TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04664062

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Medication Assisted Treatment
Description: All subjects will undergo MAT induction with buprenorphine. Participants will be randomized to the behavioral aspects of induction, specifically comparing office induction vs home vs synchronous telehealth induction.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Medication Assisted Treatment
Description: All subjects will undergo MAT induction with buprenorphine. Participants will be randomized to the behavioral aspects of induction, specifically comparing office induction vs home vs synchronous telehealth induction.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Medication Assisted Treatment
Description: All subjects will undergo MAT induction with buprenorphine. Participants will be randomized to the behavioral aspects of induction, specifically comparing office induction vs home vs synchronous telehealth induction.
Study: NCT05391698

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral Parent Training (BPT)
Description: The parent training consists of 8 weekly group sessions where parents are trained on behavior modification techniques, optimal parental practices as well as techniques for the enhancement of their children's cognitive deficits.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral Parent Training (BPT)
Description: The parent training consists of 8 weekly group sessions where parents are trained on behavior modification techniques, optimal parental practices as well as techniques for the enhancement of their children's cognitive deficits.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Child Training (iVR + CBT)
Description: The child training program is comprised of 16 individualized weekly sessions. It utilizes the potentials of immersive virtual reality (iVR) technology for the training of focused and sustained attention and combines practices based on cognitive-behavioral approach for children's training on behavioral and emotional self-regulation skills.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Child Training (iVR + CBT)
Description: The child training program is comprised of 16 individualized weekly sessions. It utilizes the potentials of immersive virtual reality (iVR) technology for the training of focused and sustained attention and combines practices based on cognitive-behavioral approach for children's training on behavioral and emotional self-regulation skills.
Study: NCT05437926

Intervention type: DEVICE
Intervention: Arrhythmia Analysis Software (software) which runs on a mobile application (Huawei Phone) and uses input from a wearable device (smart watch or smart band).
Description: Subjects with or without cardiac arrhythmias and of light skin tone (melanin index \<150) or dark skin tone (melanin index \>350). Subjects will be divided based on their heart rhythm in three groups: approximately 1/3 with normal sinus rhythm, 1/3 with atrial fibrillation and 1/3 with premature beats
Study: NCT05429320

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Local ablative therapy
Description: In part I, 33 patients with metastatic NSCLC with: a) NR-VAF but b) without radiographic progression of disease, will be treated with LAT. In Part II of the study, patients will be randomized to standard of care (continuation of systemic therapy) vs. LAT to all sites of disease

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Local ablative therapy
Description: In part I, 33 patients with metastatic NSCLC with: a) NR-VAF but b) without radiographic progression of disease, will be treated with LAT. In Part II of the study, patients will be randomized to standard of care (continuation of systemic therapy) vs. LAT to all sites of disease

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood collection to assess for ctDNA
Description: Participants will undergo ctDNA collection in conjunction with their standard of care therapy.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood collection to assess for ctDNA
Description: Participants will undergo ctDNA collection in conjunction with their standard of care therapy.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Blood collection to assess for ctDNA
Description: Participants will undergo ctDNA collection in conjunction with their standard of care therapy.
Study: NCT04848012

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Auto-titrating non-invasive ventilation
Description: A non-invasive ventilator designed to auto-adjust the expiratory positive airway pressure according to expiratory flow limitation, measured using the forced oscillation technique.
Study: NCT05609851

Intervention type: OTHER
Intervention: Short Physical Performance Batary
Description: The SPPB includes usual walking speed over 4 m, five chair-stands test, and balance test. A score (scale: 0-4) was assigned to performance on time to rise five times from a seated position, standing balance, and 4-m walking velocity. Individuals received a score of 0 for each task they were unable to complete. Participants coded in the unable to perform category included (a) those who tried but were unable and (b) the interviewer or participant felt it was unsafe. Summing the three individual categorical scores, a summary performance score was created for each participant (range: 0-12), with higher scores indicating better lower body function.

Intervention type: OTHER
Intervention: Occupational Balance Self-Assessment
Description: The Occupational Self-Assessment (OSA) is a self-reported assessment tool consisting of 21 items in which the patient rates their occupational competence (i.e., how well they do) and value (i.e., how important it is to them). The first 11 items are related to skills and occupational performance, the next five items concern habitation (including habits and roles), and the last five items correspond to volition (including personal causation, values, and interests). In the OSA, each item is scored on two separate 4-point scales, one for occupational competence (1 = I have a lot of problems doing this; 4 = I do this extremely well) and the other for value (1 = This is not important to me; 4 = This is most important to me).~The individual item scores are summed to obtain separate total scores for competence and value. Higher total scores indicate higher occupational competence and value.
Study: NCT05780008

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Eat My ABCs
Description: The Eat My ABCs curriculum incorporates senses into learning (hear, see, smell, taste) and includes two sessions/week: 1) healthy eating learning; and 2) mindful food taste-testing activities to expose children to the one fruit, one vegetable, and relevant food items made from the one fruit and one vegetable to teach children the creative ways to make fruit/vegetable healthy and tasty.~Child Letter to Parents. Every week, each child will create one letter, using stickers, regarding the one fruit and one vegetable presented in the program that he/she tasted or wanted to try at home.~Program Cookbook. The investigators have developed a targeted program cookbook for low-income families. The program cookbook contains all budget-friendly recipes for healthy breakfasts, family meals, quick-fixes, kid-friendly snacks, and occasional sweets. In addition, the cookbook contains creative ways of making fruit/vegetable healthy, tasty, and kid-friendly at home.
Study: NCT05409846

Intervention type: DIAGNOSTIC_TEST
Intervention: Alfa-galactosidase activity and genetic testing for Fabry diagnosis
Description: Dry blood spot analysis and blood sample (if necessary)

Intervention type: DIAGNOSTIC_TEST
Intervention: Alfa-galactosidase activity and genetic testing for Fabry diagnosis
Description: Dry blood spot analysis and blood sample (if necessary)
Study: NCT06430242

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Tele rehabilitation
Description: In the active group, one of the co-investigators will install and demonstrate the use of the mobile app (Rehab App) on participants' mobile phone and explain the use of the software. The participants will be followed up for the duration of their enrolment in the e-health and tele-rehabilitation service, which can last up to 2 months.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercise
Description: Participants in the control group will get the usual treatment from the clinical staff and in-person education, and they will be supervised by one of the assigned research team members every week.
Study: NCT05446194

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Non invasive neuromodulation device pattern 1
Description: The study device consists of a headset, which looks like a music earphone headset, and a base station that powers the headset. The headset has metallic earpieces that fit into the ear canals. When activated, the study device will deliver a prescribed stimulation pattern for approximately 20 minutes.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Non invasive neuromodulation device pattern 2
Description: The study device consists of a headset, which looks like a music earphone headset, and a base station that powers the headset. The headset has metallic earpieces that fit into the ear canals. When activated, the study device will deliver a prescribed stimulation pattern for approximately 20 minutes.
Study: NCT05229419

Intervention type: OTHER
Intervention: complete blood count
Description: complete blood count will be done for corrosive cases
Study: NCT06050577

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: oral Semaglutide/Rybelsus
Description: Weeks 1-4: 3 mg of oral semaglutide once daily. Weeks 5-52: 7 mg of semaglutide once daily as maintenance dose. Dose may be increased to 14 mg of semaglutide once daily as maintenance dose after 2 months if glucose levels are out of range.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Weeks 1-4: 3 mg of oral placebo once daily. Weeks 5-52: 7 mg of placebo once daily as maintenance dose. Dose may be increased to 14 mg of placebo once daily as maintenance dose after 2 months if glucose levels are out of range.
Study: NCT04368104

Intervention type: DIAGNOSTIC_TEST
Intervention: Darwish test (office hysteroscopic bubble suction and tubal peristalsis)
Description: Testing Darwish test (office hysteroscopic bubble suction test and proximal tubal peristalsis) in women using minipills versus other cases not using hormones..

Intervention type: DIAGNOSTIC_TEST
Intervention: Darwish test (office hysteroscopic bubble suction and tubal peristalsis)
Description: Testing Darwish test (office hysteroscopic bubble suction test and proximal tubal peristalsis) in women using minipills versus other cases not using hormones..
Study: NCT05337150

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lifestyle Modification Intervention
Description: For the first 12-weeks of the study, participants will complete weekly web modules in which they will learn cognitive-behavioral strategies to support lifestyle modification. Participants will also receive weekly phone coaching calls for the first 12-weeks of the study, and monthly coaching calls thereafter for the remainder of the 24-week study period.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lifestyle Modification Intervention
Description: For the first 12-weeks of the study, participants will complete weekly web modules in which they will learn cognitive-behavioral strategies to support lifestyle modification. Participants will also receive weekly phone coaching calls for the first 12-weeks of the study, and monthly coaching calls thereafter for the remainder of the 24-week study period.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Balanced Calorie Deficit Eating Plan
Description: Participants will be prescribed a calorie target between 1200 and 1800 depending upon baseline weight and personal preference. Participants will be asked to monitor their dietary intake using MyFitnessPal and to submit food logs weekly. Calorie reduction content will be based primarily on the Diabetes Prevention Program protocol and adapted from existing behavioral treatment protocols. Individuals will receive general guidelines on eating a healthy diet, including reducing saturated fat, processed foods, refined sugars, and refined carbohydrates, and increasing intake of lean proteins, whole grains, and fruits and vegetables, but will be encouraged to flexibly decide which areas of their diet to modify to reduce calorie intake.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Ad Libitum Whole Food Plant-Based Eating Plan
Description: Participants will be prescribed a whole food plant-based (WFPB) low-fat vegan diet promoting intake of fruits, vegetables, starches, legumes, and whole grains. Participants will be encouraged to avoid processed foods, refined oils, and animal products (meat, fish, eggs, and dairy products), and to minimize consumption of high-fat plant-based foods. An adapted traffic-light diet chart will outline foods to eat daily, limit, and avoid. Participants will be advised to eat until satiation and not restrict energy intake. Participants will be asked to consume 50 μg vitamin B12 (methylcobalamin) daily. WFPB nutrition counseling content will be based upon existing successful programs. Each week, participants will complete a simplified dietary self-monitoring food frequency questionnaire aligned to correspond with the traffic light diet chart.
Study: NCT06042192

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TK-254RX
Description: Two TK-254RX per day to predetermined application site

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TK-254RX
Description: Two TK-254RX per day to predetermined application site
Study: NCT05849636

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ALERTA CANNABIS
Description: The intervention consists of preventive messages about the benefits of not consuming cannabis, reducing the positive attitudes and encouraging the negative attitudes towards cannabis use, as well as social influence and self-efficacy, by personalized feedback. Skills and action plans are encouraged to help the student to reject cannabis use. This information is presented through different tailored messages. In addition, the participants will be able to choose avatars to accompany them during the intervention. The intervention consists of a short story about the cannabis use by adolescents.The stories take place in three different scenarios (at home, at school leaving, and in public places).
Study: NCT04833660

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive transcranial magnetic stimulation (rTMS) is a safe, noninvasive, and effective therapeutic intervention that uses an electromagnetic coil applied to the scalp to produce a magnetic field. rTMS induces changes in cortical excitability at the stimulation site and transsynaptically at distant areas. Cortical excitability is increased by high-frequency (≥5 Hz) stimulation and is decreased by low-frequency (1 Hz) stimulation. The application of high-frequency unilateral rTMS to the motor cortex in patients is reported to have a potential to control various types of pain, such as neuropathic pain, fibromyalgia, and musculoskeletal origin pain (myofascial pain syndrome, shoulder pain, and lower back pain).

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive transcranial magnetic stimulation (rTMS) is a safe, noninvasive, and effective therapeutic intervention that uses an electromagnetic coil applied to the scalp to produce a magnetic field. rTMS induces changes in cortical excitability at the stimulation site and transsynaptically at distant areas. Cortical excitability is increased by high-frequency (≥5 Hz) stimulation and is decreased by low-frequency (1 Hz) stimulation. The application of high-frequency unilateral rTMS to the motor cortex in patients is reported to have a potential to control various types of pain, such as neuropathic pain, fibromyalgia, and musculoskeletal origin pain (myofascial pain syndrome, shoulder pain, and lower back pain).
Study: NCT04790539

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-1210
Description: SHR-1210 is a humanized anti-PD-1 IgG4 monoclonal antibody
Study: NCT06332911

Intervention type: DEVICE
Intervention: Shockwave™ Peripheral Intravascular Lithotripsy Balloon M5+
Description: Cracking-not-debulking technique (SHOCKWAVE IVL)
Study: NCT05737342

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: ANKASCIN 568-P Red yeast rice capsules
Description: Product ingredients: ANKASCIN 568-P red yeast rice product 440 mg,microcrystalline ,cellulose,Maltodextrin; capsule shell composition: HPMC (hydroxypropyl methylcellulose), purified water, titanium dioxide, gellan gum.
Study: NCT06791226

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: 18F-AlF-FAPI PET/CT, 18F-FDG PET/CT
Description: Subjects with orbital neoplasms underwent contemporaneous 18F-AlF-FAPI and 18F-FDG PET/CT for diagnosis and staging.
Study: NCT06792422

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oral semaglutide
Description: Participants will receive oral semaglutide once daily.~1. Starting dose 3 mg/day for one month (day 1-28)~2. Intermediate dose 7 mg/day for one month (day 29-56)~3. Maintenance dose 14 mg/day (day 57-182)
Study: NCT06394076

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cross-linked sodium hyaluronate gel for injection containing lidocaine
Description: Cross-linked sodium hyaluronate gel for injection containing lidocaine
Study: NCT06126406

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CEA-targeted CAR-T cells
Description: Administration method: intravenous infusion Subjects will receive conditioning therapy by ludarabine and Cyclophosphamide before cell infusion.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CEA-targeted CAR-T cells
Description: Administration method: intraperitoneal injection Subjects will receive conditioning therapy by Fludarabine and Cyclophosphamide before cell infusion.
Study: NCT05737342

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Capsules
Description: Maltodextrin was used as a placebo
Study: NCT06792422

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Participants will receive an oral placebo once daily.~1. Placebo tablets received on visit 1 (baseline) for one month (day 1-28)~2. Placebo tablets received on visit 2 (month 1) for one month (day 29-56)~3. Placebo tablets received on visit 3 (month 2) for four months (day 57-182)
Study: NCT05668949

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TTI-101
Description: Given by PO

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TTI-101
Description: Given by PO
Study: NCT04559412

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sofusa DoseConnect
Description: 25 to 50 mg Enbrel® administered by the Sofusa® DoseConnect™ delivery system once weekly for 12 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Enbrel
Description: 25 to 50 mg Enbrel® administered by the Sofusa® DoseConnect™ delivery system once weekly for 12 weeks
Study: NCT04777123

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: sitting position
Description: patients will be left seated for 2 minutes after subarachnoid injection
Study: NCT06239285

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Brief Violence Intervention VR (BVI-VR)
Description: BVI-VR is being developed as a hospital-based brief gun violence intervention program founded on the principles of positive psychology, motivational goal setting (via gameplay), psychoeducation, cognitive-behavioral therapy, and dialectical behavioral therapy. All steps of the BVI-VR emphasize being in control of making positive choices, and how to locate and leverage opportunities within their communities to improve their well-being. BVI-VR empowers patients to be the driver of their well-being

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Treatment as Usual (TAU)
Description: group will receive a community resource brochure (the same one that is provided at the end of BVI-VR). This brochure provides contact detail for services in the local area. These include organizations that provide mental health counseling, mentorship services, career development programs, organized community activities and sports, educational support, financial support, substance abuse programs, and resource assistance (e.g., food, housing, etc.).
Study: NCT06508151

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: neovaginoplasty and vaginal mold spreaded with photoinduced-imine-crosslink hydrogel
Description: Under general anesthesia and catheterized bladder, the patient was in the lithotomy position. In the connective tissue plane between the bladder and rectum, the vestiges of the müllerian ducts were identified. With the index finger in the rectum as a direction and protection, Hegar's dilators of increasing size (4.5-10) were pushed through the dimples gently. After that, a double-barreled canal appeared. Then, the raphe between the canals was incised. The neovagina was created. According to the randomization, a vaginal mold spreaded with hydrogel or not was placed in the neovagina for 6 months. The patients were suggested to wear the vaginal mold continuously over the following 6 months. After that, they were allowed to have the first sexual intercourse. Otherwise, the mold wearing time was 1 h daily, until they had sexual activity at least twice a week.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: neovaginoplasty and vaginal mold
Description: Under general anesthesia and catheterized bladder, the patient was in the lithotomy position. In the connective tissue plane between the bladder and rectum, the vestiges of the müllerian ducts were identified. With the index finger in the rectum as a direction and protection, Hegar's dilators of increasing size (4.5-10) were pushed through the dimples gently. After that, a double-barreled canal appeared. Then, the raphe between the canals was incised. The neovagina was created. According to the randomization, a vaginal mold spreaded with hydrogel or not was placed in the neovagina for 6 months. The patients were suggested to wear the vaginal mold continuously over the following 6 months. After that, they were allowed to have the first sexual intercourse. Otherwise, the mold wearing time was 1 h daily, until they had sexual activity at least twice a week.