TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06259552

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SPX- 303 Injection, a bispecific anti-LILRB2 / anti-PD-L1 Antibody
Description: SPX- 303 Injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SPX- 303 Injection, a bispecific anti-LILRB2 / anti-PD-L1 Antibody
Description: SPX- 303 Injection
Study: NCT05462886

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Masimo INVSENSOR00057
Description: Noninvasive wearable health monitoring device
Study: NCT06543719

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Simulated work in the heat
Description: Participants perform a continuous heavy-intensity work bout (metabolic rate of \~260 W/m2) until core temperature reaches 38.0°C (equivalent to a 1°C increase in body core temperature above resting levels), which is immediately followed by intermittent work using a 1:1 work-rest allocation, starting with a 30 min rest break followed by a 30 min work bout for a total work duration of \~240 min. The work protocol is performed in the morning of day 1, and repeated in a post-lunch work period (i.e., afternoon of day 1) and on the morning of the next day (i.e., morning of day 2).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Simulated work in the heat
Description: Participants perform a continuous heavy-intensity work bout (metabolic rate of \~260 W/m2) until core temperature reaches 38.0°C (equivalent to a 1°C increase in body core temperature above resting levels), which is immediately followed by intermittent work using a 1:1 work-rest allocation, starting with a 30 min rest break followed by a 30 min work bout for a total work duration of \~240 min. The work protocol is performed in the morning of day 1, and repeated in a post-lunch work period (i.e., afternoon of day 1) and on the morning of the next day (i.e., morning of day 2).
Study: NCT06577285

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: zinc gluconate 50 mg with phytase supplement 176mg (800FTU)
Description: zinc gluconate 50 mg1 per day with phytase supplement 176mg (800FTU) (Goodphyte company) 2 tablets per day

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: zinc gluconate 50 mg
Description: zinc gluconate 50 mg 1 per day, 4 days before botulinum toxin injections.
Study: NCT05427604

Intervention type: OTHER
Group type: OTHER
Intervention: Olive oil
Description: ingestion of olive oil (3g) and blood measurement at baseline, after 1h, 2h, 3h, 4h, 5h, 6h

Intervention type: OTHER
Group type: OTHER
Intervention: Olive Oil
Description: ingestion of olive oil (3g) and blood sampling at the fatty acids pic concentration (for in vitro study)

Intervention type: OTHER
Group type: OTHER
Intervention: DHA oil
Description: ingestion of DHA oil (3g) and blood measurement at baseline, after 1h, 2h, 3h, 4h, 5h, 6h

Intervention type: OTHER
Group type: OTHER
Intervention: DHA oil
Description: ingestion of DHA oil (3g) and blood sampling at the fatty acids pic concentration (for in vitro study)
Study: NCT05901987

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: GC101
Description: Self-complementary AAV9 carrying a codon-optimized SMN coding sequence(coSMN1) driven by CMV enhancer and chicken β-actin promoter

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: GC101
Description: Self-complementary AAV9 carrying a codon-optimized SMN coding sequence(coSMN1) driven by CMV enhancer and chicken β-actin promoter

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: GC101
Description: Self-complementary AAV9 carrying a codon-optimized SMN coding sequence(coSMN1) driven by CMV enhancer and chicken β-actin promoter
Study: NCT05563129

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: First aid lessons
Description: The school children will have first aid training
Study: NCT06308848

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Microbiota-Directed Food
Description: MDF is a microbiota directed food for malnourished children aged 6 months and above. It is in sachet form. The sachet contains 92 gm of supplements and provides approximately 506 kcal.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Ready-to-Use Therapeutic Food
Description: RUTF is standard ready-to-use therapeutic food for SAM children aged 6 months and above.
Study: NCT05670873

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial magnetic stimulation
Description: Transcranial magnetic stimulation given to the left dorsolateral prefrontal cortex

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial magnetic stimulation
Description: Transcranial magnetic stimulation given to the left dorsolateral prefrontal cortex
Study: NCT05810454

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: iPACES (interactive Physical and Cognitive Exercise System)
Description: iPACES involves a pedal-to-play neuro-exergame in which physical and mental exercise are combined in an interactive way. In this condition a person will pedal to control forward motion in a tablet-based game, such as when pedaling along a virtual path and steering to different assigned errand locations.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: PACE (Physical and Cognitive Exercise)
Description: PACE involves a pedal-while-play experience in which physical and mental exercise are combined in a simultaneous, but not fully interactive way. In this condition a person will pedal while also separately steering in a tablet-based game, such as when pedaling while automatically progressing along a virtual path to different assigned errand locations.
Study: NCT06446544

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: VPFE monitoring with intraoperative alveolar recruitment maneuvers.
Description: VPFE monitoring with intraoperative alveolar recruitment maneuvers.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: VPFE monitoring with intraoperative alveolar recruitment maneuvers.
Description: VPFE monitoring with intraoperative alveolar recruitment maneuvers.
Study: NCT05748223

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mindfulness Meditation
Description: Mindfulness meditation has been reported to produce beneficial effects on a number of psychiatric, functional somatic, and stress-related symptoms and has therefore increasingly been incorporated into psychotherapeutic programs
Study: NCT04092361

Intervention type: DEVICE
Intervention: optical coherence tomography
Description: It generates cross sectional images by analyzing the time delay and magnitude change of low coherence light as it is backscattered by ocular tissues. An infrared scanning beam is split into a sample arm and a reference arm. As the sample beam returns to the instrument it is correlated with the reference arm in order to determine distance and signal change via photodetector measurement. The resulting change in signal amplitude allows tissue differentiation by analysis of the reflective properties, which are matched to a false color scale. As the scanning beam moves across tissue, the sequential longitudinal signals, or A-scans, can be reassembled into a transverse scan yielding cross-sectional images, or B-scans, of the subject. The scans can then be analyzed in a variety of ways providing both empirical measurements (e.g. RNFL or retinal thickness/volume) and qualitative morphological information.

Intervention type: DEVICE
Intervention: optical coherence tomography
Description: It generates cross sectional images by analyzing the time delay and magnitude change of low coherence light as it is backscattered by ocular tissues. An infrared scanning beam is split into a sample arm and a reference arm. As the sample beam returns to the instrument it is correlated with the reference arm in order to determine distance and signal change via photodetector measurement. The resulting change in signal amplitude allows tissue differentiation by analysis of the reflective properties, which are matched to a false color scale. As the scanning beam moves across tissue, the sequential longitudinal signals, or A-scans, can be reassembled into a transverse scan yielding cross-sectional images, or B-scans, of the subject. The scans can then be analyzed in a variety of ways providing both empirical measurements (e.g. RNFL or retinal thickness/volume) and qualitative morphological information.

Intervention type: DEVICE
Intervention: optical coherence tomography
Description: It generates cross sectional images by analyzing the time delay and magnitude change of low coherence light as it is backscattered by ocular tissues. An infrared scanning beam is split into a sample arm and a reference arm. As the sample beam returns to the instrument it is correlated with the reference arm in order to determine distance and signal change via photodetector measurement. The resulting change in signal amplitude allows tissue differentiation by analysis of the reflective properties, which are matched to a false color scale. As the scanning beam moves across tissue, the sequential longitudinal signals, or A-scans, can be reassembled into a transverse scan yielding cross-sectional images, or B-scans, of the subject. The scans can then be analyzed in a variety of ways providing both empirical measurements (e.g. RNFL or retinal thickness/volume) and qualitative morphological information.
Study: NCT06027593

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Mixed methods intervention
Description: Investigators will implement the intervention at the completion of the rapid user-centered design process and consultation with CDC collaborators.~During the rapid user-centered design process, the team will engage key stakeholders to create and optimize feedback reports that will fit the prescribing context, and determine appropriate implementation supports that will be needed to accompany the introduction of the feedback reports to each setting.~Following the initial awareness-building activities, investigators will circulate the antibiotic prescribing feedback reports. After the first 3 months (approximately) of report dissemination, the team will assess the feasibility and acceptability of the reports and implementation activities by administering a brief survey to prescribers and also conducting interviews with them. No direct identifiers will be collected.
Study: NCT06606483

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MDR-001
Description: Oral administration of small molecule MDR-001 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MDR-001
Description: Oral administration of small molecule MDR-001 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MDR-001
Description: Oral administration of small molecule MDR-001 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MDR-001
Description: Oral administration of small molecule MDR-001 tablets

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered orally placebo
Study: NCT06589960

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Health education and physical exercise
Description: Nine face to face sessions and group discussion health education sessions. An Educational booklet was prepared and distributed to all attendants.~Lab results were discussed individually with each participant.~Rheumatologist and physiotherapist also provided messages.~The exercise program targeted and strengthened the muscles around the knee especially quadriceps muscle, stretching the muscles of lower limbs, and stretching and increasing the range of motion of front and back lower limb muscles (quadriceps muscle, hamstring muscle, gluteus muscle and calf muscles).~Phone calls to follow up the participants and maximize their adherence to the health education program. WhatsApp groups was created, and messages were distributed to summarize the content of the booklet and the exercises videos.~Final reassessment to assess the effect of health education and lifestyle modification was carried out with participants who continued till the end of the study.
Study: NCT06611124

Intervention type: PROCEDURE
Group type: OTHER
Intervention: k -wires fixation for metacarpals fractures
Description: reduction and fixation of metacarpal fracture with k-wire

Intervention type: PROCEDURE
Group type: OTHER
Intervention: k -wires fixation for metacarpals fractures
Description: reduction and fixation of metacarpal fracture with k-wire
Study: NCT06610253

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Protein
Description: Controlled, randomized, single-blind, parallel-group, prospective. Planned, parallel, randomized, single-blind, controlled clinical trial (RCT). Participants will be randomly assigned to one of four interventions: Whey Protein Concentrate - WPC, Pea Protein Isolate - PPI, Rice Protein ISOLATE - RPI, a combination of PPI and RPI to see if the intervention works together in synergy.~The experiment was scheduled for week 8. Each participant will consume 30g of a dedicated preparation every day for 8 weeks. The planned measurements will be performed three times - before the experiment begins, after 4 and 8 weeks.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Protein
Description: Controlled, randomized, single-blind, parallel-group, prospective. Planned, parallel, randomized, single-blind, controlled clinical trial (RCT). Participants will be randomly assigned to one of four interventions: Whey Protein Concentrate - WPC, Pea Protein Isolate - PPI, Rice Protein ISOLATE - RPI, a combination of PPI and RPI to see if the intervention works together in synergy.~The experiment was scheduled for week 8. Each participant will consume 30g of a dedicated preparation every day for 8 weeks. The planned measurements will be performed three times - before the experiment begins, after 4 and 8 weeks.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Protein
Description: Controlled, randomized, single-blind, parallel-group, prospective. Planned, parallel, randomized, single-blind, controlled clinical trial (RCT). Participants will be randomly assigned to one of four interventions: Whey Protein Concentrate - WPC, Pea Protein Isolate - PPI, Rice Protein ISOLATE - RPI, a combination of PPI and RPI to see if the intervention works together in synergy.~The experiment was scheduled for week 8. Each participant will consume 30g of a dedicated preparation every day for 8 weeks. The planned measurements will be performed three times - before the experiment begins, after 4 and 8 weeks.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Protein
Description: Controlled, randomized, single-blind, parallel-group, prospective. Planned, parallel, randomized, single-blind, controlled clinical trial (RCT). Participants will be randomly assigned to one of four interventions: Whey Protein Concentrate - WPC, Pea Protein Isolate - PPI, Rice Protein ISOLATE - RPI, a combination of PPI and RPI to see if the intervention works together in synergy.~The experiment was scheduled for week 8. Each participant will consume 30g of a dedicated preparation every day for 8 weeks. The planned measurements will be performed three times - before the experiment begins, after 4 and 8 weeks.
Study: NCT06610812

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: KETOGENIC MEDITERRANEAN diet
Description: each patient in group A was instructed briefly about the nature of the treatment regimen to gain the patient's confidence and cooperation. the patient will receive ketogenic Mediterranean diet with aerobic training program. The diet will contain approximately 9300 kJ accordingly, 37% as total fat, 18% as monounsaturated and 9% as saturated, and 33 g of fiber per day for 3 months with moderate aerobic exercises in the form of walking from 30 to 45 minutes a day, 3 times per week for 3 months.~This procedure performed by using the components of ketogenic Mediterranean diet:~* Protein source: fatty fish, seafood, poultry, and eggs.~* Fats and oils: olive oil, avocado oil, and MCT oil (medium-chain triglycerides oil).~* Low carb vegetables: leafy greens, cruciferous vegetables, and other low carb veggies.~* Low carb fruits: avocados, olives, and tomato.~* Flavourings: paprika, cumin, cinnamon, coriander, anise, lemon or lime juice , mint , parsley and garlic .

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: hypo-caloric diet:
Description: Group (b) received low caloric balanced diet regimen with aerobic exercise for 3 months in the form of moderate aerobic exercises in the form of walking for 30 to 45 minutes a day, 3 times per week for 3 months. This group received a diet of 1800 calories or lower accordingly including a combination of two or more of the following in each meal: Non starchy vegetable: spinach, broccoli, cauliflower, peppers, mushrooms, tomatoes, etc.~Fruits: berries, apples bears, citrus fruits, melon, grapes bananas, etc. Starchy vegetables: potatoes peas, sweet potatoes etc. Fish and shellfish: salmon, clams, Trouts, oysters, etc. Eggs: whole eggs are more nutrient dense than white eggs. Poultry and meat: chicken turkey, beef, lamb, etc. Whole grains: oats, brown rice, farro etc. Legumes: chickpeas, kidney beans, lentils etc. Healthy fats: avocados, olive oil, unsweetened coconut, avocado oil. Dairy products: full-fat or reduced fat plain yogurt kefir and full-fat cheese.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: moderate aerobic exercises
Description: moderate aerobic exercises in the form of walking from 30 to 45 minutes a day, 3 times per week for 3 months.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: moderate aerobic exercises
Description: moderate aerobic exercises in the form of walking from 30 to 45 minutes a day, 3 times per week for 3 months.
Study: NCT06610825

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Enhertu
Description: This is an open label, multi-center, single arm, phase II study designed to investigate the anti-tumor activity, efficacy and safety of Enhertu in HER2-positive metastatic castrate-resistant prostate cancer patients who progressed on androgen deprivation therapy and novel hormonal agents (such as Abiraterone and Enzalutamide), who also progressed, refused, or were not candidates to receive taxane-based chemotherapy.
Study: NCT06610435

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Manual Therapy
Description: Various soft tissue and joint mobilizations, intramuscular stretches, trigger point treatments, and intraoral applications for the temporomandibular joint were performed in 15 randomly selected bruxism patients. Soft tissue mobilization techniques were applied bilaterally on the trigger points in the masseter, temporal, lateral and medial pterygoid muscles of the masticatory muscles in the transverse direction from inside and outside the mouth. In addition, deep friction massage and myofascial relaxation techniques were applied to suprahyoid and infrahyoid muscles, sternocleidomastoid, scalene, upper trapezius, levator scapula and suboccipital muscles until relaxation was felt. In addition, distraction and bridging techniques were applied in the suboccipital region to release the tissue and fascia techniques were applied in the cervical region to loosen the fascia. The manual therapy procedure, which was applied in the supine position and lasted approximately 40 minutes for 8 weeks

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Home Exercise
Description: The exercise group consisted of 15 randomly selected bruxist individuals and aimed to reduce pain, decrease involuntary contractions of masticatory muscles, increase their nutrition, flexibility and coordination, and strengthen weak muscles with exercise therapy. These exercises consist of resistant isometric jaw movements to increase coordination and relaxation of the masticatory muscles (post isometric relaxation technique), Rocabado exercises, stretching and posture exercises for temporal, masseter and suprahyoid muscles as well as neck muscles. All individuals in this group were taught the programmed exercises practically and were asked to repeat the home exercises (lasting approximately 25 minutes) three times a week for 8 weeks. In addition, a video explaining the exercises in detail was shared with all participants in the group in order to ensure that the exercises were not forgotten and to achieve accuracy and standardization among the participants.
Study: NCT06610500

Intervention type: OTHER
Intervention: Questionnaires
Description: Questionnaires investigating the prescription and dispensing of clozapine.

Intervention type: OTHER
Intervention: Questionnaires
Description: Questionnaires investigating the prescription and dispensing of clozapine.

Intervention type: OTHER
Intervention: Questionnaires
Description: Questionnaires investigating the prescription and dispensing of clozapine.
Study: NCT06610149

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic mixture
Description: 8 weeks treatment with Probiotic mixture
Study: NCT06609811

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Intranasal Influenza Live Attenuated Vaccine
Description: This vaccine is produced by Changchun BCHT Biotechnology Co.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Intranasal Influenza Live Attenuated Vaccine
Description: This vaccine is produced by Changchun BCHT Biotechnology Co.
Study: NCT06610383

Intervention type: PROCEDURE
Intervention: Surgical extraction of wisdom teeth in the morning
Description: The patients in this group underwent impacted tooth surgery at 08:30 in the morning.

Intervention type: PROCEDURE
Intervention: Surgical extraction of wisdom teeth in the afternoon
Description: Impacted tooth surgery was performed on the patients in this group at 15:30.
Study: NCT06440135

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ziftomenib
Description: Taken orally once per day