TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05298215

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: UB-221
Description: UB-221 is a recombinant humanized IgG1 monoclonal antibody with neutralizing capability against soluble human IgE and CD23-bound IgE for the treatment of allergic diseases. The activity of UB-221 is directly through the high-affinity binding with soluble and membrane bound IgE. The neutralization of soluble IgE will desensitize the activation of mast cells and basophils by inhibiting IgE cross-linking and down-regulation of FcεRI (high affinity IgE receptor) expression on those cells. The binding to CD23-bound IgE may inhibit IgE synthesis by stabilization of membrane-bound CD23 on B lymphocytes.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: UB-221
Description: UB-221 is a recombinant humanized IgG1 monoclonal antibody with neutralizing capability against soluble human IgE and CD23-bound IgE for the treatment of allergic diseases. The activity of UB-221 is directly through the high-affinity binding with soluble and membrane bound IgE. The neutralization of soluble IgE will desensitize the activation of mast cells and basophils by inhibiting IgE cross-linking and down-regulation of FcεRI (high affinity IgE receptor) expression on those cells. The binding to CD23-bound IgE may inhibit IgE synthesis by stabilization of membrane-bound CD23 on B lymphocytes.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: sterile saline solution
Description: sterile saline solution (0.9% NaCl) for intravenous (IV) infusion
Study: NCT05405478

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Omalizumab
Description: subcutaneous injection every 2 or 4 weeks, depending on the pretreatment serum total IgE level and body weight

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: SNOT22 score
Description: score will measure at screening; on day 1; and at weeks 4, 8, 16, and 24 (point range, 0-110)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: SNOT22 score
Description: score will measure at screening; on day 1; and at weeks 4, 8, 16, and 24 (point range, 0-110)
Study: NCT06572527

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Physical Activity Program
Description: Nurse-Led Coordinated Physical Activity Program for Child Health, developed as part of the Coordinated Approach to Child Health program for preschool children.
Study: NCT06573424

Intervention type: COMBINATION_PRODUCT
Intervention: Tislelizumab+anlotinib
Description: Patients who have been treated with anlotinib + tislelizumabline

Intervention type: DRUG
Intervention: anlotinib
Description: Patients who have been treated with anlotinib monotherapy
Study: NCT05383677

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Anifrolumab
Description: Anifrolumab 300 mg will be administered in intravenous infusions once per 4 weeks, for a total treatment period of 24 weeks.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will be administered in intravenous infusions once per 4 weeks, for a total treatment period of 24 weeks.
Study: NCT05852444

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Passive Ultrasonic Activation
Description: Agitation of root canal irrigation solution with an ultrasonic activation device (Ultra X).

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Manual Dynamic Agitation
Description: Agitation of root canal irrigation solution with master gutta percha cone
Study: NCT05580575

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Daily disposable toric soft contact lens
Description: Daily disposable toric soft contact lens

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Daily disposable toric soft contact lens
Description: Daily disposable toric soft contact lens

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Monthly replacement toric daily wear soft contact lens
Description: Monthly replacement toric daily wear soft contact lens

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Monthly replacement toric daily wear soft contact lens
Description: Monthly replacement toric daily wear soft contact lens
Study: NCT06533839

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Permanent colostomy
Description: A long-term (permanent) colostomy will be performed in the diseased colon or rectum.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Permanent colostomy
Description: A long-term (permanent) colostomy will be performed in the diseased colon or rectum.
Study: NCT04798586

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Elranatamab (PF-06863135)
Description: BCMA-CD3 bispecific antibody
Study: NCT06500078

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intermittent dietary restriction
Description: Intermittent dietary restriction will include the ILCD and ICR, which will be self-administered interventions in daily lives. The ILCD intervention will ask participants to restrict carbohydrate intake to ≤ 50 g/d on two consecutive or discontinuous days per week. The ICR intervention will ask participants to restrict caloric intake to 600 kcal/d for boys and 500 kcal/d for girls on two consecutive or discontinuous days per week.~At baseline, participants will receive face-to-face oral dietary instructions (e.g., principle of dietary restriction, sample menus, food list with macronutrients). Participants will receive the intervention booklets containing dietary advice and sample menus for diet according to the requirements of the dietary intervention.~Participants will be required to record dietary and physical activity data on a regular basis. The total intervention duration will be 12 months, including a 3-month intervention phase and a 9-month self-maintenance phase.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: General health education
Description: General health education based on dietary and physical activity guidelines for Chinese children and adolescents, will regularly send offline and online promotional materials to participants.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: General health education
Description: General health education based on dietary and physical activity guidelines for Chinese children and adolescents, will regularly send offline and online promotional materials to participants.
Study: NCT04819360

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: VESIcare 10Mg Tablet
Description: Vesicare® 10 mg per day for 12 weeks~Vesicare 10mg 12 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Botox 100 UNT Injection
Description: 1 injection of Botox® 100 UNT
Study: NCT05772065

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CDC/NTCA guidelines only
Description: The control group will have a link to US guidelines only.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: LTBI ASSIST and CDC/NTCA guidelines only
Description: The intervention group will have a link to both US guidelines, and the LTBI-ASSIST tool.
Study: NCT06105307

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: RN-SLEEP
Description: RN-SLEEP is a training program delivered via mobile application and designed to help improve the sleep of nurses who engage in shift work. RN-SLEEP aims to include training on strategies for sleeping while working shift work, basics of sleep science and physiology, behavior change components (i.e., goal setting), and components of cognitive behavioral therapy for insomnia (i.e., relaxation).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Healthy Habit - Educational Control
Description: Healthy habit app (i.e., exercise tracking) to act as a control arm for the RN-SLEEP intervention
Study: NCT06250738

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-based Stress reduction program: Virtual
Description: Through mindfulness meditation and a series of carefully crafted exercises, MBSR equips individuals with powerful tools to manage stress, reduce anxiety, and enhance their overall well-being. Participants will complete 4 weekly virtual sessions covering topics like introduction to stress and its consequences, awareness of sensations, and thoughts, mindful eating, and mindful walking.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Home exercises
Description: Following each virtual session, participants will be given home exercises like practicing awareness of breathing, awareness of thoughts, and awareness of eating.
Study: NCT06123767

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: CAS + Intravascular measuring the pressure gradient
Description: Measurements taken during the procedure during CAS~* placement of a FFR- micro catheter on the neuroprotection wire and taking a measurement before the stenosis and in the internal carotid artery above the stenosis~* reading the pressure gradient after obtaining a stable value (a minimum of 5 cardiac cycles)~  * the study of intravascular pressure measurements will be performed using a special micro catheter

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: CAS (standard)
Description: Animation of blood pressure measurements on the FFR console without actual measurement in carotid artery (blinding of the study to the patient) during CAS procedure.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: CAS (standard)
Description: Animation of blood pressure measurements on the FFR console without actual measurement in carotid artery (blinding of the study to the patient) during CAS procedure.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Doppler ultrasonound of cephalic arteries
Description: non-invasive assessment of carotid stenosis before surgery and assessment of results after CAS (3 and 12 months after CAS)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Doppler ultrasonound of cephalic arteries
Description: non-invasive assessment of carotid stenosis before surgery and assessment of results after CAS (3 and 12 months after CAS)

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Angio-CT of the neck and head
Description: Non-invasive pre-operative assessment and post-CAS result (3 months after)

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Angio-CT of the neck and head
Description: Non-invasive pre-operative assessment and post-CAS result (3 months after)

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Otolaryngological examination
Description: Hearing and balance tests (before and after CAS) - prospective follow-up

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Otolaryngological examination
Description: Hearing and balance tests (before and after CAS) - prospective follow-up

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Psychological examination
Description: psychological examination with questionnaires (before and after CAS) - prospective follow-up

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Psychological examination
Description: psychological examination with questionnaires (before and after CAS) - prospective follow-up

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Neurological examination
Description: neurological examination with questionnaires (before and after CAS) - prospective follow-up
Study: NCT06090500

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cryotherapy
Description: preoperative submucosal infiltration injection of cold saline solution (2-5 degrees Celsius)

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Diclofenac sodium
Description: preoperative submucosal infiltration injection of Diclofenac sodium (25mg/ml)

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone sodium phosphate
Description: preoperative submucosal infiltration injection of dexamethasone sodium phosphate (4mg/ml)
Study: NCT06123767

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Neurological examination
Description: neurological examination with questionnaires (before and after CAS) - prospective follow-up
Study: NCT06426992

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Microwave ablation
Description: Following the existing procedure of our institute, we aim to treat the tumor by applying up to 150W of microwaves within the tumor using a StarWave microwave generator and a 13-gauge antenna under fusion ultrasound guidance. If necessary, the antenna is reinserted 1-2 times to create sufficient ablation lesions until an echogenic band of 5-10mm is formed around the tumor and its periphery, implementing overlapping microwave ablation (MWA). Afterward, the antenna is removed while applying microwave energy to prevent bleeding.
Study: NCT06123767

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: MR cerebral perfusion
Description: Assessment of the cerebral perfusion alterations using DSC (dynamic susceptibility contrast) MR perfusion, before and after CAS (after 3 months):~Parametric maps of cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT) will be generated and used for the qualitative and quantitative analyses of the following perfusion parameters:~* cerebral blood volume (CBV) value in ml/100ml;~* cerebral blood flow (CBF) value in ml/100ml/min;~* mean transit time (MTT) value in seconds~* time to peak (TTP) value in seconds

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: MR cerebral perfusion
Description: Assessment of the cerebral perfusion alterations using DSC (dynamic susceptibility contrast) MR perfusion, before and after CAS (after 3 months):~Parametric maps of cerebral blood flow (CBF), cerebral blood volume (CBV), time to peak (TTP), and mean transit time (MTT) will be generated and used for the qualitative and quantitative analyses of the following perfusion parameters:~* cerebral blood volume (CBV) value in ml/100ml;~* cerebral blood flow (CBF) value in ml/100ml/min;~* mean transit time (MTT) value in seconds~* time to peak (TTP) value in seconds
Study: NCT06119659

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Low dose KL001
Description: Subjects will be dosed with single dose of KL001 at 2.5x10\^12 vg/kg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Middle dose KL001
Description: Subjects will be dosed with single dose of KL001 at 5.0x10\^12 vg/kg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: High dose KL001
Description: Subjects will be dosed with single dose of KL001 at 1.0x10\^13 vg/kg.
Study: NCT06275893

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IC14
Description: recombinant monoclonal antibody directed against cluster of differentiation 14 (CD14) antigen
Study: NCT06339034

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Lithium
Description: 5mg of elemental lithium/capsule

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Cellulose-filled capsules
Study: NCT06292728

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ENDOPLY System
Description: One endoscopic procedure where the ENDOPLY System is used for endoscopic gastric plication.
Study: NCT06157502

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Shuxuening Injection
Description: Receiving 20 ml Shuxuening injection plus 250ml 0.9% sodium chloride injection, intravenous drip once a day, for 10-14 days

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Receiving 20 ml placebo Shuxuening injection plus 250ml 0.9% sodium chloride injection, intravenous drip once a day, for 10-14 days.
Study: NCT05712226

Intervention type: DEVICE
Group type: OTHER
Intervention: Sleepiz One+
Description: In this study Sleepiz One+ will measure heart rate and respiration rate of a participant sitting or lying in different positions (right and left side, back, abdomen) on a bed. The recording will take around 35 minutes.
Study: NCT06194903

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: isopropyl alcohol wipes
Description: cellphones will be sanitised with isopropyl alcohol wipes and total bacterial load will be assessed immediately before sanitation, immediately after sanitation and 3 hours after sanitation.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: UVC box
Description: cellphones will be sanitised in a UVC box and total bacterial load will be assessed immediately before sanitation, immediately after sanitation and 3 hours after sanitation.
Study: NCT05464511

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Left atrial appendage occlusion with the dual mechanism closure Amulet device using a novel steerable sheath.
Description: Left atrial appendage occlusion with the dual mechanism closure Amulet device using a novel steerable sheath.
Study: NCT05966831

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Metacognitive Self-Control Training (MCT)
Description: Metacognitive Self-Control Training (MCT) was originally developed by the Michigan Skills Project for students in middle/high school. The MCT training intervention has been updated to be suitable for adults. MCT is a lecture style intervention that encompasses 13 modules (over the course of 4 weeks) on improving self-control that is to be delivered in a community setting. Across the training, participants will learn new tools for improving self-control.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Virtual Reality Job Interview Training (VR-JIT)
Description: VR-JIT provides trainees with an opportunity to repeatedly practice interviewing for a job at fictional company 'Wondersmart'. Prior to interviewing, trainees review self-guided e-learning materials on how to find, prepare for, succeed in, and follow-up on job interviews that includes the review of 10 job interview skills. Trainees also complete an online job application for one of 14 jobs (e.g., cashier, clerical, customer service, food services, inventory, janitorial, web developer) that informs the virtual interview experience.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Virtual Reality Job Interview Training (VR-JIT)
Description: VR-JIT provides trainees with an opportunity to repeatedly practice interviewing for a job at fictional company 'Wondersmart'. Prior to interviewing, trainees review self-guided e-learning materials on how to find, prepare for, succeed in, and follow-up on job interviews that includes the review of 10 job interview skills. Trainees also complete an online job application for one of 14 jobs (e.g., cashier, clerical, customer service, food services, inventory, janitorial, web developer) that informs the virtual interview experience.
Study: NCT06047197

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: RC19D2 cell injection
Description: The functional component of RC19D2 cell injection is T cells that have been genetically modified to express anti CD19 chimeric antigen receptors.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: RC19D2 cell injection
Description: The functional component of RC19D2 cell injection is T cells that have been genetically modified to express anti CD19 chimeric antigen receptors.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: RC19D2 cell injection
Description: The functional component of RC19D2 cell injection is T cells that have been genetically modified to express anti CD19 chimeric antigen receptors.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: RC19D2 cell injection
Description: The functional component of RC19D2 cell injection is T cells that have been genetically modified to express anti CD19 chimeric antigen receptors.
Study: NCT05874258

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Real-PL training + Real-tES(tDCS)
Description: PLtraining : around 40mins, tDCS: 20mins

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Real-PL training + Sham-tES (tDCS)
Description: PL training : around 40mins, tDCS: 20mins

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo-PL training + Sham-tES (tDCS)
Description: PL training : around 40mins, tDCS: 20mins
Study: NCT04900974

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doravirine
Description: 100mg
Study: NCT06394128

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cangpo Liujun Prescription
Description: Based on the diagnostic criteria of spleen deficiency and dampness excess syndrome, Cangpo Liujun Prescription could be used to treat cancer-related fatigue in patients with advanced colorectal cancer undergoing second-line chemotherapy.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Cangpo Liujun Prescription
Description: Based on the diagnostic criteria of spleen deficiency and dampness excess syndrome, Cangpo Liujun Prescription could be used to treat cancer-related fatigue in patients with advanced colorectal cancer undergoing second-line chemotherapy.
Study: NCT05771519

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: HIV disclosure intervention
Description: This will be a biobehavioral intervention focused on helping men with HIV to disclose their HIV status to a personal confidant inclusive with specific focus on sexual partners.
Study: NCT06052384

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard pain management combined with sleep disorder management
Description: Standard pain management combined with sleep disorder management at M3, M6, and M12
Study: NCT05067075

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Blinded CGM
Description: CGM that records blood glucose but is not visible to patient or provider in real-time
Study: NCT05501509

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Coracoclavicular fixation with acromioclavicular stabilization for the management of an unstable acromiclavicular luxation
Description: Using a 3-hole third plate and high resistance sutures across the acromioclavicular joint to achieve horizontal and vertical stability of the joint
Study: NCT05327790

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lyophilized fecal microbiota (LFMT)
Description: vedolizumab or ustekinumab + FMT vs placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lyophilized fecal microbiota (LFMT)
Description: vedolizumab or ustekinumab + FMT vs placebo

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06427954

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Digital Health App
Description: access to a digital health app
Study: NCT05501509

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Coracoclavicular fixation for the management of an unstable acromiclavicular luxation
Description: Isolated coracoclavicular repair using a 3 hole third plate.
Study: NCT06154772

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Color Therapy
Description: Color therapy will be applied to the body chakras for 10-15 minutes with colored fabrics, color therapy with water and colored light lamp.
Study: NCT06534333

Intervention type: OTHER
Intervention: Ultrasonography
Description: musculoskeletal ultrasonography

Intervention type: OTHER
Intervention: Ultrasonography
Description: musculoskeletal ultrasonography