Study: NCT05840406

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with acetaminophen
Description: During the 24 hours postoperatively, participants will receive 1 g acetaminophen intravenously (i.v.) three times a day. On the second and third postoperative days, participants will receive 1g acetaminophen per os three times a day.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with acetaminophen
Description: During the 24 hours postoperatively, participants will receive 1 g acetaminophen intravenously (i.v.) three times a day. On the second and third postoperative days, participants will receive 1g acetaminophen per os three times a day.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Postoperative pain management with acetaminophen
Description: During the 24 hours postoperatively, participants will receive 1 g acetaminophen intravenously (i.v.) three times a day. On the second and third postoperative days, participants will receive 1g acetaminophen per os three times a day.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bilateral TAP Block with levobupivacaine
Description: Ultrasound-guided bilateral TAP block will be performed, and 20 ml of 0,25 % levobupivacaine will be administered to the participant on each side.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bilateral TAP Block with levobupivacaine and dexmedetomidine
Description: Ultrasound-guided bilateral TAP block will be performed, and 20 ml of 0,25 % levobupivacaine with the addition of 0,5 μg/kg dexmedetomidine will be administered to the participant on each side.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with tramadol
Description: During the 24 hours postoperatively, participants will receive 500 mg tramadol + 500 ml 0,9% NaCl i.v. continuously 30ml/h.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with tramadol
Description: During the 24 hours postoperatively, participants will receive 500 mg tramadol + 500 ml 0,9% NaCl i.v. continuously 30ml/h.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Postoperative pain management with tramadol
Description: During the 24 hours postoperatively, participants will receive 500 mg tramadol + 500 ml 0,9% NaCl i.v. continuously 30ml/h.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with ketoprofen
Description: During the 24 hours postoperatively, participants will receive 100 mg ketoprofen + 100 ml of 0,9% NaCl i.v. twice a day. The first dose will be administered in the theatre at the end of the surgical procedure.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with ketoprofen
Description: During the 24 hours postoperatively, participants will receive 100 mg ketoprofen + 100 ml of 0,9% NaCl i.v. twice a day. The first dose will be administered in the theatre at the end of the surgical procedure.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Postoperative pain management with ketoprofen
Description: During the 24 hours postoperatively, participants will receive 100 mg ketoprofen + 100 ml of 0,9% NaCl i.v. twice a day. The first dose will be administered in the theatre at the end of the surgical procedure.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with ibuprofen
Description: On the second and third postoperative days, participants will receive 600 mg ibuprofen per os three times a day.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Postoperative pain management with ibuprofen
Description: On the second and third postoperative days, participants will receive 600 mg ibuprofen per os three times a day.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Postoperative pain management with ibuprofen
Description: On the second and third postoperative days, participants will receive 600 mg ibuprofen per os three times a day.