TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06659731

Intervention type: OTHER
Intervention: Quantitative Sensory testing (QST)
Description: The QST protocol (Rolke et al., 2006; Blankenburg et al., 2010), implies the administration of 7 short sensory test in order to measure up to 13 parameters, which can be grouped as follows: thermal detection thresholds for the perception of cold, warm and paradoxical heat sensations, thermal pain thresholds for cold and hot stimuli, mechanical detection thresholds for touch and vibration, mechanical pain thresholds and sensitivity for pinprick and blunt pressure, vibration detection threshold and pressure pain threshold.

Intervention type: OTHER
Intervention: Quantitative Sensory testing (QST)
Description: The QST protocol (Rolke et al., 2006; Blankenburg et al., 2010), implies the administration of 7 short sensory test in order to measure up to 13 parameters, which can be grouped as follows: thermal detection thresholds for the perception of cold, warm and paradoxical heat sensations, thermal pain thresholds for cold and hot stimuli, mechanical detection thresholds for touch and vibration, mechanical pain thresholds and sensitivity for pinprick and blunt pressure, vibration detection threshold and pressure pain threshold.

Intervention type: OTHER
Intervention: EEG
Description: EEG recording at rest and while receiving heat stimuli to study cortical processing of salient thermal stimuli. Up to 30 painful thermal stimuli, will be delivered to the patients' hand dorsum in order to register contact heat evoked potentials (CHEPs).

Intervention type: OTHER
Intervention: EEG
Description: EEG recording at rest and while receiving heat stimuli to study cortical processing of salient thermal stimuli. Up to 30 painful thermal stimuli, will be delivered to the patients' hand dorsum in order to register contact heat evoked potentials (CHEPs).
Study: NCT06661538

Intervention type: BEHAVIORAL
Intervention: Food Security Screening & Referral Program
Description: The I-FRESH (Implementing Food Referrals for Equity and Sustained Health) program is the food security nutrition support program that involves some combination and form of: 1) screening and identification of families experiencing food insecurity; 2) discussions with families to determine readiness to engage with nutrition support programs and other community resources; 3) referrals and support to engage with a program; and 4) conducting follow-up assessments to determine fit of program, track utilization, and assess need for additional referrals. The exact implementation and workflow for this program will be optimized for each clinic.
Study: NCT04813406

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anlotinib + Sintilimab
Description: Anlotinib: 1 capsule (10mg) once a day, d1-d14 per cycle, 3 weeks for a treatment cycle.~Sintilimab: 200 mg/time, intravenous injection, every 3 weeks is one cycle.
Study: NCT05682950

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: online adaptive radiotherapy
Description: CTV covers pelvis.
Study: NCT06120855

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Regulated cannabis from authorized pharmacies
Description: The intervention group is allowed to purchase regulated cannabis in authorized pharmacies. The intervention includes various offers: Participants can choose between cannabis sorts and delivery methods, and they are encouraged to shift from smoking cannabis to vaping cannabis-containing e-liquids, vaporizing cannabis blossoms or using oral cannabis. Vaping / vaporizing electronic devices are also recommended. At the same time, pharmacists offer opportunistic smoking cessation and problematic cannabis, alcohol use and further drug use counseling that conforms to motivational interviewing principles.~Study participants can choose between different cannabis-containing products such as dried cannabis flowers, cannabis concentrates (colloquially called hashish or hash), e-liquids and oral cannabis. Besides the cannabis products, participants can buy vaping or vaporizing electronic devices at the pharmacy (they are not considered as study products).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cannabis from the illicit market
Description: The control group receives no intervention and is expected to continue purchasing cannabis from the illicit market.
Study: NCT04922242

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Welch Emotional Connection Screen for Neonatal Intensive Care Unit
Description: The Welch Emotional Connection Screen (WECS) is an investigational developmental screening tool, developed to rate the quality of the emotional connection that formed between mother and child. The screen is administered in 2-3 minutes by observing a mother and child interact, and requires the rater to critically assess 4 sub-domains of emotional connection. The NICU WECS is a clinical tool adapted for use with neonates in the NICU. Reliability of NICU staff WECS scoring will be calculated via intra-class correlations with key scores. The WECS is scored on intervals of 0.5, with a minimum of 1 (rarely--low level of connection) and maximum of 3 (mostly--high connection). Scores are used to determine the level of need for intervention.
Study: NCT04959786

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ivermectin,ribavirin ,nitazoxanide and zinc
Description: oral intake of the 3 drugs ivermectin ,ribavirin and nitazoxanide plus zinc
Study: NCT06482138

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Biopsy and Cytobrush
Description: Collection of olfactory cleft biopsies and cytobrushes

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Biopsy and Cytobrush
Description: Collection of olfactory cleft biopsies and cytobrushes
Study: NCT05786976

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lotion BNO 3732
Description: Crem body lotion twice daily

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Body Lotion Benchmark product
Description: Crem body lotion twice daily
Study: NCT06661538

Intervention type: BEHAVIORAL
Intervention: Food Security Screening & Referral Program
Description: The I-FRESH (Implementing Food Referrals for Equity and Sustained Health) program is the food security nutrition support program that involves some combination and form of: 1) screening and identification of families experiencing food insecurity; 2) discussions with families to determine readiness to engage with nutrition support programs and other community resources; 3) referrals and support to engage with a program; and 4) conducting follow-up assessments to determine fit of program, track utilization, and assess need for additional referrals. The exact implementation and workflow for this program will be optimized for each clinic.

Intervention type: BEHAVIORAL
Intervention: Food Security Screening & Referral Program
Description: The I-FRESH (Implementing Food Referrals for Equity and Sustained Health) program is the food security nutrition support program that involves some combination and form of: 1) screening and identification of families experiencing food insecurity; 2) discussions with families to determine readiness to engage with nutrition support programs and other community resources; 3) referrals and support to engage with a program; and 4) conducting follow-up assessments to determine fit of program, track utilization, and assess need for additional referrals. The exact implementation and workflow for this program will be optimized for each clinic.

Intervention type: BEHAVIORAL
Intervention: Food Security Screening & Referral Program
Description: The I-FRESH (Implementing Food Referrals for Equity and Sustained Health) program is the food security nutrition support program that involves some combination and form of: 1) screening and identification of families experiencing food insecurity; 2) discussions with families to determine readiness to engage with nutrition support programs and other community resources; 3) referrals and support to engage with a program; and 4) conducting follow-up assessments to determine fit of program, track utilization, and assess need for additional referrals. The exact implementation and workflow for this program will be optimized for each clinic.
Study: NCT06661720

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Pembrolizumab
Description: Given intravenously

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Given intravenously

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tivozanib
Description: Given orally

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: MRI
Description: Undergo MRI

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: MRI
Description: Undergo MRI

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Computed Tomography
Description: Undergo CT scan

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT scan

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Biopsy
Description: Undergo biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: Undergo biopsy

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Questionnaire Administration
Description: Ancillary studies

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaire Administration
Description: Ancillary studies
Study: NCT06661382

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Infiltrative treatment with CB-PRP
Description: Injection of CB-PRP or placebo into the vulvar site. Three treatments are planned four weeks apart. Three and six months after the last treatment with CB-PRP/ placebo each participant will be re-evaluated by vulvoscopy and biopsy, and will be given validated questionnaires to assess satisfaction, symptoms, and quality of life, psychological state, and sexual function.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Infiltrative treatment with CB-PRP
Description: Injection of CB-PRP or placebo into the vulvar site. Three treatments are planned four weeks apart. Three and six months after the last treatment with CB-PRP/ placebo each participant will be re-evaluated by vulvoscopy and biopsy, and will be given validated questionnaires to assess satisfaction, symptoms, and quality of life, psychological state, and sexual function.
Study: NCT06659081

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: socket shield technique
Description: partial extraction therapy : sectioning the root and keeping part of it in contact with labial plate of bone

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: subepithelial connective tissue graft
Description: A connective tissue graft harvesting from maxillary tuberosity area

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: subepithelial connective tissue graft
Description: A connective tissue graft harvesting from maxillary tuberosity area

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: implant placement
Description: implant placement

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: implant placement
Description: implant placement
Study: NCT06662214

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Refined maize flour
Description: Meal made form refined maize flour

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Whole grain flour
Description: Meal made form whole grain maize flour
Study: NCT05422534

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: CoQ10
Description: Participants will receive 1800 mg/day for 12 weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: CoQ10
Description: Participants will receive 1800 mg/day for 12 weeks

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants will receive placebo or CoQ10/day for 12 weeks

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants will receive placebo or CoQ10/day for 12 weeks

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: HB-HIIT
Description: Participants will be performed on non dialysis days. It will be video supervised exercise sessions with self directed exercises using pre-recorded bodyweight and strength exercise videos.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: HB-HIIT
Description: Participants will be performed on non dialysis days. It will be video supervised exercise sessions with self directed exercises using pre-recorded bodyweight and strength exercise videos.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Observational
Description: Participant regular activities

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Observational
Description: Participant regular activities
Study: NCT06661005

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nitrous oxide
Description: The Nitrous oxide group will receive instructions to arrive at clinic 30 minutes before her procedure in order to sign consent forms. She will not be given instructions to remain NPO and will not be required to have someone bring her to and from the appointment. No IV will be placed. Anesthesia induction will be done by an anesthesiologist with a nitrous oxygen mixture at a 70:30 ratio

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV Sedation
Description: Anesthesia induction will be done by an anesthesiologist with propofol per standard protocol. A pulse oximeter will be placed and oxygen will be administered through a nasal cannula and the patient will be instructed to breath.
Study: NCT06658145

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Vnotes surgery using fully visualised surgical instruments
Description: Vnotes surgery using fully visualised surgical instruments

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Vnotes surgery using traditional surgical instruments
Description: Vnotes surgery using traditional surgical instruments
Study: NCT06542978

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: 40Hz stimulation
Description: Exogenous 40HZ stimulation is a physical intervention that can drive oscillations in the gamma range, and the oscillations and pulses caused at the corresponding frequency can lead to a significant reduction in β-amyloid, reverse tau hyperphosphorylation, and thereby improve the cognitive function of patients.
Study: NCT05041907

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nirmatrelvir/ritonavir (e.g. PAXLOVID™)
Description: Nirmatrelvir 300mg BD for 5/7 Ritonavir 100mg BD for 5/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nitazoxanide
Description: Nitazoxanide 1.5g BD 7/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Molnupiravir and nirmatrelvir/ritonavir (e.g. PAXLOVID™)
Description: Molnupiravir 800mg BD for 5/7, Nirmatrelvir 300mg BD for 5/7, Ritonavir 100mg BD for 5/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydroxychloroquine
Description: Hydroxychloroquine 400mg D0 BD and 400MG OD for a further 6/7

Intervention type: OTHER
Group type: OTHER
Intervention: No treatment
Description: No treatment (except antipyretics- paracetamol)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Monoclonal antibodies
Description: Monoclonal antibodies: 300mg tixagevimab/ 300 mg cilgavimab given once on D0

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluoxetine
Description: Fluoxetine 40mg OD for 7/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Molnupiravir
Description: Molnupiravir 800mg BD for 5/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sotrovimab
Description: Sotrovimab 500mg given once on D0

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ensitrelvir
Description: Ensitrelvir 375mg OD D0 and 125mg OD for a further 4/7

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Monoclonal antibodies
Description: Monoclonal antibodies: 600mg casirivimab/ 600mg imdevimab given once on D0

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Favipiravir
Description: Favipiravir 1800mg BD D0 and 800mg BD for a further 6/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ivermectin
Description: Ivermectin 600micrograms/kg/day for 7/7.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Remdesivir
Description: Remdesivir 200mg D0 and 100mg for a further 4/7.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atilotrelvir/ritonavir
Description: Atilotrelvir 150mg BD for 5/7 Ritonavir 100mg BD for 5/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: Metformin 500mg TDS 5/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nirmatrelvir/ritonavir
Description: Nirmatrelvir 300mg BD for 5/7 Ritonavir 50mg BD for 5/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nirmatrelvir/ritonavir
Description: Nirmatrelvir 150mg BD for 5/7 Ritonavir 50mg BD for 5/7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nirmatrelvir
Description: Nirmatrelvir 300mg BD for 5/7
Study: NCT06657950

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Integrative hatha yoga and mindful self-compassion
Description: 12 weeks of integrative hatha yoga and mindful self-compassion training
Study: NCT06615661

Intervention type: DEVICE
Intervention: C-Rex Instrument
Description: The C-Rex Instrument is a manual ophthalmic surgical instrument used for ab interno goniotomy and inner wall trabeculotomy.

Intervention type: DEVICE
Intervention: C-Rex Instrument
Description: The C-Rex Instrument is a manual ophthalmic surgical instrument used for ab interno goniotomy and inner wall trabeculotomy.
Study: NCT05396222

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: 3D-printed custom-made non-rigid biomimetic implant
Description: We developed a 3D printed, custom-made, biomimetic prosthesis, with non-rigid structure, which has been tested in biomechanical study and porcine model, showing good bone formation and less stiffness as well. Therefore, we proposed a prospective clinical study to investigate safety, subsidence, and fusion of this prosthesis.
Study: NCT04922242

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: NICU WECS Training
Description: WECS Training is an educational module consisting of an introduction of the concepts of emotional connection and autonomic co-regulation as studied by The Nurture Science Program, as well as an illustration of how these experiential constructs differ from traditional care plans that focus on educating parents to encourage bonding as opposed to autonomic emotional connection within the NICU. An introduction to the domains of the WECS screen as well as illustrations of these domains through video will augment the training designed for NICU staff.
Study: NCT03432936

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MRI guided procedure software evaluation
Description: MRI guided ablation/biopsy using standard MR imaging along with Philips Interventional iSuite software tools.
Study: NCT06648395

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CBT Text Messages
Description: CBT text messages will be sent 3 times per week for 4 weeks

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Supportive Messages
Description: Supportive text messages will be sent 3 times per week for 4 weeks
Study: NCT05779761

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online, Self-Directed Attention Skills Training with Coaching Support
Description: The initial set of modules focus on psychoeducation about distress, the impact that cognitions/behaviors/emotions have on recent situations, and self-monitoring of worry/rumination/self-criticism. The next set of modules focus on the development of attention skills that help regulate one's emotional experience (i.e., recognizing emotions when they are happening, identifying the meaning of a given emotion experience, soothing oneself in the context of negative emotional experiences). All modules will be online and self-directed. An internet-based online platform will be used to promote engagement with and increase accessibility to between-session skills practice and treatment-related activities (e.g., self-monitoring, worksheets). Brief, weekly coaching support (from a trained, masters-level student) will be provided to promote engagement and to help clarify concepts.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online, Self-Directed Attention & Reflective Thought Skills Training with Coaching Support
Description: The initial set of modules focus on psychoeducation about distress, the impact that cognitions/behaviors/emotions have on recent situations, and self-monitoring of worry/rumination/self-criticism. The next set of modules focus on the development of attention and reflective thinking skills that help regulate one's emotional experience (i.e., recognizing emotions when they are happening, identifying the meaning of a given emotion experience, soothing oneself in the context of negative emotional experiences). All modules will be online and self-directed. An internet-based online platform will be used to promote engagement with and increase accessibility to between-session skills practice and treatment-related activities (e.g., self-monitoring, worksheets). Brief, weekly coaching support (from a trained, masters-level student) will be provided to promote engagement and to help clarify concepts.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online, Self-Directed Health & Wellness Education Training with Coaching Support
Description: The initial set of modules focus on psychoeducation about stress, the impact that stress has on one's life, and self-monitoring of stress. The next set of modules focus on sleep, time management, nutrition, and exercise. All modules will be online and self-directed. An internet-based online platform will be used to promote engagement with and increase accessibility to between-session skills practice and treatment-related activities (e.g., self-monitoring, worksheets). Brief, weekly coaching support (from a trained, masters-level student) will be provided to promote engagement and to help clarify concepts.
Study: NCT06319430

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: robots
Description: LEGO robots with adaptation according to child's age and developmental skills.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional
Description: A pack of conventional play tools consists of dolls, teddy bears, miniature wild animals, and small cars. All are available, and the child can choose to play with them.
Study: NCT04953377

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PFMT educational intervention
Description: an educational intervention to learn about the pelvic floor and how to train it
Study: NCT06500234

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Megestrol Acetate and olanzapine
Description: megestrol acetate, 160 mg, oral everyday; olanzapine 2.5 mg, oral everyday

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Starch powder 50 mg
Description: Starch powder 50 mg, oral, everyday