TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04729231

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Nasalis Sling Flap
Description: The nasalis sling flap involves alteration of the nasalis muscle to create a myocutaneous pedicle flap that will be used to fill in the wound.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Lobed Transposition Flap
Description: Lobed flap reconstruction involves the use of cutaneous tissue located adjacent to the nasal tip to fill in the wound. The flap will undergo a 90-degree arc to approximate the desired position.
Study: NCT05141955

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Group Erector Spinae Plane Block (ESPB)
Description: Patients will receive general anesthesia initially then bilateral ESPB with a total volume of (0.3-0.4 ml/kg LBW) of bupivacaine 0.25% will be performed (not exceeding toxic dose) 150 mg

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Group Quadratus Lumborum Block (QLB)
Description: Patients will receive general anesthesia initially then bilateral QLB with a total volume of (0.3-0.4 ml/kg LBW) of bupivacaine 0.25% will be performed not exceeding toxic dose150 mg

Intervention type: OTHER
Group type: OTHER
Intervention: Group (C) (Control group)
Description: Where patients will be operated under general anesthesia.
Study: NCT05363826

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: photochemotherapy using 3-(1-Butyloxy)ethyl-3-deacetyl-bacteriopurpurin-18-n-butylimide methyl ester(Photobac®)
Description: Intravenous injection of Photobac® 24 hours before surgical removal of recurrent GBMF.~Immediately after resection, the cavity will be treated with 50 joules/ square cm of 787nm light. This treatment will add a maximum of 50 minutes to the surgery
Study: NCT06194071

Intervention type: OTHER
Intervention: Completion of questionnaires and on-site visits during an 18 months follow-up after TBI
Description: We will evaluate the same outcomes and use the same questionnaires at 6, 12 and 18 months post-TBI.~For patients we will evaluate:~* Functional Outcome (GOS-Extended)~* Health-related Quality of Life (QOLIBRI)~* Neurocognitive tests (MoCA)~* Independence (Barthel Index)~* Daily issues (BICOQ)~* Anxiety and depression symptoms (HADS)~* Medico-economic evaluation (EQ5D-5L)~For Relatives we will evaluate:~* Symptoms of anxiety and depression (HADS)~* The appreciation of the patient's daily issues from their point of view (dedicated Bicoq for relatives)~* Burden of care (ZARIT)~Throughout the follow-up we will nest a qualitative research programs which will focus on several aspects:~* feasibility of such follow-up (6 months is the primary endpoint) defined as the drop-out rate, complete or incomplete completion of scales and their reasons~* factors that may lead to drop-out or the contrary that solidifies the follow-up
Study: NCT05633329

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: single level
Description: injection of 40 ml bupivacaine 0.25 at T8 (20 ml on each side)

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: dual level
Description: injection of 40 ml of bupivacaine 0.25 at two level T7 and T9 (10 ml on each level of both side)
Study: NCT05883722

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Catheter ablation
Description: The ablation approach includes: pulmonary vein isolation, left side linear ablation, left side driver ablation and right atrial driver ablation

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Catheter ablation
Description: The ablation approach includes: pulmonary vein isolation, left side linear ablation, left side driver ablation and right atrial driver ablation
Study: NCT06172946

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: powerbreath
Description: Previous studies have confirmed the efficacy of implementing IMT as part of a RR program in a certain profile of patients with COPD, showing improvements in maximum inspiratory pressure, perception of well-being, and other respiratory diseases, and dyspnea during exercise. (Gandullo et al., 2022)

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: TRANSCUTANEOUS ELECTRICAL DIAPHRAGMATIC STIMULATION
Description: Transcutaneous electrical diaphragmatic stimulation (TEDS) has been used to improve respiratory muscle strength in patients with respiratory muscle weakness. A previous study reported that patients with chronic obstructive pulmonary disease (COPD) showed increased lung volume and oxygen saturation after a single session of TEDS. (Hsin et al., 2022)
Study: NCT05516316

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: EP395
Description: Capsule for oral use

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: EP395
Description: Capsule for oral use

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Capsule for oral use
Study: NCT06025656

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Leg Lateral Reach Test
Description: To conduct the leg reach test, participants began by positioning themselves with their arms hanging at their sides. They were then guided to raise the leg under assessment and extend it across the opposite leg to make contact with a wooden bar, employing trunk rotation in the process. During each trial, participants were consistently motivated to ensure that both shoulders remained in contact with the floor and to stretch their tested leg as far as they could along the length of the wooden bar. If a participant was unable to sustain contact between their foot and the wooden bar for a duration of 5 seconds at the point of maximal reach, or if both shoulders lifted off the floor, that specific trial was considered invalid and not included in the analysis.~Each participant completed three repetitions of this test for both the right and left sides, and the average of their reach distances was subsequently calculated for assessment.
Study: NCT04686539

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CBD
Description: CBD oil not containing THC, to be administered sub-lingual.
Study: NCT05783687

Intervention type: DIAGNOSTIC_TEST
Intervention: NCC-Sp Assay
Description: Orphalan has developed a new NCC speciation assay (NCC-Sp) using liquid chromatography inductively coupled plasma mass spectroscopy (LC-ICP-MS) to measure serum copper and ceruloplasmin bound copper from which non ceruloplasmin bound copper (NCC) is estimated.

Intervention type: DIAGNOSTIC_TEST
Intervention: NCC-Sp Assay
Description: Orphalan has developed a new NCC speciation assay (NCC-Sp) using liquid chromatography inductively coupled plasma mass spectroscopy (LC-ICP-MS) to measure serum copper and ceruloplasmin bound copper from which non ceruloplasmin bound copper (NCC) is estimated.

Intervention type: DIAGNOSTIC_TEST
Intervention: NCC-Sp Assay
Description: Orphalan has developed a new NCC speciation assay (NCC-Sp) using liquid chromatography inductively coupled plasma mass spectroscopy (LC-ICP-MS) to measure serum copper and ceruloplasmin bound copper from which non ceruloplasmin bound copper (NCC) is estimated.

Intervention type: DIAGNOSTIC_TEST
Intervention: NCC-Sp Assay
Description: Orphalan has developed a new NCC speciation assay (NCC-Sp) using liquid chromatography inductively coupled plasma mass spectroscopy (LC-ICP-MS) to measure serum copper and ceruloplasmin bound copper from which non ceruloplasmin bound copper (NCC) is estimated.
Study: NCT06008509

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Gastric echography preoperative
Description: Patients with acute abdomen that are going to surgery, are going to recieve a gastric echography in the surgery room before the start of anesthesia. This procedure include vision of the stomach during supine position and lateral position with curve transductor.
Study: NCT05755009

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: High- and Low-dose radiotherapy
Description: High- and Low-dose radiotherapy combined with immunotherapy and maintain immunotherapy. Immunotherapy (Envafolimab) once every week (maintain a total of two years). Continuous high-(8Gy×5F) and low-dose (1.33Gy×5F) Radiotherapy starts at the second week after immunotherapy.
Study: NCT04686539

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo Oil
Study: NCT05885737

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Difelikefalin Injection
Description: Participants receive Difelikefalin three times a week (0,5 micrograms/kg dry body weight). Difelikefalin is administered by intravenous bolus injection into the venous line of the dialysis circuit at the end of each dialysis.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Difelikefalin Injection
Description: Participants receive Difelikefalin three times a week (0,5 micrograms/kg dry body weight). Difelikefalin is administered by intravenous bolus injection into the venous line of the dialysis circuit at the end of each dialysis.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Injection
Description: Participants receive Placebo three times a week (0,5 micrograms/kg dry body weight). Placebo is administered by intravenous bolus injection into the venous line of the dialysis circuit at the end of each dialysis.
Study: NCT05011110

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Graduated compression stockings
Description: Both GraduSOX and Sigvaris are graduated compression stockings. These exert the greatest degree of of compression at the ankle, and the level of compression gradually decreases up the garment.
Study: NCT04614129

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Low Dose CT
Description: All participants will have a low dose chest CT either within one year of enrollment or after enrollment
Study: NCT05860673

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: mini invasive scoliosis surgery
Description: The minimally invasive technique, involves two small median skin incisions that allow the deep structures to be exposed. The muscle fibers are separated from the bony insertion by the process of subperiosteal skeletonization. The Investigators then proceed with the arthrectomy of the levels to be instrumented and the infiltration of pedicle screw pairs of the appropriate caliber according to the free-hand technique. After amplioscopic control of proper screw placement, osteotomies of the posterior elements are performed to facilitate correction of the metameres.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: posterior spinal fusion technique
Description: The standard open technique involves a longitudinal incision along the midline extended along the entire thoracolumbar spine, the paravertebral muscles are incised and spread apart to expose the posterior vertebral structures, in a stretch extending more than 30 cm. The series of facetectomies are performed first, and then pairs of pedicle screws are infixed freehand.~After performing the osteotomies necessary to mobilize the vertebral metameres at the apex of the deformity, correction by derotation maneuvers is continued, and the obtained correction is fixed with pre-shaped bars that are then connected to the screws and tightened to the nuts by dynamometric technique. Almost all vertebral levels of the thoracolumbar tract are included in the arthrodesis
Study: NCT06301906

Intervention type: DRUG
Intervention: LipoCol Forte Capsule 600mg bid
Description: LipoCol Forte Capsule 600mg bid for 12 months
Study: NCT05665725

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT scan

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo PET scan

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Siltuximab
Description: Given IV
Study: NCT06459492

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: puzzle game strategies
Description: One innovative approach uses puzzle game strategies, including crosswords, Sudoku, and other brain-teasing activities. These strategies have been shown to help maintain attention, improve memory, and keep older adults' thoughts clear and sharp. Additionally, engaging in these activities can provide psychological benefits by offering a sense of achievement, reducing stress, and fostering social interactions.~Given puzzle games' potential to enhance cognitive and psychological health, exploring their effectiveness as a non-pharmacological intervention for community-dwelling older adults is essential. This research aims to fill the gap by empirically investigating the impact of puzzle game strategies on cognitive functioning and psychological well-being in this demographic.
Study: NCT06581653

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Phone-based PERT education intervention
Description: Participants who allocate to the intervention group will receive regular phone-based PERT education intervention by professional team.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Phone-based PERT education intervention
Description: Participants who allocate to the intervention group will receive regular phone-based PERT education intervention by professional team.
Study: NCT05725863

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mindfulness-Based Cognitive Therapy
Description: Mindfulness-Based Cognitive Therapy (MBCT) is a structured group intervention developed by Segal et al. (2002). The intervention consisted of eight weekly 2.5-hr sessions and one 3-hr silent session. First, psycho-education focused on the importance of recognizing personal feelings and the relationship between stress, postpartum blues, mother-infant attachment and breastfeeding symptoms, and stress management, stress, postpartum blues, mother-infant attachment and breastfeeding. Additionally, postpartum mothers' experiences of stress, postpartum blues, mother-infant attachment, and breastfeeding were central during the study and were a recurring topic for the purpose of the study in general. Postpartum mothers were given homework assignments, including audio CDs with formal exercises, and were asked to practice for 30 min per day.
Study: NCT04283019

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CBD
Description: CBD will be orally ingested

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CBD
Description: CBD will be orally ingested

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CBD
Description: CBD will be orally ingested

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: THC
Description: THC will be orally ingested

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: THC
Description: THC will be orally ingested
Study: NCT05550506

Intervention type: DRUG
Intervention: Duloxetine
Description: Patients who use duloxetine for chronic pain or fibromyalgia
Study: NCT05662839

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cytological Brushing
Description: All participants will undergo cytological brushing to collect cell samples for analysis
Study: NCT05376644

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 99mTc-ADAPT6
Description: One single injection of 99mTc-ADAPT6, followed by gamma camera imaging 2 hours after injection.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 99mTc-DARPinG3
Description: One single injection of 99mTc-DARPinG3, followed by gamma camera imaging 4 hours after injection.
Study: NCT05583825

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rebozo App
Description: It is a non-invasive, non-drug practical application made with Rebozo, a long and colorful fabric, two meters long and 70 cm wide, worn by Mexican women on their head and shoulders.
Study: NCT05329207

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Experimental group
Description: Web Based Adolescent Health Promotion Education Program
Study: NCT05855343

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: BIDI Stick e-cigarette
Description: The BIDI will be dispensed, and subjects will be instructed to use the BIDI as often as they like during the 12 week period, and to switch completely to the BIDI within 1 week. If, however, they do smoke any CC, they will also be instructed to use the BIDI immediately before each CC to relieve their craving as much as possible before smoking their usual brand. The BIDI will also be the first product that they are instructed to use each morning. Smokers will be told to try to completely substitute BIDI for CCs by the end of the first week of use.
Study: NCT05026853

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PRO Integration into Clinical Practice
Description: HCPs will document their discussion and recommendations/referrals in MiChart (Epic EMR)
Study: NCT05896813

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CMOP+Chidamide
Description: Cyclophosphamide: 750 mg/m2, d1; Mitoxantrone Hydrochloride Liposome: 20 mg/m2, d1; Vincristine: 1.4 g/m2, d1 (maximum dose of 2 mg), or vindesine 3 mg/m2, d1; Prednisone: 60 mg/m2, d1-d5; Chidamide:20 mg, biw. The treatment is administered every 3 weeks as a cycle and lasts for a total of 6 cycles.
Study: NCT06137235

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: cows milk infant formula and follow-on formula with bioactive ingredients
Description: infant formula and follow-on formula with bioactive ingredients
Study: NCT04383275

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: capecitabine and trastuzumab
Description: In IRIS-A cohort, patients who met the inclusion criteria(ER，PR\<10%, T≤2cm or ER,PR ≥10% 1cm\<T≤2cm）would be given capecitabine for 6 cycles with standard trastuzumab for 1 year, in which HR+ patients would be given endocrine therapy for 5 years.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: endocrine therapy and trastuzumab
Description: In IRIS-B cohort, patients who met the inclusion criteria(ER,PR ≥10% T≤1cm) would be given endocrine therapy (premenopausal: tamoxifen or toremifene; postmenopausal: letrozole or anastrozole or exemestane) combined with standard trastuzumab for 1 year and complete endocrine therapy for 5 years.
Study: NCT06407102

Intervention type: OTHER
Group type: OTHER
Intervention: Collection of nasal cells during programme surgery
Description: During programmed surgery (meatotomy, septoplasty or turbinoplasty for example, or other programmed surgeries), the surgeon will take an atraumatic sample from the nasal cavity using a dedicated device (brush) from the healthy nasal mucosa.
Study: NCT06307236

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Emotional Freedom Techniques
Description: Emotional Freedom Technique (EFT), which is included in the energy psychotherapy similar to the cognitive behavioral therapy method, is an easily applicable method that is used to relieve mental problems such as anxiety and stress and has positive results, which has just started to be used in the world and in our country. EFT can be applied safely to all ages and groups.
Study: NCT06137235

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: standard cows milk infant formula and follow-on formula
Description: standard cows milk infant formula and follow-on formula
Study: NCT05503888

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Almonertinib combined with SHR-1701
Description: Phase Ⅰb/Phase Ⅱ：~SHR-1701: injection, intravenous infusion~Almonertinib: tablets, oral

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Almonertinib
Description: Phase Ⅱ:~Almonertinib: tablets, oral
Study: NCT05891158

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fazirsiran
Description: Fazirsiran SC injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fazirsiran
Description: Fazirsiran SC injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fazirsiran
Description: Fazirsiran SC injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fazirsiran
Description: Fazirsiran SC injection
Study: NCT06508242

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cholecalciferol
Description: cholecalciferol

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo
Study: NCT04764110

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Cyplexinol
Description: partially hydrolyzed Collagen and its associated proteins including Bone Morphogenetic Proteins (BMPs)

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Maltodextrin
Study: NCT05772910

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: EDUcation
Description: The education intervention will consist of an individualized educative program based on intrinsic capacity optimization through lifestyle changes. To develop the program, the program creation team will be multidisciplinary (psychologists, medical doctor, dietitian...) and will discuss goal setting, the education strategy, and retention of motivation. The experts are required to create the education program such that the participants can manage their health by themselves. The goal will be self-management of dietary habits and increases in physical activity levels for each individual case. The education program will be in Spanish or in English; as it will consist in personal counselling, even with a low level of the language the communication will be possible. The nutritional education program will be conducted every 2 weeks for 10 consecutive weeks, with 20-min counselling sessions by an expert.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: EXERcise
Description: The intervention period will have 10 weeks, in which the EXER group will carry out 2-3 sessions a week (total of 20-30 sessions). In this concurrent program, exercises of the lower extremities (leg press, abduction and plantar flexion) will be performed mainly on weight training machines. Intensity in each exercise will be individualized for each participant through a test to determine muscle power. In addition, in the last part of each session the participants will perform an endurance training type high insensitive interval training on a cycle ergometer (60-80 rpm). The intensity will be individualized to each patient through an incremental stress test until volitional exhaustion, and the subjects will alternate intervals of 30 seconds at 90% of the maximum workload, with intervals of 90 seconds at 40% of the maximum. Each session is estimated to have a total duration of 30-50 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: EDU-EXER
Description: This group will carry out the same two previous interventions together.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: CONtrol
Description: CONtrol group will continue the usual clinical treatment and their normal life