Study: NCT05642143

Intervention type: DIAGNOSTIC_TEST
Intervention: Microindentation
Description: Measures Bone Material Strength Index (BMSi) of cortical bone.

Intervention type: DIAGNOSTIC_TEST
Intervention: Microindentation
Description: Measures Bone Material Strength Index (BMSi) of cortical bone.

Intervention type: DIAGNOSTIC_TEST
Intervention: Thermal perception thresholds
Description: Heat and cold perception thresholds

Intervention type: DIAGNOSTIC_TEST
Intervention: Thermal perception thresholds
Description: Heat and cold perception thresholds

Intervention type: DIAGNOSTIC_TEST
Intervention: Thermal perception thresholds
Description: Heat and cold perception thresholds

Intervention type: DIAGNOSTIC_TEST
Intervention: Nerve conduction studies
Description: Nerve conduction and amplitude of sural nerve

Intervention type: DIAGNOSTIC_TEST
Intervention: Nerve conduction studies
Description: Nerve conduction and amplitude of sural nerve

Intervention type: DIAGNOSTIC_TEST
Intervention: Nerve conduction studies
Description: Nerve conduction and amplitude of sural nerve

Intervention type: DIAGNOSTIC_TEST
Intervention: Composite Autonomic Symptom Score 31
Description: A validated self-assessment questionnaire quantifying the severity and distribution of autonomic symptoms across six domains (orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder and pupillomotor functions) by scoring 31 clinically selected questions

Intervention type: DIAGNOSTIC_TEST
Intervention: Composite Autonomic Symptom Score 31
Description: A validated self-assessment questionnaire quantifying the severity and distribution of autonomic symptoms across six domains (orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder and pupillomotor functions) by scoring 31 clinically selected questions

Intervention type: DIAGNOSTIC_TEST
Intervention: Composite Autonomic Symptom Score 31
Description: A validated self-assessment questionnaire quantifying the severity and distribution of autonomic symptoms across six domains (orthostatic intolerance, vasomotor, secretomotor, gastrointestinal, bladder and pupillomotor functions) by scoring 31 clinically selected questions

Intervention type: DIAGNOSTIC_TEST
Intervention: Skin biopsies with quantification of intra-epidermal nerve fibre density
Description: Skin biopsy

Intervention type: DIAGNOSTIC_TEST
Intervention: Skin biopsies with quantification of intra-epidermal nerve fibre density
Description: Skin biopsy

Intervention type: DIAGNOSTIC_TEST
Intervention: Perception Threshold Tracking
Description: Transcutaneous stimulation of large and small nerve fibres using weak electrical currents

Intervention type: DIAGNOSTIC_TEST
Intervention: Perception Threshold Tracking
Description: Transcutaneous stimulation of large and small nerve fibres using weak electrical currents

Intervention type: DIAGNOSTIC_TEST
Intervention: Perception Threshold Tracking
Description: Transcutaneous stimulation of large and small nerve fibres using weak electrical currents

Intervention type: DIAGNOSTIC_TEST
Intervention: Assessment of cardiovascular autonomic neuropathy
Description: Electrocardiographic recordings at rest and during cardiovascular autonomic reflex tests.

Intervention type: DIAGNOSTIC_TEST
Intervention: Assessment of cardiovascular autonomic neuropathy
Description: Electrocardiographic recordings at rest and during cardiovascular autonomic reflex tests.

Intervention type: DIAGNOSTIC_TEST
Intervention: Assessment of cardiovascular autonomic neuropathy
Description: Electrocardiographic recordings at rest and during cardiovascular autonomic reflex tests.

Intervention type: DIAGNOSTIC_TEST
Intervention: Handgrip strength
Description: Evaluation of muscle strength

Intervention type: DIAGNOSTIC_TEST
Intervention: Handgrip strength
Description: Evaluation of muscle strength

Intervention type: DIAGNOSTIC_TEST
Intervention: Handgrip strength
Description: Evaluation of muscle strength

Intervention type: DIAGNOSTIC_TEST
Intervention: Force plate platform
Description: Evaluation of balance while standing still

Intervention type: DIAGNOSTIC_TEST
Intervention: Force plate platform
Description: Evaluation of balance while standing still

Intervention type: DIAGNOSTIC_TEST
Intervention: Force plate platform
Description: Evaluation of balance while standing still

Intervention type: DIAGNOSTIC_TEST
Intervention: Biospecimen collection
Description: Biochemistry including bone turnover markers, glycemic status, inflammation markers i.e

Intervention type: DIAGNOSTIC_TEST
Intervention: Biospecimen collection
Description: Biochemistry including bone turnover markers, glycemic status, inflammation markers i.e

Intervention type: DIAGNOSTIC_TEST
Intervention: Biospecimen collection
Description: Biochemistry including bone turnover markers, glycemic status, inflammation markers i.e

Intervention type: DIAGNOSTIC_TEST
Intervention: Isometric leg extension strength
Description: Evaluation of muscle strength

Intervention type: DIAGNOSTIC_TEST
Intervention: Isometric leg extension strength
Description: Evaluation of muscle strength

Intervention type: DIAGNOSTIC_TEST
Intervention: Isometric leg extension strength
Description: Evaluation of muscle strength

Intervention type: DIAGNOSTIC_TEST
Intervention: Michigan Neuropathy Screening Instrument
Description: MNSI is used to assess status of peripheral neuropathy. It includes two separate assessments: a 15-item self-administered questionnaire and a lower extremity examination that includes inspection and assessment of vibratory sensation and ankle reflexes.

Intervention type: DIAGNOSTIC_TEST
Intervention: Michigan Neuropathy Screening Instrument
Description: MNSI is used to assess status of peripheral neuropathy. It includes two separate assessments: a 15-item self-administered questionnaire and a lower extremity examination that includes inspection and assessment of vibratory sensation and ankle reflexes.

Intervention type: DIAGNOSTIC_TEST
Intervention: Michigan Neuropathy Screening Instrument
Description: MNSI is used to assess status of peripheral neuropathy. It includes two separate assessments: a 15-item self-administered questionnaire and a lower extremity examination that includes inspection and assessment of vibratory sensation and ankle reflexes.