TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06032390

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: AI assisted mammography screening interpretation
Description: Screening examinations will be analyzed by the AI system (Transpara, ScreenPoint Medical, Nijmegen, The Netherlands) that assigns each examination a cancer risk score 1-10. Examinations with a score 1-7 will be single read and examinations with score 8-10 will be double read. Examinations selected by one or two readers will be discussed in a consensus meeting. Examinations with an AI score of \>9.8 will be selected for the consensus meeting by default. AI risk scores and image markings are provided to the readers only in the consensus meetings. The readers will decide whether to recall the woman for further assessment in consensus (standard procedure).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard mammography screening interpretation
Description: Screening examinations will be assessed according to standard of care: independently double read, examinations selected by one or two readers will be discussed in a consensus meeting, and the radiologists will decide whether to recall the woman for further assessment. Screening examinations will be analyzed by the AI system retrospectively but the results will not be made available to the radiologist, only used for comparison to the intervention group in results analyses.
Study: NCT04972838

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Remaking Recess (RR)
Description: Remaking Recess is a flexible, school-based social engagement intervention for students with autism and their peers. The research team will work with school personnel to deliver RR during recess. RR is tailored based on the needs of schools, students, and staff.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Remaking Recess (RR)
Description: Remaking Recess is a flexible, school-based social engagement intervention for students with autism and their peers. The research team will work with school personnel to deliver RR during recess. RR is tailored based on the needs of schools, students, and staff.
Study: NCT06433700

Intervention type: OTHER
Intervention: BAS
Description: NOMESCO (Nordic Medico-Statistical Committee) Classification of Surgical Procedures (KJDF10 \& KJDF11 \[gastric bypass\]; KJDF20 \& KJDF21 \[gastric banding\]; KJDF40, KJDF41, KJDF96 \& KJDF97 \[gastric sleeve\]).

Intervention type: OTHER
Intervention: Non-BAS
Description: Patients without BAS codes
Study: NCT06289465

Intervention type: OTHER
Intervention: Observation
Description: Seasonal workers will be assessed in the assessment area established in the hazelnut field and healthy controls will be assessed in their homes.

Intervention type: OTHER
Intervention: Observation
Description: Seasonal workers will be assessed in the assessment area established in the hazelnut field and healthy controls will be assessed in their homes.
Study: NCT06314425

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Immediate dental implants placements on fresh sockets after tooth extraction
Description: Zirconia dental implants (SDS®, Swiss Dental Solution, Kreuzlingen, Switzerland) are to be placed within the fresh extraction sockets. The immediate implants are placed using a minimally invasive technique without vertical releasing incisions. Implant placements are performed following the SDS osteotomy protocol after sulcus marginal and crestal incision or flapless surgery. The same surgeon places implants for all patients. Infected sites are debrided using piezo surgery touch.
Study: NCT05949879

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pecan LOW
Description: Participants are provided with a quantity of pecans that delivers 6% of the participant's estimated energy needs for 28 days.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pecan MID
Description: Participants are provided with a quantity of pecans that delivers 13% of the participant's estimated energy needs for 28 days.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pecan HIGH
Description: Participants are provided with a quantity of pecans that delivers 20% of the participant's estimated energy needs for 28 days.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: CONTROL
Description: Participants are asked to maintain their current habitual diet and to avoid any tree nut/peanut consumption for the entire 28-day intervention period.
Study: NCT06194578

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sterile Saline
Description: Sterile saline will be administered subcutaneously.
Study: NCT04190368

Intervention type: OTHER
Group type: OTHER
Intervention: Team Clinic Care
Description: Participants attend quarterly visits (1 visit every 3months). Appointments scheduled for Telehealth (TH) (1 in-person visits) as decided by provider/patient.~Selected providers will be trained in the Team Clinic Care protocol for completing medical appointments. Team Clinic Care key components:~(1) Shared decision making: Providers, AYA, parent/caregiver will mutually agree on priorities for each medical visit using a shared decision making tool (2) Autonomy supportive care: Providers will be trained in skills building, patient centered key elements, intervention bites, reviewing plans, designed to support AYA autonomy and intrinsic motivation. AYA will also direct extent of eligible family involvement. (3) Goal setting and action planning: Providers will be trained to coach AYA in setting SMART goals, developing action plans, and establishing a plan for follow-up between visits as appropriate. (4) Fidelity Review and process for self-assessment

Intervention type: OTHER
Group type: OTHER
Intervention: Team Clinic Care
Description: Participants attend quarterly visits (1 visit every 3months). Appointments scheduled for Telehealth (TH) (1 in-person visits) as decided by provider/patient.~Selected providers will be trained in the Team Clinic Care protocol for completing medical appointments. Team Clinic Care key components:~(1) Shared decision making: Providers, AYA, parent/caregiver will mutually agree on priorities for each medical visit using a shared decision making tool (2) Autonomy supportive care: Providers will be trained in skills building, patient centered key elements, intervention bites, reviewing plans, designed to support AYA autonomy and intrinsic motivation. AYA will also direct extent of eligible family involvement. (3) Goal setting and action planning: Providers will be trained to coach AYA in setting SMART goals, developing action plans, and establishing a plan for follow-up between visits as appropriate. (4) Fidelity Review and process for self-assessment

Intervention type: OTHER
Group type: OTHER
Intervention: Standard Care
Description: Participants attend quarterly visits (1 visit every 3 months) and see their diabetes care provider. They do not participate in Team Clinic group visits but if they need diabetes education or supportive services they will be referred for necessary care per usual methods.

Intervention type: OTHER
Group type: OTHER
Intervention: Standard Care
Description: Participants attend quarterly visits (1 visit every 3 months) and see their diabetes care provider. They do not participate in Team Clinic group visits but if they need diabetes education or supportive services they will be referred for necessary care per usual methods.
Study: NCT05962944

Intervention type: DEVICE
Intervention: Olympus Cellsens software
Description: Olympus cellsens software will be used to visualise the cells and MS teams screen share will be used to send the live images in real time.

Intervention type: DEVICE
Intervention: Olympus Cellsens software
Description: Olympus cellsens software will be used to visualise the cells and MS teams screen share will be used to send the live images in real time.

Intervention type: DEVICE
Intervention: Olympus Cellsens software
Description: Olympus cellsens software will be used to visualise the cells and MS teams screen share will be used to send the live images in real time.
Study: NCT06354673

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Stellate ganglion block
Description: Sympathectomy by using combination of regional nerve block and systemic drugs

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Stellate ganglion block
Description: Sympathectomy by using combination of regional nerve block and systemic drugs

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexmedetomidine
Description: intravenous Dexmedetomidine infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketamine
Description: intravenous ketamine infusion
Study: NCT06255405

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self-compassion
Description: The dyadic parent-child self-compassion program is designed by the research team and validated by a panel of experts. It includes 5 weekly sessions. Each session lasts for 60 minutes. The dyads will be guided to do self-compassion practices (e.g. affectionate breathing, compassionate letters to oneself etc). Didactic topics, inquiry, and home practices are also involved.
Study: NCT04893863

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Standard dressing
Description: Topical antibiotic ointment (Polysporin™ or formulary equivalent) and non-adherent petrolatum fine-meshed gauze (ADAPTIC™) applied every Monday, Wednesday and Friday (or equivalent).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PluroGel
Description: A 0.5 cm layer of PluroGel® followed by the above standard dressing. In addition, this will be covered with moistened gauze, kept moist twice daily. (The additional factors are the use of PluroGel® and moistened gauze. Standard dressing will continue to be used.)
Study: NCT05323890

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tislelizumab Combined With Neoadjuvant Radiotherapy and Chemotherapy
Description: Patients received tislelizumab at a fixed dose of 200 mg every three weeks (q3w, 21 days) for 2 cycles.
Study: NCT05373485

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: COVID-19 mRNA vaccine
Description: 2 doses of vaccine on Day 0 and Day 21

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: COVID-19 mRNA vaccine
Description: 2 doses of vaccine on Day 0 and Day 21
Study: NCT05108610

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Shi-style manipulations
Description: Shi-style cervical manipulation is a spinal manipulation for cervical radiculopathy.It is a kind of traditional chinese massage and can dredge the meridian.Patients are treated every day for 30 minutes.Seven times at one course and totally there are two courses.3 times a week, once the other day（except the weekends）,30 minutes, 2 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Cervical Traction control
Description: 6kg to 10kg, 3 times a week, once the other day（except the weekends）,20 minutes, 2 weeks.
Study: NCT05957419

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Transapical beating-heart septal myectomy
Description: We have invented a beating-heart myectomy device.Through a minimally invasive intercostal incision, septal myectomy could be accomplished via a transapical access in the beating heart using the device. The whole process of resection is monitored, navigated, and evaluated by real-time transesophageal and transthoracic echocardiography. Left ventricle outlet tract gradient and the grade of mitral regurgitation are evaluated each time after resection. Multiple resections are performed to tailor the muscular resection for sufficient relief of left ventricle outlet tract obstruction and mitral regurgitation, while preventing iatrogenic injuries.
Study: NCT05078580

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iptacopan
Description: Single oral dose of iptacopan 200 mg oral capsules

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iptacopan
Description: Single oral dose of iptacopan 200 mg oral capsules
Study: NCT05253924

Intervention type: DIAGNOSTIC_TEST
Intervention: DNA methylation of target genes
Description: The methylation status of target genes (BDNF, SLC6A4, OXTR, NR3C1, Piezo1, Piezo2, TRPV1 andTRPM8) will be investigated. Saliva sample will be collected for PT and FT. Genomic DNA will be extracted from aliquots of 0. 4 ml of each saliva sample with the Oragene OG575 (DNA Genotek) and stored at -20°C. Aliquots of 250 ng of each DNA will be edited for methylation analysis with the EZ DNA Methylation Lightning kit (Zymo Research). Amplification of samples and their preparation for NGS sequencing will be performed. Samples will be sequenced on NextSeq 500 (Illumina). Individual processed sequences (PE reads) will be independently aligned to reference sequences using a parallel Smith-Waterman algorithm. Only reads that consistently align to the same reference sequence will be retained. At each CpG site in each analyzed sequence, the frequencies of the four bases will be evaluated.
Study: NCT06113770

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: preparation of the tooth to receive CAD CAM PMMA custom made crown
Description: * Open the interproximal contacts .~* The tooth should be reduced circumferentially by approximately 0.5-1mm .~* The preparation margin should be carefully extended and refined to a feather- edge approximately 1-2mm subgingivally .~* Rubber base impression will be taken by BMS additional silicone kit to the prepared tooth and will be sent to the laboratory to be scanned and to design the crown .~* The final crown will be cemented using glass ionomer cement .
Study: NCT05373485

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 2 doses of placebo on Day 0 and Day 21

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 2 doses of placebo on Day 0 and Day 21

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 2 doses of placebo on Day 0 and Day 21

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 2 doses of placebo on Day 0 and Day 21
Study: NCT05710887

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nitrous oxide gas for inhalation
Description: Administration of inhaled 50% nitrous oxide in oxygen (FiO2 0.5) will be under the direct supervision of a licensed practitioner who is experienced in the use and administration of the study drug, and is familiar with the indications, effects, dosages, methods, and frequency and duration of administration, and with the hazards, contraindications, and side effects and the precautions to be taken (MD, or CRNA); with study patient monitoring of pulse oximetry, heart rate, respiratory, non-invasive blood pressure, and end-tidal carbon dioxide.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Administration of the placebo (oxygen-air mixture \[FiO2 ≈0.3\]), will be under the direct supervision of a licensed practitioner who is experienced in the use and administration of the study drug, and is familiar with the indications, effects, dosages, methods, and frequency and duration of administration, and with the hazards, contraindications, and side effects and the precautions to be taken (MD, or CRNA); with study patient monitoring of pulse oximetry, heart rate, respiratory, non-invasive blood pressure, and end-tidal carbon dioxide.
Study: NCT06068504

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Arm-cranking exercise
Description: Arm-cranking exercise

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Heating
Description: Immersion of the foot in warm water
Study: NCT06405386

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ReCharge
Description: ReCharge is an emotions-focused intervention that utilizes core components of Acceptance and Commitment Therapy (ACT) to address and minimize diabetes distress. This 5-week, group-based, virtual intervention will include a stepwise process to address diabetes distress and provide opportunities to practice new skills. Weekly assignments between the sessions will reinforce class material and give additional practice opportunities. Participants will be expected to interact in each session and will have opportunities to share their experiences and be engaged in discussion with the group and the facilitator.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: TakeCharge
Description: TakeCharge is a problem-solving focused intervention that empowers participants to identify and make meaningful changes in their blood glucose management and other diabetes-related behaviors. This 5-week, group-based, virtual intervention will include a stepwise process to analyze data and resolve challenging situations surrounding diabetes management and provide opportunities to practice new skills. Weekly assignments between the sessions will reinforce class material and give additional practice opportunities. Participants will be expected to interact in each session and will have opportunities to share their experiences and be engaged in discussion with the group and the facilitator.
Study: NCT05565586

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: High-Fiber Diet (HFD)
Description: Participants are assigned to the high fiber diet, all meals and snacks will be provided to participants during the study. This diet includes fruits, vegetables and whole grains, a maximum of 18 oz. cooked red meat (including beef, pork, and lamb) per week, and little or no processed meats or added sugars.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Prebiotic Food-Enriched Diet (PreFED)
Description: Participants are assigned to the prebiotic food enriched diet, participants will receive 2 prepared snacks and 1 meal component (a key prebiotic ingredient to incorporate into meals and simple recipes) each day. Participants will also receive a handout that includes key prebiotic foods to incorporate into your own diet.
Study: NCT06632782

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Breath Awareness using pyramid
Description: Participants are provided 1-2 hr training for 6 weeks on bringing breath awareness to the present moment using a pyramid
Study: NCT05481736

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Psilocybin
Description: COMP360 Psilocybin administered under supportive conditions

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: COMP360 Psilocybin administered under supportive conditions
Study: NCT05078580

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iptacopan
Description: Single oral dose of Iptacopan 200 mg oral capsules

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iptacopan
Description: Single oral dose of Iptacopan 200 mg oral capsules
Study: NCT04781582

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Lung volume reduction surgery
Description: Surgical lung volume reduction

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Bronchoscopic lung volume reduction
Description: Bronchoscopic lung volume reduction by endobronchial valves
Study: NCT05155982

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: COVAC-1
Description: Intramuscular vaccine against SARS-CoV-2

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: COVAC-1
Description: Intramuscular vaccine against SARS-CoV-2

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: COVAC-1
Description: Intramuscular vaccine against SARS-CoV-2

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: COVAC-1
Description: Intramuscular vaccine against SARS-CoV-2

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Saline Placebo
Description: Intramuscular injection of saline placebo

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Saline Placebo
Description: Intramuscular injection of saline placebo

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Saline Placebo
Description: Intramuscular injection of saline placebo

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Saline Placebo
Description: Intramuscular injection of saline placebo
Study: NCT05253924

Intervention type: DIAGNOSTIC_TEST
Intervention: DNA methylation of target genes
Description: The methylation status of target genes (BDNF, SLC6A4, OXTR, NR3C1, Piezo1, Piezo2, TRPV1 andTRPM8) will be investigated. Saliva sample will be collected for PT and FT. Genomic DNA will be extracted from aliquots of 0. 4 ml of each saliva sample with the Oragene OG575 (DNA Genotek) and stored at -20°C. Aliquots of 250 ng of each DNA will be edited for methylation analysis with the EZ DNA Methylation Lightning kit (Zymo Research). Amplification of samples and their preparation for NGS sequencing will be performed. Samples will be sequenced on NextSeq 500 (Illumina). Individual processed sequences (PE reads) will be independently aligned to reference sequences using a parallel Smith-Waterman algorithm. Only reads that consistently align to the same reference sequence will be retained. At each CpG site in each analyzed sequence, the frequencies of the four bases will be evaluated.

Intervention type: DIAGNOSTIC_TEST
Intervention: EEG acquisition
Description: Both PT and FT infants will have their EEG signal recorded during mother-baby interaction according to a modified version of the Still Face paradigm; the EEG signal will be recorded by means of the medical system eego mylab (AntNeuro), using special headphones equipped with 32 electrodes and suitable to acquire the EEG signal since early childhood. After spectral analysis of the EEG signal, the difference in signal strength in the alpha band recorded by two homologous electrodes (or electrode clusters) (i.e. right alpha - left alpha) will be calculated to obtain the FAA index. Because the alpha frequency band is associated with cortical inhibitory activity, a lower asymmetry reflects less left hemisphere activation than right hemisphere activation. The analysis of EEG data will be performed in MatLab environment using the eeglab software and algorithms developed ad hoc.

Intervention type: DIAGNOSTIC_TEST
Intervention: EEG acquisition
Description: Both PT and FT infants will have their EEG signal recorded during mother-baby interaction according to a modified version of the Still Face paradigm; the EEG signal will be recorded by means of the medical system eego mylab (AntNeuro), using special headphones equipped with 32 electrodes and suitable to acquire the EEG signal since early childhood. After spectral analysis of the EEG signal, the difference in signal strength in the alpha band recorded by two homologous electrodes (or electrode clusters) (i.e. right alpha - left alpha) will be calculated to obtain the FAA index. Because the alpha frequency band is associated with cortical inhibitory activity, a lower asymmetry reflects less left hemisphere activation than right hemisphere activation. The analysis of EEG data will be performed in MatLab environment using the eeglab software and algorithms developed ad hoc.
Study: NCT06505174

Intervention type: OTHER
Intervention: Hydroxypropyl Guar-based artificial tears four times per day
Description: Use of hydroxypropyl Guar-based artificial tears four times per day
Study: NCT06276283

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DZD9008 plus Bevacizumab
Description: DZD9008, 200 mg or 300 mg, once daily plus Bevacizumab 15 mg/kg, once every 3 weeks