TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04965597

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Aspiration
Description: Undergo bone marrow biopsy and aspiration

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: X-Ray Imaging
Description: Undergo chest x-ray

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo chest CT
Study: NCT05647395

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tracheal tube cuffs differ in deflation
Description: When removing the endotracheal tube, the gas in the cuff is drawn at a uniform and slow pace
Study: NCT06067191

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RV299
Description: Oral Suspension

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: matching placebo
Study: NCT05925478

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ptergyopalatine Fossa Block
Description: Injection of local anesthetic (e.g. Bupivacaine) into the pterygopalatine fossa to treat headache related to aneurysmal subarachnoid hemorrhage

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine 0.25% Injectable Solution
Description: Injection of local anesthetic (e.g. Bupivacaine) into the pterygopalatine fossa to treat headache related to aneurysmal subarachnoid hemorrhage
Study: NCT06566092

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LN-145/LN-144
Description: A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LN-145/LN-144
Description: A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LN-145/LN-144
Description: A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LN-145/LN-144
Description: A tumor sample is resected from each patient and cultured ex vivo to expand the population of tumor infiltrating lymphocytes.
Study: NCT05455593

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Water aerobics
Description: 1-hour session of water aerobics per week, for 3 months. A specialized trainer will carry out water aerobics sessions and will focus on motor coordination, strength and cardiovascular workout.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Metacognitive Training (MCT)
Description: 1-hour session of MCT per week, for 3 months. A trained psychologist will carry out the MCT sessions. MCT addresses the most common cognitive biases in psychosis. Each session will focus on one topic, such as attributional style, jumping to conclusions, theory of mind, emotion recognition, memory or empathy.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Combined intervention
Description: Patients in this arm will participate in both in water aerobics and MCT sessions, once a week for each intervention.
Study: NCT05858515

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib 4 MG
Description: Nonproprietary name: Baricitinib

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06340750

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: LMY-920
Description: CAR T Therapy
Study: NCT04938102

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Botulinum Toxin Type A Injection [Botox]
Description: Injection of 100 units of botulinum toxin into the lower esophageal sphincter (25 units in each quadrant).
Study: NCT05117294

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bocidelpar
Description: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bocidelpar
Description: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bocidelpar
Description: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bocidelpar
Description: Oral
Study: NCT05611866

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Fecal Microbiota Transplantation
Description: FMT at Week 0
Study: NCT05289505

Intervention type: DEVICE
Intervention: MUSIC-CARE
Description: This device allows the listening of music using different sequences of instrumental music created specifically, and using principles based on hypno-analgesia, that is to say the association of hypnotic techniques and approaches to help or analgesic, medicated or not. It consists of a tablet application containing instrumental music pieces, specially created and recorded for Music-Care. Each piece is at least 20 minutes long. The music can be played through headphones or speakers.
Study: NCT05092789

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesio taping group
Description: Participants in this group will receive treatment through standardised therapeutic kinesio taping along with conventional therapy.~Tape will place over the posterior cervical extensor muscle, from insertion to the origin, with the patient's neck in cervical contralateral side-bending and rotation.~Duration of kinesio tape will be of 48 hours with 50-100% tension.~Participants of this group will also receive conventional therapy which will include:~Hot pack for 10 minutes Stretching exercises of the neck muscles. This protocol is for 6 weeks. The sessions will be given twice a week making it a total of 12 sessions.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cervical thrust manipulation group
Description: Participants of this group will receive treatment via cervical thrust manipulation along with conventional therapy.~For mid cervical spine thrust manipulation, the patient will be in supine lying position,with cervical spine in neutral position.~The therapist will cradle the patients head with the other hand. Gentle ipsilateral cervical side flexion and contralateral rotation will introduce until tension will perceive in target tissues at contact point. A high velocity, low amplitude thrust manipulation, will direct upward and medially in direction of subject's contralateral eye.~Participants of this group will also receive conventional therapy which will include:~Hot pack for 10 minutes Stretching exercises of the neck muscles. This intervention protocol is for 6 weeks. The sessions will be given twice a week making it a total of 12 sessions with 1 month follow up.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional therapy group
Description: Participants of this group will receive only conventional therapy which will include:~Hot pack for 10 minutes Stretching Exercises of neck muscles. For sternocleidomastoid stretching, the subject will ask to sit or stand facing forward, exhale and slowly turn your head to right, by keeping shoulder relaxed and down,inhale and return to the center, then turn to look at your left shoulder, ask to hold this position for 30 seconds and do 3 repetitions.~For Trapezius stretching, patient is seated upright, therapist then passively move right ear to right shoulder.~This study includes interventional protocol of 6 weeks. The session will be given twice a week making it a total of 12 sessions with 1 month follow up.
Study: NCT05862623

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AER-01
Description: AER-01 solution for inhalation delivered via nebulizer

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo for solution for inhalation delivered via nebulizer
Study: NCT05933018

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: liver elastography
Description: the imaging of the liver will perform in the fasting state, in the morning hours by one specialist, dedicated to this procedure,
Study: NCT05662371

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Nociception Level monitor (NOL)
Description: NOL technology uses a multiparameter-based sensor platform, and advanced algorithm, to continuously monitor Autonomic Nervous System (ANS) functions. NOL reflects a patient's nociceptive state and analgesic effect, helping to optimize the administration of systemic and/or regional analgesics, and avoiding overdose or underuse of these drugs. The nociception level is a multiparameter monitor that combines information from the finger photoplethysmogram amplitude, skin conductance, skin conductance fluctuation, heart rate, heart rate variability, and their time derivatives into one index ranging from 0 (absence of noxious stimulation) to 100 (severe noxious stimulation).

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Standard care
Description: Hemodynamic changes outside of the normal range i.e., hypertension (systolic blood pressure greater than 140 mm Hg), tachycardia (heart rate greater than 90 min-1) and hypotension (mean arterial pressure less than 60 mm Hg) will be first assessed using the guidance of Bispectral index and Train of four monitors. Sufentanil in doses of 2.5 to 5 mcg (maximum of 0.6-1.2 mic/kg for the entire surgery) is administered if the Bispectral index and Train of four monitor values are within normal range and if required vasopressor infusion is used. Vasoconstrictors may be given as a continuous infusion of norepinephrine, or bolus doses of ephedrine or phenylephrine. Only when blood pressure remains, low additional crystalloids will be given. Finally, in case of bradycardia (heart rate less than 30 min-1), atropine may be given
Study: NCT05059613

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: probiotics
Description: one times a day during the whole treatment
Study: NCT04760899

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transcranial Direct Current Stimulation
Description: Transcranial Direct Current Stimulation is a form of non-invasive brain stimulation. It uses small electrodes to deliver small amounts of current to specific areas of the brain to either increase or decrease excitability.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcranial Direct Current Stimulation
Description: Transcranial Direct Current Stimulation is a form of non-invasive brain stimulation. It uses small electrodes to deliver small amounts of current to specific areas of the brain to either increase or decrease excitability.
Study: NCT05011838

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 1. Health Services Redesign
Description: 1.1. Healthy Hearts service: a nursing station providing blood pressure measurement, cardiovascular risk assessment, preventive counselling and effective follow-up in extended opening hours.~1.2. Hypertension screening: All adults attending health care facilities who did not have their blood pressure measured in the previous year will be referred to the Healthy Hearts Service for screening.~1.3. Clinical management: 1.3.1. Creation of the cardiovascular risk team: a group of doctors supervising hypertension management and coordinating improvement.~1.3.2. Guideline-based standardized diagnostic and treatment protocols: a simplified diagnostic and treatment algorithm will identify a core set of primary and secondary antihypertensive medications.~1.3.3. Availability of antihypertensive medications: it will be assured through procurement mechanisms and its availability will be communicated to clinicians at the beginning of each week and ad hoc in case of stock-outs.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 2. Clinical Staff Training
Description: 2.1. Training on good clinical management of hypertension: focused on correct blood pressure measurement, use of evidence-based guidelines, cardiovascular risk assessment, use of a standardized diagnostic and treatment algorithm, correct prescription of pharmacological and non-pharmacological treatment, patient counselling, and how to tackle clinical inertia.~2.2. Training on communication skills and patients' needs assessment for all health workers involved in hypertension care. This training will be designed under the patient-centred medicine framework, aiming at equipping health providers with tools for understanding patients' feelings and experience of illness, and to improve their capacity to address social, psychological, and behavioural dimensions of hypertension care.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 3. Patient and Community Engagement
Description: 3.1. Patient empowerment: expert hypertensive patients , under the supervision of a social worker, will provide support and transmit their know-how to other patients in need, particularly those newly diagnosed or non-adherent to treatment or presenting uncontrolled hypertension.~3.2. Community engagement: a Community Hypertension Outreach Group will be set up, composed of existing voluntary community health workers, who will be trained and certified. This group will conduct blood pressure measurements in selected public areas of the commune, referring those with positive screening to the nearest health facility for diagnosis confirmation. It will also provide health information with emphasis on healthy lifestyles. Existing local communication channels such as the community radio and the local newspaper will be engaged.
Study: NCT06114576

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Orange juice enriched with vitamin D3 and encapsulated probiotics
Description: 25 high cardiometabolic risk volunteers will be asked to consume 250 ml orange juice enriched with 2000 IU vitamin D3 and 10\^8 cfu/ml encapsulated probiotics (Lactocaseibacillus casei shirota and Lactocaseibacillus rhamnosus GG) daily, for 8 weeks, without any other change in their dietary habits and physical activity.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional orange juice
Description: 25 high cardiometabolic risk volunteers will be asked to consume 250 ml conventional orange juice daily, for 8 weeks, without any other change in their dietary habits and physical activity.
Study: NCT06580041

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pramipexole
Description: CAU plan modified to include a trial of pramipexole.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methylphenidate
Description: CAU plan modified to include a trial of methylphenidate (or, if contraindicated: guanfacine).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phenelzine
Description: CAU plan modified to include a trial of phenelzine (or, if contraindicated: brexpiprazole).
Study: NCT04744025

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Microfluidics chamber
Description: Unwashed sperm will be placed into the inlet chamber of the microfluidics device. The most motile sperm will swim to the outlet chamber, and these sperms will be used for intracytoplasmic sperm injection (ICSI) into the eggs.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Density Gradient Centrifugation
Description: Sperm will be washed and centrifuged according to standard protocol, and these washed sperm will be used for ICSI.
Study: NCT05993364

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Free Aspire with Expiratory Flow Accelerator (EFA) technology
Description: Treatment sessions during which the EFA technology is used. Depending on the patient's clinical conditions, an oxygen additional support can be provided, while using the device. If present, during the sessions the tracheal cannula must be cuffed. Tracheal cannula aspiration must be provided when necessary. Sessions take place three times a day and take 20 minutes each time, from Monday to Saturday.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: In-Exufflator Machine
Description: Sessions using the In-Exufflator machine to improve the cough function, when the oxygen saturation decreases and the bronchial secretions increases.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: In-Exufflator Machine
Description: Sessions using the In-Exufflator machine to improve the cough function, when the oxygen saturation decreases and the bronchial secretions increases.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional respiratory treatment
Description: Standard rehabilitative treatment to improve the secretions management, that includes:~* A change of the patient posture every three hours;~* Airways humidification depending on the secretions features;~* Aspiration in the tracheal cannula whenever necessary.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Traditional respiratory treatment
Description: Standard rehabilitative treatment to improve the secretions management, that includes:~* A change of the patient posture every three hours;~* Airways humidification depending on the secretions features;~* Aspiration in the tracheal cannula whenever necessary.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional swallowing treatment
Description: Traditional rehabilitative treatment carried out by the speech and language pathologist in order to:~* Obtain decannulation (when a tracheal cannula is applied) following the Bargellesi Protocol steps;~* Improve oral structures strength and motility;~* Improve oral and perioral sensitivity with thermal or gustative or tactile stimulations;~* Improve the swallowing function with food trials of different consistencies, volume and temperature;~* Improve swallow efficacy and safety through the prescription of compensatory postures;

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Traditional swallowing treatment
Description: Traditional rehabilitative treatment carried out by the speech and language pathologist in order to:~* Obtain decannulation (when a tracheal cannula is applied) following the Bargellesi Protocol steps;~* Improve oral structures strength and motility;~* Improve oral and perioral sensitivity with thermal or gustative or tactile stimulations;~* Improve the swallowing function with food trials of different consistencies, volume and temperature;~* Improve swallow efficacy and safety through the prescription of compensatory postures;
Study: NCT06580041

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-based Stress Sensitivity Therapy (MBSST)
Description: CAU plan modified to include a trial of MBSST. MBSST is an individual psychotherapy delivered approximately weekly for 16 sessions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Complicated Grief Treatment (CGT)
Description: CAU plan modified to include a trial of CGT.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Care as usual (CAU) plan
Description: Unmodified CAU plan.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Care as usual (CAU) plan
Description: Unmodified CAU plan.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Care as usual (CAU) plan
Description: Unmodified CAU plan.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Care as usual (CAU) plan
Description: Unmodified CAU plan.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Care as usual (CAU) plan
Description: Unmodified CAU plan.
Study: NCT06475105

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oral Acetazolamide
Description: Participants will be randomized into group receiving either oral acetazolamide or placebo for up to 3 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants will be randomized into group receiving either oral acetazolamide or placebo for up to 3 days
Study: NCT06464484

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotics (Lactobacillus rhamnosus GG (ATCC 53103)
Description: Already mentioned in arm/group descriptions
Study: NCT04815070

Intervention type: PROCEDURE
Intervention: Ultrasonic measurement of antral area
Description: Ultrasound exam is done before the induction of spinal anesthesia. Three consecutive measurements of the anteroposterior (AP) and cranio-caudal (CC) diameters are performed.~The cross-sectional area (CSA) of antrum is shown by the following formula: CSA = AP x CC x ㅠ/4.~Antral area will correspond to the average of the three measures.

Intervention type: PROCEDURE
Intervention: Ultrasonic measurement of antral area
Description: Ultrasound exam is done before the induction of spinal anesthesia. Three consecutive measurements of the anteroposterior (AP) and cranio-caudal (CC) diameters are performed.~The cross-sectional area (CSA) of antrum is shown by the following formula: CSA = AP x CC x ㅠ/4.~Antral area will correspond to the average of the three measures.
Study: NCT05425550

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: medidux™ app
Description: Use of the regular medidux™ application for 12 (maximum 16) weeks
Study: NCT05684874

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Neoadjuvant RT
Description: Dosimetric CT scan with contrast injection for treatment planning. Radiation therapy at a dose of 50Gy in 25 fractions, 5 fractions per week. Daily pre-treatment positioning tomographic imaging (either high energy (MVCT) or cone beam computed tomography (CBCT)).~Delineation of the tumor volume and evaluation of its evolution. In case of change of volume and if medically relevant, new dosimetric scan and collection of the tumor volume.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pre-radiotherapy mpMRI
Description: Performed less than 14 days before the dosimetric scan. Conventional morphological T1-weighted, T2-weighted, and T1-weighted imaging sequences after injection of contrast agent.~Quantitative imaging sequences including multiple b-value diffusion imaging. Chemical shift sensitized sequences.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Post-radiotherapy mpMRI
Description: Performed 4 to 6 weeks after the end of the radiotherapy. Conventional morphological T1-weighted, T2-weighted, and T1-weighted imaging sequences after injection of contrast agent.~Quantitative imaging sequences including multiple b-value diffusion imaging. Chemical shift sensitized sequences.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tumor resection
Description: Performed 6 to 8 weeks after the end of radiotherapy. An anatomopathological observation of the surgical specimen will be performed.
Study: NCT04711993

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aerobic exercise
Description: Patients will do aerobic exercise three days a week for 40 minutes during 8 weeks. Aerobic exercise protocol will consist of warm up, loading and cooling periods. . Exercise prescription will be prepared in line with the recommendations of The American College of Sports Medicine.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Stretchin exercise
Description: Patients will do stretching exercise three days a week for 40 minutes during 8 weeks. Stretching exercises will start with active warm-up activities. Static stretching method will be used.
Study: NCT06187129

Intervention type: DEVICE
Intervention: nerve ultrasound
Description: nerve ultrasound

Intervention type: DEVICE
Intervention: nerve ultrasound
Description: nerve ultrasound