TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06267443

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Comparison of erector spina plane block, parasternal block plus local infiltration to the tube sides for postoperative analgesia
Description: Group 1: erector spina plane block: With USG guidance at the thoracal level of 4-5, with 20ml 2.5% bupivacaine ESPB will be performed. after surgery in the ICU pain score and atelectasia will be evaluated.~Group 2: With USG guidance parasternal block will be performed after intubation bilaterally with 10 ml 0.25% bupivacaine each side. at the end of the surgery infiltration of chest tube sides will be performed with 10 ml 2.5% bupivacain.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Comparison of erector spina plane block, parasternal block plus local infiltration to the tube sides for postoperative analgesia
Description: Group 1: erector spina plane block: With USG guidance at the thoracal level of 4-5, with 20ml 2.5% bupivacaine ESPB will be performed. after surgery in the ICU pain score and atelectasia will be evaluated.~Group 2: With USG guidance parasternal block will be performed after intubation bilaterally with 10 ml 0.25% bupivacaine each side. at the end of the surgery infiltration of chest tube sides will be performed with 10 ml 2.5% bupivacain.
Study: NCT06154395

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: OCT-guided PCI
Description: The OCT guidance team routinely conducts OCT examinations on patients after standard angiography and/or thrombus aspiration. The OCT examination follows a standard procedure. The operator evaluates the stability of the lesion and decides whether to proceed with stent implantation therapy (with the option to choose the type of stent) or opt for conservative medical treatment. If a stent is implanted, the procedure is carried out according to guidelines and standard protocols, with the landing zone of the stent determined based on OCT image features. After stent implantation, a follow-up OCT examination of the stent segment, as well as angiographic examination, is performed. Based on the OCT results, the operator decides whether post-dilation is necessary.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: 60 MHz HD-IVUS-guided PCI
Description: The IVUS guidance team routinely conducts IVUS examinations on patients after standard angiography and/or thrombus aspiration. The IVUS examination follows a standard procedure. The operator evaluates the stability of the lesion and decides whether to proceed with stent implantation therapy (with the option to choose the type of stent) or opt for conservative medical treatment. If a stent is implanted, the procedure is carried out according to guidelines and standard protocols, with the landing zone of the stent determined based on IVUS image features. After stent implantation, a follow-up IVUS examination of the stent segment, as well as angiographic examination, is performed. Based on the IVUS results, the operator decides whether post-dilation is necessary.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Angiography-guided PCI
Description: After routine angiography and/or thrombus aspiration, the operator assesses the lesion based on treatment standards to determine whether stent implantation is necessary. For patients undergoing stent implantation, a follow-up angiography is performed postoperatively, and the decision for post-dilation is made by the operator based on experience.
Study: NCT06538740

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ventilating the patient with 70% (instead of standardized 100%) oxygen concentration during the wash out phase, before extubation.
Description: The investigated intervention is the application of 70% inspired oxygen compared to 100% inspired oxygen during the anesthetic washout, right before extubation of the patient. Before and after the intervention EIT measurements are performed at designated time points to assess lung aeration and calculate the center of ventilation. This information allows assumptions on atelectasis formation in the patients' lung.
Study: NCT06647719

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Educational Videos
Description: Subjects in the experimental group will be provided with 3 links to videos to be watched after CTR surgery. These videos will be available through YouTube, Twitter, Facebook, Instagram, TikTok, or MyChart. Videos will be available to watch multiple times at the subjects choice.
Study: NCT06647992

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nurse Navigation Program
Description: It is planned to provide Cervical Cancer Education and Counseling to women in the experimental group about cervical cancer. Training and counseling is planned to be implemented face to face. An information booklet will be given to the experimental group. After 30 and 60 days after the training and counseling given to the experimental and control groups, it was planned to provide online (WhatApp) training and counseling to the patients in the experimental group:~Participants will be given a contact number that they can reach during the day when they want to receive counseling about HPV-DNA or Pap smear. Interviews will be scheduled between 08.00-20.00.~Individuals who are not screened will receive a reminder message by phone on the 45th and 75th day. Transtheoretical Model In the study, interventions will be planned for the experimental group according to the stages of the transtheoretical model.~The researcher will conduct motivational interviews with the individuals.
Study: NCT06591884

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tacrolimus modified-release
Description: 0.08% tacrolimus nanoencapsulated aqueous solution spray

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: tacrolimus ointment 0.1%
Description: 0.1% free tacrolimus commercial ointment
Study: NCT06602271

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF614 capsule
Description: Experimental oxycodone prodrug

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF614 capsule
Description: Experimental oxycodone prodrug

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF614 capsule
Description: Experimental oxycodone prodrug

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Inactive medication

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oxycodone HCl 10 mg
Description: Active comparator
Study: NCT06664320

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Acute normovolemic hemodilution (ANH)
Description: applying acute normovolemic hemodilution (ANH) by using HES 130/0.4 of 5 ml/kg before the initiation of cardiopulmonary bypass

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: hydroxyethyl starch (HES 130/0.6)
Description: hydroxyethyl starch (HES 130/0.6)
Study: NCT06610201

Intervention type: OTHER
Intervention: Clinical outcomes of patients with VWD, Type 1 (less than 40 IU per dL)
Description: Accumulate information regarding bleeding events, quality of life, and the social and clinical impact of bleeding events in participants with VWD, Type 1 (less than 40 IU per dL).

Intervention type: OTHER
Intervention: Clinical outcomes of patients with VWD, Type 1 (less than 50 IU per dL)
Description: Accumulate information regarding bleeding events, quality of life, and the social and clinical impact of bleeding events in participants with VWD, Type 1(less than 50 IU per dL).

Intervention type: OTHER
Intervention: Clinical outcomes of patients with VWD, Type 2 and Type 3
Description: Accumulate information regarding bleeding events, quality of life, and the social and clinical impact of bleeding events in participants with VWD, Type 2 and Type 3.
Study: NCT04822194

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Emotion Regulation Training
Description: Cognitive emotion regulation training via cognitive reappraisal involves the ability to modify the trajectory of an emotional response by thinking about and appraising emotional information in an alternative, more adaptive way. Reappraisal to down-regulate negative emotion can be operationalized via two tactics: psychological distancing and reinterpretation. The current study will randomly assign participants to receive a brief course of reappraisal training using either psychological distancing or reinterpretation.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Emotion Regulation Training
Description: Cognitive emotion regulation training via cognitive reappraisal involves the ability to modify the trajectory of an emotional response by thinking about and appraising emotional information in an alternative, more adaptive way. Reappraisal to down-regulate negative emotion can be operationalized via two tactics: psychological distancing and reinterpretation. The current study will randomly assign participants to receive a brief course of reappraisal training using either psychological distancing or reinterpretation.
Study: NCT06597565

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemcitabine
Description: Gemcitabine is a standard of care given at ultralow dose in combination with the experimental drug ACR-368.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemcitabine
Description: Gemcitabine is a standard of care given at ultralow dose in combination with the experimental drug ACR-368.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ACR-368
Description: ACR-368 is an experimental drug.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ACR-368
Description: ACR-368 is an experimental drug.
Study: NCT06614998

Intervention type: DRUG
Intervention: Patients diagnosed with HLH-94 should be treated as soon as possible
Description: For some highly suspicious patients, after diagnosis, according to the patient's etiology, the treatment plan should be determined as soon as possible, such as lymphoma-related patients treated with hormones combined with etoposide, which can greatly improve the prognosis of patients
Study: NCT05279729

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mobile health application
Description: Intervention will be with two different mobile health (mHealth) applications, Weight Watchers and Healthi app (formerly iTrackBites)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mobile health application
Description: Intervention will be with two different mobile health (mHealth) applications, Weight Watchers and Healthi app (formerly iTrackBites)
Study: NCT06621108

Intervention type: OTHER
Intervention: Focus group session
Description: Participants will take part in a focus group, which includes sharing their experience of the four-week feeling tone mindfulness course in an online group session. The focus group session will be led by trained moderator, and attended by several other course participants who completed the four-week feeling tone mindfulness course. The session will be audio-recorded as the research team will analyze the qualitative feedback offered by participants.
Study: NCT06619379

Intervention type: OTHER
Group type: OTHER
Intervention: retention time of speculum
Description: according to the randomization, the speculum can be extracted :~1. just after the transfer catheter is withdrawn~2. 60 seconds after the transfer catheter is withdrawn~3. 420 second (7 minutes) after the catheter is withdrawn

Intervention type: OTHER
Group type: OTHER
Intervention: retention time of speculum
Description: according to the randomization, the speculum can be extracted :~1. just after the transfer catheter is withdrawn~2. 60 seconds after the transfer catheter is withdrawn~3. 420 second (7 minutes) after the catheter is withdrawn
Study: NCT06620601

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Portable Polysomnography
Description: Research assistants set up the portable polysomnography (Prodigy) for the overnight sleep study.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Treatment
Description: Based on the decision aid, patient preference, and CADTH recommendations, the sleep physicians will recommend the participant to use Auto-CPAP or MAD for six months.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaires
Description: Participants will complete eleven questionnaires: Stop-Bang, Insomnia severity index, Epworth sleepiness score (ESS), quality of life (FOSQ-10), Beck Depression Inventory (BDI), Chalder Fatigue Scale (CFQ), primary care post-traumatic stress disorder (PTSD) scale (PC-PTSD-5), Asthma control questionnaire (ACQ), OHIP-14, and Participant demographics. The RA will help the participants complete the questionnaires (\~one and a half hours in total).

Intervention type: OTHER
Group type: OTHER
Intervention: Questionnaires
Description: Participants will complete eleven questionnaires: Stop-Bang, Insomnia severity index, Epworth sleepiness score (ESS), quality of life (FOSQ-10), Beck Depression Inventory (BDI), Chalder Fatigue Scale (CFQ), primary care post-traumatic stress disorder (PTSD) scale (PC-PTSD-5), Asthma control questionnaire (ACQ), OHIP-14, and Participant demographics. The RA will help the participants complete the questionnaires (\~one and a half hours in total).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaires
Description: Participants will complete eleven questionnaires: Stop-Bang, Insomnia severity index, Epworth sleepiness score (ESS), quality of life (FOSQ-10), Beck Depression Inventory (BDI), Chalder Fatigue Scale (CFQ), primary care post-traumatic stress disorder (PTSD) scale (PC-PTSD-5), Asthma control questionnaire (ACQ), OHIP-14, and Participant demographics. The RA will help the participants complete the questionnaires (\~one and a half hours in total).
Study: NCT06619925

Intervention type: BEHAVIORAL
Intervention: after-school extended sports service
Description: Impact of voluntary participation in different types (e.g. outdoor physical activities, indoor physical activities, ball games, calisthenics, etc.), intensity and duration of after-school extended physical education services on children\&#39;s myopia and other physical and psychological well-being

Intervention type: BEHAVIORAL
Intervention: non-after school extended sports service
Description: Students in the same grade as the exposure group but participating in after-school non-physical education extended services (e.g., homework help, static activities such as calligraphy, chess, etc.) served as a control group, aiming to maximise the control of the influence of potential factors other than physical activity on the results of the study.
Study: NCT06621641

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: The new HFNC weaning protocol
Description: Patients will be randomly assigned to two groups: one following the new HFNC weaning protocol and another using the standard care protocol. The new protocol includes stepwise flow reduction based on the patient's clinical stability and uses the Respiratory Assessment Scale (RAS) to monitor weaning progress. The protocol emphasizes a multidisciplinary approach involving pediatricians, nurses, and respiratory therapists, with consistent training and application of weaning criteria
Study: NCT06620887

Intervention type: OTHER
Intervention: Evaluate the impact of HEMAGO program on maternal morbidity and mortality in sickle cell disease patients during their pregnancies.
Description: HEMAGO pregnancy monitoring is a joint consultation program between the sickle cell disease hematologist and an obstetrician. This program was implemented in April 2016 at the Croix-Rousse maternity Hospital. This program offers close, complete and personalized pregnancy monitoring for each patient with major sickle cell syndrome.~These are follow-up consultations once a month until 24 weeks then every 15 days until delivery. At each consultation, doctors evaluate a general and obstetric clinical examination. The team establishes a precise schedule adapted to each patient for pregnancy monitoring : monthly blood tests, monthly ultrasounds with maternal and fetal Doppler, adaptation of basic treatment, transfusion exchange program according to eligibility criteria, and organization of childbirth.

Intervention type: OTHER
Intervention: Evaluate the impact of HEMAGO program on maternal morbidity and mortality in sickle cell disease patients during their pregnancies.
Description: HEMAGO pregnancy monitoring is a joint consultation program between the sickle cell disease hematologist and an obstetrician. This program was implemented in April 2016 at the Croix-Rousse maternity Hospital. This program offers close, complete and personalized pregnancy monitoring for each patient with major sickle cell syndrome.~These are follow-up consultations once a month until 24 weeks then every 15 days until delivery. At each consultation, doctors evaluate a general and obstetric clinical examination. The team establishes a precise schedule adapted to each patient for pregnancy monitoring : monthly blood tests, monthly ultrasounds with maternal and fetal Doppler, adaptation of basic treatment, transfusion exchange program according to eligibility criteria, and organization of childbirth.
Study: NCT06621316

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535 Tablet
Description: at multiple dose levels

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535 Tablet
Description: at multiple dose levels

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535 Tablet
Description: at multiple dose levels

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535 Tablet
Description: at multiple dose levels

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: at multiple dose levels (matching active arm HRS-7535 Tablet)

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: at multiple dose levels (matching active arm HRS-7535 Tablet)

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: at multiple dose levels (matching active arm HRS-7535 Tablet)

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: at multiple dose levels (matching active arm HRS-7535 Tablet)
Study: NCT06621693

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneous electrical diaphragmatic stimulation intervention
Description: It will be applied on diaphragm, 30 min per session ,3 days/week for 4 weeks at a stimulation frequency of 30 Hz, pulse width of 400 μs, the intensity was gradually increased until visible muscle contraction was observed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: traditional physiotherapy program
Description: The participants will receive traditional physiotherapy ( postural drainage, percussion , diaphragmatic breathing, phase 1 cardiac Rehabilitation and balance training ) three times per week for 4 weeks

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: traditional physiotherapy program
Description: The participants will receive traditional physiotherapy ( postural drainage, percussion , diaphragmatic breathing, phase 1 cardiac Rehabilitation and balance training ) three times per week for 4 weeks
Study: NCT06621134

Intervention type: OTHER
Intervention: AI Chatbot
Description: Participants will be required to provide consent for randomization when they first access our system. Users can ask questions covered by the question bank, as well as specific questions not covered by the bank, through an AI chatbox. The aim is to understand the significant difference between using AI chatbots and telephone hotlines to assist parents, as well as the effectiveness of AI chatbots compared to telephone hotlines.

Intervention type: OTHER
Intervention: Telephone hotline
Description: Participants will be asked to consent to randomization on their first access to our system. Users ask questions covered by the question bank and specific questions not covered by the question through a telephone hotline.
Study: NCT06621030

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MIB Breath Analyzer
Description: Going through visit-specific blood glucose excursions by the administration of glucose and insulin (clamp), monitoring physiological processes, and measuring reference blood glucose values and VOC measurements in the breath using a GC IMS and the MIBs (investigational devices). Going through visit-specific blood glucose excursions by consuming a standardized meal, monitoring physiological processes, and measuring reference blood glucose values and VOC measurements in the breath using a GC-IMS and the MIBs (investigational devices) Imitating the glucose excursion from the meal excursion by infusing glucose and insulin (clamp), monitoring physiological processes, and measuring reference blood glucose values and VOC measurements in the breath using a GC-IMS and the MIBs (investigational devices).
Study: NCT06621563

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined HS-20093
Description: HS-20117 + HS-20093

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined HS-20093
Description: HS-20117 + HS-20093

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined HS-20093
Description: HS-20117 + HS-20093

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined Platinum-containing chemotherapy
Description: HS-20117 + cisplatin/carboplatin + pemetrexed

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined Platinum-containing chemotherapy
Description: HS-20117 + cisplatin/carboplatin + pemetrexed

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined Platinum-containing chemotherapy
Description: HS-20117 + cisplatin/carboplatin + pemetrexed

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined HS-20093 and 5-FU
Description: HS-20117 + HS-20093 + 5-FU

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-20117 combined HS-20093 and 5-FU
Description: HS-20117 + HS-20093 + 5-FU
Study: NCT06623708

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SMARTCLOTH
Description: The intervention consists of using SMARTCLOTH. This device makes it possible to monitor dietary intake throughout the day and record it in a database that, through a website, allows to track it. SMARTCLOTH is a digital tablecloth consisting of a scale, several buttons and a screen. The device allows weighing the food to be consumed and recording its nutritional value (macronutrients in grams, macronutrient servings and kilocalories). The latter is achieved because SMARTCLOTH allows the patient to select to which food group the food being weighed belongs, increasing the accuracy of the nutritional estimation.
Study: NCT06622382

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bariatric endoscopic antral myotomy
Description: A mucosal incision is performed using a triangle-tip knife J at the level of the incisura along the level of the greater curvature. Submucosal tunneling is then performed and stopped immediately proximal to the pylorus. Two parallel lines of partial thickness myotomy are then performed from the distal to proximal antrum using the same endoscopic knife. The myotomy is stopped approximately 2 cm distal to the mucosal incision site. Finally, the mucosal incision is closed using endoclips after haemostasis is confirmed.
Study: NCT06623136

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ES102
Description: ES102 is administered via intravenous infusion, once every 21 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab
Description: Toripalimab is administered via intravenous infusion, once every 21 days.