TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06221670

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab
Description: This is a prospective, open, single-center, single-arm phase II clinical study with no driver mutations identified in the central laboratory，to evaluate the efficacy and safety of adjuvant Toripalimab therapy in completely resected stage IA2-IB non-squamous NSCLC with high-risk factors.
Study: NCT06195956

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: exercise
Description: Exercises done 3 times per weeks, 3 repetitions per exercise for 3 months

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise
Description: Exercises done 3 times per weeks, 3 repetitions per exercise for 3 months
Study: NCT04667572

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
Description: Riboflavin will be used to load the cornea, followed by UV-A crosslinking of the cornea

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: PXL-330 Platinum device for crosslinking with Peschke riboflavin solution
Description: Riboflavin will be used to load the cornea, followed by UV-A crosslinking of the cornea
Study: NCT04603560

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Audit and Feedback
Description: A report of the provider's hypertension control rates compared to benchmark will be displayed using principles of social norming. We will present that provider's hypertension control rates compared to the 90th percentile of their peers.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Pharmacist E-Detailing
Description: A pharmacist will review the chart in advance and provide a personalized recommendation for how to intensify the specific patient's antihypertensive regimen based on current guidelines. For example, they might recommend adding an additional medication based on the patient's comorbid conditions and could suggest a starting dose and timeframe for dose escalation.
Study: NCT06650566

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LM-299
Description: Administered intravenously

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LM-299
Description: Administered intravenously

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LM-299
Description: Administered intravenously
Study: NCT06093763

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Group without bone grafting
Description: Open wedge corrective osteotomy and plate fixation without bone grafting.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Group with bone grafting
Description: Open wedge corrective osteotomy and plate fixation with harvesting and using bone from the iliac crest.
Study: NCT06650566

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LM-299
Description: Administered intravenously
Study: NCT05346718

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ragweed pollen, birch pollen, clean air (placebo)
Description: Participants are exposed for 4 hours in the Fraunhofer Allergen Challenge Chamber with varying pollen concentrations of ragweed or birch pollen and once with clean air, serving as a placebo exposure.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ragweed pollen, birch pollen, clean air (placebo)
Description: Participants are exposed for 4 hours in the Fraunhofer Allergen Challenge Chamber with varying pollen concentrations of ragweed or birch pollen and once with clean air, serving as a placebo exposure.
Study: NCT06637241

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Risk stratification care
Description: In this group, Taiwanese adolescent baseball players are categorized into high-risk, medium-risk, and low-risk groups based on injury risk from a previous study. High-risk players receive sports protection education and physician referrals for shoulder and elbow assessments, with further imaging if necessary. Common issues like Little League shoulder and elbow are managed with conservative treatments. The sports protection education includes the Modified Yokohama Baseball-9 (mYKB-9), a program that significantly reduces injuries with exercises targeting shoulder and elbow health. Medium-risk players receive mYKB-9 education only, while low-risk players are observed without changes to their training methods.
Study: NCT06662695

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ginger-based supplement
Description: Ginger-based supplement in a dosage of 1500 mg

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Capsules containing corn flour
Study: NCT06597344

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gepotidacin
Description: Gepotidacin will be administered.
Study: NCT06591728

Intervention type: DIETARY_SUPPLEMENT
Group type: OTHER
Intervention: Oral PCA
Description: Administration of 1,000 mg BID of oral PCA in individuals with knee prosthetic joint infection prior to revision surgery
Study: NCT05462821

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Eye Patch
Description: adhesive patch to cover eye
Study: NCT06669039

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Computer-controlled Local Anesthetic delivery system
Description: Local anesthesia will be delivered using Computer-controlled Local Anesthetic delivery system.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Inferior Alveolar Nerve Block
Description: Local anesthesia will be delivered using the conventional syringe
Study: NCT04661358

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fenofibrate
Description: Participants begin with a dose of either 160mg or 54mg fenofibrate, based on eGFR value at screening, taken once daily with food. The dose may be adjusted during follow-up based on protocol guidelines.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants begin with a dose of either 160mg or 54mg placebo, based on eGFR value at screening, taken once daily with food. The dose may be adjusted during follow-up based on protocol guidelines.
Study: NCT06670417

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Low level laser therapy watch: The laser watch device was a semiconductor LLL therapeutic apparatus, (model:SL-03 GaALAs semiconductor) Domer Laser Therapy Watch class 3B 650nm low-level laser light
Description: Low level laser therapy watch:~The laser watch device was a semiconductor LLL therapeutic apparatus, (model:SL-03 GaALAs semiconductor) Domer Laser Therapy Watch class 3B 650nm low-level laser light. It provides 18 individual laser beams used for extravascular blood irradiation (transcutaneous) through radial and ulnar vessels at the wrist site.
Study: NCT05526391

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TAK-341
Description: TAK-341 IV infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TAK-341
Description: TAK-341 IV infusion

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: TAK-341 placebo-matching IV infusion

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: TAK-341 placebo-matching IV infusion
Study: NCT04943718

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: personalized vaccine
Description: Based on genetic and transcriptional sequencing information, personalized peptide vaccines would be designed and produced; patients would be vaccinated on day 1, 4, 8 ,15, 22 and then on week 12, 20.
Study: NCT06670417

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Buerger Allen exercise
Description: Procedure-Keep the Buerger Allen exercise board on the cot. Elevate the lower extremities to an angle of 45 to 90 degree with the help of exercise board. Provided support to the lower extremities to maintain the position. Make the subject to maintain the same position in the same manner until the skin blanches (appears dead white). Lower the feet and the legs below the level of the rest of the body until redness appears (care should be taken that there is no pressure against the back of the knees). Place the legs flat on the bed for a few minutes. Ask the subjects to sit in a relaxed position while each foot is flexed and extended then inverted and everted for 3 minutes till the feet turns entirely pink. Ask the subject to rotate the feet in all the direction. Make the subject to lie quietly for 5 minutes, keeping legs warm with a blanket

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Regular wound care
Description: Regular wound care and dressing to the wound and ulcer
Study: NCT06675721

Intervention type: OTHER
Intervention: Study Questionnaire
Description: A survey questionnaire to assess factors related to vaccination adherence, including factors such as vaccine novelty, cost, and prior knowledge among vulnerable populations.

Intervention type: OTHER
Intervention: Study Questionnaire
Description: A survey questionnaire to assess factors related to vaccination adherence, including factors such as vaccine novelty, cost, and prior knowledge among vulnerable populations.
Study: NCT06675630

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Education
Description: Consumers will receive monthly targeted educational materials on fibre

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Control
Description: Consumers will receive educational materials on healthy eating at two timepoints
Study: NCT06675656

Intervention type: OTHER
Intervention: DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood.
Description: DNA extraction from urine, stool and biopsy for microbiome analysis. Isolation of peripheral blood mononuclear cells from peripheral blood for immunophenotypic analysis, and isolation of serum for analysis of cytokines and bacterial metabolites.

Intervention type: OTHER
Intervention: DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood.
Description: DNA extraction from urine, stool and biopsy for microbiome analysis. Isolation of peripheral blood mononuclear cells from peripheral blood for immunophenotypic analysis, and isolation of serum for analysis of cytokines and bacterial metabolites.

Intervention type: OTHER
Intervention: DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood.
Description: DNA extraction from urine, stool and biopsy for microbiome analysis. Isolation of peripheral blood mononuclear cells from peripheral blood for immunophenotypic analysis, and isolation of serum for analysis of cytokines and bacterial metabolites.

Intervention type: OTHER
Intervention: DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood.
Description: DNA extraction from urine, stool and biopsy for microbiome analysis. Isolation of peripheral blood mononuclear cells from peripheral blood for immunophenotypic analysis, and isolation of serum for analysis of cytokines and bacterial metabolites.

Intervention type: OTHER
Intervention: DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood.
Description: DNA extraction from urine, stool and biopsy for microbiome analysis. Isolation of peripheral blood mononuclear cells from peripheral blood for immunophenotypic analysis, and isolation of serum for analysis of cytokines and bacterial metabolites.

Intervention type: OTHER
Intervention: DNA extraction from urine, stool and biopsy. Isolation of serum and PBMC from peripheral blood.
Description: DNA extraction from urine, stool and biopsy for microbiome analysis. Isolation of peripheral blood mononuclear cells from peripheral blood for immunophenotypic analysis, and isolation of serum for analysis of cytokines and bacterial metabolites.
Study: NCT05235477

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Tube technique
Description: An excavator (smaller than the width of the defect; evaluated pre-surgically on a study model) is used to carefully reflect the papilla away from the alveolar bone and root surfaces on the buccal aspect to access the interproximal region to prepare the bed for the graft. The excavator is used to do the same on the palatal aspect. The amount of reflection should yield a very relaxed papilla flap that permits placement of the papilla at the new coronal position without tension. The recipient site at this time should resemble a tube with two openings; one on the buccal aspect at the mucogingival junction and one on the palatal aspect.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tube technique
Description: An excavator (smaller than the width of the defect; evaluated pre-surgically on a study model) is used to carefully reflect the papilla away from the alveolar bone and root surfaces on the buccal aspect to access the interproximal region to prepare the bed for the graft. The excavator is used to do the same on the palatal aspect. The amount of reflection should yield a very relaxed papilla flap that permits placement of the papilla at the new coronal position without tension. The recipient site at this time should resemble a tube with two openings; one on the buccal aspect at the mucogingival junction and one on the palatal aspect.
Study: NCT06674798

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: School-based eHealth NCD Prevention Program
Description: Students will participate in health-promoting sessions delivered by trained facilitators, with each session lasting 30 to 40 minutes. There will be a total of six health-promoting sessions conducted in the classroom for the intervention group, spanning two months with three sessions per month. The health-promoting videos from the school-based eHealth NCD prevention program will be shown in the classroom using multimedia. The drama-based videos will be developed in Urdu Language with English subtitles and will be based on based on contextually relevant content for the Pakistani secondary and higher secondary school students of age 13 to 18 years old. The content of these six sessions will be focused on the leading risk factors associated with NCDs as reported by different studies such as physical inactivity, unhealthy diet and overweight, obesity, harmful alcohol consumption and tobacco use.
Study: NCT06673875

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: conservative treatment of stress urinary incontinence - pelvic floor muscle training
Description: evaluation of pelvic floor muscle rehabilitation to change the clinical severity of urinary incontinence

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: vaginal device Aniball INCO
Description: the firt group - the pelvic floor muscle training with vaginal device Aniball INCO according manual after education by the urogynecologist, who is educated in pelvic floor dysfunction.~the second group - the pelvic floor muscle training without vaginal device, the education was performed by certified physiotherapist trained in pelvic floor disorder.
Study: NCT04840186

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Liver-resection or ablation
Description: Liver-resection of colorectal liver metastasis. Ablation can be used as adjunct to surgery.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 2nd line chemotherapy
Description: 2nd line chemotherapy. Type of chemotherapy is determined by treating oncologist

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 2nd line chemotherapy
Description: 2nd line chemotherapy. Type of chemotherapy is determined by treating oncologist
Study: NCT06675058

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Indirect Pulp Treatment
Description: Indirect pulp treatment is considered one of the most conservative pulp therapies, which preserves the pulp's vitality in teeth with reversible pulpitis. It has been chosen to be the intervention in both groups as the aim of this study is to assess the impact of caries location (proximal vs. occlusal caries) in influencing the success rate of IPT.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Indirect Pulp Treatment
Description: Indirect pulp treatment is considered one of the most conservative pulp therapies, which preserves the pulp's vitality in teeth with reversible pulpitis. It has been chosen to be the intervention in both groups as the aim of this study is to assess the impact of caries location (proximal vs. occlusal caries) in influencing the success rate of IPT.
Study: NCT06675396

Intervention type: OTHER
Intervention: Antidepressants
Description: control
Study: NCT06675734

Intervention type: DRUG
Intervention: diclofenac sodium solution
Description: The experimental group consisted of patients in whom diclofenac sodium was administered IM and the control group consisted of patients in whom diclofenac sodium was administered orally only.
Study: NCT06370208

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic Bactoblis® EVOL (Streptococcus salivarius eK12)
Description: Bactoblis® EVOL: containing one billion CFU of probiotic Streptococcus salivarius eK12
Study: NCT06675591

Intervention type: OTHER
Intervention: Rapid sodium correction
Description: This study focuses on the exposure to different sodium correction rates in patients with severe hyponatremia (serum sodium ≤ 120 mEq/L) rather than an active intervention. The two key groups are defined by their rate of sodium correction during the first 24 hours of hospitalization:~Rapid Sodium Correction: An increase in serum sodium of ≥ 8 mEq/L within 24 hours.~Slow Sodium Correction: An increase in serum sodium of \&lt; 8 mEq/L within 24 hours.~The primary objective is to assess the association between these exposure rates and clinical outcomes, including in-hospital mortality, 30-day mortality, and the incidence of osmotic demyelination syndrome (ODS). This study differs from others by using a large, retrospective cohort of patients treated in a real-world clinical setting, spanning 13 years (2010-2023), and applying robust statistical adjustments such as propensity score analysis to control for confounders.

Intervention type: OTHER
Intervention: Slow sodium correction
Description: This study focuses on the exposure to different sodium correction rates in patients with severe hyponatremia (serum sodium ≤ 120 mEq/L) rather than an active intervention. The two key groups are defined by their rate of sodium correction during the first 24 hours of hospitalization:~Rapid Sodium Correction: An increase in serum sodium of ≥ 8 mEq/L within 24 hours.~Slow Sodium Correction: An increase in serum sodium of \&lt; 8 mEq/L within 24 hours.~The primary objective is to assess the association between these exposure rates and clinical outcomes, including in-hospital mortality, 30-day mortality, and the incidence of osmotic demyelination syndrome (ODS). This study differs from others by using a large, retrospective cohort of patients treated in a real-world clinical setting, spanning 13 years (2010-2023), and applying robust statistical adjustments such as propensity score analysis to control for confounders.
Study: NCT06587659

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulation
Description: The MagPro R30 is an advanced, high performance magnetic stimulator designed primarily for non-invasive clinical use. The non-invasive brain stimulation system will be used to deliver active repetitive electromagnetic pulses in this research study's treatment of post-traumatic stress disorder.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Robotic Arm
Description: This robotic system is based on a commercially available collaborative robot. The robot is mounted on a cart which holds the robot controller and the TMS power supply and pulse-generation computer. The robotic system will be used for TMS coil positioning/targeting.
Study: NCT06686641

Intervention type: DRUG
Intervention: Local and systemical treatment
Description: Evaluating the management of the edema including topical/local treatment (dexamethasone and NSAID, periocular injections, and dexamethasone intravitreal implant) and systemic treatment (prednisolone, DMARD, and biological agents, for example TNF-alpha inhibitors and interleukin-6 inhibitors). Moreover, the duration of any treatment as well as numbers of injections or implants.
Study: NCT04983602

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Comprehensive Geriatric Assessment arm
Description: The intervention will involve a comprehensive geriatric assessment which will be provided by a geriatric doctor, physiotherapist, occupational therapist, social worker, pharmacist and specialist nurse.,

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: EDPLUS
Description: EDPLUS involves a 6 week physiotherapy led community based intervention involving 3 home visits and weekly telephone support.
Study: NCT06630416

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood and urine sample collection
Study: NCT06419920

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Flat terrain locomotor training
Description: The training will be comprised of up to 12 sets of 2-min continuous walking on a level treadmill or mat, interspersed with rest breaks of at least one minute. Training will be completed three times per week for four weeks.
Study: NCT05512338

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treatment
Description: ACT-informed interventions combined with standard physiotherapy methods.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Active control group
Description: Standard physiotherapy methods.
Study: NCT05902442

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: 3DxSPLINT
Description: Routine immobilization procedure with a patient-specific 3D printed splint instead of the use of a conventional forearm splint after one week of conventional immobilization.
Study: NCT06027398

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: SARS-CoV-2 RNA detection
Description: SARS-CoV-2 RNA detection in used mask filters
Study: NCT05998759

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Telitacicept
Description: subcutaneous telitacicept 160 mg weekly for 24 weeks.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: subcutaneous placebo weekly for 24 weeks.