TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06315257

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PVX7
Description: PVX7 Immunotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PVX7
Description: PVX7 Immunotherapy
Study: NCT05281731

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sonobiopsy
Description: Ultrasound combined with microbubbles to facilitate sampling of biomarkers from brain tumors via blood-based liquid biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Research blood
Description: No more than 10 minutes prior to ultrasound sonication, 10 minutes after ultrasound sonication, 30 minutes after ultrasound sonication (optional at the discretion of the PI), and 60 minutes after ultrasound sonication (optional at the discretion of the PI)

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Cancer Personalized Profiling
Description: Cancer Personalized Profiling by deep Sequencing will be used to compare the frequency of tumor-specific variants in the blood before and after sonobiopsy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Definity®
Description: Being used off-label in this trial
Study: NCT06084208

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Biopsy with the Robotic- Ion Endoluminal System with Adjunct Real-time Imaging
Description: Biopsy with the Robotic- Navigational Bronchoscopy System with Cone Beam Computed Tomography (CBCT)
Study: NCT06117462

Intervention type: OTHER
Intervention: Assesment of CFS
Description: Assesment of CFS

Intervention type: OTHER
Intervention: Assesment of CFS
Description: Assesment of CFS
Study: NCT04617093

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: PrismaLung+
Description: Overall, up to 60 adult patients will be initiated on ECCO2R using PrismaLung+. A minimum of approximately 15 patients will be treated with ECCO2R using PrismaLung+ as stand-alone therapy and another minimum of approximately 15 patients (maximum of 20) will receive ECCO2R using PrismaLung+ in combination with CRRT.
Study: NCT05009797

Intervention type: PROCEDURE
Intervention: atrial fibrillation catheter ablation
Description: The ablation is performed under local anesthesia or general anesthesia. A transseptal puncture will be performed to access the left atrium. Pulmonary vein isolation will be performed as a first step. Additional lesions will be made at the discretion of the operators. Patients will receive anticoagulation for at least 3 months after the ablation. Treatment thereafter will be extended at the discretion of the treating physician.
Study: NCT05033964

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Percutaneous Coronary Intervention with drug eluting stents
Description: Coronary drug eluting stent implantation

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Percutaneous Coronary Intervention with drug eluting stents
Description: Coronary drug eluting stent implantation
Study: NCT04943510

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical exercices
Description: surface EMG: surface electrodes will be positioned on the muscles to evaluate the level of muscle activation~non invasive muscular neurostimulations : application of a percutaneous electrical stimulation of the motor nerve of the considered muscle and a direct electrical stimulation of the muscle
Study: NCT06390020

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: MBSR
Description: The MBSR training spans eight weeks and follows a standardized protocol. It consists of eight weekly sessions, each lasting 2.5 hours, a single 6-hour silent day, and daily home exercises. Additionally, the program incorporates personalized psychoeducation on high sensory processing sensitivity, covering its characteristics, scientific foundations, its relation with stress-related symptoms, and why mindfulness might be helpful.
Study: NCT05902390

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: hydrogel spacer
Description: Randomly assigned to either the treatment group, who were injected with hydrogel spacer, or the control group, who were not injected with hydrogel spacer.
Study: NCT05035771

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Pressure wire measurement in peripheral vascular disease
Description: The aim of IMPACT PAD is to examine the safety and feasibility of intraprocedural flow, pressure and resistance rate changes to help predict the success of a peripheral endovascular intervention.
Study: NCT06205927

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Standard carbon ion beam radiotherapy
Description: The standard treatment arm will receive carbon ion beam radiotherapy of 77Gy (RBE equivalent) per 22 fractions for gross tumor volume.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Carbon ion beam radiotherapy simultaneously dose boost
Description: The hypoxic lesions dose boost arm will receive 77Gy (RBE equivalent) per 22 fractions for gross tumor volume and a simultaneously dose boost of 83.6Gy (RBE equivalent) per 22 fractions for hypoxic lesions detected by 18F-Misonidazole PET/CT.
Study: NCT04971031

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Reproxalap Ophthalmic Solution (0.25%)
Description: Reproxalap Ophthalmic Solution (0.25%) administered 7 times over two consecutive days.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Vehicle Ophthalmic Solution
Description: Vehicle Ophthalmic Solution administered 7 times over two consecutive days.
Study: NCT05395819

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Reverse Total Shoulder Arthroplasty (RTSA)
Description: Patient will undergo a RTSA as per standard technique. It uses a stemmed metal humeral component attached to the glenoid and the shallow glenoid component attached to the humerus. Pre-operative CT imaging and surgical planning software based on pre-operative CT scans will be used in each case to determine the degree of eccentric (high side) anterior reaming to within \< 10 degrees of neutral glenoid version. Standard instruments including a spherical burr and power reamers will be used to achieve this.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Total Shoulder Arthroplasty (TSA)
Description: Patients will undergo standard glenoid preparation and implantation of a TSA. It uses a stemmed metal humeral component to replace the arthritic head of humerus and a shallow polyethylene glenoid component to replace the arthritic glenoid surface. The degree of anterior- reaming will be based on pre-operative CT scan assessment and templating software with the goal of correcting glenoid retroversion to within 10 degrees of neutral version.
Study: NCT05914727

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: eNose
Description: Collection of breath profile with eNose

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: eNose
Description: Collection of breath profile with eNose

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Volatile exhaled breath sample
Description: Collection of exhaled breath in Tedlar bag

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Volatile exhaled breath sample
Description: Collection of exhaled breath in Tedlar bag

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Condensate sample
Description: Collection of exhaled breath condensate with EcoScreen

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Condensate sample
Description: Collection of exhaled breath condensate with EcoScreen
Study: NCT05137795

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ZYESAMI™ (aviptadil acetate)
Description: Inhaled ZYESAMI™ (aviptadil acetate) 100μg 3x daily by mesh nebulizer

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Normal Saline Inhalation

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Nebulized administration of ZYESAMI™ or Placebo
Description: Use of 510(k) cleared mesh nebulizer to deliver investigational product

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Nebulized administration of ZYESAMI™ or Placebo
Description: Use of 510(k) cleared mesh nebulizer to deliver investigational product
Study: NCT04917406

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Application of lidocaine together with dexamethasone
Description: Lidocaine 2% is applied on the positive pole while dexamethasone 4 mg/ml is applied on the negative pole. Through the use of current the drugs penetrate the fascia.
Study: NCT05620290

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Definity
Description: Stimulation of Definity microbubbles using Sonalleve device within tumour vasculature

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sonalleve Focused Ultrasound Device
Description: Sonalleve Focused Ultrasound Device
Study: NCT04917406

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Application of ultrasound as physical therapy
Description: The application dose will be 0.65 Watt for 7 minutes in the area of most painful affectation by means of a circular movement and a 1MZ head.
Study: NCT05664035

Intervention type: BIOLOGICAL
Intervention: Diagnosis of SPAD using immunization with PPV23
Description: Diagnosis of SPAD using immunization with PPV23
Study: NCT05989243

Intervention type: DEVICE
Intervention: Conventional prosthetic socket
Description: Participants will use their own conventional rigid socket and will be asked to walk on a force-measuring treadmill on level ground at 0.75, 1.0, 1.25, and 1.5 m/s for \~60 sec per speed. They will also be asked to evaluate this socket using a questionnaire.

Intervention type: DEVICE
Intervention: Conventional prosthetic socket
Description: Participants will use their own conventional rigid socket and will be asked to walk on a force-measuring treadmill on level ground at 0.75, 1.0, 1.25, and 1.5 m/s for \~60 sec per speed. They will also be asked to evaluate this socket using a questionnaire.
Study: NCT05268718

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel
Description: Hollow gold and silver alloy cuprous oxide shell nano-shell hydrogel was excited by NIR laser to release functional silver ions, copper ions and ROS.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Voriconazole eye drops
Description: Voriconazole eye drops (1%) were administrated to infectious eye very frequently (once half an hour)

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Normal saline
Description: To be placebo, normal saline were administrated to infectious eye
Study: NCT05989243

Intervention type: DEVICE
Intervention: Adjustable Quatro socket
Description: Participants will use an adjustable Quatro socket and will be asked to walk on a force-measuring treadmill on level ground at 0.75, 1.0, 1.25, and 1.5 m/s for \~60 sec per speed. They will also be asked to evaluate this socket using a questionnaire.

Intervention type: DEVICE
Intervention: Adjustable Quatro socket
Description: Participants will use an adjustable Quatro socket and will be asked to walk on a force-measuring treadmill on level ground at 0.75, 1.0, 1.25, and 1.5 m/s for \~60 sec per speed. They will also be asked to evaluate this socket using a questionnaire.
Study: NCT04975386

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transthoracic echocardiogram
Description: Transthoracic echocardiogram will be performed before the operation and at certain time intervals during the operation.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transthoracic echocardiogram
Description: Transthoracic echocardiogram will be performed before the operation and at certain time intervals during the operation.
Study: NCT06406361

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: stress management training
Description: -Nurses should have an idea about stress management training Awareness develops about the importance of attending sessions regularly. Nurses have information about the training program. Joint session dates are determined. The educator makes statements about himself and education. The benefits of education for nurses are explained. Nurses are informed about the general rules of education. The importance of regular attendance at sessions is emphasized. Privacy rules and limits are determined. The necessity of completing homework is explained. Nurses are enabled to share their feelings and thoughts. Ensuring that nurses are able to recognize stress and reactions to stress and identify sources of stress in individual and business life.~Being informed about the effects of stress and workload perception Being able to recognize the tension created by stress in the body Learning breathing and deep relaxation techniques to reduce or eliminate symptoms of stress
Study: NCT04934969

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Adjunctive use of lavender and peppermint essential oils
Description: passive inhalation aromatherapy following joint surgery
Study: NCT05677412

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: suggestive relaxation
Description: suggestive story before sleep onset

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Neutral story
Description: neutral story before sleep
Study: NCT05649059

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cannabidiol
Description: Participants randomized to the cannabidiol arm will receive 3mL of Epidiolex (100mg cannabidiol/mL) in a single-dose.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants randomized to the placebo arm will receive 3mL of placebo (sesame seed oil) in a single dose.
Study: NCT05878405

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Anti-inflammatory/Antimicrobial/Analgesic Aqueous Mouth Rinse
Description: Given PO

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Methylene Blue Oral Rinse
Description: Given PO
Study: NCT06136221

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: LiverWatch Intervention
Description: The LiverWatch Intervention will include standard cirrhosis care and include additional components utilizing the W2H system. Details on this intervention are included in the study arm description.
Study: NCT05851560

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oxidized regenerated cellulose(ORC)
Description: Investigate the antiadhesive effect of multiple antiadhesive barriers in thyroid surgery

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hyaluronic acid(HA)
Description: Hyaluronic acid(HA)
Study: NCT04441567

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Right-size clinic visits
Description: The curve created in Phase 1 will be used to guide the number of clinic visits based on PROMs reported by the participants in Phase 2.
Study: NCT05570578

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: HD-tDCS
Description: The anode electrode will be placed over Broca's area, 4 cathode electrodes will be placed at about 2 cm distance each from the anode in 4 directions.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: HD-tDCS
Description: The anode electrode will be placed over Broca's area, 4 cathode electrodes will be placed at about 2 cm distance each from the anode in 4 directions.
Study: NCT05130359

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: take 2 tablets 2 hours before bedtime for 4 consecutive weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Banana peel extract
Description: take 2 tablets 2 hours before bedtime for 4 consecutive weeks
Study: NCT06228209

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tier - Palliative Care
Description: TIER-PC is an adaptive model of delivering palliative care that provides the right level of care to the right patients at the right time. It represents an adaption of the Mount Sinai PALLIATIVE CARE AT HOME (PC@H) program, which delivers home-based palliative care. TIER-PC increases the number and intensity of disciplines added to the patient's care team as their symptoms worsen and function declines.
Study: NCT06568523

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: MAGENTIQ-COLO.
Description: This is a diagnostic performance study; no randomization will be conducted. All subjects will undergo the same study procedures. The endoscopist performing the examinations cannot be blinded for the output of the investigational device in this study. Due to the nature of the intervention, it is not guaranteed that the patient is not awake during the procedure, therefore blinding for the patient is also not feasible.
Study: NCT06496360

Intervention type: DIAGNOSTIC_TEST
Intervention: Artificial Intelligence
Description: The model employs machine learning algorithms to analyze CT imaging data of patients with non-small cell lung cancer. It focuses on the identification and assessment of features of the mediastinal fourth group lymph nodes, including size, shape, margins, and density. By extracting features related to lymph node metastasis, the model assists doctors in making more accurate diagnoses.

Intervention type: DIAGNOSTIC_TEST
Intervention: Artificial Intelligence
Description: The model employs machine learning algorithms to analyze CT imaging data of patients with non-small cell lung cancer. It focuses on the identification and assessment of features of the mediastinal fourth group lymph nodes, including size, shape, margins, and density. By extracting features related to lymph node metastasis, the model assists doctors in making more accurate diagnoses.
Study: NCT06019975

Intervention type: DIAGNOSTIC_TEST
Intervention: FDG-PET
Description: Brain FDG-PET
Study: NCT06019416

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: culturally tailored mindfulness-positive psychological intervention
Description: This 3-week culturally tailored mindfulness-positive psychological intervention instructs techniques to enhance positive emotions and meditation exercise lasting approximately 30 minutes. The culturally tailored mindfulness-positive psychological intervention consists of four modules: 1) noticing positive events, 2) amplifying positive events, 3) gratitude, and 4) mindfulness and meditation. This 3-dimensional software includes gamification features, including a virtual living room, Japanese garden, art gallery, and meditation garden.~A private office and/or space was utilized to implement the culturally tailored mindfulness-positive psychological intervention for older Korean Americans/immigrants, provided by the recruitment sites such as non-profit organization and church. The private room at the sites had a desktop (or laptop) computer, a virtual reality device (Oculus Quest 2), a chair, and a desk.
Study: NCT05244031

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: superficial erector spina plane block
Description: The investigators performed superficial erector spina plane block to that patient group for postoperative analgesia

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Standard (opioid-based) analgesia
Description: The investigators performed intravenous opioid infusion with PCA to that patient group for postoperative analgesia
Study: NCT05206513

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Capsule, administered once daily orally or via gastrostomy/gastrojejunostomy tube

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Valbenazine
Description: Capsule, administered once daily orally or via gastrostomy/gastrojejunostomy tube

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Valbenazine
Description: Capsule, administered once daily orally or via gastrostomy/gastrojejunostomy tube
Study: NCT05317975

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Add-on telerehabilitation and home-based rehabilitation
Description: 1. 12wk home-based rehabilitation including individualized exercise training and inspiratory muscle training with symptoms monitoring. Participants will be provided with a manual and routine telephone follow-up by a case manager.~2. Add-on telerehabilitation for instruction and supervision of exercise training

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Home-based rehabilitation alone
Description: 12wk home-based rehabilitation including individualized exercise training and inspiratory muscle training with symptoms monitoring. Participants will be provided with a manual and routine telephone follow-up by a case manager.
Study: NCT05641740

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Single-session of Radiofrequency
Description: The experimental group continue with their usual conservative and pharmacological treatment and will receive a single-session of monopolar dielectric capacitive radiofrequency in their hands. An Biotronic Advance Develops® (ABD-S25v) with a carrier wave frequency of 800-900 KHz of 850 KHz will be used. Patients will be placed in a seated position, with the forearms supinated and resting on a wooden table. An almond oil conductor will be applied to the hands. The application will be carried out with a circular head of 5 cm2 and for a total of 10 minutes on each of the palms of the hands.~They will be evaluated at baseline and post-session.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Control Placebo single-session of Radiofrequency
Description: The control placebo group continue with their usual conservative and pharmacological treatment and will receive a placebo single-session of radiofrequency. This group will follow the same protocol and treatment time, but they will receive a placebo treatment (the device remains in paused mode), so that radiofrequency will not be applied.~They will be evaluated at baseline and post-session.
Study: NCT05817864

Intervention type: DIAGNOSTIC_TEST
Intervention: Capnography
Description: Index test: Capnography, which monitors ETCO2, the percentage concentration, or partial pressure of CO2 at the end of exhalation, will serve as the index test. It will be performed by connecting the end of the nasogastric tube with the sensor of the bedside sidestream capnography device. Placement within the airway is defined as detecting a capnogram waveform or an ETCO2 level \> 10 mmHg.~Reference standard: This study will use radiography (chest/abdominal X-ray) as the reference standard for determining the correct placement of nasogastric tubes. Radiology will be performed as soon as possible and interpreted by a physician. A repeat radiography will be performed if necessary. We will also use pH-Fix-4.5-10 to determine the pH value, and its accuracy is +/- 0.2 pH with minimum increments of 0.5. A pH of 5.5 or below indicates gastric placement.
Study: NCT05722275

Intervention type: DIAGNOSTIC_TEST
Intervention: Peritoneal metastasis status ascertainment
Description: Each participant with gastric cancer will undergo enhanced CT examination for detection of peritoneal metastasis. Within two weeks of CT examination, the participant will undergo diagnostic laparoscopy to confirm the status of peritoneal metastasis.
Study: NCT06046638

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclopofol
Description: Induction of anesthesia followed by continuous infusion through out surgery. The anesthetic drug regimen will be adjusted according to the changes of blood pressure.