Study: NCT05553184

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Formoterol Fumarate 12 micrograms Inhalation Powder
Description: At time 60 minutes, a total of 48 micrograms will be inhaled within 3 minutes: 4 inhalations of 12 micrograms of fumarate formoterol (Oxeze® Turbuhaler®).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Formoterol Fumarate 12 micrograms Inhalation Powder
Description: At time 60 minutes, a total of 48 micrograms will be inhaled within 3 minutes: 4 inhalations of 12 micrograms of fumarate formoterol (Oxeze® Turbuhaler®).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nicotinic Acid 50 MG Oral Tablet
Description: a total dose of 1050 MG will be ingested. From time 0 to 180 minutes, doses of 150 MG will be repeated every 30 minutes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Acute Cold Exposure
Description: Participants will be fitted with a liquid-conditioned tube suit. The liquid-conditioned tube suit will be perfused with 18°C water using a temperature- and flow-controlled circulation bath from time 0 to 180 min.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Positron Emission Tomography (PET)
Description: PET imaging using C11-palmitate (time 90), C11-acetate (time 120) and F18-Fluorodeoxyglucose (FDG) (time 150)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography (PET)
Description: PET imaging using C11-palmitate (time 90), C11-acetate (time 120) and F18-Fluorodeoxyglucose (FDG) (time 150)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Positron Emission Tomography (PET)
Description: PET imaging using C11-palmitate (time 90), C11-acetate (time 120) and F18-Fluorodeoxyglucose (FDG) (time 150)

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Indirect calorimetry
Description: will be repeated every hour, for 20 minutes, using Vmax29n.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Indirect calorimetry
Description: will be repeated every hour, for 20 minutes, using Vmax29n.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Indirect calorimetry
Description: will be repeated every hour, for 20 minutes, using Vmax29n.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: dual-energy x-ray absorptiometry (DEXA scan)
Description: Whole body scan

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Biopsy
Description: After local anesthesia with 2% xylocaine without epinephrine, 100-200 mg of subcutaneous adipose tissue will be sampled by needle (14G) biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: After local anesthesia with 2% xylocaine without epinephrine, 100-200 mg of subcutaneous adipose tissue will be sampled by needle (14G) biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy
Description: After local anesthesia with 2% xylocaine without epinephrine, 100-200 mg of subcutaneous adipose tissue will be sampled by needle (14G) biopsy

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: iv lines
Description: for stable tracer perfusion and blood sampling

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: iv lines
Description: for stable tracer perfusion and blood sampling

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: iv lines
Description: for stable tracer perfusion and blood sampling

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Electromyogram (EMG)
Description: Surface electrodes will be used to measure skeletal muscle activity and shivering intensity