TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06760260

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Human Derived anti-CI135 CAR-T Injection
Description: Autologous genetically modified anti-CI135 CAR transduced T cells
Study: NCT06762171

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: open wedge high tibial osteotomy
Description: All procedures will be performed based on the technique recommended by the AO international knee expert group. Biplanar osteotomy, which comprises osteotomies in the axial and frontal planes, will be performed in all cases. Ascending frontal osteotomy, leaving the tibial tuberosity on the distal fragment, will be also performed. All osteotomies will be performed without the use of additional bone grafts, and the opening of the osteotomy was maintained with a Tomofix plate (Orthomed-E Co., Egypt). Wound closure will be performed in layers.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: open wedge high tibial osteotomy
Description: All procedures will be performed based on the technique recommended by the AO international knee expert group. Biplanar osteotomy, which comprises osteotomies in the axial and frontal planes, will be performed in all cases. Ascending frontal osteotomy, leaving the tibial tuberosity on the distal fragment, will be also performed. All osteotomies will be performed without the use of additional bone grafts, and the opening of the osteotomy was maintained with a Tomofix plate (Orthomed-E Co., Egypt). Wound closure will be performed in layers.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Arthroscopic partial lateral patellar facetectomy
Description: Diagnostic arthroscopy will be performed in all cases to assess Patellofemoral articular cartilage degeneration , assess the lateral compartment and exclude any other pathology. The knee is taken throughout a range of motion to directly visualize the impingement of the lateral patellar facet against the trochlea. Next, a radiofrequency probe is used to outline the area to be resected along the lateral patellar facet While maintaining the knee at 20 degrees of flexion, a 5.5-mm burr is introduced, and under arthroscopic visualization, the overhanging portion of the lateral patellar facet is carefully resected. Once the bony resection is complete, the knee is dynamically re-evaluated (through flexion and extension) for residual impingement and to assess for improvements in patellar mobility. Patellar tracking is assessed to verify that there is no catching in flexion and that patellar mobility is improved.
Study: NCT06760715

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: an interactive m-health self-management
Description: Description: The experimental group will undergo a lifestyle intervention based on the Transtheoretical Model (TTM), utilizing the MOSAC cloud platform. This intervention focuses on self-management to facilitate behavior changes aimed at weight loss and improving Obstructive Sleep Apnea (OSA) of T2DM patients. Key components include self-monitoring, tracking, real-time feedback, and customized weight loss plans, all enhanced by gamification features. The intervention emphasizes a healthy approach to weight loss, promoting a balanced diet, moderate calorie reduction, and increased physical activity, such as step counts. Each stage of the intervention outlines specific objectives, processes, and measures for achieving behavioral change and supporting healthy weight loss.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: In the control group
Description: Description: In the control group, standard medical care will continue to be provided along with written educational pamphlets on weight loss and sleep hygiene. The interactive m-health cloud platform will not be offered. However, the results of the three questionnaires administered to each participant will be individually explained, and any questions will be addressed immediately. After the activity concludes, participants may choose to receive the same intervention as the experimental group, if they wish.
Study: NCT06761365

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LuSeed Aneurysm Embolization System
Description: a permanent intrasaccular implant used for treatment of unruptured intracranial saccular aneurysms (IA) in adult patients according to international guidelines who are indicated for non-emergent endovascular embolization of saccular IAs at the time of presentation.
Study: NCT06761326

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ultrasound guided infraclavicular approach of subclavian vein cannulation
Description: All patients will be in supine position, with the arm abducted to 45 degrees , the angle of the arm will be increased to 90 degrees to best acquire the image.The probe will be placed in he parasgittal plane in the deltopectoral groove medial to the coracoid process . The image will be optimized regarding the depth , focus and the gain accorgingly for the best image of the axillary artery and vein similar to that acquired when performing an infraclavicular approach for brachial plexus block . The probe will be rotated to obtain a longitudinal image of the axillary vein . The needle will be introduced in real time imaging , in an inplane technique and blood will be aspirated , the guidewire will be introduced in real time imaging.The internal jugular vein will be scanned bilaterally via ultrasonography to exclude malposition of the guidewire and will be reported in case of such. The catheter will be introduced through the sheath and will be tunneled the skin.
Study: NCT06090513

Intervention type: COMBINATION_PRODUCT
Intervention: Comprehensive Genomic Profile testing; ELIA software; Molecular Genetic Pathologist consultation
Description: TSO500; detect single nucleotide variants (SNV), INDELs, copy number alterations (CNAs), microsatellite instability (MSI), and tumor mutation burden (TMB) in eligible patients; ELIA software to interface clinic EMR to lab; Consultations and molecular tumor boards by molecular genetic pathologist (MGP)

Intervention type: DIAGNOSTIC_TEST
Intervention: limited genetic testing or no testing
Description: Minimal genetic testing for eligible patients or treatment without testing
Study: NCT05957510

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Serplulimab
Description: serplulimab 300mg, d1, q3w, iv. etoposide 100 mg/m2, d1-3, q3w, iv. carboplatin AUC 5 (up to 750mg), d1, q3w, iv.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Serplulimab
Description: serplulimab 300mg, d1, q3w, iv. etoposide 100 mg/m2, d1-3, q3w, iv. carboplatin AUC 5 (up to 750mg), d1, q3w, iv.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SOC
Description: the treatment recommended by the investigator
Study: NCT06270524

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Blood sampling
Description: Blood sampling will be taken for further analysis

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Blood sampling
Description: Blood sampling will be taken for further analysis

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Blood sampling
Description: Blood sampling will be taken for further analysis
Study: NCT05368857

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Afamelanotide
Description: Up to 10 adult healthy volunteers will be enrolled in this study in which small areas of their skin will be exposed to UVR and skin samples taken. UV-induced DNA damage and repair will be analysed.
Study: NCT06761326

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Ultrasound guided infraclavicular approach of subclavian vein cannulation
Description: All patients will be in supine position, with the arm abducted to 45 degrees , the angle of the arm will be increased to 90 degrees to best acquire the image.The probe will be placed in he parasgittal plane in the deltopectoral groove medial to the coracoid process . The image will be optimized regarding the depth , focus and the gain accorgingly for the best image of the axillary artery and vein similar to that acquired when performing an infraclavicular approach for brachial plexus block . The probe will be rotated to obtain a longitudinal image of the axillary vein . The needle will be introduced in real time imaging , in an inplane technique and blood will be aspirated , the guidewire will be introduced in real time imaging.The internal jugular vein will be scanned bilaterally via ultrasonography to exclude malposition of the guidewire and will be reported in case of such. The catheter will be introduced through the sheath and will be tunneled the skin.
Study: NCT06761963

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Whole-body electrical stimulation
Description: Performed using Miha Bodytec equipment, properly calibrated, with electrodes on the quadriceps, hamstrings, glutes, biceps, triceps, pectorals, abdomen, trapezius, latissimus dorsi and quadratus lumborum muscles.

Intervention type: OTHER
Group type: OTHER
Intervention: Rehabilitation
Description: Pulmonary rehabilitation program.
Study: NCT06760962

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Reflective Mindfulness and Emotional Regulation training
Description: The RMERT program consisted of six weekly 90-minute sessions facilitated by researchers trained in cognitive behavioral therapy (CBT) and transactional analysis (TA). The training employed the ABC model of CBT (Activating events, Beliefs, and Consequences) to address maladaptive cognitive patterns, along with TA techniques such as empathic inquiry and reflection. Relaxation strategies, including diaphragmatic breathing and progressive muscle relaxation, were also integrated. The sessions focused on enabling students to reflect on their mental and emotional states, process their feelings, and apply cognitive reappraisal-a healthy emotional regulation strategy-instead of relying on expressive suppression, which is maladaptive.
Study: NCT06761248

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Fluorescent Starch Nanoparticles Caries Detection Rinse
Description: The fluorescent starch nanoparticles caries detection rinse is an innovative diagnostic tool designed to enhance the early detection of active dental caries. It contains proprietary fluorescent starch nanoparticles that infiltrate the porous enamel of active caries lesions. Upon illumination with a standard dental curing light, the nanoparticles fluoresce, allowing clinicians to differentiate active caries from inactive lesions and other enamel conditions. This rinse is evaluated as a non-invasive, highly sensitive, and specific diagnostic device.
Study: NCT06762093

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: surgical repaire
Description: * Primary closure of lacerations~* Eyelid margin repair~* Eyelid crease reconstruction~* Eyelid transposition flaps or grafts~* Tarsorrhaphy
Study: NCT06760871

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: nebulised distilled water
Description: After the surgery, the patients will be admitted to the ward and taken to the bed, and their care and treatment will be applied by the nurse. Afterwards, the researcher will apply cold vapour as an inhaler for 15 minutes. For this application, the stand to which the ultrasonic nebuliser device is connected will be positioned close to the patient's bed. 200 ml of distilled water will be placed in the liquid reservoir of the device. The patient will be given a comfortable position and the device will be adjusted so that the steam hose covers the patient's mouth and nose and the patient will be allowed to inhale the steam through the mouth and nose. After the electrical connection of the device is provided, the device will be started and cold steam application will begin. In the 1st hour, inhaler cold water vapour application will be performed for 15 minutes.
Study: NCT06762665

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Spinal injection
Description: Patients underwent a spinal injection procedure under CT scan

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Spinal injection
Description: Patients underwent a spinal injection procedure under CT scan

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Spinal injection
Description: Patients underwent a spinal injection procedure under CT scan

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: pre-operative consultation
Description: Pre-operative consultation, in person or by teleconsultation, consists of an interview about the patient's history and symptoms. This is followed by a clinical examination and consultation of the patient's imaging file, to confirm the request for paraspinal infiltration and its location. In addition, the radiologist explains the procedure to the patient, supplementing the explanatory documents already provided at the time of the appointment, and outlines the results that may be expected and any complications.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: pre-operative consultation
Description: Pre-operative consultation, in person or by teleconsultation, consists of an interview about the patient's history and symptoms. This is followed by a clinical examination and consultation of the patient's imaging file, to confirm the request for paraspinal infiltration and its location. In addition, the radiologist explains the procedure to the patient, supplementing the explanatory documents already provided at the time of the appointment, and outlines the results that may be expected and any complications.
Study: NCT06762236

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Pillatate Training
Description: .The session will repeated three times per week for 6 weeks with 40-minute sessions In Pilates we include 5 Pilate exercise, The Hundred (Rhythmic Breathing), Single Leg Stretch (Rhythmic Breathing), side kick, Toe Taps (Set Breathing Pattern) ,leg pull front for 6 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pillatate Training
Description: .The session will repeated three times per week for 6 weeks with 40-minute sessions In Pilates we include 5 Pilate exercise, The Hundred (Rhythmic Breathing), Single Leg Stretch (Rhythmic Breathing), side kick, Toe Taps (Set Breathing Pattern) ,leg pull front for 6 weeks.
Study: NCT06761859

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aromatherapy Inhalation in Psychiatric Nurses
Description: Aromatherapy inhalation using 2% diluted lavender essential oil will be applied to 33 psychiatric nurses in the experimental group, 30 minutes before starting work, every other day during a week. The lavender essential oil to be used in the study will be dropped 3 drops onto a cotton handkerchief cut into a disc shape and fixed to the clothes of the psychiatric nurses, 20 cm away from their noses, and they will be asked to inhale it for 30 minutes.
Study: NCT06760689

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: virtual reality glasses
Description: One of the videos chosen by the patient will be opened in the virtual reality glasses and will be played for 20 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: scale
Description: The patient received standard nursing care. Scales were filled in after the course.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: scale
Description: The patient received standard nursing care. Scales were filled in after the course.
Study: NCT06760780

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental
Description: The experimental group will first be given a theoretical lesson prepared in line with the current literature on osteoporosis. At the end of the lesson, a prepared scenario example on osteoporosis will be covered.

Intervention type: OTHER
Group type: OTHER
Intervention: Control
Description: The control group will only be given a theoretical lesson prepared in line with the current literature on osteoporosis. No other intervention will be made.
Study: NCT06762119

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CAR-T cell
Description: CAR-T cell
Study: NCT05950516

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Up to 1.0 mg semaglutide injected subcutaneously once-weekly for 32 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Semaglutide Pen Injector [Ozempic]
Description: Up to 1.0 mg semaglutide injected subcutaneously once-weekly for 32 weeks
Study: NCT05379712

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Resource® Support Plus
Description: Nestlé Resource Support Plus® is a high energy- and protein-density Medical Food enriched with omega 3 polyunsaturated fatty acids. This is a nutritionally complete formula, in an easy to swallow, palatable, concentrated low volume, available in 2 flavours optimized for cancer patients undergoing chemotherapy and/or radiation in taste tests. It provides in a 125 mL serving: 250 kcal, 11.5 g protein and 0.95g of omega-3 fatty acid (eicosapentaenoic acid, EPA).
Study: NCT06438445

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Real Jelly
Description: Participants will receive 500mg of royal jelly capsules per day for two months.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants will receive 500mg of placebo capsules per day for two months.
Study: NCT04675684

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Recovery-group
Description: The complex intervention are instructions in ruminations-therapy and mindfulness, advice in healthy diets, physical - and social activities and sleep hygiene, and support in smoking cessation, alcohol counseling and medication adherence.
Study: NCT04726033

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 64Cu-DOTA-TLX592
Description: TLX592, a humanised, engineered monoclonal antibody HuX592r conjugated with a DOTA chelator and radiolabelled with 64Cu (64Cu-TLX592)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 64Cu-DOTA-TLX592
Description: TLX592, a humanised, engineered monoclonal antibody HuX592r conjugated with a DOTA chelator and radiolabelled with 64Cu (64Cu-TLX592)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 64Cu-DOTA-TLX592
Description: TLX592, a humanised, engineered monoclonal antibody HuX592r conjugated with a DOTA chelator and radiolabelled with 64Cu (64Cu-TLX592)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 64Cu-DOTA-TLX592
Description: TLX592, a humanised, engineered monoclonal antibody HuX592r conjugated with a DOTA chelator and radiolabelled with 64Cu (64Cu-TLX592)
Study: NCT04860934

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dual Task Training Program Group
Description: Fifteen patients will receive Dual Task Training Program. Total Period: 8 Weeks.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control Group
Description: Each child in this group will receive the selected physical therapy program which include mobility exercises, strengthening exercises, balance exercises, gait training exercises, and exercises to improve physical conditioning for one-hour session three times weekly for 8 successive weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Control Group
Description: Each child in this group will receive the selected physical therapy program which include mobility exercises, strengthening exercises, balance exercises, gait training exercises, and exercises to improve physical conditioning for one-hour session three times weekly for 8 successive weeks.
Study: NCT04971538

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: OraQuick® HCV Self-Test
Description: The OraQuick® HCV Self-Test is a lateral flow rapid diagnostic that can detect anti-HCV antibodies in oral fluid. Instructions for Use (IFU) for OraQuick® HCV Rapid Antibody Self-Test have been developed in Georgian for the previous 2 studies conducted in Georgia using the OraQuick® HCV Rapid Antibody Self-Test. The IFU has been optimized taking in the feedback on the IFU resulting from the aforementioned studies. As this HCV test is not approved for self-test use in Georgia, all tests will be labelled as Research Use Only (RUO) and test results will not be used for patient management.
Study: NCT03641248

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Enteric coated Devil's Claw
Description: Enteric coated capsules containing Devil's Claw extract with 100mg harpagoside

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Non-enteric coated Devil's Claw
Description: Non-enteric coated capsules containing Devil's Claw extract with 100mg harpagoside
Study: NCT05304117

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Advance Care Planning
Description: Community Information Session and Private Sharing Session with trained social worker

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Advance Care Planning
Description: Community Information Session and Private Sharing Session with trained social worker
Study: NCT06065059

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TNG348
Description: Ubiquitin Specific Peptidase 1 (USP1) inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olaparib
Description: PARP inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olaparib
Description: PARP inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olaparib
Description: PARP inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olaparib
Description: PARP inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olaparib
Description: PARP inhibitor
Study: NCT05712356

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: FOLFOX regimen
Description: The following will be given every 14 days:~* oxaliplatin 85 mg/m² and l-folinic acid 200 mg/m² or d,l-folinic acid 400 mg/m² concurrently, as a 2-hour IV infusion~* fluorouracil (5-FU) 400 mg/m² will be given as an IV bolus over 5 minutes~* fluorouracil (5-FU) 2400 mg/m² will be administered over 46 hours (via home-infusion pump)

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo given as a slow IV push over 1 minute when standard treatment(s) are given

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo given as a slow IV push over 1 minute when standard treatment(s) are given