Study: NCT04489134

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treatment B
Description: Administration of a 2 mg dose of LCP-tacro (Envarsus®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treament C
Description: Administration of a single 120 mg dose of immediate-release verapamil (Isoptine®) and a 3 mg dose of prolonged-release tacrolimus (Advagraf®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treament C
Description: Administration of a single 120 mg dose of immediate-release verapamil (Isoptine®) and a 3 mg dose of prolonged-release tacrolimus (Advagraf®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treament C
Description: Administration of a single 120 mg dose of immediate-release verapamil (Isoptine®) and a 3 mg dose of prolonged-release tacrolimus (Advagraf®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treament C
Description: Administration of a single 120 mg dose of immediate-release verapamil (Isoptine®) and a 3 mg dose of prolonged-release tacrolimus (Advagraf®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treatment D
Description: Administration of a single 120 mg dose of immediate release verapamil (Isoptine®) and a 2 mg dose of LCP-tacro (Envarsus®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treatment D
Description: Administration of a single 120 mg dose of immediate release verapamil (Isoptine®) and a 2 mg dose of LCP-tacro (Envarsus®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treatment D
Description: Administration of a single 120 mg dose of immediate release verapamil (Isoptine®) and a 2 mg dose of LCP-tacro (Envarsus®)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treatment D
Description: Administration of a single 120 mg dose of immediate release verapamil (Isoptine®) and a 2 mg dose of LCP-tacro (Envarsus®)

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pharmacocinetik
Description: Nine sampling points of 7 ml each will be taken on the first day at the CIC UIC and the last sampling point will be carried out at 24 hours from the administration the following morning.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pharmacocinetik
Description: Nine sampling points of 7 ml each will be taken on the first day at the CIC UIC and the last sampling point will be carried out at 24 hours from the administration the following morning.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pharmacocinetik
Description: Nine sampling points of 7 ml each will be taken on the first day at the CIC UIC and the last sampling point will be carried out at 24 hours from the administration the following morning.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pharmacocinetik
Description: Nine sampling points of 7 ml each will be taken on the first day at the CIC UIC and the last sampling point will be carried out at 24 hours from the administration the following morning.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Genetic
Description: A genetic analysis to determine your characteristics for enzymes in your metabolism as well as transport proteins will be carried out. An additional 7 ml blood tube will be drawn for this purpose during the first period.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Genetic
Description: A genetic analysis to determine your characteristics for enzymes in your metabolism as well as transport proteins will be carried out. An additional 7 ml blood tube will be drawn for this purpose during the first period.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Genetic
Description: A genetic analysis to determine your characteristics for enzymes in your metabolism as well as transport proteins will be carried out. An additional 7 ml blood tube will be drawn for this purpose during the first period.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Genetic
Description: A genetic analysis to determine your characteristics for enzymes in your metabolism as well as transport proteins will be carried out. An additional 7 ml blood tube will be drawn for this purpose during the first period.