TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05660304

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cortico-cortical paired associative stimulation
Description: Two brain areas will be stimulated with transcranial magnetic stimulation pulses. The pulses will be delivered with a time difference, on other words, one pulse after another.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham cortico-cortical paired associative stimulation
Description: Two brain areas will be stimulated with sham transcranial magnetic stimulation. The sham pulses will be delivered with a time difference, on other words, one pulse after another.
Study: NCT05910632

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Eccentrically strengthened resistance exercise
Description: For each resistance exercise session, 6 to 7 generic exercises will be performed, involving small and large muscle groups (leg extension, leg curl, biceps curl, triceps extension, seated row, shoulder flexion, and shoulder raise). They will perform with 4 sets of 8 repetitions, with a break between exercises of 1 minute and between sets of 2 minutes. They perform those exercises with high intensity (ever 10 on the OMNI-RES Scale).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Traditional resistance training
Description: For each resistance exercise session, 6 to 7 generic exercises will be performed, involving small and large muscle groups (leg extension, leg curl, biceps curl, triceps extension, seated row, shoulder flexion, and shoulder raise). They will perform with 4 sets of 8-12 repetitions, with a break between exercises of 1 minute and between sets of 2 minutes. They perform those exercises with moderate and high intensities (6 to 10 on the OMNI-RES scale).
Study: NCT05900206

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Trastuzumab
Description: Active comparator. IV infusion.

Intervention type: DRUG
Group type: OTHER
Intervention: Pertuzumab
Description: Active comparator. IV infusion.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pertuzumab
Description: Active comparator. IV infusion.

Intervention type: DRUG
Group type: OTHER
Intervention: Ribociclib
Description: Experimental drug. Tablets.

Intervention type: DRUG
Group type: OTHER
Intervention: Letrozole
Description: Experimental drug. Tablets.

Intervention type: DRUG
Group type: OTHER
Intervention: Epirubicin
Description: Active comparator. IV infusion.

Intervention type: DRUG
Group type: OTHER
Intervention: Cyclophosphamide
Description: Active comparator. IV infusion.
Study: NCT05315895

Intervention type: OTHER
Intervention: natural aging process
Description: To observe the relationship between new cases of diseases and health status of people exposed to different factors such as life style, alcohol consumption, eating habits, etc.
Study: NCT05614960

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dried purple laver (Nori)
Description: Dried purple laver (Nori) that has been test to have bioactivity vitamin B12 will be given for intervention groups.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dried purple laver (Nori)
Description: Dried purple laver (Nori) that has been test to have bioactivity vitamin B12 will be given for intervention groups.
Study: NCT06383962

Intervention type: DEVICE
Intervention: Synergy cervical spine disc replacement
Description: motion preservation disc

Intervention type: DEVICE
Intervention: Synergy cervical spine disc replacement
Description: motion preservation disc
Study: NCT06341322

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Standard letter
Description: A reminder letter to encourage recipients to order the colorectal cancer home testing kit, based on the current invite letter.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behaviorally informed letter
Description: A reminder letter to encourage recipients to order the colorectal cancer home testing kit, with incorporates severally behaviorally informed components, including an active choice prompt, social norm, call to action, chunking and simplification.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behaviorally informed letter
Description: A reminder letter to encourage recipients to order the colorectal cancer home testing kit, with incorporates severally behaviorally informed components, including an active choice prompt, social norm, call to action, chunking and simplification.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Home testing colorectal cancer kit
Description: The home testing kit is included with the reminder letter, instead of the usual process of responding to the letter to order the kit
Study: NCT04231838

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: TOBACCO CIGARETTES
Description: Participants in Arm A will continue smoking their own cigarette brand as usual.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: COMBUSTION-FREE NICOTINE DELIVERY SYSTEMS (C-F NDS)
Description: Participants in Arm B will trial and familiarize with their allocated products to select the C-F NDS of their preference. They will be trained and counselled on the chosen C-F NDS; participants will also have the option to try and choose among a selection of either 3 e-liquids or 3 tobacco sticks (depending on the C-F NDS they have chosen). Participants wishing to use a heated tobacco device (HTD) will receive one kit and a full 1 week supply of tobacco sticks of their choice (they will receive a number of tobacco sticks/day corresponding to the number of cigarettes smoked at baseline); those wishing to use a vaping product will receive one vaping kit and a full 1 week supply of e-liquids of their choice (they will receive 4 x 10 ml refill containers).
Study: NCT05934071

Intervention type: DRUG
Intervention: SGLT2 inhibitor
Description: optimization of the medical therapy for heart failure with reduced ejection fraction with SGLT2 inhibitor, according to clinical guidelines
Study: NCT05310097

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CPT
Description: CPT will be delivered over the course of 12 one-hour weekly sessions (maximum of 18 weeks to complete treatment). Participants will have the option of receiving CPT in-person or via videoconferencing.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CPT
Description: CPT will be delivered over the course of 12 one-hour weekly sessions (maximum of 18 weeks to complete treatment). Participants will have the option of receiving CPT in-person or via videoconferencing.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: MS
Description: The MS protocol consists of eight strategies: categorization, evaluation, application, cue-based reminders, practice remembering, attention recruitment, praising recall, and repetitions.
Study: NCT04843878

Intervention type: DIAGNOSTIC_TEST
Intervention: COVID Detect
Description: The study is determining the efficacy of a new rapid COVID testing method.

Intervention type: DIAGNOSTIC_TEST
Intervention: COVID Detect
Description: The study is determining the efficacy of a new rapid COVID testing method.
Study: NCT06191939

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindful Self-Compassion for Lung Cancer (MSC-LC)
Description: The overall goal of this 10-week, group-based, virtually-delivered, psychosocial intervention is to enhance recognition and responsiveness to difficult thoughts and emotions and to build self-compassion skills that facilitate patients' ability to turn inward to those thoughts and feelings with mindfulness, connectedness, and self-kindness. Each weekly session is designed to be 90 minutes and follows an agenda with highly structured scripts covering self-compassion topics (e.g., pain of disconnection, listening with compassion), which are carefully organized to build upon one another. In each session, didactic topics (e.g., What is self-compassion?) taught by trained interventionists lead into guided experiential learning practices (e.g., guided meditation), which are then followed by inquiry into the participants' direct experiences of the practices. The treatment manual is adapted based on the Mindful Self-Compassion Teacher Guide (from the Center for Mindful Self-Compassion).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Enhanced standard of care with waitlist
Description: Participants in the enhanced standard of care control condition will be provided with an information sheet from the NCI about how to find helpful organizations and resources in their community. Self-report will be used to describe any supportive care services pursued by the participant. Additionally, control participants will be added to a waiting list for receiving the MSC-LC intervention program. After completing all questionnaire assessments (16 weeks following study entry), the study team will offer the MSC-LC intervention program to participants on the waiting list.
Study: NCT06320977

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Static Stretching
Description: The static stretching protocol will include the following muscle groups of the dominant lower limb:~* Gastrocnemius - Participants will assume a bipedal position facing a wall. Then, the leg that is not being stretched will be placed forward, with the knee in semi-flexion, and the leg that is being stretched, behind, with the knee in full extension. Instructions will be given in order to keep the calcaneus on the floor;~* Tibialis anterior - Participants will be facing a wall, with the entire foot in touch with the ground and toes pointing forward. Then, they will secure themselves to a handrail and project the hips back.~These stretchings will be held in a position where the participants refer discomfort, and will be maintained for 30 seconds or 90 seconds according to the condition.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Static Stretching
Description: The static stretching protocol will include the following muscle groups of the dominant lower limb:~* Gastrocnemius - Participants will assume a bipedal position facing a wall. Then, the leg that is not being stretched will be placed forward, with the knee in semi-flexion, and the leg that is being stretched, behind, with the knee in full extension. Instructions will be given in order to keep the calcaneus on the floor;~* Tibialis anterior - Participants will be facing a wall, with the entire foot in touch with the ground and toes pointing forward. Then, they will secure themselves to a handrail and project the hips back.~These stretchings will be held in a position where the participants refer discomfort, and will be maintained for 30 seconds or 90 seconds according to the condition.
Study: NCT06185777

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise oncology counseling and referal
Description: Identification \& brief consultation Screening: Needs assessment for exercise therapy Information / educational talk Consultation with the patient Risk assessment (with physician clearance) Consultation Referral to exercise therapy
Study: NCT06433141

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: treatment option for primary second molar
Description: final restoration for primary second molars

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: treatment option for primary second molar
Description: final restoration for primary second molars

Intervention type: PROCEDURE
Group type: OTHER
Intervention: treatment option for primary second molar
Description: final restoration for primary second molars
Study: NCT04763005

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: HIIT exercise intervention
Description: The exercise intervention will be eight weeks of high-intensity interval training (HIIT) started by one warm-up week with an intensity of 75% maximum heart rate (HRmax). In the following seven weeks, the participants will perform a HIIT based on the following protocol and with a total duration of 45 minutes per session: warm-up for 10 minutes at 60-70% HRmax followed by a high-intensity interval consisting of 4x4 minutes at 80-90% HRmax with 3 minutes of active recovery at 60-70% HRmax and a 10 minutes cool-down at 60-70% HRmax. HR will be monitored during training by Polar® H7 heart rate sensors combined with Polar® M400 watches.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Physical activity recommendations
Description: The control group will get physical activity recommendations based on actual guidelines from the European Association of Preventive Cardiology.
Study: NCT05683730

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intermittent caloric restriction
Description: Intermittente caloric restriction:~1. st month: restriction of 50% of the caloric intake previously determined by the dietician 1 day per week~2. nd month: restriction of 50% of the caloric intake 2 days per week~3. rd month: restriction of 60% of the caloric intake 2 days per week~4. th month: restriction of 75% of the caloric intake 2 days per week
Study: NCT05094310

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Acupuncture
Description: Patients with breast cancer who experienced fatigue were measured by the Brief Fatigue Inventory(BFI) scale and other Fatigue related questionnaire. Breast cancer patients diagnosed with cancer related fatigue are included in our clinical study，and those patients will receive acupuncture treatment. The position of acupuncture refers to the principle of acupuncture treatment of traditional Chinese medicine. According to ICD-10-CD code R53.0, the diagnosis of CRF is determined by the experience of diminished energy or other physical and psychological symptoms every day or almost every day for two consecutive weeks in the past month. We collected patients' blood to detect fatigue related SNP.
Study: NCT05019937

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Educational meeting
Description: The investigators will hold a full-day educational meeting. The meeting will include educating 4-5 representatives of each school, and school-district representatives about the guideline and the advantages of adhering to the guideline.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Educational meeting
Description: The investigators will hold a full-day educational meeting. The meeting will include educating 4-5 representatives of each school, and school-district representatives about the guideline and the advantages of adhering to the guideline.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Implementation team
Description: The school-principal forms an implementation team that is responsible for implementing the guideline within their school. The team members (n=4-5) reflect on the implementation progress, make, and refine plans according to Plan-Do-Study-Act, share lessons learned and support each other.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Workshops
Description: The investigators will hold 5 workshops. Workshops will include providing in-depth knowledge and skills on the guideline recommendations. During each workshop one of the guideline recommendations will be presented and discussed.~Moreover, the concept of Plan-Do-Study-Act will be introduced and how it can be used to implement the guideline recommendation(s). During each workshop, the implementation team will share with the group their developed PLAN and barriers and facilitators that have influenced the execution of the PLAN.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Plan-Do-Study-Act improvement cycles
Description: The implementation team will implement the guideline in a cyclical manner by using Plan-Do-Study-Act. First a Plan is specified during the workshop by using SMART-goals, next the change is carried out between workshops (Do), the implementation team analyses whether it went well and what needs to be improved (Study), changes are made (Act) and finally the next cycle is planned.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Internal facilitator
Description: Each municipality assigns one or more internal facilitators, for example HR-strategist. The internal facilitator will meet their local implementation teams during the educational meeting and workshops. Further meeting can be scheduled based on the needs of each implementation team. The internal facilitator will create a supportive environment within which knowledge is exchanged, barriers to implementation identified, and processes or solutions to overcome those barriers developed, applied, and refined. Moreover, the internal facilitator will establish ongoing audit and feedback processes.
Study: NCT06462014

Intervention type: DRUG
Intervention: Relugolix
Description: relugolix
Study: NCT06625593

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BG-C137
Description: Administered intravenously

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BG-C137
Description: Administered intravenously
Study: NCT04816968

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cefepime
Description: Cefepime from 3 to 6 gr, based on patient's clinical status, reduced dose based on organ function and physician discretion, in 100cc saline solution in elastomer, perfused in 24 hours.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Piperacillin/tazobactam
Description: Piperacillin/Tazobactam 18 gr, based on patient's clinical status, reduced dose based on organ function and physician discretion, in 100cc saline solution in elastomer, perfused in 24 hours.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Meropenem
Description: Meropenem 3 gr, based on patient's clinical status, reduced dose based on organ function and physician discretion, in 100cc saline solution in elastomer, perfused in 24 hours.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vancomycin
Description: Vancomycin 30 mg/kg, based on patient's clinical status, reduced dose based on organ function and physician discretion, in 100cc saline solution in elastomer, perfused in 24 hours.
Study: NCT04925817

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Electronic Health Record Review
Description: Medical record reviewed

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ultrasound Microvessel Imaging
Description: Undergo 3D ultrasound microvessel imaging
Study: NCT05661084

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (active)
Description: Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator to the left angular gyrus and prefrontal cortex.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (sham)
Description: A sham transcranial electrical stimulation (tES) will be administered to the participant in their home by their caregiver administrator to the left angular gyrus and prefrontal cortex. It will physically mimic active stimulation.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transcranial alternating current stimulation (tACS) (active); Transcranial direct current stimulation (tDCS) (sham)
Description: Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator. Active tACS to the left angular gyrus and sham tDCS to the prefrontal cortex.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Transcranial alternating current stimulation (tACS) (sham); Transcranial direct current stimulation (tDCS) (active)
Description: Transcranial electrical stimulation (tES), via alternating and direct current, will be administered to the participant in their home by their caregiver administrator. Sham tACS to the left angular gyrus and active tDCS to the prefrontal cortex.
Study: NCT06194045

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: LC-MUFA oil
Description: 2 x 1 g capsules containing marine oil from North Atlantic fish

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 2 x 1 g capsules containing corn oil
Study: NCT06206889

Intervention type: OTHER
Intervention: NAS
Description: NAS Turkish language validation will be carried out. NAS and CNSI scores will be recorded during the shifts of nurses serving patients in Level 3 intensive care units by the nurse in charge and another independent evaluator, and the correlation between the two scores will be investigated.
Study: NCT06348121

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Probiotic
Description: The experimental phase of the study had last 84 days, and each patient will make 4 visits (d0, d28, d56, d84).

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic
Description: The experimental phase of the study had last 84 days, and each patient will make 4 visits (d0, d28, d56, d84).
Study: NCT04774939

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Endovenous laser ablation
Description: The aim is to combine the significance of for sclerotherapy at the primary EVLA treatment

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Endovenous laser ablation
Description: The aim is to combine the significance of for sclerotherapy at the primary EVLA treatment
Study: NCT05546892

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Full bowel preparation prior to colon resection for cancer
Description: Mechanical bowel preparation and oral antibiotics

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: No bowel preparation
Description: Omission of any bowel preparation
Study: NCT05903287

Intervention type: DEVICE
Intervention: Chang Gung Pleural Effusion Detection Software
Description: The Chang Gung Pleural Effusion Detection Software is an independent software as a medical device, which inputs digital Chest X-Ray to automatically detect whether there is a pleural effusion. The inferred results output by this software can assist clinicians or professional medical personnel to identify whether a patient has pleural effusion.~This product is only used to analyze the digitized Chest X-Ray DICOM of patients over 20 years old and under 100 years old.
Study: NCT05662163

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: TIVA
Description: Anesthesia will be maintained with propofol (6-10 mg/kg/hour) and remifentanil (0.1-0.3 μg/kg/min).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: GENERAL ANESTHESIA
Description: Anesthesia will be maintained with sevoflurane (2 ml/min) 50% oxygen and remifentanil (0.1-0.3 μg/kg/min).
Study: NCT06363747

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Very Low Calorie Diet
Description: Optifast is a medically supervised very low-calorie diet (VLCD) diet that safely induces caloric restriction
Study: NCT04672291

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Poly-ICLC (Hiltonol®) or Placebo
Description: The safety cohort (Cohort A) consists of 13 patients who will be randomized to receive 2 cycles of the study drug (N10) or 2 placebo cycles (N3).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Poly-ICLC (Hiltonol®) or Placebo
Description: The expansion cohort will receive 3 cycles of therapy. A total of 30 patients will be accrued and randomized 4:1 to receive drug (N=24) or placebo (N=6).