TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05797519

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: VDyne Transcatheter Tricuspid Valve Replacement System
Description: The study investigational device is the VDyne Transcatheter Tricuspid Valve Replacement System.
Study: NCT06559878

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Normal Saline
Description: Normal saline is given intravenously during one metabolic visit.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Normal Saline
Description: Normal saline is given intravenously during one metabolic visit.
Study: NCT06352645

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Bixdo Ultra Compact Water Flosser
Description: Use of water flosser, in addition to standard tooth brushing, twice a day for 8 weeks.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Manual toothbrush
Description: For those in the control group, they will be asked to use only the study-provided manual toothbrush, twice a day for 8 weeks.
Study: NCT05847478

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Auricular acupressure of traditional Chinese Medicine
Description: The participants will be randomly assigned to receive the auricular point patch therapy.~The selected acupoints include Shenmen, hungry point, endocrine, stomach, mouth and subcortical. The opaque patch with vaccaria seed is used for acupoint pressing. Pressing the acupoints once a day before and after eating, each time for 1 minute, lasting for 2-3 days, follow up visit once a week. The intervention period is 3 months.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intermittent low carbohydrate diet
Description: The participants will be randomly assigned to the intermittent low carbohydrate diet group.~The intermittent carbohydrate diet includes 7 days of low carbohydrate diet within 2 weeks (consecutive or nonconsecutive, carbohydrate intake be controlled as ≤ 50g per day). The study duration is 3 months, including 1-month intervention period and 2-month self-maintenance period.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health education
Description: Health education is conducted once a week during 3-month intervention for all participants. Health education including the understanding of childhood obesity and cardiovascular disease, how to determine the cardiometabolic risk level, and the lifestyle intervention as caloric restriction and increased physical activity to promote health.
Study: NCT06563037

Intervention type: OTHER
Intervention: No intervention
Description: This is an observational study
Study: NCT05847478

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health education
Description: Health education is conducted once a week during 3-month intervention for all participants. Health education including the understanding of childhood obesity and cardiovascular disease, how to determine the cardiometabolic risk level, and the lifestyle intervention as caloric restriction and increased physical activity to promote health.
Study: NCT06284941

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ropivacaine combined with methylene blue for iliac fascia block
Description: Ultrasound guided iliac fascia block, administered with 30ml of 0.25% ropivacaine+0.05% methylene blue
Study: NCT05007730

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Transitional-state food therapeutic nutrition supplement
Description: Participants will consume at least one snack-sized package of the transitional-state food supplements per day across the intervention trial.
Study: NCT06498128

Intervention type: DRUG
Intervention: Daridorexant
Description: Dosing and treatment duration of QUVIVIQ as part of this observational study is at the discretion of the healthcare provider in accordance with local clinical practice and local labeling.

Intervention type: DRUG
Intervention: Non-orexin receptor antagonist medications for insomnia
Description: Dosing and treatment duration of non-orexin receptor antagonist medications for insomnia as part of this observational study is at the discretion of the healthcare provider in accordance with local clinical practice and local labeling.

Intervention type: OTHER
Intervention: No insomnia medication
Description: No insomnia medication was administered.
Study: NCT05649072

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Genetic Testing and Counseling
Description: Participants will be asked to collect a saliva sample for hereditary cancer and genetic testing

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Screening Form
Description: Participant will be answering demographic details
Study: NCT06458153

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Neural responses to speech functional localizer
Description: Measuring speech-related brain activity using fMRI during a speech listening task.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Neural responses to silent articulation
Description: Measuring speech-related brain activity using fMRI during a silent articulation task.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Neural responses to self vs. externally generated speech
Description: Measuring speech-related brain activity using fMRI during self-generated vs. externally-generated speech.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Event-related potentials for speech
Description: Measuring electroencephalography (EEG) based evoked potentials for self vs. externally generated speech

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Neural responses to induced speech errors
Description: Measuring speech-related brain activity using fMRI during conditions that induce auditory speech errors.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Neural responses to sensory-motor adaptation
Description: Measuring brain activity using fMRI during a learning task with sustained altered auditory feedback.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Speech production behaviors
Description: Behavioral measurements of speech during reading passages and words

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Auditory acuity testing
Description: Measurements of auditory acuity during listening tasks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Neural responses to learning a non-speech auditory motor behavior
Description: Mapping of brain areas using fMRI during learning of non-speech sound-evoking movements.
Study: NCT06608966

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Epilepsy Journey web-based modules
Description: Participants assigned to Epilepsy Journey modules will independently review web-based EJ modules focused on executive functioning skills. The modules cover 10 topic areas: Positive Thoughts, Problem-Solving, Initiation, Working Memory, Monitoring, Inhibition, Emotional Control, Organization and Planning, Sleep/Stress, and a Wrap-Up. Participants will complete 10 modules (\~15-30 minutes each session) within a 14-week time frame. The goal is to complete one module per week.
Study: NCT04849390

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ESO-101
Description: Daily administration in the evening at bedtime for 28 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Daily administration in the evening at bedtime for 28 days
Study: NCT06209749

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sensory-based intervention module
Description: Consists of sensory-based activities (Set A-F) with six weeks of individual sessions and six weeks of group sessions
Study: NCT06425562

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Full lung function
Description: This includes spirometry, body plethysmography and single breath gas transfer test. These are all non-invasive physiological measurements / lung function tests. Measures flow volumes, lung volumes and gas transfer respectively.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Multiple breath nitrogen washout
Description: Non-invasive physiological measurement / lung function test. 100% oxygen is inhaled and the nitrogen concentration in the lungs is measured. This test gives information on the ventilation distribution in the lungs.
Study: NCT06443112

Intervention type: PROCEDURE
Intervention: transvaginal cervical cerclage by Mc Donald technique
Description: In the McDonald operation, a suture is is inserted around the exo-cervix as high as possible to approximate to the level of the internal os and thereby prevent second-trimester abortion.

Intervention type: PROCEDURE
Intervention: transvaginal cervical cerclage by Mc Donald technique
Description: In the McDonald operation, a suture is is inserted around the exo-cervix as high as possible to approximate to the level of the internal os and thereby prevent second-trimester abortion.

Intervention type: PROCEDURE
Intervention: transvaginal cervical cerclage by Mc Donald technique
Description: In the McDonald operation, a suture is is inserted around the exo-cervix as high as possible to approximate to the level of the internal os and thereby prevent second-trimester abortion.
Study: NCT04073212

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dry Needling
Description: Dry needling directly to the long head of the biceps tendon. The DN will be performed with disposable stainless-steel needles (.3 X 40mm; Seirin; Weymouth, MA) inserted into the skin over the most painful and/or thickened areas of the tendon, confirmed with palpation. Prior to insertion of the needle the overlying skin will be cleaned with alcohol. The needle will be inserted into the tendon. The technique will be a fast-in and fast-out technique described by Chiavaras et al.26 for 20-30 repetitions per session in up to 3 areas. An eccentric-concentric exercise program of the biceps muscle/tendon will follow each DN session and will be performed daily for the course of treatment and will be performed as described by McDevitt et al.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Heavy Slow Load Exercise
Description: Eccentric exercise protocols have been found to be an effective treatment for tendinopathies of the upper and lower extremities and recent evidence supports heavy slow resistance training (including the addition of a concentric phase) as having better outcomes over eccentric exercise alone. Patients will use 1-5 pound weights to perform slow and controlled concentric and eccentric exercise to biceps muscle.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rotator cuff and scapular stabilization exercise program
Description: Both groups will be treated with a stretching and strengthening program. The rotator cuff and scapular stabilization strengthening and flexibility program used in this study has 3 phases and patients progress in phases based on their ability to perform a number of exercises using theraband or body weight resistance.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Rotator cuff and scapular stabilization exercise program
Description: Both groups will be treated with a stretching and strengthening program. The rotator cuff and scapular stabilization strengthening and flexibility program used in this study has 3 phases and patients progress in phases based on their ability to perform a number of exercises using theraband or body weight resistance.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Soft tissue mobilization
Description: Both groups will receive soft tissue mobilization to the anterior shoulder.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Soft tissue mobilization
Description: Both groups will receive soft tissue mobilization to the anterior shoulder.
Study: NCT05573685

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: DiNaMo Study App
Description: Study App to be used in patients with 1 of the 4 indications of rheumatoid arthritis, fibromyalgia Irritable Bowel Syndrome, Diabetic Neuropathy
Study: NCT06425562

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Impulse oscillometry
Description: Non-invasive physiological measurement / lung function test. This technique superimposes sound waves on tidal breathing. The patient can breathe normally trough the device, no forced respiratory maneuvers are required. It gives information on the reactance and resistance of the lung.
Study: NCT06608966

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Epilepsy Journey web-based modules
Description: Participants assigned to Epilepsy Journey modules will independently review web-based EJ modules focused on executive functioning skills. The modules cover 10 topic areas: Positive Thoughts, Problem-Solving, Initiation, Working Memory, Monitoring, Inhibition, Emotional Control, Organization and Planning, Sleep/Stress, and a Wrap-Up. Participants will complete 10 modules (\~15-30 minutes each session) within a 14-week time frame. The goal is to complete one module per week.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Telehealth with a therapist
Description: Therapist will cover 10 areas of executive functioning during telehealth sessions, including Positive Thoughts, Problem-Solving, Initiation, Working Memory, Monitoring, Inhibition, Emotional Control, Organization and Planning, Sleep/Stress, and a Wrap-Up. Telehealth sessions with a therapist will occur via HIPAA-compliant videoconference (e.g. Microsoft Teams) each week ideally over the course of 14 weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Telehealth with a therapist
Description: Therapist will cover 10 areas of executive functioning during telehealth sessions, including Positive Thoughts, Problem-Solving, Initiation, Working Memory, Monitoring, Inhibition, Emotional Control, Organization and Planning, Sleep/Stress, and a Wrap-Up. Telehealth sessions with a therapist will occur via HIPAA-compliant videoconference (e.g. Microsoft Teams) each week ideally over the course of 14 weeks.
Study: NCT06173349

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PLZ4-coated paclitaxel loaded micelles (PPM)
Description: Given PLZ4-coated paclitaxel loaded micelles intravesically
Study: NCT05298904

Intervention type: DIAGNOSTIC_TEST
Intervention: Genetic Health Screen Panel
Description: This panel covers cardiomyopathy genes, and cancer genes. The results of this panel are reported as Positive (pathogenic or likely pathogenic mutation identified in one or more genes) or Negative (no pathogenic/likely pathogenic mutations identified).
Study: NCT06679270

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metreleptin
Description: Metreleptin is a recombinant human leptin analog that is indicated as an adjunct to diet as replacement therapy to treat the complications of leptin deficiency
Study: NCT05627856

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GNC-038
Description: Administration by intravenous infusion
Study: NCT06148935

Intervention type: DRUG
Intervention: Vericiguat (Verquvo, BAY1021189)
Description: Following the manner of observational study, no intervention will be provided in the study. Participants follow locally approved label, without interference by the study initiator or study protocol
Study: NCT06383845

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lido-IV
Description: Intravenous Lidocaine dose loading than a continuous infusion
Study: NCT04428307

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditional artemisinin combination therapy subsidy
Description: An additional discount on WHO-approved quality assured ACTs will be offered to individuals with a positive RDT.
Study: NCT05632900

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Endoscopic ultrasound guided drainage of walled off pancreatic necrosis
Description: It is Therapeutic procedure to treat walled off pancreatic necrosis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endoscopic ultrasound guided drainage of walled off pancreatic necrosis
Description: It is Therapeutic procedure to treat walled off pancreatic necrosis.
Study: NCT04428307

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conditional artemisinin combination therapy subsidy
Description: An additional discount on WHO-approved quality assured ACTs will be offered to individuals with a positive RDT.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Testing incentive
Description: A small incentive will be paid to the provider each time they perform a malaria rapid diagnostic test.
Study: NCT05084963

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IRL201104
Description: lyophilised powder for reconstitution for IV dosing

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IRL201104
Description: lyophilised powder for reconstitution for IV dosing

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching placebo for IRL201104
Study: NCT05521360

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Autonomic Modulation Training
Description: AMT is a six week online behavioral intervention comprised of two components. The first component is an adapted (to online format) version of an established and publicly available HRVBF protocol (Lehrer et al, 2013, Biofeedback).The second is the integration of meta-cognitive coping skills and autonomic modulation breathing techniques into the HRVBF protocol (Arpaia \& Andersen, 2019 Frontiers in Psychiatry; Andersen, Arpaia \& Gustafsberg, 2021 Int J Emerg Ment Health and Human Resilience).
Study: NCT05835804

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GCP intratumoral catheter
Description: After local anaesthesia, intratumoral catheter will be place (one or several depending tumour criteria).The catheter placement could be guided by radiological imaging. Gemcitabine (200mg/l), carboplatin (100mg/l) and paclitaxel (20mg/l) will be each diluted in each in 160ml of NaCl0.9%. GCP will be administered successively for 8hours, at 20ml/h with a total duration of 24hours. The ITC will be done every 28 days for 6 times maximum in case of good response and tolerance. Nivolumab 240 mg IV will be started 1 to 7 days before the first intratumoral infusion and every 15 days, until progression or 2 until years in case of partial response, complete response or stabilization. Evaluation of tumour size will be done by CT-scan, or MRI 2every 2 months and PET-FDG every 3 months.
Study: NCT05877274

Intervention type: OTHER
Intervention: Sodium channel mutation
Description: Mutation of the genes SCN9A and SCN10A, which encode for Sodium channel 1.7 and 1.8.
Study: NCT04532879

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: HygiPrep (HyGIeaCare System)
Description: Controlled gravity-based high-volume colon irrigation
Study: NCT05439707

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: transaricular vagus nerve stimulation
Description: The transaricular vagus nerve stimulator was placed in the left ear trunk, which is dominated only by the auricular branch of the vagus nerve. Continuous stimulation was performed at a frequency of 25Hz with pulse width of 300 μs. The stimulation was adjusted to be higher than the perception threshold and lower than the pain threshold. Each stimulation lasted for 30 minutes, three times per day (morning, noon, evening), from 1 day before surgery to 7 days after surgery, and the treatment lasted for 9 consecutive days.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: fake transaricular vagus nerve stimulation
Description: The transaricular vagus nerve stimulator was placed in the same position as the experimental group, covered with an insulating film and placed at the site of the stimulation, so that the patient could not actually receive the electrical stimulation. Continuous stimulation was performed at a frequency of 25Hz and pulse width of 300 μs, and the stimulation was adjusted to be higher than the perception threshold and lower than the pain threshold. Each stimulation lasted for 30 minutes, three times per day (morning, noon, evening), from 1 day before surgery to 7 days after surgery, for 9 consecutive days.
Study: NCT06268145

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ECC5004
Description: A single dose tablet of 50 mg of the current tablet formulation (F1) or new tablet formulation (F2) administered orally.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ECC5004
Description: A single dose tablet of 50 mg of the current tablet formulation (F1) or new tablet formulation (F2) administered orally.
Study: NCT05171829

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Track U
Description: Track U diary
Study: NCT05578027

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Mild moxibustion with moxa stick
Description: To conduct this intervention, we used moxa sticks which were 1.5 cm in diameter, 13 cm long, and weighed 12 gram to perform mild moxibustion manipulation at the control acupoint (the left side Pishu acupoint) or Mingmen acupoint in 2 trial phases. The main ingredient of the moxa was dried mugwort leaf, produced in Vietnam. All moxa materials were obtained from the Sai Gon TCS Co., Ho Chi Minh City, Vietnam.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Mild moxibustion with moxa stick
Description: To conduct this intervention, we used moxa sticks which were 1.5 cm in diameter, 13 cm long, and weighed 12 gram to perform mild moxibustion manipulation at the control acupoint (the left side Pishu acupoint) or Mingmen acupoint in 2 trial phases. The main ingredient of the moxa was dried mugwort leaf, produced in Vietnam. All moxa materials were obtained from the Sai Gon TCS Co., Ho Chi Minh City, Vietnam.
Study: NCT06179368

Intervention type: DIAGNOSTIC_TEST
Intervention: hypothroidism
Description: throid fuction will be evaluated on admission of hepatic failure patients, and the hypothyroid patients will be enroled in this group.

Intervention type: DIAGNOSTIC_TEST
Intervention: euothyroid
Description: throid fuction will be evaluated on admission of hepatic failure patients, and the euothyroid patients will be enroled in this group.
Study: NCT05018936

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Hetrombopag
Description: Hetrombopag starting at 5mg/day and increased by 2.5mg/day every 2 weeks if the platelet count remains less than 20×10e9/L and reduced if the platelet count reaches over than 150×10e9/L.
Study: NCT06119022

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Invasive coronary angiography
Description: Patients with positive myocardial ischemia either in CT-MPI guided arm or SPECT-MPI guided arm will scheduled to undergo invasive coronary angiography.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Invasive coronary angiography
Description: Patients with positive myocardial ischemia either in CT-MPI guided arm or SPECT-MPI guided arm will scheduled to undergo invasive coronary angiography.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: routine medical treatment
Description: Patients with negative myocardial ischemia either in CT-MPI guided arm or SPECT-MPI guided arm will scheduled to have routine medical therapy instead of invasive coronary angiography.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: routine medical treatment
Description: Patients with negative myocardial ischemia either in CT-MPI guided arm or SPECT-MPI guided arm will scheduled to have routine medical therapy instead of invasive coronary angiography.