TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05739448

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: nutritional intervention
Description: The nutritional intervention will be based on the following 4 elements: nutritional follow-up by a dietician, fortified meals, tender and juicy meat dishes and fish dishes

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: nutritional intervention
Description: The nutritional intervention will be based on the following 4 elements: nutritional follow-up by a dietician, fortified meals, tender and juicy meat dishes and fish dishes

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: physical activity
Description: The physical activity intervention will be based on the following 2 elements: Follow-up with a trainer for adapted exercise and physical exercise instruction sheets
Study: NCT04825184

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Body image chatbot
Description: See arm/group description.
Study: NCT06024369

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: CPM Device
Description: Wearable monitor used for 5 minutes per day.
Study: NCT05496907

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Diabetes specialist nurse-led collaborative care intervention
Description: 10 sessions with a diabetes nurse to help improve physical and mental health outcomes
Study: NCT06513806

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Granisetron 1 Mg/mL Intravenous Solution
Description: will receive granisetron 3 mg iv bolus

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pethidin
Description: will receive pethidine 25 mg iv bolus
Study: NCT05576623

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AdCLD-CoV19-1 OMI (Part A)
Description: 20 participants will receive investigational product (AdCLD-CoV19-1 OMI) via intramuscular injection in the deltoid muscle

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AdCLD-CoV19-1 OMI (Part B)
Description: 250 participants will receive investigational product (AdCLD-CoV19-1 OMI) via intramuscular injection in the deltoid muscle

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo (Part B)
Description: 50 participants will receive placebo via intramuscular injection in the deltoid muscle
Study: NCT04595266

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: FOLFOX regimen
Description: Leucovorin: 400 mg / m2 IV over 15 minutes on day 1 of each cycle. Fluorouracil (5-FU): 400mg / m2 IV bolus (15 min) followed by continuous IV infusion for 46 h of 2,400 mg / m2 on day 1 of each cycle.~Oxaliplatin 85 mg / m2 IV over 120 minutes on cycle day 1

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FOLFOX regimen
Description: Leucovorin: 400 mg / m2 IV over 15 minutes on day 1 of each cycle. Fluorouracil (5-FU): 400mg / m2 IV bolus (15 min) followed by continuous IV infusion for 46 h of 2,400 mg / m2 on day 1 of each cycle.~Oxaliplatin 85 mg / m2 IV over 120 minutes on cycle day 1

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Anti-EGFR or Bevacizumab
Description: In case of RAS wt colorectal cancer administer anti-EGFR together with FOLFOX6m, and in case of mutated RAS colorectal cancer administer Bevacizumab together with FOLFOX6m.~Treatment administered following Summary of medicinal Product Characteristics (SmPC) approved indications.
Study: NCT05271188

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Infiltration of local anaesthetic between popliteal artery and posterior knee capsule
Description: Adductor canal block (ACB) is a popular peripheral nerve block that has been shown to decrease pain significantly and thereby opioid consumption with minimal effect on quadriceps function \[8\]. Though ACB provides analgesia to the peripatellar and intra-articular aspect of knee joint, it does not relieve posterior knee pain which is moderate to severe in intensity \[9, 10\]. The recent technique of an ultrasound (US)-guided local anesthetic infiltration of the interspace between popliteal artery and the capsule of posterior knee (IPACK) has shown to provide significant posterior knee analgesia without affecting the common peroneal nerve (CPN) \[11\]. We postulated that IPACK will provide better pain relief and improve knee function in the immediate postoperative period compared to ACB

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Infiltration of local anaesthetic between popliteal artery and posterior knee capsule
Description: Adductor canal block (ACB) is a popular peripheral nerve block that has been shown to decrease pain significantly and thereby opioid consumption with minimal effect on quadriceps function \[8\]. Though ACB provides analgesia to the peripatellar and intra-articular aspect of knee joint, it does not relieve posterior knee pain which is moderate to severe in intensity \[9, 10\]. The recent technique of an ultrasound (US)-guided local anesthetic infiltration of the interspace between popliteal artery and the capsule of posterior knee (IPACK) has shown to provide significant posterior knee analgesia without affecting the common peroneal nerve (CPN) \[11\]. We postulated that IPACK will provide better pain relief and improve knee function in the immediate postoperative period compared to ACB
Study: NCT04943770

Intervention type: PROCEDURE
Intervention: Spinal cord stimulator implant
Description: Patients will undergo spinal cord implant procedures as per standard of care and be implanted with the WaveWriter™ Alpha Spinal Cord Stimulator (SCS) system.~Implant Procedures will be followed by a healing period (4-6 weeks) during which patients will be offered therapy (up to one 1Khz). Patients will then be randomised to receive therapy at four different rates (A, B, C, D) in no particular order for 3-6 weeks each. Patients will then be followed up at 3 and 6 months after the last randomization visit.

Intervention type: DIAGNOSTIC_TEST
Intervention: Healing period
Description: Acute opioid pain medications may be continued. No additional scheduled assessments will be completed during this period.

Intervention type: DEVICE
Intervention: WaveWriter™ Alpha Spinal Cord Stimulator (SCS) system
Description: Patients will then be randomised to receive therapy (up to 1KHz) at four different rates in no particular order for 3-6 weeks each. Patients will then be followed up at 3 and 6 months after the last randomization visit.
Study: NCT05943171

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy
Description: All participants will receive Cognitive Behavioral Therapy. They will be randomized to either Digital RITch®CBT or Standard CBT

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Behavioral Therapy
Description: All participants will receive Cognitive Behavioral Therapy. They will be randomized to either Digital RITch®CBT or Standard CBT
Study: NCT05404906

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azacitidine
Description: Given SC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Given PO

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supportive care
Description: Patients will receive disease monitoring and supportive care for any complication.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Supportive care
Description: Patients will receive disease monitoring and supportive care for any complication.
Study: NCT05235698

Intervention type: PROCEDURE
Intervention: Ophthalmological examinations
Description: Visual acuity, slit lamp examination, eye pressure, retinophotography, indocyanine green retinal angiography, OCT-A( Optical Coherence Tomography- Angiography), adaptive optics, automated visual field

Intervention type: PROCEDURE
Intervention: GlycoCheck
Description: Evaluation of the glycocalyx of sublingual capillaries with the GlycoCheck :~A sidestream dark field camera, coupled with GlycoCheck™ software is used to visualize the patient's sublingual microvascularization
Study: NCT04431388

Intervention type: DEVICE
Intervention: ultrasound device
Description: We performe a differnt analgesic techniques to know if some of then are better

Intervention type: DEVICE
Intervention: ultrasound device
Description: We performe a differnt analgesic techniques to know if some of then are better

Intervention type: DRUG
Intervention: Levobupivacaine
Description: using the same AL

Intervention type: DRUG
Intervention: Levobupivacaine
Description: using the same AL
Study: NCT05838495

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: formulated liquid diet
Description: will be fed exclusively the pediatric enteral study formula with a feeding tube
Study: NCT06375265

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: digital Cognitive Behavioral Therapy for Insomnia (dCBT-I)
Description: Preoperative hybrid intervention (in-person or via phone/video) over 4 weeks using content from the CBT-I Coach app from Veteran Affairs.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Sleep Health Education
Description: Sleep Health Education materials provided
Study: NCT05686421

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device N
Description: Standard conventional OCT imaging device equipped with extendable and comfortable chin and forehead rest.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device N
Description: Standard conventional OCT imaging device equipped with extendable and comfortable chin and forehead rest.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device N
Description: Standard conventional OCT imaging device equipped with extendable and comfortable chin and forehead rest.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device N
Description: Standard conventional OCT imaging device equipped with extendable and comfortable chin and forehead rest.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device C
Description: Standard conventional OCT imaging device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device C
Description: Standard conventional OCT imaging device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device C
Description: Standard conventional OCT imaging device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: OCT Imaging Using Device C
Description: Standard conventional OCT imaging device.
Study: NCT06289348

Intervention type: BEHAVIORAL
Intervention: socio-psychological questionnaire
Description: ton collecte socio-demographic variable

Intervention type: BEHAVIORAL
Intervention: socio-psychological questionnaire
Description: ton collecte socio-demographic variable

Intervention type: BEHAVIORAL
Intervention: revised event impact scale (IER-S)
Description: 22 items assessed on a scale of frequency from 0 (not at all) to 4 (extremely)

Intervention type: BEHAVIORAL
Intervention: revised event impact scale (IER-S)
Description: 22 items assessed on a scale of frequency from 0 (not at all) to 4 (extremely)

Intervention type: OTHER
Intervention: Non directive interview
Description: composed of a very broad opening sentence to encourage the parents' discourse
Study: NCT06393751

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Given IV

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Bevacizumab
Description: Given IV

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Given IV

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Computed Tomography
Description: Undergo CT

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI
Study: NCT06289348

Intervention type: OTHER
Intervention: Stern interview
Description: 54 questions to investigate the impact of the announcement and the parenthood construction

Intervention type: OTHER
Intervention: semi-directive interview
Description: to propose ideas for improving and harmonizing practices

Intervention type: OTHER
Intervention: semi-directive interview
Description: to propose ideas for improving and harmonizing practices
Study: NCT04595266

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Anti-EGFR or Bevacizumab
Description: In case of RAS wt colorectal cancer administer anti-EGFR together with FOLFOX6m, and in case of mutated RAS colorectal cancer administer Bevacizumab together with FOLFOX6m.~Treatment administered following Summary of medicinal Product Characteristics (SmPC) approved indications.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LIVERPEARLS-Irinotecan
Description: Chemoembolization of Irinotecan in 100 +/- 50 micron hydrogel microspheres. Irinotecan will be loaded at a dose of 100 mg. LIFEPEARLS® is a CE marked medical device consisting of microspheres for use in chemoembolization. This device allows the continuous release of irinotecan in liver tumors causing a specific necrosis. The penetration of irinotecan into the tumor tissue is deeper thanks to the microspheres, avoiding proximal occlusion of the vessels supplying the tumor.
Study: NCT06480812

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Synbiotic
Description: The proposed protocol will provide a simple but robust intervention study using a synbiotic (pre and probiotic combination) in order to improve our understanding of the mechanisms linking nutrition to health outcomes that are mediated by the gut microbiome.~This pilot study will comprise a controlled randomised intervention in which participants will be grouped into the active synbiotic arm or the control arm. The ratios will be 10g of the prebiotic supplement and 170ml of kefir. Randomisation will control for equal distribution of age and biological sex; characteristics that may confound between group comparisons and will be assessed by analysis of baseline data.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Synbiotic
Description: The proposed protocol will provide a simple but robust intervention study using a synbiotic (pre and probiotic combination) in order to improve our understanding of the mechanisms linking nutrition to health outcomes that are mediated by the gut microbiome.~This pilot study will comprise a controlled randomised intervention in which participants will be grouped into the active synbiotic arm or the control arm. The ratios will be 10g of the prebiotic supplement and 170ml of kefir. Randomisation will control for equal distribution of age and biological sex; characteristics that may confound between group comparisons and will be assessed by analysis of baseline data.
Study: NCT05273931

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lifestyle intervention
Description: Documents explaining the strategies to achieve and maintain recommended behaviours as part of a healthier lifestyle
Study: NCT05871086

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Coenzyme Q10
Description: Coenzyme Q10 soft gelatin capsules daily for 3 months

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo Capsules

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard Regimen
Description: Patients may be receiving any of these commonly used JIA treatments including:~* Ibuprofen - 30 to 40 mg/kg/day in 3 to 4 divided doses~* Diclofenac - 2 to 3 mg/kg/day in divided doses 2 to 3 times daily~* Methotrexate - Initial: 10 to 15 mg/m2 once weekly; adjust gradually up to 20 to 30 mg/m2 once weekly~* Leflunomide - Weight based, 10-20 mg once daily~* Sulfasalazine - 30 to 50 mg/kg/day in 2 divided doses~* Etanercept - 0.8 mg/kg/dose once weekly~* Adalimumab - Weight based, 10-40 mg every other week

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Standard Regimen
Description: Patients may be receiving any of these commonly used JIA treatments including:~* Ibuprofen - 30 to 40 mg/kg/day in 3 to 4 divided doses~* Diclofenac - 2 to 3 mg/kg/day in divided doses 2 to 3 times daily~* Methotrexate - Initial: 10 to 15 mg/m2 once weekly; adjust gradually up to 20 to 30 mg/m2 once weekly~* Leflunomide - Weight based, 10-20 mg once daily~* Sulfasalazine - 30 to 50 mg/kg/day in 2 divided doses~* Etanercept - 0.8 mg/kg/dose once weekly~* Adalimumab - Weight based, 10-40 mg every other week
Study: NCT06657768

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY4006895
Description: Administered IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY4006895
Description: Administered IV

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered IV

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administered IV
Study: NCT06605807

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinical Decision Framework for Managing older adults' chronic conditions during hospitalization.
Description: All clinicians will attend an educational session where they will be provided a clinical decision framework for management of chronic conditions in hospitalized older adults, reviewing guiding principles for managing chronic disease in the hospital, and working through case-based hypothetical examples.
Study: NCT06595147

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Structured Exercise Training
Description: Participants will complete 12-weeks of supervised, structured moderate-to-high intensity aerobic and resistance training three times per week.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Group-based Yoga and Stretching
Description: Participants will complete 12-weeks of supervised group-based yoga and stretching once per week.
Study: NCT04978844

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: IWOTCH
Description: Arm 1

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Dyadic therapy
Description: Arm 2
Study: NCT00718406

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Metoprolol

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: metoprolol plus morphine
Study: NCT06201819

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Liraglutide injection
Description: Liraglutide (GLP-1 analog) injection during 3 months
Study: NCT06028282

Intervention type: RADIATION
Intervention: SPECT
Description: SPECT of thyroid traced with I-131
Study: NCT05175248

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Plant-based Intervention Group
Description: Participants in the intervention group will be instructed in ways to adopt a plant-based diet, use appropriate methods of food preparation, and make meals enjoyable and appetizing. The plant-based diet primarily emphasizes whole grains, vegetables, beans and legumes, and fruits. Animal products and added oils will be proscribed and the use of ultra-processed foods, sugar, and sugar-sweetened beverages will be discouraged. Fat intake will be limited to 20-30 g/day.
Study: NCT05089084

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plozasiran
Description: ARO-APOC3 injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: sterile normal saline (0.9% NaCl)
Study: NCT05715268

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: WeB
Description: Participants will be given WeB devices and trained on the use of these devices for home therapy, including the associated mobile applications. Participants will be given home programs and given a schedule to use the WeB devices at home on their own time. At their standard visit participants will have their WeB device use checked and progressed as the therapist deems appropriate.~An in-person visit will be scheduled to re-evaluated participants at the 12 week study completion.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard pelvic floor physical therapy
Description: Baseline will consist of a standard PFPT evaluation. Regular visits (tele-video visits or in-person depending on the patients preference) will be scheduled every week for the first 4 weeks and then every other week at the discretion of the therapist. A total of 8-10 visits will be scheduled over the 12 weeks of the study. Participants will be given home exercise programs (as per standard PFPT).~An in-person visit will be scheduled to re-evaluated participants at the 12 week study completion.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard pelvic floor physical therapy
Description: Baseline will consist of a standard PFPT evaluation. Regular visits (tele-video visits or in-person depending on the patients preference) will be scheduled every week for the first 4 weeks and then every other week at the discretion of the therapist. A total of 8-10 visits will be scheduled over the 12 weeks of the study. Participants will be given home exercise programs (as per standard PFPT).~An in-person visit will be scheduled to re-evaluated participants at the 12 week study completion.
Study: NCT05134025

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pump settings
Description: Alteration in the pump setting prior to exercise commencement

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pump settings
Description: Alteration in the pump setting prior to exercise commencement

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pump settings
Description: Alteration in the pump setting prior to exercise commencement
Study: NCT05678972

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Self-help online mindfulness-based intervention
Description: This self-help online mindfulness-based intervention is comprised of four weekly modules on education about mindfulness, guided meditations (e.g., mindful breathing, mindful eating, mindful walking, body scan, acceptance, choiceless awareness and disengaging from thoughts exercise), and guidance on using informal mindfulness skills in day-to-day life. Readings, audio and videos are included to explain the concept of mindfulness and overcome common difficulties associated with mindfulness practice.~Participants will be asked to meditate daily and complete a daily log on their mindfulness practice during this 8-week period.
Study: NCT05291598

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV meloxicam
Description: Participants will be administered meloxicam 30 mg IV push pre-operatively.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ketorolac
Description: Participants will be treated with ketorolac 15 mg IV push intra-operatively, followed by 15 mg IV push every 6 hours scheduled for 2 doses.