Study: NCT05173077

Intervention type: PROCEDURE
Intervention: Identification of specific VOCs in CRC tissue surgery material
Description: Paired tissue samples will be taken during surgery for CRC. Tissue material from the same patient will be obtained from the cancerous tissue as well as from normal resected material without malignant infiltration. Minimum of 100 mg of each tissue per sample will be obtained. To compare the emission of VOCs in the CRC tissue surgery material to the emissions from normal tissue by GC-MS in a reasonable number of cancer cases.

Intervention type: OTHER
Intervention: Secondary validation study in general CRC screening settings
Description: Altogether at least 1000 individuals relatively healthy 40-64 years old population-based collected individuals will get recruited. Breath samples will be collected by asking the study subjects to breath into hybrid breath analyser.~To exclude significant colorectal lesions, laboratory-based FIT testing will be offered to the population cohort group for faecal occult blood in faeces. Serum and plasma samples will also be obtained to have them available if additional testing will be required. Individuals with a FIT test value over the cut-off value (\>10 microg/g faeces) will be invited to colonoscopy. The data analysis procedures and classification models will be tested in this general population and cross-checked against FIT and colonoscopy results.

Intervention type: DEVICE
Intervention: Breath sampling for VOC detection
Description: Breath sampling will be performed by using a hybrid sensor device and or GC-MS analysis (by collecting breath samples in adsorbent tubes). Strict requirements for subjects will be imposed prior to the breath sampling to standardise the breath sampling and to limit the influence of confounding factors.

Intervention type: DEVICE
Intervention: Breath sampling for VOC detection
Description: Breath sampling will be performed by using a hybrid sensor device and or GC-MS analysis (by collecting breath samples in adsorbent tubes). Strict requirements for subjects will be imposed prior to the breath sampling to standardise the breath sampling and to limit the influence of confounding factors.

Intervention type: DEVICE
Intervention: Breath sampling for VOC detection
Description: Breath sampling will be performed by using a hybrid sensor device and or GC-MS analysis (by collecting breath samples in adsorbent tubes). Strict requirements for subjects will be imposed prior to the breath sampling to standardise the breath sampling and to limit the influence of confounding factors.

Intervention type: OTHER
Intervention: Blood sample collection
Description: Serum, plasma sampling for group description and stratification.

Intervention type: OTHER
Intervention: Blood sample collection
Description: Serum, plasma sampling for group description and stratification.

Intervention type: OTHER
Intervention: Blood sample collection
Description: Serum, plasma sampling for group description and stratification.

Intervention type: OTHER
Intervention: Blood sample collection
Description: Serum, plasma sampling for group description and stratification.

Intervention type: OTHER
Intervention: Blood sample collection
Description: Serum, plasma sampling for group description and stratification.

Intervention type: DIAGNOSTIC_TEST
Intervention: Microbiota testing
Description: Faecal samples for microbiota testing.

Intervention type: DIAGNOSTIC_TEST
Intervention: Microbiota testing
Description: Faecal samples for microbiota testing.

Intervention type: DIAGNOSTIC_TEST
Intervention: Microbiota testing
Description: Faecal samples for microbiota testing.

Intervention type: DIAGNOSTIC_TEST
Intervention: Microbiota testing
Description: Faecal samples for microbiota testing.

Intervention type: DIAGNOSTIC_TEST
Intervention: Microbiota testing
Description: Faecal samples for microbiota testing.

Intervention type: DIAGNOSTIC_TEST
Intervention: Colonoscopy
Description: Colonoscopy will be used only according to the clinical indications.

Intervention type: DIAGNOSTIC_TEST
Intervention: Colonoscopy
Description: Colonoscopy will be used only according to the clinical indications.

Intervention type: DIAGNOSTIC_TEST
Intervention: Colonoscopy
Description: Colonoscopy will be used only according to the clinical indications.