Study: NCT04392622

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-Limonene Gelcaps
Description: Administered orally at 2 to 8 grams daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-Limonene Gelcaps
Description: Administered orally at 2 to 8 grams daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-Limonene Gelcaps
Description: Administered orally at 2 to 8 grams daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-Limonene Gelcaps
Description: Administered orally at 2 to 8 grams daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-Limonene Gelcaps
Description: Administered orally at 2 to 8 grams daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-Limonene Gelcaps
Description: Administered orally at 2 to 8 grams daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: D-Limonene Gelcaps
Description: Administered orally at 2 to 8 grams daily

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity modulated radiotherapy (IMRT)
Description: Standard of Care -All patients will receive standard radiation treatment of 66 to 70 Gy given in 33 to 35 fractions (2 to 2.12 Gy/fractions) over 6.5 to 7 weeks.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity modulated radiotherapy (IMRT)
Description: Standard of Care -All patients will receive standard radiation treatment of 66 to 70 Gy given in 33 to 35 fractions (2 to 2.12 Gy/fractions) over 6.5 to 7 weeks.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity modulated radiotherapy (IMRT)
Description: Standard of Care -All patients will receive standard radiation treatment of 66 to 70 Gy given in 33 to 35 fractions (2 to 2.12 Gy/fractions) over 6.5 to 7 weeks.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity modulated radiotherapy (IMRT)
Description: Standard of Care -All patients will receive standard radiation treatment of 66 to 70 Gy given in 33 to 35 fractions (2 to 2.12 Gy/fractions) over 6.5 to 7 weeks.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity modulated radiotherapy (IMRT)
Description: Standard of Care -All patients will receive standard radiation treatment of 66 to 70 Gy given in 33 to 35 fractions (2 to 2.12 Gy/fractions) over 6.5 to 7 weeks.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity modulated radiotherapy (IMRT)
Description: Standard of Care -All patients will receive standard radiation treatment of 66 to 70 Gy given in 33 to 35 fractions (2 to 2.12 Gy/fractions) over 6.5 to 7 weeks.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity modulated radiotherapy (IMRT)
Description: Standard of Care -All patients will receive standard radiation treatment of 66 to 70 Gy given in 33 to 35 fractions (2 to 2.12 Gy/fractions) over 6.5 to 7 weeks.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Standard of Care -Cisplatin as 100 mg/m2 IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Standard of Care -Cisplatin as 100 mg/m2 IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Standard of Care -Cisplatin as 100 mg/m2 IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Standard of Care -Cisplatin as 100 mg/m2 IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Standard of Care -Cisplatin as 100 mg/m2 IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Standard of Care -Cisplatin as 100 mg/m2 IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Standard of Care -Cisplatin as 100 mg/m2 IV

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Xerostomia questionnaire
Description: Xerostomia questionnaire consists of 4 items on dryness while eating/speaking and 4 on dryness at rest. Patients rate each symptom on an 11 point ordinal Likert scale from 0 to 10, with higher scores indicating greater xerostomia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Xerostomia questionnaire
Description: Xerostomia questionnaire consists of 4 items on dryness while eating/speaking and 4 on dryness at rest. Patients rate each symptom on an 11 point ordinal Likert scale from 0 to 10, with higher scores indicating greater xerostomia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Xerostomia questionnaire
Description: Xerostomia questionnaire consists of 4 items on dryness while eating/speaking and 4 on dryness at rest. Patients rate each symptom on an 11 point ordinal Likert scale from 0 to 10, with higher scores indicating greater xerostomia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Xerostomia questionnaire
Description: Xerostomia questionnaire consists of 4 items on dryness while eating/speaking and 4 on dryness at rest. Patients rate each symptom on an 11 point ordinal Likert scale from 0 to 10, with higher scores indicating greater xerostomia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Xerostomia questionnaire
Description: Xerostomia questionnaire consists of 4 items on dryness while eating/speaking and 4 on dryness at rest. Patients rate each symptom on an 11 point ordinal Likert scale from 0 to 10, with higher scores indicating greater xerostomia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Xerostomia questionnaire
Description: Xerostomia questionnaire consists of 4 items on dryness while eating/speaking and 4 on dryness at rest. Patients rate each symptom on an 11 point ordinal Likert scale from 0 to 10, with higher scores indicating greater xerostomia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Xerostomia questionnaire
Description: Xerostomia questionnaire consists of 4 items on dryness while eating/speaking and 4 on dryness at rest. Patients rate each symptom on an 11 point ordinal Likert scale from 0 to 10, with higher scores indicating greater xerostomia