Study: NCT06245434

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Repeated behavioural assessment
Description: One CRS-R per visit~* 4 SECONDs~* Eye tracking during every clinical assessment~* Recording every 2-4h of the Glasgow Coma Score~* Recording every 2h of the temperature and pupillometer reactivity to light

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Repeated behavioural assessment
Description: One CRS-R per visit~* 4 SECONDs~* Eye tracking during every clinical assessment~* Recording every 2-4h of the Glasgow Coma Score~* Recording every 2h of the temperature and pupillometer reactivity to light

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Repeated behavioural assessment
Description: One CRS-R per visit~* 4 SECONDs~* Eye tracking during every clinical assessment~* Recording every 2-4h of the Glasgow Coma Score~* Recording every 2h of the temperature and pupillometer reactivity to light

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Act-Pass paradigm
Description: Before and after sedation withdrawal Assessment of infra-clinical response to an active paradigm (attention focalisation or diversion).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Act-Pass paradigm
Description: Before and after sedation withdrawal Assessment of infra-clinical response to an active paradigm (attention focalisation or diversion).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Act-Pass paradigm
Description: Before and after sedation withdrawal Assessment of infra-clinical response to an active paradigm (attention focalisation or diversion).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Biological measures of circadian and monoamines biomarkers
Description: Systematic urinary sampling every 2 hours for melatonin, cortisol and monoamines metabolites

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Biological measures of circadian and monoamines biomarkers
Description: Systematic urinary sampling every 2 hours for melatonin, cortisol and monoamines metabolites

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Biological measures of circadian and monoamines biomarkers
Description: Systematic urinary sampling every 2 hours for melatonin, cortisol and monoamines metabolites

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Transcriptomic and genomic analysis
Description: Definition of the peripheral cellular clock by 2 transcriptomic measures Constitution of a genomic biobank to analyse the cofounding factors for circadian disruption and differential clinical recovery

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Transcriptomic and genomic analysis
Description: Definition of the peripheral cellular clock by 2 transcriptomic measures Constitution of a genomic biobank to analyse the cofounding factors for circadian disruption and differential clinical recovery

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Transcriptomic and genomic analysis
Description: Definition of the peripheral cellular clock by 2 transcriptomic measures Constitution of a genomic biobank to analyse the cofounding factors for circadian disruption and differential clinical recovery

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Polysomnography with concomitant environment recording
Description: One 48h polysomnography for the first visit~+ 3\* 24h polysomnography for each visit Synchronised recordings of light, sound, activity in patients' rooms

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Polysomnography with concomitant environment recording
Description: One 48h polysomnography for the first visit~+ 3\* 24h polysomnography for each visit Synchronised recordings of light, sound, activity in patients' rooms

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Polysomnography with concomitant environment recording
Description: One 48h polysomnography for the first visit~+ 3\* 24h polysomnography for each visit Synchronised recordings of light, sound, activity in patients' rooms

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Actimetry
Description: Continuous recording of movements at the wrist during 7 days after sedation withdrawal

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Actimetry
Description: Continuous recording of movements at the wrist during 7 days after sedation withdrawal

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Actimetry
Description: Continuous recording of movements at the wrist during 7 days after sedation withdrawal

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Morphological MRI
Description: Precise description of brain lesion by a 3T MRI within the 1st week after sedation withdrawal

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Morphological MRI
Description: Precise description of brain lesion by a 3T MRI within the 1st week after sedation withdrawal