Study: NCT06693934

Intervention type: GENETIC
Group type: OTHER
Intervention: Risk assessment with biogenetic and clinical test to predict diabetes risk
Description: All participants will undergo genetic test and clinical measurement including body weight, body height, blood pressure, waist circumference and capillary blood glucose to predict diabetes risk with report explanation by doctors (for high risk, IGT and DM) and nurses (low risk). Genetic report will be updated annually for high risk and IGT group using updated clinical factors (e.g. age, BMI, BP).

Intervention type: GENETIC
Group type: OTHER
Intervention: Risk assessment with biogenetic and clinical test to predict diabetes risk
Description: All participants will undergo genetic test and clinical measurement including body weight, body height, blood pressure, waist circumference and capillary blood glucose to predict diabetes risk with report explanation by doctors (for high risk, IGT and DM) and nurses (low risk). Genetic report will be updated annually for high risk and IGT group using updated clinical factors (e.g. age, BMI, BP).

Intervention type: GENETIC
Group type: OTHER
Intervention: Risk assessment with biogenetic and clinical test to predict diabetes risk
Description: All participants will undergo genetic test and clinical measurement including body weight, body height, blood pressure, waist circumference and capillary blood glucose to predict diabetes risk with report explanation by doctors (for high risk, IGT and DM) and nurses (low risk). Genetic report will be updated annually for high risk and IGT group using updated clinical factors (e.g. age, BMI, BP).

Intervention type: GENETIC
Group type: OTHER
Intervention: Risk assessment with biogenetic and clinical test to predict diabetes risk
Description: All participants will undergo genetic test and clinical measurement including body weight, body height, blood pressure, waist circumference and capillary blood glucose to predict diabetes risk with report explanation by doctors (for high risk, IGT and DM) and nurses (low risk). Genetic report will be updated annually for high risk and IGT group using updated clinical factors (e.g. age, BMI, BP).

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Oral glucose tolerance test (OGTT) and cardiovascular-kidney-metabolic (CKM) risk factors
Description: High risk progressors will undergo OGTT and measurement of CKM factors at baseline. In those without IGT or diabetes, they will undergo OGTT and CKM risk factor assessment annually for 2 years. The IGT group will additionally have measurement of beta-cell function (HOMA indexes) and the DM group will additionally have autoimmune marker measurement.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Oral glucose tolerance test (OGTT) and cardiovascular-kidney-metabolic (CKM) risk factors
Description: High risk progressors will undergo OGTT and measurement of CKM factors at baseline. In those without IGT or diabetes, they will undergo OGTT and CKM risk factor assessment annually for 2 years. The IGT group will additionally have measurement of beta-cell function (HOMA indexes) and the DM group will additionally have autoimmune marker measurement.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Oral glucose tolerance test (OGTT) and cardiovascular-kidney-metabolic (CKM) risk factors
Description: High risk progressors will undergo OGTT and measurement of CKM factors at baseline. In those without IGT or diabetes, they will undergo OGTT and CKM risk factor assessment annually for 2 years. The IGT group will additionally have measurement of beta-cell function (HOMA indexes) and the DM group will additionally have autoimmune marker measurement.

Intervention type: DRUG
Group type: OTHER
Intervention: Medication
Description: Nurse and medical consultations and subsidized medications (metformin, statin, ARB) will be provided to the high risk progressor, IGT and diabetes groups as appropriate for control of glucose and CKM risk factors.

Intervention type: DRUG
Group type: OTHER
Intervention: Medication
Description: Nurse and medical consultations and subsidized medications (metformin, statin, ARB) will be provided to the high risk progressor, IGT and diabetes groups as appropriate for control of glucose and CKM risk factors.

Intervention type: DRUG
Group type: OTHER
Intervention: Medication
Description: Nurse and medical consultations and subsidized medications (metformin, statin, ARB) will be provided to the high risk progressor, IGT and diabetes groups as appropriate for control of glucose and CKM risk factors.

Intervention type: DEVICE
Group type: OTHER
Intervention: Continuous glucose monitoring (CGM) devices and/or weighing scale
Description: All high risk progressors will be given subsidized weighing scale and low-intensity laboratory assessments, nurse and doctor consultation, regular WhatsApp messages and webinars for 2 years. The IGT and DM group will receive additional subsidized CGM devices for empowerment.

Intervention type: DEVICE
Group type: OTHER
Intervention: Continuous glucose monitoring (CGM) devices and/or weighing scale
Description: All high risk progressors will be given subsidized weighing scale and low-intensity laboratory assessments, nurse and doctor consultation, regular WhatsApp messages and webinars for 2 years. The IGT and DM group will receive additional subsidized CGM devices for empowerment.

Intervention type: DEVICE
Group type: OTHER
Intervention: Continuous glucose monitoring (CGM) devices and/or weighing scale
Description: All high risk progressors will be given subsidized weighing scale and low-intensity laboratory assessments, nurse and doctor consultation, regular WhatsApp messages and webinars for 2 years. The IGT and DM group will receive additional subsidized CGM devices for empowerment.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Visit to family doctor with nurse education
Description: All participants in high risk, IGT and diabetes groups will have regular follow-up by family doctors and nurses.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Visit to family doctor with nurse education
Description: All participants in high risk, IGT and diabetes groups will have regular follow-up by family doctors and nurses.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Visit to family doctor with nurse education
Description: All participants in high risk, IGT and diabetes groups will have regular follow-up by family doctors and nurses.