Study: NCT06652763

Intervention type: OTHER
Intervention: Minnesota Living with Heart Failure Questionnaire
Description: Self-administered, validated questionnaire to assess symptoms of heart failure

Intervention type: OTHER
Intervention: Minnesota Living with Heart Failure Questionnaire
Description: Self-administered, validated questionnaire to assess symptoms of heart failure

Intervention type: OTHER
Intervention: Minnesota Living with Heart Failure Questionnaire
Description: Self-administered, validated questionnaire to assess symptoms of heart failure

Intervention type: DIAGNOSTIC_TEST
Intervention: Echocardiogram
Description: Resting transthoracic echocardiogram to exclude valvular pathology and the assess indices of systolic and diastolic function and speckle tracking for strain

Intervention type: DIAGNOSTIC_TEST
Intervention: Echocardiogram
Description: Resting transthoracic echocardiogram to exclude valvular pathology and the assess indices of systolic and diastolic function and speckle tracking for strain

Intervention type: DIAGNOSTIC_TEST
Intervention: Echocardiogram
Description: Resting transthoracic echocardiogram to exclude valvular pathology and the assess indices of systolic and diastolic function and speckle tracking for strain

Intervention type: DIAGNOSTIC_TEST
Intervention: Six-minute walk test
Description: Standardised, objective assessment of exercise capacity

Intervention type: DIAGNOSTIC_TEST
Intervention: Six-minute walk test
Description: Standardised, objective assessment of exercise capacity

Intervention type: DIAGNOSTIC_TEST
Intervention: Six-minute walk test
Description: Standardised, objective assessment of exercise capacity

Intervention type: DIAGNOSTIC_TEST
Intervention: Manganese-enhanced MRI and 31-P magnetic resonance spectroscopy
Description: Using a 3-Tesla scanner, 31P magnetic resonance spectroscopy will be performed to obtain information regarding cardiac energetics. An intravenous infusion of manganese dipyridoxyl diphosphate (mangafodipir, MnDPDP) will be commenced at a rate of 1mL/min using a dose of 5µmol/kg (0.1mL/kg).

Intervention type: DIAGNOSTIC_TEST
Intervention: Manganese-enhanced MRI and 31-P magnetic resonance spectroscopy
Description: Using a 3-Tesla scanner, 31P magnetic resonance spectroscopy will be performed to obtain information regarding cardiac energetics. An intravenous infusion of manganese dipyridoxyl diphosphate (mangafodipir, MnDPDP) will be commenced at a rate of 1mL/min using a dose of 5µmol/kg (0.1mL/kg).

Intervention type: DIAGNOSTIC_TEST
Intervention: Manganese-enhanced MRI and 31-P magnetic resonance spectroscopy
Description: Using a 3-Tesla scanner, 31P magnetic resonance spectroscopy will be performed to obtain information regarding cardiac energetics. An intravenous infusion of manganese dipyridoxyl diphosphate (mangafodipir, MnDPDP) will be commenced at a rate of 1mL/min using a dose of 5µmol/kg (0.1mL/kg).

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiovascular magnetic resonance scan
Description: Scan including adenosine stress perfusion

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiovascular magnetic resonance scan
Description: Scan including adenosine stress perfusion

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiovascular magnetic resonance scan
Description: Scan including adenosine stress perfusion