TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05898035

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Endodontic Microsurgery
Description: Osteotomy will be done either with air motor high speed hand-piece and round bur with copious irrigation or with Piezosurgery touch. After the soft tissue curettage and uncovering the root apex , the last 3 mm of the root apex will be resected perpendicular to the long axis of the tooth at ( 0 - 10) degree bevel , using either conventional dental hand-piece or piezotome (Piezotome Cube by ACTEON ).The resected root will be rinsed , dried and and stained with 1% methylene blue dye after which , it will be inspected carefully under high magnification, to identify possible reasons for the non surgical root canal treatment failure. Subsequently, ultrasonic apical preparation will be performed. After achieving adequate haemostasis with Epinephrine pellets. Biodentine®retrograde filling material will be placed. The flap will be re-approximated and interrupted suture using non-absorbable monofilament size 5-0 suture will be applied. Finally, Post-operative parallel Digital view.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endodontic Microsurgery
Description: Osteotomy will be done either with air motor high speed hand-piece and round bur with copious irrigation or with Piezosurgery touch. After the soft tissue curettage and uncovering the root apex , the last 3 mm of the root apex will be resected perpendicular to the long axis of the tooth at ( 0 - 10) degree bevel , using either conventional dental hand-piece or piezotome (Piezotome Cube by ACTEON ).The resected root will be rinsed , dried and and stained with 1% methylene blue dye after which , it will be inspected carefully under high magnification, to identify possible reasons for the non surgical root canal treatment failure. Subsequently, ultrasonic apical preparation will be performed. After achieving adequate haemostasis with Epinephrine pellets. Biodentine®retrograde filling material will be placed. The flap will be re-approximated and interrupted suture using non-absorbable monofilament size 5-0 suture will be applied. Finally, Post-operative parallel Digital view.
Study: NCT05641571

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The home-based extremity exercise program
Description: Participants have to perform a total of 50 minutes of exercise including the Ten Skilled Hand exercise fourth a day, 5 minutes each time and Buerger Allen exercise twice a day, 15 minutes each time before chemotherapy to the completion of chemotherapy.
Study: NCT06487429

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Short range radiotherapy with sequential Disitamab Vedotin combined with S-1 and xindilizumab
Description: Short range radiotherapy, PCTV (clinical planned target area) DT 25Gy/5F, once a day, for a total of 5 days, continuous irradiation, and IMRT (intensity modulated radiation therapy) technology; After a week of rest, radiotherapy and chemotherapy combined with immunotherapy will be performed~* Disitamab Vedotin: 2.5 mg/kg, intravenous infusion, d1, Q3W;~* Sintilimab: 200mg, iv;~* S-1: 40 mg/dose, oral, bid, d1-14; Q3W Whether to undergo adjuvant therapy after surgery is determined by the researcher
Study: NCT05718089

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Continuous aerobic exercise
Description: The Continuous aerobic exercise session will be performed in total two times, as it will be repeated in sets on consecutive weeks (e.g. Two Tuesdays in a row) with a 1-week wash-out period. The  Continuous aerobic exercise intervention is matched to the other arms on the time spend for each bout equating a total of 50 minutes of exercise per session.~An oral glucose tolerance test will be performed 24 hours and 48 hours after the exercise bout.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High intensity interval training
Description: The High intensity interval training session will be performed in total two times, as it will be repeated in sets on consecutive weeks (e.g. Two Tuesdays in a row) with a 1-week wash-out period. The High intensity interval training intervention is matched to the other arms on the time spend for each bout equating a total of 50 minutes of exercise per session.~An oral glucose tolerance test will be performed 24 hours and 48 hours after the exercise bout.
Study: NCT04577066

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: GA2
Description: 15 volunteers will receive 50 GA2-infected mosquito bites. The GA2 parasite is a new genetically attenuated Plasmodium falciparum parasite, which arrests development in the liver and should not be able to cause malaria in humans.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: GA1
Description: 10 volunteers will receive 50 GA1-infected mosquito bites. The GA1 parasite is a genetically attenuated Plasmodium falciparum parasite, which arrests development in the liver and is not able to cause malaria in humans.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 5 volunteers will receive 50 uninfected mosquito bites.
Study: NCT05718089

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Resistance training
Description: The Resistance training session will be performed in total two times, as it will be repeated in sets on consecutive weeks (e.g. Two Tuesdays in a row) with a 1-week wash-out period. The Resistance training intervention is matched to the other arms on the time spend for each bout equating a total of 50 minutes of exercise per session.~An oral glucose tolerance test will be performed 24 hours and 48 hours after the exercise bout.
Study: NCT05871307

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Preoperative Radiotherapy
Description: Resection of brain mestases following

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intraoperative Radiation
Description: While Resection

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Postoperative Radiotherapy
Description: After resection
Study: NCT06094816

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Furosemide (Diuretic)
Description: The diuretic furosemide will be given during a 3% hypertonic saline infusion to examine blockade of the NKCC2.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Furosemide (Diuretic)
Description: The diuretic furosemide will be given during a 3% hypertonic saline infusion to examine blockade of the NKCC2.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hypertonic Saline Infusion
Description: 3% Hypertonic saline infusion to acutely increase sodium and osmolality

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hypertonic Saline Infusion
Description: 3% Hypertonic saline infusion to acutely increase sodium and osmolality
Study: NCT06221709

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Conventional Radiofrequency (CRF group)
Description: Radiofrequency will be performed with a 22-gauge CRF cannula, 10/15 cm long, 10mm curved active tip, at 90º for 90 seconds, introduced in the anteroposterior and lateromedial directions, to reach the teardrop landmark. Denervation of the articular branches of the Obturator Nerve will be performed in 2 cycles, starting lateral to the lateral edge of the obturator foramen, followed by a point approximately 1cm lateral to the first point. Next, the cannula will be repositioned in a more cranial location, parallel to the superolateral edge of the acetabular dome, to reach the sensory branches of the Femoral Nerve, performing 3 cycles at the 01, 12, and 11 o'clock positions. All lesions will be preceded by motor stimulation at 2,5V and cycles will be followed by the infusion of 2ml of 1% ropivacaine. After concluding the procedure, hip intraarticular infiltration will be performed as described for the control group.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Intraarticular Infiltration ( Control group)
Description: For the control group (IA), an epidural anesthesia needle (22G spinal needle) will be used, positioned anteroposteriorly towards the central portion of the femoral neck, which will be introduced until transfixion of the anterior hip capsule through tactile sensitivity. After checking the correct positioning with the use of fluoroscopy and infusion of 3 ml of 50% diluted iodinated contrast, an infusion of 4 ml of 1% Ropivacaine and 80mg of methylprednisolone 40mg/ml will be done.
Study: NCT05661448

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive remediation
Description: The goal of this program is to improve performance on cognitive domains known to hinder functioning. It aims to promote positive attitudes towards learning and facilitate the development of independent learning skills to foster competence and confidence. Another aim is to increase patients' awareness of their cognitive strengths and weaknesses and their own problem solving strategies.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MetaCognitive Training
Description: The metacognitive training (MCT) program is based on the theoretical foundations of cognitive models of schizophrenia but employs a slightly different focus in its therapeutic approach targeting the specific cognitive biases underlying delusions. The modules aim to raise awareness of these biases and prompts participants to critically reflect on and update their problem-solving repertoire.
Study: NCT04744298

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: TheraPPP
Description: TheraPPP Steps:~Step 1. All mechanically ventilated patients will have a height measured and documented. Step 2. Screening for HRF. Step 3. Initiate Lung Protective Ventilation (LPV). Step 4. Paralysis. Step 5. Prone Positioning.
Study: NCT04072874

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Experimental topical (Curaleish Topical)
Description: Curaleish is a formulation in lotion and cream. Curaleish lotion and Curaleish cream will be applied topically by each participant in all lesion until day 28 or 42, depending on the regimen to be evaluated. Study staff will be closely observing the safety assessment. The application until Day 28 or 42 will continue, even if the lesion has shown 100% re-epithelization before day 28 or day 42.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Experimental topical (Curaleish Topical)
Description: Curaleish is a formulation in lotion and cream. Curaleish lotion and Curaleish cream will be applied topically by each participant in all lesion until day 28 or 42, depending on the regimen to be evaluated. Study staff will be closely observing the safety assessment. The application until Day 28 or 42 will continue, even if the lesion has shown 100% re-epithelization before day 28 or day 42.
Study: NCT06297759

Intervention type: OTHER
Intervention: Questionnaire
Description: Sense of Competence in Dementia Care Staff (SCIDS) Scale
Study: NCT05785962

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Vojta Therapy
Description: The therapy consists of the application of a stimulating pressure in the pectoral area in the pattern of the locomotion complex of reflex rolling in its first phase. For this, the subject will be placed in a supine position aligned with respect to the axial axis, with the arms along the body, the lower extremities in extension, and the head extended with a rotation of approximately 30º towards one side of the stimulation. The manual stimulation pressure will be exerted in the space between the 6th-7th or the 7th-8th rib under the mammillary line, with a force of about 2 kg.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Vojta Therapy
Description: The therapy consists of the application of a stimulating pressure in the pectoral area in the pattern of the locomotion complex of reflex rolling in its first phase. For this, the subject will be placed in a supine position aligned with respect to the axial axis, with the arms along the body, the lower extremities in extension, and the head extended with a rotation of approximately 30º towards one side of the stimulation. The manual stimulation pressure will be exerted in the space between the 6th-7th or the 7th-8th rib under the mammillary line, with a force of about 2 kg.
Study: NCT05528419

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sacubitril-valsartan
Description: sacubitril valsartan 100mg initiated, and titrated to 200mg according to mean clinic blood pressure at 1-month follow-up

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Valsartan
Description: valsartan 80mg initiated, and titrated to 160mg according to mean clinic blood pressure at 1-month follow-up
Study: NCT01028313

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LBH589
Description: 20 mg PO three times weekly

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methylprednisolone
Description: 1 mg/kg/day PO continuously
Study: NCT06533059

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALTA2618
Description: Oral ALTA2618 tablets will be administered at protocol-defined dose
Study: NCT05593445

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ruxolitinib cream
Description: Ruxolitinib cream is a topical formulation applied as a thin film to affected areas.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vehicle cream
Description: Vehicle cream is matching in appearance to ruxolitinib cream and is to be applied in the same manner as ruxolitinib cream.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Vehicle cream
Description: Vehicle cream is matching in appearance to ruxolitinib cream and is to be applied in the same manner as ruxolitinib cream.
Study: NCT06603987

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: BNCT
Description: Patients will be infused SPM-011 intravenously at a dose of 200mg/kg/hr over 2 hours. Thereafter, patient will be infused SPM-011 intravenously at a dose of 100mg/kg/hr and will receive neutron irradiation simultaneously for a certain period of time based on his Boronophenylalanine (BPA) concentration in the blood.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: ［18F］FBPA
Description: Intravenous injection of ［18F］FBPA and radiation exposure from PET-CT scan.
Study: NCT06598410

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Digital gaming
Description: Children in this group will be allowed to play digital games 5 minutes before the procedure starts. They will continue to play the game during the procedure.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: watching cartoon
Description: Children in this group will be shown a cartoon film 5 minutes before the procedure. They will continue to play the game during the procedure.
Study: NCT06610591

Intervention type: PROCEDURE
Intervention: Achilles Lengthening Surgery
Description: The procedure is undertaken under general anaesthetic and involves horizontal hemi-section of the Achilles tendon via small 'stab' incisions at three levels to effect a lengthening of the tendon. The patient is then placed in a walking cast for four weeks thereafter. This surgery is usual care for most children with symptomatic ITW with plantarflexion contractures who have failed non-operative management.
Study: NCT06610266

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Weifuchun
Description: Subjects will be instructed to take four tablets (1400mg) of Weifuchun three times daily, and visit the hospital every 4 weeks for evaluation of the subjective symptoms and to receive a new supply of medication.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Folic Acid
Description: Subjects will be instructed to take one tablet (5mg) of folic acid three times daily, and visit the hospital every 4 weeks for evaluation of the subjective symptoms and to receive a new supply of medication.
Study: NCT06611202

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise
Description: A multidisciplinary six-minute walking group intervention-spearheaded by physiotherapists, occupational therapists, and psychologists-in enhancing physical activity, mobility, cognitive function, and functional independence among patients with dementia.~Physiotherapy Component: A six-minute walking group will be conducted twice a week for 8 weeks, targeting improvements in mobility, endurance, and balance. Occupational Therapy Intervention: Occupational therapists will integrate functional tasks (Games and throwing of balls to court, bean bag target game to enhance exercise relevance to daily activities. A psychologist will provide mental health support during the sessions, utilising techniques like time focus reminiscence therapy to engage patients and reduce anxiety.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clonazepam
Description: Medication on our dementia wards are being review during ward round and when needs arise. The medication management in drugs will be fully documented and accounted for in the course of the study.
Study: NCT06623344

Intervention type: OTHER
Group type: OTHER
Intervention: Magnetic Resonance Imaging with or without Contrast
Description: Completion of Magnetic Resonance Imaging of the brain, heart, lungs, and liver with and without contrast.

Intervention type: OTHER
Group type: OTHER
Intervention: Magnetic Resonance Imaging with or without Contrast
Description: Completion of Magnetic Resonance Imaging of the brain, heart, lungs, and liver with and without contrast.
Study: NCT06623357

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pilot Training Protocol
Description: The pilot training protocol uses principles based on evidence-based research on factors that support caregiver learning of and adherence to home-therapy techniques/recommendations.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard Training Protocol
Description: The standard training protocol uses the caregiver training methods that are currently used in our clinics.
Study: NCT06692738

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rilvegostomig
Description: Administered intravenously (IV) on Day 1 of each 21-day cycle

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pembrolizumab
Description: Administered intravenously (IV) on Day 1 of each 21-day cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carboplatin
Description: Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Paclitaxel
Description: Administered intravenously (IV) on Day 1 of each 21-day cycle up to 4 cycles

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nab-paclitaxel
Description: Administered intravenously (IV) on Days 1, 8, and 15 of each 21-day cycle up to 4 cycles

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nab-paclitaxel
Description: Administered intravenously (IV) on Days 1, 8, and 15 of each 21-day cycle up to 4 cycles
Study: NCT06710886

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Listening to Calming Music
Description: Participants will listen to calming music, which may enhance health and wellness by reducing autonomic reactivity and improving bodily awareness, brain-body connection, and emotional wellbeing.
Study: NCT06728956

Intervention type: OTHER
Group type: OTHER
Intervention: READY for MS UK digital programme
Description: Online self-directed programme supported by HCPs
Study: NCT06729203

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ultrasound cavitation
Description: Ultrasound Fat Cavitation (USFC) is the method in handling obesity, especially in destroying fat and shaping a particular part of the body. As one of the non-surgical correction methods, USFC is preferred at decreasing the risk of complications due to obesity.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercise
Description: The female will stand on the cushioned tread and grasp by her both hands the two arms of the treadmill. Treadmill will adjust to apply moderate intensity training. It was used for 30 minutes divided into five-minutes warming up, twenty-minutes active exercise and five-minutes cooling down and it was used twice a week for twelve weeks.
Study: NCT06729736

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: ERAS protocol
Description: The ERAS protocol includes:~* Pre-admission education, counselling and nutritional support~* Pre-induction oral analgesics~* Minimal fasting and carbohydrate loading~* Omission of nasogastric intubation~* Intra-operative abdominal nerve block~* Early mobilization~* Early oral nutrition and minimal IV fluids~* Multimodal opioid sparing analgesia~* Postoperative nausea and vomiting prophylaxis~* Early removal of urinary catheters
Study: NCT06727682

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stress management
Description: Ten-hour, three-course stress management programme with a psychologist via video conferencing over a 2 month period. The classes will be delivered in small groups of maximum seven care workers. Carers can be brought together in the same room, but the speaker will necessarily be at a distance, via videoconferencing. The formation will adress the following issues: i) Understanding the mechanisms of stress, ii) Identifying sources of stress and triggers, iii) Anticipate stressful situations and use their resources to prevent them, and iv) Use the most appropriate stress-reduction techniques, depending on their sensitivity.
Study: NCT06728696

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Immediate implant with with dual zone technique using concentrated growth factor graft.
Description: In the test group, pouch technique + CGFG will be used. The CGFG will be packed in the split-thickness labial pouch between the labial bone plate and the overlying gingiva of the extraction socket. A convenient blood sample will be withdrawn from a peripheral venous blood from the patient using a specialized vacutaine. A standard, disposable, 10-ml non- anticoagulant tube and a matching centrifuge device was used. To prepare the CGFG, the centrifuge is accelerated for 30 seconds, then centrifuged at 2700 rpm for 2 minutes, 2400 rpm for 4 minutes, 2700 rpm for 4 minutes, and 3000 rpm for 3 minutes before being decelerated for 36 seconds to stop.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Immediate implant with dual zone technique using connective tissue graft.
Description: Patients assigned to the control group will receive pouch technique + CTG. Following implant placement, a split-thickness labial pouch between the labial bone plate and the overlying gingiva of the extraction socket will be performed using 15c mini blade to allow for the placement of a CTG. The pouch preparation will be extended apical beyond the muco-gingival junction and to the neighboring teeth mesiodistally. The CTG will be harvested from the palate with a thickness of 1.5 mm using single-incision technique, which was done approximately 2-3 mm apical to the gingival margin of the maxillary teeth and parallel to the palatal long axis. A resorbable suture will be used to first pierce the labial mucosa along with the periosteum at an apical part, which then exits from the sulcus. Afterward, the CTG will be tucked in the pouch, labial to the suture, and held at a coronal area by using the needle to pierce it from its inner surface toward the labial soft tissue. The knot will then be se