TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04565990

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selexipag
Description: Selexipag tablets will be administered orally at all dose strengths (200, 400, 600, 800, 1000, 1200, 1400 and 1600 microgram) twice daily.
Study: NCT05834725

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Promoting Resilience in Stress Management
Description: Resilience coaching program.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual Care
Description: Combination of physical therapy, occupational therapy, and psychological counseling as recommended by the treating provider.
Study: NCT04603092

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Digital Health Literacy Intervention
Description: Willing women participants will be provided equipment with instructions for the intervention, including a smartphone and a 4G Wifi gadget. The health literacy intervention, delivered to the experiment group, will last three months and will include a combination of the following four components:~Component 1: Health literacy video tutorial. Component 2: Virtual one-on-one weekly meetings. Component 3: Monthly group virtual meetings and Whatsapp group. Component 4: Provision and guidance of a self-management chart.
Study: NCT05402852

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: EuBone ® capsule
Description: Subjects are given EuBone® capsules, 4 capsules ×500mg/capsule per day for 360 days.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: Subjects are given placebo capsules, 4 capsules ×500mg/capsule per day for 360 days.
Study: NCT04894513

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kabat motor control re-education therapy
Description: Kabat motor control re-education therapy that includes specific movements with predefined patterns of facial muscles exercises, which is spiral and diagonal movements involve the facial muscles, which are brought to train in global patterns. The program of treatment for three times per week for six weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional selected program
Description: the conventional selected program in the form of electrical stimulation (Faradic current) of affected muscles, facial muscle exercise program in front of the mirror, and home advices.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional selected program
Description: the conventional selected program in the form of electrical stimulation (Faradic current) of affected muscles, facial muscle exercise program in front of the mirror, and home advices.
Study: NCT04999553

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Repetitive Transcranial Magnetic Stimulation
Description: rTMS will employ the MagPro X100/R30 stimulator equipped with the cool-B70 as we used a cool-B70 in our past non-inferiority trial. The dose will be a 120% rMT in accordance to our latest trial using iTBS. The target area to stimulate will be the right dorsolateral prefrontal cortex (DLPFC) for LFR and the left DLPFC for iTBS as established in prior clinical trials. The localization of both targets will follow the well-established procedures for either R-DLPFC or L-DLPFC using a heuristic method.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Repetitive Transcranial Magnetic Stimulation
Description: rTMS will employ the MagPro X100/R30 stimulator equipped with the cool-B70 as we used a cool-B70 in our past non-inferiority trial. The dose will be a 120% rMT in accordance to our latest trial using iTBS. The target area to stimulate will be the right dorsolateral prefrontal cortex (DLPFC) for LFR and the left DLPFC for iTBS as established in prior clinical trials. The localization of both targets will follow the well-established procedures for either R-DLPFC or L-DLPFC using a heuristic method.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Intermittent Theta Burst Stimulation (iTBS)
Description: Intermittent Theta Burst Stimulation (iTBS)

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Low Frequency Right (LFR)
Description: Low Frequency Right (LFR)
Study: NCT06300957

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Help Wanted Prevention Intervention
Description: The intervention includes an introductory welcome place, five training sessions that deliver core intervention content, and a resources page that provides links to external sources of support.~The Help Wanted Prevention Intervention is a free, online, self-help course to address the needs of people with a sexual attraction to children. Help Wanted aims to provide knowledge, skills, and resources to support help-seekers' commitments to living safe, healthy, and fulfilling lives.

Intervention type: OTHER
Group type: OTHER
Intervention: Waitlist Control
Description: Participants will be provided with information on how to access alternative resources and help lines to support mental health, suicide prevention, and child sexual abuse prevention. After one month, they will be granted access to Help Wanted.
Study: NCT05425888

Intervention type: OTHER
Intervention: Hemophilia group
Description: Evaluation of the study variables: dorsal flexion; dorsiflexion strength; tibialis anterior muscle activation; biomechanical analysis of gait and balance; and functionality.

Intervention type: OTHER
Intervention: Hemophilia group
Description: Evaluation of the study variables: dorsal flexion; dorsiflexion strength; tibialis anterior muscle activation; biomechanical analysis of gait and balance; and functionality.
Study: NCT06144671

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GT201
Description: Autologous tumor infiltrating lymphocyte injection
Study: NCT01215890

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: risedronate

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Study: NCT06246474

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: physical therapy program
Description: Arm Description: Adolescents in study group (B) will received the same designed physical therapy program for the control group in addition to Kinesio taping.
Study: NCT06025448

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: BIO-RSA
Description: Patients will have a reversed shoulder arthroplasty with lateralization of the joint centre using bony lateralization (BIO-RSA).

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: MIO-RSA
Description: Patients will have a reversed shoulder arthroplasty with lateralization of the joint centre using metallic lateralization (MIO-RSA).
Study: NCT04950075

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INBRX-109
Description: Tetravalent DR5 Agonist Antibody

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06042855

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Each study arm will contain a placebo comparator. Placebo will look similar to study drug and will be administered via the same route of administration and dose. However, placebo will be an inactive substance, containing no study drug.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: Metformin IR tablets contain the active metformin hydrochloride and inactive ingredients including povidone and magnesium stearate. Commercially available metformin 500 mg tablets will be provided.
Study: NCT05522270

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: revitalization by concentrated growth factor
Description: modified platelet concentrate

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: revitalization by concentrated growth factor
Description: modified platelet concentrate
Study: NCT02450981

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab (BCD-021)
Description: Bevacizumab is a monoclonal antibody against vascular endothelial growth factor A (VEGF-A)
Study: NCT05393960

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lumbosacral manual therapy mobilization, lumber mobility exercises and home based self strechings program.
Description: Manual therapy, mobility exercise therapy and a home-based self-stretching program. Manual mobilization postero-anterior glides at lumber facets joints, Transverse glides at spinous process \& Posterior-anterior glides at SI joint. Glides will be performed 3 times with 5 repetitions. Mobility exercise therapy.

Intervention type: OTHER
Group type: OTHER
Intervention: home based self strechings program only.
Description: Home based self-stretching program includes 3 repetitions of 15 seconds duration stretch (with 20 seconds rest between each repetition). Repeat stretching exercises twice a day for 3 alternate days for 1 week. Piriformis stretch: in supine crook lying, placing the lateral side of the foot over the contralateral knee and pulling towards the chest with the hands. Quadriceps stretch: stand on your left leg, one knee touching the other, hold a chair or the wall to keep you steady if needed, grab your right foot, using your right hand, and pull it towards your butt. Hamstring stretch: To stretch the right leg, sit on the ground with the left leg bent at the knee with the foot facing inward. This is called the butterfly position. Extend the right leg, keeping it slightly bent at the knee. Bend forward at the waist, making sure to keep the back straight.
Study: NCT06126848

Intervention type: DEVICE
Group type: OTHER
Intervention: Ambient sensor system
Description: Main study: A contactless non-intrusive ambient sensor system including infrared motion sensors combined with a contactless Emfit bed sensor will be installed in the home of single living study patients by using a commercially available System (Domo Health®, Lausanne) after informed consent has been obtained. Sensor data are prospectively followed over 3-6 months for predefined indicators of health deterioration. If indicators for health deterioration are present, patients will be called in to the hospital for cardiology consult by the study team including blood analysis for follow-up of BNP values and if necessary, therapy adaption.
Study: NCT04792749

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: Patients are given 750, 1500, and 2000 mgs of metformin per os daily (dose increases weekly, then maintain at 2000 mgs) in addition to 500 mgs of medroxyprogesterone acetate per os daily and levonorgestrel-releasing intrauterine device for the treatment of early stage endometrial cancer.
Study: NCT05189184

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Camrelizumab+Apatinib mesylate+Albumin-bound paclitaxel+cisplatin
Description: Camrelizumab in Combination With Apatinib mesylate Plus Albumin-bound paclitaxel and cisplatin as the First Line Treatment of Recurrent or Metastatic , UnresectableHead and Neck Squamous Cell Carcinoma (HNSCC)
Study: NCT05126056

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Plant stanol ester
Description: Product with active ingredient vs product without active ingredient

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT05944107

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Activated Clotting Time measurements combined with heparin concentration monitoring
Description: In the HC group, the initial heparin dose is calculated using the HepCon HMS Plus . Except for ACT, heparin concentration is measured to maintain target heparin levels during CPB. The protamine dose for reversal is computed based on actual measured heparin levels using the device. ACT is also performed in all instances.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Activated Clotting Time
Description: The target ACT for procedures other than Coronary Artery Bypass Grafting (CABG) is 400s when Minimally Invasive Extracorporeal Circulation is used. A bolus of 300 International Units(IU)/kg heparin are administered to reach this target and initiate cardiopulmonary bypass (CPB). Repeated ACT measurements guide further heparin dose to maintain adequate anticoagulation. Then, at the end of the CPB, 0.75 mg of protamine are administered for every 100IU of the initial heparin bolus.
Study: NCT05685979

Intervention type: PROCEDURE
Intervention: Robotic-assisted laparoscopic prostatectomy in deep Trendelenburg position.
Description: After general anesthesia induction, the patients were placed in the deep Trendelenburg position (at least 25°-45° upside down).
Study: NCT05432011

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PENG Block
Description: At the end of surgery, in Post Anesthesia Recovery Room (PACU), PENG block with 20 mL of 0.5 % Ropivacaine will be executed as described by Giron-Arango et al. using a low frequency curvilinear probe. A 22G 80 mm needle (Stimuplex Ultra 360, B.Braun) will be used.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: PENG Block
Description: At the end of surgery, in Post Anesthesia Recovery Room (PACU), PENG block with 20 mL of 0.5 % Ropivacaine will be executed as described by Giron-Arango et al. using a low frequency curvilinear probe. A 22G 80 mm needle (Stimuplex Ultra 360, B.Braun) will be used.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lateral Femoral Cutaneous Nerve Block
Description: At the end of surgery, in Post Anesthesia Recovery Room (PACU), ultrasound guided Lateral Femoral Cutaneous Nerve Block will be performed with 10 mL of 0.5 % Ropivacaine using a high frequency linear probe. A 22G 50 mm needle (Stimuplex Ultra 360, B.Braun) will be used.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Wound Infiltration
Description: At the end of operation, the surgeon will perform wound infiltration with 20 mL of 0.5 % Ropivacaine.
Study: NCT05533502

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Combined Plant-Based Protein and Marine-Based Multi-Mineral Supplement
Description: Ingestion of the Test Product at 07.00am - Fava-bean protein concentrate dosed at 0.33 g/kg body mass and Aquamin F dosed at 800mg in 500 ml water volume. Supplied by Marigot Limited, Strand Farm Currabinny, Co. Cork, Ireland

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Control
Description: Ingestion of the Control Product at 07.00am - 500ml water volume.
Study: NCT04558151

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: preoperative inspiratory muscle training
Description: Physiotherapists will measure the maximal inspiration pressure (MIP) with the POWER®breathe device of each single patient. Patients will then be instructed to perform inspiratory muscle training at the level of 60% of their individual MIP. Patients are instructed to perform the training containing of 30 breaths twice a day for 14-18 days before surgery. The devices are able to register the performance of each single training session and training results are monitored.
Study: NCT04816669

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT162b2
Description: Intramuscular injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT162b2
Description: Intramuscular injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT162b2
Description: Intramuscular injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT162b2
Description: Intramuscular injection

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: BNT162b2
Description: Intramuscular injection
Study: NCT06287099

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BRL-101
Description: Subjects will receive a single infusion of BRL-101.
Study: NCT06029855

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Kabat Therapy
Description: The participants of group A will receive Kabat Rehabilitation with routine physical therapy. The protocol will be given to the participants for three sessions/week for six weeks. Each session will be of 30 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mime Therapy
Description: The participants of group B will receive Mime Therapy in addition to routine physical therapy. The protocol will be given to the participants once a week for six weeks, while physical therapy will be given on alternate days. Each session will be of 30 minutes.
Study: NCT05457010

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SPRX002
Description: SPRX002 is a soluble protein with a TAG region to which ARC-T cells bind and a binding region targeting CD123

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: ARC-T Cells
Description: ARC-T Cells is a genetically modified autologous T-cell product. The T cell has a binding domain chimeric antigen receptor (CAR), which specifically binds to the TAG protein of the soluble protein antigen-receptor x-linker (sparX; specifically, SPRX002). When ARC-T cells bind to a TAG and the SPRX protein is bound to its target (in this case CD123), ARC-T cells are capable of activation, expansion, and killing (based on preclinical experiments).
Study: NCT05545540

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Musical Neurostimulation
Description: Daily exposure to musical composition found to have antiseizure properties

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Musical Neurostimuloation
Description: Daily exposure to musical composition found NOT to have antiseizure properties
Study: NCT04851262

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: The intervention is to be taught by fitness trainer at the participants' home at the start of each phase. The exercise progression model for older adults recommended by the American College of Sports Medicine, which emphasise gradual increments in training load and systematically alter one or more programme components, will be adopted.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Exercise
Description: The intervention is to be taught by fitness trainer at the participants' home at the start of each phase. The exercise progression model for older adults recommended by the American College of Sports Medicine, which emphasise gradual increments in training load and systematically alter one or more programme components, will be adopted.
Study: NCT05676021

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: motivational interview
Description: motivational interview-based health education
Study: NCT05592587

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Evaluation of the effectiveness of eye massage device producing both vibrations and nature sounds distraction in the management of anxious pediatric patients during inferior alveolar nerve.
Description: The child will be provided inferior alveolar nerve during eye massage device producing both vibrations and nature sounds. Children will be assessed by using a combination of measures: Wong-Baker faces and the Children's Fear Scale (self-report), heart pulse rate and blood pressure (physiological), and behavior (using Anxiety levels using Face - Legs - Activity - Cry - Consolability FLACC scale external evaluator). Acceptance will be measured using a two-point Likert scale

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Evaluation of the effectiveness of eye massage device producing vibratory stimulations distraction in the management of anxious pediatric patients during inferior alveolar nerve.
Description: The child will be provided inferior alveolar nerve during eye massage device producing vibratory stimulations. Children will be assessed by using a combination of measures: Wong-Baker faces and the Children's Fear Scale (self-report), heart pulse rate and blood pressure (physiological), and behavior (using Anxiety levels using Face - Legs - Activity - Cry - Consolability FLACC scale external evaluator). Acceptance will be measured using a two-point Likert scale

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Evaluation of the effectiveness of basic behavior guidance techniques without using any type of distraction aids in the management of anxious pediatric patients during inferior alveolar nerve.
Description: The child will be provided inferior alveolar nerve during eye massage device producing vibratory stimulations. Children will be assessed by using a combination of measures: Wong-Baker faces and the Children's Fear Scale (self-report), heart pulse rate and blood pressure (physiological), and behavior (using Anxiety levels using Face - Legs - Activity - Cry - Consolability FLACC scale external evaluator). Acceptance will be measured using a two-point Likert scale
Study: NCT04785469

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low-load eccentric training
Description: * Aerobic exercise training on a downhill walking treadmill with the following settings: 10% negative incline and constant speed corresponding to 75% of the average speed recorded during the initial 6-Minute walk test.~* Resistance training: 5 minutes of warm-up on the manual ergometer, then 3 sets for 10 repetitions of the leg extension (performed unilaterally in eccentric phase) with a load of 75% of 1 repetition maximum (concentric) for the first two weeks. The following two weeks, 3 sets for 10 repetitions will be performed on the leg press (performed unilaterally in the eccentric phase) with 75% load of 1 repetition maximum (concentric). In addition, patients will perform 3 upper extremity strengthening exercises (free weights or elastic bands), including 2 sets of 10 repetitions for each exercise.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual care
Description: * Aerobic exercise training using the cycle ergometer at an intensity calculated as follows: 2 minutes with load equal to 20% of maximum load, then 25 minutes with initial load at 50% of maximum load calculated as 103.217 + (30.500xGender) + (-1.613xAge) + \[0.002x6-Minute walk work (6MWW)\]. \[Sex: female = 0; male:1\] \[6MWW = 6-Minute walk distance x weight in kg\].~* Resistance training: 5 minutes of warm-up on the manual ergometer, then 5 exercises for upper and lower limbs performed with free weights or elastic bands. For the first 2 weeks will be performed 2 sets X 20 repetitions with 1 minute break between sets and a load that allows to perform no more than 20 repetitions. For the following 2 weeks, 3 sets of 10 repetitions x 10 repetitions with 2 min break between sets and a load that allows for no more than 10 repetitions.
Study: NCT04884178

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Trifocal Preloaded IOL Delivery System
Description: UV and blue-light filtering foldable trifocal IOL with a +2.2 diopter (D) addition power of intermediate visual acuity and a +3.3 D addition power of near visual acuity. This device is approved in Taiwan.