TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05806567

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Belumosudil
Description: Pharmaceutical form: Tablet; Route of administration: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Belumosudil
Description: Pharmaceutical form: Tablet; Route of administration: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Belumosudil
Description: Pharmaceutical form: Tablet; Route of administration: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: UGT1A1 victim drug
Description: Pharmaceutical form: Tablet; Route of administration: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: P-gp victim drug
Description: Pharmaceutical form: Capsule; Route of administration: Oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: OATP1B1/BCRP victim drug
Description: Pharmaceutical form: Tablet; Route of administration: Oral
Study: NCT05051605

Intervention type: BIOLOGICAL
Intervention: COVID-19 Vaccine
Description: Severe acute respiratory syndrome- coronavirus-2 (SARS-CoV-2)vaccine according to vaccine availability in the Egyptian ministry of health.
Study: NCT06136481

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cognitive Processing Therapy
Description: Cognitive Processing Therapy (CPT). CPT is a cognitive behavioral treatment for PTSD consisting of 12 one-hour sessions. Prior to engaging in therapy, one session will be devoted to gathering information regarding psychosocial history, trauma, and current functioning. The following sessions will follow the standard outpatient CPT protocol. The standard outpatient CPT consists of 12 one-hour sessions conducted over a 6- to 12-week period. An additional 3 weeks will be provided in case of participant and therapist vacation and/or sick days. CPT is delivered in three phases: education, processing, and challenging. The manualized treatment focuses on challenging beliefs and assumptions related to the trauma, oneself, and the world.
Study: NCT04973059

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: SmartDrive Summer
Description: The SmartDrive is a power assist accessory for a manual wheelchair

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: SmartDrive Winter
Description: The SmartDrive is a power assist accessory for a manual wheelchair
Study: NCT05490602

Intervention type: PROCEDURE
Intervention: Running subcutaneous sutures technique
Description: The Running subcutaneous sutures consist of running sutures in the profound and superficial dermis without knotting the thread (suture).

Intervention type: PROCEDURE
Intervention: Classical closures
Description: Classical closures
Study: NCT01596153

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Go Live
Description: Enhanced Probiotic, one packet bid until 7 days after discontinuation of antibiotic

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Go Live
Description: Enhanced Probiotic, one packet bid until 7 days after discontinuation of antibiotic
Study: NCT04995653

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vancomycin Pre-Treatment
Description: Four times daily dosing with Vancomycin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vancomycin Pre-Treatment
Description: Four times daily dosing with Vancomycin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vancomycin Placebo
Description: Four times daily dosing with Vancomycin Placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SER-155
Description: Once daily dosing with SER-155

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SER-155
Description: Once daily dosing with SER-155

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SER-155 Placebo
Description: Once daily dosing with SER-155 placebo
Study: NCT06002529

Intervention type: OTHER
Group type: OTHER
Intervention: HFR
Description: patient received HFR treatment
Study: NCT04891211

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Vitamin D deficiency
Description: Ocular significance of vitamin D deficiency in pediatric cases
Study: NCT05073328

Intervention type: OTHER
Intervention: COVID-19 required hospitalisation
Description: Patients who contracted a COVID19 required hospitalisation

Intervention type: OTHER
Intervention: COVID-19 required hospitalisation
Description: Patients who contracted a COVID19 required hospitalisation

Intervention type: OTHER
Intervention: COVID-19 required hospitalisation
Description: Patients who contracted a COVID19 required hospitalisation
Study: NCT06660745

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: telenursing-based family empowerment program
Description: The intervention was conducted in two sections. The first part included a one-day educational workshop conducted through Skype for the child and their caregiver and was planned to introduce the members of the intervention group to each other and provide information on how to deliver and receive the content. In the second part of the intervention, the content was prepared based on a scheduled plan. It was in the form of a 5-10-minute audio file, video, or educational text and was uploaded on the SendBig website. Once the upload is complete, a link is provided to the user. The link was sent to the phone numbers of children with cystic fibrosis and their caregivers so that they could watch the weekly content over three months. Once it was confirmed that the link had been received (acknowledged in the Cystic Fibrosis Companions group) and the content had been viewed, remote follow-ups were scheduled twice a week, on Sundays and Tuesdays between 6:00 PM and 8:00 PM, using Skype messenger.
Study: NCT06602349

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lidocaine 10 MG/ML
Description: administration of lidocaine in posterior perineal block infiltration

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: administration of salin solution in posterior perineal block infiltration
Study: NCT06617728

Intervention type: PROCEDURE
Intervention: Intervention 1: Regional Analgesia
Description: Regional analgesia techniques like epidural or peripheral nerve blocks.

Intervention type: DRUG
Intervention: Intervention 2: Intravenous (IV) Analgesia
Description: IV medications used for pain control, including opioids and non-opioid analgesics.
Study: NCT06016569

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Exhaled breath condensate sampling
Description: Patient will breath for approx. 10 minutes to a breath condenser. The exhaled breath sample will be condensed and freezed.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Blood sampling
Description: A venous blood sample will be taken for further biomarker analysis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: LDCT
Description: LDCT scan will be performed.
Study: NCT05348343

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: Autologous platelet-rich plasma
Description: PRP created using a commercially available system will be used for treatment. PEFA-PRP will be created by subjecting PRP to a pulsed electrical field in a specially designed instrument developed by sponsor. Two 9 cm2 contralateral regions of interest (ROI) on the scalp will be treated with approximately 6mL of either PRP or PEFA-PRP by subcutaneous injection.
Study: NCT05048368

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Larotinib
Description: Capsules, Oral, 350 mg, single dose, one day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Larotinib
Description: Capsules, Oral, 350 mg, single dose, one day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Larotinib
Description: Capsules, Oral, 350 mg, single dose, one day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Larotinib
Description: Capsules, Oral, 350 mg, single dose, one day
Study: NCT06529549

Intervention type: OTHER
Intervention: Organoid-Based Drug Sensitivity Screening
Description: Residual tissue of bone metastatic sites from biopsies for genetic testing will be collected to culture organoid and perform drug sensitivity screening
Study: NCT06016569

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Vital signs
Description: Blood pressure, weight, height, pulse, oxygen saturation will be measured.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Spirometry
Description: Spirometry will be performed.
Study: NCT06618911

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 5 Hz electroacupuncture
Description: Intervention Description:~The intervention in this study involves the use of electroacupuncture (EA), a combination of traditional acupuncture and electrical stimulation.~Acupoints Selection: Electroacupuncture will be performed at specific acupoints associated with the stomach and digestive system. The local acupoints chosen are Liangmen (ST21) and Tianshu (ST25), while the distal acupoints are Zusanli (ST36) and Xiajuxu (ST39). This selection is based on Traditional Chinese Medicine (TCM) principles for treating functional dyspepsia.~Frequency: 5 Hz

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham electroacupuncture
Description: Participants will receive sham electroacupuncture at the same acupoints: Liangmen (ST21), Tianshu (ST25), Zusanli (ST36), and Xiajuxu (ST39). Non-penetrating needles will touch the skin but will not induce \&#34;deqi.\&#34; A sham electroacupuncture device (no actual current) will be used, and treatment will last 30 minutes per session. Participants will receive 3 sessions per week for 4 weeks (total: 12 sessions). This arm serves as a placebo control to evaluate the true effect of electroacupuncture.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 100 Hz electroacupuncture
Description: Intervention Description:~The intervention in this study involves the use of electroacupuncture (EA), a combination of traditional acupuncture and electrical stimulation.~Acupoints Selection: Electroacupuncture will be performed at specific acupoints associated with the stomach and digestive system. The local acupoints chosen are Liangmen (ST21) and Tianshu (ST25), while the distal acupoints are Zusanli (ST36) and Xiajuxu (ST39). This selection is based on Traditional Chinese Medicine (TCM) principles for treating functional dyspepsia.~Frequency: 100 Hz
Study: NCT06620445

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Interventiion or CBT Group
Description: This RCT aims to evaluate the effect of Cognitive Behavioral Therapy (CBT) compared to usual care (UC) in pediatric oncology patients. We hypothesize that those receiving CBT will report lower depression and anxiety and improved QoL six months post-enrollment.
Study: NCT06620510

Intervention type: BIOLOGICAL
Intervention: Immuncell-LC
Description: Activated T lymphocyte

Intervention type: BIOLOGICAL
Intervention: No Interventions
Description: Patients who were in non-treatment group in phase 3 clinical trial IIC-I01(NCT00699816).
Study: NCT06622122

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness Intervention for Emotional Distress(MIED)-normal version
Description: Mindfulness Intervention for Emotional Distress (MIED) program provides standard audio instructions for mindfulness exercises, introduces the nature and law of anxiety, depression, and other emotions, the source of anxiety, depression, and other emotional distress, and the strategies and methods to alleviate emotional distress. These exercises, knowledge and strategies are based on the latest progress in the field of psychological counseling and treatment, and their application in daily life can help alleviate anxiety, depression and other emotional problems.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness Intervention for Emotional Distress(MIED)-increase cognitive flexibility
Description: Increase the intervention dose of cognitive flexibility in Mindfulness Intervention for Emotional Distress (MIED). For example, including more cognitive reappraisal practice, psychoeducational content and practice about regarding thoughts just as thoughts.
Study: NCT06618027

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: BREATHE-T1D
Description: BREATHE-T1D was adapted from Learning to BREATHE, a group mindfulness-based intervention for teens. It teaches mindfulness strategies adapted to be specific and relatable to, teens with T1D to improves symptoms of depression and anxiety as well as diabetes self-management.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: HealthEd-T1D
Description: HealthEd-T1D is a 6 week, virtual, group based diabetes education group.
Study: NCT06618625

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: nasotracheal intubation
Description: For nasotracheal intubation, the nasal RAE tube will be inserted with it rotated by 90 degrees in counter-clockwise direction for patients in the 'Rotation' arm.~For nasotracheal intubation, the nasal RAE tube will be inserted without tube rotation for patients in the 'Neutral' arm.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: nasotracheal intubation
Description: For nasotracheal intubation, the nasal RAE tube will be inserted with it rotated by 90 degrees in counter-clockwise direction for patients in the 'Rotation' arm.~For nasotracheal intubation, the nasal RAE tube will be inserted without tube rotation for patients in the 'Neutral' arm.
Study: NCT06620835

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood samples for Hematology
Description: Complete blood count will include erythrocytes, neutrophils, eosinophils, basophils, lymphocytes, monocytes, platelets, leukocytes, hemoglobin, hematocrit.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood samples for Chemistry
Description: Clinical chemistry will include serum electrolytes (sodium, potassium, calcium, corrected calcium for hypoalbuminemia), creatinine, CrCl with local formula, and fasting blood glucose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood sample for liver function tests
Description: Laboratory tests to assess liver function will include Aminotransferase Alanine (ALAT), Aminotransferase Aspartate (ASAT), Phosphatase Alkaline (ALP), Gamma-glutamyl Transferase (GGT), total and conjugated bilirubin.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pregnancy test
Description: Pregnancy test will be performed in women of childbearing potential, including women who have had a tubal ligation. Childbearing potential is defined as not having undergone surgical sterilization, hysterectomy, and/or bilateral oophorectomy or not being postmenopausal (≥12 months of amenorrhea). Urine pregnancy tests will be based on the measurement of β-Human Chorionic Gonadotropin (HCG). If a urine pregnancy test is positive, it must be confirmed by a serum pregnancy test. Urine pregnancy tests will be performed at screening.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tumour assessment
Description: Tumor assessment according to the RECIST v1.1 include the following radiological evaluation: thoracic CT scan, brain MRI or CT scan (MRI is preferred), abdominopelvic scan, PET-CT scan mandatory and at the Investigator's discretion, if needed bone scintigraphy and chest X-ray.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Local Ablative Therapy (LAT)
Description: Local Ablative Treatment (LAT) (stereotactic body radiotherapy, surgery, thermal ablation)
Study: NCT06618248

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Sirolimus coated balloon angioplasty
Description: This study involves the use of a Sirolimus-Coated Balloon (SCB) for the treatment of coronary artery disease, specifically targeting coronary bifurcation lesions. The SCB is coated with sirolimus, an antiproliferative drug that helps to prevent restenosis by inhibiting smooth muscle cell proliferation. The balloon is inflated at the target lesion site, delivering the drug directly to the arterial wall. This intervention aims to achieve vessel dilation while reducing the risk of restenosis, providing a potential alternative to stent placement.

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Paclitaxel coated balloon angioplasty
Description: This study involves the use of a Paclitaxel-Coated Balloon (PCB) for the treatment of coronary artery disease, specifically targeting coronary bifurcation lesions. The PCB is coated with paclitaxel, an antiproliferative drug that helps to prevent restenosis by inhibiting smooth muscle cell proliferation. The balloon is inflated at the target lesion site, delivering the drug directly to the arterial wall. This intervention aims to achieve vessel dilation while reducing the risk of restenosis, providing a potential alternative to stent placement.
Study: NCT06620978

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Low pressure: Operative hysteroscopy without anesthesia with normal Saline medium in low pressure..
Description: Low pressure: Operative hysteroscopy without anesthesia with normal Saline medium in low pressure..~Operative hysteroscopy without anesthesia using normal Saline as medium with different pressure according to the arm allocated. The procedure is done for endometrial polyp removal, retained products of conception removal, intrauterine adhesyolisis and intrauterine device removal.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: High pressure: Operative hysteroscopy without anesthesia with normal Saline medium in High pressure.
Description: High pressure: Operative hysteroscopy without anesthesia with normal Saline medium at high pressure.
Study: NCT06620562

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Naltrexone/Bupropion
Description: Patient randomized in the Neltrexone/Bupropion group will be started one month after surgery on a progressive dose of Naltrexone/Bupropion extended-release 8mg/90mg, up to 2 tabs twice a day (32mg/360mg) adjusted according to tolerance and side-effects to improve long-term use. Duration of therapy will be 24 months.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Patient randomized in the placebo group will be started one month after surgery on a progressive numbers of matched placebo tablets up to 2 tabs twice a day. Duration of therapy will be 24 months.
Study: NCT06621797

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Intervention 1: Dietary Supplement - Caffeine Supplement
Description: Participants in this group will receive a caffeine supplement (3 mg/kg body weight) taken orally 45 minutes before performance testing. No additional interventions will be administered.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Intervention 2: Dietary Supplement - Caffeine + L-Theanine Supplement
Description: Participants in this group will receive a caffeine supplement (3 mg/kg body weight) along with L-theanine in a 1:2 ratio taken orally 45 minutes before performance testing.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention 3: Dietary Supplement - Caffeine Supplement + Diaphragmatic Breathing Exercises
Description: Participants in this group will receive a caffeine supplement (3 mg/kg body weight) 45 minutes before performance testing, followed by a 10-minute session of diaphragmatic breathing exercises.
Study: NCT06620900

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Integrated Model of Care
Description: The Integrated Model of Care was developed and piloted by the study team provide support for individuals seeking care in an interdisciplinary intensive outpatient program for mild traumatic brain injury to receive support for co-occurring substance use-related needs.
Study: NCT06619340

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Exparel
Description: 20 milliliter (mL) EXPAREL with 20mL bupivacaine hydrochloride (HCL) 0.5% will be expanded. An 18-gauge bevel needle will be introduced through the capsular pocket at 1 to 2cm proximal to the adductor tubercle at the proximal border of the posteromedial femoral condyle. The needle will be angled proximally and posteriorly, and then advanced to contact the posteromedial capsule. A 20mL bolus of the study drug admixture will be administered. The remaining 20mL of the study drug admixture will be administered to the anterior and lateral knee structures with approximately 1 to 1.5mL administered with each stick to the intended area.
Study: NCT06618261

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Caffeine + Resistance exercise
Description: Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Caffeine + Resistance exercise
Description: Acute caffeine intake (3 mg/kg) prior each resistance training session of a 8 weeks training program.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo + Resistance exercise
Description: Acute placeb intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo + Resistance exercise
Description: Acute placeb intake (3 mg/kg of maltodextrin) prior each resistance training session of a 8 weeks training program.
Study: NCT06623838

Intervention type: DIAGNOSTIC_TEST
Intervention: Evolutionarily informed case conceptualization
Description: Case conceptualization of personality functioning of a few transcripts of initial sessions and report of psychometric measures of patients diagnosed with personality disorder.

Intervention type: DIAGNOSTIC_TEST
Intervention: Evolutionarily informed case conceptualization
Description: Case conceptualization of personality functioning of a few transcripts of initial sessions and report of psychometric measures of patients diagnosed with personality disorder.

Intervention type: DIAGNOSTIC_TEST
Intervention: Evolutionarily informed case conceptualization
Description: Case conceptualization of personality functioning of a few transcripts of initial sessions and report of psychometric measures of patients diagnosed with personality disorder.

Intervention type: DIAGNOSTIC_TEST
Intervention: Evolutionarily informed case conceptualization
Description: Case conceptualization of personality functioning of a few transcripts of initial sessions and report of psychometric measures of patients diagnosed with personality disorder.

Intervention type: DIAGNOSTIC_TEST
Intervention: Evolutionarily informed case conceptualization
Description: Case conceptualization of personality functioning of a few transcripts of initial sessions and report of psychometric measures of patients diagnosed with personality disorder.