TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05799755

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Nintedanib
Description: Nintedanib 150 mg BID

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Nintedanib
Description: Nintedanib 150 mg BID

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo comparator

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Standard of Care
Description: Maximum of 2 standard of care immunosuppressant (IS) drugs are allowed, one being a glucocorticoid (GC) and the other being a non-GC IS drug OR 2 non-GC IS drugs in the event that the patient is not on a GC). The patient should be on the IS drug(s) for at least 12 weeks (at least 4 weeks or more for GC) before the screening. The doses should be stable for at least 4 weeks (at least 2 weeks for GC) before the screening visit.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Standard of Care
Description: Maximum of 2 standard of care immunosuppressant (IS) drugs are allowed, one being a glucocorticoid (GC) and the other being a non-GC IS drug OR 2 non-GC IS drugs in the event that the patient is not on a GC). The patient should be on the IS drug(s) for at least 12 weeks (at least 4 weeks or more for GC) before the screening. The doses should be stable for at least 4 weeks (at least 2 weeks for GC) before the screening visit.
Study: NCT05662215

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CK-3828136
Description: CK-3828136

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CK-3828136
Description: CK-3828136

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CK-3828136
Description: CK-3828136

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo for CK-3828136
Description: Placebo for CK-3828136
Study: NCT06367192

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: The adapted Kids in Transition to School Intervention
Description: An intensive, school readiness intervention designed to improve preschoolers' early literacy, numeracy, and self-regulation skills at high risk for academic difficulties. The intervention is delivered virtually over 8 weeks with caregivers and intentionally occurs over the summer when there is a gap in preschool services.

Intervention type: DEVICE
Group type: OTHER
Intervention: Standard school resources
Description: Information about local preschool programs and age appropriate books for children will be provided.
Study: NCT06647836

Intervention type: OTHER
Intervention: Efficacy observation
Description: Observation about the efficacy of sq-NSCLC patients receiving immunotherapy combined with or without chemotherapy as first-line treatment.

Intervention type: OTHER
Intervention: Efficacy observation
Description: Observation about the efficacy of sq-NSCLC patients receiving immunotherapy combined with or without chemotherapy as first-line treatment.

Intervention type: OTHER
Intervention: Efficacy observation
Description: Observation about the efficacy of sq-NSCLC patients receiving immunotherapy combined with or without chemotherapy as first-line treatment.

Intervention type: OTHER
Intervention: Efficacy observation
Description: Observation about the efficacy of sq-NSCLC patients receiving immunotherapy combined with or without chemotherapy as first-line treatment.
Study: NCT06372470

Intervention type: OTHER
Intervention: Zestril
Description: N/A, this is an observational study.
Study: NCT05326529

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Hospital Based Cardiac Rehabilitation Exercise Classes
Description: Participants will attend 8 Hospital based CR exercise sessions. QOL and Hospital anxiety and Depression scores through questionnaires and incremental Shuttle Walk tests will be carried out pre and post intervention.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hospital Based Cardiac Rehabilitation Exercise Classes
Description: Participants will attend 8 Hospital based CR exercise sessions. QOL and Hospital anxiety and Depression scores through questionnaires and incremental Shuttle Walk tests will be carried out pre and post intervention.
Study: NCT05662215

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo for CK-3828136
Description: Placebo for CK-3828136
Study: NCT06061497

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Abdomino-diaphragmatic breathing
Description: Breathing should be done twice a day for 10 minutes.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Usual Care
Description: Health education Review of inhaler technique Check adherence to treatment; Presence of comorbidities; Smoking; Other environmental factors; Promotion of physical activity

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Usual Care
Description: Health education Review of inhaler technique Check adherence to treatment; Presence of comorbidities; Smoking; Other environmental factors; Promotion of physical activity
Study: NCT05607095

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Lifileucel (LN-144/LN-145)
Description: Lifileucel (LN-144/LN-145) is an autologous Tumor Infiltrating Lymphocytes (TIL) cell therapy that utilizes a 22-day centralized GMP process. Lifileucel is infused as part of a treatment regimen that includes preparative NMA-LD, followed by one-time autologous TIL infusion, and a short course of high-dose IL-2.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Lifileucel (LN-144/LN-145)
Description: Lifileucel (LN-144/LN-145) is an autologous Tumor Infiltrating Lymphocytes (TIL) cell therapy that utilizes a 22-day centralized GMP process. Lifileucel is infused as part of a treatment regimen that includes preparative NMA-LD, followed by one-time autologous TIL infusion, and a short course of high-dose IL-2.
Study: NCT06417554

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-A2102
Description: SHR-A2102

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR-A2102 ; Adebrelimab injection
Description: SHR-A2102 + Adebrelimab injection
Study: NCT06123286

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tart Cherry
Description: 1 ounce of Tart Cherry Concentrate (King Orchard) mixed with 8 ounces of water daily for 12 weeks
Study: NCT04705909

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pitavastatin
Description: Pitavastatin 2 mg oral tablets daily will be given to the patients concomitantly with the intended chemotherapy protocol for the treatment period prior to surgery.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: patients in this group will receive placebo tablets concomitantly with the intended chemotherapy for the treatment period prior to surgery.
Study: NCT05326529

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Web-based Cardiac Rehabilitation Exercise Sessions
Description: Participants will complete 8 weeks of Web-based CR exercise sessions using the MyHeart app. QOL and Hospital anxiety and Depression scores through questionnaires and incremental Shuttle Walk tests will be carried out pre and post intervention.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Web-based Cardiac Rehabilitation Exercise Sessions
Description: Participants will complete 8 weeks of Web-based CR exercise sessions using the MyHeart app. QOL and Hospital anxiety and Depression scores through questionnaires and incremental Shuttle Walk tests will be carried out pre and post intervention.
Study: NCT06123286

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Omega 3 FA (Fish Oil)
Description: 2 capsules of Omega 3 FA (Fish Oil) (Nordic Naturals Ultimate Omega) \[650 mg EPA and 450 mg DHA per capsule\] daily for 12 weeks
Study: NCT05086133

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: transcranial magnetic stimulation
Description: transcranial magnetic stimulation with continuous theta burst pattern, 90% RMT, 50Hz within train and 5Hz train for 200 train and 40 second in total.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: sham stimulation
Description: TMS coil vertical to the brain surface, with same protocol as cTBS
Study: NCT05381974

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Psilocybin
Description: Open-Label
Study: NCT05822115

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Reduction of breast hypertrophy by means of laparoscopic
Description: The research procedure is a breast reduction performed by means of laparoscopic surgery.~The project consists of removing a disc from the breast at the level of the base, thus causing peripheral skin slackening of 2 to 3 cm but circular. Both breasts are usually operated on at the same time. In case of asymmetry, only one side will be treated.
Study: NCT06217328

Intervention type: DEVICE
Group type: OTHER
Intervention: Revi System Treatment
Description: The Revi System is an implantable neuromodulation device placed in the ankle region that is activated by a battery-operated rechargeable external wearable

Intervention type: DEVICE
Group type: OTHER
Intervention: Revi System - Delayed Activation
Description: The Revi System is an implantable neuromodulation device placed in the ankle region that is activated by a battery-operated rechargeable external wearable. The system will be implanted but it will not be turned on until 4 months post implant procedure.
Study: NCT05615649

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MED-EL BONEBRIDGE Bone Conduction Implant
Description: Subjects will be implanted with the MED-EL BONEBRIDGE Bone Conduction Implant System. Subjects will be fit with the appropriate external audio sound processor.
Study: NCT05916651

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Learning to Offset Stress (LOS) (in Dutch: Leren Omgaan met Stress) training
Description: The investigational treatment is the LOS training, which is an adaptation of two previously validated mindfulness-based programs: Mindfulness-Based Cognitive Therapy (MBCT) developed by Segal, Williams, and Teasdale (2002) and the Mindful2Work (M2W) program developed by de Bruin, Formsma, and Bögels (2018). The M2W program combines mindful physical activity, yoga, and mindfulness meditation to target stress symptoms and burn-out in adults. The LOS training was adapted from these programs to meet the needs of youth with internalizing problems. The training consists of 8 weekly 2-hour sessions that each comprise three elements: mindful physical activity (15-20 minutes), yoga (15-20 minutes), and mindfulness meditation exercises (80-90 minutes). In addition to attending group sessions, participants are invited to practice at home on a daily basis. Home practice consists of daily mindfulness practices comprising mindfulness exercises, yoga and mindful physical activity.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Care as usual
Description: Youth who seek help for internalizing problems from a primary mental health practitioner, including student psychologists or mental health nurse practioners, but do not (yet) meet criteria for (major) mental illness are typically offered supportive counselling, aimed primarily at helping people feel understood and supported. Supportive counselling may also include instructions on behavioral activation, particularly when individuals report reduced activity and behavioral avoidance including social withdrawal. In addition, mental health practitioners commonly employ a watchful waiting policy for people with symptoms in the milder range, where they check-in with clients on a regular basis and refer for more intensive treatment if and when symptoms worsen.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Care as usual
Description: Youth who seek help for internalizing problems from a primary mental health practitioner, including student psychologists or mental health nurse practioners, but do not (yet) meet criteria for (major) mental illness are typically offered supportive counselling, aimed primarily at helping people feel understood and supported. Supportive counselling may also include instructions on behavioral activation, particularly when individuals report reduced activity and behavioral avoidance including social withdrawal. In addition, mental health practitioners commonly employ a watchful waiting policy for people with symptoms in the milder range, where they check-in with clients on a regular basis and refer for more intensive treatment if and when symptoms worsen.
Study: NCT04909801

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Abatacept
Description: Abatacept SC (125 mg) once weekly

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Abatacept
Description: Abatacept SC (125 mg) once weekly

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adalimumab
Description: Adalimumab SC (40 mg) once every 2 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methotrexate
Description: Methotrexate oral/parenteral maximum tolerated dose (minimum 15 mg and maximum 25 mg weekly)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methotrexate
Description: Methotrexate oral/parenteral maximum tolerated dose (minimum 15 mg and maximum 25 mg weekly)
Study: NCT04998357

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Endovascular autologous mitochondrial transplantation
Description: During standard-of-care endovascular reperfusion procedure, subjects will have autologous mitochondria infused via microcatheter into ischemic brain.
Study: NCT06141148

Intervention type: DIAGNOSTIC_TEST
Intervention: sputum analysis
Description: sputum analysis to diagnose tuberculosis

Intervention type: DIAGNOSTIC_TEST
Intervention: lymph node biobsy
Description: to diagnose tuberculous lymphadenitis
Study: NCT06058650

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biopsy of Breast
Description: Undergo biopsy of breast

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Medical Device Usage and Evaluation
Description: Utilization of the Stereo Navigator accessory

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Scintimammography
Description: Undergo MBI

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Scintimammography
Description: Undergo MBI

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Technetium Tc-99m Sestamibi
Description: Given IV

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Technetium Tc-99m Sestamibi
Description: Given IV
Study: NCT04099108

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Combined cycle ergometry and bolus amino acid supplementation
Description: A 4-hour bolus amino acid supplement administered within 30 minutes after a 30-minute in-bed cycling session.
Study: NCT06369389

Intervention type: OTHER
Intervention: Patients eligible for CAR-T treatment
Description: Patients eligible for CAR-T treatment for their hemopathy at TOULOUSE University Hospital under early access or marketing authorization or as part of a clinical trial between 01/01/2019 and 31/12/2028
Study: NCT04453631

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: active tDCS
Description: 26 transcranial direct current stimulation sessions, each lasting 20 minutes, with a current intensity of 2 mA, the cathode placed over the right dorsolateral prefrontal cortex and the anode placed over the left deltoid muscle.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: active tDCS
Description: 26 transcranial direct current stimulation sessions, each lasting 20 minutes, with a current intensity of 2 mA, the cathode placed over the right dorsolateral prefrontal cortex and the anode placed over the left deltoid muscle.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: sham tDCS
Description: tDCS is controlled in this intervention: sham mode.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: sham tDCS
Description: tDCS is controlled in this intervention: sham mode.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CBT-UP
Description: 15 psychotherapy sessions (1/week) following the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders developed by Barlow et al. 2018.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CBT-UP
Description: 15 psychotherapy sessions (1/week) following the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders developed by Barlow et al. 2018.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Psychoeducation
Description: To control for the cognitive-behavioral intervention we will use psychoeducation materials.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Psychoeducation
Description: To control for the cognitive-behavioral intervention we will use psychoeducation materials.
Study: NCT06429254

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Experimental group
Description: Life Scale will be administered as pre-tests to the EFT group. After the pre-tests, the first EFT session will be conducted. A second EFT session will take place 30 days later, followed by post-tests. During this period, affirmations will be provided as needed based on individual difficulties, perspectives, support systems, past traumas, and emotional blockages experienced by the woman. Each session is planned to last approximately 45 minutes to 1 hour.
Study: NCT05053620

Intervention type: DEVICE
Intervention: Calculation of the arcuate intrasomal incisions
Description: All patients participating in the study will undergo femtosecond laser treatment for the correction of astigmatism through arcuate intrastromal incisions with the Catalys laser (Johnson \& Johnson, USA, CE marked). The calculation of intrastromal arcuate incisions will be carried out using the following nomogram indicated on the laser: 9.0 mm optical zone and symmetrical incisions of 50 degrees for 0.50D, 55 degrees for 0.75D, 60 degrees for 1.00D and 65 degrees for 1.25D of corneal astigmatism. After the incisions, conventional cataract surgery will be performed using the Centurion phacoemulsifier equipment (Alcon, USA, with CE marking) in the ZCB00 monofocal intraocular lens (IOL) implant (Johnson \& Johnson, USA, with CE marking). All patients will be treated according to standard clinical practice.
Study: NCT05506566

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 68Ga-FAP-CHX
Description: The dose will be 0.05 (mCi / kg) +/- 10% given intravenously at a single time prior to imaging
Study: NCT05011851

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NNZ-2591
Description: NNZ-2591 oral solution (50mg/mL) to be administered twice daily for 13 weeks.
Study: NCT04949373

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: High-intensity laser therapy (HILT)
Description: High intensity laser therapy-Patients will receive pulsed laser treatment, using a HIRO 3 device (ASA Laser, Arcugnano, Italy), five times a week for a period of three weeks, and one session per day for a total of 15 sessions. A 3-phase treatment program will be performed on each session.~Other: Tendon and nerve gliding exercises will be performed three times a day with 10 repetitions each time for 3 weeks. Exercises will be performed by a trained physiotherapist.~Other: Rest splint(at night) Participants will be splinted in neutral position with standard cotton-polyester splints.The patients will be encouraged to use the splints during nighttime for 12 weeks.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham High-intensity laser therapy (sham HILT)
Description: Sham high intensity laser therapy-Participants will receive pulsed laser treatment, using a HIRO 3 device (ASA Laser, Arcugnano, Italy), five times a week for a period of three weeks, and one session per day for a total of 15 sessions.~Other: Tendon and nerve gliding exercises will be performed three times a day with 10 repetitions each time for 3 weeks. Exercises will be performed by a trained physiotherapist.~Other: Rest splint(at night) Participants will be splinted in neutral position with standard cotton-polyester splints.The patients will be encouraged to use the splints during nighttime for 12 weeks.
Study: NCT06498765

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pacifier Use
Description: The newborns in the experimental group were given a pacifier, unlike the control group. The newborns were placed in a phototherapy incubator and each time they were placed in a phototherapy incubator, the newborns were given a pacifier for an average of 5 minutes. The researcher encouraged the babies to take the pacifier.
Study: NCT06545968

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: A social media based intervention
Description: WatsApp-based modules to influence retention in care behaviour
Study: NCT05491148

Intervention type: OTHER
Intervention: work conditions
Description: an increased degree of responsibility for the life of newborns, high psycho-emotional stress, intellectual stress, an irrational work and rest regime, in connection with the COVID-19 pandemic, also using personal protective equipment against biological factors
Study: NCT05478655

Intervention type: OTHER
Intervention: visual analog scale
Description: VAS was studied: 1) before and after anesthesia - at the stage of the medical and nursing brigade, military mobile hospital, military medical clinical center; 2) at the stage of the medical and nursing team - within 2 days; 3) at the stage of the military mobile hospital - within 5 days; 4) at the stage of the military medical clinical center - within 7 days, at the time of discharge from the hospital and further 1, 3, 6, 12 months after the injury; 5) at the rehabilitation stage. Intervals between analgesia were also studied.

Intervention type: OTHER
Intervention: visual analog scale
Description: VAS was studied: 1) before and after anesthesia - at the stage of the medical and nursing brigade, military mobile hospital, military medical clinical center; 2) at the stage of the medical and nursing team - within 2 days; 3) at the stage of the military mobile hospital - within 5 days; 4) at the stage of the military medical clinical center - within 7 days, at the time of discharge from the hospital and further 1, 3, 6, 12 months after the injury; 5) at the rehabilitation stage. Intervals between analgesia were also studied.
Study: NCT06561204

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FMET
Description: A full-mouth electronic toothbrush

Intervention type: DEVICE
Group type: OTHER
Intervention: FMET
Description: A full-mouth electronic toothbrush
Study: NCT06461416

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ActiveHeal
Description: Participants will have 6 group activity sessions and six individualized sessions from home, all focused on optimizing persistence in performance of specific selected activities.
Study: NCT06102044

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Zinc Supplements
Description: Dispersible zinc sulfate tablets

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Supplements
Description: Dispersible placebo tablets
Study: NCT06024564

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Sonu Acoustic Resonance Therapy
Description: Participants will receive Sonu treatment twice a day for 90 days
Study: NCT05575076

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Simufilam
Description: simufilam 100 mg oral tablet, twice daily