TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05133596

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinical examination
Description: The investigator will conduct a clinical examination to rule out other causes of olfactory impairment independent of COVID-19. The investigator will also collect the following information: socio-demographic data (age, sex, blood type, weight, height, etc.), history of olfaction disorder symptoms, past or current treatments received and tobacco/alcohol consumption.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood collection
Description: 12ml-blood sample

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Olfactory evoked potentials
Description: Olfactory evoked potentials will be recorded during olfactory tests.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Brushing of olfactory slits
Description: collection of olfactory slits cells.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Neurological examination and neuropsychological assessment
Description: * MOCA, BREF~* CVLT~* WAIS IV, MEM III~* Right-side and left-side empan, Trail Making Test A and B (TMT), verbal fluency tests, PASAT, Attention Assessment Test~* Benton's Line Judgement, VOSP~* Assessment of psychological status, fatigue and screening for psychiatric comorbidities: depression \& anxiety scales (HAD scale, mADRS depression scale, STAI anxiety scale), Fatigue Severity Scale.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Nasal endoscopy
Description: Nasal endoscopy

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Assessment of olfactory and taste functions
Description: * scales: VAS and TSS~* Sniffin Stick test
Study: NCT04929483

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BIO89-100
Description: Subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BIO89-100
Description: Subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BIO89-100
Description: Subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BIO89-100
Description: Subcutaneous injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subcutaneous injection

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Subcutaneous injection
Study: NCT06149533

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Edoxaban
Description: Edoxaban, an oral selective factor Xa inhibitor, had been approved by the National Medical Products Administration in 2018. It is used for the treatment and recurrence prevention of deep venous thrombosis (DVT) and pulmonary embolism (PE) in adults.
Study: NCT06585501

Intervention type: OTHER
Intervention: No drug
Description: This is a non-interventional study and no study drug will be provided.
Study: NCT04198272

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CyberRwanda
Description: The CyberRwanda intervention consists of three primary components: 1. STORIES: The CyberRwanda curriculum empowers youth to learn about family planning and reproductive health and employment skills and to set goals for their futures through age-appropriate, interactive, digital and printed stories and activities. 2. LEARN: Q\&As and videos related to family planning and reproductive health. 3. SHOP: Youth can directly purchase health products, including menstrual hygiene and contraceptive products (emergency contraception, condoms, and oral contraceptive pills) online. The online health facility finder tool links youth to health facilities for longer-acting methods. All participating pharmacies will be trained to give unbiased, nonjudgmental information and services.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CyberRwanda
Description: The CyberRwanda intervention consists of three primary components: 1. STORIES: The CyberRwanda curriculum empowers youth to learn about family planning and reproductive health and employment skills and to set goals for their futures through age-appropriate, interactive, digital and printed stories and activities. 2. LEARN: Q\&As and videos related to family planning and reproductive health. 3. SHOP: Youth can directly purchase health products, including menstrual hygiene and contraceptive products (emergency contraception, condoms, and oral contraceptive pills) online. The online health facility finder tool links youth to health facilities for longer-acting methods. All participating pharmacies will be trained to give unbiased, nonjudgmental information and services.
Study: NCT06399640

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Eltanexor
Description: Eltanexor will be taken by mouth

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Venetoclax will be taken by mouth

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone Marrow Aspiration and Biopsy
Description: Undergo bone marrow aspiration and biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Biospecimen Collection
Description: Undergo blood sample collection
Study: NCT04342715

Intervention type: DRUG
Intervention: Sodium stibogluconate / paramomycin
Description: Treatment with Sodium stibogluconate / paramomycin
Study: NCT06292832

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound-guided pain block
Description: Ultrasound-guided pain block after cesarean section

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound-guided pain block
Description: Ultrasound-guided pain block after cesarean section

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound-guided pain block
Description: Ultrasound-guided pain block after cesarean section

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound-guided pain block
Description: Ultrasound-guided pain block after cesarean section

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound Machine
Description: Ultrasound machine used to guide the nerve block.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound Machine
Description: Ultrasound machine used to guide the nerve block.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound Machine
Description: Ultrasound machine used to guide the nerve block.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound Machine
Description: Ultrasound machine used to guide the nerve block.
Study: NCT05065008

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cranberry juice
Description: The responders and non-responders will drink 20-30 oz of (590-885 mL) 27% cranberry juice daily for 3 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Apple juice
Description: The participants will drink apple juice with matching sugar content and calories for 3 weeks
Study: NCT05842278

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: 4 session rTMS
Description: Participants will receive 4 sessions per day of 1800 pulses per session, lasting for 5 days. Individualized targets will be generated using the pBFS method.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: 6 session rTMS
Description: Participants will receive 6 sessions per day of 1800 pulses per session, lasting for 5 days. Individualized targets will be generated using the pBFS method.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: 8 session rTMS
Description: Participants will receive 8 sessions per day of 1800 pulses per session, lasting for 5 days. Individualized targets will be generated using the pBFS method.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: 10 session rTMS
Description: Participants will receive 10 sessions per day of 1800 pulses per session, lasting for 5 days. Individualized targets will be generated using the pBFS method.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: sham rTMS
Description: The parameters in the sham arms are the same as the active stimulation groups. Stimulation was delivered by the same device as the active group fitted with a sham coil.
Study: NCT06212934

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Acupuncture
Description: Chou's Tiaoshen acupoints includes Baihui (GV-20), Shenting (GV-24), and Sishencong (EX-HN1), Sanyinjiao (SP-6), Shenmen (HT-7) . Using stainless steel needles (0.32×40)mm, HuaTuo, China). Then some other points like, Danzhong(CV-17), Daling(PC-7), Taixi (KI-3), Qihai (CV-6), Taichong (LR3), and Qiuxu(GB-40) are chosen. Operation: Patients in supine position. Baihui (GV-20), Shenting (GV-24), and Sishencong (EX-HN1) are punctured at a depth of 20-25mm obliquely. Sanyinjiao (SP-6) and Shenmen (HT-7) are inserted 15mm perpendicularly. Until feeling tactile sensation then manually manipulated by rotation methods to produce a characteristic sensation known as De Qi; Technique: Mild reinforcing and attenuating, retaining the needle for 30minutes. The treatment will be givenonce a day and 5 times a week in weekdays, the course will last two weeks.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estazolam
Description: Participants will take estazolam 1mg 30min prior to bedtime everyday. The course of treatment is two weeks.
Study: NCT06111716

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mindfulness- Based Childbirth Education
Description: Mindfulness- Based Childbirth Education Group includes; Women were given eight-week birth preparation training. In this training, in addition to information about birth, mindfulness, mindfulness attitudes and practices, mindfulness in daily life, mindfulness in pregnancy and postpartum period, mindfulness breastfeeding and meditation practices were included.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Information-Based Birth Education
Description: In the Information-Based Birth Education Group, women were given 4-week (4 hours per week) birth preparation training. The education given was not based on a philosophy or method.
Study: NCT06535971

Intervention type: OTHER
Group type: OTHER
Intervention: Manual therapy combined exercise
Description: 1. Manual therapy included fascia release, progressive passive stretch, mobilization, etc.(depend on subject's current condition)~2. Exercise included muscle strengthening, trunk (spine) stabilization exercise. (depend on subject's current condition)
Study: NCT05476146

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rerouting of the track in high anal fitula
Description: Treatment of high anal fistula by rerouting
Study: NCT05909631

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Beetroot juice
Description: 250 ml of concentrated beetroot juice, were given to participants in the BJ groups .This was carried out in the morning, 30 minutes before breakfast, and on an empty stomach.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: 250 ml of a placebo

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mediterranean diet alone (MeD)
Description: Mediterranean diet alone (MeD)

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Mediterranean diet with beet juice (BJ+MeD)
Description: Mediterranean diet with beet juice (BJ+MeD).
Study: NCT05668728

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Group 1: Peppering
Description: Before injection we will palpate the muscles of trapezius, m. rhomboideus, m. levator scapula for finding painful trigger points, and we will mark the point. the skin will be cleaned with an appropriate antiseptic. Before the needle is inserted, the area to be applied will be palpated once again to detect the painful trigger point between the thumb and index fingers. The needle will be guided to painful trigger points detected by palpation. Stainless steel 25x25 mm needles will be used for dry needling. The needle will be inserted and removed until the local twitch response disappears, at least 10 times at each point found. Afterwards, the patient will be given a standard exercise program for the neck muscles. With this method, dry needling will be applied to the patient 4 times a week, once a week.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: group 2: spin and wait
Description: Just before the injection, painful trigger points in the bilateral muscles of trapezius, m. rhomboideus, and m. levator scapula will be identified and marked by palpation, and the skin will be cleaned with an appropriate antiseptic. Before the needle is inserted, the area to be applied will be palpated once again to detect the painful trigger point between the thumb and index fingers. The needle will be guided to painful trigger points detected by palpation. Stainless steel 25x25 mm needles will be used for dry needling. After the dry needle is inserted at each point found, it will be spinned counterclockwise and left. Waiting time for each patient will be limited to 15 minutes. Afterwards, the patient will be given a standard exercise program for the neck muscles. With this method, dry needling will be applied to the patient 4 times a week, once a week.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: group 3: Peppering and spin and wait
Description: Just before the injection, painful trigger points in the bilateral muscles of trapezius, m. rhomboideus, and m. levator scapul will be identified and marked with palpation, and the skin will be cleaned with an appropriate antiseptic. Before the needle is inserted, the area to be applied will be palpated once again to detect the painful trigger point between the thumb and index fingers. The needle will be guided to painful trigger points detected by palpation. Stainless steel 25x25 mm needles will be used for dry needling. After the needle is inserted and removed, it will be spinned counterclockwise for 15 minutes in each patient until the local twitch response disappears, at least 10 times at each point found. Afterwards, the patient will be given a standard exercise program. With this method, dry needling will be applied to the patient 4 times a week, once a week.
Study: NCT06580132

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Pectin
Description: Pectin fibre (20g) was randomly allocated to eligible participants in order to test specific effects on gut microbiome composition and metabolic markers.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Maltodextrin
Description: Maltodextrin (10g) served as a control/ placebo to compare the effects observed with pectin.
Study: NCT05049772

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Telerehabilitation-based motor imagery training
Description: 10 weeks of motor imagery training and stabilization exercises.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Stabilization exercises group
Description: 10 weeks of stabilization exercises.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stabilization exercises group
Description: 10 weeks of stabilization exercises.
Study: NCT05061004

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cephea Mitral Valve System
Description: Transcatheter mitral valve replacement
Study: NCT05992142

Intervention type: DRUG
Group type: OTHER
Intervention: 5-ASA
Description: Assessment of the different levels of remission (clinical, endoscopic, histological) in UC patients treated only by 5-ASA, who report to be in clinical remission during a routine follow-up visit
Study: NCT06266195

Intervention type: DIAGNOSTIC_TEST
Intervention: sierological test
Description: sierological test: circulant vescicles

Intervention type: DIAGNOSTIC_TEST
Intervention: sierological test
Description: sierological test: circulant vescicles
Study: NCT06634745

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard Needle Irrigation (SNI)
Description: Standard Needle Irrigation (SNI):~Utilizes standard needle irrigation techniques for activating the antimicrobial solution within the root canal.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Passive Ultrasonic Irrigation (PUI
Description: Passive Ultrasonic Irrigation (PUI):~Employs ultrasonic energy to enhance the activation and effectiveness of the antimicrobial solution in the root canal.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: EndoActivator (EA)
Description: EndoActivator (EA):~Uses a sonic activation device to facilitate the distribution and activation of the antimicrobial solution in the root canal.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: EDDY
Description: EDDY:~Involves the use of a sonic activation device that operates at high frequency to activate the antimicrobial solution within the root canal.~These descriptions focus on the general method and purpose of each intervention without delving into the specific procedural details already covered in the arm/group descriptions.
Study: NCT05642312

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vamikibart
Description: Participants will receive vamikibart IVT injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vamikibart
Description: Participants will receive vamikibart IVT injection

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Sham
Description: Participants will receive a sham procedure that mimics an IVT injection.
Study: NCT05607108

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ZEN003694
Description: ZEN003694 60mg po qd on a 5 days on 2 days off schedule in an every 21-day cycle
Study: NCT04951492

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Olaparib
Description: Given PO
Study: NCT04531046

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: axicabtagene ciloleucel
Description: Patient-specific (autologous) product cryopreserved in cryostorage bag
Study: NCT06511232

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intraosseous Morphine
Description: More recently, intraosseous infusion of analgesics and antibiotics has gained traction in the total joint arthroplasty literature. In knee arthroplasty patients, the combination of a spine and adductor canal block with an intraosseous infusion of morphine into the tibial tubercle prior to incision yielded lower pain in the immediate postoperative period and at 2 weeks, less pain medication use, and significantly better patient-reported outcomes while also reducing systemic opioid exposure in the early postoperative period compared to the spine and adductor block alone.3 No study to date in the available literature has evaluated the efficacy of intraosseous morphine infusion in managing acute postoperative pain in patients undergoing ACL reconstruction with bone-patellar tendon-bone autograft, so that is the intended evaluation point with this project.
Study: NCT06038123

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: China market released 3.0T Magnetic resonance (MR) conditional CIED systems
Description: To confirm safety and effectiveness of the SureScan CIED System in the clinical MRI environment when subjects receive 3.0T MRI scans without positioning restrictions (MRI scans may occur anywhere on the body)
Study: NCT06039020

Intervention type: DRUG
Intervention: Anti-human thymocyte immunoglobulin, equine
Description: Usually, 40 mg of anti-human thymocyte immunoglobulin, equine per kilogram of body weight should be slowly administered by intravenous drip infusion once daily. The duration of treatment should be 4 days.
Study: NCT06424249

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Reality
Description: A progressive rehabilitation protocol (different levels according to success scores) consisting of several exercises using virtual and augmented reality with mechanical perturbations (pitching of the treadmill), interaction with the virtual environment, interaction with the virtual environment and augmented reality (projection of obstacles on the treadmill), and modification of the gait pattern with visual and/or audio biofeedback

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard rehabilitation
Description: A treadmill walking protocol with virtual reality to immerse the patient in a 3 x 5-minute walking session, without visual, mechanical or auditory disturbances, and without prompting the patient to modify their walking pattern.
Study: NCT05240014

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Modular powered orthosis
Description: This study will investigate modular, lower-limb, powered orthoses that fit to user-specific weakened joints and control force/torque in a manner that enhances voluntary motion in broad patient populations. The central hypothesis is that high-torque, low-inertia motor systems controlled with energetic objectives will enable modular powered orthoses to partially assist the joints. High-torque electric motors combined with minimal transmissions can be freely rotated (i.e., backdriven) by human joints, allowing the use of an emerging torque control method called energy shaping to reduce the perceived weight/inertia of the body during any motion. By mounting these modular actuators to commercial orthoses, this technology will be easily prescribed/configured by clinicians.
Study: NCT06636604

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: DSA(Decision Support Algorithm)
Description: Intramuscular injection will be given to 30 volunteer patients using the decision support algorithm.
Study: NCT06634446

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: a mobile application for cognitive training
Description: Personalized cognitive training (PCT) HappyNeuronwill be delivered via a tablet or mobile application for 24 hours within 12 weeks, with a weekly supervision-call to reinforce their motivation.~HappyNeuron Pro is a digital therapy tool designed for clinicians to provide engaging cognitive therapy via a web-based platform. It is compatible with PC, Mac, iPad, and Android devices and is available in multiple languages. The tool features exercises from established cognitive remediation programs.~Functionality: The program offers 22 cognitive exercises targeting seven key functions outlined in the MATRICS framework: Processing Speed, Selective Attention, Reasoning and Working Memory, Verbal Memory, Visual Memory, and Auditory Memory. Exercises are customizable to meet individual patient needs, facilitating personalized cognitive training.~User Experience: Each session comprises brief, self-administered exercises, with the order and difficulty adjusted by clinicians.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: video games
Description: Patients in the control group will use video games with no prominent cognitive involvement no prominent cognitive involvement
Study: NCT06415656

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: TempTraq
Description: TempTraq (Blue Spark Technologies, Westlake, OH) is an FDA 510K cleared wearable, wireless temperature monitoring patch designed to continuously monitor and track body temperature.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: VitalTraq
Description: VitalTraq (Blue Spark Technologies, Westlake, OH) is an experimental and novel multi-vital sign monitoring platform that allows for interval measurements of heart rate, heart rate variability, and blood pressure.