TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06300853

Intervention type: OTHER
Group type: OTHER
Intervention: Analisys of cellular response and humoral response to SARS-CoV-2 vaccine booster doses
Description: Whole blood and serum samples will be longitudinally collected at the moment of the administration of the booster doses (T0) and three weeks after the booster doses (T1). Possible further time points will be collected within 2 years, based on the National recommended future vaccination regimens.~Biological samples will be used for the following exams:~* Cellular immunity characterization~  * T- and B-cells Immunophenotype.~ * Specific T-cell response.~ * In vitro specific B-cells characterization.~ * Antibody-dependent cellular cytotoxicity.~* Humoral response characterization~  * Serology assays.~ * Avidity assay.~ * Neutralization assays with different SARS-CoV-2 variants.~ * Presence of specific or cross-reactive antibodies for common hCoV.~* Genetic and epigenetic analysis

Intervention type: OTHER
Group type: OTHER
Intervention: Analisys of cellular response and humoral response to SARS-CoV-2 vaccine booster doses
Description: Whole blood and serum samples will be longitudinally collected at the moment of the administration of the booster doses (T0) and three weeks after the booster doses (T1). Possible further time points will be collected within 2 years, based on the National recommended future vaccination regimens.~Biological samples will be used for the following exams:~* Cellular immunity characterization~  * T- and B-cells Immunophenotype.~ * Specific T-cell response.~ * In vitro specific B-cells characterization.~ * Antibody-dependent cellular cytotoxicity.~* Humoral response characterization~  * Serology assays.~ * Avidity assay.~ * Neutralization assays with different SARS-CoV-2 variants.~ * Presence of specific or cross-reactive antibodies for common hCoV.~* Genetic and epigenetic analysis
Study: NCT05824429

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Urotherapy
Description: Urotherapy is an umbrella term that includes components such as information about bladder function and problem, lifestyle changes including the regulation of voiding and fluid intake times, correct toilet positions, information about bladder irritants, and motivation. All participants included in our study will be given urotherapy training before starting PFM exercises and CTM with their families.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Urotherapy
Description: Urotherapy is an umbrella term that includes components such as information about bladder function and problem, lifestyle changes including the regulation of voiding and fluid intake times, correct toilet positions, information about bladder irritants, and motivation. All participants included in our study will be given urotherapy training before starting PFM exercises and CTM with their families.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Diaphragmatic Breathing Exercises
Description: In our research, diaphragm breathing exercises will be applied to both groups before starting PFM exercises in sessions for 8 weeks, 3 days a week.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Diaphragmatic Breathing Exercises
Description: In our research, diaphragm breathing exercises will be applied to both groups before starting PFM exercises in sessions for 8 weeks, 3 days a week.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PFM Exercises
Description: PFM exercises will be started after children learn to contract and relax their PFM in isolation without the use of auxiliary muscles. In the exercises, fast and slow contractions targeting type 1 and type 2 muscle fibers will be taught to increase both strength and endurance of PFM.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PFM Exercises
Description: PFM exercises will be started after children learn to contract and relax their PFM in isolation without the use of auxiliary muscles. In the exercises, fast and slow contractions targeting type 1 and type 2 muscle fibers will be taught to increase both strength and endurance of PFM.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Connective Tissue Manipulation
Description: CTM is a reflex treatment technique that is applied manually by physiotherapists to the skin area and acts on some cells and connective tissue by making short and long pulls (. In our study, CTM will be applied to our study group, where CTM and PFMR will be applied together, 3 days a week, for a total of 8 weeks.~The application will be made to the basic region (sacral), lower thoracic, abdominal and anterior pelvic region.
Study: NCT06485154

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TLD - Tenofovir Disoproxil Fumarate / Lamivudine / Dolutegravir
Description: Dolutegravir, lamivudine and tenofovir disoproxil fumarate tablets, a combination of dolutegravir (integrase strand transfer inhibitor \[INSTI\]), lamivudine, and tenofovir disoproxil fumarate (both nucleoside reverse transcriptase inhibitors), is indicated as a complete regimen for the treatment of HIV-1 infection in adults and pediatric patients weighing at least 35 kg
Study: NCT06549387

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Corneal cross linking
Description: Applying UVA irradiation to the cornea after soaking with riboflavin

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Corneal cross linking
Description: Applying UVA irradiation to the cornea after soaking with riboflavin

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Corneal cross linking
Description: Applying UVA irradiation to the cornea after soaking with riboflavin
Study: NCT06205186

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Army Health
Description: A whole health mobile application for Soldiers
Study: NCT06345001

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAY3630942
Description: IV, Single administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAY3630942
Description: IV, Single administration
Study: NCT06327061

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Network overdose prevention
Description: Participants are taught overdose prevention methods with network members.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard of care health education
Description: Participants will receive the standard of care for overdose prevention.
Study: NCT06345001

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAY3547922
Description: IV, Single infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAY3547922
Description: IV, Single infusion
Study: NCT05600894

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo collection of blood and buccal samples

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Biospecimen Collection
Description: Undergo collection of blood and buccal samples

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Aspiration
Description: Undergo bone marrow aspiration

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Bone Marrow Aspiration
Description: Undergo bone marrow aspiration

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Biopsy
Description: Undergo bone marrow biopsy

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Bone Marrow Biopsy
Description: Undergo bone marrow biopsy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Decitabine and Cedazuridine
Description: Given PO

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Decitabine and Cedazuridine
Description: Given PO

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Given PO
Study: NCT05884450

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupressure
Description: Acupressure is an integrated method of applying physical pressure to acupuncture points on the body surface with hands, elbows or various tools. With good counseling, patients can apply this method, which is non-invasive, easy to apply and safe, on their own.
Study: NCT06436417

Intervention type: DEVICE
Intervention: Analgesia Nociception Index (ANI) Monitor
Description: Non-invasive monitoring of HRV to evaluate autonomic nervous system activity using the indices of Energy (SDNN) and ANI (HFnu).

Intervention type: DEVICE
Intervention: Analgesia Nociception Index (ANI) Monitor
Description: Non-invasive monitoring of HRV to evaluate autonomic nervous system activity using the indices of Energy (SDNN) and ANI (HFnu).

Intervention type: BEHAVIORAL
Intervention: Trimodal Prehabilitation
Description: Program of physical exercise, nutritional supplementation, and psychological support according to the RICA guidelines of the Spanish Group for Multimodal Rehabilitation.
Study: NCT06232343

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Parachute Resistance Training
Description: The training programmed duration is of four weeks.The groups will follow the training programmed three times a week. The daily schedule (training group) included four repetitions of maximum intensity 30 m \& 50 m dashes (4 × 30 m, 4 × 50 m). The duration of recovery time between the 30 m \& 50 m runs will be 4 and 6 minutes respectively. Between the last 30 m dash and the first 50 m dash, a 10-minute recovery will be applied. Moreover, sprint speed training should not exceed 400-500 meters in total . To this end, the training programmed of the present study consisted of 4x30m and 4x50m runs, at a frequency of 3 times a week.

Intervention type: OTHER
Group type: OTHER
Intervention: Sprinters
Description: control group perform sprinters without any external resistance training for four weeks.
Study: NCT06163859

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intervention Group
Description: FCHVs will undergo a 4-day training program on hypertension management, including screening, counseling, medication adherence, self-care, and referrals. They will then collaborate with healthcare facilities to conduct one-day hypertension screening camps. FCHVs will form self-support groups for individuals with hypertension and hold monthly meetings to discuss control strategies, review BP logs, and promote healthcare visits, including family involvement. They will also maintain regular communication with healthcare facility in-charges to ensure effective collaboration in the 'Hypertension Care Cascade Model'.
Study: NCT06125418

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: customized healing abutment
Description: patients will undergoes one-stage implant placement with customized healing abutments with different macrogeometry and emergence angle made prior to the surgery and will be inserted without sutures, after osseointegration completed patients will received single crown on implant.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: standard healing abutment
Description: patients will undergoes one-stage implant placement with standard titanium healing abutment made prior to the surgery and will be inserted without sutures, after osseointegration completed patients will received single crown on implant.
Study: NCT05946733

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Group A
Description: After induction of general anesthesia, oblique subcostal TAP blocks will be done(14) under the guidance of Sonosite ,superficial probe ,14-15 MHz ultrasound transducer

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Group B
Description: After induction of general anesthesia, bilateral lateral TAP block will be performed (15) under ultrasonographic guidance with transportable ultrasound device ( Sonosite ,superficial probe ,14-15 MHz)

Intervention type: OTHER
Group type: OTHER
Intervention: Group C
Description: the analgesia will be maintained using a morphine patient-controlled analgesia (PCA) device set to give 1.5 mg bolus administration of morphine without a basic rate and 15 min lock-out time. The total amount of morphine administration will be recorded for the subsequent 24 h
Study: NCT06485505

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ISOtretinoin 10 MG
Description: Low dose isotretinoin as an adjuvant for itraconazole in treating onychomycosis

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: excimer light
Description: excimer light as an adjuvant for itraconazole in treating onychomycosis

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Itraconazole 200 mg
Description: Itraconazole alone
Study: NCT06134440

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Impact Oral®
Description: All patients will follow low-fiber diet according to ERAS protocol during the study period. Patients assigned to the experimental arm will assume also Impact Oral®, an oral nutritional supplement with immune-nutrients (hyper-proteic formula), manufactured and commercialized by Nestlé Health Science S.p.a. It is a liquid drink packaged in a brick of 237 ml. Patients will assume Impact Oral® for 5 days before surgery and 5 day after surgery.
Study: NCT05182606

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Pilot study of algorithms implementation package
Description: The Implementation Bundle will include a link to algorithms in the Electronic Health Record, Smartphrases, audited feedback, and instructions.
Study: NCT06348342

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pelvic Floor Muscle Exercise
Description: Training for PFME will be given orally and will cover the importance of FME and how to do the exercises, as well as the conditions and frequency of doing the exercises. You will be told that the exercise should be done when the bladder is empty, three times a day (morning, noon and evening) and repeated 10 times in each set. In the first week of exercise, the pelvic floor muscles will be contracted for 3 seconds and relaxed for 3 seconds, and will be increased by 1 second each week. It will be explained that from the 8th week onwards, it will be done by contracting for 10 seconds and relaxing for 10 seconds and will continue. It will be stated that the learning process of pelvic floor muscle exercise may take 6 weeks to 6 months. It will be stated that this exercise should be applied throughout their lives for the sustainability of PFM strength. The training is planned to last approximately 20 minutes. PFME will last for two months. Women in menopause will be given an exercise chart.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pelvic Floor Muscle Exercise
Description: Training for PFME will be given orally and will cover the importance of FME and how to do the exercises, as well as the conditions and frequency of doing the exercises. You will be told that the exercise should be done when the bladder is empty, three times a day (morning, noon and evening) and repeated 10 times in each set. In the first week of exercise, the pelvic floor muscles will be contracted for 3 seconds and relaxed for 3 seconds, and will be increased by 1 second each week. It will be explained that from the 8th week onwards, it will be done by contracting for 10 seconds and relaxing for 10 seconds and will continue. It will be stated that the learning process of pelvic floor muscle exercise may take 6 weeks to 6 months. It will be stated that this exercise should be applied throughout their lives for the sustainability of PFM strength. The training is planned to last approximately 20 minutes. PFME will last for two months. Women in menopause will be given an exercise chart.
Study: NCT05091255

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cryotherapy
Description: The procedure involves general or peripheral anesthesia and percutaneous treatment under CT control with probes capable of forming ice spheres of up to 3 cm that will be used in sufficient number to treat the neoplasm completely.
Study: NCT05107037

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TQ-B3234 capsule
Description: TQ-B3234 is an anti-tumor molecular targeted drug, which is a selective Mitogen-activated protein kinase kinase（MEK）1/2 inhibitor
Study: NCT06348342

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Core Exercise
Description: Activating the contraction of the deep core muscles TrA and mutifidus without disrupting breathing forms the basis of core stabilization exercises. To teach the \&#34;abdominal hallowing\&#34; maneuver, which enables the activation of these muscles, patients will be shown a picture of the TrA muscle and asked to contract their lower abdominal muscles while lying on their back in the hook position. During the maneuver, care will be taken to ensure that no movement occurs in the trunk and pelvis and that diaphragmatic breathing continues. After the abdominal hallowing maneuver is taught, the exercises will be progressed gradually. A home exercise program will be given for this. The 7-level exercise program recommended by Hagins et al. will be used as a home exercise program. The movements in this program load more moments on the muscles that stabilize the lumbar spine as the levels progress. The stages of the exercise program are shared in the brochure to be given to the patients.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Core Exercise
Description: Activating the contraction of the deep core muscles TrA and mutifidus without disrupting breathing forms the basis of core stabilization exercises. To teach the \&#34;abdominal hallowing\&#34; maneuver, which enables the activation of these muscles, patients will be shown a picture of the TrA muscle and asked to contract their lower abdominal muscles while lying on their back in the hook position. During the maneuver, care will be taken to ensure that no movement occurs in the trunk and pelvis and that diaphragmatic breathing continues. After the abdominal hallowing maneuver is taught, the exercises will be progressed gradually. A home exercise program will be given for this. The 7-level exercise program recommended by Hagins et al. will be used as a home exercise program. The movements in this program load more moments on the muscles that stabilize the lumbar spine as the levels progress. The stages of the exercise program are shared in the brochure to be given to the patients.
Study: NCT04818801

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Recombinant two-component COVID-19 vaccine (CHO cell)
Description: The spike (S) protein is the main surface antigen of SARS-CoV-2, mediates entry of SARS CoV-2 into cells expressing the angiotensin-converting enzyme 2 (ACE2). The RBD interacts with ACE2 and can generate potent neutralizing anti-RBD antibodies.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Normal saline (0.9% sodium chloride solution),
Study: NCT06400888

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: needle-free subcutaneous injector for Mecbl
Description: needle-free subcutaneous injector for Mecbl

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: intramuscular injection of Mecbl
Description: intramuscular injection of Mecbl
Study: NCT04799587

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Magnet at P6
Description: Magnet applied at P6 and attached with adhesive tape. The P6 pressure point is 2 inches proximal to the flexor retinaculum, between the flexor carpi radialis and palmaras longus.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Magnet applied to arm not at P6 pressure point.
Description: Magnet applied to arm not at P6 pressure point and affixed with adhesive tape.
Study: NCT06228222

Intervention type: PROCEDURE
Intervention: renal biopsy
Description: Renal biopsy will be performed for all patients fulfilling the American College of Rheumatology (ACR) criteria to confirm the diagnosis of lupus nephritis (LN) and to classify the glomerular disease by the revised International Society of Nephrology/Renal Pathology Society (ISN/RPS) 2018 histopathological classification system
Study: NCT06301178

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cholecalciferol
Description: Vitamin D has various critical regulatory roles, including inflammatory control, cellular proliferation and differentiation, and wound healing regulation.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cholecalciferol
Description: Vitamin D has various critical regulatory roles, including inflammatory control, cellular proliferation and differentiation, and wound healing regulation.
Study: NCT06202300

Intervention type: OTHER
Intervention: Inflammation burden
Description: Coronary artery disease patients undergone multimodality imaging with different level inflammation burden

Intervention type: OTHER
Intervention: Inflammation burden
Description: Coronary artery disease patients undergone multimodality imaging with different level inflammation burden
Study: NCT06398041

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood flow restriction training
Description: standard physiotherapy 45 minutes per day, 5 day a week (GAPP) + 2 extra sessions of blood flow restriction training

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Opinions
Description: Healthcare workers in the geriatric rehabilitation ward and patients will be asked on their opinions on GAPP+Care concerning blood flow restriction training

Intervention type: OTHER
Group type: OTHER
Intervention: Opinions
Description: Healthcare workers in the geriatric rehabilitation ward and patients will be asked on their opinions on GAPP+Care concerning blood flow restriction training
Study: NCT06412822

Intervention type: OTHER
Intervention: Blood sampling
Description: Blood sampling

Intervention type: OTHER
Intervention: Blood sampling
Description: Blood sampling

Intervention type: OTHER
Intervention: Urine sampling
Description: Urine sampling

Intervention type: OTHER
Intervention: Urine sampling
Description: Urine sampling
Study: NCT05481437

Intervention type: DRUG
Intervention: Brentuximab Vedotin
Description: Brentuximab Vedotin injection, 50 mg, once every 2 weeks
Study: NCT06576037

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CBP-1019
Description: Given by vein (IV)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CBP-1019
Description: Given by vein (IV)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CBP-1019
Description: Given by vein (IV)
Study: NCT05316467

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intensive Lifestyle Intervention (ILI)
Description: * dietary guidance~* exercise guidance~* lifestyle intervention

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intensive Lifestyle Intervention (ILI)
Description: * dietary guidance~* exercise guidance~* lifestyle intervention

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Megestrol Acetate 160 MG Oral Tablet
Description: enrolled participants will take Megestrol Acetate 160mg daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Megestrol Acetate 160 MG Oral Tablet
Description: enrolled participants will take Megestrol Acetate 160mg daily
Study: NCT05534542

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: exercıse
Description: ıntradıalıtıc core stabılızatıon

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: exercıse
Description: ıntradıalıtıc core stabılızatıon