Study: NCT05167786

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Noninvasive spinal stimulation with gait training
Description: Transcutaneous Spinal Cord Neurostimulator will deliver transcutaneous electrical spinal cord stimulation while subjects perform lower limb locomotor activities.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Noninvasive spinal stimulation with gait training
Description: Transcutaneous Spinal Cord Neurostimulator will deliver transcutaneous electrical spinal cord stimulation while subjects perform lower limb locomotor activities.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Noninvasive spinal stimulation
Description: Transcutaneous Spinal Cord Neurostimulator will deliver transcutaneous electrical spinal cord stimulation to subjects.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional gait training
Description: Subjects will receive lower limb locomotion training without transcutaneous spinal cord stimulation. However, the amount of time spent in side-lying locomotion training, treadmill training and over ground training will depend on individual tolerance and progression.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional gait training
Description: Subjects will receive lower limb locomotion training without transcutaneous spinal cord stimulation. However, the amount of time spent in side-lying locomotion training, treadmill training and over ground training will depend on individual tolerance and progression.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham
Description: Subject will not receive either transcutaneous electrical spinal cord stimulation or perform lower limb locomotor activities.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
Description: Subjects may receive various lower limb locomotion training with or without transcutaneous spinal cord stimulation. Training approaches may include but are not limited to single or split belt treadmill and over ground walking. Transcutaneous Spinal Cord Neurostimulator may deliver a variety of transcutaneous electrical spinal cord stimulation to subjects.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
Description: Subjects may receive various lower limb locomotion training with or without transcutaneous spinal cord stimulation. Training approaches may include but are not limited to single or split belt treadmill and over ground walking. Transcutaneous Spinal Cord Neurostimulator may deliver a variety of transcutaneous electrical spinal cord stimulation to subjects.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
Description: Subjects may receive various lower limb locomotion training with or without transcutaneous spinal cord stimulation. Training approaches may include but are not limited to single or split belt treadmill and over ground walking. Transcutaneous Spinal Cord Neurostimulator may deliver a variety of transcutaneous electrical spinal cord stimulation to subjects.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
Description: Subjects may receive various lower limb locomotion training with or without transcutaneous spinal cord stimulation. Training approaches may include but are not limited to single or split belt treadmill and over ground walking. Transcutaneous Spinal Cord Neurostimulator may deliver a variety of transcutaneous electrical spinal cord stimulation to subjects.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
Description: Subjects may receive various lower limb locomotion training with or without transcutaneous spinal cord stimulation. Training approaches may include but are not limited to single or split belt treadmill and over ground walking. Transcutaneous Spinal Cord Neurostimulator may deliver a variety of transcutaneous electrical spinal cord stimulation to subjects.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exploratory Phase - Optimization of Gait Training and Spinal Stimulation
Description: Subjects may receive various lower limb locomotion training with or without transcutaneous spinal cord stimulation. Training approaches may include but are not limited to single or split belt treadmill and over ground walking. Transcutaneous Spinal Cord Neurostimulator may deliver a variety of transcutaneous electrical spinal cord stimulation to subjects.