TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT03596476

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Upper gastrointestinal (GI) endoscopy
Description: An upper gastrointestinal (GI) endoscopy will be performed at V1. Four esophageal biopsies will be taken in both the proximal and the distal esophagus.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Wireless pH monitoring
Description: Wireless pH monitoring will be performed at V1. The pH capsule will be clipped into the esophagus during the upper GI endoscopy. The esophageal pH will be recorded for 96 hours (ambulatory recording).

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Post prandial esophageal High Resolution Impedance Manometry
Description: Post prandial esophageal HRIM will be performed at V2. The recording will be started after transnasal insertion of the HRIM probe. A standardized meal will be given to the patient (Big Mac, medium portion of French fries, orange juice). The recording will be realized for one hour after the end of the meal.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: pH-impedance monitoring
Description: 24-h pH-impedance monitoring on PPI will be performed at V3. A transnasal catheter will be inserted into the esophagus and the recording will be performed for 24 hours (ambulatory recording).
Study: NCT01387126

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Novel fibre supplement
Description: The full dose of the study intervention is 15 grams per day.
Study: NCT05235633

Intervention type: DIAGNOSTIC_TEST
Intervention: Assessment of the accomplishment regarding Activities of Daily Living at the end of acute treatment
Description: Participants perform a test battery to assess the capability to accomplish Activities of Daily Living that includes a standardized and validated questionnaire, a parcour with tasks based on Activities of Daily Living and a motor performance test.
Study: NCT05901376

Intervention type: DIAGNOSTIC_TEST
Intervention: MicroRNA
Description: MiR-20a, MiR-21, MiR-106b, MiR-199a, MiR-223

Intervention type: DIAGNOSTIC_TEST
Intervention: MicroRNA
Description: MiR-20a, MiR-21, MiR-106b, MiR-199a, MiR-223
Study: NCT06263374

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Motor imagery of the jaw
Description: Fifty individuals who have undergone orthognathic surgery of the mandible alone or concurrently with the maxilla will be randomly assigned to the experimental group, which involves practicing motor imagery in addition to a self-rehabilitation program and physiotherapy. Patients will be guided to visualize three sets of jaw movements three times a day. Adherence to the program will be monitored by the physiotherapist. The program has been standardized across all participating centers as the study is multicentric.

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Control task (Sudoku or Crossword puzzle)
Description: Fifty individuals who have undergone orthognathic surgery of the mandible alone or concurrently with the maxilla will be randomly assigned to the control group, which involves practicing a control task (completion of Sudoku or crossword puzzles) in addition to a self-rehabilitation program and physiotherapy. Patients will be instructed to engage in the task for approximately 10 minutes per day, equivalent to the duration of motor imagery practice in the group 1. Adherence to the program will be monitored by the physiotherapist. The program has been standardized across all participating centers, as the study is multicentric.
Study: NCT04781686

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Camrelizumab
Description: Camrelizumab (200mg) will be given i.v. on day 1 of each 3-week cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apatinib Mesylate
Description: Apatinib (250mg) will be administered orally once a day .

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: S1
Description: S1 (BSA\<1.25 40mg, BSA \>=1.25-\<1.5 50mg, BSA \>=1.5 60mg) will be administered orally twice daily on days 1-7 of each 3-week cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Docetaxel injection
Description: Docetaxel (75mg/m2 IV.drop) will be administered on day 1 of each 3-week cycle, for six cycles.
Study: NCT05012046

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Orange juice
Description: Matched for volume (240 mL/ 8 oz) of other test beverages. 100% orange juice.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Orange flavoured drink
Description: Matched for volume (240 mL/ 8 oz) of other test beverages. Orange flavoured drink

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Water
Description: Matched for volume (240 mL/ 8 oz) of other test beverages. Water control
Study: NCT06270485

Intervention type: PROCEDURE
Group type: OTHER
Intervention: PEEP
Description: Application of different PEEP-Levels during invasive mechanical ventilation
Study: NCT06231901

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: CO-OP
Description: With a task-specific and goal-focused CO-OP approach; it is aimed to increase one's skills, to teach to use self-generated cognitive strategies, and to encourage generalization and transfer to new situations and activities.
Study: NCT06528314

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Efruxifermin
Description: Administered by subcutaneous injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered by subcutaneous injection
Study: NCT06231901

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: GDT
Description: Goal-directed training included the active implementation of task-specific activities related to the child's functional goals. Focusing on motor learning, GDT is an activity-based approach to therapy that uses meaningful, self-selected goals to provide opportunities for problem solving and indirectly guide the movements necessary to successfully meet task demands

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: traditional occupational therapy
Description: The program included functional one-handed and two-handed training and consisted of advice and treatment aimed at reducing spasticity, improving hand function and activities of daily living, and providing appropriate orthoses. It also includes techniques aimed at improving impairment (e.g., stretching, sensory stimulation) and strengthening activities (e.g., motor training, environmental modification, performing specific target activities) to help participants achieve their individual goals.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: traditional occupational therapy
Description: The program included functional one-handed and two-handed training and consisted of advice and treatment aimed at reducing spasticity, improving hand function and activities of daily living, and providing appropriate orthoses. It also includes techniques aimed at improving impairment (e.g., stretching, sensory stimulation) and strengthening activities (e.g., motor training, environmental modification, performing specific target activities) to help participants achieve their individual goals.

Intervention type: OTHER
Group type: OTHER
Intervention: traditional occupational therapy
Description: The program included functional one-handed and two-handed training and consisted of advice and treatment aimed at reducing spasticity, improving hand function and activities of daily living, and providing appropriate orthoses. It also includes techniques aimed at improving impairment (e.g., stretching, sensory stimulation) and strengthening activities (e.g., motor training, environmental modification, performing specific target activities) to help participants achieve their individual goals.
Study: NCT06344429

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Stellest Lenses
Description: All subjects are recruited and randomized to 3 treatment groups at the baseline visit.~A Group：Stellest Lenses spectacle (ST)

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Stellest Lenses+0.05% atropine
Description: All subjects are recruited and randomized to 3 treatment groups at the baseline visit.~B Group：Combined Treatment

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Single vision Lenses+0.05% atropine
Description: All subjects are recruited and randomized to 3 treatment groups at the baseline visit.~C Group：0.05% Atropine with single vision
Study: NCT04429776

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Drug level testing with feedback provided
Description: Feedback about drug levels in blood provided to participant's site

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Drug level testing with no feedback provided
Description: Testing drug levels in blood but feedback not provided to participant's site
Study: NCT04429607

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Erbium:YAG Laser
Description: Erbium:YAG 2940nm will be performed using single spot, multiple pulses on lesions.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Pulsed Dye Laser
Description: PDL will be performed using settings of 6-10 J/s2 on lesions.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Nd:YAG Laser
Description: Nd:YAG 1064nm will be performed using settings of 60-110 J/s2 on lesions.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Electrodessication and curettage
Description: Electrodessication and curettage will be performed using an epilating needle, followed by curettage on lesions.
Study: NCT04658004

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NKG2D CAR T-cells
Description: Each subject receive NKG2D CAR T-cells by intravenous infusion
Study: NCT04702191

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Triple P
Description: Triple P - level 4 group is a group-based parenting intervention for families with children who exhibit behavioural or emotional difficulties. Group sessions typically focus on topics such as positive parenting, helping children develop, managing misbehaviour, and planning ahead. Practitioners then provide individual feedback on progress using positive parenting strategies and goal setting. Trained practitioners will deliver the program according to the manualized protocol (Turner, Markie-Dadds, \& Sanders, 2010). This will include eight weekly sessions with maximum of 12 parents. The first four sessions will be as group sessions. These four group sessions will be followed by three one-to-one practical and personalised telephone consultations. Finally, there will be one group session, which will complete the programme and parents' contact with the Triple P practitioners. The main aim of this session is to review progress and plan for the future.
Study: NCT04515212

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Optic Nerve Ultrasounds
Description: Patients will have up to four ultrasounds of the optic nerve.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Optic Nerve Ultrasounds
Description: Patients will have up to four ultrasounds of the optic nerve.
Study: NCT04977401

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Endoscopic submucosal dissection
Description: Dissecting superficial gastric or rectal lesion/polyp after injection of the submucosa for lifting, using a electrosurgical knife through the endoscope

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Endoscopic submucosal dissection
Description: Dissecting superficial gastric or rectal lesion/polyp after injection of the submucosa for lifting, using a electrosurgical knife through the endoscope

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: use of Orise Gel as lifting agent for endoscopic submucosal dissection
Description: Injection of some colloidal solution (ORISE gel) in the submucosal layer in order to obtain long lifting effect and thus allowing the endoscopist to dissect under the lesion.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: use of glycerol as lifting agent for endoscopic submucosal dissection
Description: Injection of some colloidal solution (glycerol) in the submucosal layer in order to obtain long lifting effect and thus allowing the endoscopist to dissect under the lesion.
Study: NCT04775953

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cefazolin
Description: Cefazolin is a semisynthetic cephalosporin analog with broad-spectrum antibiotic action due to inhibition of bacterial cell wall synthesis. Cefazolin (2 g will be administrated intravenously (IV) every 8 hours for 4-6 weeks)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dalbavancin
Description: A second-generation lipoglycopeptide antibiotic synthesized from a fermentation product of Nonomuraea species

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Daptomycin
Description: Daptomycin (USA) or Cubicin (Spain) is a cyclic lipopeptide antibiotic that inhibits gram-positive bacteria. Daptomycin (6-10 mg/kg will be administrated intravenously (IV) daily for 4-6 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nafcillin
Description: Nafcillin is a semi-synthetic antibiotic related to penicillin. Nafcillin (2 g will be administrated intravenously (IV) every 4 hours for 4-6 weeks)
Study: NCT05011162

Intervention type: DEVICE
Group type: OTHER
Intervention: Digital ACT
Description: Study participants will receive 12 weeks of Digital Acceptance and Commitment Therapy (ACT).
Study: NCT04551846

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Oligomeric enteral feeding
Description: Oligomeric enteral feeding will be administered to the PICU patients

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Polymeric enteral feeding
Description: Polymeric enteral feeding will be administered to the PICU patients
Study: NCT04698018

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Faster Aspart
Description: Administered s.c. (subcutaneously, under the skin) of the lower abdomen using a pen-injector.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Novo Rapid
Description: Administered s.c. (subcutaneously, under the skin) of the lower abdomen using a pen-injector.
Study: NCT04702191

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Circle of Security Parenting
Description: Circle of Security - Parenting (COS-P) will be delivered according to the protocol outlined by Cooper, Hoffman and Powell (Cooper et al., 2009). COS-P is a manualized eight-session parent-education group program which has the same broad aims and core components of the COS-Intensive model from which it was developed (i.e., to increase caregiver sensitivity and responsiveness to child cues, empathy for the child by supporting parental reflective functioning, recognition and understanding of child attachment cues, and awareness of the impact of the caregiver's own attachment history on caregiving patterns). The program is led by one or two facilitators and includes 10-12 caregivers. The program uses clinical DVD clips of problematic parent-child interaction and healthy alternatives to illustrate attachment patterns and parenting styles, and to promote group discussion.
Study: NCT06167330

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Progressive rehabilitation program
Description: Twelve-week treatment program delivered via eight, up to 1-hour telehealth sessions. The first five sessions will be scheduled every week, and the final three sessions will be scheduled fortnightly. Participants will also be prescribed approximately 15-30 minutes of home activities daily. The treatment program includes pain science education, sensory training, implicit and explicit motor imagery, and mirror therapy. Participants will complete activities at a self-directed pace following a standard progression protocol. Participant adherence will be measured via session attendance and self-report therapy diaries.
Study: NCT05276934

Intervention type: DIAGNOSTIC_TEST
Intervention: Brain computed tomography
Description: This study will use an established local protocol for DCI and intracranial arterial vasospastic stenosis screening, and follow-up to make sure that all patients have the same protocol and don't lose any chance of improvement and good outcome : CT perfusion at different time intervals
Study: NCT04943523

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Krill Oil
Description: Krill oil supplements 4g/day

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Vegetable Oil
Description: vegetable oil supplements 4g/day
Study: NCT05493683

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Disitamab vedotin
Description: 2.0mg/kg，q2w

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tislelizumab
Description: 400mg，q6w
Study: NCT06167330

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Stimulation devices
Description: Twelve-week treatment program delivered via eight, up to 1-hour telehealth sessions. The first five sessions will be scheduled every week, and the final three sessions will be scheduled fortnightly. Participants will also be prescribed approximately 15-30 minutes of home activities daily. The treatment program includes transcutaneous electrical nerve stimulation and cranial electrical stimulation. Participants will complete activities at a self-directed pace following a standard progression protocol. Participant adherence will be measured via session attendance and self-report therapy diaries.
Study: NCT06628180

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LIFU
Description: Application of low-intensity focused ultrasound for neuromodulation

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham LIFU
Description: Sham application of LIFU - will appear the same to participants.
Study: NCT05990829

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ozurdex
Description: Standard 25-gauge pars plana vitrectomy (PPV) will be performed under retrobulbar anaesthesia using high-speed vitrectomy system. Clear all the vitreous hemorrhage and proliferative membrane during PPV operation, panretinal photocoagulation (PRP) should be completed. The vitreous cavity will be filled with balanced salt solution. An injection of Ozurdex will be performed at the end of the surgery.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aflibercept
Description: Standard 25-gauge pars plana vitrectomy (PPV) will be performed under retrobulbar anaesthesia using high-speed vitrectomy system. Clear all the vitreous hemorrhage and proliferative membrane during PPV operation, panretinal photocoagulation (PRP) should be completed. The vitreous cavity will be filled with balanced salt solution. An injection of aflibercept will be performed at the end of the surgery.
Study: NCT06126107

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Brief Normative Feedback
Description: Once a participant has completed the assessment of their drinking during the baseline battery, the participant will receive brief normative feedback about how their drinking compares to their peers.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Brief Normative Feedback
Description: Once a participant has completed the assessment of their drinking during the baseline battery, the participant will receive brief normative feedback about how their drinking compares to their peers.
Study: NCT04775953

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oxacillin
Description: Oxacillin is an antibiotic used in resistant staphylococci infections. Oxacillin (2 g will be administrated intravenously (IV) every 4 hours for 4-6 weeks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vancomycin
Description: Vancomycin is a glycopeptide antibiotic product of the organism Amycolatopsis orientalis. Vancomycin (dose per local standard of care × 4-6 weeks)
Study: NCT06126107

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Brief Normative Feedback
Description: Once a participant has completed the assessment of their drinking during the baseline battery, the participant will receive brief normative feedback about how their drinking compares to their peers.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Loss-framed Text-messaging
Description: Daily text-messages on the consequence of hazardous drinking.
Study: NCT05666141

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Pharyngeal Electrical Stimulation
Description: A Phagenyx catheter is inserted trans-nasally. The catheter design incorporates a nasogastric feeding tube with built-in stimulation electrodes. The intervention consists of 3 PES sessions. A session is a 10-minute stimulation, once per day. The sessions will be given on three consecutive days at optimal parameters.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Pharyngeal Electrical Stimulation
Description: A Phagenyx catheter is inserted trans-nasally. The catheter design incorporates a nasogastric feeding tube with built-in stimulation electrodes. The intervention consists of 3 PES sessions. A session is a 10-minute stimulation, once per day. The sessions will be given on three consecutive days at optimal parameters.
Study: NCT06126107

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Loss-framed Text-messaging
Description: Daily text-messages on the consequence of hazardous drinking.
Study: NCT05666141

Intervention type: DEVICE
Group type: OTHER
Intervention: Pharyngeal Electrical Stimulation
Description: A Phagenyx catheter is inserted trans-nasally. The catheter design incorporates a nasogastric feeding tube with built-in stimulation electrodes. The intervention consists of 3 PES sessions. A session is a 10-minute stimulation, once per day. The sessions will be given on three consecutive days at optimal parameters.
Study: NCT06126107

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Gain-framed Text-messaging
Description: Daily text messages on the benefits of reducing drinking to safe guidelines.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Gain-framed Text-messaging
Description: Daily text messages on the benefits of reducing drinking to safe guidelines.