TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04986228

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Digital aftercare
Description: The intervention group will receive a digital aftercare service, consisting of video calls and an app, for a period of up to eight weeks after discharge. These enable an uncomplicated and yet intensive exchange with the clinic from the comfort of the participants' own homes. To enable to optimally plan the treatment and assess its success, all participants complete questionnaires on multiple time points about different topics.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: TAU
Description: The control group will receive the regular follow-up consultations in the clinic (treatment-as-usual, TAU). This includes at least one consultation with the case-leading therapist from the previous inpatient stay about 6 weeks after discharge. The assessment consisting of questionnaires at multiple time points about different topics is the same as in the intervention group.
Study: NCT04901325

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib
Description: Subjects with PG will be treated with 4 mg once daily of baricitinib for 24 weeks.
Study: NCT00409019

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Telbivudine
Description: Study cancelled: Withdrawn before enrollment of any participants

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adefovir

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tenofovir
Study: NCT06249399

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aerobic Exercise
Description: Aerobic Exercise training will be provided three days a week, 45 minutes a day, for 12 weeks. Patients will be subjected to submaximal aerobic exercise with rhythmic movements without equipment via video conference accompanied by a physiotherapist.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral Treatment Program
Description: Behavioral Treatment Program will be completed with an initial training period of 40 minutes, and subsequent control interviews of 20 minutes at four-week intervals.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Behavioral Treatment Program
Description: Behavioral Treatment Program will be completed with an initial training period of 40 minutes, and subsequent control interviews of 20 minutes at four-week intervals.
Study: NCT05300984

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Topical Placebo Cream
Description: cosmetic cream to be applied topically on face and forearms twice/daily using split/face design

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Topical Placebo Cream
Description: cosmetic cream to be applied topically on face and forearms twice/daily using split/face design

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Topical Cream with 0.5% Active
Description: cosmetic cream to be applied topically on face and forearms twice/daily using split/face design

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Topical Cream with 1% Active
Description: cosmetic cream to be applied topically on face and forearms twice/daily using split/face design
Study: NCT06069297

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multimodal Prehabilitation
Description: Preoperative multimodal intervention including exercise training, nutritional therapy and anxiety reducing techniques, aimed at preventing or attenuating surgery-driven functional decline. A personalized intervention program will be prescribed based on specific physical, nutritional and psychological conditions recognized during the multimodal assessment. Patients will follow a two to three-day per week training for 4 weeks. Exercise modalities will be adapted to personal preference and patient conditions. Based on dietary habits, medical conditions and nutritional status, a certified nutritionist will provide a comprehensive diet management program. A food-based intervention with a balanced macronutrient composition coupled with oral nutritional supplements will be prescribed to achieve the estimated daily energy and protein requirements. Participants will be instructed by psychology-trained personnel on how to reduce anxiety.
Study: NCT05399264

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Auditory-working memory training program
Description: The AT-WMT program is comprised of 1,200 daily used sentences either created or selected from newspapers, books, TV programs and magazines by the research assistants. The sentences are political-, cultural-, and religious-neutral sentences. Each of them contains 10 words. Noise was recorded from the upper and lower decks of a bus, in a café, a Chinese restaurant, an MTR (the Mass Transit Railway) carriage, and from a street.~During the training, the following two adaptive tasks will be administered simultaneously: repeating the sentences masked by noise (i.e., AT component) and recalling the first or the final two words of all sentences in a given sentence set (i.e., WMT component).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Auditory training program
Description: During the training, an adaptive speech-in-noise perception task will be administered. Specifically, the sentences in a sentence set will be presented binaurally using a headphone at a level the listeners felt is comfortable. The trainees are expected to immediately repeat each noise-masked sentence after hearing it. If they cannot repeat the sentence, then the sound intensity of the noise will be automatically decreased (step size = 2 dB) until the sentence can be correctly repeated. If the sentence can be repeated at the first attempt, then the intensity of the noise will be automatically increased by 2 dB in the next sentence. To provide feedback, the targeted sentence will be replaced by an asterisk and only shown after clicking the sentence.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Mindfulness training program
Description: Participants in this group will participate in a mindfulness training program using newlife.330 (Psychiatric Rehabilitation Association, 2018) which is a Cantonese online platform for self-guided mindfulness training.
Study: NCT05852847

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib 2 MG [Olumiant]
Description: Oral baricitinib was given at a dose of 2 mg daily for 6 months. Treatment was discontinued if very severe or life-threatening adverse events developed or at the patients' request.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Danazol
Description: Danazol was given at a dose of 200 mg bid for 6 months

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Danazol
Description: Danazol was given at a dose of 200 mg bid for 6 months
Study: NCT05129098

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Left bundle branch pacing lead (Select Secure 3830 lead)
Description: Implantation of a left bundle branch pacing lead via sheath

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Right ventricular active fixation lead
Description: Active fixation lead (standard)
Study: NCT04750187

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hypo-pressive abdominal exercise intervention
Description: An 8-week hypo-pressive abdominal exercise program
Study: NCT04107870

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Virtual Reality Exposure Therapy sessions
Description: Female adolescents aged 13 to 18 are proposed virtual reality exposure therapy sessions, accompanied by a cognitive and behavioral therapy (CBT) therapist, to work on their body representations

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Psychomotor therapy sessions
Description: Psychomotor therapy sessions are proposed to female adolescents aged 13 to 18 years, ac-companied by a psychomotor therapist, to work on their body representations.
Study: NCT05602519

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: propofol, rocuronium and fentanyl
Description: In fentanyl group (36 patients), 50 ug of fentanyl, and in oxycodone group, 4 mg of oxycodone will be administered 20 minutes before the end of the surgery, in triple blind manner.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: propofol, rocuronium and fentanyl
Description: In fentanyl group (36 patients), 50 ug of fentanyl, and in oxycodone group, 4 mg of oxycodone will be administered 20 minutes before the end of the surgery, in triple blind manner.
Study: NCT05140447

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: preheating of resin composite
Description: evaluate the effect of preheating BIS-GMA free resin composite at different temperatures on temperature change of the pulpal floor and restorations and compare it with BIS-GMA containing resin composite.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: preheating of resin composite
Description: evaluate the effect of preheating BIS-GMA free resin composite at different temperatures on temperature change of the pulpal floor and restorations and compare it with BIS-GMA containing resin composite.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: preheating of resin composite
Description: evaluate the effect of preheating BIS-GMA free resin composite at different temperatures on temperature change of the pulpal floor and restorations and compare it with BIS-GMA containing resin composite.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: preheating of resin composite
Description: evaluate the effect of preheating BIS-GMA free resin composite at different temperatures on temperature change of the pulpal floor and restorations and compare it with BIS-GMA containing resin composite.
Study: NCT05382221

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Comprehensive Chronic Care
Description: Those randomized to CCC will receive smoking treatment offers via the following routes: 1) Four Outreach Calls from a Health Counselor at 4, 8, 12, and 14 months post-study enrollment; 2) Four texts and/or mailings (depending on healthcare system preferences) over 14 months. These outreach contacts will offer cessation treatment or reduction treatment.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard Care
Description: one offer of cessation treatment annually
Study: NCT06167538

Intervention type: OTHER
Intervention: Decannulation
Description: From the 1st of September 2021, the investigators started to perform decannulation earlier after admission to the Department of Brain Injury. Before attempting to decannulate a patient, several factors were considered and assessed by the patient's treating team: patient's level of consciousness, hemodynamical stability, need for and frequency of salivary aspiration, cough strength and respiration frequency. Patients could not be under treatment for pneumonia and simultaneously have respiratory instability at the time of decannulation.

Intervention type: OTHER
Intervention: Decannulation
Description: From the 1st of September 2021, the investigators started to perform decannulation earlier after admission to the Department of Brain Injury. Before attempting to decannulate a patient, several factors were considered and assessed by the patient's treating team: patient's level of consciousness, hemodynamical stability, need for and frequency of salivary aspiration, cough strength and respiration frequency. Patients could not be under treatment for pneumonia and simultaneously have respiratory instability at the time of decannulation.
Study: NCT06200701

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Job Crafting program
Description: The training program designed for this study was implemented through twelve sessions, from which three theory and nine practical sessions were held in a room at the worksite. The sessions were conducted outside of working hours in the hospital These sessions lasted 21 hours; 3 theory hours (one hour for each theoretical session); and 9 practical sessions (two hours for each practical session). Having the whole number of nurses at the same time was difficult, so the nurses were classified into five groups each group consisting of about 16 nurses. All sessions were repeated to the five main groups until 80 nurses completed the entire 21-hours instruction period
Study: NCT06284525

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ankle resistance and biofeedback
Description: An ankle exoskeleton will provide stance phase resistance and a plantar pressure biofeedback system will encourage late stance push-off.
Study: NCT05914103

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: ERAS
Description: The primary endpoint is the rate of composite outcomes. The composite outcomes include the major adverse cardiac events (MACE), major postoperative pulmonary complication (PPCs), and acute kidney injury (AKI)
Study: NCT05423808

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Health Professional Consortium
Description: In the intervention group, the renewed, patient-centred care pathway will be coordinated by the Advanced Practice Nurse (APN) and will be supported by digital technology. The intervention aims to increase the involvement of the patient in the treatment decision process, to provide comprehensive care through the quarterly meeting of all professionals involved in the care of the patient during a Health Professional Consortium (HPC) and to support patient empowerment by supporting self-management by using digital tools.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Holis Dashboard - Holis Patient App
Description: In the intervention group, the renewed, patient-centred care pathway will be coordinated by the Advanced Practice Nurse (APN) and will be supported by digital technology. The intervention aims to increase the involvement of the patient in the treatment decision process, to provide comprehensive care through the quarterly meeting of all professionals involved in the care of the patient during a Health Professional Consortium (HPC) and to support patient empowerment by supporting self-management by using digital tools.
Study: NCT05904808

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV Furosemide
Description: Given over 4-hour drip using IV pump, 40mg of the 250mg will be given as a bolus

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV Furosemide and PO Metolazone
Description: Given over 4-hour drip using IV pump, 40mg of the 250mg will be given as a bolus +5mg PO Metolazone

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV Furosemide and IV Acetazolamide
Description: Furosemide would be given over 4-hour drip using IV pump, 40mg of the 250mg will be given as a bolus.~500mg IV Acetazolamide would be given in 100cc of saline over half an hour
Study: NCT06241378

Intervention type: DEVICE
Intervention: perineometer device for physiotherapy
Description: measuring the vaginal pressure for stress urinary incontinence patients
Study: NCT05266248

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 250 mg encapsulated caffeine
Description: Zero calorie 500 ml (16.9 oz) flavored, carbonated energy beverage

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 250 mg encapsulated caffeine
Description: Zero calorie 500 ml (16.9 oz) flavored, carbonated energy beverage
Study: NCT05344872

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Weaning from mechanical ventilation
Description: Weaning from mechanical ventilation post congenital cardiac surgery

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Weaning from mechanical ventilation
Description: Weaning from mechanical ventilation post congenital cardiac surgery
Study: NCT05019066

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Herbal Supplementation
Description: A proprietary blend of: Eclipta alba, Emblica officinalis, Centella asiatica and Hibiscus sabdariffa.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Herbal Supplementation
Description: A proprietary blend of: Eclipta alba, Emblica officinalis, Centella asiatica and Hibiscus sabdariffa.
Study: NCT06220292

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Care
Description: Basic treatment, including corresponding control of risk factors and education on healthy lifestyles.~Swallowing training, including lemon ice stimulation, mendelson maneuver, empty swallowing training, and pronunciation training.~Pulmonary function training, including standing training, cough training, and diaphragm muscle training.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Conventional Care
Description: Basic treatment, including corresponding control of risk factors and education on healthy lifestyles.~Swallowing training, including lemon ice stimulation, mendelson maneuver, empty swallowing training, and pronunciation training.~Pulmonary function training, including standing training, cough training, and diaphragm muscle training.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Intermittent Oral-esophageal Tube Feeding
Description: The observation group was given enteral nutritional support with Intermittent Oro-esophageal Tube according to the following procedure: Before each feeding, inside and outside of the tube was cleaned with water. During feeding, the patient should maintain a semi-reclining or sitting position with mouth opened, and the tube was inserted slowly and smoothly into the upper part of the esophagus by medical staffs while the appropriate depth of intubation was checked with the calibration markings on the tube wall. The distance from the incisors to the head part of the tube should be between 22-25 cm. However, the specific depth should be evaluated based on patients' feedback and adjusted accordingly. After insertion, the tail part of the tube should be put into a container full of water and the absence of continuous bubbles indicated a successful intubation. Then, the feeding was to be conducted three times per day with 50 ml per minute and 400-600ml for each feeding.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Nasogastric tube
Description: Besides, the control group was given enteral nutritional support with Nasogastric tube according to the relevant guidelines. Within 4 hours after admission, the placement of the feeding tube was conducted by professional medical staffs and after intubation, the tube was secured to the patient's cheek with medical tape. The feeding was conducted once every 3-4 hours, with 200-300ml each time. The total feeding volume was determined based on daily requirements. The feeding content was formulated by the nutritionists based on the patient's condition and relevant guidelines to reach the energy demand as 20-25 kcal/kg/day and protein supplementation of 1.2-2.0 g/kg/day for both two groups. For patients with limited tube feeding compliance, we made appropriate adjustments to ensure that they were not at risk of severe malnutrition as much as possible.
Study: NCT06441435

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Low protein diet with AC-134
Description: Low protein diet combined with AC-134 Dosage: 2 capsules,three times/day

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard treatment
Description: Low protein diet
Study: NCT04774432

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: GM-CSF group
Description: GM-CSF added to CAPA and maturation medium

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control group
Description: GM-CSF will not be added to CAPA and maturation medium
Study: NCT06299137

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Serratus Anterior Plane Block
Description: Patients who undergo randomization to the intervention arm will undergo the Serratus Anterior Plane Block.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ropivacaine injection
Description: For the Serratus Anterior Plane Block, Ropivacaine will be used as the anesthetic.
Study: NCT06543966

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aprepitant Injection
Description: Before anesthesia induction, 4.4ml(32mg） was given by a single intravenous injection, which was completed within 30 seconds

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Aprepitant Injection Placebo
Description: Before anesthesia induction, 4.4ml(0mg） was given by a single intravenous injection, which was completed within 30 seconds
Study: NCT05177627

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Theoretical and classroom learning interventions
Description: aim of intervention: introduce students to the conceptual framework of fundamental of care, focus on three dimensions necessary for the delivery of high-quality fundamental care (the nurse-patient relationship; addressing different fundamental needs; and a context that supports these goals)~components and activities:~* educational interventions to understand how the communication and the relationship of trust between nurse and patient are the prerequisites for high quality nursing care;~* drawing attention to five essential relational elements for establishing the nurse-patient relationship (Trust; Focus; Anticipate; Know; Evaluate)~mode of delivery:~* classroom lessons on philosophies and theories on communication and trust~* small-group learning on realistic cases focused on fundamental needs to develop reflexivity, analytical skills, investigation~duration of the intervention: 12 hours of theoretical and classroom learning

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Simulation interventions
Description: aim of intervention:~To develop active listening and use of non-verbal and verbal communication skills to establish a therapeutic relationship based on compassion, trust and respect; to apply the FoC conceptual framework, reflexivity and analytical skills to meet patient fundamental needs.~Students will express these goals during simulation activities with behaviours outlined by the FoC framework.~components and activities: - Implementation of communication simulation activities to develop interaction skills with patients; Implementation of simulation activities to apply the FoC conceptual framework and reflection to meet patient fundamental needs in realistic scenarios.~mode of delivery:~- simulation activities on communication and trust Use ad hoc validated scenarios to apply the FoC conceptual framework to develop reflection and meet patient fundamental needs.~duration of the intervention: 25 hours

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Internship interventions
Description: Aim of intervention: to apply active listening and non-verbal communication skills; to use the FoC conceptual framework, reflexivity, and analytical skills to meet patient fundamental needs.~Students will express these goals during simulation activities with behaviours outlined by the FoC framework.~components and activities:~- to establish effective and trusting communication with patients to demonstrate compassion and respect and to enable patients to remain calm, involved and dignified; to apply the FoC conceptual framework to meet patient fundamental needs.~mode of delivery:~* attendance of clinical internship~* analysis and reflections guided by the clinical preceptor on real cases using elements of FoC conceptual framework.~duration of the intervention: 150 hours of internship.