Study: NCT05200845

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose
Description: Participants will consume flavored beverage solutions containing 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose
Description: Participants will consume flavored beverage solutions containing 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose
Description: Participants will consume flavored beverage solutions containing 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus + (CS+): Flavored beverage solution with 75 calories of sucrose
Description: Participants will consume flavored beverage solutions containing 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose
Description: Participants will consume flavored beverage solutions sweetened with sucralose to match the sweetness of 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose
Description: Participants will consume flavored beverage solutions sweetened with sucralose to match the sweetness of 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose
Description: Participants will consume flavored beverage solutions sweetened with sucralose to match the sweetness of 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditioned Stimulus - (CS-): Flavored beverage solution with sweetness-matched sucralose
Description: Participants will consume flavored beverage solutions sweetened with sucralose to match the sweetness of 75 calories of sucrose in 6 exposure sessions within 1 week. One exposure session will include pre- and post-consumption blood draws over a 2-hour period, and one exposure session will include indirect calorimetry measurement pre- and post-consumption. The other 4 exposure sessions will occur at specified times outside the laboratory sessions. Subjective ratings of internal state (i.e., hunger, fullness, and thirst) will be collected throughout each exposure. Subjective ratings of liking and wanting of each beverage will also be assessed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Fat Test Meal Inside a Metabolic Chamber
Description: A high-fat test meal (60% fat, 20% carbohydrate) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Fat Test Meal Inside a Metabolic Chamber
Description: A high-fat test meal (60% fat, 20% carbohydrate) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Fat Test Meal Inside a Metabolic Chamber
Description: A high-fat test meal (60% fat, 20% carbohydrate) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Fat Test Meal Inside a Metabolic Chamber
Description: A high-fat test meal (60% fat, 20% carbohydrate) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Carbohydrate Test Meal Inside a Metabolic Chamber
Description: A high-carbohydrate test meal (60% carbohydrate, 20% fat) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Carbohydrate Test Meal Inside a Metabolic Chamber
Description: A high-carbohydrate test meal (60% carbohydrate, 20% fat) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Carbohydrate Test Meal Inside a Metabolic Chamber
Description: A high-carbohydrate test meal (60% carbohydrate, 20% fat) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Carbohydrate Test Meal Inside a Metabolic Chamber
Description: A high-carbohydrate test meal (60% carbohydrate, 20% fat) will be provided after a 1-hour baseline measurement of substrate oxidation during a 6-hour metabolic chamber stay. Postprandial substrate oxidation will be measured for 5 hours.