Study: NCT05074875

Intervention type: OTHER
Intervention: Questionnaires and Patient Reported Outcomes (PROs)
Description: * EuroQol 5 Dimensional Quality of Life Questionnaire (EQ-5D).~* St. George's Respiratory Questionnaire (SGRQ)~* Impact of Events Scale Revised (IES-R)~* Generalized Anxiety Disorder 7-Item (GAD-7)~* Patient Health Questionnaire (PHQ-9)

Intervention type: OTHER
Intervention: Questionnaires and Patient Reported Outcomes (PROs)
Description: * EuroQol 5 Dimensional Quality of Life Questionnaire (EQ-5D).~* St. George's Respiratory Questionnaire (SGRQ)~* Impact of Events Scale Revised (IES-R)~* Generalized Anxiety Disorder 7-Item (GAD-7)~* Patient Health Questionnaire (PHQ-9)

Intervention type: OTHER
Intervention: Questionnaires and Patient Reported Outcomes (PROs)
Description: * EuroQol 5 Dimensional Quality of Life Questionnaire (EQ-5D).~* St. George's Respiratory Questionnaire (SGRQ)~* Impact of Events Scale Revised (IES-R)~* Generalized Anxiety Disorder 7-Item (GAD-7)~* Patient Health Questionnaire (PHQ-9)

Intervention type: OTHER
Intervention: Questionnaires and Patient Reported Outcomes (PROs)
Description: * EuroQol 5 Dimensional Quality of Life Questionnaire (EQ-5D).~* St. George's Respiratory Questionnaire (SGRQ)~* Impact of Events Scale Revised (IES-R)~* Generalized Anxiety Disorder 7-Item (GAD-7)~* Patient Health Questionnaire (PHQ-9)

Intervention type: DIAGNOSTIC_TEST
Intervention: Nasal Swab COVID-19 reverse transcription polymerase chain reaction test (RT-PCR)
Description: If required by the local site's COVID-19 guidelines, subjects should have the COVID-19 RT-PCR Nasal Swab collected at the beginning of the visit or within 5 days prior to the scheduled visit.

Intervention type: DIAGNOSTIC_TEST
Intervention: Nasal Swab COVID-19 reverse transcription polymerase chain reaction test (RT-PCR)
Description: If required by the local site's COVID-19 guidelines, subjects should have the COVID-19 RT-PCR Nasal Swab collected at the beginning of the visit or within 5 days prior to the scheduled visit.

Intervention type: DIAGNOSTIC_TEST
Intervention: Nasal Swab COVID-19 reverse transcription polymerase chain reaction test (RT-PCR)
Description: If required by the local site's COVID-19 guidelines, subjects should have the COVID-19 RT-PCR Nasal Swab collected at the beginning of the visit or within 5 days prior to the scheduled visit.

Intervention type: DIAGNOSTIC_TEST
Intervention: Nasal Swab COVID-19 reverse transcription polymerase chain reaction test (RT-PCR)
Description: If required by the local site's COVID-19 guidelines, subjects should have the COVID-19 RT-PCR Nasal Swab collected at the beginning of the visit or within 5 days prior to the scheduled visit.

Intervention type: GENETIC
Intervention: Blood Samples for Biomarkers
Description: Venous blood will be collected using pre-labeled tubes.

Intervention type: GENETIC
Intervention: Blood Samples for Biomarkers
Description: Venous blood will be collected using pre-labeled tubes.

Intervention type: GENETIC
Intervention: Blood Samples for Biomarkers
Description: Venous blood will be collected using pre-labeled tubes.

Intervention type: GENETIC
Intervention: Blood Samples for Biomarkers
Description: Venous blood will be collected using pre-labeled tubes.

Intervention type: DIAGNOSTIC_TEST
Intervention: High Resolution Computed Tomography
Description: Subjects will have HRCTs at Visits 1, 2, 3, and 4. Inpatient HRCT scans will be collected during the baseline visit (V0 or V1)

Intervention type: DIAGNOSTIC_TEST
Intervention: High Resolution Computed Tomography
Description: Subjects will have HRCTs at Visits 1, 2, 3, and 4. Inpatient HRCT scans will be collected during the baseline visit (V0 or V1)

Intervention type: DIAGNOSTIC_TEST
Intervention: High Resolution Computed Tomography
Description: Subjects will have HRCTs at Visits 1, 2, 3, and 4. Inpatient HRCT scans will be collected during the baseline visit (V0 or V1)

Intervention type: DIAGNOSTIC_TEST
Intervention: High Resolution Computed Tomography
Description: Subjects will have HRCTs at Visits 1, 2, 3, and 4. Inpatient HRCT scans will be collected during the baseline visit (V0 or V1)

Intervention type: DIAGNOSTIC_TEST
Intervention: Physical Exam and Vital Signs
Description: A complete physical exam, including height, weight, general appearance, neck, lungs, cardiovascular system, abdomen, extremities, and skin will be performed at Visit 1.A brief physical exam will be completed at subsequent visits, including weight, general appearance, lungs, cardiovascular symptoms, extremities, and other body systems pertinent to the participants health status, at the discretion of the investigator.~Blood pressure, heart rate, and oxygen saturation will be collected at all visits, prior to blood draws and after subjects have rested.

Intervention type: DIAGNOSTIC_TEST
Intervention: Physical Exam and Vital Signs
Description: A complete physical exam, including height, weight, general appearance, neck, lungs, cardiovascular system, abdomen, extremities, and skin will be performed at Visit 1.A brief physical exam will be completed at subsequent visits, including weight, general appearance, lungs, cardiovascular symptoms, extremities, and other body systems pertinent to the participants health status, at the discretion of the investigator.~Blood pressure, heart rate, and oxygen saturation will be collected at all visits, prior to blood draws and after subjects have rested.

Intervention type: DIAGNOSTIC_TEST
Intervention: Physical Exam and Vital Signs
Description: A complete physical exam, including height, weight, general appearance, neck, lungs, cardiovascular system, abdomen, extremities, and skin will be performed at Visit 1.A brief physical exam will be completed at subsequent visits, including weight, general appearance, lungs, cardiovascular symptoms, extremities, and other body systems pertinent to the participants health status, at the discretion of the investigator.~Blood pressure, heart rate, and oxygen saturation will be collected at all visits, prior to blood draws and after subjects have rested.

Intervention type: DIAGNOSTIC_TEST
Intervention: Physical Exam and Vital Signs
Description: A complete physical exam, including height, weight, general appearance, neck, lungs, cardiovascular system, abdomen, extremities, and skin will be performed at Visit 1.A brief physical exam will be completed at subsequent visits, including weight, general appearance, lungs, cardiovascular symptoms, extremities, and other body systems pertinent to the participants health status, at the discretion of the investigator.~Blood pressure, heart rate, and oxygen saturation will be collected at all visits, prior to blood draws and after subjects have rested.

Intervention type: DIAGNOSTIC_TEST
Intervention: Medical Research Council Sum Score
Description: The Medical Research Council Sum Score (MRC-SS) is used globally to detect peripheral muscle strength and to help diagnose ICU-acquired muscle weakness. The MRC-SS ranging from 0 (complete paralysis) to 60 (normal).

Intervention type: DIAGNOSTIC_TEST
Intervention: Medical Research Council Sum Score
Description: The Medical Research Council Sum Score (MRC-SS) is used globally to detect peripheral muscle strength and to help diagnose ICU-acquired muscle weakness. The MRC-SS ranging from 0 (complete paralysis) to 60 (normal).

Intervention type: DIAGNOSTIC_TEST
Intervention: Medical Research Council Sum Score
Description: The Medical Research Council Sum Score (MRC-SS) is used globally to detect peripheral muscle strength and to help diagnose ICU-acquired muscle weakness. The MRC-SS ranging from 0 (complete paralysis) to 60 (normal).

Intervention type: DIAGNOSTIC_TEST
Intervention: Medical Research Council Sum Score
Description: The Medical Research Council Sum Score (MRC-SS) is used globally to detect peripheral muscle strength and to help diagnose ICU-acquired muscle weakness. The MRC-SS ranging from 0 (complete paralysis) to 60 (normal).

Intervention type: DIAGNOSTIC_TEST
Intervention: Hand Grip Strength
Description: Each subject will have hand grip strength measured at each visit. This is being done in order to assess the maximum isometric strength of hand and forearm muscles.

Intervention type: DIAGNOSTIC_TEST
Intervention: Hand Grip Strength
Description: Each subject will have hand grip strength measured at each visit. This is being done in order to assess the maximum isometric strength of hand and forearm muscles.

Intervention type: DIAGNOSTIC_TEST
Intervention: Hand Grip Strength
Description: Each subject will have hand grip strength measured at each visit. This is being done in order to assess the maximum isometric strength of hand and forearm muscles.

Intervention type: DIAGNOSTIC_TEST
Intervention: Hand Grip Strength
Description: Each subject will have hand grip strength measured at each visit. This is being done in order to assess the maximum isometric strength of hand and forearm muscles.

Intervention type: DIAGNOSTIC_TEST
Intervention: Spirometry
Description: Spirometry will be assessed at Visits 1, 2, 3 and 4. Each site will use its own spirometry machine. Each subject should use the same machine at each visit and conduct measurements at approximately the same time. Before any testing, the maneuver should be demonstrated to the subject. The spirometry should be reviewed by the investigator.

Intervention type: DIAGNOSTIC_TEST
Intervention: Spirometry
Description: Spirometry will be assessed at Visits 1, 2, 3 and 4. Each site will use its own spirometry machine. Each subject should use the same machine at each visit and conduct measurements at approximately the same time. Before any testing, the maneuver should be demonstrated to the subject. The spirometry should be reviewed by the investigator.

Intervention type: DIAGNOSTIC_TEST
Intervention: Spirometry
Description: Spirometry will be assessed at Visits 1, 2, 3 and 4. Each site will use its own spirometry machine. Each subject should use the same machine at each visit and conduct measurements at approximately the same time. Before any testing, the maneuver should be demonstrated to the subject. The spirometry should be reviewed by the investigator.

Intervention type: DIAGNOSTIC_TEST
Intervention: Spirometry
Description: Spirometry will be assessed at Visits 1, 2, 3 and 4. Each site will use its own spirometry machine. Each subject should use the same machine at each visit and conduct measurements at approximately the same time. Before any testing, the maneuver should be demonstrated to the subject. The spirometry should be reviewed by the investigator.

Intervention type: DIAGNOSTIC_TEST
Intervention: Diffusing Capacity of Carbon Monoxide
Description: The site will use its own DLCO equipment for measurements at Visits, 1, 2, 3, and 4. The Single-breath DLCO maneuver will be carried out in accordance with the 2017 American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. Subjects should use the same device at approximately that same time at each visit. The maneuver should be demonstrated to the subject prior to the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: Diffusing Capacity of Carbon Monoxide
Description: The site will use its own DLCO equipment for measurements at Visits, 1, 2, 3, and 4. The Single-breath DLCO maneuver will be carried out in accordance with the 2017 American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. Subjects should use the same device at approximately that same time at each visit. The maneuver should be demonstrated to the subject prior to the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: Diffusing Capacity of Carbon Monoxide
Description: The site will use its own DLCO equipment for measurements at Visits, 1, 2, 3, and 4. The Single-breath DLCO maneuver will be carried out in accordance with the 2017 American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. Subjects should use the same device at approximately that same time at each visit. The maneuver should be demonstrated to the subject prior to the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: Diffusing Capacity of Carbon Monoxide
Description: The site will use its own DLCO equipment for measurements at Visits, 1, 2, 3, and 4. The Single-breath DLCO maneuver will be carried out in accordance with the 2017 American Thoracic Society/European Respiratory Society (ATS/ERS) guidelines. Subjects should use the same device at approximately that same time at each visit. The maneuver should be demonstrated to the subject prior to the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 Minute Walk Test
Description: The 6 Minute Walk Test (6MWT) will assess exercise capacity and tolerance. 6MWTs will be conducted at Visits 1, 2, 3, and 4.~The procedure of the 6MWT should be explained and demonstrated to the subject prior to the start of the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 Minute Walk Test
Description: The 6 Minute Walk Test (6MWT) will assess exercise capacity and tolerance. 6MWTs will be conducted at Visits 1, 2, 3, and 4.~The procedure of the 6MWT should be explained and demonstrated to the subject prior to the start of the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 Minute Walk Test
Description: The 6 Minute Walk Test (6MWT) will assess exercise capacity and tolerance. 6MWTs will be conducted at Visits 1, 2, 3, and 4.~The procedure of the 6MWT should be explained and demonstrated to the subject prior to the start of the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 Minute Walk Test
Description: The 6 Minute Walk Test (6MWT) will assess exercise capacity and tolerance. 6MWTs will be conducted at Visits 1, 2, 3, and 4.~The procedure of the 6MWT should be explained and demonstrated to the subject prior to the start of the test.

Intervention type: DIAGNOSTIC_TEST
Intervention: Sit to Stand (STS) Measurement
Description: The STS will be conducted at Visits 1, 2, 3, and 4 to assess the physical functioning of the adult participants.

Intervention type: DIAGNOSTIC_TEST
Intervention: Sit to Stand (STS) Measurement
Description: The STS will be conducted at Visits 1, 2, 3, and 4 to assess the physical functioning of the adult participants.

Intervention type: DIAGNOSTIC_TEST
Intervention: Sit to Stand (STS) Measurement
Description: The STS will be conducted at Visits 1, 2, 3, and 4 to assess the physical functioning of the adult participants.

Intervention type: DIAGNOSTIC_TEST
Intervention: Sit to Stand (STS) Measurement
Description: The STS will be conducted at Visits 1, 2, 3, and 4 to assess the physical functioning of the adult participants.