TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06354361

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Trauma-Informed Goal Management Training (TI-GMT)
Description: Trauma Informed-Goal Management Training (TI-GMT) is a modified version of Goal Management Training (GMT), a cognitive remediation program that emphasises mindfulness and practice in planning and completing goal-oriented behaviours. TI-GMT enhances the standard GMT protocol with the addition of several trauma-informed adaptations and content that is sensitive and specific to public safety personnel with PTSD.~Participants are trained to interrupt ongoing disruptive behaviours through the resumption of executive control to help define goal hierarchies and monitor goal achievement. Mindfulness meditation helps develop attentional control and the skill of bringing one's mind to the present. Real-life examples are incorporated to illustrate goal attainment failures and successes, and participants practice solving complex, real-life tasks in sessions.~Sessions include instructional material, interactive tasks, discussion of real-life deficits, and homework/practice activities.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Goal Management Training (GMT)
Description: Goal Management Training (GMT) is a cognitive remediation program that emphasises mindfulness and practice in planning and completing goal-oriented behaviours.~Participants are trained to interrupt ongoing disruptive behaviours through the resumption of executive control to help define goal hierarchies and monitor goal achievement. Mindfulness meditation helps develop attentional control and the skill of bringing one's mind to the present. Real-life examples are incorporated to illustrate goal attainment failures and successes, and participants practice solving complex, real-life tasks in sessions.~Sessions include instructional material, interactive tasks, discussion of real-life deficits, and homework/practice activities.
Study: NCT05317585

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous Glucose Monitor
Description: Continuous Glucose Monitor

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose)
Description: Routine Capillary Blood Glucose Monitoring (Fingerstick Glucose)
Study: NCT05280457

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: nivolumab-GX-188E-GX-I7
Description: * Nivolumab 3 mg/kg IV administered every 2 weeks~* GX-188E 2 mg IM at Weeks 1, 2, 4, 7, 10, 13, and 19~* GX-I7 1200 μg/kg or the recommended dose of the introductory safety cohort is administered at weeks 2, 10, and 18
Study: NCT04737824

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: An adaptation of the balloon-blowing exercise
Description: The participants were positioned in supine, on a semi-rigid surface, with the upper limbs placed above the level of the head, at rest. Their feet were also placed at a resting position on a wall and with their hips and knees at 90o of flexion. The cervical was placed in a neutral position and the pelvis was maintained in a posterior pelvic tilt, both structures corrected by the researcher. The participants were asked to contract the adductors, maintaining a bilateral and symmetric pressure between 10 and 15 mmHg on two sphygmomanometers placed between the knees. Also, an isometric contraction of the hamstrings and gluteus was requested. A Threshold®, with a minimum resistance of 5 cmH2O, and they were instructed to close their lips around the mouthpiece, to avoid air leaks. To start the exercise, it was transmitted to the participants to make a maximum inspiration through the nose, for two seconds. Subsequently, a maximum exhalation throughout the threshold was made for three seconds.
Study: NCT06379256

Intervention type: RADIATION
Intervention: Photon or proton radiotherapy
Description: * 39.6-72.6 Gy (or Cobalt Gray Equivalent, CGE) in 22 fractions for tumors ≤1 cm from hepatic hilum, bowel, and heart.~* 30-66 Gy (or CGE) in 10 fractions for tumors \>1 cm from hepatic hilum, bowel, and heart.~* 27.5-60 Gy (or CGE) in 5 fractions using stereotactic body radiation therapy (SBRT) techniques
Study: NCT05472337

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Colchicine
Description: Oral colchicine (1 mg loading dose followed by 0.5 mg 1 hour later, administered 6 to 24 hours before angioplasty, followed by 0.5 mg (1 comp.) per day for 6 weeks.
Study: NCT06251037

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Youth Aware of Mental Health in Galicia
Description: The program follows a manualized protocol, comprising five interactive one-hour class sessions with adaptations to the Galician school population.~The Inaugural Session consists of an interactive slide presentation, an introduction of materials, the delivery of the manual, and the poster's display. The Second Session involves group discussions on real-life dilemmas. The Third and Fourth Sessions focus on crisis situations, depression, suicidal ideation, and help-seeking behaviors through role-playing games. The Closing Session includes a collective summary of topics and addresses dynamic aspects emerging during the group experience.
Study: NCT05867485

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: COVID-19 Discharge Education
Description: A discharge education brochure has been developed based on information from the literature to complement the verbal information provided to patients. The content of the education brochure includes the following:~1. Information about the spread of the virus and precautions to be taken.~2. Guidelines for cleanliness and disinfection of the environment.~3. Precautions regarding personal and wearable items.~4. Information about food and beverages.~5. Guidelines for personal hygiene practices.~6. Information about quarantine and isolation.~7. Guidelines for maintaining health and care (e.g., respiratory hygiene, cough etiquette, movement, range of motion exercises) (CDC, 2019; Ministry of Health of Turkey, 2020; CDC 2019 A-B-C-D).
Study: NCT05145946

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Video Game Training Group 1
Description: Closed-loop audiomotor game. Home-based training sessions for 3.5 hours per week over an 8-week.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Video Game Training Group 1
Description: Closed-loop audiomotor game. Home-based training sessions for 3.5 hours per week over an 8-week.

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Video Game Training Group 2
Description: Auditory memory game. Home-based training sessions for 3.5 hours per week over an 8-week.

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Video Game Training Group 2
Description: Auditory memory game. Home-based training sessions for 3.5 hours per week over an 8-week.
Study: NCT04737824

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: An adaptation of the balloon-blowing exercise for seven weeks, three times a week, at home
Description: The participants were positioned in supine, on a semi-rigid surface, with the upper limbs placed above the level of the head, at rest. Their feet were also placed at a resting position on a wall and with their hips and knees at 90o of flexion. The cervical was placed in a neutral position and the pelvis was maintained in a posterior pelvic tilt, both structures corrected by the researcher. The participants were asked to contract the adductors, maintaining a bilateral and symmetric pressure between 10 and 15 mmHg on two sphygmomanometers placed between the knees. Also, an isometric contraction of the hamstrings and gluteus was requested. A Threshold®, with a minimum resistance of 5 cmH2O, and they were instructed to close their lips around the mouthpiece, to avoid air leaks. To start the exercise, it was transmitted to the participants to make a maximum inspiration through the nose, for two seconds. Subsequently, a maximum exhalation throughout the threshold was made for three seconds.
Study: NCT05919992

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metyrapone 250 mg Oral Tablets
Description: During one phase of the study: Metyrapone (pills of 250mg) on empty stomach: Day 1 0-1-1, day 2 1-2-2, day 3 2-3-3 day 4 3-4-4 day 5 4-4-4 day 6 4-4-4 day 7 4-0-0

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hydrocortisone 19.9mg s.c., pulsatile with a flow rate of 10μl/s
Description: Hydrocortisone will be delivered subcutaneously via a pump in a pulsed fashion with a flow rate of 10μl/s from day 1 to day 7 in a total daily dose of 19.9mg

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo 250 mg Tablets
Description: During another phase of the study: identical looking placebo pills starting Day 1 0-1-1, day 2 1-2-2, day 3 2-3-3 day 4 3-4-4 day 5 4-4-4 day 6 4-4-4 day 7 4-0-0

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo (0,9% NaCl solution)
Description: Placebo (0,9% NaCl solution) 19.9 mg/d subcutaneously via a pump in a pulsed fashion with a flow rate of 10μl/s from day 1 to day 7
Study: NCT05930418

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Cardiac MRI
Description: Cardiac Magnetic Resonance provides more sensitive measure of ventricular volume and ejection fraction as well as novel markers of tissue characterization and edema assessment.
Study: NCT06053060

Intervention type: OTHER
Group type: OTHER
Intervention: Randomisation Standard Dynacup or Dynacup One C
Description: Randomisation

Intervention type: OTHER
Group type: OTHER
Intervention: Randomisation Standard Dynacup or Dynacup One C
Description: Randomisation
Study: NCT05083624

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: rehabilation therapy
Description: After comprehensive assessment by doctors, nurses and rehabilitation therapists, patients gradually begin rehabilitation treatment.IMS 0: no mobilisation or passively exercised by staff. IMS 1: sitting in bed and actively exercising .IMS 2: passively moved to chair without standing.IMS 3: sitting over edge of bed.IMS 4: standing in front of bed.IMS 5: transferring bed to chair.IMS 6: marching on spot.IMS 7: walking with assistance of more than one person.IMS 8: walking with assistance of one person.IMS 9: walking independently with a gait aid.IMS 10: walking independently without a gait aid.
Study: NCT04075799

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: high-intensity interval training
Description: The HIIT protocol consists of 8 weeks using stair climbing three times per week. The warm-up will consist of 2 minutes of ascending and descending the stairs at a comfortable pace. The high-intensity intermittent exercise will comprise 6-12 x 30-seconds bouts of ascending at an all-effort. A 30- seconds walking recovery will occur between the exercise bouts. Post-exercise the subject will walk during a 2-minute cool down. Every session will last between 10 to 15 minutes. The number of bouts (6-12) will be increased progressively over the weeks. The first (week 1) and final week (week 8) of the exercise program will be monitored by a trained exercise physiologist. During supervised visits, heart rate and rating of perceived exertion (OMNI scale) will be measured at the end of each bout and after active recovery. Subjects will have the option to request further monitoring if desired.
Study: NCT04866628

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Helichrysum italicum infusion
Description: Comparison of metabolic syndrome components before and after four weeks of daily consumption of Helichrysum italicum infusion.

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Helichrysum arenarium
Description: Comparison of metabolic syndrome components before and after four weeks of daily consumption of Helichrysum arenarium infusion.
Study: NCT05892718

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HCB101
Description: HCB101 administered via. intravenous (IV) infusion.
Study: NCT05504486

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Brexpiprazole
Description: Oral tablet; take once daily; target daily dose of 2 mg
Study: NCT05117281

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levobupivacaine
Description: Plain, isobaric levobupivacaine (0.25%) 1 ml/kg

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levobupivacaine
Description: Plain, isobaric levobupivacaine (0.25%) 0.25 mg/kg
Study: NCT05963607

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Weighted blanket
Description: A blanket sewn with extra weight in it.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Weighted blanket
Description: A blanket sewn with extra weight in it.
Study: NCT05115227

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Education
Description: The team will educate the patient about low back pain and how this can be self-managed.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise
Description: The team will advice the patient to conduct relevant exercises and to stay physical active.
Study: NCT05601622

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Fluid loading
Description: Intravenous administration of 10ml/kg of crystalloids over 10 minutes

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Transthoracic echocardiography
Description: Transthoracic echocardiographic measurement of stroke volume index

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: PVI, RPVI
Description: Continuous measurement of pleth variability index and Rainbow pleth variability index

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tidal volume change
Description: Changing tidal volume for mechanical ventilation as 6, 8, 10 ml/kg
Study: NCT05818059

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Diagnosis of Tuberculosis with computer-aided detection (CAD) software
Description: After enrolment, each subject will be assessed according to ARM 1 (assessment by clinician #1 without CAD) or ARM 2 (assessment by clinician #1 with CAD). Allocation to sequence ARM 1 or ARM 2 will be performed using a computer-generated random assignment list (with a 1:1 ratio), and assignments will be included in sealed opaque envelopes sequentially numbered.~Clinicians cannot be masked to the assessment method (with or without CAD) and cannot be masked to the further assessment (referral for microbiological diagnosis with stool and sputum Xpert) due to care process. However, the statistician will be masked to the assessment during data analysis.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Diagnosis of Tuberculosis with computer-aided detection (CAD) software
Description: After enrolment, each subject will be assessed according to ARM 1 (assessment by clinician #1 without CAD) or ARM 2 (assessment by clinician #1 with CAD). Allocation to sequence ARM 1 or ARM 2 will be performed using a computer-generated random assignment list (with a 1:1 ratio), and assignments will be included in sealed opaque envelopes sequentially numbered.~Clinicians cannot be masked to the assessment method (with or without CAD) and cannot be masked to the further assessment (referral for microbiological diagnosis with stool and sputum Xpert) due to care process. However, the statistician will be masked to the assessment during data analysis.
Study: NCT05735314

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: consultation with a specialist
Description: The intervention consists of consultation with a specialist, use of a nurse navigator to help patients with appointments and help them understand their condition, and use of a data query of the electronic health record (EHR) to identify abnormal test results to make sure they are appropriately addressed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: consultation with a specialist
Description: The intervention consists of consultation with a specialist, use of a nurse navigator to help patients with appointments and help them understand their condition, and use of a data query of the electronic health record (EHR) to identify abnormal test results to make sure they are appropriately addressed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: consultation with a specialist
Description: The intervention consists of consultation with a specialist, use of a nurse navigator to help patients with appointments and help them understand their condition, and use of a data query of the electronic health record (EHR) to identify abnormal test results to make sure they are appropriately addressed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: consultation with a specialist
Description: The intervention consists of consultation with a specialist, use of a nurse navigator to help patients with appointments and help them understand their condition, and use of a data query of the electronic health record (EHR) to identify abnormal test results to make sure they are appropriately addressed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Usual care
Description: Usual care involves primary care physicians ordering additional tests and referrals to evaluate patients with new anemia and decreased glomerular filtration rate (GFR) .

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Usual care
Description: Usual care involves primary care physicians ordering additional tests and referrals to evaluate patients with new anemia and decreased glomerular filtration rate (GFR) .

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Usual care
Description: Usual care involves primary care physicians ordering additional tests and referrals to evaluate patients with new anemia and decreased glomerular filtration rate (GFR) .

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Usual care
Description: Usual care involves primary care physicians ordering additional tests and referrals to evaluate patients with new anemia and decreased glomerular filtration rate (GFR) .
Study: NCT05204160

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Given IV
Study: NCT04804748

Intervention type: OTHER
Intervention: No intervention
Description: no intervention

Intervention type: OTHER
Intervention: No intervention
Description: no intervention
Study: NCT05732142

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Postpartum Integration of Vaccines and Contraception Through Gender-Transformative Programming(PIVoT)
Description: The PIVoT intervention is a 30-minute focused information exchange that supports shared contraceptive decision making. The program includes a gender-equity and family planning curriculum covering basic family planning information as well as gender norms and son preference and interactive family planning method index cards (detailing method characteristics, use, duration of action, efficacy, side effects, and contraindications for each method). The program is designed to support person-centered contraceptive choice and encourages women to consider joint family planning decision-making with male partners. If a contraceptive method is desired, it will be provided by nurses who are trained to provide comprehensive family planning care.
Study: NCT05380284

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Senior Driving Simulation Training
Description: The experimental group (Senior Driving Simulation Training: 30-mins training session two times per week for 5 weeks, with a total of 10 sessions) .

Intervention type: OTHER
Group type: OTHER
Intervention: Waiting list control
Description: The control group is waiting list control. They will also receive the (Senior Driving Simulation Training) after all research is done.
Study: NCT04351373

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluorescein Sodium
Description: Intravenous administration 1 mg/kg initial dosing if insufficient additional doses of 1 mg/kg may be administered.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: YELLOW560 filter
Description: Integrated fluorescence module serves to make fluorescent areas visible to assist in visualizing tumor during the resection.
Study: NCT05441111

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Common Elements Toolbox
Description: COMET consists of the following modules: cognitive restructuring (labeled flexible thinking), behavioral activation (labeled positive activities), gratitude, and self-compassion. Participants complete these COMET modules by themselves. The format is reading psychoeducational along with completing specific activities

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Common Elements Toolbox
Description: COMET consists of the following modules: cognitive restructuring (labeled flexible thinking), behavioral activation (labeled positive activities), gratitude, and self-compassion. Participants complete these COMET modules by themselves. The format is reading psychoeducational along with completing specific activities

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Doing What Matters in Times of Stress: An Illustrated Guide
Description: From the WHO's website: Doing What Matters in Times of Stress: An Illustrated Guide is a stress management guide for coping with adversity. The guide aims to equip people with practical skills to help cope with stress. A few minutes each day are enough to practice the self-help techniques. The guide can be used alone or with the accompanying audio exercises.~Informed by evidence and extensive field testing, the guide is for anyone who experiences stress, wherever they live and whatever their circumstances.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Doing What Matters in Times of Stress: An Illustrated Guide
Description: From the WHO's website: Doing What Matters in Times of Stress: An Illustrated Guide is a stress management guide for coping with adversity. The guide aims to equip people with practical skills to help cope with stress. A few minutes each day are enough to practice the self-help techniques. The guide can be used alone or with the accompanying audio exercises.~Informed by evidence and extensive field testing, the guide is for anyone who experiences stress, wherever they live and whatever their circumstances.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Guided self-help
Description: Participants in the guided self-help condition are assigned an eCoach who provides emotional support as well as who promote adherence to the intervention
Study: NCT06622564

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Before CPB Tranexamic Acid
Description: Tranexamic acid 1 to 10 g (10 to 100 mL) administered intravenously as per standard care at the induction of anesthesia as a bolus and/or continuous infusion (i.e., before CPB).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: After CPB Tranexamic Acid
Description: Tranexamic acid 5 g (50 mL) administered after heparin reversal (i.e., after CPB).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Before CPB Placebo
Description: Placebo (10 to 100 mL saline) administered intravenously at the induction of anesthesia as a bolus and/or continuous infusion.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: After CPB Placebo
Description: Placebo (50 mL saline) administered after heparin reversal.