Study: NCT06795100

Intervention type: OTHER
Group type: OTHER
Intervention: Pre-inclusion
Description: Information and presentation of the proposed study to participants during the anesthesia consultation scheduled prior to surgery, including provision of the information document and consent form. Trial participants will have at least 2 days to decide whether or not to take part in the trial.

Intervention type: OTHER
Group type: OTHER
Intervention: Pre-inclusion
Description: Information and presentation of the proposed study to participants during the anesthesia consultation scheduled prior to surgery, including provision of the information document and consent form. Trial participants will have at least 2 days to decide whether or not to take part in the trial.

Intervention type: OTHER
Group type: OTHER
Intervention: Inclusion
Description: Participants will be welcomed according to the usual process in the digestive, hepatic, urological, or gynecological surgery service. The inclusion visit will coincide with the pre-anesthesia visit during which the absence of contraindications for starting the study will be verified, particularly the occurrence of any health changes since the anesthesia visit that would contraindicate anesthesia or lidocaine administration. During this visit, participant consent will be obtained. The informed consent form must be signed no later than the morning of the intervention.~For women of childbearing age, the absence of current pregnancy will be verified orally for each participant included. A pregnancy test may be performed if the participant so wishes, but a systematic test is not justified.

Intervention type: OTHER
Group type: OTHER
Intervention: Inclusion
Description: Participants will be welcomed according to the usual process in the digestive, hepatic, urological, or gynecological surgery service. The inclusion visit will coincide with the pre-anesthesia visit during which the absence of contraindications for starting the study will be verified, particularly the occurrence of any health changes since the anesthesia visit that would contraindicate anesthesia or lidocaine administration. During this visit, participant consent will be obtained. The informed consent form must be signed no later than the morning of the intervention.~For women of childbearing age, the absence of current pregnancy will be verified orally for each participant included. A pregnancy test may be performed if the participant so wishes, but a systematic test is not justified.

Intervention type: DRUG
Group type: OTHER
Intervention: Lidocaine
Description: Induction of anesthesia will be at the discretion of the attending anesthesiologist, with a lidocaine bolus of 2 mg/kg administered over 1 minute, followed by a continuous IV infusion of 2 mg/kg/h.

Intervention type: DRUG
Group type: OTHER
Intervention: Lidocaine
Description: Induction of anesthesia will be at the discretion of the attending anesthesiologist, with a lidocaine bolus of 2 mg/kg administered over 1 minute, followed by a continuous IV infusion of 2 mg/kg/h.

Intervention type: OTHER
Group type: OTHER
Intervention: Pharmacokinetic study of intravenous lidocaine
Description: Blood samples of 3 mL will be collected in heparinized tubes without gel of 4 ml at 30, 60 and 120 minutes after the start of lidocaine infusion, then every two hours during surgery, and two finals samples at 15 and 60 minutes after the infusion stops.

Intervention type: OTHER
Group type: OTHER
Intervention: Pharmacokinetic study of intravenous lidocaine
Description: Blood samples of 3 mL will be collected in heparinized tubes without gel of 4 ml at 30, 60 and 120 minutes after the start of lidocaine infusion, then every two hours during surgery, and two finals samples at 15 and 60 minutes after the infusion stops.

Intervention type: OTHER
Group type: OTHER
Intervention: Pain
Description: . Maximal pain reported in the post-anesthesia care unit (PACU) and maximal pain at rest and with movement at 24 hours post-extubation will be recorded.

Intervention type: OTHER
Group type: OTHER
Intervention: Pain
Description: . Maximal pain reported in the post-anesthesia care unit (PACU) and maximal pain at rest and with movement at 24 hours post-extubation will be recorded.

Intervention type: OTHER
Group type: OTHER
Intervention: adverse effects/events
Description: Any adverse effects/events will be documented from the start of lidocaine administration until 24 hours post-extubation,

Intervention type: OTHER
Group type: OTHER
Intervention: adverse effects/events
Description: Any adverse effects/events will be documented from the start of lidocaine administration until 24 hours post-extubation,

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: biological blood test
Description: A biological blood test, not performed in routine practice, will be carried out to measure the following parameters: albumin, ASAT, ALAT, PAL, GammaGT, total and conjugated bilirubin, creatinine, with calculation of GFR.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: biological blood test
Description: A biological blood test, not performed in routine practice, will be carried out to measure the following parameters: albumin, ASAT, ALAT, PAL, GammaGT, total and conjugated bilirubin, creatinine, with calculation of GFR.