Study: NCT04707313

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo (Cohorts 1 and 2)
Description: 4 matching placebo tablets taken twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohorts 1 and 2)
Description: Participants will be randomized to one of 5 active target dose levels (40, 80, 120, 160 or 200 mg BID) achieved through 1-week titration steps, or 3 active target dose levels (120, 160 or 200 mg BID) achieved through 2-week titration steps, taking 4 tablets twice daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo (Cohort 3)
Description: 2 matching placebo tablets taken twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohort 3)
Description: Participants will be randomized to one of 3 active target dose levels (80, 140 or 200 mg BID) achieved through 4-week titration steps, taking 2 tablets twice daily.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohort 3)
Description: Participants will be randomized to one of 3 active target dose levels (80, 140 or 200 mg BID) achieved through 4-week titration steps, taking 2 tablets twice daily.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-06882961 (Cohort 3)
Description: Participants will be randomized to one of 3 active target dose levels (80, 140 or 200 mg BID) achieved through 4-week titration steps, taking 2 tablets twice daily.