TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04899401

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Standard of care + PediaFlù®
Description: Standard of care: Standard of care for acute tonsillitis / rhinopharyngitis is focused on symptomatic treatment. PediaFlù®: During the 6 days of the clinical investigation, the subjects will administer PediaFlù® 5ml x3 times per day for children below 6 years and 10mlx3 times per day for children above 6 years.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard of care
Description: Standard of care for acute tonsillitis / rhinopharyngitis is focused on symptomatic treatment. Standard of care Nasopharyngeal liberation through hydration with drinking fluids to support body fluid excretion, aspiration of secretions, NaCl solution for nasal irrigation, Nasal sprays with sea water, nasal spray with active compound (to be used only at special indication of the medical doctor) Throat spray with Benzydamine hydrochloride (Tantum Verde®), Pediatric use: children over 6 and below 12: 4 sprays 2 - 6 times a day. Children (under 6 years): 1 spray per 4 kg of body weight, a maximum of 4 sprays at once, 2-6 times a day according to the leaflet. Each spray equals 0.17 ml of solution. Acetaminophen (Paracetamol) per os: at need, as antipyretic (\>38,5C), 10 mg/kg/dose, per need every 6-8 hours or according to the leaflet, maximum dosage 80 mg / kg / day. A dosage of over 30 mg/Kg/dose will result in an IP failure;
Study: NCT04764383

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L-Histidine
Description: 1000 mg capsules taken by mouth (PO) twice daily (BID).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L-Histidine
Description: 1000 mg capsules taken by mouth (PO) twice daily (BID).

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Microcrystalline cellulose (placebo) 1000 mg capsules taken by mouth (PO) twice daily (BID).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Microcrystalline cellulose (placebo) 1000 mg capsules taken by mouth (PO) twice daily (BID).

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Lodosyn
Description: 50 mg capsules taken PO BID.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lodosyn
Description: 50 mg capsules taken PO BID.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lodosyn
Description: 50 mg capsules taken PO BID.
Study: NCT06460337

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Modified Otago exercises
Description: Participants will engage in modified Otago exercise sessions, either individually or in groups, for 45 minutes, thrice weekly over an 8-week period. The program entails moderate-intensity strengthening exercises targeting various muscle groups such as hip extensors, abductors, knee flexors and extensors, inner range quadriceps, ankle plantar flexors, and dorsiflexors, performed at 10 repetitions maximum (RM) with ankle cuff weights ranging from 0.5 to 1 kg. Additionally, balance exercises will be conducted, initially with support and gradually progressing to without support, including knee bends, backwards walking, sideways walking, tandem stance and walk, one leg stance, heel and toe walking, sit-to-stand, stair climbing, stepping over objects, and bending to pick up objects from the floor. Participants are also encouraged to walk outdoors at their usual pace for 30 minutes at least three times weekly.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Frenkel's exercises
Description: Frenkel's exercise regimen comprises a series of movements performed in lying, sitting, stride standing, and standing positions aimed at improving coordination and motor control. In the lying position, exercises include alternating hip and knee flexion/extensions, hip abduction/adduction, pedaling the lower limbs, and simultaneous movements of hips and knees. These are executed slowly to enhance coordination. In sitting, exercises involve leg stretching, hip flexion with knees flexed or straightened, and transitions from sitting to standing and back. Stride standing exercises focus on weight transfer and sideways walking, while standing exercises encompass walking on marked paths, trunk rotations, 360-degree turns, smaller arcs of hip abduction/adduction and flexion/extension, straight-line walking, and directional changes to simulate real-life obstacles. 3 sets comprising 10 repetitions are performed for each exercise, aiming for motor skill improvement and balance enhancement
Study: NCT06385041

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention group 1
Description: Additional exercise program with balance and strength trainings will include 3 times/week. Patients will get an individualized exercise program for frailty syndrome, which will include strength exercises (with elastic resistance bands and weights up to 2kg 30-50% 1RM) and balance training (with unstable surfaces). The program will be performed by 3 sets with 10 repetitions 3 times/week 30-45 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention group 2
Description: Additional exercise program with balance and strength trainings will include 3 times/week 30-45 minutes. Patients will get an individualized program for frailty syndrome, with interactive technologies: gait training with Biodex GaitTrainerTM3 with visual, audio feedback and incline up to 10-15 min, Zebris FDM-T, with virtual barriers, thus simulating real environment for the patient, while performing a cognitive task up to 10-15 min, for balance training we will use a computerized Biodex board. Exercises will be performed with the programs: Postural stability training, Limits of stability training, Weight shift training, Maze control training, Random control training, Percent weight-bearing training. For strength training we will use equipment HUR based on pneumatic (air pressure) technology. For strength training intensity 30-50% 1-RM, 10 repetitions with 3 sets. Leg press, leg extension, leg abduction, leg adduction will be performed with pneumatic technology.
Study: NCT04724096

Intervention type: DIAGNOSTIC_TEST
Intervention: Oxygen Enhanced MRI scan
Description: Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.

Intervention type: DIAGNOSTIC_TEST
Intervention: Oxygen Enhanced MRI scan
Description: Dynamic MRI scanning switching from breathing room air to high concentration oxygen part way through the scan.
Study: NCT05382910

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MG-K10
Description: MG-K10 Humanized Monoclonal Antibody Injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MG-K10
Description: MG-K10 Humanized Monoclonal Antibody Injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT05817474

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: lidocaine (2 %) 2 ml and tranexamic acid
Description: lidocaine (2 %) 2 ml and tranexamic acid 2 ml in each tonsillar bed

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: lidocaine (2 %) 2 ml and tranexamic acid
Description: lidocaine (2 %) 2 ml and tranexamic acid 2 ml in each tonsillar bed
Study: NCT05248698

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: lifestyle change
Description: 30 older patient who will complain from dry eye will receive 3-time interval exercise per the week, applied for 30 min with high intensity, plus Mediterranean Diet for 6 months

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: exercise
Description: 30 older patient who will complain from dry eye will receive 3-time interval exercise per the week, applied for 30 min with high intensity, for 6 months
Study: NCT05038709

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: The Pink Pad Hip Kit
Description: The pad is placed between the patient and the traction table to reduce pressure to the pudendal nerve exerted by the perineal post.
Study: NCT05955677

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [68Ga]Ga-PSMA-D5
Description: Each subject receive a single intravenous injection of \[68Ga\]Ga-PSMA-D5, and undergo PET/CT imaging within the specificed time.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [68Ga]Ga-PSMA-11
Description: Each subject receive a single intravenous injection of \[68Ga\]Ga-PSMA-11, and undergo PET/CT imaging within the specificed time.
Study: NCT06410339

Intervention type: DIAGNOSTIC_TEST
Intervention: Ultrasound
Description: ultrasound of flexor tendons on hands

Intervention type: DIAGNOSTIC_TEST
Intervention: Ultrasound
Description: ultrasound of flexor tendons on hands
Study: NCT06338436

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Proton Radiation Therapy System (ProBeam)
Description: All enrolled subjects will be treated with Proton radiation therapy using the medical device Varian Proton Therapy System (ProBeam). The screening period from informed consent to enrollment is expected to be 2 weeks, while the treatment period depends on patient medical situation and treatment plan. The period after the last treatment is divided into short-term follow-up which is 90 days after treatment completion and long-term follow-up which is 5 years after treatment completion. The clinical trial with short-term follow-up fulfills the requirements for NMPA regulatory registration. All the end points claimed will be achieved in the short-term follow-up stage. The trial is defined as completion once short-term follow-up is finished.
Study: NCT05186896

Intervention type: OTHER
Intervention: Risk perception questionnaire
Description: A questionnaire for risk perception will be developed and administered
Study: NCT05651113

Intervention type: OTHER
Intervention: SCID Screening
Description: The addition of newborn bloodspot screening for severe combined immunodeficiency

Intervention type: OTHER
Intervention: SCID Screening
Description: The addition of newborn bloodspot screening for severe combined immunodeficiency
Study: NCT06108739

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamid
Description: A total of 10mg/kg ATG was administered, and two doses of 14.5 mg/kg Cy were given on days 3 and 4 post-HCT in ATG-PTCy cohort.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ATG
Description: A total of 10mg/kg ATG was administered.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ATG
Description: A total of 10mg/kg ATG was administered.
Study: NCT05651113

Intervention type: OTHER
Intervention: SCID Screening
Description: The addition of newborn bloodspot screening for severe combined immunodeficiency
Study: NCT04698798

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Muscle Biopsy
Description: Patients will be treated for SARS-CoV-2 symptoms on the intensive care unit. During this treatment two muscle biopsies will be obtained with an interval of seven days between them.
Study: NCT05219097

Intervention type: DIAGNOSTIC_TEST
Intervention: CBA Assay
Description: Comparsion of specificity, sensitivity and clinical correlation of CBA, ELISA and RIPA assay in autoantibodies detection of myasthenia gravis

Intervention type: DIAGNOSTIC_TEST
Intervention: CBA Assay
Description: Comparsion of specificity, sensitivity and clinical correlation of CBA, ELISA and RIPA assay in autoantibodies detection of myasthenia gravis

Intervention type: DIAGNOSTIC_TEST
Intervention: CBA Assay
Description: Comparsion of specificity, sensitivity and clinical correlation of CBA, ELISA and RIPA assay in autoantibodies detection of myasthenia gravis
Study: NCT04785560

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Initial shunt setting post-operatively of the Certas Plus shunt valve.
Description: The setting/resistance of the Certas Plus Shunt valve implanted is set according to randomisation and is not changed until the first post-operative MRI is performed 36-48 hours after surgery.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Initial shunt setting post-operatively of the Certas Plus shunt valve.
Description: The setting/resistance of the Certas Plus Shunt valve implanted is set according to randomisation and is not changed until the first post-operative MRI is performed 36-48 hours after surgery.
Study: NCT04822935

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Vertebral Body Tethering
Description: VBT surgery is a surgery performed by thoracotomy in adolescent idiopathic scoliosis patients.
Study: NCT05850104

Intervention type: OTHER
Intervention: the effects of classical Chopart prosthesis on socket comfort, satisfaction level and quality of life in patients with unilateral Chopart amputation.
Description: the effects of classical Chopart prosthesis and silicone prosthesis on socket comfort, satisfaction level and quality of life in patients with unilateral Chopart amputation.

Intervention type: OTHER
Intervention: the effects of silicone prosthesis on socket comfort, satisfaction level and quality of life in patients with unilateral Chopart amputation.
Description: the effects of silicone prosthesis on socket comfort, satisfaction level and quality of life in patients with unilateral Chopart amputation.
Study: NCT05807438

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Self myofascial Release
Description: Myofascial release participants on their own will roll the foam roller in each area for two minutes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: myofascial release
Description: Myofascial release will be applied to the participants by the physiotherapist.
Study: NCT05638516

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Vira mobile app intervention
Description: The Vira app is installed on the participant's phone. The app passively collects data from phone sensors (i.e., measures of physical activity, sleep patterns, mobility, and language patterns reflecting mood states and cognition) that are indicative of risk-relevant behavioral patterns and psychological states. It also so prompts users to answer a daily check in question. Mobile sensing data are processed to provide an automated assessment of the user's functioning. Users will be asked to use Vira for 12 weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Vira mobile app intervention + coaching
Description: The Vira app can also be supported by a health coach. The health coach interacts with the user (via an instant messaging platform) and who also schedules just-in-time reminders (i.e., nudges) to arrive in the user's phone at scheduled times to support their behavior change plan. The Vira Health Coach Platform therefore integrates mobile sensing, self-report assessment, and just-in-time nudges and notifications into the coach's workflow.
Study: NCT03907020

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Barley
Description: Assessing the metabolic availability of lysine in barley.
Study: NCT05382598

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Renal replacement therapy
Description: Renal replacement therapy (RRT) will be initiated in the early group for patients who have stage 2 AKI according to KDIGO classification. The late group will have RRT when they develop any of the absolute indications for RRT

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Renal replacement therapy
Description: Renal replacement therapy (RRT) will be initiated in the early group for patients who have stage 2 AKI according to KDIGO classification. The late group will have RRT when they develop any of the absolute indications for RRT
Study: NCT05411874

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide
Description: 5mg po biw for 24 weeks
Study: NCT05012215

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Paravertebral
Description: Ultrasound-guided paravertebral block

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Caudal block
Description: Caudal block
Study: NCT04781647

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ABI-H0731
Description: Participants will receive ABI-H0731 300 mg tablets orally once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ABI-H0731
Description: Participants will receive ABI-H0731 300 mg tablets orally once daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ETV
Description: Participants will receive ETV 0.5 mg tablets orally once daily
Study: NCT05411874

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HD-DXM
Description: 40mg po qd for 4days

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HD-DXM
Description: 40mg po qd for 4days
Study: NCT06442449

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: sIPV
Description: vaccination with sIPV

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: sIPV
Description: vaccination with sIPV

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: sIPV
Description: vaccination with sIPV

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: MMR
Description: vaccination with MMR

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MMR
Description: vaccination with MMR

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: HepA-I
Description: vaccination with HepA-I

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: HepA-I
Description: vaccination with HepA-I
Study: NCT05462275

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Intubation using 3-cuffed double lumen endotracheal tube
Description: After patient's position, 3-cuffed double lumen endotracheal tube is intubated without fiberoptic bronchoscopy guidance
Study: NCT04937907

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydroxychloroquine Sulfate 100 milligram (mg) Tab
Description: Patients administered HCQ by oral at a dose of 6.5mg per kilogram twice a day at least 6 months.

Intervention type: DRUG
Group type: SHAM_COMPARATOR
Intervention: Benazepril hydrochloride 10 milligram (mg) Tab
Description: Patients administered Benazepril by oral at a dose of 5mg or 10mg once a day at least 6 months.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Benazepril hydrochloride 10 milligram (mg) Tab
Description: Patients administered Benazepril by oral at a dose of 5mg or 10mg once a day at least 6 months.
Study: NCT05735275

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-A2102
Description: All participants receive SHR-A2102 alone.
Study: NCT03972020

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness Based Intervention
Description: The MBI used in this study is called body-affective mindfulness (BAM); BAM is based on:~(1) awareness practices such as body scan, breath meditation, walking meditation and yoga exercises; (2) mindfulness in relationship practices such as loving kindness, enriching listening to nature and persons and self-compassion; (3) sensorimotor psychotherapy Sensorimotor psychotherapy emphasizes the use of somatic resources to attain and sustain a mindful disposition and integrates the concept of a stress response with the concept of a window of tolerance in order to maximize the clinical utility of the intervention and tailor it to breast cancer patients.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Behavioral Therapy
Description: Cognitive behavior therapies will include cognitive restructuring, relaxation, skills training, and visual imagery, among other modalities.
Study: NCT05636072

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: WISER
Description: Participants will engage in one or more positive psychology well-being tool(s).
Study: NCT05993091

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mirror therapy (MT)
Description: Each participant will practice two different MT protocols: UMT and BMT. During UMT, the affected hand is static, whereas during BMT, the affected hand moves in an attempt to duplicate the unaffected hand as best as possible. The MT activities include gross motor movements (i.e., shoulder flexion, elbow flexion/extension, forearm pronation/supination, and wrist flexion/extension and circumduction), fine motor movements (i.e., opposition, grasp, and release), and object manipulation (i.e., reaching out to grasp a cup, flipping coins).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: augmented reality (AR)
Description: The training program with different levels of difficulty provides goal-directed exercises designed to be adjustable in order to match the patient's ability to minimize compensatory movements. The goal-directed exercise includes balance training (i.e., weight shifting, standing on one leg, etc.), activities of daily living training (i.e., reaching to grasp functionally relevant objects), and cognitive enhancement (i.e., memory training). By using the AR system, participants can observe the real performance of motions and interaction between the body and the virtual environment.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: augmented reality (AR)
Description: The training program with different levels of difficulty provides goal-directed exercises designed to be adjustable in order to match the patient's ability to minimize compensatory movements. The goal-directed exercise includes balance training (i.e., weight shifting, standing on one leg, etc.), activities of daily living training (i.e., reaching to grasp functionally relevant objects), and cognitive enhancement (i.e., memory training). By using the AR system, participants can observe the real performance of motions and interaction between the body and the virtual environment.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control intervention
Description: Participants will perform 90 minutes of therapist-mediated conventional therapy. The treatment protocols will be formulated by using occupational therapy techniques, such as neurodevelopmental techniques and functional task training. Specifically, the affected arm exercise or gross motor training, muscle strengthening of the affected arm, fine motor or dexterity training, and functional tasks of daily life or compensatory techniques will be used to alleviate functional deficits. In addition, the therapist will work with the participant to select functionally relevant tasks, such as picking up items from a box, lifting soft drink bottles, hanging clothes, and so on.
Study: NCT06424509

Intervention type: OTHER
Intervention: High degree of long (>5 days) and/or compulsory psychiatric inpatient care
Description: High degree of long (\>5 days) and/or compulsory psychiatric inpatient care
Study: NCT04650126

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ATM001
Description: monovalent anti-TNF-receptor 1 antibody format

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: ATM001 Placebo
Description: ATM001 Placebo