Study: NCT05094206

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 0.75x10^6 cells/kg CAR20.19.22 cells
Description: Dose escalation: CAR20.19.22 cells will be administered at one of three dose levels either fresh or thawed after cryopreservation by IV injection.~Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 0.75x10^6 cells/kg CAR20.19.22 cells
Description: Dose escalation: CAR20.19.22 cells will be administered at one of three dose levels either fresh or thawed after cryopreservation by IV injection.~Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 1x10^6 cells/kg CAR20.19.22 cells
Description: CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.~Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 1x10^6 cells/kg CAR20.19.22 cells
Description: CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.~Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 2.5x10^6 cells/kg CAR20.19.22 cells
Description: CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.~The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 2.5x10^6 cells/kg CAR20.19.22 cells
Description: CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.~The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 5x10^6 cells/kg CAR20.19.22 cells
Description: CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.~The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: 5x10^6 cells/kg CAR20.19.22 cells
Description: CAR20.19.22 cells will be administered at one of four dose levels either fresh or thawed after cryopreservation by IV injection.~The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Dose expansion: The maximum tolerated dose of CAR20.19.22 cells
Description: Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6 cells/kg.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Dose expansion: The maximum tolerated dose of CAR20.19.22 cells
Description: Dose expansion: The maximum tolerated dose intervention will be updated when it is determined. It will be one of four doses: 0.75x10\^6 cells/kg, 1x10\^6 cells/kg, 2.5x10\^6 cells/kg or 5x10\^6 cells/kg.