Study: NCT06080932

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: NIH Toolbox
Description: IPAD-based assessments that examines cognitive function

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: gradCPT
Description: The gradCPT contains grayscale photographs of mountain scenes and city scenes. Scene images gradually transition from one image to the next

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Resting-state fMRI
Description: Whole brain echo-planar imaging (EPI) volumes sensitive to the BOLD signal will be acquired. Images will be re-aligned, un-warped, and normalized. Confounding effects of white matter, CSF signal, and head motion will be regressed from the functional time series, followed by bandpass filtering, linear detrending and smoothing, and whole brain resting state networks will be identified (e.g., default mode network, salience network, etc).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Task-fMRI
Description: During whole brain EPI data acquisition, participants will be presented with words and pictures and asked to make judgements about the stimuli, such as indicating whether a particular stimulus (e.g., face-name association, word, number, or letter) has been previously presented, if a presented stimulus is a city or mountain scene, the direction an arrow is pointing (left or right), if a pair of stimuli match (e.g., faces with neutral or emotional expressions; word with a face). Behavioral responses will be recorded with an MRI compatible button box.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: CGM/CKM
Description: Continuous Ketone/Glucose Monitor will be applied at the start of Test Day 1. The sensor will be checked by the study team at each test day and will be removed and replaced by a fresh sensor at \~2- week intervals during the study. The sensor will be removed at the end of the final test day.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Blood Draw
Description: Blood samples will be collected according to the schedule in Figure 1

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sleep Monitoring
Description: Sleep will be assessed by ring-based acceleration with cloud technology (Oura Ring). This monitor is less burdensome than other sleep monitoring technologies and less likely to interfere with normal sleep and activity demands. Worn daily throughout intervention

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ketone/Glucose Monitoring
Description: KetoMojo hand-held glucometer will be used daily to monitor dietary intervention adherence.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Body Composition
Description: DEXA Scanning will be done pre-, mid-, and post- intervention.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PHQ-9
Description: It is a self-assessment tool used to screen and assess the severity of depression in individuals. The PHQ-9 consists of nine questions based on the nine criteria for diagnosing major depressive disorder in the Diagnostic and Statistical Manual of Mental Disorders (DSM-5).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: WHO-5
Description: The WHO-5, also known as the World Health Organization-Five Well-Being Index, is a self-assessment tool used to measure subjective well-being and mental health. It was developed by the World Health Organization (WHO) as a brief and reliable instrument to evaluate well-being in clinical and research settings.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SKID
Description: The SKID refers to the Structured Clinical Interview for DSM Disorders (SCID). It is a widely used diagnostic tool in the field of psychiatry and clinical psychology. The SCID is a semi-structured interview designed to assess and diagnose various mental disorders according to the criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders (DSM), which is published by the American Psychiatric Association.