TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06268808

Intervention type: DEVICE
Group type: OTHER
Intervention: FreeStyle Libre 2 Flash Glucose Monitoring System
Description: Glucose sensors to be worn continuously for 3 months with data used to monitor and manage diabetes treatment and to inform lifestyle choices (diet and exercise)
Study: NCT05410522

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: EMS Program
Description: Lower limb electrostimulation therapy is scheduled for lung transplant patients. The therapy consists in the application of 2 daily 30-minute sessions that begin in the first 48 hours post-transplantation and are maintained daily until discharge from the hospital.
Study: NCT06290115

Intervention type: OTHER
Intervention: Questionnaires set 1
Description: Participants of case group will be asked to respond to the demographic information，the Family Emotional Expressivity Questionnaire（FEEQ）、the Parent-Adolescent Communication Scale（PACS）、the Childhood Trauma Questionnaire（CTQ）、the Parental Bongding Instrument（PBI）、the Adolescent parent-child relationship intimacy questionnaire and the Ottawa Self-injury Inventory（OSI）.

Intervention type: OTHER
Intervention: Questionnaires set 2
Description: Participants of control group 1 will be asked to respond to the demographic information，the Family Emotional Expressivity Questionnaire（FEEQ）、the Parent-Adolescent Communication Scale（PACS）、the Childhood Trauma Questionnaire（CTQ）、the Parental Bongding Instrument（PBI） and the Adolescent parent-child relationship intimacy questionnaire.

Intervention type: OTHER
Intervention: Questionnaires set 3
Description: Participants of control group 2 will be asked to respond to the demographic information，the Family Emotional Expressivity Questionnaire（FEEQ）、the Parent-Adolescent Communication Scale（PACS）、the Childhood Trauma Questionnaire（CTQ）、the Parental Bongding Instrument（PBI） and the Adolescent parent-child relationship intimacy questionnaire.
Study: NCT05000021

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy for Diabetes Distress (CBT-DD) with Continuous Glucose Monitoring
Description: CBT-DD consists of approximately 10 individual sessions of CBT delivered virtually by trained protocol therapists, conducted over the course of approximately 12 weeks. The CBT-DD consists of 5 core modules targeting negative emotionality and aversive reactions to emotional experiences. These modules are preceded by an introductory session that reviews the patient's presenting symptoms and provides a therapeutic rationale, as well as a module on motivational enhancement. The final module consists of relapse prevention. CBT-DD sessions will integrate a review of Continuous Glucose Monitoring (CGM) data and feedback will be provided by the therapist.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous Glucose Monitoring (CGM)
Description: Use of commercially available, FDA-approved continuous glucose monitoring (CGM) for 6 months post-randomization. Usual diabetes care will continue and participants can initiate a CGM review from their healthcare providers, as desired. In addition, a nurse practitioner with expertise in CGM will train each participant via video recordings in the proper placement of the device, and technical issues, and provide basic teaching at the beginning of the trial on interpretation of CGM data and self-titration of insulin/self-management. Written materials and online resources for recognizing and managing diabetes distress, along with self-management information and treatment options to discuss with providers will also be provided.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Continuous Glucose Monitoring (CGM)
Description: Use of commercially available, FDA-approved continuous glucose monitoring (CGM) for 6 months post-randomization. Usual diabetes care will continue and participants can initiate a CGM review from their healthcare providers, as desired. In addition, a nurse practitioner with expertise in CGM will train each participant via video recordings in the proper placement of the device, and technical issues, and provide basic teaching at the beginning of the trial on interpretation of CGM data and self-titration of insulin/self-management. Written materials and online resources for recognizing and managing diabetes distress, along with self-management information and treatment options to discuss with providers will also be provided.
Study: NCT06403787

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aerobic exercise + Ginkgo Biloba Extract
Description: 12 weeks of intervention for the participants, divided into 3 stages implementing an exercise adaptation period. The adaptation period will span the first 4 weeks of the intervention, during which participants will be brought to an intensity between 50% and 60% of their maximum heart rate (HRmax). From week 5 to 8, the HRmax range will be increased from 60% to 70%, and during the last 4 weeks, it will be maintained at 70% of HRmax combined with 240 mg of LIFE EXTENSION® brand ginkgo biloba extract in 120 mg tablets

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Aerobic exercise + Calcined magnesia (placebo)
Description: 12 weeks of intervention for the participants, divided into 3 stages implementing an exercise adaptation period. The adaptation period will span the first 4 weeks of the intervention, during which participants will be brought to an intensity between 50% and 60% of their maximum heart rate (HRmax). From week 5 to 8, the HRmax range will be increased from 60% to 70%, and during the last 4 weeks, it will be maintained at 70% of HRmax combined with calcined magnesia (homogenized to the same weight of ginkgo biloba)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aerobic exercise + Atorvastatin
Description: 12 weeks of intervention for the participants, divided into 3 stages implementing an exercise adaptation period. The adaptation period will span the first 4 weeks of the intervention, during which participants will be brought to an intensity between 50% and 60% of their maximum heart rate (HRmax). From week 5 to 8, the HRmax range will be increased from 60% to 70%, and during the last 4 weeks, it will be maintained at 70% of HRmax combined with 20 mg of atorvastatin
Study: NCT06472518

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: pharmaco mechanical thrombolysis
Description: arm with the pharmaco mechanical thrombolysis intervention combined with anticoagulant treatment with direct oral anticoagulants

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: pharmaco mechanical thrombolysis
Description: arm with the pharmaco mechanical thrombolysis intervention combined with anticoagulant treatment with direct oral anticoagulants
Study: NCT05440097

Intervention type: OTHER
Group type: OTHER
Intervention: QIP intervention
Description: The QIP includes pulmonologist-targeted guideline education and guideline implementation.~Guideline education includes the initial comprehensive training and reinforcement learning. The initial comprehensive education will be delivered at each participating hospital by a dedicated national asthma expert team, immediately after last patient enrolled at each site. The PI of respiratory departments from participating hospitals are responsible for arranging the delivery of hospital-level reinforcement learnings and ensuring the quality and success of hospital-level guideline implementation.~The pulmonologists' guideline adherence and performance at participating hospitals will be regularly assessed during the study period.
Study: NCT06178419

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: RIC
Description: RIC is a non-invasive therapy that is performed by automated pneumatic cuffs placed on unilateral arms. The RIC protocol includes five cycles of 5-min inflation to 200mmHg and 5-min deflation.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: sham-RIC
Description: Sham-RIC is a non-invasive therapy that is performed by automated pneumatic cuffs placed on unilateral arms. The sham RIC protocol includes five cycles of 5-min inflation to 60mmHg and 5-min deflation.
Study: NCT05624606

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Quadrivalent Influenza mRNA Vaccine MRT5410
Description: Pharmaceutical form: Liquid frozen solution for injection in a vial Route of administration: Intramuscular

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Quadrivalent Influenza mRNA Vaccine MRT5410
Description: Pharmaceutical form: Liquid frozen solution for injection in a vial Route of administration: Intramuscular

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Quadrivalent Influenza mRNA Vaccine MRT5410
Description: Pharmaceutical form: Liquid frozen solution for injection in a vial Route of administration: Intramuscular

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Quadrivalent Recombinant Influenza vaccine RIV4
Description: Pharmaceutical form: Liquid suspension for injection in prefilled syringe Route of administration: Intramuscular

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Quadrivalent Inactivated Influenza Standard Dose QIV-SD
Description: Pharmaceutical form: Liquid suspension for injection in prefilled syringe Route of administration: Intramuscular

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Quadrivalent Inactivated Influenza High Dose QIV-HD
Description: Pharmaceutical form: Liquid suspension for injection in prefilled syringe Route of administration: Intramuscular
Study: NCT05834634

Intervention type: DEVICE
Intervention: Ultrasound
Description: The patients and controls will be scanned at the Neurophysiology unit of the Department of Neurology, Neurology, psychiatry and Neurosurgery hospital, Assiut university hospital. The acquisition of ultrasound images was performed using a Philips HD11XE imaging system with an L12-8 linear array probe. Cross-sectional area (CSA) of the right and left Vagus nerves in each subject, perimeter, echogenicity, and fascicular structure will be assessed and measured by tracing the nerve just inside its hyperechoic rim. The nerve will be seen on ultrasound B-mode near the bifurcation of the carotid artery, dorsal to the internal and common carotid arteries, as a structure that is hypoechogenic in the centre and more hyperechogenic on the periphery (24, 25). Both the carotid artery and the internal jugular vein served as anatomical landmarks (25). Two separate CSA measurements, with the probe repositioned for each measurement, will be taken and they will be averaged.

Intervention type: DEVICE
Intervention: Ultrasound
Description: The patients and controls will be scanned at the Neurophysiology unit of the Department of Neurology, Neurology, psychiatry and Neurosurgery hospital, Assiut university hospital. The acquisition of ultrasound images was performed using a Philips HD11XE imaging system with an L12-8 linear array probe. Cross-sectional area (CSA) of the right and left Vagus nerves in each subject, perimeter, echogenicity, and fascicular structure will be assessed and measured by tracing the nerve just inside its hyperechoic rim. The nerve will be seen on ultrasound B-mode near the bifurcation of the carotid artery, dorsal to the internal and common carotid arteries, as a structure that is hypoechogenic in the centre and more hyperechogenic on the periphery (24, 25). Both the carotid artery and the internal jugular vein served as anatomical landmarks (25). Two separate CSA measurements, with the probe repositioned for each measurement, will be taken and they will be averaged.
Study: NCT05150028

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Patient participation
Description: Questionnaire

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinician barrier reports
Description: How many times a 7 question Survey on medication education practices is opened
Study: NCT05195398

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Anodal transcranial Direct Current Stimulation (A-tDCS)
Description: Participants randomized to tDCS will undergo 5 weeks of A-tDCS + CCT.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Sham Intervention
Description: Participants randomized to sham-intervention will undergo 5 weeks of sham + CCT.
Study: NCT04970134

Intervention type: OTHER
Intervention: Immunohistochemistry (IHC)
Description: VENTANA pan-TRK technique (EPR17341) Assay, with Optiview DAB-detection kit and Optiview amplification kit. Using FFPE slices

Intervention type: OTHER
Intervention: Fluorescence In-Situ Hybridization (FISH)
Description: FISH using FFPE slices for genes: Neurotrophic tyrosin kinase 1 (NTRK1), Neurotrophic tyrosin kinase 3 (NTRK3) and rearranged during transfection (RET)

Intervention type: OTHER
Intervention: Oncomine Focus Assay Platform with 52 genes
Description: Oncomine Focus Assay Platform with 52 genes (35 Hotspot genes, 19 Copy number variants and 23 Gene fusions). Using FFPE slices
Study: NCT05124925

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ianalumab
Description: Ianalumab VAY736 150mg/1ml Solution for injection
Study: NCT04759274

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Diuretic Tuner
Description: Mobile device application for diuretic dose titration
Study: NCT06420882

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: The experimental group.
Description: In the experimental group, in addition to home exercises, patella mobilization, muscle strengthening exercises, range of motion exercises and home exercises will be performed 3 days a week for 3 sessions with a therapist.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: The home exercise group
Description: Participants in both groups will be included in a 3-week treatment programme.
Study: NCT06472284

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TetraGraph
Description: etraGraph is a unique, EMG-based portable device for quantitative (objective) monitoring of neuromuscular function. It is a precise and easy to use tool for monitoring depth of block, ensuring adequate recovery of muscle function, and aiding the clinician to reduce the incidence of residual block.
Study: NCT05845385

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: lumbar epidural analgesia with bupivacaine
Description: postoperative analgesic method

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: transversus abdominis plane block with bupivacaine
Description: postoperative analgesic method

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: wound infiltration with bupivacaine
Description: postoperative analgesic method
Study: NCT04096430

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ENGAGE approach (child-oriented goal-setting)
Description: See description of experimental arm.
Study: NCT05355532

Intervention type: GENETIC
Intervention: different variants of SNPs that may be associated with the coronary microvascular obstruction development
Description: Some variants of SNPs determine endothelial function, microcirculation, hemostasis, and inflammation in MI patients. They may be associated with the development of coronary microvascular obstruction during emergency PCI. A link between the different SNPs and the CMVO development will be established. SNP will be determined by real-time polymerase chain reaction with high-resolution melting curve analysis using TaqMan fluorescent probes.

Intervention type: GENETIC
Intervention: different variants of SNPs that may be associated with the coronary microvascular obstruction development
Description: Some variants of SNPs determine endothelial function, microcirculation, hemostasis, and inflammation in MI patients. They may be associated with the development of coronary microvascular obstruction during emergency PCI. A link between the different SNPs and the CMVO development will be established. SNP will be determined by real-time polymerase chain reaction with high-resolution melting curve analysis using TaqMan fluorescent probes.
Study: NCT05626738

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ENDORAIL
Description: In case caecal intubation time is longer than 10 minutes, the balloon catheter is inserted in the tool channel, advanced beyond the colonoscope tip and filled with Ferromagnetic Fluid. By applying the Endorail Handpiece over the patient abdomen, the balloon can be magnetically anchored. The anchored balloon guide allows to straighten the scope and the colon itself. The colonoscope can thus be easily moved back and forward along the anchored guide to facilitate colonoscope positioning and colonoscopy completion. Afterward, Endorail is removed and the straightened colonoscope can be easily pushed forward to achieve colonoscopy completion according to standard endoscopic technique.
Study: NCT05216016

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: RETAIN Program
Description: Facilitates early intervention strategies to support workers in staying-at or returning-to-work (SAW/RTW) after injury or illness and preventing unnecessary disability. This is done by incorporating a Return-to-Work Case Manager as a member of the healthcare clinical team who acts as a liaison for the patient and assists in coordination of referrals between healthcare and Workforce Development services. Return-to-Work Case Managers will interact with treating providers of Minnesota RETAIN intervention group participants to ensure functionally based work restrictions are documented and shared with the patient's employer.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: RETAIN Program
Description: Facilitates early intervention strategies to support workers in staying-at or returning-to-work (SAW/RTW) after injury or illness and preventing unnecessary disability. This is done by incorporating a Return-to-Work Case Manager as a member of the healthcare clinical team who acts as a liaison for the patient and assists in coordination of referrals between healthcare and Workforce Development services. Return-to-Work Case Managers will interact with treating providers of Minnesota RETAIN intervention group participants to ensure functionally based work restrictions are documented and shared with the patient's employer.
Study: NCT05884554

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07817883
Description: Experimental

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07817883
Description: Experimental

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07817883
Description: Experimental

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PF-07817883
Description: Experimental
Study: NCT05425979

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Mepivacaine
Description: Up to two 30 ml vials of mepivacaine 1.5% via ultrasound-guided nerve blockade of the tibial and deep peroneal nerves

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacaine
Description: Up to two 30 ml vials of bupivacaine 0.5% via ultrasound-guided nerve blockade of the tibial and deep peroneal nerves
Study: NCT06367764

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive Processing Therapy
Description: Cognitive Processing Therapy teaches cognitive restructuring skills to help clients change beliefs and process emotions related to a traumatic event or events.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: STAIR Narrative Therapy
Description: STAIR Narrative Therapy teaches coping skills (e.g., for emotional regulation, interpersonal relationships, everyday stress) and includes a narrative trauma-focused component.
Study: NCT06507943

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Promotora Home Visit
Description: For each participating family, Promotora home visits will be scheduled 6-8 weeks apart, with in-person or virtual visits conducted per the family's preference. The visits will begin with a survey which will evaluate concerns related to asthma for the child and the family, including their asthma control (via the ACT), their home environment (via screening for environmental exposures), and quality of life for the child. These surveys will be available in both online or physical forms for potential connectivity concerns, and Promotoras will have IPads for the online forms. The Promotoras, who have received specialized asthma training, will then address concerns raised by families, using the Clinical Pathway which will have resources for asthma-related concerns that are raised.
Study: NCT04909710

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mobile Game System for Potential Treatment of Developmental Delays
Description: Mobile game system meant to generate valuable data for measuring progress and building novel artificial intelligence models while delivering impactful education for and treatment of children with developmental delays such as autism.

Intervention type: OTHER
Group type: OTHER
Intervention: Mobile Game System for Potential Treatment of Developmental Delays
Description: Mobile game system meant to generate valuable data for measuring progress and building novel artificial intelligence models while delivering impactful education for and treatment of children with developmental delays such as autism.
Study: NCT04709068

Intervention type: DEVICE
Intervention: Current Health
Description: wearable device and tablet used to collect health measures at home
Study: NCT05228470

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Elranatamab
Description: BCMA-CD3 bispecific antibody
Study: NCT06472141

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cervical stabilization exercises
Description: Cervical Stabilization Exercises will be performed 3 days a week for 8 weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard treatment (Education + home exercises)
Description: Individuals will be informed about TMJ disorders, parafunctional activities (chewing gum, nail/pen biting, etc.) and recommendations. In addition, Rocabado exercises will be given as a home program.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard treatment (Education + home exercises)
Description: Individuals will be informed about TMJ disorders, parafunctional activities (chewing gum, nail/pen biting, etc.) and recommendations. In addition, Rocabado exercises will be given as a home program.
Study: NCT04776395

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: Given PO

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: Given PO

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Iberdomide Hydrochloride
Description: Given PO

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Iberdomide Hydrochloride
Description: Given PO

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Quality-of-Life Assessment
Description: Ancillary studies

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Quality-of-Life Assessment
Description: Ancillary studies
Study: NCT05989009

Intervention type: OTHER
Intervention: Breastfeeding
Description: Mothers will breastfeed their newborns

Intervention type: OTHER
Intervention: Breastfeeding
Description: Mothers will breastfeed their newborns

Intervention type: OTHER
Intervention: Breastfeeding
Description: Mothers will breastfeed their newborns