TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06683703

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Utidelone combined with Bevacizumab
Description: In the combination group, the dose of Utidelone was determined according to the safety run-in period, 30 mg/m2/d or 25mg/m2/d, D1-D5,Q3W; The dose of Bevacizumab was 15 mg/kg/3W.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Utidelone combined with Bevacizumab
Description: The dose of Utidelone was 30 mg/m2/d or 25mg/m2/d, D1-D5,Q3W; The dose of Bevacizumab was 15 mg/kg/3w.
Study: NCT06684873

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AK112 Injection
Description: AK112 injection plus chemotherapy was administered to all eligible patients
Study: NCT06683638

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doxycycline 200mg daily for 14 days
Description: Doxycycline will be taken as a single dose of 200mg daily, rather than the current CDC-recommended 100mg twice daily regimen for early syphilis. The duration will still be 14 days of therapy.
Study: NCT06684444

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: firefighter Sleep Health Coaching Intervention (ffSHC)
Description: This multi-component intervention is based on principles of cognitive behavioral therapy for insomnia. It includes telephone-based sleep health coaching to individuals, targeted training and sleep health education to fire service leaders, agency-level sleep health promotion, and facilitation strategies to internal facilitators.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control (Minimally Enhanced Usual Care)
Description: The control arm is minimally enhanced usual care. Usual care interventions for sleep disturbance include any health or wellness interventions administered by the agency on the topic of sleep, including occupational health intervention, employee assistance programs, education, signage, and webinars. The type and dose of care will be assessed at each timepoint. Minimal enhancement is a referral to the agency's Employee Assistance Program and will address the ethical problem in the control condition of identifying but not treating a sleep disturbance.
Study: NCT06684717

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Educational video intervention
Description: A 3-minute educational video mainly about the benefits of Continuous positive airway pressure therapy in OSA patients. The video starts with basic knowledge about OSA and how it affects human health. What is a CPAP machine and how does it works? It was developed from consensus among expert opinions of Neurobehavioral specialists and sleep physicians.
Study: NCT06682559

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Prefabricated healing abutment with scan peg
Description: 12 participants will receive single posterior implants by fully guided implant protocol followed by placement of prefabricated healing abutment with scan peg having convex emergence profile

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Customized healing abutment
Description: 12 participants will receive single posterior implants by fully guided implant protocol followed by placement of custom healing abutment having concave emergence profile
Study: NCT05381870

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Test Preparation-Reference preparation
Description: Under fasting conditions, subjects randomly divided into TR group were given one tablet of test preparation first, and then one tablet of reference preparation after cleaning period.
Study: NCT06683118

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Rapamycin neurovascular Balloon Catheter
Description: Drug-coated balloon for the symptomatic cerebral atherosclerotic stenosis

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Balloon
Description: Conventional Balloon for the symptomatic cerebral atherosclerotic stenosis
Study: NCT05164367

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atropine sulfate gel (0.01%)
Description: A research nurse will measure 1 gram of gel using a calibrated measuring spoon and will provide it to the participant for self-administration.
Study: NCT05982314

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Gamma-PN3
Description: Experimental whole-cell pneumococcal vaccine
Study: NCT06683950

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aflibercept 8mg
Description: Switching to intravitreal aflibercept 8mg in patients previously treated with faricimab or aflibercept 2mg.~The dosing schedule is as follows.~1. A single dose of 8mg aflibercept was administered to all patients~2. After treatment 1, follow-up observations were conducted at the same intervals as previous treatments. If complete fluid resolution (no evidence of SRF or IRF) is observed, an additional dose of 8mg aflibercept is administered, extending the dosing intervals by two weeks each time.~3. Up to three doses of 8mg aflibercept can be administered.~4. If, after the administration of 8mg aflibercept, follow-up observations reveal remaining SRF or IRF, the study concludes without additional dosing.
Study: NCT06682156

Intervention type: DRUG
Intervention: Carfilzomib
Description: carfilzomib C1: 20mg/m2，D1-2; 27mg/m2，D8-9; 36mg/m2，D15-16 C2 and subsequent cycles: 36mg/m2。
Study: NCT06686433

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Novel infant formula
Description: Infants are fed with the novel infant formula from the date of enrollment to the age of 6 months.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard infant formula
Description: Infants are fed with the standard infant formula from the date of enrollment to the age of 6 months.
Study: NCT06708026

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Action Observation and Motor Imagery (AOMI) training
Description: Participants will watch home-based exercise videos and simultaneously imagine themselves performing these exercises in their minds by following verbal instructions in the videos, without actual execution.
Study: NCT04678336

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CART123 cells; cyclophosphamide; fludarabine
Description: CART123 cells following lymphodepleting chemotherapy in pediatric patients with relapsed/refractory AML. Subjects will be treated with a single IV dose of CART123 cells on Day 0.
Study: NCT05370157

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: TeamTRACS
Description: TeamTRACS is a team training intervention adapted from TeamSTEPPS (Team Strategies and Tools to Enhance Performance and Patient Safety), a widely used evidence-based team training developed by the Agency for Healthcare Research and Quality. TeamTRACS targets knowledge, skills, and attitudes related to team member roles, shared awareness, communication, mutual support, and goal-setting. TeamTRACS is structured, easy to use, flexible in length and intensity, and requires few resources. It incorporates didactic instruction, discussion, and interactive activities and can be delivered virtually or in-person.
Study: NCT06384339

Intervention type: DIAGNOSTIC_TEST
Intervention: CSIV, Social motive
Description: The CSIV is a self-report measure and assesses interpersonal values using eight octant scales, which are aggregated into overall communion and agency scores, ranging from -4 to +4 .

Intervention type: DIAGNOSTIC_TEST
Intervention: CSIV, Social motive
Description: The CSIV is a self-report measure and assesses interpersonal values using eight octant scales, which are aggregated into overall communion and agency scores, ranging from -4 to +4 .

Intervention type: DIAGNOSTIC_TEST
Intervention: Interpersonal messages and behavior
Description: The Impact Message Inventory - Circumplex (IMI-C) Brief Version is a self-report transactional inventory designed to measure a target person's interpersonal behavior on four octant scales dominance, hostility, submissiveness, and friendliness by assessing the covert responses or impact messages of another person. Each subscale consists of 7 items, with each item scored on a 4-point Likert scale from 1 (not at all) to 4 (very much so). The minimum score per scale is 7 and the maximum score is 28.

Intervention type: DIAGNOSTIC_TEST
Intervention: Interpersonal messages and behavior
Description: The Impact Message Inventory - Circumplex (IMI-C) Brief Version is a self-report transactional inventory designed to measure a target person's interpersonal behavior on four octant scales dominance, hostility, submissiveness, and friendliness by assessing the covert responses or impact messages of another person. Each subscale consists of 7 items, with each item scored on a 4-point Likert scale from 1 (not at all) to 4 (very much so). The minimum score per scale is 7 and the maximum score is 28.

Intervention type: DIAGNOSTIC_TEST
Intervention: CCS, Social motive
Description: The CCS is a elf-report inventory, that measures tendencies towards competitiveness versus caring in social interactions. The minimum score for the two subscales competitiveness and caring are 9 and the maximum score is 90.

Intervention type: DIAGNOSTIC_TEST
Intervention: CCS, Social motive
Description: The CCS is a elf-report inventory, that measures tendencies towards competitiveness versus caring in social interactions. The minimum score for the two subscales competitiveness and caring are 9 and the maximum score is 90.
Study: NCT05982314

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Gamma-PN3
Description: Experimental whole-cell pneumococcal vaccine

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Gamma-PN3
Description: Experimental whole-cell pneumococcal vaccine

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Pneumovax-23
Description: Licensed pneumococcal vaccine
Study: NCT06708026

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Basic wheelchair exercises
Description: A set of low-intensity warm-up wheelchair exercises developed specifically for survivors with spinal cord injury

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Basic wheelchair exercises
Description: A set of low-intensity warm-up wheelchair exercises developed specifically for survivors with spinal cord injury

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Watch landscape videos
Description: A set of landscape videos
Study: NCT06729983

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Prophylactic Conjoint Tendon Lengthening
Description: During a standard reverse shoulder arthroplasty procedure, the conjoint tendon will be incised and lengthened prophylactically

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Standard Reverse Shoulder Arthroplasty
Description: A standard reverse shoulder arthroplasty procedure will be performed
Study: NCT06744257

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Online Education tool
Description: An online education tool that contains 4 modules
Study: NCT06748183

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Functional Power Training
Description: Group A will participate in Functional Power Training (FPT) alongside routine physical therapy The exercise protocol aims to enhance strength, mobility, and endurance through resistance training across various functional activities. It includes exercises such as running, walking, chair pushing, stair climbing, propelling a stable scooter, and sideways walking, all performed at 50-70% of the participant's maximum speed. Resistance is added using methods like dragging a loaded box with a belt during running and walking, pushing a chair with a loaded box underneath, wearing a loaded vest while climbing stairs, and attaching a loaded box to a scooter for propulsion exercises. Each exercise involves 6 to 8 repetitions lasting 25 seconds, followed by 30 to 50 seconds of rest. This structured regimen focuses on controlled movement and endurance, providing a comprehensive approach to improving physical performance.

Intervention type: OTHER
Group type: OTHER
Intervention: Routine physical therapy
Description: Routine physical therapy for a child with Cerebral Palsy involves hot pack for muscle relaxation and isometric exercises to enhance motor skills, muscle strength, and coordination. Passive stretching will be given as a treatment plan. Therapists employ sit to stand exercise to improve gait, posture, and overall functional abilities. Regular progress evaluations are conducted to adjust interventions, ensuring ongoing improvements.
Study: NCT05592938

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: rPBI
Description: External beam partial breast reirradiation (rPBI) using 26Gy in 5 fractions delivered daily over 1-week
Study: NCT06758557

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HB0025
Description: HB0025 IV every 3 weeks (q3w)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HB0025
Description: HB0025 IV every 3 weeks (q3w)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HB0025
Description: HB0025 IV every 3 weeks (q3w)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HB0025
Description: HB0025 IV every 3 weeks (q3w)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HB0025
Description: HB0025 IV every 3 weeks (q3w)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HB0025
Description: HB0025 IV every 3 weeks (q3w)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pemetrexed
Description: 500 mg/m² iv d1
Study: NCT05990335

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: mHealth application (custom)
Description: Smartphone based application designed to engage user executive functions
Study: NCT05381870

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Reference preparation-Test Preparation
Description: Under fasting conditions, subjects randomly divided into RT group were given one tablet of reference preparation first, and then one tablet of test preparation after cleaning period.
Study: NCT05957523

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Remote ischaemic preconditioning
Description: The participants rested in the supine position for 5 minutes, then turn on the ischaemic preconditioning apparatus and place the automatically programmed blood pressure cuff on both upper arms of the participant, pressurize to 200 mmHg, pressurize for 5 minutes, rest for 5 minutes, perform 4 cycles for a total of 40 minutes each time. The training for participants in group A will be performed once daily, while for participants in group B the training will be performed twice daily. And heart rate and blood pressure before and after each training will be recorded for 7 days.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Remote ischaemic preconditioning
Description: The participants rested in the supine position for 5 minutes, then turn on the ischaemic preconditioning apparatus and place the automatically programmed blood pressure cuff on both upper arms of the participant, pressurize to 200 mmHg, pressurize for 5 minutes, rest for 5 minutes, perform 4 cycles for a total of 40 minutes each time. The training for participants in group A will be performed once daily, while for participants in group B the training will be performed twice daily. And heart rate and blood pressure before and after each training will be recorded for 7 days.
Study: NCT05982314

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Prevenar-13
Description: Licensed pneumococcal vaccine
Study: NCT06318286

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenvatinib
Description: Induction treatment: lenvatinib, 8 mg QD on Day 1 of a 21-day cycle for 4-6 cycles. Maintenance treatment: Lenvatinib, 20 mg QD may be given for up to a total of 35 cycles.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pemetrexed
Description: Pemetrexed, 500 mg/m2 will be given by intravenous (IV) infusion on Day 1 of a 21-day cycle for 4-6 cycles.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin/Carboplatin
Description: Carboplatin (AUC 5 mg/mL/min) or Cisplatin (75 mg/m2) will be given by IV infusion on Day 1 of a 21-day cycle for 4-6 cycles.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab
Description: Pembrolizumab, 200 mg will be given by IV infusion on Day 1 of a 21-day cycle for up to a total of 35 cycles.
Study: NCT05982314

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Saline placebo
Study: NCT06128629

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NTLA-2001
Description: NTLA-2001 (55mg) by IV infusion
Study: NCT05990335

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: mHealth application (custom)
Description: Smartphone based application designed to engage user executive functions
Study: NCT06691282

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mindful self-compassion intervention
Description: Participants will receive six weekly sessions of training by a trainer in mindful self-compassion (MSC). Each session lasting around 90 minutes and will be conducted face-to-face at the Hong Kong Metropolitan University. The content of the intervention will include an introduction of mindfulness and self-compassion, practice of body awareness and loving kindness, skills to deal with challenging experiences, and methods for relating to positive aspects of the self.
Study: NCT06128629

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Normal saline (0.9% NaCl) by IV infusion
Study: NCT04060108

Intervention type: DRUG
Intervention: MDMA
Description: 80mg, 120mg, Placebo
Study: NCT05148299

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pegcetacoplan
Description: 20-cc glass vials-1080 mg
Study: NCT06041971

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: AIDANET system
Description: The study will involve testing a new AID system designed to enable full closed loop control and consisting of the following elements: the diabetes assistant (DiAs) prototyping platform (MAF 2019), connected to a Tandem t:AP research insulin pump and a Dexcom G6 CGM, and implementing the University of Virginia (UVA) AIDANET algorithm.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: AIDANET system
Description: The study will involve testing a new AID system designed to enable full closed loop control and consisting of the following elements: the diabetes assistant (DiAs) prototyping platform (MAF 2019), connected to a Tandem t:AP research insulin pump and a Dexcom G6 CGM, and implementing the University of Virginia (UVA) AIDANET algorithm.
Study: NCT05100095

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Radiation therapy
Description: Hypofractionated radiation therapy to the primary tumor and/or lymph nodes
Study: NCT06296537

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Dynamic Neuromuscular Stabilization Training (DNS)
Description: Dynamic neuromuscular stabilization training has been developed, which optimizes the movement system based on the scientific principles of developmental kinesiology. DNS training aims to stimulate the natural movement control system in the brain to activate the body's stabilization system. Supine, prone, oblique sitting, tripod, high kneeling, hanging stance-midstance faze, hanging stance- propulsion, bear, squat exercises will be applied.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Balance Training
Description: Multi-plane single limb challenges, jumping and landing exercises, proprioceptive exercises, and perturbation exercises

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Training
Description: Education, electrotherapy, soft tissue fascia massage, stretching, range of motion, strengthening and postural control exercises
Study: NCT06688578

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Subperceptual Stimulus
Description: For each test participants will be stimulated using a subperceptual electric signal that is optimized to improve their gait.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Comparator
Description: During intervention trial, sham comparator will consist of same stimulation device but no actual electrical stimulation will be provided by device during intervention trial.
Study: NCT06124690

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Catheter ablation
Description: Pulmonary vein isolation and ablation of low voltage areas.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Catheter ablation
Description: Pulmonary vein isolation and ablation of low voltage areas.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Catheter ablation
Description: Pulmonary vein isolation and ablation of low voltage areas.
Study: NCT06326463

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: 40mg/m2, Day -4, -3 and -2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Day -3 and Day-2~REST DAY, -1

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CD70-CAR T cell infusion (Autologous)
Description: Day 0 or +1

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mesna
Description: Mesna is generally dosed at approximately 25% of the cyclophosphamide dose. It is generally given intravenously prior to and again at 3, 6 and 9 hours following each dose of cyclophosphamide
Study: NCT06694584

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tea(m)Time
Description: Tea(m)Time is divided into two phases, starting with the qualification of team leaders. This starts with knowledge transfer about healthy leadership, resilience, occupational health and safety, posture work, psychological empowerment, agile management and the role of the manager. The team leaders also learn various moderation/coaching techniques. The qualification is followed by the implementation of Tea(m)Time. The teams start each hour with self-reflection. This is followed by a stress assessment and prioritization. The teams then work on the problems identified and look for solutions together.
Study: NCT06688786

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: neoadjuvant mFOLFOX6 chemotherapy combined with PD-1 inhibitor therapy
Description: Preoperative treatment with 4-6 cycles of mFOLFOX6 regimen combined with serplulimab
Study: NCT06690424

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Remimazolam
Description: remimazolam 0.2mg / kg was injected IV during the induction of anesthesia，and remimazolam 0.3-0.5mg / kg / h was administered IV during anesthesia maintenance.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol
Description: Propofol 1.5-2mg / kg was injected IV during the induction of anesthesia，and Propofol 2-3mg / kg / h was administered IV during anesthesia maintenance.
Study: NCT03909685

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mobile Mental Health App
Description: The Mobile Mental Health App is an app that utilizes artificial intelligence to identify symptoms and provides targeted, tailored solutions for its users.
Study: NCT05286229

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ABBV-383
Description: Intravenous (IV) Infusion