TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05165212

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amoxicillin
Description: Patients will be given 10% of a standard weight-based dose of amoxicillin and observed for signs/symptoms of allergic reaction for 30 minutes. If no reaction occurs, they will given the remaining 90% of the standard dose and observed for an additional 30 minutes.
Study: NCT05834517

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hyaluronic acid
Description: Hyaluronic Acid (HA) is an addition to the local chemotherapeutic agents. Hyaluronic acid was discovered by Meyer and Palmer. HA is widely found in the extracellular matrix and it plays an essential role in controlling cell behavior including random motility, metabolic reactions, chemotaxis, proliferation and invasion. HA is released by many cells including fibroblasts
Study: NCT05396196

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Kinesio® Tape
Description: Manual Fascial Glide Application

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Kinesio® Tape
Description: Manual Fascial Glide Application
Study: NCT05834517

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: non surgical periodontal therapy
Description: NSPT, with or without adjunctive therapies, is an effective treatment for periodontitis. It reduces PD and results in formation of some new attachment; however, it also has several limitations, and surgical therapy might be required to control inflammation and optimize outcomes. When used for non-surgical scaling and root planing, periodontal curettes can reach a mean PD of up to approximately 5.5 mm. The mean PD in which a plaque-free and calculus-free surface can be established is \<4 mm

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: non surgical periodontal therapy
Description: NSPT, with or without adjunctive therapies, is an effective treatment for periodontitis. It reduces PD and results in formation of some new attachment; however, it also has several limitations, and surgical therapy might be required to control inflammation and optimize outcomes. When used for non-surgical scaling and root planing, periodontal curettes can reach a mean PD of up to approximately 5.5 mm. The mean PD in which a plaque-free and calculus-free surface can be established is \<4 mm
Study: NCT05584553

Intervention type: DEVICE
Intervention: ToggleLoc 2.9 mm soft tissue device
Description: The ToggleLoc 2.9 mm Soft Tissue devices consist of non-resorbable devices intended to aid in arthroscopic and orthopaedic reconstructive procedures requiring soft tissue to bone fixation.

Intervention type: DEVICE
Intervention: JuggerLoc soft tissue device
Description: The JuggerLoc Soft Tissue devices consist of non-resorbable devices intended to aid in arthroscopic and orthopaedic reconstructive procedures requiring soft tissue to bone fixation.
Study: NCT05396196

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Kinesio® Tape
Description: Manual Fascial Glide Application

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Kinesio® Tape
Description: Manual Fascial Glide Application
Study: NCT06208111

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: cognitive behavioral therapy
Description: cognitive behavioral therapy would be used as intervention strategy for women facing partner violence to Clear about actual problems, re-educate about the issue of domestic problems and mental health, Logical expectations, Identify negative automatic thoughts,Thinking errors, and Improve understanding to identify which stressors trigger negative emotions. Moreover, this intervention will help to Prepare women how to deal with stress and overcome the reaction.
Study: NCT05515991

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SUPPORT-DIALYSIS with Access to Output Report and Information Hub
Description: SUPPORT-Dialysis is a symptom assessment response toolkit, consisting of a screening and response component. Participants will be screened for symptoms and distress using an electronic assessment(ePROMs). Output reports based on ePROMs scores will be provided to patients as well as the clinical care team.~Participants at Toronto General Hospital will complete the screening every 4 weeks for 6 months, and each time the output report will be provided to both patients and the clinical team.The second, response component of the intervention is the information support and self-management hub (https://symptomcare.org). All participants and the clinical team will be given access to this website, which provides information about self-management for patients as well as management advice for healthcare professionals.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SUPPORT-DIALYSIS Only
Description: SUPPORT-Dialysis screening will also be implemented at Humber River Hospital, but participants and clinical team will not be receiving the output screening report or be given access to the information hub with symptom management resources.
Study: NCT06514313

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitoxantrone Hydrochloride Liposome+Irinotecan+Vincristine
Description: Mitoxantrone hydrochloride liposome will be administered by an intravenous infusion , 4 cycles.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Temozolomide+Irinotecan+Vincristine
Description: Q3W, 4 cycles
Study: NCT05604742

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Belimumab (Benlysta)
Description: Belimumab will be administered intravenously every 2 weeks for 3 cycles and then every 4 weeks for a total of 5 cycles

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Belimumab (Benlysta)
Description: Belimumab will be administered intravenously every 2 weeks for 3 cycles and then every 4 weeks for a total of 5 cycles
Study: NCT06479577

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: ultrasound
Description: ultrasound 1 MHZ continuous for 20 minute with routine physical therapy 3 days /week 150 minutes/ week resistance training 5-10 exercises involving major muscles of leg and foot 3-4 sets per exercise and 10- 15 repetition per set

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: high intensity laser therapy
Description: 905 nm super pulsed laser 40 minute session 3 days /week 150 minutes/ week resistance training 5-10 exercises involving major muscles of leg and foot 3-4 sets per exercise and 10- 15 repetition per set
Study: NCT05816434

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Sleep extension
Description: \>1 hour additional time in bed per night for 1 week.
Study: NCT05595733

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ventilator mode
Description: Neurally Adjusted Ventilatory Assist (NAVA) mode is a new mode of ventilator, using electronic potential of diaphragm to adjust tidal volume. At the same time, this mode can trigger and cycle-off inspiratory time by high sensitivity of electronic potential of diaphragm, increase patient-ventilator synchrony, reduce sedative drug, improve oxygenation, shorten mechanical ventilation day and reduce the rate of diaphragm atrophy. It can improve survival rate and hospital day of patients. Both the animal and human experiment have the effect of lung and diaphragm protection.
Study: NCT06386991

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments
Description: Regenerative endodontic treatment using different irrigation solutions

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments
Description: Regenerative endodontic treatment using different irrigation solutions

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Using ethylenediaminetetraacetic acid (EDTA), citric acid ((MONO/ANH) and etidronic acid (HEBP) to clean root canals during regenerative endodontic treatments
Description: Regenerative endodontic treatment using different irrigation solutions
Study: NCT05270239

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: N-back Cognitive Training
Description: N-back task mainly trains working memory and information processing speed. This training lasts 10 days (1 hour per day).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Virtual Reality Motor and Cognitive Training
Description: Virtual Reality Ball Task mainly trains inhibitory control, attention, working memory and motor functions. This training lasts 10 days (30 minutes per day)
Study: NCT05240625

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: aetherAI Computer-aided Polyp Detection (CADe) Systems for Colonoscopy
Description: The investigational medical device is intended to automatically detect potential polyps via colonoscopy in real-time during colonoscopy examinations.~The subject device contains an artificial intelligence/machine learning (AI/ML) advanced algorithm to aid the endoscopists in detection of colonic mucosal lesions and the detected polyps will be highlighted to the endoscopists during the real-time colonoscopy procedures.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard colonoscopy
Description: Standard colonoscopy procedure.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Standard colonoscopy
Description: Standard colonoscopy procedure.
Study: NCT06339931

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SMWLM combined Spinal traction with belt
Description: Group A, therapist 1 will stand at the participant's ventral side and apply a transverse glide with the thumb on the involved lumbar spinous process. Therapist 2 will then abduct the affected leg by 10° and take the limb gently into hip flexion with the knee extended, while the glide will be sustained continuously by Therapist. Wrap the traction belt around both your hips and the proximal aspect of the patient's thighs.Apply traction by leaning backward and shifting your body weight onto your posterior leg.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: SMWLM combined spinal traction without belt
Description: Group B, therapist 1 will stand at the participant's ventral side and apply a transverse glide with the thumb on the involved lumbar spinous process. Therapist 2 will then abduct the affected leg by 10° and take the limb gently into hip flexion with the knee extended, while the glide will be sustained continuously by Therapist. Manual traction is applied by placing the patient over a rolled pillow while lying sideways. The roll should be 6-8 inches in diameter and should be placed at the level of the spine where the traction or separation is to occur. Pull the patient's legs toward you as you lean your body backward to apply a traction force.
Study: NCT06271733

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: TMS
Description: 2 sessions of iTBS per day for 5 days

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham
Description: 2 sessions per day for 5 days of sham condition
Study: NCT04953533

Intervention type: OTHER
Intervention: no intervention

Intervention type: OTHER
Intervention: no intervention

Intervention type: OTHER
Intervention: no intervention
Study: NCT04826315

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: COPE +
Description: Six sixty minute sessions that teaches participants distress and communication coping skills.
Study: NCT04872790

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dasatinib
Description: Given PO

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methotrexate
Description: Given IT

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Given PO
Study: NCT05870059

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propolis mouthwash
Description: After scaling and root planning at the baseline visit, patients were prescribed to use 5ml of propolis mouthwash twice a day for 6 weeks. patients were also prescribed to not eat and drink anything for half an hour after the rinse.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Chlorhexidine mouthwash
Description: After scaling and root planning at the baseline visit, patients were prescribed to use chlorhexidine mouthwash twice a day for 6 weeks. patients were also prescribed to not eat and drink anything for half an hour after the rinse.
Study: NCT06365411

Intervention type: DIAGNOSTIC_TEST
Intervention: Biomarker discovery and validation - with focus on genomic biomarkers
Description: Biomarker discovery and validation - with focus on genomic biomarkers
Study: NCT05245240

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Dietary and physical intervention
Description: Low-caloric diet (energy deficit 600 kcal/day based on indirect calorimetry measurements), individually tailored by a nutritional specialist according to patients' individual food preferences.~Mild to moderate intensity exercise of aerobic/endurance type, performed 3 times a week for 30-90 minutes.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Dietary and physical intervention
Description: Low-caloric diet (energy deficit 600 kcal/day based on indirect calorimetry measurements), individually tailored by a nutritional specialist according to patients' individual food preferences.~Mild to moderate intensity exercise of aerobic/endurance type, performed 3 times a week for 30-90 minutes.
Study: NCT04872790

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Rituximab
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Given PO

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blinatumomab
Description: Given IV
Study: NCT05063474

Intervention type: DIAGNOSTIC_TEST
Intervention: No Intervention-Clinical Assessments only
Description: No Intervention. Clinical Assessments include: vital signs, near infrared spectrometry, general leg strength, and 6-minute walking test.
Study: NCT05472168

Intervention type: OTHER
Group type: OTHER
Intervention: Olfactory Stimulation
Description: Participants are exposed to different odours and energy expenditure is assessed via indirect calorimetry.

Intervention type: OTHER
Group type: OTHER
Intervention: Olfactory Stimulation
Description: Participants are exposed to different odours and energy expenditure is assessed via indirect calorimetry.
Study: NCT05147194

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trimetazidine
Description: Oral，35mg bid
Study: NCT05076981

Intervention type: DRUG
Intervention: human chorionic gonadotropin
Description: once the dominant follicle reaches 17mm or above, a bolus of 6500 rhCG (Ovitrelle, Merck-Serono) will be administered subcutaneously
Study: NCT04872790

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Aspiration and Biopsy
Description: Undergo bone marrow aspiration and biopsy
Study: NCT06099860

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesio Taping
Description: Kinesio tape with a 5 cm width was used. Participants were positioned on the side lying on the non-involved side with the hip joint of the involved side flexed to 45 degrees and the femur supported in neutral rotation. First, the tape was placed over the area between the ASIS and PSIS to protect the skin. Next, two strips of tape were applied over the first tape to correct anterior innominate rotation. The first piece was applied at the ASIS and pulled firmly to the PSIS in a straight anterior-to-posterior direction. The second piece was applied in an arching manner pulled firmly from the ASIS to the PSIS. the tape was changed once every 3 days

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Balance Training (BT)
Description: The balance training was performed on the Biodex balance system, participants wwere instructed to stand on a podium and stabilize themselves to keep the cursor in the middle of co-centered circle on the displayed screen/monitor. Stability level of platform was set on eight for first two sessions and then reduced to one level on every two sessions so that in the 9th and 10th session the stability level was four. From session four onwards, the participants performed the limit of stability exercises with Biodex Balance System. The participants performed this exercise protocol two times in each session. Total 12 sessions were given in time period of six weeks.
Study: NCT06099860

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Balance Training (BT)
Description: The balance training was performed on the Biodex balance system, participants wwere instructed to stand on a podium and stabilize themselves to keep the cursor in the middle of co-centered circle on the displayed screen/monitor. Stability level of platform was set on eight for first two sessions and then reduced to one level on every two sessions so that in the 9th and 10th session the stability level was four. From session four onwards, the participants performed the limit of stability exercises with Biodex Balance System. The participants performed this exercise protocol two times in each session. Total 12 sessions were given in time period of six weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hot Pack and Stretching Exercises
Description: A hot pack was applied for 20 minutes, stretching exercises were performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hot Pack and Stretching Exercises
Description: A hot pack was applied for 20 minutes, stretching exercises were performed.
Study: NCT06345287

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: radical radiotherapy (60Gy)
Description: concurrent chemoradiotherapy (60Gy) after induction therapy

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: radical radiotherapy (66Gy)
Description: concurrent chemoradiotherapy (66Gy) after induction therapy

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: radical radiotherapy (70Gy)
Description: concurrent chemoradiotherapy (70Gy) after induction therapy

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: anti-PD-1 or PD-L1 antibody
Description: immunotherapy maintenance with anti-PD-1 or PDL1antibody every three weeks for 1 year after radiotherapy

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: anti-PD-1 or PD-L1 antibody
Description: immunotherapy maintenance with anti-PD-1 or PDL1antibody every three weeks for 1 year after radiotherapy

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: anti-PD-1 or PD-L1 antibody
Description: immunotherapy maintenance with anti-PD-1 or PDL1antibody every three weeks for 1 year after radiotherapy
Study: NCT06343259

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: General Anesthesia
Description: After preoxygenation, intravenous fentanyl (1 μg/kg), propofol (2 mg/kg), and rocuronium (0.6 mg/kg) will be used for anesthesia induction. Intubation will be performed with a 7.0-8.0 sized tube, followed by the initiation of mechanical ventilation (tidal volume: 6-8 ml/kg, respiratory rate: 12 breaths/min). Sevoflurane will be used to maintain anesthesia (0.7-1 MAC), and remifentanil infusion will be administered for analgesia. Postoperatively, tramadol (1 mg/kg) and paracetamol (10 mg/kg) will be administered intravenously. Neuromuscular blockade will be reversed using sugammadex. Patients with an Aldrete Recovery Score ≥9 will be transferred to the post-anesthesia care unit after extubation.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Spinal Anesthesia
Description: Patients will be positioned laterally with the hip to be operated on the lower side, and skin asepsis will be ensured, followed by sterile draping. A dural puncture will be performed at the L3-4 spinal level using a 22-25 gauge Quincke-tip spinal needle. After the detection of cerebrospinal fluid, 7.5 mg of 0.5% hyperbaric bupivacaine will be slowly injected. Following a 10-minute interval, the sensory block level will be assessed using the pinprick test and modified Bromage scale, aiming for a T10 sensory block. Surgery will commence upon achieving adequate sensory block. Postoperatively, patients will be transferred to the recovery room. Patients failing to attain sufficient sensory block and experiencing pain will undergo transition to general anesthesia, terminating their cases.
Study: NCT04938882

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Normal saline
Description: Before the induction of anesthesia, normal saline is used for bilateral transversus abdominis plane block in a volume of 20 mL of each side

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ropivacaine
Description: Before the induction of anesthesia, 0.375% ropivacaine is used for bilateral transversus abdominis plane block in a volume of 20 mL of each side