TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06636526

Intervention type: GENETIC
Intervention: The i4i PRODICT™ test.
Description: The i4i PRODICT™ test combining both common and rare genetic variants into one saliva-based DNA test to estimate a person's future risk of prostate cancer. This test will be offered to all participants in Part 1 of the study. Participants will be classified into high-risk or population risk based on the results of the i4i PRODICT™ test. Those classified as high-risk due to either falling within the high polygenic risk score category, and/or having a rare variant in a gene in the test will be offered targeted prostate cancer screening.

Intervention type: OTHER
Intervention: Prostate cancer screening
Description: Prostate cancer screening in the form of PSA testing will be offered to all participants identified as high risk from the i4i PRODICT™ test for three years in order to track development of cancer in the future.

Intervention type: PROCEDURE
Intervention: MRI Scan
Description: MRI scan will be offered to participants identified in the high-risk category of the i4i PRODICT™ test depending on their PSA test results. Where PSA is above age-specific threshold (\&gt;2.5ug/L for people with prostates (PwPs) aged 40-50 years and \&gt;3.5ug/L for PwPs aged 50-55 years), those with raised PSA levels will be referred for multiparametric MRI at The Royal Marsden Hospital.

Intervention type: PROCEDURE
Intervention: Prostate Biopsy
Description: Transperineal prostate biopsy under local anaesthetic will be offered to to participants identified in the high-risk category of the i4i PRODICT™ test depending on their MRI results. Where a lesion is visible on MRI (defined as a PIRAD score ≥3) onward referral will be made for a transperineal targeted prostate biopsy (or current gold standard NHS practice).
Study: NCT06635213

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Desensitisation
Description: This technique is utilized to decrease, or normalize, the body's response to particular sensations.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Desensitisation
Description: This technique is utilized to decrease, or normalize, the body's response to particular sensations.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Pain neuroscience education
Description: PNE is an educational intervention aiming to alter a patient's beliefs and cognitions regarding their pain experience.
Study: NCT06294184

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: tdcs lDLPFC
Description: The current is 2mA, duration is 1200s, fade in 30s, fade out 30s, anode is on the F3, cathode is on the FP2.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: tdcs rVLPFC
Description: The current is 2mA, duration is 1200s, fade in 30s, fade out 30s, anode is on the F6, cathode is on the FP1.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham
Description: The current only persist in the fisrt 30s, duration is 1200s, fade in 30s, fade out 30s, anode is on the F3/F6, cathode is on the FP2/1.
Study: NCT06008717

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: active subthalamic nucleus deep brain stimulation plus optimal drug therapy
Description: active subthalamic nucleus deep brain stimulation (DBS) plus optimal drug therapy

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: inactive subthalamic nucleus deep brain stimulation plus optimal drug therapy
Description: optimal drug therapy alone with DBS device turned off
Study: NCT06002165

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Usual Care
Description: All clinics in North Carolina Perinatal Region IV have access to Severe HTN Bundle resources on the AIM website (https://saferbirth.org/psbs/severe-hypertension-in-pregnancy) and the locally adapted Outpatient HTN Bundle resources on the North Carolina Perinatal Region IV Provider Support Network website (https://www.mombaby.org/outpatient-bundle-for-severe-hypertension/). At baseline, the clinical leadership of all enrolled sites will receive direct communication via email that describes and provides links to the available resources. This will constitute usual care.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: ACHIEVE Multi-component Implementation Strategy
Description: The intervention is comprised of four implementation strategies: facilitation/coaching, training, simulation, and delivering educational materials. The ACHIEVE study team, primarily the Nurse Coordinator, will engage teams within each clinic to participate in quality improvement activities utilizing these four strategies. The Nurse Coordinator will train the providers/staff on the O-HTN bundle components, facilitate corresponding office systems and workflow changes, and conduct simulations of patients with severe hypertension so care teams can practice the steps involved in recognizing and responding to episodes of severe hypertension in a timely manner.
Study: NCT06384183

Intervention type: DEVICE
Intervention: Kerecis Fish Skin Graft
Description: Patients already treated with a Kerecis device
Study: NCT05347667

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Unilateral Resistance Exercise Leg
Description: One leg will perform unilateral resistance exercise

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Unilateral Resistance Exercise Leg
Description: One leg will perform unilateral resistance exercise

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Control Leg
Description: One leg will serve as a non-exercise control

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Control Leg
Description: One leg will serve as a non-exercise control
Study: NCT05935215

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iptacopan
Description: Open Label
Study: NCT06405581

Intervention type: OTHER
Intervention: Edmonton frailty scale calculation
Description: The frailty status of the patients will be assessed using the Edmonton frailty scale.~According to the Edmonton frailty scale;~* (0-5): not frail~* (6-7): sensitive~* (8-9): slightly fragile~* (10-11): moderately fragile,~* (12-17): extremely fragile

Intervention type: OTHER
Intervention: Edmonton frailty scale calculation
Description: The frailty status of the patients will be assessed using the Edmonton frailty scale.~According to the Edmonton frailty scale;~* (0-5): not frail~* (6-7): sensitive~* (8-9): slightly fragile~* (10-11): moderately fragile,~* (12-17): extremely fragile
Study: NCT06351358

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sculptra treatment
Description: Subjects will receive treatment of Sculptra at baseline. Subjects will receive a second treatment of Sculptra at Week 4 visit. At the Week 8 visit, subjects will receive an optional treatment of Sculptra.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Restylane Treatment
Description: Subjects will receive treatment Restylane Lyft or Restylane Contour at baseline. Subjects will receive an optional touch-up of Restylane Lyft or Restylane Contour at Week 4 visit.
Study: NCT04778033

Intervention type: OTHER
Intervention: Sperm collection
Description: Those recruited will supply a single sperm sample 1-2 months following the second dose of the vaccination. The sample will be analyzed for macroscopic and microscopic features in the IVF laboratory and will be discarded immediately afterwards.
Study: NCT05163574

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: High dose OIT
Description: Patients will receive daily a high dose of peanut flour (300 mg peanut protein) mixed with well-tolerated fruit mousse.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Low dose OIT
Description: Patients will receive daily a low dose of peanut flour (150 mg peanut protein) mixed with well-tolerated fruit mousse.
Study: NCT05882565

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: A brief (14-day) online mindfulness intervention
Description: The content of the online mindfulness intervention is based on studies by Cavanagh et al. (2013, 2018). There is an approximately 10-minute audio tutorial that participants will listen to daily for 14 days. In the first week, participants will be instructed to apply their learned mindfulness skills to their daily activities. In the second week, they will continue practicing by learning to walk in a mindful manner.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Psychoeducation online
Description: The online psychoeducation was modified from the study by Harrer et al (2019, 2021).~This intervention consists of 14 audio tutorials about stress for 14 days, each lasting approximately 10 minutes. Additionally, there is a text version of each audio tutorial, which can be accessed by participants after listening to the audio.
Study: NCT05047926

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral Counseling
Description: Undergo behavioral counseling

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nutritional Supplement Drink
Description: Given Boost or Ensure

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nutritional Supplement Drink
Description: Given Boost or Ensure

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical Activity
Description: Complete physical activity assignments

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical Activity
Description: Complete physical activity assignments

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Survey Administration
Description: Complete surveys

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Survey Administration
Description: Complete surveys

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Survey Administration
Description: Complete surveys

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT scans

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT scans

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood collection

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health Education
Description: Complete Resilient Living program

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health Education
Description: Complete Resilient Living program

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Medical Device Usage and Evaluation
Description: Wear a FitBit
Study: NCT05022030

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: mCapOX plus cetuximab
Description: capecitabine 1000mg/m2 po bid d1-7+oxaliplatin ivgtt 85mg/m2 d1+cetuximab ivgtt 500mg/m2, q2w

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: mFOLFOX6 plus cetuximab
Description: oxaliplatin ivgtt 85mg/m2 d1+ leucovorin ivgtt 400mg/m2 d1+ fluorouracil iv bolus 400mg/m2 d1+ fluorouracil 2400mg/m2 continuous infusion for 46h+cetuximab ivgtt 500mg/m2, q2w
Study: NCT06056024

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 3706674
Description: BI 3706674

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 3706674
Description: BI 3706674

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BI 3706674
Description: BI 3706674
Study: NCT04244032

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Working Memory Training
Description: Participants complete up to 12 sessions of computerized training (30-45 min each) in a working memory task designed to utilize individually-adapted difficulty levels.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Inhibitory Control Training
Description: Participants complete up to 12 sessions of computerized training (30-45 min each) in an inhibitory control task designed to utilize individually-adapted difficulty levels.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Bias Modification Training
Description: Participants complete up to 12 sessions of computerized training (30-45 min each) in a bias modification task designed to utilize individually-adapted difficulty levels.
Study: NCT06332378

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental group 1 :Ball training
Description: Ball training Training in sitting position (the participants sat on the ball and did the exercises): holding balance position on the ball, active movements (flexion, extension, abduction, adduction) of one upper extremity, active movement of two upper extremities, trunk movements (bending forward and rotation), raising heel, raising toes, raising heel and toes simultaneously, resistance against perturbation, and weight shifting on ball and 2-Training in standing position: moving the ball up and down in a straight line with two upper extremities, moving the ball up and down in an oblique line with two upper extremities, moving the ball forward and backward with left and right lower extremities, moving the ball laterally with left and right lower extremities, throwing the ball against the wall with hand, throwing the ball against the wall with foot

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental group 2 :Frenkel Exercises
Description: Frenkel Exercises Supine position~1. Flex and extend one leg, heel sliding down a straight line on table.~2. Abduct and adduct leg with knee and hip extended, leg sliding on table. Sitting position~1. Place foot on therapist's hand, which will change position. 2. Raise leg and put foot on traced footprint on the wall. 3. Rise and sit with knees together. Standing position~1. Place foot forward and backward on a straight line.~2. Walk along a winding strip.~3. Walk between two parallel lines

Intervention type: OTHER
Group type: OTHER
Intervention: Control Group
Description: By using random allocation, the participants will divided into three groups: an intervention group (N=30) that receive ball training exercise, another intervention group (N=30) that receive Frenkel training exercise and a control group (N=30
Study: NCT04805788

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Proton Stereotactic Body Radiation Therapy
Description: Undergo SBPT

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Quality-of-Life Assessment
Description: Ancillary studies
Study: NCT06093516

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Tinted Lenses
Description: Tinted coloured lenses with UV protection within spectacle frames with the intension to help reduce the symptoms of Visual stress.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Tinted Lenses
Description: Tinted coloured lenses with UV protection within spectacle frames with the intension to help reduce the symptoms of Visual stress.
Study: NCT05265546

Intervention type: DRUG
Group type: OTHER
Intervention: Psilocybin
Description: The effects of different doses of psilocybin (0 - 14 mg) will be compared.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: The effects of different doses of psilocybin (0 - 14 mg) will be compared.
Study: NCT06338085

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: emotional liberation technique
Description: In this intervention, with the technique taught by the researcher, women will self-administer the practice of lightly touching certain points 5 days and 1 time per week for 8 weeks. A whatsup group will be created by the researcher. A reminder message will be sent from this group to do the practice 1 time every day.
Study: NCT05922462

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Greek yogurt
Description: For 16 weeks, athletes will consume 2 servings/day of 175 g GY (0% MF, flavoured, 130 calories, 17 g protein, 225 g calcium; e.g., OIKOS High Protein GY)

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Whey protein
Description: For 16 weeks, athletes will consume 2 servings/day of 2/3 of a scoop of commercially available WP powder (flavoured, \~29 g, 120 calories, 19 g protein, 112.5 g calcium; e.g., PURE Whey Protein, Walmart)
Study: NCT06524648

Intervention type: DIAGNOSTIC_TEST
Intervention: niPGT-A
Description: Embryos will be cultured, from oocyte fertilization up to day 6/7 of development, in a time lapse system following the standard practice. On day 6/7, embryos will be vitrified and the embryos's media will be collected for niPGT-A analysis.~Patients will undergo a single embryo transfer (SET) following the niPGT-A report indications. In the event of 1 or more embryos with the same niPGT-A score, the embryo for transfer will be determined by the site standard practice (morphology or time-lapse score).~Patients who do not achieve a pregnancy after a niPGT-A guided SET can undergo as many niPGT-A guided SET or COS+niPGT-A cycles as they need to get pregnant, while the study recruitment phase is active.
Study: NCT06435845

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anti-(integrin beta-3) human monoclonal antibody
Description: human monoclonal anti-human platelet antigen (HPA)-1a immunoglobulin G antibody
Study: NCT06164392

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Indocyanine green
Description: Intravenous administration of indocyanine green followed by fluorescence angiography imaging of the neuroma
Study: NCT06575023

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Tamponade of lower uterine segment in management of placenta accreta spectrum cases
Description: To compare the efficacy of lower uterine tamponade and partial lower myometrial resection in the management of intraoperative bleeding in cases with placenta accreta spectrum

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: partial myometrial resection of lower uterine segment in management of placenta accreta spectrum cases
Description: tamponade vs partial myomertial resection of lower uterine segment in managment of placenta accreta spectrum cases
Study: NCT06063070

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluzoparib Capsules
Description: oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Injectable solution
Study: NCT04575051

Intervention type: OTHER
Group type: OTHER
Intervention: Consult Model
Description: The Consult Model (i.e., usual care) is an acute care strategy, relying on a monthly Audiologist visit to the facility.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Consult Model
Description: The Consult Model (i.e., usual care) is an acute care strategy, relying on a monthly Audiologist visit to the facility.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Engage Model
Description: The Engage Model is a chronic care approach to supportive hearing loss self-management of ARHL. Engage includes (a) hearing screening for all residents, (b) an individualized communication plan for those with an identified hearing loss (e.g., one-to-one, group, telephone, television plans, hearing aid trouble shooting, communication strategies, etc.), (c) provision of simple, non-custom amplifiers, (d) referral to audiology if needed, and (e) ongoing support provided by trained personnel (Communication Facilitator) under the supervision of the audiologist.
Study: NCT06447987

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Allogeneic Hematopoietic Stem Cell Transplantation
Description: Undergo alloHCT

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Aspiration
Description: Undergo bone marrow biopsy and aspiration

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Biopsy
Description: Undergo bone marrow biopsy and aspiration

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CD19CAR-CD28-CD3zeta-EGFRt-expressing Tn/mem-enriched T-lymphocytes
Description: Given IV

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Cetuximab
Description: Given IV

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT and PET

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Given IV

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Echocardiography
Description: Undergo ECHO

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Given IV

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Leukapheresis
Description: Undergo leukapheresis

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Multigated Acquisition Scan
Description: Undergo MUGA

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography
Description: Undergo PET/CT
Study: NCT05616988

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: psychological-clinical intervention with three days of expressive writing by Pennebaker
Description: The psychological-clinical intervention involves five interviews with three days of expressive writing by Pennebaker. During the psychological-clinical interviews the following aspects will be explored:~* Emotions and expectations related to the breast reconstruction process.~* Feelings related to the perception of one's own body image to promote an integration between the image of one's body and the aspects related to one's own identity and femininity.~* Thoughts and feelings related to one's relational and social life.~Expressive writing is a technique devised by Pennebaker (1986), who states that expressing deeper thoughts and feelings through writing can improve the physical and psychological health of the individual. The writing task consists of writing about a traumatic experience or a significant event for the person, for a controlled period (usually 15-30 minutes) and on consecutive days (from 2 to 3 days).
Study: NCT06530862

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: ESWT+stretching exercises
Description: Participants in this group will receive ESWT treatment

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dry needling+stretching exercises
Description: Participants in this group will receive Dry needling treatment
Study: NCT04699279

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rosuvastatin 10mg
Description: Rosuvastatin 10mg is taken by oral or nasal feeding every day at ang time.