TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06039631

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgery
Description: In the surgical group, patients will undergo curative surgery for laryngeal/hypopharyngeal cancer along with cervical lymph node dissection. Organ preservation surgery is recommended.

Intervention type: RADIATION
Group type: OTHER
Intervention: Radiation
Description: In the surgical group, depending on postoperative pathology results, adjuvant radiotherapy or concurrent radiochemotherapy may be administered as deemed necessary. If postoperative pathology indicates extracapsular invasion of lymph nodes or positive surgical margins, concurrent radiochemotherapy based on cisplatin is recommended.~In the concurrent radiochemotherapy group, patients will undergo target delineation based on the scope before induction chemotherapy. Radiotherapy will be administered at a total dose of 70 Gy over 35 fractions, and concurrent chemotherapy will involve weekly administration of cisplatin at a dosage of 30 mg/m².

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Radiation
Description: In the surgical group, depending on postoperative pathology results, adjuvant radiotherapy or concurrent radiochemotherapy may be administered as deemed necessary. If postoperative pathology indicates extracapsular invasion of lymph nodes or positive surgical margins, concurrent radiochemotherapy based on cisplatin is recommended.~In the concurrent radiochemotherapy group, patients will undergo target delineation based on the scope before induction chemotherapy. Radiotherapy will be administered at a total dose of 70 Gy over 35 fractions, and concurrent chemotherapy will involve weekly administration of cisplatin at a dosage of 30 mg/m².

Intervention type: DRUG
Group type: OTHER
Intervention: Toripalimab
Description: In the both groups, starting three weeks after the completion of radiotherapy, patients will receive adjuvant immunotherapy using a specific protocol of toripalimab at a dose of 240 mg every 3 weeks for a total of 8 cycles.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab
Description: In the both groups, starting three weeks after the completion of radiotherapy, patients will receive adjuvant immunotherapy using a specific protocol of toripalimab at a dose of 240 mg every 3 weeks for a total of 8 cycles.
Study: NCT05696587

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multimodal rehabilitation
Description: The multimodal rehabilitation program included comprehensive therapy 5 times a week during the 4 weeks between assessments. The therapy consists of:~* Individual physical therapy focused on improving range of motion and alleviating pain in the affected limb;~* Mechanical desensitization;~* Transcutaneous electric nerve stimulation (TENS) electrotherapy;~* Aquatherapy (arm or leg whirlpool bath of the affected extremity);~* Graded Motor Imagery, including the Recognise™ app and mirror therapy;~* Psychoeducation on relaxation and coping with chronic pain.
Study: NCT06303271

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Vagus Nerve Stimulation (VNS) and Caw Thorne Cooksey
Description: Study will be conducted after the approval of Ethical review board. After the initial evaluation will be done on participants underlying eligibility criteria. Experimental group will received intervention of 30 minutes daily for 4 weeks (16 sessions). Assessment was done at the baseline, after 2 weeks and after 4 weeks. Intervention Group received non-invasive vagus nerve stimulation at left auricle (because of anatomy of vagus nerve as right VN innervate SA node which is regulating heartbeat and left VN innervates AV node which is responsible for controlling timing of heartbeat) of ear. VNS group received vagus nerve stimulation via Med Fit vagus nerve stimulator at auricle of left ear only as stimulation of right auricular branch of vagus nerve can result in bradycardia. Frequency of stimulation was kept between 15-30Hz. Intensity was gradually increased according to patient's tolerance. The participant was able to withdraw from the trial if he could not tolerate the stimulation

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Caw Thorne Cooksey
Description: Study will be conducted after the approval of Ethical review board. After the initial evaluation will be done on participants underlying eligibility criteria. The control group will intervention of 30 minutes daily for 4 weeks (16 sessions). Caw Thorne Cooksey exercises were carried out during the stimulation of vagus nerve. Although no adverse effects had been reported during the stimulation of left auricular branch of vagus nerve but a pulse oximeter was used during the stimulation to monitor the heart rate.
Study: NCT05784831

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Reappraisal training
Description: The EMI developed and tested here is based on theoretical and empirical findings and consists of several items and repeated training using various individual scenarios from participants' life that will be presented to participants via an app on their smartphones.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Reappraisal training
Description: The EMI developed and tested here is based on theoretical and empirical findings and consists of several items and repeated training using various individual scenarios from participants' life that will be presented to participants via an app on their smartphones.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Ecological Momentary Assessment
Description: The EMA tested here collects data on participants' mood and behavior.
Study: NCT04940403

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Burt
Description: 18 one-hour sessions of unimanual upper-limb tasks during robot-assisted training with the Burt.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Burt + BurtVision
Description: 18 one-hour sessions of combination of unimanual and bimanual upper-limb tasks during robot-assisted training with the BurtVision.
Study: NCT05032989

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Extraction of mandibular 3rd molar via Cowhorn forcep technique
Description: Cowhorn forceps technique used to extract the tooth results in less post operative pain and swelling also it makes the extraction easier.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Extraction of mandibular 3rd molar via conventional technique
Description: Conventional method of extraction uses dental elevator and forceps resulting in post operative pain and swellig.
Study: NCT05007080

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Ad26.COV2.S will be administered as intramuscular (IM) injection.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Ad26.COV2.S will be administered as intramuscular (IM) injection.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Ad26.COV2.S will be administered as intramuscular (IM) injection.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Ad26.COV2.S will be administered as intramuscular (IM) injection.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Ad26.COV2.S will be administered as intramuscular (IM) injection.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ad26.COV2.S
Description: Ad26.COV2.S will be administered as intramuscular (IM) injection.
Study: NCT05258604

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: endoscopic band ligation
Description: endoscopic band ligation will be carried out using a Saeed Multi-Band Ligator (Cook Medical, WinstonSalem, NC), and ligation bands were placed on the GAVE.
Study: NCT05184712

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ivonescimab (SMT112 or AK112) Injection
Description: Subjects will receive Ivonescimab (SMT112 or AK112) Plus Pemetrexed and Carboplatin via intravenous infusion (IV) Q3W, up to 4 cycles. Afterward, Ivonescimab (SMT112 or AK112) Plus Pemetrexed will be used for maintenance treatment (administered on Day 1 of each cycle, Q3W) up to 2 years.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Injection
Description: Subjects will receive Placebo Plus Pemetrexed and Carboplatin via intravenous infusion (IV) Q3W, up to 4 cycles in treatment periods per the randomization schedule. Afterward, Placebo Plus Pemetrexed will be used for maintenance treatment (administered on Day 1 of each cycle, Q3W) up to 2 years.
Study: NCT06292468

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional physical therapy
Description: This group received 30 minutes of muscle stretching (quadriceps, gastrocnemius, hamstrings, tibialis), bilateral ankle strengthening, gait training and foot care guidelines, 3 times a week for a duration of six weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Plantar cutaneous sensory stimulation
Description: This group received 45 minutes of plantar cutaneous sensory stimulation, TENS, muscle stretching (quadriceps, gastrocnemius, hamstrings, tibialis), bilateral ankle strengthening, gait training, and foot care guidelines, 3 times a week for a duration of six weeks.
Study: NCT06295198

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Single lep drop jump test
Description: All evaluations will be repeated before and after the treatment.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Single lep drop jump test
Description: All evaluations will be repeated before and after the treatment.
Study: NCT05365360

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LaserCap SD
Description: LaserCap SD

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham LaserCap
Description: Sham LaserCap

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LaserCap HD+
Description: LaserCap HD+
Study: NCT06086600

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Instrument Assisted Soft Tissue Mobilization
Description: give gentle strokes from proximal to distal to check for trigger point or taut band. After knowing the exact location, give gentle strokes with minimal pressure in all directions by keeping the instrument in 30 to 60 degree angle. Application time will be between 40- 120 seconds.~Conventional treatment will include~* Hot pack for 10-15 min (calf muscles)~* Stretching exercises of gastro-soleus (10reps x 2Sets).~* Post session : Cold pack for 5 minutes (calf muscles)

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dynamic oscillatory stretch technique
Description: Passively dorsiflexe the ankle to a point of the first stretch sensation. The next component to DOS, 2- second, passive stretch with slow oscillations at end range was applied. This procedure is repeated 10 times in each set with total of 3 sets .Therefore,10reps x2 second hold oscillation x 3 sets are given.Conventional treatment will include~* Hot pack for 10-15 min (calf muscles)~* Stretching exercises of gastro-soleus (10reps x 2Sets).~* Post session : Cold pack for 5 minutes (calf muscles
Study: NCT05734469

Intervention type: OTHER
Group type: OTHER
Intervention: Forefoot bone surgery
Description: Elective forefoot bone surgery under popliteal sciatic nerve

Intervention type: OTHER
Group type: OTHER
Intervention: Forefoot bone surgery
Description: Elective forefoot bone surgery under an ankle block
Study: NCT04677829

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: PNT001
Description: 30 minute infusion for PNT001 1000mg; 60 minute infusion for PNT001 4000mg

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: PNT001
Description: 30 minute infusion for PNT001 1000mg; 60 minute infusion for PNT001 4000mg

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: %5 dextrose for infusion
Description: 30 min placebo infusion for 1000mg; 60 minute placebo infusion for 4000mg

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: %5 dextrose for infusion
Description: 30 min placebo infusion for 1000mg; 60 minute placebo infusion for 4000mg
Study: NCT05697952

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: E1K 1,200 ㎍/joint
Description: Injection of E1K 1,200 ㎍/joint/ml on target lesion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: E1K 2,400 ㎍/joint
Description: Injection of E1K 2,400 ㎍/joint/ml on target lesion

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: Injection of 3ml saline on target lesion
Study: NCT04775199

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Language Intervention
Description: The examiners will target vocabulary and grammar in the context of preschool science instructions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Language Intervention
Description: The examiners will target vocabulary and grammar in the context of preschool science instructions.
Study: NCT05347368

Intervention type: OTHER
Group type: OTHER
Intervention: Control group (conventional therapy)
Description: Physical therapy will be performed using physical agent modality that include hot pack (15 min), and therapeutic exercises (5 repetition per set, 2 sets each session) therapeutic exercises include spinal extension exercise, prone hip extension exercise, posterior pelvic tilt, cat-camel exercise

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Control group (conventional therapy)
Description: Physical therapy will be performed using physical agent modality that include hot pack (15 min), and therapeutic exercises (5 repetition per set, 2 sets each session) therapeutic exercises include spinal extension exercise, prone hip extension exercise, posterior pelvic tilt, cat-camel exercise

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Primal Reflex release Technique
Description: The SI/Lumbar release Iliopsoas release Piriformis release Hamstring release Gastrocnemius release
Study: NCT06414707

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vonoprazan, Amoxicillin and Levofloxacin
Description: Group (1) included 160 patients received Vonoprazan 20 mg oral once daily + Levofloxacin 500 mg oral once daily + Amoxicillin 1 gm oral twice daily for 14 days.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pantoprazole 40mg, Amoxicillin and Levofloxacin
Description: Group (2) included 160 patients received Pantoprazole 40 mg oral twice daily + Levofloxacin 500 mg oral once daily + Amoxicillin 1 gm oral twice daily for 14 days.
Study: NCT05179382

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control protocol
Description: I.10 minutes of initial rest in the supine position; II. 90 minutes of treadmill aerobic exercise at an intensity of 60% of the vo2 peak; IV. 60 minutes of passive recovery in the supine position.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hydration protocol
Description: I.10 minutes of initial rest in the supine position; II. 90 minutes of treadmill aerobic exercise at an intensity of 60% of the vo2 peak; IV. 60 minutes of passive recovery in the supine position. V. Water ingestion distributed in 10 equal portions, administered at regular intervals of 15 minutes from the 15th minute of exercise until the end of the recovery period.
Study: NCT05003466

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: SARS-CoV-2 Vaccine (Vero Cells), Inactivated
Description: 2 doses of SARS-CoV-2 Vaccine (Vero Cells), Inactivated with a 28-day interval constitute a primary immunization course. The third dose on 6 months after primary course is the booster dose.~Administer as an intramuscular injection into the lateral deltoid of the upper arm.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 2 doses of Placebo should be administered as an intramuscular injection into the lateral deltoid of the upper arm with a 28-day interval.
Study: NCT05238766

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: DEAL
Description: The DEAL protocol is an Acceptance and Commitment Therapy and Behavioral Activation informed clinical protocol to undermine accommodation and help parents adhere with behavioral treatment plan components.
Study: NCT05675787

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Medroxyprogesterone acetate + Atorvastatin
Description: MPA (at a dosage of 250-500 mg/day,) + Atorvastatin (at a dosage of 20 mg/day), by mouth,
Study: NCT05646134

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Repetitive Transcranial Magnetic Stimulation
Description: Repetitive transcranial magnetic stimulation (rTMS) is a form of non-invasive brain stimulation therapy that modulates brain excitability.
Study: NCT06532786

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fractal Paced
Description: The intervention consists in a metronome-paced strength training session performed 3 times per week (with 48h of rest between sessions), during 4 weeks. Each session consists in 4 sets of 15 repetitions at 65% of the one-repetition maximal (1RM) in single leg extension machine, synchronizing each repetition with fractal external cues presented by a visual metronome. The rest between sets will be set at 2 minutes of rest between sets.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Isochronous Paced
Description: The intervention consists in a metronome-paced strength training session performed 3 times per week (with 48h of rest between sessions), during 4 weeks. Each session consists in 4 sets of 15 repetitions at 65% of the one-repetition maximal (1RM) single in leg extension machine, synchronizing each repetition with isochronus external cues presented by a visual metronome. The rest between sets will be set at 2 minutes of rest between sets.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Self Paced
Description: The intervention consists in a metronome-paced strength training session performed 3 times per week (with 48h of rest between sessions), during 4 weeks. Each session consists in 4 sets of 15 repetitions at 65% of the one-repetition maximal (1RM) in single leg extension machine, at their own self pace (with no metronome). The rest between sets will be set at 2 minutes of rest between sets.
Study: NCT05646134

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Repetitive Transcranial Magnetic Stimulation
Description: Repetitive transcranial magnetic stimulation (rTMS) is a form of non-invasive brain stimulation therapy that modulates brain excitability.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Transcranial Magnetic Stimulation
Description: During Sham Transcranial Magnetic Stimulation the coil will be facing the wall making the stimulation inactive
Study: NCT05951946

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: BR3006-1
Description: All subjects who have been fasting for at least 10 hours prior to administration will take investigational products orally with 150 mL of water at room temperature at around 8 a.m. on the administration day of each period.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BR3006-1
Description: All subjects who have been fasting for at least 10 hours prior to administration will take investigational products orally with 150 mL of water at room temperature at around 8 a.m. on the administration day of each period.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: BR3006-2
Description: All subjects who have been fasting for at least 10 hours prior to administration will take investigational products orally with 150 mL of water at room temperature at around 8 a.m. on the administration day of each period.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BR3006-2
Description: All subjects who have been fasting for at least 10 hours prior to administration will take investigational products orally with 150 mL of water at room temperature at around 8 a.m. on the administration day of each period.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: BR3006-3
Description: All subjects who have been fasting for at least 10 hours prior to administration will take investigational products orally with 150 mL of water at room temperature at around 8 a.m. on the administration day of each period.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BR3006-3
Description: All subjects who have been fasting for at least 10 hours prior to administration will take investigational products orally with 150 mL of water at room temperature at around 8 a.m. on the administration day of each period.
Study: NCT05984706

Intervention type: OTHER
Intervention: Focus groups and Delphi Questionnaire
Description: 1. Focus groups to identify relevant domains of PTSD-related functional impairment in trauma-exposed children and adolescents to ensure content validity. 2. Delphi Questionnaire evaluation of a list of domains of PTSD-related functional impairment in trauma-exposed children and adolescents (previously selected from based on a literature review and focus groups) on a Likert scale of 1 to 5 for their relevance

Intervention type: OTHER
Intervention: Focus groups and Delphi Questionnaire
Description: 1. Focus groups to identify relevant domains of PTSD-related functional impairment in trauma-exposed children and adolescents to ensure content validity. 2. Delphi Questionnaire evaluation of a list of domains of PTSD-related functional impairment in trauma-exposed children and adolescents (previously selected from based on a literature review and focus groups) on a Likert scale of 1 to 5 for their relevance

Intervention type: OTHER
Intervention: Focus groups and Delphi Questionnaire
Description: 1. Focus groups to identify relevant domains of PTSD-related functional impairment in trauma-exposed children and adolescents to ensure content validity. 2. Delphi Questionnaire evaluation of a list of domains of PTSD-related functional impairment in trauma-exposed children and adolescents (previously selected from based on a literature review and focus groups) on a Likert scale of 1 to 5 for their relevance
Study: NCT06378034

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Lactium
Description: 300 mg per day, taken 30 min to 60 min before bedtime

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 300 mg per day, taken 30 min to 60 min before bedtime
Study: NCT06376630

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Esmolol Hcl 10Mg/Ml Inj
Description: the loading dose of 500 mkg/kg for 1 minute, followed by the initial rate of 50 mkg/kg/min. Individual titration depending on the desired hemodynamical effect (to the heart rate of 60 bpm or to the maximum tolerated dose maintaining stable hemodynamics) every 5-15 minutes (the maximum allowed rate of administration is 300 mkg/kg/min) for 6 hours.~Thereafter patients in both treatment arms - the IV esmolol arm and the placebo arm, will be administered oral β-adrenergic blockers, if decided so by the treating physician and unless contraindicated.