TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05273229

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Gait
Description: Virtual Gait: the patient will be placed in a standing position (with an ad-hoc designed help system) in front of a mirror (from the waist up) and a screen (from the waist down) where a video of legs walking on a treadmill will be projected and overcoming obstacles. Projected legs will be customized based on height, using the tibia length method.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Gait
Description: Virtual Gait: the patient will be placed in a standing position (with an ad-hoc designed help system) in front of a mirror (from the waist up) and a screen (from the waist down) where a video of legs walking on a treadmill will be projected and overcoming obstacles. Projected legs will be customized based on height, using the tibia length method.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Physical exercise
Description: PE: it will be divided into two parts: in the first one, a gait technique training will be carried out and, in the second, a leg strength training, for 30 min. Exercises:~* Coordination exercises: normal and lateral parallel walking and walking with obstacles.~* Functional exercises such as climbing stairs, etc.~* Lower limb strength exercises. Strength exercises will be prescribed according to the guidelines of the American College of Sports Medicine (ACSM). Progression will be customized based on individual abilities.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical exercise
Description: PE: it will be divided into two parts: in the first one, a gait technique training will be carried out and, in the second, a leg strength training, for 30 min. Exercises:~* Coordination exercises: normal and lateral parallel walking and walking with obstacles.~* Functional exercises such as climbing stairs, etc.~* Lower limb strength exercises. Strength exercises will be prescribed according to the guidelines of the American College of Sports Medicine (ACSM). Progression will be customized based on individual abilities.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham Virtual Gait
Description: only the placebo virtual gait.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham Virtual Gait
Description: only the placebo virtual gait.
Study: NCT05271097

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: MyLink2Care app full functionality
Description: Participants will be shown how to download the app and use the assessment tool.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: MyLink2Care app major intervention features inactivated
Description: Participants will be shown how to download the app and use the assessment tool.
Study: NCT05247242

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lakeshore Online Fitness (Online)
Description: Online physical activity program delivered to residents of Tarrant, AL via teleconferencing technology to a local community center. Instructors from Lakeshore will lead the physical activity program. This intervention will last six weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lakeshore Online Fitness (Online)
Description: Online physical activity program delivered to residents of Tarrant, AL via teleconferencing technology to a local community center. Instructors from Lakeshore will lead the physical activity program. This intervention will last six weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Get Active with Virtual Reality (VR)
Description: Participants will utilize the Oculus Quest 2 virtual reality headset, which is a head-mounted display system where users can interact with a virtual environment in a gaming setting. The Oculus Quest 2 incorporates social features where participants can interact with other users. This VR intervention will include periods of gameplay where participants can play games in either competitive or cooperative settings. This intervention will last six weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Get Active with Virtual Reality (VR)
Description: Participants will utilize the Oculus Quest 2 virtual reality headset, which is a head-mounted display system where users can interact with a virtual environment in a gaming setting. The Oculus Quest 2 incorporates social features where participants can interact with other users. This VR intervention will include periods of gameplay where participants can play games in either competitive or cooperative settings. This intervention will last six weeks.
Study: NCT06787339

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Capecitabine
Description: Capecitabine 650mg/m2, bid, p.o for 1 year
Study: NCT06786286

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [14C]-ITI-1284
Description: \[14C\]-ITI-1284 20 mg oral solution (not more than 22 μCi), subcutaneous administration
Study: NCT06784635

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: In person
Description: Participant dyads will meet in person for a mock clinical interview, seated at a desk opposite their counterpart. They will be in an office setting. There will be a sham white noise and lamp device placed on the desk.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online interaction
Description: Participant dyads will meet online in a mock clinical interview, via an encrypted video call, seated at a desk. They will be in an office setting. There will be a sham white noise and lamp device placed on the desk.
Study: NCT06785324

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nutrition Intervention
Description: The nutrition intervention will target a 10% caloric deficit calculated from each patient's Basal Metabolic Rate (WHO/Schofield) utilizing a high protein (\>25%), low fat (\<25%), low glycemic index/high fiber (45-55%) diet.~The study registered dietician (RD) will meet with the patient on day of enrollment to go over the menu of dietary options and will re-assess the patient every two days (excluding weekends) for adherence.~My Plate (USDA) will control portion size and eating habits.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise intervention
Description: The exercise intervention will target 200 minutes of moderate physical activity weekly, as defined by Metabolic Equivalents (METs) of 3-6, made up of aerobic and resistance training activities tailored to the patient's preference by working with the study physical therapist (PT).~Physical Therapist to evaluate patient every 48 hours, excluding weekends.
Study: NCT06783634

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: Group 2 (dexamethasone group) single intra venous high dose of dexamethasone 1mg/kg with maximum dose of 100 mg.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Group 1 (Control group) will receive normal saline as a placebo.
Study: NCT06784518

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinical scores and functional MRI
Description: Motor evoked potentials between Day 3-Day 7 of the stroke, for a equal distribution of patients into three prognostic groups according to the PREP2 algorithm (good, limited and poor). Longitudinal follow-up with clinical scores and functional MRI at Day 7-Day 10, Day 30, Month 3 and Month 6 of stroke.
Study: NCT06788002

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low-dose radiotherapy combine with chemoimmunotherapy
Description: Radiation: 1.4Gy for 5 days to the liver metastasis before chemoimmunotherapy. Chemoimmunotherapy: gemcitabine(1000mg per square meter on days 1,8) , cisplatin (80mg per square meter on day 1), penpulimab (200mg, day1)
Study: NCT06782984

Intervention type: OTHER
Intervention: Organoid-based drug sensitivity test
Description: The intervention in this study involves utilizing glioblastoma organoids (GBOs) to perform an organoid-based drug sensitivity test (DST) and retrospectively comparing the results with clinical outcomes. Notably, no interventions will be applied to participants based on GBO-DST results; the study is limited to retrospective analysis.~The GBO-DST is conducted by performing a drug response assay with temozolomide to determine the half-maximal inhibitory concentration (IC50), which serves to classify GBOs as TMZ-sensitive or TMZ-resistant. This classification is further validated through GBO cell survival analysis.
Study: NCT06011954

Intervention type: DRUG
Intervention: Enfortumab Vedotin
Description: Intravenous
Study: NCT05561738

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nicotinamide Riboside Chloride
Description: The intervention consists of 6 months to 1 year of daily oral therapy with Nicotinamide Riboside Chloride (Niagen) in addition to standard therapy.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Placebo
Description: The intervention consists of 6 months to 1 year of daily oral therapy with placebo (Maltodextran capsules of similar size, shape and color as Niagen) in addition to standard therapy.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard of Care
Description: Standard of Care

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard of Care
Description: Standard of Care
Study: NCT04077749

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Femdophilus probiotic
Description: Lactobacillus rhamnosus (GR-1®) and reuteri (RC-14®) species, which is offered as an over the counter probiotic capsule sold under the brand name of Femdophilus dissolved in 50 mL normal saline at room temperature.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Normal Saline
Description: 50 mL normal saline at room temperature
Study: NCT06414772

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Use of MARTI application in addition with a classical consultation/support
Description: Participants will use MARTI in order to establish the medical history during their waiting time.
Study: NCT05592002

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Genio System
Description: The Genio® IS electrode placement does not require an extensive surgical manipulation of the hypoglossal nerve, it requires only a single incision site and does not require battery replacements as those are external components. Whereas UPPP surgery and other similar upper airway enlargement surgeries are much more extensive, are irreversible and tend to have more complications and modest long-term results in reducing OSA severity and symptoms. In summary, the solution offered by the Genio System to treat OSA patients with CCC using bilateral HGNS has a favorable risk-benefit ratio, as demonstrated by evidence from 2 studies.
Study: NCT04985578

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dry needling
Description: The therapist will located the TrP that refers the most pain and will apply manual compression until the participant will reported pain. After that, dry needling technique will be performed on the TrP for 60 seconds.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Sham dry needling
Description: The therapist will located the TrP that refers the most pain and will apply manual compression until the participant will reported pain. After that, dry needling technique will be performed on the TrP for 60 seconds with a sham needle without tip.
Study: NCT06785285

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexmedetomidine
Description: To compare the effects of fentanyl and dexmedetomidine when used as adjuvants to intrathecal bupivacaine in elective cesarean section, assessing their impact on the onset and duration of spinal anesthesia, quality of analgesia, hemodynamic stability, incidence of side effects, and neonatal outcomes

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexmedetomidine
Description: To compare the effects of fentanyl and dexmedetomidine when used as adjuvants to intrathecal bupivacaine in elective cesarean section, assessing their impact on the onset and duration of spinal anesthesia, quality of analgesia, hemodynamic stability, incidence of side effects, and neonatal outcomes
Study: NCT06785402

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ceftriaxone treatment
Description: 9 infusions spaced out approximately every 5 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: D5W (placebo)
Study: NCT06786702

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Laparoscopic TAPP (Trans Abdominal Pre-Peritoneal) hernia repair: Round Ligament Preservation
Description: Group 1 (Round Ligament Preservation): Patients will undergo laparoscopic TAPP surgery with the round ligament preserved. The preservation will be achieved using a longitudinal incision technique in the peritoneum.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Laparoscopic TAPP (Trans Abdominal Pre-Peritoneal) hernia repair: Round Ligament Cutting
Description: Group 2 (Round Ligament Cutting): Patients will undergo laparoscopic TAPP surgery with the round ligament cut close to the peritoneum using an energy device.
Study: NCT06785688

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Protective gear irradiated by infrared rays
Description: irradiated by infrared rays back brace

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Protective gear irradiated by infrared rays
Description: irradiated by infrared rays back brace
Study: NCT06788093

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ED Clinical Decision Support (CDS-ED)
Description: The ED-CDS intervention is designed as a discrete decision support aid to influence initial antibiotic decision-making in the ED. This intervention will feature a clinician-facing LRTI dashboard for end-users that assimilates relevant clinical data (e.g., vital signs, select diagnostic tests, links to reference information) and offers tailored suggestions for antibiotic initiation, related diagnostic testing, and in those receiving antibiotics, preferred options and alternatives for antibiotic choice, route, dose, and duration.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Transitions Clinical Decision Support (CDS-Tr)
Description: The CDS-Tr intervention is designed as a longitudinal decision support aid to influence initial and ongoing (i.e., continuation, discontinuation, escalation, or de-escalation) antibiotic decision-making in the hospital setting. This intervention will also feature the LRTI dashboard along with additional tailored suggestions and recommendations for antibiotic decision-making upon hospital admission, and for those receiving antibiotics, at the time of discharge. Additionally, CDS-Tr will be active at the time of any service transition (i.e., hospital to intensive care or vice versa) and at pre-specified time points (e.g., approximately 48 hours and 120 hours following ED triage for encounters remaining in the hospital).
Study: NCT06786793

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Computer-aided detection (CADe)
Description: Endo-Aid CADe system is an AI-assisted computer-aided lesion detection application on ENDO-AID hardware. It uses a complex algorithm created via a neural network developed and taught by Olympus. With this new app, the sophisticated machine learning system can alert the endoscopist in real-time when a suspicious lesion appears on the screen. The image from the vision processor is transferred to the CADe device. The computer application recognizes the shape of the polyps and marks their place on the monitor screen.
Study: NCT06786273

Intervention type: GENETIC
Group type: OTHER
Intervention: Small RNA sequencing
Description: The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.

Intervention type: GENETIC
Group type: OTHER
Intervention: Small RNA sequencing
Description: The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.

Intervention type: GENETIC
Group type: OTHER
Intervention: Small RNA sequencing
Description: The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.

Intervention type: GENETIC
Group type: OTHER
Intervention: Small RNA sequencing
Description: The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.

Intervention type: GENETIC
Group type: OTHER
Intervention: Small RNA sequencing
Description: The blood and endometrial tissue samples collected from the study groups will undergo small RNA sequencing to investigate the microRNA expression profiles associated with that phase.
Study: NCT06783140

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nab paclitaxel
Description: Paclitaxel Powder For Injectable Suspension Nanoparticle, Albumin-bound Paclitaxel is an albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nab paclitaxel
Description: Paclitaxel Powder For Injectable Suspension Nanoparticle, Albumin-bound Paclitaxel is an albumin-stabilized nanoparticle formulation of the natural taxane paclitaxel with antineoplastic activity.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemcitabine
Description: Gemcitabine is a hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Gemcitabine
Description: Gemcitabine is a hydrochloride salt of an analogue of the antimetabolite nucleoside deoxycytidine with antineoplastic activity.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Cisplatin is an alkylating-like inorganic platinum agent (cis-diamminedichloroplatinum) with antineoplastic activity.
Study: NCT06784908

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Yale Pain Stress Task (YPST)
Description: Individuals in the experimental cohort will be scheduled for 2 experimental sessions 1-3 days apart. The YPST stress experiment includes a stress and no-stress session (order randomly assigned, counter-balanced across subjects), and involves multiple (up to 3) unpredictable number of consecutive 3-minute trials of ice-bath (stress) or warm-bath (no stress) forearm immersion (stress) with subjective, physiologic endocrine and immune assessments repeated at specified time points.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Yale Pain Stress Task (YPST)
Description: Individuals in the experimental cohort will be scheduled for 2 experimental sessions 1-3 days apart. The YPST stress experiment includes a stress and no-stress session (order randomly assigned, counter-balanced across subjects), and involves multiple (up to 3) unpredictable number of consecutive 3-minute trials of ice-bath (stress) or warm-bath (no stress) forearm immersion (stress) with subjective, physiologic endocrine and immune assessments repeated at specified time points.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Yale Pain Stress Task (YPST)
Description: Individuals in the experimental cohort will be scheduled for 2 experimental sessions 1-3 days apart. The YPST stress experiment includes a stress and no-stress session (order randomly assigned, counter-balanced across subjects), and involves multiple (up to 3) unpredictable number of consecutive 3-minute trials of ice-bath (stress) or warm-bath (no stress) forearm immersion (stress) with subjective, physiologic endocrine and immune assessments repeated at specified time points.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Yale Pain Stress Task (YPST)
Description: Individuals in the experimental cohort will be scheduled for 2 experimental sessions 1-3 days apart. The YPST stress experiment includes a stress and no-stress session (order randomly assigned, counter-balanced across subjects), and involves multiple (up to 3) unpredictable number of consecutive 3-minute trials of ice-bath (stress) or warm-bath (no stress) forearm immersion (stress) with subjective, physiologic endocrine and immune assessments repeated at specified time points.
Study: NCT06783920

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: music
Description: music will be played during the copper IUD insertion

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: no music
Description: IUD insertion will be done as usual without music
Study: NCT06787521

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: evidence-based labor guide
Description: Participants will be provided with written education about potential complications and interventions. Information will be provided at the time of admission for labor induction.
Study: NCT06782581

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Contribution to Caregivers Well-Being
Description: Contribute to caregiver's well-being via household tasks.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Control
Description: factually describe either (1) immediate environment, (2) the weather, or (3) organization of closet
Study: NCT06784440

Intervention type: GENETIC
Group type: OTHER
Intervention: Evaluation of circulating donor free DNA in the recipient's blood (Dd-cfDNA: donor-derived cell free DNA)
Description: From the blood samples taken, 2 mL of plasma separated from blood will be stored in EDTA frozen at -80°C. This material will later be processed by NGS run using of CareDX kits. The result will be provided by dedicated software as percentage of donor DNA in relation to recipient DNA.
Study: NCT06779201

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fasting
Description: One-week fasting without limit of water drink (Participants can feel free to drink water )
Study: NCT06787976

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dolutegravir (DTG)
Description: Dolutegravir + Tenofovir Disoproxil Fumarate / Emtricitabine

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Darunavir/Cobicistat (FDC)
Description: Darunavir Cobicistat + TDF/FTC
Study: NCT06784791

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amivantamab Intravenous
Description: Stage 1: Pre-operative amivantamab monotherapy Stage 2: Pre-operative amivantamab treatment plus chemotherapy (carboplatin/pemetrexed)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amivantamab Intravenous
Description: Stage 1: Pre-operative amivantamab monotherapy Stage 2: Pre-operative amivantamab treatment plus chemotherapy (carboplatin/pemetrexed)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin/Pemetrexed
Description: Stage 2: Pre-operative amivantamab plus chemotherapy (carboplatin/pemetrexed)
Study: NCT06786182

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PFM Educational Program
Description: A structured telematic educational program covering PFM anatomy, function, and proper activation techniques. Content includes videos, visual guides, and exercises aimed at promoting PFM co-contraction and awareness.