TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05818033

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CARE1.02
Description: Participants in the intervention group will wear CARE1.02 and receive the follow-up checks.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Single-vision spectacle lens
Description: Participants in the control group will wear single-vision spectacle lens and receive the follow-up checks.
Study: NCT06480968

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CTH120
Description: FIH-CTH120-SAD: Each independent cohort of 8 subjects (placebo=2 and CTH120=6 per dose) will receive a single administration of CTH120 or placebo. Four consecutive dose levels (20 mg/day, 40 mg/day, 85 mg/day and 160 mg/day) are planned. If no significant clinical adverse events are observed in the FIH-CTH120-SAD phase, an additional 5th cohort will be recruited to conduct the 5th dose level.~FIH-CTH120-MAD: Each independent cohort of 8 subjects (placebo=2 and CTH120=6 per dose) will receive a daily administration of CTH120 or placebo for 7 days. Three consecutive dose levels are planned. The starting dose will be confirmed following the observed results of FIH-CTH120-SAD.~FIH-CTH120-FI: One dosage of CTH120 will be assessed in 12 healthy male and female subjects in two conditions (Fed and Fasting). Subjects will be randomly assigned to 2 sequences: 6 subjects in a sequence fed then fasting condition, 6 subjects in the reverse sequence (fasting, then fed condition).

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: FIH-CTH120-SAD: Each independent cohort of 8 subjects (placebo=2 and CTH120=6 per dose) will receive a single administration of CTH120 or placebo. Four consecutive dose levels (20 mg/day, 40 mg/day, 85 mg/day and 160 mg/day) are planned. If no significant clinical adverse events are observed in the FIH-CTH120-SAD phase, an additional 5th cohort will be recruited to conduct the 5th dose level.~FIH-CTH120-MAD: Each independent cohort of 8 subjects (placebo=2 and CTH120=6 per dose) will receive a daily administration of CTH120 or placebo for 7 days. Three consecutive dose levels are planned. The starting dose will be confirmed following the observed results of FIH-CTH120-SAD.
Study: NCT06492590

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Multicomponent intervention
Description: Multicomponent intervention based on psycho-education and physical rehabilitation.
Study: NCT05000645

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Grocery delivery
Description: Each food delivery will contain approximately $35 worth of fresh fruits, vegetables, dairy products, and whole grain foods. These foods are not meant to supplant regular meals, rather make healthy eating more convenient.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Grocery delivery
Description: Each food delivery will contain approximately $35 worth of fresh fruits, vegetables, dairy products, and whole grain foods. These foods are not meant to supplant regular meals, rather make healthy eating more convenient.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Unsweetened beverage delivery
Description: Participants will receive unsweetened beverages to replace normal sugar-sweetened beverage intake.
Study: NCT05028062

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: XR-NTX 380 mg, intramuscular injection
Description: Two doses of XR-NTX 380 mg, intramuscular injection.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Medical Management
Description: All subjects will receive 8 weeks of medical management (Pettinati et al. 2004) will support subjects' efforts to reduce or stop their drinking. The study nurse makes direct recommendations for reducing drinking to sensible levels. The first session will use the brochure A Guide to Sensible Drinking (WHO 1996). Subsequent treatment sessions (15-25 minutes) will be conducted at each study visit, during which the nurse will perform an assessment of the subject's drinking, and make recommendations to follow until the next visit. Men will be advised to consume no more than 3 drinks 4 times per week; women will be advised to consume no more than 2 drinks 4 times per week.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Medical Management
Description: All subjects will receive 8 weeks of medical management (Pettinati et al. 2004) will support subjects' efforts to reduce or stop their drinking. The study nurse makes direct recommendations for reducing drinking to sensible levels. The first session will use the brochure A Guide to Sensible Drinking (WHO 1996). Subsequent treatment sessions (15-25 minutes) will be conducted at each study visit, during which the nurse will perform an assessment of the subject's drinking, and make recommendations to follow until the next visit. Men will be advised to consume no more than 3 drinks 4 times per week; women will be advised to consume no more than 2 drinks 4 times per week.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo intramuscular injection
Description: Two doses of XR-NTX 380 mg, intramuscular injection.
Study: NCT06252753

Intervention type: OTHER
Intervention: Durvalumab-based combination therapies in observational study setting
Description: Data on patients who initiated durvalumab-based regimens, including STRIDE (Single Tremelimumab Regular Interval Durvalumab), will be collected).

Intervention type: OTHER
Intervention: Durvalumab-based combination therapies in observational study setting
Description: Data on patients who initiated durvalumab-based regimens, including durvalumab + chemotherapy combinations (e.g., Durvalumab + GemCis etc.) will be collected.
Study: NCT06313528

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3437943
Description: Administered SC
Study: NCT06727526

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupressure
Description: The literature found that acupressure positively affects child health, but no study was found to determine the effect of acupressure on pain and physiological parameters in children undergoing cardiac catheterization. Therefore, this study was designed to determine the effect of acupressure applied before and after cardiac catheterization on infants' pain levels and physiological parameters.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo acupressure
Description: In health sciences, placebo refers to an inactive intervention used to relax the patient and assess treatment efficacy. It may involve inert substances (e.g., sugar tablets, saline) or non-therapeutic interventions (e.g., artificial electrical stimulation or conversations). Expectancy theory often explains The placebo effect, which suggests that treatment expectations can induce physiological changes. Factors like age, cognitive development, and previous pain experiences influence children's responses to placebo. Parental belief in an intervention's efficacy can reduce a child's pain expectations and positively influence their perception of pain. Although the sample included young children, our study incorporated the placebo group to account for this effect, especially since the parents evaluated pain scores.
Study: NCT06728332

Intervention type: OTHER
Intervention: No study intervention
Description: No visits or examinations, laboratory tests or procedures are mandated or required for this study. Providers in the study recruitment network will recruit eligible patients through an existing visit. After this referral, the study is conducted entirely electronically.
Study: NCT06735859

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Comparison of eating windows intervention
Description: Participants will be randomized into two groups to follow either eating window for 12 months, with normocaloric meal plans based on the Mediterranean diet adapted to Brazilian culture. After 12 months, a 3-month washout period will follow, during which participants return to their usual eating patterns. The groups will then be swapped to follow the opposite eating window for another 12 months. Finally, a new data collection will be conducted 3 months post-intervention to analyze the stability of behavior.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Comparison of eating windows intervention
Description: Participants will be randomized into two groups to follow either eating window for 12 months, with normocaloric meal plans based on the Mediterranean diet adapted to Brazilian culture. After 12 months, a 3-month washout period will follow, during which participants return to their usual eating patterns. The groups will then be swapped to follow the opposite eating window for another 12 months. Finally, a new data collection will be conducted 3 months post-intervention to analyze the stability of behavior.
Study: NCT06738784

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Perceive, Recall, Plan and Perform (PRPP) evaluation
Description: Passing the PRPP for 2 activities
Study: NCT05659732

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PEP07
Description: PEP07 is a selective Chk1 inhibitor maleate drug which is supplied as a hard gelatin capsule. PEP07 will be provided as 20 mg and 150 mg strength capsules to be administrated orally. Patients allocated to different dose levels of PEP07 monotherapy will receive either 20 mg or 150 mg oral capsules for 2 consecutive days followed by 5 days treatment off (2-on/5-off) schedule every week, 4 weeks as a treatment cycle.
Study: NCT04740229

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Yoga
Description: Moderate-intensity flow-based yoga movements, breathing, and relaxation for 50 minutes, 3 times per week, for 8 weeks
Study: NCT05510830

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: diagnostic cervical conization
Description: For the patients who met the inclusion criteria, the gynecologists perform cervical conization and pathological examinations. Then the patients will be followed-up for at least two years with the tests of cervical TCT \& HPV, and colposcopy if necessary. The data will be analyzed and see if the patients with high risk factors benefit from the surgery or not.
Study: NCT05022381

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Radiofrequency thermal coagulation of articular branches of femoral and obturator nerves
Description: Patients are operated under sedation in the operating room. C-arm fluoroscopy device is used for imaging purposes for radiofrequency thermocoagulation process. In order to prevent vascular injury, the needle is advanced under the guidance of ultrasonography. There are target points determined in fluoroscopy for the femoral nerve and the obturatory nerve. Before the thermocoagulation procedure, local anesthetic and steroid are injected into each of the target points. Patients who do not have any complications after the procedure and who are mobilized are discharged in the 2nd hour.
Study: NCT06559722

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Insulin Degludec/liraglutide Injection
Description: Subcutaneously (s.c., under the skin)administration once daily in combination with metformin. Dose was individually adjusted.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: XULTOPHY®
Description: Subcutaneously (s.c., under the skin)administration once daily in combination with metformin. Dose was individually adjusted.
Study: NCT05995470

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Internet-based dialectical behaviour therapy-informed skills training
Description: Adaptive applications of DBT-ST for drinkers with psychological distress

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Monthly health education
Description: General health information and sharing sessions
Study: NCT04788823

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Treatment groups will be administered different dosages of Prednisone post vasectomy reversal.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Treatment groups will be administered different dosages of Prednisone post vasectomy reversal.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Treatment groups will be administered different dosages of Prednisone post vasectomy reversal.
Study: NCT06741267

Intervention type: DEVICE
Group type: OTHER
Intervention: RBS
Description: physicians control RBS
Study: NCT06167161

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Hearing aid
Description: The hearing aid is a receiver-in-canal style hearing aid which can be programmed and adjusted by proprietary software and through a dedicated smartphone application

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Hearing aid
Description: The hearing aid is a receiver-in-canal style hearing aid which can be programmed and adjusted by proprietary software and through a dedicated smartphone application
Study: NCT06741267

Intervention type: DEVICE
Group type: OTHER
Intervention: AB
Description: physician control automatic bronchoscopy

Intervention type: DEVICE
Group type: OTHER
Intervention: ENB
Description: physicians control electromagnetic bronchoscopy
Study: NCT00012610

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Telepsychiatry
Study: NCT05695547

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: VR educational video
Description: Patients will be educated with our specifically made VR video in the settings of our hospital to make patients more familliar with the spaces and to explain them the procedure.
Study: NCT06740344

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Two-handed facemask hold
Description: Two-handed mask hold technique while giving facemask ventilation, with another operator designated to deliver PIP via the T-piece.
Study: NCT05162911

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Ask, advise, Assist and refer to the Quitline
Description: A nurse will ask, advise, assist and refer patient to the Quitline

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Ask, advise, Assist and referral to onsite counselor
Description: A nurse will ask, advise, assist and refer patient to a counselor

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Ask, advise, Assist and referral to onsite counselor and NRT
Description: A nurse will ask, advise, assist and refer patient to a counselor and provide nicotine replacement therapy in the form of gum
Study: NCT06740344

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Control: One-handed facemask hold
Description: One-handed mask hold technique while giving facemask ventilation, with the same operator holding the mask and delivering PPV via the T-piece.
Study: NCT06449248

Intervention type: OTHER
Intervention: Checking of appropriateness of OLP diagnosis
Description: The above mentioned interventions will be carried out through the accurate analysis of patients' clinical records
Study: NCT05469308

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: questionary
Description: When the patients renew their treatment in community pharmacy, they have an adherence record with a pharmacist who calculates the PDC score, and perform questionaries on adherence to the DOACs, and collects data about clinical history and pharmacological information on the prescribed DAOCs, demography.
Study: NCT06736873

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Light intervention
Description: Light intervention
Study: NCT06319443

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Liquid vinegar
Description: 3.5 g acetic acid

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: vinegar pill
Description: 0.022 g acetic acid
Study: NCT04898465

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Social Paediatric Intervention
Description: Family will meet the hospital's social-paediatrician and social worker. Together they will evaluate the need for social support, risk for neglect and refer families for local social services if needed. The visit will contain primary and secondary prophylaxis of child abuse and neglect.
Study: NCT06736873

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Light intervention
Description: Light intervention
Study: NCT06734962

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Apical surgery procedure using A-PRF
Description: Participants will undergo an apical surgery procedure using A-PRF. Before the surgery and at follow-ups, patients will undergo comprehensive evaluation using clinical, radiological, and ultrasonographic techniques.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Apical surgery without using A-PRF
Description: Participants will undergo an apical surgery procedure without using A-PRF. Patients will undergo comprehensive evaluation before the surgery and at follow-ups using clinical, radiological, and ultrasonographic techniques.
Study: NCT06373939

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Digital lung auscultation
Description: Two 30-second recordings will be made using CE-marked Littmann® CORE digital stethoscopes and the Pneumoscope at two bilateral lung positions on the posterior chest wall, focusing on the lower lobes. Spectral comparison and audio quality indices will be assessed between the Pneumoscope and the Littmann® CORE digital stethoscope.~Comparator: The Gold Standard Littmann® CORE picks up sounds, such as heart and lung sounds, from a patient's body. After amplification and filtering, the sounds are sent to the user through a binaural headset. The stethoscope chest piece is designed for use with adult, pediatric, and infant patients.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Pulse oximetry measurement
Description: Pulse oximetry and heart rate will be measured using the CE-marked Masimo Rad-G® and iHealth® Air oximeters, as well as the Pneumoscope's built-in oximeter. Agreement between the Pneumoscope's oximeter and the reference oximeters will be evaluated. Measurement will take 30 second on the right index finger.~Comparators:~1. The Gold Standard Masimo Rad-G® sensor is indicated for the continuous noninvasive peripheral monitoring of arterial oxygen saturation (SpO2) and pulse rate. Its use consists in positioning the emitting window of the sensor attachment envelope on the top of the finger nail bed, while the detector is placed opposite the emitter on the other side of the same finger.~2. The Gold Standard iHealth® Air works by projecting two beams of light through a clip with a transmitter and a detector that is placed around a finger, nail side down and screen side up.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Non invasive body temperature measurement
Description: Comparison of body temperature measurements between the Pneumoscope's built-in thermometer and Gold Standard thermometers (Terumo® C205 and VisioFocus Pro 06480).~Comparators:~1. The Gold Standard Terumo® C205 is an axillary thermometer. Its use consists in placing the probe in the armpit, then lowering the arm and holding the device firmly until the temperature is stabilised and the temperature is read and displayed on the thermometer screen.~2. The Gold Standard VisioFocus Pro 06480 is an infrared thermometer that detects the infrared radiation naturally emitted by the body and in particular from the human forehead. Its use consists in holding the thermometer close to the forehead but without direct contact with the skin. The temperature reading is then projected on the patient's forehead using a symbol system.
Study: NCT04740190

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Talazoparib
Description: low dose whole brain radiation, followed by combination talazoparib and carboplatin
Study: NCT06740084

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Y-MIND Intervention
Description: All participants in the intervention arm will receive the EUC plus the Y-Mind intervention. Y-Mind intervention will be delivered by trained and supervised Guidance and Counselling Coordinators (GCC) at schools in 6 sessions. The six sessions will include a) psychoeducation on depression, b) behavioural activation (helping the participant see the connection between their behaviour, daily activities, and low mood and activity scheduling) and c) problem-solving therapy (the GCC helps the participant identify and define a specific problem to work on, evaluate the potential solutions to the problem, and carry out the selected solution(s)).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Enhanced Usual Care
Description: Enhanced Usual Care (EUC): Guidance and counselling coordinators in the schools provide some counselling to students who need it. Building on the existing structure, enhanced usual care in the Y-mind programme, will be enhanced in three ways: 1) Teaching staff will receive basic training on common mental health conditions affecting youth in Ghana with an emphasis on depression and suicidal symptoms and treatment. The WHO guidelines for school health services will form the basis for the training for teachers. 2) Nurses in all schools and other relevant local health care professionals will be trained in mental health, substance-use and self-harm including guidelines on when and where to refer young people for psychiatric care. The World Health Organization (WHO) Mental Health Gap intervention guide (mhGAP) will be used for training of nurses and other health care professionals . 3) The study team will provide a letter for the Guidance and Counselling Coordinators for the participant.
Study: NCT06738147

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pelvic floor muscle training
Description: pelvic floor muscle training (PFMT) for 30 min., 3 sessions/ week in addition to traditional physical and balance training program (proprioception training and balance exercises for the static and dynamic components of balance for 30 min., three sessions/ week for six weeks.

Intervention type: OTHER
Group type: OTHER
Intervention: balance exercises
Description: traditional physical and balance training program (proprioception training and balance exercises for the static and dynamic components of balance for 30 min., three sessions/ week for six weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: balance exercises
Description: traditional physical and balance training program (proprioception training and balance exercises for the static and dynamic components of balance for 30 min., three sessions/ week for six weeks.
Study: NCT06738082

Intervention type: BIOLOGICAL
Intervention: Influenza vaccine
Description: Standard, commercially available, quadrivalent split-vaccine against influenza is given to all study participants.

Intervention type: BIOLOGICAL
Intervention: Influenza vaccine
Description: Standard, commercially available, quadrivalent split-vaccine against influenza is given to all study participants.

Intervention type: BIOLOGICAL
Intervention: Influenza vaccine
Description: Standard, commercially available, quadrivalent split-vaccine against influenza is given to all study participants.

Intervention type: BIOLOGICAL
Intervention: Influenza vaccine
Description: Standard, commercially available, quadrivalent split-vaccine against influenza is given to all study participants.

Intervention type: BIOLOGICAL
Intervention: Influenza vaccine
Description: Standard, commercially available, quadrivalent split-vaccine against influenza is given to all study participants.