Study: NCT04442061

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transcranial magnetic stimulation
Description: Before the stimulation, identification of a motor hotspot and active motor threshold (AMT) will be performed. The TMS will be applied on the intermittent theta-burst modality (iTBS), i. e., 2 s of TBS trains (30 pulses) repeated every 10 s for 190 s, with a total number of 600 pulses (Huang et al, 2005). The whole TMS session, including preparation, will last up to 1h.~The sham TMS follows the same procedure of the active TMS without stimulating cortical tissue

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcranial magnetic stimulation
Description: Before the stimulation, identification of a motor hotspot and active motor threshold (AMT) will be performed. The TMS will be applied on the intermittent theta-burst modality (iTBS), i. e., 2 s of TBS trains (30 pulses) repeated every 10 s for 190 s, with a total number of 600 pulses (Huang et al, 2005). The whole TMS session, including preparation, will last up to 1h.~The sham TMS follows the same procedure of the active TMS without stimulating cortical tissue

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: MRI
Description: Anatomical and functional images will be acquired and review by an experienced neuro-radiologist.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: MRI
Description: Anatomical and functional images will be acquired and review by an experienced neuro-radiologist.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Neuronavigation
Description: The neuronavigation system will allow to guide the stimulation using the individual anatomical MRI acquired with MRI, and to record the position and orientation of the coil during successive stimulations

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Neuronavigation
Description: The neuronavigation system will allow to guide the stimulation using the individual anatomical MRI acquired with MRI, and to record the position and orientation of the coil during successive stimulations

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Eye-tracking
Description: Eye movements and follow a person's gaze will be recorded during visualization of stimuli presented in the screen by analyzing images of the eye captured by an infrared camera

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Eye-tracking
Description: Eye movements and follow a person's gaze will be recorded during visualization of stimuli presented in the screen by analyzing images of the eye captured by an infrared camera

Intervention type: GENETIC
Group type: ACTIVE_COMPARATOR
Intervention: Salivary samples
Description: The DNA will be extracted from the salivary sample to genotyping analyses on the BDNF (Val66Met) and COMT (Val158Met) polymorphism

Intervention type: GENETIC
Group type: SHAM_COMPARATOR
Intervention: Salivary samples
Description: The DNA will be extracted from the salivary sample to genotyping analyses on the BDNF (Val66Met) and COMT (Val158Met) polymorphism

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Clinical scales
Description: CGI, E-CAR and ABC will be used for behavior and clinical evaluation

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Clinical scales
Description: CGI, E-CAR and ABC will be used for behavior and clinical evaluation