TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04073329

Intervention type: OTHER
Intervention: post operative measure of reduction
Description: measurement was used to grade quality of reduction according to Matta's system . In accordance with prior studies, adequate (or anatomic) reductions with 0-1 mm of displacement were compared to inadequate (imperfect or poor) reductions with \> 1 mm displacement . For the CT-based method, postoperative pre-digital (prior to 2000) and digital CT images were independently assessed in the axial, sagittal, and coronal planes, and residual gap and step displacement were measured along the articular surface at the level of the weight-bearing dome. Adequate reductions on postoperative CT were defined as \< 1 mm step and \< 5 mm gap displacement and inadequate reductions as ≥ 1 mm step and/or ≥ 5 mm gap displacement.

Intervention type: OTHER
Intervention: post operative measure of reduction
Description: measurement was used to grade quality of reduction according to Matta's system . In accordance with prior studies, adequate (or anatomic) reductions with 0-1 mm of displacement were compared to inadequate (imperfect or poor) reductions with \> 1 mm displacement . For the CT-based method, postoperative pre-digital (prior to 2000) and digital CT images were independently assessed in the axial, sagittal, and coronal planes, and residual gap and step displacement were measured along the articular surface at the level of the weight-bearing dome. Adequate reductions on postoperative CT were defined as \< 1 mm step and \< 5 mm gap displacement and inadequate reductions as ≥ 1 mm step and/or ≥ 5 mm gap displacement.
Study: NCT04736511

Intervention type: OTHER
Group type: OTHER
Intervention: Tendon vibration
Description: The subject will be asked to stand, motionless in bipodal (both feet on the ground) support on a stable and unstable ground (foam). A tendon vibration (80Hz) will be randomly applied to the subject in the Achilles tendons or paravertebral muscles. This vibration will cause an alteration of proprioceptive information in the vibrated area leading to a disruption of postural balance. Thus, according to the amount of displacement of the center of pressure (CoP), the proprioceptive weighting ratio (dRPW) is calculated to deduce therefrom the weight assigned by the CNS to the various proprioceptive inputs during the postural task.
Study: NCT04824443

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aerobic Exercise Therapy
Description: Aerobic Exercise Therapy/AT will consist of 30 weeks of treadmill walking sessions. AT will consist of supervised, individualized walking delivered up to 6 times weekly (over a 7-day period) to achieve a cumulative total duration ranging from 90 mins/wk up to 375 mins/wk following a non-linear dosing schedule. The planned dose and scheduling of AT will be continually altered and progressed in conjunction with appropriate rest/recovery sessions across the entire intervention period (i.e., non-linear periodized schedule).
Study: NCT05437250

Intervention type: DRUG
Intervention: Non interventional study
Description: CLL patients initiated with acalabrutinib at their physician's discretion between January 1, 2021 and December 31, 2022 . Secondary data collection
Study: NCT06116643

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Soluble protein hydrolysate (SPHi)
Description: Participants that are already on stable maintenance therapy for ulcerative colitis will continue with their therapy regimen and the addition of 10g of SPHi in 100ml of water every day for 12 weeks.
Study: NCT04121208

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: JNJ-40346527
Description: Active study drug

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Non-active study drug
Study: NCT05416437

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: PneumoCool
Description: Device to channel medical air to the patient to alleviate dyspnea

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Current supportive measures that are used in the hospital for standard of care
Description: a room fan, or any other currently used supportive measures can be used for patients in the control arm
Study: NCT05925881

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Surgical Repair of Large to Massive Rotator Cuff Tears
Description: Surgical procedure to reconstruct the rotator cuff

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Surgical Repair of Large to Massive Rotator Cuff Tears
Description: Surgical procedure to reconstruct the rotator cuff
Study: NCT06464510

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Early Vasopressin
Description: Early Vasopressin group: Vasopressin up to 0.04U/min initiated after randomization.
Study: NCT06086808

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Resistance Training
Description: A resistance training program will be used as a progressive, high-intensity protocol. The training stimulus will be provided using free weights. The exercises will consist of bench presses, biceps curls, triceps extensions, Latissimus Dorsi pull-down exercises, hamstring curls, and calf raises. The intensity of the training stimulus will be at a working range of 6 to 8 repetitions (2 sets). The training stimulus will subsequently be increased using the 7-RM (repetition maximum) method when 2 sets of 6 to 8 repetitions are completed with proper form and without discomfort. Other key strength exercises will include mini-squats, mini-lunges, and lunge walks. The number of sets completed and the load lifted for each exercise will be recorded for each participant in every class.
Study: NCT06464510

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Norepinephrine and Vasopressin for Rescue
Description: Norepinephrine and Vasopressin for Rescue group: Vasopressin up to 0.04U/min initiated only if norepinephrine dose exceeds 0.5 μg/kg/min.
Study: NCT06439719

Intervention type: PROCEDURE
Intervention: Blood sample collection
Description: Collection of blood sample

Intervention type: PROCEDURE
Intervention: Blood sample collection
Description: Collection of blood sample
Study: NCT05341453

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Individual physiotherapy (SMA-SOC)
Description: Therapeutic procedures according to the recommended standard (SMA-SOC) will be used in the therapy. Elements of breathing gymnastics, vibration techniques, stretching, eccentric and concentric exercise procedures will be combined. Individual physiotherapy will be conducted on the basis of set goals from the kinesiological examination, it will be adapted to the individuality of the child - his cooperation, fatigue and sleep time.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Hippotherapy
Description: HT by CP is an accredited form of hippotherapy, whose methodology is based on the clinical picture of cerebral palsy, but its procedures are applicable to a wider group of children with disabilities. Therefore, investigators anticipate it´s effect for children with SMA.~Based on a special type of examination, this method precisely determines the type / breed of the horse according to the biomechanics of the movement of its back in the step, the position of the child and the neurophysiological function of the back - differentiation or sensorimotor skills. Furthermore, according to the course of therapy, the physiotherapist determines the pace of the horse's step, its length, selects special manual contacts according to the current situation and adjusts the duration of therapy to the client's fatigue.~Therapy will be performed by therapists with professional competence to perform hippotherapy by children with CP.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Therapeutic grooming
Description: In order to influence the psychomotor development in a comprehensive way, the psychosocial activity of therapeutic grooming will also be included in the study. Its goal is to support children's communication, their interaction with the environment, the ability to establish contact with the horse and the overall emotional support of children with SMA. The purpose of this activity is to clean the horse, its possible guide, stroking and contact with the horse, work from the ground.
Study: NCT06086808

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: General Fitness and Toning
Description: The general fitness and toning program will consist of stretching exercises, range-of-motion exercises, basic core-strengthening exercises, balance exercises, and relaxation techniques. Key balance exercises will include tandem stand, tandem walking, and single leg stance (eyes opened and closed). No additional loading (e.g., hand weights or resistance bands) will be applied to any of the exercises. This group will serve to control for confounding variables such as physical training received by traveling to the training centers, social interaction, and changes in life style secondary to study participation.
Study: NCT06231940

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Complex Decongestive Therapy (CDT) in venous insufficiency,
Description: Complex Decongestive Therapy (CDT) is a comprehensive treatment approach primarily used for lymphedema and related conditions, but it's also beneficial for chronic venous insufficiency and other edematous conditions. CDT aims to reduce swelling and maintain the reduction, improve skin condition, and alleviate symptoms. It typically involves two phases: an intensive phase to reduce swelling as much as possible and a maintenance phase to sustain the achieved results. The main components of CDT include: Manual Lymph Drainage (MLD),Compression Therapy, Exercise, Skin Care, Education and Self-Care:
Study: NCT05283538

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Coronary Artery Calcification Realization
Description: Coronary Artery Calcification Realization
Study: NCT06505005

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Drug- free, non-invasive patch (FREEDOM or REM Patch) with haptic vibrotactile trigger technology (VTT) Other Names:
Description: Drug- free, non-invasive patch (FREEDOM or REM Patch) with haptic vibrotactile trigger technology (VTT)

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Drug- free, non-invasive patch (FREEDOM or REM Patch) with haptic vibrotactile trigger technology (VTT) Other Names:
Description: Drug- free, non-invasive patch (FREEDOM or REM Patch) with haptic vibrotactile trigger technology (VTT)

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Sham Patch without haptic vibrotactile trigger technology (VTT)
Description: Sham Patch without haptic vibrotactile trigger technology (VTT)

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Patch without haptic vibrotactile trigger technology (VTT)
Description: Sham Patch without haptic vibrotactile trigger technology (VTT)
Study: NCT06339437

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: ERAS Protocol
Description: Ehanced recovery after surgery protocols were applied
Study: NCT06071936

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adezunap (AP707)
Description: Sublingual spray with maximum application of 16 actuations per day or a maximum daily dose of 17,6mg THC distributed over 4 daily intakes.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Sublingual spray with maximum application of 16 actuations per day distributed over 4 daily intakes.
Study: NCT05469685

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vonoprazan
Description: Potassium-competitive acid blocker

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vonoprazan
Description: Potassium-competitive acid blocker

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Amoxicillin
Description: Antibiotic for H. pylori eradication

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Amoxicillin
Description: Antibiotic for H. pylori eradication
Study: NCT06523153

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VYD2311
Description: Monoclonal antibody

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching Placebo
Study: NCT04980573

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aromatherapy
Description: The aromatherapy intervention consists of inhaling a fragrant oil extracted from citrus peels, plant resins, and leaves.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: The placebo intervention consists of inhaling an oil extracted from inert plant matter.
Study: NCT05572229

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Teclistamab
Description: Teclistamab will be administered via a subcutaneous injection (SC)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Teclistamab
Description: Teclistamab will be administered via a subcutaneous injection (SC)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Daratumumab
Description: Daratumumab will be administered via a subcutaneous injection (SC)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lenalidomide
Description: Lenalidomide will be administered orally
Study: NCT05240950

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anti-CEA CAR-T Cells
Description: The study will evaluate the safety of intravenous infusion of anti-CEA CAR-T (+) cells in humans at doses of 1×10\^6/kg, 3×10\^6/kg, and 6×10\^6/kg using a standard 3+3 design and preliminarily observe the efficacy.
Study: NCT05321160

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: 0.25 mg/kg esketamine for induction and 0.25 mg/kg esketamine at the beginning of surgery

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Sevoflurane
Description: 4% sevoflurane for induction and 2-4% sevoflurane for maintain
Study: NCT05697744

Intervention type: DIAGNOSTIC_TEST
Intervention: Vidiac Score
Description: Vidiac score is a scoring system created according to the visibility of laryngeal structures under videolarnyngoscopy in patients with expected difficult intubation.

Intervention type: DIAGNOSTIC_TEST
Intervention: Vidiac Score
Description: Vidiac score is a scoring system created according to the visibility of laryngeal structures under videolarnyngoscopy in patients with expected difficult intubation.
Study: NCT06404424

Intervention type: DEVICE
Intervention: Efferon LPS
Description: Efferon LPS, a medical device, which is a single-use cartridge filled with a polymeric adsorbent that selectively adsorbs endotoxin via surface-immobilized ligand and excessive cytokines via its intrinsic porosity.~This device is routinely used for extracorporeal therapy of sepsis to improve hemodynamic function and abrogate septic shock.~Plasma exchange procedures will be carried out with a replacement volume of 2 plasma volumes with fresh frozen plasma and albumin solution.~Each patient is scheduled to undergo two separate hemoperfusions lasting 8-10 hours within 48 hours.~60 minutes before the start of hemoperfusion, additional administration of antimicrobial drugs is performed, taking into account their elimination during plasma exchange and adsorption

Intervention type: DEVICE
Intervention: Efferon CT
Description: Efferon CT, a medical device, which is a single-use cartridge filled with a polymeric adsorbent that adsorbs excessive cytokines via its intrinsic porosity.~This device is routinely used for extracorporeal therapy of cytokine storm syndrome in the course of severe SARS-CoV-2.~Plasma exchange procedures will be carried out with a replacement volume of 2 plasma volumes with fresh frozen plasma and albumin solution.~Each patient is scheduled to undergo two separate hemoperfusions lasting 8-10 hours within 48 hours.~60 minutes before the start of hemoperfusion, additional administration of antimicrobial drugs is performed, taking into account their elimination during plasma exchange and adsorption
Study: NCT05596396

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: LifeHack
Description: Participants assigned to LifeHack will follow a six week-guided online intervention with a fixed structure where the themes are delivered in a predefined order, and the contents get unlocked sequentially. The first mandatory module is the introduction module which also functions as a goal-setting module. Following this, students complete one mandatory module per week (and the optional modules if they choose to do so) delivered sequentially, starting with the theme of mood, studies, social life and finally, self-esteem. Students complete the themes one by one and the consecutive themes (and modules) are unlocked only after completing the main module of the assigned theme.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: LifeHack-C
Description: Participants assigned to LifeHack-C will receive the same guided online intervention, but they can choose what theme they would like to start with, when to work on it and how many modules they wish to complete. After completing the introduction module, the participants will be advised to complete two modules per week and at least four in total. Therefore, the program's duration will be approximately two and six weeks. However, participants can follow the program at their own pace.
Study: NCT04807140

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab, nab-paclitaxel, carboplatin
Description: Patients receive Toripalimab IV on day 1, nab-paclitaxel IV on day 1 and carboplatin IV on day 1.~Treatment repeats every 21 days for up to 2-4 courses in the absence of disease progression or unacceptable toxicity.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab
Description: Patients receive Toripalimab IV on day 1.~Treatment repeats every 21 days for up to 2-4 courses in the absence of disease progression or unacceptable toxicity.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgical resection
Description: Surgical therapy will be at the discretion of the treating surgeon per standard of care.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgical resection
Description: Surgical therapy will be at the discretion of the treating surgeon per standard of care.
Study: NCT05091502

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Personalised musculoskeletal modeling
Description: Magnetic resonance images, electromyography and dynamometry data will be used to develop personalised musculoskeletal models
Study: NCT06110520

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Violet Light Lamp
Description: Medical grade lamps with Violet LEDs enabled

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Violet Light Lamp
Description: Medical grade lamps with Violet LEDs enabled

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: White Light Lamp
Description: Standard bedside lamp with standard 4000K LED light bulb.
Study: NCT06494423

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Work Support (WorkS)
Description: The WorkS intervention entails two structured visits with a research team member initiated 6-months post-HSCT, which is the earliest point at which most HSCT survivors can safely consider returning to work. The sessions are focused on 1) identifying challenges of navigating work and illness; 2) linking survivors with psychological, rehabilitative, governmental, and community resources that can promote recovery and well-being; and 3) communicating with employers regarding the necessary work modifications to achieve mutual goals.
Study: NCT04231110

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Fecal microbiota transplantation
Description: Use of fecal microbiota transplantation enemas once weekly in patients who are initiating vedolizumab treatment
Study: NCT06084429

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pre and post test (health educational intervention)
Description: The health education will be provided the following sessions.~Introduction to Global and Bangladesh Health, Health Information access (Validity), Critical Values (Vital signs, BMI, RBS etc.), Emergency Management (burn, chocking, knife cut, fainting etc.), Food (classification, healthy food, unhealthy, food label, salt intake) (NCDs from unhealthy diet), Smoking and Alcohol (NCD related, substance abuse, secondhand smoking), Physical activity (Benefits, sedentary lifestyle, NCD related), Women's health (menstruation, menstrual cycle, hygiene, STD, contraception), Hygiene (water, food, brushing, bath, toileting, healthy habits), Environmental Sanitation and Communicable disease (clean, effects on health), and Women's health and societal contribution
Study: NCT06285916

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NORA520 Dose 1
Description: Oral NORA520 tablets Dose 1 for 3 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NORA520 Dose 2
Description: Oral NORA520 tablets Dose 2 for 3 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Oral Placebo tablets for 3 days
Study: NCT05861284

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulation (TMS)
Description: Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcranial Magnetic Stimulation (TMS)
Description: Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulation (TMS)
Description: Transcranial magnetic stimulation (TMS) is a non-invasive brain stimulation method that can induce long-term changes in connections between neuronal networks.
Study: NCT05118087

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Webril Padded Plaster Splint
Description: Patients in the coaptation splint group will have a webril padded plaster splint that is placed around the humerus. The forearm and wrist are then suspended in a cuff and collar.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pre-Fabricated Fracture Brace
Description: Patients in the sarmiento group will be given a fitted pre-fabricated fracture brace with a cuff and collar for the forearm. The patients will be educated on brace maintained, tightening, and care during at the time of the ER encounter.
Study: NCT05282342

Intervention type: DIAGNOSTIC_TEST
Intervention: Diagnostic tests
Description: No intervention will be carried out. Participants of the whole groups will be underwent the same tests.

Intervention type: DIAGNOSTIC_TEST
Intervention: Diagnostic tests
Description: No intervention will be carried out. Participants of the whole groups will be underwent the same tests.

Intervention type: DIAGNOSTIC_TEST
Intervention: Diagnostic tests
Description: No intervention will be carried out. Participants of the whole groups will be underwent the same tests.

Intervention type: DIAGNOSTIC_TEST
Intervention: Diagnostic tests
Description: No intervention will be carried out. Participants of the whole groups will be underwent the same tests.