TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05668689

Intervention type: OTHER
Group type: OTHER
Intervention: Preliminary testing
Description: The pilot test will be administered by local investigators via a computer-based application to 35-50 trainees and consultants. The cohorts will include an equal number of trainees and consultants of varying experience, based on the new RCOA curriculum and the extent of their regional experience (stage 1 (CT1-3); stage 2 (ST4-5); stage 3 (ST6-7); stage 3 + regional fellowship trained; consultant; consultant with special interest in regional; consultant + regional fellowship trained). The pilot test will contain short video clips and images of ultrasound guided regional anaesthesia with questions in a constructed response question (CRQ) format to identify relevant structures, anatomy and clinical knowledge.

Intervention type: OTHER
Group type: OTHER
Intervention: Psychometric main study testing (Phase 5)
Description: The main study assessment tool will be administered to trainees of all levels and consultants, aiming to recruit an equal number across different stages of the RCoA curriculum and of varying regional anaesthesia experience (stage 1; stage 2; stage 3; stage 3 + regional fellowship trained; consultant; consultant with special interest in regional; consultant + regional fellowship trained). The exam will consist of constructed response questions (CRQs), which will require the participant to write free-text responses to questions, in line with RCoA examinations.
Study: NCT05685771

Intervention type: DEVICE
Group type: OTHER
Intervention: Phase-targeted auditory stimulation
Description: Bursts of pink noise (50 ms) played during deep non-REM sleep at specific phases of sleep slow waves.
Study: NCT06258681

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Incentive spirometer
Description: The incentive spirometry group will continue training with Volumetric Triflo. It is asked to exhale at first and then hold their breath for at least 3 seconds after taking as deep a breath as possible.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Individualized respiratory training group
Description: Participants will be able to practice both inspiratory and expiratory respiratory muscle training in a single breathing cycle.
Study: NCT06545474

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: bilateral theta burst stimulation
Description: Each stimulation session consists of 600 stimuli applied in bursts of 3 pulses at 50 Hz, with an interstimulus interval of 200 ms. iTBS is administered 20 times for 2 seconds to the left dlPFC, with an intertrain interval of 8 seconds and cTBS continuously for 40 seconds to the right dlPFC in alternating order.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: SSRI treatment
Description: Participants receive 4 weeks SSRI treatment with escitalopram (10mg/day) as standard drug.
Study: NCT06563401

Intervention type: OTHER
Intervention: prognosis of adult-onset t1d
Description: We are comparing mortality and vascular outcomes in adult-onset T1D to T2D and diabetes-free people

Intervention type: OTHER
Intervention: prognosis of adult-onset t1d
Description: We are comparing mortality and vascular outcomes in adult-onset T1D to T2D and diabetes-free people

Intervention type: OTHER
Intervention: prognosis of adult-onset t1d
Description: We are comparing mortality and vascular outcomes in adult-onset T1D to T2D and diabetes-free people
Study: NCT05275244

Intervention type: DEVICE
Intervention: KD Intra-Articular® gel
Description: Depending on the joint, 3 injections will be administrated to the patient: KD Intra-Articular® gel 2.2% - 44 mg in 2 ml - (Pronolis® HD one 2.2%) in the case of shoulder and hip, or KD Intra-Articular® gel 1.6% - 16 mg in 1 ml - (Pronolis® HD mini 1.6%) in the case of the ankle and base of the thumb. The administration of the infiltrations will be with an interval of one week.
Study: NCT05020522

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Luminal Index MRI (LI-MRI)
Description: Multiecho T2 sequence; eventual biopsy of lesion(s) detected with LI-MRI only.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: LI-MRI targeted prostate biopsy
Description: Biopsy targeted to suspicious lesions detected with LI-MRI only

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Plasma methylation signature (ctMethSig)
Description: Blood sample.
Study: NCT04648241

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TBE vaccine 0.5 mL
Description: TBE vaccine 0.5 mL (intramuscular injection).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TBE vaccine 0.25 mL
Description: TBE vaccine 0.25 mL (intramuscular injection).
Study: NCT04474379

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Strategy Training (Time- and Event- Based)
Description: In time-based training, strategic clock-checking behavior is taught by requiring participants to click a button to reveal the virtual time of day. Event-based training involves implementation intention methods.
Study: NCT05151965

Intervention type: PROCEDURE
Intervention: Bankart Repair and Remplissage
Description: Arthroscopic Bankart repair with a minimum of 3 anchors~1 or 2 anchor Remplissage subsequently performed with percutaneous anchor insertion in the base of the Hill-Sachs defect, and sutures passed in a horizontal mattress configuration 1 cm apart, tied in the subacromial space.

Intervention type: PROCEDURE
Intervention: Latarjet Coracoid Transfer
Description: Coracoid transfer performed via deltopectoral approach with horizontal subscapularis split. Graft placed in the conventional orientation, secured with 2 screws, ensuring the graft is not lateral to the glenoid rim.
Study: NCT05865249

Intervention type: OTHER
Group type: OTHER
Intervention: Spirometry decision support software (ArtiQ.Spiro)
Description: ArtiQ.Spiro is a decision support software that combines two sub-components - one focussing on quality assessment (ArtiQ.QC), and one on spirometry interpretation (ArtiQ.PFT). It is intended to be used as an adjunct to spirometry to assist with the grading of spirometry quality and the interpretation of spirometry by providing the probability of six disease / or no disease categories.
Study: NCT06237127

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Goji berry
Description: Participants will be instructed to consume 28 grams of goji berries 5 days a week for 6 months

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Fiber
Description: Participants will be instructed to consume the fiber supplements 5 days a week for 6 months
Study: NCT06178913

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise intervention
Description: The exercise intervention method is a circuit training method that combines strength training and aerobic exercise forms and consists of a total of 12 movements. Performing movements 1 to 12 in order is 1 set. After completing the set, when the heart rate returns to the plateau (less than 59% of maximum heart rate), proceed to the next set, for a total of 3 sets.
Study: NCT06455254

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Candonilimab (AK104)
Description: Cadonilimab (AK104): 6mg/kg, i.v. q2w.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Regorafenib
Description: Regorafenib: 80 mg p.o. qd for 3 weeks of every 4 week cycle (i.e. 3 weeks on, 1 week off).
Study: NCT05357170

Intervention type: OTHER
Intervention: Human feces collection
Description: Human feces collection and blood sampling

Intervention type: OTHER
Intervention: Human feces collection
Description: Human feces collection and blood sampling

Intervention type: OTHER
Intervention: Human feces collection
Description: Human feces collection and blood sampling

Intervention type: OTHER
Intervention: Human feces collection
Description: Human feces collection and blood sampling
Study: NCT05664815

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Human Amniotic Membrane
Description: After conventional/standard treatment, hAM will be applied in a single layer against the bone defect with, if possible, a burial of a few millimeters under the mucous edges.~With the idea of apprehending a possible dose effect, the hAM will be adapted to the size of the bone/mucous defect, mesenchymal side against the bone.~For closure after hAM grafting : 2 options are possible:~Edge-to-edge closure if sufficient mucosal laxity, Edge rapprochement by cross points. If necessary: possible incision of the periosteum to give laxity to the mucosa.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional/Standard treatment
Description: Surgical procedure: Endo-oral approach:~* Trimming of the mucous edges if they are necrotic or inflamed (granulation tissue)~* For the bone: either simple sequestrectomy (the mobile sequestered bone is grabbed using forceps); either reaming until bleeding is obtained; either resection with the rongeur; either monobloc resection of the entire necrotic fragment with a saw or with a piezzotome (ultrasound); or a combination of different techniques. Rq: the resection of the necrotic bone (according to the practices of the center) will operate until the appearance of an apparently healthy bone (bone bleeding, clean appearance of the bone site)~* Closure of the mucosa with possible incision of the periosteum to provide laxity: Suture points by points separated in one plane with non-absorbable braided thread of the 3.0 silk thread type and round needle.
Study: NCT06053450

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Oil Inhalation Patch
Description: Each participant will wear a patch for a work week (3 worked shifts) and then no patch is worn for a week. This alternates for a total of a month.
Study: NCT04755478

Intervention type: PROCEDURE
Intervention: Thoracotomy
Description: Participants will undergo lobectomy via open thoracotomy at the discretion of the surgical team.

Intervention type: PROCEDURE
Intervention: VATS
Description: Participants will undergo lobectomy via VATS at the discretion of the surgical team.
Study: NCT04983511

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Electrical Epidural Stimulation Test (EST)
Description: EST measures sensory/motor responses
Study: NCT05769595

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: MK-2060
Description: Lyophilized powder diluted in normal saline for IV infusion

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV infusion
Study: NCT05071066

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: ADHD+
Description: The group-based intervention is designed to reduce participants' ADHD and related symptoms. The content of the treatment will follow an established manual which is developed by an expert group comprised of psychiatrists and clinical psychologists. Core treatment components include internet use/addiction intervention, cognitive training, emotion management, social skills training, occupational training, emotion support/befriending, parenting training, and career guidance.~The main intervention lasts for 3 months, and the booster intervention lasts for another 3 months. The post- intervention assessments (3-month \[T1\], and 6-month \[T2\]) will be administered to all participants. During the period of intervention, all participants shall be clean from other forms of interventions to reduce any other possible confounders.

Intervention type: OTHER
Group type: OTHER
Intervention: ADHD+
Description: The group-based intervention is designed to reduce participants' ADHD and related symptoms. The content of the treatment will follow an established manual which is developed by an expert group comprised of psychiatrists and clinical psychologists. Core treatment components include internet use/addiction intervention, cognitive training, emotion management, social skills training, occupational training, emotion support/befriending, parenting training, and career guidance.~The main intervention lasts for 3 months, and the booster intervention lasts for another 3 months. The post- intervention assessments (3-month \[T1\], and 6-month \[T2\]) will be administered to all participants. During the period of intervention, all participants shall be clean from other forms of interventions to reduce any other possible confounders.
Study: NCT05486208

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3844583
Description: Administered SC and/or IV.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3844583
Description: Administered SC and/or IV.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3844583
Description: Administered SC and/or IV.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered SC and/or IV.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered SC and/or IV.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered SC and/or IV.
Study: NCT04989530

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Extracorporeal Shock Wave Therapy
Description: different energy levels of ESWT

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Extracorporeal Shock Wave Therapy
Description: different energy levels of ESWT
Study: NCT05415527

Intervention type: OTHER
Group type: OTHER
Intervention: Presence of sarcopenia evaluated prior to neoadjuvant chemotherapy and during chemotherapy as part of optimised management(dietician and APA).
Description: Sarcopenia will be evaluated by CT-scan. This method will be combined with a bone mineral density test which is also a way of entering into a more specific approach to sarcopenia screening.~The patients will receive optimised treatment by nutritional monitoring and adapted physical activity (APA) in addition to follow-up for sarcopenia.
Study: NCT04989530

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Extracorporeal Shock Wave Therapy
Description: different energy levels of ESWT
Study: NCT05794919

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Calcium Hydroxybenzene Sulphonate Dispersible Tablets 0.25g
Description: A generic product manufactured by Hainan Linheng Pharmaceutical Co., Ltd.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Calcium Hydroxybenzene Sulfonate Tablets（Doxium®) 250mg
Description: Calcium Hydroxybenzene Sulfonate Tablets（Doxium®）produced by OM pharma S.A.
Study: NCT06308081

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Tailored
Description: Messages will be in the form of high-quality English-language anti-vaping messages comprising static text and imagery designed to resemble social media posts (e.g., image and a caption). We will create 24 messages based on the top-ranked tailoring features and belief themes tested in Aim 2 to comprise SGM-tailored messages. For the non-tailored message condition, we will create 24 anti-vaping social media messages that mirror the SGM-tailored messages but do not contain SGM identity cues. We will match the belief themes used in the tailored and non-tailored messages such that they represent a range of belief targets (e.g., addiction, physical health effects, mental health effects) as indicated in Aims 1 and 2. We do not utilize a social media platform for the delivery of the message to avoid potential contamination across randomized conditions.
Study: NCT06667128

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rapid Uptitration of Guideline-Directed Medical Therapy
Description: Rapid up-titration of GDMT guided by protocol-specific guideline.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Elecsys® NT-proBNP - Roche Diagnostics
Description: An assay provided by Roche (Elecsys® NT-proBNP - Roche Diagnostics) will be used to assess NT-proBNP levels in the Rapid Up-Titration GDMT Group with Point-of-Care (PoC) Monitoring, with the purpose of evaluating any differences in marker dosage between the indicated method and the monitoring by the hospital laboratory analysis.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rapid Up-Titration GDMT Group with Hospital Monitoring
Description: Rapid Up-Titration GDMT Group guided by protocol-specific guideline and hospital monitoring.
Study: NCT06661759

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Clinic-based and technology-supported sleep intervention
Description: CATS sleep intervention: The in-person sleep education and consultation will consist of 3 face-to-face, one-on-one sessions held 3 months apart during the child's routine clinic visit.The digital component of the sleep intervention will extend in-person education by providing ongoing support. Participants will receive one digital session per week for four weeks after the baseline, 3-month, and 6-month clinic visits, totaling 12 sessions.
Study: NCT05910463

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: AXOMOVE Therapy Medical Device
Description: Personalized exercise programs for the self-rehabilitation of low back pain patients
Study: NCT06667804

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Laughter yoga
Description: Laughter yoga was applied to the experimental group for 4 weeks, 2 days a week, for 8 sessions (each session duration is 30-45 minutes on average). - The researcher is certified as an International Leader of Laughter Yoga. As a nursing intervention, patients with T2DM were made to do laughter yoga by the researcher. The laughter yoga program was conducted online (Google meet online) due to the ongoing COVID-19 pandemic at the time of the study. - The sessions were organized as follows: Monday-Thursday 10:00-10:45, Tuesday-Friday 10:00-10:45, Wednesday-Saturday 10:00-10:45. Participants participated in two sessions that were suitable for them within a week. A participant in a group was not allowed to change days in the following weeks.
Study: NCT06668870

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Supplemental Text Messaging
Description: Will receive education about the collection of patient-generated data, training in using the data collection tools, and guidance on the standard frequency for collection and sharing of information. Supplemental text messages will be sent to engage patients and deliver personalized reminders to complete monitoring tasks.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Education and Training for Patient-Generated Data
Description: Will receive education about the collection of patient-generated data, training in using the data collection tools, and guidance on the standard frequency for collection and sharing of information.
Study: NCT06672640

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Remote Exercise Program
Description: Participants in this group will engage in an eight-week exercise program conducted via video conferencing software. The sessions, which focus on balance, lower limb strength, and gait function, will be held twice weekly for 50 minutes each. Licensed physical therapists will supervise the sessions, and participants will exercise at home, with assistance from caregivers if necessary. The program aims to evaluate the effectiveness of remote exercise interventions in improving physical function and reducing the risk of falls in pre-frail older adults.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: In-Person Exercise Program
Description: Participants in this group will take part in an eight-week in-person exercise program at a senior welfare center. The sessions will be held twice weekly for 50 minutes and will be led by a licensed physical therapist. The exercise program, which includes balance, lower limb strength, and gait training, is identical to that of the remote exercise group, with the primary difference being the mode of delivery (in-person at the welfare center). This group aims to assess the effectiveness of direct supervision in a controlled environment.

Intervention type: OTHER
Group type: OTHER
Intervention: Physical Activity Education
Description: Participants in this group will receive educational materials about physical activity, including a booklet and one educational session. They will not participate in any structured exercise program but will be encouraged to maintain their usual activities. The control group serves as a baseline to compare the outcomes of exercise interventions against no structured exercise, focusing on evaluating usual care versus targeted exercise programs.
Study: NCT05319535

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Implementation Strategy: Foundational REP
Description: Among Caregivers FIRST sites that do not meet implementation adoption benchmarks, the goal is to test implementation intensification approaches, specifically Foundational REP vs. Enhanced REP. The investigators propose that low intensity implementation support that promotes adapting Caregivers FIRST for context and provides tools for ongoing Caregivers FIRST evaluation (defined as foundational REP), will be sufficient for some but not all sites to successfully incorporate Caregivers FIRST into routine practice.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Implementation Strategy: Enhanced REP
Description: Among Caregivers FIRST sites that do not meet implementation adoption benchmarks, the goal is to test implementation intensification approaches, specifically Foundational REP vs. Enhanced REP. The investigators posit that higher intensity strategies (defined as Enhanced REP) that directly influence teams' capacity and skills to effectively self-organize and problem-solve will lead to higher implementation adoption, penetration, fidelity, and value.
Study: NCT04333290

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [11C]MeDAS
Description: PET radiotracer
Study: NCT06489678

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Robotic Assisted Bronchoscopy
Description: Cone-beam computed tomography (CBCT) technology and robotic-assisted bronchoscopy (RAB) present promising methods to enhance biopsy accuracy and procedural safety through 3-dimensional reconstructions and increased bronchoscope tip flexibility. Additionally, the transfer of navigational data between CBCT and RAB may further improve diagnostic yield. Given their distinct approaches to enhancing diagnostic outcomes, two separate study arms are warranted for CBCT and RAB.
Study: NCT05188235

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Acoustical Resonance Device
Description: Infants will be studied for 15 min using an electronic tuning fork to transmit sound through the hip from a point on the skin while transmitted sounds FDA-approved stethoscope

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Acoustical Resonance Device
Description: Infants will be studied for 15 min using an electronic tuning fork to transmit sound through the hip from a point on the skin while transmitted sounds FDA-approved stethoscope