TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04969003

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Short videos
Description: Intervention videos will each be of 90-second duration and feature four underage professionals (ages 16) acting as simulated patients. All videos will focus on an empowered presenter with depression sharing their personal story regarding depression and describe how social supports from family, friends, and community, as well as professional help assisted them in overcoming symptoms of their illness. The actors will include a transgender male, a cis-gender male, a transgender female, and a cis-gender female.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Short videos
Description: Intervention videos will each be of 90-second duration and feature four underage professionals (ages 16) acting as simulated patients. All videos will focus on an empowered presenter with depression sharing their personal story regarding depression and describe how social supports from family, friends, and community, as well as professional help assisted them in overcoming symptoms of their illness. The actors will include a transgender male, a cis-gender male, a transgender female, and a cis-gender female.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Short videos
Description: Intervention videos will each be of 90-second duration and feature four underage professionals (ages 16) acting as simulated patients. All videos will focus on an empowered presenter with depression sharing their personal story regarding depression and describe how social supports from family, friends, and community, as well as professional help assisted them in overcoming symptoms of their illness. The actors will include a transgender male, a cis-gender male, a transgender female, and a cis-gender female.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Short videos
Description: Intervention videos will each be of 90-second duration and feature four underage professionals (ages 16) acting as simulated patients. All videos will focus on an empowered presenter with depression sharing their personal story regarding depression and describe how social supports from family, friends, and community, as well as professional help assisted them in overcoming symptoms of their illness. The actors will include a transgender male, a cis-gender male, a transgender female, and a cis-gender female.
Study: NCT06423729

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nicorandil 10 MG
Description: Patients will receive oral Nicorandil 10 MG twice daily in addition to 2nd generation sulfonylureas , for 3 months.
Study: NCT06093529

Intervention type: DIAGNOSTIC_TEST
Intervention: complete blood count, CD3+ , CD4+ , CD8+, CD16+, CD56+, IFN-γ.
Description: 1. Full history~2. Thorough clinical examinations~3. Laboratory investigations will include:~   1. complete blood count with focus on platelet count, platelet distribution width and mean platelet volume. Platelet count will be confirmed by direct blood film and blood smear.~  2. Measurements of CD3+, CD4+, CD8+ and natural killer cells (CD16+, CD56+) will be conducted using flow cytometry.~  3. Serum IFN-γ levels will be determined using an ELISA kit.~4. Response to the treatment will be assessed according to The International Working Group criteria which defines Response as platelet count ≥ 30 x 10⁹/L and \>2-fold increase in platelet count from baseline and absence of bleeding, measured on 2 occasions greater than 7 days apart. No response is characterized by a platelet count \<30 x 10⁹/L or a less than 2-fold increase in platelet count from baseline, or the presence of bleeding.

Intervention type: DIAGNOSTIC_TEST
Intervention: complete blood count, CD3+ , CD4+ , CD8+, CD16+, CD56+, IFN-γ.
Description: 1. Full history~2. Thorough clinical examinations~3. Laboratory investigations will include:~   1. complete blood count with focus on platelet count, platelet distribution width and mean platelet volume. Platelet count will be confirmed by direct blood film and blood smear.~  2. Measurements of CD3+, CD4+, CD8+ and natural killer cells (CD16+, CD56+) will be conducted using flow cytometry.~  3. Serum IFN-γ levels will be determined using an ELISA kit.~4. Response to the treatment will be assessed according to The International Working Group criteria which defines Response as platelet count ≥ 30 x 10⁹/L and \>2-fold increase in platelet count from baseline and absence of bleeding, measured on 2 occasions greater than 7 days apart. No response is characterized by a platelet count \<30 x 10⁹/L or a less than 2-fold increase in platelet count from baseline, or the presence of bleeding.
Study: NCT05635643

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CHS-114
Description: CHS-114
Study: NCT06263829

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Use of Tappt App
Description: Use of Tappt, a novel digital medication companion solution
Study: NCT05635643

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CHS-114
Description: CHS-114

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CHS-114
Description: CHS-114

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: toripaliamab
Description: toripalimab-tpzi
Study: NCT05879211

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Feedback
Description: Providers will receive detailed feedback about the timing, quality, and frequency of their goals of care communication with patients
Study: NCT06659887

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: nasal cannula
Description: After induction, bag-mask ventilation with 100% oxygen and flow rates of 6 L/ min will be carried out until the expired oxygen concentration will be \>90%, saturation of oxygen was 100%, and end tidal carbon dioxide was 30-40 mmHg. Once this will be reached, bag-mask ventilation will be stopped and apneic oxygenation will be initiated for 3 minutes

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: nasal cannula
Description: After induction, bag-mask ventilation with 100% oxygen and flow rates of 6 L/ min will be carried out until the expired oxygen concentration will be \>90%, saturation of oxygen was 100%, and end tidal carbon dioxide was 30-40 mmHg. Once this will be reached, bag-mask ventilation will be stopped and apneic oxygenation will be initiated for 3 minutes

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: nasal cannula
Description: After induction, bag-mask ventilation with 100% oxygen and flow rates of 6 L/ min will be carried out until the expired oxygen concentration will be \>90%, saturation of oxygen was 100%, and end tidal carbon dioxide was 30-40 mmHg. Once this will be reached, bag-mask ventilation will be stopped and apneic oxygenation will be initiated for 3 minutes
Study: NCT06611137

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: SBRT+Toripalimab Plus Docetaxel and Cisplatin
Description: All participants will receive SBRT (18Gy/3 fractions, QOD ) to gross tumor and metastatic lymph nodes, followed by neoadjuvant chemoimmunotherapy of Toripalimab (240mg) Plus Docetaxel (75mg/m2, q3w) and Cisplatin (75mg/m2, q3w) for 3 cycles. If tumor has complete or partial response at 2 weeks after the last course of neoadjuvant chemotherapy, participants will then receive intensity modulated radiotherapy (54Gy/27 fractions). If tumor is stable or progressive, participants will receive radical resection with or without postoperative intensity modulated radiotherapy when necessary.
Study: NCT06611514

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prasterone (DHEA)
Description: Prasterone 6.5 mg vaginal tablets
Study: NCT05398341

Intervention type: DEVICE
Intervention: The BEAR® Implant
Description: The BEAR Implant is a bovine collagen-based implant. The bovine tissue is sourced from countries that are free of bovine spongiform encephalopathy \[BSE\] and is further treated to remove bovine cell fragments and DNA.~The BEAR® (Bridge Enhanced ACL Restoration) Implant is a bovine extracellular matrix collagen-based implant for treatment of anterior cruciate ligament (ACL) injuries. The BEAR® Implant is indicated for skeletally mature subjects at least 14 years of age with a complete rupture of the ACL. Subjects must have an ACL stump attached to the tibia to construct the repair.

Intervention type: DEVICE
Intervention: The BEAR® Implant
Description: The BEAR Implant is a bovine collagen-based implant. The bovine tissue is sourced from countries that are free of bovine spongiform encephalopathy \[BSE\] and is further treated to remove bovine cell fragments and DNA.~The BEAR® (Bridge Enhanced ACL Restoration) Implant is a bovine extracellular matrix collagen-based implant for treatment of anterior cruciate ligament (ACL) injuries. The BEAR® Implant is indicated for skeletally mature subjects at least 14 years of age with a complete rupture of the ACL. Subjects must have an ACL stump attached to the tibia to construct the repair.
Study: NCT06608888

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: Multimodal MRI technology is a method that combines various magnetic resonance imaging techniques, providing more comprehensive images and information about human tissues and organs. These different imaging techniques include, but are not limited to:~Structural MRI (sMRI): Provides information about the types of brain tissues, such as gray matter, white matter, and cerebrospinal fluid.~Functional MRI (fMRI): Dynamically measures the hemodynamic response related to brain neural activity, commonly used to study brain functional activities.~Diffusion Tensor Imaging (DTI): Offers information on the structural connections between brain regions, which can be used to study the neural fiber pathways of the brain

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: Multimodal MRI technology is a method that combines various magnetic resonance imaging techniques, providing more comprehensive images and information about human tissues and organs. These different imaging techniques include, but are not limited to:~Structural MRI (sMRI): Provides information about the types of brain tissues, such as gray matter, white matter, and cerebrospinal fluid.~Functional MRI (fMRI): Dynamically measures the hemodynamic response related to brain neural activity, commonly used to study brain functional activities.~Diffusion Tensor Imaging (DTI): Offers information on the structural connections between brain regions, which can be used to study the neural fiber pathways of the brain
Study: NCT06614322

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pregabalin
Description: 300mg/day pregabalin capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pregabalin
Description: 300mg/day pregabalin capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pregabalin
Description: 300mg/day pregabalin capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Duloxetine
Description: 60mg/day duloxetine capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Duloxetine
Description: 60mg/day duloxetine capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Duloxetine
Description: 60mg/day duloxetine capsule

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo capsule

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo capsule

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo capsule
Study: NCT06613503

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: AI-supporter
Description: rticipants in the experimental group will use the AI-supporter, an intelligent excretion management robot. This device utilizes AI-driven visual recognition technology to automatically detect urine and feces, followed by a cleaning and drying process. When the AI-supporter detects excretion, it activates an automated sequence that washes, dries, and sanitizes the perineal area without requiring the caregiver to remove the diaper. The AI-supporter also records relevant data, such as the time, frequency, and weight of excretion, for further analysis. This intervention is designed to reduce the incidence of urinary tract infections (UTIs) and incontinence-associated dermatitis (IAD), as well as lessen the workload for caregivers
Study: NCT05504343

Intervention type: DEVICE
Group type: OTHER
Intervention: Intensity SL Intraocular Lens
Description: Cataract surgery and intraocular lens implantation
Study: NCT06615037

Intervention type: OTHER
Intervention: Assess Hip joint strength by Biodex isokinetic dynamometer (System 4 Pro)
Description: Assessment of the strength of hip flexors and extensors muscles:~* Participants will be in a supine-lying position, the highest reliability (ICC = 0.90) according to the results of the meta-analysis (Contreras et al., 2021).~* Seat orientation 0°.~* Dynamometer tilt 0° and orientation 0°.~* The axis of the dynamometer on the greater trochanter of the femur.~* The test parameters included a 0-90 degree range of motion.~* During the isokinetic testing movement, the hip was first flexed from a neutral (starting) position to 90° (for hip flexion) and then the direction of the movement was reversed (for hip extension)~* Angular speed at 120°/s which shows excellent reliability (ICC = 95%) with concentric contraction mode (Contreras et al., 2021) .

Intervention type: OTHER
Intervention: Assess Hip joint strength by Biodex isokinetic dynamometer (System 4 Pro)
Description: Assessment of the strength of hip flexors and extensors muscles:~* Participants will be in a supine-lying position, the highest reliability (ICC = 0.90) according to the results of the meta-analysis (Contreras et al., 2021).~* Seat orientation 0°.~* Dynamometer tilt 0° and orientation 0°.~* The axis of the dynamometer on the greater trochanter of the femur.~* The test parameters included a 0-90 degree range of motion.~* During the isokinetic testing movement, the hip was first flexed from a neutral (starting) position to 90° (for hip flexion) and then the direction of the movement was reversed (for hip extension)~* Angular speed at 120°/s which shows excellent reliability (ICC = 95%) with concentric contraction mode (Contreras et al., 2021) .
Study: NCT06118710

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: Dexamethasone prior to paclitaxel infusion according to local care standards.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: H1 Antihistaminics
Description: Clemastine or Cetirizine prior to paclitaxel infusion according to local care standards

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: H1 Antihistaminics
Description: Clemastine or Cetirizine prior to paclitaxel infusion according to local care standards
Study: NCT06259201

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Vagus Nerve Stimulation
Description: Vagal nerve stimulation (VNS) involves the use of a device to stimulate the vagus nerve with electrical impulses twice per day (AM \& PM) for two minutes each. It is an approved treatment for treatment resistant epilepsy and depression.
Study: NCT06347016

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plozasiran Injection
Description: ARO-APOC3 Injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: sterile normal saline (0.9% NaCl)
Study: NCT05126862

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MindTrails
Description: MindTrails is a web-based cognitive bias modification intervention. Training sessions are designed to encourage cognitive flexibility through repeated practice assigning benign resolutions to ambiguous, anxiety-provoking situations.
Study: NCT06157398

Intervention type: OTHER
Group type: OTHER
Intervention: Increased EPA, DHA, fruit, and vegetable intake
Description: Participants will receive food deliveries for approximately 4-weeks via online ordering, meal delivery, and dietician counseling.
Study: NCT06614868

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Acceptance and Commitment Therapy
Description: Up to 16 session of unstructured counseling therapy informed by Acceptance and Commitment Therapy tradition.
Study: NCT05965362

Intervention type: OTHER
Intervention: Observational; No Interventions were given.
Description: Observational; No Interventions were given.
Study: NCT06695728

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise
Description: It consists of exercises to be done with the exoskeleton. These are; jumping exercise, squat, sit-stand and forward bending exercises.
Study: NCT06696625

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcutaneous Auricular Vagus Nerve Stimulation
Description: taVNS device (Elmmedicare, EC100, Shenzhen, China) was used to apply stimulation for patients.~Stimulation parameters comprised an electrical current of 1 mA at a frequency of 20 Hz, with a waveform width of 1 ms. Repurposed off-the-shelf devices were utilized for this purpose, with the stimulator generating single square-wave pulses lasting 1 ms each. Enhancing conductivity was achieved by wiping the ear with tap water. The electrodes were placed on the cymba conchae and concha around the affected ear, which is the region of rich vagus nerve branch distribution.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneous Auricular Vagus Nerve Stimulation
Description: taVNS device (Elmmedicare, EC100, Shenzhen, China) was used to apply stimulation for patients.~Stimulation parameters comprised an electrical current of 1 mA at a frequency of 20 Hz, with a waveform width of 1 ms. Repurposed off-the-shelf devices were utilized for this purpose, with the stimulator generating single square-wave pulses lasting 1 ms each. Enhancing conductivity was achieved by wiping the ear with tap water. The electrodes were placed on the cymba conchae and concha around the affected ear, which is the region of rich vagus nerve branch distribution.
Study: NCT05893979

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Spectacle Lenses
Description: Standard Spectacle Lenses

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Spectacle Lenses
Description: Standard Spectacle Lenses
Study: NCT04920136

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Strip Free gingival graft (SGG) + Acellular Dermal Matrix graft (ADM)
Description: A horizontal incision is then placed at the middle of residual KT. Two vertical releasing incisions are followed to allow for apical displacement of the flap. The flap will be then elevated with a split-thickness flap beyond the mucogingival junction where it is sutured at this apical position using a mattress (5-0, monocryl) suture. The recipient site should ideally retain intact periosteum that is firmly attached to bone with no loose fibers, no irregularities and no perforations.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Free Gingival graft
Description: Two vertical incisions are made, and a partial thickness flap are designed to provide a firm and immobile periosteal bed. The raised partial thickness flap will be excised. Muscle and unattached connective tissue fibers are thoroughly scraped with a scalpel to prevent graft mobility. Autogenous FGG was harvested with #15C scalpel blade from hard palate at the same side randomly selected to receive the FGG. Donor area was sutured with 5-0 gut sutures. FGG, is placed and stabilized with simple interrupted 5-0 vicryl sutures at recipient site coronal border and horizontal or periosteal anchorage sutures over the graft.
Study: NCT05997680

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Parent-child yoga
Description: The 45-minute yoga sessions are structured to include an opening and a closing ritual that remain the same throughout the 8 weeks, between which an active and a calming parts are scheduled. The active and calming parts are embedded in stories that align with the developmental level and interests typical of 4-to-6-year-olds. Each session is clearly structured with each exercise and transition well described in the Yoga for Little Hearts Yoga Program Manual. In addition to the yoga sessions, at-home exercises (5 min) including breathing, meditation and mindfulness activities will be explained to participants. We will ask them to practice them at home at least 3 times every week, for the 8-week duration of the intervention. Including the yoga session and home exercises, the 8-week intervention thus includes at least 60 minutes of yoga per week. Parents will be encouraged to pursue the at-home exercises after the end of the 8-week yoga program, up to the 6-month follow-up.
Study: NCT04586959

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Surgery with UM
Description: The experimental group will have MIS with the placement of a uterine manipulator

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Surgery without UM
Description: The control group will have MIS without the placement of a uterine manipulator
Study: NCT05959746

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: AI-STROKE application
Description: Complete neurological exam of stroke patients will be filmed by healthcare workers and themselves using the AI-STROKE application
Study: NCT05871606

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: iNO
Description: Inhaled Nitrous Oxide

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: iNO
Description: Inhaled Nitrous Oxide

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: iNO
Description: Inhaled Nitrous Oxide

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: iNO
Description: Inhaled Nitrous Oxide

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: iNO
Description: Inhaled Nitrous Oxide
Study: NCT06430346

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: Physical activity and resistance training
Study: NCT06583239

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Engagement Navigator Service (ENS)
Description: ENS will be a centralized service, staffed by dedicated professional to (1) receive and organize referrals, (2) complete ongoing specialized training in engagement science and evidence-based strategies, (3) provide unbiased support when participants' and/or families' relationships with a CSC program are poor, (4) re-engage participants in CSC or actively connect them with other services if preferred, and (5) continue contact with those who refuse treatment in case they reconsider.
Study: NCT06581796

Intervention type: OTHER
Intervention: pepsinogen-1
Description: association between pepsinogen 1 serum level with hyperemesis gravidarum

Intervention type: OTHER
Intervention: pepsinogen-1
Description: association between pepsinogen 1 serum level with hyperemesis gravidarum
Study: NCT05698459

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: OH2 injection
Description: OH2 injection administered by transcatheter Intraarterial infusion
Study: NCT04975152

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cemiplimab-Rwlc
Description: Flat dose of cemiplimab-rwlc 350 mg IV every 3 weeks, up to 9 cycles.
Study: NCT06513728

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: MPACT Intervention
Description: MPACT has 4 components: accredited training about patient centered, trauma informed methadone treatment, staff education about trauma symptoms with navigation to self screening and treatment or stress management, clinic self assessment tools for trauma informed, patient centered care, and reflective supervision for counselors, case managers and peer staff.
Study: NCT05369403

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lebrikizumab
Description: Administered SC