Study: NCT05969795

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Transvaginal ultrasound
Description: Intermittent transvaginal ultrasound throughout the cycle to monitor follicular growth

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Transvaginal ultrasound
Description: Intermittent transvaginal ultrasound throughout the cycle to monitor follicular growth

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serial serum LH, E2, P4
Description: Serial measurements of serum Luteinizing Hormone (LH), Estradiol (E2) and Progesterone (P4 )levels throughout the cycle to determine ovulation. LH-surge is identified when a rise of 180% above the previous level occurred and ovulation is confirmed with a decrease in E2 concentration, and a rise of progesterone level to ≥ 1.0 ng/ml (Irani et al., 2017).

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serial serum LH, E2, P4
Description: Serial measurements of serum Luteinizing Hormone (LH), Estradiol (E2) and Progesterone (P4 )levels throughout the cycle to determine ovulation. LH-surge is identified when a rise of 180% above the previous level occurred and ovulation is confirmed with a decrease in E2 concentration, and a rise of progesterone level to ≥ 1.0 ng/ml (Irani et al., 2017).

Intervention type: DRUG
Group type: OTHER
Intervention: Progesterone 100 Mg Vaginal Insert
Description: On day of ET procedure, to administer 200 mg of vaginal progesterone and increase to 300 mg/day from the day after the ET onwards until the pregnancy test. In case of an implantation, vaginal P4 will be continued until 7 weeks of pregnancy

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum P4 day of ET - Control Group
Description: Serum P4 will be drawn before starting LPS in form of vaginal progesterone on the day of ET procedure

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum P4 day of ET - Study Group
Description: Serum P4 will be drawn when study group participants are admitted to the clinic for the ET procedure.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Embryo transfer
Description: The procedure in which embryo is placed in the uterus.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Embryo transfer
Description: The procedure in which embryo is placed in the uterus.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum hCG 10 days after ET
Description: Pregnancy will be confirmed / excluded by measurement of serum hCG 10 days after ET procedure and a level of \> 15 IU will be regarded as positive result. The definitions of biochemical, ectopic, clinical and ongoing pregnancy follow the ICMART criteria (Zegers-Hochschild, 2006)

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum hCG 10 days after ET
Description: Pregnancy will be confirmed / excluded by measurement of serum hCG 10 days after ET procedure and a level of \> 15 IU will be regarded as positive result. The definitions of biochemical, ectopic, clinical and ongoing pregnancy follow the ICMART criteria (Zegers-Hochschild, 2006)

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum P4 10 days after ET
Description: Serum P4 will be drawn on day 5 or day 6 after the ET procedure and together with the hCG 10 days after ET procedure

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum P4 10 days after ET
Description: Serum P4 will be drawn on day 5 or day 6 after the ET procedure and together with the hCG 10 days after ET procedure