TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05214391

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Zanubrutinib
Description: The initial dose is 80mg/day. If the treatment is ineffective after 4 weeks, and under the condition of good safety, the investigator will judge that the dosage should be added to 80mg twice/day，or a higher dose for oral maintenance. The maximum dose is 160mg twice a day. The duration of zanubrutinib is 24 weeks.~In case of intolerable adverse reactions, such as severe infection, severe bleeding, hematopenia, arrhythmia, etc., investigator can reduce the dose of zanubrutinib, or withdraw from clinical trials as appropriate.
Study: NCT06277232

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: activity training (part of Interdisciplinary Pain Rehabilitation Program)
Description: Activity training includes graded activity training, and exposure training, which are delivered by an interdisciplinary team (i.e., a physiotherapist, an occupational therapist, and a psychologist).

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: meetings (part of Interdisciplinary Pain Rehabilitation Program)
Description: The meetings consist of conferences with patients, rehabilitation team, vocational guidance, rehabilitation coordinator, goal-setting meetings, and meetings to check goal achievement.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Cognitive behavioral therapy (part of Interdisciplinary Pain Rehabilitation Program)
Description: Acceptance and Commitment Therapy (ACT, e.g., goal compass, training in ACT principles, and mindfulness) is mainly delivered by psychologist in a group-treatment (e.g., training in coping strategies). The cognitive behavioral principles are also used in physiotherapy, ergonomics, and education in pain management.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Relaxation techniques (part of Interdisciplinary Pain Rehabilitation Program)
Description: This group-treatment is mainly format by a physiotherapist and psychologist in an interdisciplinary team.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Physical exercise (part of Interdisciplinary Pain Rehabilitation Program)
Description: This group-treatment is mainly format by a physiotherapist in an interdisciplinary team.
Study: NCT05148416

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: High intensity laser treatment
Description: 20 patients received high power laser therapy . Zimmer High power laser applied by laser probe perpendicular to and in slight contact with the skin around knee joint , the total energy was delivered to the patient during one session was 1060 j in 3 phases of treatment.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: sham HILT.
Description: 20 patients received placebo laser  sham laser . The same treatment protocol of HILT was given to the sham group, but the laser instrument was switched off during applications. All laser applications were performed by the same physiotherapist.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: knee osteoarthritis conventional exercises program
Description: knee osteoarthritis conventional exercises program in form of stretching exercises for both vastus medialis and gastrocnemius muscles , ROM exercises for knee flexion and extension , and isometric strengthening exercise of previously mentioned muscles .~all interventions were done under the supervision of physiotherapist for 30 minutes once a day for 3 days per week during a period of 4 weeks.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: knee osteoarthritis conventional exercises program
Description: knee osteoarthritis conventional exercises program in form of stretching exercises for both vastus medialis and gastrocnemius muscles , ROM exercises for knee flexion and extension , and isometric strengthening exercise of previously mentioned muscles .~all interventions were done under the supervision of physiotherapist for 30 minutes once a day for 3 days per week during a period of 4 weeks.
Study: NCT06461052

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: music therapy
Description: The patient will benefit from viewing the video and the music therapy session in the waiting room of the operating room. The patient will be asked again for their anxiety score using an anxiety scale. This will define the main outcome of the study. Following this collection and in order not to influence the response, investigators will collect from the patient his compliance with the two proposed techniques as well as his appreciation of the tool.
Study: NCT06294964

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: sleep education, behavioral education
Description: Provide health education materials which covering sleep education, behavioral education, chronic diseases such as cardiovascular diseases. Topics touch on such as why you need healthy sleep? What methods can be used to regulate insomnia, and how to regulate sleep breathing problems? How do the elderly maintain a good sleep? What are the risk factors for cardiovascular and cerebrovascular diseases? How to reduce the risk of developing sleep disorders or chronic diseases through changing everyday life?
Study: NCT05927259

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: n acetyl cysteine
Description: A patients received NAC 140 mg/Kg IV infusion (as a loading dose), then 70 mg/KgIV infusion every 4 hours up to 17 doses

Intervention type: DRUG
Group type: OTHER
Intervention: standard treatment
Description: stabilization and antidotes

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: standard treatment
Description: stabilization and antidotes
Study: NCT04905095

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: EWS
Description: Early Warning Score will be implemented in the computer system of the nursing station which belong to this intervention group. When the nurses enter the vital signs of the patients into the system, the EWS will be automatically calculated and an alarm will be displayed if an intervention is necessary, which is protocolized.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: usual clinical care
Description: Nurses perform their clinical monitoring activities as usual. EWS will not be implemented in their nursing station
Study: NCT06600269

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Cycling Training
Description: Cycling combined with priming strategies to enhance motor learning tasks. Each session will last for 15 minutes, conducted three times per week, over a period of two weeks.
Study: NCT05775315

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Action Observation Therapy
Description: Exercises of AO protocol MOVEMENT TOTAL VIDEO TIME PATIENT TIME Upright the pelvis 1 minute 5 minutes Move weight forward 1 minute 5 minutes Move weight to the left and right 1 minute 5 minutes Rotate right and left 1 minute 5 minutes Upright the pelvis in sitting position 1 minute 5 minutes Move weight forward from a sitting position 1 minute 5 minutes Stand up from a sitting position 1 minute 5 minutes Move weight right and left 1 minute 5 minutes Forward weight shift with right foot and left foot 1 minute 5 minutes Walking sideways to left 1 minute 5 minutes Walking sideways to right 1 minute 5 minutes~Rest time between watching and performing each video will be 1 minute. the exercises will be done 3 times a week.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Action Observation Therapy along with visual feedback
Description: Exercises of AO protocol in front of a mirror MOVEMENT TOTAL VIDEO TIME PATIENT TIME Upright the pelvis 1 minute 5 minutes Move weight forward 1 minute 5 minutes Move weight to the left and right 1 minute 5 minutes Rotate right and left 1 minute 5 minutes Upright the pelvis in sitting position 1 minute 5 minutes Move weight forward from a sitting position 1 minute 5 minutes Stand up from a sitting position 1 minute 5 minutes Move weight right and left 1 minute 5 minutes Forward weight shift with right foot and left foot 1 minute 5 minutes Walking sideways to left 1 minute 5 minutes Walking sideways to right 1 minute 5 minutes~Rest time between watching and performing each video will be 1 minute. the exercises will be done 3 times a week.
Study: NCT05507515

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets
Study: NCT04953221

Intervention type: DRUG
Intervention: YJ001
Description: Skin spray

Intervention type: DRUG
Intervention: YJ001
Description: Skin spray

Intervention type: DRUG
Intervention: YJ001
Description: Skin spray
Study: NCT05710549

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: high-density electroencephalography (hdEEG)
Description: EEG will be recorded with a 257-channel EEG system (Geodesic Sensor Net, MegStim). An EEG net is applied at once on the head with evenly spaced sensors that provide full scalp coverage, including the cheek, Ag/Ag-Cl electrodes that are interconnected by thin rubber bands and contain small sponges soaked with saline water that touches the participant's scalp surface directly. Net application takes about 10 min to derive impedances to \<30 kOhms. EEG is recorded with 1 kHz and band-pass filtered between 0.1-200 Hz. Vertex electrode Cz is used as an acquisition reference.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial alternating current stimulation (tACS)
Description: tACS will be delivered by a battery-driven current stimulator Starstim SS32 (Neuroelectrics) through surface Ag/AgCl electrodes placed into holes of a neoprene cap corresponding to the international 10/20 EEG system. Gel (Parker Lab, Inc.) will be applied to optimize signal conductivity and lower impedance.
Study: NCT05507515

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets
Study: NCT05589337

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Baduanjin
Description: The Baduanjin training program consisted of two 90-min training classes and at least five 30-min at-home practice sessions per week for 16-weeks. All sessions included 10 min of warmup and 10 min of cooldown.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health education
Description: Health education is provided by psychologist and TCM doctor, including work, rest, diet and other basic programs.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Health education
Description: Health education is provided by psychologist and TCM doctor, including work, rest, diet and other basic programs.
Study: NCT05507515

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ONO-2020
Description: ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets
Study: NCT05516849

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oxandrolone
Description: Oxandrolone is a synthetic anabolic androgenic steroid that induces its responses by binding to androgen receptors which modulates gene expression to increase protein synthesis and efficient utilisation of amino acids. Oxandrolone was first synthesized in 1962 through 17alpha-alkylation of testosterone resulting in a formal composition of (4bS,7S,9aS,9bR,11aS)-tetradecahydro-7-hydroxy-4aS,6aS,7-trimethyl- cyclopentanaphthopyran-2(1H)-one and molecular formula of C19H30O3.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: As there is currently no approved medication to aid in soft-tissue regeneration, we will be using a placebo control.
Study: NCT05507515

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Placebo tablets matching ONO-2020 tablets
Study: NCT05486689

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pulmonary Rehabilitation
Description: The enrolled subjects will receivePR program. The 3 weeks inpatient PR will include education, exercise training, nutritional and psychological counselling.~Education: individualized session of 20 minutes each and group session of 45 minutes each. Endurance training: at least twelve 30-minute daily sessions of supervised incremental exercise training according to Maltais, continuous cycling at 50-70% of the maximal load calculated on the basis of the baseline 6MWT according to Hill. Strength training: twelve 30-minute daily sessions of peripheral limb muscle strength training: 2 set of 8 repetitions during the first week, increased at 12 from the second. The initial load will be set at 30/50% of maximal voluntary isometric strength (MVS). Psychological intervention: individual tailored intervention will be offered when the Hospital Anxiety and Depression Scale (HADS) score is \>10 or judged necessary by clinicians, after verifying the subject's motivation.
Study: NCT04765306

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Traditional Direct Fascial Closure
Description: Fascial closure using traditional surgical instruments and suture without laparoscopic guidance.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Fascial Closure Device
Description: Fascial closure using a fascial closure device under direct laparoscopic guidance.
Study: NCT05189535

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pentoxifylline
Description: Pentoxifylline 400 mg oral tablet twice daily for 12 weeks.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Paclitaxel
Description: Paclitaxel I.V 80 mg/m2 weekly

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: Paclitaxel I.V 80 mg/m2 weekly

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo
Study: NCT05920109

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: ESP block
Description: Patients in the experimental group will have a continuous Erector Spinae Plane Block within the first 6 hours post-admission, with a continuous 1ml/h infusion of Ropivacaine (2mg/ml) associated with a 25 ml bolus every 6h. The catheter will be used from the trauma bay to the ICU as long as possible with a dedicated infusion pump (with a bolus mode). In case of accidental catheter removal, a second introduction of ESP block catheter is allowed within the first 24 hours. In case of continuous ESP block failure (incidence \< 5% of the total experimental group), patients will be switched to the control group.
Study: NCT05103891

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Binimetinib Oral Tablet
Description: two-period, crossover study

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Binimetinib Oral Tablet
Description: two-period, crossover study
Study: NCT05647759

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: HEART Camp Connect
Description: Once eligible and enrolled, participants will aim to complete 150 minutes of moderate-intensity exercise a week with the help of a virtual exercise coach
Study: NCT06269029

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Chest mobility exercises
Description: exercises were repeated 6 times on each side with rest of period for 30 seconds in between. The intervention will be carried out for one week with total of 7 sessions. Each Exercise will be accompanied by breathing pattern. In neutral position of exercises, subjects will be asked to exhale during flexion, turning or extension subject will be asked to do inhale.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: proprioceptive neuromuscular facilitation
Description: The technique used in this study Proprioceptive neuromuscular facilitation technique of hold and relax stretching for isolated clavicular head of the pectoralis major muscle. The subjects sitting on a chair with back support to keep spine in a neutral position and both their arms are extended and hands are placed behind the occipital region. His both arms will be positioned in glenohumeral horizontal extension, and glenohumeral abduction and external rotation with elbow bent to perform stretch position of pectoral muscle. Then ask him to contract the pectoral muscles .This isometric contraction is held for 6 seconds. The patient then relaxed and passive stretch in the opposite direction . and it was repeated 6 times with rest period 30 seconds. The session will be given every day for one week
Study: NCT05300672

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: fibrinogen infusion
Description: fibrinogen infusion (2 g) in stroke patients with secondary post-rtPA hypofibrinogenemia
Study: NCT04905784

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Differential learning
Description: The patient will be requested to perform different exercises, each exercise one time a day for 3 days in a row before moving to the next exercise. All patient will be asked to do the exercises in the same sequence.
Study: NCT05799989

Intervention type: PROCEDURE
Intervention: Surgical fixation
Description: Pediatric patients with intravenous and/or intraarterial catheter in situ secured with surgical fixation

Intervention type: PROCEDURE
Intervention: Atraumatic fixation
Description: Pediatric patients with intravenous and/or intraarterial catheter in situ secured with atraumatic fixation
Study: NCT04826770

Intervention type: DRUG
Intervention: BNT162b2
Description: vaccination against COVID-19

Intervention type: DRUG
Intervention: BNT162b2
Description: vaccination against COVID-19

Intervention type: DRUG
Intervention: BNT162b2
Description: vaccination against COVID-19

Intervention type: DRUG
Intervention: BNT162b2
Description: vaccination against COVID-19
Study: NCT04905784

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Usual toothbrushing
Description: The patients in this group will be provided with the regular oral health instructions, including the traditional toothbrushing recommendations.
Study: NCT04304911

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Blended intervention (UP-APP)
Description: Unified Protocol (UP) for transdiagnostic treatment of EDs in the blended intervention (UP-APP)

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Behavioral Therapy (TAU)
Description: TAU group that carries out Cognitive Behavioral Therapy in an individual format
Study: NCT06589505

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Software as a Medical Device
Description: The subject will undergo treatment using the Software as a Medical Device
Study: NCT06317298

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fruquintinib and Everolimus
Description: Fruquintinib and Everolimus

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fruquintinib and Everolimus
Description: Fruquintinib and Everolimus

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fruquintinib and Everolimus
Description: Fruquintinib and Everolimus
Study: NCT05570747

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Eclipse novel CPAP mask
Description: Participants will follow instructions to set up and put on the Eclipse nasal mask. The Eclipse removes the headgear associated with traditional CPAP masks, offering a small compact design weighing less than an ounce. The Eclipse uses small and lightweight adhesive seals around the nostrils to create an ergonomic design which accommodates the shape of each individual user. It completes a perfect circuit for CPAP therapy to deliver pressure to the airway and stabilize the user's disordered breathing during sleep (apnea and snoring).~Participants will follow instructions to set up and put on the mask. They will fill out a survey about the ease and comfort of putting on and wearing the mask, briefly.
Study: NCT06131944

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Rested & Ready to Learn
Description: The intervention arm targets improving young children's sleep by providing parents with sleep education and activities to do at home with their child. Classroom teachers will also deliver a brief lesson aligned with intervention topics to reinforce key messaging in the classroom. The sleep intervention will focus on the benefits of sleep (physical health, social-emotional health, classroom participation/learning), creating and sticking to a bedtime routine, screen use before bed, and developmentally appropriate sleep behavior.
Study: NCT05570747

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Phillips Respironics Nuance
Description: Participants will follow instructions to set up and put on the Respironics Nuance, traditional nasal mask. Participants will follow instructions to set up and put on the mask. They will fill out a survey about the ease and comfort of putting on and wearing the mask, briefly.