TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05560607

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD7503 Intervention
Description: Part A: Participants will be screened for histologic evidence of NAFLD or NASH and all eligibility criteria in part A prior to enrollment in part B.~Part B: Participants consented to part B will be administered the study drug over the course of 31 days. At the end of the study a liver biopsy will be collected to measure for endpoints.
Study: NCT05554601

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: gamification with collaboration
Description: participants receive a FitBit and set goals, then are assigned to a group of other participants who will play a game to gain points based on collaboration

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: gamification with competition
Description: participants receive a FitBit and set goals, then are assigned to a group of other participants who will play a game to gain points based on competition with each other
Study: NCT06551285

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Ovapro (Lifepro)
Description: Dietary supplement that contains inositol, vitamin D, zinc, and curcumin.
Study: NCT06023472

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: density gradient centrifugation
Description: Density-gradient centrifugation is a commonly used method for sperm separation and purification. It is a technique that involves layering a semen sample on top of a gradient of different densities of a solution, typically a mixture of colloidal silica and sucrose, and then centrifuging the sample. The centrifugal force causes the sperm to migrate through the gradient, where they become separated based on their density.
Study: NCT05670158

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood sampling
Description: Blood will be collected into 2 EDTA and 1 heparin tube. The 2 EDTA tubes (4ml of blood in each) will be transported on ice to the proteomics platform in the next three hours, centrifuged and stored on -80 degrees Celcius in low-binding tubes for further molecular analysis. 1 heparin tube (5mL) will be sent to the Bacteriology-Virology Department for the active PBMC counting.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: Blood sampling
Description: Blood will be collected into 2 EDTA and 1 heparin tube. The 2 EDTA tubes (4ml of blood in each) will be transported on ice to the proteomics platform in the next three hours, centrifuged and stored on -80 degrees Celcius in low-binding tubes for further molecular analysis. 1 heparin tube (5mL) will be sent to the Bacteriology-Virology Department for the active PBMC counting.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Perilymph sampling
Description: The perilymph collection will be performed during the cochlear implantation surgery at the same time as the round window opening. 5 to 15 microliters will be aspirated using an atraumatic spinal needle mounted onto 1 ml insulin syringe.
Study: NCT05433025

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cervigard Neck Collar
Description: A device used to treat neck pain caused by forward head posture
Study: NCT05253885

Intervention type: DEVICE
Intervention: Smartphone use
Description: * Smartphone addiction scale (short version) higher than 33~* Smartphone users of 4-5 inches screen size smartphones, weighing 140-160 grams and dimensions less than 159\*79\*9 mm.
Study: NCT06309589

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vitamin D
Description: experimental group received UDCA combined with vitamin D3 (1200 IU per day) treatment
Study: NCT04909203

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: iKinnect2.0
Description: iKinnect2.0 is a paired mobile phone app for use on both Android and iOS operating systems by youth with conduct disorders and their parents.
Study: NCT06369402

Intervention type: DIAGNOSTIC_TEST
Intervention: Cerebral haemodynamic testing using transcranial Doppler
Description: Measurement of cerebral haemodynamics using transcranial Doppler to insonate the middle cerebral arteries bilaterally testing neurovascular coupling with selected domains from the Addenbrooks cognitive examination III and the digit span forward and backwards.

Intervention type: DIAGNOSTIC_TEST
Intervention: Cerebral haemodynamic testing using transcranial Doppler
Description: Measurement of cerebral haemodynamics using transcranial Doppler to insonate the middle cerebral arteries bilaterally testing neurovascular coupling with selected domains from the Addenbrooks cognitive examination III and the digit span forward and backwards.

Intervention type: DIAGNOSTIC_TEST
Intervention: Ankle-brachial pressure index
Description: Ratio of ankle to brachial blood pressure measured using handheld Doppler at rest and after exercise (six-minute walk test).

Intervention type: DIAGNOSTIC_TEST
Intervention: Ankle-brachial pressure index
Description: Ratio of ankle to brachial blood pressure measured using handheld Doppler at rest and after exercise (six-minute walk test).

Intervention type: DIAGNOSTIC_TEST
Intervention: Six-minute walk test
Description: Supervised brisk walk for six minutes. Time and distance to onset of claudication pain and total distance walked (and total time walked if did not complete the full six minutes).

Intervention type: DIAGNOSTIC_TEST
Intervention: Six-minute walk test
Description: Supervised brisk walk for six minutes. Time and distance to onset of claudication pain and total distance walked (and total time walked if did not complete the full six minutes).
Study: NCT05338905

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Palliative Therapy
Description: Receive standard symptom management

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Quality-of-Life Assessment
Description: Complete quality of life questionnaire

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaire Administration
Description: Complete quality of life questionnaire
Study: NCT05423275

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Negative ion therapy
Description: Negative ion generator

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Light therapy
Description: Fluorescent light box
Study: NCT06380374

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gamification in Disaster Nursing Education
Description: The contact information of the students who meet the inclusion criteria will be collected by the researchers. The topic of disaster nursing will be explained to all students enrolled in the course by the researcher in the classroom environment. Pre-tests will be taken from students attending the course on disaster nursing. Randomization will be carried out by the researcher, who does not have an active role in the research process. Students in the experimental and control groups will be hidden from the researchers, who will conduct the application until it begins. The Program will be carried out face-to-face. Students in the experimental group will be on the playground. Students will attend the sessions in groups of 6. Each student will compete independently within the group, and each group will have a winner. Students will encounter a total of 30 questions in each game round. The entire game process consists of 7 sessions. After the game process is completed, post-tests will be taken.
Study: NCT05854719

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Speechreading training with an application
Description: The Optic Track application developed for this intervention will be used in speechreading training. The target is that, during the eight intervention weeks, it would be used for 15 minutes at least three times a week.
Study: NCT05934422

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention (Study Nutritional Drink)
Description: Study nutritional drink containing a mix of enriched micronutrients, probiotics and myo-inositol.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control (Standard Nutritional Drink)
Description: Control nutritional drink containing a standard mix of micronutrients
Study: NCT06260995

Intervention type: OTHER
Intervention: Social Prescribing Link Worker Intermediary Intervention
Description: Social prescribing link workers \[SPLW\] receive referrals from healthcare professionals, community services, or through self-referral. Individuals are referred for social isolation or social needs, frequent healthcare attendance, or to address a pre-existing health issue. SPLW carry out an in-depth assessment of the individual's needs, and then work with the individual over weeks and months to connect them to community services and supports, which can include local physical activities. They use several strategies during this follow-up period, such as instrumental support (doing things for the individual), empowerment and motivation techniques and/or attending activities with the individual. After the SPLW establishes a connection to a local physical activity, the individual enrols and participates in the chosen activity. Local physical activities can include walking groups, local gyms and leisure centres, chair-based exercise, outdoor activities, yoga and tai chi.

Intervention type: OTHER
Intervention: Local Sports Partnership Community Development Officer Intervention
Description: Local sports partnership community development officers \[LSPO\] mainly receive self-referrals, or can receive referrals, to improve physical activity levels of individuals through participation in physical activity groups delivered by the partnership. LSPO do not carry out an in-depth assessment but may carry out screening before explaining/signposting to local physical activities. They use several strategies to connect the individual to local physical activities, such as attending the first session of the group, providing reassurance and practical support, and keeping the person updated and informed as to upcoming groups. After the LSPO establishes a connection to a local physical activity, the individual enrols and participated in the chosen activity. The LSPO continues to support this engagement during the follow-up period. Local physical activities can include walking groups, local gyms and leisure centres, chair-based exercise, outdoor activities, yoga and tai chi amongst others.
Study: NCT05679401

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Imlifidase
Description: Imlifidase is an immunoglobulin G (IgG)-degrading enzyme of Streptococcus pyogenes that is highly selective towards IgG. The cleavage of IgG generates one F(ab')2- and one homodimeric Fc-fragment and efficiently neutralizes Fc-mediated activities of IgG.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Plasma exchange (PLEX)
Description: PLEX removes the patient's pathogenic anti-GBM antibodies, by replacement of deficient plasma with a replacement fluid.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Plasma exchange (PLEX)
Description: PLEX removes the patient's pathogenic anti-GBM antibodies, by replacement of deficient plasma with a replacement fluid.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide (CYC)
Description: Cyclophosphamide's main mechanism of action (i.e. crosslinking of strands of DNA and RNA) results in inhibition of protein synthesis. Hence treatment prevents formation of new anti-GBM antibodies.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclophosphamide (CYC)
Description: Cyclophosphamide's main mechanism of action (i.e. crosslinking of strands of DNA and RNA) results in inhibition of protein synthesis. Hence treatment prevents formation of new anti-GBM antibodies.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Glucocorticoids
Description: Glucocorticoids inhibit the inflammation process.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Glucocorticoids
Description: Glucocorticoids inhibit the inflammation process.
Study: NCT06018389

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Structural only
Description: A shared list of school policies for or related to, school-based social events at school premises. The policy initiatives include (but are not limited to): increasing the number of social events without alcohol; promoting non-alcoholic beverages at parties; working with student associations regarding their roles and responsibilities; encouraging parental involvement at school events and disseminating the schools' alcohol policy among students and parents. The school principal and management will be responsible for the implementation and enforcement of the policies.~The Information-based interactive parent meetings will be 45 minutes and will take place at the schools. Parents will be offered concrete, research-informed advice about how they can reduce risk of hazardous substance use and promote well-being among their adolescents. Following a 15-minute presentation, the group leader facilitates a discussion and exchange of experience between parents.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Structural only
Description: A shared list of school policies for or related to, school-based social events at school premises. The policy initiatives include (but are not limited to): increasing the number of social events without alcohol; promoting non-alcoholic beverages at parties; working with student associations regarding their roles and responsibilities; encouraging parental involvement at school events and disseminating the schools' alcohol policy among students and parents. The school principal and management will be responsible for the implementation and enforcement of the policies.~The Information-based interactive parent meetings will be 45 minutes and will take place at the schools. Parents will be offered concrete, research-informed advice about how they can reduce risk of hazardous substance use and promote well-being among their adolescents. Following a 15-minute presentation, the group leader facilitates a discussion and exchange of experience between parents.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Structural+Group MI
Description: Within school classes, students are divided into groups of 5-8 students and each group will be assigned a group leader from the research team. The group-based Motivational Interviewing (group MI) is manualized and consists of two one-hour group sessions administered over two consecutive weeks. The first session is focused on Tell your story, Gains from not drinking, and Social norms. In the second session, the focus is on Personal values, Linking values with behavior and Planning/choices regarding alcohol. Both group MI sessions will take place at the schools during the school day.
Study: NCT04909203

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Active Control App
Description: Mobile phone app for use on both Android and iOS operating systems for GPS tracking of other persons.
Study: NCT05802862

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Insulin Degludec and Insulin Aspart
Description: administered subcutaneously, once a day

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Insulin Degludec and Insulin Aspart
Description: administered subcutaneously, once a day
Study: NCT05516719

Intervention type: OTHER
Intervention: Positron Emission Tomography (PET) scan using BU99008 tracer
Description: A positron emission tomography (PET) scan produce detailed 3-dimensional images of the inside of the body by showing radiation from tracers used to highlight specific areas of the brain.

Intervention type: OTHER
Intervention: Positron Emission Tomography (PET) scan using BU99008 tracer
Description: A positron emission tomography (PET) scan produce detailed 3-dimensional images of the inside of the body by showing radiation from tracers used to highlight specific areas of the brain.

Intervention type: OTHER
Intervention: Positron Emission Tomography (PET) scan using BU99008 tracer
Description: A positron emission tomography (PET) scan produce detailed 3-dimensional images of the inside of the body by showing radiation from tracers used to highlight specific areas of the brain.

Intervention type: OTHER
Intervention: FP-CIT Single-photon Emission Computed Tomography (SPECT) scan
Description: A single-photon emission computerized tomography (SPECT) scan allows analysis of brain function by creating 3D Pictures using compounds called tracers.

Intervention type: OTHER
Intervention: FP-CIT Single-photon Emission Computed Tomography (SPECT) scan
Description: A single-photon emission computerized tomography (SPECT) scan allows analysis of brain function by creating 3D Pictures using compounds called tracers.

Intervention type: OTHER
Intervention: FP-CIT Single-photon Emission Computed Tomography (SPECT) scan
Description: A single-photon emission computerized tomography (SPECT) scan allows analysis of brain function by creating 3D Pictures using compounds called tracers.

Intervention type: OTHER
Intervention: Magnetic Resonance Imaging (MRI) Scan
Description: MRI (magnetic resonance imaging) uses magnets alongside radio waves to create pictures of the brain.

Intervention type: OTHER
Intervention: Magnetic Resonance Imaging (MRI) Scan
Description: MRI (magnetic resonance imaging) uses magnets alongside radio waves to create pictures of the brain.

Intervention type: OTHER
Intervention: Magnetic Resonance Imaging (MRI) Scan
Description: MRI (magnetic resonance imaging) uses magnets alongside radio waves to create pictures of the brain.

Intervention type: OTHER
Intervention: Lumbar puncture
Description: A lumbar puncture is where a thin needle is inserted between the bones in your lower spine using local anaesthetic. This allows the collection of Cerebrospinal fluid ( CSF)

Intervention type: OTHER
Intervention: Lumbar puncture
Description: A lumbar puncture is where a thin needle is inserted between the bones in your lower spine using local anaesthetic. This allows the collection of Cerebrospinal fluid ( CSF)

Intervention type: OTHER
Intervention: Lumbar puncture
Description: A lumbar puncture is where a thin needle is inserted between the bones in your lower spine using local anaesthetic. This allows the collection of Cerebrospinal fluid ( CSF)
Study: NCT05096689

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: MRI
Description: Magnetic Resonance Imaging
Study: NCT05564039

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tirzepatide
Description: Administered SC

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dulaglutide
Description: Administered SC
Study: NCT05822622

Intervention type: OTHER
Intervention: echocardiography
Description: to determine finding of heart failure with preserved ejection fraction and non alcoholic fatty liver disease

Intervention type: OTHER
Intervention: echocardiography
Description: to determine finding of heart failure with preserved ejection fraction and non alcoholic fatty liver disease
Study: NCT04906759

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Meals plus exercise
Description: Participants will receive 12 weeks of a MOW delivery service that will include 2 meals per day during the weekdays with 4 shelf-stable meals at the end of the week. The MOW driver will visit the participants in-person to ask a series of 5 questions about change in health status, joint/muscle injuries, new pain, falls, and poor appetite twice a week. Participants will also will receive an exercise kit from the MOW driver with their first meal delivery which will contain 2 tennis balls, 2 1-pound hand weights, and one towel. Every week, the driver will give the participants a handout containing 3 exercises from the NIA Go4Life Workout-to-Go book that are designed to help with strength/endurance, balance, and flexibility20. The participants will be asked to do the 3 exercises every day, if possible, on their own. Every 4 weeks during the 12-week study period and at 6 months follow up patients will have blood drawn for frailty and inflammatory biomarkers.
Study: NCT06551285

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Ovapro (Lifepro)
Description: Dietary supplement that contains inositol, vitamin D, zinc, and curcumin.
Study: NCT04906759

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Meals only
Description: Participants will receive 12 weeks of a MOW delivery service that will include 2 meals per day during the weekdays with 4 shelf-stable meals at the end of the week. The MOW driver will visit the participants in-person to ask a series of 5 questions about change in health status, joint/muscle injuries, new pain, falls, and poor appetite twice a week. they will be asked to continue their usual level of activity.Every 4 weeks during the 12-week study period and at 6 months follow up patients will have blood drawn for frailty and inflammatory biomarkers.
Study: NCT05714774

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: HIFU treatment of prostate cancer
Description: HIFU treatment using Focal One (EDAP TMS) combined with the acquisition of additional ultrasound images before, between, and after HIFU shots will be performed.
Study: NCT06412289

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: US-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY
Description: The ultrasound investigation will be conducted using the ultrasound machine supplied to the Center involved in the trial and usually used in eTTNA procedures. Before the procedure, the vital signs of the patient will be noted and each operator will choose the most appropriate position for the sampling, based on the location of the lesion. The thoracic area to biopsy will then be defined and then there will be the setting of the sterile field. At this point, local anesthesia with a maximum of 20ml of 2% lidocaine will be administrated, marking down this time as the time of the beginning of the procedure. 18 Gauge needles will be used to collect the sample. For each patient, there will be collected a minimum number of one and a maximum number of three bioptic sampling .

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: CT-GUIDED PERCUTANEOUS LUNG NEEDLE BIOPSY
Description: The CT scan will be performed using the CT machinery equipped by the Center involved in the trial and usually used for the tTTNA procedures. Before the procedure, the vital signs of the patient will be noted and each operator will choose the most appropriate position for the sampling, based on the location of the lesion. The thoracic area to biopsy will then be defined and then there will be the setting of the sterile field. At this point, local anesthesia with a maximum of 20ml of 2% lidocaine will be administrated, marking down this time as the time of the beginning of the procedure. 18 Gauge needles will be used to collect the sample. For each patient, there will be collected a minimum number of one and a maximum number of three bioptic sampling .
Study: NCT06280079

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ultra-high-caloric fatty diet
Description: 100% fat (70g), saturated fatty acids 7,5g, monounsaturated fatty acids 42,6g, polyunsaturated fatty acids 19,9g, long-chain fatty acids 100%, ratio omega-6 to omega-3 fatty acids 5:1, protein 0g, carbohydrates 0g, fiber 0g

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: \<5% fat (\<3,5g), protein 0g, carbohydrates 0g, fiber 0g
Study: NCT05894785

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: External cephalic version
Description: An ECV attempt is made on the study group