TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05128136

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Impact of ring size on adherence
Description: The study design is a randomized, open-label, parallel group 3-way crossover study comparing adherence, preference and overall acceptability of 3 different-sized placebo IVRs (IVRs A, B and C) in 24 US couples. At enrollment, each couple will be randomly assigned to 1 of 6 sequences of IVR use: A-B-C, A-C-B, B-A-C, B-C-A, C-A-B or C-B-A. Each couple will use each of the 3 IVRs (IVRs A, B and C) for 30 days per IVR, 90 days total.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Impact of ring size on adherence
Description: The study design is a randomized, open-label, parallel group 3-way crossover study comparing adherence, preference and overall acceptability of 3 different-sized placebo IVRs (IVRs A, B and C) in 24 US couples. At enrollment, each couple will be randomly assigned to 1 of 6 sequences of IVR use: A-B-C, A-C-B, B-A-C, B-C-A, C-A-B or C-B-A. Each couple will use each of the 3 IVRs (IVRs A, B and C) for 30 days per IVR, 90 days total.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Impact of ring size on adherence
Description: The study design is a randomized, open-label, parallel group 3-way crossover study comparing adherence, preference and overall acceptability of 3 different-sized placebo IVRs (IVRs A, B and C) in 24 US couples. At enrollment, each couple will be randomly assigned to 1 of 6 sequences of IVR use: A-B-C, A-C-B, B-A-C, B-C-A, C-A-B or C-B-A. Each couple will use each of the 3 IVRs (IVRs A, B and C) for 30 days per IVR, 90 days total.
Study: NCT04840927

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: E7386
Description: Regimen A: 40 milligram (mg) IR Oral Tablet.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: E7386
Description: Regimen A: 40 milligram (mg) IR Oral Tablet.
Study: NCT05485051

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 2% chlorhexidine digluconate solution with surface-active agents
Description: Bathing will be performed at least daily using 2% chlorhexidine digluconate solution with surface-active agents on all applicable bathing surfaces, which consists of the entire body surface of the patient except eyes, inner ear, oral mucosa, and areas of loss of skin continuity (such as burnt areas, pressure injuries, etc.); These areas will be bathed according to each center current practice.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual Baths
Description: Bathing will be performed at least daily using soap and water (performed according to the current practice in each center) on all applicable bathing surfaces, which consists of the entire body surface of the patient except eyes, inner ear, oral mucosa, and areas of loss of skin continuity (such as burnt areas, pressure injuries, etc.); These areas will be bathed according to each center current practice.
Study: NCT06460012

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Unrestricted Access
Description: Following the STELLA-R curriculum, care partners will receive 8 weeks of unrestricted access to all lessons and resources.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Limited Access
Description: Experimental and Waitlist Control group will experience 8 consecutive weeks of limited access to the STELLA-R website and resources. Waitlist Control will experience this from Week 1 to Week 8 while the Experimental Group will reach this phase from Week 17 to Week 24.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Limited Access
Description: Experimental and Waitlist Control group will experience 8 consecutive weeks of limited access to the STELLA-R website and resources. Waitlist Control will experience this from Week 1 to Week 8 while the Experimental Group will reach this phase from Week 17 to Week 24.
Study: NCT04798105

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Effects of tDCS of dlPFC on Probabilistic Selection Task
Description: Predictors of Probabilistic Selection Task Performance including anodal tDCS of dlPFC, eye blink rate, extraversion and impulsiveness

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Effects of tDCS of dlPFC on Probabilistic Selection Task
Description: Predictors of Probabilistic Selection Task Performance including anodal tDCS of dlPFC, eye blink rate, extraversion and impulsiveness
Study: NCT06284109

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cryoanalgesia
Description: Participants will receive cryoanalgesia with the The iovera° system. . The specific nerves targeted will be both the sciatic, targeted first (as distal as possible, but not more distal than the bifurcation), and femoral, targeted second (as distal as possible, but not more distal than the adductor canal). Cryoanalgesia will result from an 8-minute-long percutaneous cryoneuroablation procedure consisting of several freeze/defrost cycles. Per routine, all patients will have a nerve block with single shot ropivacaine.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Cryoanalgesia
Description: Participants will receive Sham cryoanalgesia with the The iovera° system. The specific nerves targeted will be both the sciatic, targeted first (as distal as possible, but not more distal than the bifurcation), and femoral, targeted second (as distal as possible, but not more distal than the adductor canal). Per routine, all patients will have a nerve block with single shot ropivacaine.
Study: NCT05414565

Intervention type: DEVICE
Intervention: Vivity IOL
Description: Commercially available extended vision IOL

Intervention type: DEVICE
Intervention: Aspheric monofocal IOL
Description: Commercially available aspheric IOL
Study: NCT05713305

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Online-based self-help psychological intervention
Description: Daily members of the intervention group were thought to provide three different forms of daily sessions each day, averaging 10-20 minutes. These sessions included psycho-educational and cognitive-behavioral exercises, music therapy, sleep hygiene, stress relief methods. Weekly online lecture sessions presented by professional mental health therapists

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Provide online mental health knowledge
Description: They will receive official mental health recommendations on how to cope mentally with the pandemic. These recommendations inform about the importance of a daily structure, social contact, acceptance of negative emotions and strengthening of positive emotions, and stimulus control to assimilate SARS-CoV-2 Omicron-related news
Study: NCT05228912

Intervention type: DRUG
Intervention: COVID-19 Vaccines
Description: Each group will receive a complete scheme of the vaccine according to local government assignation

Intervention type: DRUG
Intervention: COVID-19 Vaccines
Description: Each group will receive a complete scheme of the vaccine according to local government assignation

Intervention type: DRUG
Intervention: COVID-19 Vaccines
Description: Each group will receive a complete scheme of the vaccine according to local government assignation

Intervention type: DRUG
Intervention: COVID-19 Vaccines
Description: Each group will receive a complete scheme of the vaccine according to local government assignation

Intervention type: DRUG
Intervention: COVID-19 Vaccines
Description: Each group will receive a complete scheme of the vaccine according to local government assignation

Intervention type: DRUG
Intervention: COVID-19 Vaccines
Description: Each group will receive a complete scheme of the vaccine according to local government assignation

Intervention type: DRUG
Intervention: COVID-19 Vaccines
Description: Each group will receive a complete scheme of the vaccine according to local government assignation
Study: NCT05646069

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Storz Flex-XC1 Disposable Flexible Ureteroscope
Description: Patients will receive flexible ureteroscopy with the Storz Flex-XC1 disposable flexible ureteroscope.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Storz Flexible Digital Ureteroscope
Description: Patients will receive flexible ureteroscopy with the Storz flexible Digital ureteroscope.
Study: NCT05438485

Intervention type: OTHER
Intervention: Registry
Description: Observational (Registry)

Intervention type: OTHER
Intervention: Registry
Description: Observational (Registry)
Study: NCT06671847

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: THERABand resistance exercise bands
Description: The training will be performed using THERABand resistance exercise bands.Participants will be instructed to perform the exercises twice per week at home, for the 24 weeks duration. Each exercise session will entail 1 set of 15 repetitions of 9 different exercises
Study: NCT06671834

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07905428
Description: Topical solution of PF-07905428 0.08% or PF-07905428 0.24%

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07905428
Description: Topical solution of PF-07905428 0.08% or PF-07905428 0.24%

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Topical solution of placebo
Study: NCT05847270

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Anterior and posterior treatment strategy
Description: Before surgery, a large weight traction of 1/6 body weight was used to determine the reversibility of atlantoaxial dislocation. After determining that it is difficult to restore the dislocation, a technique of anterior oral release and posterior fixation fusion was used for reduction, with sequential release of the longus colli and longus capitis, the anterior longitudinal ligament, the blitateral lateral mass joints, the contracted soft-tissue mass between the odotiod and the anterior C1 tubercle, and the peri-odontoid ligaments (i.e., the alar ligaments and the apical ligament), followed by posterior internal fixation and bone grafting was used between C1 and C2 lamina.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Simple posterior approach treatment strategy
Description: Preceding the surgical procedure, an assessment was conducted utilizing 1/6 weight traction to ascertain the reducibility of atlantoaxial dislocation. Upon confirmation of IAAD, the chosen approach involved the utilization of a specially designed spreader, tailored to the patient's atlanto-axial joint morphology. Upon entering the joint space, the spreaders were skillfully maneuvered to gently open the joint through rotational and prying actions. Subsequently, two cages, pre-filled with autogenous bone grafts, and designed with the appropriate angle and height, were meticulously placed between the Atlanto-axial joints via a posterior approach. This procedure facilitated direct distraction and reduction of the dislocated joint. In the final step of the surgical process, stabilization was achieved by securing the atlas and axis with screws and rods. This surgical approach was selected to address the unique challenges posed by IAAD, with the aim of achieving optimal patient outcomes.
Study: NCT06671275

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Cell therapy
Description: Subjects were placed sequentially into three different dose groups, 5.0×107 cells/time (low-dose group), 1.5×108 cells/time (medium-dose group), and 5.0×108 cells/time (high-dose group) for dose escalation
Study: NCT06671249

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Laparoscopic breast-conserving surgery
Description: Use laparoscopic surgery to treat breast cancer patients who want and have the opportunity to preserve their breast

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Traditional open breast-conserving surgery
Description: Treat breast cancer patients who want and have the opportunity to preserve their breast with traditional open breast-conserving surgery.
Study: NCT06671171

Intervention type: DEVICE
Intervention: Apple Watch Series 9
Description: Participants will wear Apple Watch Series 9 during cardiopulmonary exercise test (in Visit 1), 1-week study period and 6-Minute walk distance test (in Visit 2) to have assessment of maximal oxygen uptake and pre- and post-SaO2.~During 1-week study period, participants will measure their oxygen saturation once daily with a medical-grade pulse oximeter while wearing the smartwatch continuously.
Study: NCT06681740

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Inspiratory muscle training
Description: The control group will perform a standard cardiac rehabilitation program, consisting of 16 multicomponent exercise sessions, health education, and a weekly group of psychological therapy session. The intervention group will do the same program with the addition of Inspiratory Muscle Training (IMT). The following device will be used: Power Breath model: Medic Classic. The training will be performed by adjusting the device load to 70% of the Maximum Inspiratory Pressure value, performing 1 daily training session 4 days a week of 3 sets of 10 repetitions, with a rest of 3 minutes between sets, during 8 weeks. A physical therapist will teach participants how to use the device on the first day and they will be instructed to perform it at home. They will be given a diary to record their compliance. In addition, once a week the physiotherapist will supervise the execution of the IMT by the participants.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Inspiratory muscle training
Description: The control group will be given the same device as experimental group, but the load for all of the participants of the control group will be 5cm de H2O. This load is so low that it´s not able to induce improvement of the inspiratory musculature.
Study: NCT06688032

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Jarlsberg cheese
Description: Jarlsberg cheese contains Propionebacterium freudenreichii (PF) producing the K2-vitamer MK-9(4H) and DHNA in addition to the K2-vitamers found in Norvegia cheese

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Norvegia
Description: Cheese with different content of K2 vitamers
Study: NCT06689735

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: schroth exercises
Description: Exercises will be given in lying, sitting and standing positions. In each exercise, elongation of the spine will be ensured and the person will be positioned according to the type of scoliosis. Exercises will be given progressively in supine, prone, side sitting, sitting and standing positions. In each exercise, elongation of the spine will be ensured and the person will be positioned according to the upper and lower extremities. Progress in the exercises will be made positionally by increasing the number of repetitions and the number of rotational breathing during the exercise.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pilates exercises
Description: The average application time of the exercises is 30-40 minutes (with the first 10 minutes of warming up and the last 5 minutes of stretching). The first four exercises were used for the warm-up period and the last four exercises were used for the stretching period. The exercises will be done as 1 set of 8 repetitions. The Hundred exercise will be increased to 10 sets of 10 reps every two weeks to 10 reps, 12 reps, and 14 reps, respectively.
Study: NCT06099873

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ZX-7101A
Description: Day1 Take one tablet of ZX-7101A orally once (specification: 40mg/ tablet) with appropriate amount of warm water

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Day1 Take one tablet of Placebo orally once with appropriate amount of warm water
Study: NCT06693427

Intervention type: PROCEDURE
Intervention: Peripheral Nerve Block
Description: Femoral and Sciatic Nerve Blocks
Study: NCT06692777

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Bergavit
Description: Subjects treated with Bergavit capsule intake of 150 mg/die of pure flavonoids for 4 months.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subjects will take capsule equivalent amount of maltodextrin for 4 months.
Study: NCT06693193

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Immersive Virtual Reality
Description: Individuals will participate in three VR sessions using Oculus headsets, experiencing virtual environments featuring realistic natural stimuli or custom settings tailored to their preferences and valued activities. Each environment allows for the adjustment of auditory elements (such as animal sounds, rustling wind, or specific music), visual elements (such as people, objects, or animals), and the time of day and weather conditions. The operator will use a user-friendly smartphone app to customize the environment, making real-time adjustments to settings and content. Throughout the VR experience, the operator can monitor the participant's visual focus in real-time.
Study: NCT06692010

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine with Dexamethasone Solution
Description: 10 to 15 ml %0.25 bupivacaine \& 4 mg Dexamethazone

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine with Dexamethasone Solution
Description: 10 to 15 ml %0.25 bupivacaine \& 4 mg Dexamethazone
Study: NCT06693401

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention group: PD rehabilitation complemented with Occupational Therapy programme
Description: In intervention group both Physiotherapy and Occupational Therapy programmes were implemented.~Occupational Therapy programme consisted in trainning the amplitude of the movements involved in the realization of each letter of the alphabet separately and through fine motor exercises. Specifically the tasks consisted of performing:~1. 2 types of handwriting exercises, namely for tracing the upper and lower-case letters of the alphabet guided by dotted lines and writing a sentence with and without spatial boundaries, in Portuguese language (to be performed for about 45 minutes, three times a week) and;~2. 4 groups of fine motor tasks exercises, namely for hand manipulation (2 exercises), finger isolation (3 exercises), finger flexion and extension (2 exercises) and coordination (1 exercise). All exercises were performed 10 times, in triplicate, for each hand on a regular basis of 2-3 times per week.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control Group: conventional physiotherapy programme
Description: In this group only the conventional physiotherapy programme was implemented. This programme has the purpose of improving balance and reducing the risk of falls, enhancing mobility and motor function, managing muscle stiffness and rigidity, addressing gait abnormalities, and providing education and support. In this regard, participants were guided and supervised in each physiotherapy session by a Parkinson's disease healthcare specialist.
Study: NCT06047717

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Reality Driving Task
Description: Participants will steer a virtual car with the goal of staying in the center of a single-lane roadway while traveling at a constant speed of 26.6 m/s (approximately 60 miles/hr). The roadway alternates between a series of straights and turns of different radii to both the left and the right. This allows for careful control of task difficulty, and for the repeated presentation of specific conditions across multiple trials (i.e. turns in the road) in a randomized order. In addition, the density of the visual texture elements in the virtual environment that provide optic flow (OF) signal is also varied. The low-density OF condition has no road texture or foliage, and only the solid road edges on a flat-black ground plane. The medium-density OF condition has sparse textural elements distributed on the ground plane, and the high-density OF condition has high density road texture and a canopy of road-side trees that provide texture extending far above the horizon.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Reality Driving Task
Description: Participants will steer a virtual car with the goal of staying in the center of a single-lane roadway while traveling at a constant speed of 26.6 m/s (approximately 60 miles/hr). The roadway alternates between a series of straights and turns of different radii to both the left and the right. This allows for careful control of task difficulty, and for the repeated presentation of specific conditions across multiple trials (i.e. turns in the road) in a randomized order. In addition, the density of the visual texture elements in the virtual environment that provide optic flow (OF) signal is also varied. The low-density OF condition has no road texture or foliage, and only the solid road edges on a flat-black ground plane. The medium-density OF condition has sparse textural elements distributed on the ground plane, and the high-density OF condition has high density road texture and a canopy of road-side trees that provide texture extending far above the horizon.
Study: NCT04770779

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Matching Mitapivat
Description: Tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitapivat
Description: Tablets

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Mitapivat
Description: Tablets
Study: NCT06054815

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DA-1241
Description: Route of Administration: Oral, with subjects in a fasting state

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DA-1241
Description: Route of Administration: Oral, with subjects in a fasting state
Study: NCT06066918

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pregabalin 75mg
Description: Pregabalin 75 mg twice a day
Study: NCT05458284

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Real Acupuncture
Description: Real Acupuncture weekly till taxane completion

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Sham Acupuncture
Description: Sham Acupuncture weekly till taxane completion
Study: NCT05910801

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: Undergo biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Aspiration
Description: Undergo bone marrow aspiration

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Biopsy
Description: Undergo bone marrow biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT scan

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide
Description: Given PO

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lumbar Puncture
Description: Undergo lumbar puncture

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo PET/CT scan

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Tafasitamab
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Given PO