TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05638464

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: multisite HD-tDCS EMG-driven robot hand
Description: Multisite HD-tDCS will individual stimulation montages with robot hand training will be applied on chronic stroke survivors. In the multisite HD-tDCS group, 5-8 sintered Ag/AgCl ring electrodes will be placed based on the neuroimaging and computation modelling. The location of the electrodes will be identified by the individual brain activity in the primary motor cortex derived from tasked-based fMRI. The Finite Element Model (FEM) will be used to simulate the electric field distribution on individual brain. Optimization of stimulation montages will be based on the derived activation pattern of the brain. After 20-minute multisite HD-tDCS, EMG-driven robot hand training will be conducted.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham HD-tDCS EMG-driven robot hand
Description: Sham stimulation with robot hand training will be applied on chronic stroke survivors.~After the sham stimulation, EMG-driven robot hand training will be conducted.
Study: NCT05441488

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: treatment per os

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Masitinib (4.5)
Description: Masitinib (titration to 4.5 mg/kg/day)
Study: NCT05951803

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Brief Behavioral Intervention in Insomnia
Description: Weekly intervention of 4 sessions where behavior therapy techniques are administered, such as stimulus control, sleep hygiene, sleep restriction and progressive muscle relaxation. Each session lasts 60 minutes.
Study: NCT06527846

Intervention type: DRUG
Intervention: JARDIANCE®
Description: JARDIANCE®
Study: NCT06398561

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Active Patient Program
Description: The Active Patient Program is a peer-leader intervention that consist of training patients with a chronic disease or mental health illness for improve the symptoms of that pathology.~Training is carried out in groups of about 12-15 patients and usually has 2 patient trainers. These patients lead the sessions through the theoretical content they have integrated, motivation, group leadership, exchange of experiences and promotion of communication. In this way they favor problem-solving by the patients who attend the sessions, thus improving their self-management and self-efficacy.~In the group formed by patients who are trainers and patients who benefit from the sessions, a climate of trust is created that favors the expression of emotions on both sides, empathy and assertiveness. In addition to fostering socio-affective bonds between the participants and increasing perceived social and emotional support.
Study: NCT05085015

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Functional Exercise Training Group
Description: Training will start with Stretching Training and end with stretching training. Stretching exercises targeting actively applied shoulder girdle, chest, neck, trunk, hip, front and back leg and ankle muscle groups will be given. Afterwards, it will be continued with Aerobic Exercise Training. The training will be given on the treadmill Treadmill Technogym. Afterwards, it will be continued with Strengthening Training. Strength training will consist of a strengthening program that includes the lower extremity, upper extremity, trunk and core region. Elastic bands will be used in the training. Then, balance training will be given at the end.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home Exercise Training Group
Description: Training will start with Stretching Training and end with stretching training. Stretching exercises targeting actively applied shoulder girdle, chest, neck, trunk, hip, front and back leg and ankle muscle groups will be given. Afterwards, it will be continued with Aerobic Exercise Training. They will walk at least 30 minutes, 3 days a week for 8 weeks at outdoor. Afterwards, it will be continued with Strengthening Training. Strength training will consist of a strengthening program that includes the lower extremity, upper extremity, trunk and core region. Elastic bands will be used in the training. Then, balance training will be given at the end.
Study: NCT06398561

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Active Patient Program
Description: The Active Patient Program is a peer-leader intervention that consist of training patients with a chronic disease or mental health illness for improve the symptoms of that pathology.~Training is carried out in groups of about 12-15 patients and usually has 2 patient trainers. These patients lead the sessions through the theoretical content they have integrated, motivation, group leadership, exchange of experiences and promotion of communication. In this way they favor problem-solving by the patients who attend the sessions, thus improving their self-management and self-efficacy.~In the group formed by patients who are trainers and patients who benefit from the sessions, a climate of trust is created that favors the expression of emotions on both sides, empathy and assertiveness. In addition to fostering socio-affective bonds between the participants and increasing perceived social and emotional support.
Study: NCT06127316

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Carbon Fiber Custom Dynamic Orthosis (CDO)
Description: The carbon fiber custom dynamic orthoses (CDOs) used in this study will consist of a semi-rigid carbon fiber footplate, a carbon fiber posterior strut, and a proximal cuff that wraps around the leg below the knee. The CDO will be modular in design which will allow three carbon fiber struts of the same stiffness and differing lengths to be used to implement 0cm, 1cm, and 2cm levels of heel distraction height. A longer posterior strut will move the carbon fiber footplate away from the participants foot to create the heel distraction height.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Carbon Fiber Custom Dynamic Orthosis (CDO)
Description: The carbon fiber custom dynamic orthoses (CDOs) used in this study will consist of a semi-rigid carbon fiber footplate, a carbon fiber posterior strut, and a proximal cuff that wraps around the leg below the knee. The CDO will be modular in design which will allow three carbon fiber struts of the same stiffness and differing lengths to be used to implement 0cm, 1cm, and 2cm levels of heel distraction height. A longer posterior strut will move the carbon fiber footplate away from the participants foot to create the heel distraction height.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Carbon Fiber Custom Dynamic Orthosis (CDO)
Description: The carbon fiber custom dynamic orthoses (CDOs) used in this study will consist of a semi-rigid carbon fiber footplate, a carbon fiber posterior strut, and a proximal cuff that wraps around the leg below the knee. The CDO will be modular in design which will allow three carbon fiber struts of the same stiffness and differing lengths to be used to implement 0cm, 1cm, and 2cm levels of heel distraction height. A longer posterior strut will move the carbon fiber footplate away from the participants foot to create the heel distraction height.
Study: NCT05558605

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: AI-guided echo
Description: AI-guided echocardiography

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Standard echo
Description: Standard echocardiography
Study: NCT06567275

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: block
Description: ultrasound guided nerve block

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: block
Description: ultrasound guided nerve block
Study: NCT06568328

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Chimeric Natural Killer Receptor Universal T-cells (CNK-UT)
Description: OUTLINE: This is a dose-escalation study of CNK-UT cells followed by a dose-expansion study.~1. Dose Escalation (Single Ascending Dose Study, SAD): During SAD study stage, the participants will be intravenous infused with CNK-UT cells (1\~10×10\^7 CNK+ cells/kg)with a3 +3 design to determine the maximum tolerated dose. During single ascending dose (SAD) study stage, the participants will receive a single dose of CNK-UT cells before the DLT observation period (21 days). If the participants do not experience DLT, they will be able to enter a multiple ascending dose (MAD) study stage.~2. Dose Expansion (multiple ascending dose study, MAD): During MAD study stage, the participants will receive multiple doses of CNK-UT cells. The dosage and frequency of drug administration in the dose expansion stage can be adjusted and determined according to the SAD study.
Study: NCT05674721

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Advil PM Liqui-Gels Minis
Description: Ibuprofen/diphenhydramine hydrochloride 200 mg/25 mg, Oral capsule which is a size reduction of the currently marketed reference product.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Advil PM Liqui-Gels
Description: Ibuprofen/diphenhydramine hydrochloride 200 mg/25 mg, Oral capsule.
Study: NCT06079801

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial direct current stimulation (tDCS)
Description: TDCS was delivered by a DC-Stimulator (Newronika, Italy) over both DLPC. The electrodes (35 cm2) were soaked in 0.9% NaCl. The anode was positioned on the left dorsolateral prefrontal cortex and the cathode on the right dorsolateral prefrontal cortex.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Transcranial direct current stimulation (tDCS)
Description: TDCS was delivered by a DC-Stimulator (Newronika, Italy) over both DLPC. The electrodes (35 cm2) were soaked in 0.9% NaCl. The anode was positioned on the left dorsolateral prefrontal cortex and the cathode on the right dorsolateral prefrontal cortex.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: anti-CGRP-mAbs
Description: CGRP-mAbs have been the first target-driven treatment to be approved for migraine prevention. Their efficacy and safety have been demonstrated in randomized controlled trials (RCT) as well as, in real-world evidence (RWE) studies
Study: NCT05513482

Intervention type: DIAGNOSTIC_TEST
Intervention: Tissue Doppler Imaging
Description: With tissue Doppler ultrasonography (TDI), the maximum contraction rate of the diaphragm, maximum relaxation rate, and integral against time will be examined.

Intervention type: DIAGNOSTIC_TEST
Intervention: M Mode Imaging
Description: Diaphragm displacement during inspiration and expiration will be measured with M mode imaging
Study: NCT00357981

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ORTHO EVRA, the contraceptive patch
Study: NCT06286501

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Lumoral Treatment
Description: Home-use photodynamic antibacterial dual-light oral health care device with a marker substance

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard, personalized oral health care
Description: Home-based oral health care instructed by a professional, with emphasis on personal needs according to oral condition and previous oral health care habits.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard, personalized oral health care
Description: Home-based oral health care instructed by a professional, with emphasis on personal needs according to oral condition and previous oral health care habits.
Study: NCT06118801

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic Product Supplement
Description: Mothers of preterm babies who feed their babies only with breast milk will be given a probiotic product supplement once a day (80 ml probiotic product support containing the Actregularis (5×106 CFU\\mL) (lactobacillus bulgaricus, streptococcus thermophilus, lactococcus lactis and bifidobacterium lactis) strain)
Study: NCT06254716

Intervention type: PROCEDURE
Intervention: disc resection
Description: disc resection refers to the full-thickness resection of the lesion and the intestinal wall, usually anterior rectal wall. During the operation, the anterior intestinal wall is opened and then sutured or anastomosed with a stapler. Segmental bowel resection for the treatment of intestinal endometriosis was first reported by Redwine and Sharpe in 1991, which requires the maximum removal of endometriosis lesions.

Intervention type: PROCEDURE
Intervention: segmental resection
Description: Segmental bowel resection for the treatment of intestinal endometriosis was first reported by Redwine and Sharpe in 1991, which requires the maximum removal of endometriosis lesions.
Study: NCT05421819

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Calcium and vitamin D supplement
Description: One hundred fifty postmenopausal women with osteopenia will be randomly and blindly allocated to receive in of the 3 different dietary supplements once per day. Patients of group A will receive orally 600 mg calcium and 2400 IU vitamin D3, group B will receive the same dose of calcium and vitamin D3 plus prebiotics once per day and group C will receive the same dose of calcium, vitamin D3 plus flavonoids once per day.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Calcium, vitamin D and prebiotic supplement
Description: One hundred fifty postmenopausal women with osteopenia will be randomly and blindly allocated to receive in of the 3 different dietary supplements once per day. Patients of group A will receive orally 600 mg calcium and 2400 IU vitamin D3, group B will receive the same dose of calcium and vitamin D3 plus prebiotics once per day and group C will receive the same dose of calcium, vitamin D3 and flavonoids once per day.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Calcium, vitamin D and flavonoid supplement
Description: One hundred fifty postmenopausal women with osteopenia will be randomly and blindly allocated to receive in of the 3 different dietary supplements once per day. Patients of group A will receive orally 600 mg calcium and 2400 IU vitamin D3, group B will receive the same dose of calcium and vitamin D3 plus prebiotics once per day and group C will receive the same dose of calcium, vitamin D3 and flavonoids once per day.
Study: NCT05786560

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: BABE (Body Appreciation and Better Eating)
Description: The participants will be randomized into either a treatment or control group. For the treatment arm, girls will participate in the Body Project for 30 minutes, then will be given a 30-minute self-compassion-based nutrition education lesson. Nutrition topics will cover the basic biochemistry of nutrition, nutrition needs for teenage girls, and ways to find balance in eating, framed in the constructs of self-compassion. The control group will receive the same 30-minute Body Project class and the same 30-minute nutrition education class; however, there will be no incorporation of self-compassion.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: BABE (Body Appreciation and Better Eating)
Description: The participants will be randomized into either a treatment or control group. For the treatment arm, girls will participate in the Body Project for 30 minutes, then will be given a 30-minute self-compassion-based nutrition education lesson. Nutrition topics will cover the basic biochemistry of nutrition, nutrition needs for teenage girls, and ways to find balance in eating, framed in the constructs of self-compassion. The control group will receive the same 30-minute Body Project class and the same 30-minute nutrition education class; however, there will be no incorporation of self-compassion.
Study: NCT06233058

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Drospirenone+ Ethinyl Estradiol Tablets-Test product
Description: Drospirenone (3 mg) + Ethinyl Estradiol (0.03 mg) Tablets Manufactured by: Umeda Company Limited, Thailand

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Drospirenone+ Ethinyl Estradiol Tablets-Reference product
Description: Drospirenone (3 mg) + Ethinyl Estradiol (0.03 mg) Tablets Manufactured by: Bayer AG, Berlin, Germany
Study: NCT04289467

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fenfluramine
Description: Open-label
Study: NCT05776732

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 3M CaviionTM
Description: 3M CaviionTM is mainly composed of acrylate trimer, non-toxic, alcohol-free, and compatible with chlorhexidine gluconate and povidone iodine.
Study: NCT06542705

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Arthrex Internal Brace
Description: The Arthrex Internal Brace method for ACL reconstruction consists of suture tape used to reinforce the ACL during surgery. This suture tape is secured in place with bioabsorbable anchors that gradually degrade within the body over time.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: ACL Reconstruction
Description: All patients will undergo ACL reconstruction (ACLR) with or without an internal brace. ACLR technique will be standardized to standard anteromedial (AM) portal femoral drilling to ensure consistency between surgeons.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: ACL Reconstruction
Description: All patients will undergo ACL reconstruction (ACLR) with or without an internal brace. ACLR technique will be standardized to standard anteromedial (AM) portal femoral drilling to ensure consistency between surgeons.
Study: NCT06541483

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ultra-Fast-Track Cardiac Anesthesia(UFTCA)
Description: (UFTCA)The researcher removed the endotracheal tube either immediately or within 1 hour of the end of the procedure.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: conventional general anesthesia (CGA)
Description: (CGA)The researcher not extubated at the end of the operation and were admitted to the ICU under anesthesia with an endotracheal tube.
Study: NCT04691739

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: occupational therapy
Description: occupational therapy sessions include a set of standardized test exercises plus additional modalities that are optimized to each patient's needs according to the clinical judgement of the treating therapist

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: occupational therapy
Description: occupational therapy sessions include a set of standardized test exercises plus additional modalities that are optimized to each patient's needs according to the clinical judgement of the treating therapist
Study: NCT05614466

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: The Simply B Study
Description: This study will be conducted in three parts:~Part A: A prospective open label pilot intervention study, comparing the proportion of people with hepatitis B who are managed by their GP in primary care clinics before, 12 months and 24 months after implementation of the Simply B electronic hepatitis B support package.~Part B: A nested qualitative health services feasibility study using semi -structured interviews and thematic analysis Part C: A mathematical modelling study using a Markov model to determine cost effectiveness of Simply B for increasing hepatitis B treatment uptake compared to status quo of hospital care.
Study: NCT04832178

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: SUMOR
Description: SUMOR is a food supplement distributed in Italy by ArcaPharma. regularly entered in the register of Food Supplements of the Ministry of Health (number 62590). Formulated in prolonged-release tablets, each tablet contains the following substances:~* S-Adenosyl-L-Methionine sulfate p-toluenesulfonate 250 mg~* Betaine hydrochloride 250 mg~* Vitamin C 80 mg~* Vitamin B1 1.1 mg~* Vitamin B2 1.4 mg~* Vitamin B6 1.4 mg~* Vitamin B12 2,5 µg~* Folic Acid 200 µg~* Selenium 37 µg

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablet will be identical in appearance to the experimental product (SUMOR).
Study: NCT05648968

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ianalumab
Description: i.v. infusion, prepared from concentrate solution

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ianalumab
Description: i.v. infusion, prepared from concentrate solution

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: i.v. infusion, prepared from matching placebo
Study: NCT05317039

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: silica-calcium phosphate nanocomposite SCPC
Description: Patients will be treated with the buccal plate repositioning technique and grafted with SCPC then the grafted defect will be covered with a platelet-rich fibrin membrane.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: freezed dried bone
Description: Patients will be treated with the buccal plate repositioning technique and grafted using DFDBA. then the grafted defect will be covered with a platelet-rich fibrin membrane.
Study: NCT06645691

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hyperpolarized 13C-pyruvate
Description: Hyperpolarized 13C-pyruvate is injected intravenously at a dose of 0.43 mL/kg body weight, and at a rate of 5 mL/second followed by a 20 mL saline flush at 5 mL/second when the patient is already in the MRI scanner
Study: NCT04818918

Intervention type: DEVICE
Intervention: Absolute coronary flow measurement
Description: Absolute coronary flow will be measured.

Intervention type: DEVICE
Intervention: Absolute coronary flow measurement
Description: Absolute coronary flow will be measured.

Intervention type: DEVICE
Intervention: Microvascular resistance measurement
Description: Microvascular resistance will be measured.

Intervention type: DEVICE
Intervention: Microvascular resistance measurement
Description: Microvascular resistance will be measured.

Intervention type: OTHER
Intervention: Cardiac MRI
Description: Cardiac MRI will be performed to evaluate myocardial viability.
Study: NCT05148247

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Perceive, Recall, Plan and Perform System of Intervention
Description: The aim of the PRPP intervention is to enhance mastery in performance of needed or desired occupations, and extend traditional task training. Systematic instructions to support the clients' cognitive capacity to think about doing in different tasks and contexts are given by the OT, based on the results of PRPP Assessment stage 2. Further, the OT uses graded verbal, visual or physical prompts and cues directly during the participants task performance, progressing from content-free meta-prompts 'Stop' to alert the participant to process information required for the task, and for errorless learning. Then the OT prompt 'sense/attend, think and do', to more specific behavioural prompts selected by the therapist based on the components from the PRPP Assessment stage 2. At best the skills are generalized throughout all everyday activities, and the OTs' role as a cognitive mediator fades as the person internalize the strategies.
Study: NCT05844644

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Release
Description: One capsule of Release will be taken three times per day for 180 days in combination with the G4LP.
Study: NCT03651895

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Metformin
Description: Drug

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo