TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06265753

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gastrocinemius Function Massage
Description: The purpose of gastrocnemius massage is to alleviate muscle stiffness in the gastrocnemius muscle and enhance mobility in the foot and ankle of the individuals involved. During the GFM application, the patient assumes a prone posture on a suitable treatment bed. The therapist positions themselves behind the patient's side and secures the patient's foot between their hip and ilium.The therapist firmly holds the gastrocnemius muscle using both hands and applies pressure to the ankle, causing it to move in the direction of dorsiflexion. Simultaneously, the therapist applies mobilisation in the cranial direction, following the same path as the gastrocnemius muscle fibres, using both hands. Afterwards, the therapist gently pulls the arm and trunk backwards until the foot and gastrocnemius muscle become relaxed. The application is sustained in a rhythmic manner . We will apply this massage aproximately 10 min to experimental group.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham application
Description: The sham application was conducted when the patient was lying face down, with the hands placed on the gastrocnemius muscle without any movement. We will apply this application aproximately 10 min to experimental group.
Study: NCT06009926

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo Administration
Description: Given PO
Study: NCT04763083

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NVG-111
Description: Open label, continuous iv infusion, escalating doses of NVG-111 for minimum 3 cycles
Study: NCT06009926

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaire Administration
Description: Ancillary studies
Study: NCT06184581

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lithium Carbonate
Description: The trial is designed as a single-blinded two-armed, parallel randomized trial with randomization 1:1 to lamotrigine versus lithium.
Study: NCT05073380

Intervention type: BEHAVIORAL
Group type: SHAM_COMPARATOR
Intervention: Intervention Group - PRO-ECO Intervention
Description: The PRO-ECO intervention will be tailored to individual sites. Through collection of focus group and baseline data, the intervention will be further refined to provide site-specific adjustments, such as specific materials in the built environment design modification or targeted training. Identified features of effective interventions outlined in the literature have informed the development of the intervention foundation and potential tailoring.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Wait List Group - Normal Daily Practice
Description: ELCCs that are randomly assigned to the waitlist group will participate in their normal daily practice, including standard curriculum and outdoor play time. Once post-data collection is complete, wait list sites will be given the PRO-ECO intervention.
Study: NCT05941390

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: VR without positive psychology
Description: Using VR goggles showing relaxing short videos without sound
Study: NCT06009926

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Training
Description: Undergo flashover training
Study: NCT06184581

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Lamotrigine
Description: The trial is designed as a single-blinded two-armed, parallel randomized trial with randomization 1:1 to lamotrigine versus lithium.
Study: NCT05941390

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: VR with positive psychology
Description: Using VR goggles showing relaxing short videos with positive psychological messages
Study: NCT04854460

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Revemact
Description: 1 tablet contains 6 mg Ivermecin
Study: NCT04854460

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Stromectol (first dose)
Description: 2 tablet contain 6 mg Ivermecin

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Stromectol (second dose)
Description: 2 tablet contain 6 mg Ivermecin
Study: NCT06149767

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adebrelimab
Description: The medication regimen for all enrolled patients is as follows, and the dose can be adjusted during treatment due to adverse reactions and other circumstances:~Adebrelimab : 20 mg/kg, D1, intravenously, 30-60 min, Q3w. Paclitaxel for Injection: 150 mg/m2, D1 Cisplatin: 50 mg/m2, IV, D1, Q3w. Radiotherapy: pelvic dose: 6MV-X, 180cGy/ times 27 times; Brachydose: 192Ir, 700cGy/ time 4 times.~First of all, after 2 cycles of concurrent chemoradiotherapy, the sequential chemotherapy combined with adbalizumab for 2-4 cycles, and the subsequent investigators selected Adbalizumab or other drugs to maintain the treatment according to the patient's situation or the patient's own will until the disease progressed or intolerable toxicity occurred or the subjects voluntarily withdrew from the study.adebrelimab until disease progression or intolerable toxicity or the subject voluntarily withdrew from the study。
Study: NCT05675020

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Zoom Intervention
Description: This educational program will be delivered via a 45-minute presentation via Zoom.~* The educational presentation will be recorded and emailed to participants within 1 week of intervention to re-watch/review.~* The educational program will promote a healthy lifestyle knowledge and behaviors through education evidenced by the CDC, WHO, and the American Academy of Pediatrics. Educational sessions will include the importance of healthy lifestyle modifications in the adolescent population with a mental health condition(s), lifestyle recommendations versus reality, nutrition, physical activity, screen time, and sleep recommendations and guidelines.~* We will compare the effects of an educational program on healthy lifestyle knowledge and behaviors pre-and post-program (after one month) via a REDCap survey for the adolescent and their parent/legal guardian.
Study: NCT06309329

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Strength at Home Parents
Description: Strength at Home parents is an 8 week trauma-informed and cognitive behavioral tele-health group intervention that aims to improve parenting behaviors and overall parent-child and family functioning among U.S. military Veterans with post-traumatic stress disorder symptoms

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: VA treatment as usual
Description: VA treatment as usual includes referral to the online resources at veterantraining.va.gov/parenting .
Study: NCT05998928

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine + Cyclophosphamide + BCMA-GPRC5D CAR-T Cells
Description: fludarabine 30 mg/m2 and cyclophosphamide 300 mg/m2 both on three consecutive days during D-7 to D-3~BCMA-GPRC5D CAR-T Cells on day 0
Study: NCT05072470

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Roger microphone
Description: Commercially available transmitter microphone which sends distant speech signals to a receiver that is attached/embedded into hearing aids.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Phonak Audeo hearing aid
Description: Commercially available receiver-in-canal hearing aid
Study: NCT05503121

Intervention type: DIAGNOSTIC_TEST
Intervention: 3D motion analysis, muscle activation, biomarker analysis
Description: Participants with nonspesific low back pain and control group will be analysed with 3D motion analysis sistem, sEMG and will be checked the biomarkers. Then the data will be compared.

Intervention type: DIAGNOSTIC_TEST
Intervention: 3D motion analysis, muscle activation, biomarker analysis
Description: Participants with nonspesific low back pain and control group will be analysed with 3D motion analysis sistem, sEMG and will be checked the biomarkers. Then the data will be compared.
Study: NCT05196178

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Spinal cord stimulation
Description: Paddle-shaped Spinal cord stimulation electrode with 16 contacts (AdaptiveStim® 39, 565;Medtronic, USA) will be implanted into the epidural space at the thoracic levels ranging from T10 to T12.
Study: NCT05895799

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Tuition from a expert clinical trainer
Description: Each group was initially provided with an online tutorial on the complete physical examination of the cardiovascular system as performed on a standardized patient by the trainer. At the beginning of each session, the trainer performed the examination on a hybrid patient wearing the auscultation vest and provided additional teaching, explanations, and rationale. Following the demonstration, each participant was invited to perform repeated physical examinations in front of their peers with real-time one-to-one feedback from the trainer. After each performance, the participant was encouraged to critique their own performance(s), peers were invited to provide some insights, and the trainer gave some overall feedback. At the end of the session and after each participant had had the opportunity to perform the complete examination at least once, the participants were taken through a range of abnormal signs using the auscultation vest with explanations provided by the trainer.
Study: NCT05302518

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive behavioral therapy with exposure in virtual reality
Description: The treatment rationale is based on a model of the maintenance of social phobia by Clark and Wells. The themes of therapy are: a) The general ideas of CBT, b) The maintaining processes of social phobia, c) negative automatic thoughts, d) shifting focus of attention form self-focus to external focus, e) safety behaviors, f) post-processing, g) self-processing, h) schemas and rules for living.~Exposure in VR:~We will use 360° 3D videos for exposure using an HTC Vive Pro headset. Six different videos will be used for exposure: 1) Taking a seat on a bench in a public park, 2) Being introduced as a new employee, 3) Performing a presentation at a meeting, 4) Entering and shopping in a grocery store, 5) Visiting a café and 6) Using public transportation. The therapist can choose the length of the exposure as well as the difficulty of the exposure. While the participant is in the VR-scenario HR and EDA are measured. These data are collected to continuously estimate the anxiety levels.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Cognitive behavioral therapy with exposure in vivo
Description: The treatment rationale is based on a model of the maintenance of social phobia by Clark and Wells.The themes of therapy are: a) The general ideas of CBT, b) The maintaining processes of social phobia, c) negative automatic thoughts, d) shifting focus of attention form self-focus to external focus, e) safety behaviors, f) post-processing, g) self-processing, h) schemas and rules for living.~Exposure in vivo:~Exposure is taking place at Centre for Telepsychiatry and the surrounding areas. The therapist is planning the exposure with the participant and is accompanying the participant during the exposure.
Study: NCT05919212

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: HER2-D is the use of a non-invasive liquid biopsy method to non-invasively and objectively assess HER2 status at recruitment
Description: We study the circulating changes associated with resistance to T-DXd, including changes in HER2 status,studied through a new approach called HER2-2D that simultaneously assesses HER2 amplification and overexpression in blood
Study: NCT06085391

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: REThink Game
Description: REThink Game is the therapeutic game that uses psychological science to help youths find their superhero emotional strengths! It is composed of seven levels, each training a specific emotion regulation ability: emotion recognition, mindfulness and relaxation, cognitive change, positive bias, distinction between useful and useless thoughts, problem solving and compassion.
Study: NCT06300905

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: test product
Description: toothpaste containing 0.45% stannous fluoride

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: test product
Description: toothpaste containing 0.45% stannous fluoride
Study: NCT06085391

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: REThink Game
Description: REThink Game is the therapeutic game that uses psychological science to help youths find their superhero emotional strengths! It is composed of seven levels, each training a specific emotion regulation ability: emotion recognition, mindfulness and relaxation, cognitive change, positive bias, distinction between useful and useless thoughts, problem solving and compassion.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: MoodWheel
Description: Mood Wheel is a web and mobile-based app that uses experience sampling procedures for the assessment of current/previous distress and positive emotions. The aim of the app is to inquire about the valence, control and functionality of users' emotions.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PsyPills
Description: PsyPills is a self-help psycho-educational instrument intended to build stress resilience and to target (only) mild and transient negative mood states, alone or in combination with other methods/instruments.~Psychological Pills (PsyPills) are inspired by Rational-Emotive \& Cognitive-Behavioral Therapy (CBT/REBT), which has strong evidence for its efficacy/effectiveness in human development/health promotion and in the treatment of a variety of psychological conditions.~The PsyPills app was tested in a pilot study and showed positive effects on reducing distress.
Study: NCT05426044

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Metformin
Description: To investigate whether metformin has a neuroprotective effect in patients with primary open-angle glaucoma by comparing the rates of change of average retinal nerve fiber layer ganglion cell inner plexiform layer (RNFL-GCIPL) thickness (primary outcome measure) between patients randomized to receive metformin versus those randomized to receive placebo.~To identify the risk factors associated with progressive RNFL-GCIPL thinning and progressive decline in visual field mean deviation in patients with glaucoma.
Study: NCT06300905

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Control product
Description: toothpaste containing 0.76% sodium monofluorophosphate

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Control product
Description: toothpaste containing 0.76% sodium monofluorophosphate
Study: NCT06230055

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ommaya reservoir
Description: Intrathecal chemotherapy through Ommaya reservoir

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Systematic chemotherapy
Description: Systematic chemotherapy: including capecitabine(1000mg/m2 bid, d1-14, q3w, po), gemcitabine(1000mg/m2, d1,8, q3w, ivgtt), vinorelbine(25mg/m2, d1,8, q3w, ivgtt), docetaxel(75mg/m2, d1, q3w, ivgtt),Nab-paclitaxel(125mg/m2, d1,8, q3w, ivgtt), or iribrin(1.4mg/m2, d1,8, q3w, iv).
Study: NCT05426044

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Metformin
Description: To investigate whether metformin has a neuroprotective effect in patients with primary open-angle glaucoma by comparing the rates of change of average retinal nerve fiber layer ganglion cell inner plexiform layer (RNFL-GCIPL) thickness (primary outcome measure) between patients randomized to receive metformin versus those randomized to receive placebo.~To identify the risk factors associated with progressive RNFL-GCIPL thinning and progressive decline in visual field mean deviation in patients with glaucoma.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: This study takes 24 months. Participants will have 12 visits within 24 months. All of the investigations will be carried out at Grantham Hospital and Hong Kong Eye Hospital. Patients will be randomly assigned in a 1:1 ratio to receive, twice daily, oral metformin 750mg (i.e. 1500mg/day) or identical-appearing oral placebo. The investigators and patients will be blinded to the treatment assignment. Participants will be followed up at 2-month intervals for 24 months.
Study: NCT06230055

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Systematic chemotherapy
Description: Systematic chemotherapy: including capecitabine(1000mg/m2 bid, d1-14, q3w, po), gemcitabine(1000mg/m2, d1,8, q3w, ivgtt), vinorelbine(25mg/m2, d1,8, q3w, ivgtt), docetaxel(75mg/m2, d1, q3w, ivgtt),Nab-paclitaxel(125mg/m2, d1,8, q3w, ivgtt), or iribrin(1.4mg/m2, d1,8, q3w, iv).
Study: NCT06383052

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 177Lu-NYM032 injection
Description: Radionuclide 177Lu will be used as a therapeutic nuclide for this study. The precursor of NYM032 will be labeled with 177Lu to form the chelation product, 177Lu-NYM032 injection which will be used in this study as a intravenous injection dose of 177Lu-NYM032. The radiation dose is chosen within the range of 50-200 mCi for an individual patient at every dose.
Study: NCT05426044

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Placebo
Description: This study takes 24 months. Participants will have 12 visits within 24 months. All of the investigations will be carried out at Grantham Hospital and Hong Kong Eye Hospital. Patients will be randomly assigned in a 1:1 ratio to receive, twice daily, oral metformin 750mg (i.e. 1500mg/day) or identical-appearing oral placebo. The investigators and patients will be blinded to the treatment assignment. Participants will be followed up at 2-month intervals for 24 months.
Study: NCT04500288

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LEFT Device
Description: LEFT device is a novel electronic wearable device that was developed as a sleep position therapy for patients who suffer from nighttime gastroesophageal reflux symptoms. It is simple, noninvasive and low-cost technology which has been developed by Side Sleep Technologies B.V. Singel, Amesterdam, The Netherland.
Study: NCT05609422

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Physical therapy program
Description: * Stretching exercises~* Strength Training Kneeling exercises~* Standing exercises~* Gait Training

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical therapy program
Description: * Stretching exercises~* Strength Training Kneeling exercises~* Standing exercises~* Gait Training

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: scooter board activities
Description: 1. Scooter board bear walk.~2. Scooter board crab walk.~3. Sitting on scooter board, use it to move forward and backward, move the pool rings from one end to another.~4. Cross sitting on scooter board, pulls along the rope using his/her hands~5. Sit with knees pulled into the chest (like a bug pose) and move around with arms only.~6. Prone over scooter board, pulling rope to move forward. Pull self along an anchored rope to retrieve items~7. Scooter rolls outs. Place knees on floor and hands holding the edge of the front scooter board. Push board out a few inches then pull back, the further you roll, the harder it gets.~8. Kneeling, Push self forward and backward with the use of a therapy ball (lots of Motor Planning).~9. Supine flexion on scooter board, Clip clothespins to a rope hanging above.
Study: NCT06511609

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: double-flap technique（DFT）; double-tract reconstruction(DTR),
Description: DFT (experiment group). Patients receive double flap technique after laparoscopic proximal gastrectomy. DTR (control group). Patients receive double-tract reconstruction after laparoscopic proximal gastrectomy.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: double-flap technique（DFT）; double-tract reconstruction(DTR),
Description: DFT (experiment group). Patients receive double flap technique after laparoscopic proximal gastrectomy. DTR (control group). Patients receive double-tract reconstruction after laparoscopic proximal gastrectomy.
Study: NCT05333562

Intervention type: OTHER
Group type: OTHER
Intervention: Motor control exercise
Description: Motor control exercise was given with total of 8 sessions for 30 min for 4 weeks twice a day. Each exercise was performed 10 repetitions for 10 sec.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Motor control exercise with mobilization
Description: this was given motor control exercise for 30 min, 4 weeks twice a day plus neural gliding applied for 3 sets of 10 repetitions on each session. Neural gliding applied 5 min before motor control exercise. Total 8 sessions were given
Study: NCT05400941

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Practice Led Intervention
Description: This is a quality improvement intervention that includes learning collaboratives, practice facilitation, expert consultation and audit and feedback.
Study: NCT06410807

Intervention type: OTHER
Intervention: Focus groups
Description: The present study consists of 5 focus groups over 3 waves to inform the development and refinement of internet-based mindfulness (iMBSR) and lifestyle education (iLifeEd) protocols for use in future clinical trials. 50% females and 50% minoritized participants will be recruited to ensure representation across sex and race. For all focus groups, adults (over the age of 50 years) who report SCD will be recruited. Specifically, the Everyday Cognition Questionnaire (E-Cog) will be administered to quantify informant-reported deficits in cognitive functioning.
Study: NCT05457530

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: DOR/3TC/TDF
Description: 100 mg of doravirine (DOR), 300 mg of lamivudine (3TC), and 300 mg of TDF

Intervention type: COMBINATION_PRODUCT
Group type: ACTIVE_COMPARATOR
Intervention: DOR + FTC/TAF
Description: 100 mg of doravirine + 200 mg emtricitabine (FTC) and 25 mg of tenofovir alefenamide fumerate (TAF)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: BIC/FTC/TAF
Description: Bictegravir sodium 50 mg, emtricitabine 200mg, tenofovir alefenamide fumerate 25mg
Study: NCT05652192

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: SBRT
Description: SBRT was added to systematic treatment (chemo+ PD-1 antibody)
Study: NCT05668650

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pembrolizumab
Description: Study drug administration: intravenous infusion Dosing instructions: 200 mg administered over 30 minutes, every 3 weeks The time for infusion should be closer to 30 minutes. However, considering the variability of the infusion pumps from one center to another, a -5 to +10 minutes window is allowed (ie, the time for infusion is 30 minutes with an allowed range of 25 to 40 minutes).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pembrolizumab biosimilar
Description: Study drug administration: intravenous infusion Dosing instructions: 200 mg administered over 30 minutes, every 3 weeks The time for infusion should be closer to 30 minutes. However, considering the variability of the infusion pumps from one center to another, a -5 to +10 minutes window is allowed (ie, the time for infusion is 30 minutes with an allowed range of 25 to 40 minutes).