TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06406517

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gadopiclenol
Description: Gadopiclenol is an FDA-approved gadolinium-based contrast agent (GBCA) for neurological and abdominal contrast-enhanced MRI. Participants will receive this contrast agent at one of three different doses prior to undergoing a congenital heart cardiac MRI/MRA. This contrast agent will be compared to gadobenate dimeglumine, the standard-of-care.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gadopiclenol
Description: Gadopiclenol is an FDA-approved gadolinium-based contrast agent (GBCA) for neurological and abdominal contrast-enhanced MRI. Participants will receive this contrast agent at one of three different doses prior to undergoing a congenital heart cardiac MRI/MRA. This contrast agent will be compared to gadobenate dimeglumine, the standard-of-care.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gadopiclenol
Description: Gadopiclenol is an FDA-approved gadolinium-based contrast agent (GBCA) for neurological and abdominal contrast-enhanced MRI. Participants will receive this contrast agent at one of three different doses prior to undergoing a congenital heart cardiac MRI/MRA. This contrast agent will be compared to gadobenate dimeglumine, the standard-of-care.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Gadobenate dimeglumine
Description: Gadobenate dimeglumine is an FDA-approved GBCA that is used in standard clinical practice at UCSD for contrast-enhanced MRI/MRA studies, including cardiac MRI/MRA. This contrast agent is the standard of care to which gadopiclenol will be compared.
Study: NCT05690126

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Saffron extract
Description: Food supplements are taken during 6 weeks by healthy volunteers

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Maltodextrin
Description: Food supplements are taken during 6 weeks by healthy volunteers
Study: NCT05495035

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olverembatinib, APG-2575, Dexamethasone
Description: * Period 1: Subjects will orally take olverembatinib 40mg adult equivalent dose alone QOD from Day 1 to Day 14 (D1 - D14) =. The investigator may start the combination therapy in advance based on medical conditions of the subjects, but not earlier than Day 5/the third dose (D5).~* Period 2: 1) Subjects will orally take olverembatinib 40mg adult equivalent dose QOD from Day 15 to Day 42 (D15 - D42)).~  2) Subjects will orally take APG-2575 at a ramp up 200mg/400mg/600mg adult equivalent dos QD from D13 to D42 at a dose . In addition, a 3-day dose escalation from D13 to D15 will be needed, and the designated reference dose will be reached on D15.~  3) Subjects will orally take dexamethasone 6 mg/m2/day, QD from D15 to D42 at 6 mg/m2/day.
Study: NCT05322278

Intervention type: OTHER
Intervention: Data collection
Description: No interventions

Intervention type: OTHER
Intervention: Data collection
Description: No interventions

Intervention type: OTHER
Intervention: Data collection
Description: No interventions
Study: NCT06411301

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 225Ac-DOTATATE
Description: Two intravenous infusions every 6 weeks (Q6W)
Study: NCT06419569

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional physical therapy
Description: the patients will receive conventiobal physical therapy in the form of Exercise therapy program (1) Warm-up exercises: Walking at the usual speed on a flat surface for 10 min with hamstring and calf gentle stretches.(2) Major exercises for knee OA: Straight leg raise, quadriceps setting, heel raise, one leg balance, step ups, and quadriceps strengthening exercises. The US protocol consists of continuous ultrasonic waves of 1 MHz frequency and 1 W/cm2 intensity applied with a 5-cm diameter applicator. The patients will be placed in a supine position, and the US applied to the medial and lateral parts (5 min on each side) of the knee in circular movements with the probe at right angles to ensure maximum absorption of the energy.
Study: NCT06336473

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: skin biopsy
Description: Samples will be taken under local anaesthetic (after injection of 1 cc of Xylocaine without adrenaline) using a 4 mm diameter dermal biopsy punch. The biopsy will be performed on the buttocks. Fragments are stored in 15-mL polypropylene tubes in PBS at 4°C.
Study: NCT05753670

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tamsulosin
Description: Subjects randomized to the experimental arm will receive a single dose of 0.4mg Tamsulosin tablet in the preoperative holding area prior to their scheduled mid-urethral sling placement in the operating room.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subjects randomized to the control arm will receive a single dose of a placebo tablet in the preoperative holding area prior to their scheduled mid-urethral sling placement in the operating room.
Study: NCT05555368

Intervention type: OTHER
Group type: OTHER
Intervention: Quality of Recovery Score
Description: Descriptive
Study: NCT05485935

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Investigational device - intermittent catheter with micro-hole zone
Description: Intermittent male catheter with micro-hole zone for urinary drainage

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Comparator - standard intermittent catheter
Description: SpeediCath Flex, VaPro Pocket, VaPro Plus and VaPro Plus Pocket.
Study: NCT05938166

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: oral care augmented reality (AR)
Description: Augmented reality (AR) is an extension of perceptible reality, whereby additional information, such as texts or virtual objects, can be displayed in the user's field of vision.The oral care augmented reality (AR) simulation training can train foreign care workers by switching languages (Indonesian) and therefore reduce language-related learning barriers.
Study: NCT06118827

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-10518
Description: QD, orally for 7 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-10518
Description: QD, orally for 7 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-10518
Description: QD, orally for 7 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-10518
Description: QD, orally for 7 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: QD, orally for 7 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: QD, orally for 7 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: QD, orally for 7 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: QD, orally for 7 days
Study: NCT05142566

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MANTA Vascular Closure Device
Description: Evaluate the safety of ultrasound guided deployment of MANTA VCD.
Study: NCT04945954

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Drug: Cyclophosphamide
Description: Administer 14.5mg/kg of Cyclophosphamide once a day for 4days. (intravenously)~Blood sampling of pharmacokinetics(PK) of cyclophosphamide will be performed in all patients who have taken the investigational drug for at least 4 days (For 2 days, It will be administered for pretreatment of transplant, for the other 2 days, It will be administered for Post-transplant treatment for the prevention of GVHD)
Study: NCT04532970

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cessation Counseling
Description: Two different types of smoking cessation counseling
Study: NCT05181332

Intervention type: OTHER
Intervention: Prediction model
Description: Clinical models were developed and validated to predict liver-related complications and survival outcomes in pediatric patients with biopsy-proven with cirrhosis.

Intervention type: OTHER
Intervention: Prediction model
Description: Clinical models were developed and validated to predict liver-related complications and survival outcomes in pediatric patients with biopsy-proven with cirrhosis.
Study: NCT04532970

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Cessation Counseling
Description: Two different types of smoking cessation counseling
Study: NCT05998044

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pilates Based Exercises
Description: The average application time of the exercises is 30-40 minutes (with the first 10 minutes of warming up and the last 5 minutes of stretching). The first four exercises were used for the warm-up period and the last four exercises were used for the stretching period. The exercises will be done as 1 set of 8 repetitions. The Hundred exercise will be increased to 10 sets of 10 reps every two weeks to 10 reps, 12 reps, and 14 reps, respectively. Participants will be asked to open the video recording each time they exercise and follow them to do the exercises.~Exercise Program:~* Arm Circles~* Toe Touch~* bridge~* Shoulder Bridge~* Chest Lift~* Hundred~* Roll Up~* Leg Circles~* Chris Cross~* Side Kick~* Side Leg Circles~* one leg kick~* double leg kick~* Swan~* Single leg Stretch~* Double leg Stretch~* saw~* Spine Stretch

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: control
Description: They will be asked not to participate in any regular exercise for 8 weeks.
Study: NCT05545709

Intervention type: PROCEDURE
Intervention: remote robot-assisted spine surgery
Description: Based on the 5G network, the orthopedic robotic remote surgery platform is built at Beijing Jishuitan Hospital, providing primary hospitals with a platform for preoperative consultation, intraoperative communication and surgical robot teleoperation, and postoperative follow-up. With the support of the 5G network, equipment and surgical robots are integrated into the remote surgery service platform, building a high-speed transmission channel between Beijing Jishuitan Hospital and other hospitals.
Study: NCT06267105

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Longitudinal incision
Description: Incision performed longitudinally

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Transverse incision
Description: Incision performed transversally
Study: NCT06489366

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Thulium Fiber laser (TFL) lithotripsy
Description: Patients with proximal ureteral stones undergoing ureteroscopic lithotripsy using thulium laser lithotripsy.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Ho: YAG lithotripsy
Description: Ho:YAG laser lithotripsy was used in patients with proximal ureteral stones undergoing ureteroscopic lithotripsy.
Study: NCT05964569

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: model-guided optimization of treatment plan
Description: original treatmant plans are optimized based on model-based NTCP

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: standard treatment plan, no optimization
Description: original treatment plans are not optimized
Study: NCT06344637

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 10 % lidocaine spray without adrenaline
Description: Pateint with indication for manual vacuum aspiration aged between 20-60 years will received a standard injection of pethidine along with 1% lidocaine spray without adrenaline on cervical os to compare pain scores with placebo. Along with measuring side effects immediately and 30 minutes after receiving 1% lidocaine without adrenaline.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 4 puffs of normal saline apply on cervical os before manual vacuum aspiration
Study: NCT04159077

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tamsulosin Hydrochloride
Description: Tamsulosin HCL is an alpha blocker. It relaxes the muscles in the prostate and bladder neck, making easier to urinate. The dosage used will be 0.4 mg (administered once daily)~Other names: Flomax

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebos
Description: Half of the patients will be assigned to receive placebo tablets in the same manner as the active intervention. These tablets will have no effect.
Study: NCT06157021

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rotary pulpectomy
Description: Pulpectomy procedures by making cleaning and shaping of root canals of necrotic primary molars using (Fanta AF baby\* rotary files and Endo Radar\* rotary device).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Manual pulpectomy
Description: Pulpectomy procedures by making cleaning and shaping of root canals of necrotic primary molars using Manual H files, Mani\*)
Study: NCT04966325

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LC350189 200mg
Description: Subject will receive an LC350189 200mg as single-dose on Day 1(Period 1) or Day 5(Period 2) or Day 9(Period 3) or Day 13(Period 4)

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subject will receive a Placebo as single-dose on Day 1(Period 1) or Day 5(Period 2) or Day 9(Period 3) or Day 13(Period 4)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Moxifloxacin 400mg
Description: Subject will receive a Moxifloxacin 400mg as single-dose on Day 1(Period 1) or Day 5(Period 2) or Day 9(Period 3) or Day 13(Period 4)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LC350189 600mg
Description: Subject will receive an LC350189 600mg as single-dose on Day 1(Period 1) or Day 5(Period 2) or Day 9(Period 3) or Day 13(Period 4)
Study: NCT03569124

Intervention type: OTHER
Intervention: Teaching tool for identification of colorectal polyps
Description: This is a teaching session on how to identify the colorectal polyps shot in blue light imaging.
Study: NCT05962957

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: carbidopa-levodopa
Description: Levodopa is typically prescribed to a patient with Parkinson disease once symptoms become more difficult to control with other anti-parkinsonism drugs. The drug can also be used for postencephalitic parkinsonism and symptomatic parkinsonism due to carbon monoxide intoxication

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: carbidopa-levodopa
Description: Levodopa is typically prescribed to a patient with Parkinson disease once symptoms become more difficult to control with other anti-parkinsonism drugs. The drug can also be used for postencephalitic parkinsonism and symptomatic parkinsonism due to carbon monoxide intoxication

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: carbidopa-levodopa
Description: Levodopa is typically prescribed to a patient with Parkinson disease once symptoms become more difficult to control with other anti-parkinsonism drugs. The drug can also be used for postencephalitic parkinsonism and symptomatic parkinsonism due to carbon monoxide intoxication

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pentoxifylline 400 MG
Description: Pentoxifylline (PTX) has a well validated immune modulatory and anti-inflammatory efficacy via suppression of the TLR4/NF-κB network signaling pathway. Moreover, Pentoxifylline has a potential antioxidant capacity mostly via nuclear erythroid 2-related factor 2 (Nrf2) activation with subsequent up-regulation and expression of several antioxidant enzymes

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Celecoxib 200mg
Description: Celecoxib is a nonsteroidal anti-inflammatory drug (NSAID) used to treat mild to moderate pain and help relieve symptoms of arthritis
Study: NCT04923438

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Telerehabilitation
Description: The exercise program will begin with a warm-up, followed by a stretching exercise and an alphabetical exercise game called what's your name, and will end with a cool-down. The exercises will be performed 2 times a week for a total of 12 weeks, and each program will last for roughly 30 minutes. it will last. In what is your name game, 10 5-letter words containing the whole alphabet were produced and children will work out the exercises corresponding to each letter with a word they choose for each day.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: The same exercise program will be prepared and given to the patients who are offered and not accepted telerehabilitation, and they will be asked to do their own exercises at home. This group will also be included in the study as a control group.
Study: NCT05905536

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Vitalstream
Description: The device will be placed on the subject and monitoring started in the holding room on the morning of surgery. Monitoring will continue postoperatively until the pulmonary artery catheter (PAC) is removed (Standard of Care) or discharged, or at study team discretion. At Intensive Care Unit (ICU) admittance and again 3 hours later a straight leg raise will be done to monitor for changes in hemodynamics.
Study: NCT05667844

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: interoceptive mind-body exercise
Description: A interoceptive mind-body exercise program in a patient with Generalized Anxiety Disorder and Major Depressive Disorder based on a Multidimensional Assessment of Interoceptive Awareness. Each session of the body-mind intervention lasts 80 minutes and is supervised by physical education professionals. The intervention is divided in 4 parts, that are: Preparatory phase (reception) the subjects will be welcomed through subjective analyzes of the researcher; Initial phase (preliminares) Mindfulness, grounding, sensory stimulation and joint warm-up exercises are performed; main phase (exercises) stretching, mobility, posture and balance exercises are performed with full attention and listening after each exercise; Final phase (relaxation) breathing exercises, stretching exercises, body scanning and relaxation are performed.
Study: NCT06505304

Intervention type: PROCEDURE
Intervention: Colonoscopy
Description: The colonoscopy will be performed at 3 or 6 months after surgery according to FC:~* In patients with FCP \>=150µg/g at around 3 months after surgery, a colonoscopy will be immediately performed~* In patients with FCP \<150µg/g at around 3 months after surgery, the colonoscopy will be organized at 6 months after surgery~Colonoscopy will be performed using high definition white-light endoscopy (HD-WLE) followed by virtual chromoendoscopy (VCE). The neoterminal ileum, ileocolic anastomosis and right colon will be assessed.~A follow-up colonoscopy will be performed within 18 months after index colonoscopy, as standard of care.

Intervention type: PROCEDURE
Intervention: Intestinal biopsies
Description: During index colonoscopy, at least 2 biopsies from each of the segments will be taken as standard of practice to assess inflammation in post-operative CD. Only in Irish sites, twelve biopsies - four in the area of ileocolonic anastomosis, four in the neo-terminal ileum and four in the colon just distal to the anastomosis- will be taken for research purposes, in addition to standard-of-care biopsies.

Intervention type: PROCEDURE
Intervention: Confocal laser endomicroscopy
Description: pCLE with fluorescein injection will be performed during index colonoscopy, in centres where is available, to assess early alteration of the barrier function.

Intervention type: PROCEDURE
Intervention: Intestinal ultrasound
Description: All patients will undergo a cross-sectional imaging test as part of their standard of care at 3 and 6 months after surgery. A follow-up IUS will be performed within 18 months after index colonoscopy, as standard of care.

Intervention type: DIAGNOSTIC_TEST
Intervention: Stool
Description: Stool samples will be collected at 3 and 6 months after surgery and used for faecal calprotectin analysis. Research stool will be collected during the visit of index colonoscopy and at 12 months after index colonoscopy for metagenomics (only in Irish sites).
Study: NCT06485986

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: DBS on/off
Description: DBS will be turned on and off for experimental periods to compare the effect of DBS on behaviour.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: DBS on/off
Description: DBS will be turned on and off for experimental periods to compare the effect of DBS on behaviour.
Study: NCT04957420

Intervention type: DRUG
Intervention: Neupro
Description: Rotigotine Patches
Study: NCT04184661

Intervention type: OTHER
Intervention: blood sample
Description: 25 mL blood sample will be collected on citrate tubes for osteoclastic analysis.
Study: NCT05859048

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: NT-proBNP
Description: blood sample to measure N-terminal prohormone of B-type natriuretic peptide at local laboratory

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: AI echocardiogram
Description: Artificial intelligence driven transthoracic echocardiogram

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: electrocardiogram
Description: tracing of electrical cardiac activity of the heart

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Cardiovascular physical examination
Description: basic physiological measurements to include height (cm), weight (kg) and hip circumference (cm) and blood pressure (mmHg)
Study: NCT06456944

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: stretching exercises
Description: stretching exercises of the plantar fascia, gastrocnemius and soleus

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: stretching exercises
Description: stretching exercises of the plantar fascia, gastrocnemius and soleus

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ultrasound
Description: therapeutic ultrasound upon the most painful point on the medial calcaneal tubercle. The parameters involved a pulsed mode (duty cycle 50%) using an intensity of 1.5 W/cm2 and a 1 MHz of frequency for 5 minutes

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: rigid tape
Description: low-dye tapping will be done to provide mechanical correction to plantar fascia and medial longitudinal arch

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mobilization
Description: mobilization techniques for the talocrural joint in weight bearing and non-bearing positions and subtalar joint

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mobilization
Description: mobilization techniques for the talocrural joint in weight bearing and non-bearing positions and subtalar joint

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: myofascial release
Description: deep tissue release of the plantar fascia and flexor hallucis longus in a stretched position of the plantar fascia

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: strengthening exercise
Description: strengthening exercise of the plantar intrinsic muscles using short foot exercise and strengthening of the Achilles tendon and windlass mechanism using unilateral heel raise exercises