TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05198466

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Electrical Stimulation
Description: Subjects will receive an active electrical stimulation device to wear for 1 hour daily for 4 weeks (phase II).

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Electrical Stimulation - Sham
Description: Subjects will receive a sham electrical stimulation device to wear for 1 hour daily for 4 weeks (phase II).
Study: NCT06143241

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Threshold IMT
Description: Threshold is used in respiratory muscle training in the form of resistance loading.
Study: NCT05275257

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Use of Uricap Female, a New Urine Collecting Device
Description: The uridome is changed daily by trained staff
Study: NCT05717634

Intervention type: DIAGNOSTIC_TEST
Intervention: Hysteroscopy
Description: Patients with suspected endometrial pathology, will undergo hysteroscopy with endometrial biopsy or endometrial lesion excision.

Intervention type: DIAGNOSTIC_TEST
Intervention: Hysteroscopy
Description: Patients with suspected endometrial pathology, will undergo hysteroscopy with endometrial biopsy or endometrial lesion excision.

Intervention type: DIAGNOSTIC_TEST
Intervention: Hysteroscopy
Description: Patients with suspected endometrial pathology, will undergo hysteroscopy with endometrial biopsy or endometrial lesion excision.
Study: NCT04994834

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotics
Description: Once a day daily intake of probiotics for at least 28 consecutive starting within 24 hours after birth
Study: NCT05008666

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sintilimab
Description: 1. To evaluate the short-term objective efficacy of sintilimab Sequential combined with chidamide and azacitidine in the treatment of ENKTL-HLH patients.~2. To evaluate the long-term efficacy and safety of sintilimab Sequential combined with chidamide and azacitidine in the treatment of ENKTL-HLH patients.~3. Exploring biomarkers that may have predictive effects.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide
Description: 1. To evaluate the short-term objective efficacy of sintilimab Sequential combined with chidamide and azacitidine in the treatment of ENKTL-HLH patients.~2. To evaluate the long-term efficacy and safety of sintilimab Sequential combined with chidamide and azacitidine in the treatment of ENKTL-HLH patients.~3. Exploring biomarkers that may have predictive effects.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azacitidine
Description: 1. To evaluate the short-term objective efficacy of sintilimab Sequential combined with chidamide and azacitidine in the treatment of ENKTL-HLH patients.~2. To evaluate the long-term efficacy and safety of sintilimab Sequential combined with chidamide and azacitidine in the treatment of ENKTL-HLH patients.~3. Exploring biomarkers that may have predictive effects.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: L-DEP
Description: L-DEP
Study: NCT06010082

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Music Therapy
Description: Music Therapy intervention will be delivered through instructed participants to empty their bladder and then listen to music for 30 min in a semi-fowler's position with their head and shoulders raised 30° in a quiet and dim environment, listening to the music of symphonic music.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Music Therapy
Description: Music Therapy intervention will be delivered through instructed participants to empty their bladder and then listen to music for 30 min in a semi-fowler's position with their head and shoulders raised 30° in a quiet and dim environment, listening to the music of symphonic music.
Study: NCT06143241

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Antiepileptic medication
Description: They will continue their antiepileptic medication prescribed by their doctor.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Antiepileptic medication
Description: They will continue their antiepileptic medication prescribed by their doctor.
Study: NCT05068817

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pilates mat exercises
Description: Pilates mat exercises: Each Pilates session will last for one hour and commence with a 10 minute warm up and finish with a 10 min cool down. The subjects will be taught the 5 key elements of Pilates (lateral costal breathing, centring which is a neutral position of the lumbar spine with activation of the core muscles, ribcage placement, shoulder blade placement and neutral position of the cervical spine with slight upper cervical flexion at the cranio-cervical junction).~Pilates exercise program will consist of warm up exercises, main treatment program (10 level) and cooling down exercises.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: cervical stabilization exercises
Description: training of deep cervical flexor muscles with pressure biofeedback unit, 20 min/day, 3 days/week for 12 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional physiotherapy
Description: 10 min hot pack on cervical area range of motion exercises and isometric neck exercises as a home program 3 days/week for 12 weeks

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional physiotherapy
Description: 10 min hot pack on cervical area range of motion exercises and isometric neck exercises as a home program 3 days/week for 12 weeks

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional physiotherapy
Description: 10 min hot pack on cervical area range of motion exercises and isometric neck exercises as a home program 3 days/week for 12 weeks
Study: NCT04891419

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: JUVÉDERM® VOLUMA® with Lidocaine
Description: JUVÉDERM® VOLUMA® with Lidocaine injectable gel
Study: NCT04659655

Intervention type: PROCEDURE
Group type: OTHER
Intervention: automated annular suturing
Description: RAM® Automated Suturing Technology. The RAM® DEVICE and SEW-EASY® DEVICE are automated suturing devices indicated for use in the approximation of soft tissue and prosthetic materials when used in conjunction with RAM® COR-SUTURE® QUICK LOAD® surgical suture. Devices will be used for the approximation of respective replacement valves during surgical aortic or mitral valve replacement as described in the study protocol. Cases may include use of the RAM® RING/RAM® RACK devices for suture management and the Aortic Root Retractor (ARR) with delivery device.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: automated annular suturing
Description: RAM® Automated Suturing Technology. The RAM® DEVICE and SEW-EASY® DEVICE are automated suturing devices indicated for use in the approximation of soft tissue and prosthetic materials when used in conjunction with RAM® COR-SUTURE® QUICK LOAD® surgical suture. Devices will be used for the approximation of respective replacement valves during surgical aortic or mitral valve replacement as described in the study protocol. Cases may include use of the RAM® RING/RAM® RACK devices for suture management and the Aortic Root Retractor (ARR) with delivery device.
Study: NCT05208138

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Senhance Surgical System from Asensus
Description: Bariatric operation with the Senhance Surgical System
Study: NCT04929769

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Total Laparoscopic or Robotic Radical Hysterectomy
Description: Radical hysterectomy with bilateral pelvic lymph node dissection is performed as standard type C RH by Q-M classification, including cardinal ligaments divided at pelvic sidewall and uterosacral ligaments divided at near the sacral origin and the upper 1/4 to 1/3 of the vagina.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Total Abdominal Radical Hysterectomy
Description: Radical hysterectomy with bilateral pelvic lymph node dissection is performed as standard type C RH by Q-M classification, including cardinal ligaments divided at pelvic sidewall and uterosacral ligaments divided at near the sacral origin and the upper 1/4 to 1/3 of the vagina.
Study: NCT05979909

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mitomycin C
Description: Mitomycin (40 mg in 40 mL of sterile water) will be administered through a Foley catheter, which will be clamped for two hours.
Study: NCT05579418

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Evolocumab
Description: Evolocumab is an injection for management of dyslipidemia
Study: NCT05449834

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fibrinogen Concentrate
Description: 3g Fibrinogen Concentrate

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Cryoprecipitate
Description: 10U WB or 4U Apheresis Cryoprecipitate
Study: NCT01229540

Intervention type: GENETIC
Group type: NO_INTERVENTION
Intervention: genetic analyzer
Study: NCT05982457

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: virtual reality group
Description: Before the training, the Descriptive Information Form and the State and Trait Anxiety Inventory as a pre-test will be applied by face interview method. They will study for two hours. After the introduction and information, the lens and pupil distances of the virtual reality Glasses will be adjusted according to each student and students are expected to wear their vision. The application is the same for every student. Students will be introduced through the images projected to the computer simultaneously while in the application. Cervical dilation and effacement application will be monitored using virtual reality glasses. Next, the students will be asked to touch the woman's perineum with their hands to make her image transparent and we ask them to watch the cervix structures again. After the application, Learning Satisfaction and Self-Confidence in Learning Scale and State and Trait Anxiety Inventory will be applied as a post-test.
Study: NCT06435286

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Proflavine Hemisulfate
Description: Approximately 5-10 ml of proflavine hemisulfate (0.01%) will be sprayed on the esophageal mucosa.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Artificial Intelligence Mobile High-Resolution Microendoscope
Description: The AI-mHRME will be inserted through the endoscope biopsy channel and gently placed against the mucosa where proflavine was sprayed. The probe will transmit images to the computer/laptop for the clinician to observe any abnormal tissues and save photos of these tissues.
Study: NCT06264531

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Bevacizumab 5 mg/kg as a slow infusion over 90 minutes every 14 days for a total of 6 injections

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: NaCl 0.9% slow infusion over 90 minutes every 14 days for a total of 6 injections
Study: NCT05318287

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Walk with Me
Description: Walk with Me is a perinatal grief mobile application to provide supportive care to bereaved parents. The application includes modules to guide bereaved parents through strategies to help support them through their grieving.
Study: NCT04648150

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Evaluation of a millimeter wave emission bracelet for improving Parkinson's disease symptoms
Description: Evaluation of a millimeter wave emission bracelet -type medical device for improving Parkinson's disease symptoms: multicenter, double-blind randomized controlled trial

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Evaluation of a millimeter wave emission bracelet for improving Parkinson's disease symptoms
Description: Evaluation of a millimeter wave emission bracelet -type medical device for improving Parkinson's disease symptoms: multicenter, double-blind randomized controlled trial
Study: NCT06670664

Intervention type: OTHER
Intervention: No intervention
Description: No intervention. This is a single-group study.
Study: NCT06603220

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oral EVO756
Description: Oral EVO756, once daily
Study: NCT06681987

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: simulation training
Description: One group of students will practice computer-based simulation for pre-eclampsia and eclampsia case management skills using a high-fidelity simulator (n = 15) (subgroups n=3), while the other group will practice with a low-fidelity model (n = 15; subgroups n=3). In the first stage, the case will be written for the high-fidelity simulator and will be submitted to the opinions of experts in the field. After the necessary arrangements are made, the groups will be randomized and allocated. In the second stage, the experimental group will be presented with a virtual reality simulator, and the control group will be presented with a case example of preeclampsia and eclampsia with a low-level simulator. In order to evaluate and increase the teamwork skills of the students in the experimental and control groups, the students will be divided into subgroups of three.
Study: NCT06719505

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: ME
Description: Exercises selected with a focus on the major muscle groups. There will be one protocol for the first 3 months and a second protocol for months 4-6, with the number of repetitions for each exercise varying from 3 sets of 8 to 10 repetitions, totaling 18 exercises.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PE
Description: The stretching and strengthening exercises will target the major muscle groups, and at the end of each session (lasting approximately 60 minutes), the instructor will guide the participant through a relaxation exercise using an EVA foam roller. The exercises were selected to improve overall muscle strength, as traditionally applied in Pilates. There will be one protocol for the first 3 months and a second protocol for months 4-6, with 17 exercises in each protocol, varying from 3 sets of 8 to 10 repetitions.
Study: NCT06711510

Intervention type: OTHER
Group type: OTHER
Intervention: Clinical, behavioral and cognitive evaluation
Description: Questionnaries and tests

Intervention type: OTHER
Group type: OTHER
Intervention: blood sampling
Description: blood sampling (56ml max)

Intervention type: OTHER
Group type: OTHER
Intervention: brain MRI
Description: brain MRI (35 to 70 minutes)

Intervention type: OTHER
Group type: OTHER
Intervention: olfactory swab sampling with nasal brush
Description: olfactory swab sampling with nasal brush

Intervention type: OTHER
Group type: OTHER
Intervention: skin punch biopsy
Description: skin punch biopsy (optional intervention)

Intervention type: OTHER
Group type: OTHER
Intervention: lumbar puncture for CSF sampling
Description: lumbar puncture for CSF sampling (optional intervention)
Study: NCT06723951

Intervention type: OTHER
Intervention: QUALAS survey
Description: Participants will be asked to complete the surveys at one (controls) and two (patients) timepoints.

Intervention type: OTHER
Intervention: QUALAS survey
Description: Participants will be asked to complete the surveys at one (controls) and two (patients) timepoints.

Intervention type: OTHER
Intervention: QUALAS survey
Description: Participants will be asked to complete the surveys at one (controls) and two (patients) timepoints.

Intervention type: OTHER
Intervention: QUALAS survey
Description: Participants will be asked to complete the surveys at one (controls) and two (patients) timepoints.

Intervention type: OTHER
Intervention: QUALAS survey
Description: Participants will be asked to complete the surveys at one (controls) and two (patients) timepoints.

Intervention type: OTHER
Intervention: QUALAS survey
Description: Participants will be asked to complete the surveys at one (controls) and two (patients) timepoints.
Study: NCT06722976

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multicomponent exercise programs
Description: The program is organized into three phases: (1) Initial assessment; (2) Multicomponent training sessions; (3) Final assessment.~1. The initial assessment will consist of physical fitness tests (lasting around 1 hour) and Neuropsychological Assessment tests (lasting around 1.5 hours).~2. The multicomponent training sessions will last 3 months, twice a week, 50 minutes each session.~3. The final assessment will be the same as the initial assessment (physical fitness tests (about 1 hour) and Neuropsychological Assessment tests (about 1.5 hours).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multicomponent exercise programs
Description: The program is organized into three phases: (1) Initial assessment; (2) Multicomponent training sessions; (3) Final assessment.~1. The initial assessment will consist of physical fitness tests (lasting around 1 hour) and Neuropsychological Assessment tests (lasting around 1.5 hours).~2. The multicomponent training sessions will last 3 months, twice a week, 50 minutes each session.~3. The final assessment will be the same as the initial assessment (physical fitness tests (about 1 hour) and Neuropsychological Assessment tests (about 1.5 hours).
Study: NCT06723912

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Health Action Process Approach-Based Program
Description: Health Action Process Approach-Based Program: The program is planned for six weeks (six sessions). Sessions will be held once a week for 30-45 minutes. Within the scope of the program, care - structured nursing care plans based on the Health Action Process Approach will be made -, education and counseling will be provided. Sessions will be held in a quiet, calm environment in the hospital, and if such an environment cannot be provided, they will be held at the patient's home. The day, time and place of the sessions will be decided together with the participant after each interview or session. At the beginning of each session, the previous session will be briefly recalled and the homework (SWOT analysis, treatment adherence tracking chart or SMART goal plan) given in the previous session will be evaluated. At the end of each session, the evaluation of that day's session will be carried out briefly.
Study: NCT06733779

Intervention type: OTHER
Intervention: observation
Description: cross-sectional study

Intervention type: OTHER
Intervention: observation
Description: cross-sectional study

Intervention type: OTHER
Intervention: observation
Description: cross-sectional study
Study: NCT06724276

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: balloon angioplasty and stenting of lower extremity vessels + fibroblasts
Description: A balloon or a stent of the required size (according to the intrinsic diameter of the affected vessel) is delivered to the affected area, sequential balloon dilatation with exposure of up to 5 minutes or stenting of the vessel is performed. After completion, control angiography is performed with evaluation of the result. Instruments, introdjuncer are removed. Manual compression haemostasis (up to 20 minutes over the puncture site) followed by aseptic pressure dressing on the puncture site for 12 hours with bed rest. After surgery, fibroblasts will be applied to the wound for 24 hours.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: balloon angioplasty and stenting of lower extremity vessels
Description: A balloon or a stent of the required size (according to the intrinsic diameter of the affected vessel) is delivered to the affected area, sequential balloon dilatation with exposure of up to 5 minutes or stenting of the vessel is performed. After completion, control angiography is performed with evaluation of the result. Instruments, introdjuncer are removed. Manual compression haemostasis (up to 20 minutes over the puncture site) followed by aseptic pressure dressing on the puncture site for 12 hours with bed rest.
Study: NCT06731946

Intervention type: DEVICE
Intervention: Flow diverting
Description: Flow diverter has become the standardized treatment method for Intracranial aneurysms (IAs), which is different from angioplasty, coiling, etc.
Study: NCT06732908

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: LipoMicel Berberine
Description: Berberine powder in a LipoMicel matrix encapsulated in soft gel.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: microcrystalline cellulose
Study: NCT06724965

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Trans STAIR
Description: Skills Training in Affect and Interpersonal Regulation (STAIR) is a transdiagnostic evidenced-based mental health treatment for individuals who have experienced multiple traumas. STAIR is based in cognitive-behavioral principles and delivered in a flexible manner over 8 group sessions, with demonstrated efficacy for the treatment of PTSD and other mental health symptoms. This trial will adapt and pilot test the STAIR intervention to be culturally appropriate and acceptable for TGD persons, adding content related to TGD health and wellness, coping with minority stress, responding to stigma and microaggressions, social support, and community connectedness, self-compassion, celebrating trans joy, trans advocacy, sexual health and PrEP use.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: PrEP Well
Description: This pilot trial will leverage PrEP Well, a multi-level implementation strategy for providing PrEP in TGD-serving contexts by integrating peer-led PrEP navigation with programming that addresses other social and structural needs of the TGD community (e.g., housing, legal, employment, gender-affirmation, primary care)

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PrEP Well
Description: This pilot trial will leverage PrEP Well, a multi-level implementation strategy for providing PrEP in TGD-serving contexts by integrating peer-led PrEP navigation with programming that addresses other social and structural needs of the TGD community (e.g., housing, legal, employment, gender-affirmation, primary care)
Study: NCT06732999

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Gaze-Contingent Music Reward Therapy (GC-MRT
Description: Gaze-Contingent Music Reward Therapy (GC-MRT) is a treatment method for adults with social anxiety disorder found to be effective in reducing social anxiety in various RCTs. This method includes a computerized cognitive training to redirect threat-related attention patterns.
Study: NCT06731933

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: BVEC
Description: The study drug will be administered by home nurse at Subjects home for the participants residing in US. No drug will be applied when at study site. The subjects enrolled in Bari, Italy will not be administered BVEC.