TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06116006

Intervention type: OTHER
Group type: OTHER
Intervention: Upper limb pointing movements in 3 experimental conditions
Description: Recording of cerebral hemodynamic with fNIRS during upper limb pointing movements with a robotic device in three conditions: movements with robot assistance, movements without robot assistance and movements with robot resistance. Each subject are recorded during 6 trials for each condition (18 trials). The order is counterbalanced among the subjects.
Study: NCT05602818

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat 300 mg
Description: Administered orally.
Study: NCT06067958

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexmedetomidine
Description: Intranasal administration of dexmedetomidine will be done using MAD Nasal atomization device (Teleflex Medical, 3015 Carrington Mill Blvd, Morrisville, NC 27560, USA). Administration will be given to both nares at a similar volume.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: Intranasal administration of saline 0.9% will be done using MAD Nasal atomization device (Teleflex Medical, 3015 Carrington Mill Blvd, Morrisville, NC 27560, USA). Administration will be given to both nares at a similar volume.
Study: NCT05179109

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Minimally invasive surgery
Description: Minimally invasive surgery for severe deep endometriosis

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Minimally invasive surgery
Description: Minimally invasive surgery for severe deep endometriosis
Study: NCT05458271

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: VCMX
Description: A flap will be raised and VCMX will be placed in order to increase the soft tissue volume

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: CTG
Description: A flap will be raised and a CTG will be harvested from the palate and placed in order to increase the soft tissue volume
Study: NCT06478589

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Adapted Patient Priorities Care (PPC) approach
Description: Step 1 is a PPC facilitation encounter, at which the facilitator will help the participant identify patient priorities, such as clarifying values (what matters most); setting meaningful, specific, and realistic outcome goals; describing healthcare preferences (care that is helpful and/or burdensome) and tradeoffs; and discussing priorities with clinicians. The participant's healthcare priorities are then documented and transmitted to clinicians, in order to facilitate changes in the patient's care plan to align it with his/her priorities. In step 2, the clinician considers patient's priorities and potential healthcare options (options might include starting or stopping treatments; adding or removing medications; ordering more or fewer tests; recommending or removing self-management tasks). In step 3, the clinician discusses care options with the participant, using strategies for aligning care with patient priorities.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Usual Care
Description: Usual care for breast cancer survivorship includes regular visits with the oncology provider and yearly mammograms for surveillance.
Study: NCT05602818

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat 600 mg
Description: Administered orally.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Soticlestat 900 mg
Description: Administered orally.
Study: NCT06478589

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual Care
Description: Usual care for breast cancer survivorship includes regular visits with the oncology provider and yearly mammograms for surveillance.
Study: NCT04132999

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Family-informed intervention
Description: Multiple face-to-face visits, telephone calls and-person visits with the PAP psychologist and team
Study: NCT05602818

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Alprazolam
Description: Administered orally.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered orally.
Study: NCT04132999

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard Clinical Care
Description: Support which is given as part of the standard clinical care for patients who are currently prescribed PAP.
Study: NCT05988619

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Transcranial Magnetic Stimulation
Description: TMS is a noninvasive method of brain stimulation administered by physicians in the UCLA TMS Clinical and Research Service. It is an FDA-approved treatment for Major Depressive Disorder.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transcranial Magnetic Stimulation
Description: TMS is a noninvasive method of brain stimulation administered by physicians in the UCLA TMS Clinical and Research Service. It is an FDA-approved treatment for Major Depressive Disorder.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Internet-Based Cognitive Behavioral Therapy
Description: This Way Up is an internet-based cognitive behavioral therapy (iCBT) for depression and anxiety. Participants learn about depression and anxiety symptoms, as well as behavioral strategies for addressing these symptoms. Participants are provided with homework exercises designed to help them engage in these strategies regularly.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Psychoeducation
Description: Stories of the Mind is an educational program that is freely available through the Public Broadcast Service (PBS). Participants view video testimonials in which individuals describe their personal experiences across a variety of mental health concerns.
Study: NCT05842668

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ESWL Group
Description: Increasing comfort and reducing pain during ESWL
Study: NCT04944836

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clomiphene Citrate
Description: All patients will receive non-labeled pills identical in appearance from our pharmacy, to be taking once every other day. In the study group, these will contain 50 mg of clomiphene citrate. In the control group, these will be placebo. These will be taken every other day for seven months beginning four weeks prior to surgery and extending for six months after surgery. After enrollment patients will be randomized. Patient will be assigned to the 2 groups using a permuted block randomization scheme with blocks of size 2, 4, and 6. Prior to initiation of the study opaque sealed envelopes will be prepared and thoroughly shuffled and then used sequentially during the study. These randomization assignments will be available to the pharmacy in a web-based format or by cards in sealed envelopes. A nonparticipant in the study (the pharmacy at our institution) will administer this process.
Study: NCT04806178

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Bacillus Calmette Guerin
Description: 0.1 ml of lyophilized, live, and attenuated BCG intradermal vaccine, containing between 2 and 8 x 1.000.000 C.F.U in a single dose.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: PLACEBO
Description: 0.1 ml 0.9% saline in the same volume as the BCG vaccine in a single dose.
Study: NCT06245733

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Compassion-Based Education Program Adapted for Adults
Description: Training will be given once a week. This training will last 10 weeks in total.
Study: NCT05931094

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Augmented Reality based games
Description: Games of Wonder Tree Augmented Reality

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional therapy
Description: Traditional therapy based on play activities utilizing blocks, colors, Velcro-based toys.
Study: NCT05142904

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Radiofrequency ablation
Description: Ultrasound-guided radiofrequency ablation of the solitary autonomous thyroid nodule.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Radioactive iodine
Description: I-131 according to standardized doses-calculation.

Intervention type: DRUG
Group type: OTHER
Intervention: Radioactive iodine
Description: I-131 according to local standard.
Study: NCT04897126

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Shexiang Baoxin pill（MUSKARDIA）
Description: On the basis of routine treatment, MUSK Pills were added to 4 capsules / day, 3 times per day until the end of follow-up.

Intervention type: RADIATION
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: On the basis of routine treatment, Placebo were added to 4 capsules / day, 3 times per day until the end of follow-up.
Study: NCT05747157

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metabolically Armed CD19 CAR-T cells
Description: Each subject receive metabolically armed CD19 CAR-T cells by intravenous infusion.
Study: NCT05359289

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Forest therapy training
Description: Participants will experience nature-based interventions including forest hiking, horticultural therapy and green wellness activities for their mental health and physical conditions.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Senior fitness training
Description: The fitness program includes physics fitness of stamina, coordination and aerobic exercise in 12 weeks. Participants will join the senior fitness program including physical fitness, aerobic exercise and exercise prescription during the 12 weeks program.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Board Games
Description: Participants will play board games with each other.
Study: NCT04107961

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Vaccine
Description: Single intramuscular injection into the deltoid region

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Single intramuscular injection into the deltoid region
Study: NCT05003206

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Functional magnetic resonance imaging
Description: Preoperative and postoperative functional magnetic resonance imaging (fMRI) scanning. fMRI is a new neuroimaging method. Its principle is to use magnetic resonance imaging to measure the changes of hemodynamics caused by neuronal activity.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Deep Brain Stimulation
Description: For PD patients treated with DBS, the neurologist will turn off the stimulator before MRI scan
Study: NCT05628012

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Circadian Based Time Restricted Eating
Description: Personalized schedule to restrict eating based on DLMO, approximately \~4h prior to DLMO or sleep onset.
Study: NCT04427241

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cerebrolysin
Description: 30 ml cerebrolysin + 70 ml normal saline, days 4-17, once/day, intravenously

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Control
Description: 100 ml normal saline, days 4-17, once/day, IV
Study: NCT05297162

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: PSMA PET/TRUS (trans-rectal or trans-perineal) fusion biopsy
Description: The prostate profile and ROIs will be drawn on PSMA PET and mpMRI and fused in real time with the TRUS image stack during biopsy. Biopsies, transrectal or transperineal according to lesion site, will be performed with patients in the dorsal lithotomy position, under antibiotic prophylaxis and local anesthesia, using 3D triplane transrectal ultrasound system (BK Medical, Analogic Ultrasound Group, Pro Focus, Transducer 8818, 6/9 MHz).~Biopsy cores will be numbered according to ROI number and topography. Specimens will be processed and evaluated by a genitourinary pathologist. Tumor foci will be quantified and graded according to the ISUP consensus conference on Gleason grading.
Study: NCT06303596

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hippotherapy
Description: Hippotherapy: Hippotherapy in psychiatry is not concerned only about the patient sitting on a horse and the horseback movement influencing the physical condition of the patient and his functional and postural disorders. This therapy is concerned with positive effects on a patient's mental state and use mainly contact with the horse, work with the horse from the ground and riding on horseback. It aims for enjoyment, social communication, and the development of cognitive and executive functions.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard psychiatric treatment
Description: Standard psychiatric treatment: Standard psychiatric treatment includes medication and routine activities provided by the Community Mental Health Center.

Intervention type: OTHER
Group type: OTHER
Intervention: Standard psychiatric treatment
Description: Standard psychiatric treatment: Standard psychiatric treatment includes medication and routine activities provided by the Community Mental Health Center.
Study: NCT05361200

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dynamic high-cadence cycling
Description: Resistance settings will be changed based on entropy of cadence every 3 sessions. Cadence will be set at 80RPM for both groups

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Dynamic high-cadence cycling
Description: Resistance settings will be changed based on entropy of cadence every 3 sessions. Cadence will be set at 80RPM for both groups
Study: NCT05079984

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Graded exposure treatment (GET)
Description: Graded-exposure is a theory driven, individually tailored, and evidenced based behavioral intervention for individuals with chronic pain targeting pain-related impairment by exposing patients to previously feared and avoided activities.
Study: NCT05277987

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HEC-016(0.5×10^6 CAR-T Cells)
Description: The initial dose is set to 0.5 × 10\^6 car-t cells / kg, and 3 \~ 6 subjects are expected to be included in the dose group. DLT was observed within 28 days after cell infusion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HEC-016(0.5×10^6.5 CAR-T Cells)
Description: The Second dose is set 0.5 × 10\^6.5 car-t cells / kg, and 3 \~ 6 subjects are expected to be included in the dose group.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HEC-016(0.5×10^7 CAR-T Cells)
Description: The Third dose is set 0.5 × 10\^7 car-t cells / kg, and 3 \~ 6 subjects are expected to be included in the dose group.
Study: NCT06033924

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Walking Program: Internet-based
Description: Internet pages allow participants to see step-count goals, progress over time and access to walking tips for 12 weeks. Among participants who do not increase their step counts (\>15%), these non-responders will be rerandomized to received the combination of internet and telehealth or either along for an additional 12-weeks (total intervention time is 24-weeks). A follow-up phase of 12-weeks will be completed for a total participant duration of 36 weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Walking Program: Telehealth-based
Description: Telehealth sessions allow participants review step-count goals, progress over time and access to walking tips with the study coordinator for 12 weeks. Among participants who do not increase their step counts (\>15%), these non-responders will be rerandomized to received the combination of internet and telehealth or either along for an additional 12-weeks (total intervention time is 24-weeks). A follow-up phase of 12-weeks will be completed for a total participant duration of 36 weeks.
Study: NCT06033352

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: KTP laser
Description: Treatment with KTP 532 nm laser. Laser fluence depends on erythema intensity and ranges from 7.0 J/cm2 to 11 J/cm2 with a 4-11 mm spot size and 8-12 ms pulse duration.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: KTP laser
Description: Treatment with KTP 532 nm laser. Laser fluence depends on erythema intensity and ranges from 7.0 J/cm2 to 11 J/cm2 with a 4-11 mm spot size and 8-12 ms pulse duration.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ivermectin 1% cream
Description: Application of ivermectin 1% cream 1x/day. Interruption for 4 days in case of irritation/redness.
Study: NCT06335225

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Precise nutritional intervention
Description: Diabetic precision nutrition prescription based on the results of nutrigenomics.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Conventional nutritional intervention
Description: Conventional diabetes nutrition prescription.
Study: NCT04827992

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Medical Marijuana
Description: Patients in this group can choose what type, how much, and when to use medical marijuana to use.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Prescription Opioid Taper Support (POTS)
Description: Prescription Opioid Taper Support (POTS), a manualized behavioral prescription opioid taper support intervention developed by consultant, will be offered weekly to all participants to support behavioral self-management of pain and structured, voluntary taper of COT dose.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Prescription Opioid Taper Support (POTS)
Description: Prescription Opioid Taper Support (POTS), a manualized behavioral prescription opioid taper support intervention developed by consultant, will be offered weekly to all participants to support behavioral self-management of pain and structured, voluntary taper of COT dose.
Study: NCT06174129

Intervention type: OTHER
Intervention: Routine examinations
Description: Electrocardiography and clinical parameters examinations, including age, sex, body-mass index, underlying medical conditions, blood pressure, heart rate, type 2 diabetes duration, laboratory values, and medications

Intervention type: OTHER
Intervention: Routine examinations
Description: Electrocardiography and clinical parameters examinations, including age, sex, body-mass index, underlying medical conditions, blood pressure, heart rate, type 2 diabetes duration, laboratory values, and medications
Study: NCT04891133

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib
Description: 4 mg baricitinib (2 tablets of 2 mg) once daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 4 mg placebo (2 tablets of 2 mg) once daily
Study: NCT05761379

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Photobiomodualtion Therapy
Description: low lever light therapy with laser semi-conductor at wavelength of 650nm

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Photobiomodualtion Therapy
Description: low lever light therapy with laser semi-conductor at wavelength of 650nm

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Single vision spectacles for correction myopia
Description: Provide the distance best corrected vision acuity of refractive error of myopia for all the groups

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Single vision spectacles for correction myopia
Description: Provide the distance best corrected vision acuity of refractive error of myopia for all the groups

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Single vision spectacles for correction myopia
Description: Provide the distance best corrected vision acuity of refractive error of myopia for all the groups
Study: NCT05010928

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: mouthwash with tea
Description: Using tea as a base, supplemented with licorice to make mouthwash to relieve stomatitis.
Study: NCT04944836

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rotator Cuff Repair
Description: The operative protocol will be standardized in all patients. Both the operative protocol and post-operative rehabilitation protocol will be per our standard of care, without alteration. An arthroscopic approach will be used. In all cases a double-row rotator cuff repair using triple-loaded anchor(s) on the medial row will be used. Post-operatively all patients will be placed in a sling for six weeks. Active range of motion exercises will begin at six weeks post-operatively and strengthening will be delayed until 12 weeks post-operatively. In all phases of care our peri-operative and post-operative protocol for study patients will be similar to our current clinical practice to ensure generalizability.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Rotator Cuff Repair
Description: The operative protocol will be standardized in all patients. Both the operative protocol and post-operative rehabilitation protocol will be per our standard of care, without alteration. An arthroscopic approach will be used. In all cases a double-row rotator cuff repair using triple-loaded anchor(s) on the medial row will be used. Post-operatively all patients will be placed in a sling for six weeks. Active range of motion exercises will begin at six weeks post-operatively and strengthening will be delayed until 12 weeks post-operatively. In all phases of care our peri-operative and post-operative protocol for study patients will be similar to our current clinical practice to ensure generalizability.
Study: NCT05700279

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Stellate Ganglion Block
Description: Stellate Ganglion Block (SGB) procedure involves an injection of a local anesthetic (0.5% ropivacaine) around the stellate ganglion (a bundle of nerves located at the base of the neck) to block the transmission of pain signals. The SGB injection is administered by an anesthesiologist.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Processing Therapy
Description: Cognitive Processing Therapy (CPT) is a form of trauma-based talk therapy that will be conducted by clinical therapists. CPT can help people identify and challenge unhelpful trauma-related beliefs about themselves, others, and the world.
Study: NCT05588466

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: CDS Alone
Description: The practices in the 'CDS alone' arm will receive an updated CDS for HTN management.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: CDS plus practice facilitation
Description: The practices in the 'CDS plus practice facilitation' arm will receive an updated CDS for HTN management plus practice facilitation to support the adoption of the CDS.