TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06504199

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cytarabine
Description: The specific dose is determined by the investigator according to the actual situation of the patient.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CAR-T
Description: zanubrutinib in combination with lenalidomide was allowed for maintenance treatment in high-risk patients for 1 year and zanubrutinib for 2 years after recovery of hemogram 2 months after CAR-T. High-risk Patients with any of the following conditions: Mantle cell lymphoma International Prognostic Index (MIPI-c) high-risk, blastic/pleomorphic type, TP53 mutation/deletion, CDKN2A deletion, MYC amplification/translocation, or incomplete response at induction stage; Non-high-risk group: no high-risk features.
Study: NCT06388395

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Accuracy of full-arch surgical guides
Description: The accuracy of the surgical guides will be assessed by superimposing the pre and post-treatment CBCT scans.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Survival and complications of the prostheses
Description: Two different prostheses will be assessed (conventional and PEEK). All complications will be recorded for a period of 3 years

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Survival and complications of the implants
Description: The effect of the two different prostheses on implants will be assessed in terms of survival and success rates.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Conventional (metal-resin) implant-supported prosthesis
Description: Full-mouth implant-supported conventional prosthesis will be constructed and evaluated for up to 3 years.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PEEK implant-supported prosthesis
Description: Full-mouth implant-supported PEEK prosthesis will be constructed and evaluated for up to 3 years.
Study: NCT05522127

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Colonoscopy
Description: Colonoscopy

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Colonoscopy
Description: Colonoscopy

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Sedoanalgesia
Description: Ketamine, fentanil, midazolam, propofol

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Sedoanalgesia
Description: Ketamine, fentanil, midazolam, propofol
Study: NCT06124729

Intervention type: DRUG
Intervention: Bevacizumab Combined With PD-1 Monoclonal Antibody
Description: Bevacizumab Combined With PD-1 Monoclonal Antibody in Preoperative Neoadjuvant Therapy for MSS colorectal cancer with liver metastases
Study: NCT06577922

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Establishment of a simulation lab and provision of simulation based trainings
Description: In each hospital, the investigators will perform an initial need assessment to identify the existing skills labs' space, equipment and trained human resources. Then, maternal and neonatal health simulation labs will be established in each hospital. One simulation lab will have 5 rooms- one auditorium hall, one debrief room, two simulation rooms, and one high fidelity simulation room. Equipment and manikins required for practicing maternal and neonatal health related skills will be installed in the simulation lab, along with guidance/ checklists for skills practice. After completion of lab set-up, trainings will be provided to trainers/ MNH staff of each hospital on simulation based methodology, especially focusing on Essential Care for Labor and Birth (ECLB), Bleeding after Birth (BAB), and Helping Babies Breathe (HBB) modules. Similarly, the investigators will also provide training for simulation lab operation and maintenance.
Study: NCT05439967

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Augmented and Virtual Reality Gait and balanceTraining
Description: C-Mill VR+ device used for training. The training was carried out 3 days a week for 6 weeks, with each exercise session lasting approximately 1.5 hours, accompanied by a physiotherapist. Training started with conventional exercises, continued with C-Mill VR+ training, and ended with stretching and relaxation exercises. The patients in the intervention group were applied the exercises with the same principles with conventional training, except the exercises performed in standing and walking. Patients performed 10 exercises in AR and VR gait training for 4 minutes and resting the individuals by sitting for 1 minute between exercises.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Training
Description: Conventional training was applied to the patients in the control group. Conventional training was planned taking into account the following goals: increasing mobility by improving the impaired kinesthetic sensation; improving axial rotation, coordination, flexibility of soft tissues, mobility in and out of bed; increasing body image perception by improving upright and proper posture; and improving balance and gait. The training was applied 3 days a week for 6 weeks, with each exercise session lasting 40-50 minutes, accompanied by a physiotherapist. Each of the exercises was done in 2 sets of 10 repetitions. In gait training, each exercise was performed for 4 minutes.
Study: NCT05963815

Intervention type: OTHER
Intervention: Spine surgery
Description: Patients operated with laminectomy, microscopic discectomy, percutaneous transforaminal endoscopic discectomy, and spondylodesis.
Study: NCT05470608

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SL-1002
Description: SL-1002 injectable solution

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matching placebo injectable solution
Study: NCT06308068

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Diacerein 50 mg Capsule
Description: Diacerein 50 mg Capsule

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Diacerein 50 mg Capsule
Description: Diacerein 50 mg Capsule
Study: NCT05930730

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Comvigen (Bivalent, ChulaCov19 BNA159.2)
Description: single dose of COMVIGEN at 50 ug, as a booster dose, given at 3 months and above after receipt of a previous booster dose of any approved mRNA COVID-19 vaccine

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: BIVALENT Pfizer/BNT vaccine
Description: single dose of BIVALENT of Pfizer/BNT Bivalent vaccine at 30 ug, as a booster dose, given at 3 months and above after receipt of a previous booster dose of any approved mRNA COVID-19 vaccine
Study: NCT05684809

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Post Isometric relaxation Technique (PIR)
Description: In PIR intervention, the patients were requested to lie down in a supine position and their neck was in a lateral flexion to the opposite side so that the target upper Trapezius muscle fibers would be in a lengthened position. The therapist performed a moderate isometric contraction (approximately 75% of maximal) of upper Trapezius muscles, held it for 5 seconds, then relaxed for 3 seconds before moving the cervical spine into the new barrier. In each session, this technique was repeated for four times, on alternate days for three weeks.
Study: NCT05616858

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Complex exercise program
Description: Stretching exercise, aerobic exercise, strengthening and balancing exercise
Study: NCT05778396

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Active spinal manual therapy protocol
Description: The chiropractor will start by (1) placing one hand over L4-L5 or L5-S1 and then will apply a high-velocity, low-amplitude (HVLA) thrust with a therapeutic line of drive. Side-lying lumbar manipulation will be performed bilaterally, with the treating clinician choosing any suitable technique and with or without occurrence of the characteristic audible joint cavitation associated with spine manipulation. The chiropractor will then perform (2) prone lumbar mobilisation by placing the contact hand and applying downward pressure over L4-L5 or L5-S1 with the other hand guiding a manual flexion-distraction piece to apply therapeutic mobilization of the lumbar spine. The chiropractor will deliver (3) a prone thoracic manipulation by placing two hands over the transverse processes of T5-T6 or T6-T7 and applying a HVLA thrust in a posterior-to-anterior direction.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Control spinal manual therapy protocol
Description: (1) Control side-lying lumbar manipulation will be operationalised as the application of a low-velocity broad push manoeuvre to the gluteal region following a non-therapeutic line of drive. The chiropractor will then perform (2) control prone lumbar mobilisation, consisting of a non-therapeutic manual manoeuvre involving minimal oscillations (0 to ±2°) of the flexion-distraction piece with light touch over the lumbar spine region, and (3) control prone thoracic mobilisation consisting of two-handed left and right scapula pushes with a nontherapeutic line of drive.
Study: NCT05667922

Intervention type: DRUG
Intervention: Tacrolimus
Description: 0.05-0.10mg/kg/d, twice orally, with an interval of 12h. The drug valley concentration is 5-10ng/ml, which will be gradually reduced to a low dose after it is effective.

Intervention type: DRUG
Intervention: Tacrolimus
Description: 0.05-0.10mg/kg/d, twice orally, with an interval of 12h. The drug valley concentration is 5-10ng/ml, which will be gradually reduced to a low dose after it is effective.
Study: NCT05684809

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Post Isometric relaxation Technique (PIR)
Description: In PIR intervention, the patients were requested to lie down in a supine position and their neck was in a lateral flexion to the opposite side so that the target upper Trapezius muscle fibers would be in a lengthened position. The therapist performed a moderate isometric contraction (approximately 75% of maximal) of upper Trapezius muscles, held it for 5 seconds, then relaxed for 3 seconds before moving the cervical spine into the new barrier. In each session, this technique was repeated for four times, on alternate days for three weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cervical Mobilization (CM)
Description: Cervical Mobilization was delivered in prone lying with their foreheads resting comfortably on his hands, and the chin was tucked in.The treatment session was done on alternate days (3 days a week) for 3 weeks, hence the total number of sessions were 9.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional treatment
Description: Hot Pack was given for twenty minutes, slow sustained stretching exercises ( 20 second hold, 10-second relaxation) were given, and isometric exercise of the neck((10 repetitions of two sets with 10 seconds hold) alternate days for three weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional treatment
Description: Hot Pack was given for twenty minutes, slow sustained stretching exercises ( 20 second hold, 10-second relaxation) were given, and isometric exercise of the neck((10 repetitions of two sets with 10 seconds hold) alternate days for three weeks.
Study: NCT05330806

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collagenase chemonucleolysis
Description: After local anesthesia, and the puncture point was 8-12cm on the side of the paraspinous process under C arm fluoroscopy. The needle was punctured though the skin with an angle of 45-60 to the posterior of the vertebral via safe entry zone to the herniated site outside the intervertebral disc under the epidural space. The syringe was drawn back to confirm that no blood or cerebrospinal fluid was flowing out, Contrast agents were injected to make sure no flows out of the spinal canal. 600 unit collagenase was dissolved in 2ml normal saline and injected slowly with rate of 1ml per minute. The needle was removed and keep the dorsal elevated position for 6-8 hours. Keep away from load bear of lumbar for 3 months.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Percutaneous endoscopic lumbar discectomy (PELD)
Description: For L1-L4 segment, percutaneous endoscopic transforaminal discectomy(PETD) will be performed. An 1cm length incision was made at 8-14cm lateral of the paraspinous process, where a needle puncture to the superior articular process of the lower involved vertebrae of the herniated disc. A series of conical rods are to be introduced, subsequently a reamer is to be introduced through the cannula. After removal of the disc herniation, the cannula and endoscope are to be removed. For L5/S1 segment, percutaneous endoscopic interlaminar discectomy(PEID) was performed. An incision of nearly 7 mm was made at the entry point of the skin, and a series of expansion channels were sequentially inserted into the surface of the ligamentum flavum.Then, the ligamentum flavum and soft tissue around it were removed. Then, the tongue of the working cannula was inserted and rotated into the lateral nerve root. Removed the prominent nucleus pulposus by various nucleus pulposus forceps.
Study: NCT06217926

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Experimental Group (Educational content; ChatGPT and Google Bard training)
Description: Educational content; ChatGPT and Google Bard training for senior students of the Faculty of Health Sciences who volunteered to participate in the study was provided by Dr. Lecturer It will be given by member Yasemin Özyer Güvener. After the training is completed, students will be asked to use generative artificial intelligence for educational purposes.~During the posttest implementation of the study (one week before the final exams), the Personal Information Form, Attitude Scale Towards Artificial Intelligence and Westside Exam Anxiety Scale will be re-administered to the 3rd and 4th year students of the Faculty of Health Sciences.
Study: NCT05471453

Intervention type: DIETARY_SUPPLEMENT
Group type: SHAM_COMPARATOR
Intervention: DHEA
Description: 75 mg DHEA supplementation per day for 3 months before IVF

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: DHEA+CoQ10+Tocotrienol
Description: 75 mg DHEA supplementation + 30 mg CoQ10 + 300 mg Tocotrienol per day for 3 months before IVF
Study: NCT05578040

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Auricular acupressure
Description: To conduct this intervention, we used adhesive patches without Vaccaria seed to sham auricular acupressure at the cervical vertebra acupoint in the first trial phase and auricular acupressure at the cervical vertebra acupoint in the other two trial phases in 2 groups of auricular acupressure acupoints of the left and right cervical vertebra.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Auricular acupressure
Description: To conduct this intervention, we used adhesive patches without Vaccaria seed to sham auricular acupressure at the cervical vertebra acupoint in the first trial phase and auricular acupressure at the cervical vertebra acupoint in the other two trial phases in 2 groups of auricular acupressure acupoints of the left and right cervical vertebra.
Study: NCT06323629

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Adaptive recursive self-feedback procedure
Description: The intervention uses self-feedback alone to improve speech production. It adapts the complexity of the treatment tasks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Non-adaptive recursive self-feedback procedure
Description: The intervention uses self-feedback alone to improve speech production. However, it does not adapt the complexity of the treatment tasks.
Study: NCT05850923

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: speech competition training
Description: Speech competition training include voice competition training twice a day in adjunction with drug treatment, and the patients will be required to perform voice-related tasks according to the instruction.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: the soothing music
Description: the soothing music
Study: NCT05808413

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Informational Video
Description: This video emphasizes that vaccination against COVID-19 continues to be important, highlights the importance of seeking accurate information, and provides statistics about the estimated number of lives saved by vaccination and reported adverse events following vaccination in Canada.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Informational Video
Description: This video emphasizes that vaccination against COVID-19 continues to be important, highlights the importance of seeking accurate information, and provides statistics about the estimated number of lives saved by vaccination and reported adverse events following vaccination in Canada.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Informational Video
Description: This video emphasizes that vaccination against COVID-19 continues to be important, highlights the importance of seeking accurate information, and provides statistics about the estimated number of lives saved by vaccination and reported adverse events following vaccination in Canada.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Altruistic Video
Description: This video presents a vignette about a young adult woman who has many social interactions during her daily life. It shows that her decision to stay up-to-date on COVID-19 vaccination could help to protect those people she comes into contact with, who may be at greater risk from COVID-19 infection. Statistics are used to show that up to one-in-four people in Canada have underlying conditions that make them more vulnerable to COVID-19, and to quantify the number of surgeries that were delayed by pandemic-related disruptions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Altruistic Video
Description: This video presents a vignette about a young adult woman who has many social interactions during her daily life. It shows that her decision to stay up-to-date on COVID-19 vaccination could help to protect those people she comes into contact with, who may be at greater risk from COVID-19 infection. Statistics are used to show that up to one-in-four people in Canada have underlying conditions that make them more vulnerable to COVID-19, and to quantify the number of surgeries that were delayed by pandemic-related disruptions.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Individualistic Video
Description: This video presents a vignette about a young adult man who is very health-conscious. He is unsure about staying up-to-date on COVID-19 vaccination until he learns that COVID-19 infection can have serious and disruptive consequences even if someone is younger. Statistics are used to quantify the increased risk of severe symptoms in young adults who are not up-to-date on vaccination.
Study: NCT06175156

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Controlled analgesia/sedation
Description: During the pre anesthesia assessment, explain in detail to the patient the usage of the self-control pump and confirm that each patient can master it. Firstly, connect the self-control analgesic pump with a loading dose of 3 ml. Then, continuously pump in a mixture of propofol and remifentanil at a speed of 0.1 ml/kg/h. After the loading dose is completed, the examination can begin. During the operation, press the self-control handle according to the patient's sensation. Each press can quickly push 1ml of the medication, with a locking time of 1 minute

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Intravenous combined anesthesia
Description: Intravenous slow infusion of fentanyl 1 μ G/kg, midazolam 0.02mg/kg, slowly administer propofol 0.8-1mg/kg after 2 minutes (time greater than 60 seconds), and start the examination when the patient's consciousness disappears and they do not respond. During the surgery, propofol is interrupted to maintain the auditory evoked potential index (AAI) between 30-40.
Study: NCT06256653

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Freeze-dried blueberries
Description: * Participants will be supplied with an 8-week supply of Study Product and instructions of dosing.~* Participants will be instructed to mix one sachet of the Study Product either to breakfast, or dessert, or mixed with yoghurt daily for the next 56 days, starting on the same day, Day 1.~* Additional product will be supplied in case of delay of study visit or loss of Study Product.~* Participants will be provided with a stool collection kit and instructions for collecting and storing. Participants will collect stool samples at home, within 48 hours prior to their visit but preferably the morning, of their scheduled visit and bring it to the clinic.~* Participants will be provided with a urine collection kit and instructions for collecting and storing.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: * Participants will be supplied with an 8-week supply of Placebo Product and instructions of dosing.~* Participants will be instructed to mix one sachet of the Placebo Product either to breakfast, or dessert, or mixed with yoghurt daily for the next 56 days, starting on the same day, Day 1.~* Additional product will be supplied in case of delay of study visit or loss of Placebo Product.~* Participants will be provided with a stool collection kit and instructions for collecting and storing. Participants will collect stool samples at home, within 48 hours prior to their visit but preferably the morning, of their scheduled visit and bring it to the clinic.~* Participants will be provided with a urine collection kit and instructions for collecting and storing.
Study: NCT05741528

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SEP-363856
Description: SEP-363856 tablet
Study: NCT06098001

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Low dose dietary fiber
Description: Subjects will receive a low dose or high dose of the dietary fiber product in a dose esacalation design
Study: NCT04522661

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Vitrectomy
Description: Vitrectomy within 48 hours of randomisation
Study: NCT06098001

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: High dose dietary fiber
Description: Subjects will receive a low dose or high dose of the dietary fiber product in a dose escalation design
Study: NCT04522661

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Intravitreal antibiotics
Description: Intravitreal Antibiotics at 48 hours

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intravitreal antibiotics
Description: Intravitreal Antibiotics at 48 hours
Study: NCT05100511

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ERG electrode tests for fundus image-guided focal ERG
Description: Investigate the patient comfort, usability and signal-to-noise ratio of different commercial CE marked ERG electrodes.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Fundus image-guided focal ERG
Description: Record focal ERG from a healthy retinal area and from an area with visible symptoms.
Study: NCT06168266

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Eccentric bike
Description: Received eccentric cycling exercise

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional group
Description: Received conventional treatment