TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06439095

Intervention type: GENETIC
Intervention: Salivary Collection
Description: Expression levels of IL-2, IL-5 and IL-17 in the saliva of individuals aged 7-13 years who underwent stainless steel crown will be recorded before and after the procedure. Before the saliva sample collection procedure, the patient will be asked to rinse their mouth with sterile water and then spit into sterile plastic cups. After collecting approximately 3 ml of saliva, the saliva will be transferred to appropriate eppendorfs and stored at -40 degrees Celsius. For the second post-procedure, the same algorithms will be applied for saliva collection seven days after the crown procedure.

Intervention type: GENETIC
Intervention: Salivary Collection
Description: Expression levels of IL-2, IL-5 and IL-17 in the saliva of individuals aged 7-13 years who underwent stainless steel crown will be recorded before and after the procedure. Before the saliva sample collection procedure, the patient will be asked to rinse their mouth with sterile water and then spit into sterile plastic cups. After collecting approximately 3 ml of saliva, the saliva will be transferred to appropriate eppendorfs and stored at -40 degrees Celsius. For the second post-procedure, the same algorithms will be applied for saliva collection seven days after the crown procedure.

Intervention type: DIAGNOSTIC_TEST
Intervention: Ph and ion level measurement of saliva
Description: Salivary concentration of nickel, chrome, cobalt and palladium ions will be measured using an atomic absorption spectrophotometer. Salivary pH will be measured with the help of a digital pH meter

Intervention type: DIAGNOSTIC_TEST
Intervention: Ph and ion level measurement of saliva
Description: Salivary concentration of nickel, chrome, cobalt and palladium ions will be measured using an atomic absorption spectrophotometer. Salivary pH will be measured with the help of a digital pH meter
Study: NCT06272994

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: MRSA Nasal Swab PCR
Description: For the subjects assigned to the intervention group who have a negative MRSA nasal swab PCR result, providers will receive a pager alert which inform them of the negative result and will direct clinicians to clinical guidance recommending clinicians to discontinue vancomycin, if clinically appropriate.
Study: NCT06272799

Intervention type: DRUG
Intervention: T-DM1 adjuvant
Description: Evaluate the tolerability of treatment with adjuvant T-DM1 after failure to respond complete pathology to neoadjuvant treatment in terms of adverse events

Intervention type: DRUG
Intervention: T-DM1 adjuvant
Description: Evaluate the tolerability of treatment with adjuvant T-DM1 after failure to respond complete pathology to neoadjuvant treatment in terms of adverse events
Study: NCT06005051

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dietary intervention
Description: Using different combination of foods to see if the glucose response to a load of carbohydrates can be mitigated.
Study: NCT05673928

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trastuzumab emtansine
Description: Given by IV (vein)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tucatinib
Description: Given by PO
Study: NCT06296953

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: PERIsign examination
Description: Patients will be examined with the new device, PERIsign

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: PERIsign examination
Description: Patients will be examined with the new device, PERIsign
Study: NCT06294795

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: congenital/pediatric cataract surgery
Description: All procedures are performed under general anesthesia according to the standard technique of congenital/pediatric cataract surgery with an intraocular lens (IOL) implantation. Paracentesis is performed at 2.30 o\&#39;clock using a 20-gauge straight microvitreoretinal (MVR) knife; a high molecular weight ophthalmic viscosurgical devices (OVD) is injected into the anterior chamber. Then a 2.4 mm corneal tunnel incision is made at 11 o'clock with a disposable keratome knife 2.2 mm. Circular continuous capsulorhexis (≈ 5.5 mm). Сortical cleaving hydrodissection is followed by bimanual phacoaspiration in irrigation-aspiration mode. OVD is injected in the anterior chamber and an IOL is implanted in the capsular bag. Residual OVD is aspirated from the anterior chamber and behind the IOL and followed by IOL alignment. The surgery is completed with corneal hydration at the tunnel incision site.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: congenital/pediatric cataract surgery
Description: All procedures are performed under general anesthesia according to the standard technique of congenital/pediatric cataract surgery with an intraocular lens (IOL) implantation. Paracentesis is performed at 2.30 o\&#39;clock using a 20-gauge straight microvitreoretinal (MVR) knife; a high molecular weight ophthalmic viscosurgical devices (OVD) is injected into the anterior chamber. Then a 2.4 mm corneal tunnel incision is made at 11 o'clock with a disposable keratome knife 2.2 mm. Circular continuous capsulorhexis (≈ 5.5 mm). Сortical cleaving hydrodissection is followed by bimanual phacoaspiration in irrigation-aspiration mode. OVD is injected in the anterior chamber and an IOL is implanted in the capsular bag. Residual OVD is aspirated from the anterior chamber and behind the IOL and followed by IOL alignment. The surgery is completed with corneal hydration at the tunnel incision site.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Non-Toric IOLs
Description: A folding hydrophobic acrylic IOLs AcrySof IQ SN60WF and Clareon SY60WF for the non-toric group (Alcon Laboratories, Inc.) ARE implanted.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Toric IOLs
Description: A folding hydrophobic acrylic IOLs AcrySof IQ Toric SN6ATx and Clareon Toric CNW0Tx for the toric group (Alcon Laboratories, Inc.) were implanted.
Study: NCT06549998

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Interprofessional Simulation Experience
Description: Phase 1 (Pre-Brief): Nursing and physical therapy students will have 10 minutes to gather as a group and prepare for the simulation experience.~The students will work together to review the simulated patient's medical chart, which includes a hand off report, physician orders, patient demographic data, disci-pline-specific progress notes, a physical therapy evaluation, and information from lab results posted on a tri-fold board.~Phase 2 (Simulation): After reviewing the chart and establishing a plan as a group for getting the simulated patient out of bed, the interprofessional team of nursing and physical therapy students will enter the simulated hospital room. The goal for the approximately 20-minute encounter is for the interprofessional group to help the simulated patient to get out of bed while closely monitoring the physiological responses to activity.~Phase 3: The simulation will conclude with a 30-minute faculty guided and structured debriefing session.
Study: NCT04498221

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Imaging procedure
Description: During routine examination under anaesthetic 4 x peritumoural injection of investigator's choice of 99mTc-human albumin colloidal particles or Lymphoseek (lymphatic mapping tracer) followed by freehand SPECT scan

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgical procedure
Description: Excision of contralateral nodes identified on imaging \*(fhSPECT or SPECT/CT\*) during routine examination under anaesthetic. Serial sectioning of excised (sentinel) nodes to identify micrometastasis.
Study: NCT05705024

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Mesenchymal Stromal Cells
Description: Subconjunctival Injection of Allogeneic Mesenchymal Stromal Cellsmasked clinical trial, patients with non-resolving corneal epithelial disease (i.e., refractory to standard treatments for at least two weeks) will receive a single subconjunctival injection of bone marrow-derived allogeneic MSCs or vehicle (CS5 freezing media, BioLife Solutions Inc, Bothell, WA, USA), with continued follow-up for up to 90 days.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Control Solution
Description: For the control group, 150 µL of injectable normal saline (0.9% NaCl). will be injected.
Study: NCT04765371

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: DEXAMETHASONE
Description: Patients will take 60 mg per day of Prednisolone (40 mg morning and 20 md evening) between D1 to D10

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: PREDNISOLONE
Description: Patients will take 60 mg per day of Prednisolone (40 mg morning and 20 md evening) between D1 to D10
Study: NCT06509659

Intervention type: DIAGNOSTIC_TEST
Intervention: Methacholine Challenge Test
Description: MCT with IOS alone versus MCT IOS and FEV1 combined
Study: NCT06190093

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: bevacizumab
Description: 1.25 mg, intravitreal injection

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: ranibizumab
Description: 0.5mg, intravitreal injection
Study: NCT05992935

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1403
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1405
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1405
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1405
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1405
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: mRNA-1405
Description: Sterile liquid for injection

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% sodium chloride (normal saline) injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 0.9% sodium chloride (normal saline) injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 0.9% sodium chloride (normal saline) injection

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% sodium chloride (normal saline) injection
Study: NCT04576507

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cannabis
Description: Investigates two strengths of cannabis.
Study: NCT06539598

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Respiratory Strength Training (RST)
Description: Respiratory Strength training involves inhaling/exhaling against a fix resistant to potentially increase respiratory strength
Study: NCT06289751

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cadonilimab
Description: 10 mg/kg (body weight), 60 min, IV. Repeat every 3 weeks for a total of 3 cycles

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel-albumin
Description: 260 mg/m2 for 30 min. Repeat every 3 weeks for a total of 3 cycles.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: 75-80 mg/m2, IV, 1 mg/min. Repeat every 3 weeks for a total of 3 cycles.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Extrafascial hysterectomy
Description: Extrafascial hysterectomy + pelvic lymphadenectomy (or SLN mapping) (For participants who meet ConCerv criteria)

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radical hysterectomy
Description: Radical hysterectomy + pelvic lymphadenectomy ± para-aortic lymphadenectomy (or SLN mapping) (For participants who do not meet ConCerv criteria)

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cone biopsy
Description: Cold knife conization (CKC) (For participants with tumor size ≤2 cm after 3 cycles of chemo-immunotherapy)
Study: NCT06582433

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention
Description: 1. Process: implementation of pre-tests~2. Process: Solution-focused counseling, 60 minutes once a week for a total of 6 sessions~3. Final test after 2 months
Study: NCT06175767

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MT101-5
Description: Tablet

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MT101-5
Description: Tablet

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MT101-5
Description: Tablet
Study: NCT05011942

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Irrisept Irrigation solution
Description: ii. Irrigation (Irrisept vs control of normal saline) used after initial skin inicision prior to coming through fascia, after placement of instrumentation (screws, hooks), prior to placement of bone graft, and after fascial closure iii. Irrigation exposure/soak time to be 1 min for each irrigation time point. iv. 1 bottle (450 mL) Irrisept irrigation to be used during case with normal saline rinse to follow at each irrigation time point in study subjects v. Normal saline irrigation will be used alone in control subjects at the same time points.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Irrisept Irrigation solution
Description: ii. Irrigation (Irrisept vs control of normal saline) used after initial skin inicision prior to coming through fascia, after placement of instrumentation (screws, hooks), prior to placement of bone graft, and after fascial closure iii. Irrigation exposure/soak time to be 1 min for each irrigation time point. iv. 1 bottle (450 mL) Irrisept irrigation to be used during case with normal saline rinse to follow at each irrigation time point in study subjects v. Normal saline irrigation will be used alone in control subjects at the same time points.
Study: NCT05748873

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SPVN06
Description: AAV-RdCVF-RdCVFL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SPVN06
Description: AAV-RdCVF-RdCVFL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SPVN06
Description: AAV-RdCVF-RdCVFL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SPVN06
Description: AAV-RdCVF-RdCVFL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SPVN06
Description: AAV-RdCVF-RdCVFL
Study: NCT05512403

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PET/CT with 18F-DOPA
Description: A 18F-FDOPA PET exam is then performed (acquisition of 30 minutes in List Mode format) according to the French guidelines for PET neuro-oncological indications (Verger et al. Med Nuc, 2020, (5)).~Patient preparation and acquisition:~* 4 hours of fasting~* No carbidopa premedication~* 2 MBq / kg of 18F-FDOPA~* Dynamic acquisition in List Mode format for 30 min starting simultaneously with the patient's injection~* Low dose scanner for attenuation correction
Study: NCT04885569

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motivational interviewing with CBT (MICBT)
Description: The culturally adapted MICBT will include approaches of motivational interviewing and offer ways of managing difficulties from a cognitive behavioural formulation.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness based Relapse Prevention (MBRP)
Description: MBRP will incorporate cognitive-behavioural skills (i.e., effective coping skills, self-efficacy, and recognizing common antecedents of relapse) with mindfulness-based practices to decrease the probability of relapse by increasing awareness and flexible responding in the presence of substance use triggers.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CAMIAB
Description: This will be integrated CBT based motivational interviewing plus mindfulness based relapse prevention intervention group.
Study: NCT05334732

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SIS TALK Back Intervention
Description: The participants in this arm will be seen by a trained survivor coach and receive culturally tailored intervention materials.
Study: NCT06199635

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Self-Forming Magnetic Anastomosis Device and Delivery System
Description: Self-Forming Magnetic Anastomosis Device to create a gastrointestinal anastomosis

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Self-Forming Magnetic Anastomosis Device and Delivery System
Description: Self-Forming Magnetic Anastomosis Device to create a gastrointestinal anastomosis

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Self-Forming Magnetic Anastomosis Device and Delivery System
Description: Self-Forming Magnetic Anastomosis Device to create a gastrointestinal anastomosis
Study: NCT04982562

Intervention type: OTHER
Group type: OTHER
Intervention: 7T MRI
Description: Seven tesla brain MRI (7T MRI) at day 7 in patients suffering from post concussionnal symptoms after mild traumatic brain injury admitted to emergency departement of Poitiers CHU (University Hospital
Study: NCT05856500

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: basic nutrition
Description: An adequate supply of energy and protein in diet, oral nutrition supplement or tube feeding enteral nutrition supplement when diet is deficient.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: oral supplement of creatine and curcumin
Description: Creatine and curcumin are orally added other than basic nutrition treatment.
Study: NCT05623332

Intervention type: DIAGNOSTIC_TEST
Intervention: Maraciclatide
Description: Imaging marker that binds to AVB3/5 lesions
Study: NCT04424537

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Control diet
Description: Meal replacement beverages made with whey protein

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Low branched-chain amino acids(BCAA) diet
Description: meal replacement beverages (MRBs) made with BCAD2 powder (lacking BCAAs).

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Low protein diet
Description: meal replacement beverages(MRBs) containing low protein
Study: NCT05856877

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Human nasal insulin
Description: single dose of 160 U of human insulin as nasal spray

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Single dose of placebo solution as nasal spray
Study: NCT05777408

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Physical Therapy
Description: * 15 mins of TENS (frequency 100 Hz, phase duration 50 μs) with moist heat over the area of pain~* Isomeric Stretching of neck muscles followed by neck isometrics

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Conventional Physical Therapy
Description: * 15 mins of TENS (frequency 100 Hz, phase duration 50 μs) with moist heat over the area of pain~* Isomeric Stretching of neck muscles followed by neck isometrics

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Natural Apophyseal glides
Description: -Will be applied in sitting position Therapist right hand would cradle the head such that the little finger would rest on the spinous process of the vertebra that is to be mobilized. The other hands thumb would be used to apply over pressure. Direction of force will be parallel to highly irritable-grossly restricted cervical facet joints. Intervention would involve 3 sets of 20 repetitions in 15minutes, 3 days a week for 2 weeks comprising of total 6 session.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Natural Apophyseal glides
Description: -Will be applied in sitting position Therapist right hand would cradle the head such that the little finger would rest on the spinous process of the vertebra that is to be mobilized. The other hands thumb would be used to apply over pressure. Direction of force will be parallel to highly irritable-grossly restricted cervical facet joints. Intervention would involve 3 sets of 20 repetitions in 15minutes, 3 days a week for 2 weeks comprising of total 6 session.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cranial Base Release
Description: Will be performed in lying position. therapist fingers will contact the sub occipital muscles and upward pressure would be given until the tissues and muscles relax. it will be given once daily for 3 days a week and will continue for 2 weeks
Study: NCT05858086

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Novel same-day discharge protocol after total joint arthroplasty
Description: Preoperative gait/stair training with physical therapy, then postoperative ambulation with nursing after total joint arthroplasty

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional postoperative physical therapy clearance
Description: Physical therapy evaluation and clearance after total joint arthroplasty