TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05807919

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Diet low in all FODMAP groups
Description: Randomized participants will eat this diet for 4 weeks (all meals and snacks will be provided). Participants will only eat the study food for this intervention. Participants will be asked to complete surveys, food diaries, and have blood and stools samples pre and post treatment.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Diet - Mediterranean
Description: Randomized participants will eat this diet for 4 weeks (all meals and snacks will be provided). Participants will only eat the study food for this intervention. Participants will be asked to complete surveys, food diaries, and have blood and stools samples pre and post treatment.
Study: NCT05271409

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Satralizumab
Description: Study drug will be administered by SC injection in the abdominal or femoral region after all other study-related procedures have been performed at a site visit.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will be administered by SC injection in the abdominal or femoral region after all other study-related procedures have been performed at a site visit.
Study: NCT06370598

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TP-122A
Description: Bacteriophage cocktail targeting Psa
Study: NCT06100627

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AP301
Description: Orally administered

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AP301
Description: Orally administered
Study: NCT06405776

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: In the placebo group, the same volume of normal saline will be administered during anesthesia. The postoperative PCIA device will contain sufentanil 2μg/kg, granisetron 12mg diluted to 200 mL in 0.9% normal saline solution with a total volume of 200 mL.
Study: NCT05334693

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Expanded haploidentical NK cells
Description: Two doses of expanded haploidentical NK cells (30-100 x 10\^6 cells /kg).
Study: NCT04917159

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ACT (Acceptance and Commitment Therapy) plus brief CHF education
Description: The participants will identify their values and clarify their alternative behavior, exploring their thoughts and feelings, and finding ways to meet their own and their family member's needs. The rational bond between the patient and his/her family caregiver will be emphasized. In addtion, the contents of brief CHF education are based on the latest national clinical practice guideline for CHF, including symptoms monitoring, medication adherence, fluid and salt restriction, smoking cessation, alcohol consumption, and physical activity maintenance.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: HE (Health Education)
Description: The educational contents are based on the latest national clinical practice guideline for CHF. Besides the basic information on CHF education provided in intervention group, the contents of CHF education also include definition of CHF, epidemiology, diagnosis, comorbidity, and CHF treatment. ACT components are not covered.
Study: NCT05978050

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: nimotuzumab plus paclitaxel
Description: Nimotuzumab injection: 50mg/10ml/stick Paclitaxel: 30mg/5ml/stick

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: placebo plus paclitaxel
Description: placebo: 50mg/10ml/stick Paclitaxel: 30mg/5ml/stick
Study: NCT06548373

Intervention type: DIAGNOSTIC_TEST
Intervention: Artificial Intelligence-assisted Point-of-Care Echocardiography
Description: A wireless, AI-guided handheld ultrasound probe will be used on adult male patients who present with a clinical indication for peri-anesthesia point-of-care echocardiography examination.~Residents will document personal interpretation of the completed point-of-care ultrasound (POCUS) examination, important clinical findings, and assessment of whether obtaining a formal echocardiogram is warranted on an exam assessment form. The residents will complete 11 examinations with 10 specific scans each. The first 10 examinations will be AI-guided, and the final 11th examination will be done via a standard (non-AI guided) ultrasound system to gauge the resident's growth in point-of-care echocardiography skill.
Study: NCT06572059

Intervention type: OTHER
Intervention: assesments for once
Description: * EDSS score (patient reports recorded in the physician's record will be used.)~* Demographic information~* Fatigue Severity Scale (FSS)~* Beck Depression Inventory (BDI)~* Kinesthetic and Visual Imagery Questionnaire (KSVI)~* Mental Chronometer Test (Nine-Hole Peg Test (DDPT)) will be used.)~* Jebson-Taylor Hand Function Test (JHEFT)~* Manual Ability Test (MAM-36)~* Multiple Sclerosis Impact Scale (MSIS-29)

Intervention type: OTHER
Intervention: assesments for once
Description: * EDSS score (patient reports recorded in the physician's record will be used.)~* Demographic information~* Fatigue Severity Scale (FSS)~* Beck Depression Inventory (BDI)~* Kinesthetic and Visual Imagery Questionnaire (KSVI)~* Mental Chronometer Test (Nine-Hole Peg Test (DDPT)) will be used.)~* Jebson-Taylor Hand Function Test (JHEFT)~* Manual Ability Test (MAM-36)~* Multiple Sclerosis Impact Scale (MSIS-29)
Study: NCT06571721

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Topical Product: Almond Oil
Description: 1-2 Drops of randomized topical product will be applied on entire face nightly.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Topical Product: Almond oil augmented with 0.5% Vitamin E
Description: 1-2 Drops of randomized topical product will be applied on entire face nightly.
Study: NCT04778527

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dual Prevention Pill
Description: a single over-encapsulated DPP containing a PrEP tablet and a COC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PrEP tablet and a COC as two separate tablets
Description: PrEP tablet and a COC as two separate tablets
Study: NCT05958277

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vitamin B3
Description: Vitamin B3 upto 16 mg/day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vitamin B12
Description: Vit B12 upto 250 mcg per day
Study: NCT05416658

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: The Antipsychotic Medication Decision Aid (APM-DA)
Description: The APM-DA intervention is the first and only International Patient Decision Aid Standards (IPDAS) approved shared decision making (SDM) decision aid intervention for Antipsychotic Medication decisions in psychiatric visits. The APM-DA intervention developed by the research team addresses a common issue among psychiatric care providers and patients that lies in the heart of pharmacotherapy - taking, tapering or stopping APM. The APM-DA has a print format and can be used online as a PDF. It includes a concise table describing what each option involves, its benefits, risks, and strategies to reduce risks. The intervention was developed in co-production with various stakeholders (patients, clinicians, service leadership, family members, researchers). Additional intervention materials are an evidence document to support the information and an APM side effects table.
Study: NCT04878978

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Amniocentesis
Description: Amniocentesis will be used to sample the amniotic fluid for Biofire detection of microorganism and to direct antibiotic treatment

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Routine care without amniocentesis
Description: Routine clinical care
Study: NCT05435612

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: cochlear implant
Description: Patients enrolled in the study undergo the cochlear implant surgery.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: cochlear implant
Description: Patients enrolled in the study undergo the cochlear implant surgery.
Study: NCT06350123

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Balcinrenone/dapagliflozin 15 mg/10 mg and matching placebo for dapagliflozin 10 mg
Description: 1 capsule of balcinrenone/dapagliflozin 15 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Balcinrenone/dapagliflozin 40 mg/10 mg and matching placebo for dapagliflozin 10 mg
Description: 1 capsule of balcinrenone/dapagliflozin 40 mg/10 mg and 1 tablet of matching placebo for dapagliflozin 10 mg once daily, oral use

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dapagliflozin 10 mg and matching placebo for balcinrenone/dapa gliflozin
Description: 1 tablet of dapagliflozin 10 mg and 1 capsule of matching placebo for balcinrenone/dapagliflozin once daily, oral use
Study: NCT06667115

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PNF exercise
Description: Foundational PNF D2 shoulder flexion exercise incorporating shoulder flexion, abduction, and external rotation. This exercise was performed at a metronome-guided pace of 14 beats per minute to establish a consistent baseline.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PNF exercise
Description: Foundational PNF D2 shoulder flexion exercise incorporating shoulder flexion, abduction, and external rotation. This exercise was performed at a metronome-guided pace of 14 beats per minute to establish a consistent baseline.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PNF exercise with virtual reality gaming
Description: Combined the PNF D2 shoulder flexion exercise with a virtual reality motion capture game (the U-Ball game).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PNF exercise with virtual reality gaming
Description: Combined the PNF D2 shoulder flexion exercise with a virtual reality motion capture game (the U-Ball game).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PNF with concurrent feedback
Description: PNF exercise with the addition of auditory concurrent feedback (Sword) which referenced the action of unsheathing a sword in a diagonal upward direction.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: PNF with concurrent feedback
Description: PNF exercise with the addition of auditory concurrent feedback (Sword) which referenced the action of unsheathing a sword in a diagonal upward direction.
Study: NCT06069622

Intervention type: DIAGNOSTIC_TEST
Intervention: 24-hour ambulatory blood pressure
Description: 24-hour ambulatory blood pressure, blood, and urine will be obtained prior to semaglutide therapy and after 20 weeks of semaglutide therapy.

Intervention type: DIETARY_SUPPLEMENT
Intervention: Liberal salt diet
Description: Participants will be on a liberal salt (about 200 mEq sodium/day) diet for 7 days.
Study: NCT06670781

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Experimental: Intervention arm: Goal-Directed Valsalva maneuver
Description: For the Goal directed Valsalva maneuver, the same method patients are instructed to blow into a plastic pipe connected to the manometer device, in order to reach a pressure of 40 mmHg for at least 5 seconds. Then patients are instructed to exhale quickly.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Experimental: Intervention arm: Goal-Directed Valsalva maneuver
Description: For the Goal directed Valsalva maneuver, the same method patients are instructed to blow into a plastic pipe connected to the manometer device, in order to reach a pressure of 40 mmHg for at least 5 seconds. Then patients are instructed to exhale quickly.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Control - standard of care: Self-Directed Valsalva maneuver
Description: The Valsalva maneuver is performed by the patient taking a normal (or deep) inspiration, followed by forceful expiration against a closed airway for up to 15 to 20 sec and then release of the expiratory effort on entry of saline into the right atrium.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Control - standard of care: Self-Directed Valsalva maneuver
Description: The Valsalva maneuver is performed by the patient taking a normal (or deep) inspiration, followed by forceful expiration against a closed airway for up to 15 to 20 sec and then release of the expiratory effort on entry of saline into the right atrium.
Study: NCT06670222

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arsenic Trioxide (ATO)
Description: Study treatment: oral Arsenic 5d/7 for 21 days over a 28-day cycle, three doses tested (0.10 mg/kg, 0.15 mg/kg and 0.20 mg/kg).~Dose escalation cohort to determine the dose limiting toxicity according to a BOIN (Bayesian optimal interval) scheme, 9 patients will be treated at each dose.~An expansion cohort at the selected dose will be conducted with 6 patients.~Tolerability will be assessed after one treatment cycle. Response will be assessed after 3 cycles of treatment. Responders may continue study treatment until progression or limiting toxicity. Limiting toxicity is defined as any grade III/IV extra-hematological toxicity or grade IV hematological toxicity lasting more than 25 days.
Study: NCT06170827

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AIO-001
Description: AIO-001 Solution for SC injection.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AIO-001
Description: AIO-001 Solution for SC injection.
Study: NCT06571721

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Topical Product: 0.025% Tretinoin oil augmented with castor oil
Description: 1-2 Drops of randomized topical product will be applied on entire face nightly.
Study: NCT06329856

Intervention type: BEHAVIORAL
Intervention: Administering of artificial hydration
Description: Administering of artificial hydration to terminal cancer patients

Intervention type: BEHAVIORAL
Intervention: Administering of artificial hydration
Description: Administering of artificial hydration to terminal cancer patients
Study: NCT06269926

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy for Chronic Pain
Description: Treatment for chronic pain that addresses the relationship between thoughts, feelings and behaviors.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy for Chronic Pain
Description: Treatment for chronic pain that addresses the relationship between thoughts, feelings and behaviors.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pain education
Description: A booklet on chronic pain (in this study, an educational pamphlet from the Oregon state health department) that provides pain education in addition to usual medical care.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pain education
Description: A booklet on chronic pain (in this study, an educational pamphlet from the Oregon state health department) that provides pain education in addition to usual medical care.
Study: NCT06670209

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GZR18 and metformin
Description: GZR18: 3 mg-18 mg Metformin: 500 mg
Study: NCT06669507

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Chronotherapy
Description: 1. The effect of light exposure follows a phase-response curve where circadian phase advancement is strongest in the biological morning, whereas light in the biological evening/night may lead to a phase delay. Light therapy is provided by 30 min light exposure using 10 000 lux light boxes.~2. Melatonin 3 milligram is prescribed in tablet forms (not depot), usually 12 hours before the planned rise time.~3. Additionally, blue-light-blocking glasses are used to block light exposure at night, which has been found to advance circadian rhythms. Patients are advised to wear their blue-blocking glasses 12 hours before rise time.~Which chronotherapeutic interventions that are used, is considered individually by the clinicians in the Sleep Clinic, but often all three treatment components are used at the same time. Duration of chronotherapy given in the Sleep Clinic vary from 4 to 8 consultations over 1 to 4 months depending on the patients' needs and progress during treatment.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Cognitive Behavioral Therapy for Insomnia
Description: All participants will receive treatment as usual. CBT-I has several components and consists of the following interventions including psychoeducation about sleep: sleep hygiene, sleep restriction therapy, stimulus control, and challenging beliefs and perceptions of sleep. Special emphasis is placed on providing a rationale for behavior change as a primary means of improving sleep as well as addressing dysfunctional beliefs the patients may hold about sleep. During treatment, tapering sleep medication is not necessary. However, if the patients are motivated to do so, this is discussed and a plan for tapering is provided. Treatment duration is typically between 4 to 8 consultations over 1 to 4 months depending on the patients' needs and progress during treatment.
Study: NCT06669845

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Ultrasonography, Pelvic
Description: Ultrasound measurements will be taken before and after bladder emptying. The axes of the uterine body, cervix and vagina will be marked out by tracing the 3 corresponding lines on the image.
Study: NCT06669273

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: CEST MRI sequence at 3T
Description: The MRI will be performed at the Clermont Ferrand University Hospital on the 3T research MRI on a Siemens MRI system (MAGNETOM VIDA, Siemens Healthcare, Erlangen, Germany), the emission of the radiofrequency pulses and the reception of the signal will be done using a coil dedicated to the abdo-pelvic region. The images will be analyzed by the radiologist.~MRI is non-irradiating medical imaging. It is practiced according to good practices and the recommendations of the French Society of Radiology.~* Acquisition of morphological T1, T2 sequences for the identification of areas of interest on the pelvic area.~* Acquisition of the CEST MRI sequence (acquisition time 5 min)~* Acquisition of functional sequences, DWI diffusion-weighted images and dynamic DCE sequence after injection of a single dose of non-linear gadolinum.~The imaging report will reveal the presence or absence of tumor lesions in the prostate and their location. Data will then be compared to the histopathological analysis.
Study: NCT06092970

Intervention type: DRUG
Intervention: RBT-1
Description: Intravenous administration

Intervention type: DRUG
Intervention: Placebo
Description: Intravenous administration
Study: NCT05399953

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Myofascial Release Technique
Description: Sternocleidomastoid, Upper trapezius, Suboccipital region, Scalenes, Pectoral release, Scapular and hyoid mobilization techniques.~Duration: 6 weeks, 1 supervised session per week, and the session lasted 30 minutes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercise
Description: Therapeutic exercise: passive and active range of motion, strengthening and postural exercise in order to improve shoulder and cervical mobility, muscle flexibility, strength and endurance, postural control and movement patterns; 2) stretching of pectoral muscles and serratus anterior; 3) scar tissue massage to reduce scar tissue's stiffness.~Duration of the intervention: 6 weeks (1 supervised session and 2 individual per week). Each exercise will be done 1-3 sets and 5-10 repetitions.The session lasted 30 minutes.~Exercise diary will be utilized in order to follow the exercise program.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise
Description: Therapeutic exercise: passive and active range of motion, strengthening and postural exercise in order to improve shoulder and cervical mobility, muscle flexibility, strength and endurance, postural control and movement patterns; 2) stretching of pectoral muscles and serratus anterior; 3) scar tissue massage to reduce scar tissue's stiffness.~Duration of the intervention: 6 weeks (1 supervised session and 2 individual per week). Each exercise will be done 1-3 sets and 5-10 repetitions.The session lasted 30 minutes.~Exercise diary will be utilized in order to follow the exercise program.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Scar Tissue Massage
Description: Circular, Up and Down, Side to Side technique

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Scar Tissue Massage
Description: Circular, Up and Down, Side to Side technique
Study: NCT06750614

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: intermittent theta-burst stimulation (iTBS)
Description: In each visit, the intensity of the iTBS applied to the participant will be set at 70% of their individual resting motor threshold (rMT), with one session specifically targeting the left DLPFC.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: intermittent theta-burst stimulation (iTBS)
Description: In each visit, the intensity of the iTBS applied to the participant will be set at 70% of their individual resting motor threshold (rMT), with one session specifically targeting the left DLPFC.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: intermittent theta-burst stimulation (iTBS)
Description: In each visit, the intensity of the iTBS applied to the participant will be set at 70% of their individual resting motor threshold (rMT), with one session specifically targeting the left DLPFC.
Study: NCT06754969

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Peripheral Nerve Regenerative Interface (RPNI) and Nerve/Muscle Biopsy
Description: RPNI is a surgical technique which wraps denervated muscle targets around severed nerve ends.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Biopsy Alone
Description: Sural nerve and muscle biopsy performed in the standard fashion.
Study: NCT06776692

Intervention type: DRUG
Intervention: Qdenga
Description: Administration of Dengue vaccine and blood sample collection
Study: NCT06777472

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: lung-benefiting moxibustion
Description: A kind of external treatment，the treatment theory is to treat winter diseases in summer.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: The specific drug comes from GINA (2024)
Description: Refer to GINA (2024).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: The specific drug comes from GINA (2024)
Description: Refer to GINA (2024).