TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06644859

Intervention type: DEVICE
Intervention: Daily Activity Patterns Using Wearable Tri-Axial Sensors
Description: This intervention uniquely focuses on the prediction of injurious falls by combining daily life gait (DLG) measures (e.g., gait speed, cadence, variability) with daily life physical activity (DLPA) measures (e.g., activity levels, activity fragmentation). Unlike other studies, this analysis leverages data from a large cohort of older women (n=17,466) enrolled in the Women's Health Study (WHS), where participants wore a tri-axial accelerometer for 1 week. Additionally, the study links accelerometer data to long-term health outcomes, specifically fall-related injuries from Centers for Medicare \&amp; Medicaid Services (CMS) records. This is the first study to explore whether combining DLG and DLPA measures, derived from wearable technology, can predict fall-related injuries in an aging population, applying advanced machine learning techniques to this large, anonymized dataset.
Study: NCT06643585

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab-Deruxtecan
Description: Trastuzumab-Deruxtecan (i.v. 5,4 mg/kg, q3w) + endocrine therapy (if hormonal-receptor-positive) for 16 cycles or until relapse, if earlier

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Physicians Choice (PhC).
Description: Continuous treatment of physician's choice (may include endocrine treatment, CDK4/6-Inhibition, T-DM1, Olaparib, Trastuzumab, Pertuzumab, Capecitabine or Neratinib)
Study: NCT06643988

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MemFlex
Description: MemFlex employs cognitive training exercises in self-led sessions to improve 1) switching between specific and general AMs, 2) access to positive AMs, and 3) vividness of positive AMs.
Study: NCT06684431

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: N-pVAX1
Description: Crimean Congo Hemorrhagic Fever Vaccine
Study: NCT04560439

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Dietary Intervention
Description: Undergo METFIT program
Study: NCT05147662

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Damoctocog alfa pegol (Jivi, BAY94-9027)
Description: Part A: 40 IU/kg (up to 60 IU/kg at the investigator's discretion), two times per week (2x/week) with the first 4 infusions under medical supervision. Thereafter, participants will continue their treatment as home treatment. Dose may be increased up to 60 IU/kg if needed at any time during the study at the investigator's discretion.~Part B: Each participant may continue on prophylaxis dose regimen as prescribed in part A (40 - 60 IU/kg, 2x per week) or adjustments to prophylaxis dose / dose frequency can be made at the investigator's discretion (based on the bleeding events and individual needs): Dose frequency may be decreased to every 5 days with a prophylaxis dose of 60 IU/kg.
Study: NCT06693128

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Camrelizumab
Description: Camrelizumab 200mg
Study: NCT04846101

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: OMNISHADE
Description: Anterior dental cavities (Class III, Class IV) will be restored with an omnishade composite material

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: MULTISHADE
Description: Anterior dental cavities (Class III, Class IV) will be restored with conventional multishade composite material.
Study: NCT05762731

Intervention type: DIAGNOSTIC_TEST
Intervention: Low dose CT thorax
Description: A multi-detector row CT scanner with minimum section collimation of ≤1 mm and minimum number of data acquisition channels ≥ 16will be employed.
Study: NCT04846101

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Instrumental Shade Analysis
Description: Assessment will be performed by single operator using spectrophotometer (EASYSHADE) to detect color difference between tooth and restoration

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Instrumental Shade Analysis
Description: Assessment will be performed by single operator using spectrophotometer (EASYSHADE) to detect color difference between tooth and restoration

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Visual Shade Analysis
Description: Visual assessment will be performed by two calibrated specialists to evaluate shade matching between the tooth and restoration

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Visual Shade Analysis
Description: Visual assessment will be performed by two calibrated specialists to evaluate shade matching between the tooth and restoration

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Patient satisfaction
Description: Patient satisfaction of the final shade match will be assessed on a visual analogue scale
Study: NCT05762731

Intervention type: DIAGNOSTIC_TEST
Intervention: Low dose CT thorax
Description: Control subjects will also proceed to CT thorax, and outcome measures be compared to subjects
Study: NCT05534048

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PTX-COVID19-B
Description: The vaccine product, PTX-COVID19-B, is a preservative-free, sterile mRNA-lipid nanoparticle (mRNA-LNP) dispersion in an aqueous cryoprotectant buffer intended for IM injection.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Comirnaty®
Description: 0.45 mL concentrate in a 2 mL clear multidose vial (type I glass) with a stopper (synthetic Bromo-butyl rubber) and a purple flip-off plastic cap with aluminum seal. Each vial contains 6 doses.
Study: NCT06371352

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: iTBS
Description: Active iTBS over the left DLPFC to induce the long term potentiation of stimulated area.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: cTBS
Description: Active cTBS over the right DLPFC to induce the long term potentiation of stimulated area.
Study: NCT05756738

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Dried blood spot testing
Description: To evaluate the efficacy defined as the rate of diagnostic tests against hepatitis C virus (HCV) performed with a dried blood spot test

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Dried blood spot testing
Description: To evaluate the efficacy defined as the rate of diagnostic tests against hepatitis C virus (HCV) performed with a dried blood spot test
Study: NCT04846101

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Patient satisfaction
Description: Patient satisfaction of the final shade match will be assessed on a visual analogue scale
Study: NCT05826431

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cubii elliptical
Description: Low impact, portable, and compact elliptical for seated use.
Study: NCT06298188

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Risankizumab
Description: Risankizumab
Study: NCT05848440

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD9550
Description: Participants will be administered AZD9550 subcutaneously.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD9550
Description: Participants will be administered AZD9550 subcutaneously.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD9550
Description: Participants will be administered AZD9550 intravenously.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will be administered matching volumes of placebo subcutaneously or intravenously.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will be administered matching volumes of placebo subcutaneously or intravenously.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Participants will be administered matching volumes of placebo subcutaneously or intravenously.
Study: NCT05210049

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Esocheck/Esoguard
Description: All enrolled patients will complete the Esocheck screening test. EsoCheck is a cell collection device that is designed to collect cells of a targeted region of the esophagus. The collected cell material is examined with a two marker panel combining methylated CCNA1 and VIM. These methylated markers have 95% sensitivity and 91% specificity for detecting BE and EAC with an AUC=0.95 in studies performed among white men. Diagnostic yield of this test among Veterans is unknown.
Study: NCT06556784

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: 12-week at-home immersive virtual reality exergame
Description: 12-week training of at least 150 minutes per week at-home immersive virtual reality exergame playing with a set device of Meta Quest 2 and maintaining regular eating and working habits without making significant changes.
Study: NCT04359108

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Navigation System for Users of a Visual Prosthesis
Description: We use common psychophysical judgments such as the following: discriminating between two alternatives by saying which is present in the field of view, touching a tablet computer to indicate the apparent location of a target in the frontal plane, and looking for targets by rotating the head and pointing when one is found. We will compare user performance using the Basic system with user performance using the Augmented and Augmented + Modal systems where contextual information associated with the task is conveyed to users via enhanced visual, auditory, and haptic modalities.
Study: NCT05542199

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Multicomponent nutrition supplement (MCNS)
Description: Palatable daily nutrition supplement for 12 months containing approximately 300 kcal and a wide range of nutrients and plant constituents with potential to support brain health and cognition.
Study: NCT05061524

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: YH35324
Description: Subcutaneous injection of YH35324

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subcutaneous injection of None of active ingredient

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Omalizumab
Description: Subcutaneous injection of Omalizumab
Study: NCT05903482

Intervention type: OTHER
Intervention: None - observational
Description: Observational

Intervention type: OTHER
Intervention: None - observational
Description: Observational
Study: NCT06371352

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham
Description: Sham iTBS or cTBS over the left or right DLPFC respectively for placebo.
Study: NCT05903482

Intervention type: OTHER
Intervention: None - observational
Description: Observational
Study: NCT04631549

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR3680
Description: SHR3680, PO, single dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR3680
Description: SHR3680, PO, single dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR3680
Description: SHR3680, PO, single dose
Study: NCT04692714

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Knee prosthesis implementation with additional cement
Description: During surgery, a TRIATHLON prosthesis will be implemented with the MAKO robot with additional cement.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Knee prosthesis implementation without additional cement
Description: During surgery, a TRIATHLON prosthesis will be implemented with the MAKO robot without additional cement.
Study: NCT06693128

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Camrelizumab
Description: Camrelizumab 200mg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apatinib
Description: Apatinib 250mg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: S-1, Oxaliplatin
Description: S-1, Oxaliplatin, q3w

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: S-1, Oxaliplatin
Description: S-1, Oxaliplatin, q3w
Study: NCT06692309

Intervention type: PROCEDURE
Intervention: cardiovascular surgery
Description: Heart bypass surgery; Heart valve replacement surgery

Intervention type: PROCEDURE
Intervention: cardiovascular surgery
Description: Heart bypass surgery; Heart valve replacement surgery
Study: NCT06693271

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: intervention of protein, blueberries
Description: intervention of 30g/day (1 scoop) of a colorless, tasteless whey protein isolate powder supplement and 1 cup (150 grams) of blueberries per day.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Exercise training
Description: Three 60-minute multimodal exercise sessions per week. Exercise interventions will be individualized to each participant based on their fitness level as per recommended guidelines for older adults. Each session will include a warm-up and cool-down (\~5 minutes each), 30 minutes of moderate intensity aerobic exercise and 20 minutes of moderate intensity resistance training.
Study: NCT06631833

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention measures based on the YPAP model.
Description: The intervention group received an 8-week intervention program aimed at gradually increasing their physical activity levels. The intervention program included the following components: 1) 1-2 sessions of moderate-intensity physical activity per week, each lasting 45 minutes, with activities provided by physical activity experts; 2) one health education lecture every two weeks, each lasting 60 minutes; and 3) one family physical activity session per week, each lasting 30 minutes at a lower intensity. At the end of the intervention period, relevant questionnaires were used for measurement.
Study: NCT04796285

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Lab Clasp
Description: Finger-based interstitial fluid assessment device
Study: NCT05448755

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ELX-02
Description: ELX-02 is a small molecule, new chemical entity being developed for the treatment of genetic diseases caused by nonsense mutations. ELX-02 is a eukaryotic ribosomal selective glycoside (ERSG).
Study: NCT06693804

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Digital Otoscope and Ophthalmoscope
Description: The otoscope and ophthalmoscope will be used by residents to examine the eyes and ears under illumination and magnification during physical examinations.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional otoscope and ophthalmoscope
Description: The otoscope and ophthalmoscope will be used by residents to examine the eyes and ears under illumination during physical examinations.
Study: NCT06693713

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mental Health Youth Series
Description: The Mental Health Youth Series is an eight-week program for youth ages 11-15 that uses games, short films, discussion questions, and exercises to engage with mental health and faith topics. The intervention package includes a facilitation guide and a guide for parents and caregivers. The program is intended to be conducted by an experienced facilitator, although there is no specific training provided for facilitators outside of the facilitation guide.
Study: NCT06692101

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: oral care
Description: We prepared the necessary tools and suction devices, then helped patients sit upright before starting oral care. Using a flashlight and toothbrush, we assessed the mouth and removed any food debris, aspirating saliva if needed. We cleaned the teeth using a toothbrush, dental floss, and an interdental brush with a small amount of fluoridated toothpaste. The Bass method was used for brushing. Finally, we cleaned the front two-thirds of the tongue with a damp toothbrush.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: oral care
Description: We prepared the necessary tools and suction devices, then helped patients sit upright before starting oral care. Using a flashlight and toothbrush, we assessed the mouth and removed any food debris, aspirating saliva if needed. We cleaned the teeth using a toothbrush, dental floss, and an interdental brush with a small amount of fluoridated toothpaste. The Bass method was used for brushing. Finally, we cleaned the front two-thirds of the tongue with a damp toothbrush.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Neuromuscular Electrical Stimulation (NMES)
Description: We used the VitalStim® device to deliver neuromuscular electrical stimulation (NMES). Before placing the electrodes, participants were asked to shave any facial hair and clean their neck skin with alcohol wipes. We positioned four electrode pads horizontally, above and below the hyoid bone. The device provided stimulation at a pulse rate of 80 Hz with a biphasic pulse duration of 300 microseconds. Each session lasted 30 minutes, with the intensity gradually increased in 0.5 mA intervals, based on the patient's comfort level, and adjusted to their maximum tolerance.
Study: NCT06692933

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cannabidiol in the form of hemp
Description: Cannabidiol (30 mg) in the form of an orally administered hemp oil softgel
Study: NCT04904913

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IBI362
Description: IBI362 administered subcutaneously (SC) once a week.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IBI362
Description: IBI362 administered subcutaneously (SC) once a week.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IBI362
Description: IBI362 administered subcutaneously (SC) once a week.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IBI362
Description: IBI362 administered subcutaneously (SC) once a week.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: placebo administered subcutaneously (SC) once a week.
Study: NCT06289764

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Bergamot Essential Oil
Description: Selected women will be smelled 3 times a day, at the same time every day, for 4 days, within 7 days before menstruation. Application will be repeated for 3 cycles.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Grapefruit Essential Oil
Description: Selected women will be smelled 3 times a day, at the same time every day, for 4 days, within 7 days before menstruation. Application will be repeated for 3 cycles.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Sweet almond oil
Description: Selected women will be smelled 3 times a day, at the same time every day, for 4 days, within 7 days before menstruation. Application will be repeated for 3 cycles
Study: NCT05805189

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: pulmonary vein (PV) isolation
Description: The settings used during ablation will be for both groups: 15W, unipolar; 5ml/min baseline irrigation, 35ml/min irrigation during inflation/RF application; 55°C target electrode temperature; RF application time 60s for anterior electrodes, 20s for posterior electrodes. The catheter insertion in Pulmonary vein and ablation workflow will be different for two groups.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: pulmonary vein (PV) isolation
Description: The settings used during ablation will be for both groups: 15W, unipolar; 5ml/min baseline irrigation, 35ml/min irrigation during inflation/RF application; 55°C target electrode temperature; RF application time 60s for anterior electrodes, 20s for posterior electrodes. The catheter insertion in Pulmonary vein and ablation workflow will be different for two groups.
Study: NCT05312658

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: External aortic compression
Description: External aortic compression by assistant in cesarean section.
Study: NCT06275074

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Dry Needling
Description: Insertion of filiform needles into cervicothoracic multifidi, upper trapezius, and suboccipital muscles

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Therapeutic Exercise
Description: Therapeutic exercise program provided to all participants with the aim of addressing periscapular strength and postural edurance.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Therapeutic Exercise
Description: Therapeutic exercise program provided to all participants with the aim of addressing periscapular strength and postural edurance.
Study: NCT05010005

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ruxolitinib
Description: Ruxolitinib 20mg BID

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Duvelisib
Description: Duvelisib 25mg, 50mg, or 75mg BID
Study: NCT05269082

Intervention type: OTHER
Intervention: No intervention
Description: This is a non-interventional study.

Intervention type: OTHER
Intervention: No intervention
Description: This is a non-interventional study.

Intervention type: OTHER
Intervention: No intervention
Description: This is a non-interventional study.
Study: NCT05359562

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Exposure & Response Prevention (EX/RP)
Description: Exposure and Response Prevention (EX/RP) is a type of Cognitive Behavioral Treatment for treating OCD. This is a brief protocol consisting of 8 sessions of exposure and Response Prevention (EX/RP). This protocol includes two psychoeducation/planning sessions, followed by six exposure sessions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exposure & Response Prevention (EX/RP)
Description: Exposure and Response Prevention (EX/RP) is a type of Cognitive Behavioral Treatment for treating OCD. This is a brief protocol consisting of 8 sessions of exposure and Response Prevention (EX/RP). This protocol includes two psychoeducation/planning sessions, followed by six exposure sessions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exposure & Response Prevention (EX/RP)
Description: Exposure and Response Prevention (EX/RP) is a type of Cognitive Behavioral Treatment for treating OCD. This is a brief protocol consisting of 8 sessions of exposure and Response Prevention (EX/RP). This protocol includes two psychoeducation/planning sessions, followed by six exposure sessions.
Study: NCT04416724

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Phacoemulsification
Description: Lens removal by Phacoemulsification

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Selective Laser Trabeculoplasty
Description: Laser application in trabecular meshwork
Study: NCT04817436

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: physical activity program (APA)
Description: adapted physical activity program (APA)

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: physical activity program (APA)
Description: adapted physical activity program (APA)
Study: NCT05078437

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Medication therapy management
Description: The proposed deprescribing intervention is using a patient-centered framework by: (1) balancing the risks and benefits, and addressing the specific needs of each individual patient, (2) considering the individual patient and the caregiver's preferences and values, and (3) empowering the patient and the caregiver to take responsibility and fully participate in the decision-making process as equal team players.