TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04845542

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ReStoreD
Description: ReStoreD is a remotely-administered behavioral intervention in which couples coping with stroke learn and practice goal-setting, communication strategies, and positive psychology activities, such as expressing gratitude, finding meaning, and fostering connections. Participants are provided with 8 weekly modules, each featuring two components: 1) psychoeducational materials, such as an informational video and resources/links about a general topic related to resilience, coping, and/or overall well-being of the individual and couple, and 2) examples of positive psychology activities that relate to the week's theme or topic. Participants are asked to complete at least two positive psychology activities alone and two together each week.
Study: NCT05543759

Intervention type: DIETARY_SUPPLEMENT
Intervention: Ready-To-Use Therapeutic Food (RUTF)
Description: * SAM \[MUAC \<115mm or WHZ \<-3 or oedema (+/++)\] = Two 92g sachets RUTF/day (Approx. 1000 kcal/day).~* MAM \[MUAC 115mm\<125mm or WHZ \<-2\] = One 92g sachet RUTF/day (Approx. 500 kcal/day).
Study: NCT05061823

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bintrafusp alfa
Description: Participants who are continuing treatment with bintrafusp alfa and were previously assigned to a bintrafusp alfa dose based on body weight which is (i.e.) milligrams per kilogram (mg/kg) per dose in a parent protocol, will receive an intravenous infusion of bintrafusp alfa at the dose specified based upon the participant's parent protocol once every 2 week or, 2400 mg once every 3 weeks. Participants who are entering the rollover study after discontinuation of treatment in a parent study will receive bintrafusp alfa at a dose of either 1200 or 2400 mg once every 2 weeks or 2400 mg once every 3 weeks until confirmed disease progression, death, unacceptable toxicity or study withdrawal.
Study: NCT05228964

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Focused ultrasound
Description: Focused ultrasound at a 10 Hz pulse repetition frequency, 5% duty cycle, and 720 mw/cm squared de-rated spatial peak temporal average intensity, delivered over 10 min.
Study: NCT04683900

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard of care + Mediterranean diet (intervention)
Description: Participants will receive a constipation management handout that is distributed regularly to patients who present with constipation symptoms at an outpatient neurology clinic. The handout recommends increasing fluids daily, as well as increasing physical activity and dietary fiber intake. Laxative medications and recommendations for usage are included.~Participants will be instructed to include the following in their diet: a) abundant use of olive oil for cooking and dressing dishes; b) consume ≥2 daily servings of vegetables; c) ≥2-3 daily serving of fruits; d) ≥3 weekly servings of legumes; e) ≥3 weekly servings of fish/seafood; f) ≥3 weekly serving of nuts/seeds; g) select white instead of red or processed meats; h) cook at least twice a week with sofrito. Limit consumption of cream, butter, processed meat, sugared beverages, industrial bakery products and desserts, and French fries or chips. For usual drinkers, the main source of alcohol should be wine.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard of care (control)
Description: Participants will receive a constipation management handout that is distributed regularly to patients who present with constipation symptoms at an outpatient neurology clinic. The handout recommends increasing fluids daily, as well as increasing physical activity and dietary fiber intake. Laxative medications and recommendations for usage are included.
Study: NCT05621096

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Bridging radiation therapy
Description: Days -20 to -7: Patients will receive 2 fractions of 2 gray (Gy) for a total of 4 Gy received.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Liso-cel
Description: Day 0: Patients will receive an infusion of liso-cel CAR T-cell product.~Prior to the liso-cell infusion (Days -5 to -3), patients will receive lymphodepleting chemotherapy using fludarabine 30mg/m2 and cyclophosphamide 300mg/m2 per institutional standard procedures.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Post-infusion radiation
Description: Days 30 to 80: Patients eligible for post-infusion radiation will receive a total dose of up to 32 Gy.
Study: NCT05313477

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ergocalciferol Capsules
Description: Depend on initial 25(OH) vitamin D level If \<10ng/mL, 60000U of Ergocalciferol capsules per week If 10-19.9ng/mL, 40000U of Ergocalciferol capsules per week If \>20 ng/mL, 20000U of Ergocalciferol capsule per week

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Calcium carbonate
Description: 1000mg of Calcium carbonate daily
Study: NCT06564077

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Eldoa technique with conventional therapy
Description: is myofascial stretching technique of the cervical spine. Patients were asked to adopt desired position to target intervertebral segments. Breathing is also important factor in ELDOA stretch. Patients were instructed to not to hold or strain breathing through promoting diaphragmatic breathing.~* Hot pack for 20 minutes~* Strengthening exercises for deep neck flexors, rhomboids, serratus anterior, and lower trapezius (2 sets of 10 reps per day).~* Stretching exercise for pectoralis muscle (20 sec hold,5 reps)

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional therapy
Description: * Hot pack for 20 minutes~* Strengthening exercises for deep neck flexors, rhomboids, serratus anterior, and lower trapezius (2 sets of 10 reps per day).~* Stretching exercise for pectoralis muscle (20 sec hold,5 reps)
Study: NCT05145491

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Immediate Vitrectomy
Description: Surgery to remove epiretinal membrane (ERM). Vitrectomy will be performed on eyes within 1 month of randomization

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Deferred Vitrectomy
Description: Vitrectomy may be performed only if at least one of the following criteria is met:~1. Decrease in visual acuity ≥10 letters from baseline at a single visit presumed to be from ERM~2. Decrease in visual acuity ≥5 letters from baseline at two consecutive visits presumed to be from ERM~   a. Visits must be at least one month apart~3. Participant actively requests surgery due to worsening symptoms~4. Complication requires prompt surgical intervention (e.g., macular hole, retinal detachment, non-clearing vitreous hemorrhage)
Study: NCT06535607

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Volrustomig
Description: IV Infusion
Study: NCT05536440

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07261271
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV or SC
Study: NCT04580732

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: MiniStim PNS
Description: MiniStim PNS is indicated for pain management in adults who have severe intractable chronic pain of peripheral nerve origin.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: MiniStim PNS
Description: MiniStim PNS is indicated for pain management in adults who have severe intractable chronic pain of peripheral nerve origin.
Study: NCT05459974

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Colchicine 0.6 mg
Description: Colchicine 0.6 mg once daily for 30 days after the atrial fibrillation ablation

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo pill once daily for 30 days after the atrial fibrillation ablation
Study: NCT05886465

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atezolizumab
Description: 1200 mg, iv.drip, Q3W

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: 15mg/kg, iv.drip, Q3W

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: HAIC with FOLFOX
Description: administration of oxaliplatin , fluorouracil, and leucovorin via the tumor feeding arteries, Q3W
Study: NCT06162611

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Etonogestrel implant with Oral Levonorgestrel emergency contraception 1.5mg
Description: Single pill of oral levonorgestrel 1.5mg X 1 dose (e.g. Plan B) same day as contraceptive implant insertion

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Etonogestrel implant with oral placebo
Description: Single pill of placebo same day as contraceptive implant insertion
Study: NCT05776329

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: AIA-D
Description: The total energy contribution (1800 kcal/d) is 20% from protein, 25% from lipids, and 55% from carbohydrates. The recommendations include increasing protein intake primarily from plant sources, limiting the intake of red and processed meat, reducing refined sugar, and moderating dairy consumption. It also includes a list of locally produced and seasonal fruits and vegetables and a list of selected ingredients with anti-inflammatory properties to elaborate their foods. Participants will attend 3 motivational sessions of 1 h every two weeks. Besides nutrition and health, the motivational talks focused on the environmental impact of sustainability. Session 1: Planetary healthy diet. The inflammatory potential of diet. Explanation of the program. Session 2. Effect of ultra-processed food on health. Session 3. Healthy diets.~Follow-up information, recipes, and pictures of dishes that meet the given recommendations will be sent once a week through closed social media groups.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CONV-D
Description: CONV-D is based on general healthy diet recommendations. The total energy contribution (1800 kcal/d) was 20% from protein, 25% from lipids, and 55% from carbohydrates.~Among the recommended food groups are fruits (5 times a day), vegetables (5 times a day), cereals (3 times a day), legumes (3 times a day), dairy products (2 times a day), food of animal origin (3 times per day).~Participants in the CONV-D group will attend one motivational and nutritional orientation session on day 1 of the intervention.~Session 1. Food and nutrition. Obesity and diet. General healthy diet recommendations. Delivery of material (table of food equivalents).~Follow-up information will be sent once a week through closed social media groups.
Study: NCT06005116

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: [68Ga]-NOTA-SGC8
Description: Participants will be irrigated with \[68Ga\]-NOTA-SGC8 intravesically, with 0.05mCi/kg per person per time according to body weight, no more than 5mCi. The participants will be instructed to urinate cleanly before irrigation, and then irrigated \[68Ga\]-NOTA-SGC8 into the bladder via catheter for 30 minutes to make full contact between the injection and tumor. After 30 minutes, the injection will be withdrawn and 300ml normal saline will be injected into the bladder to maintain the shape of the bladder.
Study: NCT04809701

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Temporary implantation of defibrillation coils and pulse generator
Description: Each subject will undergo temporary implantation of defibrillation coils and pulse generator according to the NV-ICD electrode configurations.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Temporary implantation of defibrillation coils and pulse generator
Description: Each subject will undergo temporary implantation of defibrillation coils and pulse generator according to the NV-ICD electrode configurations.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Defibrillation following induction of VA (Configuration A first)
Description: Ventricular arrhythmia (VA) will be induced via an EP catheter placed in the right ventricle. After VA is confirmed, a defibrillation shock will be attempted to terminate the arrhythmia. Up to two defibrillation energies will be tested for Configuration A. Then up to two defibrillation energies will be tested for Configuration B.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Defibrillation following induction of VA (Configuration B first)
Description: Ventricular arrhythmia (VA) will be induced via an EP catheter placed in the right ventricle. After VA is confirmed, a defibrillation shock will be attempted to terminate the arrhythmia. Up to two defibrillation energies will be tested for Configuration B. Then up to two defibrillation energies will be tested for Configuration A.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Removal of defibrillation coils and pulse generator
Description: Defibrillation coils and pulse generator will be removed from the subject after the defibrillation tests are completed.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Removal of defibrillation coils and pulse generator
Description: Defibrillation coils and pulse generator will be removed from the subject after the defibrillation tests are completed.
Study: NCT06340191

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pilates with cueing
Description: The Pilates with a cueing component of the intervention involved a specialized approach to Pilates training. Participants in this group underwent an initial phase of training before the main sessions began, which consisted of two smaller group sessions focused on learning explicit verbal and tactile cues. These cues were designed to assist participants in maintaining proper body alignment, engaging specific muscle groups more effectively, and refining their movement techniques to enhance the overall efficacy of the Pilates exercises.~During the actual Pilates sessions, the instructors, who were certified and brought extensive experience to the program, provided real-time feedback to the participants. This feedback was based on the cueing instructions, aiming to optimize the execution of the Pilates exercises.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Pilates without cueing
Description: The Pilates without cueing portion of the study involved participants following the same comprehensive Pilates program as the Pilates with cueing group, with a significant distinction: they did not receive any additional training on cueing. This group engaged in 60-minute Pilates sessions twice a week for 8 weeks, under the supervision of certified and highly experienced Pilates instructors. The program included a variety of exercises, both mat-based and utilizing props, designed to improve participants\&#39; physical condition and wellness.~However, unlike their counterparts in the first group, these participants were not given explicit instructions on how to enhance their body alignment, muscle engagement, or movement techniques through verbal and tactile cues. They performed the Pilates exercises following the standard regimen, without the nuanced guidance and real-time feedback focused on optimizing exercise execution through cueing.
Study: NCT05584384

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Direct Current Stimulation
Description: Transcranial Direct Current Stimulation (tDCS) is a non-invasive neuromodulatory method utilizing weak electrical currents to elicit short and long-term central nervous system changes.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Sham Transcranial Direct Current Stimulation
Description: The sham was administered using the same tDCS devices as in the active group with a preprogrammed sham protocol of 20 minutes to be virtually indistinguishable from the active stimulation.
Study: NCT05369754

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: YBSW015 injection
Description: Prepared YBSW015 injection is intravenously injected by an infusion pump or gravity infusion with intravenous infusion of 250 mL for 60 min±10 min.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: YBSW015 injection
Description: Prepared YBSW015 injection is intravenously injected by an infusion pump or gravity infusion with intravenous infusion of 250 mL for 60 min±10 min.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: YBSW015 injection
Description: Prepared YBSW015 injection is intravenously injected by an infusion pump or gravity infusion with intravenous infusion of 250 mL for 60 min±10 min.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: YBSW015 injection
Description: Prepared YBSW015 injection is intravenously injected by an infusion pump or gravity infusion with intravenous infusion of 250 mL for 60 min±10 min.
Study: NCT05316324

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Prepectoral Breast Reconstruction with Acellular Dermal Matrix (ADM)
Description: Prepectoral Breast Reconstruction with (ADM)

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Prepectoral Breast Reconstruction without Acellular Dermal Matrix (ADM)
Description: Prepectoral Breast Reconstruction without ADM
Study: NCT05082077

Intervention type: DEVICE
Intervention: LIVERguard
Description: The LIVERguard is an FDA cleared and is a CE-marked medical device intended to be used for the static hypothermic preservation of livers during transportation and eventual transplantation into a recipient using cold storage solutions indicated for use with the liver. The intended organ storage time for the LIVERguard is up to 16 hours.
Study: NCT06076525

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Multidirectional Perturbations for Balance Control Assessment (60 perturbations)
Description: The intervention involves exposing participants to a series of 60 controlled multidirectional perturbations while walking on a treadmill. These perturbations are delivered in varying directions and magnitudes to simulate real-world conditions that might lead to a loss of balance, such as slips or trips. Participants will undergo this series during multiple experimental sessions referred to as epochs. The complete intervention consists of a treadmill familiarization period followed by 5 epochs to assess motor flexibility. Each epoch is followed by a rest period to ensure participant safety and minimize fatigue.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Multidirectional Perturbations for Balance Control Assessment (60 perturbations)
Description: The intervention involves exposing participants to a series of 60 controlled multidirectional perturbations while walking on a treadmill. These perturbations are delivered in varying directions and magnitudes to simulate real-world conditions that might lead to a loss of balance, such as slips or trips. Participants will undergo this series during multiple experimental sessions referred to as epochs. The complete intervention consists of a treadmill familiarization period followed by 5 epochs to assess motor flexibility. Each epoch is followed by a rest period to ensure participant safety and minimize fatigue.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Multidirectional Perturbations for Balance Control Assessment (60 perturbations)
Description: The intervention involves exposing participants to a series of 60 controlled multidirectional perturbations while walking on a treadmill. These perturbations are delivered in varying directions and magnitudes to simulate real-world conditions that might lead to a loss of balance, such as slips or trips. Participants will undergo this series during multiple experimental sessions referred to as epochs. The complete intervention consists of a treadmill familiarization period followed by 5 epochs to assess motor flexibility. Each epoch is followed by a rest period to ensure participant safety and minimize fatigue.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Multidirectional Perturbations for Balance Control Assessment (60 perturbations)
Description: The intervention involves exposing participants to a series of 60 controlled multidirectional perturbations while walking on a treadmill. These perturbations are delivered in varying directions and magnitudes to simulate real-world conditions that might lead to a loss of balance, such as slips or trips. Participants will undergo this series during multiple experimental sessions referred to as epochs. The complete intervention consists of a treadmill familiarization period followed by 5 epochs to assess motor flexibility. Each epoch is followed by a rest period to ensure participant safety and minimize fatigue.