TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04922502

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Standard SPACE
Description: 12 one hour parent sessions over 12 weeks in which the therapist guides the parent to target anxious behaviors and support adaptive child behaviors.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Bibliotherapy, low therapist contact SPACE
Description: 4 one hour parent sessions over 12 weeks in which the therapist supports the parent in understanding and implementing content reviewed in the book Breaking Free of Child Anxiety and OCD.
Study: NCT04338152

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Family Focused Therapy for Clinical High Risk Youth (FFT-CHR)
Description: Family-Focused Therapy (FFT) has been tested in randomized trials involving persons with bipolar disorder, depression, and clinical high-risk syndromes. FFT-CHR provides families with psychoeducation (sessions 1-6) about prodromal symptoms and the role of the family in helping maintain stability. Clients are supported in building coping skills and monitoring thoughts, perceptions, and mood. The family formulates a prevention action plan to prevent prodromal symptoms from escalating into full episodes. Communication training (sessions 7-13) teaches families to express positive and negative feelings, listen actively, make positive requests for change, and communicate clearly through role-playing and between-session practice. In problem solving (sessions 14-18) participants learn to break down problems into smaller ones, evaluate pros/cons, and choose solutions to implement.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Enhanced Care (EC)
Description: Enhanced care (EC) has been tested as a family educational treatment in CHR and bipolar youth. The first 3 sessions of EC involve the CHR person and family (parents, siblings) and cover the same content as the psychoeducational module of FFT in abridged form. The objective of these sessions is to develop a prevention action plan. Then, the CHR person is offered monthly individual sessions with the same clinician over the next 5 months, for a total of 8 sessions over 6 months. The individual sessions focus on applying the prevention action plan when symptoms emerge, and supportive, nondirective problem-solving regarding areas of conflict with family, with peers or in the educational or occupational arena. The clinician also serves as case manager.
Study: NCT04761458

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Olfactory function testing
Description: Olfactory function will be evaluated through the Burghart Sniffin' Sticks test which is a validated psychophysical testing method. Sniffin' Sticks test is based on pen-like odor dispensing devices that will be presented to the patients. The extended version of this test will be used and consist of three tests of olfactory function, namely tests for odor threshold, odor discrimination and odor identification.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Edmonton Frail Scale
Description: The Edmonton Frail Scale (EFS) involves nine domains of frailty : functional performance, cognitive function, general health, functional independence, social support, used medications, nutrition, mood and continence. It has been validated with respect to comprehensive geriatric assessment and to other screening tools related to frail state. EFS test is considered most appropriate for use in routine preoperative screening and only requires 5 minutes.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Clinical Frailty Scale
Description: The Clinical Frailty Scale (CFS) uses clinicians' judgement to evaluate frailty. It comprises assessment of specific domains including comorbidity, function, and cognition. Score ranges from 1 (very fit) to 9 (terminally ill).

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Neuropsychological test battery
Description: Patients will undergo a neuropsychological test battery preoperatively and postoperatively. This test consists of a battery of psychometric assessments with the ability to objectively assess specific cognitive domains such as attention, executive function, learning and memory, language, perceptual-motor, or social cognition.
Study: NCT06107933

Intervention type: OTHER
Intervention: Observational only
Description: Exposure to micro and nano plastics

Intervention type: OTHER
Intervention: Observational only
Description: Exposure to micro and nano plastics
Study: NCT06637501

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sonrotoclax
Description: Administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Zanubrutinib
Description: Administered orally

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Zanubrutinib
Description: Administered orally
Study: NCT05052723

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cabozantinib
Description: Cabozantinib (XL184) is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) known to play important roles in tumor cell proliferation and/or tumor neovascularization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Pembrolizumab is a potent humanized immunoglobulin G4 (IgG4) monoclonal antibody (mAb) with high specificity of binding to the programmed cell death 1 (PD-1) receptor, thus inhibiting its interaction with programmed cell death ligand 1 (PD-L1) and programmed cell death ligand 2 (PD-L2).
Study: NCT05191472

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Given IV
Study: NCT06242821

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard of Care (SOC)
Description: Patients will continue with their current standard of care treatment.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard of Care (SOC)
Description: Patients will continue with their current standard of care treatment.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Yoga
Description: Patients will be randomized to participate in the Yoga intervention. This will consist of online 20 min yoga classes, 2 times per week. The class will be a set protocol, and patients will be given the protocol to do at home if desired.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Yoga
Description: Patients will be randomized to participate in the Yoga intervention. This will consist of online 20 min yoga classes, 2 times per week. The class will be a set protocol, and patients will be given the protocol to do at home if desired.
Study: NCT06635720

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: This study will compare two steroid dosing protocols for the treatment of childhood nephrotic syndrome relapses. The medications used for both intervention and control arms are oral prednisone 5mg tablets (DIN: 00312770) for children able to swallow or use crushed tablets, or oral prednisolone sodium phosphate 5mg base/5mL liquid (DIN: 02245532). Participants hospitalized after study enrollment will be permitted to switch to intravenous methylprednisolone sodium succinate (DIN: 02367955) at the same dose without being considered to have violated their treatment assignment.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Prednisone
Description: This study will compare two steroid dosing protocols for the treatment of childhood nephrotic syndrome relapses. The medications used for both intervention and control arms are oral prednisone 5mg tablets (DIN: 00312770) for children able to swallow or use crushed tablets, or oral prednisolone sodium phosphate 5mg base/5mL liquid (DIN: 02245532). Participants hospitalized after study enrollment will be permitted to switch to intravenous methylprednisolone sodium succinate (DIN: 02367955) at the same dose without being considered to have violated their treatment assignment.
Study: NCT06634706

Intervention type: DEVICE
Group type: OTHER
Intervention: RefleXion X1 Radiotherapy System [Imaging Only]
Description: kVCT and FDG-PET imaging using the RefleXion X1 Radiotherapy System in different anatomical regions

Intervention type: DEVICE
Group type: OTHER
Intervention: RefleXion X1 Radiotherapy System [Imaging Only]
Description: kVCT and FDG-PET imaging using the RefleXion X1 Radiotherapy System in different anatomical regions

Intervention type: DEVICE
Group type: OTHER
Intervention: RefleXion X1 Radiotherapy System [Imaging Only]
Description: kVCT and FDG-PET imaging using the RefleXion X1 Radiotherapy System in different anatomical regions

Intervention type: DEVICE
Group type: OTHER
Intervention: RefleXion X1 Radiotherapy System [Imaging Only]
Description: kVCT and FDG-PET imaging using the RefleXion X1 Radiotherapy System in different anatomical regions

Intervention type: DEVICE
Group type: OTHER
Intervention: RefleXion X1 Radiotherapy System [Imaging Only]
Description: kVCT and FDG-PET imaging using the RefleXion X1 Radiotherapy System in different anatomical regions

Intervention type: DEVICE
Group type: OTHER
Intervention: RefleXion X1 Radiotherapy System [Imaging Only]
Description: kVCT and FDG-PET imaging using the RefleXion X1 Radiotherapy System in different anatomical regions
Study: NCT06634979

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Selective lymph node dissection
Description: For 0.5 \< CTR \< 1 and ≤ 2 cm diameter cT1N0M0 invasive non-small cell lung cancer patient sex for selective lymph node (lower mediastinal lymph nodes are not required to be cleared for upper lobe tumors and upper mediastinal lymph nodes are not required to be cleared for lower lobe tumors)
Study: NCT06634472

Intervention type: OTHER
Intervention: AI
Description: AI-enabled skin perforator segmentation tool
Study: NCT06635265

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Target Stimulation (HGN, AC, GG, Strap muscles)
Description: Simulation of a combination of: HGN, AC, GG or strap muscles
Study: NCT06635330

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: anti-CD19 CAR T cell therapy
Description: Anti-CD19 CAR-T cell therapy for R/R B-ALL pediatric patients. For patients 50 kg and less: 0.2 to 5 in ten to the power of six live CAR+ T cells per kilogram of body weight/ For patients over 50 kg: 0.1 to 2.5 in ten to the power of eight live CAR+ T cells (without considering weight).
Study: NCT05645588

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Pranayama assisted trauma-focused standard psychotherapy (TF-SPT)
Description: To prepare patients for the TF-SPT, they received 5-10 minutes of pranayama at the begin of each of the 10 TF-SPT units.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Trauma-focused standard psychotherapy (TF-SPT)
Description: Patients wait for 10 TF-SPT units and then are offered to learn pranayama
Study: NCT05700682

Intervention type: DEVICE
Intervention: Shoulder/Hip/Knee Embolization with Embozene Microspheres
Description: Fluoroscopically-guided arterial embolization of synovitis in the painful shoulder, hip or knee.
Study: NCT06577532

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ABO2102
Description: mRNA encoding mutant KRAS neoantigens, administrated intramuscularly

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ABO2102
Description: mRNA encoding mutant KRAS neoantigens, administrated intramuscularly

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab
Description: Anti-PD-1 antibody, administered intravenously
Study: NCT06167681

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Human Dopaminergic Progenitor Cells
Description: Single injection of Human Dopaminergic Progenitor Cells into the putamen/striatum region of brain.
Study: NCT04298541

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ga-68- DOTATATE
Description: The study intervention consists of two PET scans that will be performed using two different radiotracers, 68-Ga-DOTATATE and 68-Ga-DOTATOC. Ga-68-DOTATATE and 68-Ga-DOTATOC are PET radiotracers targeting somatostatin receptors.~The study intervention consists of 2 PET scans that will be performed at least 24h apart using 68-Ga-DOTATATE and 68-Ga-DOTATOC radiotracers, in patients with suspected meningioma that are planned for subsequent surgery.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ga-68-DOTATOC
Description: The study intervention consists of two PET scans that will be performed using two different radiotracers, 68-Ga-DOTATATE and 68-Ga-DOTATOC. Ga-68-DOTATATE and 68-Ga-DOTATOC are PET radiotracers targeting somatostatin receptors.~The study intervention consists of 2 PET scans that will be performed at least 24h apart using 68-Ga-DOTATATE and 68-Ga-DOTATOC radiotracers, in patients with suspected meningioma that are planned for subsequent surgery.
Study: NCT04740294

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Magnesium Sulfate
Description: Randomized to receive either magnesium sulfate or normal saline placebo.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Magnesium Sulfate
Description: Randomized to receive either magnesium sulfate or normal saline placebo.
Study: NCT04842955

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Gamma tACS (40 Hz) over the superior parietal cortex
Description: Single session of gamma tACS (40 Hz) over the superior parietal cortex

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham tACS over the superior parietal cortex
Description: Single session of sham tACS over the superior parietal cortex
Study: NCT05985486

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Diet
Description: A reduced calorie diet which uses frozen meals purchased at the store and focuses on increasing fruits and vegetables associated with brain health.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Health Education
Description: Monthly health education sessions delivered remotely.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health Education
Description: Monthly health education sessions delivered remotely.
Study: NCT05284994

Intervention type: DRUG
Group type: OTHER
Intervention: TQ-B3525 Tablets, Osimertinib Mesylate Tablets
Description: TQ-B3525 is a novel α/δ dual inhibitor PI3K kinase inhibitor. Osimertinib mesylate is a third-generation epidermal growth factor receptor inhibitor.
Study: NCT04947111

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Estimate the distribution of antibodies by serotype by Dengue virus in areas of low and high incidence of dengue
Description: Indirect IgG ELISA to estimate seroprevalence: The seropositivity will be evaluated with the Indirect IgG ELISA following the instructions of the Panbio E-DEN 01 G manufacturer, which has a specificity of 98% and a sensitivity of 100%. In brief, 10 microliters of participant serum will be used for each assay. Each kit provides a positive and negative control, as well as three calibrators, with the respective values for quality control. Samples will be classified as positive, negative or indeterminate according to the cut-off point for each ELISA kit.~Neutralizing antibody titers serotype-specific: To establish the type of humoral immunity that the selected city presents, the measurement of the neutralizing antibody titers will be carried out by means of the neutralization test by reducing the number of lytic plaques to 50% (PRNT50%) , using Vero cells and the following reference strains for each serotype: DENV-1 (HAWAI), DENV-2 (NEW GUINEA), DENV-3 (H-887) and DENV-4 (H-24)
Study: NCT04838301

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Allopregnanolone
Description: Allopregnanolone 4mg IV via 30-minute infusion, once per week.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Normal saline solution IV via 30-minute infusion, once per week
Study: NCT06464393

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ketamine-lidocaine-dexmedetomidine
Description: Patients will be administered 0,8 mcg/kg Dexmedetomidine in 100 mL of normal saline within 10 minutes as premedication. Followingly, they will receive 1mL/10 kg of the solution containing ketamine, lidocaine and dexmedetomidine at predefined concentrations just before induction of anesthesia.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: fentanyl
Description: Patients will be administered 2 mcg/kg fentanyl in 100 mL of normal saline within 10 minutes as premedication. Followingly, they will receive 1mL/10 kg of normal saline solution 0.9% just before induction of anesthesia.
Study: NCT05852171

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib
Description: Baricitinib administered orally
Study: NCT06585475

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Structured training according to premenstrual syndrome symptom map
Description: A symptom map consisting of evidence-based practices for coping with PMS symptoms was created. An educational content based on this map was prepared and applied to women with PMS to evaluate whether it was effective compared to the control group.
Study: NCT04837248

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Active Comparator: Group 1. Conventional treatment
Description: Patients will be treated using a physiotherapy programme without digital support. A written document with exercises and recommendations will be given to them on the first day. This booklet will detail the exercises they can do depending on their surgery and the weeks elapsed, as well as the recommendations adapted according to the needs identified in the motivational interview (MI). This is the treatment that is currently being applied in the hospital.~The patient will carry out the treatment at home and will come back after 20 sessions for the corresponding assessment.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental: Group 2. Experimental treatment.
Description: A digitally supported physiotherapy programme including:~* Group session: expectations, interests, experiences with regard to their health problem and the consequences on their life, joint exercise and discussion with subsequent debate will be held.~* Exercise session: each week, patients will find different exercise videos on the platform according to the phase of recovery in which each one of them is, having been previously evaluated in the group session.~* Relaxation session: this will be carried out by means of audio that will be posted on the platform and that the patient will be able to perform simultaneously.~* Empowerment session: audio sessions that will deal with those needs that frequently arise after breast surgery in their daily lives, focusing on limiting beliefs (e.g. fear of moving), positive thoughts and information extracted from the motivational interview that should be developed.
Study: NCT05221164

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aspirin 162 mg
Description: Daily aspirin 162 mg during pregnancy to prevent preeclampsia
Study: NCT04236557

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Music listening
Description: Other than usual care, subjects will listen to a 30-min individualized playlists with preferred music genres sequenced by a registered music therapist according to the ISO-Principle when agitated.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Audio Book Listening
Description: Other than usual care, subjects will listen to to a 30-min audio-script of book reading in Cantonese (a common dialect in Hong Kong being spoken by most people) when agitated.
Study: NCT05649904

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: IRRAflow with Active Fluid Exchange System
Description: IRRAflow® Active Fluid Exchange System is an intracranial drainage system intended for use by professional medical hospital personnel, trained and experienced in neurosurgical medical care.~The intracranial pressure is kept at a safe level by draining excessive intracranial fluid. The system incorporates an irrigation support mechanism, used to irrigate the system in a controlled, programmed manner to minimize catheter occlusion. Additionally, a manual bolus can be given to facilitate keeping the catheter clear of occlusion or to clear the catheter of occlusion if one is present. This mechanism works by producing a bolus pulse using short periods of high flow (i.e. flow pulses).

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: External Ventricular Drain
Description: The External Ventricular Drain (EVD) is used standard of care at the study site for ventricular drainage.
Study: NCT04749771

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Filming Interactions to Nurture Development
Description: FIND is a brief video coaching intervention which involves feedback provided by the coach to the caregiver using brief film clips derived from video of caregiver-child interaction collected in the home.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: The Healthy Toddler Program
Description: HTP, the active control intervention, consists of weekly sessions alternating between (a) coaching sessions covering one of five domains of child development (Motor, Cognitive, Language, Play, and Social-Emotional and (b) observation sessions that will include a review of the prior coaching session and an observation and discussion of the caregiver-child interaction.
Study: NCT05621720

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Case management
Description: On enrolment, the nurse case manager will perform the initial comprehensive assessment based on the Omaha domains of environment, psychosocial, physiological and health-related behavior. The nurse case manager will execute the intervention scheme of teaching, guidance \& counseling, treatments \& procedure, case management, and/or surveillance, with the mutual goal set with clients to promote health and self-efficacy. Home visits and telephone calls will be employed. The referral network to health and social service will be activated as appropriate.

Intervention type: OTHER
Group type: OTHER
Intervention: Social control call and usual are
Description: Subjects in the control group will receive usual community service. in addition, a monthly social control call from trained community workers will be given to rule out the possible social effects of the intervention. These social calls will not be related the participants' health condition nor delivery of any health information.
Study: NCT06516692

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Inferior Vena Cava Collapsibility/distensibility Index (IVC CI/DI) assessment
Description: Assessment of hydration status in critically ill patient recruited to this arm will be intervened through an ultrasound guided calculation of collapsibility and distensibility index of Inferior Vena Cava. This method of intervention will be continued and repeated as needed throughout the stay of the participant in intensive care unit.
Study: NCT05899868

Intervention type: DEVICE
Group type: OTHER
Intervention: Time to Intubation using FASTER device
Description: Time from fiberoptic placement onto airway to documentation of end-tidal carbon dioxide waveform through the endotracheal tube.