TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05835492

Intervention type: DEVICE
Intervention: myCOPD
Description: myCOPD is a digital self-management application (app), that supports all elements of managing COPD by creating a supported self-help environment, and in turn reduce medical visits, and hospital admissions and re-admissions. myCOPD allows for key aspects of disease management, such as PR, to be provided remotely, based on a person's self-assessment. Furthermore, it can help people with COPD manage their condition at home, or anywhere away from a clinical setting. Successful implementation of myCOPD provides an opportunity to build capacity in primary and secondary care, and community teams where a blended approach with traditional PR and myCOPD is used. Studies have shown myCOPD is able to deliver similar improvements in symptoms and exercise tolerance compared to PR exercise-classes and helps patients admitted to hospital recover more quickly at home(5)(6). myCOPD is widely deployed across the NHS and is being used by patients in different areas of the UK.

Intervention type: DEVICE
Intervention: myCOPD
Description: myCOPD is a digital self-management application (app), that supports all elements of managing COPD by creating a supported self-help environment, and in turn reduce medical visits, and hospital admissions and re-admissions. myCOPD allows for key aspects of disease management, such as PR, to be provided remotely, based on a person's self-assessment. Furthermore, it can help people with COPD manage their condition at home, or anywhere away from a clinical setting. Successful implementation of myCOPD provides an opportunity to build capacity in primary and secondary care, and community teams where a blended approach with traditional PR and myCOPD is used. Studies have shown myCOPD is able to deliver similar improvements in symptoms and exercise tolerance compared to PR exercise-classes and helps patients admitted to hospital recover more quickly at home(5)(6). myCOPD is widely deployed across the NHS and is being used by patients in different areas of the UK.
Study: NCT05854940

Intervention type: DIAGNOSTIC_TEST
Intervention: Serum Raman spectroscopy intelligent diagnostic system
Description: Intelligent diagnostic system based on Raman spectrum of serum
Study: NCT05435183

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Non-invasive high-frequency oscillatory ventilation
Description: Non-invasive high-frequency oscillatory ventilation generates high-frequency pressure fluctuations in the airway caused by the opening and closing of a solenoid valve.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Noninvasive Bilevel Positive Pressure Ventilation
Description: Noninvasive Bilevel Positive Pressure Ventilation
Study: NCT06349785

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: rehabilitation of mechanically ventilated patients
Description: 1. mechanical ventilation~2. silicon resuscitation bag (500ml) connected to pressure manometer with an oxygen flow of 10 l.min-1~3. Endotracheal closed suction with pressure control ventilation (PCV)

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: supportive care
Description: - Children in study group B will receive standard Physical therapy program including suction, percussion and vibration with total duration of session in group a will be 15 minutes, daily for successive two weeks

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: supportive care
Description: - Children in study group B will receive standard Physical therapy program including suction, percussion and vibration with total duration of session in group a will be 15 minutes, daily for successive two weeks
Study: NCT06780020

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Effects of different interventions using boxing
Description: The programs were designed to consist of 8 weeks (16 sessions) with a warm-up consisting of joint mobility and low-intensity aerobic activities, a 40-minute core component BOX and a 10-minute cool-down with static flexibility exercises.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Effects of different interventions using taekwondo
Description: The programs were designed to consist of 8 weeks (16 sessions) with a warm-up consisting of joint mobility and low-intensity aerobic activities, a 40-minute core component TKD and a 10-minute cool-down with static flexibility exercises.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Effects of different interventions using Elastic Band
Description: The programs were designed to consist of 8 weeks (16 sessions) with a warm-up consisting of joint mobility and low-intensity aerobic activities, a 40-minute core component Elastic Band and a 10-minute cool-down with static flexibility exercises.
Study: NCT05151133

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Low dose UCMSCs
Description: Receive one course of treatment with a single injection : 0.5×10\^6 cells/kg, with a total volume of 100 ml UCMSCs;

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Moderate dose UCMSCs
Description: Receive one course of treatment with a single injection : 1.0×10\^6 cells/kg, with a total volume of 100 ml UCMSCs;

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: High dose UCMSCs
Description: Receive one course of treatment with a single injection : 2.0×10\^6 cells/kg, with a total volume of 100 ml UCMSCs;
Study: NCT05925270

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: mhGAP-Remote
Description: One in-person session followed by standardized SMSs to reinforce the concepts learned in the first session. The intervention follows principles of the World Health Organization's Mental Health Gap Action Programme (mhGAP). Study interventionists can provide telephonic support to participants to implement the skills.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: mhGAP-Standard
Description: Four in-person sessions with up to two booster sessions following the principles of World Health Organization's Mental Health Gap Action Programme (mhGAP).
Study: NCT04925921

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SR-1 Laser
Description: 3-4 treatments at 4-6 week intervals
Study: NCT06529783

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Shockwave Therapy
Description: The proposed model for radial shockwave therapy at Clínica Osteopática Dr. David Ponce is the DolorClast® by EMS, made in Nyon, Switzerland. Treatment parameters include 2500 impulses, 0.2 mJ/mm² energy density, and 15 pulses per second, using a 15 mm diameter applicator with ultrasound gel applied to the treatment area. The patient will be positioned laterally on the table with specific leg positions to ensure comfort and effectiveness.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Shockwave Therapy
Description: The proposed model for radial shockwave therapy at Clínica Osteopática Dr. David Ponce is the DolorClast® by EMS, made in Nyon, Switzerland. Treatment parameters include 2500 impulses, 0.2 mJ/mm² energy density, and 15 pulses per second, using a 15 mm diameter applicator with ultrasound gel applied to the treatment area. The patient will be positioned laterally on the table with specific leg positions to ensure comfort and effectiveness.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Therapeutic Exercises
Description: The exercise protocol was followed daily, with continuous physiotherapist supervision to ensure correct execution and avoid improper postures. The protocol includes four exercises: bilateral low-load supine abduction, unilateral isometric hip abduction in medial rotation, hip abduction with sliding, and bilateral supported glute bridge. A maximum of 4/10 on the VAS pain scale is allowed during exercise; exceeding this threshold means skipping exercises for that day.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Therapeutic Exercises
Description: The exercise protocol was followed daily, with continuous physiotherapist supervision to ensure correct execution and avoid improper postures. The protocol includes four exercises: bilateral low-load supine abduction, unilateral isometric hip abduction in medial rotation, hip abduction with sliding, and bilateral supported glute bridge. A maximum of 4/10 on the VAS pain scale is allowed during exercise; exceeding this threshold means skipping exercises for that day.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ultrasound-Guided Percutaneous Neuromodulation:
Description: This technique was applied only to the experimental group before shockwave therapy. An ultrasound-guided approach to the superior gluteal nerve used a 7-12 MHz linear probe from Esaote MyLab™Alpha and Physio Invasiva® equipment. The needle length varied with patient anatomy, with a typical safety reference from 0.30 x 60 to 0.35 x 70 mm. A biphasic current with 10 Hz frequency and 240 μs pulse width was used, with intensity adjusted for a visible but non-painful motor response, following the 10-10-10 protocol.~To locate the superior gluteal nerve, a longitudinal scan of the lateral iliac crest identified the nerve between the gluteus minimus and medius. The procedure used a short-axis approach at 80º to target the nerve's perineurium, with the area disinfected with chlorhexidine before needle insertion.
Study: NCT05156801

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ArchSinus stent
Description: Post FESS unilateral placement of the ArchSinus stent into the randomized ethmoid sinus cavity.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: ArchSinus stent
Description: Post FESS unilateral placement of the ArchSinus stent into the randomized ethmoid sinus cavity.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: ArchSinus stent
Description: Post FESS unilateral placement of the ArchSinus stent into the randomized ethmoid sinus cavity.
Study: NCT04708184

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GLPG3970 oral solution
Description: GLPG3970 for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GLPG3970 tablet
Description: GLPG3970 for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GLPG3970 tablet
Description: GLPG3970 for oral administration
Study: NCT06388070

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HUC3-053
Description: drops in each eye five to six times a day for 12 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Hyalein Mini Drops
Description: drops in each eye five to six times a day for 12 weeks.
Study: NCT05530967

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: TT
Description: This intervention uses questionnaire at three-time intervals (i.e., days 5, 10, and 30) and abstraction of PAP use data (days 1 - 35). Consecutive adults with moderate-severe OSA and recommended to PAP treatment will be invited to the study. Once the patient has been prescribed PAP therapy a research associate will call the patient before receiving their new PAP device. The research associate will utilize an IRB approved telephone script to discuss study details, conduct eligibility screening (inclusion/exclusion criteria), and to ask whether the patient is interested in participating.~The research associate will then send the patient an IRB approved digital information sheet. The information sheet will provide the patient an option to mark Yes if they are willing to participate in the study or No if they are not willing. Patients who indicate their willingness to participate will receive the Triage Tool in accordance with the study protocol.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: TT
Description: This intervention uses questionnaire at three-time intervals (i.e., days 5, 10, and 30) and abstraction of PAP use data (days 1 - 35). Consecutive adults with moderate-severe OSA and recommended to PAP treatment will be invited to the study. Once the patient has been prescribed PAP therapy a research associate will call the patient before receiving their new PAP device. The research associate will utilize an IRB approved telephone script to discuss study details, conduct eligibility screening (inclusion/exclusion criteria), and to ask whether the patient is interested in participating.~The research associate will then send the patient an IRB approved digital information sheet. The information sheet will provide the patient an option to mark Yes if they are willing to participate in the study or No if they are not willing. Patients who indicate their willingness to participate will receive the Triage Tool in accordance with the study protocol.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: VE
Description: A randomly selected sub-group of participants (n=30) will also receive an animated education video that provides targeted information and encouragement for self-managing your PAP problem(s). Patients in this sub-group will be asked to view a maximum of 2 different videos that are less than 2 minutes in duration. These videos are aligned with practice guideline recommendations for addressing PAP problems early in treatment. The videos will be sent digitally from Somnoware™.
Study: NCT04770090

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood samples
Description: Peripheral blood samples at the beginning of surgery, after pneumoperitoneum creation and uterine pedicles coagulation.
Study: NCT05861999

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: risdiplam
Description: Participants will receive risdiplam orally at the currently approved dose. The dose should be adapted for weight and age.
Study: NCT06343961

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intraoperative Fluorescein Angiography
Description: Targeted laser photocoagulation under the guidance of intraoperative fluoroscopy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intraoperative Fluorescein Angiography
Description: Targeted laser photocoagulation under the guidance of intraoperative fluoroscopy
Study: NCT04669080

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Health care provider cost navigation training
Description: Health care providers and asthma educators in a pediatric asthma clinic will receive an online training about the importance of cost of care conversations, how to start cost of care conversations with families, how to refer families to cost navigation resources, and how to lead asthma specialty care teams in cost navigation.
Study: NCT06256575

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Diosmin
Description: A medical food of diosmin and alka4-complex

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Corn starch one (1) capsule twice daily
Study: NCT06279585

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical therapy
Description: Health education sessions and combined therapeutic exercise sessions, based on muscular strength training and cardiorespiratory endurance.
Study: NCT06287424

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Aged Garlic Extract
Description: Subjects will be instructed to continue using their regular home oral hygiene products until the Product Distribution Visit (Visit 2). They will also be instructed not to add or change any of their regular home oral hygiene products during that time.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Aged Garlic Extract
Description: Subjects will be instructed to continue using their regular home oral hygiene products until the Product Distribution Visit (Visit 2). They will also be instructed not to add or change any of their regular home oral hygiene products during that time.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Aged Garlic Extract
Description: Subjects will be instructed to continue using their regular home oral hygiene products until the Product Distribution Visit (Visit 2). They will also be instructed not to add or change any of their regular home oral hygiene products during that time.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT05259046

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Menaquinone-7 (MK-7) tablet (333 µg)
Description: One MK-7 tablet containing 333 µg MK-7 per day

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo tablet
Description: One placebo tablet per day
Study: NCT05844527

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MRG-001
Description: MRG-001 is a novel fixed-dose drug combination administered subcutaneously to mobilize stem cells and immunomodulatory cells to the wound to accelerate healing.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: Sterile saline will serve as placebo treatment.
Study: NCT06201195

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Adductor canal blockade
Description: VAS, VAS move, incision place pain for up and down to patella, drain place pain, motor strenght for femoral nerve and siyatic nerve muscles, side effects, first analgesic requirement time, opioid requirement, other analgesics

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Distal adductor canala blockade and anterior cutaneus nerve blockade
Description: VAS, VAS move, incision place pain for up and down to patella, drain place pain, motor strenght for femoral nerve and siyatic nerve muscles, side effects, first analgesic requirement time, opioid requirement, other analgesics
Study: NCT05541692

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Sleep Hygiene Toolkit
Description: The sleep hygiene toolkit includes multiple resources including assistive devices (ie. eye masks and ear plugs), sensory-based tools (ie. aromatherapy, music, meditation, and breathing techniques), cognitive behavioral therapy (CBT) activities (ie. addressing anxiety and worry), and education and training on sleep hygiene.
Study: NCT04376346

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Native WYSE CHOICES
Description: Native WYSE (Women, Young, Strong, and Empowered) CHOICES (Changing High-risk alcohOl use and Increasing Contraception Effectiveness Study) is an alcohol-exposed pregnancy prevention program that translates CHOICES, an evidence-based targeted intervention, into an mHealth universal intervention for young urban American Indian/Alaska Native (AI/AN) women ages 16-20.
Study: NCT04197297

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: CT and MRI Scans
Description: CT and MRI scans will occur before and after radiation therapy.
Study: NCT06080113

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Focal Brachytherapy
Description: Targeted focal brachytherapy is an image-guided technique, where the radioactive source is placed only, and directly into the cancerous area of the prostate. The aim is to preserve the normal surrounding prostate gland tissue to limit treatment-related side effects to the adjacent anatomical structures. A multiparametric prostate MRI is used to identify, localize, and delineate the intraprostatic PCa tumour lesion and plan treatment. A specialized MRI-ultrasound image-fusion software combines the MRI-images with dynamic ultrasound performed in the operating room and is used to focally guide the placement of the radioactive source in the prostate cancer (PCa) tumour focus based on focal dosimetry calculations. A safety margin around the tumour is applied where it is possible to account for MRI tumour volume underestimation, microscopic spread, and treatment uncertainties.
Study: NCT05224622

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: VOX
Description: Breath exhalation into the mouthpiece of the VOX breath diagnostic device.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: VOX
Description: Breath exhalation into the mouthpiece of the VOX breath diagnostic device.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: VOX
Description: Breath exhalation into the mouthpiece of the VOX breath diagnostic device.
Study: NCT05734547

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stepping Together for Children after Trauma (ST-CT)
Description: ST-CT is Step One of Stepped Care CBT for Children after Trauma (previously called Stepped Care Trauma-focused Cognitive Behavioral Therapy; Salloum et al., 2014). It consists of five components: psychoeducation, stabilization, trauma narrative, in-vivo exposures and consolidation. The parent and child have 11 at-home-meetings and complete tasks in a workbook, Stepping Together (from the Preschool PTSD Treatment by Michael Scheeringa et al), over 6-9 weeks. In addition, there are weekly calls and five sessions with the therapist. Children who meet responder-criteria (i.e., no more than four symptoms of PTSS) continue to a 6-week maintenance phase, after which treatment is complete if the child still meets responder criteria. For those who do not meet responder-criteria, or are not able to complete the workbook, the responsibility for the treatment is transferred from the municipal service level to the corresponding child and adolescent mental health service (BUP).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Usual care
Description: Therapists in the control group will provide the treatment they usually provide, and develop a treatment plan in collaboration with the parents. This may consist of individual sessions with the child, parent sessions, group treatment, meetings with the school and other collaborating services, or referral to the second line mental health centres (BUP).
Study: NCT06575621

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Support program
Description: education, medical navigation, exercise
Study: NCT05878444

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic
Description: Resistant gastrointestinal capsules will be provided daily to the participants.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic
Description: Resistant gastrointestinal capsules will be provided daily to the participants.
Study: NCT06064682

Intervention type: OTHER
Intervention: standard of care biopsy
Description: Image-guided or surgical biopsy of the lesion that is suspected to be osteosarcoma in a patient with localized disease (Group 1)
Study: NCT04786262

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VX-880
Description: Infused into the hepatic portal vein.
Study: NCT06066710

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propranolol
Description: Propranolol will be given on a titration schedule in which participants will begin with small doses of the drug and increase to a larger dosage over the course of three weeks. Propranolol will be taken for a total of 9 weeks.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Magnetic Resonance Imaging (MRI)
Description: Magnetic Resonance Imaging (MRI) will be performed at 3 Tesla and 7 Tesla, for both propranolol and placebo arms.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging (MRI)
Description: Magnetic Resonance Imaging (MRI) will be performed at 3 Tesla and 7 Tesla, for both propranolol and placebo arms.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will be given on the same schedule as the propranolol regime.