TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06795464

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Immersive Virtual Reality
Description: Participants in the experimental group will follow a treatment program that combines standard care with an immersive virtual reality (IVR) intervention. During the first 4 weeks, participants will undergo the IVR intervention, followed by the same standard treatment as the control group for the subsequent 8 weeks.~IVR Intervention Protocol:~Sessions and Equipment: Participants will attend up to 12 IVR sessions using a head-mounted device (HMD), the Meta Quest III, equipped with a hand-tracking system (Meta VR, Facebook, California) to enable interaction with the therapeutic software Dynamics PainRehab (Dynamics VR Rehab, Seville, Spain). The Meta Quest III HMD is chosen for its commercial availability, widespread use, minimal visual latency, and user-friendly interface. The software application, Hombro PainRehab, features multisensory inputs (vision and sound), high-quality graphics, head and hand tracking, and provides a highly immersive experience. The IVR intervention incorporate

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Exercise
Description: Participants assigned to the control group will receive standard treatment for rotator cuff-related shoulder pain. This will consist of standardized therapeutic exercise performed for 25 minutes, 3 times per week, over a 12-week period. The exercise regimen will be individualized based on intensity, utilizing the Rate of Perceived Exertion (RPE) scale, with the goal of achieving intensity levels of 6-8 on a scale of 0 to 10.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Exercise
Description: Participants assigned to the control group will receive standard treatment for rotator cuff-related shoulder pain. This will consist of standardized therapeutic exercise performed for 25 minutes, 3 times per week, over a 12-week period. The exercise regimen will be individualized based on intensity, utilizing the Rate of Perceived Exertion (RPE) scale, with the goal of achieving intensity levels of 6-8 on a scale of 0 to 10.
Study: NCT06793995

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY03017
Description: single dose，administered orally for each period

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY03017
Description: single dose，administered orally for each period

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY03017
Description: single dose，administered orally
Study: NCT06794255

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Vitamin C
Description: Participants swallow synthetic vitamin C tablets 500mg with water, twice a day.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants swallow tablets with the same texture, flavor, and appearance as the experimental group 500mg with water, twice a day.
Study: NCT06793514

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Probiotic
Description: The experimental group will receive the oral probiotics (Lactobacillus casei, Lactobacillus rhamnosus, Lactobacillus acidophilus, Lactobacillus bulgaricus, Bifidobacterium breve, Bifidobacterium infantis, Streptococcus thermophiles) alongside with fructooligosaccharide (FOS), which is prepared in the concentration of 109 cfu by Bisot Khimr and is in the form of an edible sachet that can be dissolved in cold water, which is consumed once a day for one month. Sachets should be stored at a temperature of 2 to 8 degrees Celsius (in the refrigerator), which increases the useful life of probiotic bacteria and makes them more effective.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Drug
Description: The placebo is also prepared in the form of probiotic supplement in the form of sachets with similar packaging by the bio-fermenting pharmaceutical company.
Study: NCT06795243

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PAIN NEUROSCIENCE EDUCATION AND THERAPEUTIC EXERCISE PROGRAM
Description: PAIN NEUROSCIENCE EDUCATION~1. Introduction to the knowledge of pain in the XXI century. Pain as an alarm system.~Types of pain. Differences between acute and chronic pain. 3. Chronic pain. Concepts of kinesiophobia, catastrophism and fear avoidance, self-determination and neuroplasticity.~4. Main pain management tools based on scientific evidence. 5. . Transtheoretical model of change. Adherence to treatment, importance as a determinant in health.~6. Messages for home. Strategies of active coping in the maintenance stage.~THERAPEUTIC EXERCISE PROGRAM 10-min warm-up. Joint mobility exercises with dual task or gamification. 30-min main part. Sequence of balance work between strength and body flexibility dosed according to the specific needs of each participant.~10-min cool down including breathing exercises and motor imagery. Home exercise program: walking (150 minutes in total, 3 days alternating with the face-to-face sessions).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: USUAL CARE
Description: The treatment provided is mainly pharmacological, adjusted to the symptomatic profile of theses patients.~Conventional medical care is based on hormonal, pharmacological and/or surgical treatment and is carried out on an individualized basis depending on the severity of the disease and the patient's needs, especially in matters of desire to become pregnant. Surgical treatment is carried out when pharmacological therapy (hormonal or anti-inflammatory) is ineffective or involves adverse events.
Study: NCT06788808

Intervention type: OTHER
Intervention: Comparison between groups
Description: Ultrasound images acquired during routine ultrasound scans performed in healthy fetuses and in fetuses found to have CNS malformations will be reviewed. Ultrasound images acquired from January 2000 to May 2021 will be analyzed until a sample size of approximately 80 patients is reached, who will be divided into 2 groups: group A (patients whose fetus has CNS malformations) and group B (healthy patients whose fetus has no anatomical CNS abnormalities).

Intervention type: OTHER
Intervention: Comparison between groups
Description: Ultrasound images acquired during routine ultrasound scans performed in healthy fetuses and in fetuses found to have CNS malformations will be reviewed. Ultrasound images acquired from January 2000 to May 2021 will be analyzed until a sample size of approximately 80 patients is reached, who will be divided into 2 groups: group A (patients whose fetus has CNS malformations) and group B (healthy patients whose fetus has no anatomical CNS abnormalities).
Study: NCT06796114

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: blood sample
Description: A total of 48 ml of blood will be collected at baseline (before STRIDE initiation):~* 6 EDTA 6 ml tubes for PBMC collection~* 2 EDTA 6 ml tube for plasma collection
Study: NCT06794502

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Herbal medicine
Description: Herbal medicine from butterfly pea flower decocta extract is used as an additional TB drug therapy regimen for active TB patients during the initiation phase of treatment for 2 months.

Intervention type: OTHER
Group type: OTHER
Intervention: Tuberculosis (TB) treatment
Description: The patients in anti-TB monotherapy group (Group 2) were given a regimen consisting of rifampicin, isoniazid, pyrazinamide, and ethambutol for 2 months. This group did not receive any additional therapy.
Study: NCT06795802

Intervention type: BEHAVIORAL
Intervention: Evaluative conditioning
Description: The evaluative conditioning procedure is a learning technique performed on a monitor. It consists of being exposed to the repeated association of an object (conditioned stimulus, in our case, Physical Activity or fruit and vegetables) to stimuli with a positive or negative valence (unconditioned stimulus, US). The total duration of the CE is approximately 15 minutes.

Intervention type: BEHAVIORAL
Intervention: Evaluative conditioning
Description: The evaluative conditioning procedure is a learning technique performed on a monitor. It consists of being exposed to the repeated association of an object (conditioned stimulus, in our case, Physical Activity or fruit and vegetables) to stimuli with a positive or negative valence (unconditioned stimulus, US). The total duration of the CE is approximately 15 minutes.
Study: NCT06108076

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketone Monoester (KE)
Description: Ketones are a nutritional supplement currently used by athletes for their performance enhancing effects - specifically their cardio-pulmonary benefits
Study: NCT06054165

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Clinical pathway
Description: Evidence-based and expert-opinion-based clinical pathway regarding the diagnostic and treatment strategy
Study: NCT06797414

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pilate Exercises
Description: PILATES EXERCISE METHODS:~1. The cranium, triceps, back, and shoulder blades against the mat, then breath while maintaining muscle contraction .~2. Arm circles (both directions) on the mat, then use strong ribcage breathing to connect into scapula.~3. Diamond press: lie prone on a mat, using the lower part of the trapezius and serratusanterior muscles to slide shoulder blades out and down. Move into slight back extension maintaining this position.~4. Diamond press: repeat above but add lateral arm movement to back extension .~5. Arm slides 90°: lies supine on mat with arms bent at 90° and thumbs on floor. Slide elbows on floor toward waistline while contracting serratus anterior muscle.Repeat on the floor with other fingers. Always maintain proper neck alignment .~6. Arm circles on a tiny barrel while lying on back with the head and neck supported by the barrel. Opened chest, then link the scapula to the barrel. Hold this position while performing arm circles.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Pilate Exercises
Description: PILATES EXERCISE METHODS:~1. The cranium, triceps, back, and shoulder blades against the mat, then breath while maintaining muscle contraction .~2. Arm circles (both directions) on the mat, then use strong ribcage breathing to connect into scapula.~3. Diamond press: lie prone on a mat, using the lower part of the trapezius and serratusanterior muscles to slide shoulder blades out and down. Move into slight back extension maintaining this position.~4. Diamond press: repeat above but add lateral arm movement to back extension .~5. Arm slides 90°: lies supine on mat with arms bent at 90° and thumbs on floor. Slide elbows on floor toward waistline while contracting serratus anterior muscle.Repeat on the floor with other fingers. Always maintain proper neck alignment .~6. Arm circles on a tiny barrel while lying on back with the head and neck supported by the barrel. Opened chest, then link the scapula to the barrel. Hold this position while performing arm circles.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Whole-body vibration
Description: Subjects were placed in a modified push-up position , put their hands in the middle of the platform, shoulder width apart, elbows slightly flexed, and their lower extremities were supported by kneeling on the floor . Vibration protocol included 5 sets of 60 s duration, at 5 mm amplitude and 30 Hz frequency, with a rest period of 60 s between sets . The subjects were reminded kneeling but upright and detached from the platform between sets.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Hot Pack
Description: for 10 to 15 minutes

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Hot Pack
Description: for 10 to 15 minutes
Study: NCT06792695

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Volrustomig
Description: Volrustomig will be administered as intravenous (IV) infusion.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: FOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)
Description: FOLFIRI will be administered as IV infusion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FOLFIRI (Fluorouracil (5-FU), leucovorin, irinotecan)
Description: FOLFIRI will be administered as IV infusion.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bevacizumab
Description: Bevacizumab will be administered as IV infusion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Bevacizumab will be administered as IV infusion.
Study: NCT06797310

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib
Description: This study evaluates the use of baricitinib 4 mg once daily for 16 weeks in patients with acute alopecia areata (AA) experiencing active hair shedding. Unlike prior studies focusing on chronic AA with extensive hair loss (SALT ≥ 50), this intervention targets the acute phase, aiming to halt shedding within 4-6 weeks-faster than conventional treatments like corticosteroids. Patients meeting the primary endpoint (iSARS-AA ≤ 20 at week 16) will taper to 2 mg daily for an additional 16 weeks. Scheduled follow-ups at weeks 0, 4, 8, 12, 16, 24, 32, 36, 44, and 52 ensure comprehensive monitoring, distinguishing this study from others with shorter follow-ups or less frequent assessments.
Study: NCT06792981

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Universal primary prevention program based on ICTs
Description: The intervention adopts a multicomponent approach, addressing three agents in the prevention and management of eating disorders: parents, teachers and students.~1. Intervention with parents:~   Parents will receive specific materials, including an informative guide on early identification of warning signs, promoting healthy lifestyle habits, and fostering effective communication with their children.~2. Intervention with teachers:~   A two-hour in-person session will train teachers on platform use and provide tools for eating disorder prevention through role-playing techniques. Online resources will complement the training, while researchers ensure adherence via weekly follow-ups and parent reminders.~3. e-Preta program: The intervention for minors is delivered through an online platform, structured into 9 sessions of 45 minutes each, over 3 months. Weekly, platform-guided activities are proposed for classroom use with minimal teacher interaction, along with voluntary at-home activities.
Study: NCT06794008

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BCMA-CD19 CAR-T therapy
Description: Patients received the BCMA-CD19-targeted CAR-T cells with a dosage of 3×10\^6/kg CAR-T cells per kilogram.
Study: NCT06794710

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: diuretics, ACEIs/ARBs, beta blockers, positive inotropic drugs, MRAs, SGLT2i, retinoids
Description: Patients in this group will receive pharmacological treatment for heart failure.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: diuretics, ACEIs/ARBs, beta blockers, positive inotropic drugs, MRAs, SGLT2i, retinoids
Description: Patients in this group will receive pharmacological treatment for heart failure.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Close follow-up
Description: High risk patients receive close follow-up

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: early rehabilitation guidance
Description: Early rehabilitation guidance such as cardiopulmonary exercise tests and cardiac rehabilitation therapy
Study: NCT06792643

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cangrelor
Description: Cangrelor will be started without bolus at a low dose of 0.125 mcg/kg/min and titrated (by 0.125 mcg/kg/min steps) based on the results of platelet function assay to guarantee effective platelet P2Y12 pathway inhibition.
Study: NCT06792838

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Confocal Laser Endomicroscopy
Description: 1. The Endo microscope probe will be prepped in channel #1 and normal saline (30 ml) will be flushed into the duodenal mucosa through channel # 2 which will serve as a control. Inject 1-3ml fluorescein 10% intravenously.~2. The duodenal mucosa is assessed at a minimum of four sites (20 seconds each~3. The first potential allergen will be sprayed via catheter onto the mucosa.~4. After 2 minutes, three different areas of of duodenum will be assessed with the gastroflex probe for fluorescein leakage and cell shedding. If fluorescein leakage and cell shedding are visualized that is considered a positive test,no further allergy testing can be conducted. If the first allergen test is negative, irrigate and repeat steps for the next potential allergen for a maximum of three allergens per patient.
Study: NCT06795308

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Bed Position and Head Elevation
Description: The first group will remain in the supine position for 6 hours after the Angiography procedure, and the treated leg will be kept straight and immobile. Patients will not move their legs during this period. A sandbag weighing approximately 4 kg will be placed over the catheter dressing for 6 hours to prevent bleeding and subcutaneous blood accumulation. For the first two hours, the patient will lie on his back and on a flat surface with his legs extended straight. During the remaining 4 hours, we will monitor the patient's bed head by raising it 15 degrees intermittently under the supervision of the doctor, and at the end of the 6th hour, the sandbag on the leg will be removed. Blood pressure, pulse rate, respiratory rate, body temperature, as well as pain level will be measured every two hours.
Study: NCT06794138

Intervention type: PROCEDURE
Intervention: dental implant placement
Description: The fit of the surgical guide was checked and a flapless procedure was performed under local anesthesia. However, in cases where the width of keratinized mucosa was insufficient a limited full-thickness flap was elevated. The surgical template was fixed on the remaining dentition and mucosa using template fixation pins. Fully guided implant bed preparation was performed. Osteotomies were carried out with external cooling at a drill rotation speed of 800 rpm. Implant placement was performed using a manual torque wrench Dental implants were placed non-submerged. In cases of flap elevation, wound margins were stabilized with single interrupted sutures. Sutures were removed at 7 days postop.
Study: NCT06796712

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Prebiotic fibre fortified bread roll
Description: Subjects will consume a prebiotic fibre-fortified bread roll (10g of added prebiotic fibre/day).

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Regular bread roll
Description: Subjects will consume a regular bread roll (0g of added prebiotic fibre blend/day).
Study: NCT06795412

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PYX-201
Description: Intravenous (IV) infusion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PYX-201
Description: Intravenous (IV) infusion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: pembrolizumab
Description: IV infusion.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: pembrolizumab
Description: IV infusion.
Study: NCT06793410

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Early start post-transplant vaccination with Gardasil 9®
Description: Subjects will receive Gardasil 9® as part of the early post-transplant vaccination, starting at 9 months after transplantation.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Late post-transplant vaccination with Gardasil 9®
Description: Subjects will receive Gardasil 9® as part of the late post-transplant vaccination, starting at 15 months after stem cell transplantation.
Study: NCT05849272

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: toludesvenlafaxine hydrochloride sustained-release tablets
Description: orally once a day
Study: NCT04168203

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban 2.5 MG
Description: apixaban 2.5 mg orally twice daily for a duration of 12 months

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo oral tablet
Description: placebo oral tables twice daily for a duration of 12 months
Study: NCT04563234

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: COFLEX neurocognitive training
Description: The COFLEX training group will then be provided with the cognitive training module and participants will be required to complete a targeted 30-minute daily training until the day of surgery, and then after the surgery, for a total of 6 weeks.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Crossword puzzles
Description: The control (crossword puzzles) group will be given a training module, where they can access crossword puzzles on the same platform, and can do puzzles whenever they desire over the 6-week time period.
Study: NCT06531213

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: experimental
Description: Experimental Group: Baseline rehabilitation, Visual Perception Interventions. Home base activities, Baseline Rehabilitation (Strengthing exercise, achieving missing milestones).~Visual Perception Interventions~• Puzzle:Give step-by-step • printable activities • Sudoku. SET, Search Word, Spot it, what is missing, Tic Tac Toe, I Spy

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: controlled
Description: Controlled: Baseline rehabilitation. Home-based activities, Baseline Rehabilitation (strengthening exercise, achieving missing milestones).3. Activities Play Dough ( Manipulation) Draw on sketch Cup stacking.
Study: NCT04524715

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Non-invasive red LLLT treatment to chest of patient.
Description: Expose patient to LLLT light while lying on their back, elevated at an angle of approximately 45 degrees from horizontal. Position light over the patient's chest at a 33-degree bias to their right and left sides for 20 minutes each side respectively.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Device Treatment
Description: Expose patient to sham device while lying on their back, elevated at an angle of approximately 45 degrees from horizontal. Position light over the patient's chest at a 33-degree bias to their right and left sides for 20 minutes each side respectively.
Study: NCT04480021

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MITHRA
Description: A mobile based application (app) in CBOs to screen, track and treat mild to moderate depression among low income women using Healthy Activity Program (HAP),a WHO-recommended evidence-based intervention.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: EUC
Description: Group education on depression by community health workers
Study: NCT04613713

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as usual
Description: The participants will follow the current treatment advice as recommended by the Vulva Clinic at OUH, a tertiary health care center specialized in treatment of vulvar disorders. Advice include guidance about the management of PVD as a condition, use of medication, physiotherapy, sexologist and psychological counseling, usage of internet resources (vulva.no) and others. Participants will be free to pursue treatment options of their choice. The type of treatment, number of treatments and medication usage will be monitored by bi-weekly electronic forms during the whole study period.
Study: NCT06172244

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Applying with whole body vibration device
Description: A total of 5 sets of vibration will be given at 30 Hz, 2 mm amplitude, 1 minute of application and 1 minute of rest.