TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05714319

Intervention type: OTHER
Intervention: Data collection
Description: Variables collected will include:~* demographics (sex, age)~* comorbidities (type 2 diabetes mellitus, familiar history of CAD, smoke habit, dyslipidaemia, hypertension, history of CAD)~* echocardiographic (left ventricle ejection fraction at admission, the presence and grade of diastolic dysfunction, and the presence and grade of any valvulopathies)~* angiographic data (presence of non-obstructive CAD (any coronary lesion \<50% diameter stenosis), the presence of myocardial bridge and, if this latter is present, its localization and length)~* laboratory measurements (hematologic variables (haemoglobin and white blood cells), creatinine, high sensitivity cardiac troponin I (hs-cTnI), and C-reactive protein (CRP) at the time of admission)~* medical therapy at admission~* response to intracoronary provocative test with ACh.

Intervention type: OTHER
Intervention: Data collection
Description: Variables collected will include:~* demographics (sex, age)~* comorbidities (type 2 diabetes mellitus, familiar history of CAD, smoke habit, dyslipidaemia, hypertension, history of CAD)~* echocardiographic (left ventricle ejection fraction at admission, the presence and grade of diastolic dysfunction, and the presence and grade of any valvulopathies)~* angiographic data (presence of non-obstructive CAD (any coronary lesion \<50% diameter stenosis), the presence of myocardial bridge and, if this latter is present, its localization and length)~* laboratory measurements (hematologic variables (haemoglobin and white blood cells), creatinine, high sensitivity cardiac troponin I (hs-cTnI), and C-reactive protein (CRP) at the time of admission)~* medical therapy at admission~* response to intracoronary provocative test with ACh.

Intervention type: OTHER
Intervention: Clinical follow-up
Description: All patients will undergo a clinical follow-up by telephonic interview and/or clinical visit at 6, 12, 24, 36, 48 and 60 months from hospital discharge, during which the incidence of MACCE in the past months will be investigated and collected.

Intervention type: OTHER
Intervention: Clinical follow-up
Description: All patients will undergo a clinical follow-up by telephonic interview and/or clinical visit at 6, 12, 24, 36, 48 and 60 months from hospital discharge, during which the incidence of MACCE in the past months will be investigated and collected.
Study: NCT04813003

Intervention type: OTHER
Intervention: Functional Brain Imaging and neurobehavioural tasks
Description: Combination of 3 neurobehavioural tasks:~Task 1 consists in subjective value rating of 64 food items. Participants are asked to rate how much they would want to eat the presented food item while fMRI (functional magnetic resonance imaging ) scanning is performed.~Task 2 consists in rating of subjective nutrient factor of the same 64 food items. Participants will answer the following four categorical questions in randomized order for each item: low or high in added sugar/protein/fat and healthy or unhealthy.~Task 3 consists of a decision-making task. Participants will be presented with two food items (out of the 64 food items), and asked to choose which of the two items they prefer to consume at the end of the experiment.

Intervention type: OTHER
Intervention: Functional Brain Imaging and neurobehavioural tasks
Description: Combination of 3 neurobehavioural tasks:~Task 1 consists in subjective value rating of 64 food items. Participants are asked to rate how much they would want to eat the presented food item while fMRI (functional magnetic resonance imaging ) scanning is performed.~Task 2 consists in rating of subjective nutrient factor of the same 64 food items. Participants will answer the following four categorical questions in randomized order for each item: low or high in added sugar/protein/fat and healthy or unhealthy.~Task 3 consists of a decision-making task. Participants will be presented with two food items (out of the 64 food items), and asked to choose which of the two items they prefer to consume at the end of the experiment.
Study: NCT04634045

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Web Based Treatment
Description: The literature regarding the efficacy of web-based platforms for behavioral weight management interventions in pediatric populations continues to grow. Considering the continued increase in technology and internet use among youth, web-based interventions have the potential to serve as a more cost-effective and personalized approach to pediatric behavioral weight management. Extant research supports this consideration. More research that compares web-based vs. traditional delivery of acceptance-based pediatric behavioral weight management interventions is necessary to understand the utility of this platform as well as which aspects are most effective.
Study: NCT04458688

Intervention type: OTHER
Intervention: Observation of Ocrelizumab as Treatment in RRMS Patients
Description: It is decided by the patient and their physician to begin taking ocrelizumab PRIOR to study enrollment. The study is only observing the effects of ocrelizumab as a pre-decided treatment option for a patient's MS.

Intervention type: OTHER
Intervention: Observation of Ocrelizumab as Treatment in RRMS Patients
Description: It is decided by the patient and their physician to begin taking ocrelizumab PRIOR to study enrollment. The study is only observing the effects of ocrelizumab as a pre-decided treatment option for a patient's MS.
Study: NCT06189235

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Biofeedback training
Description: The target of additional biofeedback training is to provide hints which are related to the essential aspects during hand therapy such as the stress on the tissue and the distance of tendon gliding.
Study: NCT04951167

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Norepinephrine
Description: in the form of infusion

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Norepinephrine
Description: in the form of infusion

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Norepinephrine
Description: in the form of infusion

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Norepinephrine
Description: in the form of bolus

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Norepinephrine
Description: in the form of bolus
Study: NCT05798468

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Augmented reality
Description: The intervention will be carried out in the Physiotherapy Degree of the Universities of Malaga and Cadiz. It will consist of the use of software and a platform that works with augmented reality. Previously a study of the demographic variable of the population that conforms the study will be carried out. During the intervention, teaching will be carried out with the support and enhancement of the use of augmented reality through Zapworks and Aumentaty. A study and analysis of the variables of the qualifications and usability of the study population will be carried out. For the qualification variable, the academic performance of the students will be taken into account and for the usability variable, the System Usability Scale will be used. Subsequently, an analysis and interpretation will be carried out to assess the correlation between both variables.

Intervention type: OTHER
Group type: OTHER
Intervention: Control group
Description: Traditional education will be carried out
Study: NCT04563832

Intervention type: OTHER
Group type: OTHER
Intervention: Standardized respiratory management program
Description: Bronchial decluttering education, respiratory physiotherapy, specialized medical follow-up for 2 years

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standardized respiratory management program
Description: Bronchial decluttering education, respiratory physiotherapy, specialized medical follow-up for 2 years

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: CoughAssist
Description: self-administered mechanical in-exsufflation - CoughAssist (2 x 15 min per day, 5 days per week for 2 years)
Study: NCT04924413

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tislelizumab
Description: PD-1 positive lymphocytes are isolated from peripheral blood and amplified for transfusion
Study: NCT05275361

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Social Contact Reminder
Description: -The social contact will remind patient about screening mammogram appointment
Study: NCT05413434

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise
Description: high-intensity interval training will be performed on the treadmill.
Study: NCT06112041

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ADC Combined With Radiotherapy, PD-L1 Sequential GM-CSF and Thymopentin
Description: RC48-ADC combined with hypofractionated radiotherapy, PD-L1 inhibitor sequential GM- CSF and Thymopentin
Study: NCT05698667

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Transoral ultrasound
Description: Under local anesthetic with xylocaine spray in the oropharynx, the tonsils and tongue base are scanned with small-footprint, high-frequency ultrasound transducers (such as the 18XL5s hockey-stick from BK Medical)

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Transcervical ultrasound
Description: The tongue base and tonsils are scanned externally via the neck, where a (preferably low-frequency) transducer is placed onto the skin above the hyoid bone to visualize the tongue base. The tonsils are visualized adjacent to the tongue base on either side and are located deep to the submandibular glands in a oblique coronal plane.
Study: NCT05413434

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercise
Description: high-intensity interval training will be performed on the treadmill.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: inspiratory muscle training
Description: Respiratory muscle strength exercise will be performed with the respiratory muscle strengthening device 'POWERbreathe Classic Light Resistance'.
Study: NCT05026814

Intervention type: OTHER
Intervention: Interview after one year or more from the treatment received
Description: Questionnaires to evaluate the satisfaction with treatment, the motivations and expectations for the treatment, the general well-being, the sexual function and the genital selfimage
Study: NCT06215768

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexmedetomidine and Midazolam
Description: This will be a prospective, double-blind, randomized controlled study conducted between October 2023and June 2024 .~Patients aged( 2_12) years, American Society of Anesthesiologists class (ASA) I or II, scheduled for tonsillectomy with and without adenoidectomy will be randomized to receive intravenous dexmedetomidine 0.5 μg/kg Or intravenous midazolam 0.1 mg /kg(Group A) or (Group B) over 10 minutes after induction of anesthesia. The primary outcome is the incidence of ED within 30 minutes after extubation. Other outcomes are the incidence of pain, extubation time, post-anesthesia care unit (PACU) length of stay after extubation, adverse events, and the incidence of negative postoperative behavioral changes (NPOBCs).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexmedetomidine and Midazolam
Description: This will be a prospective, double-blind, randomized controlled study conducted between October 2023and June 2024 .~Patients aged( 2_12) years, American Society of Anesthesiologists class (ASA) I or II, scheduled for tonsillectomy with and without adenoidectomy will be randomized to receive intravenous dexmedetomidine 0.5 μg/kg Or intravenous midazolam 0.1 mg /kg(Group A) or (Group B) over 10 minutes after induction of anesthesia. The primary outcome is the incidence of ED within 30 minutes after extubation. Other outcomes are the incidence of pain, extubation time, post-anesthesia care unit (PACU) length of stay after extubation, adverse events, and the incidence of negative postoperative behavioral changes (NPOBCs).
Study: NCT05988502

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: auricular acupressure
Description: The well-trained researcher nurse in this study was performed the AA intervention. First of all, the participant was instructed to find a comfortable position. Disinfect the ears using cotton with 75 % alcohol was then provided and followed by placed vaccaria seeds (Beijing, China) with an adhesive patch onto the unilateral each selected auricular acupoint (left ear first) Participants were pressed each acupoint by thumb and index finger for one minute, four times a day, five days a week, remove the taped seeds on the 6th day, and then replaced the opposite ear two days after. They were noted that they experienced various sensations while pressing, including numbness, swelling, mild pain, or warmth. Seeds were taped on the other side of the ear weekly for two weeks.~Two TCM physicians verified the conduct of the AA protocol, which consisted of a selection of acupoints, length of stimulation time, finding location of acupoint, and procedure of practice.
Study: NCT04740905

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Faricimab
Description: Faricimab will be administered by intravitreal (IVT) injection as specified in each treatment arm.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Faricimab
Description: Faricimab will be administered by intravitreal (IVT) injection as specified in each treatment arm.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aflibercept
Description: Aflibercept 2 mg will be administered by IVT injection once every 4 weeks (Q4W) from Day 1 through Week 20 (a total of 6 injections).

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Sham Procedure
Description: The sham is a procedure that mimics an intravitreal (IVT) injection, but involves the blunt end of an empty syringe (without a needle) being pressed against the anesthetized eye. It will be administered to participants in both treatments arms at applicable visits to maintain masking.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Sham Procedure
Description: The sham is a procedure that mimics an intravitreal (IVT) injection, but involves the blunt end of an empty syringe (without a needle) being pressed against the anesthetized eye. It will be administered to participants in both treatments arms at applicable visits to maintain masking.
Study: NCT06138730

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Appa Complete
Description: Weekly mentorship meetings \& guided CBT videos. Participants assigned to Appa Complete will have unlimited access to the Appa website and materials described in Appa Lite, along with weekly mentorship meetings with a trained and supervised near-peer mentor with whom they have been matched. Matching is based on preference for mentor gender, racial/ethnic minority status, and LGBTQ status and is designed to increase the sense of identification with the mentor and peer-mentor alliance. Virtual meetings begin with a review and discussion of the video and other materials for the week. Mentors ask about how clients are incorporating their CBT learnings into their life, share ways they have used the focal skills in their own lives, illustrate skills use in popular culture, and provide problem solving strategies. Each week has a specific prompt to ensure that clients are applying the concepts and skills they are learning and can talk about any questions or reflections with their mentors.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Appa Lite
Description: Unguided EBP videos and materials. Participants assigned to the Appa Lite condition will have unlimited access to the Appa website, including short form CBT-based videos and materials such as an emotions wheel pdf and thoughts, feelings, and behavior worksheets. The website is structured so that the materials are presented in a developmentally appropriate manner consistent with evidence-based principles in a 12-week format, beginning with general psychoeducation to define mental health, proceeding to introducing CBT and basic CBT skills such as identifying thoughts, feelings, and behaviors, layering on applying specific CBT skills, and ending with reflective journal exercises. Client progress through the materials will be completely unguided.
Study: NCT05412589

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: mFOLFOX7+Camrelizumab+Apatinib
Description: Drug: Leucovorin 200mg/m2 administered IV on Days 1 of a 21 day cycle Drug: Oxaliplatin 85 mg/m2 IV on Days 1 of a 21 day cycle. Drug: Fluorouracil 5-FU continuous infusion: 400mg/m2 on D1 and then 2400mg/m2 for 46h of each 21 day cycle.~Drug: Camrelizumab 200mg infusion on D1 for every 21 days Drug: Apatinib 250mg，po，qd for every 21 days
Study: NCT05526300

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Intelligent Hypertension Management System
Description: The intelligent hypertension management system is used to remotely detect the blood pressure of hypertensive patients

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: The standard care
Description: The standard care
Study: NCT05901467

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: kisspeptin 112-121
Description: One IV bolus of kisspeptin 112-121

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GnRH
Description: One IV bolus of gonadotropin-releasing hormone
Study: NCT05762926

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Transcranial pulse stimulation (TPS)
Description: Clinical treatment consists in ten sessions of neuronavigation system guided halocranial application of 6000 focused sound wave pulses, with energy flux density of 0.25 mJ/mm2, depth of focus of 5 cm and useful energy between 4 to 6 cm, frequency of 4 Hz, total energy applied will be 50 Joules, for it will be used the Storz Neurolith™ equipment.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Transcranial pulse stimulation (TPS)
Description: Clinical treatment consists in ten sessions of neuronavigation system guided halocranial application of 6000 focused sound wave pulses, with energy flux density of 0.25 mJ/mm2, depth of focus of 5 cm and useful energy between 4 to 6 cm, frequency of 4 Hz, total energy applied will be 50 Joules, for it will be used the Storz Neurolith™ equipment.
Study: NCT06392373

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: CHO+PRO
Description: 0.9 g CHO/kg/hr + 0.3 g PRO/kg/hr

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: CHO
Description: 1.2 g CHO/kg/hr
Study: NCT05873127

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: web-based guided self-help Enhanced Cognitive Behavioral therapy
Description: The subjects would learn and practice CBT-E course through the online learning platform for 12 times, and were required to complete the course once a week.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: online Enhanced Cognitive Behavioral therapy
Description: A closed structured group would be established by online video conference for group CBT-E therapy. Each group would receive 12 group sessions, once a week for 120 minutes each time. Each group would be led by two CBT therapists, all of whom are nationally registered psychotherapists with systematic professional training.
Study: NCT04095676

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: VATS group
Description: VATS procedure with drainage, including rinse with NaCl

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Drain and intrapleural therapy group
Description: Drainage with pigtail and Intrapleural therapy
Study: NCT06065111

Intervention type: OTHER
Intervention: study tendon damage in osteogenesis imperfecta patients
Description: * To identify and characterize alterations of tendons and ligaments in patients with osteogenesis imperfecta (OI) and to improve clinical management of the disease.~* To analyze interactions of different parameters, such as laxity or administration of bisphosphonates, on the evolution of the disease.
Study: NCT05214079

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Left paratracheal pressure
Description: Applying Left Paratracheal pressure and testing its effectiveness using gastric tube . in addition , by using the dynamometer , the CP 50 is defined.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Left paratracheal pressure
Description: Applying Left Paratracheal pressure and testing its effectiveness using gastric tube . in addition , by using the dynamometer , the CP 50 is defined.
Study: NCT04802122

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sevoflurane inhalant product
Description: Sevoflurane 8% / O2 100% with the vital capacity breathing method (vital capacity induction, VCI) will be used for induction to anesthesia and facilitate endotracheal intubation.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Propofol Fresenius
Description: Propofol 1,5mg/Kg, supplemented by fentanyl 2mcg/Kg and rocuronium 0,5mg/Kg and O2 100% will be for induction to anesthesia and facilitate endotracheal intubation. .
Study: NCT04005794

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: VR social skills training
Description: Social skills game that we developed in the R21 phase will be used across 10 sessions of training in the lab. Each session is about 1 hour long. Participants come to the lab twice a week for 5 weeks.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Cognitive training
Description: Commercially available cognitive training program will be used to control for the time spent in the lab and associated social interactions as well as the total exposure to computerized games.
Study: NCT06075381

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Pulmonary Expansion Device (PED)
Description: The Pulmonary Expansion Device constitutes an innovative instrumental technique for lung expansion, designed for use in patients with or without an artificial airway. This device is attached to the artificial airway, the oronasal mask, or the patient's mouth. It enables voluntary control through a system of one-way valves that restrict the air's escape from the lungs to the outside. This creates an environment conducive to retaining air within the lungs, thereby increasing intrapulmonary pressure. Additionally, it reduces the risk of pulmonary complications associated with conventional management, employing a strategy free from exogenous application of positive pressure to the airway. This approach doesn't necessitate expensive equipment or electrical power.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional management
Description: The conventional management includes: Adequate postoperative pain control, global postural reeducation, reeducation of breathing pattern, airway hygiene, early mobilization, respiratory and scapular waist exercises, and in patients with evidence of lung atelectasis or mild persistent hypoxemia, conventional management will involve the use of intermittent positive pressure ventilation in the airway.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Conventional management
Description: The conventional management includes: Adequate postoperative pain control, global postural reeducation, reeducation of breathing pattern, airway hygiene, early mobilization, respiratory and scapular waist exercises, and in patients with evidence of lung atelectasis or mild persistent hypoxemia, conventional management will involve the use of intermittent positive pressure ventilation in the airway.