TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06530459

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Menopausal hormone therapy
Description: Apply 17 beta-Estradiol topical gel (1.25-2.5 gms) daily Ingest Micronized Progesterone 200mg daily for 12 days each month

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise training
Description: Exercises would focus on upper and lower body strength generally. It is anticipated that the participants ideally should exercise at least 3 times per week based on the strength training prescription. They could potentially exercise everyday, alternating between upper and lower body strength training. In all, there are up to 1-2 in-person therapy sessions and home sessions at least 3 times per week.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Menopausal hormone therapy + exercise training
Description: 1. Apply 17 beta-Estradiol topical gel (1.25-2.5 gms) daily and Ingest Micronized Progesterone 200mg daily for 12 days each month~2. Exercises would focus on upper and lower body strength generally. It is anticipated that patients ideally should exercise at least 3 times per week based on the strength training prescription. They could potentially exercise everyday, alternating between upper and lower body strength training. In all, there are up to 1-2 in-person therapy sessions and home sessions at least 3 times per week.
Study: NCT04977232

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Escitalopram
Description: Selective serotonin reuptake inhibitors (SSRI) were most commonly used first line pharmacotherapy for depression.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Escitalopram
Description: Selective serotonin reuptake inhibitors (SSRI) were most commonly used first line pharmacotherapy for depression.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Game intervention
Description: Participants will be instructed to play the commercial video game for about 30-60 minutes at least three times per week.
Study: NCT06398184

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise + motor imagery and action observation
Description: A total of 8 sessions of 4 sets of knee extension exercises will be performed. During the breaks between each series, participants will perform a progressive protocol of action observation and motor imagery.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercise
Description: A total of 8 sessions of 4 sets of knee extension exercises will be performed.
Study: NCT05137158

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Intermittent theta burst stimulation
Description: Intermittent theta burst stimulation(iTBS) on the left DLPFC, the left DLPFC will be targeted utilizing the localite neuronavigation system. The stimulation intensity is set at 80% of resting motor threshold(RMT), and the other parameters are set to triplet 50Hz bursts, repeat at 5Hz, 2s seconds on and 8 seconds off, 600 pulses per session, total duration of 3 minutes and 20 seconds.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham stimulation
Description: The same procedure will be performed in sham group including the RMT assessment and the neuronavigation system for target localization, but the sham coil will vertical to the brain surface and deliver a very slight magnetic field, which have the same appearance and sound, and provide the same tactile sensations as the active coils.
Study: NCT05024162

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: MRT Accuracy
Description: Predicted Grade Group (GG) by the MRI-based Radiomics Tool (MRT) at each Magnetic Resonance Imaging of the Prostate (MRI-P)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: MRT Stability
Description: MRT's predicted GG at second MRI-P.
Study: NCT06526273

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PILI 'Āina
Description: Participants will receive the 3-month adapted Diabetes Prevention Program's Lifestyle Intervention. These lessons will be delivered by a trained community health worker. At 3 months, participants randomized to the PILI 'Āina intervention will receive a 6-month intervention centered around the use of a raised-bed home garden as the means of engaging household members to 1) increase their access to and intake of vegetables, 2) learn culturally relevant ways of preparing/cooking fresh vegetables through hands-on cooking lessons with local experts, and 3) build family cohesion through family bonding activities. Participants will be given all the equipment and materials (e.g., soil, seeds, instructions, setup of equipment) needed to grow their vegetables using their raised-bed home garden box throughout the entire study. They will receive seeds for the vegetables that can grow in a relatively short period (i.e., within 6 weeks).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Participants will receive the 3-month adapted Diabetes Prevention Program's Lifestyle Intervention. These lessons will be delivered by a trained community health worker based on previously tested materials and protocols. At 3 months, participants randomized to the control group will receive monthly untailored health education information and links to community resources from the community health worker via United States Postal Service or electronic messaging. Examples include information on food assistance programs, farmers' markets, cultural events, and physical activity events.
Study: NCT05614882

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Written Stroke Education
Description: The written education will be provided in the stroke folder currently in use by the Yale New Haven Health system. This written information is presented in a stroke folder and includes how to respond to the signs of stroke, dialing 9-1-1, following up with a health care provider after hospitalization due to a stroke and the importance of medication management as well as stroke risk factors, healthy eating habits, exercise habits, common changes following a stroke, stroke recurrence and stroke types. After being given two days to review the materials, patients will be asked to complete the stroke knowledge test (SKT). All participants will receive a health literacy assessment and based on their scores will be categorized into a high health literacy (HHL) or low health literacy group (LHL) prior to randomization.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Verbal Stroke Education
Description: Participants in the verbal education group will be provided with education over two days from therapists including occupational therapy, physical therapy, speech therapy as well as a physician or nurse. The disciplines will present general stroke information including causes, risk factors, prevention, nutrition and exercise recommendations, importance of managing chronic conditions and the significance of medication compliance. After the verbal education topics are presented, the participants will be tested with the stroke knowledge test (SKT) to measure learning. All the participants will receive a health literacy assessment and based on their scores will be categorized into a high health literacy (HHL) or low health literacy group (LHL) prior to randomization.
Study: NCT04662450

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ABM affective pain stimuli
Description: Patients undergo ABM training to shift attention away from affective pain stimuli

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ABM sensory pain stimuli
Description: Patients undergo ABM training to shift attention away from sensory pain stimuli

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Patients undergo ABM training to receive affective/neutral and sensory/neutral word pairs
Study: NCT05613231

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Aerobic plus muscle-strengthening physical activity intervention
Description: The intervention is a 12-week Spanish language, Internet-based intervention promoting both aerobic and muscle-strengthening physical activity for Latina women.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Original physical activity intervention
Description: The intervention is a 12-week Spanish language, Internet-based intervention promoting aerobic physical activity for Latina women.
Study: NCT06591468

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Prednisone 30-40 mg/day, at 7am in the morning, gradually reduced after 1 month (5mg every 7-14 days) to 5-10 mg for maintenance treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: UDCA (Ursodeoxycholic acid)
Description: 13-15 mg/kg/day

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: UDCA (Ursodeoxycholic acid)
Description: 13-15 mg/kg/day
Study: NCT06592079

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Immediate implant and connective tissue graft
Description: Tooth extraction and immediate implant placement as mentioned. Connective tissue grafts will be harvested from the hard palate and placed at the implant sites in a supra-periosteal partial dissection pouch prepared at the buccal aspect without using vertical incisions and without flap elevation. Sutures will be used to stabilize the graft in its desired place. Followed by customized healing abutment.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Immediate implant with connective tissue graft and bone graft
Description: Tooth extraction and immediate implant placement as mentioned. Connective tissue grafts will be harvested from the hard palate and placed at the implant sites in a supra-periosteal partial dissection pouch prepared at the buccal aspect without using vertical incisions and without flap elevation. Xenograft will placed to fill the jumping gap.Sutures will be used to stabilize the graft in its desired place. Followed by customized healing abutment.
Study: NCT06656494

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ICP-248
Description: Eligible patients will receive ICP-248 orally as per the protocol，once daily for every 28 days as one treatment cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azacitidine
Description: Eligible patients will receive azacitidine subcutaneously or intravenously as per the protocol，once daily on days 1-7 of each 28-day cycle.
Study: NCT06595290

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High intensity care
Description: This arm follows a structured algorithm for initiating and uptitrating all four pillars of HFrEF oral medications post-randomization (pre-discharge) and during at least 4 visits over 6 weeks post-discharge.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual care
Description: Patients will be managed by their cardiologist according to their usual practice. Follow-up appointments will be scheduled as per the cardiologist\&#39;s instructions. Participants will return to the recruiting study site for clinical outcome assessment by study investigators at 90 and 180 days post-discharge.
Study: NCT06661369

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sensory Perceptual Motor Training on Group
Description: 1. Sensory Input~   * Wheelbarrow walks, swimming, and drying off.~2. Proprioceptive~   * Climbing, pushing, pulling, and carrying heavy objects.~3. Vestibular~   * Swinging, trampolining, and playground games.~4. Tactile~   * Stereognosis training, textured paths, and messy play (mud, sand).~5. Motor Planning~   * Statue spinning, crawling through/under objects, and quick movements.~6. Balance and Posture~   * Various balance positions (e.g., hands and knees).~7. Ocular Control~   * Catching and tossing balls.~8. Bilateral Coordination~   * Activities using both sides of the body (e.g., stick ball).~9. Visual-Spatial~   * Walking, stair climbing, and puzzles.~10. Fine Motor Skills~    * Puzzles, bead stringing, and drawing.~11. Gross Motor~    * Standing, walking, running, and throwing games.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sensory Perceptual Motor Training on Individual
Description: 1. Sensory Input~   * Wheelbarrow walks, swimming, and drying off.~2. Proprioceptive~   * Climbing, pushing, pulling, and carrying heavy objects.~3. Vestibular~   * Swinging, trampolining, and playground games.~4. Tactile~   * Stereognosis training, textured paths, and messy play (mud, sand).~5. Motor Planning~   * Statue spinning, crawling through/under objects, and quick movements.~6. Balance and Posture~   * Various balance positions (e.g., hands and knees).~7. Ocular Control~   * Catching and tossing balls.~8. Bilateral Coordination~   * Activities using both sides of the body (e.g., stick ball).~9. Visual-Spatial~   * Walking, stair climbing, and puzzles.~10. Fine Motor Skills~    * Puzzles, bead stringing, and drawing.~11. Gross Motor~    * Standing, walking, running, and throwing games.
Study: NCT05698745

Intervention type: PROCEDURE
Intervention: bioespecimen samples
Description: Blood, serum, plasma, urine, stools, small/large bowel tissue.

Intervention type: PROCEDURE
Intervention: bioespecimen samples
Description: Blood, serum, plasma, urine, stools, small/large bowel tissue.

Intervention type: PROCEDURE
Intervention: bioespecimen samples
Description: Blood, serum, plasma, urine, stools, small/large bowel tissue.
Study: NCT04873934

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Inclisiran
Description: Inclisiran sodium 300 mg / 1.5 ml (equivalent to 284 mg of inclisiran)
Study: NCT06517017

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Isatuximab
Description: Subcutaneous isatuximab will be administered weekly on a 28-day cycle during the first two cycles, and every two weeks of a 28-day cycle thereafter. Dexamethasone will be administered on the days of isatuximab administration and can be discontinued after two cycles of therapy, or continued at discretion of investigator. Lenalidomide, will be added after two cycles of therapy have been completed.
Study: NCT05145504

Intervention type: DIAGNOSTIC_TEST
Intervention: Evaluation of IL-6 biomarkers in synovial fluid
Description: Evaluation of IL-6 biomarkers in synovial fluid in obese and normal weight patients with gonarthrosis

Intervention type: DIAGNOSTIC_TEST
Intervention: Evaluation of IL-6 biomarkers in synovial fluid
Description: Evaluation of IL-6 biomarkers in synovial fluid in obese and normal weight patients with gonarthrosis
Study: NCT06066333

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Ablative Radiotherapy
Description: All participants will first undergo ablative RT

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: After completion of ablative RT, all subjects may begin pembrolizumab treatment
Study: NCT03919162

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PQ912
Description: PQ912 150 mg tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PQ912
Description: PQ912 150 mg tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PQ912
Description: PQ912 150 mg tablets

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablets to mimic PQ912 150 mg tablets
Study: NCT05488522

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SBRT + atezolizumab and bevacizumab
Description: Stereotactic Body Radiotherapy (SBRT) is a radiation procedure that delivers precise doses of radiation in fractions. See following section for more information on the schedule, dose, volume, and simulation of SBRT.~Atezolizumab is an FDA-approved immune checkpoint inhibitor that is used in the treatment of advanced HCC. It is administered as a flat-dose 1200 mg intravenous infusion every three weeks.~Bevacizumab is an FDA-approved anti-VEGF monoclonal antibody that is used in the treatment of advanced HCC in combination with atezolizumab. It is administered as a weight-based dose of 15 mg/kg intravenous infusion every 3 weeks.
Study: NCT06692192

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: 25mg of psilocybin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: 25mg of psilocybin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: 1mg of psilocybin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: 1mg of psilocybin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Midazolam
Description: The goal of the midazolam dosing regimen is to induce amnesia of the psychedelic experience without inducing over-sedation during the dosing session.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Midazolam
Description: The goal of the midazolam dosing regimen is to induce amnesia of the psychedelic experience without inducing over-sedation during the dosing session.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Saline
Description: Saline will be administered as a placebo for midazolam

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Saline
Description: Saline will be administered as a placebo for midazolam
Study: NCT06418282

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dayspring
Description: NPCD
Study: NCT06700330

Intervention type: OTHER
Intervention: no intervention, observational study
Description: Only data from the patient file.
Study: NCT06705426

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Scapular mobilization with addition anterior, posterior ,caudal glenohumeral mobilization, infrared therapy, ultrasound therapy, pendulum exercises
Description: Scapular mobilization with addition anterior, posterior ,caudal glenohumeral mobilization, infrared therapy, ultrasound therapy, pendulum exercises

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Posterior capsular stretch with addition anterior, posterior ,caudal glenohumeral mobilization, infrared therapy, ultrasound therapy, pendulum exercises
Description: Posterior capsular stretch with addition anterior, posterior ,caudal glenohumeral mobilization, infrared therapy, ultrasound therapy, pendulum exercises
Study: NCT06727552

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Barzolvolimab
Description: Subcutaneous Administration

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Barzolvolimab
Description: Subcutaneous Administration

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Barzolvolimab
Description: Subcutaneous Administration

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Barzolvolimab
Description: Subcutaneous Administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching placebo
Description: Subcutaneous Administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Matching placebo
Description: Subcutaneous Administration
Study: NCT06722365

Intervention type: DEVICE
Intervention: Backscatter Quantitative Ultrasound
Description: The intervention consists of a regular abdominal ultrasound scan for fetal evaluation. The difference with a regular scan is that the scanner used to image the fetus provides access to raw/unprocessed ultrasound echo data that can be extracted from the scanner and processed offline (after acquisition) to extract compute backscatter quantitative ultrasound (bQUS) features. Thus, data acquisition does not represent a significant departure from conventional fetal imaging protocols. Other than the time needed to acquire the images, the participant will not perceive any difference from a regular fetal ultrasound scan.
Study: NCT06726941

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physiotherapy and Rehabilitation Practices
Description: It was planned to give the participants a routine stroke rehabilitation program consisting of 45 minutes of active, passive range of motion exercises and strengthening exercises, balance exercises, walking training and 20 minutes of bicycle ergometry, accompanied by a physiotherapist with at least 5 years of experience in stroke rehabilitation. It was planned to give passive bicycle ergometry to patients without voluntary muscle movement and muscle strength, and active bicycle ergometry to participants with voluntary muscle movement and muscle strength, with the bicycle rehabilitation. It was planned to apply the exercise program to the patients for 5 days a week and for a total of 30 sessions. It will be recommended that they continue the medical treatment they are using during the treatment program. Routine evaluations will be made by the physiatrist before the rehabilitation program starts and 2 tubes of venous blood will be taken from the patients by an experienced nurse
Study: NCT06745804

Intervention type: DRUG
Group type: OTHER
Intervention: 68Ga-R10602 injection
Description: 68Ga-R10602 is a gallium-labeled small molecule radioligand that is designed to localize tumor lesions in hormone receptor positive breast cancer

Intervention type: DRUG
Group type: OTHER
Intervention: 68Ga-R10602 injection
Description: 68Ga-R10602 is a gallium-labeled small molecule radioligand that is designed to localize tumor lesions in hormone receptor positive breast cancer
Study: NCT06743828

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fermented meat alternative
Description: Participants incorporate a novel fermented product into their habitual diet for three weeks. The product replaces the main protein source of the meal(s). Participants will receive dietary guidance on how to follow the intervention diet, as well as potential supplement recommendations provided by the authorized nutritionist.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Unfermented meat alternative
Description: Participants incorporate an unfermented product into their habitual diet for three weeks. The product replaces the main protein source of the meal(s). Participants will receive dietary guidance on how to follow the intervention diet, as well as potential supplement recommendations provided by the authorized nutritionist.
Study: NCT06748547

Intervention type: PROCEDURE
Intervention: scalp nerve block
Description: scalp nerve block is performed bilaterally by an anesthesiologist after induction of anesthesia and 5 minutes before head immobilization, according to the technique described by Pinosky et al. Prepare a syringe (20 mL) for scalp blocks. It is performed using 0.35% bupivacaine and 5 mcg epinephrine (1:2,000,000) using a 23-gauge needle inserted at a 45° angle to the skin and penetrating deeply into the outer edge of the scalp.

Intervention type: PROCEDURE
Intervention: scalp nerve block
Description: scalp nerve block is performed bilaterally by an anesthesiologist after induction of anesthesia and 5 minutes before head immobilization, according to the technique described by Pinosky et al. Prepare a syringe (20 mL) for scalp blocks. It is performed using 0.35% bupivacaine and 5 mcg epinephrine (1:2,000,000) using a 23-gauge needle inserted at a 45° angle to the skin and penetrating deeply into the outer edge of the scalp.
Study: NCT06749444

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: CBT-I
Description: Cognitive therapy tailored for insomnia symptoms.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: CBT
Description: Cognitive behavioral therapy for general psychopathology