TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05531604

Intervention type: BEHAVIORAL
Intervention: appetitive conditioning
Description: The investigators will examine acquisition and extinction of learned associations to positively-valenced, socially rewarding yet symptom-neutral infant laughter sounds in an appetitive conditioning paradigm. The investigators will also examine spontaneous recovery of this association 24 hours later when re-presented with these cues, and the reinstatement of this association when re-exposed to infant laughter.

Intervention type: BEHAVIORAL
Intervention: appetitive conditioning
Description: The investigators will examine acquisition and extinction of learned associations to positively-valenced, socially rewarding yet symptom-neutral infant laughter sounds in an appetitive conditioning paradigm. The investigators will also examine spontaneous recovery of this association 24 hours later when re-presented with these cues, and the reinstatement of this association when re-exposed to infant laughter.

Intervention type: BEHAVIORAL
Intervention: appetitive conditioning
Description: The investigators will examine acquisition and extinction of learned associations to positively-valenced, socially rewarding yet symptom-neutral infant laughter sounds in an appetitive conditioning paradigm. The investigators will also examine spontaneous recovery of this association 24 hours later when re-presented with these cues, and the reinstatement of this association when re-exposed to infant laughter.
Study: NCT05607433

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: cook ®Airway Exchanger Catheter
Description: A tube exchanger is a small calibre , flexible tube used to guide endotracheal intubation through a supraglottic device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: cook ®Airway Exchanger Catheter
Description: A tube exchanger is a small calibre , flexible tube used to guide endotracheal intubation through a supraglottic device.
Study: NCT06535802

Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-interventional study

Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-interventional study

Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-interventional study

Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-interventional study

Intervention type: OTHER
Intervention: Non-Interventional Study
Description: Non-interventional study
Study: NCT06535464

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Hypotension Prediction Index
Description: Fluid management guided by Hypotension Prediction Index

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: No Hypotension Prediction Index
Description: Fluid management not guided by Hypotension Prediction Index
Study: NCT04863885

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nivolumab
Description: Participants will receive Nivoumab 1mg/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nivolumab
Description: Participants will receive Nivoumab 1mg/kg
Study: NCT05942976

Intervention type: OTHER
Intervention: ULTRASOUND
Description: 10 enthesis areas will be evaluated in 20 minutes with ultrasound.

Intervention type: OTHER
Intervention: ULTRASOUND
Description: 10 enthesis areas will be evaluated in 20 minutes with ultrasound.

Intervention type: OTHER
Intervention: ULTRASOUND
Description: 10 enthesis areas will be evaluated in 20 minutes with ultrasound.
Study: NCT05290493

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: NB-001
Description: NB-001 is a non-stimulant activator of multiple metabotropic glutamate receptors (mGluRs).

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching, inactive placebo
Study: NCT05907655

Intervention type: DRUG
Intervention: Nitroglycerin 0.3 MG
Description: Sublingual nitroglycerin will be used to provoke spontaneous-like migraine attacks in migraine patients. A dose of 0.9 mg of sublingual nitroglycerin will be used. The same dose will be administrated to controls.

Intervention type: DRUG
Intervention: Nitroglycerin 0.3 MG
Description: Sublingual nitroglycerin will be used to provoke spontaneous-like migraine attacks in migraine patients. A dose of 0.9 mg of sublingual nitroglycerin will be used. The same dose will be administrated to controls.

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: The following brain MRI sequences will be acquired before and after nitroglycerin administration: fluid attenuated inversion recovery (FLAIR), 3D T1-weighted inversion recovery prepared gradient echo, diffusion weighted sequence and 3D susceptibility weighted images.

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: The following brain MRI sequences will be acquired before and after nitroglycerin administration: fluid attenuated inversion recovery (FLAIR), 3D T1-weighted inversion recovery prepared gradient echo, diffusion weighted sequence and 3D susceptibility weighted images.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sampling
Description: Plasma levels of neuropeptides involed in migraine will be measured using commercially available enzyme-linked immune-sorbent assay (ELISA) kits. All ELISA will be performed by the same experienced technician who will be blinded for the clinical diagnosis.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sampling
Description: Plasma levels of neuropeptides involed in migraine will be measured using commercially available enzyme-linked immune-sorbent assay (ELISA) kits. All ELISA will be performed by the same experienced technician who will be blinded for the clinical diagnosis.

Intervention type: DEVICE
Intervention: Sleep profiler
Description: Sleep architecture will be investigated using the Sleep Profiler. Sleep Profiler is medical device with CE mark which is produced by Advanced Brain Monitoring and distributed throughout Italy exclusively by Medigas. Sleep staging will be automatically performed for 30-second epochs throughout a dedicated software and a standardized and validated procedure. Frontopolar EEG signal waveforms will be visually inspected to confirm the accuracy of the auto-staging.

Intervention type: DEVICE
Intervention: Sleep profiler
Description: Sleep architecture will be investigated using the Sleep Profiler. Sleep Profiler is medical device with CE mark which is produced by Advanced Brain Monitoring and distributed throughout Italy exclusively by Medigas. Sleep staging will be automatically performed for 30-second epochs throughout a dedicated software and a standardized and validated procedure. Frontopolar EEG signal waveforms will be visually inspected to confirm the accuracy of the auto-staging.
Study: NCT04344873

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo injection at day one and day fourteen.
Study: NCT05622500

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Deep venous stenting
Description: Endovascular reconstruction encompasses balloon venoplasty and venous stenting. A dedicated venous stent will be used, the brand of which the individual interventionist will decide.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Best medical therapy
Description: Compression stockings encompass a range of therapies used to provide an externally applied graduated-pressure up the length of the limb aiming to improve venous function and decrease lower limb swelling. Compression stockings can be classified by size and grade, i.e. the pressure the stockings applies to the limb. For the purpose of this trial Class II and Class III graduated compression stockings should be used, with the aim of providing Class III if tolerated. Antithrombotic agents include, but are not limited to: warfarin (titrated to international normalised ratio, INR), apixaban, rivaroxaban, aspirin, and clopidogrel.

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Best medical therapy
Description: Compression stockings encompass a range of therapies used to provide an externally applied graduated-pressure up the length of the limb aiming to improve venous function and decrease lower limb swelling. Compression stockings can be classified by size and grade, i.e. the pressure the stockings applies to the limb. For the purpose of this trial Class II and Class III graduated compression stockings should be used, with the aim of providing Class III if tolerated. Antithrombotic agents include, but are not limited to: warfarin (titrated to international normalised ratio, INR), apixaban, rivaroxaban, aspirin, and clopidogrel.
Study: NCT05122663

Intervention type: BEHAVIORAL
Intervention: Vestibular Rehabilitation
Description: Vestibular Rehabilitation refers to the specific interventions that physical therapists provide to patients with dizziness and vertigo symptoms. These interventions can involve repositioning maneuvers, habituation exercises, gaze stabilization, and/or balance training exercises, depending on the specific etiology of dizziness and vertigo per an established clinical protocol utilizing a patient's history and exam findings. Physical therapists instruct patients in how to perform these exercises at home and provide instructions and referral for patients to follow-up with an outpatient physical therapist for further care.

Intervention type: OTHER
Intervention: Usual Care
Description: Usual Care refers to any combination of diagnostic testing, medications, and patient education or counseling provided by a patient's treating ED physician.
Study: NCT05951738

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Blood and saliva collection
Description: Blood and saliva samples from pregnant women; saliva samples from babies.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Blood and saliva collection
Description: Blood and saliva samples from pregnant women; saliva samples from babies.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Blood and saliva collection
Description: Blood and saliva samples from pregnant women; saliva samples from babies.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Psychometric scales
Description: A battery of psychometric scales and questionnaires.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Psychometric scales
Description: A battery of psychometric scales and questionnaires.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Psychometric scales
Description: A battery of psychometric scales and questionnaires.
Study: NCT04344873

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Abatacept 10 mg/kg
Description: Abatacept injection at day twenty eight and day forty two.
Study: NCT05168293

Intervention type: OTHER
Intervention: Detection of HBV-DNA in Peripheral Blood Mononuclear cells
Description: Detection of HBV-DNA level in Peripheral Blood mononuclear cells
Study: NCT05951738

Intervention type: OTHER
Group type: OTHER
Intervention: Smartphone app
Description: A smartphone application has been developed in the context of the study as a potential preventive and screening strategy.
Study: NCT06422481

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fluid administration
Description: Patients will receive fluid administration (500 mL of saline over 30 minutes). The indication of fluid administration will be left to the discretion of the attending physician.
Study: NCT06422481

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Norepinephrine administration or increase in norepinephrine dosage
Description: Patients will receive norepinephrine or norepinephrine dosage will be increased if necessary to achieve the appropriate mean arterial pressure level. The indication of norepinephrine administration or increase in norepinephrine dosage will be left to the discretion of the attending physician.
Study: NCT05532007

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Peanuts
Description: 2-3 ounces of peanuts to replace 20% of total daily energy intake

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Habitual Diet
Description: continue with habitual diet and abstain from eating peanuts
Study: NCT06494397

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: VHX-896 and iloperidone
Description: oral tablet

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iloperidone and VHX-896
Description: oral tablet
Study: NCT05531331

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: At home education via video conferencing
Description: Educational booklets are given according to the type of stoma. The individual with the stoma was told that the researcher was always reachable by phone and could communicate if he had any problems. The individuals with stoma in the experimental group received the training of the company representative that sells stoma materials, which is routinely given in the hospital. After discharge, training was given by the researcher via video conference in a total of four interviews. The first interview was done on the 5th day after discharge, the second on the 10th day, the third on the 15th day, and the fourth on the 2nd month. A post-test was conducted at the end of the 4th training interview, which was administered via video conferencing.
Study: NCT06198647

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tui-na massage
Description: Using Tui-na massage for the back muscles

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: positional release technique
Description: using positional release manual technique to relax the back muscles
Study: NCT06083454

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab
Description: Given intravenous (IV) infusion as monotherapy or in combination with pharmacological ascorbate

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab
Description: Given intravenous (IV) infusion as monotherapy or in combination with pharmacological ascorbate

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pharmacological ascorbate
Description: Given intravenously in combination with Durvalumab

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Surgery (SOC)
Description: Surgery SOC
Study: NCT04892589

Intervention type: OTHER
Intervention: Proprioceptive thumb exercises.
Description: Exercises for recognition of thumb position and thumb force sense.
Study: NCT06473714

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: tDCS
Description: Transcranial direct current stimulation of the dorsolateral prefrontal cortex will be made at 1,5mA

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: SHAM
Description: Transcranial direct current stimulation of the dorsolateral prefrontal cortex will not be made. The electrodes are placed on the skull and a slight but non-continuous intensity is applied.
Study: NCT06377319

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiac Output Response to Stress (CORS) test
Description: Cardiac Output Response to Stress (CORS) is a novel, non-invasive, easy-to-use test developed by the Newcastle and Coventry Universities. CORS test measures heart function (cardiac output) at rest and in response to short step-exercise using validated electrical signal processing bioreactance technology, similar to an ECG.

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiac Output Response to Stress (CORS) test
Description: Cardiac Output Response to Stress (CORS) is a novel, non-invasive, easy-to-use test developed by the Newcastle and Coventry Universities. CORS test measures heart function (cardiac output) at rest and in response to short step-exercise using validated electrical signal processing bioreactance technology, similar to an ECG.
Study: NCT05996120

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Hypothermic Cardiopulmonary Bypass
Description: Mild hypothermia (between 32 - 35 °C) during cardiopulmonary bypass

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Normothermic Cardiopulmonary Bypass
Description: Normothermia (active maintenance of temperature between 36.5 °C to 37.5°C; no active cooling below 36.5 °C) during cardiopulmonary bypass
Study: NCT06312059

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Advance Infant Formula Powder
Description: Sole source infant nutrition for the control arm.
Study: NCT06450158

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Robot (Amadeo)-assisted Training
Description: Amadeo® is an FDA Class I Exempt hand/finger robot that has the capacity to precisely measure hand/finger functions.~To use Amadeo, a participant will be seated in a chair. The height of the robot arm support will be adjusted to achieve a comfortable position for the participant. One of the participant's arms will be will be placed on the robot arm support. Magnetic finger tips will then be attached to fingers and thumb. After this, fingers and thumb will be connected to the robot finger sliders. To use Amadeo, the movement range and maximal force of each finger will be configured according to the finger's capability. The following four types of function assessments will be performed with Amadeo: Force, range of motion, tone, and spasticity. Each session will last approximately one hour.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Robot (Amadeo)-assisted Training
Description: Amadeo® is an FDA Class I Exempt hand/finger robot that has the capacity to precisely measure hand/finger functions.~To use Amadeo, a participant will be seated in a chair. The height of the robot arm support will be adjusted to achieve a comfortable position for the participant. One of the participant's arms will be will be placed on the robot arm support. Magnetic finger tips will then be attached to fingers and thumb. After this, fingers and thumb will be connected to the robot finger sliders. To use Amadeo, the movement range and maximal force of each finger will be configured according to the finger's capability. The following four types of function assessments will be performed with Amadeo: Force, range of motion, tone, and spasticity. Each session will last approximately one hour.
Study: NCT06201663

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Romiplostim
Description: Weekly subcutaneous injections
Study: NCT06180746

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Knowledge mobilization to facilitate the structuring of health mediation
Description: The ECEMSo intervention involves knowledge mobilization to facilitate the structuring of health mediation throughout French territory, and the development of a co-designed effective action plan to facilitate cancer screening uptake by people living in informal housing.~The action plan will, consider territorial specificities at the regional level. The ECEMSo project team will organize a seminar and three workshops. The aim of the seminar and workshops is to mobilize knowledge to facilitate i) the structuring of health mediation in the regions, and ii) the development of an action plan with health mediators and other stakeholders to foster organized cancer screenings uptake by underserved people. This action plan must match with the needs of people living in informal housing, and must be coordinated, suitable and feasible to implement, in terms of knowledge about people living in informal housing specificities and specific local collaborations
Study: NCT05328674

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Arthroscopic reconstruction of cartilage defects in the knee joint with the use of autogenous cartilage transplant with PRP GF (platelet plasma with growth factor)
Description: Arthroscopic reconstruction of cartilage defects in the knee joint using an autogenous PRP GF cartilage transplant.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Arthroscopic reconstruction of the cartilage defects of the knee joint using the microfracture method
Description: Arthroscopic reconstruction of the cartilage defects of the knee joint using the microfracture method.
Study: NCT06112548

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: primary unilateral TKA
Description: Primary unilateral total knee arthroplasty with cruciate scarifying cemented DePuy Synthes PFC Sigma prosthesis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: primary unilateral TKA
Description: Primary unilateral total knee arthroplasty with cruciate scarifying cemented DePuy Synthes PFC Sigma prosthesis.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacain
Description: low body weight (0.50%, 20cc) intraoperative periarticular injection
Study: NCT05951738

Intervention type: OTHER
Group type: OTHER
Intervention: Smartphone app
Description: A smartphone application has been developed in the context of the study as a potential preventive and screening strategy.

Intervention type: OTHER
Group type: OTHER
Intervention: Smartphone app
Description: A smartphone application has been developed in the context of the study as a potential preventive and screening strategy.
Study: NCT06112548

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ketorolac
Description: 1ml of 30mg/ml ketorolac intraoperative periarticular injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: epinephrine
Description: 0.5ml Adrenaline 1mg/ml intraoperative periarticular injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paracetamol
Description: IV Paracetamol \[Ofirmev\] introduced every 6 hours after surgery

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketorolac
Description: IV Ketorolac {Toradol} introduced every 12 hours after surgery.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tramadol
Description: IV Tramadol \[Ultram\] introduced when needed after surgery

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tramadol
Description: IV Tramadol \[Ultram\] introduced when needed after surgery
Study: NCT04864418

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AST-021p
Description: 3 priming immunization (2weeks x3) in 4 cohort groups (1.2mg, 2.4mg, 3.6mg and 4.8mg AST-021p) if possible, 3 boosting immunization (4weeks x 3) in cohort groups after priming immunization
Study: NCT05351021

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: cidophage 850 gm twice daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo twice daily for treatment period
Study: NCT06312059

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kendamil Cow milk test product
Description: Sole source infant nutrition for the cow milk test arm.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kendamil goat milk test product
Description: Sole source infant nutrition for the goat milk test arm.
Study: NCT06168344

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Web-Based Education Program
Description: This study was assessed the impact of a web-based education program provided to mothers of infants with congenital heart diseases on their quality of life and self-efficacy levels
Study: NCT04849273

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TPX-0131
Description: Oral TPX-0131 tablets