TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06243354

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Test product: HYP-2090PTSA
Description: Dosage form: Capsule. Strength: 2.5 mg, 5 mg. Method of administration: Oral; Dose escalation: a fixed dose QD is planned, and all other dose levels and administration methods are temporary with the exception of the initial dose. Dose expansion: the dose and method of administration are conducted as discussed by the sponsor and investigators.~Medication cycle: Take orally under fasting condition every morning, with 21 days as a cycle (tentative), and continue taking until disease progression, or intolerable toxicity, or withdrawal of informed consent, or treatment with another antitumor drug, or the death of the subject, or loss to follow-up (whichever occurs earliest).
Study: NCT03035838

Intervention type: DRUG
Group type: OTHER
Intervention: Fosaprepitant
Description: Within 24 hours from injury, IVAMEND (the intravenous formulation of the NK-1 antagonist fosaprepitant) will be administered at a dose of 300 mg, intravenously over 1 hour.
Study: NCT06311279

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Anterior resection of Rectal cancer
Description: Anterior resection of cancer rectum and type of anastomosis (End to end or side to end)
Study: NCT05653713

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CSL324
Description: Single intravenous (IV) dose of CSL324

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: IV dose of 0.9% saline
Study: NCT03814109

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LENINGRADO association
Description: 1 coated sustained-release tablet, oral, once a day.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Indapamide SR 1.5 MG
Description: 1 coated sustained-release tablet, oral, once a day.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levamlodipine 2.5/ 5 mg
Description: 1 tablet, oral, once a day.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Leningrado association Placebo
Description: 1 coated sustained-release tablet, oral, once a day.
Study: NCT04861857

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Parmigiano Reggiano
Description: subjects will receive 50 g/die of the dietary supplement
Study: NCT03814109

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Leningrado association Placebo
Description: 1 coated sustained-release tablet, oral, once a day.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Indapamide SR Placebo
Description: 1 coated sustained-release tablet, oral, once a day.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Indapamide SR Placebo
Description: 1 coated sustained-release tablet, oral, once a day.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Levamlodipine placebo
Description: 1 tablet, oral, once a day.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Levamlodipine placebo
Description: 1 tablet, oral, once a day.
Study: NCT04861857

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Whey Protein
Description: subjects will receive 20 g/die of the dietary supplement
Study: NCT05024851

Intervention type: OTHER
Intervention: Questionnaires
Description: Evaluation of the Psychogenic and Neurogenic Components using questionnaires

Intervention type: OTHER
Intervention: Questionnaires
Description: Evaluation of the Psychogenic and Neurogenic Components using questionnaires
Study: NCT04826601

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: essential oils
Description: A total of 40 cancer patients receiving chemotherapy will be recruited as participants in this study. Blood orange and rosewood will be chosen as the essential oils for aromatherapy in this study. Essential oils will be applied to all participants by inhalation for 30 minutes.
Study: NCT06385743

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Neuromuscular Training-based Exercise Program
Description: Neuromuscular training has been accepted as an effective treatment modality to improve the neurophysiological states of the joints for coordinated work. In addition to shoulder strength, stabilization and kinetic chain exercises, this program includes internal and external focus (sound, touch, light, dual task, etc.), sport-specific exercises and plyometric exercises (speed, agility). All athletes with shoulder pain will include in the baseline evaluation at the beginning of the season and all parameters will be followed throughout the season for 8 weeks. All athletes in this group will participate in a total of 24 physiotherapy sessions, 3 days a week, for eight weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: ''Thrower's Ten'' Exercise Program
Description: ''Thrower's Ten'' Exercise Program includes 10 different shoulder strengthening and shoulder stabilization exercises in a diagonal pattern. Advanced Thrower's Ten exercises that include kinetic chain exercises (covering more than one joint) in addition to shoulder exercises planned to be used in the late stages of rehabilitation into the program, progression is considered after the 3rd week will be added. All athletes with shoulder pain will include in the baseline evaluation at the beginning of the season and all parameters will be followed throughout the season for 8 weeks. All athletes in this group will participate in a total of 24 physiotherapy sessions, 3 days a week, for eight weeks.
Study: NCT04666766

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Microwave scanning of the head
Description: A scan of the head will be performed with a microwave device to ascertain the likelihood of intracranial hemorrhage.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Microwave scanning of the head
Description: A scan of the head will be performed with a microwave device to ascertain the likelihood of intracranial hemorrhage.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Microwave scanning of the head
Description: A scan of the head will be performed with a microwave device to ascertain the likelihood of intracranial hemorrhage.
Study: NCT04679402

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Carbon monoxide 200 ppm in air
Description: Low dose carbon monoxide

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Carbon monoxide 200 ppm in air
Description: Low dose carbon monoxide
Study: NCT04584034

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Salbutamol
Description: Salbutamol will be delivered using a Babyhaler spacer device. Ventolin will be used, brandname for Salbutamol sulfate. Ventolin contains the propellant HFA 134a.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: The placebo will be delivered using a Babyhaler spacer device. The placebo will contain only the propellant HFA 134a.
Study: NCT05009147

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Home-based massage by caregivers for dementia
Description: A total of 40 patients with dementia and their family caregivers will be included and randomly allocated to experiment (n=20) or control group (n=20). The experiment and control group will receive whole body manual massage and placebo intervention (30 minutes once per week for 8 continuous weeks), respectively.
Study: NCT05892068

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tucatinib
Description: Standard dose of 300mg orally twice daily for 4 days prior to surgery (day -4 to 0).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tucatinib
Description: Standard dose of 300mg orally twice daily for 4 days prior to surgery (day -4 to 0).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tucatinib
Description: Standard dose of 300mg orally twice daily for 4 days prior to surgery (day -4 to 0).
Study: NCT04499807

Intervention type: OTHER
Group type: OTHER
Intervention: AFib detection with wearable smart watch
Description: Patients will transmit two rhythm strips every day through both the devices and additional transmission whenever they have symptoms (palpitations, skipped beats, shortness of breath and chest pain). The transmitted rhythm strips are de-identified and analyzed after assigning a unique ID for research purposes.
Study: NCT05518656

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Experimental intervention
Description: Daily lessons received by email to be completed the same day

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Comparison intervention
Description: Daily lessons receive by email to be completed the same day
Study: NCT06248918

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: WATSOCPAP
Description: Participants will receive an supervised and individualized exercise plan, activity tracker, and physical activity coaching program based Social Cognitive Theory. Participants will be administered strengthening and aerobic exercise program, structured and individualized according to the person's individual capacity and needs, under the supervision of a physiotherapist. The activity tracker will provide real-time activity information about daily steps, time spent with MVPA (minutes/day) and sedentary time. The nurse-led physical activity coaching program was planned according to the Social Cognitive Theory (SCT) components such as self-regulation, outcome expectation, social support and perceived environment. The interventions will continue with online and the 12-week program will be completed.
Study: NCT05599009

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: remote ischemic conditioning
Description: Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min re-perfusion. Limb ischemia was induced by inflation of a blood pressure cuff to 200 mmHg. All patients underwent dynamic cerebral autoregulation before treatment, immediately after treatment, 6 hours after treatment and 24 hours after treatment.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: sham remote ischemic conditioning
Description: Remote ischemic conditioning (RIC) is induced by 4 cycles of 5 min of healthy upper limb ischemia followed by 5 min re-perfusion. Limb ischemia was induced by inflation of a blood pressure cuff to 60 mmHg. All patients underwent dynamic cerebral autoregulation before treatment, immediately after treatment, 6 hours after treatment and 24 hours after treatment.
Study: NCT04843033

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SH3809 tablet
Description: Starting dose 2mg,oral administered once daily. If tolerated subsequent cohorts will test increasing doses (4mg,6mg,8mg,10mg,12mg) of SH3809.
Study: NCT06495788

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: High-intensity laser therapy (HILT)
Description: * Pulsed high-intensity laser therapy (HILT) will be applied 3 sessions per week for 8 weeks with pulsed emission (1064 nm), very high peak power (3 kW), a short duration (120-150 ms), and low frequency (10-40 Hz).The probe is fixed vertically at 90° to the most painful points while the patients sit on a chair and wear safety eyewear.~* Conventional treatment ( 3 days per week for 8 weeks).: in the form of~* Hot pad: It will be used over the temporomandibular joint (TMJ) for 5 minutes at the beginning of each session.~* Ultrasound therapy (US): it will be applied over the TMJ with pulsed intensity of 1.0 W/cm2 at a 1MHz frequency for 5 min/session.~* TENS: one electrode is placed over the TMJ and the other just above the mandibular angle. it will be applied with a low frequency of 50 HZ, tolerable intensity for 15 minutes.~* Exercise therapy: anterior, medial and lateral glide of the mandible. Each glide will be done 10-15 repetitions, 5-6 times in a session, 10 minutes as a total.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: placebo high-intensity laser therapy
Description: The same treatment procedure will be applied in the placebo group as in the experimental group, but the laser device is turned off during applications, in addition to the conventional treatment in the form of hot pad, US, TENS, and exercise therapy.
Study: NCT05394662

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Juveena Hydrogel System
Description: Application of a novel hydrogel immediately following the transcervical procedure
Study: NCT06286839

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Cannabidiol (CBD)
Description: Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa L.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Cannabidiol (CBD)
Description: Cannabidiol (CBD), a non-psychoactive component of Cannabis sativa L.
Study: NCT05729633

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Robot mediated upper limb therapy
Description: The OR is classified as a Class A device with the Health Sciences Authority. The OR is capable of both delivering RMIT as well as RMTT. It can provide zero, partial, or full assistance to the patient to complete the movement or task. Its teach-and-follow mode allows a movement to be performed by the therapist, with the device then replaying the movement at either zero, partial, or full assistance, for the patient.~Impairment oriented training will focus on the following movements:~1. Diagonal movement~2. Shoulder abduction~3. Shoulder adduction~4. Shoulder flexion~5. Shoulder extension~6. Elbow flexion~7. Elbow extension~Task-specific training will focus on the following activities:~1. Picking up a cup/glass by the side and drink~2. Brushing hair~3. Cleaning unaffected upper limb (hand to arm)~4. Wiping table~5. Wiping wall~6. Sliding card on table to a designated location~7. Clipping a clothe peg

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Robot mediated upper limb therapy
Description: The OR is classified as a Class A device with the Health Sciences Authority. The OR is capable of both delivering RMIT as well as RMTT. It can provide zero, partial, or full assistance to the patient to complete the movement or task. Its teach-and-follow mode allows a movement to be performed by the therapist, with the device then replaying the movement at either zero, partial, or full assistance, for the patient.~Impairment oriented training will focus on the following movements:~1. Diagonal movement~2. Shoulder abduction~3. Shoulder adduction~4. Shoulder flexion~5. Shoulder extension~6. Elbow flexion~7. Elbow extension~Task-specific training will focus on the following activities:~1. Picking up a cup/glass by the side and drink~2. Brushing hair~3. Cleaning unaffected upper limb (hand to arm)~4. Wiping table~5. Wiping wall~6. Sliding card on table to a designated location~7. Clipping a clothe peg
Study: NCT05147454

Intervention type: OTHER
Intervention: Quantitative Sensory Testing
Description: Non-invasive assessment of Sensory Profile

Intervention type: OTHER
Intervention: Quantitative Sensory Testing
Description: Non-invasive assessment of Sensory Profile
Study: NCT06207825

Intervention type: DIAGNOSTIC_TEST
Intervention: Test images and videos
Description: A set of test images and videos will be collected prospectively from other subjects, according to the eligibility criteria, followed by random allocation of computer-generated sequence.
Study: NCT04744844

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: blastocoel fluid biopsy
Description: In the present study, blastocoel fluid biopsy (BF-biopsy) and collapse will be performed using a microinjection pipette similar to that used to perform ICSI. The pipette will be pushed gently through the zona pellucida and TE, and up to 90% of the BF will be aspirated.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: blastocoel fluid biopsy
Description: In the present study, blastocoel fluid biopsy (BF-biopsy) and collapse will be performed using a microinjection pipette similar to that used to perform ICSI. The pipette will be pushed gently through the zona pellucida and TE, and up to 90% of the BF will be aspirated.
Study: NCT06280469

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Single-Balloon Enteroscopy
Description: The inflated balloon is supposed to fix the intestine to the endoscope system.Pushing the endoscope deeper into the small bowel with the balloon and enteroscope.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Single-Balloon Enteroscopy
Description: The inflated balloon is supposed to fix the intestine to the endoscope system.Pushing the endoscope deeper into the small bowel with the balloon and enteroscope.
Study: NCT04622384

Intervention type: OTHER
Intervention: Dialysis weaning
Description: Dialysis weaning as planned by the attending ICU-physician.
Study: NCT06141915

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aerobic training
Description: patients will be engaged in aerobic training using treadmill three times per week, for 12 weeks. The exercise intensity will be 50-70% of each patient's maximum heart rate. Each exercise session will consist of three phases; five-minutes warming up phase in form of stretching exercises and walking on the treadmill at the slowest speed, 20-minutes conditioning phase in form of walking on the treadmill at 50% of participants' maximum heart rate in the first two weeks then progressed gradually to reach the 70% of maximum heart rate by the 12th weeks, and five-minutes cool down phase that will be constant as warming up phase. During the training, the patient's blood pressure, heart rate, and breathing pattern will be frequently monitored

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aerobic training
Description: patients will be engaged in aerobic training using treadmill three times per week, for 12 weeks. The exercise intensity will be 50-70% of each patient's maximum heart rate. Each exercise session will consist of three phases; five-minutes warming up phase in form of stretching exercises and walking on the treadmill at the slowest speed, 20-minutes conditioning phase in form of walking on the treadmill at 50% of participants' maximum heart rate in the first two weeks then progressed gradually to reach the 70% of maximum heart rate by the 12th weeks, and five-minutes cool down phase that will be constant as warming up phase. During the training, the patient's blood pressure, heart rate, and breathing pattern will be frequently monitored

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: diet protocol
Description: diet protocol
Study: NCT06370143

Intervention type: BEHAVIORAL
Intervention: Questionnaire
Description: The questionnaire on clinical, environmental, lifestyle, and dietary risk factors will be administered

Intervention type: BEHAVIORAL
Intervention: Questionnaire
Description: The questionnaire on clinical, environmental, lifestyle, and dietary risk factors will be administered

Intervention type: BEHAVIORAL
Intervention: Questionnaire
Description: The questionnaire on clinical, environmental, lifestyle, and dietary risk factors will be administered
Study: NCT06480396

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: High-intensity radiological surveillance
Description: The standard approach to surveillance imaging will be contrasted CT (IV and oral contrast) of the chest, abdomen and pelvis. All patients require radiological assessment of the chest, abdomen and pelvis at each surveillance round. Tolerance will be given in the protocol for selected patients where CT is not suitable to receive alternative imaging such as MRI or combination of MRI and CT. Uncontrasted CT imaging is permissible where renal toxicity or allergy from intravenous contrast is of concern. The use of plain radiography is not permitted as an alternative to CT imaging of the chest.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Lower-intensity radiological surveillance
Description: The standard approach to surveillance imaging will be contrasted CT (IV and oral contrast) of the chest, abdomen and pelvis. All patients require radiological assessment of the chest, abdomen and pelvis at each surveillance round. Tolerance will be given in the protocol for selected patients where CT is not suitable to receive alternative imaging such as MRI or combination of MRI and CT. Uncontrasted CT imaging is permissible where renal toxicity or allergy from intravenous contrast is of concern. The use of plain radiography is not permitted as an alternative to CT imaging of the chest.
Study: NCT05367024

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Broccoli soup
Description: Participants will consume one broccoli soup three times a week for one 12-week intervention period as part of their normal diet.
Study: NCT05294237

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Happy program
Description: The Happy program consists of handball specific warm-up components and resistance training components and will be available online.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Happy program
Description: The Happy program consists of handball specific warm-up components and resistance training components and will be available online.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Support
Description: The support consists of a coach workshop at the beginning of the season and the opportunity for additional support for the coaches throughout the season.
Study: NCT05047705

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Distress Tolerance Skills Training
Description: Individuals with TS will receive distress tolerance skill training. Therapeutic skill training will consist of 4 weekly 1-hour sessions. Skill training will occur either in-person or remotely via videoconferencing software. Sessions will focus on building participants' distress tolerance skills with strategies drawn from third-wave CBT.
Study: NCT06152874

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: consumption of glucose solution 1
Description: glucose solution prepared dissolving 55 g of monohydrate glucose powder in 250 mL of water

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: consumption of glucose solution 2
Description: glucose solution prepared dissolving 55 g of monohydrate glucose powder in 250 mL of water

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: consumption of Bread A and oral processing
Description: bread made with 95% durum wheat fine semolina (\< 400 micrometer) + 5% of gluten + 1.2% of yeast + 1% of salt + 59%of water) (portion corresponding to 50 g available carbohydrates) + 250 mL water

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: consumption of Bread B and oral processing
Description: bread made with 80% durum wheat fine semolina (\< 400micrometer) + 20% of gluten+ 1.2% of yeast + 1% of salt + 59%of water (portion corresponding to 50g available carbohydrates) +250 mL water

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: consumption of Bread C and oral processing
Description: bread made with 80% durum wheat coarse semolina (\> 500micrometer)+ 20% of gluten+ 1.2% of yeast + 1% of salt + 59%of water (portion corresponding to 50g available carbohydrates) +250 mL water