TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05664451

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: UI-Assist
Description: To support primary care in implementing guideline-based care, it is helpful to distill interventions to their key components, such as the five major intervention steps for tobacco use and dependence (the 5 A's). The 5 A's (Ask, Advise, Assess, Assist, Arrange) has been shown to help primary care providers implement clinical practice guidelines with minimal additional burden. The 5 A's can be similarly simplified for urinary incontinence (UI) screening and treatment to Ask (screen for UI); Advise (inform that effective nonsurgical treatments exist); and Assist (help patient get treatment with pharmacotherapy, referral to community classes, physiotherapy or urology / urogynecology).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: UI-Assist
Description: To support primary care in implementing guideline-based care, it is helpful to distill interventions to their key components, such as the five major intervention steps for tobacco use and dependence (the 5 A's). The 5 A's (Ask, Advise, Assess, Assist, Arrange) has been shown to help primary care providers implement clinical practice guidelines with minimal additional burden. The 5 A's can be similarly simplified for urinary incontinence (UI) screening and treatment to Ask (screen for UI); Advise (inform that effective nonsurgical treatments exist); and Assist (help patient get treatment with pharmacotherapy, referral to community classes, physiotherapy or urology / urogynecology).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Partnership Building
Description: In addition to the strategies described above, those practices allocated to streamlined practice facilitation and partnership building will have facilitation and configurable solutions that engage community resources and enable coalition building. In addition to a practice facilitator, a partnership facilitator from the Wisconsin Institute for Healthy Aging (WIHA) will identify existing local community resources with which the practice may choose to partner. After initiating academic detailing, these practices will have further access to Drs. Brown and Neuner for ongoing consultation. An online learning community will also be created where information can be shared and exchanged throughout the duration of the project and beyond the maintenance phase.
Study: NCT05632757

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Psychological assessments
Description: The visit will take place during a multidisciplinary assessment in the ALS Center at the Timone Hospital, Neuromuscular Disease and ALS Department. The patient will be accompanied by his/her caregiver. During this multidisciplinary assessment, the patient is present at the hospital between 8am and 4pm. The various scales and self-questionnaires can be completed during this time. The time required to complete these scales and self-questionnaires is estimated to be about 90 minutes.
Study: NCT05053750

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel/Bev (control)
Description: Given by PO
Study: NCT04968548

Intervention type: PROCEDURE
Intervention: Blood collection
Description: Peripheral blood will be collected via routine venipuncture procedure

Intervention type: PROCEDURE
Intervention: Blood collection
Description: Peripheral blood will be collected via routine venipuncture procedure
Study: NCT06118476

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: 3D animation
Description: Education with 3D animation videos
Study: NCT04504968

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multimodal intervention
Description: 1. Optimal control: HbA1c between 7.6-8.5% (60-69 mmol/mol) and Blood Pressure\<150/90 mmHg~2. The physical exercise program that will be used will be the Vivifrail program (Erasmus + UE). Vivifrail includes: Strength for arms and legs, balance and gait, flexibility and resistance. The duration will be 16 weeks. (3 weeks to explain the program in the Trial site and the rest of weeks, it will be carried out at home).~3. Nutritional and educational program to increase diabetes knowledge, develop practical self-care skills for diabetes and increase the likelihood of improving glycemic control safely. The intervention aims to minimize the risk of hypoglycemia, ensure optimal nutritional status and help to maintain functional status. Seven separate sessions of 45 minutes each one twice a week for a period of 3-4 weeks in small groups. They will be moderated by a physician or diabetes educator and focused on behavioral changes and key points.
Study: NCT05053750

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel/Bev + ZA (experimental)
Description: Given by PO
Study: NCT05027425

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab
Description: 1500 mg IV, Q4W

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tremelimumab
Description: 300 mg IV, 1 dose on day 1 of only the first cycle

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Liver Transplant
Description: minimum 72-day washout from the end of immunotherapy, patients will undergo liver transplant.
Study: NCT05763121

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexpramipexole Dihydrochloride
Description: oral administration of dexpramipexole tablet

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexpramipexole Dihydrochloride
Description: oral administration of dexpramipexole tablet

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: oral administration of placebo tablet
Study: NCT04504968

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Usual care group
Description: The level of usual health care that a patient with diabetes receives from their local national health system
Study: NCT04327544

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Frailty Intervention
Description: In overall, participants will attend one session of frailty talk, 22 sessions of low to moderate intensity of multi-components exercise course and 6 session of nutrition education interventions. Both nutritional education and exercise intervention will be conducted concurrently for a 12-week (3-month) of intervention period. Noted that every session will be held in PPR flats' facility area or hall around 60 minutes that will be conducted by the dietitian or nutritionist and physiotherapist from the research team.
Study: NCT05807295

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Relaxation Program
Description: The relaxation program will include progressive muscle relaxation exercises and videos for relaxation. Videos will be sent to caregivers' social media accounts. Initial applications will be implemented with caregivers. The relaxation program is planned to last 6 weeks. The program is planned to last 8 weeks in total, with pre-test and post-test applications.
Study: NCT06429306

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexycu
Description: 5ul dexamethasone, concentration: 103.4 μg/μl, equivalent to 517μg dexamethasone

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Acetyl triethyl citrate
Study: NCT04327284

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Immediate placement non-occlusal loading molar implant (Straumann BLX 6.5mm)
Description: At the screening visit, potential subjects will be informed about the protocol and all questions related to the study will be answered. Medical and dental histories will be reviewed and physical evaluations will be performed in order to rule out local or systemic factors that would compromise the outcome of the study. A detailed extra and intra oral examination will be performed. Appropriate radiographic imaging studies will be obtained prior to the surgical visit (per the protocol of the University of Kentucky, College of Dentistry) including CBCT and intraoral scans for treatment planning implant through Straumann Guided Surgery workflow.~The duration of the present study is 1 year including the baseline or surgical visit, 2-weeks postoperative visit, 12-weeks baseline for control group and postoperative evaluations at 3, and 12 months.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Delayed placement non-occlusal loading molar implant (Straumann BLX 5.0mm)
Description: At the screening visit, potential subjects will be informed about the protocol and all questions related to the study will be answered. Medical and dental histories will be reviewed and physical evaluations will be performed in order to rule out local or systemic factors that would compromise the outcome of the study. A detailed extra and intra oral examination will be performed. Appropriate radiographic imaging studies will be obtained prior to the surgical visit (per the protocol of the University of Kentucky, College of Dentistry) including CBCT and intraoral scans for treatment planning implant through Straumann Guided Surgery workflow.~The duration of the present study is 1 year including the baseline or surgical visit, 2-weeks postoperative visit, 12-weeks baseline for control group and postoperative evaluations at 3, and 12 months.
Study: NCT05362955

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intravaginal 5-Fluorouracil (5-FU)
Description: Participants will self-administer 2 g of 5% 5-FU intravaginally using an applicator, one night per week (every other week), on weeks 1, 3, 5, 7, 9, 11, 13, 15, for a total of 8 applications.
Study: NCT05437679

Intervention type: OTHER
Intervention: Blood collection
Description: Peripheral blood will be collected from each subject at a single time point and data will be collected from a review of each subject's medical records.

Intervention type: OTHER
Intervention: Blood collection
Description: Peripheral blood will be collected from each subject at a single time point and data will be collected from a review of each subject's medical records.

Intervention type: OTHER
Intervention: Blood collection
Description: Peripheral blood will be collected from each subject at a single time point and data will be collected from a review of each subject's medical records.

Intervention type: OTHER
Intervention: Blood collection
Description: Peripheral blood will be collected from each subject at a single time point and data will be collected from a review of each subject's medical records.
Study: NCT06495268

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Individualised data-driven hearing rehabilitation
Description: HA fittings will be conducted with the Real-Ear Measurements (REM) method that is recommended by the latest ISO-standard (21388:2020) and by the preliminary results of the BREM study at KUH. After the fitting of the HAs, participants' auditory-related outcomes will be immediately assessed using DigiKuulo and re-fitting is performed if needed based on the following criteria:~1. The absolute improvement in the DIN test is less than 1,5dB (SNR), OR~2. The absolute result of the DIN test is more than -8,5 dB (SNR) OR~3. The participant is unsatisfied with the HA fitting~Participants are invited to intervention-related monitoring appointments at 3, 6 and 12 months after the primary HA fitting. At these visits, auditory outcomes of the rehabilitation are assessed via DigiKuulo and re-fittings are performed as needed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard care hearing rehabilitation
Description: HA will be fitted with automatic algorithms by HA manufacturers and REM-fitting is only applied in complex cases based on the hearing rehabilitator's clinical judgement. Three months after the HA fitting, participants will be contacted via phone call to inquire about the status of the rehabilitation. Additional monitoring visits may be offered based on the participant's feedback. After the 3-month monitoring phone call participants will be advised to further contact the study team if they are dissatisfied with the amplification or for any other problem with their device.
Study: NCT06651255

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Optimized management
Description: systematic gastrointestinal and nasal endoscopic exploration, local endoscopic treatment whenever applicable,prophylaxis with stepwise dose escalation of VWF concentrate and use of antiangiogenic drugs in patients with severe GI angiodysplasia-related bleeding

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Standard of care management
Description: Standard of care management
Study: NCT06652048

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Furmonertinib 160mg QD
Description: All patients enrolled into this group will receive furmonertinib 160mg p.o qd.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Furmonertinib 240mg QD
Description: All patients enrolled into this group will receive furmonertinib 240mg p.o qd.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Furmonertinib 160mg QD plus Chemotherapy
Description: All patients enrolled into this group will receive furmonertinib 160mg furmonertinib p.o qd plus chemotherapy\[(carboplatin AUC 5 / cisplatin 75mg/m2+ pemetrexed 500mg/m2) every 21 days ×4 cycles + pemetrexed 500mg/m2 every 21 days maintenance\]
Study: NCT05924555

Intervention type: OTHER
Intervention: Intermittent cardiopulmonary exercise test
Description: Exercise test with step-change from rest to a relatively low constant workload.

Intervention type: OTHER
Intervention: Intermittent cardiopulmonary exercise test
Description: Exercise test with step-change from rest to a relatively low constant workload.

Intervention type: OTHER
Intervention: Incremental cardiopulmonary exercise test
Description: Exercise test with incremental workload until maximal workload.

Intervention type: OTHER
Intervention: Incremental cardiopulmonary exercise test
Description: Exercise test with incremental workload until maximal workload.

Intervention type: OTHER
Intervention: Echography of upper leg
Description: Determine upper leg muscle size

Intervention type: OTHER
Intervention: Echography of upper leg
Description: Determine upper leg muscle size

Intervention type: OTHER
Intervention: Hand grip strength with hand dynamometer
Description: Determine muscle strength

Intervention type: OTHER
Intervention: Hand grip strength with hand dynamometer
Description: Determine muscle strength

Intervention type: OTHER
Intervention: Fill in questionnaires regarding physical activity
Description: SQUASH, mMRC, questionnaire designed to report myopathic symptoms in LcFAOD patients.

Intervention type: OTHER
Intervention: Fill in questionnaires regarding physical activity
Description: SQUASH, mMRC, questionnaire designed to report myopathic symptoms in LcFAOD patients.
Study: NCT05954611

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: GR2002 injection
Description: one single dose of GR2002 injection

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: one single dose of placebo
Study: NCT06567353

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Multi-mode tumor treatment system
Description: All subjects are treated using the multi-mode tumor treatment system (Shanghai MAaGI Medical Technology Co., Ltd), with the treatment procedure conducted according to the temperature control mode for tumor ablation. The treatment procedure includes: rapid freezing of the tumor tissue to form an ice ball extending 5mm beyond the lesion, maintaining this state for 5 minutes, followed by thawing and rewarming; subsequently, RFA is performed to ensure complete ablation, with the ablation zone including a safety margin of 5-10mm around the tumor.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Radiofrequency ablation therapeutic apparatus
Description: All subjects are treated using the radiofrequency ablation therapeutic apparatus (MedSphere International (Shanghai) Co., Ltd.), with the treatment procedure conducted according to the preset power and time parameters to ensure a safety margin of 5-10mm.
Study: NCT04242810

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: rTMS
Description: TMS will be applied over task-based target at an intensity up of 130% rMT. The optimal coil placement during stimulation will be guided using the BrainSight neuronavigation system.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Sham rTMS
Description: An electrical sham coil that produces the same auditory and somatosensory stimulations, without a significant magnetic field, will be used as an active control.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: MRI scan
Description: Participants will undergo an MRI scan directly after rTMS stimulation that will last less than 120 minutes. During the scan, subjects will encode and retrieve object pictures.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: MRI scan
Description: Participants will undergo an MRI scan directly after rTMS stimulation that will last less than 120 minutes. During the scan, subjects will encode and retrieve object pictures.
Study: NCT06144138

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Breathing Exercises followed by Meditation
Description: Breathing exercises and Meditation taught by Prasanna Wellness, a non-profit organization, helps dissolve stress and create a proper system in the mind. These breathing exercises include slow deep breaths and rapid breaths and are followed by meditation. Meditation is a guided meditation that helps to eliminate stress and establish an apposite system in the mind, therefore inducing physiological and mental relaxation whilst the eyes are shut. The proposed duration and frequency of the follow-up will be 60-minutes weekly for 11 weeks.
Study: NCT05712499

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: mindfulness-based psychoeducation program
Description: Mindful awareness is a mind and body practice that involves increasing attention to what is happening at the moment and accepting what is perceived without judgment. Mindfulness includes awareness and attention; Awareness is the mechanism that constantly controls the of the state of consciousness. Mindfulness-based cognitive therapies are evidence-based psychoeducation. Psychoeducation was organized in 2 consecutive sessions once a week for 8 weeks, and each session was 60 minutes, in total 16 sessions. The content of the psychoeducation program was explained in detail, and techniques such as presentation and question-answer narrative techniques, video, audio recording, mindfulness assignments for the next session were used in the training.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: ongoing life
Description: The control group continued with their lives without any intervention. Only pre-test and post-test were applied. While the program was applied to the experimental group, no intervention was made to the control group.
Study: NCT04297254

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenvatinib
Description: Lenvatinib capsules.
Study: NCT06346093

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Fecal Microbiota Transplantation Capsules
Description: FMT Capsules in Combination with Chemotherapy and Anti-PD-L1 Therapy

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Mainly composed of starch, the appearance, shape, color, and size are exactly the same as FMT capsules
Study: NCT06567990

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Non-invasive test for the screening of MASLD-related advanced fibrosis in patients with T2D.
Description: * Non-invasive blood biological tests = NAFLD Fibrosis Score, FIB-4 score, FNI score, Agile3+ score, FASTscore, ELF, Fibrotest, Fibrometer if performed in clinical care~* Non-invasive imaging = Transient elastography (FibroScan), Questionnaire assessing alcohol consumption

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Non-invasive test for the screening of MASLD-related advanced fibrosis in patients with T2D.
Description: * Non-invasive blood biological tests = NAFLD Fibrosis Score, FIB-4 score, FNI score, Agile3+ score, FASTscore, ELF, Fibrotest, Fibrometer if performed in clinical care~* Non-invasive imaging = Transient elastography (FibroScan), Questionnaire assessing alcohol consumption
Study: NCT06652230

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Smile Arc Marginal Ridge Approach (SAMRA)
Description: Smile Arc Marginal Ridge Approach (SAMRA) is a new orthodontic bonding technique proposed by Dr. Dalia El Bokle where she stated that it provides more accurate orthodontic results and less time and effort needed during finished. No randomized clinical trials are done on this new approach yet so our study is the first one to test it. 0.018-inch MBT brackets will be used in our study.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: MBT Chart Method
Description: For our comparator group MBT Chart Method will be used. Using charts during orthodontic bonding procedures is considered the gold standard. 0.018-inch brackets will be used.
Study: NCT06653270

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Virtual reality simulator
Description: A in-house developed immersive virtual simulation of a normal vaginal delivery developed using a Unity Engine and installed in Oculus® Quest 2 head-mounted device

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Mannequin-based simulator
Description: Legacy PROMPT Flex® mannequin
Study: NCT06147882

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: The group will include patients with fibromyalgia syndrome who will receive positive psychotherapy.
Description: The group will include patients with fibromyalgia syndrome who will receive positive psychotherapy.
Study: NCT06652659

Intervention type: OTHER
Intervention: Non-union
Description: Observational study looking prospectively at many different factors that may affect non-union of midshaft clavicle fractures.
Study: NCT06604949

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LP-003 200mg
Description: Subcutaneous injection of 200 mg LP-003

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subcutaneous injection of placebo
Study: NCT06212375

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Vegetable variety
Description: Either children are offered a variety of three vegetables or a single vegetable.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Vegetable offering strategy
Description: Either children can decide when to eat their vegetables or parents initiate a moment.