TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06010173

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gadopiclenol
Description: Dose/volume of gadopiclenol to be administered will be calculated based on patient's weight at the dose of 0.05 mmol/kg BW

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gadopiclenol
Description: Dose/volume of gadopiclenol to be administered will be calculated based on patient's weight at the dose of 0.05 mmol/kg BW

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gadopiclenol
Description: Dose/volume of gadopiclenol to be administered will be calculated based on patient's weight at the dose of 0.05 mmol/kg BW

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Comparator
Description: Dose/volume of comparator to be administered will be calculated based on patient's weight at the dose of 0.1 mmol/kg BW
Study: NCT06175013

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sérum PURIFIANT
Description: Application of Sérum PURIFIANT only, twice daily during 112 days

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sérum PURIFIANT in association Sérum BOOSTER
Description: Application of Sérum PURIFIANT twice daily during 112 days AND Application of Sérum BOOSTER before the Serum PURIFIANT, twice weekly
Study: NCT05063110

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Itacitinib
Description: Administration of 300 mg of ITACITINIB per os every day for 30 days.
Study: NCT06061627

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: LOT-CRT group
Description: In addition to the leads implanted in BiVP group, it is also necessary to implant the left bundle branch area pacing(LBBAP) leads~LBBAP includes LBBP and LVSP.~LBBP is defined if fulfilling criterion 1 and at least one in criteria 2:~1. Paced morphology of RBBD in surface lead V1 (QR, Qr, rSr', rSR' or Qrs);~2. One of the following should be met, while the pacing threshold ≤ 1.5V/0.5ms:~   1. Selective LBBP capture pattern appears, with an iso-electrical window between the pacing spike and QRS onset;~  2. When reducing the output voltage, the LVAT undergoes a sudden change of\>10ms;~If criterion 1 is fulfilled but none in criteria 2 is met, the procedure is considered to be left ventricular septal pacing (LVSP).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: BiVP group
Description: Implantation of a LV pacing lead is attempted using the standard-of-care technique first.
Study: NCT06225323

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lidocaine
Description: Patients will receive Lidocaine infusion for 6 hours. After cord clamping and according to ideal body calculate the bolus dose 1.5 mg/kg of lidocaine 1% and complete the dose by normal saline to 20 ml total volume will be given in 10 min.~The infusion dose 1.5 mg/kg/hour of lidocaine 1% for 6 hours in automated syringe pump (aquavesar fixed variable rate 100ml volume) 100 ml then follow up without infusion up to 24 hours.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: Patients will receive normal saline infusion for 6 hours. After cord clamping 20 ml total volume normal saline will be given in 10 min.~The infusion dose 1.5 mg/kg/hour of normal saline for 6 hours in automated syringe pump (aquavesar fixed variable rate 100ml volume) 100 ml then follow up without infusion up to 24 hours.
Study: NCT06551818

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SesZen-Bio Low Dose 1 (350 mg extract)
Description: Mode of Usage: Swallow the capsule whole with a full glass of water without chewing, crushing, or opening it.~Dosage form: Capsule Frequency: One time daily after meal Rout of administration: Oral

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SesZen-Bio Low Dose 1 (150 mg liposomal)
Description: Mode of Usage: Swallow the capsule whole with a full glass of water without chewing, crushing, or opening it.~Dosage form: Capsule Frequency: One time daily after meal Rout of administration: Oral

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SesZen-Bio High Dose 1 (500 mg extract)
Description: Mode of Usage: Swallow the capsule whole with a full glass of water without chewing, crushing, or opening it.~Dosage form: Capsule Frequency: One time daily after meal Rout of administration: Oral

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Mode of Usage: Swallow the capsule whole with a full glass of water without chewing, crushing, or opening it.~Dosage form: Capsule Frequency: One time daily after meal Rout of administration: Oral
Study: NCT05860855

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Augmentative craniotomy
Description: Expansion of the skull

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Decompressive craniotomy
Description: Standard hemicraniectomy
Study: NCT04409392

Intervention type: OTHER
Intervention: Prothestic joint infection due to Staphylococcus lugdunensis
Description: description of prosthetic joint infection with Staphylococcus lugdunensis
Study: NCT06275256

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rezum
Description: The Rezum device is inserted, a needle is deployed, and vapor is injected into the prostate for nine seconds. This vapor disperses between cells, then cools, releases heat, and gently disrupts the prostate's cells. Because of the initial swelling, a catheter is then inserted, which will remain for two to five days.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: iTind
Description: The iTind device is temporarily placed inside the prostatic urethra (the narrowed portion of the prostate), where it slowly expands and exerts gentle pressure at three precise points. The effect of the iTind is to widen the prostatic urethral opening through which urine can now flow more easily.
Study: NCT06757530

Intervention type: DIAGNOSTIC_TEST
Intervention: AI
Description: Using artificial intelligence models to distinguish between patients with lymph node metastasis and those without lymph node metastasis.

Intervention type: DIAGNOSTIC_TEST
Intervention: AI
Description: Using artificial intelligence models to distinguish between patients with lymph node metastasis and those without lymph node metastasis.
Study: NCT06757829

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: inspiratory muscle training and acupucnture like transcutanoeus electrical nerve stimulation
Description: sickle cell disease patients whose number will be 20 patients will be trained with IMT (threshold inspiratory muscle training) and treated with AC-tens. The number of sessions per week will be three sessions for IMT or AC-tens for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles. Also the session of AC-tens will be 45 minute on bilateral Ex-B1 acupoint. the parameters of AC-tens will be four hertz and 200 microsecond pulse duration.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: inspiratory muscle training
Description: sickle cell disease patients whose number will be 20 patients who will trained with IMT (threshold inspiratory muscle training). The number of sessions per week will be three sessions for IMT for 12 weeks. the IMT will be performed for six sets of respiratory training cycles and the set will contain 10 respiratory cycles.
Study: NCT06757842

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness in Students
Description: The mindfulness intervention includes eight 90-minute group sessions held weekly at Universidad de los Andes, co-facilitated by two instructors. One leads the activities, while the other assists with technical aspects, monitors adverse events, and provides participant support. Participants will receive mindfulness worksheets and are required to practice at home for 15 minutes daily. They will have access to an online platform with audiovisual materials to guide their practice and will complete home practice logs online. Skills taught include sitting meditation (focused on breathing, thoughts, emotions, or sensations), body scan meditation, standing meditation, and mindfulness of daily activities. Group discussions will cover topics such as defining mindfulness, managing stress and pain, the difference between mindfulness and being on 'autopilot,' and how perceptions affect stress, as well as the relationship between pain and suffering, and the acceptance of unwanted experiences.
Study: NCT06758115

Intervention type: PROCEDURE
Intervention: Tuina (Massage) Therapy
Description: Operation Method:~Correct abnormal joint alignment - Manipulatively realign the vertebral segments and pelvis affected by scoliosis.~Correct abnormal muscle function - After realigning the vertebral bodies to their normal position, stretch the corresponding tight and shortened muscles while strengthening the muscles that need to be lengthened.~Restore joint stability - After adjusting the vertebrae and muscles, instruct the patient to hold the corrected posture for at least 10 seconds, then relax for 10 seconds. Repeat this cycle 3-5 times.~Restore sensorimotor control - Provide appropriate movement disturbances to patients maintaining the corrected posture to enhance proprioception and motor memory in the corresponding muscles.~The total duration of the manipulation is 20-25 minutes. Treatment is performed twice a week for a total of 12 weeks.

Intervention type: PROCEDURE
Intervention: Tuina (Massage) Therapy
Description: Operation Method:~Correct abnormal joint alignment - Manipulatively realign the vertebral segments and pelvis affected by scoliosis.~Correct abnormal muscle function - After realigning the vertebral bodies to their normal position, stretch the corresponding tight and shortened muscles while strengthening the muscles that need to be lengthened.~Restore joint stability - After adjusting the vertebrae and muscles, instruct the patient to hold the corrected posture for at least 10 seconds, then relax for 10 seconds. Repeat this cycle 3-5 times.~Restore sensorimotor control - Provide appropriate movement disturbances to patients maintaining the corrected posture to enhance proprioception and motor memory in the corresponding muscles.~The total duration of the manipulation is 20-25 minutes. Treatment is performed twice a week for a total of 12 weeks.
Study: NCT06758505

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Strategy Training Only
Description: Participants will receive ten 45-60-minute sessions (two times per week) in person in their residence to address real-world performance with an emphasis on START strategy, task-specific practice, and guided discovery to perform social participation activities. In session 1, participants will be guided to select 3 to 5 meaningful social activities and prioritize them. In sessions 2 - 9, participants will use structured START strategy worksheet to try the selected activity; assess execution (e.g., what went well, what did not); reflect on a plan with specific strategies and to address identified challenges; and try social participation activities again. The interventionist will use guided discovery to support START strategy application and to elicit problem solving skills. This process will be repeated iteratively across sessions. In session 10, participants will summarize lessons learned and generate an action plan for after the intervention.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Strategy Training embedded with Acceptance and Commitment Therapy Principles
Description: Participants will receive ten 45-60-minute sessions (two times per week) in person in their residence to address real-world performance with task-specific practice and an emphasis on psychological processes using ACT principles. In session 1, participants will clarify value-consistent social participation goals for engaging in 3-5 meaningful activities (Do What Matters). In sessions 2-9, participants will be guided applying ACT principles to cope with negative experiences and separate self from thoughts and feelings (Open Up) and practice mindfulness, stimulate awareness, recognize same person with different experiences, and build self-compassion (Be Present). This process (i.e., try an activity that aligns with values and committed actions; assess performance; and reflect on a plan) will be repeated iteratively. In session 10, participants reflect on lessons learned and generate an action plan for after the intervention.
Study: NCT04446949

Intervention type: OTHER
Intervention: Register follow-up
Description: Number of adverse pregnancy outcomes

Intervention type: OTHER
Intervention: Register follow-up
Description: Number of adverse pregnancy outcomes

Intervention type: OTHER
Intervention: Register follow-up
Description: Number of adverse pregnancy outcomes
Study: NCT06451107

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: specific strength training with static neck stretching
Description: The intervention will consist of specific strength training composed of 5 exercises performed with dumbbells: front raises, lateral raises, reverse flies, shoulder shrugs, and wrist extensions. In addition to the following static stretches: stretching towards lateral flexion of the upper part of the trapezius muscle, the scalene muscles, and the sternocleidomastoid muscle on both sides; extension of the extensor muscles; flexion of the flexor muscles; and contralateral flexion and rotation combined with scapular depression of the scalene muscles and elevation of the scapula on both sides, holding each stretch for 10 seconds. This sequence of stretches will constitute one set, with 6 sets performed with a 30-second rest between sets, lasting 8 minutes. Therefore, the intervention will have a total duration of 28 minutes per session, conducting 3 sessions per week.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Specific Strength Training
Description: The intervention will consist of specific strength training comprised of 5 exercises using dumbbells: front raises, lateral raises, reverse flies, shoulder shrugs, and wrist extensions. Four sets will be performed, with a 1-minute rest between sets. Each exercise will be executed for 30 seconds, followed by a 25-second rest between exercises. Three 20-minute sessions will be conducted per week.
Study: NCT05844306

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo \[18F\]-FDG PET-CT

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fludeoxyglucose F-18
Description: Given via injection

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Medical Device Usage and Evaluation
Description: Undergo X1 RMRS PET-CT

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo \[18F\]-FDG PET-CT
Study: NCT06284356

Intervention type: PROCEDURE
Intervention: Laparoscopic Sleeve Gastrectomy
Description: Laparoscopic Sleeve Gastrectomy

Intervention type: PROCEDURE
Intervention: Laparoscopic Sleeve Gastrectomy
Description: Laparoscopic Sleeve Gastrectomy
Study: NCT04739306

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CT-P42
Description: 2mg/0.05 mL by Intravitreal injection

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Eylea
Description: 2mg/0.05 mL by Intravitreal injection
Study: NCT05792176

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Music Training Intervention
Description: The Music Training Intervention (MTI) entails 12-weeks of online instruction to learn to play the ukulele. Participants will be taught the basic information on how to handle and hold the ukulele, musical chords, and popular songs. They will be instructed to play at least 30-minutes a day, five days a week.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Music Listening
Description: Participants randomized to this arm will be asked to listen to their preferred music for at least 30 minutes, 5 days a week. A member of our research team will call them every week to answer any questions they have about the ML protocol. They will be asked to record their experience in a practice log.
Study: NCT06758076

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Lens 1 (ocufilcon D)
Description: 15 minutes of daily wear

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Lens 2 (somofilcon A)
Description: 15 minutes of daily wear
Study: NCT06757647

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Acalabrutinib
Description: Given PO

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo collection of blood samples

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Aspiration
Description: Undergo bone marrow aspiration

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Biopsy
Description: Undergo bone marrow biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging of the Heart
Description: Undergo CMR
Study: NCT05522231

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: fruquintinib+sintilimab
Description: fruquintinib, 5 mg, QD, PO, 2 weeks on/1 week off, 3 weeks/cycle; sintilimab, 200 mg, IV infusion, Q3W, 3 weeks/cycle.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: axitinib / everolimus
Description: axitinib, 5 mg, twice daily (BID), PO, 3 weeks/cycle, dose escalation will be at the investigator 's discretion based on clinical; everolimus, 10 mg, QD, PO, 3 weeks/cycle.

Intervention type: DRUG
Group type: OTHER
Intervention: fruquintinib
Description: fruquintinib, 5 mg, QD, PO, 3 weeks on/ 1 week off, 4 weeks/cycle.
Study: NCT05372549

Intervention type: OTHER
Group type: OTHER
Intervention: Oxidative stress
Description: Oxidative stress occurs as soon as there is an imbalance between pro- / antioxidants, and molecules exhibiting antioxidant properties are at the forefront of fertility treatment and preservation. Oxidated stress will be measured by blood sample

Intervention type: OTHER
Group type: OTHER
Intervention: Oxidative stress
Description: Oxidative stress occurs as soon as there is an imbalance between pro- / antioxidants, and molecules exhibiting antioxidant properties are at the forefront of fertility treatment and preservation. Oxidated stress will be measured by blood sample

Intervention type: OTHER
Group type: OTHER
Intervention: cf-DNA
Description: cfDNA, extracted from blood plasma in samples collected will uncover the potential role of cfDNA as a stress signal released in response to oxidative stress

Intervention type: OTHER
Group type: OTHER
Intervention: cf-DNA
Description: cfDNA, extracted from blood plasma in samples collected will uncover the potential role of cfDNA as a stress signal released in response to oxidative stress

Intervention type: OTHER
Group type: OTHER
Intervention: MAGENTA AI
Description: Non-invasive technique analyzing images of oocytes that can differentiate oocytes with a higher reproductive potential reflective of their quality

Intervention type: OTHER
Group type: OTHER
Intervention: MAGENTA AI
Description: Non-invasive technique analyzing images of oocytes that can differentiate oocytes with a higher reproductive potential reflective of their quality
Study: NCT05133661

Intervention type: DIAGNOSTIC_TEST
Intervention: HPV testing
Description: Interviews will be conducted among women from the general population and HIV+ women after screening for HPV. A small subset of participants will be interviewed after receiving treatment for precancer. HPV test results and outcome of the precancer treatment if indicated will be documented.
Study: NCT04429893

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: magnesium sulphate
Description: assess the pain intensity of magnesium sulphate as an adjuvant to bupivacaine in serratus anterior plane block for modified radical mastectomy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: bupivicaine
Description: assess the pain intensity of magnesium sulphate as an adjuvant to bupivacaine in serratus anterior plane block for modified radical mastectomy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: bupivicaine
Description: assess the pain intensity of magnesium sulphate as an adjuvant to bupivacaine in serratus anterior plane block for modified radical mastectomy
Study: NCT06304246

Intervention type: OTHER
Intervention: Measurement Pain Threshold
Description: Measurement Pain Threshold: Manual dolorimetry will be used to assess the pain threshold in the non-dominant hand of patients in the preoperative waiting room prior to spinal anesthesia. The dolorimeter head will be placed vertically on the wrist of the non-dominant hand, and pressure will be applied with increments of 1 kg/cm2/s. The pressure applied when the patient perceives pain will be recorded in kg/cm2. The measurement will be repeated three times for each patient, and the average will be recorded as the pain threshold value.

Intervention type: OTHER
Intervention: Measurement Pain Threshold
Description: Measurement Pain Threshold: Manual dolorimetry will be used to assess the pain threshold in the non-dominant hand of patients in the preoperative waiting room prior to spinal anesthesia. The dolorimeter head will be placed vertically on the wrist of the non-dominant hand, and pressure will be applied with increments of 1 kg/cm2/s. The pressure applied when the patient perceives pain will be recorded in kg/cm2. The measurement will be repeated three times for each patient, and the average will be recorded as the pain threshold value.

Intervention type: OTHER
Intervention: Measurement of Serum Asprosin
Description: Measurement of Serum Asprosin: For serum asprosin measurements, blood will be drawn in the preoperative waiting room before the application of spinal anesthesia. The blood samples will be centrifuged, and the serum will be stored at -20°C to measure serum asprosin levels. After all patient blood is collected, serum asprosin will be evaluated with a commercially available double antibody sandwich enzyme-linked immunosorbent assay (ELISA) kit.

Intervention type: OTHER
Intervention: Measurement of Serum Asprosin
Description: Measurement of Serum Asprosin: For serum asprosin measurements, blood will be drawn in the preoperative waiting room before the application of spinal anesthesia. The blood samples will be centrifuged, and the serum will be stored at -20°C to measure serum asprosin levels. After all patient blood is collected, serum asprosin will be evaluated with a commercially available double antibody sandwich enzyme-linked immunosorbent assay (ELISA) kit.
Study: NCT05145426

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Low Intensity Focused Ultrasound
Description: Application of LIFU
Study: NCT04628091

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sampling on surgery day
Description: In the morning, the day of the surgery (the patient will be fasting):~* Occipital hair sample (without roots)~* Venous blood sample (3 tubes of 7mL)~During the surgery:~* Sample of 0.5 to 1 cm3 of subcutaneous adipose tissue during laparoscopic umbilical access~* Collection of a portion of Ampulla proximal part and Isthmus distal part in order to obtain a piece of approximately 4 cm long (2cm of ampulla and 2 cm of isthmus) for each tube.
Study: NCT03127111

Intervention type: GENETIC
Intervention: Gene mutations analysis
Description: Genomic DNA extracted from paired fresh-frozen tumor and normal tissues is used for KRAS mutations, BRAF mutations, PIK3A mutations, and EGFR mutations, etc., by sequencing and for MSI analysis by PCR and capillary electrophoresis.