TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06005545

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Passive Ultrasonic Irrigation (PUI) group
Description: Passive ultrasonic irrigation is the current golden standard in root canal cleaning and irrigation devices. It is used after root canal shaping using manual or rotary instruments. It uses sodium hypochlorite which is mobilized in the canal using ultrasonic non-cutting tips to clean, debride, disinfect, and prepare the root canal for obturation.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Endoclean (EC) group
Description: Endoclean is a novel device that uses hydraulic inertial cavitation with the help of pressure and saline solution to debride the root canal after minimal shaping using manual or rotary shaping instruments. It is used to effectively clean, debride and prepare the root canal before obturation in the root canal treatment procedure.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional group
Description: Conventional root canal preparation uses manual or rotary files along with manual irrigation using syringes and irrigant solutions like sodium hypochlorite or EDTA to clean, debride and prepare the root canal for obturation.
Study: NCT05441228

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Oculus Quest 2
Description: Oculus Quest 2 is virtual reality headset with 2 hand control remotes. Beat Saber application will be used on Oculus Quest 2.

Intervention type: DEVICE
Group type: OTHER
Intervention: Mirror therapy box
Description: Mirror therapy is provided by mirror therapy box by placing it in sagittal plane of patient.
Study: NCT06479382

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: ETX-4143 2.0
Description: Treatment of the eye with the ETX-4143 2.0 device

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ETX-4143 2.0
Description: Treatment of the eye with the ETX-4143 2.0 device
Study: NCT04642248

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Personalized Run Practice
Description: A combination of drills, flexibility, and strength activities combined with a gait retraining program

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Personalized Run Practice
Description: A combination of drills, flexibility, and strength activities combined with a gait retraining program
Study: NCT04824495

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sample
Description: Blood samples at different timepoints during SARS-CoV2 infection
Study: NCT05179213

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azacitidine
Description: 75 mg/m2 subcutaneously on days 1-7

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide
Description: 20mg orally per week continuously
Study: NCT06486792

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban
Description: Patients who have had an ischemic stroke will receive either an anticoagulant or aspirin according to their randomization arm.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aspirin
Description: Aspirin is used as the standard of care
Study: NCT03457051

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Total Knee Arthroplasty (TKA)
Description: In total (complete) knee arthroplasty (TKA), the orthopaedic surgeon removes the damaged areas of the knee and replaces the components with an artificial joint. The device that will be used is: Stryker TKA Triathlon system implant Cruciate retaining radius femur design. This device has been approved for use by Health Canada.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Unicompartmental Knee Arthroplasty (UKA)
Description: Unicompartment (partial) knee arthroplasty (UKA) has been available for over 40 years and differs from TKA in that only the most affected and symptomatic compartment (most commonly medial, but occasionally lateral and patella femoral) are replaced. The device that will be used is: Stryker PKR implant cemented and fixed bearing design. This device has been approved for use by Health Canada.
Study: NCT05298059

Intervention type: RADIATION
Group type: PLACEBO_COMPARATOR
Intervention: Laser of low frequncy
Description: Apply the laser at three points on each tooth.

Intervention type: RADIATION
Group type: PLACEBO_COMPARATOR
Intervention: Laser of low frequncy
Description: Apply the laser at three points on each tooth.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: CPP-ACPF
Description: Apply MI paste plus for five minutes, in the vestibular surface os teeth. During this time patientes should be with closed mounth ad should not talk or to split.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: CPP-ACPF
Description: Apply MI paste plus for five minutes, in the vestibular surface os teeth. During this time patientes should be with closed mounth ad should not talk or to split.
Study: NCT04636736

Intervention type: DIAGNOSTIC_TEST
Intervention: HIV drug resistance testing
Description: HIV drug resistance testing in people newly diagnosed in HIV in Poland

Intervention type: DIAGNOSTIC_TEST
Intervention: HIV drug resistance testing
Description: HIV drug resistance testing in people newly diagnosed in HIV in Poland
Study: NCT05534139

Intervention type: DIAGNOSTIC_TEST
Intervention: 7T MRI-scan
Description: MRI-scanning of the brain using a 7T-MRI scanner

Intervention type: DIAGNOSTIC_TEST
Intervention: 7T MRI-scan
Description: MRI-scanning of the brain using a 7T-MRI scanner

Intervention type: DIAGNOSTIC_TEST
Intervention: 7T MRI-scan
Description: MRI-scanning of the brain using a 7T-MRI scanner

Intervention type: DIAGNOSTIC_TEST
Intervention: 7T MRI-scan
Description: MRI-scanning of the brain using a 7T-MRI scanner

Intervention type: DIAGNOSTIC_TEST
Intervention: CSF collection via lumbar puncture
Description: CSF is collected by doing a lumbar puncture

Intervention type: DIAGNOSTIC_TEST
Intervention: CSF collection via lumbar puncture
Description: CSF is collected by doing a lumbar puncture

Intervention type: DIAGNOSTIC_TEST
Intervention: CSF collection via lumbar puncture
Description: CSF is collected by doing a lumbar puncture

Intervention type: DIAGNOSTIC_TEST
Intervention: CSF collection via lumbar puncture
Description: CSF is collected by doing a lumbar puncture

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood withdrawal
Description: Blood is collected by doing a blood withdrawal

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood withdrawal
Description: Blood is collected by doing a blood withdrawal

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood withdrawal
Description: Blood is collected by doing a blood withdrawal

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood withdrawal
Description: Blood is collected by doing a blood withdrawal

Intervention type: DIAGNOSTIC_TEST
Intervention: Clinical measures
Description: UHDRS-Total motor score, UHDRS-short problem behaviour assessment, UHDRS-Cognitive assessments

Intervention type: DIAGNOSTIC_TEST
Intervention: Clinical measures
Description: UHDRS-Total motor score, UHDRS-short problem behaviour assessment, UHDRS-Cognitive assessments

Intervention type: DIAGNOSTIC_TEST
Intervention: Clinical measures
Description: UHDRS-Total motor score, UHDRS-short problem behaviour assessment, UHDRS-Cognitive assessments

Intervention type: DIAGNOSTIC_TEST
Intervention: Clinical measures
Description: UHDRS-Total motor score, UHDRS-short problem behaviour assessment, UHDRS-Cognitive assessments
Study: NCT06086990

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Contigo Application
Description: Contigo, a smartphone app, focuses on two main goals: monitoring cancer patients for early signs of drug toxicity and offering educational content to empower them in managing clinical challenges linked to their diagnosis and treatment. Monitoring involves patients inputting experiences via oncology-related questionnaires, with weekly checks for chemotherapy toxicity using a validated questionnaire (PRO-CTCAE). Severe cases trigger alerts, while milder ones receive educational guidance. Data collected is shared with healthcare providers. Educational content, backed by scientific evidence and expert collaboration, covers cancer-specific topics and healthcare processes to enhance patients' self-awareness and self-care practices.
Study: NCT04795063

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Total Robotic Distal Gastrectomy
Description: All the surgical procedures are performed using the robot system.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Robotic-Assisted Distal Gastrectomy
Description: After finishing the lymphadenectomy, the digestive tract reconstruction is performed extracorporal.
Study: NCT03523156

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Azithromycin mass treatment
Description: Standard of care annual community-wide mass drug administration (MDA) will be provided at the normally scheduled time.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin mass treatment
Description: Standard of care annual community-wide mass drug administration (MDA) will be provided at the normally scheduled time.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin targeted treatment
Description: Two rounds of treatment targeted to all children aged 2 to 9 years old. The first targeted round will be 1-2 weeks after the community-wide MDA and the second round will occur another 1-2 weeks later.
Study: NCT04553666

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Epigallocatechin-3-Gallate (EGCG) plus Ascorbic Acid (Vitamin C)
Description: 800mg Epigallocatechin-3-Gallate (EGCG) plus 250mg Ascorbic Acid (Vitamin C) taken one time a day for twelve weeks
Study: NCT06235112

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Electronic health record-based notification of Nanox.AI Coronary Artery Calcification Assessment
Description: The intervention involves electronic health record, email, or letter notification about the presence of coronary artery calcification on chest CT and recommendation of preventive therapy. This is based on results of the automatic detection of coronary artery calcification from AI device (software).
Study: NCT06165432

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Topical Benzocaine
Description: Benzocaine topical anesthetic gel will be used a pre-injection anesthetic on one half of the palate before giving greater palatine nerve block

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Topical ice
Description: For the other half of the palate topical ice would be used before greater palatine nerve block
Study: NCT05793749

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Prophylactic lymphedema treatment
Description: 1. perform manual lymphatic drainage twice a week after the start of radiotherapy for a total of 10 times, and wear lymphedema compression stockings after each manual lymphatic drainage, 2. teach patients how to care for their skin. 3. perform functional exercises for lymphedema of the lower extremities twice a day for 15 \~ 20 minutes each time. 4. follow up observation: before the start of radiotherapy, every Friday during radiotherapy, and every 3 months after the end of radiotherapy, the occurrence of lymphedema and related symptoms and quality of life were evaluated.
Study: NCT05673447

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: anti-CD19 CAR NK cells
Description: Patients will receive Fludarabine (30 mg/m2 per day) and Cyclophosphamide (300mg/m2 per day) on day -5, -4, and -3. Doses of 6×10\^8, 1×10\^9, 1.5×10\^9 Anti-CD19 CAR NK cells will infused in each group using the 3 + 3 dose-escalation strategy.
Study: NCT04140773

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: D-serine
Description: Capsule D-serine

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Capsule D-serine
Study: NCT06077344

Intervention type: PROCEDURE
Intervention: WALANT in Ankle Fractures (Wide-Awake Local) Anesthesia No Tourniquet) and Applied Under Spinal Anesthesia Comparison of Clinical Results of Surgical Treatment;ANT Procedure comparation
Description: WALANT in Ankle Fractures (Wide-Awake Local) Anesthesia No Tourniquet) and Applied Under Spinal Anesthesia Comparison of Clinical Results of Surgical Treatment;ANT Procedure comparation

Intervention type: PROCEDURE
Intervention: Applied Under Spinal Anesthesia of Clinical Results of Surgical Treatment
Description: Applied Under Spinal Anesthesia of Clinical Results of Surgical Treatment
Study: NCT05654571

Intervention type: DIAGNOSTIC_TEST
Intervention: mammography
Description: All patients are checked for mammography every year after surgery.

Intervention type: DIAGNOSTIC_TEST
Intervention: mammography
Description: All patients are checked for mammography every year after surgery.
Study: NCT05861830

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: The combination of Dalpiciclib with physician-selected endocrine therapy
Description: * Dalpiciclib: 150 mg, orally, once daily, on days 1-21, every 28 days (3 weeks on, 1 week off)~* Letrozole: 2.5 mg, orally, once daily (continuous), every 28 days OR Anastrozole: 1.0 mg, orally, once daily (continuous), every 28 days OR Exemestane: 25 mg, orally, once daily (continuous), every 28 days OR Fulvestrant: 500 mg, intramuscular injection on day 1/15 of the first cycle, then on day 1 of each subsequent cycle, every 28 days OR Tamoxifen: 10-20 mg, orally, twice daily (continuous), every 28 days~* Pre/perimenopausal women also require ovarian function suppression (OFS), which can be achieved through bilateral oophorectomy or the use of gonadotropin-releasing hormone (GnRH) analog drugs

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Chemotherapy selected by the physician
Description: The chemotherapy regimen is chosen by the clinical physician and may include, but is not limited to, the following options: the combination of paclitaxel and capecitabine, the combination of paclitaxel and carboplatin, single-agent capecitabine, single-agent platinum drugs, and the combination of gemcitabine and platinum-based chemotherapy. Each treatment cycle consists of a 21-day duration.
Study: NCT05323955

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab
Description: Administer per current package insert based on site standard of care guidelines

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab Emtansine (T-DM1)
Description: Administer per current package insert based on site standard of care guidelines

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pertuzumab
Description: Administer per current package insert based on site standard of care guidelines

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tucatinib
Description: 300 mg orally twice daily (21 Day Cycle)
Study: NCT06365788

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Abemaciclib
Description: 150 mg tablet orally twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bicalutamide
Description: 150 mg tablet orally once daily
Study: NCT05877898

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CHW Education
Description: Participants will be invited to meet with the CHW to learn about eating healthier to reduce blood pressure and enhance quantity and quality of life.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CHW Education and Navigation
Description: Participants will be invited to complete all the CHW education arm material and be offered a menu of optional services for personalization including: (1) transportation to the grocery store (weekly for 4 weeks), (2) culturally adapted hypertension-tailored cooking recipes, (3) a virtual cooking class with food delivered to their door led by community partner, (4) access to UF IFAS's online library of healthy food cooking videos, and (5) in-store education on food labels, grocery shopping, and food resource management skills through the Cooking Matters at the Store curricula.
Study: NCT06505590

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Educational content
Description: Patients will have access to educational content on the mobile app Resilience © in the format of articles, videos or podcasts on treatment related symptoms and on validated supportive care interventions. This version is currently public available in France and Belgium at www.resilience.care and is considered the control group (education only).

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Educational material plus self-management program - self-administered version
Description: Patients will have access to the same mobile app (Resilience ©) with its educational content will be powered with a self-guided fatigue self-management program based on a cognitive behavioral therapy approach.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Educational material plus self-management program - guided version with mental health professional
Description: Patients will have access to the same mobile app (Resilience ©) with its educational content and the self-management program of arm 2 and weekly calls with a certified mental health professional certified in cognitive behavioural therapy for guided coaching across the self-management program.
Study: NCT05781867

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Manual therapy and conventional physical therapy treatment
Description: manual therapy (chest mobilization, diaphragmatic myofascial release, myofascial release for pectoralis minor, pectoralis major, scaleni ),pursed lip breathing, diaphragmatic breathing and active range of motion exercises of upper limbs

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Manual therapy and conventional physical therapy treatment
Description: manual therapy (chest mobilization, diaphragmatic myofascial release, myofascial release for pectoralis minor, pectoralis major, scaleni ),pursed lip breathing, diaphragmatic breathing and active range of motion exercises of upper limbs
Study: NCT05945212

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SPM - Statistical Parametric Mapping
Description: Addition of a temporal component to the traditional quantified gait analysis, allowing the focus to be on time series parameters.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: SPM - Statistical Parametric Mapping
Description: Addition of a temporal component to the traditional quantified gait analysis, allowing the focus to be on time series parameters.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: FACIT questionnaire (Functional Assessment of Chronic Illness Therapy)
Description: A short questionnaire consisting of 13 questions to which the patient answers on a scale from 0 to 4. The scores are simply added up, inverting the scale for negative sentences, to give a result out of 52 points. The lower the score, the greater the fatigue.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: FACIT questionnaire (Functional Assessment of Chronic Illness Therapy)
Description: A short questionnaire consisting of 13 questions to which the patient answers on a scale from 0 to 4. The scores are simply added up, inverting the scale for negative sentences, to give a result out of 52 points. The lower the score, the greater the fatigue.
Study: NCT06333028

Intervention type: DEVICE
Intervention: enVista Aspire EA IOLs
Description: Subjects bilaterally implanted with enVista Aspire EA IOLs
Study: NCT06078215

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Cerebrolysin
Description: Intravenous infusion of 30 ml Cerebrolysine in 500 ml of buffered crystalloid solution intravenously initiated within 12 hours from symptoms onset
Study: NCT05353088

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: scapular stabilization
Description: Scapular stabilization exercise aims to restore scapular position, orientations, motor control of muscles, and movement pattern, thereby attaining stability of scapula for better kinematics of shoulder.scapular stabilization exercises for 4 weeks with 2 sets of 10 repetitions. These exercises comprised of four exercise programs (Scapular retraction; Scapular mobilization, Scapular dynamic stabilization I and Scapular dynamic stabilization II)

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Thoracic extension exercises
Description: Thoracic extension involves concurrent posterior rotation (external torsion) and depression of the posterior ribs with elevation of the anterior ribs. Bending to the side is a combination of spinal segments side bending, ribs on the same come together while ribs on the opposite side separate.Group B performed thoracic extension exercises for 4 weeks with 2 sets of 10 repetitions. These exercises comprised of three exercise programs.
Study: NCT04835545

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: extreme hypercapnia induced by ventilation insufficiency
Description: extreme hypercapnia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: extreme hypercapnia induced by ventilation insufficiency
Description: extreme hypercapnia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: extreme hypercapnia induced by ventilation insufficiency
Description: extreme hypercapnia
Study: NCT06147934

Intervention type: DIAGNOSTIC_TEST
Intervention: Diagnostic Test: Transient elastography (TE) and 2D-shear wave elastography (2D-SWE)
Description: Index test: TE examination will be completed by experienced nurses, requiring fasting for more than 4 hours before the examination and an interval of no more than 1 week from the abdominal ultrasound and 2D-SWE examination. The report will be considered highly reliable only if IQR/med is ≤ 30%, at least 10 successful acquisitions are obtained, and the success rate is at least 60%. Abdominal ultrasound and 2D-shear wave elastography (2D-SWE) will be completed by a sonographer, the interval between ultrasonic examination and laboratory tests should be less than a week, and the patients should fast for at least 4 hours before the examination.~Reference standard: Liver biopsy will be conducted by experienced interventionists and reported by pathologists. There should be a maximum interval of no more than 1 month between the liver biopsy and ultrasound examination, and the length of specimen should be more than 1.0cm.
Study: NCT05514730

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Phase-based Treatment (PBT) for Problematic Sexual Behavior of Preteen Children
Description: PBT is a skills-based protocol that primarily works with caregivers to manage problematic behavior and to teach children healthy information about sex and sexuality. It was designed based on the current empirical knowledge regarding the etiology and treatment of childhood problematic sexual behavior. It is delivered in 12 weekly sessions, with each session lasting approximately 50 minutes.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment-as-Usual (TAU)
Description: The TAU intervention designed for this trial relies largely on the delivery of child-focused treatment techniques, particularly on the development of therapeutic rapport through the utilization of non-directive techniques. These sessions are supplemented with educational materials for the caregiver on child behavior and parenting recommendations. This treatment is designed to be administered over 12 weekly sessions, with each session lasting approximately 50 minutes.