Study: NCT05367596

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Continuous Energy Restriction (CER)
Description: Energy intake will be prescribed at approximately 1,200-1,500 kcal/day with high protein. The diet will consist of low-calorie shakes provided by the study, as well as commercially available portion-controlled entrées, fruits/vegetables, and low energy-density foods available in grocery stores.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Alternate Day Modified Fasting (ADMF)
Description: Enhanced Care participants will have an alternate between three days of very-low energy intake (VLED; approximately 600-800 kcal/d) and four days of healthy eating (HE) each week. On HE days, participants will consume foods ad libitum for satiety.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Group Health Education Sessions
Description: Using video conferencing, all participants will attend weekly approximately 45-60 minutes group health education sessions led by a registered dietitian. The session will deliver a comprehensive nutritional and lifestyle change program to promote lifestyle changes and improve compliance.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Group Health Education Sessions
Description: Using video conferencing, all participants will attend weekly approximately 45-60 minutes group health education sessions led by a registered dietitian. The session will deliver a comprehensive nutritional and lifestyle change program to promote lifestyle changes and improve compliance.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Late Evening Snack
Description: The participants will have a late evening snack with a protein supplement.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Late Evening Snack
Description: The participants will have a late evening snack with a protein supplement.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Physical activity
Description: All participants will be prescribed moderate-intensity aerobic activities that do not require access to specialized exercise facilities.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Physical activity
Description: All participants will be prescribed moderate-intensity aerobic activities that do not require access to specialized exercise facilities.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self-monitoring
Description: Weekly data related to adherence, food intake, physical activity, weight measurement, and nonserious adverse events will be self-reported via a REDCap survey. Participants will also be provided with a wireless activity tracker to measure total physical activity and intensity of activity objectively. These data will be used to counsel participants in addition to providing valuable feasibility data.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Self-monitoring
Description: Weekly data related to adherence, food intake, physical activity, weight measurement, and nonserious adverse events will be self-reported via a REDCap survey. Participants will also be provided with a wireless activity tracker to measure total physical activity and intensity of activity objectively. These data will be used to counsel participants in addition to providing valuable feasibility data.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Remotely Supervised Exercise Sessions
Description: Sessions of 45 minutes duration will be delivered via video conferencing 2-3 times per week.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Remotely Supervised Exercise Sessions
Description: Sessions of 45 minutes duration will be delivered via video conferencing 2-3 times per week.