TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04748133

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: acupuncture needles
Description: Site of acupuncture points:~* Du 26: At junction of the upper and middle third of philtrum.~* Ren 17: On the midline level with the 4th intercostal space midway between the nipples.~* LI4 (Large Intestine 4): On the dorsum of the hand, between the 1st and 2nd metacarpal bones~* HT7 (Heart 7): On the ulnar end of the transverse crease of the wrist, in the small depression between the pisiform and ulna bones~* LV3 (Liver 3): On dorsum of the foot in a depression distal to the junction of the 1st and 2nd metatarsal bones.~* ST36 (Stomach 36): Antero-lateral leg, 1 middle-finger breadth next to the anterior crest of tibia, 3 cun under the depression lateral to the patellar ligament.~* PC6 (Pericardium 6): Palmar aspect of the forearm, between the tendons, 2 cun away from the transverse crease of the wrist
Study: NCT05374070

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Streptococcus salivarius K12 Powder 1 Billion colony forming units /g)
Description: Probiotic Streptococcus salivarius K12 products are commercially available in traditional formats such as lozenges for local delivery in the oral cavity to provide oral health benefits. In this study, a powder formulation will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Streptococcus salivarius K12 Powder (1 Billion colony forming units /g) with a prebiotic included
Description: In this study, a powder formulation containing Streptococcus salivarius K12 and a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius K12 to the oral cavity.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Streptococcus salivarius M18 Powder (1 Billion colony forming units /g)
Description: In this study, a powder formulation will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Streptococcus salivarius M18 Powder (1 Billion colony forming units /g) with a prebiotic included
Description: In this study, a powder formulation containing S. salivarius M18 and a prebiotic will be evaluated for its potential of delivering probiotic Streptococcus salivarius M18 to the oral cavity.
Study: NCT04860674

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PD-1 inhibitor +ICE
Description: PD-1 inhibitor (tirelizumab) combined with ifosfamide, carboplatin and etoposide (ICE) regimen
Study: NCT04748133

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: no treatment
Study: NCT04797962

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Case management
Description: dedicated case management to address social support needs
Study: NCT04841369

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine（CRM197,TT）
Description: 0.5mL,Intramuscular

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine（CRM197,TT）
Description: 0.5mL,Intramuscular

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine（CRM197,TT）
Description: 0.5mL,Intramuscular

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine（CRM197,TT）
Description: 0.5mL,Intramuscular
Study: NCT04817618

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo to iptacopan 200mg b.i.d. (Adults 200mg b.i.d; Adolescents 2x 100mg b.i.d)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: iptacopan
Description: iptacopan 200 mg b.i.d. (Adults 200mg b.i.d; Adolescents 2x 100mg b.i.d)
Study: NCT04841369

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine（CRM197,TT）
Description: 0.5mL,Intramuscular

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine
Description: 0.5mL,Intramuscular

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine
Description: 0.5mL,Intramuscular

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine
Description: 0.5mL,Intramuscular

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: 13-Valent Pneumococcal Polysaccharide Conjugate Vaccine
Description: 0.5mL,Intramuscular
Study: NCT05521438

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QRX003-2% Lotion
Description: QRX003Topical Lotion containing 2% active drug (serine protease inhibitor)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QRX003-4% Lotion QAM
Description: QRX003Topical Lotion containing 4% active drug (serine protease inhibitor)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vehicle
Description: Vehicle Lotion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QRX003-4% Lotion BID
Description: QRX003Topical Lotion containing 4% active drug (serine protease inhibitor)
Study: NCT03209063

Intervention type: DIAGNOSTIC_TEST
Intervention: polymerase chain reaction
Description: diagnostic test as Polymerase chain reaction for detection of Prothrombin gene and methylenetetrahydrofolate reductase gene polymorphisms

Intervention type: DIAGNOSTIC_TEST
Intervention: polymerase chain reaction
Description: diagnostic test as Polymerase chain reaction for detection of Prothrombin gene and methylenetetrahydrofolate reductase gene polymorphisms
Study: NCT06039423

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: The M-TAPA block
Description: A high frequency (6-12 MHz) US linear probe was placed in the sagittal plane on the 10 th costal margin in the midline. The probe was then angulated deeply to visualize the lower surface of the costal cartilage. Via in plane technique, a 21 gauge Tuohy needle was inserted cranially between the lower fascia of the costal cartilage and upper fascia of the transversus abdominis muscle by moving the needle tip towards the posterior aspect of the 10 th costal cartilage and 20 mL bupivacaine (0.25 %) was injected.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Ketorolac
Description: conventional general anaesthesia receiving multimodal analgesia
Study: NCT05162599

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Diagnostic study, experimental evaluative cross-sectional study
Description: This is a cross-sectional diagnostic study with collection of information from the gold standard (or reference test) and the new device
Study: NCT05670561

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: PCIA formula#100ml analgesic solution was prepared by adding 2.5 mg/kg Esketamine and 8mg ondansetron into normal saline. 30min before TACE treatment, the first dose of 2ml was slowly injected intravenously. No obvious adverse reactions were observed for 10min.The PCIA pump was commenced at the beginning of TACE. Parameter setting of intravenous analgesia pump: the total volume is 100ml; The duration is 2ml / h; The single dose is 2ml each time; The limit quantity is 10ml / h; The locking time was 10min and the analgesia lasted for 48h. The target value of analgesia in this study was NRS (Numerical Rating Scale)\< 4; If NRS ≥ 4, when the effect is still poor after adding drugs by pressing the analgesic pump, the investigators will give the remedial drug(dolantin 50mg im st) according to the patient's condition.
Study: NCT05393986

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CT048 Autologous Injection (CT048)
Description: up to 3 times CT048 Autologous Injection infusion
Study: NCT06284330

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Enhanced cascade testing
Description: Direct mailed at-home genetic testing kit to probands' relatives.
Study: NCT05517694

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Pelvic floor exercises and behavioral therapy
Description: Pelvic floor exercises and behavioral therapy interventions include a 4-step treatment protocol: 1) awareness of the pelvic floor muscles, 2) teaching the specific contraction of the pelvic floor muscles, 3) teaching the timing of the contraction and maintenance of the pelvic floor muscles during the intercourse pre-orgasmic sensation with start-stop behavioral therapy, 4) the strengthening exercises of the pelvic floor muscles. For slow twitch fibers, 15 repetitive exercises including 10 seconds of submaximal contraction followed by 10 seconds of relaxation, and 10 repetitive exercises including 1 second submaximal contraction followed by 1 second relaxation for fast-twitch fibers will be given 2 times a day, 3 days a week, 8 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pelvic floor exercises and behavioral therapy
Description: Pelvic floor exercises and behavioral therapy interventions include a 4-step treatment protocol: 1) awareness of the pelvic floor muscles, 2) teaching the specific contraction of the pelvic floor muscles, 3) teaching the timing of the contraction and maintenance of the pelvic floor muscles during the intercourse pre-orgasmic sensation with start-stop behavioral therapy, 4) the strengthening exercises of the pelvic floor muscles. For slow twitch fibers, 15 repetitive exercises including 10 seconds of submaximal contraction followed by 10 seconds of relaxation, and 10 repetitive exercises including 1 second submaximal contraction followed by 1 second relaxation for fast-twitch fibers will be given 2 times a day, 3 days a week, 8 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Respiratory exercises
Description: Pelvic floor exercises and behavioral therapy interventions include a 4-step treatment protocol: 1) awareness of the pelvic floor muscles, 2) teaching the specific contraction of the pelvic floor muscles, 3) teaching the timing of the contraction and maintenance of the pelvic floor muscles during the intercourse pre-orgasmic sensation with start-stop behavioral therapy, 4) the strengthening exercises of the pelvic floor muscles. For slow twitch fibers, 15 repetitive exercises including 10 seconds of submaximal contraction followed by 10 seconds of relaxation, and 10 repetitive exercises including 1 second submaximal contraction followed by 1 second relaxation for fast-twitch fibers will be given 2 times a day, 3 days a week, 8 weeks.~Respiratory exercises will be given 6 breaths/minute with expiration and inspiration times of 7 seconds and 3 seconds, respectively. At least 10 diaphragmatic breaths will be given in each session, 2 times a day, 7 days a week, 8 weeks.
Study: NCT05450627

Intervention type: DRUG
Intervention: Pancreatic Enzyme
Description: Registry of pancreatic enzyme therapy prescribed to included patients
Study: NCT05345028

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: lecithin-based delivery form of Boswellia serrata
Description: 250 mg for 5 days

Intervention type: COMBINATION_PRODUCT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 250 mg for 5 days
Study: NCT05948046

Intervention type: BEHAVIORAL
Intervention: Visual training in hospital
Description: Completion of 1 session of standardized visual training
Study: NCT04683120

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Zenith FLIM Diagnostics
Description: In-vitro
Study: NCT06377709

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: ProACTive™
Description: ProACTive™ intervention, a talking therapy utilising acceptance and commitment therapy (ACT) techniques.
Study: NCT05859243

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Traditional concurrent training
Description: The subjects will perform two sessions per week of traditional concurrent training, consisting of strength training followed by aerobic exercise over 12 weeks, with progressive intensities and training volumes. Each traditional concurrent training session will consist of specific warm-up performed on equipment for upper and lower limbs with a load of less than 30% of the training load. Then the bench press, low row, leg press, extension and knee flexion exercises will be performed. Participants will be instructed to perform the concentric phase of the movement in one second and the eccentric phase in two seconds. After strength training, aerobic training (walking outdoors or on a treadmill) will be performed with intensity based on the adapted BORG effort perception scale (ranged to 0 = minimum effort, to 10 = maximal effort).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Concurrent training consisting of strength training combined with dance classes
Description: Each concurrent training session associated with dance classes will consist of the same strength training as the traditional concurrent training group, but the traditional aerobic training will be replaced by a dance class. Each dance class will consist of a 5-minute general warm-up with joint mobility exercises and dynamic stretching. Then the main part will be performed with the elaboration of choreography, lasting approximately 20 minutes. Finally, there will be a 5-minute cool-down with stretching exercises. Classes will be held in four different dance modalities, divided into four modules.
Study: NCT06102109

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pars plana vitrectomy
Description: 25gauge pars plana vitrectomy: to remove the vitreous if present

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pars plana vitrectomy
Description: 25gauge pars plana vitrectomy: to remove the vitreous if present

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: IOL explantation
Description: Removing if present a subluxated IOL from the anterior chamber or the vitreous cavity

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: IOL explantation
Description: Removing if present a subluxated IOL from the anterior chamber or the vitreous cavity

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Scleral IOL fixation Yamane Technique
Description: Scleral IOL fixation using the Yamane technique. A 3 piece IOL (Kowa Avansee Preset) gets fixated in the sclera using only its haptics, which are externalised 2.5mm behind the blue line. The haptic ends are flanged using a thermo cautery to prevent slipping back in.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Scleral IOL fixation 4-flanged Technique
Description: Scleral IOL fixation using the 4 flanged technique. A 4 loop haptic IOL (Physical Micropure 123) gets fixated in the sclera using one 6.0 polypropylene suture per 2 haptic loops, which are put trough the loops in a W shape. The suture ends are externalised 2.5mm behind the blue line and its ends are flanged using a thermo cautery to prevent slipping back in.
Study: NCT05602077

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: POCUS
Description: POCUS: The ultrasound examination of the injured elbow includes seven standard settings. The probe is placed on the joint in four ventral and in three posterior positions. If hemarthrosis is detected, this is always suspicious of a possible intra-articular fracture. Even the smallest amounts of blood can be detected sonographically. The surfaces of the bones involved in the joint (humerus, ulna, radius) are accurately displayed in all seven sonography settings. Disrupted bone surface indicates a fracture.~XR: The conventional radiograph of the injured elbow consists of three standard views: ap, lateral and Norman oblique.~CBCT: The injured elbow is placed in an almost most extended position in the CBCT tube.
Study: NCT04805710

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: clopidogrel combined with rivaroxaban arm
Description: Patients who have been selected will be randomized to the clopidogrel combined with rivaroxaban arm. clopidogrel 75 mg once daily and rivaroxaban 10 mg once daily
Study: NCT06100874

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sacituzumab Govitecan
Description: Trop-2-directed antibody-drug conjugate, 180 mg single-dose glass vial, via intravenous infusion per protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab
Description: Humanized IgG1 kappa monoclonal antibody, 150mg single-dose vial, via intravenous infusion per protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab and Hyaluronidase-oysk
Description: Recombinant monoclonal antibody, 6 mL vial, via subcutaneous injection per protocol.
Study: NCT05994833

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: VPT
Description: The VPT will be comprised of weekly virtual visits with the participant for one month. During the visits, the physical therapist will review the exercises that were prescribed, adherence, provide feedback to the participant as they execute the exercises onscreen and make corrections, make any progression or adjustments to the exercises, review running cues they learned from the testing session and answer any questions. The therapist will also review any new activities that are initiated during the previous week (to control for confounders), changes in musculoskeletal pain and participation in running volume.
Study: NCT05836064

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: GastroBot
Description: An artificial intelligence-developed and WhatsApp-based software bot. It will send the instructions to the patient through the WhatsApp application, guided by the software bot with multiple and personalized alternative instructions according to results.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conventional explanation
Description: Patients will receive in writing detailed explanation about bowel preparation with polyethylene glycol
Study: NCT05154838

Intervention type: PROCEDURE
Intervention: Drainage and packing of pilonidal abscess
Description: Patients will be treated as per standard care, their wound drained, cleaned and packed. Microbiology swab samples will be obtained.
Study: NCT05625074

Intervention type: PROCEDURE
Intervention: Conventional surgery for great saphenous vein insufficiency
Description: Arch ligation and stripping of great saphenous vein. Prophilatic anticoagulation - Low molecular weight heparin vs DOACs Antibiotics Non-steoridal anti-inflamatory drugs

Intervention type: PROCEDURE
Intervention: Conventional surgery for great saphenous vein insufficiency
Description: Arch ligation and stripping of great saphenous vein. Prophilatic anticoagulation - Low molecular weight heparin vs DOACs Antibiotics Non-steoridal anti-inflamatory drugs

Intervention type: PROCEDURE
Intervention: Conventional surgery for great saphenous vein insufficiency
Description: Arch ligation and stripping of great saphenous vein. Prophilatic anticoagulation - Low molecular weight heparin vs DOACs Antibiotics Non-steoridal anti-inflamatory drugs
Study: NCT06578273

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: NeuroGlove
Description: The NeuroGlove is a plastic chamber with multiple apertures along its length to allow for puffs of air to be directed to the volar surface of the distal forearm, the palm, and the fingers. The NeuroGlove is intended to provide peripheral sensory stimulation to the hand through pneumatic puffs of air to encourage collateral blood supply and sensorimotor development. A pneumatic pump delivers intermittent puffs of air cycling between one second on and two seconds off. The hand with the palm facing up is placed within the device chamber on a gel pad to provide a comfortable resting surface for the duration of the treatment, which lasts approximately thirty minutes.~The device facilitates the rehabilitation, improvement, or restoration of motion in patients with neurological disorders.
Study: NCT05089669

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Interactive e-book
Description: The nasogastric tube feeding interactive e-book has a lot of elements such as text content, videos, pictures, links, and other interactive content with which the students can interact. The participants can use the interactive e-book to learn nasogastric tube feeding.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: paper textbook
Description: The paper textbook has text content and pictures. The participants can use the paper textbook to learn nasogastric tube feeding.
Study: NCT05146843

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitoquinone
Description: Mitoquinone pill, 20 mg/day

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo pill, 20 mg/day
Study: NCT05456958

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: MRI Biofeedback
Description: We will use state-of-the-art fMRI and neurofeedback of brain signals in order to teach patients with PTSD to self-regulate pathological brain activity that is associated with their symptoms. Indeed, feedback information is crucial for learning, where rt-fMRI-based neurofeedback makes information about brain activity accessible to our consciousness (Ros et al., 2014; Sitaram et al., 2017). It thus provides a reinforcement signal to induce personalized learning mechanisms, allowing individuals to search for appropriate cognitive strategies to voluntarily control brain activity. The feedback signal will come from activity within either the amygdala or PCC.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: MRI Biofeedback
Description: We will use state-of-the-art fMRI and neurofeedback of brain signals in order to teach patients with PTSD to self-regulate pathological brain activity that is associated with their symptoms. Indeed, feedback information is crucial for learning, where rt-fMRI-based neurofeedback makes information about brain activity accessible to our consciousness (Ros et al., 2014; Sitaram et al., 2017). It thus provides a reinforcement signal to induce personalized learning mechanisms, allowing individuals to search for appropriate cognitive strategies to voluntarily control brain activity. The feedback signal will come from activity within either the amygdala or PCC.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sham-MRI Biofeedback
Description: In the sham-control arm (N=20), individuals will receive fake neurofeedback signal, i.e., from a successful participant in one of the experimental arms.
Study: NCT05899296

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: dental syringe ( NumBee)
Description: assess the capability of NumBee to reduce anxiety and pain during injection

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Traditional dental syringe
Description: compare the level of anxiety of the traditional dental syringe and the Number dental syringe
Study: NCT05570409

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mycophenolate Mofetil
Description: Mycophenolate mofetil 1g bid for 6 months

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisolone
Description: initially 1mg/kg in a step-down regime for 6 months
Study: NCT05504811

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitMi AD
Description: Exercise using the motion sensing devices and a tablet computer

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional exercise program
Description: Exercise following printed sheets or booklet