TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05372913

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Woebot for Adolescents (W-GenZD) Mobile Application
Description: Woebot for Adolescents (W-GenZD) is a mobile application program that delivers evidence-based therapy for the symptoms of mild-moderate depression and anxiety in adolescents in brief conversations with a fully automated relational agent called Woebot. It is a brief, self-guided 4 week-intervention that draws from cognitive behavioral therapy (CBT), interpersonal psychotherapy for adolescents (IPT-A), and elements of dialectical behavior therapy (DBT), depending on the presenting situation, to help the adolescent develop emotion regulation skills in the context of their everyday life. In this way, the mobile application is designed to be targeted, relevant, and integrated into the lived experience of adolescents, capable of delivering the appropriate technique for the problem at hand, at the time of need.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CBT-Lite Teletherapy Group
Description: The CBT-Lite teletherapy group is a brief, 4-week intervention held once weekly for an hour, and limited to those triaged into the Children's Hospital of the King's Daughters low-intensity track and participating in this protocol. An assigned study clinician will facilitate each teletherapy group with approximately 10 adolescents in each session. Each group begins with orientation and reviewing group rules, individual check-ins with each participant (rating stress level and hopefulness), followed by a guided mindfulness moment. Sessions are designed to draw from elements of cognitive behavioral therapy (CBT) and the 4 topics include: building a coping tool box, accepting your feelings, challenging negative thoughts, and problem solving.
Study: NCT05355597

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Exparel Injectable Product
Description: Both drugs have same desired effect. Will be injected intra-operatively while subjects are under anesthesia to alleviate significant post-operative pain.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Multi-Drug Cocktail (Ropivicaine, Epinephrine, Ketolorac, Clonidine)
Description: Same desired effect as Exparel but different mechanism of action. Will be injected intra-operatively while subjects are under anesthesia to alleviate significant post-operative pain.
Study: NCT05448677

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ezurpimtrostat
Description: Patients in the experimental arm will be instructed to take their assigned oral dose every day.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Atezolizumab
Description: Atezolizumab will be administered by IV infusion at a fixed dose of 1200 mg on Day 1 of each 21-days cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atezolizumab
Description: Atezolizumab will be administered by IV infusion at a fixed dose of 1200 mg on Day 1 of each 21-days cycle

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bevacizumab
Description: Bevacizumab will be administered by IV infusion at a dose of 15 mg/kg on Day 1 of each 21-day cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Bevacizumab will be administered by IV infusion at a dose of 15 mg/kg on Day 1 of each 21-day cycle.
Study: NCT06027840

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Varenicline
Description: Varenicline prescription will follow the standard induction period: varenicline 0.5 mg once per day for Days 1-3, varenicline 0.5 mg twice per day for Days 4-7, then varenicline 1 mg twice per day (when varenicline reaches peak efficacy for tobacco cessation). Participants will remain on varenicline for 12 weeks total. Dose adjustments (e.g., reduction to 0.5 mg twice per day if 1 mg is not well tolerated) will be allowed at the discretion of the clinical pharmacist/APRN/physician.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Varenicline
Description: Varenicline prescription will follow the standard induction period: varenicline 0.5 mg once per day for Days 1-3, varenicline 0.5 mg twice per day for Days 4-7, then varenicline 1 mg twice per day (when varenicline reaches peak efficacy for tobacco cessation). Participants will remain on varenicline for 12 weeks total. Dose adjustments (e.g., reduction to 0.5 mg twice per day if 1 mg is not well tolerated) will be allowed at the discretion of the clinical pharmacist/APRN/physician.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Counseling
Description: Tobacco Treatment Service clinicians will deliver weekly counseling sessions, monitor participants for adverse events, and record participants' weekly cigarette and e-cigarette use. At the first counseling session clinicians will review medication proper use instructions, and potential side effects and strategies to address them at the first counseling session. Study medication refills will be distributed at 4-week intervals. Sessions will focus on quit plan preparation, supportive and practical cessation counseling, resetting quit dates, and relapse prevention.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Counseling
Description: Tobacco Treatment Service clinicians will deliver weekly counseling sessions, monitor participants for adverse events, and record participants' weekly cigarette and e-cigarette use. At the first counseling session clinicians will review medication proper use instructions, and potential side effects and strategies to address them at the first counseling session. Study medication refills will be distributed at 4-week intervals. Sessions will focus on quit plan preparation, supportive and practical cessation counseling, resetting quit dates, and relapse prevention.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Guided Self-Change Booklets
Description: The booklet includes information on how to reduce and quit both cigarettes and e-cigarettes on their own, how to prevent relapse, how to set a quit date, and how to enroll in text-based support resources.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Guided Self-Change Booklets
Description: The booklet includes information on how to reduce and quit both cigarettes and e-cigarettes on their own, how to prevent relapse, how to set a quit date, and how to enroll in text-based support resources.
Study: NCT06161818

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FLOT-CROSS or CROSS-FLOT
Description: Randomization between TNT FLOT-CROSS and TNT CROSS-FLOT

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FLOT-CROSS or CROSS-FLOT
Description: Randomization between TNT FLOT-CROSS and TNT CROSS-FLOT
Study: NCT05286086

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: prehabilitation
Description: Control of the physical, nutritional and psychological preparation of the patient who will undergo rectal cancer surgery

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: prehabilitation
Description: Control of the physical, nutritional and psychological preparation of the patient who will undergo rectal cancer surgery
Study: NCT05726552

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Laughter therapy
Description: Laughter therapy will be applied for 50 minutes, 12 sessions, 3 days a week. The therapy, which starts with the stimulation of the acupuncture points in the palm and acquaintance with hand clapping for an average of 10 minutes, continues with deep breathing and breathing exercises that include diaphragmatic breathing. The childish games section, which is played to reveal and trigger simulated laughter, is the section where laughter starts as if and turns into reality.~The last part is the part where the group makes eye contact for no reason and for no reason, and laughs for at least 3 minutes unconditionally. In the last part, wish meditation and relaxation sessions are performed.
Study: NCT04232800

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Riboflavin
Description: The intervention will consist of 100mg riboflavin (vitamin B2) given in three time daily dosing.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: An inert, standard placebo in identical capsules to primary intervention.
Study: NCT05193500

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Addressed Speech
Description: New words are introduced directly to the child by an experimenter.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Overheard Speech
Description: New words are introduced with the child as a bystander rather directly taught.
Study: NCT01181583

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tailored Internet-delivered CBT
Description: This intervention contains 8-10 text-based self-help modules in which 4 modules are fixed (the first three and the last) and the rest are prescribed following the diagnostic telephone interview. These modules contain material on panic disorder, social phobia, stress management, assertiveness training, concentration, relaxation among other things.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Non-tailored Internet-delivered CBT
Description: Specific text-based self-help for depression, which has previously been tested in three previous randomized trials. Anxiety symptoms will not be covered, but insomnia is included as a module together with advice on health.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Online discussion group
Description: Participants take part of an online discussion group which are monitored daily. New discussion topics on depression are introduced every week.
Study: NCT06047613

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Blood samples
Description: Blood samples will be collected at both visit between 8:30 a.m. and 10 a.m. and fasting from midnight.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Blood samples
Description: Blood samples will be collected at both visit between 8:30 a.m. and 10 a.m. and fasting from midnight.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood samples
Description: Blood samples will be collected at both visit between 8:30 a.m. and 10 a.m. and fasting from midnight.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Hetero-questionnaires and auto-questionnaires
Description: Questionnaires will be administrated at both visits to assess the suicide spectrum, the depression level and some personality traits.~Heteroquestionnaires will be administrated during a clinical interview (1h) conducted by a psychiatrist or psychologist. Autoquestionnaires (45 min) will be completed by the participant himself.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Hetero-questionnaires and auto-questionnaires
Description: Questionnaires will be administrated at both visits to assess the suicide spectrum, the depression level and some personality traits.~Heteroquestionnaires will be administrated during a clinical interview (1h) conducted by a psychiatrist or psychologist. Autoquestionnaires (45 min) will be completed by the participant himself.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hetero-questionnaires and auto-questionnaires
Description: Questionnaires will be administrated at both visits to assess the suicide spectrum, the depression level and some personality traits.~Heteroquestionnaires will be administrated during a clinical interview (1h) conducted by a psychiatrist or psychologist. Autoquestionnaires (45 min) will be completed by the participant himself.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Magnetic Resonance Imaging (MRI)
Description: MRI will be processed (at both visits for patients and at inclusion visit for healthy controls) to study between groups white matter microstructure and brain functional connectivity networks

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Magnetic Resonance Imaging (MRI)
Description: MRI will be processed (at both visits for patients and at inclusion visit for healthy controls) to study between groups white matter microstructure and brain functional connectivity networks

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging (MRI)
Description: MRI will be processed (at both visits for patients and at inclusion visit for healthy controls) to study between groups white matter microstructure and brain functional connectivity networks
Study: NCT05286008

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Normal saline
Description: Before the induction of anesthesia, normal saline is used for bilateral transversus abdominis plane block in a volume of 20 mL of each side

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ropivacaine at high concentration
Description: Before the induction of anesthesia,0.375% ropivacaine is used for bilateral transversus abdominis plane block in a volume of 20 mL of each side

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ropivacaine and dexamethasone
Description: Before the induction of anesthesia, 0.375% Ropivacaine and 5.0mg dexamethasone are used for bilateral transversus abdominis plane block in a volume of 20 mL of each side
Study: NCT06479226

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: cetylpyridinium chloride (0.075%) and zinc alcohol free mouthwash
Description: mouthrinse
Study: NCT05985083

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IMM47
Description: IMM47 is humanized mAb targeting CD24 to be administered via intravenous infusion every 2 weeks in 28-day treatment cycles.
Study: NCT06400264

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: Undergo biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT scan

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Echocardiography
Description: Undergo ECHO

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Nivolumab
Description: Given IV

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Relatlimab
Description: Given IV
Study: NCT06339814

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol
Description: An Eye Movement Desensitization and Reprocessing psychotherapist will hold the Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol sessions, dedicated to psychoeducation, imagery exercises, stabilization techniques and the reprocessing of traumatic events. The Eye Movement Desensitization and Reprocessing Integrative Group Treatment Protocol will be composed of 4 sessions of 120 minutes each.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Treatment As Usual
Description: Treatment As Usual condition will receive only standard support.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Treatment As Usual
Description: Treatment As Usual condition will receive only standard support.
Study: NCT04825834

Intervention type: OTHER
Intervention: Blood Sample Collection
Description: Subjects enrolled in the DELFI-L101 will have blood specimens collected (\~40 mL) at enrollment.

Intervention type: OTHER
Intervention: Blood Sample Collection
Description: Subjects enrolled in the DELFI-L101 will have blood specimens collected (\~40 mL) at enrollment.

Intervention type: OTHER
Intervention: Blood Sample Collection
Description: Subjects enrolled in the DELFI-L101 will have blood specimens collected (\~40 mL) at enrollment.
Study: NCT05823805

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Community Health Worker
Description: Physicians will work with a Community Health Worker (CHW) to review the data presented in their Quality Improvement reports, and triage patients for proactive outreach (e.g. No action necessary, Call patient to check-in, Arrange BP, weight and labs, Book for phone appointment, Book for in-person appointment).
Study: NCT05598138

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Biological Collection
Description: A blood sample (10 ml) will be taken for each patient included in the study.
Study: NCT06042023

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Lifesignals Wearable Sensor
Description: The participants will wear the patch for 3-5 days and be provided with the mobile device, which records data transmitted wirelessly directly from the biosensor patch. During the monitoring period, participants can continue their normal activities.~Remote monitoring will be undertaken using the CE-marked LifeSignals wearable biosensor. The biosensor communicates with a commercially available mobile device, which relays data to a secure Cloud server (GDPR compliant data transfer).~Participants will subsequently undergo their planned surgery in the usual way. Data captured from the remote monitoring will not be used or made accessible to inform decisions about clinical care.~There will be no clinical intervention from the researchers if abnormalities in vital signs are picked up by the monitoring patch, as all data will be analysed retrospectively after the participant's operation. Any clinical concerns about the device that arise will be reported to the relevant clinical team.
Study: NCT06266468

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nutricity
Description: Nutricity is a bilingual (English/Spanish) mobile website supplemented by an automated text-messaging system.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Nutricity
Description: Nutricity is a bilingual (English/Spanish) mobile website supplemented by an automated text-messaging system.
Study: NCT06215625

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Robot-assisted therapy
Description: The TIGER system provides assistance for activities of daily living. Continuous passive mode of TIGER system provides passive range of motion as warm-up. Functional mode TIGER system provides functional training.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Robot-assisted therapy
Description: The TIGER system provides assistance for activities of daily living. Continuous passive mode of TIGER system provides passive range of motion as warm-up. Functional mode TIGER system provides functional training.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Task-oriented training
Description: The TOT group will practice sensorimotor techniques for warming up, and then they will practice various functional tasks based on task-oriented approach.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Task-oriented training
Description: The TOT group will practice sensorimotor techniques for warming up, and then they will practice various functional tasks based on task-oriented approach.
Study: NCT05052749

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High Intensity Resistance Training (HIRT)
Description: High Intensity Resistance Exercises Supervised High Intensity Resistance Training with 15 minutes of cycling as a warm-up activity then HIRT through Quadriceps drill, Squats, Lunges, Leg press, Biceps curls and Deadlift with 120 seconds of rest interval between each set of exercise and between exercises will be performed by the participants with appropriate cool down through generalized stretching exercises. Participants will perform exercises twice weekly, 40-50 minutes/session for 12 weeks respectively.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Low-moderate Resistance Exercise Training
Description: Supervised Low-moderate Resistance Training with 15 minutes of cycling as a warm-up activity then Quadriceps drill, Squats, Lunges, Leg press, Biceps curls and Deadlift with 120 seconds of rest interval between each set of exercise and between exercises will be performed by the participants with appropriate cool down through generalized stretching exercises. Participants will perform exercises twice weekly, 40-50 minutes/session for 12 weeks respectively.
Study: NCT05268497

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Esketamine will be self-administered as nasal spray.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy (CBT)
Description: Clinician-directed CBT supplemented by the Mindset app will be administered.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Antidepressant
Description: Antidepressant will be administered orally.
Study: NCT05291806

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Reference Product
Description: This intervention is based on white rice.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Wholegrain product Dose A
Description: This wholegrain intervention contains whole cereal kernels.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Wholegrain product Dose B
Description: This wholegrain intervention contains whole cereal kernels.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Wholegrain product Dose A, cut kernels
Description: This wholegrain intervention contains cut cereal kernels.
Study: NCT05273177

Intervention type: OTHER
Intervention: Chronic ankle instability
Description: Persistent condition of ankle instability after a first ankle sprain episode.
Study: NCT05871190

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: İnjectable platelet rich fibrin
Description: I-PRF is a type of platelet-rich fibrin (PRF) product obtained from the patient's own blood. PRF is a kind of tissue regeneration product of blood, rich in platelets, growth factors and cellular components.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Gingivectomy anad gingivoplasty
Description: leveling and regulation of the gingiva

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Gingivectomy anad gingivoplasty
Description: leveling and regulation of the gingiva
Study: NCT04356638

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Midazolam
Description: Oral Midazolam and intranasal placebo

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexmedetomidine
Description: Intranasal Dexmedetomidine and oral placebo

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo orally and intranasally
Study: NCT06009263

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Conventional treatment
Description: Application of ultrasound and transcutaneous electrical nerve stimulation TENS for mechanical low back pain.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Open chain segmental control
Description: Application of open chain segmental control exercises As well as, application of ultrasound and transcutaneous electrical nerve stimulation TENS for mechanical low back pain.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Closed chain segmental control
Description: Application of closed chain segmental control exercises As well as, application of ultrasound and transcutaneous electrical nerve stimulation TENS for mechanical low back pain.