TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04931485

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fluid management according to the REDUCE Fluid Protocol
Description: Fluid management according to the protocol will be guided by pre-defined clinical signs for impaired perfusion and fluid overload.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard of care
Description: Fluid resuscitation and de-resuscitation will be managed according to the standard of care
Study: NCT05661981

Intervention type: DEVICE
Intervention: GLYCAR Pericardial Patch
Description: The Glycar patches are intended to be used by surgeons specialized in the field of cardiovascular surgery. The patch is intended to be used for pericardial closure, or repair and/or reconstruction of cardiovascular structures by replacing missing tissue, reinforcing weakened tissue and providing extra strength to repair tissue during healing.
Study: NCT05854771

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Single bout of yoga before eccentric exercise
Description: The participants will perform a single bout of the following 5 yoga poses; Child's pose, Thread the needle pose, Eagle arms, Cow face pose, Hands overhead in wide-legged forward bend before the eccentric exercise designed to induce delayed onset muscle soreness for a total time duration of 20-30 minutes. The participants will be asked to breathe and hold each yoga pose for 6-8 breaths. For induction of delayed onset muscle soreness, one repetition maximum of each participant will be calculated first, and on the basis of one repetition maximum the participants will perform 6 sets of 10 repetitions of the eccentric drills of elbow and knee flexors and extensors with 3 minutes rest period between each set.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Single bout of yoga after eccentric exercise
Description: The participants will perform a single bout of the following 5 yoga poses; Child's pose, Thread the needle pose, Eagle arms, Cow face pose, Hands overhead in wide-legged forward bend after the eccentric exercise designed to induce delayed onset muscle soreness for a total time duration of 20-30 minutes. The participants will be asked to breathe and hold each yoga pose for 6-8 breaths. For induction of delayed onset muscle soreness, one repetition of each participant will be calculated first and on the basis of one repetition maximum the participants will perform 6 sets of 10 repetitions of the eccentric drills of elbow and knee flexors and extensors with 3 minutes rest period between each set.
Study: NCT05212688

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Acupuncture
Description: Weekly treatment of 15 minutes for 6 weeks using Seirin 36 g 30 mm needles applied to two upper midline sternal points, thoracic paravertebral points, 5 pairs, 2 bilateral Trapezius trigger points, LI4, TE5, ST36, GB34, SP6, LR3 bilaterally, GV20 \& GV24 midline.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Active Control
Description: Weekly contact once per week for 6 weeks for a semi-structured telephone consultation.
Study: NCT06272136

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Clinical Demo 2.0
Description: During the different glycaemia states, transcutaneous spectral data are collected continuously with the device and paired with reference measurements (venous blood and interstitial fluid)
Study: NCT06510556

Intervention type: DEVICE
Group type: OTHER
Intervention: Ablation Treatment
Description: Subjects scheduled to undergo endocardial mapping and ablation therapy in the treatment of persistent atrial fibrillation. Ablation of the pulmonary veins and left atrial posterior wall will be performed; ablation of the cavo-tricuspid isthmus (CTI) is at the discretion of the investigator.
Study: NCT06350526

Intervention type: DIAGNOSTIC_TEST
Intervention: Complete Blood Count
Description: blood sample

Intervention type: DIAGNOSTIC_TEST
Intervention: C-reactive protein
Description: serum sample

Intervention type: DIAGNOSTIC_TEST
Intervention: O2 saturation
Description: blood sample

Intervention type: DIAGNOSTIC_TEST
Intervention: Serum ferritin and D-dimer
Description: Blood sample

Intervention type: DIAGNOSTIC_TEST
Intervention: Liver and renal function tests
Description: Blood sample

Intervention type: DIAGNOSTIC_TEST
Intervention: Lactate dehydrogenase
Description: Blood sample

Intervention type: DIAGNOSTIC_TEST
Intervention: coronavirus (SARS-CoV-2) swab
Description: Throat swab

Intervention type: RADIATION
Intervention: CT chest
Description: Radiation
Study: NCT06506019

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: 25 mg psilocybin

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Functional MRI
Description: The fMRI involving resting state measures and a facial affect task will be conducted one-day and one-month after the dosing session.
Study: NCT05981703

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BGB-26808
Description: Planned doses administered orally as a tablet daily.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BGB-26808
Description: Planned doses administered orally as a tablet daily.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tislelizumab
Description: Planned doses administered by intravenous infusion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tislelizumab
Description: Planned doses administered by intravenous infusion.
Study: NCT05933200

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Triheptanoin
Description: Liquid for oral (PO) or enteral feeding tube administration

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: MCT Oil
Description: Liquid for oral (PO) or enteral feeding tube administration
Study: NCT05356533

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Drinking to Cope CBT skills
Description: Young adults who drink to cope with negative affect will receive 8 web-based modules with cognitive behavioral skills
Study: NCT05032092

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Next Generation Sequencing
Description: Molecular analysis of liquid biopsy.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Next Generation Sequencing
Description: Molecular analysis of tissue biopsy.
Study: NCT06321432

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intensive weight loss intervention
Description: Intensive weight loss intervention, incl. total meal replacements, behavioural support, and weight loss medication.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Usual care
Description: Usual care
Study: NCT05032092

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Biomarker Monitoring
Description: Biomarker Monitoring of study patients receiving matched therapy.
Study: NCT04803422

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Antibiotic
Description: The study aims to test whether oral antibiotics is non-inferior compared to intravenous antibiotics.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Antibiotic
Description: The study aims to test whether oral antibiotics is non-inferior compared to intravenous antibiotics.
Study: NCT05581641

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT165b1
Description: RNA vaccine for active immunization against malaria administered as intramuscular injection

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT05053217

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: transforaminal epidural steroid injection
Description: In the transforaminal approach, a small amount of drug is injected into the epidural space, and in previous studies, reduction in pain and improvement in functionality were found in patients with lumbar radicular pain in the short and medium term.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: transforaminal epidural steroid injection
Description: In the transforaminal approach, a small amount of drug is injected into the epidural space, and in previous studies, reduction in pain and improvement in functionality were found in patients with lumbar radicular pain in the short and medium term.
Study: NCT05095129

Intervention type: GENETIC
Intervention: SNP analysis of the DNA
Description: SNP analysis of the DNA obtained from peripheral blood sample

Intervention type: GENETIC
Intervention: SNP analysis of the DNA
Description: SNP analysis of the DNA obtained from peripheral blood sample
Study: NCT05969314

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cannabis capsules
Description: Cannabis capsules containing 5 mg of THC and CBD each or 2.5 mg of THC and CBD each.
Study: NCT04839042

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.M., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.M., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.M., single or multiple-dose
Study: NCT06357936

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: nano-fat grafting in chronic limb ischaemia
Description: The nano fat grafting procedure in the clinical trial involves the collection of adipose tissue under tumescent anesthesia, which is a technique to swell and firm the targeted area, through a separate puncture in the anterior abdominal wall. Following the collection, the adipose tissue undergoes a process of cannulation to prepare the nano fat. This prepared material is then injected into the tissues of the foot and leg using standard intramuscular injection needles. The injections are performed in various directions to ensure proper distribution of the nano fat. This method does not require additional drug therapy. It leverages the natural growth factors and stem cells present in adipose tissue, aiming to improve blood flow and tissue regeneration in limbs affected by critical ischemia. The unique aspect of this treatment is its focus on using autologous materials, minimizing the risk of rejection and side effects associated with foreign substances.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: sham comparator
Description: For the clinical trial, a sham procedure would be designed to mimic the nano fat grafting without providing the actual therapeutic intervention. This involve the patient undergoing a similar process with tumescent anesthesia and making a puncture on the anterior abdominal wall. However, instead of harvesting adipose tissue and preparing nano fat, a placebo solution (such as saline) would be injected using the same intramuscular injection technique. The aim of this sham comparator is to assess the psychological and physiological effects of the nano fat grafting procedure itself, by eliminating the potential therapeutic benefits of the nano fat.
Study: NCT04847778

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Use of Insulclock system, both Insulclock device and Insulclock 360 app.
Description: Visit 5, during week 4.~Randomization will be applied:~Active group will use all functionalities of Insulclock 360. They will have reminders, all their information and statistics at the disposition of the patient and healthcare providers, they have the assistance if desired of an ally or caregiver, a bolus calculator and the rest of functionalities described in the protocol.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Use of Insulclock system, both Insulclock device and Insulclock app on masked mode.
Description: Visit 5, during week 4.~Randomization will be applied:~Masked group will remain with the masked system, without functionalities.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Use of Insulclock system, both Insulclock device and Insulclock app on masked mode.
Description: Visit 5, during week 4.~Randomization will be applied:~Masked group will remain with the masked system, without functionalities.
Study: NCT05484349

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tizanidine Hydrochloride
Description: Tizanidine Hydrochloride 1 mg Tid for 12 consecutive weeks and were followed up for 12 weeks
Study: NCT04839042

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.M., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.M., single or multiple-dose
Study: NCT04719819

Intervention type: PROCEDURE
Intervention: Spinal anaesthesia for caesarean section
Description: Descriptive questionnaire with open and closed questions, to be completed during the procedure
Study: NCT05375617

Intervention type: OTHER
Intervention: Observational
Description: No intervention

Intervention type: OTHER
Intervention: Observational
Description: No intervention
Study: NCT04839042

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.M., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose
Study: NCT06646367

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional therapy
Description: All participants in the two groups will receive conventional therapy in the form of TENS and moist heat for 5 weeks.TENS will be applied 5 times a week for 5 weeks at a frequency of 80Hz with 10- to 30-mA intensity for 25 minutes. Four surface electrodes (5x5 cm each) were situated over the painful region in the neck (two electrodes will be placed in either side of the spine high on neck, just underneath the skull and the other two electrodes will be placed about 5cm underneath them) with intensity in the tactile sensation threshold. The hot packs will be applied for 30 minutes on the cervical area, 5 times per week for 5 weeks.
Study: NCT04839042

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.N., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.H., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.H., single or multiple-dose

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.H., single or multiple-dose
Study: NCT06646367

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conventional therapy
Description: All participants in the two groups will receive conventional therapy in the form of TENS and moist heat for 5 weeks.TENS will be applied 5 times a week for 5 weeks at a frequency of 80Hz with 10- to 30-mA intensity for 25 minutes. Four surface electrodes (5x5 cm each) were situated over the painful region in the neck (two electrodes will be placed in either side of the spine high on neck, just underneath the skull and the other two electrodes will be placed about 5cm underneath them) with intensity in the tactile sensation threshold. The hot packs will be applied for 30 minutes on the cervical area, 5 times per week for 5 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alexander technique
Description: Women in the experimental group will attend 10 Alexander Technique classes (60 minutes each, twice a week for 5 weeks). The Alexander Technique focuses on body awareness, reducing muscle tension, and improving coordination through three principles: enhanced awareness, purposeful inhibition, and mental imagery. Participants will learn to release habitual muscle tension and explore alternative movement patterns, covering biomechanics and ergonomics of the neck, spine, and limbs. The sessions involve hands-on guidance, verbal instruction, and group activities. Daily practice in a semi-supine position is encouraged to improve posture, coordination, and overall well-being.
Study: NCT05834361

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: early vaginal administration of carboprost methylate
Description: In this group, the administration time point of carboprost methylate is 20 minutes before the surgery.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: delayed vaginal administration of carboprost methylate
Description: In this group, the administration time point of carboprost methylate is usually 110-120 minutes before the surgery.
Study: NCT04839042

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SC-Ad6-1
Description: SC-Ad6-1, I.H., single or multiple-dose
Study: NCT05484349

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tizanidine Hydrochloride
Description: Tizanidine Hydrochloride 2 mg Tid for 12 consecutive weeks and were followed up for 12 weeks

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Tizanidine Hydrochloride Placebo
Description: Tizanidine Hydrochloride Placebo Comparator 1 tablet Tid for 12 consecutive weeks and were followed up for 12 weeks
Study: NCT06540664

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Auricular Acupuncture needles
Description: Auricular Acupuncture needles 5 days in 2 weeks
Study: NCT05228093

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Curative-intent endoscopic necrectomy followed by reconstruction using the posterior pedicle nasal septum and floor mucoperiosteum flap
Description: Radical endoscopic necrectomy was performed under general anesthesia using the endoscopic endonasal approach. And the reconstruction of the nasopharyngeal defect use the nasal septum and floor mucoperiosteum flap. Antibiotic therapy based on the result of bacterial cultivation before the surgery was administered for 5-7 days after surgery. Patients are prescribed regional perfusion with recombinant human epidermal growth factor derivative liquid (Watsin Genetech Ltd, Shenzhen, Guangdong, P.R. China) to keep the wound humid, and endoscopic nasal cleanup was performed every 2-4 weeks until the flap was completely epithelialized and the entire defect was relined.~Patients who were assessed as non-healing at 3 months after treatment will underwent salvage surgery.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Conservative treatment
Description: Debridement guided by nasopharyngeal endoscopy and excision of the radiation-induced necrotic tissues were performed every 1 or 2 weeks. Patients are prescribed regional perfusion with recombinant human epidermal growth factor derivative liquid (Watsin Genetech Ltd, Shenzhen, Guangdong, P.R. China) to keep the wound humid. Other conservative treatment included daily nasopharynx rinsing with 2% aquae hydrogeniidioxide (5-10 mL each time) or saline (50-100 mL each time) and antibiotic therapy (metronidazole or ornidazole) guided by the culture results was also performed synchronously. Intravenous nutrition and systematic antibiotic therapy were also performed if indicated and necessary. In addition, patients can receive hyperbaric oxygen therapy when conditions permit.~Patients who were assessed as non-healing at 3 months after treatment will underwent salvage surgery.
Study: NCT06540664

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham Auricular Acupuncture needles
Description: Sham Auricular Acupuncture needles 5 days in 2 weeks
Study: NCT06424275

Intervention type: DIAGNOSTIC_TEST
Intervention: Risk-based screening algorithm
Description: Risk-based screening algorithm

Intervention type: DIAGNOSTIC_TEST
Intervention: Risk-based screening algorithm
Description: Risk-based screening algorithm

Intervention type: DIAGNOSTIC_TEST
Intervention: Risk-based screening algorithm
Description: Risk-based screening algorithm

Intervention type: DIAGNOSTIC_TEST
Intervention: Risk-based screening algorithm
Description: Risk-based screening algorithm

Intervention type: DIAGNOSTIC_TEST
Intervention: Risk-based screening algorithm
Description: Risk-based screening algorithm
Study: NCT05098210

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Neoantigen Peptide Vaccine
Description: Given IM

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Nivolumab
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Poly ICLC
Description: Given IM

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Echocardiography
Description: Undergo ECHO

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Multigated Acquisition Scan
Description: Undergo MUGA

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: Undergo tumor biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT or PET/CT

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo PET or PET/CT