TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05820763

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selinexor
Description: Selinexor is administered by mouth on Days 1, 8, 15, and 22 at a dose of 60 mg during the four cycles of consolidation. Selinexor is then decreased to 40 mg and administered by mouth on Days 1, 8, 15, and 22 for up to 8 cycles of maintenance therapy.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selinexor
Description: Selinexor is administered by mouth on Days 1, 8, 15, and 22 at a dose of 60 mg during the four cycles of consolidation. Selinexor is then decreased to 40 mg and administered by mouth on Days 1, 8, 15, and 22 for up to 8 cycles of maintenance therapy.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide
Description: Lenalidomide is administered by mouth daily on Days 1 to 21 at a dose of 10 mg during the first three cycles of consolidation, and then titrated up to 15 mg on Days 1 to 21 for the fourth cycle of consolidation. Lenalidomide 15 mg by mouth daily on Days 1 to 21 can be continued for up to 8 cycles of maintenance therapy.~For patients with baseline renal dysfunction, the starting dose of lenalidomide will be 2.5 mg or 5 mg by mouth daily on Days 1 to 21. Patients may titrate up per physician discretion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide
Description: Lenalidomide is administered by mouth daily on Days 1 to 21 at a dose of 10 mg during the first three cycles of consolidation, and then titrated up to 15 mg on Days 1 to 21 for the fourth cycle of consolidation. Lenalidomide 15 mg by mouth daily on Days 1 to 21 can be continued for up to 8 cycles of maintenance therapy.~For patients with baseline renal dysfunction, the starting dose of lenalidomide will be 2.5 mg or 5 mg by mouth daily on Days 1 to 21. Patients may titrate up per physician discretion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: Dexamethasone is administered by mouth on Days 1, 8, 15, and 22 at a dose of 20 mg during all four cycles of consolidation only.
Study: NCT04773145

Intervention type: PROCEDURE
Intervention: Hemiarthroplasty with hydroaxyapatite coated stem
Description: Hemiarthroplasty with non cemented femoral stem, using the hydroxyapatite-coated femoral stem Pharo
Study: NCT04983615

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: fentanyl-based sedation
Description: fentanyl-based sedation instead of midazolam-based sedation in ventilated patients

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: midazolam-based sedation
Description: midazolam-based sedation
Study: NCT05610566

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: the HighLife Trans-Septal Transcatheter Mitral Valve Replacement System
Description: The HighLife TMVR system is composed of a Transcatheter Mitral Valve (TMV), a subannular implant (SAI), and their delivery systems and accessories. The TMV is a 28mm mitral bioprosthesis made of a self-expanding Nitinol frame covered with polyester graft and supporting bovine pericardium leaflets. The bioprosthesis is used in conjunction with the Sub-Annular Implant (SAI), comprising a ring (made of polycarbonate urethane (PCU), nitinol, gold markers and polyester (Dacron) to be placed around the mitral valve apparatus to stabilize the position of the mitral valve implant.
Study: NCT05786872

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: dual-target deep brain stimulation
Description: DBS electrodes will be implanted into the ALIC and the NAcc, electric stimulation of those areas are used to treat alcohol use disorder and to evaluate the efficacy and safety of DBS system.
Study: NCT06605716

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Enucleation of cysts
Description: Surgical removal of cystic structures larger than 1 cm in patients included in the study arms. Patients were monitored for TCR during the procedure.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Enucleation of cysts
Description: Surgical removal of cystic structures larger than 1 cm in patients included in the study arms. Patients were monitored for TCR during the procedure.
Study: NCT06605547

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Non-surgical periodontal treatment
Description: The non-surgical periodontal treatment (scaling and root planing) was applied under local anesthesia using ultrasonic device and Gracey curettes. After scaling and root planing, periodontal pockets were irrigated using saline solution. Non-surgical periodontal treatment was completed in one or two sessions within 24 hours.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Non-surgical periodontal treatment
Description: The non-surgical periodontal treatment (scaling and root planing) was applied under local anesthesia using ultrasonic device and Gracey curettes. After scaling and root planing, periodontal pockets were irrigated using saline solution. Non-surgical periodontal treatment was completed in one or two sessions within 24 hours.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Subgingival application of saline
Description: For the subgingival saline application at the control sites, the insulin needle was filled with saline and the 29-gauge needle tip was gently placed into the periodontal pocket. The saline was injected into the periodontal pocket until it was seen to overflow from the gingival margin. Subgingival saline application was repeated on the 7th day.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Subgingival application of i-PRF
Description: For subgingival application of i-PRF at the test sites, the i-PRF taken into the insulin syringe, the 29-gauge needle tip was gently placed into the periodontal pocket and the i-PRF was injected into the periodontal pocket until it reached the gingival margin (until it overflowed from the sulcus). Subgingival i-PRF application was repeated on the 7th day.
Study: NCT06658951

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Anti-HER2 CAR-T cells
Description: All eligible participants will receive a conditioning chemotherapy regimen of fludarabine, cyclophosphamide and ABRAXANE followed by Anti-HER2 CAR-T cell injection.
Study: NCT04824768

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Tecar Therapy
Description: CRet is a non-invasive diathermy technique that provides high frequency energy generating a thermal effect on soft tissues. Functional massage (FM) is a non-invasive manual therapy technique that combines rhythmical passive joint mobilization with compression of the muscular belly with the muscle-tendon insertions to be treated.~In prone position, subjects will get a 7 min preparation massage with CRet on resistive mode (80-100W), on the lumbar area, followed by a 5 min preparation massage with CRet on resistive mode (100-120 W) on the hamstrings. Then a 5 min F.M with passive ankle dorsiflexion and CRet on resistive mode (110-120 W) will be performed on the gastrocnemius medialis and lateralis, followed by a 4 min FM with CRet on capacitive mode (180-250VA) on the mentioned area.~In supine position, a 5 min FM with passive knee flexion and CRet on resistive mode 8.~A physiotherapist will monitor the temperature of the patient's treated area every 2 minutes

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Tecar Therapy
Description: In prone position, subjects will get a 7 min preparation massage with CRet on resistive mode (0 W), on the lumbar area, followed by a 5 min preparation massage with CRet on resistive mode (0 W) on the hamstrings. Then a 5 min FM with passive ankle dorsiflexion and CRet on resistive mode (0 W) will be performed on the gastrocnemius medialis and lateralis, followed by a 4 min FM with CRet on capacitive mode (0 VA) on the mentioned area.~In supine position, a 5 min FM with passive knee flexion and CRet on resistive mode 0.~A physiotherapist will monitor the temperature of the patient's treated area every 2 minutes
Study: NCT06605768

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Complex with Biotin, Collagen, Keratin, Hyaluronic Acid.
Description: Biotin, Collagen \&amp;amp; Keratin Beauty Complex 25,000 mcg, 60 capsules, oral route of administration.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo product
Description: Placebo, 60 capsules, oral route of administration
Study: NCT06607510

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental HIIT
Description: Subjects belonging to this group perform a 12-week supervised exercise (3 sessions weekly spaced at least 48 hours apart with a maximum duration of 40 minutes), followed by 12 weeks of detraining follow-up. Before starting the intervention, two familiarization sessions for assessing strength and functional capacity will be conducted. This program is designed in a standardized warm-up: joint mobility exercises and neuromuscular activation (5 minutes). Main part os the training is design in treadmill walking exercise (28 minutes). Participants must complete four four-minute blocks at an intensity of 85-95% of peak heart rate.The initial starting speed is 5 km/h and adjust the intensity with incline increments of 2%. Between sets, a prescribed active rest period lasts three minutes, during which patients walk on the treadmill at an intensity of 60-70% of peak heart. The last part of the training is a cool-down (5 minutes treadmill walking at an intensity of 50-60% of peak heart rate).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental HIFT
Description: Subject belonging to this group perform a 12-week supervised exercise (3 sessions weekly spaced at least 48 hours apart with a maximum duration of 40 minutes), followed by 12 weeks of detraining follow-up. Before starting the intervention, two familiarization sessions for assessing strength and functional capacity will be conducted. AMRAP will consist of a circuit of six global, functional exercises with external loads \[i) squat; ii) rowing; iii) dead weight; iv) chest press; v) step up; vi) farmer walk\]. Patients will perform 10 repetitions of each exercise and complete as many rounds as possible within the specified time. Between blocks, there will be a prescribed active rest period lasting three minutes, during which patients will walk on the treadmill at an intensity of 60-70% of peak heart rate. The last part of the training is a cool-down (5 minutes treadmill walking at an intensity of 50-60% of peak heart rate).
Study: NCT06608641

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Endoxifen enteric-coated tablet (8 mg)
Description: Patients will continue treatment with their initial randomized medication for 3 weeks

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Tablets
Description: Patients will be treated with Endoxifen Placebo Tablets for 21 days
Study: NCT06607328

Intervention type: OTHER
Intervention: Assessment of participants in terms of different aspects.
Description: This group was composed of individuals who have the prehypertensive stage.

Intervention type: OTHER
Intervention: Assessment of participants in terms of different aspects.
Description: This group was composed of individuals who have the prehypertensive stage.
Study: NCT06608745

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: conventional total knee arthroplasty
Description: total knee arthroplasty performed with conventional technique

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: computer-assisted total knee arthroplasty
Description: total knee arthroplasty performed with imageless computer-assisted surgery
Study: NCT06608433

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: semaglutide
Description: semaglutide/Rybelsus will be administered as a single oral dose

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo pills will be administered as a single oral dose
Study: NCT06607874

Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-Interventional study

Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-Interventional study
Study: NCT06608576

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Face-to-face standard treatment
Description: Individualized early intervention treatment on physical therapy area as usual in the early intervention facilities once a month for two months. Instructions will be given to the parents for follow-up at home to stimulate the baby's motor development until next face-to-face session.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Telematic Support
Description: The physiotherapist in charge of the telematic sessions will review and guide in real time through WhatsApp platform, the performance and active participation of the parents in the therapeutic activities being asked to follow-up at home in the face-to-face appointment, correcting, as necessary.
Study: NCT06608719

Intervention type: BIOLOGICAL
Intervention: The study drug is SHED-CM manufactured by U-Factor
Description: Patients diagnosed with ALS were administered SHED-CM
Study: NCT06605248

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: App-based self-management tool plus usual care
Description: The app-based self-management tool will be delivered after patients receive usual care from their general practitioners. The 8-week mobile app intervention will involve daily sessions on pain education and clinical hypnosis for back pain management (5 minutes, 15 minutes of listening to hypnotherapy audio and engaging in physical/social activities for 5 minutes.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Patient information digital fact-sheet plus usual care
Description: The face-sheet will be delivered after patients receive usual care from their general practitioners.This digital intervention will contain educational material for chronic back pain that includes details about diagnosis, prognosis and treatment options.
Study: NCT06606132

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise
Description: The virtual reality program consisted of twelve sessions (2 per week for six weeks) of 10 min warm-up plus 15 minutes of exercise with the FitXR game (developed by FITAR LIMITED) on the Oculus Quest 2™ device. The warm-up consisted of moderate-intensity aerobic exercise on a cycle ergometer. The BORG CR-10 perceived exertion scale was used to determine this intensity. Subsequently, they continued with the FitXR game, starting with a 5-minute phase of muscular activation and global movements of their limbs. They performed eye-hand coordination exercises, hitting balls that came to the person at different speeds, and ended with muscle stretching and slow breathing. These exercises presented different difficulty levels and were adjusted to the person\&#39;s condition. In the same way, as the game developed, it was possible to increase the level and thus increase its complexity.
Study: NCT06604533

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intervention: MRI-Linac SABR
Description: The treatment planning protocol follows the UK SABR Consortium Guidelines. Patients will be prescribed the maximum isotoxic dose achievable while meeting normal organ tolerances (normal liver, kidney, spinal cord, stomach, duodenum, small and large bowel, heart, lungs, chest wall). The lowest acceptable SABR doses are indicated in the dose range Table within the protocol. The maximum dose/fraction also indicates the maximum the dose can be escalated to for each adaptive session on the MRI-Linac.
Study: NCT05135403

Intervention type: DEVICE
Intervention: Defibrillation
Description: External defibrillation from a wearable cardioverter defibrillator
Study: NCT05070026

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: uni-portal VATS group
Description: patients received pulmonary lobectomy under general anesthesia by using uni-portal VATS method

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: three port VATS group
Description: patients received pulmonary lobectomy under under general anesthesia by using three port VATS method
Study: NCT06378463

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive remediation + active tDCS
Description: The cognitive remediation program Computerised Interactive Remediation of Cognition - a Training for Schizophrenia (CIRCuiTS) improves cognitive and metacognitive skills and strategies and is specifically aimed at the generalization of newly learnt skills to daily life. This method also offers the possibility to personalize the training program based on individual goals and cognitive functioning of the service user.~Transcranial Direct Current Stimulation is used to promote neural plasticity, which applies a small electrical current over the cortex. This can alter the excitability of neurons, such that it increases or decreases spontaneous network activity. When applied to fronto-parietal neural networks simultaneously with their engagement in cognitive tasks of CIRCuiTS, it is expected that plasticity of these networks will be modulated, resulting in improvements in cognitive functioning.~In this condition, participants will receive active brain stimulation.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Cognitive remediation + sham tDCS
Description: The cognitive remediation program Computerised Interactive Remediation of Cognition - a Training for Schizophrenia (CIRCuiTS) improves cognitive and metacognitive skills and strategies and is specifically aimed at the generalization of newly learnt skills to daily life. This method also offers the possibility to personalize the training program based on individual goals and cognitive functioning of the service user.~Transcranial Direct Current Stimulation is used to promote neural plasticity, which applies a small electrical current over the cortex. This can alter the excitability of neurons, such that it increases or decreases spontaneous network activity. When applied to fronto-parietal neural networks simultaneously with their engagement in cognitive tasks of CIRCuiTS, it is expected that plasticity of these networks will be modulated, resulting in improvements in cognitive functioning.~In this condition, participants will receive sham brain stimulation.
Study: NCT05606497

Intervention type: DRUG
Intervention: Corticosteroid
Description: Antenatal corticosteroids are administered to pregnancies at risk for preterm birth in order to reduce risks of neonatal morbidity and mortality following preterm birth.
Study: NCT04710979

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Yoga Intervention
Description: This group will have in-person, 60 minute yoga sessions three times per week for 12 weeks. These sessions will also include a sharing circle to provide group feedback as to how the practice felt and integration into ones' daily life. There will be biweekly themes established for these sessions (i.e. common yoga poses, importance of breath) and biweekly in-person workshops will be offered. These will be specialty classes for participants to experience additional exposure to meditation and breathing. They will be a longer format so participants can delve deeper into yogic philosophy and practice. There will also be a private Facebook group for participants to connect with each other and for the research staff to maintain contact and share information with the participants (eg. weekly reminder for yoga sessions and workshops).
Study: NCT05132049

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DA-5211
Description: single dose administration (DA-5211 one tablet once a day)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DA-5211
Description: single dose administration (DA-5211 one tablet once a day)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DA-5211-R1 + DA-5211-R2
Description: single dose administration (DA-5211-R1 one tablet once a day + DA-5211-R2 one tablet once a day)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DA-5211-R1 + DA-5211-R2
Description: single dose administration (DA-5211-R1 one tablet once a day + DA-5211-R2 one tablet once a day)
Study: NCT04433780

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doravirine/Lamivudine/Tenofovir Disoproxil Fumarate
Description: DOR/3TC/TDF 100/300/300 mg once daily fixed-dose combination switched from either EFV/TDF/FTC or DTG/TDF/3TC
Study: NCT05150093

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Deep Brain Stimulation
Description: Clinically indicated DBS treatment for dystonia or tremor with simultaneous research electrocorticography (ECoG).
Study: NCT05889910

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Health education workshop
Description: The intervention will consist of 5 initial sessions, plus a reinforcement session at 6 months. The sessions will last 2 hours and will preferably be distributed one day a week.~The objective of the intervention is to reduce the fear of falling and falls in people over 65 years of age who live in the community. To this end, nursing interventions will be included to improve the knowledge, skills and attitudes of the participants regarding the improvement of their functional capacity, the prevention of falls and their preventive measures, as well as the improvement in the management of anxiety and coping with the fear of falling and falls.~The activities carried out during the intervention have been extracted from standardized nursing interventions through the Nursing Interventions Classification (NIC).~The following interventions and activities will be addressed: 1665, 5612, 6490, 6486, 4700, 5820 and 5230.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Health education workshop
Description: The intervention will consist of 5 initial sessions, plus a reinforcement session at 6 months. The sessions will last 2 hours and will preferably be distributed one day a week.~The objective of the intervention is to reduce the fear of falling and falls in people over 65 years of age who live in the community. To this end, nursing interventions will be included to improve the knowledge, skills and attitudes of the participants regarding the improvement of their functional capacity, the prevention of falls and their preventive measures, as well as the improvement in the management of anxiety and coping with the fear of falling and falls.~The activities carried out during the intervention have been extracted from standardized nursing interventions through the Nursing Interventions Classification (NIC).~The following interventions and activities will be addressed: 1665, 5612, 6490, 6486, 4700, 5820 and 5230.
Study: NCT06207617

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Immediate implant placement + customized healing abutment
Description: Immediate implant placement in fresh extraction molar sites + customized healing abutment fabricated by adding flowable composite to the temporary cylindrical abutment mimicking the shape of the socket at the marginal gingiva, then it will be screwed to the implant. no grafting material included in this arm

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Immediate implant placement + xenogeneic bone graft material + customized healing abutment
Description: Immediate implant placement in fresh extraction molar sites + xenogenic bone graft + customized healing abutment fabricated by adding flowable composite to the temporary cylindrical abutment mimicking the shape of the socket at the marginal gingiva, then it will be screwed to the implant.
Study: NCT04900220

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Betamethasone
Description: The volume of the doses of steroid to be given will be standardized to 1 injection of 1 cc of betamethasone (6 mg)