TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04526418

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: 24/7 EEG™ SubQ system
Description: Electrographic seizure recording sensitivity of an ipsilaterally implanted 24/7 EEG™ SubQ system: proportion of identified ipsilateral seizures as compared to ipsilateral video-EEG during admission to the Epilepsy Monitoring Unit
Study: NCT05832307

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Existing Influenza Vaccination Practices
Description: Usual care is defined as the existing inpatient influenza vaccination practices that currently exist at a given site.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standardized inpatient influenza vaccination program
Description: Intervention A: The basic intervention is the inpatient influenza vaccination program Intervention B: The intensified intervention is the multifaceted influenza vaccination strategy (Intervention A) plus a learning collaborative
Study: NCT05853575

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adagrasib
Description: KRAS G12C inhibitor

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adagrasib
Description: KRAS G12C inhibitor
Study: NCT04690582

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Processing Therapy (CPT)
Description: Cognitive processing therapy (CPT) is a specific type of cognitive behavioral therapy that has been effective in reducing symptoms of PTSD that have developed after experiencing a variety of traumatic events including child abuse, combat, rape and natural disasters. CPT is generally delivered over 12 sessions and helps patients learn how to challenge and modify unhelpful beliefs related to the trauma. In so doing, the patient creates a new understanding and conceptualization of the traumatic event so that it reduces its ongoing negative effects on current life. This treatment is strongly recommended for the treatment of PTSD.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Processing Therapy (CPT)
Description: Cognitive processing therapy (CPT) is a specific type of cognitive behavioral therapy that has been effective in reducing symptoms of PTSD that have developed after experiencing a variety of traumatic events including child abuse, combat, rape and natural disasters. CPT is generally delivered over 12 sessions and helps patients learn how to challenge and modify unhelpful beliefs related to the trauma. In so doing, the patient creates a new understanding and conceptualization of the traumatic event so that it reduces its ongoing negative effects on current life. This treatment is strongly recommended for the treatment of PTSD.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Crisis Response Plan (CRP)
Description: The crisis response plan (CRP) is a collaborative, patient-centered intervention that is typically handwritten on an index cards and focuses on several key components: (1) warning signs, (2) self-regulatory strategies, (3) reasons for living, (4) sources of social support, and (5) professional and crisis services.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Safety Planning Intervention (SPI)
Description: The safety planning intervention (SPI) is a suicide-focused intervention typically handwritten on a pre-printed form that includes the following sections: (1) warning signs, (2) internal coping strategies, (3) people and social settings that provide distraction, (4) people who can offer help, (5) professionals or agencies they can contact during a crisis, and (6) making the environment safe.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Narrative Assessment
Description: The narrative assessment is a patient-centered assessment approach in which the clinician invites the patient to share the story of a recent crisis or period of intense emotional distress. Patients are asked to identify the thoughts, emotions, and physical sensations experienced in the time leading up to this crisis, as well as the contextual and environmental characteristics surrounding the crisis. Information obtained from the narrative assessment is then used to help formulate a crisis response plan.
Study: NCT04352231

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: High Fiber Diet Intervention
Description: Plant-based diet with a targeted quantity of 35 g of dietary fiber per day, from a variety of fiber types. Each meal will be balanced to provide all essential nutrients and portions will be of adequate size to ensure participants are satiated. Participants on both diet interventions will be given multivitamin supplements in order to ensure they are receiving essential vitamins and minerals.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: High Fiber Diet Intervention
Description: Plant-based diet with a targeted quantity of 35 g of dietary fiber per day, from a variety of fiber types. Each meal will be balanced to provide all essential nutrients and portions will be of adequate size to ensure participants are satiated. Participants on both diet interventions will be given multivitamin supplements in order to ensure they are receiving essential vitamins and minerals.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Low Fiber Diet Intervention
Description: Animal based diet (meat, dairy) with a targeted quantity of 10 g of dietary fiber per day. Each meal will be balanced to provide all essential nutrients and portions will be of adequate size to ensure participants are satiated. Participants on both diet interventions will be given multivitamin supplements in order to ensure they are receiving essential vitamins and minerals.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Low Fiber Diet Intervention
Description: Animal based diet (meat, dairy) with a targeted quantity of 10 g of dietary fiber per day. Each meal will be balanced to provide all essential nutrients and portions will be of adequate size to ensure participants are satiated. Participants on both diet interventions will be given multivitamin supplements in order to ensure they are receiving essential vitamins and minerals.
Study: NCT05880784

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Reinforcement of Peer coaching and clinical audit
Description: The goal of the proposed research study is to test the effectiveness and feasibility of an intervention to enhance peer coaching and clinic audit activities to facilitate the implementation of the Package of Essential Non- Communicable Diseases (PEN) in Nepal.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Continuation of usual practice without intervention
Description: No intervention will be carried out, instead usual practice will be evaluated at the start and the end of the study period.
Study: NCT05468151

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cold acclimation
Description: The cold water immersions will last 30-60 minutes per day and the volunteers will undergo 2-3 cold immersions per week.

Intervention type: OTHER
Group type: OTHER
Intervention: Intervention Control group - volunteers with obesity
Description: Participants with obesity in the control group will undergo PET/CT scans at baseline and 12 weeks after the first scan.

Intervention type: OTHER
Group type: OTHER
Intervention: Acute cold exposure
Description: All participants (lean and with obesity) will undergo PET/scans after 2 hours of cold exposure to investigate BAT perfusion and BAT glucose uptake.
Study: NCT05053230

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: IM@Home
Description: Participants in the IM@Home group will receive a 12-week virtual, synchronous, mind-body and fitness program. The Classes will be conducted via Zoom video conferencing platform. Patients will choose from a variety of weekly classes, occurring one to four times per week. An Integrative Medicine Service (IMS) clinical therapist (e.g., licensed dance therapist, certified yoga instructor, nurse specialist/physical trainer) with specific expertise in the oncology setting will lead each session. Activities range from more movement-based (fitness, yoga, dance therapy, or tai chi) to meditative-based classes (meditation, guided meditation, or music therapy). All clinicians will provide an overview of the session, 25 to 40 minutes of content, and five minutes for feedback and discussion. Each class lasts 30 to 45 minutes with optional audio or video participant participation and group chat.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Enhanced usual care
Description: Patients in the enhanced usual care will receive usual care. In addition, once enrolling into the trial, they will be given a handout to encourage them to visit the MSK's multimedia page on the Integrative Medicine website to access pre-recorded, on-demand meditation audio or video recordings for meditation, guided imagery, and relaxation.
Study: NCT06274801

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Seralutinib
Description: Capsule containing seralutinib

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Gereic Dry Powder Inhaler
Description: Generic dry powder inhaler for seralutinib delivery
Study: NCT05732623

Intervention type: BEHAVIORAL
Intervention: Semi Quantitative Food Frequency Questionnaire (SQFFQ)
Description: The SQFFQ quantifies the frequency of consumption of each food and drink and the following list of variables:~* date of birth~* sex~* ethnicity~* weight (kg)~* height (m)~* BMI (kg/m2) at the time of eoCRC diagnosis and at 18 years old~* country where they live permanently~* tobacco smoking at the time of eoCRC diagnosis and at 18 years old~* sitting time~* TV-viewing time~* moderate-to-vigorous physical activity (MVPA)~* waist circumference (cm)~* home blood pressure levels (mmHg)~* fasting blood glucose (mg/dl)~* regular consumption of aspirin/NSAID and years of consumptions~* calcium and folate supplements and years of consumptions~* oral contraceptive agents and years of consumptions~* post-menopausal hormones and years of consumptions

Intervention type: BEHAVIORAL
Intervention: Semi Quantitative Food Frequency Questionnaire (SQFFQ)
Description: The SQFFQ quantifies the frequency of consumption of each food and drink and the following list of variables:~* date of birth~* sex~* ethnicity~* weight (kg)~* height (m)~* BMI (kg/m2) at the time of eoCRC diagnosis and at 18 years old~* country where they live permanently~* tobacco smoking at the time of eoCRC diagnosis and at 18 years old~* sitting time~* TV-viewing time~* moderate-to-vigorous physical activity (MVPA)~* waist circumference (cm)~* home blood pressure levels (mmHg)~* fasting blood glucose (mg/dl)~* regular consumption of aspirin/NSAID and years of consumptions~* calcium and folate supplements and years of consumptions~* oral contraceptive agents and years of consumptions~* post-menopausal hormones and years of consumptions
Study: NCT06547216

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AOC 1020
Description: AOC 1020 will be administered via intravenous (IV) infusion
Study: NCT06046014

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: BI Focused writing
Description: BI Focused writing program

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Attention Control Writing
Study: NCT05514470

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Skin biopsy
Description: A skin biopsy performed on the forearm or thigh depending on the patient's age and wishes, with a biopsy punch with a diameter of 3 to 4 mm depending on the child's age (3 for children under 3 years, 4 beyond).~Culture of fibroblasts and immortalization.
Study: NCT05899764

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Brivaracetam
Description: * Intravenous administration: 25 mg or 50 mg will be administered depending on its effects on epileptic activity during a hospital stay where simultaneous EEG and depth electrode recordings will be measuring epileptic activity.~* Oral administration: Subjects will take 25mg or 50mg twice a day for 12 months. The dosage will depend on its effects on epileptic activity. Brivaracetam levels will be measured on months 3, 6 and 12.
Study: NCT05039424

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Endoscopic per-oral pyloromyotomy (POP)
Description: Per-oral pyloromyotomy (POP), alternatively knows as gastric per-oral endoscopic myotomy (G-POEM), accomplishes longitudinal division of the pylorus using an endoscope. This procedure involves utilizing endoscopic electrosurgical knife to make an incision in the gastric mucosa and develop a submucosal tunnel to visualize the pyloric ring. The pyloric ring is divided longitudinally, and the mucosotomy incision is sealed with endoscopic clips.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Endoscopic per-oral pyloromyotomy (POP)
Description: Per-oral pyloromyotomy (POP), alternatively knows as gastric per-oral endoscopic myotomy (G-POEM), accomplishes longitudinal division of the pylorus using an endoscope. This procedure involves utilizing endoscopic electrosurgical knife to make an incision in the gastric mucosa and develop a submucosal tunnel to visualize the pyloric ring. The pyloric ring is divided longitudinally, and the mucosotomy incision is sealed with endoscopic clips.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Diagnostic esophagogastroduodenoscopy (EGD) without pyloric disruption
Description: While under general anesthesia, a standard gastroscope is introduced and a diagnostic upper endoscopy is performed. The operator talks through the procedure steps as if completing POP. The gastroscope is withdrawn and the patient is extubated.
Study: NCT05550337

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trifarotene 0.005 % Topical Cream
Description: Cream

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: AKLIEF®
Description: Cream

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Cream
Study: NCT06036524

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Multi-modal, multi-parametric, multiscale imaging of the myofascial unit
Description: Study Participants will undergo four study procedures at one visit, including magnetic resonance imaging (MRI), surface electromyography (sEMG), fiber-optic imaging and sensing, and questionnaires.
Study: NCT06640582

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Tumor Infiltrating Lymphocytes (TIL)
Description: Tumor Infiltrating Lymphocytes (TIL) IV
Study: NCT05455658

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD105/Yb-1/SOX2/CDH3/MDM2-polyepitope Plasmid DNA Vaccine
Description: Given IV

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Sargramostim
Description: Given ID
Study: NCT05694507

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mental Well-being Chatbot
Description: The chatbot contents are developed by Clinical psychologists and well-being promotion officers. Content includes relationships, stress, value, emotion, and positive psychology.
Study: NCT04774185

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: New hearing aid loudspeaker
Description: The new hearing aid loudspeaker will be fitted to the participants individual ear anatomy and hearing loss.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Standard hearing aid loudspeaker
Description: The standard hearing aid loudspeaker will be fitted to the participants individual ear anatomy and hearing loss.
Study: NCT05347537

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mulligan mobilization
Description: Mulligan Mobilization designed to reduce pain and improve the patient's range of motion. Mulligan's mobilization with movement at the frequency of 3 sets with 10 repetitions 3 times/ week without the clamshell exercise.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: clamshell exercise
Description: As a general exercise, the clamshell can help strengthen your medial glutes, bringing more power and stability to your hips. This group treated with mulligan's mobilization with movement and clamshell exercises.
Study: NCT06640582

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamide will be administered as an intravenous (IV) infusion for two days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Fludarabine will be administered as an intravenous (IV) infusion for five days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Interleukin-2
Description: After TIL infusion, IL-2 will be started as a bolus administration every eight hours, for a maximum of eight doses.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Intravenous (IV) infusion
Study: NCT06642961

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GR1802 injection
Description: GR1802 will be administered SC.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GR1802 injection
Description: GR1802 will be administered SC.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: The placebo will be administered SC.
Study: NCT06563674

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acceptance-based healthy lifestyles program (intervention group)
Description: The acceptance-based healthy lifestyles program consists of 4 biweekly 60-min face-to-face interactive workshops to cover the knowledge of pneumoconiosis, exercise to maintain lung function, health diet, and home safety.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Acceptance-based healthy lifestyles program (control group)
Description: The acceptance-based healthy lifestyles program consists of 4 biweekly 60-min face-to-face interactive workshops to cover the knowledge of pneumoconiosis, exercise to maintain lung function, health diet, and home safety.
Study: NCT06636838

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Spanish-Speaking Provider
Description: Spanish speaking patients will be seen by our Spanish-speaking provider
Study: NCT06639737

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: preoperative stroke volume optimization
Description: Stroke volume optimization using transthoracic echocardigraphy (sub aortic velocity time integral) before induction of total intravenous anesthesia. Fluids bolus of 250 ml of cristalloids will be successively administered until the sub aortic velocity time integral increase will be \< 10%

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Post induction stroke volume optimization
Description: Optimization of stroke volume following induction of general anesthesia using oesophageal stroke volume measurement. 250 ml bolus of cristalloids succesively administered until the stroke volume increase \<10%
Study: NCT04702607

Intervention type: PROCEDURE
Intervention: contrast enhanced 4DCT
Description: Functional Lung Imaging with DECT and 4DCT
Study: NCT05692323

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PREHAB
Description: 6-week supervised PREHAB program. Each week of the program consists of 3 x 1 hour supervised training sessions made up of moderate intensity aerobic training and resistance training. In addition to the supervised sessions, patients will be instructed to accumulate a total of 150 minutes per week of moderate aerobic training at home which is measured by a wrist worn FitBit device.
Study: NCT06168968

Intervention type: BEHAVIORAL
Intervention: Life and Medication Recommendations
Description: Based on obtained subjective and objective data from patient-filled questionnaire and laboratory testing respectively, lifestyle and medication recommendations will be provided for secondary prevention of cardiovascular and cerebrovascular diseases

Intervention type: BEHAVIORAL
Intervention: Life and Medication Recommendations
Description: Based on obtained subjective and objective data from patient-filled questionnaire and laboratory testing respectively, lifestyle and medication recommendations will be provided for secondary prevention of cardiovascular and cerebrovascular diseases
Study: NCT04062552

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Virtual Learning Collaborative
Description: Patients undergo a palliative care assessment, participate in up to 6 ENABLE telehealth sessions with an ENABLE coach (20-45 minutes each), and complete up to 6 monthly follow-up calls over a 26-week period.~The practice sites participate in a VLC consisting of group-based learning sessions, coaching, and applied quality improvement data collection, analysis and feedback opportunities monthly for up to 15 months.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Technical Assistance
Description: Patients undergo a palliative care assessment, participate in up to 6 ENABLE telehealth sessions with an ENABLE coach (20-45 minutes each), and complete up to 6 monthly follow-up calls over a 26-week period.~The practice sites undergo practice-based consultation calls with an ENABLE/TA expert monthly for up to 15 months.
Study: NCT06639373

Intervention type: OTHER
Intervention: Specialized clinical service access
Description: A new model of addiction care that will offer comprehensive and coordinated service delivery
Study: NCT06334211

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FP-020
Description: MMP-12 inhibitor

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: placebo