TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05636787

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Treosulfan
Description: Efficacy of standard treatment melphalan will be compared to the combination melphalan with treosulfan

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Melphalan
Description: Efficacy of standard treatment melphalan will be compared to the combination melphalan with treosulfan

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Melphalan
Description: Efficacy of standard treatment melphalan will be compared to the combination melphalan with treosulfan
Study: NCT03994770

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Balanced Reach Assessment and Training Protocol
Description: Three one-hour training sessions for one week in the Balanced Reach Training Protocol
Study: NCT05069545

Intervention type: DRUG
Intervention: Insulin degludec
Description: Introducing a NovoPen® 6 to patients with type 1 diabetes mellitus (T1DM), who are already being treated with Tresiba® and Fiasp®

Intervention type: DRUG
Intervention: Fast-acting insulin aspart
Description: Introducing a NovoPen® 6 to patients with type 1 diabetes mellitus (T1DM), who are already being treated with Tresiba® and Fiasp®
Study: NCT06181292

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PHH-1V81
Description: booster of PHH-1V81

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Comirnaty Omicron XBB1.5
Description: booster of Comirnaty Omicron XBB1.5
Study: NCT06501820

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial direct current stimulation
Description: 2mA transcranial direct current stimulation, applied bilaterally on the scalp, over the brain vestibular cortex

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcranial direct current stimulation
Description: 2mA transcranial direct current stimulation, applied bilaterally on the scalp, over the brain vestibular cortex
Study: NCT05299944

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cannabidiol
Description: The current study will directly test the hypothesis that a moderate dose of CBD leads to a reduction in opioid consumption, opioid craving, pain, peripheral markers of inflammation, and anxiety, as well as changes in sleep, AEA, and cognition.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cannabidiol
Description: The current study will directly test the hypothesis that a moderate dose of CBD leads to a reduction in opioid consumption, opioid craving, pain, peripheral markers of inflammation, and anxiety, as well as changes in sleep, AEA, and cognition.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo arm
Study: NCT06494332

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise and stretching programe
Description: It consists in: a serie of mobility exercises, which were used as warp-up; the mobility of the elbow, forearm, wrist and fingers of both upper limbs was worked on; and, exercises were performed to strengthen the muscles of both forearms.
Study: NCT05088590

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Enfagrow® Neuropro Toddler Nutritional Drink
Description: Enfagrow® Neuropro Toddler Nutritional Drink to be consumed per day (equivalent to 40 mL per kg, rounded to the nearest ounce)

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Pediasure® Grow & Gain Protein Shake for Kids
Description: Pediasure® Grow \& Gain Protein Shake for Kids to be consumed per day (equivalent to 40 mL per kg, rounded to the nearest ounce)
Study: NCT06647784

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pulmonary aeration in supine and ventral decubitus
Description: The addition of repeated periods of 30 minutes of lateralization of 30° amplitude in dorsal decubitus and in ventral decubitus in patients with moderate to severe ARDS. Included patients will benefit from sessions of lateral decubitus for 30 minutes on each side (with an inclination of 30°) with alternation12 right/left, repeatedly for 6 hours. During this period, the upper part of the bed will be inclined by 30°. Patients will then be positioned in strict prone position for a period of 6 hours after which, the same pattern of alternating lateral decubitus will be applied for 12 hours while the patient is still in the prone position. After reversal in supine position, an observation period of 1 hour will be respected before carrying out the last measurements. The total duration of the intervention will be 25 hours.
Study: NCT06648967

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Supplementation with a multi-ingredient whey supplement
Description: Malabsorption of two different fructose boluses at baseline and after 3 and 5 weeks of multi-ingredient whey supplementation.
Study: NCT06649422

Intervention type: DRUG
Intervention: Blinatumomab
Description: The 14-day blinatumomab combined with reduced-dose chemotherapy is used for the induction treatment of newly diagnosed Ph-chromosome negative acute B-lymphoblastic leukemia.
Study: NCT06545656

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doxycycline
Description: Doxycycline (DOX) will be given orally at 100mg doses. Participants will take the study medication for 7 consecutive days.
Study: NCT06514716

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Geniculate Artery Embolization with Intra-articular Corticosteroid Injection (GAE with IACI)
Description: Participants will undergo geniculate artery embolization (GAE) followed by an intraoperative intra-articular corticosteroid injection (IACI). This combination aims to alleviate post-procedural pain and improve early functional outcomes in patients with knee osteoarthritis (OA).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Geniculate Artery Embolization alone (GAE alone)
Description: Participants will undergo geniculate artery embolization (GAE) without the additional intraoperative intra-articular corticosteroid injection. This procedure aims to serve as a control to evaluate the effectiveness and safety of GAE with IACI in comparison.
Study: NCT05928884

Intervention type: OTHER
Intervention: There is no intervention. It is a phenotyping study only
Description: See above, this is only a phenotyping study but NIH required us to register it as a trial.

Intervention type: OTHER
Intervention: There is no intervention. It is a phenotyping study only
Description: See above, this is only a phenotyping study but NIH required us to register it as a trial.

Intervention type: OTHER
Intervention: There is no intervention. It is a phenotyping study only
Description: See above, this is only a phenotyping study but NIH required us to register it as a trial.

Intervention type: OTHER
Intervention: There is no intervention. It is a phenotyping study only
Description: See above, this is only a phenotyping study but NIH required us to register it as a trial.
Study: NCT06041308

Intervention type: OTHER
Intervention: valve
Description: bioprothetic valve versus mechanical valve

Intervention type: OTHER
Intervention: valve
Description: bioprothetic valve versus mechanical valve
Study: NCT06247384

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Hypotension Prediction Index Hemodynamic Monitoring
Description: The application of the perioperative hemodynamic management according to the hypotension prediction index algorithm.
Study: NCT04532645

Intervention type: DRUG
Intervention: Olaparib
Description: Olaparib
Study: NCT05249322

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Follow-up alternating between face-to-face consultation and teleconsultation every three months.
Description: The intervention will be an alternate follow-up every three months with:~* A tele-consult: with paramedical consult (with assistance for home-spirometry) and medical consult for about 1h30 in total, make with a HCL platform for telemedicine.~* An usual in-hospital consult of about 1h30 with paramedical and medical consult.
Study: NCT04676958

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Vitamin K2
Description: Vitamin K2

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Micro-crystalline cellulose
Description: Micro-crystalline cellulose
Study: NCT05630521

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Medication Adherence Problem Solving for Hypertension
Description: The MASH program is a 12-week intervention containing two components: (1) four education modules on HTN causes, risks, treatment, and barriers to treatment; and (2) telehealth visits every 2 weeks with a registered nurse to deliver evidence-based managed problem solving strategies tailored on patients' responses to assessments of HTN beliefs, medication beliefs, and barriers impacting their medication adherence.
Study: NCT05438030

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Cardiac MRI scan
Description: Undertaken at the radiology department at Hammersmith Hospital. The scan will be performed by the MRI radiographers, under the supervision of a consultant radiologist or cardiologist.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Echocardiogram scan
Description: Undertaken at the Peart Rose research unit, by a British Society of Echocardiography accredited sonographer.
Study: NCT06241690

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: the cold applications in post-suture pain reduces the child's pain
Description: The experimental groups was applied cold applications immediately after 20 minutes the suture. Later, The experimental groups was applied cold applications again for 20 minutes 1 hour, 2 hours and 6 hours after the suture.
Study: NCT06306950

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Near infrared spectroscopy neuromonitor to prevent cerebral desaturation
Description: patients were assigned into active treatment (intervention) or usual care (control) groups with cerebral oximetry monitoring using NIRS bilaterally (Root; Prime Medical Corporation, MASIMO, USA) \[17\]. After cleansing the adjacent skin area with alcohol, an adhesive optode pad was placed over each frontal to temporal area. Resting baseline rSO2 values were obtained after waiting at least 1 minute after the placement of the sensors.
Study: NCT04878419

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Educational Program
Description: Multiple virtual interactive sessions to provide education/knowledge about Type 1 Diabetes Mellitus care
Study: NCT06080932

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ketogenic Diet
Description: The diet intervention will start after all baseline testing is complete
Study: NCT06646718

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Close kinetic chain exercise group
Description: ●Close kinetic chain exercise group: group A will receive forward step-ups, lateral step-ups, squats, sit-to-stand, and stoop-and-recover exercises. session will be initiated with a 10 min warm-up period, including stretching of the major muscles and muscle groups, then 40 min different exercises and terminated with a 10 min cool-down period in the form of aerobic exercises.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Traditional physical therapy.
Description: ●Traditional physiotherapy: group B will receive stretching for the lower extremity muscles, namely hip flexors and adductors, hamstrings, and calf muscles; and strengthening exercises for core muscles, hip extensors, flexors and abductors, internal and external rotators of the hip, flexors and extensors of the knee, ankle dorsi flexors, kneeling exercises, and standing and gait training
Study: NCT06646796

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Yoga
Description: Yoga with certified teacher, 3 times a week during 3 months.
Study: NCT06645613

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcranial Magnetic Stimulation Device
Description: Transcranial magnetic stimulation uses FDA-approved coils to generate varying magnetic fields in the brain of the participant and induce an electric field in the underlying brain tissue. The standard intermittent Theta Burst Stimulation (iTBS) TMS protocol will be applied in this study. The same coil can be applied to generate sham stimulations that only generate sound and stimulations to the scalp without stimulating the brain.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulation Device
Description: Transcranial magnetic stimulation uses FDA-approved coils to generate varying magnetic fields in the brain of the participant and induce an electric field in the underlying brain tissue. The standard intermittent Theta Burst Stimulation (iTBS) TMS protocol will be applied in this study. The same coil can be applied to generate sham stimulations that only generate sound and stimulations to the scalp without stimulating the brain.
Study: NCT04855110

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Warfarin Sodium started on Day 2 after caesarean section (in a dose that achieves a therapeutic level as indicated by the cardiology consultant)
Description: Warfarin started on day 2 after caesarean section in patients with mechanical heart valve prosthesis

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Warfarin Sodium started on day 5 after caesarean section (in a dose that achieves a therapeutic level as indicated by the cardiology consultant)
Description: Warfarin started on day 5 after caesarean section in patients with mechanical heart valve prosthesis
Study: NCT06108115

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CueToSleep (Full Intervention Package)
Description: Individuals will be randomly allocated to receive the full Health Rhythms package (CueToSleep) program on their smartphones. The package includes 24/7 behavioral sensing from the participant's smartphone using the global positioning system, accelerometer, and screen on/off state, as well as a series of psychoeducational learning screens about the relationship among alcohol, mood disturbance and sleep, and personalized suggestions for behavior change to improve sleep that will be sent to the participant every 3 to 4 days. These suggestions will be based on behaviors indicated by the individual participant's sensor data over the previous 3 to 4 days.
Study: NCT06421909

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: mindfulness-based educational intervention
Description: Mindfulness-based educational intervention is a structured program that incorporates principles of mindfulness to help individuals develop greater awareness and acceptance of their thoughts, feelings, and bodily sensations. The intervention typically includes mindfulness meditation practices, cognitive-behavioral techniques, and educational components about stress management and emotional regulation. By fostering a non-judgmental and present-focused attitude, participants learn to manage their symptoms more effectively and improve their overall quality of life.
Study: NCT06115850

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Music
Description: In the music intervention group, the patients received music intervention during RT for 10 consecutive days and listened to music for approximately 10-15 minutes in each session.
Study: NCT04674774

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tegoprazan
Description: oral administration of tegoprazan-based bismuth quadruple therapy(tegoprazan 50 mg b.i.d, bismuth 300 mg q.i.d, metronidazole 500 mg t.i.d, tetracycline 500 mg q.i.d) for 14 days
Study: NCT06444464

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Aerobic exercise
Description: After baseline 24-hour blood pressure measurements are taken at visit 2, participants will attend a final study visit where they will engage in a single session of aerobic exercise. The exercise routines will include 5 to 10-minute warm-up and cool-down periods, along with a 30-minute workout. Twenty-four hour blood pressure measurements will be taken after the exercise bout.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Isometric exercise
Description: After baseline 24-hour blood pressure measurements are taken at visit 2, participants will attend a final study visit where they will engage in a single session of isometric exercise. The exercise routines will include 5 to 10-minute warm-up and cool-down periods, along with a 30-minute workout. Twenty-four hour blood pressure measurements will be taken after the exercise bout.
Study: NCT05492006

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Indirect contact with nature
Description: The participants will watch a video with validated images of nature from e-Nature Positive Emotions Photography Database (e-NatPOEM). Four fifteen-minute sessions will be held on four consecutive days, totaling 1 hour.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Intentional contact with nature
Description: The participants will take a light walk in a park with green spaces guided by research team in a single 1-hour session, with an emphasis on sense-directed appreciation.
Study: NCT05613608

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cannabidiol
Description: The current study will directly test the hypothesis that a moderate dose of CBD leads to a reduction in alcohol consumption, alcohol craving, peripheral markers of inflammation, and anxiety.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cannabidiol
Description: The current study will directly test the hypothesis that a moderate dose of CBD leads to a reduction in alcohol consumption, alcohol craving, peripheral markers of inflammation, and anxiety.
Study: NCT04674774

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Lansoprazole
Description: oral administration of PPI-based bismuth quadruple therapy(lansoprazole 30 mg b.i.d, bismuth 300 mg q.i.d, metronidazole 500 mg t.i.d, tetracycline 500 mg q.i.d) for 14 day
Study: NCT05728593

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: parent-based occupational therapy
Description: Parent-based occupational therapy intervention While the therapist, parent and child were in the therapy area in the first session, the child received the same standard occupational intervention as the control group, and during this process, the parents recorded the therapy with a video recorder. In the second 20 minutes, three activities (such as eating, dressing or mobility activities), which had been decided and planned by the parent and the therapist before the session, were performed by the child and helped by the parent and video-recorded by the occupational therapist.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard occupational therapy intervention
Description: The sessions in this intervention included the creation of a client-based programme to increase each child's individual skills, functions and social participation. Each session lasted 45 minutes and took place twice a week until 10 sessions had been completed.~Various materials such as toys, blocks, paper and pencils were used to increase the child's participation in daily living, leisure and play activities.
Study: NCT05613608

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo arm.
Study: NCT06137638

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ENA-001
Description: ENA-001 will be prepared in Ringer's lactate solution. A loading dose will be administered for 20 minutes followed by continuous infusion until the patient meets the criteria for PACU discharge (≥ 9 Aldrete score) or ABG reveals PaCO2 \< 30 mmHg with pH in the normal range. ENA-001 is for IV injection ready for use per subject by the investigational pharmacy, according to the randomization schedule.
Study: NCT06295614

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ARC-IM System implantation
Description: Implantation of a stimulation lead on the lumbar level of the spinal cord and implantation of a neurostimulator in the abdominal region.
Study: NCT06137638

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: ENA-001
Description: ENA-001 will be prepared in Ringer's lactate solution. A loading dose will be administered for 20 minutes followed by continuous infusion until the patient meets the criteria for PACU discharge (≥ 9 Aldrete score) or ABG reveals PaCO2 \< 30 mmHg with pH in the normal range. ENA-001 is for IV injection ready for use per subject by the investigational pharmacy, according to the randomization schedule.
Study: NCT05484583

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab + carboplatin/cisplatin + etoposide
Description: Induction period (3 weeks as a cycle, 4 cycles of administration): Durvalumab + carboplatin/cisplatin + etoposide, intravenous drip

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Consolidation radiotherapy
Description: Consolidation radiotherapy period: radiotherapy for primary chest lesions + oligometastatic lesions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab
Description: Maintenance phase (administered every 4 weeks): Durvalumab intravenous infusion
Study: NCT06208345

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Life-Style app
Description: The modules of the Life-Style app are introduced and unlocked sequentially during the first weeks of the intervention phase. Afterwards the modules are fully available. Duration and frequency of app-use is not limited. The parents are accompanied by a coach through the app, who gives regular structured feedback and individual inputs. The coach has access to all data collected in the app.
Study: NCT05854212

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral economics-enhanced user interface
Description: The intervention changes the ordering platform visible to food agencies using behavioral economics strategies to promote healthier food choices.
Study: NCT03693105

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Active SAINT Stimulation
Description: Participants who are randomly assigned to this group will receive active SAINT targeted to the left DLPFC. Stimulation intensity will be standardized at 90% of resting motor threshold (adjusted for cortical depth).~Stimulation will be delivered using the Magventure Magpro X100 TMS system with the Cool-B65 A/P coil.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham SAINT Stimulation
Description: Participants who are randomly assigned to this group will receive sham stimulation targeted to the left DLPFC.~Sham stimulation will be delivered using the Magventure Magpro X100 TMS system with the Cool-B65 A/P coil.
Study: NCT06649240

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Statins and/or Ezetimibe
Description: Statin ± Ezetimibe to achieve target LDL-cholesterol level

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Statins and/or Ezetimibe
Description: Statin ± Ezetimibe to achieve target LDL-cholesterol level