TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05858606

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Evaluation of the prevalence of truly (authentified) idiopathic short stature after multidisciplinary clinico-radiological evaluation
Description: 1. pre-inclusion consultation~2. inclusion consultation~   * personal history~  * height, weight, cranial perimeters, and spans of both parents~  * clinical examination of the child~  * photographs of the child~  * additional X-rays

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: analysis in a multidisciplinary consultation meeting via a secure platform (ShareConfrère) for evaluation by multidisciplinary team
Description: multidisciplinary team (geneticist, orthopedist, radiologist, pediatric endocrinologist) which will assign each patient an orientation:~* either to the non idiopathic short stature group (syndromic diagnostic orientation or to a constitutional bone pathology)~* or to the authentified idiopathic short stature group

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: Whole genome analysis for authentified idiopathic short stature
Description: For the first 30 patients included in the authentified idiopathic short stature group, a whole genome analysis in trio (child + parents) will be performed as part of the research.~For these 30 patients in the authentified idiopathic short stature group, the teleconsultation carried out for the submission of the multidisciplinary consultation meeting conclusions will make it possible to establish the family tree, to explain the interest and limits of the analysis, and to submit the consents dedicated to the genetic analysis.
Study: NCT06264063

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: EEG power in alpha band
Description: partecipants were submitted to registration of electrical activity with EEG to study the EEG power in alpha band

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: EEG power in alpha band
Description: partecipants were submitted to registration of electrical activity with EEG to study the EEG power in alpha band
Study: NCT05919719

Intervention type: PROCEDURE
Intervention: Non interventional study (study of diagnostic accuracy with an extra echocardiographic assessment).
Description: Fluid expansion will be delayed while our index test is performed. After fluid expansion, patient will undergo an echocardiographic assessment of response to fluid expansion (gold-standard).~Our index test is the ΔSVi-AC: indexed percentage of stroke volume variation between baseline and during a standardized abdominal compression. Stroke volume will be assessed by transthoracic echocardiography.~Patient will undergo 3 echocardiographic assessment: At baseline, During abdominal compression, After the 10 to 20ml/kg crystalloid fluid expansion Abdominal compression : a sphygmomanometer will be inflated to a pressure of less than 10 mmHg and will be applied to the center of the patient's abdomen. Then, a gentle compression on the sphygmomanometer will be performed, calibrated at 22 - 26 mmHg according to the sphygmomanometer. The echocardiographic assessments will take place between 10 and 60 seconds after the start of the compression, which will therefore last less than a minute.
Study: NCT05178342

Intervention type: DRUG
Group type: OTHER
Intervention: CA-4948
Description: Patients will be treated orally with CA-4948 at 300 mg BID (2x200mg) over 4 cycles. One cycle consists of 28 days, 21 of which are treatment days, followed by 7 days off.~Patients with erythroid response (HI-E) after 4 cycles who tolerate CA-4948 may continue to receive CA-4948 until loss of HI-E response.
Study: NCT05939492

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-Based Intervention
Description: Participants in the mindfulness-based intervention (MBI) group will be asked to use the Headspace app to sequentially complete the Basics, Basics 2, and Basics 3 courses. Each of these courses lasts 10 days, and participants have the ability to choose how long daily sessions last. Participants can choose between 3, 5, or 10-minute sessions for the Basics course; 10 or 15-minute sessions for the Basics 2 course; and 10, 15, or 20-minute sessions for the Basics 3 course. These daily sessions are audio recordings that prompt users to engage in a variety of mindfulness techniques, including focusing on their body and breathing, as well as acknowledging thoughts and emotions in a non-judgmental manner.
Study: NCT04301765

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: testosterone 1.62% gel
Description: The gel will be applied daily by the participants (all participants will be trained in the application process and will be given printed instructions). The intervention will be for 6 months

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo gel
Description: The gel will be applied daily by the participants (all participants will be trained in the application process and will be given printed instructions). The intervention will be for 6 months
Study: NCT05478070

Intervention type: DEVICE
Group type: OTHER
Intervention: Dexcom G6
Description: Continuous glucose monitor
Study: NCT05709210

Intervention type: OTHER
Group type: OTHER
Intervention: Recording of smartphone usage data
Description: Recording of smartphone usage data
Study: NCT04720196

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Active repetitive transcranial magnetic stimulation
Description: High frequency rTMS over the primary motor area to induce the long term potentiation of primary motor areas for the muscles of upper extremity.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham repetitive transcranial magnetic stimulation
Description: Sham stimulation to mimic the high frequency rTMS over the primary motor area.
Study: NCT05016388

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Collaborative Multidimensional Model (CMD)
Description: The teams enrolled in the CMD intervention will have a 22-hour training that integrates current knowledge of depression with skills for the management of functional variables, interpersonal, social, emotional regulation, and history of biographical adversity from childhood considering the trauma informed care paradigm. After the training, the PHC teams will implement the depression treatment according to a collaborative model.

Intervention type: OTHER
Group type: OTHER
Intervention: Standard Model (SM)
Description: The teams enrolled in the SM intervention will have a 22-hour training that integrates the current national clinical guide for Depression in Chile. This guide offers a staggered treatment according to the severity of the depression. After the training, the PHC teams will implement the depression treatment according to the SM.
Study: NCT05813769

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Dairy protein
Description: During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.
Study: NCT05289609

Intervention type: PROCEDURE
Intervention: Liver Transplantation
Description: Individuals with end-stage liver disease will be subjected to liver transplantation from deceased or living donors

Intervention type: PROCEDURE
Intervention: Liver Transplantation
Description: Individuals with end-stage liver disease will be subjected to liver transplantation from deceased or living donors
Study: NCT05813769

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Dairy protein
Description: During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Dairy protein
Description: During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Plant protein
Description: During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Plant protein
Description: During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Plant protein
Description: During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Plant protein
Description: During each visit, research subjects will receive the product dissolved in water, representing a 20g protein load.
Study: NCT05336877

Intervention type: DEVICE
Intervention: Aveir VR Leadless Pacemaker System
Description: This study will utilize real-world data from patients implanted with the Aveir VR Leadless Pacemaker System. No device intervention is required in this study.

Intervention type: DEVICE
Intervention: Single-Chamber Transvenous Pacemaker
Description: This study will utilize real-world data from patients implanted with a single-chamber transvenous pacemaker as a comparator to the Aveir VR LP system study arm. No device intervention is required in this study.
Study: NCT06437223

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tonabersat
Description: Tonabersat 40mg. Two tablets per day

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo 40mg, Two tablets per day
Study: NCT06538415

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pulse Diet
Description: Participants will consume cooked pulse (112 calories -lentils, red kidney beans, black beans, and pinto beans) during 14 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control Rice Diet
Description: Participants will consume cooked rice (112 calories) during 14 weeks.
Study: NCT05352451

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Interventional Survey
Description: Complete the surveys before and after attending coaching sessions. The two interviews each lasting for about one hour and will be done in-person or through video-conferencing meeting (depending on which is more convenient for you) with a study team member. The first interview, will ask about some basic information. In the second and last interview, will ask about experience of the coaching sessions and about how you feel about your decisions regarding your treatment and care. At each of the two time points, you and your caregiver will be interviewed separately. The video-conferencing, will be conducted through Zoom, which is a secure, widely used software which allows people to communicate remotely with computers, tablets, or smart phones. The software is available free of charge to you if you have a computer or other suitable device and internet.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Interventional Survey
Description: Complete the surveys before and after attending coaching sessions. The two interviews each lasting for about one hour and will be done in-person or through video-conferencing meeting (depending on which is more convenient for you) with a study team member. The first interview, will ask about some basic information. In the second and last interview, will ask about experience of the coaching sessions and about how you feel about your decisions regarding your treatment and care. At each of the two time points, you and your caregiver will be interviewed separately. The video-conferencing, will be conducted through Zoom, which is a secure, widely used software which allows people to communicate remotely with computers, tablets, or smart phones. The software is available free of charge to you if you have a computer or other suitable device and internet.
Study: NCT06612970

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HB0056
Description: HB0056 Injection

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HB0056
Description: HB0056 Injection

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HB0056
Description: HB0056 Injection

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HB0056
Description: HB0056 Injection

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HB0056
Description: HB0056 Injection

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HB0056
Description: HB0056 Injection

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: HB0056
Description: HB0056 Injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06705816

Intervention type: OTHER
Intervention: None interventional
Description: This is an observational study
Study: NCT05709886

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: EUS-LA by LaserPro Diode Laser System
Description: This trial is a prospective, single-arm, multi-center clinical trial. Four hospitals with national medical trial institution qualifications are selected as clinical trial centers. Qualified participants will receive endoscopic ultrasound (EUS)-guided laser ablation (LA) by LaserPro Diode Laser System according to the routine procedures. The results will be recorded according to the requirements of the primary and secondary efficacy indicators. After then, statistical comparisons of effectiveness and safety of the procedure will be made according to groups.
Study: NCT06722781

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Unified Protocol
Description: The UP is a transdiagnostic treatment that was designed to be relevant to a wide range of emotional disorders, given the common co-occurrence of depression, anxiety, somatoform and dissociative symptoms. It is based on Cognitive and Behavioural Therapy (CBT) and emotion regulation theories, and the aim is to support patients to apply a series of emotion regulation skills that target the core common vulnerabilities that underlie a range of mental health problems: neuroticism, low perceived control, and overestimation of threat. Contents are organised across 8 modules delivered online across 12 weekly 1.5 hour sessions and will include a combination of internet-based resources (self-monitoring questionnaires, psychoeducational videos, skills practices linked to each module) and group therapy sessions delivered by a qualified cognitive behavioural therapist.
Study: NCT06724185

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: LP28 capsule
Description: LP28 capsule : 5.0×10\^9 CFU/capsule

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Capsule
Description: Maltodextrin
Study: NCT06748833

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SMILE Intervention App
Description: The SMILE app, an iOS and Android compatible smartphone app, is based on effective CBT-based treatment features to help patients manage anxiety symptomology. Access requires a unique login. The SMILE app utilizes three relaxation features: calm breathing, mindfulness meditation, and deep muscle relaxation; one cognitive feature, thought journaling and the challenging of thoughts; one self-monitoring technique; a positive imagery game; and a feature aimed to reduce avoidance behaviour through exposure. The app will be self-guided, with no additional human involvement needed. Participants will be instructed to actively engage with at least one of the app's major functions for a minimum of 3 minutes per day.
Study: NCT06758258

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Negative Pressure Wound Therapy
Description: Preparations for NPWT:~1. Impressions \& Model:~   Lower jaw impressions were taken with alginate and modified trays for optimal tissue recording.~   Dental plaster models were created.~2. Splint Fabrication \& Connection:~2mm hard splints were thermoformed and modified for vacuum. Intraoral splint fit was assessed, and soft acrylic ensured an airtight seal. The irrigation hose was connected to the splint via cyanoacrylate adhesive. 3. NPWT Application: The physiodispenser pump was operated in reverse at reduced power (10-20%). Three 1-hour NPWT sessions were performed.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Therapy
Description: The same preparations will be conducted for the sham application arm, except that the peristaltic pump of the physiodispenser will remain inactive during application.
Study: NCT06757465

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Counseling education based on Watson's Theory of Human Caring
Description: In this study, a total of 75 interviews were conducted with 25 participants in the intervention group in three sessions. During the interviews, counseling training based on Watson IBK developed by the researchers was applied. Each session lasted between 30-45 minutes per participant. The first session was conducted face-to-face, and the second and third sessions were conducted using online platforms (Zoom, Microsoft Teams, WhatsApp video call) within the scope of telehealth applications. Sessions were structured according to the individual needs of the participants and the durations were arranged flexibly when necessary. Telehealth applications provided easy access to the participants during the counseling process and supported the continuity of individual counseling services.
Study: NCT06757946

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Mulligan Medial/Lateral glide with compression/ decompression technique
Description: Warm up (10 minutes with hot pack) and cool down exercises for a period of 5 to 10 minutes was given before starting and after the completion of exercises in supervised exercise program in all the groups. The following ergonomical advice were given to all the subjects, Avoid extreme knee bent positions, avoid squatting, crossed-leg sitting, frequent stair climbing or lifting heavy objects, avoid fatiguing postures except for infrequent short durations tasks, change posture frequently and use support where possible and avoid giving excess strain to the knees.~Mulligan mobilisation consisted of Medial glide mobilisation with movement, Lateral glide mobilisation with movement, with active knee flexion (61) depending on the subjects condition. The gliding force was sustained while the patient performed 3 sets of 10 repetitions.~Total 12 treatment sessions was given to each subject with the frequency of 3 sessions per week for 4 consecutive weeks.

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Mulligan Medial/Lateral glide
Description: Warm up (10 minutes with hot pack) and cool down exercises for a period of 5 to 10 minutes was given before starting and after the completion of exercises in supervised exercise program in all the groups. The following ergonomical advice were given to all the subjects, Avoid extreme knee bent positions, avoid squatting, crossed-leg sitting, frequent stair climbing or lifting heavy objects, avoid fatiguing postures except for infrequent short durations tasks, change posture frequently and use support where possible and avoid giving excess strain to the knees.~Total 12 treatment sessions was given to each subject with the frequency of 3 sessions per week for 4 consecutive weeks. After completing the therapeutic session, post- intervention data of the outcome parameters were taken.
Study: NCT06757881

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Gene modified anti-IL1RAP Chimeric Antigen Receptor T Cells :1.0×10^8(First dose group)
Description: Different dose groups

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Gene modified anti-IL1RAP Chimeric Antigen Receptor T Cells :2.5×10^8(Second dose group)
Description: Different dose groups

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Gene modified anti-IL1RAP Chimeric Antigen Receptor T Cells :5.0×10^8（Third dose group）
Description: Different dose groups
Study: NCT06758414

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy for Chronic Pain (CBT-CP)
Description: Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) will be conducted in accordance with the Cognitive Behavioral Therapy for Chronic Pain: Therapist Manual and the VA Evidence-Based Practice (EBP) roll-out training. CBT-CP consists of a 12-session protocol, including an initial assessment session (BL assessment; Session 1), 10 content-specific sessions (pain education, goal-setting, cognitive and behavioral skill building; Sessions 2-11), and a booster session scheduled approximately one month after the final CBT-CP session (Session 12). Participants randomized to the CBT-CP condition (n = 30) will complete one 60-minute individual session per week. Each CBT-CP session will be led by a trained study interventionist using a manualized curriculum, following a basic structure including review of previous session material, introduction of new information or skills, and discussion of how to implement learned material into a home action plan.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Health & Wellness (H&W)
Description: Health \& Wellness (H\&W) was developed by VISN 5 MIRECC investigators and consists of psychoeducation on topics related to physical and emotional wellbeing. Its structure is similar to CBT-CP (10 weekly individual 60-minute sessions, no booster session). Each Health \& Wellness session will be led by a trained interventionist using a manualized curriculum that includes review of previous session material, introduction of new information, and discussion of a range of health-related topics (physical activity/exercise, nutrition/healthy eating, managing medications and side effects, and addictive behaviors (e.g., substance use, gambling, eating) that do not include pain. Typical sessions include discussion of the impact of the topic on overall health and well-being, identifying benefits and challenges to improving or maintaining health in that area, and strategies to address challenges in that area.
Study: NCT06284785

Intervention type: PROCEDURE
Intervention: Bariatric surgery
Description: Patients included in our obese patient group are all scheduled to undergo bariatric surgery