TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05050916

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Vitamin D
Description: This is a Phase II randomized, dose-ranging clinical trial including 1) a within-woman comparison of hormones pre-and post-supplementation and 2) a comparison across women on a Vitamin D and a placebo. After recruitment, there will be two phases: Phase 1 will follow all women for one menstrual cycle prior to supplementation; blood will be assayed for 25OHD. Phase 2 includes only: 1) women with less than 20 ng/ml 25OHD (deficient) OR 2) a sample of women with \>20 ng/ml 25OHD (sufficient) as the placebo group. During Phase 2, deficient women will be assigned to receive a blinded dose of 50,000 IU of vitamin D supplementation per week and followed for three more menstrual cycles. Hormone levels will be compared between the pre-and post-supplementation cycles as the primary analysis. The primary aim will test: if mid-luteal progesterone, rate of estrogen rise and pre-ovulatory LH are higher in vitamin D supplemented cycles.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Vitamin D
Description: This is a Phase II randomized, dose-ranging clinical trial including 1) a within-woman comparison of hormones pre-and post-supplementation and 2) a comparison across women on a Vitamin D and a placebo. After recruitment, there will be two phases: Phase 1 will follow all women for one menstrual cycle prior to supplementation; blood will be assayed for 25OHD. Phase 2 includes only: 1) women with less than 20 ng/ml 25OHD (deficient) OR 2) a sample of women with \>20 ng/ml 25OHD (sufficient) as the placebo group. During Phase 2, deficient women will be assigned to receive a blinded dose of 50,000 IU of vitamin D supplementation per week and followed for three more menstrual cycles. Hormone levels will be compared between the pre-and post-supplementation cycles as the primary analysis. The primary aim will test: if mid-luteal progesterone, rate of estrogen rise and pre-ovulatory LH are higher in vitamin D supplemented cycles.
Study: NCT05391477

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: GI-Genius artificial intelligence
Description: The software allows for the real-time characterization of framed polyps during a colonoscopy classifying them on adenoma or non-adenoma.
Study: NCT04761302

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Use of non-steroid anti-inflammatory drugs (NSAIDS) as an alternative for post-operative pain management after a femur and tibia fracture
Description: This is a randomized controlled, single blind, parallel groups, opioid control trial of all patients (total of 150 patients) who suffered tibial and femoral shaft fractures and were treated with intramedullary nailing. Patients will be aleatory assigned to two study groups: Group-1 will receive non-opioid medications, and Group-2 will receive opioid medications. During the inpatient postoperative period, patients will undergo subjective evaluation of pain utilizing a previously validated questionnaire, the Visual Analogue Score (VAS). The first questionnaire will be completed twelve hours after surgery and during subsequent twelve-hour intervals until discharge. Secondary outcomes will include efficiency such as time to gastrointestinal motility, time to weight bearing of affected limb, resumption of ambulation, and length of hospital stay. The evaluation will take approximately 15 minutes to complete each time, we the entire participation time to be 60 minutes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Use of non-steroid anti-inflammatory drugs (NSAIDS) as an alternative for post-operative pain management after a femur and tibia fracture
Description: This is a randomized controlled, single blind, parallel groups, opioid control trial of all patients (total of 150 patients) who suffered tibial and femoral shaft fractures and were treated with intramedullary nailing. Patients will be aleatory assigned to two study groups: Group-1 will receive non-opioid medications, and Group-2 will receive opioid medications. During the inpatient postoperative period, patients will undergo subjective evaluation of pain utilizing a previously validated questionnaire, the Visual Analogue Score (VAS). The first questionnaire will be completed twelve hours after surgery and during subsequent twelve-hour intervals until discharge. Secondary outcomes will include efficiency such as time to gastrointestinal motility, time to weight bearing of affected limb, resumption of ambulation, and length of hospital stay. The evaluation will take approximately 15 minutes to complete each time, we the entire participation time to be 60 minutes.
Study: NCT04733742

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: rhTNK-tPA
Description: intravenous thrombolysis with rhTNK-tPA followed by endovascular treatment

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Endovascular treatment
Description: endovascular treatment

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Endovascular treatment
Description: endovascular treatment
Study: NCT06475443

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: pyrotinib plus capecitabine
Description: oral
Study: NCT05873426

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [14C] ZSP1273
Description: 600 mg suspension containing 50μCi of \[14C\]ZSP1273
Study: NCT05206019

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Albuvirtide
Description: Long-Acting HIV-1 Fusion Inhibitor (chemically modified peptide targeting HIV-1 gp41)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Albuvirtide
Description: Long-Acting HIV-1 Fusion Inhibitor (chemically modified peptide targeting HIV-1 gp41)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Albuvirtide
Description: Long-Acting HIV-1 Fusion Inhibitor (chemically modified peptide targeting HIV-1 gp41)
Study: NCT01452698

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: TAK-438 placebo-matching tablets, orally, once daily for up to 8 weeks.
Study: NCT05399043

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Multidisciplinary Conventional Neuromotor Rehabilitation
Description: Patients will receive conventional treatment consisting of two daily one-hour session (4 weeks) and including traditional rehabilitation activities like range of motion exercises (passive, active assisted and active), progressive resistive exercises, balance and strength training, and aerobic conditioning. The intervention procedures will follow the routine multidisciplinary clinical practice of the Institute where the study will be carried out. Procedures will be adapted according to patient's medical diagnosis, disability severity, and to the consequent rehabilitation objectives in favor of an individualized rehabilitation project and program. If necessary, patients might therefore undergo parallel rehabilitation activities (ie, occupational therapy, speech therapy, cognitive stimulation) that will be kept under control throughout data collection and analyses.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multidisciplinary Conventional Neuromotor Rehabilitation
Description: Patients will receive conventional treatment consisting of two daily one-hour session (4 weeks) and including traditional rehabilitation activities like range of motion exercises (passive, active assisted and active), progressive resistive exercises, balance and strength training, and aerobic conditioning. The intervention procedures will follow the routine multidisciplinary clinical practice of the Institute where the study will be carried out. Procedures will be adapted according to patient's medical diagnosis, disability severity, and to the consequent rehabilitation objectives in favor of an individualized rehabilitation project and program. If necessary, patients might therefore undergo parallel rehabilitation activities (ie, occupational therapy, speech therapy, cognitive stimulation) that will be kept under control throughout data collection and analyses.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Technology-based Rehabilitation
Description: According to their individualized rehabilitation project, patients will undergo RAT or non-immersive VR-based rehabilitation.~RAT will consist of three times a week one-hour session (4 weeks) and will be conducted by the implementation of an exoskeleton device for the upper limbs (Armeo-Spring™) or for the lower limbs (Lokomat™).~VR-based rehabilitation will consist of one daily one-hour session (4 weeks) and will be conducted by the implementation of a single non-immersive VR device among the Riablo™ (Corehab, Italy), the ProKin 252™ (TechnoBody SRL, Italy), the D-Wall™ (TechnoBody SRL, Italy), the Walker View™ (TechnoBody SRL, Italy).~Part of the duration of the whole treatment will be dedicated to the use of the device, resulting in the same amount of rehabilitation for all participants.
Study: NCT06256406

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: in the field of rehabilitation and neonatal care: the combination of Kangaroo care method and music therapy
Description: Kangaroo care is a practice involving skin-to-skin contact between the infant and a caregiver,. Music therapy is a therapeutic approach that utilizes the expressive and emotional qualities of music to address physical, emotional, cognitive needs of individuals.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: in the field of rehabilitation and neonatal care: the combination of Kangaroo care method and music therapy
Description: Kangaroo care is a practice involving skin-to-skin contact between the infant and a caregiver,. Music therapy is a therapeutic approach that utilizes the expressive and emotional qualities of music to address physical, emotional, cognitive needs of individuals.
Study: NCT06110026

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Brunkow Exercise Program
Description: The brunkow exercise program will be comprised of four exercise programs. Each exercise will be performed with two sets of 15 reps, 10 sec per rep 40 min per day, thrice per week for a total of four weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Lumbar Stabilization Exercises
Description: The lumbar stabilization exercises will be comprised of four exercise programs. Each exercise will be performed with two sets of 15 reps, 10 sec per rep 40 min per day, thrice per week for a total of four weeks.
Study: NCT06469034

Intervention type: DEVICE
Group type: OTHER
Intervention: conventional ultrasound
Description: The operators in the control group will perform the procedure by visualizing the conventional ultrasound images displayed directly on the ultrasound screen. Each operator will perform an internal jugular vein cannulation via the short-axis approach. To standardize the approach, the ultrasound machine will be placed just to the right of the patient and operators will be asked to stand at the head of the patient and perform the procedure on the patient's internal jugular vein. Each operator could determine the height of the surgical table, and the posture during the procedure that will be most familiar to him/her to increase the success rate. Every procedure will be recorded by focusing on the participant's hands and faces.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Mixed reality and head-mounted display ultrasound
Description: In the MR + HMD group, the ultrasound machine will be located behind the operator to remove the distraction, and the operator will not be allowed to see the ultrasound screen during the procedure. The operators randomized into the MR+HMD group will use a MR ultrasound machine. Images from the MR ultrasound machine will be transmitted to HMD via a novel connection developed specifically for this purpose. The operator will wear a pair of HMD and perform the procedure by visualizing the ultrasound images displayed on their HMD screen instead of the ultrasound screen. Each operator will perform an internal jugular vein cannulation via the short-axis approach. Every procedure will be recorded by focusing on the participant's hands and faces.
Study: NCT04862871

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Physical Activity - Pediatric Pain Rehabilitation Center
Description: While admitted to the Pediatric Pain Rehabilitation Center program, patients receive 1-3 hours of individual and group physical therapy 5 times per week and completed a 30-60 minute home exercise program 9 times per week. The median length of stay for the program is 5 weeks. The amount of aerobic exercise prescribed is individualized to each patient and ranged from 10-20 minutes per session. The duration of aerobic exercise prescribed progressed by 5-10 min weekly until the child reached 20-30 minutes. Patients are instructed to reach a moderate to vigorous intensity of exercise (defined at 5-7/10 rate of perceived exertion). The mode of exercise varied dependent on patient ability and interest. Typical modes of exercise included: walking, running, stationary biking, swimming, sports (i.e., soccer, dance), and online aerobic workouts. Patients were prescribed an individualized 30-60 minute discharge home program using the same structure upon completing the program.
Study: NCT06110325

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cawthorne and Cooksey exercise program
Description: Participants in this group will receive an exercise program based on Cawthorne and Cooksey exercises. The intervention will last for 4 weeks, taking place three times a week, with the first session conducted in person and the remaining two assisted via video from their homes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: Control group will receive counseling focused on fall prevention and promotion of an active, healthy lifestyle through informational leaflets.
Study: NCT05615090

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Arm I (Prepectoral),
Description: The intervention will be delivered through a smartphone app. The app provides users with ED symptom self-monitoring, psycho-education and relapse prevention in an evidence-based CBT-E.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Arm II (Subpectoral)
Description: The intervention will be delivered through a smartphone app. The app provides users with ED symptom self-monitoring, psycho-education and relapse prevention in an evidence-based CBT-E.
Study: NCT06521320

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: speaking valve combined with airway pressure
Description: All patients were given speaking valves and airway pressure was measured to assess upper airway patency.
Study: NCT05504863

Intervention type: DRUG
Intervention: Ferric carboxymaltose
Description: As part of the RAPIDIRON Trial, maternal participants randomized to intervention arm 1 were given a single dose of ferric carboxymaltose between 14 and 17 weeks of pregnancy.

Intervention type: DRUG
Intervention: Iron isomaltoside
Description: As part of the RAPIDIRON Trial, maternal participants randomized to intervention arm 2 were given a single dose of iron isomaltoside between 14 and 17 weeks of pregnancy.

Intervention type: DRUG
Intervention: Ferric Sulfate
Description: As part of the RAPIDIRON Trial, maternal participants randomized to the active comparator arm were given 200 ferrous sulfate tablets immediately after randomization (\~12 weeks of pregnancy). Participants were instructed to take two tablets a day, with each tablet containing 60mg elemental iron.
Study: NCT06115551

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Fasting Mimicking Diet
Description: FMD is a 5-day low calorie fasting-mimicking diet.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Fasting Mimicking Diet
Description: FMD is a 5-day low calorie fasting-mimicking diet.
Study: NCT01114061

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Insupatch
Description: Applying heat to the infusion site using the insupatch device
Study: NCT05446688

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 6MW3211
Description: 6MW3211 injection, 45mg/kg, Q2W
Study: NCT05755360

Intervention type: DRUG
Intervention: Semaglutide
Description: Participants will be treated with commercially available oral semaglutide according to routine clinical practice at the discretion of the treating physician. The decision to switch from DPP4i treatment to oral semaglutide is at the discretion of the treating physician and is clearly independent from the decision to include the participant in the study.
Study: NCT06521320

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: speaking valve combined with airway pressure
Description: All patients were given speaking valves and airway pressure was measured to assess upper airway patency.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Bronchoscopy
Description: The same examiner performed bronchoscopy on all patients to assess upper airway patency.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Bronchoscopy
Description: The same examiner performed bronchoscopy on all patients to assess upper airway patency.
Study: NCT05975203

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: skin-to-skin contact
Description: Immediately after delivery the infant will receive skin-to-skin contact with the mother.
Study: NCT04662489

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Pulmonary vein electrical isolation
Description: Electrical isolation of the pulmonary veins from the left atrium with cryoablation therapy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radial ablation
Description: Electrical isolation of the pulmonary veins from the left atrium plus radial ablation of rotational activity sites with radiofrequency ablation.
Study: NCT05397951

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Multi-modality Noninvasive Biosensor
Description: The wearable sensor devices will be placed on the finger, wrist, temple, subclavian, arm, neck, and thigh of the participant and will provide continuous tissue mechanics, heart rate, respiration rate, blood flow, and pulse oxygenation measurements continuously throughout the experimental period.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Multi-modality Noninvasive Biosensor
Description: The wearable sensor devices will be placed on the finger, wrist, temple, subclavian, arm, neck, and thigh of the participant and will provide continuous tissue mechanics, heart rate, respiration rate, blood flow, and pulse oxygenation measurements continuously throughout the experimental period.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Oximeter
Description: The oximeter device will be placed on the right middle finger of the participant and will provide continuous pulse oxygenation and heart rate measurements continuously throughout the experimental period.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Oximeter
Description: The oximeter device will be placed on the right middle finger of the participant and will provide continuous pulse oxygenation and heart rate measurements continuously throughout the experimental period.
Study: NCT05158582

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: SPECIFIC MODIFIED EXERCISE PROGRAM GROUP
Description: The modified exercise program group will perform following exercises:~Resisted static Squats SLER Banded rows SL Banded Jumps Resisted explosive reverse lunges 5hurdle Jumps Elevated single leg Swiss ball Bosu Banded Stars RLE Barbell lunge Static shoulder Abd.with banded leg Add Ant.Banded static squat with medball press Bosu banded superman Sit ups

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: CONVENTIONAL EXERCISES PROGRAM GROUP
Description: The conventional exercise program group will perform the same exercises as they doing for their low back pain.
Study: NCT06323577

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Restricted kinematic alignment
Description: TKA using restricted kinematic alignment under robotic assisted surgery (MAKO).

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mechanical alignment
Description: TKA using mechanical alignment under robotic assisted surgery (MAKO).
Study: NCT04984525

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYNB1934
Description: SYNB1934 is formulated as a nonsterile solution intended for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYNB1934
Description: SYNB1934 is formulated as a nonsterile solution intended for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYNB1934
Description: SYNB1934 is formulated as a nonsterile solution intended for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYNB1934
Description: SYNB1934 is formulated as a nonsterile solution intended for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYNB1934
Description: SYNB1934 is formulated as a nonsterile solution intended for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYNB1934
Description: SYNB1934 is formulated as a nonsterile solution intended for oral administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SYNB1618
Description: SYNB1618 is formulated as a nonsterile solution intended for oral administration
Study: NCT04664439

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: CT-FFR
Description: CCTA examination will be performed by qualified medical imaging technicians, and patients will be scanned with 256rows of CT, according to standard operating norms. The coronary artery physiological function evaluation software(Keya Medical Technology, Beijing, China)will be configured in the core laboratory in advance, and the relevant imaging analysts will be trained. The core laboratory will receive the CCTA inspection data and evaluate the CCTA image quality. According to the standard operation flow of the software specification, the CT-FFR analysis will be carried out on the images that meet the requirements, and the CT-FFR value of the lesions will be measured.
Study: NCT05397951

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Portable Blood Pressure Monitor
Description: The blood pressure monitor device will be placed on the left arm of the participant and will take a blood pressure measurement every 5 minutes throughout the 15 minute experimental period, and every 15 minutes throughout the 2 hour experimental period.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Portable Blood Pressure Monitor
Description: The blood pressure monitor device will be placed on the left arm of the participant and will take a blood pressure measurement every 5 minutes throughout the 15 minute experimental period, and every 15 minutes throughout the 2 hour experimental period.