TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05113277

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tonic Immobility Psychoeducation (TIP)
Description: TIP is a 45-minute computerized psychoeducation intervention aimed at addressing maladaptive cognitions and emotions associated with TI while using educational and behavioral techniques commonly used in the treatment of trauma-related disorders. Throughout the psychoeducation program vignettes will be presented to clarify concepts and promote participant engagement. In addition, practice exercises and rating scales will be integrated, where applicable, to increase the interactive nature of the program. The following modules will be addressed in the TI psychoeducation intervention: education, myth busting, and behavioral experiments.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Health Education Training (HET)
Description: The Healthy Education Training intervention was developed as a 45-minute online intervention that provides education about physical health habits that can impact mental health, such as diet, exercise, and sleep. This intervention has been used in prior clinical trials to control for effects of general education, general coping techniques, and use of technology. Participants in past clinical trials have reported that HET is engaging and beneficial. However, HET is not expected to have an effect on the main symptom outcomes of the current study (guilt, shame, PTSD symptoms).
Study: NCT05965323

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health Education
Description: Health education with comic books and videos
Study: NCT06567223

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Vibration Therapy
Description: will receive the whole body vibration therapy. Patient will be ask to stand on the vibration plate in semi flexed knee position will 3 minute time of rest and therapy. It will be given for four weeks three days per week. Acceleration will be 18.0 meter per second square and frequency will be from 30 to 40 Hz. Intensity of the therapy will increase throughout all the sessions

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: Rhythmic auditory stimulation therapy.
Description: will receive rhythmic auditory stimulation therapy. Rhythmic auditory stimulation will be given for 90 minutes along with 30 minutes of conventional physiotherapy. It will consist of 15 minutes of general body warming metronome rhythm which proceed towards RAS music based exercise of 60 minutes. This period also ends up with 15 minutes of relaxation exercise. Relaxing Music was provided through headphones having voice cancellation property for 15 min. The total session will be given three days per week for four weeks. Exercises such as lateral walking military march, anterior walking, one toe and one heel walking along with posterior walking through progression with the speed of the rhythm is done
Study: NCT06554665

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-intensity interval training group
Description: HIIT sessions will include a 3-minute warm-up, a 20-minute main exercise on a recumbent stepper, and a 2-minute cool-down. The HIIT main exercise will include ten 1-minute high-intensity exercises interspersed with ten 1-minute low-intensity exercises. The high-intensity level will start at 75% of the Heart Rate Reserve (HRR) and will be increased by 5% every 4 weeks to reach 90% at 12 weeks as tolerated.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Moderate-intensity continuous training group
Description: MICT sessions will include a 3-minute warm-up, a 20-minute main exercise on a recumbent stepper, and a 2-minute cool-down. The intensity of the MICT will start at 45% of the Heart Rate Reserve (HRR) and will be increased by 5% every 4 weeks to reach 60% at 12 weeks as tolerated.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Stretching group
Description: Participants in the stretching group will receive 25 minutes of full-body stretching. The intensity of stretching will reach the point of feeling tightness or slight discomfort. Static stretching at each site will hold for 10-30 s and repeat 2-4 times.
Study: NCT05786794

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Patient Navigation Program for Hearing Health Care
Description: Patients presenting for routine office visits will be invited to participate in the study and informed consent procedures and study enrollment will be conducted by a research assistant. Participants will then undergo baseline assessment. Following baseline measures, participants who screen positive for hearing loss will be contacted by the Patient Navigator (PN) to begin the intervention. The navigator will contact participants every 2 weeks to focus on addressing key aspects of Hearing Health Care (HHC): education, screening, diagnosis, and treatment. PNs will assist the patient to undergo a formal audiogram with the 12 months following enrollment. Each PN session will likely last between 10-30 minutes. Post-intervention data collection also administered by a trained interviewer, will occur following a diagnostic audiogram with an audiologist or at 12 months following enrollment.
Study: NCT06274697

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Evaluation by magnetic sensor
Description: Evaluation by magnetic sensor on arm and leg
Study: NCT06567782

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Dostarlimab
Description: Dostarlimab will be administered.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: CAPEOX
Description: CAPEOX chemotherapy consisting of capecitabine and oxaliplatin will be administered.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CAPEOX
Description: CAPEOX chemotherapy consisting of capecitabine and oxaliplatin will be administered.
Study: NCT05761522

Intervention type: OTHER
Intervention: transthoracic echocardiography
Description: * Concerning the main judgment criterion and the secondary judgment criteria:~  * Left ventricular ejection fraction (LVEF) by the Simpson Biplane method,~ * Cardiac output and cardiac index by continuity equation (measurement of left ventricular outflow chamber (mm) and sub-aortic time-velocity integral (cm/s)).~ * Tricuspid Annular Systolic Excursion (TAPSE) (mm)~ * S wave at the tricuspid ring (cm/s)~* Other parameters collected systematically:~  * Surface of the left ventricle (end-systolic and end-diastolic),~ * Global strain of the left ventricle~ * Mitral Annular Plane Systolic Excursion (MAPSE) (mm)~ * Left ventricular filling pressure (LVRP) (at the mitral annulus, E, A, e', S' waves, E/A ratio, E/e');~ * Maximum tricuspid regurgitation velocity (m/s) to estimate systolic pulmonary arterial pressure (PAPs) (mmHg)
Study: NCT06219174

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Difluoromethylornithine
Description: Dose Level -1: 4500 mg/m2 by mouth (PO) daily Dose Level 1: 6750 mg/m2 by mouth (PO) daily Dose Level 2: 9000 mg/m2 by mouth (PO) daily
Study: NCT05702827

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine-Meloxicam
Description: All patients will receive standard of care but the study arm will also receive Bupivacaine-Meloxicam in addition.
Study: NCT05505851

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Hip Flexor Stretch 30 seconds hold 3 repetitions on each side Thoracolumbar extensors stretch 30 second holds 3 repetitions Abdominal Curl ups with hands at side 10 repetitions 2 sets Progression: • Abdominal curl up with arms crossed • Abdominal curl ups with hands behind head Pelvic bridging 10 seconds hold 10 repetitions 2 sets

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sequential Core Stability Corrective Exercise Approach
Description: 1. Corrective Exercises~2. Diaphragm Training Program As per standardized pulmonary rehabilitation guidelines,. Participant will be advised to breathe in gently with an improved tidal volume for ten repetitions, then after a short interval of break 15 repetitions will be done again. 30 Repetitions in set of 15, 15 with the interval rest. 2 sets.~3. Pelvic floor Muscle training Participants will be asked to do pelvic floor training with high intensity (close to maximum) contractions with holding each muscle contraction for 6-8 seconds with relaxation of 6 seconds. Total 8 to 12 contractions.~4. Core Stability exercises~   1. Beginning~  2. Progressing~  3. Advanced
Study: NCT06418074

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Ketone Monoester (KE4)
Description: Each subject will receive beta-hydroxybutyrate boned to R 1,3 Butandiol (KE4) 300mg/kg x 3 for five days. After the treatment period effect variables will be examined.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Ketone Monoester (KE4)
Description: Each subject will receive beta-hydroxybutyrate boned to R 1,3 Butandiol (KE4) 300mg/kg x 3 for five days. After the treatment period effect variables will be examined.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: Each subject will receive a placebo drink 3 x day for five days. After the treatment period effect variables will be examined.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Each subject will receive a placebo drink 3 x day for five days. After the treatment period effect variables will be examined.
Study: NCT06288867

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Arthroscopic Labral Repair
Description: Patients with Hip Labral tears will be treated with labral repair

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Arthroscopic Labral Debridement
Description: Patients with Hip Labral tears will be treated with labral debridement
Study: NCT06393816

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab with etoposide and Carboplatin/Cisplatin
Description: Combination of durvalumab with etoposide and Carboplatin/Cisplatin as First Line Treatment in Patients With Large-cell Neuroendocrine Carcinomas of the Lung.~All patients (either with confirmed diagnosis or not) will be treated and followed-up:~* During the induction: every 3 weeks for 12 weeks (4 cycles)~* During the maintenance: every 4 weeks for 24 months
Study: NCT06405087

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vedolizumab SC
Description: Vedolizumab subcutaneous injection.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vedolizumab SC
Description: Vedolizumab subcutaneous injection.

Intervention type: OTHER
Group type: OTHER
Intervention: No Intervention
Description: As this is an observational cohort, no intervention will be administered.
Study: NCT04986605

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Extracorporeal Photopheresis (ECP)
Description: Drug Intervention using a medical device. The ECP device is already licensed in Canada. License No.7703. ECP treatment, using the drug UVADEX, will be given on 2 consecutive days every 4 weeks for a total of 26 treatment days (48 weeks).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: UVADEX
Description: The phase II aspect of the study refers to the drug, methoxsalen. Methoxsalen is being used off label from the currently approved indications in the monograph. The study is proposing to use methoxsalen in combination with with extracorporeal photopheresis for the treatment of diffuse cutaneous systemic sclerosis. Treatment will be given in addition to standard of care medications for SSc.
Study: NCT05686330

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Apple Watch
Description: Smartwatch for detecting atrial fibrillation using photoplethysmography (PPG)
Study: NCT06556680

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Optical coherence tomography
Description: In the OCT-guided biopsy arm, n=100 study subjects will be enrolled. The investigators will conduct biopsies and imaging using our newly developed OCT catheters and real-time image processing and display algorithms.
Study: NCT04889092

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood Flow Restriction exercise
Description: Exercise training will consist of blood flow restriction exercise. Specifically blood pressure cuff will be wrapped around the most proximal portion of the thigh and inflated to a pressure that is 80% of the pressure required to completely occlude femoral blood flow. With the cuff inflated the subject will perform a series of knee extension/flexion exercise protocol. This consists of 30 reps, 15 reps, 15 reps and 15 reps all separated by 1 minute of recovery. All reps will be performed at 30% of the subjects 1 repetition max. This will be preformed 20 times over 8 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Traditional resistance exercise
Description: Traditional knee extension/flexion exercise will be performed. This will consist of a series of 13 reps, 12 reps, 12 reps with 1 minute recovery between each set. The resistance will be set at 60% of their 1 repetition max. This will be performed 20 times across 8 weeks.
Study: NCT06310434

Intervention type: OTHER
Intervention: questionnaire
Description: COOL Scale and DAS

Intervention type: OTHER
Intervention: questionnaire
Description: COOL Scale and DAS

Intervention type: OTHER
Intervention: Discussion group
Description: Through discussion groups with students in secondary schools and university separately, a compassionate plan will be designed

Intervention type: OTHER
Intervention: Discussion group
Description: Through discussion groups with students in secondary schools and university separately, a compassionate plan will be designed

Intervention type: OTHER
Intervention: Reflective diary
Description: Students can modify the interventions adapting them to their requirements to get the compassion needed for those in need.

Intervention type: OTHER
Intervention: Reflective diary
Description: Students can modify the interventions adapting them to their requirements to get the compassion needed for those in need.
Study: NCT05914584

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Baricitinib 4 MG
Description: Reference drug

Intervention type: DRUG
Group type: SHAM_COMPARATOR
Intervention: Baricitinib 4 MG
Description: Reference drug
Study: NCT06175559

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Healing Town: Embedded Narrative in Interactive Game Design
Description: The game-based medication intervention game Wanping Town in this study employed a multidisciplinary participatory design approach rooted in narrative theory and behavioral psychology models. The game consists of two perspectives: narrative decision stories and cognitive games. The investigators initially employed participatory design methods to determine the plot and elements within the game, then embedded the conclusions into the therapeutic elements of the game
Study: NCT05592210

Intervention type: OTHER
Intervention: Questionnaires
Description: Participants will be asked to fill out the the Demographic Information Sheet, Karitane parenting confidence scale, Parental Stressor Scale: Neonatal Intensive Care Unit (PSS:NICU) and Dyadic Coping Inventory.
Study: NCT05401799

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: BURT
Description: Use of Barrett Upper extremity Robot (BURT) to improve strength and mobility of hemiplegic upper extremity.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Other Occupational Therapy
Description: Standard occupational therapy sessions will be 60-90 minutes a day and are UE neuroeducation sessions are typically focused on improving strength and mobility of the hemipelagic arm.
Study: NCT05266326

Intervention type: OTHER
Group type: OTHER
Intervention: Western medicine conventional treatment +Bloodletting puncture
Description: All acupoints are positioned according to the WHO standard acupuncture point locations in the Western Pacific Region. Operation: The patient is placed in a reasonable position, the acupuncture site is exposed, and the operator uses pushing, rubbing, squeezing and butterfly on or around the acupuncture site to collect blood at the acupuncture site before pricking, and then disinfects the acupuncture site with 75% ethanol. If more bleeding occurs, press with sterile dry cotton balls to stop the bleeding. The treatment was performed once daily for 7 days.

Intervention type: OTHER
Group type: OTHER
Intervention: Western medicine conventional treatment
Description: The patients in both groups were given conventional comprehensive treatment such as improving cerebral circulation, neuroprotection, antiplatelet aggregation, lipid regulation and symptomatic management after admission. Patients with hypertension, hyperglycaemia, hyperlipidaemia and coronary atherosclerotic heart disease were given individualised symptomatic treatment and advised to stop smoking, drinking alcohol and other adverse lifestyles as far as possible.

Intervention type: OTHER
Group type: OTHER
Intervention: Western medicine conventional treatment
Description: The patients in both groups were given conventional comprehensive treatment such as improving cerebral circulation, neuroprotection, antiplatelet aggregation, lipid regulation and symptomatic management after admission. Patients with hypertension, hyperglycaemia, hyperlipidaemia and coronary atherosclerotic heart disease were given individualised symptomatic treatment and advised to stop smoking, drinking alcohol and other adverse lifestyles as far as possible.
Study: NCT06280300

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: health services intervention
Description: Health services intervention

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: health services intervention
Description: Health services intervention
Study: NCT06236126

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: 1% Lidocaine Injection
Description: Prior to insertion of the Tuohy epidural needle, each patient will receive an injection of 3 mL 1% lidocaine either intradermally (Group Intradermal) or subcutaneously (Group Subcutaneous).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: 1% Lidocaine Injection
Description: Prior to insertion of the Tuohy epidural needle, each patient will receive an injection of 3 mL 1% lidocaine either intradermally (Group Intradermal) or subcutaneously (Group Subcutaneous).
Study: NCT06565910

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Liposomal bupivacaine plus bupivacaine
Description: Liposomal bupivacaine is a prolonged-release formulation of the local anesthetic bupivacaine. This intervention involves the administration of liposomal bupivacaine plus bupivacaine as a local anesthetic for the pericapsular nerve group (PENG) block under ultrasound guidance. Liposomal bupivacaine is being investigated for its analgesic effect in postoperative pain management following hip replacement surgery. This formulation is designed to provide extended pain relief as compared to conventional bupivacaine formulations.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ropivacaine
Description: Ropivacaine is a commonly used local anesthetic in clinical practice, and it serves as the active comparator intervention in this study. Participants in the comparator arm will receive ropivacaine as a local anesthetic for the PENG block under ultrasound guidance.
Study: NCT05458193

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Daridorexant
Description: Film-coated tablet for oral use

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Film-coated tablet for oral use
Study: NCT06467318

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Paracetamol
Description: Participants post mechanical pleurodesis on pneumothorax will be divided into two groups: Group A: patients taking classic pain management with NSAID. Group B: patients taking classic pain management without NSAID.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: NSAID, Paracetamol
Description: Participants post mechanical pleurodesis on pneumothorax will be divided into two groups: Group A: patients taking classic pain management with NSAID. Group B: patients taking classic pain management without NSAID.
Study: NCT04720534

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ARO-APOC3
Description: 2 doses of ARO-APOC3 by subcutaneous (sc) injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ARO-APOC3
Description: 2 doses of ARO-APOC3 by subcutaneous (sc) injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ARO-APOC3
Description: 2 doses of ARO-APOC3 by subcutaneous (sc) injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: calculated volume to match active treatment by sc injection
Study: NCT06569576

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Wellness program
Description: It combines seated yoga exercises, mindfulness, and social participation activities and discussions, and can be delivered in-person or via tele-health.
Study: NCT05401799

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Other Occupational Therapy
Description: Standard occupational therapy sessions will be 60-90 minutes a day and are UE neuroeducation sessions are typically focused on improving strength and mobility of the hemipelagic arm.
Study: NCT04904302

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Nivolumab
Description: Given IV

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Quality-of-Life Assessment
Description: Ancillary studies

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaire Administration
Description: Ancillary studies

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sitravatinib
Description: Given PO
Study: NCT06636773

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Diet
Description: A reduced energy diet ranging from 1200-2100 kilocalories per day will be recommended for participants.