TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06658236

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Proprioceptive Neuromuscular Facilitation
Description: Group A will follow a PNF-based training protocol to enhance strength, flexibility, and coordination. The exercises include two main movement patterns: flexion-abduction-external rotation with the elbow extended and extension-adduction-internal rotation with the elbow extended. These patterns target the muscles around the shoulder and upper chest. A yellow Thera-Band adds light resistance, increasing muscle engagement. The protocol also employs the reversal of antagonists technique, alternating between opposing muscle groups for balanced development and improved coordination. Participants will complete three sets of ten repetitions per session, with a 60-second rest between sets. The program spans 12 weeks, with three weekly sessions, allowing for consistent progress and muscle recovery. This structured approach aims to improve functional mobility and the performance of activities involving similar movements, offering a comprehensive training strategy through PNF and resistance.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Chest Expansion Exercises
Description: Group B participants followed a breathing-coordinated exercise protocol using a yellow Thera-Band to improve upper extremity function. The protocol began with subjects breathing generally at rest. They were then instructed to synchronize their movements with their breathing: performing upper extremity flexion, abduction, and external rotation during inhalation, followed by extension, adduction, and internal rotation during exhalation. This coordination between breathing and movement aimed to enhance muscle activation and control. Each session included three trials of ten repetitions for each exercise, with a 1-minute rest between trials. The protocol was conducted three times per week over 12 weeks. This approach was designed to promote strength, flexibility, and coordination in the upper body while integrating breath control, which may also support relaxation and better movement efficiency. The structured schedule ensures consistent practice and gradual improvement over the 12 weeks
Study: NCT06660446

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise
Description: The lymphoma unit of the Donostia University Hospital (HUD) is part of the Onkofrail project that analyzes the impact of a physical activity in older cancer patients. The Onkofrail study has included everything type of solid tumors and very diverse treatments, which is a limitation methodology that could condition the analysis of the results. Therefore, the need of proposing a new PE project in a homogeneous population such as that of people with lymphoma, the most prevalent hemopathy in our environment, which has a great survival, but present important adverse effects secondary to treatment systemic.
Study: NCT06670313

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: postop Erector spinae plane block
Description: Postoperative ESP block was performed as the control group

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: postop Erector spinae plane block
Description: Postoperative ESP block was performed as the control group
Study: NCT05706376

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Promoting Positive Family Futures
Description: Promoting Positive Family Futures is a group-based program that aims to help parents and their adolescent children (13-16 yrs) cope with chronic violence by developing emotional and cognitive awareness, learning constructive conflict resolution strategies, and developing family-wide emotional security and positive family relationships. Emotional Security Theory is the foundational conceptual model for the program, and as such, the PPFF focuses on promoting family-wide communication and establishing emotional security in both the family and community across multiple sessions.Firmly grounded the cultural context of Palestine, the intervention also incorporates intervention elements derived from social ecological theories of resilience, and cognitive behavioral approaches to coping. In total, the program includes 8 sessions lasting approximately 1.5 hours each.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as Usual
Description: Families assigned to the TAU condition will participate in a common service offered by both PCC and CRS - a weekly adolescent-only support group. Both CRS and PCC conduct extended group programs for children and adolescents (24 sessions at PCC; 25 sessions at CRS).
Study: NCT06311331

Intervention type: DEVICE
Intervention: Total Talus Replacement (TTR)
Description: The restor3d patient-specific TTR Implant and Instrumentation System is designed to replace a native talus bone that has been affected by a disease state or injury. The implant is an additively manufactured Cobalt Chromium alloy (ASTM F3213) construct produced by laser powder bed fusion. The data-driven design of the implant enables the patient to salvage their joint while maintaining ankle range of motion, reducing pain and improving physical function.
Study: NCT05218980

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Olives
Description: Organic olives (provided by Sakellaropoulos Organic Farms; Sparta, Greece)
Study: NCT06674512

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Clinical Pharmacist-led Pharmaceutical Services
Description: Pharmacists developed an intervention plan to reduce DRPs and improve patients' quality of life by assessing patients' medication knowledge, drug-related problems, and adherence problems in the intervention group in the order of urgency, importance, and priority to be addressed. The plan included a list of patients' medication or lifestyle-related problems, a list of programs based on the assessed problems, and other information.
Study: NCT06674187

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Regular
Description: The stoma surgery will be performed using conventional non-molding suturing techniques. The specific steps include:~1. Select an appropriate stoma site, typically within the rectus abdominis muscle.~2. Perform routine suturing around the stoma without additional mesentery shaping.~3. Form the stoma, ensuring a tight fit of the surrounding tissues.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mesenteric Molding Suturing Group
Description: During the stoma surgery, the mesentery will be shaped and sutured to enhance the support around the stoma and reduce the risk of hernia formation. The specific steps include:~1. Select an appropriate stoma site, typically within the rectus abdominis muscle.~2. Separate the mesentery around the stoma and shape it into a sturdy support structure.~3. Use non-absorbable sutures to fix the shaped mesentery to the abdominal wall, forming a sturdy support structure.~4. Form the stoma on the support structure, ensuring a tight fit of the surrounding tissues.
Study: NCT06676085

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nafamostat
Description: Nafamostat combined with unfractionated heparin for anticoagulation

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Heparin
Description: unfractionated heparin for anticoagulation
Study: NCT06543758

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wearable exoskeletal robot
Description: Participants will wear a wearable exoskeletal robot for gait training and undergo 10 sessions of 30-minute gait training over 4 weeks at home or in nearby indoor spaces. Participants will participate in physical function assessments, including the 10-meter walk test, Timed Up and Go (TUG) test, and Berg Balance Scale, both before and after the intervention. Additionally, participants will complete quality of life and depression inventories before and after the intervention.
Study: NCT06673849

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rhythmic Stabilization
Description: Rhythmic Stabilization Program for Children with Cerebral Palsy Objective: Enhance upper extremity strength and stability through rhythmic stabilization exercises.~Program Overview:~Duration: 30-minute sessions Frequency: Once per week for 6 weeks~Exercise Steps:~Positioning: The child positions their upper extremity within their available range of motion.~Isometric Contraction: The child holds an isometric contraction, maintaining the position without movement.~Therapist's Role: Apply resistance that is sufficient to elicit a reaction but not enough to disrupt the isometric contraction.~Progression: Gradually increase the duration of the isometric hold. Increase the amount of resistance applied. Decrease the contact area between the therapist's hands and the child's upper extremity to enhance stability challenges. Monitoring and Adjustments: Assess the child's ability to maintain the contraction and adapt the resistance and support as needed. Encourage the child's engagement.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ball Balancing
Description: Ball Balancing Program Objective: Improve balance and stability. Equipment: 48-inch gymnastic ball~Program Details:~* Duration: 6 weeks~* Frequency: As needed~Steps:~1. Initial Balance:~   * Eyes Open: Balance on hands for 10 seconds.~  * Progression: Increase to 3-5 repetitions of 60 seconds.~2. Eyes Closed: Repeat the above exercise with eyes closed.~3. Variations:~   * Both Hands on One Ball~  * Each Hand on Separate Balls~  * Weaker Arm on One Ball~4. Body Positions: Progress through four body positions with eyes open, then closed.~5. Correction: If the child misses a position, they open their eyes and reposition actively.
Study: NCT06679582

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Luveltamab tazevibulin
Description: Luveltamab tazevibulin is an antibody-drug conjugate (ADC) targeting folate receptor α (FRα or FOLR1). It consists of an IgG1 antibody (SP8166) conjugated to cleavable 3-3-aminophenyl hemiasterlin drug-linkers at 4 sites. The active warhead (SC209) inhibits tubulin polymerization leading to mitotic arrest and cell death.~Other Names:~* STRO-002~* Luvelta

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Luveltamab tazevibulin
Description: Luveltamab tazevibulin is an antibody-drug conjugate (ADC) targeting folate receptor α (FRα or FOLR1). It consists of an IgG1 antibody (SP8166) conjugated to cleavable 3-3-aminophenyl hemiasterlin drug-linkers at 4 sites. The active warhead (SC209) inhibits tubulin polymerization leading to mitotic arrest and cell death.~Other Names:~* STRO-002~* Luvelta
Study: NCT06678828

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ClarityDX Prostate
Description: The ClarityDX Prostate report will be shared for participants randomized into ClarityDX Prostate arm before the healthcare team decided if an MRI and/or biopsy should be done.

Intervention type: DEVICE
Group type: OTHER
Intervention: ClarityDX Prostate, blinded
Description: ClarityDX Prostate will be run for the control participants but the participant and healthcare provider will be blinded to the ClarityDX Prostate results and will be considered for prostate MRI and/or biopsy based on standard of care criteria. Once the care path has been decided upon, the results of the ClarityDX Prostate will be unblinded to the participant's health care team to assess whether there is a change in the decision of the participant's care path.
Study: NCT06684379

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo comparator
Description: A single dose of saline solution 0.9% for infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PRS CK STORM
Description: A single dose of PRS CK STORM (dose A) for infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PRS CK STORM
Description: A single dose of PRS CK STORM (dose B) for infusion.
Study: NCT06683092

Intervention type: OTHER
Intervention: RETRIAL-MH
Description: participants will complete biweekly surveys, from 2 weeks prior to starting VTD to 6 months after, and 2 quarterly surveys (at 9mo and 12mo).

Intervention type: OTHER
Intervention: RETRIAL-Liver
Description: participants will have a liver function test done prior to starting VTD and 28 days after.

Intervention type: OTHER
Intervention: RETRIAL-Neuro
Description: participants will complete a neurological assessment prior to starting VTD and 28 days after.
Study: NCT06685380

Intervention type: OTHER
Intervention: Not applicable- observational study
Description: For observational studies, participants are not assigned an intervention as part of the study

Intervention type: OTHER
Intervention: Not applicable- observational study
Description: For observational studies, participants are not assigned an intervention as part of the study
Study: NCT06690762

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Education
Description: It consists of nutrition, physical activity, stress management, relaxation exercises and defecation training.
Study: NCT06689865

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: HA-HCP
Description: Prescription hearing aid fit by a hearing healthcare professional using audiology best practices.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OTC-HCP
Description: Over-the-counter hearing aids fit by a hearing care professional using audiology best practices.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OTC-R
Description: OTC fit to an individual using some best practices via remote consultation.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: OTC-SF
Description: Self-fit OTC hearing aids without any clinical support from HCPs.
Study: NCT06689852

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Enriched
Description: To be used twice a day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Loceryl 5%
Description: To be used once a week
Study: NCT06691347

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Eye movement desensitization and reprocessing
Description: Psychotherapy with EMDR. A therapist guides the client in recalling distressing events while simultaneously following a stimulus, like a moving light or tapping. The idea is that this bilateral stimulation helps reduce the intensity of the traumatic memory, allowing clients to gain perspective and lessen emotional distress associated with it. The standard treatment protocol includes up to 24 weekly sessions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive therapy for PTSD
Description: Psychotherapy with CT-PTSD. A therapist works with the client to understand how they interpret their trauma and identify distorted thinking patterns that fuel their PTSD symptoms. Through guided discussions, written exercises, and sometimes re-living the trauma in a controlled way, clients learn to reshape these beliefs, gain a more balanced perspective, and reduce symptoms like hypervigilance, flashbacks, and avoidance behaviors. The standard treatment protocol includes up to 24 weekly sessions.
Study: NCT06618664

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-8068
Description: SHR-8068: injection, 50 mg/10 mL, intravenous infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adebrelimab
Description: Adebrelimab: injection, 600 mg/12 mL, intravenous infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Bevacizumab: injection, 100 mg/4 mL, intravenous infusion

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bevacizumab
Description: Bevacizumab: injection, 100 mg/4 mL, intravenous infusion

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Sintilimab
Description: Sintilimab: injection, 100 mg/10 mL, intravenous infusion
Study: NCT06695793

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Interrupted Sutures
Description: The first layer of uterine incision will be closed using individual, separate sutures placed at regular intervals along the incision line. Each suture will be tied independently, ensuring adequate apposition of uterine tissue, followed by a second layer of running continuous sutures.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Locked Sutures
Description: The first layer of uterine incision will be closed using continuous sutures placed along the uterine incision, incorporating a locking technique at specified intervals to prevent unraveling. The knots will be securely tied to maintain tissue approximation, followed by a second layer of running continuous sutures.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Running Continuous Sutures
Description: Double layer closure of uterine incision using running continuous suture used to close the uterine incision without interruption, providing seamless tissue approximation throughout the incision length.
Study: NCT06694116

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: sentinel lymph node biopsy using carbon dye
Description: Sterile Charcoal carbon dye peritumoral injection will be performed around vulvar tumor and inguinofemoral lymph node dissection will be done 20 min later (unilateral or bilateral)
Study: NCT06695624

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Sphenopalatine Ganglion Block
Description: Sphenopalatine ganglion block group 4cc (80mg) 2% lidocaine + 1cc (4mg) dexamethasone in total 5cc volume will be prepared under sterile conditions before the procedure, 2.5 cc will be given to both nostrils. Sphenopalatine ganglion block will be applied by transnasal endoscopic method.
Study: NCT06688643

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ITM group
Description: Patients in the ITM group underwent intrathecal injection with 0.2 mg morphine after admission to the operating room.Mechanical ventilation was initiated in pressure-regulated volume control (PRVC) mode after induction. Ventilator settings (Aestiva; GE Healthcare, Waukesha, Wisconsin, USA) were as follows: tidal volume 6-8 ml kg-1, positive end-expiratory pressure (PEEP) 0 cmH2O, inspiratory-to-expiratory ratio 1:2, respiratory rate 16 beats per minute (BPM), and inspired oxygen concentration 41%.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: EA group
Description: Patients in the EA group underwent epidural anesthesia after admission to the operating room. Following successful epidural puncture, 3 ml of 2% lidocaine was administered. Once the block level was confirmed, the epidural analgesia pump was activated, delivering 8 ml/h of 0.1% ropivacaine.Mechanical ventilation was initiated in pressure-regulated volume control (PRVC) mode after induction. Ventilator settings (Aestiva; GE Healthcare, Waukesha, Wisconsin, USA) were as follows: tidal volume 6-8 ml kg-1, positive end-expiratory pressure (PEEP) 0 cmH2O, inspiratory-to-expiratory ratio 1:2, respiratory rate 16 beats per minute (BPM), and inspired oxygen concentration 41%.
Study: NCT06695000

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: digital CBT-I
Description: The intervention is a digital Cognitive Behavioral Therapy for Insomnia (CBT-I) program, delivered via a mobile application. The program includes structured, self-guided modules focusing on sleep hygiene education, cognitive restructuring, stimulus control, bed time restriction, and relaxation techniques. Each module offers interactive exercises and weekly assignments designed to support behavior change and improve sleep. Participants will receive app-based reminders to encourage regular engagement, with features for tracking progress and adherence throughout the 6 week program.
Study: NCT06689254

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mifepristone 1200 mg daily
Description: Oral tablets

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Oral tablet
Study: NCT06687408

Intervention type: PROCEDURE
Intervention: RATS Group
Description: The participants with centrally located lung cancer in this group were performed sleeve lobectomy in robotic-assisted thoracic surgery (RATS) approach, which has been already applied to these patients in minimally invasive surgical techniques as part of their regular medical care recently.

Intervention type: PROCEDURE
Intervention: VATS group
Description: The participants with centrally located lung cancer in this group were performed sleeve lobectomy in video-assisted thoracic surgery (VATS) approach.
Study: NCT06688123

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-3167
Description: Dose level 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-3167
Description: Dose level 2.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Insulin glargine
Description: Dose level 3.
Study: NCT06690164

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Atorvastatin 40mg Tablet
Description: once a day for 30 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atorvastatin 40mg Tablet
Description: once a day for 30 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Omeprazole 20mg Capsule
Description: once a day for 30 days
Study: NCT05653180

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IBI310
Description: 2mg/kg IV,3 weeks later, 1mg/kg IV Q6W
Study: NCT06686784

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: After School Plus
Description: The afterschool program as usual runs M-H and consists of a variety of clubs from which middle school students chose to enroll for a semester (\~4 months). Clubs are offered on either a M/W or T/H schedule. Students receive a snack in the cafeteria each day before attending their class.~Afterschool plus is the same as Afterschool as Usual with the addition of young adult mentors. Following snack, mentors will lead students in a short emotion regulation exercise including physical activity and breathing exercises. Mentors will prompt students to identify how they are feeling and make connections between the activities they are doing and their mood and then do activities with students in each class. On T/H, \~4 mentors will lead a new DiscoverU  club which is based on behavioral activation principles and spends more time helping students identify and do more activities that improve their mood. The class promotes physical activity as an important strategy for mental health.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: After School Plus
Description: The afterschool program as usual runs M-H and consists of a variety of clubs from which middle school students chose to enroll for a semester (\~4 months). Clubs are offered on either a M/W or T/H schedule. Students receive a snack in the cafeteria each day before attending their class.~Afterschool plus is the same as Afterschool as Usual with the addition of young adult mentors. Following snack, mentors will lead students in a short emotion regulation exercise including physical activity and breathing exercises. Mentors will prompt students to identify how they are feeling and make connections between the activities they are doing and their mood and then do activities with students in each class. On T/H, \~4 mentors will lead a new DiscoverU  club which is based on behavioral activation principles and spends more time helping students identify and do more activities that improve their mood. The class promotes physical activity as an important strategy for mental health.
Study: NCT06689358

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 0.4 ml/kg of 0.5% bupivacaine
Description: 0.4 ml/kg of 0.5% bupivacaine injected into the thoracic paravertebral space