Study: NCT05170763

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PA9159 nasal spray solution, 10 μg one day treatment
Description: Single dose of PA9159 (5 μg/nasal spray) is delivered intranasally through a metered-dose mechanical spray pump, one spray each in the left and right nostril.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PA9159 nasal spray solution, 20 μg one day treatment
Description: Single dose of PA9159 (5 μg/nasal spray) is delivered intranasally through a metered-dose mechanical spray pump, two sprays each in the left and right nostril.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PA9159 nasal spray solution, 40 μg one day treatment
Description: Single dose of PA9159 (10 μg/nasal spray) is delivered intranasally through a metered-dose mechanical spray pump, two sprays each in the left and right nostril.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PA9159 nasal spray solution, 80 μg one day treatment
Description: Single dose of PA9159 (10 μg/nasal spray) is delivered intranasally through a metered-dose mechanical spray pump, four sprays each in the left and right nostril.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PA9159 nasal spray solution, 20 μg 7-day treatment
Description: Repeated doses of PA9159 (5 μg/nasal spray) or Placebo is delivered intranasally through a metered-dose mechanical spray pump, two sprays each in the left and right nostril.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PA9159 nasal spray solution, 40 μg 7-day treatment
Description: Repeated doses of PA9159 (10 μg/nasal spray) is delivered intranasally through a metered-dose mechanical spray pump, two sprays each in the left and right nostril.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo, the same intranasal spray solution without PA9159 active ingredient
Description: Placebo is delivered intranasally through a metered-dose mechanical spray pump with the same volume as the corresponding PA9159 dose group

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo, the same intranasal spray solution without PA9159 active ingredient
Description: Placebo is delivered intranasally through a metered-dose mechanical spray pump with the same volume as the corresponding PA9159 dose group

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo, the same intranasal spray solution without PA9159 active ingredient
Description: Placebo is delivered intranasally through a metered-dose mechanical spray pump with the same volume as the corresponding PA9159 dose group

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo, the same intranasal spray solution without PA9159 active ingredient
Description: Placebo is delivered intranasally through a metered-dose mechanical spray pump with the same volume as the corresponding PA9159 dose group

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo, the same intranasal spray solution without PA9159 active ingredient
Description: Placebo is delivered intranasally through a metered-dose mechanical spray pump with the same volume as the corresponding PA9159 dose group

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo, the same intranasal spray solution without PA9159 active ingredient
Description: Placebo is delivered intranasally through a metered-dose mechanical spray pump with the same volume as the corresponding PA9159 dose group