Study: NCT06299098

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part A
Description: Administered IV or SC in Part A

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trevogrumab-Part B and Part C
Description: Administered SC in Part B, Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Garetosmab
Description: Administered IV in Part B

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Garetosmab
Description: Administered IV in Part B

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Semaglutide
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Matching Placebo-Part A
Description: Administered IV or SC in Part A

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Trevogrumab
Description: Administered SC in Part B and Part C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Garetosmab
Description: Administered IV in Part B

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Garetosmab
Description: Administered IV in Part B

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Garetosmab
Description: Administered IV in Part B

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Garetosmab
Description: Administered IV in Part B

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Garetosmab
Description: Administered IV in Part B

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching Placebo-Garetosmab
Description: Administered IV in Part B