TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06174532

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Traditional Medthod
Description: Before surgery, the patient's lower jawbone tumor is replicated using a 3D-printed original model without adjustments. Then, the model undergoes manual modification by drilling and adjusting the jawbone model at the tumor site using drills and manual instruments. Subsequently, the reconstructed model is formed preoperatively based on this modified model. During surgery, the patient isn't guided by surgical guides, and the incision lines are relatively dependent on the surgeon. Additionally, while fixing the remaining bone after the sectioning, the surgeon uses pre-bent fixation plates made earlier to assist in stabilizing the bone.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Virtual surgical planning
Description: Before surgery, the patient's lower jawbone is 3D-printed, designed to remove the tumor mass, and create a suitable margin for reconstructive plate bending. Subsequently, the reconstruction plate is pre-bent preoperatively based on this model. During surgery, the patient is guided by specific surgical guiding tools: cutting guides. Additionally, while fixing the remaining bone after sectioning, the surgeon is assisted by bone fixation instruments to stabilize the alignment of the two bone fragments according to anatomical structure and then proceeds to use pre-bent reconstruction plates to secure the bone.
Study: NCT05450549

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Single doses
Study: NCT06051292

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fast method
Description: Fast decremental catheter volume titration will be applied and optimal filling volume will be determined according to the measurements

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional method
Description: Conventional catheter volume titration will be applied and optimal filling volume will be determined according to the measurements
Study: NCT06450171

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: GRAIL Galleri Test
Description: A multi-cancer early detection (MCED) blood test.
Study: NCT04712838

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR0302
Description: Group A subjects were given oral F1 、F2 and F3 version SHR0302

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR0302
Description: Group B subjects were given oral F1 、F3 and F2 version SHR0302

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR0302
Description: Group C subjects were given oral F2 、F1 and F3 version SHR0302

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR0302
Description: Group D subjects were given oral F2 、F3 and F1 version SHR0302

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR0302
Description: Group E subjects were given oral F3 、F1 and F2 version SHR0302

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SHR0302
Description: Group F subjects were given oral F3 、F2 and F1 version SHR0302
Study: NCT05423873

Intervention type: OTHER
Group type: OTHER
Intervention: Gentle Cleansing Lotion, Revision Skincare
Description: Gentle cleansing lotion to be used by study participants twice daily
Study: NCT04809714

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Blood Flow Restriction with Delfi Tourniquet System Cuff
Description: Postoperative rehabilitation will occur up to twice a day for 5 days a week for 2 weeks using a Delfi tourniquet system blood pressure cuff with a limb occlusion pressure (LOP) of 60-100%. For each physical therapy session, participants will undergo therapy following a standardized protocol of 3-5 difference exercises each with 4 sets total in addition to NMES.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Routine Post-operative Physical Therapy
Description: The control group with undergo a post-op therapy protocol that mirrors that of the intervention group except that they will use a Delfi tourniquet system blood pressure cuff with a limb occlusion pressure (LOP) of only 10%. Participants will use a neuromuscular electrical stimulation device operating at a sub-therapeutic level.
Study: NCT05535920

Intervention type: DRUG
Group type: OTHER
Intervention: LOKELMA 5 GM Powder for Oral Suspension
Description: Patients will use Lokelma supplementation on off-dialysis days (4 days/week) while receiving hemodialysis with 3.0 K+/2.5 Ca++ mEq dialysate bath. The individual starting dose will be 5.0 grams, and may be titrated weekly in 5.0 gram increments up to 15.0 grams to maintain K+ between 4.0 and 5.5 mEq/L.

Intervention type: DRUG
Group type: OTHER
Intervention: LOKELMA 5 GM Powder for Oral Suspension
Description: Patients will use Lokelma supplementation on off-dialysis days (4 days/week) while receiving hemodialysis with 3.0 K+/2.5 Ca++ mEq dialysate bath. The individual starting dose will be 5.0 grams, and may be titrated weekly in 5.0 gram increments up to 15.0 grams to maintain K+ between 4.0 and 5.5 mEq/L.
Study: NCT06144398

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Single Use Bronchoscope
Description: The interventional procedure is performed with a single use bronchoscope.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Standard Bronchoscope
Description: The interventional procedure is performed with a standard bronchoscope.
Study: NCT05532163

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Natalizumab
Description: Administered as specified in the treatment arm
Study: NCT06291727

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Mepivacaine
Description: Patients will be administered a standard dose of mepivacaine 1.5% (4.5ml, 67.5mg) for total knee arthroplasty prior to surgery

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bupivacaine
Description: Patients will be administered a standard dose of 0.75% hyperbaric bupivacaine (1.4ml, 10.5mg) for total knee arthroplasty prior to surgery
Study: NCT04559139

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cisplatin
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Given IV

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Gemcitabine Hydrochloride
Description: Given IV

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemcitabine Hydrochloride
Description: Given IV

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Lymphadenectomy
Description: Undergo portal lymphadenectomy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lymphadenectomy
Description: Undergo portal lymphadenectomy

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Partial Hepatectomy
Description: Undergo partial hepatectomy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Partial Hepatectomy
Description: Undergo partial hepatectomy
Study: NCT05591768

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Monopolar radiofrequency
Description: In monopolar group : . Inferomedial, superomedial, and superolateral GN branches of the patients were identified with ultrasonography, and a 22 Gauge, 10 cm radiofrequency (RF) cannula with a 10 mm active tip was advanced to the targeted nerves under fluoroscopy guidance. The location of the RF cannula was visualized by anteriorposterior and lateral images. Sensory stimulation was applied at 50 Hz to determine the nerve position. Since the sensory stimulation threshold must be \< 0.6 V, nerve position was tested with the absence of fasciculation in the relevant area of the lower extremity upon 2.0 V stimulation at 2 Hz.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bipolar radiofrequency
Description: a similar technique will be used to insert the canula, except that, instead of one cannula two cannulae (approximately 10 mm apart) apart) will be inserted and no manipulation of cannulae was done to stimulate the target nerve as done in MRFA Target areas were similar to monopolar technique Each nerve will be ablated for 90 s in both the groups. All procedures were done by one pain physician who had more then 10 years' experience of radiofrequency procedures.
Study: NCT05853939

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive TMS targeted by neuronavigation to left lower visual field of primary visual cortex. Randomized to 10 Hz or 1 Hz on different treatment days. Stimulation at 110% of phosphene threshold, or 110% resting motor threshold if phosphenes not detectable. 1 Hz: 1000 pulses total over 1000 seconds. 10 Hz: 1000 pulses over 10 10 second pulse trains, with 50 second intertrain intervals

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive TMS targeted by neuronavigation to left lower visual field of primary visual cortex. Randomized to 10 Hz or 1 Hz on different treatment days. Stimulation at 110% of phosphene threshold, or 110% resting motor threshold if phosphenes not detectable. 1 Hz: 1000 pulses total over 1000 seconds. 10 Hz: 1000 pulses over 10 10 second pulse trains, with 50 second intertrain intervals

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive TMS targeted by neuronavigation to left lower visual field of primary visual cortex. Randomized to 10 Hz or 1 Hz on different treatment days. Stimulation at 110% of phosphene threshold, or 110% resting motor threshold if phosphenes not detectable. 1 Hz: 1000 pulses total over 1000 seconds. 10 Hz: 1000 pulses over 10 10 second pulse trains, with 50 second intertrain intervals

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive TMS targeted by neuronavigation to left lower visual field of primary visual cortex. Randomized to 10 Hz or 1 Hz on different treatment days. Stimulation at 110% of phosphene threshold, or 110% resting motor threshold if phosphenes not detectable. 1 Hz: 1000 pulses total over 1000 seconds. 10 Hz: 1000 pulses over 10 10 second pulse trains, with 50 second intertrain intervals

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive TMS targeted by neuronavigation to left lower visual field of primary visual cortex. Randomized to 10 Hz or 1 Hz on different treatment days. Stimulation at 110% of phosphene threshold, or 110% resting motor threshold if phosphenes not detectable. 1 Hz: 1000 pulses total over 1000 seconds. 10 Hz: 1000 pulses over 10 10 second pulse trains, with 50 second intertrain intervals

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: repetitive transcranial magnetic stimulation
Description: Repetitive TMS targeted by neuronavigation to left lower visual field of primary visual cortex. Randomized to 10 Hz or 1 Hz on different treatment days. Stimulation at 110% of phosphene threshold, or 110% resting motor threshold if phosphenes not detectable. 1 Hz: 1000 pulses total over 1000 seconds. 10 Hz: 1000 pulses over 10 10 second pulse trains, with 50 second intertrain intervals
Study: NCT06326229

Intervention type: OTHER
Intervention: ICF entities assessment
Description: A visual analog scale will be used by the participants to evaluate the relevance of the ICF entities in relation to their musculoskeletal condition. The scale will range from 0 (no problem) to 100 (complete problem).
Study: NCT06321744

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: adapted physical activity program (APA Program)
Description: Content of the APA program:~* Strengthening of the lower limbs: Exercises alternating different regimes of muscular contractions (eccentric, concentric and isometric), with the use of elastics, balls or even body weight. These exercises will mainly work the quadriceps and hamstrings.~* Upper limb strengthening: Exercises focused on eccentric and concentric contraction regimes, in a global movement approach (as opposed to a segmental approach), with the use of elastics, dumbbells, weighted balls, etc. These exercises will work the muscles of the biceps, triceps, pectorals, deltoids and lats.~* Walking: In the room and/or in the corridor, with technical assistance (cane/walker, etc.) or human work~* Balance and proprioception: Balance work in a bi- and uni-pedal situation, statically and dynamically (eyes open and closed) will be offered with the use of proprioception boards and/or mats combining if possible work in dual task.
Study: NCT06662994

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aflibercept 8 mg (VEGF Trap-Eye, BAY86-5321)
Description: Identify patients that have had a previous vitrectomy and have DME that requires anti-VEGF therapy. Then using a treat-extend-stop protocol6,7 that I previously published, treat patients with DME using high dose aflibercept, until the fluid has resolved and then extend the time interval in between treatments for those patients, while maintaining a fluid-free macula.
Study: NCT06611605

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Storytelling with metaphor toys
Description: There is evidence of the effectiveness of various methods such as using different types of balls as tactile stimulation and active distraction methods during the management of pain, anxiety, and fear, watching cartoons, using virtual reality (VR) as a method of distracting attention, and using virtual reality hypnosis (VRH). However, no scientific study has been found on storytelling with a metaphoric toy during venous blood collection.~Before the children in the intervention group start the blood collection process, the story will be told to the child by the researcher in the waiting room of Akdeniz University Hospital Blood Collection Unit. The child and the parent will be together during the story telling. Expert opinions were received from five academics who completed their doctorate in Child Health and Disease Nursing for the content of the story.
Study: NCT06586021

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Aortoseal Endostapling System
Description: Aortoseal Endostapling System
Study: NCT06672393

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HS-10374 6mg tablets
Description: Specified dose of HS-10374 tablets administered orally QD on specified days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: HS-10374 6mg tablets
Description: Specified dose of HS-10374 tablets administered orally QD on specified days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: HS-10374-matched placebo tablets
Description: Specified dose of HS-10374-matched placebo tablets administered orally QD on specified days
Study: NCT06672965

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: anti-stress supplement
Description: The anti-stress supplement was developed to provide relief from anxiety and depression levels.Subjects were given 60 capsules of calming supplement (30-day supply) and instructed to take two capsules each day orally with water.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Subjects were given 60 capsules of placebo (30-day supply) and instructed to take two capsules each day orally with water.
Study: NCT06671886

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: E-trigger
Description: The NCCP Intervention is multicomponent. First, the investigators will apply the e-trigger and calculate FIB-4, and second, will educate and train PACT personnel on how to deal with trigger positive patients as well as make treatment recommendations within an inter-professional team. The e-trigger will be generated every 3 months. The effectiveness of the trigger will be assessed using the outcomes previously mentioned.
Study: NCT06671041

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Preservative Free eye drop
Description: Participants were required to use a lubricating eye drop
Study: NCT06671470

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: YZJ-1139 tablets
Description: Oral dose 20 mg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ticagrelor Tablets
Description: Oral dose 90 mg twice daily
Study: NCT06672055

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VXA-CoV2-3.1
Description: Tablets for oral use.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: COMIRNATY®
Description: Intramuscular (IM) injection.
Study: NCT06672419

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: AI-Guided Exercise and Pain Neuroscience Education
Description: This intervention consists of a 12-week tele-rehabilitation program that uses artificial intelligence (AI) and computer vision technology to guide personalized exercise sessions. Participants will complete three exercise sessions per week, which are monitored in real time by AI to ensure proper form and progression. Additionally, participants will attend weekly educational sessions focused on pain neuroscience to improve their understanding of chronic pain mechanisms and develop better pain management strategies. The intervention is delivered remotely via a digital platform and is overseen by a trained therapist who provides real-time feedback and adjusts the program as needed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Usual Care for Fibromyalgia
Description: Participants in this arm will receive the standard care for fibromyalgia, which includes pharmacological treatments and general management recommendations.~Drug: Pain Relievers~Description: Pain relievers, such as paracetamol and tramadol, are included in the standard care for fibromyalgia to manage pain levels. Drug: Antidepressants~Description: Antidepressants, such as amitriptyline and duloxetine, are prescribed to improve mood and reduce pain sensitivity as part of usual fibromyalgia care. Drug: Anticonvulsants~Description: Anticonvulsants, such as pregabalin and gabapentin, are used in standard care to manage pain and enhance sleep quality. Other: General Physical Activity and Disease Education~Description: Participants receive general recommendations on physical activity and disease management, consistent with clinical guidelines for fibromyalgia treatment.
Study: NCT06672107

Intervention type: BEHAVIORAL
Intervention: Active Driver Training Intervention
Description: simulated driver training focusing on practice of 4 specific driving skills including lane positioning, speed management, collision avoidance, and dashboard attention

Intervention type: BEHAVIORAL
Intervention: Active Driver Training Intervention
Description: simulated driver training focusing on practice of 4 specific driving skills including lane positioning, speed management, collision avoidance, and dashboard attention

Intervention type: BEHAVIORAL
Intervention: Control Intervention
Description: pre-scripted familiarization with driving simulator controls in the absence of any complex driving scenarios, decision making requirements, or feedback pertaining to driving skills

Intervention type: BEHAVIORAL
Intervention: Control Intervention
Description: pre-scripted familiarization with driving simulator controls in the absence of any complex driving scenarios, decision making requirements, or feedback pertaining to driving skills
Study: NCT06671340

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dorzagliatin
Description: chronic treatment with dorzagliatin for 4 weeks (50mg twice daily or 75mg twice daily, oral)
Study: NCT06671925

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Strengthening COnnections to Overcome Pain (SCOOP)
Description: Each week for 7 weeks, SCOOP intervention group participants will watch a brief video on the study website teaching a pain management or social connectedness skill and have a session with a community health worker, where they will receive support with behavioral goal-setting related to pain management and/or social connections. Participants will be screened for unmet social needs and connected to appropriate resources.
Study: NCT06692595

Intervention type: DIAGNOSTIC_TEST
Intervention: digital PCR
Description: digital PCR quantification of subgingival plaque samples

Intervention type: DIAGNOSTIC_TEST
Intervention: digital PCR
Description: digital PCR quantification of subgingival plaque samples
Study: NCT06693596

Intervention type: DIAGNOSTIC_TEST
Intervention: Group 2: Conservative management (follow-up)
Description: A standardised transabdominal examination is performed, including color or power Doppler examination. Transvaginal ultrasonography can be performed in sexually active adolescents with consent. Transrectal examination is also acceptable for younger patients who are not sexually active. All the variables required for the Simple Rules, simple descriptors and ADNEX model are assessed.~Before entering ultrasound information about the tumour and getting model results, the ultrasound examiner' s diagnosis (benign, borderline, malignant; specific diagnosis) based on subjective assessment is recorded. Results based on Simple Rules, simple descriptors and ADNEX model are documented as well.~If the adnexal mass is seen and if the decision is to manage the adnexal mass conservatively, the patient will be re-scanned at 6 weeks (maximal range 6-8 weeks), 3 months (+/- 2 weeks) and 12 months (maximal range 10-14 months)

Intervention type: PROCEDURE
Intervention: Group 1: Surgical management
Description: A standardised transabdominal examination is performed, including color or power Doppler examination. Transvaginal ultrasonography can be performed in sexually active adolescents with consent. Transrectal examination is also acceptable for younger patients who are not sexually active. All the variables required for the Simple Rules, simple descriptors and ADNEX model are assessed.~Before entering ultrasound information about the tumour and getting model results, the ultrasound examiner' s diagnosis (benign, borderline, malignant; specific diagnosis) based on subjective assessment is recorded. Results based on Simple Rules, simple descriptors and ADNEX model are documented as well.~If the patient requires surgery, no further ultrasound scans will be required.
Study: NCT06693856

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: High-Dose Methylprednisolone
Description: Methylprednisolone 500mg, administered intravenously once daily for 3 consecutive days, repeated every 4 weeks for a total of 24 weeks, followed by a follow-up period.
Study: NCT06044623

Intervention type: DRUG
Group type: OTHER
Intervention: CDK 4/6 inhibitors
Description: Either Palbociclib, Ribociclib or Abemaciclib
Study: NCT05278403

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual reality and video games
Description: Use of a software in stroke patients' rehabilitation.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Neurological physiotherapy
Description: Application of conventional physical therapy techniques.