TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05056194

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Valiloxybate
Description: XW10172 MR Granules for Oral Suspension

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo Granules for Oral Suspension
Study: NCT05352737

Intervention type: DIAGNOSTIC_TEST
Intervention: methylmalonic acid testing

Intervention type: DIAGNOSTIC_TEST
Intervention: methylmalonic acid testing
Study: NCT04979338

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Bilateral spermatic cord block
Description: 10cc per spermatic cord of 0.5% bupivacaine \[administered by surgeon @ intraop\]

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Bilateral spermatic cord block
Description: 10cc per spermatic cord of 0.5% bupivacaine \[administered by surgeon @ intraop\]

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Pecs I & II Block
Description: 0.25% bupivacaine: 15-30mL per side for Pecs I-III

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Local anesthetic
Description: 0.25% or 0.5% bupivacaine into the appropriate surgical site

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Local anesthetic
Description: 0.25% or 0.5% bupivacaine into the appropriate surgical site

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Local anesthetic
Description: 0.25% or 0.5% bupivacaine into the appropriate surgical site
Study: NCT05779176

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Therapeutic hypothermia
Description: The study intervention is therapeutic hypothermia. After intubation, patients assigned to therapeutic hypothermia will receive central venous catheterization through right jugular vein or femoral vein depending on the cooling application and the unique needs, a flexible catheter will be inserted and iced saline was circulated through the multiple balloons of the catheter in a closed-loop design to induce therapeutic hypothermia. This system also has a hydrophilic coating with heparin and a triple-lumen central venous catheter to satisfy the need of fluid or drug infusion, blood draw and central venous pressure monitoring. After central venous catheterization, patients assigned to TH will receive intravascular temperature management to achieve the target temperature of 34-35 °C.
Study: NCT03095157

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: fractionated marine lipid concentrate derived from anchovy and sardine oil
Description: Patients will be randomized to receive perioperative treatment versus placebo

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: fractionated marine lipid concentrate derived from anchovy and sardine oil
Description: Patients will be randomized to receive perioperative treatment versus placebo
Study: NCT05131659

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Executive function group therapy
Description: This executive function group therapy curriculum for adolescents uses cognitive behavioral therapy techniques, and focuses on key functions needed for adult success, such as: self-advocacy, flexibility, time management, motivation, goal setting, developing plans, monitoring progress. Guided practice begins with concrete interventionist support and moves to interventionist cueing, self-cueing, and finally automatic use of the skills without support.
Study: NCT06166394

Intervention type: DRUG
Intervention: Spinal hypobaric Mepivacaine Local Anesthetic Injection
Description: • Administration of a hypobaric spinal mixture for Day-Surgery patients: 3.4ml of 1.5% mepivacaine created by 3ml 2% mepivacaine with 1ml sterile water, and then discarding 0.6ml

Intervention type: DRUG
Intervention: Spinal hypobaric Bupivacaine Local Anesthetic Injection
Description: Administration of a hypobaric spinal mixture for In-patients:~3ml of 0.33% bupivacaine created by 2ml 0.5% bupivacaine with 1ml sterile water
Study: NCT05352737

Intervention type: DIAGNOSTIC_TEST
Intervention: methylmalonic acid testing

Intervention type: DIAGNOSTIC_TEST
Intervention: methylmalonic acid testing

Intervention type: DIAGNOSTIC_TEST
Intervention: methylmalonic acid testing

Intervention type: DIAGNOSTIC_TEST
Intervention: methylmalonic acid testing
Study: NCT04999891

Intervention type: OTHER
Intervention: Neurocognitive tests
Description: Battery of neurocognitive tests and questionnaires including MoCA, PHQ-9, Falls History, FIFE, STOPBANG, Nutritional Survey, Global Physical Activity Questionnaire, Brief Pain Index, NuDESC, 3D-CAM.
Study: NCT05774262

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pacemaker implantation
Description: Elective pacemaker implantation (DDDR) for functional AVB according to the 2021 ESC Guidelines for Cardiac Pacing

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Cardioneuroablation (CNA)
Description: Experimental method; elective implantable loop recorder (ILR) and biatrial, binodal, atomically and electroanatomically guided CNA with extracardiac vagal nerve stimulation (ECVS) prior and after procedure monitoring (disappearance of ECVS-induced AVB with the goal of achieving post-procedure and maintaining a target heart rate \> 50 beats per minute). CNA procedure is performed with radio-frequency generators and irrigated catheters and with support of 3D-electroanatomic mapping system.~CNA group will receive external ECG recorders. The major reason for external ECG recorders is to provide documentation of clinical AVB, as well as monitoring of patients before and after CNA (or PM implantation, if accepted). In case of severe AVB symptoms always the emergency system will be called.
Study: NCT05255744

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Positive Airway Pressure (PAP) Therapy
Description: PAP therapy supplies pressurized air from the flow generator to the upper airway via air tubing and a mask to prevent the repetitive collapse of the upper airway during sleep.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Positive Airway Pressure (PAP) Therapy
Description: PAP therapy supplies pressurized air from the flow generator to the upper airway via air tubing and a mask to prevent the repetitive collapse of the upper airway during sleep.
Study: NCT06452121

Intervention type: OTHER
Intervention: triglyceride glucose index
Description: The TyG index was calculated using the following equation: Ln \[TG (mg/dL)×FPG (mg/dL) / 2\].~CAD was referred to as at least one major coronary artery with≥50% stenosis evaluated by CAG

Intervention type: OTHER
Intervention: triglyceride glucose index
Description: The TyG index was calculated using the following equation: Ln \[TG (mg/dL)×FPG (mg/dL) / 2\].~CAD was referred to as at least one major coronary artery with≥50% stenosis evaluated by CAG
Study: NCT06042764

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: SA55 Injection
Description: Novel coronavirus broad-spectrum neutralizing antibody SA55 injection (SA55 injection) is developed and produced by Beijing Kexing Zhongwei Biologics Technology Co., Ltd. The main component of SA55 injection is novel coronavirus broad-spectrum neutralizing antibody SA55. Each milliliter contains 150 mg of novel coronavirus broad-spectrum neutralizing antibody SA55. Excipients include histidine hydrochloride, arginine hydrochloride, histidine hydrochloride, sucrose, and polysorbate 80 (II)
Study: NCT05704608

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aerobic training
Description: Exercises on a treadmill at different speeds and inclination were performed.
Study: NCT04843644

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: honey
Description: Since the patient received radiation therapy, Taiwan Longan Honey has been used for a total of eight weeks.~Understand the changes of oral mucositis and various symptoms during this period

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: propolis
Description: Since the patient received radiation therapy, Taiwan green propolis has been used for a total of eight weeks.~Understand the changes of oral mucositis and various symptoms during this period
Study: NCT06042764

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SA55 Injection
Description: Novel coronavirus broad-spectrum neutralizing antibody SA55 injection (SA55 injection) is developed and produced by Beijing Kexing Zhongwei Biologics Technology Co., Ltd. The main component of SA55 injection is novel coronavirus broad-spectrum neutralizing antibody SA55. Each milliliter contains 150 mg of novel coronavirus broad-spectrum neutralizing antibody SA55. Excipients include histidine hydrochloride, arginine hydrochloride, histidine hydrochloride, sucrose, and polysorbate 80 (II)
Study: NCT03865160

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atropine eye drops, 0.01%
Description: One drop of the above mentioned drug will be installed into each eye daily at bedtime.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atropine eye drops, 0.02%
Description: One drop of the above mentioned drug will be installed into each eye daily at bedtime.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (NaCl 0.9%) eye drops
Description: One drop of the above mentioned drug will be installed into each eye daily at bedtime.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (NaCl 0.9%) eye drops
Description: One drop of the above mentioned drug will be installed into each eye daily at bedtime.
Study: NCT05901142

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise-based multi-phasic, multi-modal intervention
Description: Pre-op: 2\*60min supervised; 1\*30min unsupervised walking sessions per week Supervised session: Aerobic: 8\*60secs star jump, squat thrust, high knees with 90sec rest. Elastic resistance: 2\*10-12reps of chest press, seated row, leg press, 'lat' pulldown, and either abdominal flexion or lumbar extension-alternated, with 60-90sec rest. Targeted physiotherapy: general breathing exercises, active-assisted range of motion (RoM) exercises, and active-resisted RoM exercises~Postop: 1\*60min supervised exercise; unsupervised walking \[2\*30min weeks 1-2; 3\*30min week 3; 4\*30min weeks 4-6\] session per week Supervised session: Aerobic: As above using full body extension, squat jump, static sprint in week 1-4. Progressed to those performed preoperatively from week 5. Elastic resistance: As above from week 4, performed 3\*week. Targeted physiotherapy: As above, with active-assisted RoM progressing from 1\*10reps in week 1, to 2\*10reps in weeks 2-4, and 3\*10reps in weeks 4-6
Study: NCT04955236

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Partial scalp block
Description: Partial scalp blocks will be performed bilaterally after assuming the prone position.The Greater occipital will be blocked by injecting 3ml of local anaesthetic at a point half way between the mastoid process the external occipital protuberance along the superior nuchal line, medial to the occipital artery. The Lesser occipital nerve will be blocked by injecting 3ml of local anaesthetic infiltration along the superior nuchal line, 2.5 cm lateral to the greater occipital nerve block. The greater occipital nerve block also will cover the third occipital nerve due to the close location of the two nerves.~A placebo infusion (normal saline) will be administered at the same rate as fentanyl infusion in the active comparator arm(1 µg/kg/hr.).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fentanyl
Description: 1µg/kg/hr. of intravenous fentanyl infusion will be administered. A syringe filled with 20 ml of normal saline will be prepared and 3 ml of normal saline will be injected at the same points of the partial scalp block previously described
Study: NCT05231551

Intervention type: PROCEDURE
Intervention: Placental tissues
Description: Placental tissues are collected after aspiration of abortion products. They are treated immediately in order to isolate placental stem cells. Organoid culture is established and the obtained embryoids are cultured in monophasic or biphasic oxygen conditions. Extra organoids are cryopreserved in liquid nitrogen
Study: NCT06250946

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535;Placebo
Description: HRS-7535;Placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535;Placebo
Description: HRS-7535;Placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535;Placebo
Description: HRS-7535;Placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-7535;Placebo
Description: HRS-7535;Placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06498167

Intervention type: DRUG
Intervention: Upadacitinib
Description: Exposure to upadacitinib (Rinvoq™) in its different formulations approved by the Portuguese regulatory authority (15, 30, or 45mg extended-release tablets).
Study: NCT06501677

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: WBI
Description: The WBI will comprise of four sessions focusing on CRAFT principles including: (1) self-care, (2) positive communication including ways to increase responsiveness to the DP (PPR; i.e., actively listening, showing understanding, expressing interest in what their DP is thinking and feeling, and trying to see where the DPs is coming from), (3) understanding the DP's drinking reinforcers, and (4) supporting the DP if they want help and engaging in positive, healthy activities with the DP. ' partner.~Each module will take \~20-30 minutes and each session will: (1) instill optimism in CPs, (2) be solution-focused, (3) emphasize that the CP is not responsible for the DP's behaviors, and (4) use a nonjudgmental, non-confrontational, empathetic style. The WBI intervention is focused on reduced drinking in the DP and improved CP wellness.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: WBI
Description: The WBI will comprise of four sessions focusing on CRAFT principles including: (1) self-care, (2) positive communication including ways to increase responsiveness to the DP (PPR; i.e., actively listening, showing understanding, expressing interest in what their DP is thinking and feeling, and trying to see where the DPs is coming from), (3) understanding the DP's drinking reinforcers, and (4) supporting the DP if they want help and engaging in positive, healthy activities with the DP. ' partner.~Each module will take \~20-30 minutes and each session will: (1) instill optimism in CPs, (2) be solution-focused, (3) emphasize that the CP is not responsible for the DP's behaviors, and (4) use a nonjudgmental, non-confrontational, empathetic style. The WBI intervention is focused on reduced drinking in the DP and improved CP wellness.
Study: NCT04839484

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Study Product
Description: up to 2cc per injection of filler placed into nasolabial fold.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Active Control
Description: up to 2cc per injection of filler placed into nasolabial fold.
Study: NCT06151769

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: topical pomegranate seed oil
Description: Intervention groups: In addition to the routine care of the patients, Pomegranate seed oil will be applied to the sacrum and heels twice a day between 09.00-21.00 without pressing. 1.5 cc will be applied to the back of the sacrum and 1 cc to each heel, using circular movements without pressure for approximately 5 seconds. It will be waited for 2-3 minutes for the body to absorb the oil, then it will be touched and removed with a napkin without any rubbing movements. The application will be applied for 6 days. The patient follow-up form will be completed by the researcher every day at 12:00 noon. Again, on the 6th day of the application, evaluation surveys with the Braden risk assessment scale will be conducted by the researcher.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Sesame oil
Description: Sesame oil
Study: NCT05035277

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Acetylsalicylic acid
Description: Acetylsalicylic acid 75 mg once daily is the current standard-of-care in TAVI patients without other indications for anticoagulation therapy.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban
Description: Standard dose apixaban will be one of the options for the patients in the experimental arm.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rivaroxaban
Description: Standard dose rivaroxaban will be one of the options for the patients in the experimental arm.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Edoxaban
Description: Standard dose edoxaban will be one of the options for the patients in the experimental arm.
Study: NCT04065360

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Group Cognitive behavioural family intervention (CBFI)
Description: four-week, four-session CBT-based family intervention programme

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Usual group psychoeducation
Description: Treatment as usual in the institution studied
Study: NCT05523583

Intervention type: OTHER
Intervention: questionnaire
Description: A trained interviewer (Clinical Research Associate : CRA) will administer a questionnaire soon after the diagnosis on the phone (within 15 calendar days after diagnosis). The participants are followed up during the first year following the diagnosis through 3 follow-up assessments (at 3, 6, and 12 months after the baseline assessment) and hospital record reviews. At each follow-up, a brief questionnaire will be administered by an interviewer (CRA) via telephone.
Study: NCT05298345

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Family Champions Project Primary Services
Description: Primary Services: participants receive 12 hours of TYRO Leadership curricula, 6 hours of Core Communication curricula.~Support Services (optional): participants choose from a menu of classes (1-3 hours) at the walk-in mini clinic to meet a variety of self-identified needs.
Study: NCT05516979

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 100 mg AP1189
Description: AP1189 tablets for oral use

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching placebo for oral use
Study: NCT05185765

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Bread
Description: Samples will be provided one by one labeled with an unique code. The mastication and expectorated sample will be given in replicate.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Bread
Description: Samples will be provided one by one labeled with an unique code. The mastication and expectorated sample will be given in replicate.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Bread
Description: Samples will be provided one by one labeled with an unique code. The mastication and expectorated sample will be given in replicate.
Study: NCT05204901

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Insertion and withdrawal of a magnetic-tipped wire into the lumen of the nasogastric tube for tracking of its position
Description: In each participant, the investigator will place sensors on two sites of the sternum and track the location of the magnet as it is inserted and withdrawn from the nasogastric tube in the patients.
Study: NCT04754906

Intervention type: OTHER
Intervention: Sequence 1
Description: perform arm movements towards a target

Intervention type: OTHER
Intervention: Sequence 1
Description: perform arm movements towards a target

Intervention type: OTHER
Intervention: Sequence 1
Description: perform arm movements towards a target

Intervention type: OTHER
Intervention: Sequence 2
Description: judge the verticality of an object

Intervention type: OTHER
Intervention: Sequence 2
Description: judge the verticality of an object

Intervention type: OTHER
Intervention: Sequence 2
Description: judge the verticality of an object

Intervention type: OTHER
Intervention: Sequence 3
Description: In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.

Intervention type: OTHER
Intervention: Sequence 3
Description: In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.

Intervention type: OTHER
Intervention: Sequence 3
Description: In standing position, point as quickly as possible with the right arm at the diode that will light up in front of the participant.
Study: NCT04668885

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CPX-351
Description: Induction phase: CPX-351 15 mg/m\^2 on days 1 and 3 of each 28-day cycle for up to a total of 6 cycles in the absence of unacceptable toxicity~Maintenance phase: CPX-351 7.5 mg/m\^2 on days 1 and 3 for two cycles alternating with 15 mg/m\^2 for one cycle. Participants may receive up to 12 cycles of maintenance phase in the absence of unacceptable toxicity.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CPX-351
Description: Induction phase: CPX-351 15 mg/m\^2 on days 1 and 3 of each 28-day cycle for up to a total of 6 cycles in the absence of unacceptable toxicity~Maintenance phase: CPX-351 7.5 mg/m\^2 on days 1 and 3 for two cycles alternating with 15 mg/m\^2 for one cycle. Participants may receive up to 12 cycles of maintenance phase in the absence of unacceptable toxicity.
Study: NCT05170581

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sintilimab Combined with Platinum-containing Chemotherapy
Description: Admininster Sintilimab and platinum-containing chemotherapy in neoadjuvant treatment of resectable stage ⅡB～ⅢA Non-small Cell Lung Cancer
Study: NCT05551234

Intervention type: OTHER
Intervention: Regular exchanges
Description: The seniors and childrens will meet once a week, for 7 months, over a period of one and a half hours, outside school hours (4:30 p.m. to 6:00 p.m.) and school holidays.

Intervention type: OTHER
Intervention: Regular exchanges
Description: The seniors and childrens will meet once a week, for 7 months, over a period of one and a half hours, outside school hours (4:30 p.m. to 6:00 p.m.) and school holidays.
Study: NCT05250999

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Skin stretch sensory stimuli
Description: Skin stretch sensory stimuli will be exerted by a piece of kinesio tape that as applied above right and left lateral malleolus on posterior leg and on both side of spinous process of second thoracic vertebrae till 15cm below for 24 hours a day, 5 days/ week for 6 weeks along with conventional physiotherapy.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Transcutaneous Electrical nerve stimulation
Description: TENS will be applied to patient while in sitting position for 30 minutes, twice a week, and for 6 weeks (12 treatment sessions along with conventional physiotherapy). A maximum of 25 m amp electrical stimulation with a biphasic square-wave pattern and a pulse width of 0.5ms in a continuous duty cycle will be used. The intensity of the electrical stimulation will be regulated to the high tolerable level without initiating muscle contractions.