TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06774547

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Heavy-slow resistance training
Description: Heavy-slow resistance training consists of a progressive protocol of dynamic exercises where the relative load increases over time from a weight that can only be lifted 15 times (i.e., 15 repetition maximum) during the first week to a relative load of 6 repetition maximum from Week 9 to 12. The exercises are performed unsupervised three days per week separated by a minimum of 48 hours. There are two exercises that are performed for four sets separated by a 2-minute rest. Participants with Achilles tendinopathy or plantar fasciopathy perform seated and standing weighted heel raises and participants with patellar tendinopathy perform a free-standing squat and a seated leg press. Tolerable pain during the exercises is allowed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Heavy-slow resistance training
Description: Heavy-slow resistance training consists of a progressive protocol of dynamic exercises where the relative load increases over time from a weight that can only be lifted 15 times (i.e., 15 repetition maximum) during the first week to a relative load of 6 repetition maximum from Week 9 to 12. The exercises are performed unsupervised three days per week separated by a minimum of 48 hours. There are two exercises that are performed for four sets separated by a 2-minute rest. Participants with Achilles tendinopathy or plantar fasciopathy perform seated and standing weighted heel raises and participants with patellar tendinopathy perform a free-standing squat and a seated leg press. Tolerable pain during the exercises is allowed.
Study: NCT06126991

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cetirizine
Description: Oral administration of cetirizine at 10mg once daily will be used.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Midazolam and Fentanyl
Description: Midazolam 50mg + fentanyl 300ug micro pump push will be used with a starting dose of 5ml/hour, adjusted according to the patient's level of sedation. The patient's RASS score will be maintained between -1-0 and the drug will be suspended with a blood pressure below 90/60mmHg.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Midazolam and Fentanyl
Description: Midazolam 50mg + fentanyl 300ug micro pump push will be used with a starting dose of 5ml/hour, adjusted according to the patient's level of sedation. The patient's RASS score will be maintained between -1-0 and the drug will be suspended with a blood pressure below 90/60mmHg.
Study: NCT06774547

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Plyometric exercise
Description: The progressive plyometric programme consists of three different levels and is performed unsupervised three times per week separated by a minimum of 48 hours. Each level consists of several exercise sets that are separated by 2-minute rest intervals. Participants' self-evaluated readiness to progress to a higher level will guide the progression. Level 1 includes free-standing double-legged plyometric exercises where they push off the ground and lift their heels while maintaining contact with it. If the participant feels they can do more, they will progress to Level 2, where participants increase the relative load during the dynamic exercises and start performing plyometric double-legged jumps. At the highest level, Level 3, the relative load during the exercises is further increased, and the plyometric exercises are to be performed as single-legged hops. Tolerable pain during the exercises is allowed.
Study: NCT05756725

Intervention type: OTHER
Group type: OTHER
Intervention: Practice-Level Implementation Strategies
Description: The intervention is implementation of new population health management tools that may better leverage patient navigation and other staff resources to ensure timely abnormal follow up of breast and colorectal cancer screening. The research team will work with CHCs to select implementation strategies that will best facilitate integration of the new tools into practice. The team will use electronic health record data (analyzed at the population level) to determine the impact of the new tools on screening outcomes and qualitative data from up to 3 staff and 2 patients per CHC to evaluate integration of the tools into practice.
Study: NCT04861337

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Remimazolam
Description: Remimazolam is infused at a rate of 0.25 mg/kg/h from end of anesthesia induction until 15 minutes before the end of surgery.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Normal saline is infused at a rate same as in the remimazolam group from end of anesthesia induction until 15 minutes before the end of surgery.
Study: NCT05670626

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Refractive Surgery
Description: Phakic implantable contact lens ( ICL)
Study: NCT06774651

Intervention type: PROCEDURE
Intervention: Procedure: Corneal lenticule extraction for advanced refractive correction (CLEAR)
Description: Routinely conducted procedure using FEMTO LDV Z8 laser system for correction of Myopia.

Intervention type: PROCEDURE
Intervention: Procedure: Small Incision Lenticule Extraction (SMILE)
Description: Routinely conducted procedure using VisuMax laser system for correction of Myopia.
Study: NCT06774573

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CBT-txt-A
Description: 8-week automated text-message delivered treatment for Generalized Anxiety Disorder
Study: NCT06774105

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Static Stretching
Description: The protocol consisted in 2 sessions per week, each comprising 8 exercises of static stretching targeting all major muscle groups: 1) Hamstrings, 2) Knee Extensors, 3) Dorsal muscles, 4) Pectoralis muscles, 5) Elbow Flexors (biceps), 6) Elbow Extensors (triceps), 7) Adductors, and one day 8a) Spine Extensors while the second 8b) Spine Flexors. Each exercise involved 4 sets of 30 seconds of SS and 30 seconds of rest.
Study: NCT06770920

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: use of an observer tool when not role-playing
Description: Observers will use an observer tool (based on technical skills and specifically related to airway management during BLS) when they will be not role role-playing.
Study: NCT06773091

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NK042
Description: NK042 is an allogeneic, off-the-shelf cellular therapy derived from healthy donors and enriched with NKR+ NK cells.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine (FLU)
Description: Fludarabine (FLU) is administered as a lymphodepletion regimen prior to NK042 infusion.
Study: NCT05374707

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MOTIVATIONAL INTERVIEWING
Description: Motivational interviewing is a form of interview conducted with a patient-centered approach in order to enable people to discover and solve the obstacles to behavior change.
Study: NCT06773091

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide (CTX)
Description: Cyclophosphamide (CTX) is administered as a lymphodepletion regimen prior to NK042 infusion.
Study: NCT05073055

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: İnguinal Hernia Repair
Description: After hemodynamic stability, the patient was placed in the lateral position and infiltration anesthesia with 2% lidocaine was applied. Following aseptic preparation of the skin and probe, a medium-frequency curvey USG transducer was first placed in the midline to visualize the transverse projection of the first lumbar (L1) vertebra, then moved 2.5 cm laterally in the parasagittal plane, after imaging the transverse process, in-plane spreading was injected. Hydrodissection was achieved on the TP of L1 by using a 5 cm, 21G peripheral nerve block needle just below the erector spina muscle with real-time imaging of the substance. Afterwards, a unilateral injection of 15 ml at T12 and L1 levels was applied to each segment with the needle directed at two different angles from the same insertion point.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: İnguinal Hernia Repair
Description: After hemodynamic stability, the patient was placed in the lateral position and infiltration anesthesia with 2% lidocaine was applied. Following aseptic preparation of the skin and probe, a medium-frequency curvey USG transducer was first placed in the midline to visualize the transverse projection of the first lumbar (L1) vertebra, then moved 2.5 cm laterally in the parasagittal plane, after imaging the transverse process, in-plane spreading was injected. Hydrodissection was achieved on the TP of L1 by using a 5 cm, 21G peripheral nerve block needle just below the erector spina muscle with real-time imaging of the substance. Afterwards, a unilateral injection of 15 ml at T12 and L1 levels was applied to each segment with the needle directed at two different angles from the same insertion point.
Study: NCT05422131

Intervention type: DEVICE
Intervention: MyCare Insite Clozapine Test
Description: The MyCare Insite Clozapine Test is a 2 reagent system designed to evaluate the level of antipsychotic drug clozapine in a patients blood using the near patient device the MyCare Insite Analyser.
Study: NCT04918342

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multidimensional Exercise Program
Description: The multidirectional exercise program will include cardiovascular training, strengthening, balance training, and flexibility training. This will be delivered 2 times per week for 8 weeks using telehealth and will be delivered by a physical therapist. The exercises will be modified to meet the participants needs. Intensity of exercise interventions will be monitored through patient self report and use of continuous heart rate monitoring.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Multidimensional Exercise Program
Description: The multidirectional exercise program will include cardiovascular training, strengthening, balance training, and flexibility training. This will be delivered 2 times per week for 8 weeks using telehealth and will be delivered by a physical therapist. The exercises will be modified to meet the participants needs. Intensity of exercise interventions will be monitored through patient self report and use of continuous heart rate monitoring.
Study: NCT04535219

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise
Description: 60 minutes of moderate-intensity treadmill exercise (70% of maximal heart rate determined from the maximal graded exercise test)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supervised Total Sleep Deprivation
Description: Laboratory-monitored total sleep deprivation
Study: NCT06770985

Intervention type: OTHER
Intervention: Artificial Intelligence
Description: Ollama (Ollama., 2024, https://ollama.ai/) artificial intelligence program and PYTHON 3 Programming Language and open source libraries will be used for the necessary algorithms for data review and analysis. In case of deficiencies in the data of the patients; the missing data will be edited using Data Imputation techniques. Number of files to be reviewed and/or date range to be covered: Patients who underwent lung resection between January 2023 and October 2024 will be included. An estimated 2000 files are planned to be scanned.
Study: NCT06773988

Intervention type: DIAGNOSTIC_TEST
Intervention: Monitoring of NIV at home
Description: Monitoring of NIV at home
Study: NCT06772597

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Setmelanotide
Description: Setmelanotide (daily subcutaneous injection)
Study: NCT06053801

Intervention type: OTHER
Intervention: Xolair
Description: Prospective observational cohort study. There is no treatment allocation. Patients administered Xolair by prescription will be enrolled.
Study: NCT05853055

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Respiratory training
Description: Respiratory training will be included in the rehabilitation program of a subgroup of post-COVID-19 patients. The intervention group will train twice daily for the length of their rehabilitation stay using an incentive spirometer (Voldyne 5000 R, Sherwood Medical, St. Louis, USA). Subjects will be instructed to first completely exhale slowly. Then inspire slowly up to 70% of their vital capacity, producing a constant flow controlled via feedback from the device. This procedure will be repeated every 30 s (paced by a metronome) for 15 min. The training will be conducted twice a day, resulting in a total of 60 inspirations per day.
Study: NCT05665049

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Social Transfer
Description: Social transfers are defined as a cash or in-kind transfer. Using results from a qualitative study, we identified the following culturally grounded social transfer options that is responsive to the identified needs of new mothers. Based on the monthly Lao PDR minimum wage and an estimated 15 full working days needed to exclusively breastfeed over a 6-month period, a social transfer of approximately $75 would fairly subsidize women's breastfeeding efforts. Therefore all social transfer options equate to approximately 75 USD. The options include: diapers, child developmental toys, cash, or a combination of these.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Social Transfer
Description: Social transfers are defined as a cash or in-kind transfer. Using results from a qualitative study, we identified the following culturally grounded social transfer options that is responsive to the identified needs of new mothers. Based on the monthly Lao PDR minimum wage and an estimated 15 full working days needed to exclusively breastfeed over a 6-month period, a social transfer of approximately $75 would fairly subsidize women's breastfeeding efforts. Therefore all social transfer options equate to approximately 75 USD. The options include: diapers, child developmental toys, cash, or a combination of these.
Study: NCT04535219

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supervised Total Sleep Deprivation
Description: Laboratory-monitored total sleep deprivation
Study: NCT04557384

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ramucirumab
Description: Administered SC
Study: NCT06300515

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control Group (Active Comparator)
Description: During the intervention phase (hospitalization for HSCT and subsequent 8-week outpatient phase following discharge), the control group will participate in a Health Counseling Program (1 time/week) on aspects related to a healthy lifestyle such as reducing sedentary lifestyle, acquiring healthy nutritional habits, the importance sleep, screen use, and how to address barriers related to clinical status. We will adapt the program to the needs and timing of the patient's treatment, providing the content in one session/week orally (e.g. using presentations) and in writing (e.g. through brochures).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention Group
Description: Same as Control Group + exercise program as described below:~Same as Control Group + exercise program as described below:~Hospital ward (during HSCT); and Hospital Gym or online (patients' home) during the outpatient phase. Frequency: 3-5 days/week. Session duration: 30 to 55-60 minutes Aerobic training (5-25 minutes): bicycling, crank-ergometry, circuit-style exercises, and games. Muscle strength training (10-20 minutes): large muscle group exercises (upper/lower limb + trunk exercises) performed as a circuit using body weight or against resistance (against gravity and with body weight, elastic bands, dumbbells, weighted vests, machines), with a wide range of joint mobility and at submaximal/maximum voluntary speed. Inspiratory muscle training will also be performed (5 min daily, using a specific device that creates resistance against inspiration).
Study: NCT02312570

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: PRP Concepts Fibrin Bio-Matrix
Description: Administration of PRP Concepts Fibrin Bio-Matrix to wound in addition to usual and customary care

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Usual and Customary Practice
Description: Ussual and customary care of non-healing pressure wounds

Intervention type: OTHER
Group type: OTHER
Intervention: Usual and Customary Practice
Description: Ussual and customary care of non-healing pressure wounds
Study: NCT05773677

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Specific Diet
Description: A specific diet will be developed for each patient, which will also take into account any food allergies or intolerances.~Each diet will be then eventually modified and revised throughout the pregnancy, according to the evolution of the same.
Study: NCT05858190

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Parallel Assignment
Description: intervention group: treated with drug eluting balloon（paclitaxel-coated balloon； Orchid, Acotec Scientific Holdings Limited, Beijing, China)； control group :treated with plain old balloon

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Parallel Assignment
Description: intervention group: treated with drug eluting balloon（paclitaxel-coated balloon； Orchid, Acotec Scientific Holdings Limited, Beijing, China)； control group :treated with plain old balloon
Study: NCT06236347

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Smoking cessation e-visit
Description: Electronic visits (e-visits) for smoking cessation
Study: NCT05436665

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: UT-DSAEK
Description: The main incision (3.5-5mm) is created at the corneal limbus or via a cornea-scleral tunnel with 2-3 smaller (approx. 1mm) paracentesis incisions. An ophthalmic viscosurgical device (OVD) or a continuous infusion of water or air can be used to maintain the stability of the anterior chamber, according to the surgeon's preference. The corneal endothelium is scored using a scoring instrument and the central diseased corneal endothelium is removed. Once the anterior chamber is prepared, OVD or air has been removed, then the eye is ready for the new corneal graft.~The pre-cut corneal tissue delivered by the bank is then gently rinsed and may be stained with 0.06% trypan blue if required. The tissue is loaded into a glide or injector, and pulled into the anterior chamber using a smooth-tipped micro-forceps (e.g., Busin forceps). Once the graft enters the eye, it is lifted to the posterior cornea. The graft is further centred using air (or SF6 Gas) in the anterior chamber.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: DMEK
Description: The main incision (2.8-3mm) is created superior or temporally at the corneal limbus and is accompanied by 2-3 smaller paracentesis incisions. An ophthalmic viscosurgical device (OVD) or a continuous infusion of water or air can be used to maintain the stability of the anterior chamber. The corneal endothelium is scored using a scoring instrument and the central diseased corneal endothelium is removed.~The DMEK roll is poured into a basin and rinsed. The graft is then stained with 0.06% trypan blue to aid in graft visualization. The graft is loaded into an injector and introduced into the anterior chamber. The graft is unrolled using external manoeuvres and once unrolled, it is lifted to the back of the cornea. The eye is then pressurised with a full air fill from 10 to 120 minutes. The pressure is then reduced and the case is completed by suturing any incisions required.
Study: NCT04079855

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Diet composition 1
Description: A diet with a specified macronutrient composition different from arms 2 and 3.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Diet composition 2
Description: A diet with a specified macronutrient composition different from arms 1 and 3.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Diet composition 3
Description: A diet with a specified macronutrient composition different from arms 1 and 2, based on the current information about the US macronutrient composition.
Study: NCT05285904

Intervention type: OTHER
Intervention: Ofatumumab
Description: Prospective observational cohort study. There is no treatment allocation. Patients administered Ofatumumab, that have started before inclusion of the patient into the study will be enrolled.
Study: NCT06422936

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BO-112
Description: Noncoding double-stranded (ds) RNA based on polyinosinic-polycytidylic acid (Poly I:C), formulated with polyethylenimine (PEI) for intra-lesional injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BO-112
Description: Noncoding double-stranded (ds) RNA based on polyinosinic-polycytidylic acid (Poly I:C), formulated with polyethylenimine (PEI) for intra-lesional injection
Study: NCT05565092

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALXN1820
Description: ALXN1820 will be administered subcutaneously.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALXN1820
Description: ALXN1820 will be administered subcutaneously.
Study: NCT06236347

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as usual
Description: Information about the state quitline and about the importance of quitting smoking and a recommendation to contact one's PCP to schedule a medical visit to discuss quitting smoking.
Study: NCT05565092

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALXN1820
Description: ALXN1820 will be administered subcutaneously.
Study: NCT04963296

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Obinutuzumab
Description: Obinutuzumab will be administered by IV infusion at a dose of 1000 mg on Day 1 and at Weeks 2, 24 and 26.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo matching obinutuzumab will be administered by IV on Day 1 and at Weeks 2, 24 and 26.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Acetaminophen/Paracetamol
Description: Acetaminophen 650-1000 mg will be administered as premedication prior to infusions.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Acetaminophen/Paracetamol
Description: Acetaminophen 650-1000 mg will be administered as premedication prior to infusions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Diphenhydramine hydrochloride
Description: Diphenhydramine 50 mg will be administered as premedication prior to infusions.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Diphenhydramine hydrochloride
Description: Diphenhydramine 50 mg will be administered as premedication prior to infusions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methylprednisolone
Description: Methylprednisolone 80 mg IV will be administered as premedication prior to infusions.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Methylprednisolone
Description: Methylprednisolone 80 mg IV will be administered as premedication prior to infusions.
Study: NCT05752487

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Pulsed Field (PF) /Radiofrequency (RF) Catheter ablation
Description: Participants will undergo catheter ablation with the PF /RF ablation system consisting of the TRUPULSE Generator (delivers RF or PF energy through the study catheter) and the THERMOCOOL SMARTTOUCH SF (STSF) Catheter (indicated for use in catheter-based cardiac electrophysiological mapping (stimulating and recording) and, when used with a Generator, for cardiac ablation).