Study: NCT05088356

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Purified regulatory T-cells (Treg) plus CD34+ HSPC
Description: Purified regulatory T-cells (Treg) plus CD34+ hematopoietic progenitor cells (CD34+ HSPC), followed by conventional T-cells (Tcon) Manufactured at SCTT Laboratory, dose 1x10\^6 cells/ kg to 3x10\^6 cells/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Purified regulatory T-cells (Treg) plus CD34+ HSPC
Description: Purified regulatory T-cells (Treg) plus CD34+ hematopoietic progenitor cells (CD34+ HSPC), followed by conventional T-cells (Tcon) Manufactured at SCTT Laboratory, dose 1x10\^6 cells/ kg to 3x10\^6 cells/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Purified regulatory T-cells (Treg) plus CD34+ HSPC
Description: Purified regulatory T-cells (Treg) plus CD34+ hematopoietic progenitor cells (CD34+ HSPC), followed by conventional T-cells (Tcon) Manufactured at SCTT Laboratory, dose 1x10\^6 cells/ kg to 3x10\^6 cells/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Purified regulatory T-cells (Treg) plus CD34+ HSPC
Description: Purified regulatory T-cells (Treg) plus CD34+ hematopoietic progenitor cells (CD34+ HSPC), followed by conventional T-cells (Tcon) Manufactured at SCTT Laboratory, dose 1x10\^6 cells/ kg to 3x10\^6 cells/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Purified regulatory T-cells (Treg) plus CD34+ HSPC
Description: Purified regulatory T-cells (Treg) plus CD34+ hematopoietic progenitor cells (CD34+ HSPC), followed by conventional T-cells (Tcon) Manufactured at SCTT Laboratory, dose 1x10\^6 cells/ kg to 3x10\^6 cells/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Purified regulatory T-cells (Treg) plus CD34+ HSPC
Description: Purified regulatory T-cells (Treg) plus CD34+ hematopoietic progenitor cells (CD34+ HSPC), followed by conventional T-cells (Tcon) Manufactured at SCTT Laboratory, dose 1x10\^6 cells/ kg to 3x10\^6 cells/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Fludarabine (160 mg/m2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Fludarabine (160 mg/m2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Fludarabine (160 mg/m2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Fludarabine (160 mg/m2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Fludarabine (160 mg/m2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Fludarabine (160 mg/m2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Melphalan
Description: Melphalan (50 mg/m2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Melphalan
Description: Melphalan (50 mg/m2)

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CliniMACS CD34 Reagent System
Description: The CliniMACS® CD34 Reagent System is a medical device that is used in vitro to select and enrich specific cell populations is manufactured by Miltenyi Biotec

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tacrolimus
Description: 4-6ng/mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tacrolimus
Description: 4-6ng/mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tacrolimus
Description: 4-6ng/mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tacrolimus
Description: 4-6ng/mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tacrolimus
Description: 4-6ng/mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tacrolimus
Description: 4-6ng/mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: 40mg/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plerixafor
Description: Dose 0.24 mg/kg, manufactured by Genzyme

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plerixafor
Description: Dose 0.24 mg/kg, manufactured by Genzyme

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plerixafor
Description: Dose 0.24 mg/kg, manufactured by Genzyme

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plerixafor
Description: Dose 0.24 mg/kg, manufactured by Genzyme

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plerixafor
Description: Dose 0.24 mg/kg, manufactured by Genzyme

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plerixafor
Description: Dose 0.24 mg/kg, manufactured by Genzyme

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Filgrastim granulocyte colony-stimulating factor (G-CSF) or equivalent
Description: Single-use vials contain either 300 mcg or 480 mcg filgrastim at a fill volume of 1.0 mL or 1.6 mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Filgrastim granulocyte colony-stimulating factor (G-CSF) or equivalent
Description: Single-use vials contain either 300 mcg or 480 mcg filgrastim at a fill volume of 1.0 mL or 1.6 mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Filgrastim granulocyte colony-stimulating factor (G-CSF) or equivalent
Description: Single-use vials contain either 300 mcg or 480 mcg filgrastim at a fill volume of 1.0 mL or 1.6 mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Filgrastim granulocyte colony-stimulating factor (G-CSF) or equivalent
Description: Single-use vials contain either 300 mcg or 480 mcg filgrastim at a fill volume of 1.0 mL or 1.6 mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Filgrastim granulocyte colony-stimulating factor (G-CSF) or equivalent
Description: Single-use vials contain either 300 mcg or 480 mcg filgrastim at a fill volume of 1.0 mL or 1.6 mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Filgrastim granulocyte colony-stimulating factor (G-CSF) or equivalent
Description: Single-use vials contain either 300 mcg or 480 mcg filgrastim at a fill volume of 1.0 mL or 1.6 mL

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thiotepa
Description: Thiotepa 10 mg/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thiotepa
Description: Thiotepa 10 mg/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thiotepa
Description: Thiotepa 10 mg/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thiotepa
Description: Thiotepa 10 mg/kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mycophenolate Mofetil (MMF)
Description: MMF 1000 mg BID

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ruxolitinib
Description: Ruxolitinib 5 mg BID