TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06626893

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: Functional tests
Description: Functional analyses will be performed on primary sample from each enrolled patient. Isolated blast cells are cultered and incubated with a specific library of drugs (175 drugs) at four different concentrations for 72 hours.

Intervention type: GENETIC
Group type: OTHER
Intervention: Next Generation Sequencing analysis
Description: For each patient, sequencing analyses will be performed on blast cells (for somatic mutations) and on epithelial cells from buccal swab (for germline mutations)

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: Microvesicles analysis
Description: Analyses on microvesicles isolated from both Bone Marrow samples and Peripheral Blood Samples will be performed to investigate the microenvironment of the disease.
Study: NCT06447948

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Keep Exercising and Stay Steady
Description: Digital Health, home exercise intervention containing a digital NHS approved falls prevention exercise App (Keep On Keep Up), fitness watches, telephone and/or social media communication, and behavior change techniques.~Currently (date, 13 May 2024) the intervention has not been developed with the community of practice group. Further details of the phase 1 and phase 2 interventions will be provided after the community of practice events.
Study: NCT04806035

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TG-1801
Description: It is a bispecific, first-in-class, CD47 and CD19 antibody

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TG-1801
Description: It is a bispecific, first-in-class, CD47 and CD19 antibody

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: TG-1801
Description: It is a bispecific, first-in-class, CD47 and CD19 antibody

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Ublituximab
Description: recombinant chimeric anti-CD20 monoclonal antibody, available in 25 mg/mL administered as an IV infusion once every 4 weeks
Study: NCT05814783

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: supported digital CBTI
Description: in session support for adherence to and engagement with digital CBTI

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: digital CBTI
Description: CBTI app
Study: NCT05422300

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Fed
Description: Subjects will be fed a mixed-macronutrient beverage at rest (0.75g/kg lean body mass of carbohydrates; 0.25g/kg lean body mass of protein). Amino acid composition of the protein will be modelled off the composition of egg. Leucine content will be enriched to 5% with \[13C\]-leucine.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Fed
Description: Subjects will be fed a mixed-macronutrient beverage at rest (0.75g/kg lean body mass of carbohydrates; 0.25g/kg lean body mass of protein). Amino acid composition of the protein will be modelled off the composition of egg. Leucine content will be enriched to 5% with \[13C\]-leucine.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Ex-Fed
Description: Participants will be subjected to a full-body resistance exercise protocol, consisting of an upper and lower body circuit. The upper body circuit will be a chest press and dumbbell row superset, whereas the lower body circuit will be leg press and leg extension (4 sets of 10 repetitions @ 75% of their 1 repetition max, respectively). The inter-set rest period will be 90 seconds.~Subjects will be fed a mixed-macronutrient beverage at rest (0.75g/kg lean body mass of carbohydrates; 0.25g/kg lean body mass of protein). Amino acid composition of the protein will be modelled off the composition of egg. Leucine content will be enriched to 5% with \[13C\]-leucine.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Ex-Fed
Description: Participants will be subjected to a full-body resistance exercise protocol, consisting of an upper and lower body circuit. The upper body circuit will be a chest press and dumbbell row superset, whereas the lower body circuit will be leg press and leg extension (4 sets of 10 repetitions @ 75% of their 1 repetition max, respectively). The inter-set rest period will be 90 seconds.~Subjects will be fed a mixed-macronutrient beverage at rest (0.75g/kg lean body mass of carbohydrates; 0.25g/kg lean body mass of protein). Amino acid composition of the protein will be modelled off the composition of egg. Leucine content will be enriched to 5% with \[13C\]-leucine.
Study: NCT06516848

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High Intensity Inspiratory Muscle Training Group (H-IMT)
Description: Respiratory muscle strengthening training will be given with a resistive threshold inspiratory muscle strengthening device. Initially, it will be worked out vigorously at 80% of the maximum inspiratory pressure determined by mouth pressure measurement. The load will be increased weekly.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low Intensity Inspiratory Muscle Training Group (L-IMT)
Description: Respiratory muscle strengthening training will be given with a resistive threshold inspiratory muscle strengthening device. Initially, it will be worked out vigorously at 30% of the maximum inspiratory pressure determined by mouth pressure measurement. The load will be increased weekly.
Study: NCT05128240

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 1g corn oil capsules

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Ceto 10
Description: 1g capsules containing oil broad spectrum marine oil from north atlantic fish
Study: NCT06438952

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Transforaminal steroid injection combined with lumbar sympathetic blockade
Description: Transforaminal steroid injection will be made with 2 mg dexamethason + 20 mg lidocaine + 5mg bupivacaine + 5 mcg fentanyl + 100mg magnesium under US-guidance Lumbar sympathetic blockade will be made with 5 ml 0.5% bupivacaine + 6 mg dexamethason + 10 ml NaCl
Study: NCT05986656

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Atlas-Standard method
Description: Hardware acupressure of the suboccipital muscles according to the Atlas-Standard method for the reduction of chronic subluxation of the first cervical vertebra.
Study: NCT06482879

Intervention type: DEVICE
Intervention: Oxygen delivery
Description: Oxygen is delivered with high flow nasal canula or simple nasal canula to prevent hypoxia during procedures under deep sedation.

Intervention type: DEVICE
Intervention: Oxygen delivery
Description: Oxygen is delivered with high flow nasal canula or simple nasal canula to prevent hypoxia during procedures under deep sedation.
Study: NCT04436913

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Himalaya complete care toothpaste
Description: Herbal toothpaste as a part of a caries preventive regimen

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Signal toothpaste
Description: fluoride based toothpaste as a part of a caries preventive regimen
Study: NCT06438952

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Transforaminal steroid injection only
Description: Transforaminal steroid injection will be made with 2 mg dexamethason + 20 mg lidocaine + 5mg bupivacaine + 5 mcg fentanyl + 100mg magnesium under US-guidance
Study: NCT06122064

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Best Practice
Description: Receive standard of care

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Best Practice
Description: Receive standard of care

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Communication Intervention
Description: Use shared decision-making conversation tool

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Electronic Health Record Review
Description: Ancillary studies

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Electronic Health Record Review
Description: Ancillary studies

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Survey Administration
Description: Ancillary studies

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Survey Administration
Description: Ancillary studies

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Video Recording
Description: Ancillary studies

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Video Recording
Description: Ancillary studies
Study: NCT05177263

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Sterile Water

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 10% Oral Dextrose Solution
Description: 10% Oral Dextrose Solution

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 20% Oral Dextrose Solution
Description: 20% Oral Dextrose Solution

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: 30% Oral Dextrose Solution
Description: 30% Oral Dextrose Solution
Study: NCT04891653

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BR790
Description: Subjects will receive oral administration of BR790.
Study: NCT05998499

Intervention type: OTHER
Intervention: Description
Description: This study aimed to understand the situation of Latin American HIV-positive migrants seeking asylum in Spain and identify the challenges they encounter in getting HIV treatment. The main result measured was the proportion of participants with an HIV-1 RNA level of 50 copies/mL or higher at their first clinic visit
Study: NCT05415111

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Subepithelial connective tissue
Description: Study specific intervention is the placement of a soft tissue autogenous graft (SCTG) in addition to bone grafting of periimplantitis-affected implants.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Volume stable Collagen Matrix
Description: Study specific intervention is the placement of a soft tissue substitute (VCMX) in addition to bone grafting of periimplantitis-affected implants.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: No soft tissue augmentation
Description: Study specific control intervention is the placement of a bone graft at periimplantitis-affected implants. No soft tissue grafts will be placed.
Study: NCT04436913

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Signal toothpaste and fluoride varnish
Description: application of fluoride varnish and using fluoride based toothpaste
Study: NCT05066815

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Vita Enamic (Hybrid dental ceramic)
Description: Vita Enamic (Hybrid dental ceramic) is provided as blocks to be milled using Computer aided design/Computer aided manufacturer (CAD/CAM) technology.
Study: NCT03685240

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SafelyYou Fall Prevention System
Description: Technology + Quality Assurance Services Provided by SafelyYou
Study: NCT04582643

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: 6P intervention
Description: 6P assessment targeting on diet, activity and mentality, along with education provided based on the 6P components. The 6P tool serves the functions to help the women to self-monitor and be aware of their negative lifestyle choices.
Study: NCT04056429

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: BHA
Description: BHA active ingredients include beta-tricalcium phosphate and a blood-derived component. It is applied directly to the bone fracture and nearby viable bone at the time of wound closure.
Study: NCT06308445

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rapamycin
Description: This is a 2-dose rapamycin safety study, with a target through level of 3 to \<5 ng/ml for the first 3 months and 5-8 ng/ml for the next 3 months for each of the included patients. To avoid the possible cumulative effect, the two treatment phases will be separated by a 3-weeks wash-out period.
Study: NCT05066815

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Vita Enamic (Hybrid dental ceramic)
Description: Vita Enamic (Hybrid dental ceramic) is provided as blocks to be milled using Computer aided design/Computer aided manufacturer (CAD/CAM) technology.
Study: NCT05052645

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Auricular acupuncture
Description: Placement of acupuncture needles in specific points on the ear in two consecutive treatments spaced 7 days apart.
Study: NCT05207462

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intensive treatment with prolonged exposure
Description: Intensive treatment with prolonged exposure
Study: NCT05877612

Intervention type: DEVICE
Intervention: Implantable spinal cord stimulator
Description: Spinal cord stimulation is possible thanks to implantable spinal cord neurostimulators. These are medical devices, which include a stimulation electrode and an implantable box, designed to deliver electrical stimulation for pain relief. The electrode is implanted in the epidural space in order to stimulate the posterior cords of the spinal cord through the dura mater, at the dorsal or cervical level.
Study: NCT05020912

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ALA
Description: At first visit, ALA applied to one BCC lesion

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: PDT
Description: PDT with blue light (for 30 min (\~20 mJ/cm2))
Study: NCT05037383

Intervention type: OTHER
Group type: OTHER
Intervention: Video recordings
Description: The surgery of the patient will be recorded by cameras placed on the top of the displays used by the operating staff. The recordings will be only carried out while the patient is draped for the surgery, thus completely covered.
Study: NCT06399549

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Dead bug exercise
Description: the participant in supine, lying on a mat with shoulders, hip joints and knees flexed to 90°. With the lumbopelvic region being maintained in the neutral position, the participant will be instructed to draw in the abdomen, lower two contra lateral limbs (opposite arm and leg) toward the floor, hold for the stipulated time, then return to starting position. The same movement will be repeated with the opposite limbs. In the DBG, both pairs of limbs will be moved an equal number of times withinthe stipulated time. The patients in both groups will perform the corresponding exercises 3 days a week for a period of 3 weeks and a rest interval of 2 minutes between exercises along with conventional physiotherapy exercises.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: The McGill Curl Up
Description: Lie down on your back. Extend one leg and bend the knee of the other leg. The Side Bridge. Lie on your side, with your forearm on the floor and elbow underneath your shoulder.~The Bird Dog. Assume a hands-and-knees position on the floor. The patients in both groups will perform the corresponding exercises 3 days a week for a period of 3 weeks and a rest interval of 2 minutes between exercises along with conventional physiotherapy exercises. The exercise program includes a warm-up session of five exercises (awareness of the back, pelvic tilt, lumbar rotation, arm movements, whole-body movement in standing), well-known exercises targeting the muscles of the back extensors, abdominals, lateral buttocks, trunk rotators, posterior buttocks, leg muscles, oblique abdominals (e.g. the plank, diagonal arm and leg lift), as well as exercises for flexibility. The exercises will be taught to the patients at the end of the first session in both groups.
Study: NCT04696406

Intervention type: DEVICE
Intervention: RESPINOR DXT
Description: Blinded, continuous diaphragmatic excursion measurements by DXT will be conducted during the patients' first SBT. The recording shall be initiated 15 minutes prior to the first SBT and will end 15 minutes post SBT.

Intervention type: DEVICE
Intervention: RESPINOR DXT
Description: Blinded, continuous diaphragmatic excursion measurements by DXT will be conducted during the patients' first SBT. The recording shall be initiated 15 minutes prior to the first SBT and will end 15 minutes post SBT.
Study: NCT06288178

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Bread consumption
Description: There were four groups: whole wheat (WWB), buckwheat (BWB), corn bread (CB) and reference bread.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Bread consumption
Description: There were four groups: whole wheat (WWB), buckwheat (BWB), corn bread (CB) and reference bread.
Study: NCT05180656

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Yoga Intervention
Description: The yoga intervention will consist of two 60-minute yoga classes each week, taught by a certified yoga instructor and delivered remotely through videoconferencing. Participants will be asked to participate in the intervention for 8 weeks.
Study: NCT05226689

Intervention type: DEVICE
Group type: OTHER
Intervention: POROUS TIBIA BASEPLATE W/ JRNY LOCK
Description: Fixed-bearing POROUS TIBIA BASEPLATE W/ JRNY LOCK and a Legion cruciate-retaining High-Flex or Deep-dish XLPE tibial insert
Study: NCT05957341

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: active rTMS: 20min inter-session interval
Description: Participants will receive active TMS, with 3 sessions per day, 1800 pulses/session, and 20 min inter-session intervals, lasting for 21 days. Individualized targets will be generated using the pBFS method.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: active rTMS: 50min inter-session interval
Description: Participants will receive active TMS, with 3 sessions per day, 1800 pulses/session, and 50 min inter-session intervals, lasting for 21 days. Individualized targets will be generated using the pBFS method.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: sham rTMS: 20min inter-session interval
Description: The parameters in this group are the same as in the active rTMS: 20min inter-session interval group. Stimulation was delivered by the same device as the active group fitted with a sham coil.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: sham rTMS: 50min inter-session interval
Description: The parameters in this group are the same as in the active rTMS: 50min inter-session interval group. Stimulation was delivered by the same device as the active group fitted with a sham coil.
Study: NCT03750838

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Text Messaging Intervention
Description: The content for the text messaging Intervention will be designed to be non-confrontational in tone, seek to increase motivation to drink lightly or not at all, and based both on general information about light and non-drinking as well as information provided during the baseline assessment.
Study: NCT05904366

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: MR Spectroscopy (MRS)
Description: MR Spectroscopy (MRS)

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: MR Spectroscopy (MRS)
Description: MR Spectroscopy (MRS)

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: MR Elastography (MRE)
Description: MR Elastography (MRE) with a device that induces shear waves in the body. This device is placed upon the abdomen of the subject and is hold in place by straps. The device will produce low-frequency vibrations (e.g. 30-60 Hz) which are not painful to the participant. A declaration of conformity and a safety document are provided in the study dossier.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: MR Elastography (MRE)
Description: MR Elastography (MRE) with a device that induces shear waves in the body. This device is placed upon the abdomen of the subject and is hold in place by straps. The device will produce low-frequency vibrations (e.g. 30-60 Hz) which are not painful to the participant. A declaration of conformity and a safety document are provided in the study dossier.
Study: NCT04843904

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Venetoclax
Description: Tablet, taken by mouth

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Obinutuzumab
Description: Given as an infusion into the vein (intravenous, IV).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rituximab
Description: Given as an infusion into the vein (intravenous, IV).
Study: NCT04723368

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Automated flying Drone carrying an Automated external defibrillator (AED)
Description: Totally n=5 drones are equipped with automated external defibrillators (AEDs). These drones are deployed by the dispatch centre to cases of suspected out-of-hospital cardiac (OHCA) as a complement to standard care (ambulance/EMS) over up to 14 months during daytime Monday to Sunday 08:00-22:00. The bystander onsite receives instructions from the dispatcher to retrieve the AED outside the house when it has been delivered by the drone. The bystander attaches the AED to the patients chest to facilitate early defibrillation.
Study: NCT05023655

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tazemetostat
Description: 800mg po twice daily
Study: NCT05434676

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Shockwave Medical Peripheral Intravascular Lithotripsy (IVL) System M5 & S4
Description: To assess the safety and effectiveness of IVL treatment used in combination with DCB to treat moderate and severely calcified femoropopliteal arteries
Study: NCT05162391

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Contingency Management
Description: Contingency management intervention with incentives tied to provision of urine samples with no detectable levels of methamphetamine (MA).
Study: NCT05467137

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MSOT
Description: MSOT imaging (after ICG injection)
Study: NCT05753475

Intervention type: OTHER
Intervention: renal transplantation
Description: patients undergoing renal transplantation

Intervention type: OTHER
Intervention: renal transplantation
Description: patients undergoing renal transplantation
Study: NCT05520177

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 601 1.25mg
Description: loading phase (6 months): 601 1.25mg/eye/time, Intravitreal injection, administered once every 4 weeks for 6 consecutive doses

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ranibizumab 0.5mg
Description: loading phase (6 months): ranibizumab 0.5mg/eye/time, Intravitreal injection, administered once every 4 weeks for 6 consecutive doses
Study: NCT06738030

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial current stimulation
Description: The transcranial alternating current stimulation is delivered during the speech stimulus and the current matches the envelope of the target speech

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Auditory training
Description: An at-home auditory training program that adaptively and interactively trains the listener in degraded speech, cognitive skills, and communication strategies