TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05897307

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Ropivacaine
Description: dexmedetomidine
Study: NCT05200468

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ketogenic diet
Description: Weekly menus will be delivered according to diet with the following macronutrient distribution: 25% protein, 10% carbohydrate, 65% fat. Participants will receive a 30-day food menu guide.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Caloric restriction diet
Description: Weekly menus will be provided according to their usual diet with 500 kcal restriction with the following macronutrient distribution 25-35% protein, 45-55% carbohydrates, 20-30% fat. Participants will receive a 30-day food menu guide.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intermittent fasting 16/8
Description: Calorie-restricted menus will be provided with a 16:8 time-restricted feeding. The feeding window will be 8 hours with a fasting time of 16 hours (04.00 pm- 08.00 am or 05.00 pm - 09.00 am), during the fasting window participants will only be allowed to drink water, unsweetened tea, mineral water and coffee without added sugar. Participants will receive a 30-day food menu guide.
Study: NCT06264336

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: treadmill training
Description: Participants will undergo 12 sessions (4 weeks, 3 sessions/week) of treadmill training. During each session, participants will walk for 40 min. with 5 min. of warmup and cooldown at 50% of maximal walking speed (tested each week) with 30 min. of training interposed. The type of training will be determined by the assigned treatment arm.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: treadmill training
Description: Participants will undergo 12 sessions (4 weeks, 3 sessions/week) of treadmill training. During each session, participants will walk for 40 min. with 5 min. of warmup and cooldown at 50% of maximal walking speed (tested each week) with 30 min. of training interposed. The type of training will be determined by the assigned treatment arm.
Study: NCT05897307

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ropivacaine
Description: dexmedetomidine

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ropivacaine
Description: dexmedetomidine
Study: NCT04927845

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: StriveWeekly
Description: The intervention (app.striveweekly.com) delivers content via independent modules. Principles covered in content modules: Psychoeducation; Self-monitoring; Values-based goal-setting; Behavioral activation; Cognitive restructuring; Sleep hygiene; Time management; Interpersonal avoidance exposures; Physical exercise; Mindfulness; Relaxation strategies; Maintenance planning. Modules get released week-by-week, and participants are self-guided through content. To facilitate skills practice, every module is accompanied by: a weekly intro email and reminder emails; an extras section for tips/suggestions; and a weekly prize drawing. The Dashboard section of the intervention displays user progress, including self-rating graphs and a history log of skills practice. The Campus section of this dashboard provided: campus-specific announcements; referrals to relevant campus wellness resources; and an anonymous livestream of all campus users' activity.
Study: NCT06453291

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NSAIDs (Nonsteroidal Anti-Inflammatory Drugs):
Description: Objective: To reduce pain and inflammation associated with chronic low back pain.~Medications: Ibuprofen, Naproxen, or Diclofenac.~Dosage:~Ibuprofen: 400-600 mg every 6-8 hours as needed. Naproxen: 250-500 mg twice daily as needed. Diclofenac: 50 mg three times daily as needed. Administration: Oral tablets. Duration: Daily use as prescribed, for the duration of the study. Monitoring: Regular follow-up visits to monitor pain levels, side effects, and adherence.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard Physical Therapy
Description: Objective: To improve mobility, strength, and reduce pain.~Techniques:~Stretching exercises. Strengthening exercises for core and back muscles. Manual therapy techniques. Postural training. Frequency: Twice a week sessions. Duration: 45-60 minutes per session. Monitoring: Progress will be assessed during each session and adjusted as necessary
Study: NCT06037005

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy Group
Description: Group intervention program based on cognitive behavioral approach of ten sessions; It was completed in approximately one and a half months (May-June 2022) in the Faculty of Nursing, by dividing the experimental group into two separate groups, two days a week for each group. Each session was held for approximately one hour. The last measurement was made three months after the last therapy session (September 2022).
Study: NCT05734040

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: OVX836 480µg
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: OVX836 480µg
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: OVX836 480µg
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Fluarix Tetra
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Fluarix Tetra
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Afluria Quad
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Afluria Quad
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: One single administration intramuscularly at Day 1

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: One single administration intramuscularly at Day 1
Study: NCT04854603

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Dairy products with regular and reduced sugar content and water control.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Dairy products with regular and reduced sugar content and water control.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Dairy products with regular and reduced sugar content and water control.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Dairy products with regular and reduced sugar content and water control.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Dairy products with regular and reduced sugar content and water control.
Study: NCT05142280

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Decision-aid for cardiovascular disease risk
Description: The active choice intervention aims to promote an active choice regarding coping with an increased risk of cardiovascular disease. This means that individuals should (a) become aware of a discrepancy between the current and desired situation; (b) understand what the CVD risk means, and what its causes and consequences are; (c) evaluate the pros and cons of the different options to cope with the risk; and (d) are clear about their values regarding the choice.

Intervention type: OTHER
Group type: OTHER
Intervention: Control
Description: The control condition contains information that resembles usual care by a GP regarding CVD prevention
Study: NCT04941326

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Diaphragmatic stimulation treatment with PNF techniques
Description: Thumbs and palms are placed along the cartilage edges of the lower ribs. At the end of the expiration, pressure and stretching are given as far into the chest and upwards as possible and a deep inspiration is requested immediately after the pressure. Both sides can be stimulated by repeated contraction technique. Hand holding positions may differ according to the patient's preference. If the patient's physical condition is not suitable, the application can be done with the thumbs, the thumb of the left hand for the right rib, and the thumb of the right hand for the left rib in the same lying position. The patient will be asked to do the application 2 times in a day with 10 repetitions for 4 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Diaphragmatic stimulation treatment with PNF techniques
Description: Thumbs and palms are placed along the cartilage edges of the lower ribs. At the end of the expiration, pressure and stretching are given as far into the chest and upwards as possible and a deep inspiration is requested immediately after the pressure. Both sides can be stimulated by repeated contraction technique. Hand holding positions may differ according to the patient's preference. If the patient's physical condition is not suitable, the application can be done with the thumbs, the thumb of the left hand for the right rib, and the thumb of the right hand for the left rib in the same lying position. The patient will be asked to do the application 2 times in a day with 10 repetitions for 4 weeks.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Costal mobilization
Description: In the supine position, the individual will place both hands around the 10-12th ribs and alternately apply an oblique push from the right and left sides to the opposite side. The exercise will be taught to the patient as training, and he will be asked to apply it 2 times a day with 20 repetitions for 4 weeks.
Study: NCT05577572

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotics packets
Description: The treatment period is designed for 56 days: Bismuth containing quadruple therapy is performed from day 1\~10 and Probiotics packets is taken from day 1\~56.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo packets
Description: The treatment period is designed for 56 days: Bismuth containing quadruple therapy is performed from day 1\~10 and Placebo packets is taken from day 1\~56.
Study: NCT06453291

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Neuromodulation via Dorsal Root Ganglion (DRG):
Description: Objective: To modulate excitatory pathways and reduce pain through targeted stimulation.~Procedure:~Placement of electrodes near the DRG. Application of pulsed radiofrequency (RF) at 42°C for 3-20 minutes.~Frequency:~Initial treatment: Once a week for the first month. Maintenance: Monthly sessions if needed. Duration: Each session lasts approximately 30-45 minutes. Monitoring: Pain levels and functional improvement will be assessed before and after each session.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Platelet-Rich-Plasma Therapy
Description: Objective: To promote healing and reduce inflammation through the application of concentrated platelets.~Procedure:~Blood draw from the patient. Centrifugation to separate platelets. Injection of PRP into the affected area of the lower back.~Frequency:~Initial treatment: Once a week for the first three weeks. Follow-up: Additional injections may be given based on patient response and clinical judgment.~Duration: Each session lasts approximately 30-45 minutes. Monitoring: Pain levels, inflammation markers, and functional improvement will be assessed before and after each injection.
Study: NCT06426849

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Liuzijue Exercise
Description: LiuzijueExercise includes inhalation and exhalation through various mouth patterns to manage and control the rise and fall of the breath in the body. It is performed by delivering 6 distinct sounds, (xū,hē, hū sī, chuī, and xī) through termination along with comparing body activities.~The following are 6-8 vital parts of body movements:~1. Swaying and twisting~2. Hip rotations~3. Arm movements~4. Knee bends~5. Foot pivots~6. Spine elongation~7. Hand gestures~8. Breath synchronization Frequency: 1 session per day for a week Intensity:In first week 1 set of Luizijue exercise will be performed then progressively increase to 4 sets till 6th week .~Total Time for Session; 40 minutes Warm-up Time: 10 minutes with pursed lip breathing Cool Down Time: 10 minutes with upper body gentle stretching. Exercise Duration: 20 minutes for Luizijue Exercise.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Tai Chi Chuan Exercise
Description: Tai Chi Chuan Exercise combines deep diaphragmatic breathing and relaxation with many fundamental postures.~Names of the 10 Movements in Sequence~1. Commencing Form~2. Repulsing the Monkey~3. Brush Knee~4. Parting the Horse's Mane~5. Cloud Hands~6. Golden Cockerel Standing on the Left, then the Right~7. Kick Out Right, Kick Out Left~8. Grasping the Bird's Tail~9. Cross Hands or Embrace the Tiger~10. Closing Form Frequency: 3 sessions / week Intensity: Initially each posture will be performed 3 times then progressively leads to 6 or 10 reps according to patient tolorance.~Total Time for Session; 40 minutes Warm-up Time: 10 minutes with pursed lip breathing Cool Down Time: 10 minutes with upper body gentle stretching. Exercise Duration: 20 minutes for Tai Chi Chuan Exercise.
Study: NCT05348486

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Dose escalation
Description: Dose escalation 75,9 - 79,2 Gy in 33 fractions for GTV hypoxic or any hypoxic LN \> 2cm
Study: NCT05755568

Intervention type: OTHER
Intervention: No Intervention
Description: As this is an observational study, no intervention will be administered.
Study: NCT04941326

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Costal mobilization
Description: In the supine position, the individual will place both hands around the 10-12th ribs and alternately apply an oblique push from the right and left sides to the opposite side. The exercise will be taught to the patient as training, and he will be asked to apply it 2 times a day with 20 repetitions for 4 weeks.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Breathing exercises
Description: It is done to increase the diaphragm activity of the individual and to suppress chest breathing. While lying in the supine position, the legs are placed in a hooked position, with one hand on the abdomen and the other on the chest, and the deep breath that is taken from the nose in 2 seconds is asked to exhale through the mouth in 4 seconds, while revealing as little movement in the chest as possible, the main movement is requested to be around the abdomen. The application will be given to the patient as a home program and he will be asked to do it 2 times a day with 5 repetitions for 4 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Breathing exercises
Description: It is done to increase the diaphragm activity of the individual and to suppress chest breathing. While lying in the supine position, the legs are placed in a hooked position, with one hand on the abdomen and the other on the chest, and the deep breath that is taken from the nose in 2 seconds is asked to exhale through the mouth in 4 seconds, while revealing as little movement in the chest as possible, the main movement is requested to be around the abdomen. The application will be given to the patient as a home program and he will be asked to do it 2 times a day with 5 repetitions for 4 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Spinal mobilization
Description: T12 vertebrae will be found by following the 12th rib in the prone position of the individual and spinous of L1 and L2 vertebrae will be determined with this reference. Then, small amplitude rotational movements in the vertebrae will be revealed by pushing in the anterior direction over the transverse processes. This application will be applied once a week for an average of 10 minutes for 4 weeks.
Study: NCT05449054

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Anterior colporrhaphy
Description: All patients will be operated by the vaginal route. They are prepared under strict aseptic conditions in the dorsal lithotomy position. The bladder is emptied preoperatively with a thin disposable catheter and antibiotic prophylaxis (cefazolin) is administered before incision. A vasoconstricting solution (combination of vasopression and NaCl) is administered and a vertical anterior vaginal incision is made from the apex to two centimeters short of the external urethral meatus using an electric cautery or a scalpel. The vaginal epithelium is grasped on both sides and the fibromuscular layer of the anterior vaginal wall is sharply dissected laterally to the inferior pubic ramus. The bladder is completely dissected from the apex and up to 4 to 6 cm from the pubic ramus. The anterior colporrhaphy is defined as a native tissue repair and rows of absorbable sutures (2/0 vicryl) are used.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Anterior colporrhaphy
Description: All patients will be operated by the vaginal route. They are prepared under strict aseptic conditions in the dorsal lithotomy position. The bladder is emptied preoperatively with a thin disposable catheter and antibiotic prophylaxis (cefazolin) is administered before incision. A vasoconstricting solution (combination of vasopression and NaCl) is administered and a vertical anterior vaginal incision is made from the apex to two centimeters short of the external urethral meatus using an electric cautery or a scalpel. The vaginal epithelium is grasped on both sides and the fibromuscular layer of the anterior vaginal wall is sharply dissected laterally to the inferior pubic ramus. The bladder is completely dissected from the apex and up to 4 to 6 cm from the pubic ramus. The anterior colporrhaphy is defined as a native tissue repair and rows of absorbable sutures (2/0 vicryl) are used.
Study: NCT04941326

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham mobilization
Description: Sham pressures will be applied to the lumbar region of the patient, away from the vertebrae. This application will be applied once a week for an average of 10 minutes for 4 weeks.
Study: NCT04779879

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Sotrovimab (Gen1)
Description: Participants will be randomized to receive an IV infusion of Sotrovimab Gen 1 material

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Sotrovimab (Gen2)
Description: Participants will be randomized to receive Sotrovimab Gen2 material by IV infusion or by IM injection

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Sotrovimab (Gen2)
Description: Participants will be randomized to receive Sotrovimab Gen2 material by IV infusion
Study: NCT06032000

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: LEM-mR203
Description: mRNA vaccine using Lemonex's Drug Delivery System (DDS), DegradaBALL

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% Sodium Chloride Solution
Study: NCT05419076

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Radiosurgery
Description: All participants will undergo MSK standard SRS. A CT simulation will be performed per institutional standards, typically with contrast unless a contraindication exists. A contrast-enhanced MRI with 1mm slices will be fused to the CT simulation scan for the purposes of SRS planning. The SRS GTV will be considered the visible tumor on MRI and CT contrast enhanced studies. An expansion of 1-2mm will be used to create the PTV. Radiation dose may be between 16Gy and 30Gy in 1 to 5 fractions, per the discretion of the treating radiation oncologist. Participants with multiple lesions may receive different doses to each lesion per the discretion of the treating radiation oncologist. Concurrent treatment to other body sites is permitted.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cerebrospinal fluid collection
Description: All participants will undergo lumbar puncture for CSF collection at study enrollment.. Lumbar punctures will be performed by clinical staff in neurology or neuroradiology, per the discretion of the treating radiation oncologist, as dictated by scheduling limitations and expected clinical difficulty in obtaining a sample (e.g. requiring fluoroscopic guidance), with input from the PI, neurology, and/or neuroradiology as necessary. Participants will be encouraged to undergo repeat lumbar puncture for CSF collection at 3 months (+/- 4 weeks), and at the time of CNS disease progression, though these latter timepoints are not required. CSF cytology will be evaluated.
Study: NCT04703114

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Blood count
Description: Blood count at each visit

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Blood count
Description: Blood count at each visit

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Blood collection
Description: Blood collection to understanding of the immunological profile at each visit

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Blood collection
Description: Blood collection to understanding of the immunological profile at each visit

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Nasopharyngeal swab
Description: Research of SARS-CoV-2 infection in nasopharyngeal swab by RT-PCR at day 8 and day 15
Study: NCT06583811

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Remifentanil
Description: to compare remifentanil and remimazolam to limit patient movement during long-eye surgeries under local anesthesia.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Remifentanil
Description: to compare remifentanil and remimazolam to limit patient movement during long-eye surgeries under local anesthesia.