Study: NCT05349097

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SAD IMG-004 30mg
Description: Each participant will be randomized to receive a single oral dose of 30mg IMG-004

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SAD IMG-004 100mg
Description: Each participant will be randomized to receive a single oral dose of 100mg IMG-004

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SAD IMG-004 200mg
Description: Each participant will be randomized to receive a single oral dose of 200mg IMG-004

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SAD IMG-004 400mg
Description: Each participant will be randomized to receive a single oral dose of 400mg IMG-004

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SAD IMG-004 600mg
Description: Each participant will be randomized to receive a single oral dose of 600mg IMG-004

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: SAD Placebo 30mg
Description: Each participant will be randomized to receive a single oral dose of 30mg matching placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: SAD Placebo 100mg
Description: Each participant will be randomized to receive a single oral dose of 100mg matching placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: SAD Placebo 200mg
Description: Each participant will be randomized to receive a single oral dose of 200mg matching placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: SAD Placebo 400mg
Description: Each participant will be randomized to receive a single oral dose of 400mg matching placebo

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: SAD Placebo 600mg
Description: Each participant will be randomized to receive a single oral dose of 600mg matching placebo

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MAD IMG-004 50mg
Description: Each participant will be randomized to receive daily oral dose of 50mg IMG-004 for 10 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: MAD Placebo 50mg
Description: Each participant will be randomized to receive daily oral dose of 50mg matching placebo for 10 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MAD IMG-004 150mg
Description: Each participant will be randomized to receive daily oral dose of 150mg IMG-004 for 10 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: MAD Placebo 150mg
Description: Each participant will be randomized to receive daily oral dose of 150mg matching placebo for 10 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MAD IMG-004 300mg
Description: Each participant will be randomized to receive daily oral dose of 300mg IMG-004 for 10 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: MAD Placebo 300mg
Description: Each participant will be randomized to receive daily oral dose of 300mg matching placebo for 10 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FE IMG-004 150mg
Description: A single dose of IMG-004 at 150 mg dose level will be administered to the participants in fed and fasted states