TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06022328

Intervention type: BIOLOGICAL
Intervention: Assessment of the epigenetic age
Description: Retrospective assessment of the epigenetic age on DNA samples obtained at diagnosis

Intervention type: BIOLOGICAL
Intervention: Assessment of the epigenetic age
Description: Retrospective assessment of the epigenetic age on DNA samples obtained at diagnosis

Intervention type: BIOLOGICAL
Intervention: Assessment of the epigenetic age
Description: Retrospective assessment of the epigenetic age on DNA samples obtained at diagnosis

Intervention type: BIOLOGICAL
Intervention: Assessment of the epigenetic age
Description: Retrospective assessment of the epigenetic age on DNA samples obtained at diagnosis
Study: NCT05862051

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Local Ablative Therapy
Description: LAT modalities allowed include surgical resection, stereotactic radiotherapy (SRT), laparoscopic or percutaneous thermal ablation \[radiofrequency ablation (RFA) or microwave ablation (MWA)\]. The LAT modalities will be delivered by specialists in the field (surgeons, radiation oncologists and/or interventional radiologists). The precise mode of delivery and number of times the LAT modality is delivered is case-dependent and is determined at a multi-disciplinary meeting (MDM).

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Standard first-line systemic treatment
Description: Standard of care as determined by the treating clinician. The following standard chemotherapy regimens are allowed: single agent fluoropyrimidine, CAPOX, FOLFOX, FOLFIRI, CAPIRI or FOLFOXIRI. Treatment with a biologic is allowed including bevacizumab or an anti-EGFR antibody (cetuximab or panitumumab). For patients receiving a doublet or triplet regimen, treatment may be de-escalated to maintenance fluoropyrimidine +/- biologics or anti-EGFR monotherapy at any point after trial entry at clinician discretion.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard first-line systemic treatment
Description: Standard of care as determined by the treating clinician. The following standard chemotherapy regimens are allowed: single agent fluoropyrimidine, CAPOX, FOLFOX, FOLFIRI, CAPIRI or FOLFOXIRI. Treatment with a biologic is allowed including bevacizumab or an anti-EGFR antibody (cetuximab or panitumumab). For patients receiving a doublet or triplet regimen, treatment may be de-escalated to maintenance fluoropyrimidine +/- biologics or anti-EGFR monotherapy at any point after trial entry at clinician discretion.
Study: NCT06281795

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: tVNS
Description: tVNS will be performed daily after workouts for 60 minutes over a period of 8 weeks.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: tVNS
Description: tVNS will be performed daily after workouts for 60 minutes over a period of 8 weeks.
Study: NCT06195644

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Galvanic vestibular stimulation
Description: galvanic current generated by Gymna DUO 200 and delivered through conductive medium (electrode gel) by two small carbon rubber electrodes 3 cm 2 each bilaterally over two mastoid processes for 30 minutes, two times per week for 12 weeks .

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: MovAlyzeR® software from Neuroscript
Description: MovAlyzeR® movement analysis software from Neuroscript turns a pen tablet or mouse into a high-quality system for examining movements by a pen, mouse or finger. Hence, it can train and analyze hand dexterity and handwriting using pen tablets such as sentence parameters.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MovAlyzeR® software from Neuroscript
Description: MovAlyzeR® movement analysis software from Neuroscript turns a pen tablet or mouse into a high-quality system for examining movements by a pen, mouse or finger. Hence, it can train and analyze hand dexterity and handwriting using pen tablets such as sentence parameters.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: BODYFIT Mini Portable Pedal Home Exerciser (cyclic ergometer)
Description: stationary upper body pedaling as a moderate intensity aerobic training

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: BODYFIT Mini Portable Pedal Home Exerciser (cyclic ergometer)
Description: stationary upper body pedaling as a moderate intensity aerobic training
Study: NCT05671627

Intervention type: DRUG
Intervention: DMARDs
Description: Patients will be treated as per clinician's judgement with any kind or combination of DMARDs with or without corticosteroids (corticosteroid regimens do not exceed 15 mg/day), following EULAR recommendations for RA treatment.

Intervention type: DRUG
Intervention: DMARDs
Description: Patients will be treated as per clinician's judgement with any kind or combination of DMARDs with or without corticosteroids (corticosteroid regimens do not exceed 15 mg/day), following EULAR recommendations for RA treatment.
Study: NCT05829499

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: HPMC-HA eyedrops
Description: Ocular drops based upon HPMC and HA
Study: NCT05427500

Intervention type: DRUG
Group type: OTHER
Intervention: 5 mL of 0.5% preservative-free bupivacaine
Description: IV will be inserted. Patient will be connected to cardiorespiratory monitors. The neck will be cleansed twice. A high frequency (15-6 MHz) linear ultrasound probe will be used to identify the arteries, jugular vein, and other important vasculature. Once a clear path for the needle is identified, the skin is anesthetized. A cutting tip spinal needle is then inserted at the lateral aspect of the field and advanced in-plane under ultrasound visualization. A test injection is injected to verify placement, then 5 mL of 0.5% preservative-free bupivacaine will be injected. Per standard SGB procedure, vitals will be measured post-SGB and participants will remain in the clinic for approximately 15 minutes to monitor for any serious adverse events.
Study: NCT05211440

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo + Meal
Description: Subjects will be directed to consume 1 placebo capsule containing maltodextrin, twice daily, for 21 days. Subjects will be directed to consume the capsules with their two largest meals, in between the third and second bites of food. During the MMTT, a placebo capsule will be consumed with a standardized test meal containing chicken, peas, potatoes, and butter.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: BC-006 + Meal
Description: Subjects will be directed to consume 1 capsule containing BC-006, twice daily, for 21 days. Subjects will be directed to consume the capsules with their two largest meals, in between the third and second bites of food. During the MMTT, a BC-006 capsule will be consumed with a standardized test meal containing chicken, peas, potatoes, and butter.
Study: NCT06612021

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Beautibond universal adhesive
Description: HEMA free universal adhesive

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Tetric N universal bond
Description: HEMA containing universal bond
Study: NCT05849038

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib
Description: Patients will receive baricitinib at a dose of 2 mg oral daily.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: A placebo is a sugar pill that has no therapeutic effect and will be administered orally. Participants will receive 1 placebo tablet matching the baricitinib tablet.
Study: NCT04748289

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ICU Cockpit software testing
Description: the ICU Cockpit Software Platform is intended to be used for monitoring of patient characteristics and vital physiological parameters in patients at the Neurointensive Care Unit of the University Hospital Zurich.~Furthermore, three different applications for prognostication and prediction of complications will be tested:~1. ICU Cockpit COVID-19 for remote monitoring of isolated patients,~2. ICU Cockpit Stable State for a comprehensive visualization of vital parameters and as additional aid in early detection of imminent critical complications~3. ICU Cockpit Cerebral Ischemia for the prediction of delayed DCI in patients with subarachnoid hemorrhage (SAH).
Study: NCT06204497

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Stent-based Diverting Technique
Description: The stent-based diverting technique (SDT) contains two parts to achieve feces diversion One is a degradable solid intestinal stent to be implanted 20 cm from the terminal ileum and could be gradually degraded within 3-4 weeks. Another part is a drainage tube to be placed at the proximal 5-10 cm of the aforementioned stent. Given this SDT, intestinal contents could be diverted through the drainage tube, and the stent prevents the feces from entering the distal intestinal. After removing the drainage tube after 3-4 weeks, intestinal contents will freely access the distal intestinal space following the degradation of the stent. For patients, stoma reversal is avoided.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Stent-based Diverting Technique
Description: The stent-based diverting technique (SDT) contains two parts to achieve feces diversion One is a degradable solid intestinal stent to be implanted 20 cm from the terminal ileum and could be gradually degraded within 3-4 weeks. Another part is a drainage tube to be placed at the proximal 5-10 cm of the aforementioned stent. Given this SDT, intestinal contents could be diverted through the drainage tube, and the stent prevents the feces from entering the distal intestinal. After removing the drainage tube after 3-4 weeks, intestinal contents will freely access the distal intestinal space following the degradation of the stent. For patients, stoma reversal is avoided.
Study: NCT04864054

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ECT204 T cells
Description: ECT204 is an autologous T-cell therapy whereby a subject's own T cells are transduced with a lentiviral vector expressing the ECT204 transgene.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ECT204 T cells
Description: ECT204 is an autologous T-cell therapy whereby a subject's own T cells are transduced with a lentiviral vector expressing the ECT204 transgene.
Study: NCT05358899

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: accelerated theta burst stimulation
Description: cTBS was administered at 80% of each participant's M1 area in a burst-firing pattern (3 pulses at 50 Hz) with a repetition frequency of 5 Hz (200 ms intervals). During each session, participants received 1800 pulses (120 s).

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham stimulation
Description: Similar process with the accelerated theta burst stimulation with the coil 90 degrees tilted to the surface of the scalp, which could produce identical sound and vibration while avoiding real magnetic stimulation.
Study: NCT05702437

Intervention type: OTHER
Intervention: assessment of cognitive performance
Description: evaluation of the cognitive and physical performance of the participants by two separate researchers at the same time

Intervention type: OTHER
Intervention: assessment of cognitive performance
Description: evaluation of the cognitive and physical performance of the participants by two separate researchers at the same time
Study: NCT05721664

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Trianing program for nurse in how to provide evidence based practices for mechanically Ventilated Patients
Description: Short Name: (EBNPTP) for Caring of Mechanically Ventilated Patients in terms of standardized care.~Duration: Two weeks A number of Contact Hours: 30 hrs. associated arm (interventional arm): for study group of ICU Nurses working at National Hepatology and Tropical Medicine Research Institute (NHTMRI)

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Trianing program for nurse in how to provide evidence based practices for mechanically Ventilated Patients
Description: Short Name: (EBNPTP) for Caring of Mechanically Ventilated Patients in terms of standardized care.~Duration: Two weeks A number of Contact Hours: 30 hrs. associated arm (interventional arm): for study group of ICU Nurses working at National Hepatology and Tropical Medicine Research Institute (NHTMRI)
Study: NCT05538013

Intervention type: OTHER
Intervention: Survey evaluation
Description: Obesity awareness, physical activity, and sedentary time questionnaires will be applied to these cases.
Study: NCT04708158

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Novaferon
Description: a novel recombinant antiviral protein drug

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Saline
Study: NCT05719896

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DT01 tablets
Description: Each subject was given orally 3 DT01 tablets/day for 8 weeks

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo tablets
Description: Each subject was given orally 3 DT01 tablets/day for 8 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DT01-Placebo tablets
Description: Each subject was given orally 2 DT01 tablets and 1 Placebo tablet, three times per day for 8 weeks
Study: NCT06459310

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin Hydrochloride tablet
Description: Extended release oral tablets, 1000 mg/day, single dose

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Oral tablets, 1000 mg/day, single dose
Study: NCT05235932

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Robotic radical total gastrectomy with D2 lymphadenectomy
Description: Most surgical procedures are performed using the robot system.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Laparoscopic radical total gastrectomy with D2 lymphadenectomy
Description: Without the robot system, Most surgical procedures are performed using laparoscopic equipment.
Study: NCT04864054

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Regorafenib (STIVARGA®, BAY73-4506)
Description: Regorafenib pretreatment before an ECT204 infusion.
Study: NCT06102317

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: nursing consultancy with smartphone support
Description: In the study, mobile application will be installed on the phones of the mothers in the initiative group and individual information will be provided about how the patients will use the smartphone application. . Information will be provided to patients for subsequent follow-ups. After the application is started to be used, notifications of the applications developed in Smart Mobile for the disease management process will be made to the mothers of the Initiative Group every two weeks for six months. In addition, the Initiative Group will continue to receive standard care practices such as examinations, examinations, tests, treatment, medical care and rehabilitation offered by the Home Health Services unit.
Study: NCT05415189

Intervention type: OTHER
Intervention: Not relevant
Description: This is a non-intervention cohort study

Intervention type: OTHER
Intervention: Not relevant
Description: This is a non-intervention cohort study
Study: NCT05362708

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Clinical - Hypnosis with VR (VRH)
Description: The VRH intervention will use the Aqua video session developed by Oncomfort during a port-a-cath procedure.
Study: NCT05240235

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Education, compression and exercise therapy
Description: Education; It includes information about the disease, information about risk factors, information that one should pay attention to, and skin care. For compression, sponge-shaped pads that create compression into the bra and prepared by the lymphedema physiotherapist will be used. The exercises will include breathing and upper extremity joint movement exercises determined by Casley-Smith, and the other days to be applied by the physiotherapist when the patient comes to the session will be applied by the patient once a day at home.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Education, compression and exercise therapy manual lymph drainage
Description: Education; It includes information about the disease, information about risk factors, information that one should pay attention to, and skin care. For compression, sponge-shaped pads that create compression into the bra and prepared by the lymphedema physiotherapist will be used. The exercises will include breathing and upper extremity joint movement exercises determined by Casley-Smith, and the other days to be applied by the physiotherapist when the patient comes to the session will be applied by the patient once a day at home. In addition, patients will be given manual lymph drainage for one and a half hours every day for the first two weeks. Afterwards, patients will be taken to the same therapy in the hospital for 1 day a week, and on other days they will do self manual lymph drainage at home for 10 minutes.
Study: NCT05988762

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supramaximal Walkout
Description: Walkout set performed at 110% 1RM. Participant will unrack the weight, step back and brace as if to perform a back squat, hold for 10 seconds, then re-rack the weight without performing the squat.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Submaximal Walkout
Description: Walkout set performed at 30% 1RM. Participant will unrack the weight, step back and brace as if to perform a back squat, hold for 10 seconds, then re-rack the weight without performing the squat.
Study: NCT06234540

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PRP
Description: a-PRP intrauterine instillation before frozen-thawed embryo transfer cycle

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PRP
Description: a-PRP intrauterine instillation before frozen-thawed embryo transfer cycle

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard treatment
Description: Standard treatment
Study: NCT05497752

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: cervical rehabilitation program
Description: (Positional release technique on trapezius muscle): The subject was supine The therapist applied Pressure by pinching the trapezius muscle between the thumb and fingers.~Suboccipital muscle release):~The patient will be in a Supine lying position therapist places both his palms at suboccipital region with upward pressure causing a stretch and distraction for 30 seconds. This technique was performed 3 times in one session with a rest interval of 1 minute after each time.~(Stretching of pectoralis muscle):. once daily Stretching with repetition of five, three times a day for 1week

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: control group
Description: Relax shoulders and neck sufficiently look down turn face to the right turn face to the left incline head to the right incline head to the left turn shoulders round and round slowly raise hands fully then lower them. patients were asked to perform five repetitions of each stretching exercise, three times per day (morning, afternoon, and evening).
Study: NCT05252403

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: PTG-CARCIK-CD19
Description: PTG-CARCIK-CD19 cells is a gene therapy medicinal product (GTMP) composed of genetically modified allogeneic T lymphocytes formulated as cell suspension in normal saline solution and freezing media
Study: NCT05163769

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: NeeuroCycle Physical and Cognitive Training System
Description: The NeeuroCycle Physical and Cognitive Training System is a novel multimodal electroencephalogram (EEG)-based physical and cognitive training device. The system mainly comprises of a recumbent bicycle device and a customized four frontal electrode EEG-headband paired with the gamified NeeuroCycle cognitive training program delivered via an electronic application (app) on a tablet. The cognitive training program is built upon patented EEG-based attention, learning, and memory algorithms.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: NeeuroCycle Cognitive Training System
Description: The NeeuroCycle Cognitive Training System is a novel electroencephalogram (EEG)-based cognitive training device. The system mainly comprises of a customized four frontal electrode EEG-headband paired with the gamified NeeuroCycle cognitive training program delivered via an electronic application (app) on a tablet. The cognitive training program is built upon patented EEG-based attention, learning, and memory algorithms.
Study: NCT05633433

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azvudine
Description: Azvudine is a novel nucleoside reverse transcriptase inhibitor.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azvudine
Description: Azvudine is a novel nucleoside reverse transcriptase inhibitor.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azvudine
Description: Azvudine is a novel nucleoside reverse transcriptase inhibitor.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06379373

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Spine manipulation; westren medicine
Description: First Cervical traction,than spine release method,Massage the neck for about 10 minutes to realease muscles.Doctor use his two hands work together to pull the neck forward and upward,meanwhile, the patient's head is passively rotated to the right to the maximum, being rotated slightly with appropriate force, Doctor's left thumb pushes the crooked spinous process to the right, and the reduction sound can be heard at this time.~If patient has upper thoracic spine misalignment, the dislocated segment needs to be adjusted.~If patient has scoliosis, the affected spine segment should also be adjusted. If patient's lumbar facet joints are misaligned, or one of the lumbar muscles is spasmal, also the disorder joints need to be adjusted.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Spine manipulation; westren medicine
Description: First Cervical traction,than spine release method,Massage the neck for about 10 minutes to realease muscles.Doctor use his two hands work together to pull the neck forward and upward,meanwhile, the patient's head is passively rotated to the right to the maximum, being rotated slightly with appropriate force, Doctor's left thumb pushes the crooked spinous process to the right, and the reduction sound can be heard at this time.~If patient has upper thoracic spine misalignment, the dislocated segment needs to be adjusted.~If patient has scoliosis, the affected spine segment should also be adjusted. If patient's lumbar facet joints are misaligned, or one of the lumbar muscles is spasmal, also the disorder joints need to be adjusted.