Study: NCT05678010

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD1390
Description: Dose level 1: 20 Dose level 2: 40 Dose level 3: 60 Dose level 4: 80

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic Body Radiotherapy
Description: Participants will receive Stereotactic Body Radiotherapy/SBRT to 2 sites of metastatic tumors consecutively. The two treatment sites will be randomized to SBRT to one site and SBRT + AZD1390 to the other site. Both sites will receive 30Gy in 5 fractions.