TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04799171

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Isometric Contraction Exercise - Young Adults (Age group 18-39)
Description: Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Isometric Contraction Exercise - Middle Age Adults (Age group 40-59)
Description: Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Isometric Contraction Exercise - Old Adults (Age group >60)
Description: Subjects will be asked to lie supine on MRI table with the 31P surface coil placed over the right vastus lateralis, and straps to immobilize the leg. At the start of the scan session, the investigators will instruct the participant on the isometric contraction exercise and coach the participant through a demonstration. The average flexion repetition time is on the order of 1.5 s for a 30 s duration at maximum kick intensity.
Study: NCT05155618

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: INTERVENTION GROUP
Description: Personalized advice to prevent side effect according to their health status will be provided by a dietitian and a physiotherapist.
Study: NCT04611958

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ERCP with Bupivacaine infusion
Description: Selective cannulation of the pancreatic duct with ERCP scope will be performed. Any contrast dye used will be carefully aspirated and the duct will be flushed with saline as necessary to clear all residual dye. The canula will be taken to the tail of the pancreatic duct, and gradually withdrawn with slow infusion of the bupivacaine solution. Liposomal bupivacaine (13.3 mg/ml of Exparel) will be injected into the main pancreatic duct for a total of 5-10 ml (depending on the length of the pancreatic duct).~Immediately after the procedure, the patient will be monitored for any evidence of acute pancreatitis (worsening abdominal pain, with amylase or lipase x3 upper limit of normal). The patient will be questioned daily after the procedure for common side effects of bupivacaine including nausea, fever, change in taste, dizziness, weakness, palpitations and loss of taste or any other new or unusual symptom.
Study: NCT04971239

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: topical methotrexate micoemulsion
Description: The selected microemulsion composition consists of 40% Jojoba oil, 45% Tween-80 and Span-85 at a ratio of 3:1 as surfactant and co surfactant, respectively and 15% water. The chosen concentration was based on preliminary studies conducted which delineated that these ratios provided the best skin deposition based on factorial skin modelling.The prepared microemulsions contains 0.1% methotrexate

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: topical methotrexate micoemulsion
Description: The selected microemulsion composition consists of 40% Jojoba oil, 45% Tween-80 and Span-85 at a ratio of 3:1 as surfactant and co surfactant, respectively and 15% water. The chosen concentration was based on preliminary studies conducted which delineated that these ratios provided the best skin deposition based on factorial skin modelling.The prepared microemulsions contains 0.1% methotrexate

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: topical methotrexate micoemulsion
Description: The selected microemulsion composition consists of 40% Jojoba oil, 45% Tween-80 and Span-85 at a ratio of 3:1 as surfactant and co surfactant, respectively and 15% water. The chosen concentration was based on preliminary studies conducted which delineated that these ratios provided the best skin deposition based on factorial skin modelling.The prepared microemulsions contains 0.1% methotrexate

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Excimer light
Description: the excimer laser will be done twice weekly for a total treatment course of 12 weeks.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Narrow band ultraviolet B
Description: the Narrow band ultraviolet B will be done twice weekly for a total treatment course of 12 weeks.
Study: NCT04861818

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Moderate-intensity aerobic exercise
Description: Eligible participants will come into the lab on day 1 and 3 at the same time of day (either morning at 7-10am or afternoon at 3-5pm). They will be then randomly assigned for a rest or an exercise session prior to the memory test. For the rest condition, they will be required to sit and relax while watching Planet Earth for 30 minutes on a cycle ergometer. During the exercise session, they will complete a moderate-intensity cardiovascular exercise for 20 minutes following a 5-min warm-up and followed by a 5-min cool-down on a cycle ergometer. They will start the memory test immediately after the rest/exercise session.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Moderate-intensity aerobic exercise
Description: Eligible participants will come into the lab on day 1 and 3 at the same time of day (either morning at 7-10am or afternoon at 3-5pm). They will be then randomly assigned for a rest or an exercise session prior to the memory test. For the rest condition, they will be required to sit and relax while watching Planet Earth for 30 minutes on a cycle ergometer. During the exercise session, they will complete a moderate-intensity cardiovascular exercise for 20 minutes following a 5-min warm-up and followed by a 5-min cool-down on a cycle ergometer. They will start the memory test immediately after the rest/exercise session.
Study: NCT05046990

Intervention type: DIAGNOSTIC_TEST
Intervention: Regular Arrangement of Collecting Venules
Description: This is a prospective, multicentre, international study without a control group.
Study: NCT03335072

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin
Description: Mass Drug Administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin
Description: Mass Drug Administration

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin
Description: Mass Drug Administration

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Azithromycin
Description: Mass Drug Administration
Study: NCT05129280

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RO7444973
Description: RO7444973 solution for infusion will be administered intravenously at a dose and per schedule as specified for the respective cohort.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RO7444973
Description: RO7444973 solution for infusion will be administered intravenously at a dose and per schedule as specified for the respective cohort.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RO7444973
Description: RO7444973 solution for infusion will be administered intravenously at a dose and per schedule as specified for the respective cohort.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tocilizumab
Description: Tocilizumab will be used as rescue therapy, in case of clinical presentation of cytokine release syndrome (CRS). Tocilizumab solution for infusion will be administered intravenously at 8 mg/kg for participants \>/= 30 kg or at 12 mg/kg for participants \< 30 kg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tocilizumab
Description: Tocilizumab will be used as rescue therapy, in case of clinical presentation of cytokine release syndrome (CRS). Tocilizumab solution for infusion will be administered intravenously at 8 mg/kg for participants \>/= 30 kg or at 12 mg/kg for participants \< 30 kg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tocilizumab
Description: Tocilizumab will be used as rescue therapy, in case of clinical presentation of cytokine release syndrome (CRS). Tocilizumab solution for infusion will be administered intravenously at 8 mg/kg for participants \>/= 30 kg or at 12 mg/kg for participants \< 30 kg.
Study: NCT03923452

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness-based Stress Reduction
Description: Mindfulness-based stress reduction is a manualized mindfulness training protocol that has been researched for over 20 years. The original protocol will be used, with the exception of the prescribed home practice duration (i.e. 30 mins of practice). Rather, the program will be modified to set up participants for success by providing them with instruction to build on their meditation practice, beginning with 8 minutes a day.
Study: NCT06381700

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: MySmile app
Description: The MySmile app contains several features:~A) Knowledge Hub~1. Do You Know section: This section consists of seven (7) topics where users can learn about oral health knowledge.~2. Quiz time section: In this section, school children can play games and challenge themselves.~B) Track yourself Brushing diary Diet diary~C) Get help~1. Ask an expert~2. Find your dentist~3. Friendly reminders

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: This will receive the usual School Dental Service.~School Dental Service provide students who need dental treatment and will be called to be given treatment. Among the treatments given include:~* Dental filling~* Full mouth scaling~* Dental extraction~* Preventive treatment, such as topical fluoride application~All treatment is free of charge except for dentures, crown/bridge work and orthodontics. Treatment for school children is based on normative needs assessment as determined by the dentist. A child is defined as orally fit when all required treatment in the SDS has been completed and appropriate oral hygiene status is maintained.
Study: NCT05298371

Intervention type: BEHAVIORAL
Intervention: Corrected Sitting postures
Description: Change after being in Corrected Sitting postures

Intervention type: BEHAVIORAL
Intervention: Natural / relaxed sitting postures
Description: Change after being in relaxed sitting postures

Intervention type: BEHAVIORAL
Intervention: Corrected Standing posture
Description: Change after being in Corrected Standing posture

Intervention type: BEHAVIORAL
Intervention: Natural / relaxed standing postures
Description: Change after being in relaxed standing postures
Study: NCT06520371

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Percutaneous radiofrequency
Description: For the percutaneous radiofrequency treatment, a medium electrode size will be placed on either side of the knee: one skin electrode on the inside and one on the outside of the knee for 15 minutes.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Conventional radiofrequency
Description: For the conventional radiofrequency treatment, a 50 Hz sensory stimulation will be performed with a 10 cm, 22 gauge, 10 mm active tip radiofrequency cannula. After receiving the appropriate sensory and motor stimuli, a radiofrequency of 90°C will be applied for 90 s.
Study: NCT05762419

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etoposide; Oral, 50 Mg
Description: Subjects will receive focused ultrasound sonication followed by once daily oral etoposide (50mg/m\^2/dose). Oral etoposide will be taken every day for 21 days, followed by one week of rest. For the first cycle, etoposide will be administered immediately following confirming of the blood brain barrier opening through contrast magnetic resonance imaging (MRI) which will occur within 4 hours of the focused ultrasound procedure. For subsequent cycles, etoposide will be administered immediately following the focused ultrasound procedure. Subjects may continue for a maximum of 4 cycles.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Focused ultrasound with neuro-navigator-controlled sonication
Description: Focused ultrasound sonication will be performed a maximum of three times a week for two weeks with two weeks of rest.
Study: NCT06411639

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ianalumab
Description: ianalumab will be provided in a pre-filled Syringe (PFS) of 150 mg/1 mL for s.c. administration. Two injections of 1mL each will be administered monthly.
Study: NCT05438823

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Educational Programe
Description: IBK-EBP will be administered to parents in six sessions in six days. After six days of training, the mobile application will be used by parents for 8 weeks. The frequency of use of the mobile application will be left entirely to the needs of the parents and reminders will be made through the mobile application. In addition, the video used during the face-to-face training, progressive relaxation exercise videos and motivational sentences will also be included in the mobile application.
Study: NCT05206240

Intervention type: OTHER
Intervention: Radial extracorporeal shock wave therapy and conventional physical therapy
Description: The conventional physical therapy program will consist of verticalization strategies, range of motion exercises, muscle stretching and strengthening exercises, stance and balance training, core stability exercises, gait training, functional training, cryotherapy or local heat for 1h/day, 5 days/week for 2 weeks.~Regarding the rESWT delivery, 2000 shots will be applied on the triceps surae myotendinous junction with a frequency of 10 Hz and an energy density of 60 mJ, 7 min/session, 1 session/week for 2 weeks.
Study: NCT05998070

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Training group
Description: Hip strengthening exercises will be performed 3 times a week for 6 weeks in the training group. 3 exercises consisting of 2 sets and 10 repetitions will be performed every week. A rest interval will be given between sets.
Study: NCT05598944

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The MBSR program
Description: The MBSR program is a group-based therapy which teaches mindfulness skills through a range of formal and informal mindfulness practices. Created by Kabat-Zinn (1982), in the current study it is taught by an officially accredited instructor and is compliant with the guidelines established by Brown University and the University of Massachusetts, USA. It originally consists of 8 weekly classes, 2 hours each (18 hours direct instruction), together with a day of intensive practice.~The program is structured along the following topics: The Underpinnings of MBSR; The Perception of Reality; Power in Being Present; Understanding Stress: The Mind-Body Relation; Responding to Stress; Communication and Personal Relations; Daily Life Management; My Personal Plan: What lies ahead.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Más Presente, the UGRComp program
Description: Más Presente, the UGRComp program is based upon the European LifeComp framework (Sala, Punie, Garkov and Cabrera Giraldez 2020) and covers intra and interpersonal, emotional, cognitive and metacognitive aspects. Created at the University of Granada by an interdisciplinary group of experts, it focuses on three core elements (self-regulation, empathy and growth mindset) as they are the pre-requisites for developing all other elements across framework areas. It consists of 8 weekly classes, 2 hours each, together with a day of intensive practice.~The program is structured along the following topics: The Underpinnings of Más Presente; Awareness and Concentration: our Body; Managing our Emotional Laberynth; Walking with Directionality, Sense and Conscience; Empathy, Presence and Connection; Empathic Listening and Honest Expression: Non-violent communication; Growth Mindset, Creativity and Divergent Thinking; And Now what? The First Day of the Rest of My Life.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Neuro-muscular stimulation
Description: Subjects will receive weekly sessions with a combination of educational sessions and specific physical exercises to enhance physical wellbeing and prevent neuro-degeneration . After spotting the therapeutic targets for each subject, a 4-phase program will be designed for each subject aimed at improving lifestyle habits and general wellbeing.
Study: NCT06107842

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Gerofit exercise
Description: Individualized exercise prescription as well as a group exercise class based on physical function assessments offered 3x/week

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Health education
Description: Scheduled monthly in-person health education discussion sessions covering 12 different health topics not including a physical activity/exercise promotion session
Study: NCT04739553

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: His Pacing
Description: The patients will receive a pacemaker implant with a traditional right ventricular pacing lead and an additional His pacing lead in a basal high septal position at the level of the proximal electrical conduction system (His). An atrial lead is implanted if dual chamber pacing is needed. All leads are connected to a biventricular pacemaker with the His lead in the LV port.
Study: NCT05093595

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: SFC
Description: The lubricated SFC passed nasally into the oropharynx under the visual guidance of visual laryngoscope to ensure that the cuff had passed through the posterior choanae and reached the oropharynx. The guide wire is removed and the balloon inflated with 5 ml normal saline. The catheter is then pulled slightly until the balloon is fixed and concealed by the soft palate . The ETT is anchored to the SFC with a cable tie .
Study: NCT05798936

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Polidocanol
Description: Polidocanol is injected under complete aseptic conditions. Before the treatment the diameter and volume of each nodule is calculated. To prevent serious hemorrhage, vessels located along the approach route will be carefully evaluated by using Doppler US.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Alcohol
Description: Alcohol is injected under complete aseptic conditions. Before the treatment the diameter and volume of each nodule is calculated. To prevent serious hemorrhage, vessels located along the approach route will be carefully evaluated by using Doppler US.
Study: NCT05145322

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Composite with 90 degree cavosurface angle
Description: Lesion-specific cavity design with 90 degree cavosurface angle throughout the cavity margins will be prepared. The total etch method will be performed, i.e. with a 32% by weight phosphoric acid (3M Scotchbond™ Universal Etchant) on enamel and dentine for 15 seconds. The etchant will be rinsed away and an adhesive (3M Scotchbond™ Universal Adhesive) will be applied on dentine with a microbrush for 20 seconds. The adhesive will be light-cured for 10 sec with the Elipar S10 curing light (3M Oral Care). Subsequently the preparation will be restored with a bulkfill resin composite (3M Filtek™ One Bulk Fill Restorative) and cured for 20 seconds.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Composite with wide bevel
Description: Lesion-specific cavity design with wide bevel throughout the cavity margins will be prepared. The total etch method will be performed, i.e. with a 32% by weight phosphoric acid (3M Scotchbond™ Universal Etchant) on enamel and dentine for 15 seconds. The etchant will be rinsed away and an adhesive (3M Scotchbond™ Universal Adhesive) will be applied on dentine with a microbrush for 20 seconds. The adhesive will be light-cured for 10 sec with the Elipar S10 curing light (3M Oral Care). Subsequently the cavity will be restored in with a pre-warmed (using Bioclear Heatsync Kit) bulkfill resin composite (3M Filtek™ One Bulk Fill Restorative) and cured for 20 seconds.
Study: NCT06446596

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise supported by the digital physiotherapy and telerehabilitation software TRAK
Description: 8 week home therapeutic exercise program that includes flexibility and strength exercises scheduled through the software a digital physiotherapy and telerehabilitation. The program will be carried out with a frequency of 3 weekly sessions, preferably on alternate days. The program will be carried out with the support of the TRAK software (https://www.trakphysio.com/es/), which allows the exercises to be carried out in front of a camera that, with the help of an artificial intelligence system, offers feedback to the participant and allows you to keep a record of the sessions. As an addition to the home sessions, two face-to-face sessions will be held in the first and fifth weeks, respectively. The exercise program includes three levels of difficulty (easy, intermediate and difficult), with patients advancing to subsequent levels once each level is successfully overcome.
Study: NCT05622097

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 0.9% Saline warmed to 37 degrees Celsius
Description: 0.9% Saline warmed to 37 degrees Celsius

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: 0.9% Saline warmed to 24 degrees Celsius
Description: 0.9% Saline warmed to 24 degrees Celsius
Study: NCT06205550

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Flecainide
Description: Flecainide monotherapy
Study: NCT06446596

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard home-based exercise
Description: 8 week home therapeutic exercise program that includes flexibility and strength exercises scheduled through a dossier and an exercise diary. The program will be carried out with a frequency of 3 weekly sessions, preferably on alternate days. The program will be carried out with the support of an information dossier of the exercises to be performed and a monitoring diary in which everything related to the sessions carried out will be noted.. As an addition to the home sessions, two face-to-face sessions will be held in the first and fifth weeks, respectively. The exercise program includes three levels of difficulty (easy, intermediate and difficult), with patients advancing to subsequent levels once each level is successfully overcome.
Study: NCT06205550

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Flecainide + beta-blocker
Description: Flecainide + beta-blocker
Study: NCT05205850

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: RC118-ADC
Description: RC118 for injection is a novel antibody-drug conjugate, with a Claudin 18.2-targeting antibody and a microtube inhibitor
Study: NCT04916353

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: hypertonic dextrose water
Description: 20% hypertonic dextrose water injection for chronic shoulder pain

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Triamcinolone Acetonide.
Description: Triamcinolone Acetonide 40mg/1ml injection