Study: NCT05398757

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Mini mental state exame (MMSE)
Description: Before the operation, and on the 1st, 3rd and 5th day after the operation, the Mini mental state exam (MMSE) score will be measured

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Mini mental state exame (MMSE)
Description: Before the operation, and on the 1st, 3rd and 5th day after the operation, the Mini mental state exam (MMSE) score will be measured

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Mini mental state exame (MMSE)
Description: Before the operation, and on the 1st, 3rd and 5th day after the operation, the Mini mental state exam (MMSE) score will be measured

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Digit Symbol Substitution Test (DSST)
Description: Before the operation, and on the 1st, 3rd and 5th day after the operation, the Digit Symbol Substitution Test (DSST) score will be measured

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Digit Symbol Substitution Test (DSST)
Description: Before the operation, and on the 1st, 3rd and 5th day after the operation, the Digit Symbol Substitution Test (DSST) score will be measured

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Digit Symbol Substitution Test (DSST)
Description: Before the operation, and on the 1st, 3rd and 5th day after the operation, the Digit Symbol Substitution Test (DSST) score will be measured

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Numeric rating Scale (NRS)
Description: 4h, 8h, 12h and 24h after surgery, pain in all patients will be assessed by the NRS scale.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Numeric rating Scale (NRS)
Description: 4h, 8h, 12h and 24h after surgery, pain in all patients will be assessed by the NRS scale.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Numeric rating Scale (NRS)
Description: 4h, 8h, 12h and 24h after surgery, pain in all patients will be assessed by the NRS scale.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Postoperative inflammation
Description: All patients included in the study will have their blood taken for laboratory analysis of red blood cells, leukocytes, CRP, PCT, ChE and IL-6. Analyzes will be performed before the procedure, on the 1st, 3rd and 5th postoperative day.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Postoperative inflammation
Description: All patients included in the study will have their blood taken for laboratory analysis of red blood cells, leukocytes, CRP, PCT, ChE and IL-6. Analyzes will be performed before the procedure, on the 1st, 3rd and 5th postoperative day.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Postoperative inflammation
Description: All patients included in the study will have their blood taken for laboratory analysis of red blood cells, leukocytes, CRP, PCT, ChE and IL-6. Analyzes will be performed before the procedure, on the 1st, 3rd and 5th postoperative day.

Intervention type: DRUG
Group type: OTHER
Intervention: Midazolam
Description: For sedation during surgery, patients in midazolam group will receive i.v. midazolam in dose 0.05 - 0.07 mg/kg after spinal anesthesia.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol
Description: For sedation during surgery, patients in propofol group will receive i.v. propofol in dose 25-27 mcg/kg/min.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexmedetomidin
Description: For sedation during surgery, patients in dexmedetomidin gropu will receive i.v. dexmedetomidin in dose 0.5 mcg/kg/h