Study: NCT05887271

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Transthoracic echocardiography
Description: Comprehensive transthoracic echocardiography, including: tissue Doppler indices of diastolic filling and speckle tracking for systolic and diastolic strain/strain rate, exclusion of valvular abnormalities, assessment of LV size and function

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Transthoracic echocardiography
Description: Comprehensive transthoracic echocardiography, including: tissue Doppler indices of diastolic filling and speckle tracking for systolic and diastolic strain/strain rate, exclusion of valvular abnormalities, assessment of LV size and function

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Blood test
Description: Collection of blood samples from each participant to characterise the participant's health status and fibroinflammatory markers.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Blood test
Description: Collection of blood samples from each participant to characterise the participant's health status and fibroinflammatory markers.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Electrocardiogram
Description: An ECG will be obtained to assess for baseline rhythm.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Electrocardiogram
Description: An ECG will be obtained to assess for baseline rhythm.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Accelerometery
Description: Accelerometer (GeneActiv) measured daily activity levels continuously for 7 consecutive days.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Accelerometery
Description: Accelerometer (GeneActiv) measured daily activity levels continuously for 7 consecutive days.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: 6 minute walk test (6MWT)
Description: Supervised 6MWT will be performed with symptom assessment using dyspnoea scale (Borg's).

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: 6 minute walk test (6MWT)
Description: Supervised 6MWT will be performed with symptom assessment using dyspnoea scale (Borg's).

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Skeletal muscle strength using handgrip strength and quadriceps (Cybex dynamometer)
Description: Skeletal muscle strength will be measured using a cybex dynamometer.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Skeletal muscle strength using handgrip strength and quadriceps (Cybex dynamometer)
Description: Skeletal muscle strength will be measured using a cybex dynamometer.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Assessment of quality of life and heart failure symptoms
Description: Quality of life and HF symptoms will be assessed using the Minnesota Living with Heart Failure (MLWHF) questionnaire, which is used as a standardised measure of self-reported health status, and HF symptoms and is considered to have a good discriminatory power and validity

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Assessment of quality of life and heart failure symptoms
Description: Quality of life and HF symptoms will be assessed using the Minnesota Living with Heart Failure (MLWHF) questionnaire, which is used as a standardised measure of self-reported health status, and HF symptoms and is considered to have a good discriminatory power and validity

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Assessment of sarcopenia
Description: Participants will be assessed for presence of sarcopenia using the Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls (SARC-F) questionnaire. It is a robust tool for diagnosis of sarcopenia and prediction poor physical function, with excellent specificity in multimorbid individuals.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Assessment of sarcopenia
Description: Participants will be assessed for presence of sarcopenia using the Strength, Assistance with walking, Rise from a chair, Climb stairs and Falls (SARC-F) questionnaire. It is a robust tool for diagnosis of sarcopenia and prediction poor physical function, with excellent specificity in multimorbid individuals.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Assessment of frailty
Description: Frailty will be assessed using the Edmonton Frail Scale (EFS). The EFS is a multidimensional frailty assessment which assesses multiple domains of frailty including functional independence, social support, cognition, medication use, and mood.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Assessment of frailty
Description: Frailty will be assessed using the Edmonton Frail Scale (EFS). The EFS is a multidimensional frailty assessment which assesses multiple domains of frailty including functional independence, social support, cognition, medication use, and mood.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Qualitative interview
Description: Participants in the MRP and control groups will be invited to attend a focused semi-structured, 1-2-1 interview aimed to elicit barriers and enablers to the MRP and describe their perspective on the relationship between healthy eating and health interview during the 12-week visit. Participants who complete or drop out will be eligible. Inclusion of participants in the control arm will allow us to compare the experiences of MRP versus health coaching and detect any specific issues people face when trying to introduce lifestyle changes themselves.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Qualitative interview
Description: Participants in the MRP and control groups will be invited to attend a focused semi-structured, 1-2-1 interview aimed to elicit barriers and enablers to the MRP and describe their perspective on the relationship between healthy eating and health interview during the 12-week visit. Participants who complete or drop out will be eligible. Inclusion of participants in the control arm will allow us to compare the experiences of MRP versus health coaching and detect any specific issues people face when trying to introduce lifestyle changes themselves.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Skeletal muscle magnetic resonance spectroscopy
Description: Assessment of skeletal muscle volume (quadriceps and calf muscle) using MRI, and 31P-magnetic resonance spectroscopy (31P-MRS) of the skeletal muscle using fysiometer and during isometric exercise at rest and after 5 minutes of exercise to assess changes in muscle energetics at rest and on exercise.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Skeletal muscle magnetic resonance spectroscopy
Description: Assessment of skeletal muscle volume (quadriceps and calf muscle) using MRI, and 31P-magnetic resonance spectroscopy (31P-MRS) of the skeletal muscle using fysiometer and during isometric exercise at rest and after 5 minutes of exercise to assess changes in muscle energetics at rest and on exercise.