TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06160336

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Transcutaneous Electrical Nerve Stimulation
Description: Phase 1: Participants undergo a comprehensive assessment in a single experimental session (mapping session) aimed at mapping the regions and sensations that can be electrically stimulated. This mapping protocol is conducted on both the intact and amputated limbs.~Phase 2: This phase comprises a 4-week experimental protocol, including:~1. four mapping sessions conducted at the onset of each week, where the protocol is randomly applied to the participant's intact and amputated limb.~2. three stimulation sessions held over three consecutive days in the initial week to assess the participant's ability to discern stimuli of varying intensities.~3. ten sessions utilizing an end-effector gait rehabilitation robot, aiming to train the participant in walking using the proposed sensory feedback restoration system based on TENS under controlled and repeatable experimental conditions.
Study: NCT05486416

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HSK3486
Description: HSK3486 for induction of general anesthesia

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol
Description: Propofol for induction of general anesthesia
Study: NCT06729580

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioural Activation
Description: 10-week standardized behavioural activation program.
Study: NCT06727981

Intervention type: DRUG
Intervention: ICI plus Chemothearpy
Description: This intervention involves the administration of immune checkpoint inhibitors (ICIs) in combination with standard chemotherapy.

Intervention type: DRUG
Intervention: Chemotherapy
Description: This intervention involves the administration of standard chemotherapy alone.
Study: NCT06729281

Intervention type: DEVICE
Group type: OTHER
Intervention: kinesio tape
Description: The application of kinesio tape is a relatively new method, first developed in 1973 by Kenzo Kase in Japan, also known as elastic bandage, which has become popular in the last 10 years following announcements at major events such as the Olympic Games.
Study: NCT06728124

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GZR18
Description: Used as specified in the protocol

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered the same volume as GZR18
Study: NCT06727487

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Basic recommendations
Description: Daily basis activity counseling by WHO recommendations

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Physical exercise
Description: A complete program of active physical exercise of medium and high intensity

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nutritional advice
Description: A complete program of nutritional counseling

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Psycho-oncological support
Description: A program related with a patient Psycho-oncological follow-up
Study: NCT06728358

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Molecular analyses
Description: Search for molecular alterations that correlate with patient prognosis
Study: NCT06017934

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Volunteer-led physical activity
Description: Participants will be assessed by the therapy team who will prescribe tailored activity and then liaise with the mobility volunteers, who will deliver the intervention. Participants who can mobilise independently will be encouraged to perform walking exercises, progressing their walking distance over set markers in the hospital (e.g., to the end of the bed and back; to the doorway and back; to the toilet and back). Participants who require assistance in mobility will perform bed (e.g., hip abduction, static quads), or chair exercises (e.g., ankle pumps, knee extension, arm raise), and will be progressed to performing walking exercises when their physical function improves. Volunteers will check with nursing staff that participants are safe to exercise before each activity session. Participants will receive the mobility sessions twice daily, starting upon recruitment and continuing until the day of discharge from hospital.
Study: NCT05978141

Intervention type: OTHER
Intervention: Optional Blood Sample and Nail Sample
Description: Participants may provide optional research blood and nail samples for biobanking and future use
Study: NCT06524765

Intervention type: OTHER
Intervention: Living conditions
Description: There are many patients with multi-resistant bacterial infections in intensive care units (ICU), making it possible for a great deal of these pathogens to exist in the ICU environment. The exposure factors in this study were ICU environment or daily living environment.
Study: NCT04731519

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Continuous Identity Cognitive Therapy (CI-CT)
Description: CI-CT was developed as a manualized treatment integrating components of CBT and Acceptance and Commitment Therapy (ACT) with self-continuity and future-self related interventions to help Veterans develop a better present-to-the-future life story as a framework for increasing hopefulness, a sense of life meaning, empowerment, and an ability to attain future self-goals. The recovery oriented CI-CT for post acute suicidal episode Veterans includes eight components: 1) constructing a CI narrative, 2) mindfulness training, 3) life values identification, 4) developing a self-growth perspective, 5) identifying possible future selves - timelines, 6) connecting with the desired future self, 7) CI as context for current problems, and 8) moving toward the future self.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Continuous Identity Cognitive Therapy (CI-CT)
Description: CI-CT was developed as a manualized treatment integrating components of CBT and Acceptance and Commitment Therapy (ACT) with self-continuity and future-self related interventions to help Veterans develop a better present-to-the-future life story as a framework for increasing hopefulness, a sense of life meaning, empowerment, and an ability to attain future self-goals. The recovery oriented CI-CT for post acute suicidal episode Veterans includes eight components: 1) constructing a CI narrative, 2) mindfulness training, 3) life values identification, 4) developing a self-growth perspective, 5) identifying possible future selves - timelines, 6) connecting with the desired future self, 7) CI as context for current problems, and 8) moving toward the future self.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: General Health Education
Description: General Health Education a structured manualized group health education intervention previously developed by VISN 2 MIRECC investigators as a control condition for group psychotherapy RCTs. It has 12 1.5-hour weekly group sessions focusing on health and wellness topics such as Sleep, Physical Activity, Impact of Stress, Relaxation Techniques, Substance Use, Nutrition, Managing Daily Activities, Medication Benefits and Side Effects. GHE was chosen for the AC because it aligns in many respects with CI-CT (e.g., group format, length of sessions, similar expectations) while diverging in specific topics and skills targeted allowing for control of common factors like attention without causing confounding due to overlap in concepts
Study: NCT05767060

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT7104 injection
Description: According to the protocol, each dose group is given intravenous infusion at the rate of mg/kg, and the recommended infusion time is ≥ 60 minutes. Once every two weeks (Q2W), on the first day of each cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT7104 injection
Description: According to the protocol, each dose group is given intravenous infusion at the rate of mg/kg, and the recommended infusion time is ≥ 60 minutes. Once every two weeks (Q2W), on the first day of each cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT7104 injection
Description: According to the protocol, each dose group is given intravenous infusion at the rate of mg/kg, and the recommended infusion time is ≥ 60 minutes. Once every two weeks (Q2W), on the first day of each cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT7104 injection
Description: According to the protocol, each dose group is given intravenous infusion at the rate of mg/kg, and the recommended infusion time is ≥ 60 minutes. Once every two weeks (Q2W), on the first day of each cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT7104 injection
Description: According to the protocol, each dose group is given intravenous infusion at the rate of mg/kg, and the recommended infusion time is ≥ 60 minutes. Once every two weeks (Q2W), on the first day of each cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT7104 injection
Description: According to the protocol, each dose group is given intravenous infusion at the rate of mg/kg, and the recommended infusion time is ≥ 60 minutes. Once every two weeks (Q2W), on the first day of each cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT7104 injection
Description: According to the protocol, each dose group is given intravenous infusion at the rate of mg/kg, and the recommended infusion time is ≥ 60 minutes. Once every two weeks (Q2W), on the first day of each cycle.
Study: NCT04642807

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Long arm soft cast
Description: Participants in group 2 will have a long arm soft cast applied without clinical or radiological follow up.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Long arm full cast
Description: Participants in group 1 will have a long arm full cast applied.
Study: NCT05172960

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SAPIEN X4 THV
Description: Implantation of the SAPIEN X4 valve

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SAPIEN X4 THV
Description: Implantation of the SAPIEN X4 valve
Study: NCT04054401

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: DRG Neurostimulation with Spinal Fusion
Description: Surgeons will implant a neurostimulator during the same open back procedure as fusion devices (spinal fusion hardware and interbody cage) and begin neurostimulation in a short time following surgery (24 hours).
Study: NCT04830566

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Myofascial release technique
Description: Myofascial technique on the thoracolumbar fascia and lumbar paraspinal muscles

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Simulated Myofascial Release technique
Description: Superficial hands contact on the lumbar area
Study: NCT04722029

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Adenovirus Specific T lymphocytes
Description: ADV-VSTs is being proposed for the treatment of refractory ADV infection and/or disease in these populations using haploidentical donors for ease of donor selection, antiviral immunity, coupled with a high-throughput antigen stimulation/IFN-γ capture system (Miltenyi Biotec, CliniMACS Prodigy® System) for rapid and less costly isolation of ADV-VSTs.
Study: NCT05414851

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Whole-Food, Plant-Based Diet and Low-Carbohydrate Diet
Description: Participants will consume two weeks of each diet, with a 4-6 week washout period in between. Meals and snacks are provided for convenience to enhance adherence to each dietary pattern, but subjects can add or include their own home-prepared foods as long as they meet dietary guidelines. Each dietary intervention will include an education session via Zoom teleconference, and at least 2 individual contacts by phone to address questions and assess for adverse events.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Whole-Food, Plant-Based Diet and Low-Carbohydrate Diet
Description: Participants will consume two weeks of each diet, with a 4-6 week washout period in between. Meals and snacks are provided for convenience to enhance adherence to each dietary pattern, but subjects can add or include their own home-prepared foods as long as they meet dietary guidelines. Each dietary intervention will include an education session via Zoom teleconference, and at least 2 individual contacts by phone to address questions and assess for adverse events.
Study: NCT06448052

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: umbilical cord mesenchymal stem cell
Description: A total of 100 million single cells were suspended in 0.9% sterile saline solution and given intravenously at a 5-ml/min rate for 45 min. All patients will get two intravenous autologous infusions on days 0 (D0) and 90 (D90).
Study: NCT06188897

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Self-stretching of the masticatory musculature
Description: If the subject belonged to the Treatment group, he was instructed to self-stretch the masticatory muscle.~This stretch consisted of introducing three knuckles of the non-dominant hand between the incisors for two minutes while sitting.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Control group intervention
Description: The control group was asked to introduce only two knuckles in the oral cavity and perform a mandibular occlusion, an intervention that serves as a simulated stretch in said group.
Study: NCT04777370

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: posterior glide mobilization
Description: The participant will be positioned supine on a plinth, with their scapula stabilized against a firm wedge on the table, and the shoulder joint in the resting position (approx. 55 degrees abduction, 30 degrees horizontal adduction, and slight external rotation). With the extremity held in the same position, the researcher will then apply a grade III (into tissue stretch) PG mobilization. This will consist of five 30-second bouts of sustained gr III posterior glide mobilizations.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sleeper stretch
Description: All participants randomized to the stretching group will perform five 30-second holds of the sleeper stretch. This is performed by lying on the side to be stretched, elevating the upper arm to 90° on the support surface with the elbow bent 90°, then passively internally rotating the shoulder with force provided by with the opposite arm.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: thoracic manipulation
Description: Individuals will then undergo a single supine grade V thrust manipulation. All manipulations will take place at the T3-4 segment. If a cavitation (pop) is not heard or felt by either the subject or examiner, a second thrust will be performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: thoracic manipulation
Description: Individuals will then undergo a single supine grade V thrust manipulation. All manipulations will take place at the T3-4 segment. If a cavitation (pop) is not heard or felt by either the subject or examiner, a second thrust will be performed.
Study: NCT05619653

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Prednisolone
Description: randomised double-blind, placebo-controlled clinical trial 1:1 randomisation

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Prednisolone
Description: randomised double-blind, placebo-controlled clinical trial 1:1 randomisation

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Losartan
Description: randomised double-blind, placebo-controlled clinical trial 1:1 randomisation

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Losartan
Description: randomised double-blind, placebo-controlled clinical trial 1:1 randomisation
Study: NCT05505240

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Respiratory analysis at cold temperature
Description: Respiratory analysis at an ambient temperature of 18°C

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Respiratory analysis at room temperature
Description: Respiratory analysis at an ambient temperature of 22°C

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Respiratory analysis at thermoneutral temperature
Description: Respiratory analysis at an ambient temperature of 28°C

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Respiratory analysis at hot temperature
Description: Respiratory analysis at an ambient temperature of 38°C
Study: NCT05362864

Intervention type: PROCEDURE
Intervention: Fracture fixation via Intramedullary Nailing
Description: Fixation of trochanteric, sub-trochanteric, and shaft fractures and osteotomies.
Study: NCT05445453

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Museum visit
Description: The intervention is a visit of the MMFA. This visit can be done alone or accompanied.~The visit of the MMFA is free for the patient.
Study: NCT06013696

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Adding household bleach to urine sample
Description: Adding household bleach to urine sample

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Adding household bleach to urine sample
Description: Adding household bleach to urine sample
Study: NCT05698576

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TRANBERG® Transperineal Fusion Laser--Induced Thermal Therapy of Prostate Cancer (TPF-LITT)
Description: A perineal local anesthesia block is performed with patient on lithotomy. The ultrasound probe is advanced, secured to digital stepper. The live ultrasound image feed is visible on the FOCALYX® Fusion device. Image co-registration (MR/US) will be performed. The FOCALYX® Fusion device shows outline of the prostate on the MRI and the target area(s) in real-time. The urologist advances laser fiber introducer, temperature probes to indicated coordinates. Target treatment - applying TRANBERG® laser energy over the treatment area and controlling delivery with a pedal. Treatment is monitored using FOCALYX® Fusion device in real-time. One laser fiber will be used and a single or multiple applications may be required. The fiber will be relocated to other targets if present. Patient will be dismissed to the MRI center where a multiparametric MRI will be conducted. After this study is completed, the patient will be discharged home with instructions and contact information.
Study: NCT05742334

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Robot-Assisted Radical Prostatectomy with MLG-COMPLETE Allograft Implantation
Description: The intervention will be administered on an inpatient basis. Participants receiving MLG-Complete™ will have it placed around the neurovascular bundle. Placement of the graft should not take more than 5 minutes, therefore, there should be minimal impact to overall surgical time.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MLG-COMPLETE Allograft Implantation
Description: The MLG-Complete™ allograft will be placed on each neurovascular bundle (NVB) bilaterally as shown on the above picture after excision of the prostate prior to completing the urethrovesical anastomosis.
Study: NCT06331468

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: A total of two IV infusions of cisplatin will be administered on Day 1 and again on Day 8 +/- 1 day. Cisplatin starting dose is 40 mg/m2. Dose reduction is allowed (30 mg/m2) as needed for management of toxicities.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: intensity modulated radiation therapy (IMRT)
Description: given once daily Monday-Thursday, four fractions per week for 2 weeks. The radiation dose is 4.56 Gy x 8 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: high-dose-rate (HDR) brachytherapy
Description: administered 2x weekly (allow at least 72-hours window between sessions); weekdays only for 2 weeks. The radiation dose is 7 Gy x 4 fractions.
Study: NCT05586477

Intervention type: DRUG
Group type: OTHER
Intervention: Placebo
Description: A placebo pill (i.e., sugar) will be consumed 2 h before intervention.

Intervention type: DRUG
Group type: OTHER
Intervention: Placebo
Description: A placebo pill (i.e., sugar) will be consumed 2 h before intervention.

Intervention type: DRUG
Group type: OTHER
Intervention: Diphenhydramine
Description: Extra strength Benadryl (DIN 02470144) will be consumed 2 h before intervention

Intervention type: DRUG
Group type: OTHER
Intervention: Diphenhydramine
Description: Extra strength Benadryl (DIN 02470144) will be consumed 2 h before intervention
Study: NCT04192695

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cytosponge cell collection device
Description: The Cytosponge™ is a minimally-invasive sampling device consisting of a polyurethane sponge compressed in a cellophane capsule attached to a string. When swallowed, the capsule dissolves in the stomach, releasing the cell collection sponge that expands to 3 cm in diameter. Next, a nurse or qualified medical technician retrieves the sponge by pulling back on the string and retracting it through the mouth. During extraction, the rough texture on the surface of the sponge collects epithelial cells in the cardia and along the entire length of the esophagus. Cytosponge™ has excellent safety profile and is approved by the Food and Drug Administration (FDA) and the Healthcare Products Regulatory Agency (HPRA) in the UK.
Study: NCT05305729

Intervention type: OTHER
Intervention: No intervention
Description: No intervention
Study: NCT05235438

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IMM27M
Description: IMM27M injection
Study: NCT06211556

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Very-low calorie diet
Description: \~800 kcal/day delivered via commercially available diet plan (NUPO).
Study: NCT05359471

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Bone densitometry
Description: It is the standard method for diagnosing osteoporosis. In the central DXA examination, which measures bone density of the hip and spine, the patient lies on a padded table.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Bone densitometry
Description: It is the standard method for diagnosing osteoporosis. In the central DXA examination, which measures bone density of the hip and spine, the patient lies on a padded table.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Questionnaires
Description: Smoking and drug related questionnaires will be used as variable to see dependence, how it impacts participants activities/health or determining whether they are light/moderate/heavy smoker

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Questionnaires
Description: Smoking and drug related questionnaires will be used as variable to see dependence, how it impacts participants activities/health or determining whether they are light/moderate/heavy smoker

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Review of medical chart
Description: History of previous liver diseases including hepatitis B, C, and HIV

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Review of medical chart
Description: History of previous liver diseases including hepatitis B, C, and HIV