TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06752499

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Individualized online rTMS
Description: 5 Hz rTMS is applied to the MRI-localized hotspot on the affected hemisphere when the patients are performing motor tasks.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Non-individualized online rTMS
Description: 5 Hz rTMS is applied to the conventional hotspot on the affected hemisphere when the patients are performing motor tasks.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham stimulation
Description: Sham rTMS is applied to the MRI-localized hotspot on the affected hemisphere when the patients are performing motor tasks.
Study: NCT06754059

Intervention type: DRUG
Intervention: Pyrotinib
Description: In this study, after at least 4 cycles of taxoid chemotherapy combined with trastuzumab ± pertuzumab, the evaluation result reached SD, CR or PR, and capecitabine combined with pyrotinib + trastuzumab was given successively in the later period (capecitabine was used for 4-6 cycles
Study: NCT06751771

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: comprehensive correcting exercise program
Description: Group A will be treated with comprehensive correcting exercise program (three times a week for 6 weeks) into 3 phases with different intensity and frequency

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: McKenzie's method of exercises
Description: Group B will receive the McKenzie's method of exercises that include Deep neck flexor (chin tucks), Shoulders shrug McKenzie exercise for neck, Repeated shoulder flexion/Extension, Neck flexion McKenzie exercises
Study: NCT02891967

Intervention type: OTHER
Group type: OTHER
Intervention: bulk fill composite
Description: cavities will be incrementally layered with resin composite and each increment will be cured as directed by the manufacturer with the light curing unit (XL 3000; 3M/eSPe), with an energy higher than 450 mW/cm² (±50 mw/cm²)

Intervention type: OTHER
Group type: OTHER
Intervention: bulk fill composite
Description: cavities will be incrementally layered with resin composite and each increment will be cured as directed by the manufacturer with the light curing unit (XL 3000; 3M/eSPe), with an energy higher than 450 mW/cm² (±50 mw/cm²)

Intervention type: OTHER
Group type: OTHER
Intervention: Nano resin composite (K Z350 xt)
Description: cavities will be restored by bulk fill composite (3M ESPE) as one increment then will be cured as directed by the manufacturer with the light curing unit.

Intervention type: OTHER
Group type: OTHER
Intervention: Nano resin composite (K Z350 xt)
Description: cavities will be restored by bulk fill composite (3M ESPE) as one increment then will be cured as directed by the manufacturer with the light curing unit.
Study: NCT06753123

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: A workplace-based depression intervention for low-wage hospital workers
Description: This intervention is a remotely delivered workplace-based depression intervention that is tailored to the specific social and behavioral needs of low-wage hospital service workers. The intervention involves assessment of depression-related work impairment, work-focused cognitive behavioral therapy, work coaching, social needs screening and referral, and text message support for mood and physical activity.
Study: NCT06751914

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Conventional second-line therapy
Description: Conventional second-line therapy includes chemotherapy, targeted cancer drugs, and/or PD-1 inhibitors.The chemotherapy drugs, dosage and treatment cycle are determined by the subject's attending physician based on the subject's specific conditions. The medication, dosage and treatment cycle of targeted cancer drugs will be determined by the subject's attending physician based on the subject's specific circumstances. The PD-1 inhibitor treatment cycle is 3 weeks, and the drug is administered by intravenous infusion on the first day (D1) of each treatment cycle. The dosage is based on the instructions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Neoantigen-based peptide vaccine
Description: The treatment with personalized tumor neoantigen-based peptide vaccine is divided into two periods: the primary phase and the boost phase. The primary phase consists of 6 treatments, with the first 3 treatments spaced one week apart and the subsequent 3 treatments spaced two weeks apart. Vaccine will be administrated on the fourth day (D4) of that week. The boost phase consists of 4 treatments, each spaced three weeks apart. Vaccine will be administrated on the fourth day (D4) of that week.
Study: NCT06755190

Intervention type: DIAGNOSTIC_TEST
Intervention: Diagnostic Test: AI-Based Diagnostic and Prognostic Model for Ocular Diseases
Description: This intervention involves an AI system that leverages multimodal data fusion to support the clinical decision-making and evaluation of ophthalmic diseases. It integrates multi-modal data, including fundus photography, optical coherence tomography (OCT), and patient clinical records, to provide real-time, precise, and personalized diagnostic support. Unlike other models, this system utilizes a longitudinal patient dataset to predict disease progression and treatment outcomes.Key distinguishing features include: 1. Multi-Modal Data Integration: Combines imaging, clinical, and genetic data for comprehensive analysis. 2. Predictive Capability: Offers advanced prognostic predictions, enabling personalized treatment plans. 3. Deep Learning Framework: Employs state-of-the-art deep learning algorithms for improved diagnostic accuracy and efficiency. 4. Real-World Validation: Validated using a large cohort of diverse patient data, ensuring generalizability and robustness.
Study: NCT06755099

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Botox
Description: The patient will be placed in gynecological position. Subsequently, the patient will be anesthetized with propofol bolus, a total of 270 mg IV sterilization of valval area with antiseptic solution then digital examination to assess the spasm of intriotus and vaginal walls under lowest possible doses then increasing the doses to allow for intra vaginal injection of Botox under full sedation. Pacik technique will be adopted for Botox Injection in the vagina .~. One vial of frozen Botox 100 U will be diluted with 2 mL saline, without foaming or shaking the vial, giving a concentration of 2.5 U/0.05 mL . Using a small sized speculum and after bending the needle to 30° to facilitate injection into sub mucosal area,1 mL (50 U) of Botox will be injected into the right bulbocavernosus then into the left side .

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Radiofrequency
Description: Patients will be placed in prone position. After proper disinfection, the ischial spine (IS) and insertion point of the sacrospinous ligament will be identified using fluoroscopy medial to IS. 5 ml Lidocaine 2 % will be used to apply local anesthesia to the skin at the expected entry point for the radiofrequency cannula. Then a 20 G, 10 cm long and 1 cm active tip radiofrequency cannula will be introduced gradually utilizing 2 Hz motor stimulation until pudendal nerve is identified visually by the occurrence of contraction of the external anal sphincter muscle.~Subsequently, pulsed radiofrequency lesioning at temperature limit of 42 C will be applied bilaterally to the pudendal nerves for 240 s (2 cycles of 120 s) after applying local anesthesia using 2 cm 2% lidocaine in its vicinity.
Study: NCT06446154

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fruquintinib
Description: Fruquintinib was given orally for 5mg/ days. After 3 weeks, the drug was stopped for 1 week.
Study: NCT05645328

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Iowa Cancer Affiliate Network (ICAN)
Description: Each hospital in the intervention has undergone interviews in which the investigators elicited program goals, challenges, and readiness for change. Prior to the intervention, the cancer centers will be provided a document specifying current status for meeting Commission on Cancer (CoC) accreditation standards, gaps identified, suggestions and resources for the next steps to meet goals, and progress toward fulfilling CoC accreditation standards. The hospitals will be offered support, expertise, and resources to facilitate them in achieving the CoC standards. Support will be offered in the form of education/training regarding the standards and provision of cancer services, regular in-person/zoom check-ins with hospital stakeholders to evaluate progress, and provision of documentation/educational resources regarding standard requirements. The intervention actions will be tailored to the needs of each hospital based on standards they currently do not meet and choose to work toward.
Study: NCT06189976

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Rapid atrial pacing
Description: Rapid atrial pacing after TAVI
Study: NCT05231798

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: [18F]-FEOBV Radiotracer
Description: Participants will be administered an \[18F\]-fluoroethoxybenzovesamicol (FEOBV) radiotracer for diagnostic imaging purposes (PET scan).
Study: NCT06521294

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mulligan SNAG mobilization tecnique
Description: Mulligan SNAG mobilization tecnique
Study: NCT04791189

Intervention type: OTHER
Intervention: questionnaire
Description: questionnaire to survey the needs of adolescents with juvenile idiopathic arthritis and the views of their parents in the area of sexual health.

Intervention type: OTHER
Intervention: questionnaire
Description: questionnaire to survey the needs of adolescents with juvenile idiopathic arthritis and the views of their parents in the area of sexual health.
Study: NCT05099185

Intervention type: BIOLOGICAL
Intervention: Water-soluble vitamins and trace elements measures
Description: We would like to measure water-soluble vitamins (B1, B6, B9, B12, C) and trace elements (zinc, selenium) in blood and dialysate for the patients treated by online post-dilution hemodiafiltration patients. There measures on blood are done systematically during the half-yearly report of our patients in our hemodialysis center. Only results are collect for the study.
Study: NCT06104254

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: education
Description: we will give an education to experimental group about pain and pain management.
Study: NCT05458999

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual reality headset during percutaneous coronary intervention
Description: Virtual reality glasses during percutaneous coronary intervention
Study: NCT06379763

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional physiotherapy exercise
Description: conventional physiotherapy exercise such as ROM, stretching exercises for superficial neck muscles

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional physiotherapy exercise
Description: conventional physiotherapy exercise such as ROM, stretching exercises for superficial neck muscles
Study: NCT05811455

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aerobic exercises
Description: To compare the effects of aerobic exercise and progressive muscle relaxation exercises on pain and quality of life in premenstrual syndrome

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Progressive muscle relaxation
Description: progressive muscle relaxation exercises.
Study: NCT06521294

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Conventional Physiotherapy
Description: Conventional Physiotherapy

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Physiotherapy
Description: Conventional Physiotherapy
Study: NCT05728619

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HTMC0435
Description: Oral administration.
Study: NCT05162703

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: AsthmaTuner
Description: Exercise challenge test using AsthmaTuner mobile phone app and spirometer.
Study: NCT05728619

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HTMC0435
Description: Oral administration.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Temozolomide
Description: Oral administration.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Temozolomide
Description: Oral administration.
Study: NCT05650684

Intervention type: OTHER
Intervention: data collection
Description: continuation of exclusive breastfeeding until the post-natal visit (6 to 8 weeks after birth)
Study: NCT04881864

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tele-Enhance Fitness
Description: Livestream, instructor-led tele-exercise classes, involving balance, endurance, and strength training
Study: NCT06237738

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stress Ball Use
Description: The intervention in this study involves the use of stress balls provided to participants in the intervention group. These are specially designed medium-firm silicone balls intended for squeezing with the hand opposite the one receiving cannulation during hemodialysis sessions. The primary objective of this intervention is to offer a simple, non-pharmacological method to potentially alleviate the pain associated with the cannulation process. Participants are instructed to use the stress ball for a period of three minutes before the start of cannulation. This activity is hypothesized to focus the participant's attention and possibly reduce the perception of pain, contributing to a more comfortable and less distressing cannulation experience.
Study: NCT05852275

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Olive-oil
Description: Participants will add to their usual diet a daily intake of 30 mL of an olive oil rich in polyphenols for 3-months (100 days)
Study: NCT06235021

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Saffron
Description: Saffron powder (purchased from Moayeri Copmany2 in Oman, prepared from the stigma of Crocus sativus L.).~Total of 10 mg of saffron powder will be added to 100 ml of distilled water. Then, it will be incubated on a shaker for 24 h. The material will be passed through several layers of muslin cloth. The extracts will then be poured into a round bottom balloon and placed in the freezer at a temperature of -80°C. After freezing, the extracts were placed in a freeze-dryer.~In vacuum, the solvent will be removed and saffron powder will be obtained. After preparing the initial concentration, serial dilution with ratios of one-half and one-third will be performed in sterile vials and one-half of the final concentration will be discarded.~After the preparation of extract, the 0.2% saffron mouthwash will be prepared by mixing the following ingredients: 1. propylene glycol (5 g) 2. saffron extract (0.2 g) 3. polysorbate 80 (1.8 g) 4. sodium benzoate (0.2 g) 5. water (91 g).

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: chlorhexidine mouthwash
Description: commercial product of 0.2% chlorhexidine mouthwash.
Study: NCT06181084

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3410738
Description: Administered orally.
Study: NCT06175793

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ASPIRE Intervention
Description: In addition to usual care and a free blood pressure cuff, participants in the intervention arm will receive the ASPIRE components: (1) ASPIRE Tool Kit, (2) ASPIRE Coach, (3) SMBP EHR Documentation, and (4) screening and addressing SDOHs.
Study: NCT05589051

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Drink
Description: Consume one tablet fully dissolved in 8 ounces. Take 2 tablets per day for adults (morning and evening) for 4 weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Drink
Description: Consume one tablet fully dissolved in 8 ounces. Take 2 tablets per day for adults (morning and evening) for 4 weeks
Study: NCT04690855

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Talazoparib
Description: Talazoparib 1 mg Orally Day 1 to Day 28

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atezolizumab
Description: Atezolizumab 840 mg IV over 60 minutes Day 15 of Cycle 1 then Day 1 and Day 15 of subsequent Cycles

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Radiation
Description: Radiation 8 Gy will be given in 3 fractions QOD beginning Day 12, 13 or 14 of Cycle 1 but 24-72 hours prior to 1st dose of Atezolizumab
Study: NCT04774718

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Alectinib
Description: Participants will receive twice-daily alectinib capsules on Days 1-28 of each 28-day cycle
Study: NCT06181084

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3410738
Description: Administered orally.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3410738
Description: Administered orally.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LY3410738
Description: Administered orally.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esomeprazole
Description: Administered orally.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esomeprazole
Description: Administered orally.
Study: NCT05500469

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Paul glaucoma drainage device (GDD)
Description: Implantation of the GDD

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Paul glaucoma drainage device (GDD)
Description: Implantation of the GDD
Study: NCT06265597

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Healthy Nutrition and Yoga Program
Description: * Healthy Nutrition Program~  * At the beginning of the Healthy Nutrition and Yoga Program by the researcher give education to families and children in 3 sessions (Importance of Nutrition in School Age, Obesity in School Age, Nutrition Recommendations for Obese Children).~ * Providing individual counseling to children every 2 weeks from the start of the Healthy Nutrition Program, in cooperation with a nutritionist, in line with the basic healthy eating behavior goals.~ * After the 2nd session of the healthy nutrition education and from the beginning of the Yoga Program, in the 2nd, 4th, 6th, 8th and 10th weeks, children are asked to keep a food diary for 2 weekdays and 1 weekend (Thursday-Friday-Saturday) and planning is made according to reaching basic healthy nutrition behavior goals.~* Yoga Program \*Children's yoga is applied to each group twice a week for 12 weeks.
Study: NCT06145542

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: AR group: aerobic training before resistance training
Description: Exercise are performed 3 times/wk for 8 wks.~Aerobic training sessions are performed using cycle ergometers. Riding speed is 55-60 rotations/min, at an intensity between 50%-75% of heart rate reserve (HRR). Real-time heart rate monitors are worn by each participant during the session. Aerobic training session lasts for 30 minutes, with an additional 5-minute warm-up and 5-min relaxation training before and after the session, respectively.~Participants perform resistance exercise on a set of strength training equipment. Load of resistance exercise is between 60-80% of repetition maximum (RM) in each set of exercise. Six different groups of resistance exercise (involving contractions and relaxations of biceps, triceps, pectoralis major, latissimus dorsi, quadriceps, and hamstrings) are conducted, with 6 sets of 10 repeated tasks in each group. Participants are instructed to finish each set of exercise task within 60 seconds. Between each two sets, there are 60 s of rest time.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: RA group: resistance exercise before aerobic exercise
Description: Exercise are performed 3 times/wk for 8 wks.~Following a 5-min warm-up exercise, the participants perform resistance training on a set of equipment. Load of resistance exercise is set between 60-80% of repetition maximum in each set of exercise. Six different groups of resistance exercise (involving contractions and relaxations of biceps, triceps, pectoralis major, latissimus dorsi, quadriceps, and hamstrings) are conducted, with 6 sets of 10 repeated tasks in each group. Participants are instructed to finish each set of exercise task within 60 s. Between each two sets, there are 60 seconds of rest time.~Aerobic training sessions are performed using cycle ergometers. Riding speed is 55-60 rotations/min, at an intensity between 50%-75% of heart rate reserve. Real-time heart rate monitors are worn during the entire session. Each aerobic training session lasts for 30 minutes, with an 5-minute relaxation training after the session.
Study: NCT04757623

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Purse string closure of Ileostomy
Description: conventional proceedure
Study: NCT06534632

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mother's colostrum
Description: Oropharyngeal administration of mother's colostrum

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Oropharyngeal administration of sterile water
Study: NCT05563636

Intervention type: DEVICE
Group type: OTHER
Intervention: standard pulsed radio frequency (PRF)
Description: patients will be given standard pulsed radiofrequency (PRF) treatment: temperature 42 ℃, frequency 2 Hz, pulse width 20 ms, voltage 37-41 V, time 120 s.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: high-voltage long-term pulsed radio frequency (PRF)
Description: patients will be given standard pulsed radiofrequency (PRF) treatment: temperature 42 ℃, frequency 2 Hz, pulse width 20 ms, voltage 50-90 V, At the beginning, the patient will feel a severe burning sensation in the original pain area, and slowly after the patient tolerates it. Increase the voltage and gradually increase to the maximum voltage that the patient can tolerate (up to 70-90 V) until the end of 900 s.
Study: NCT06105073

Intervention type: PROCEDURE
Intervention: Pulmonary Rehabilitation Program
Description: Consecutive patients who attend with a confirmed diagnosis of Systemic Sclerosis associated Interstitial Lung disease, at the Speciality Hospital from the Medical Center La Raza IMSS. The anxiety and depression questionnaire will be applied to them. Goldberg, as well as the SF-36 questionnaire to evaluate quality of life and the SySQ questionnaire to evaluate functionality, to include these data in the analysis, these questionnaires are validated in our population and have been widely used. All participants (T0) will undergo Forced Spirometry, Carbon Monoxide Diffusion Capacity and Cardiopulmonary Exercise Test. Then they will enter a supervised pulmonary rehabilitation program that consists of 36 sessions, which is equivalent to 12 weeks. At the end of this period (T1), again the respiratory function tests (spirometry, DLCO and Cardiopulmonary Exercise Test) as well as the Goldberg, SF-36 and SySq questionnaires.
Study: NCT06398613

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: extended pelvic lymph node dissection (ePLND)
Description: Prostate-Specific Membrane Antigen Emission Tomography/Computed Tomography (PSMA PET/CT) will done preoperatively in both arms of the study. In arm A all patients will undergo ePLND, in arm B only patients with positive PSMA PET/CT will undergo ePLND
Study: NCT04969900

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo oil
Description: The placebo group will receive placebo oil.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Lavender oil.
Description: Investigational Product. This group will receive Lavender oil.