TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04687540

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Tocilizumab
Description: Baseline: Tocilizumab (infusion of 8 mg/kg bodyweight or a maximum of 800 mg) will be infused over 60 minutes at the end for the study day, therefore study visit 1 (study day 1) measurements are baseline.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Saline 0.9%
Description: Participants are under influence of tocilizumab since the effect of the drug will last for 4 weeks. Participants will be infused with saline at study visit 2 (study day 21). Placebo to tocilizumab will be saline (NaCl 0.9%) as tocilizumab is a colorless solution and has to be diluted with NaCl 0.9% prior to administration
Study: NCT06163014

Intervention type: BEHAVIORAL
Intervention: My Symptoms eHealth programme
Description: My Symptoms supports patients' self-efficacy and behavioural changes. The programme is activated by the patient after prescription by the GP. The patient is free to choose relevant tasks corresponding to wishes, needs/requirements and own perspectives.~Summary of content:~1. Symptom explanations and facts about frequent symptoms including brief animated explanations~2. Physical energy (sleep, diet and activity)~3. Working with resources and strain in everyday life~4. Values and choices (meaning and existential issues)~5. Thoughts~6. Feelings (emotion regulation)~7. Self-care (attention incl. mindfulness and audio exercises)~8. Preparation for a follow-up visit with the GP and relapse prevention. The above modules connect to four general tools: symptom registration, 'don't break the chain', goal setting staircase and notebook.~After 6 weeks: Voluntary GP follow-up consultation. After 8 weeks: End-of-treatment.
Study: NCT04829617

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PP-MI Intervention
Description: The 12-week PP-MI intervention focuses on enhancing well-being (through PP) and promoting adherence to physical activity, diet, and medications (through MI). Each week, participants will complete a PP activity and work towards one or more health behavior goals, then complete a phone session with a study trainer. The PP portion of the program will focus on the cultivation of well-being through the performance of easy-to complete activities (e.g., using a strength in a new way) and review of the positive feelings they generate. The MI portion of the program will focus on assisting participants to monitor health behavior adherence, resolve ambivalence to behavior change, set realistic health behavior goals, problem-solve barriers, and identify resources to complete behavior change. Finally, participants will receive twice weekly text messages (for 24 weeks) to encourage completion of PP activities and engagement in health behaviors.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: MI-alone Intervention
Description: The time- and attention-matched MI-alone intervention focuses on providing education about heart failure (HF) and promoting adherence to physical activity, diet, and medications. Each week, participants will independently complete an activity related to HF education or adherence to a health behavior, then complete a phone session with a study trainer. HF educational topics will include the causes and types of HF, risk factors for cardiovascular disease, methods for monitoring risk factors and symptoms, and the importance of adherence to physical activity, diet, and medications. For each health behavior, study trainers will assist participants to monitor adherence, identify realistic behavior goals, problem-solve barriers, and identify resources to complete behavior change. Finally, participants will receive twice weekly text messages (for 24 weeks) that provide education and encourage engagement in health behaviors.
Study: NCT05742074

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Faecal microbiota transplantation
Description: 25-30 capsules of faecal material

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 25-30 placebo capsules
Study: NCT04866082

Intervention type: OTHER
Intervention: questionnaire
Description: Members of European Society of Intensive Care and European Society of ANaesthesiology and Intensive care will obtain an electronic survey regarding their routine clinical practice of systemic corticosteroids administration among patients with COVID-19 ARDS
Study: NCT06483295

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Using mobile internet platforms for follow-up management of postoperative symptoms in lung cancer patients.
Description: Using mobile internet platforms for follow-up management of postoperative symptoms in lung cancer patients.
Study: NCT05971264

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Near infrared-spectroscopy
Description: Comparison of regional intestinal oxygen saturation (measured with near infrared-spectroscopy) and indirect intraabdominal pressure measurement (bladder pressure) in muscle-relaxed, sedated patients compared to awake, non-sedated patients.
Study: NCT05567471

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: BBV154 Intranasal Vaccine
Description: Administered BBV154 vaccine in form of drops (0.5 mL) via intranasal route

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: BBV154 Intranasal Vaccine
Description: Administered BBV154 vaccine in form of drops (0.5 mL) via intranasal route

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Intramuscular vaccine COVAXIN
Description: Administered BBV152 vaccine via intramuscular route

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Intramuscular vaccine COVAXIN
Description: Administered BBV152 vaccine via intramuscular route

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Covishield
Description: Administered vaccine via intramuscular route
Study: NCT06479408

Intervention type: OTHER
Group type: OTHER
Intervention: progressive muscle relaxation (PMR) technique and vestibular rehabilitation exercises
Description: A will be treated by progressive muscle relaxation (PMR) technique as a mean of stress relaxation and vestibular rehabilitation exercises for postural stability through Swiss ball, BOSU ball, balance board etc. Other components of vestibular rehab including gaze stability enhancement, improvement in vertigo and activities of daily living will also be focused.

Intervention type: OTHER
Group type: OTHER
Intervention: virtual reality (VR)
Description: virtual reality (VR) based intervention program where three dimensional-3D environments will be used reduce stress and improve balance. A Simulator Sickness Questionnaire (SSQ) will be filled by participants before and after each session of VR to discriminate whether VR is provoking the symptoms or not.
Study: NCT06463197

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self-Administered Acupressure Group
Description: Subjects will attend two weekly 120-minute of self-administered acupressure training according to the group allocation in a classroom at the School Nursing, the Hong Kong Polytechnic University. The subjects will be trained to perform self-administered acupressure by an acupuncturist. To enhance interaction and ensure the quality of teaching, each class will be conducted in a small group of 5 to 7 subjects. Participants in this group will learn the self-acupressure technique and passed fidelity check. The treatment protocol included 6 acupoints, namely, Baihui (GV20) and bilateral Fenchi (GB20), Neiguan (PC6), Shenmen (HT7), Shenxu (BL23) and Yongquan (KI1) (Table 1). Subjects were given an acupressure log to record their practice at home, and they were phoned twice a week to remind their practice during the 4-week treatment period.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Sleep Hygiene Education group
Description: The participants in this group will receive education on sleep hygiene. The treatment duration, frequency, and telephone follow-up schedule for the SHE group will be the same as the self-administered acupressure group (2 sessions, 2 hours each). Sleep hygiene education is often used as a comparison group in randomized controlled trials of self-help and psychological interventions for insomnia. The SHE group will provide subjects with the same amount of contact hours with the healthcare professional (instructor) in order to control the non-specific effects of practitioner-patient interaction in the self-administered acupressure group.
Study: NCT05680662

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: quercetin, EGCG, metformin , zinc
Description: this intervention target many mechanisms at tumorigenesis, metastasis autophagy, apoptosis, interleukin 6, cathepsin L, and also epigenetic DNA methylation

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: quercetin, EGCG, metformin , zinc
Description: this intervention target many mechanisms at tumorigenesis, metastasis autophagy, apoptosis, interleukin 6, cathepsin L, and also epigenetic DNA methylation
Study: NCT04893681

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fluoridated bottled drinking water
Description: Study participants are asked to consume study water, as frequently and in amounts as necessary or desired, whenever they drink water (e.g., as plain water or mixed with other ingredients) or use water in food preparation.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Non-fluoridated drinking water
Description: Study participants are asked to consume study water, as frequently and in amounts as necessary or desired, whenever they drink water (e.g., as plain water or mixed with other ingredients) or use water in food preparation.
Study: NCT05802303

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 17-beta Estradiol gel 0.06% w/w(ESTOGEL.Intas pharma)
Description: In the Estradiol gel group patients will be administered transdermal Estradiol gel (17-beta Estradiol gel 0.06% w/w) 2 puffs thrice a day (each application contains 1.25 mg with 0.75 mg of the drug).

Intervention type: DRUG
Group type: OTHER
Intervention: Estradiol Hemihydrate(Estrabet Tablet, abbott pharma)
Description: In the oral Estradiol group, all women will be given 2 mg of Estradiol valerate tablets, one tablets thrice a day within 30 days of injection triptorelin depot. Endometrial assessment will be performed on D10 of HRT. Please see the flow diagram (in the annexure) for details.
Study: NCT06788080

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BioRBC
Description: Autologous biotin-labeled RBCs will be transfused to study participants
Study: NCT04319653

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dynamic pelvic MRI with intravaginal probe with pressure sensor
Description: Dynamic pelvic MRI with intravaginal probe and intravaginal and intrarectal opacification gel
Study: NCT06510907

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: mindfulness based stress reduction program
Description: Mindfulness training will be delivered through a generic 8-week MBSR. The MBSR will consist of weekly 2-hour classes, in which the techniques to various meditations (e.g., body scan, mindful awareness of breathing, body, sounds, thoughts, emotions, and mindful movements) will be taught and discussed. Participants will be asked to meditate for ≥40 minutes every day during the 8-week program as homework. Besides cultivating attention control and a non-judgemental stance to experience, psychoeducation about psychological stress and stress response will also be discussed during the MBSR classes. The MBSR teacher will discuss any difficulties encountered during homework meditations in every class to enhance adherence.~Each MBSR class can have up to 25 participants. The 8-week program will be taught by a qualified MBSR teacher
Study: NCT05853029

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Combined shockwave therapy & conventional therapy , focused shockwave therapy& conventional therapy , conventional therapy
Description: The device used for management is from Storz-Medical company; Duolith-SD1 with focused and radial module.~- Conventional therapy in the form of eccentric exercises, stretching, hot packs and deep transverse friction(Johnson et al., 2007).

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Combined shockwave therapy & conventional therapy , focused shockwave therapy& conventional therapy , conventional therapy
Description: The device used for management is from Storz-Medical company; Duolith-SD1 with focused and radial module.~- Conventional therapy in the form of eccentric exercises, stretching, hot packs and deep transverse friction(Johnson et al., 2007).

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Combined shockwave therapy & conventional therapy , focused shockwave therapy& conventional therapy , conventional therapy
Description: The device used for management is from Storz-Medical company; Duolith-SD1 with focused and radial module.~- Conventional therapy in the form of eccentric exercises, stretching, hot packs and deep transverse friction(Johnson et al., 2007).
Study: NCT05333796

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: gait with leg length discrepancy
Description: After attaching the surface electromyography(EMG) to bilateral back muscles, participants walk at a comfortable speed. The investigators will evaluate the effects of leg length discrepancy on the back muscle activation during gait.
Study: NCT05447156

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Tailored QuitGuide app
Description: This is an app not available to the public. It was developed/tailored based on an app available to the public and can be downloaded.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tailored QuitGuide app
Description: This is an app not available to the public. It was developed/tailored based on an app available to the public and can be downloaded.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Standard QuitGuide app
Description: This is an app available to the public.
Study: NCT05905081

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: aerobic exercise
Description: 30-minutes aerobic exercise intervention on the bicycle ergometer. The exercise protocol includes 5 minutes of warm-up, 20 minutes of loading and 5 minutes of cool-down. The intensity of the exercise will be adjusted to be between 46% and 63% of the VO2max calculated according to the exercise programming guide published by the American College of Sports Medicine (ACSM), and the perceived effort level on the Borg scale will be 12-13. Warm-up and cool-down periods will be set to 46% of VO2max and Borg perceived exertion level below 9.
Study: NCT06316596

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Spinal Anesthesia
Description: Near infrared spectroscopy , neonatal peripheral oxygen saturation measurements and hemodynamic data will be compared between groups

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Epidural Anesthesia
Description: Near infrared spectroscopy , neonatal peripheral oxygen saturation measurements and hemodynamic data will be compared between groups
Study: NCT05777538

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: hydrotherapy
Description: Hydrotherapy will be performed by immersing the women's foot in a container filled with 3 liters water with a temperature of 30-32°C. The water level must cover the women's feet up to ankle. During the immersion the therapist will ask the women to perform exercise with legs being fully supported, then alternatively stretch and flex the ankle for 30 times. which will be followed by circling each foot at ankle in clock wise and anticlock wise direction, 30 times each. The duration of water immersion session will be (30 min) for 5 consecutive days.
Study: NCT06373055

Intervention type: OTHER
Intervention: neoadjuvant chemotherapy followed by radical cystectomy
Description: combination of dose-dense methotrexate, vinblastine, doxorubicin, and cisplatin (ddMVAC) or combination of gemcitabine and cisplatin (GC) followed by radical cystectomy
Study: NCT06787417

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Restricted Kinematically-aligned Arthroplasty
Description: Robot Assisted with Restricted Kinematically-Aligned TKA.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mechanically-Aligned Arthroplasty
Description: Robot Assisted with Mechanically Aligned TKA.
Study: NCT06786988

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: brain MRI scan: (1) one day before the procedure, (2) 24-36 hours after the procedure and (3) up to 1 year after the procedure
Study: NCT05777538

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: foot exercises
Description: The therapist will ask the women to perform exercise with legs being fully supported, then alternatively stretch and flex the ankle for 30 times. which will be followed by circling each foot at ankle in clock wise and anticlock wise direction, 30 times each.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: foot exercises
Description: The therapist will ask the women to perform exercise with legs being fully supported, then alternatively stretch and flex the ankle for 30 times. which will be followed by circling each foot at ankle in clock wise and anticlock wise direction, 30 times each.
Study: NCT06783153

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rifaximin 550 MG
Description: Oral Rifaximin 550mg twice daily from the start of pelvic radiotherapy, with or without chemotherapy, as a preventive measure, and continuing every day until the end of the treatment up to 5 to seven weeks.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Standard Care Chemoradiation
Description: Patients will receive standard chemotherapy and/or radiation
Study: NCT06485245

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CS060304
Description: Tablets administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CS060304
Description: Tablets administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CS060304
Description: Tablets administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CS060304
Description: Tablets administered orally
Study: NCT06456372

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital Health Intervention Group
Description: Our digital health intervention (DHI) uses Patient-Centered Digital Healthcare Technologies (PC-DHT) to promote co-regulation (child/parent), capture patient data, support efficient healthcare delivery, enhance patient engagement, and facilitate shared decision-making, thereby improving access to timely and targeted mental health intervention for children at great risk for poor outcomes. This system will integrate treatment across multiple points of care and will enable health care providers and caregivers to share reliable and targeted information that will facilitate collaborative decision-making (e.g., making decisions about changing or titrating medications/dosages or shifting behavioral therapy and educational intervention targets) and improve patient experiences and outcomes.
Study: NCT05330507

Intervention type: OTHER
Intervention: Wellinks
Description: 30-day post-discharge period: virtual respiratory therapist sessions twice per week with synchronous virtual pulmonary rehabilitation and educational materials; at-home use of connected spirometer and pulse oximeter; at-home use of mobile app.~12-week intensive period: virtual health coaching sessions once every two weeks; asynchronous virtual pulmonary rehabilitation program; ongoing access to connected devices (spirometer and pulse oximeter) and mobile app.
Study: NCT06094374

Intervention type: BEHAVIORAL
Intervention: observation of physical activity behavior
Description: An observational study will be conducted to gather data on multiple levels aiming to identify diverse digital phenotypes related to PA behavior among community-dwelling older adults.~A hybrid approach will be employed, combining both cross-sectional and longitudinal data collection methods. The overall aim is to employ data analysis to identify patterns of PA - behavior (referred to as phenotypes) and to pinpoint prognostic factors that affect PA outcomes.~This integrated strategy will be complemented by four distinct measurement approaches, ensuring a comprehensive assessment of the research objectives. These measurement approaches include:self-reporting, clinical, ecological momentary and time series assessment.
Study: NCT06485245

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CS060304
Description: Tablets administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CS060304
Description: Tablets administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CS060304
Description: Tablets administered orally
Study: NCT00609544

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rilonacept
Description: Loading dose of 320 mg Rilonacept or placebo followed by 160 mg Rilonacept or placebo once a week for 11 weeks

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Rilonacept
Description: Loading dose of 320 mg Rilonacept or placebo followed by 160 mg Rilonacept or placebo once a week for 11 weeks
Study: NCT05387967

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sacubitril/valsartan
Description: All the recruited patients were prescribed Sacubitril/Valsartan at a starting dose of 50 (24/26) mg BID which was up-titrated, over the period of initial 6 weeks, to the maximum tolerated dose up to 200 (97/103) mg BID and further followed for a total of 12 weeks.
Study: NCT05948969

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Decision support
Description: This implementation strategy will include the clinician education of the previous arm and apply audit and feedback of prior care to inform recommendations for future care. These suggestions will encompass 5 different domains based on eligibility and potential opportunity for an SGLT2i, GLP-1RA, angiotensin converting enzyme inhibitors (ACEi)/angiotensin-receptor blockers (ARB), antiplatelet or antithrombotic therapy, and statin therapy. The incorporation of clinical decision support technology will be utilized to identify tailored opportunities for each CV risk reduction based on guideline recommendations for individual patients. Clinicians will be presented prompts with patient-specific recommendation(s) for further optimization of cardioprotective agents. These prompts will be conveyed by a Study Coordinator to responsible clinicians. The follow-up clinical prompts will be based on auditing of updated clinical parameters and medication use.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Facilitated referral to a cardiometabolic team-based center
Description: Each site will have access to clinicians caring for patients in structured, multidisciplinary cardiometabolic centers. Clinicians caring for patients randomized to this intervention strategy will receive a facilitated referral via the EHR together). If the clinician approves the referral, the patient will be referred to this local team-based comprehensive risk factor management clinic. All patients randomized to this group will be considered in this group whether or not a visit to the cardiometabolic center is completed.
Study: NCT06432101

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Acupuncture combined with oral hydroxychloroquine sulfate tablets
Description: Acupuncture combined with oral hydroxychloroquine sulfate tablets