TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06794086

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Stereotactic body radiation therapy
Description: Stereotactic body radiation therapy (SBRT) is a highly precise form of external beam radiation therapy used to treat tumors in various parts of the body. Enrolled patients will initiate SBRT treatment within 2 weeks after the first course of chemotherapy. Intensity-modulated radiation therapy (IMRT) will be used, with the gross tumor volume (GTV) receiving a dose of 8-12 Gy in 5 fractions, resulting in a total dose of 40-60 Gy. The biologically effective dose (BED) is equivalent to 72-132 Gy. The treatment will be administered from Monday to Friday.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PD-1 Monoclonal Antibody
Description: PD-1 monoclonal antibody is a type of immunotherapy drug designed to treat various cancers by targeting the programmed death receptor-1 (PD-1) pathway.The PD-1 monoclonal antibody used in this study is sintilimab at a dose of 200 mg, administered via intravenous infusion on Day 1. Participants will be considered eligible only if they have completed four or more cycles of PD-1 monoclonal antibody treatment both before and after SBRT.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chemotherapy
Description: Chemotherapy regimens based on fluorouracil (5-FU), such as CAPOX with a 3-week cycle or mFOLFOX6/FOLFIRI/FOLFOXIRI with a 2-week cycle, may be combined with targeted therapy. During chemotherapy or chemoradiotherapy, optimal supportive care will be provided.
Study: NCT06793358

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: fentanyl and Remimazolam
Description: This is the first dental study that will combine these two sedation drugs
Study: NCT06795269

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cryotherapy Compression Machine
Description: The Cryo Pro is a simple to use cold compression therapy product that requires only ice, water and power. It's unique design is convenient to use, provides pain relief and reduces swelling and inflammation, making recovery faster.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conservative treatment
Description: Strength and stretch exercises for hip and knee large groups of muscles.
Study: NCT06793969

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Swartz sheath with Angioplasty Guidewire-Assisted Technique for PFO tunnel passage
Description: The angioplasty guidewire is advanced into the left atrium and left superior pulmonary vein (LSPV). The Swartz sheath is then delivered to the left atrium along the 0.014 guidewire through the PFO. Next, the Runthrough guidewire is changed to a 0.035 J-tipped guidewire, which is advanced into the LSPV. Finally, the delivery sheath for the PFO closure device is introduced to the left atrium along the guidewire, and all other toolkits are withdrawn.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Conventional technique to pass the PFO tunnel
Description: In the conventional group, the PFO closure procedure is performed with a multi-functional catheter and guided by intraprocedural fluoroscopy and ICE
Study: NCT04995497

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Intravenous Administration of Lidocaine Post Cardiac Surgery
Description: Lidocaine will be administered via intravenously. Initial dose will be at 2 mg/kg ideal body weight followed by dosing at 2 mg/kg/hr for 48 hours

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Administration of Lidocaine Post Cardiac Surgery via ESP Catheter
Description: Lidocaine will be administered via ESP catheter. Initial dose will be at 2 mg/kg ideal body weight split between two catheters followed by dosing at 2 mg/kg/hr for 48 hours
Study: NCT06793319

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: educational app
Description: State Anxiety Inventory was filled out before the training. Atrial Fibrillation training was provided. After the training, the Situationality Anxiety Inventory was filled out again. It was aimed to evaluate the effect of education on anxiety.
Study: NCT06795906

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AZD8630
Description: AZD8630 will be administered via dry powder inhalation (DPI).

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will be administered via DPI.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Saphira device
Description: AZD8630 or placebo will be administered to participants via Saphira device.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Saphira device
Description: AZD8630 or placebo will be administered to participants via Saphira device.
Study: NCT06795490

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online program
Description: Families in Balance Online is a 6-week online program that includes 6 weekly group discussions and 3 individual support sessions, all held over Zoom. Program activities will focus on improving parent and child self-regulation as a means to encourage healthy family mealtime, sleep, and screentime routines. Participants will engage in in person and online data collection activities to understand whether the program is impactful.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Control Condition
Description: Families in Balance is an asynchronous program in which participants will be sent materials weekly over 6 weeks to encourage healthy family mealtime, sleep, and screentime routines. Participants will engage in in person and online data collection activities to understand whether the program is impactful.
Study: NCT06795542

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: lumbosacral transforaminal epidural injection at the level of L4-5, L5-S1, or S1 neural foramina
Description: The most widely used injection therapy is epidural injection of steroids, by either the interlaminar route or the caudal route. More contentious are transforaminal injections of steroids. These involve the injection of steroids directly and accurately onto the affected spinal nerve, under radiologic guidance. Meanwhile, transforaminal injection of steroids has been shown to be more effective than interlaminar injection of steroids
Study: NCT06795984

Intervention type: OTHER
Intervention: Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes
Description: The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts.

Intervention type: OTHER
Intervention: Establishing the correlation between KIR AA and KIR non-AA and CD56 endometrial cells and IVF succes
Description: The analysis aimed to compare CD56 levels between patients with the KIR AA genotype and those without. A multiple linear regression model was used to determine the predictive value of CD56+ levels, KIR genotype, and age on the number of blastocysts.
Study: NCT06796803

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: camrelizumab combined with apatinib and HAIC
Description: systemic therapy combined with locoregional theraphy as conversion therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: camerlizumab+apatinib
Description: systemic therapy
Study: NCT06793800

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Transcutaneous Auricular Vagus Nerve Stimulation
Description: TAVSS is an application system that uses an electrical transcutaneous stimulation device placed on the concha or tragus of the ear. Functional Magnetic Resonance Imaging studies have shown that stimulation of these areas activates the ipsilateral nucleus tractus solitarius (NTS) via vagal projections to the brainstem and forebrain. Unlike cervical vagus nerve stimulation, TAVSS utilizes a physiological pathway to activate the NTS and the dorsal motor nucleus, which subsequently sends impulses bilaterally to the heart surface via efferent cervical vagus nerves. Therefore, this technique eliminates the possibility of directly and asymmetrically stimulating cardiac motor efferent fibers, which could lead to adverse cardiac events. TAVSS combines advantageous qualities such as being non-invasive, cost-effective, convenient, and efficient.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcutaneous Auricular Vagus Nerve Stimulation
Description: TAVSS is an application system that uses an electrical transcutaneous stimulation device placed on the concha or tragus of the ear. Functional Magnetic Resonance Imaging studies have shown that stimulation of these areas activates the ipsilateral nucleus tractus solitarius (NTS) via vagal projections to the brainstem and forebrain. Unlike cervical vagus nerve stimulation, TAVSS utilizes a physiological pathway to activate the NTS and the dorsal motor nucleus, which subsequently sends impulses bilaterally to the heart surface via efferent cervical vagus nerves. Therefore, this technique eliminates the possibility of directly and asymmetrically stimulating cardiac motor efferent fibers, which could lead to adverse cardiac events. TAVSS combines advantageous qualities such as being non-invasive, cost-effective, convenient, and efficient.
Study: NCT06795399

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: OPC-131461
Description: OPC-131461 will be administered as oral tablets.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: OPC-131461
Description: OPC-131461 will be administered as oral tablets.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: OPC-131461 matched placebo will be administered as oral tablets.
Study: NCT06796270

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Hypofractionated radiotherapy
Description: The patients with nasopharyngeal carcinoma were given the dose of large segmentation radiotherapy, 2.64Gy/ time, 5 times/week, a total of 25 times, a total of 66Gy/5 weeks.
Study: NCT06796842

Intervention type: OTHER
Group type: OTHER
Intervention: Ballistic Exercises
Description: Ballistic training program was set for 6 weeks. Each week consisting of 5 exercises with sets of 3 and repetitions of 10,15 and 20 times, recovery time and training intensity differed each week.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Plyometric exercises
Description: Plyometric training program was set for 6 weeks. With four exercises in 1st week. Five in 2nd and 3rd weeks, six exercises in 4th and seven exercises in last two weeks. Each exercise consisted of 3 sets with 10, 15 and 20 repetitions in each. Recovery time and training intensity differed each week.
Study: NCT05888727

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Seated Physical activity INtervention for persons with MS, SPIN program- Intervention Condition
Description: The proposed exercise training program is based on Social Cognitive Theory (SCT) for promoting aerobic and strength training in wheelchair users with MS. The 16-week program includes one-on-one video chats with a behavioral coach and various tracks for progressive increases in both strength and aerobic training. The proposed strength training includes 15 exercises with step-by-step instructions using resistance bands and/or wrist weights that were adapted for seated body-position that can be executed in a wheelchair. The proposed aerobic training is arm cycle ergometry; this is a low-cost and modifiable option that fits the needs of both power and manual wheelchair users. Other proposed equipment includes a comprehensive Training Manual, fitness tracker for use during exercise training sessions, and Rate of Perceived Exertion (RPE) scale for guiding individualized exercise intensity. The research team created 12 Newsletters that align with 12 proposed coaching calls.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: WEllness for Longevity Living with MS (WELL)- Control Condition
Description: The attention/contact wellness control condition will mirror the exercise training intervention condition, but focuses on implementing health behaviors other than physical activity (e.g., diet and emotional wellbeing). This program is an adapted version of the WellMS program from Prof. Motl's Phase III clinical trial (NCT03490240). The program is based on SCT principles of behavior change and integrates wellness resources from the National MS Society (NMSS). The research team has created 12 Newsletters that will be delivered on the same chat schedule as the exercise training intervention. All coaching chats and newsletters will occur with the same frequency as in the exercise training intervention condition. Participants will be provided with a participant manual, logbook, and calendar. Participants will work with their behavioral coach on goal setting specific to wellness behaviors.
Study: NCT06795347

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Online VIPP-SD
Description: The Video-feedback Intervention to promote Positive Parenting and Sensitive Discipline is delivered online in this study. VIPP-SD is a manualized parenting intervention. The online version consists of 12 individual sessions, where the first and hereafter every second session consists of video recordings of mother and child in pre-defined everyday situations. The recordings are reviewed and discussed with the mother/parents during subsequent video-feedback sessions, where positive sequences in the interaction are pointed out by the intervener and form the basis of a discussion of pre-defined themes regarding child signals, attachment, child development, limit setting and sensitive parenting. The 12 sessions are conducted within five months from randomization with weekly or bi-weekly intervals.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Care As Usual
Description: Care As Usual is defined as any kind of help and support the parents may receive related to the socio-emotional development and mental wellbeing of their child in the municipality or the mental health services.
Study: NCT06796244

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Croq'Santé nutrition education program
Description: The Croq'Santé program aims to develop food literacy in children aged 8 to 11 years. It is based on the creation or adaptation of a recipe chosen by the children. The program is designed to run over the course of one school year, with approximately ten sessions. These sessions are delivered in schools by teachers, following a 3-hour training course. Teachers receive an intervention kit that includes a guide for conducting the different sessions, food images, and a mascot, which children can accessorize as they complete sessions and challenges. The sessions are organized around four stages: discover, invent, cook, and taste. Challenges are to be completed at the end of each stage with the child's family. At the end of the program, children are invited to cook and taste their recipe in a dedicated environment.
Study: NCT05134779

Intervention type: PROCEDURE
Intervention: Live Biobank
Description: Tumor tissue will be collected from consented patients at sequential inflection points in the disease course: at the time of initial diagnosis, at the time of surgery and during recurrence or metastasis. In addition to this, 40ml of research bloods will also be collected at these key inflection points.
Study: NCT06793059

Intervention type: DEVICE
Group type: OTHER
Intervention: SHIELD
Description: Pipeline SHIELD device under study
Study: NCT06793670

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Landiolol
Description: Intravenous infusion of landiolol

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Intravenous infusion of saline solution of NaCl 0.9%
Study: NCT06793371

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CK-4021586 (150 mg, 300 mg, 450 mg, and 600 mg)
Description: CK-4021586 administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CK-4021586 (150 mg, 300 mg, 450 mg, and 600 mg)
Description: CK-4021586 administered orally

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: CK-4021586 (150 mg, 300 mg, 450 mg, and 600 mg)
Description: CK-4021586 administered orally

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo to match CK-4021586
Description: Placebo administered orally
Study: NCT06163950

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Fatigability assessment
Description: An isometric dynamometer will be used to assess fatigability development during a task to failure. Throughout the task, which consists of blocks of 3 minutes, neuromuscular assessments will take place to determine the evolution of fatigability and its peripheral and central determinants.
Study: NCT05987605

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 1A46 Drug Substance
Description: Cycle 1 which will consist of an initial dose given on C1D1 and an intermediate dose given on C1D8, followed by a maintenance dose beginning on C1D15 and continuing while the patient is treated at that dose level
Study: NCT06793371

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo to match CK-4021586
Description: Placebo administered orally

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo to match CK-4021586
Description: Placebo administered orally
Study: NCT06787677

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PRF
Description: After the puncture needle reached the sphenopalatine ganglion (SPG), patients in the PRF group received PRF treatment in automatic mode for 360 s, at a maximum of 42°C, pulse frequency of 2 Hz, and pulse width of 20 ms.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: NB
Description: After the puncture needle reached the sphenopalatine ganglion (SPG), patients in the NB group received nerve block with a mixture of 40 mg of triamcinolone and 2 ml of 0.75% bupivacaine with 2 ml of normal saline and 1:100000 epinephrine.
Study: NCT04063501

Intervention type: OTHER
Intervention: Bronchoscopy
Description: The patient will then return within a week for a research bronchoscopy to sample the upper and lower airways

Intervention type: OTHER
Intervention: Research Procedures
Description: electrocardiogram, blood work (CBC, chemistry, coagulation profile and liver function tests, pregnancy test if applicable), X-ray and pulmonary function (spirometry) testing, and provide the patient with a stool collection kit.
Study: NCT06793085

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-6 (il-6) concentration in blood serum
Description: Measurement of fasting interleukin-6 (il-6) concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-6 (il-6) concentration in blood serum
Description: Measurement of fasting interleukin-6 (il-6) concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-6 (il-6) concentration in blood serum
Description: Measurement of fasting interleukin-6 (il-6) concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of fasting tumor necrosis factor α (TNF-α) concentration
Description: Measurement of fasting tumor necrosis factor α concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of fasting tumor necrosis factor α (TNF-α) concentration
Description: Measurement of fasting tumor necrosis factor α concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of fasting tumor necrosis factor α (TNF-α) concentration
Description: Measurement of fasting tumor necrosis factor α concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-18 (il-18) concentration
Description: Measurement of interleukin-18 (il-18) concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-18 (il-18) concentration
Description: Measurement of interleukin-18 (il-18) concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-18 (il-18) concentration
Description: Measurement of interleukin-18 (il-18) concentration in fasting venous blood serum

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-4 (il-4) concentration
Description: Measurement of interleukin-4 (il-4) concentration in fasting venous blood plasma

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-4 (il-4) concentration
Description: Measurement of interleukin-4 (il-4) concentration in fasting venous blood plasma

Intervention type: DIAGNOSTIC_TEST
Intervention: Measurement of interleukin-4 (il-4) concentration
Description: Measurement of interleukin-4 (il-4) concentration in fasting venous blood plasma
Study: NCT06795971

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous Positive Airway Pressure
Description: 1. Patients were placed at a 45-degree supine position, and noninvasive ventilation was delivered to the patient through a face mask connected to an ICU ventilator.~2. PEEP was started at 5 cm H2O with a FiO2 of 0.5 at initiation. PEEP and FiO2 were titrated to maintain SpO2 between 94 and 98%, remaining constant for at least 5 min.~3. CPAP was initiated with a first session of at least 4 h, the minimally required duration of noninvasive ventilation was 16 hours per day for at least 2 calendar days. Between noninvasive-ventilation sessions, patients received HFNO.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: High-flow nasal oxygen
Description: 1. Oxygen was passed through a heated humidifier (MR850, Fisher and Paykel Healthcare) and applied continuously through large-bore binasal prongs, with a gas flow rate of 50 liters per minute and an FiO2 of 0.5 at initiation. HFNO heating temperature was prespecified at 37°C.~2. FiO2 will be titrated to maintain SpO2 between 94 and 98%, remaining constant for at least 5 min.~3. HFNO was applied for at least 2 calendar days.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Non-invasive ventilation
Description: 1. Patients were placed at a 45-degree supine position, and noninvasive ventilation was also delivered to the patient through a face mask connected to an ICU ventilator. The mask most appropriate for the patient will be selected and adjusted to minimize leakage and pressure points.~2. The inspiratory positive airway pressure (pressure support plus PEEP) was initiated between 12 and 14 cm H2O, PEEP was started at 5 cm H2O with a FiO2 of 0.5 at initiation. FiO2 was titrated to maintain SpO2 between 94 and 98%, remaining constant for at least 5 min.~3. NIV was initiated with a first session of at least 4 h, the minimally required duration of noninvasive ventilation was 16 hours per day for at least 2 calendar days. Between noninvasive-ventilation sessions, patients received HFNO.