TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05064449

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat
Description: Soticlestat tablets.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat
Description: Soticlestat tablets.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Itraconazole
Description: Itraconazole oral solution.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mefenamic acid
Description: Mefenamic acid capsule.
Study: NCT04806191

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Evidence based treatment strategy
Description: Evidence-based clinical examination and treatment plan

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Targeted patient information package
Description: GPs will in cooperation with the patients tailor a information package targeted to the patients needs regarding their clinical shoulder diagnosis and individual implications and needs (Pain, sleep, exercises etc.).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as usual (TAU)
Description: Usual care as provided by the GP
Study: NCT06119061

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Telavancin Injection
Description: Telavancin 10mg/kg (maximum 1000mg) administered intravenously over 60 minutes (through a central venous catheter whenever available).
Study: NCT05116904

Intervention type: OTHER
Group type: OTHER
Intervention: Assessment
Description: Pupil reflex and melatonin profile, circadian profile assessment

Intervention type: OTHER
Group type: OTHER
Intervention: Assessment
Description: Pupil reflex and melatonin profile, circadian profile assessment
Study: NCT06265116

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: One-step universal adhesive
Description: Each patient will receive a class II restoration using the corresponding group adhesive

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: One-step universal adhesive
Description: Each patient will receive a class II restoration using the corresponding group adhesive

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: One-step universal adhesive
Description: Each patient will receive a class II restoration using the corresponding group adhesive
Study: NCT06550960

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Evaluation of two biopsy systems
Description: Each subject will have prostate biopsy taken in 6 locations in one lobe of the prostate and then biopsy in 6 locations in the other lobe of the prostate

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Evaluation of two biopsy systems
Description: Each subject will have prostate biopsy taken in 6 locations in one lobe of the prostate and then biopsy in 6 locations in the other lobe of the prostate
Study: NCT05670561

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Sufentanil
Description: PCIA formula#100ml analgesic solution was prepared by adding 2 μ g/kg sufentanil and 8mg ondansetron into normal saline. 30min before TACE treatment, the first dose of 2ml was slowly injected intravenously.No obvious adverse reactions were observed for 10min. The PCIA pump was commenced at the beginning of TACE. Parameter setting of intravenous analgesia pump: the total volume is 100ml; The duration is 2ml / h; The single dose is 2ml each time; The limit quantity is 10ml / h; The locking time was 10min and the analgesia lasted for 48h. The target value of analgesia in this study was NRS (Numerical Rating Scale)\< 4; If NRS ≥ 4, when the effect is still poor after adding drugs by pressing the analgesic pump, the investigators will give the remedial drug(dolantin 50mg im st) according to the patient's condition.
Study: NCT05570409

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Mycophenolate Mofetil Placebo
Description: MMF matching Placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Prednisolone Placebo
Description: Prednisolone matching placebo
Study: NCT06459336

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intensive constraint-induced movement therapy
Description: Intensive protocol of CIMT will be given for 6hrs for 6 days to make total of 36 hours

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Distributed constraint-induced movement therapy
Description: Distributed protocol of CIMT will be given for 2.25hrs two times a week for 8 weeks making total of 36 hours
Study: NCT04706000

Intervention type: GENETIC
Intervention: Beclin 1 gene
Description: The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.

Intervention type: GENETIC
Intervention: Beclin 1 gene
Description: The determination of Beclin 1, LC3-II and p62 genes, which are evaluated by immunohistochemistry, at the protein level will be done by ELISA method in MSKU Medical Faculty Medical Biology Laboratory.
Study: NCT06265116

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: One-step universal adhesive
Description: Each patient will receive a class II restoration using the corresponding group adhesive
Study: NCT06228586

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Meningococcal Polysaccharide (Serogroups A, C, W, and Y) Tetanus Toxoid Conjugate Vaccine
Description: Pharmaceutical form:Liquid solution-Route of administration:Intramuscular injection
Study: NCT05462197

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Qigong Wuqinxi
Description: Wuqinxi is an exercise method developed by the ancient Chinese physician Hua Tuo by combining the ancient guide, breathing, and imitating the shapes of five animals, such as tiger, deer, bear, ape, and bird, combined with the zang-fu and meridian theory of traditional Chinese medicine. There have been studies in the past proven that this exercise can achieve health-promoting effects
Study: NCT05643261

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Muscle and technique training
Description: The strength training consists of three exercises (clam shell, side plank, calf raises) with an progressive overload after two to three weeks to ensure a continuous muscle stimulation. The technique training consists of different cutting variations with a focus on forefoot landings and conscious control of the knee to avoid high knee valgus movement and KAM respectively.
Study: NCT05106244

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Real-Time Guidance of Home Care for Patients with PICC or PORT
Description: the experimental group adopted the family self-nursing mode, mainly by the patients' family members to observe the catheter and do regular nursing, and the specialist nurses provided remote real-time online guidance to monitor the family nursing of central venous catheter. The procedures are as follows: (1) make nursing videos recorded by central venous catheter specialist nurses; (2) evaluate the nursing operation ability of the patients' family members and carry out relevant training and health education, repeat until they are qualified; (3) distribute nursing guidance prescriptions and maintenance manuals for central venous catheters; (4) provide online simulated realistic nursing video materials; (5) provide real-time telephone audio and video connection to complete remote nursing guidance. (6) set up a home nursing volunteer service group, establish a doctor-patient exchange group by using Wechat and other media.
Study: NCT05796011

Intervention type: DEVICE
Intervention: hearing aids
Description: Hearing aid(s) fitted for one or two sides of ear.

Intervention type: OTHER
Intervention: without hearing intervention
Description: neither earing aids nor other heaing treatment were applied.

Intervention type: OTHER
Intervention: healthy control
Description: healthy control
Study: NCT06070831

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Inspiratory muscle training
Description: Respiratory training, performed through IMT, was carried out with a pressure threshold device (Treshold IMT, Philips-Respironics, Pittsburg, PA, USA). Threshold IMT offers a constant and specific pressure for strength and endurance training of the respiratory muscles, regardless of the strength or speed with which patient breathes. A flow-independent one-way valve ensures constant resistance and allows you to specifically adjust workload (in cmH2O). The training must be supervised by a healthcare professional. During the inspiration, a spring-loaded valve resists to stimulate the training of the respiratory muscles. Before training began, the participants and primary caregivers completed one-session familiarization with a specialist to know the operation of the device.~Adult people with acquired brain injury carried out the training program for 8 weeks, 1 session every day, 5 days a week. The participants performed 5 series of 1 minute with 1-minute rest between them.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Expiratory muscle training
Description: Respiratory training, performed through PEP, was carried out with a pressure threshold device (Treshold PEP, Philips-Respironics, Pittsburg, PA, USA). Threshold PEP offers a constant and specific pressure for strength and endurance training of the respiratory muscles, regardless of the strength or speed with which patient breathes. A flow-independent one-way valve ensures constant resistance and allows you to specifically adjust workload (in cmH2O). The training must be supervised by a healthcare professional. During the expiration, a spring-loaded valve resists to stimulate the training of the respiratory muscles. Before training began, the participants and primary caregivers completed one-session familiarization with a specialist to know the operation of the device.~Adult people with acquired brain injury carried out the training program for 8 weeks, 1 session every day, 5 days a week. The participants performed 5 series of 1 minute with 1-minute rest between them.
Study: NCT06421727

Intervention type: OTHER
Group type: OTHER
Intervention: Rehabilitation by optokinetic stimulation and virtual reality exercises .
Description: Rehabilitation by optokinetic stimulation and virtual reality exercises(by deviceVirtual reality system(Meta Quest 2_Advanced All-In-One Virtual Reality Headset_ 128 GB)).
Study: NCT06303011

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Transcutaneous Electrical Nerve Stimulator
Description: TENS will be applied on sacral and parasacral area. Frequency 10Hz, Pulse duration 200μs, Stimulation duration 20min
Study: NCT05463510

Intervention type: DIAGNOSTIC_TEST
Intervention: Videodermoscopy
Description: Patients who had records for at least twice with videodermoscopy every 3 months were included.
Study: NCT04896710

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SD Biosensor
Description: Nasal swab SD biosensor to be self administered
Study: NCT04665050

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: V116
Description: Pneumococcal 21-valent conjugate vaccine with 2 μg of each of the following pneumococcal polysaccharides (PnPs) antigen: 3, 6A, 7F, 8, 9N, 10A, 11A, 12F, 15A, 15C, 16F, 17F, 19A, 20A, 22F, 23A, 23B, 24F, 31, 33F, and 35B in each 0.5 mL sterile solution

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: PNEUMOVAX™23
Description: Pneumococcal 23-valent polyvalent vaccine with 25 μg of each of the following PnPs antigen: 1, 2, 3, 4, 5, 6B, 7F, 8, 9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C, 19A, 19F, 20, 22F, 23F, and 33F in each 0.5 mL sterile solution
Study: NCT05266092

Intervention type: OTHER
Intervention: Observational study
Description: Observational study

Intervention type: OTHER
Intervention: Observational study
Description: Observational study

Intervention type: OTHER
Intervention: Observational study
Description: Observational study

Intervention type: OTHER
Intervention: Observational study
Description: Observational study
Study: NCT04716127

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Proximity-incentive strategy based on vaginal self-sampling for women 50 to 65 years who do not participate to cervical cancer screening
Description: * Direct offer of a vaginal self-sampling kit with information to perform at home and send back to the laboratory for HR-HPV testing~* The psychosocial determinants involved in decision-making process and compliance to cervical cancer screening will be collected from open questionnaires and by semi-directive phone interviews~* Control ; Receive reminder to send the self-sample to the laboratory : After 3 and 6 months without return, women receive a remind letter to send the vaginal self-sample to the laboratory. We call return the receipt of the vaginal self-sample at the laboratory.~* Control ; Receive reminder to perform cervical smear in case of positive HR-HPV test : In case of a positive HR-HPV test, women are asked to perform a control cervical smear. After 3, 6 months and 12 months without return, women and their health-care professional will receive a remind letter or a call to perform a cervical smear for control. We call return the performance of a pap smear.
Study: NCT05004376

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Text Messaging
Description: Text messages based on behavioral theory to encourage scheduling colorectal cancer screening.
Study: NCT06328153

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Fu's Subcutaneous Needling
Description: Operation of the FSN will follow the KOA's Fu's Subcutaneous Needling Treatment Code of Practice24. After routine disinfection, a disposable Fu's subcutaneous needle ( Nanjing-Paifu Medical Technology Co., Ltd., Jiangsu, China ) is inserted parallel into the subcutaneous loose connective tissue of the pathological tight muscles ( gastrocnemius muscle, tibial anterior muscle and quadriceps femoris muscle ). The FSN needle is operated in a swaying movement. The fan angle is approximately 60°; perform a total of 45 round trips in 30 seconds. Swaying is accompanied by reperfusion approach: 20 sweeps with 10 seconds of reperfusion approach as a group, 3 groups for each pathological tight muscle. The reperfusion approach requires active, short and sharp contractions of the pathological tight muscle. The muscle alternates contraction and relaxation. The FSN group is treated 3 times a week for 2 weeks.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Celecoxib
Description: Participants in the drug group will receive celecoxib (capsule) 200mg every day continuously for 2 weeks.
Study: NCT04697693

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Escitalopram
Description: The participant will be begun on either escitalopram 10mg or duloxetine 30mg. Subjects will begin escitalopram 10mg, continue this dosage for 4 weeks, then if the HRSD \>7 at Week 4, he/she will have their dosage increased to 20mg for the remainder of the 8 week study.
Study: NCT06303011

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: TENS on para sacral area with Abdominal Massage
Description: TENS on para sacral area with Abdominal Massage. Frequency 10Hz Pulse duration 200μs Stimulation duration 20min
Study: NCT04697693

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Duloxetine
Description: Participants who have not responded to or not tolerated escitalopram in the current depressive episode will be started on duloxetine. They will take 30mg for the first 2 weeks, then, contingent on clinical assessment that the 30mg dose is sufficiently well tolerated, be increased to 60mg for the remaining 6 weeks of the study.
Study: NCT05451979

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MedBIKE HIIT
Description: Participants will complete a high intensity interval training exercise program 3 times a week for 12 weeks (36 sessions total)
Study: NCT05818579

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual reality experience
Description: The VR experience is launched on the participants using all-in-one VR head-mount devices. Tablet computers are used to optimize the settings by the intervention facilitators. Each session lasts for approximately one hour with 10 minutes spent on the briefing, 20 minutes spent on the VR experience, and 30 minutes spent on the post-VR group discussion. There are two sessions per week. The whole course lasts for six weeks and there are a total of 12 sessions.
Study: NCT05298748

Intervention type: OTHER
Group type: OTHER
Intervention: Womb sound recordings
Description: Womb sounds will be chosen from commercially available (Amazon) womb recordings using a recording that most closely resembles the womb including maternal heart rate, fetal heartbeat, respiratory sounds, bowel popping sounds and frequency spectra as described by Parga, Daland 2018 et al.

Intervention type: OTHER
Group type: OTHER
Intervention: Womb sound recordings
Description: Womb sounds will be chosen from commercially available (Amazon) womb recordings using a recording that most closely resembles the womb including maternal heart rate, fetal heartbeat, respiratory sounds, bowel popping sounds and frequency spectra as described by Parga, Daland 2018 et al.
Study: NCT06151587

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QLM3004 Concentration 1
Description: Low dose of QLM3004 Ophthalmic Solution~1 drop in each eye at bedtime

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QLM3004 Concentration 2
Description: Medium dose of QLM3004 Ophthalmic Solution~1 drop in each eye at bedtime
Study: NCT05450380

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LIFT001
Description: The dermal filler of hyaluronic acid LIFT001 is applied to the facial area to provide firmness and counteract sagging for the correction of deep wrinkles and imperfections of face.~The dermal filler of hyaluronic acid LIFT001 is applied to the facial area to provide firmness and counteract sagging for the correction of deep wrinkles and imperfections of face.
Study: NCT06334068

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Short-term glycemic control group
Description: Patients will be admitted to the hospital for 2-3 days before surgery. During this pilot study, patients will be admitted to the intermediate care unit to monitor and control preoperative blood glucose. We aim to maintain moderate glucose control (140-180 mg/dl) using the basal-bolus insulin protocol, plus correctional doses as needed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard-of-care group
Description: Patients will be admitted the day before surgery with the usual patient treatment.
Study: NCT06190080

Intervention type: OTHER
Group type: OTHER
Intervention: Digestive endoscopy
Description: Digestive endoscopies are performed in the operative room under general anaesthetic 3 months after the introduction or change of treatment. Biopsies of the upper, middle and lower thirds of the esophagus will be taken and analyzed for pathology.
Study: NCT05196685

Intervention type: DIAGNOSTIC_TEST
Intervention: Carotid Doppler USG
Description: All Doppler ultrasonography measurements will be made in a dimly lit room at room temperature, with the patient in the supine position, the head slightly hyperextended, the patient looking to the left when measuring the right side, and the patient looking to the right when measuring the left side. In all patients, common carotid artery (CCA), internal carotid artery (ICA) and vertebral artery (VA) gray scale and color Doppler ultrasonography wşll be performed using the GE 9L Linear Probe. Color Doppler examination will be performed with a frequency of 4.0/8.0 MHz.
Study: NCT06372574

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RO7617991
Description: RO7617991 will be administered by intravenous (IV) infusion. Treatment will continue until unacceptable toxicity or loss of clinical benefit as determined by the investigator.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tocilizumab
Description: Tocilizumab 8 mg/kg IV will be administered to patients when necessary to treat potential cytokine release syndrome (CRS), as described in the protocol.
Study: NCT05607862

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home Physiotherapy Group
Description: The intervention group will receive 2 sessions per week for 8 weeks supervised and assisted by a physiotherapist at the patient's home. Muscle strengthening exercises of the lower and upper limbs, stretching, coordination and balance exercises, gait re-education with the relevant technical aids, a pattern of exercises to be performed daily by the patient and health education guidelines will be carried out.

Intervention type: OTHER
Group type: OTHER
Intervention: Control Group
Description: The control group will be given health education guidelines and will continue with their usual medical-pharmacological treatment. All patients included in this study will receive physiotherapy treatment, and those in the control group will be treated once the intervention and the post-intervention assessment have been completed.
Study: NCT05659563

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Giredestrant
Description: Giredestrant is a highly potent, non-steroidal, oral selective ER antagonist and degrader (SERD)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tamoxifen
Description: Tamoxifen is a selective estrogen receptor (ER) modulator
Study: NCT06533930

Intervention type: OTHER
Intervention: Transorbital Sonography
Description: OND and ONSD of participants in the MS patient group and healthy control group were measured by TOS.

Intervention type: OTHER
Intervention: Transorbital Sonography
Description: OND and ONSD of participants in the MS patient group and healthy control group were measured by TOS.

Intervention type: OTHER
Intervention: Orbita Magnetic Resonance Imaging
Description: OND and ONSD of participants in the MS patient group were measured by orbita MRI.

Intervention type: OTHER
Intervention: Visual Evoked Potentials
Description: P100 amplitude and P100 latency values of participants in the MS patient group were measured by VEP.

Intervention type: OTHER
Intervention: Optical Coherence Tomography
Description: pRNFL thickness of participants in the MS patient group were measured by OCT.
Study: NCT06077682

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclopentolate
Description: Well-known eye drop used for cycloplegic refraction among children.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tropicamide
Description: Well-known eye drop used for cycloplegic refraction among children.
Study: NCT05713929

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Recruitment maneuver (RM)
Description: performance of a recruitment maneuver of 30 cm H20 for 30 seconds and measurement of electrical impedance

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Reverse Trend (REV TREND)
Description: Place the patient in the reverse trendelenburg position and measuring the electrical impedance after 5 minutes
Study: NCT06151587

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QLM3004 Concentration 3
Description: High dose of QLM3004 Ophthalmic Solution~1 drop in each eye at bedtime

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Vehicle
Study: NCT06091280

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Respiratory Muscle Strength Trainers
Description: Devices provided to each participant. Resistance loading set at less than 50% of the peak inspiratory and peak expiratory flow rate.