TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05588570

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CAT
Description: Treatment includes 12 sessions: 2 caregiver teach sessions, 4 caregiver coach sessions in the child-directed interaction (CDI) phase, and 6 caregiver coach sessions in the DADS (Describe situation, Approach situation, give Direct command for child to join situation, provide Selective attention based on child's performance) phase. Throughout the 12 sessions, caregivers are coached through exposures in which the child is given the opportunity to slowly encounter anxiety-provoking factors. In the first session, caregivers are provided psychoeducation on anxiety and parenting practices and taught PRIDE (praise, reflect, imitate, describe, enjoy) skills, which are aimed at increasing approach behaviors and decreasing avoidant behaviors. In the CDI phase, caregivers are coached live via Bluetooth headset through the PRIDE and active ignoring skills. In the last 5 sessions, caregivers are coached through the DADS protocol while working up the Fear Hierarchy with the child.
Study: NCT06109480

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: High definition transcranial direct current stimulation
Description: tDCS is described as a non-invasive form of brain stimulation that uses a low-intensity, constant current applied directly to the head through scalp electrodes.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham High definition transcranial direct current stimulation
Description: Sham HD-tDCS was delivered using the same protocol and current intensity, but the period of active stimulation was only during the ramp-up and ramp-down periods of 30 and 30 seconds.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: electroconvulsive therapy device
Description: ECT induces brief generalized epileptic seizures by electric current to stimulate the forehead under general anesthesia

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: electroconvulsive therapy device
Description: ECT induces brief generalized epileptic seizures by electric current to stimulate the forehead under general anesthesia

Intervention type: DEVICE
Group type: OTHER
Intervention: electroconvulsive therapy device
Description: ECT induces brief generalized epileptic seizures by electric current to stimulate the forehead under general anesthesia
Study: NCT04356183

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SWET: Supervised Weight loss and Exercise Training
Description: Weight loss will occur via a dietitian-led intervention targeting weight loss over 16 weeks, with weekly weigh-ins and group support sessions. Exercise training will consist of three times per week of an interval-based aerobic program plus twice-weekly resistance training. Both weight loss and exercise training will be supervised to maximize safety and adherence.

Intervention type: OTHER
Group type: OTHER
Intervention: CHAT: Counseling Health As Treatment
Description: Control Arm over 16 weeks.
Study: NCT05464355

Intervention type: PROCEDURE
Intervention: Intraoperative electroencephalography recording
Description: Intraoperative electroencephalography measurements, a non-invasive routine monitoring device used during anaesthesia to measure the brain's electrical activity

Intervention type: PROCEDURE
Intervention: Neurofilament light chain measurement
Description: Measurement of the level of neurofilament light chain in a blood sample

Intervention type: PROCEDURE
Intervention: Tau protein measurement
Description: Measurement of the level of tau protein in a blood sample
Study: NCT06332417

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Ba-Duan-Jin Based Deep Breathing Exercises
Description: Pressing Up to the Heavens: Deep inhales while raising arms, promoting lung expansion.~Drawing the Bow to Shoot the Eagle: Stretching exercises to improve flexibility and posture.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: FET (Forced Expiratory Technique)
Description: The forced expiratory technique sometimes referred to as a 'huff', is used to help force secretions (phlegm) up the throat so it can be removed via the mouth without the pain of coughing.
Study: NCT05483218

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Nocturnal wrist orthosis wearing
Description: Nocturnal wearing of one of the 2 wrist orthosis kind

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Nocturnal wrist orthosis wearing
Description: Nocturnal wearing of one of the 2 wrist orthosis kind
Study: NCT05815979

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: virtual reality
Description: Presentation of the virtual reality glasses and an information meeting will be held for all students in the experimental group, and the working procedure of the virtual reality glasses will be introduced. Afterwards, students will monitor the practice skill at least once using virtual reality glasses. After the completed follow-up, the students will be asked to practice their nasogastric tube application skill on a simple simulation mannequin/model with low reality in the laboratory environment.
Study: NCT06603155

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Time restricted eating (TRE)
Description: TRE is defined as limiting daily food intake to 10 hour period with a nightly fasting period of 14 hours.
Study: NCT06405308

Intervention type: PROCEDURE
Intervention: R-NOSES group
Description: robotic natural orifice specimen extraction surgery

Intervention type: PROCEDURE
Intervention: R-TSES group
Description: robotic transabdominal specimen extraction surgery
Study: NCT06089785

Intervention type: DEVICE
Intervention: elastography
Description: evaluation of degree of spleen stiffness in liver cell failure patient by elastography.
Study: NCT05682222

Intervention type: DRUG
Group type: OTHER
Intervention: EDP1815
Description: EDP1815 is an essentially non-viable, non-replicating pharmaceutical preparation of a single strain of Prevotella histicola, a naturally occurring human commensal microbe.

Intervention type: DRUG
Group type: OTHER
Intervention: EDP1815
Description: EDP1815 is an essentially non-viable, non-replicating pharmaceutical preparation of a single strain of Prevotella histicola, a naturally occurring human commensal microbe.

Intervention type: DRUG
Group type: OTHER
Intervention: EDP2939
Description: EDP2939 is a pharmaceutical preparation of extracellular vesicles.

Intervention type: DRUG
Group type: OTHER
Intervention: EDP2939
Description: EDP2939 is a pharmaceutical preparation of extracellular vesicles.

Intervention type: DRUG
Group type: OTHER
Intervention: Placebo oral capsule
Description: Placebo.

Intervention type: DRUG
Group type: OTHER
Intervention: Placebo oral capsule
Description: Placebo.

Intervention type: DRUG
Group type: OTHER
Intervention: Placebo oral capsule
Description: Placebo.

Intervention type: DRUG
Group type: OTHER
Intervention: Placebo oral capsule
Description: Placebo.
Study: NCT05168111

Intervention type: DIAGNOSTIC_TEST
Intervention: Detect the serum sample
Description: Detect the serum sample

Intervention type: DIAGNOSTIC_TEST
Intervention: Detect the serum sample
Description: Detect the serum sample
Study: NCT05788016

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: opioid taper
Description: The participant will attempt to taper their opioid dose by \~50% during the 4-6 week preoperative period
Study: NCT06046300

Intervention type: DIAGNOSTIC_TEST
Intervention: Investigation of the relationship between trunk position sense and muscle activation, balance and quality of life in individuals with transtibial amputation.
Description: It is aimed to investigate whether the trunk position sense, including the trunk right and left sides of the individuals with transtibial amputation, is affected and the relationship between trunk position sense and muscle activation, balance and quality of life.

Intervention type: DIAGNOSTIC_TEST
Intervention: Investigation of the relationship between trunk position sense and muscle activation, balance and quality of life in individuals with transtibial amputation.
Description: It is aimed to investigate whether the trunk position sense, including the trunk right and left sides of the individuals with transtibial amputation, is affected and the relationship between trunk position sense and muscle activation, balance and quality of life.
Study: NCT05816499

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cadonilimab
Description: Given IV, 10mg/kg Q3W

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anlotinib
Description: oral，6mg/8mg/10mg qd 2W/3W

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Docetaxel
Description: Given IV, 60-75mg/m2 Q3W
Study: NCT05140824

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 0.9% sodium chloride solution

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TJ202 injection
Description: TJ202 injection
Study: NCT05191914

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide+ Fulvestrant
Description: Drug: Chidamide chidamide 30mg orally，Biw~Drug: Fulvestrant Fulvestrant 500mg i.m. injections every 28 days (Cycle n Day 1) with 1 additional dose on Day 15 of Cycle 1
Study: NCT05243693

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Brentuximab vedotin
Description: 3 cycles of Brentuximab vedotin and DHAP
Study: NCT05439005

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexmedetomidine
Description: Dexmedetomidine+Lidocaine
Study: NCT06240416

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Low speed drilling without irrigation
Description: Low-speed drilling (50 rpm) irrigation to perform the osteotomy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: High speed drilling with irrigation
Description: High-speed drilling (800 rpm) irrigation to perform the osteotomy
Study: NCT05625555

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketamine
Description: IV Ketamine infusion 0.5mg/kg over 40 minutes

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Midazolam
Description: IV Midazolam infusion 30μg/kg over 40 minutes
Study: NCT04814199

Intervention type: OTHER
Intervention: Algorithm
Description: Patients will have a printed algorithm to follow while they are in labour with an epidural for pain management.
Study: NCT06284824

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Stryker Triathlon with MAKO Robotic-Arm
Description: Implant is the Stryker Triathlon total knee arthroplasty and the robotic device is the MAKO robotic-arm

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: DePuy Attune with VELYS Robotic-Assistance
Description: Implant is the DePuy Attune total knee arthroplasty and the robotic device is the VELYS robotic-assistance
Study: NCT06415500

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NK042
Description: NK042 intraperitoneal infusion on Days 0,7 and 14.
Study: NCT06017037

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Citalopram 20mg
Description: Citalopram 20mg tablets, encapsulated to aid blinding. To take per oral once daily for 7-9 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Lactose monohydrate tablets encapsulated to aid blinding. To take per oral once daily for 7-9 days
Study: NCT06457906

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Experimental group (SRS/SRT/Hypo-RT)
Description: The prescription dose of SRS/SRT is 18-22Gy in 1 fraction, 27Gy in 3 fractions and 30Gy in 5 fractions. The prescription dose of Hypo-RT is 40Gy in 8 fraction. The prescription dose could be adjusted if lesions are located in brain stem when treat with SRS/SRT/Hypo-RT.

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Controled group (HA-WBRT)
Description: The prescription dose of HA-WBRT is 30Gy in 10 fraction.
Study: NCT05300204

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Self-help strategies for depression
Description: Before starting the intervention, the participants are told that they will be shown parts of a website about depression. The participants are instructed to carefully attend to the website (e.g., to read the text precisely, to hear attentively to the podcasts and to view carefully the videos and images on the website). The time window spent for the reception of each part of the website are fixed.~The participants in this intervention group will only be shown parts of the website regarding self-help strategies for depression.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: General information about depression
Description: Before starting the intervention, the participants are told that they will be shown parts of a website about depression. The participants are instructed to carefully attend to the website (e.g., to read the text precisely, to hear attentively to the podcasts and to view carefully the videos and images on the website). The time window spent for the reception of each part of the website are fixed.~The participants in this intervention group will only be shown parts of the website regarding general information about depression
Study: NCT05054387

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Agalsidase beta
Description: Powder for concentration into a solution Intravenous (IV) infusion
Study: NCT05569590

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propolis
Description: Vital tooth bleaching will be performed and Propolis as a desensitizing agent will be applied after bleaching to reduce dentine hypersensitivity.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propolis
Description: Vital tooth bleaching will be performed and Propolis as a desensitizing agent will be applied after bleaching to reduce dentine hypersensitivity.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: hydrogen peroxide 35%
Description: hydrogen peroxide 35%

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: hydrogen peroxide 35%
Description: hydrogen peroxide 35%

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: hydrogen peroxide 35%
Description: hydrogen peroxide 35%

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: fluoride varnish
Description: fluoride varnish
Study: NCT05249517

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pain Neuroscience Education
Description: Pain Neuroscience Education (PNE) is a patient education approach that explains in detail the neurobiology, neurophysiology of pain, and the processing of pain by the nervous system in the management of chronic pain.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Progressive submaximal exercise program
Description: It has been shown that the long-term results of the use of PNE in addition to physiotherapy are more effective in reducing pain and disability. It has been reported that progressive submaximal exercise program including cervicothoracic strengthening, endurance, flexibility, and coordination exercises has positive effects on chronic neck pain, related disability, quality of life and mood.
Study: NCT05149885

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SenseGuard monitoring
Description: All subjects that recruited to the study will undergo MCT as usual with the addition of SG measurement after each Methacholine dose and spirometry test.
Study: NCT04834089

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AntiSARS-CoV-2 Serum
Description: Stage A: 30 kidney transplanted participants (very high risk), where 15 will received 1 vial (5 mL) and 15 will received 2 vials (10 mL) of serum; Stage B: 30 immunocompetent participants with at least 2 risk factors for severe disease (high risk) who will receive the dose selected by stage A; Stage C: 558 participants, of very high risk and high risk, compared with placebo in allocation 2:1.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AntiSARS-CoV-2 Serum
Description: Stage A: 30 kidney transplanted participants (very high risk), where 15 will received 1 vial (5 mL) and 15 will received 2 vials (10 mL) of serum; Stage B: 30 immunocompetent participants with at least 2 risk factors for severe disease (high risk) who will receive the dose selected by stage A; Stage C: 558 participants, of very high risk and high risk, compared with placebo in allocation 2:1.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AntiSARS-CoV-2 Serum
Description: Stage A: 30 kidney transplanted participants (very high risk), where 15 will received 1 vial (5 mL) and 15 will received 2 vials (10 mL) of serum; Stage B: 30 immunocompetent participants with at least 2 risk factors for severe disease (high risk) who will receive the dose selected by stage A; Stage C: 558 participants, of very high risk and high risk, compared with placebo in allocation 2:1.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Saline solution Administration Route: Intravenous
Study: NCT06345300

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Liposomal Irinotecan, Oxaliplatin, 5-Fluorouracil/Calcium folinate in combination with Camrelizumab
Description: The treatment regimen for this study is as follows:~Intravenous infusion of Oxaliplatin at a dose of 85mg/m2 for 2 hours or according to clinical practice at the research center;~Intravenous infusion of liposomal Irinotecan at a dose of 60mg/m2 for 90 minutes (±30 min);~Intravenous drip of Calcium folinate at a dose of 400mg/m2 for 30 minutes or according to clinical practice at the research center;~Intravenous infusion of 5-Fluorouracil at a dose of 2400mg/m2 (infused for 46-48 hours or according to clinical practice at the research center);~Camrelizumab at a fixed dose of 200mg, administered via intravenous drip, with each infusion lasting no less than 30 min and no more than 60 min. Administered on day 1 of every 2-week cycle (d1, q2w).~Each treatment cycle is 14 days, and all drugs are administered on day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Liposomal Irinotecan, Oxaliplatin, 5-Fluorouracil/Calcium folinate
Description: The treatment regimen for this study is as follows:~Intravenous infusion of Oxaliplatin at a dose of 85mg/m2 for 2 hours or according to clinical practice at the research center;~Intravenous infusion of liposomal Irinotecan at a dose of 60mg/m2 for 90 minutes (±30 min);~Intravenous drip of Calcium folinate at a dose of 400mg/m2 for 30 minutes or according to clinical practice at the research center;~Intravenous infusion of 5-Fluorouracil at a dose of 2400mg/m2 (infused for 46-48 hours or according to clinical practice at the research center); Each treatment cycle is 14 days, and all drugs are administered on day 1.
Study: NCT04349046

Intervention type: DEVICE
Intervention: Total hip arthoplasty (THA)
Description: Total hip arthroplasty (THA) is a common operative treatment where an arthritic, degenerative or fractured hip joint is replaced with a prosthetic device if conservative options are unable to relieve pain and debilitating symptoms. THA was traditionally performed on patients over 60 years old, but now includes young and active patients, as well as very old ones thanks to the continuous improvement in implant design. Major indications of THA include osteoarthritis, rheumatoid arthritis, avascular necrosis and hip fractures. The THA surgical procedure involves replacing the head of the femur and acetabulum or socket with an artificial prosthesis. This system is composed of a femoral stem that is inserted into the femoral canal, a ball that attaches to the femoral stem, and an acetabular component or shell that replaces the acetabulum.
Study: NCT05572034

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Electrophysiological study
Description: Electrophysiological study: patients in a fasting state and under total intravenous anesthesia Intracardiacelectrogramsare displayed simultaneously on a multichannel recorder. Programmed atrial and ventricular stimulation are performed to rule out sustained arrhythmias, primary conduction system dysfunction, and sick sinus syndrome.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Electrophysiological study and Right side Ganglionated Plexi ablation
Description: Electrophysiological study: patients in a fasting state and under total intravenous anesthesia Intracardiacelectrogramsare displayed simultaneously on a multichannel recorder. Programmed atrial and ventricular stimulation are performed to rule out sustained arrhythmias, primary conduction system dysfunction, and sick sinus syndrome.~GP Mapping and Cardiac denervation: Specific atrium sites are empirically identified as GP by presumed anatomic location based on previous works (anatomic mapping):~In the RA: the posterior aspect of the interatrial septum, between the posterior wall and coronary sinus ostium; and, the septal aspect of the superior vena cava junction (opposite to the LA GP tags).~A 3.5-mm irrigated tip catheter will be used to deliver radiofrequency energy (50°C, 20-30 W, for 30-60 seconds) with a 17 mL/min irrigation flow.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Electrophysiological study and bi-atrial Ganglionated Plexi ablation
Description: Electrophysiological study: patients in a fasting state and under total intravenous anesthesia Intracardiacelectrogramsare displayed simultaneously on a multichannel recorder. Programmed atrial and ventricular stimulation are performed to rule out sustained arrhythmias, primary conduction system dysfunction, and sick sinus syndrome.~GP Mapping and Cardiac denervation: Specific atrium sites are empirically identified as GP by presumed anatomic location based on previous works(anatomic mapping):~In the LA: the inferior right GP (septal aspect of the right pulmonary veins \[PV\]) antra, and LA posterior wall. In the RA: the posterior aspect of the interatrial septum, between the posterior wall and coronary sinus ostium; and the septal aspect of the superior vena cava junction (opposite to the LA GP tags).~A 3.5-mm irrigated tip catheter will be used to deliver radiofrequency energy (50°C, 20-30 W, for 30-60 seconds) with a 17 mL/min irrigation flow.
Study: NCT04930575

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Muscle Energy Technique
Description: A biomechanical correction approach can lead to the normalization of spinal curvatures and a decrease in the compressional and tensional stress on joints and soft tissues of the body.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mulligan Technique
Description: * The patient will be in a supportive low back chair, thus cervical region will be in a vertical position (Weight-bearing position) with the therapist position will be behind the patient.~* Then the therapist will move the spinous process up in the direction that must follow the apophyseal joint plane under treatment, that is, toward the eye ball. While sustaining this pain-free accessory glide, the patient will be instructed to actively perform the physiological movement gradually until the end ROM with over pressure at the end of the range.
Study: NCT05348278

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Urea cream
Description: apply 10% urea cream at both hands and feet twice daily