TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06499168

Intervention type: DRUG
Intervention: neoadjuvant chemotherapy: anthracycline based chemotherapy and taxans before surgery
Description: In locally advanced breast cancer patients who will receive neoadjuvant chemotherapy formalin fixed paraffin embedded tissue specimen of the baseline TCNB of locally advanced breast cancer will be obtained from pathology laboratory, Pathology Department, Assiut University.~* Histological diagnosis of H\&E stained sections will be confirmed.~* Immunohistochemical staining for CD10 .~* Baseline clinicopathological features of patients who will receive neoadjuvant chemotherapy will be collected from patients' records.~* Correlation between CD10 expression and the baseline clinicopathological features with the response to neoadjuvant chemotherapy.
Study: NCT05010512

Intervention type: DEVICE
Group type: OTHER
Intervention: Delefilcon A contact lenses
Description: Commercially available silicone hydrogel contact lenses used as indicated

Intervention type: DEVICE
Group type: OTHER
Intervention: Delefilcon A contact lenses
Description: Commercially available silicone hydrogel contact lenses used as indicated

Intervention type: DEVICE
Group type: OTHER
Intervention: Kalifilcon A contact lenses
Description: Commercially available silicone hydrogel contact lenses used as indicated

Intervention type: DEVICE
Group type: OTHER
Intervention: Kalifilcon A contact lenses
Description: Commercially available silicone hydrogel contact lenses used as indicated
Study: NCT06483815

Intervention type: DIAGNOSTIC_TEST
Intervention: Culture, İsolation
Description: Data on patient demographics, clinical conditions, and fungal infection positivity rates were extracted from hospital records. Fungal positivity rates were calculated based on laboratory results and presented as percentages. Statistical analyses were performed using the Chi-Square test, and p-values were reported.
Study: NCT04958681

Intervention type: OTHER
Intervention: exercise
Description: The participants were subsequently asked whether the pandemic had altered their physical activity status and rate the severity of reduction in mobility level compared to the period before the Covid-19 with the following options: none, 0; mild, 1; moderate, 2; severe, 3. Then, the participants were also asked whether they perform a physical exercise in a home setting. We recorded regular outdoor physical activity and home-based exercises (only after the pandemic) as a dichotomous variable (yes or no). The number of physical activity days per week was also obtained.

Intervention type: OTHER
Intervention: exercise
Description: The participants were subsequently asked whether the pandemic had altered their physical activity status and rate the severity of reduction in mobility level compared to the period before the Covid-19 with the following options: none, 0; mild, 1; moderate, 2; severe, 3. Then, the participants were also asked whether they perform a physical exercise in a home setting. We recorded regular outdoor physical activity and home-based exercises (only after the pandemic) as a dichotomous variable (yes or no). The number of physical activity days per week was also obtained.
Study: NCT02389569

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Adhesive system
Description: Etch-and-rinse and Self-etch adhesive system will be applied in volunteers that received different types of restoration protocol.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Restoration protocol
Description: Volunteers will be treated by two types of protocol restoration : 1) Biosilicate (powder) or 2) Control (without Biosilicate). In sequence, adhesive (self-etch or etch and rinse) and composite resin will be used for restoration.
Study: NCT05492812

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chloral Hydrate
Description: Chloral Hydrate

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydroxyzine
Description: Hydroxyzine

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Melatonin
Description: Melatonin
Study: NCT05435222

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Male-specific psychotherapeutic program (MSPP)
Description: The MSPP for MDD is designed to be used for the acute treatment of depression in men in 18 sessions over a period of 18 weeks. Therapy is delivered weekly with homework bridging every session. Central CBT elements (e.g. behavioral activation, cognitive restructuring) will be retained in MSPP. During implementation of typical CBT techniques, masculine role norms will be considered. One underlying topic will be the potential of multiple masculinities to coexist, being fluid and relational within one man, emphasizing positive aspects of masculinities compatible with psychotherapy for MDD.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Male-specific psychotherapeutic program (MSPP)
Description: The MSPP for MDD is designed to be used for the acute treatment of depression in men in 18 sessions over a period of 18 weeks. Therapy is delivered weekly with homework bridging every session. Central CBT elements (e.g. behavioral activation, cognitive restructuring) will be retained in MSPP. During implementation of typical CBT techniques, masculine role norms will be considered. One underlying topic will be the potential of multiple masculinities to coexist, being fluid and relational within one man, emphasizing positive aspects of masculinities compatible with psychotherapy for MDD.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive beahvioral therapy (CBT)
Description: This intervention consists of 18 sessions of manualized, standard cognitive behavioral therapy for major depression. Therapy is delivered weekly with homework bridging every session.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive beahvioral therapy (CBT)
Description: This intervention consists of 18 sessions of manualized, standard cognitive behavioral therapy for major depression. Therapy is delivered weekly with homework bridging every session.
Study: NCT03953170

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Teduglutide
Description: Teduglutide (Gattex, Shire) was approved by the FDA in 2012 for use in adult patients with short bowel syndrome requiring parenteral support only.~The results of this study will not be used to justify a change of indication, or dose currently approved for Teduglutide, and will not be used to advertise the drug. This study meets all of the requirements for exemption from the IND regulations and an IND exemption has been confirmed by the FDA.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT05112328

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Exocrine Pancreatic Enzyme
Description: Pancreatic enzyme supplementation for critically ill patients on enteral nutrition

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo of Pancreatic enzyme for critically ill patients on enteral nutrition
Study: NCT04049331

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Testosterone Undecanoate 750 MG/3 ML Intramuscular Solution [AVEED]
Description: first two doses four weeks apart; following three more doses every ten weeks.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: first two doses four weeks apart; following three more doses every ten weeks.
Study: NCT04774081

Intervention type: DEVICE
Intervention: 24h Continuous glucose monitoring and urinary C-peptide collection
Description: Participants will be admitted to the research clinic for a 24-hour stay in a metabolic chamber. During the chamber stay, all urine excreted will be collected to assess C-peptide urinary excretion rate and interstitial glucose will be measured by a continuous glucose monitor (CGM). Participants will consume a eucaloric diet (50% carbohydrates, 30% fat and 20% protein).
Study: NCT06259695

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Adjustable Aquatic Therapy Prosthesis
Description: We will recruit up to three participants, who will attend up to two fitting appointments lasting up to one hour to assist in the design development. After the design of the prosthesis is completed, participants will attend three, 30-minute, aquatic therapy sessions with a physical therapist trained in aquatic therapy and utilize the prosthesis.
Study: NCT06428448

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: REMEDY Spectrum IM Spacer Nail
Description: The REMEDY SPECTRUM IM Spacer Nail is a single-use implant made of polymethylmethacrylate (PMMA) which is internally reinforced with a stainless-steel core (ASTM F138, ISO 5832-1). The PMMA of the REMEDY SPECTRUM IM Spacer Nail is laden with gentamicin and vancomycin.~The nail has a slot at the distal end and can be combined with the surgeon's choice of fixation to prevent migration depending on the anatomy of the patient. The REMEDY SPECTRUM IM Spacer Nail is available in two lengths (150mm and 300mm) to accommodate variations in patient anatomy. The distal end has a threaded recess for mating with the optional distal cap, as well as the insertion and removal tools.
Study: NCT04553263

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Contrave 8Mg-90Mg Extended-Release Tablet
Description: Naltrexone HCl/Bupropion HCl is an FDA-approved weight-loss medication with efficacy via the mesolimbic dopamine system to reduce hunger and help control cravings.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupropion
Description: Bupropion is FDA-approved and marketed both as an antidepressant agent (Wellbutrin®) and treatment for smoking cessation (Zyban®) and has shown efficacy in reducing symptoms of depression and drug craving in stimulant users. it is also a promising candidate to improve cognition function.
Study: NCT05790564

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Almond
Description: Daily consumption of 2 ounces of unsalted, dry roasted almonds for 12 weeks

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Crackers
Description: Daily consumption of non-whole grain crackers for 12 weeks (caloric equivalent to 2 ounces of dry roasted almonds)
Study: NCT05151042

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: wafer-less approach
Description: Using the software, 3D digitized bony mandible will be virtually osteotomized and repositioned to the new postoperative position. CAD/CAM generated preoperative wafer will be placed on the lower arch dentition, the guide has an extension to guide medial, vertical, oblique cuts as well as screw holes for reference landmarks for proximal segment \& tooth bearing segment. Drilling of all the reference landmarks on the proximal segment and locating medial, vertical, oblique cuts.~Removal of guide, then BSSO is performed. The final wafer is placed, the guiding hole on the proximal segment will then be realigned with the previously drilled screw holes, fixation using mono cortical screws then drilling screw holes for plate fixation.~Fixation of the osteotomy using 2.0 mm pre-bent mini plates.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Computer Guided orthognathic surgery using occlusal wafers
Description: Using the software, 3D digitized bony mandible will be virtually osteotomized and repositioned to the new postoperative position.~dental casts will be scanned dental casts are superimposed to the CT cuts into the virtual software environment to produce final wafer CAD/CAM repositioning guide. the generated preoperative wafer will be placed on the lower arch dentition, the guide has an extension to guide medial, vertical, oblique cuts as well as screw holes for reference landmarks for proximal segment \& tooth bearing segment.~Drilling of all the reference landmarks on the proximal segment and locating medial, vertical, oblique cuts. Removal of guide, then BSSO is performed.~The final wafer is placed, the guiding hole on the proximal segment will then be realigned with the previously drilled screw holes, fixation using mono cortical screws then drilling screw holes for plate fixation.~Fixation of the osteotomy using 2.0 mm pre-bent mini plates.
Study: NCT05064111

Intervention type: DIAGNOSTIC_TEST
Intervention: TRUS biopsy
Description: The biopsy procedure will be completed using an FDA-approved ultrasound machine with the addition of an investigational (non-FDA approved) image fusion software.
Study: NCT06619457

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mitopure (Urolithin A) Cream
Description: cosmetic cream to be applied topically on face and forearms twice/daily using split/face design

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo Cream
Description: cosmetic cream to be applied topically on face and forearms twice/daily using split/face design
Study: NCT06625697

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness Meditation
Description: Participants will be instructed on how to wear the physiological monitoring equipment during the 14-unit mindfulness meditation curriculum. Participants will then complete 2-10 minute guided seated Equa training lessons on a laboratory smartphone device while physiological measures are tracked. After training lessons, a respiration biosignal feedback chart will appear on the smartphone screen. Participants will also complete a brief mindfulness survey before and after training lessons.
Study: NCT06625853

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mtwo R files with Xp-Endo finisher file
Description: XP-endo Finisher file will be inserted without rotation into the root canals filled with 2.5% NaOCl and will be activated (800 rpm; torque of 1 N.cm) for~1 min in each canal using slow and gentle 7-8 mm lengthwise movements.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mtwo R files
Description: obturation material will be removed using Mtwo R (VDW, Munich, Germany)files attached to an endodontic motor (Ecube, seachin, Korea) with a constant speed of 280 rpm, as suggested by the manufacturer. Mtwo R 25/0.05 will be used to empty the coronal and middle thirds of the root. Mtwo R 15/0.05 will be used to reach the working length.
Study: NCT06624410

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Educational Intervention
Description: Pre-operative anxiety levels will be assessed with the mYPAS-SF6-12 (below). Subjects will be observed for behaviors and then given a score out of possible 5 across 5 domains that corresponds with demonstrated behaviors, specified in the figure below. The 5 domains include Activity, Vocalization, Emotional Expressivity, State of Arousal, and Use of Parent. Note that the Vocalization domain differs in that It's possible scores range from 1-7. Pilot data collection will involve mYPAS scoring in isolation to demonstrate existing anxiety burden at Doernbecher Children's Hospital.
Study: NCT05890625

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: On going treatment
Description: No additional attempts will be made by the investigator on the cases in the control group. These cases will only benefit from the services in the clinic.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: InT-mAp
Description: InT-mAp, the content of which will be created as a result of the evaluation of the nursing needs of infertile women, consists of a web-based training and online consultancy platform. The treatment plan specific to each participant will be entered into the web base individually, and the participants will be able to follow and manage the treatment protocols and appointments under their own control. InT-mAp is a guide that helps breakers about the intended use, effects, side effects of the drugs under treatment and how to self-administer, especially for women.
Study: NCT05197257

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ga-PSMA-11
Description: The PSMA Sterile Cold Kit, is a kit comprising all needed materials (lyophilized PSMA for PSMA reconstitution, elution vial for Ga and ancillary materials for transfer between vials) to perform a room-temperature radiolabelling of PSMA-11 with Ga. Ga is not part of the kit and should be provided in the form gallium chloride solution following the requirements of the relevant local regulations. PSMA-11 radiolabelled with Ga is administered in patients with prostate cancer recurrence after radical treatment.
Study: NCT05713812

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Kinesiotaping
Description: Kinesiotape will be applied

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Control Treatment
Description: IFC + Hot pack for 20 minutes MDT (prone positioning) for 10 minutes. Lumbar SNAGs + lumbar rotation mobilization. Home exercise plan: MDT for 10 min + patient education to avoid flexion based activities.
Study: NCT06020664

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NOX-1416+SOC
Description: NOX1416+SOC as provided in Arm/group description

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo+SOC
Description: Placebo+SOC as provided in Arm/group description
Study: NCT05149781

Intervention type: PROCEDURE
Intervention: Standardized diagnosis and treatment
Description: Patients with endocrine hypertension undergo surgery or medication depending on the cause after completion of standard diagnostic procedures. Patients with primary hypertension receive medication.
Study: NCT06385002

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Remimazolam
Description: After tracheal intubation, the experimental group will maintain oxygen-air (O2-Air) at 2 liters/minute, and remimazolam will be infused at 1.0mg/kg/h, while adjusting the concentration of sevoflurane to maintain the depth of anesthesia with a bispectral index (BIS) of 40-60.
Study: NCT05246072

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ivermectin + colchicine
Description: In addition to the local standard of care for COVID 19 patients, the patient will receive Ivermectin + colchicine

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Colchicine
Description: In addition to the local standard of care for COVID 19 patients, the patient will receive colchicine
Study: NCT05461014

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: dCBI
Description: The dCBI, RxWell, is a trans-CBT mobile app product addressing depression and anxiety that was developed based on standard CBT techniques. RxWell provides users users with 40 brief (5-10 minute) skill building techniques for anxiety and depression. Users will have access to a goal-setting tab and in the moment relief section which contains over 17 techniques,14 of which are brief audios to help users engage relaxation responses. The user will be provided with the depression path, which has 40 unique techniques, and if the user expresses significant anxiety, the coach will have the ability to personalize the program by pulling in any of the 53 techniques from the anxiety path, so that the individual can utilize the proper CBT techniques that fit with their presentation. The coaches are trained to provide assistance with adult care transition readiness.
Study: NCT06001281

Intervention type: OTHER
Group type: OTHER
Intervention: plasma collection
Description: Plasma samples will be prospectively collected at relevant time points during patient treatment.
Study: NCT04676126

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Lumega-Z
Description: Medical food which contains lutein, zeaxanthin, and meso-zeaxanthin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dorzolamide Hcl 2% Oph Soln
Description: Topical carbonic anhydrase inhibitor

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Specially formulated non macular pigment-containing formulation which tastes similar to the commercial medical food being evaluated in this study
Study: NCT05464576

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: MRI
Description: Using the MRI in the diagnosis of the bladder cancer (invasive or not)
Study: NCT06142942

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise Intervention
Description: Participants will complete an exercise intervention where they will exercise 2, 3, or 4 days per week for 4 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise Intervention
Description: Participants will complete an exercise intervention where they will exercise 2, 3, or 4 days per week for 4 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise Intervention
Description: Participants will complete an exercise intervention where they will exercise 2, 3, or 4 days per week for 4 weeks.
Study: NCT04804267

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Linaclotide
Description: Manufactured by Jiangsu Hansoh Pharmaceutical Co., Ltd. Drug: Linaclotide 145μg orally once daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: LINZESS®
Description: Manufactured by Almac Pharma Services Limited Drug: Linaclotide 145μg orally once daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Drug: Placebo orally once daily
Study: NCT06417177

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will receive a placebo in pill form.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will receive a placebo in pill form.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will receive a placebo in pill form.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propranolol
Description: Participants will receive oral propranolol (1 mg/kg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propranolol
Description: Participants will receive oral propranolol (1 mg/kg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propranolol
Description: Participants will receive oral propranolol (1 mg/kg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemtesa
Description: Participants will receive oral gemtesa (75 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemtesa
Description: Participants will receive oral gemtesa (75 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemtesa
Description: Participants will receive oral gemtesa (75 mg).
Study: NCT05415605

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Lung Strain
Description: The main objective of this study is to describe the physiological values of lung strain in healthy volunteers as well as its variations induced by non-invasive positive pressure ventilation and their correlation with tidal volume.