Sham Movement Mobilization Concept, Exercise and Tape
Description: The technique will be applied to cases in the sham group with only hand contact, without any slippage or rotation in any direction. Then, rigid taping will be applied without any tension or direction, and home exercises will be given.
Study: NCT06731881

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Flexible nasendoscopy
Description: Sinonasal mucosal inflammation using the Flexible Nasendoscopy Endoscopic Lund-Kennedy (LK) Score will also be obtained before Nasal PDT or control swabbing and at 2 weeks (+/-7 days).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: In-person review
Description: On Week 2 (±7 days), the participant will undergo an in-person review conducted in the ENT Outpatient department, 2nd floor Southwark wing, Guy's Hospital by the CI, PI or Co-investigator. During this appointment, concomitant medications and use of post-operative antibiotics will be reviewed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: In-person review
Description: On Week 2 (±7 days), the participant will undergo an in-person review conducted in the ENT Outpatient department, 2nd floor Southwark wing, Guy's Hospital by the CI, PI or Co-investigator. During this appointment, concomitant medications and use of post-operative antibiotics will be reviewed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Telephone Follow-up
Description: On day 30, the research nurse will telephone participants from the ENT research office.~* Review of adverse events/adverse device effects~* Review of concomitant medications~* Signs and symptoms post-surgery~* Nasal washout~* Record any use of post-operative antibiotics, both local and systemic

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Telephone Follow-up
Description: On day 30, the research nurse will telephone participants from the ENT research office.~* Review of adverse events/adverse device effects~* Review of concomitant medications~* Signs and symptoms post-surgery~* Nasal washout~* Record any use of post-operative antibiotics, both local and systemic
Study: NCT06723717

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Daily infusion of dornase alfa
Description: Daily infusion of dornase alfa at a dose of 125 microg/kg as an intravenous bolus until day 14 after SAH
Study: NCT06733610

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: universal allogeneic anti-CD19/BCMA CAR T-cells
Description: A single injection of UCAR T-cells, referred to as universal allogeneic anti-CD19/BCMA CAR T-cells.
Study: NCT06732739

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: percussions with teach-back breathing exercise
Description: patient will receive Teach Back Breathing Exercises like pursed lip breathing, DE breathing and diaphragmatic breathing Teach-back breathing exercises refer to a method of instructing individuals in breathing techniques and then having them demonstrate or teach back the instructions to ensure comprehension and mastery. This educational approach is commonly used in healthcare settings, particularly when teaching patients how to perform various breathing exercises for therapeutic purposes. Patients were informed about the importance of regular chest percussion I will use the clapping technique which provided by cupped hand for 3 minutes in 5 positions of drainage (upper lobes-apical and posterior segment, apical and anterior segment, right upper lobe-posterior segment, left upper lobe-posterior segment, lower lobes- apical segment) with assisted suction three times/shift for four days, and then each patient will be observed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PERCUSSION
Description: similar to Group A, each patient underwent individual interviews. Patients were educated on the significance of regular chest percussion. The clapping technique, executed with cupped hands, was applied for 3 minutes in five drainage positions (upper lobes - apical and posterior segment, apical and anterior segment, right upper lobe - posterior segment, left upper lobe - posterior segment, lower lobes - apical segment). This procedure, including assisted suction three times per shift, was administered for four consecutive days.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PERCUSSION
Description: similar to Group A, each patient underwent individual interviews. Patients were educated on the significance of regular chest percussion. The clapping technique, executed with cupped hands, was applied for 3 minutes in five drainage positions (upper lobes - apical and posterior segment, apical and anterior segment, right upper lobe - posterior segment, left upper lobe - posterior segment, lower lobes - apical segment). This procedure, including assisted suction three times per shift, was administered for four consecutive days.
Study: NCT06733948

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dental stent
Description: Dental stent is personalised device for tongue depressing and immobilisation during RT. The aims are to reduce unnecessary RT doses to adjacent non-target healthy tissue, including the tongue, adjacent oral mucosa, parotid glands/ submandibular glands, and temporomandibular joints. Dentists will take impression of the teeth on moulds, and measure the height to raise the bite, the stent is then fabricated as methyl methacrylate resin in the dental laboratory. The resin base extends to the tongue and a flat plate depresses the tongue. This device will be placed before each RT fraction.

Intervention type: OTHER
Group type: OTHER
Intervention: No dental stent
Description: No dental stent used during chemoradiation treatment
Study: NCT06731972

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercises
Description: Classical massage, stretching, functional exercises, electrical modalities, thermal agents, home exercises, etc., plus home exercises.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercises
Description: Classical massage, stretching, functional exercises, electrical modalities, thermal agents, home exercises, etc., plus home exercises.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Mobile game
Description: mobile application games (such as Temple Run, Flappy Bird, Angry Birds, etc., or games the patient is already playing) as part of their home exercise program.
Study: NCT06733168

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: electrical impedance tomography
Description: Before initiating recruitment maneuver, all patients were placed on mechanical ventilation set according to the ARDSnetwork strategy for 10 minutes, ensuring SpO2 of 88-95%, PaO2 of 55-80 mmHg, and a mean arterial pressure (MAP) ≥ 65 mmHg.~* PEEP was incrementally increased by 5 cmH2O every minute: from 10 to 15, to 20, and finally to 25 cmH2O, with a maximum pressure limit of 40 cmH2O.~* Following recruitment maneuver at the final PEEP level, the process of identifying the optimal PEEP was initiated.~* Then, PEEP will be set to 20 cmH2O and was gradually decreased by 2 cmH2O every 30 seconds until it reached 6 cmH2O or SpO2 dropped to ≤ 80%.~* Selection of optimal PEEP: The optimal PEEP was defined as the intersection point between the alveolar overdistension and collapse curves as measured by the EIT system.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Non-EIT
Description: Patients will have PEEP set using the low FiO2-PEEP table, based on the ARDSnet protocol
Study: NCT06732141

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Personalized Telephone-Based Psychological Support
Description: This intervention involves weekly, individualized 30-minute telephone sessions conducted over 8 weeks. The sessions are designed to address anxiety and improve adherence to inhaled corticosteroid (ICS) therapy in asthma patients. The intervention comprises four core components:~1. Medication Education: Detailed guidance on the benefits, mechanisms, and safety of ICS therapy, aiming to address misconceptions and reduce fears about side effects.~2. Lung Rehabilitation Guidance: Instructions for breathing exercises and tailored physical activity to improve respiratory health and overall well-being.~3. Motivational Interviewing (MI): A patient-centered approach that identifies barriers to adherence, enhances self-efficacy, and motivates behavior change.~4. Progressive Muscle Relaxation (PMR): A systematic relaxation technique to alleviate physical and emotional stress, tailored to each patient's anxiety levels.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Standard Care with Weekly Follow-Up Calls
Description: Participants receive weekly telephone follow-up calls for 8 weeks. These calls include health status assessments, symptom monitoring, and general medication inquiries but exclude psychological or educational components.
Study: NCT06732934

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise (Basic Body Awareness Therapy
Description: Body Awareness Therapy is a patient-centered physiotherapy approach that also includes mental health, focusing on movement awareness training. This therapy primarily consists of exercises aimed at improving postural disorders, balance, and muscle tension. It aims to help individuals experience and accept bodily responses while increasing coping strategies.~The therapy includes body scanning, integration of sound and movement, stretching exercises, and exercises focusing on body alignment and midline orientation.~Floor exercises: body scanning, stretching, strength accumulation, sound resonance.~Seated exercises: body alignment, trunk rotation, head and neck movements. Standing exercises: support surface perception, midline elevation and lowering, bilateral arm movements, rotation, one-legged balance, voice exercises, and group movements.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise (aerobic exercise)
Description: The continuous exercise protocol specified by the American College of Sports Medicine (ACSM) will be applied under supervision on a treadmill. The exercise duration will follow ACSM recommendations, starting at 30 minutes in the first week and increasing to 45 minutes by the 12th week.~Exercise intensity will be assessed using the target heart rate method (220 - age). The intensity of aerobic exercise will be set at a moderate level (64-77% HRmax), according to ACSM guidelines.~During exercise, heart rate will be monitored through a heart rate monitoring device. A 5-minute warm-up and a 5-minute cool-down exercise will be performed before and after each session, with an intensity of 50-60% of the maximum heart rate.
Study: NCT06733805

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Portrait + Therapeutics Letter
Description: In the context of audit and feedback interventions, Portrait is a document produced by the physician organization Therapeutics Initiative that provides personalized prescribing feedback for BC clinicians. Portraits are used as a practice resource tool for reflection on prescribing patterns. Each Portrait topic provides data of individual prescriber's prescribing practice, benchmarks or targets, a succinct review of the best-available evidence on the topic, and recommendations for future action.~The Therapeutics Letter is a standalone publication that details identified problematic therapeutic issues in a brief, simple and practical manner. Therapeutics letters include a systematic literature review on a clinical topic, and provide reference for the data presented in the Portraits.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Portrait + Therapeutics Letter
Description: In the context of audit and feedback interventions, Portrait is a document produced by the physician organization Therapeutics Initiative that provides personalized prescribing feedback for BC clinicians. Portraits are used as a practice resource tool for reflection on prescribing patterns. Each Portrait topic provides data of individual prescriber's prescribing practice, benchmarks or targets, a succinct review of the best-available evidence on the topic, and recommendations for future action.~The Therapeutics Letter is a standalone publication that details identified problematic therapeutic issues in a brief, simple and practical manner. Therapeutics letters include a systematic literature review on a clinical topic, and provide reference for the data presented in the Portraits.
Study: NCT06755073

Intervention type: RADIATION
Intervention: Pulmonary artery Doppler ultrasound
Description: Doppler ultrasound of fetal pulmonary artery
Study: NCT06174584

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Hypertonic saline
Description: Hypertonic saline

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Cow Milk
Description: Cow Milk
Study: NCT06174311

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Active Cognitive Bias Modification
Description: The intervention comprises three sessions and is provided online. Each session consists of two different tasks. To prevent order effects, these tasks will be presented to each participant in a random sequence. One of the tasks involves uncertain scenarios based on a scenario paradigm. At the end of these scenarios, participants will be asked to complete a missing letter in a word that in the scenario, followed by a comprehension question related to the scenario interpretation. Following each question, feedback will be provided regarding the correctness of the response. The other task is a word-sentence pair paradigm, where participants will be asked to assess whether these pairs are related, and feedback will also be provided.
Study: NCT05527379

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Virtual reality
Description: When the patient is ready to have the CIP procedure the tablet will be presented to him so that he can view and choose the immersive film that suits him best.~Before fitting the virtual reality helmet and the start of the film, the patient's anxiety will be evaluated by ENS on a scale of 0 to 10 . The patient's anxiety will also be evaluated at the end of the procedure.~The patient will be contacted by telephone by an investigator between D+1 and D+5 in order to reassess and remotely from the pose, his memorization of the gesture and to look for adverse events.
Study: NCT05920980

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: lidocaine
Description: Patients in the lidocaine groups, lidocaine 1.5mg/kg/h was continuously infused (using ideal body weight) during the whole procedure, postoperative analgesia pump with lidocaine (lidocaine 50mg/kg, sufentanil 2ug/kg, glassetron 12mg), diluted to 200ml with saline until 72h after surgery. Blood samples will be collected from some patients in the lidocaine group for the measurement of lidocaine plasma concentration.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: In the placebo group, the same volume of normal saline will be administered during anesthesia. The postoperative PCIA device will contain sufentanil 2 μg/kg, granisetron 12 mg diluted to 200 mL in 0.9% normal saline solution with a total volume of 200 mL.
Study: NCT05632510

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: The Edinburgh Postnatal Depression Scale (EPDS)
Description: The Edinburgh Postnatal Depression Scale (EPDS) is a self-administered questionnaire of 10 items, is recommended by the NICE guideline and French National Authority for Health for screening peripartum women, validated in French and well accepted.
Study: NCT04918784

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Restrata®
Description: Restrata® is a sterile, single use device intended for use in local management of wounds. Restrata® is a soft, white, conformable, non-friable, absorbable matrix that provides a moist environment for the body's natural healing process to occur. Restrata® is made from synthetic biocompatible materials and was designed to include a fibrous structure with high porosity, similar to native extracellular matrix.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Wound Dressing
Description: Alginate or Foam wound dressing is intended to manage wounds.
Study: NCT06258590

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneous auricular vagus nerve stimulation
Description: Patients will receive non invasive vagus nerve stimulation via electrodes attached to the ear.
Study: NCT05591027

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Centella asiatica product
Description: A sachet of powdered product containing 4 g of a dried hot water extract of Centella asiatica as the active ingredient, combined with inactive ingredients (excipients) for color and taste dissolved in 10 oz of warm or room temperature water and consumed orally.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: A sachet of powdered inactive ingredients (excipients) for color and taste identical in volume to those found in the active arm (CAP) dissolved in 10 oz of warm or room temperature water and consumed orally.
Study: NCT06149793

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Empagliflozin
Description: Sodium glucose co-transporter 2 inhibitor

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Control
Description: Placebo Control
Study: NCT04563221

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Prostatic artery embolization
Description: Prostatic artery embolization is performed using LC Bead LUMI, which is the investigational device. The particles are administered to the prostatic arteries using either a balloon occlusion or standard microcatheter. Follow-up is performed at 1 month, 6 months, 12 months, and 24 months after intervention.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Prostatic artery embolization
Description: Prostatic artery embolization is performed using LC Bead LUMI, which is the investigational device. The particles are administered to the prostatic arteries using either a balloon occlusion or standard microcatheter. Follow-up is performed at 1 month, 6 months, 12 months, and 24 months after intervention.
Study: NCT06263621

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention Standard
Description: The two cafes will offer entrees in two sizes, a smaller and larger size. In the intervention cafe, the smaller size will be labeled Standard during the intervention period, and Small during all other times. In the control cafe, the smaller size will always be labeled Small. The larger size will always be labeled Large for both cafes during the duration of the study.
Study: NCT05888506

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ketone Ester
Description: Participants will consume the ketone ester beverage produced by KetoneAid prior to bedtime. Participants will consume 60 mL (30 grams ketones) of the ketone beverage.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants will consume the placebo supplement prior to bedtime. The placebo supplement will be a ketone ester-free, taste and viscosity-matched, beverage produced by KetoneAid.
Study: NCT06380218

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nutrional and physical activity program
Description: Nutritional prevention and physical activity workshops associated with a substitution of saturated and/or trans fatty acids by cis-unsaturated acids via the consumption of Primevère margarine to influence lifestyle habits, quality of life and improvement of the lipid profile of women with cardiovascular risk
Study: NCT05282797

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ANEB-001
Description: Experimental Treatment