TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05992337

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sampling
Description: Blood sample collection for mRNA determination

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sampling
Description: Blood sample collection for mRNA determination

Intervention type: DIAGNOSTIC_TEST
Intervention: Echocardiography
Description: Echocardiography for detection of ventricular dysfunction

Intervention type: DIAGNOSTIC_TEST
Intervention: Echocardiography
Description: Echocardiography for detection of ventricular dysfunction

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardio MRI
Description: MRI for early detection of myocardial impairment caused by chemotherapy

Intervention type: DIAGNOSTIC_TEST
Intervention: 24-hours monitoring of ECG
Description: Diagnostic test for detection of arrhythmias as a consequence of cardiotoxicity

Intervention type: DIAGNOSTIC_TEST
Intervention: 24-hours monitoring of ECG
Description: Diagnostic test for detection of arrhythmias as a consequence of cardiotoxicity

Intervention type: DIAGNOSTIC_TEST
Intervention: 24 hours monitoring of BP
Description: Diagnostic test for detection of hypertension as a consequence of cardiotoxicity
Study: NCT06368297

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ketone Monoester Supplementation
Description: Exogenous ketones are a class of ketone bodies that are ingested using nutritional supplements or foods. This class of ketone bodies refers to the three water-soluble ketones (acetoacetate, β-hydroxybutyrate \[β-HB\], and acetone).

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ketone Monoester Supplementation
Description: Exogenous ketones are a class of ketone bodies that are ingested using nutritional supplements or foods. This class of ketone bodies refers to the three water-soluble ketones (acetoacetate, β-hydroxybutyrate \[β-HB\], and acetone).

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ketogenic diet
Description: The ketogenic diet typically reduces total carbohydrate intake to less than 50 grams a day-less than the amount found in a medium plain bagel-and can be as low as 20 grams a day. Generally, popular ketogenic resources suggest an average of 70-80% fat from total daily calories, 5-10% carbohydrate, and 10-20% protein.
Study: NCT04942626

Intervention type: DRUG
Group type: OTHER
Intervention: Kineret 100 MG in 0.67 ML Prefilled Syringe
Description: Anakinra 100 mg s.c. (Kineret) will be administered from day -10 (i.e. 10 days before initiation of RT) to the last day of RT.

Intervention type: DRUG
Group type: OTHER
Intervention: Capecitabine
Description: Capecitabine will be administered using a 3+3 dose escalation design (500 mg/m2 bid, 650 mg/m2 bid and 825 mg/m2 bid po, respectively) from day 1 to day 40 of RT including weekends.

Intervention type: RADIATION
Group type: OTHER
Intervention: Radiotherapy
Description: PTV: 1.8 Gy to 45 Gy (#28 fractions) to the primary tumor and pelvic lymph nodes; followed by a sequential boost of 1.8 Gy to 9 Gy (#5 fractions) to the gross tumor volume

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Watch and Wait (cCR) or TME surgery (non-cCR)
Description: Restaging to evaluate tumor response will be conducted 10 weeks after completion of CRT. For patients achieving a clinical complete response (cCR), a Watch and Wait (W\&W) option with close follow-up is scheduled. In case of non-cCR, immediate total mesorectal excision (TME) surgery is recommended. According to the current German S3-guidelines, adjuvant chemotherapy is optional.
Study: NCT06410482

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: US guided caudal block
Description: After placing the patient in the left lateral position (hips and knees flexed) following monitoring and induction of anaesthesia, the field will be sterilized with 70% alcohol in 2% chlorhexidine.~Initial scanning in the transverse plane allows for visualization of the midline and identification of the sacrococcygeal ligament between the 2 sacral cornua. The 2 cornua resemble the 2 eyes of a frog and thus are collectively called the frog-eye sign. The US probe is then rotated 90 degrees to acquire a longitudinal view. The needle is then advanced at a 20-degree angle with needle tip and length visualization Once the needle is confirmed to be in the caudal space on the screen, carefully aspirate to confirm absence of CSF or blood.~A slow injection of the local anaesthetic can then be performed, dose of (0.2 mL/kg 0.25% bupivacaine and 1 μg/kg of dexmedetomidine

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Dorsal penile nerve block
Description: after general anesthesia induction. With the patient in the supine position. After skin sterilization the US linear probe will be transversely placed on the root of the penis. After placing the penis in gentle traction, a50 mm block needle will be inserted from the lateral part of the penis root towards the dorsal section of the penis with the in-plane technique, It will be advanced through Dartos fascia until resistance to the needle disappeared.~Once the superficial sheath will be passed, the tip of the needle will be advanced into Buck's fascia and then positioned between Buck's fascia and tunica albuginea, lateral to the dorsal artery. After making sure there will be no blood with negative aspiration, half of the total 0.2 mL/kg dose of 0.25% bupivacaine will be administered while observing its distribution with US. The same procedure will be then repeated on the other side of the penis.
Study: NCT05846100

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Preprocedural spinal ultrasound
Description: a preprocedural spinal ultrasound was performed in a non sterile manner with a sitting position.Both paramedian and transverse planes The intersection of the longitudinal and transverse lines is the point of needle insertion The distance from the skin to the dura mater is noted

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: fictional preprocedure spinal ultrasound
Description: fictional preprocedure spinal ultrasound Fictional ultrasound identification Screen device shut down
Study: NCT04742725

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prothione™ (6g)
Description: Prothione is a pro-Glutathione compound includes free-form amino acids
Study: NCT05933733

Intervention type: OTHER
Intervention: Salvage treatment (surgery and/or radiation therapy)
Description: Appropriate salvage treatment (surgery and/or radiation therapy) will be selected by the treating clinicians considering the disease status.
Study: NCT05402865

Intervention type: DRUG
Intervention: Denosumab
Description: Denosumab, subcutaneous injection, specific usage to see the medical records. Non-denosumab, specific usage to see the medical records.
Study: NCT06034600

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: taping
Description: Taping will be applied to the exercise and taping group after the exercises with theraband. Other exercises that are not performed will be performed with the tape on the skin.The application will be repeated three days a week for eight weeks.
Study: NCT06084325

Intervention type: DEVICE
Intervention: Respiration resistance sensitivity task (RRST)
Description: The RRST measures interoception on the domain of the breath and thus allows its (non-invasive) manipulation. The RRST apparatus includes a step motor that moves a wedge piece back and forth to change the obstruction level in the breathing circuit. This fully automated apparatus will change the breathing obstruction level via a computer-controlled algorithm. The patient breath by the month though this device.

Intervention type: DEVICE
Intervention: Respiration resistance sensitivity task (RRST)
Description: The RRST measures interoception on the domain of the breath and thus allows its (non-invasive) manipulation. The RRST apparatus includes a step motor that moves a wedge piece back and forth to change the obstruction level in the breathing circuit. This fully automated apparatus will change the breathing obstruction level via a computer-controlled algorithm. The patient breath by the month though this device.
Study: NCT06279936

Intervention type: OTHER
Intervention: Neuropsychological battery
Description: COVID-19 patients with persistent complaints of cognitive disabilities (more than 4 weeks post-infection) in daily life are examined with an extensive neuropsychological test battery (see below) at the outpatient clinic of the University Psychiatric Centre in Duffel and at the University Hospital Antwerp. This battery covers a broad range of reliable and valid tests divided into six cognitive domains: attention, memory, visuospatial functions, language, executive functions and psychomotor speed/coordination. The neuropsychological examination lasts an average of 2 hours per participant. The tests are carried out by the same experienced neuropsychologist and also follow a standardized sequence. In addition to the neuropsychological assessment, two self-report scales are filled out by each patient. These scales are used to detect possible complaints of fatigue and possible cognitive problems which are experienced by the patient during daily life activities.
Study: NCT06084325

Intervention type: BEHAVIORAL
Intervention: Heartbeat Tracking (HBT)
Description: The HBT measures interoception on the domain of the cardiovascular system, by assessing how accurate participants perceive their own heartbeat. After each time window participants will be asked how many heartbeats they counted, which will be compared to the actual heartbeat measured via electrocardiography (ECG).

Intervention type: BEHAVIORAL
Intervention: Heartbeat Tracking (HBT)
Description: The HBT measures interoception on the domain of the cardiovascular system, by assessing how accurate participants perceive their own heartbeat. After each time window participants will be asked how many heartbeats they counted, which will be compared to the actual heartbeat measured via electrocardiography (ECG).

Intervention type: DEVICE
Intervention: Heartbeat evoked potential (HEP)
Description: The HEP is computed by averaging EEG signals time-locked to specific peaks of simultaneously measured ECG signals. Therefore both an ECG and an EEG will be set up for the participants. The task during the HEP is to simply focus on interoceptive tones (the own heartbeat) with a control condition of focusing on exteroceptive tones (sounds played). A further condition of HEP measurement is the cardio-audio synchronization. Hereby, participants will be instructed to passively listen to sounds presented to them via in-ear phones while further fixating the cross.

Intervention type: DEVICE
Intervention: Heartbeat evoked potential (HEP)
Description: The HEP is computed by averaging EEG signals time-locked to specific peaks of simultaneously measured ECG signals. Therefore both an ECG and an EEG will be set up for the participants. The task during the HEP is to simply focus on interoceptive tones (the own heartbeat) with a control condition of focusing on exteroceptive tones (sounds played). A further condition of HEP measurement is the cardio-audio synchronization. Hereby, participants will be instructed to passively listen to sounds presented to them via in-ear phones while further fixating the cross.

Intervention type: DEVICE
Intervention: Libet task
Description: Additionally we also link the interoceptive domain of the breath to a well-known and established agency task measuring conscious intention. Participants will do two versions of the Libet taks while simultaneously recording their EEG and breathing signals with a respiratory belt.

Intervention type: DEVICE
Intervention: Libet task
Description: Additionally we also link the interoceptive domain of the breath to a well-known and established agency task measuring conscious intention. Participants will do two versions of the Libet taks while simultaneously recording their EEG and breathing signals with a respiratory belt.
Study: NCT05990322

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Project EMPOWER
Description: Experimental Condition

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Project EMPOWER
Description: Experimental Condition
Study: NCT04988269

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sampling
Description: Assessment of circulating levels of plasma ACTH, plasma aldosterone and serum interleukin -6 levels at day 1

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sampling
Description: Assessment of circulating levels of plasma ACTH, plasma aldosterone and serum interleukin -6 levels at day 1

Intervention type: DIAGNOSTIC_TEST
Intervention: Saliva sampling
Description: Assessment of diurnal variation of cortisol and DHEA levels in the saliva at 4 different time points during the day (0.800, 12.00, 18.00, 22.00) at day 2.

Intervention type: DIAGNOSTIC_TEST
Intervention: Saliva sampling
Description: Assessment of diurnal variation of cortisol and DHEA levels in the saliva at 4 different time points during the day (0.800, 12.00, 18.00, 22.00) at day 2.
Study: NCT04717752

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ovidrel
Description: recombinant human chorionic gonadotropin for injection

Intervention type: DRUG
Group type: SHAM_COMPARATOR
Intervention: Ovidrel
Description: recombinant human chorionic gonadotropin for injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Troprilin
Description: triptorelin acetate injection
Study: NCT06279936

Intervention type: OTHER
Intervention: Saliva swabs
Description: Salivary cortisol measures will be used as functional measure of the HPA axis activity, as the unbound cortisol fraction in saliva is highly correlated to plasma cortisol. Baseline diurnal cortisol and CAR levels will be measured using saliva, collected at home with Salivette® (Sarstedt) synthetic swabs. The rationale behind the choice of home sampling, is to maximize normal circumstances and to minimize stress related to the measuring procedure.

Intervention type: OTHER
Intervention: Saliva swabs
Description: Salivary cortisol measures will be used as functional measure of the HPA axis activity, as the unbound cortisol fraction in saliva is highly correlated to plasma cortisol. Baseline diurnal cortisol and CAR levels will be measured using saliva, collected at home with Salivette® (Sarstedt) synthetic swabs. The rationale behind the choice of home sampling, is to maximize normal circumstances and to minimize stress related to the measuring procedure.
Study: NCT06034600

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise
Description: Stretching and strengthening exercises will be applied to both groups three days a week for 8 weeks.The exercises performed with theraband will be performed in the same way in both groups. While the other exercises will be done after taping in the taping and exercise group, the exercise group will be done without taping.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise
Description: Stretching and strengthening exercises will be applied to both groups three days a week for 8 weeks.The exercises performed with theraband will be performed in the same way in both groups. While the other exercises will be done after taping in the taping and exercise group, the exercise group will be done without taping.
Study: NCT06403592

Intervention type: OTHER
Intervention: optic nerve sheath diamater
Description: Measurement of optic nerve sheath diameter
Study: NCT05635214

Intervention type: PROCEDURE
Intervention: real time remote tele mentored ultrasound exam
Description: A patient will have a point of care ultrasound exam performed by a local provider with a remote expert guiding them through the exam using video conferencing.
Study: NCT06288113

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo collection of blood samples

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo PET/CT and SPECT/CT

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gallium Ga 68 Gozetotide
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lutetium Lu 177 Vipivotide Tetraxetan
Description: Given IV

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo PET/CT

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaire Administration
Description: Ancillary studies

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Single Photon Emission Computed Tomography
Description: Undergo SPECT/CT
Study: NCT06365736

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Contemplating in nature
Description: Participants will spend 30 minutes in nature per day for 10 times over 14 days.~Each time, participants will walk for 10 minutes and then choose a nice spot to sit for 10 minutes. During these minutes they will be asked to be silently present and observe trees, plants, flowers or other aspects of nature and contemplate their connectedness to nature and their own awareness. Then walk back 10 minutes.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Walking in nature
Description: Participants will be asked to walk for 30 minutes in nature per day for 10 times over 14 days without further instruction.
Study: NCT06223945

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Prevention algorithm
Description: Development of an algorithm for the prevention of thrombohemorrhagic complications

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Prevention algorithm
Description: Development of an algorithm for the prevention of thrombohemorrhagic complications
Study: NCT06432127

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Unilateral Greater occipital nerve block at C2 level under ultrasound guide with needle in plane technique during ultrasound using normal saline 3 mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine
Description: Unilateral Greater occipital nerve block at C2 level under ultrasound guide with needle in plane technique during ultrasound using 0.5% Bupivacaine 3 mL
Study: NCT05461092

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thoracolumbar Interfascial Plane (TLIP) Block of bupivacaine
Description: Patient receives standard of care anesthesia with TLIP Block of bupivicaine (local anesthetic) intraoperatively after anesthesia administration and before spinal fusion.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Blood Test
Description: Blood Tests measuring inflammatory markers: IL-10, MCP-1, IL-8, IL-6, TNFa

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Blood Test
Description: Blood Tests measuring inflammatory markers: IL-10, MCP-1, IL-8, IL-6, TNFa

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 3D CAM Delirium Severity Scoring
Description: Questionnaire that will rate each symptom of delirium

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 3D CAM Delirium Severity Scoring
Description: Questionnaire that will rate each symptom of delirium

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Generalized Anxiety Disorder 7-item (GAD-7) scale
Description: Questionnaire for screening and severity measurement of generalized anxiety disorder.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Generalized Anxiety Disorder 7-item (GAD-7) scale
Description: Questionnaire for screening and severity measurement of generalized anxiety disorder.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Numerical Rating Score (NRS)
Description: Questionnaire assessing pain intensity

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Numerical Rating Score (NRS)
Description: Questionnaire assessing pain intensity

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PROMIS-Pain Interference
Description: Questionnaire measuring the effect of pain on patient physical, emotional, and social functioning.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PROMIS-Pain Interference
Description: Questionnaire measuring the effect of pain on patient physical, emotional, and social functioning.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Oswestry Disability Index (ODI)
Description: Questionnaire assessing disability and quality of life impairment in adults with lower back pain.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Oswestry Disability Index (ODI)
Description: Questionnaire assessing disability and quality of life impairment in adults with lower back pain.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Saint Louis University Mental Status Examination (SLUMs)
Description: Questionnaire assessing baseline cognition.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Saint Louis University Mental Status Examination (SLUMs)
Description: Questionnaire assessing baseline cognition.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Delirium Rating Scale-Revised-98 (DRS)
Description: 16 item clinician rated scale assessing delirium severity.
Study: NCT04956744

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMS001
Description: IMS001 is a human embryonic cell derived (hESC) mesenchymal stem cell (MSC).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMS001
Description: IMS001 is a human embryonic cell derived (hESC) mesenchymal stem cell (MSC).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMS001
Description: IMS001 is a human embryonic cell derived (hESC) mesenchymal stem cell (MSC).
Study: NCT05261087

Intervention type: OTHER
Intervention: No intervention
Description: Individuals will not receive any interventions
Study: NCT04965038

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Alteplase
Description: Intravenous thrombolysis with alteplase within 4.5 hours of symptom onset
Study: NCT05219318

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Combination PD-1/PD-L1 ICI + VEGFR-TKI
Description: The study will enroll patients achieving an objective response beween the end of the 11th month and the end of the 13th month of treatment with the combination PD-1/PD-L1 ICI + VEGFR-TKI as recommended in the Summary of Product Characteristics (SmPC)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treatment pause
Description: Combination regimens discontinuation until progression with the possibility to resume initial combination regimens at progression
Study: NCT06496256

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Barrigel
Description: Barrigel is an absorbable gel based on Non-Animal Stabilized Hyaluronic Acid (NASHA™) that is injected into the peri-rectal space

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transrectal Ultrasound
Description: All subjects will have a transrectal ultrasound (TRUS) conducted. In the control subjects this will act as a sham procedure. For the investigational subjects, the TRUS will be used to visualize the placement of the needle

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transrectal Ultrasound
Description: All subjects will have a transrectal ultrasound (TRUS) conducted. In the control subjects this will act as a sham procedure. For the investigational subjects, the TRUS will be used to visualize the placement of the needle