TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06356688

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: paclitaxel polymer micelles and cisplatin combined with Cadonilimab
Description: Paclitaxel polymer micelles:Cycle 1: 230mg/m2, IV ≥3 hours; Cycles 2-4: If the patient has a neutrophil nadir ≥1.0 x 109/L along with a platelet nadir ≥80 x 109/L after Cycle 1 dosing and has not experienced grade II-IV non-hematologic toxicity, then give 260mg/m2, IV ≥3 hours, d1, q3w; Cisplatin: 25mg/m2/d x d1-3, IV drip, q3w; Cadonilimab: 375mg, IV drip, d3, q3w;
Study: NCT05216627

Intervention type: DIAGNOSTIC_TEST
Intervention: Self-administered saliva-based viral testing
Description: Participants will be instructed on how to inactivate the virus and bring their sample to their laboratory's central PCR machine, where they will take an assay test. They will be instructed to collect saliva into a 1.5 milliliter (mL) collection tube containing inactivation buffer (TCEP and EDTA) using a small funnel and inactivate at 95°C for 10 minutes. Participants will then transfer 6ul of saliva into 2 PCR tubes containing amplification master mix and primers, put tubes in a heat block or PCR machine at 65°C for 45 minutes and assess fluorescence using a simple battery-powered fluorescence viewer. Once they assess their sample, they will be instructed to dispose of the saliva sample safely and in accordance with best laboratory practices. No saliva samples will be collected by the research team at any time as part of this study.
Study: NCT06497582

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: zhan-zhuang
Description: zhan-zhuang as a fundamental type of qigong

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: self-acupressure
Description: Self-acupressure as a common type of traditional Chinese medicine therapies
Study: NCT06530719

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib mesylate
Description: Osimertinib mesylate , 80mg QD，until the duration of treatment reaches 3 years, the disease progresses, or other treatment termination criteria are met
Study: NCT05001139

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Relizema ecofoam
Description: DermoRelizema ecofoam, class II a medical device, topical compact mousse, to be applied 2 times per day during the 42 days of study duration
Study: NCT05283590

Intervention type: DIAGNOSTIC_TEST
Intervention: Automated echocardiographic inferior vena cava measurement
Description: Patients will be place in supine position. view: subcostal view, importantly supine is standard position for IVC measurement, the IVC is larger in the right lateral decubitus position and vice versa, alternatively directly through a transhepatic approach. Measures will be performed in the two dimensional mode close to the hepatic vein (1 - 3cm from the IVC connection to the right atrium). The IVC will be measured by MM-Mode manually and with the automated mode (both measures will be recorded. In the manual mode this measure requires concurrent utilization of M-Mode and two dimensional mode
Study: NCT05559697

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sponsor incisional negative pressure wound therapy device and dressing
Description: A sponsor incisional dressing placed on the knee and connected to a sponsor disposable negative pressure therapy device

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Standard of Care incisional negative pressure wound therapy system
Description: The control incisional negative pressure wound therapy system represents the standard of care system and market leader. It consists of a disposable negative pressure therapy device and incisional dressing.
Study: NCT06301295

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Ultarthin bronchoscopy with intratumoral washing
Description: Each subject suspected of early-stage, resectable lung cancer will undergo bronchooscopic procedure. Ultrathin bronchoscope is inserted and placed within tumor under radial EBUS, virtual bronchoscopic navigation, and fluoroscopy guidance. Subsequently, intratumoral washing is performed. After undergoing surgery for suspected early-stage lung cancer, the analysis of next generation sequencing is conducted on intratumoral washing, tissue from surgical specimen, and blood.
Study: NCT06028360

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Progressive Muscle Relaxation
Description: Intervention will be applied for 15-20 minutes 3 consecutive days a week for 1 week

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Progressive Muscle Relaxation
Description: Intervention will be applied for 15-20 minutes 3 consecutive days a week for 1 week

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Virtual Reality Therapy
Description: Therapy through VR will be given for 8 minutes 3 times a week on consecutively for 1 week
Study: NCT06430515

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intratumoral Injection of Chemotherapy
Description: This project intends to investigate the clinical efficacy of intra-tumoural injection of chemotherapeutic agents (e.g. cisplatin, oxaliplatin, etc.)via fine needle aspiration guided by CT or ultrasound in patients with advanced solid cancers to validate the safety and efficacy.
Study: NCT05673525

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcatheter Aortic Valve Implantation (KOKA-VALVE)
Description: Transcatheter Aortic Valve Implantation
Study: NCT04650425

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive tasks
Description: Patients will perform the coffee-tea task and the virtual T-maze task, both in the acute and chronic phase after stroke.
Study: NCT05327764

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Work to rest cycles of 40:20 minutes
Description: Walking in a hot environment for 2 hours with repeated 40 minutes of work and 20 minutes of rest

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Work to rest cycles of 20:10 minutes
Description: Walking in a hot environment for 2 hours with repeated 20 minutes of work and 10 minutes of rest
Study: NCT06010134

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical Therapy Program
Description: Physical Therapy Program plus Whole Body Vibration

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical Therapy Program
Description: Physical Therapy Program plus Whole Body Vibration
Study: NCT05533710

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: erector spinae plane block
Description: Patients will receive ESB. In the lateral decubitus, after skin sterilization, ESP block will be performed at the level of T9

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: transversus abdominis plane block
Description: patients will receive TAP block in supine position after skin sterilization, TAP block will be performed between internal oblique and transversus abdominis muscles
Study: NCT05231707

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: A couples-focused intervention for HIV prevention and care in South Africa
Description: From a sample of 272 male-female couples (544 individuals, 272 men and 272 women) recruited from rural KaZulu-Natal, South Africa, couples will be randomized to receive either individual a package of dyadic counseling and testing (intervention arm) or an attention matched control.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: A couples-focused intervention for HIV prevention and care in South Africa
Description: From a sample of 272 male-female couples (544 individuals, 272 men and 272 women) recruited from rural KaZulu-Natal, South Africa, couples will be randomized to receive either individual a package of dyadic counseling and testing (intervention arm) or an attention matched control.
Study: NCT05945303

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Coronary Artery Bypass Grafting surgery
Description: Assessing the reliability of predicting fluid responsiveness in adults undergoing coronary artery bypass graft surgery using ultrasonography of the internal jugular vein for assessment of vessel distensibilty in relation to stroke volume variation (SVV) measured by electrical cardiometry.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Coronary Artery Bypass Grafting surgery
Description: Assessing the reliability of predicting fluid responsiveness in adults undergoing coronary artery bypass graft surgery using ultrasonography of the internal jugular vein for assessment of vessel distensibilty in relation to stroke volume variation (SVV) measured by electrical cardiometry.
Study: NCT04857411

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Peers LEAD plus HLWD
Description: Combined Peers LEAD and Healthy Living with Diabetes is a culturally-appropriate program to increase medication adherence
Study: NCT06543927

Intervention type: DIAGNOSTIC_TEST
Intervention: serum creatinine
Description: Detection of renal impairment in patients receiving anticoagulants

Intervention type: DIAGNOSTIC_TEST
Intervention: serum creatinine
Description: Detection of renal impairment in patients receiving anticoagulants

Intervention type: DIAGNOSTIC_TEST
Intervention: INR
Description: Detection of bleeding in patients with choronic kidney disease receiving anticoagulants

Intervention type: DIAGNOSTIC_TEST
Intervention: INR
Description: Detection of bleeding in patients with choronic kidney disease receiving anticoagulants
Study: NCT05835583

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The theory based integrated program
Description: The theory-based integrated program is administered by a nurse trained in motivational interviewing.In the 12-hour intervention, this program uses motivational interviewing skills to increase the patient's attitude towards medication, enhance the support of significant others around them, and increase the patient's control over their own behavior.
Study: NCT06041633

Intervention type: DIAGNOSTIC_TEST
Intervention: Clinical
Description: Questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: Clinical
Description: Questionnaire
Study: NCT06056726

Intervention type: PROCEDURE
Intervention: BIB positioning
Description: BIB positioning in obese patients with rectal cancer elegible for neoadjuvant therapy
Study: NCT04669366

Intervention type: DRUG
Intervention: sunitinib
Description: As provided in real world

Intervention type: DRUG
Intervention: axitinib
Description: As provided in real world
Study: NCT06504719

Intervention type: DRUG
Intervention: Antibody-Drug Conjugates
Description: Patients with advanced breast cancer treated with ADCs
Study: NCT06264258

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: DVx-T1D™ app
Description: The intervention group will be introduced to the DVx-T1D™ app and the participants will go home with the tablets that has the game installed. Participants will be asked to play the game for 20 mins or more daily. The aim of the app is to impart good behavioral changes in children with T1D in terms of diabetes education, on how to treat a low or a high blood sugar event and make healthy eating choices.
Study: NCT05539040

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Right Atrial ganglionated plexus ablation
Description: A 3D electroanatomic map of the right atrium will be made. During sinus rhythm, the ablation catheter will be positioned at a spot to test with HFS. The right atrium will be paced at a fixed rate, for up to four beats to ensure that there is no ventricular capture then a short burst of HFS will be synchronized to each paced stimulus for up to 15 trains. This will be performed using a custom-built GP stimulator that has been validated for reproducibility against Grass Stimulator (AstroMed).~All Sites will be marked on the 3D map and the positive sites will be ablated at the end of the mapping. If the patient converts to AF, then DC cardioversion will be performed. If mapping in sinus rhythm is not feasible, HFS will be performed continuously for several seconds to identify atrioventricular dissociating GPs (AVD-GPs).~Every ablated GP site will be re-tested with HFS at the end of the procedure until they are all rendered non-functional.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Holter Monitor
Description: 48 hour Holter monitors will be performed post procedure to monitor for recurrence of AF.~These will be performed at 3, 6, 9, 12 months

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Holter Monitor
Description: 48 hour Holter monitors will be performed post procedure to monitor for recurrence of AF.~These will be performed at 3, 6, 9, 12 months
Study: NCT05940805

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Low-frequency transcranial electrical stimulation; Paraspinous block; Dry needling of spastic upper limb muscles; Muscular functional electrical stimulation (FES)
Description: 1. Low-frequency transcranial electrical stimulation (2/100 Hz) applied through 0.3-mm-diameter and 40-mm-long needles placed subcutaneously on the scalp at the projection of Penfield's motor homunculus and sensory and frontal supplementary motor associative areas.~2. Paraspinous block at the levels of the C5, C6 and C7 vertebrae concordant with spasticity laterality.~3. Dry needling of spastic upper limb muscles, as identified through a thorough physical examination, using 0.3-mm-diameter and 40-mm-long needles.~4. Muscular functional electrical stimulation (FES) in the antagonists of the upper limb muscles with spasticity with the following parameters: 20-Hz frequency, 300-µs pulse width, zero-second ramp time, 5-second stimulation time, and 5-second resting time.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: SHAM Low-frequency transcranial electrical stimulation; Paraspinous block; Dry needling of spastic upper limb muscles; Muscular functional electrical stimulation (FES)
Description: For simulation of transcranial electrical stimulation and FES, electrodes were placed on the scalp and in the upper extremity muscles and were connected to a device similar to the real electric current generator. This device did not transmit any electric current but had blinking lights and produced sound to provide the subjects visual and auditory feedback. To simulate dry needling and paraspinous block, retractile needles were used.
Study: NCT04951791

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SMOFlipid
Description: will receive intravenous infusion of 2ml\\kg of smoflipid 20%, in the internal jugular vein 10 minutes before removal of aortic cross clamp in a constant speed

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Normal saline 0.9%
Description: will receive intravenous infusion of 2ml\\kg of normal saline 0.9%, in the internal jugular vein 10 minutes before removal of aortic cross clamp in a constant speed.
Study: NCT05539040

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pulmonary vein isolation
Description: Transseptal puncture for access into the left atrium will be guided by TOE and fluoroscopy.~ACT will be maintained at 300s with heparin. A 3D electroanatomic map of the left atrium will be created and all PVs will be identified. Touch-up radiofrequency ablation will be performed at electrical gaps around the reconnected PVs until complete PVI is achieved.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Pulmonary vein isolation
Description: Transseptal puncture for access into the left atrium will be guided by TOE and fluoroscopy.~ACT will be maintained at 300s with heparin. A 3D electroanatomic map of the left atrium will be created and all PVs will be identified. Touch-up radiofrequency ablation will be performed at electrical gaps around the reconnected PVs until complete PVI is achieved.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Right cavo-tricuspid and left roof linear ablation
Description: CONTROL ARM (Redo-PVI) only: If all Pulmonary veins are isolated at the start of the procedure, the operator will be allowed to perform a right cavo-tricuspid and left roof linear ablation.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Personal ECG recordings
Description: All patients will be provided with an AliveCor KardiaMobile-6L ECG recorder. The device will continue to be used within its CE-marked and NICE-approved purpose. Patients will be asked to take a daily recording from this, once the blanking period is over, in addition to taking a recording if symptomatic. Patients will submit this to the connected care team at Hammersmith Hospital via a secure NHS.net email address, who will assess the recordings both for the study and clinical purposes.
Study: NCT05604963

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Total Thyroidectomy
Description: Total Thyroidectomy - surgical removal of entire thyroid gland

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Total Thyroidectomy
Description: Total Thyroidectomy - surgical removal of entire thyroid gland

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Hemithyroidectomy
Description: Hemithyroidectomy - surgical removal of partial thyroid gland
Study: NCT05618418

Intervention type: OTHER
Intervention: No intervention
Description: No intervention
Study: NCT05133219

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Occupational Therapy
Description: Occupational therapy is the only profession that helps people across the lifespan to do the things they want and need to do through the therapeutic use of daily activities (occupations). Occupational therapy practitioners enable people of all ages to live life to its fullest by helping them promote health, and prevent-or live better with-injury, illness, or disability.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Occupational Therapy
Description: Occupational therapy is the only profession that helps people across the lifespan to do the things they want and need to do through the therapeutic use of daily activities (occupations). Occupational therapy practitioners enable people of all ages to live life to its fullest by helping them promote health, and prevent-or live better with-injury, illness, or disability.
Study: NCT05539040

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Personal ECG recordings
Description: All patients will be provided with an AliveCor KardiaMobile-6L ECG recorder. The device will continue to be used within its CE-marked and NICE-approved purpose. Patients will be asked to take a daily recording from this, once the blanking period is over, in addition to taking a recording if symptomatic. Patients will submit this to the connected care team at Hammersmith Hospital via a secure NHS.net email address, who will assess the recordings both for the study and clinical purposes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Quality of life questionnaire
Description: A Quality of life questionnaire will be performed at baseline, 6 and 12 months to assess the effect of the procedures on patients quality of life.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Quality of life questionnaire
Description: A Quality of life questionnaire will be performed at baseline, 6 and 12 months to assess the effect of the procedures on patients quality of life.
Study: NCT06402240

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Dialectical Behavior Therapy
Description: Dialectical behavior therapy (DBT) in its fully adherent form is a comprehensive intervention involving individual, group, and phone coaching sessions that addresses complex psychological conditions including suicidality, personality disorders, and post-traumatic stress disorder. Evidence for briefer formats incorporating the group skills training format have been successful for many types of conditions, which includes alcohol and substance use disorders. DBT skills training (DBT-ST) involves structured lessons for learning skills in 5 areas: mindfulness, emotion regulation, distress tolerance, interpersonal effectiveness, and addiction. The current intervention is an internet-delivered version of DBT-ST which aims to teach people the same 5 areas of skills in an online environment with a chatbot and interactive format.
Study: NCT06387992

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Three-dimensional dental acquisition
Description: Consultation with a trained nurse who will perform a three-dimensional dental acquisition using a 3D intraoral camera
Study: NCT06165263

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mobile earthquake education
Description: The mobile earthquake education application was developed to increase high school students\&#39; knowledge about earthquakes through videos, activities or games. In the mobile earthquake education application, there are 4 modules that provide general information about the earthquake and what to do before, during and after the earthquake.
Study: NCT05061498

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Additional Pacing maneuvers
Description: In order to determine the optimal setting for pacemapping in all participants additional pacing maneuvers (output and cycle length) are performed
Study: NCT04851756

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CRet
Description: In prone position, subjects will get a 7 min preparation massage with CRet on resistive mode (80-100W), on the lumbar area, followed by a 5 min preparation massage with CRet on resistive mode (100-120 W) on the hamstrings. Then a 5 min Functional Massage (F.M) with passive anckle dorsiflexion and CRet on resistive mode (110-120 W) will be performed on the gastrocnemius medialis and lateralis, followed by a 4 min F.M with CRet on capacitive mode (180-250VA) on the mentioned area. In supine position, a 5 min F.M with passive knee flexion and CRet on resistive mode (110-140W) will be performed on the rectus femoris, followed by a 4 min F.M with passive knee flexion and CRet on capacitive mode (180-250VA) on the mentioned area. A physiotherapist will monitor the temperature of the patient's treated area every 2 minutes.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham CRet
Description: In prone position, subjects will get a 7 min preparation massage with CRet on resistive mode (0 W), on the lumbar area, followed by a 5 min preparation massage with CRet on resistive mode (0 W) on the hamstrings. Then a 5 min Functional Massage (F.M) with passive anckle dorsiflexion and CRet on resistive mode (0 W) will be performed on the gastrocnemius medialis and lateralis, followed by a 4 min FM with CRet on capacitive mode (0 VA) on the mentioned area. In supine position, a 5 min F.M with passive knee flexion and CRet on resistive mode (0W) will be performed on the rectus femoris, followed by a 4 min F.M with passive knee flexion and CRet on capacitive mode (0VA) on the mentioned area.~A physiotherapist will monitor the temperature of the patient's treated area every 2 minutes.
Study: NCT04761848

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cilostazol 50 MG
Description: Cilostazol 50 MG tablet twice daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo tablet twice daily