TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06755697

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Intra-articular US-guided hypertonic dextrose injection, IA group
Description: IA injection: 5 ml of 20% dextrose (2ml vitagen in 2ml normal saline and 1ml 1% xylocain) will be injected. The ultrasound transducer (L18-4, Philips EPI Q5) is placed transversely over the patient's suprapatellar pouch while the patient lies supine with the knee actively extended and ankle dorsiflexed. The injectate will be injected into the suprapatellar pouch via transverse view, in-plane, lateral-to-medial approach with a 3.8 cm 22-gauge needle under US guidance.~Physical therapy: The physical therapy program includes physical modalities (heat therapy and electric therapy) and therapeutic exercise (stretching, ROM exercise, and strengthening), three times a week, and will be continued for 4 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Extra-articular US-guided injection targeting MRI-positive lesion sites, EA group.
Description: Patients in the EA group will receive MRI examination of the knee without contrast. Detailed physical examinations (PE) will also be done for each subject. The PEs include inspection, palpation for local tenderness and crepitus, signs of effusion, assessment of range of motion, provocative meniscal testing, and ligamentous tests for laxity. A total of 5 ml of 20% dextrose (2ml vitagen in 2ml normal saline and 1ml 1% xylocain) will be injected to the target areas which has been shown abnormal on MRI images with a 3.8 cm 22-gauge needle under US guidance. For lesions of the deep structures or bone marrow lesion, a 7-cm 23 or 21 gauge needles may be used. Same as the IA group, EA hypertonic dextrose injection will be done at the 0, 2nd, and 4th weeks, as well as physical therapy during the first 4 weeks.
Study: NCT06751745

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online Emotional Intelligence Training
Description: The intervention is a 4-week online Emotional Intelligence (EI) training program for Bangladeshi youth. It includes weekly one-hour sessions focusing on self-awareness, self-regulation, social awareness, and relationship management. Led by experts, the program uses interactive activities and practical exercises to enhance emotional skills. Pre- and post-training assessments with the Bengali Emotional Intelligence Scale measure outcomes.
Study: NCT06751680

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Rhomboid Intercostal and Subserratus Plane Block
Description: Upon entry, electrocardiogram (ECG), blood pressure, and oxygen saturation were monitored. The patient is placed in the prone position with their arms abducted and internally rotated. Ultrasound equipment (SonoSite Edge II; Fujifilm SonoSite, Bothell, WA, USA) with a linear 13-6 MHz transducer (HFL50x; Fujifilm SonoSite, Bothell, WA, USA) was used. Each nerve block was performed by initially injecting a 5 mL test dose, observing for clinical signs of pain relief in the affected thoracic dermatome, and then injecting the remaining volume of medication after confirmation of the injection site. Patients received ultrasound-guided nerve blocks every 48 hours, for a total of three treatments.The RISS block is a composite nerve block technique that involves two injection sites, located in the inter-rhomboid plane and the sub-serratus plane, respectively. The choice of block plane depended on the patient's site of pain.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: PVB block
Description: The patient is placed in the prone position with their arms abducted and internally rotated. Ultrasound equipment (SonoSite Edge II; Fujifilm SonoSite, Bothell, WA, USA) with a linear 13-6 MHz transducer (HFL50x; Fujifilm SonoSite, Bothell, WA, USA) was used. Each nerve block was performed by initially injecting a 5 mL test dose, observing for clinical signs of pain relief in the affected thoracic dermatome, and then injecting the remaining volume of medication after confirmation of the injection site. Patients received ultrasound-guided nerve blocks every 48 hours, for a total of three treatments.After confirming needle tip placement, 10 mL of 0.5% ropivacaine with 10 mg of triamcinolone acetonide was slowly injected in divided doses, observing for the spread of the local anesthetic to ensure adequate distribution within the PVS for effective block. If multiple nerves were involved, the injection sites were spaced one thoracic vertebral segment apart.
Study: NCT06752603

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-1110
Description: ONO-1110 tablets once a day

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablets once daily
Study: NCT04604951

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneous Spinal Cord Stimulation
Description: This non-invasive therapeutic modality uses electrodes applied over the skin to deliver electrical stimulation. It is based on the same principles of ground-breaking work from the investigator's group and others, showing that stimulation of the spinal cord can promote motor and autonomic (cardiovascular, bladder, bowel) recovery in individuals with chronic SCI.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneous Spinal Cord Stimulation
Description: This non-invasive therapeutic modality uses electrodes applied over the skin to deliver electrical stimulation. It is based on the same principles of ground-breaking work from the investigator's group and others, showing that stimulation of the spinal cord can promote motor and autonomic (cardiovascular, bladder, bowel) recovery in individuals with chronic SCI.
Study: NCT05235412

Intervention type: OTHER
Intervention: Not applicable: Observational study without any interventions.
Description: Exposures of interest: Maternal diet and lifestyle, demographics, anthropometrics, infant's health outcomes
Study: NCT04175639

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mobile Health Pain Coping Skills Training (mPCST)
Description: Participating in Mobile Health Pain Coping Skills Training will involve four 50-minute individual intervention sessions conducted over the course of 8 weeks with tele-video-conferencing at patient's community-based clinic. The therapist delivering the intervention will be at Duke University Medical Center, and patients will be at their community clinic.
Study: NCT05028218

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TQB3824 tablets
Description: TQB3824 is a CDC7 inhibitor, which plays important roles in the maintenance of DNA replication forks and DNA damage response pathways.
Study: NCT05415813

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Ischemic Compression
Description: It includes conventional Physical therapy, hot packs (75°C) for 20 minutes, and active stretching exercises for the upper trapezius muscle (slow, 5 repetitions per session, 10-second hold, and 10-second relaxation between two repetitions) as a baseline treatment. For the Ischemic compression, the patient will be in the supine position with the cervical spine in opposite lateral flexion to the treating part so that the upper trapezius muscle fibers were kept in a lengthened position physiotherapist will apply gradually increasing pressure to the Trigger points until the subject perceived the first noticeable pain. At that moment, the pressure will be maintained until the discomfort and/or pain eased by around 50% as perceived by the patient, at which time the pressure will be increased until the discomfort appears again. This process will be maintained for 90 seconds.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ischemic compression with Muscle Energy Technique
Description: The Participants will receive all the treatments given to the active comparator group and they will also receive the Muscle Energy Technique treatment in supine position and the practitioner will stabilize the shoulder of the affected side with one hand, while the ear/mastoid area of the affected side will be held by the opposite hand. The head and neck were then bent towards the contralateral side, flexed, and ipsilaterally rotated. The subjects will then shrug the stabilized shoulder towards the ear at a sub-maximal pain-free effort (20% of the available strength). The isometric contraction will be held for 7-10s. This position will be maintained for 30 seconds and repeated three to five times per treatment session. Treatment sessions will be given on alternate days.
Study: NCT04118153

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Abatacept
Description: Abatacept will be administered by subcutaneous injections weekly for 3 months. Dosing is according to body weight at screening visit and will be administered as follows: up to 25 kg receive 50 mg (0.4 mL); 25 to \<50 kg receive 87.5 mg (0.7 mL), and \> 50 kg receive 125 mg (1.0 mL) per dose.
Study: NCT05938647

Intervention type: OTHER
Intervention: Risk factor: group 3
Description: Severe dengue, no shock. No diagnostic or therapeutic intervention; the characteristics of participants will be analyzed by demographics, severity, laboratory results, fluids accumulation, and outcomes.

Intervention type: OTHER
Intervention: Risk factor: group 4
Description: Dengue shock syndrome. No diagnostic or therapeutic intervention; the characteristics of participants will be analyzed by demographics, severity, laboratory results, fluids accumulation, and outcomes
Study: NCT06234462

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amantadine
Description: Participants that have been randomized to the study group will be instructed to begin taking amantadine on the day after this study visit. They will self-administer amantadine 100 mg twice daily (morning and noon) for four weeks

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Physical, Occupational, Speech Therapy
Description: Physical Therapy (PT) and Occupational Therapy (OT) train patients on breathing exercises and gradual reconditioning. Patients are referred to speech therapy (SLP) for cognitive remediation and metacognitive strategies.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical, Occupational, Speech Therapy
Description: Physical Therapy (PT) and Occupational Therapy (OT) train patients on breathing exercises and gradual reconditioning. Patients are referred to speech therapy (SLP) for cognitive remediation and metacognitive strategies.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Provider Counseling
Description: Clinic providers will provide counseling/education on Long-COVID.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Provider Counseling
Description: Clinic providers will provide counseling/education on Long-COVID.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Medications for symptoms management
Description: Clinic providers may recommend targeted pharmacologic management for symptoms the patient is experience. As an example, if a patient reports a headache the provider may recommend over-the-counter or prescription medications to target this particular symptom.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Medications for symptoms management
Description: Clinic providers may recommend targeted pharmacologic management for symptoms the patient is experience. As an example, if a patient reports a headache the provider may recommend over-the-counter or prescription medications to target this particular symptom.
Study: NCT05910528

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RO7790121
Description: RO7790121 will be administered during the Induction, Maintenance and OLE period.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RO7790121
Description: RO7790121 will be administered during the Induction, Maintenance and OLE period.
Study: NCT06293456

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dignity Therapy
Description: A trained research staff member will conduct the DT interview virtually. The interview will occur or by phone only if the participant lacks access to technology for videoconferencing. The interviewer asks a series of open-ended questions that encourages patients to talk about their lives and what matters most to them.
Study: NCT06755489

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 530 mg tablets containing microcrystalline cellulose, rice bran, bitter cocoa powder table 530 mg. 1 tablet three times a day

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 530 mg tablets containing microcrystalline cellulose, rice bran, bitter cocoa powder table 530 mg. 1 tablet three times a day

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: GABA
Description: 530 mg tablets containing Gamma-aminobutyric acid (GABA) and different bulking agent as microcrystalline cellulose, calcium carbonate, lemon balm d.e. Leaves (melissa officinalis l. - maltodextrin) tit. 2% in rosmarinic acid, anti-caking agents: silicon dioxide, vegetable magnesium stearate. 1 tablet three times a day

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: GABA
Description: 530 mg tablets containing Gamma-aminobutyric acid (GABA) and different bulking agent as microcrystalline cellulose, calcium carbonate, lemon balm d.e. Leaves (melissa officinalis l. - maltodextrin) tit. 2% in rosmarinic acid, anti-caking agents: silicon dioxide, vegetable magnesium stearate. 1 tablet three times a day
Study: NCT05461872

Intervention type: OTHER
Intervention: No intervention
Description: No intervention
Study: NCT06164470

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Support Group
Description: monthly virtual patient support with multidisciplinary education for 12 sessions
Study: NCT06477575

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: neurocognitive therapy based on new technologies
Description: The cognitive neurorehabilitation program is based on gaming through the use of the Nintendo Switch device. The following games have been chosen: Pufferfish, Hex Egg, Mystic Totem, Thor's Thunder, since they are games that work on selective attention, concentration and processing speed, which are the variables to be studied in this project.~Hardware: Nintendo Switch Software: 60 in 1 game Games: Pufferfish, Hex Egg, Mystic Totem, Thor's Thunder. Therapy time: 30 minutes effective. Number of Sessions: 2 per week / Number of weeks: 8 Total number of intervention sessions: 16 sessions Place: Thercli Center (Don Benito).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional neurocognitive therapy
Description: The cognitive neurorehabilitation program for group active comparator is based on playing more conventional board games that work on selective attention, concentration and processing speed, which are the variables to be studied in this project.~Traditional games and token book. Games: Dobble, Lynx, Crazy cups, Jungle speed, animalea, ghost. Card: Stimulate and learn level 3 and 4. Therapy time: 30 minutes effective. No. of sessions: 2 per week / No. of weeks: 8 Total number of intervention sessions: 16 sessions Place: Thercli Center (Don Benito).
Study: NCT04134455

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mesh reinforcement
Description: Once the surgery is over. The closure is made with the 4: 1 rule, then an onlay mesh is placed that exceeds 3 cm on each side the wound is fixed with suture.
Study: NCT06143826

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Progressive muscle relaxation exercises
Description: Progressive muscle relaxation exercises involve contracting and relaxing 16 muscle groups in the body (hand, upper arm, forearm, forehead, nose, cheek, chin, neck, shoulder, chest, abdomen, waist, stomach, calf, hip, foot). During the exercise, the individual perceives the changes in the muscles during the contraction and relaxation of the muscles. Relaxation exercise is applied along with correct and deep breathing.
Study: NCT04134455

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: RTL reinforcement
Description: Once the surgery is finished, the ared is reinforced by placing a longitudinal suture parallel to the edge of the wound 0.5 cm, then the wound is closed with a 4: 1 rule but the suture enters lateral to the reinforcement suture
Study: NCT06505707

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health Seeking Behavior Training Based on Motivational Interviewing Techniques
Description: The Effect of Health Seeking Behavior Training Based on Motivational Interviewing Techniques on Health Seeking Behavior, Illness Self-Management and Anxiety in Migrant Elderly Women with Chronic Diseases.
Study: NCT06418724

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cetuximab
Description: Cetuximab is a monoclonal antibody against epidermal growth factor receptor (EGFR). EGFR is over-expressed in many human cancers, including colorectal cancers.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cemiplimab
Description: Cemiplimab is a fully human immunoglobulin G4 (IgG4) monoclonal antibody that binds to the programmed cell death-1 (PD-1) receptor and blocks its interaction with its ligands programmed death-ligand 1 (PD-L1) and programmed death-ligand 2 (PD-L2). Engagement of PD-1 with its ligands PD-L1 and PD-L2, which are expressed by antigen presenting cells and may be expressed by tumour cells and/or other cells in the tumour microenvironment, results in inhibition of T cell function such as proliferation, cytokine secretion, and cytotoxic activity. Cemiplimab potentiates T cell responses, including antitumour responses, through blockade of PD-1 binding to PD-L1 and PD-L2 ligands.
Study: NCT05276375

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bronchipret
Description: Bronchipret syrup (3x 5,4 ml daily) until day 14
Study: NCT05720338

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: 19 French Blake Drain
Description: 19 French Blake Intraperitoneal Drain will be placed near the pancreatic resection margin
Study: NCT06095297

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Processing Speed Training
Description: Speed of processing training involves trainer-guided practice of computer-based video games. The games require the player to rapidly distinguish targets from decoys, which trains how rapidly the player processes information received through their senses.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Processing Speed Training
Description: Speed of processing training involves trainer-guided practice of computer-based video games. The games require the player to rapidly distinguish targets from decoys, which trains how rapidly the player processes information received through their senses.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: In-lab Instrumental Activities of Daily Living Training
Description: Participant will receive shaping on IADLS. Participants will receive training on everyday tasks with important cognitive components, in which the difficulty is increased in small steps over the course of treatment.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: In-lab Instrumental Activities of Daily Living Training
Description: Participant will receive shaping on IADLS. Participants will receive training on everyday tasks with important cognitive components, in which the difficulty is increased in small steps over the course of treatment.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: In-lab Brain Health Training
Description: Participants will receive training on healthy eating, sleeping, and relaxation techniques that have been shown to improve brain health.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: In-lab Brain Health Training
Description: Participants will receive training on healthy eating, sleeping, and relaxation techniques that have been shown to improve brain health.
Study: NCT06115642

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HLX43
Description: HLX43 is an anti-PD-L1 monoclonal antibody conjugated with a novel high potency DNA topoisomerase I (topo I) inhibitor, with a drug-antibody-ratio (DAR) of 8.
Study: NCT05028153

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Azithromycin Oral Liquid Product
Description: 10 mg/kg for 3 consecutive days

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo mixture
Description: Placebo mixture containing no active substance
Study: NCT06022510

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Fetoscopy Sets for Anterior and Posterior Placentas
Description: Patients who choose to undergo fetoscopic surgery for a complicated monochorionic-diamniotic pregnancy will be offered participation in this study. All patients will undergo selective laser photocoagulation with the use of the fetoscopes in this study.
Study: NCT05486091

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: App-Enhanced Brief Cognitive-Behavioral Therapy
Description: BCBT is a cognitive-behavioral intervention designed to target core skills deficits among suicidal individuals. App-enhanced BCBT incorporates the use of a SmartPhone app during the therapy sessions.
Study: NCT05107817

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise intervention
Description: A ball catching and throwing exercise.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercise intervention
Description: A ball catching and throwing exercise.
Study: NCT06051266

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dynamic navigation
Description: Dynamic navigation eliminates the need for a laboratory fabrication process and allows for direct visualisation of the operative area during implant placement. Moreover, it can avoid interfering with water cooling. Navigation-assisted surgery makes it possible to modify the implant system, length, diameter or position in real time, both in the perioperative period and during surgery.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Static template
Description: In most clinical situations, a static template can be used to assist in guiding the placement of implants precisely. The static guide has some limitations in that it requires additional fabrication time, has insufficient cooling in the surgical field and is not suitable for simultaneous grafting procedures.