TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05720741

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Project THINK
Description: Project THINK is a 30-minute self-guided digital intervention designed to teach children and adolescents how to change the way that they think. Specifically, Project THINK is based on the principles of cognitive restructuring, a core component of cognitive behavioral therapy, a gold standard treatment for internalizing disorders. Project THINK uses vignettes, interactive activities, and engaging graphics to teach youth a systematic strategy for assessing the presence of unhelpful thoughts and replacing them with more helpful ones. Although never formally tested in a randomized trial, Project Think has been used by hundreds of students, and feedback has been very positive.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Project SHARE
Description: Intervention delivered in a web browser that focuses on encouraging feelings disclosure to trusted others using facts about the brain, testimonials from peers, and writing exercises (also referred to as Sharing Feelings Intervention; Schleider et al., 2021).
Study: NCT04142736

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Prone Position
Description: The best-fitting and most-tolerated oxygen interface will be used in the prone position--this could be different from patient to patient, and different from what is used in the supine position, and could differ between patients but also institutions (i.e., depending on the availability of masks with or without a reservoir bag and with or without the Venturi system, HFNO, CPAP or NIV). The patient will be placed in the prone position for at least 2 hours, which may be prolonged if the patient is comfortable or interrupted if the patient presents any criteria for prone position discontinuation. After the prone position period, the patient will be rotated to the semi-recumbent supine position for at least 2 hours and a maximum of 4 hours. This 2-hour time frame will depend on nursing availability, need for hygiene, complementary explorations, or diet.
Study: NCT05081414

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Program for Teaching Self-Care in HF (PEAC-IC)
Description: As described previously
Study: NCT05248893

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AGN-151586
Description: Intramuscular Injection
Study: NCT04993690

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LP-168 tablet
Description: Subjects to take LP-168 orally with 240mL water, without food, Once daily or twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LP-168 tablet
Description: Subjects to take LP-168 orally with 240mL water, without food, Once daily or twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LP-168 tablet
Description: Subjects to take LP-168 orally with 240mL water, without food, Once daily or twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LP-168 tablet
Description: Subjects to take LP-168 orally with 240mL water, without food, Once daily or twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LP-168 tablet
Description: Subjects to take LP-168 orally with 240mL water, without food, Once daily or twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LP-168 tablet
Description: Subjects to take LP-168 orally with 240mL water, without food, Once daily or twice daily
Study: NCT05893654

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Melphalan Injection
Description: 7.5mg of melphalan injected via intra-arterial catheterization of the ophthalmic artery.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Plaque brachytherapy
Description: Brachytherapy will be performed using a 24-mm notched plaque with Ruthenium-106 seeds.
Study: NCT05801640

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Facilitated Tucking Position
Description: The fetal position was given by the researcher. In the fetal position, the lower and upper extremities of the baby were kept in the flexed position by hand and placed in the side-lying position close to the midline.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Reiki
Description: Reiki was applied to areas called chakras (forehead, throat, heart, stomach, feet and hands). A total of 15 minutes were applied in the form of 12 minutes touches in each chakra region.
Study: NCT06541613

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: local anesthetic injection (bupivacaine)
Description: The in-plane technique with a 22G, 80 mm block needle is used to inject 30 ml of 0.25% bupivacaine into the external oblique intercostal plane on both sides.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: normal saline injection
Description: the control group will receive 30ml of normal saline bilaterally into the external oblique intercostal plane on both sides
Study: NCT06542770

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Early implant of cardiac monitor
Description: ICM implant 3-4 days after the stroke and prior to discharge. All devices (Abbott Confirm or Jot) were implanted subcutaneously under local anaesthesia in the left chest region and programmed with an specific algorithm for AF detection set at 30 seconds for detection. All patients were included in remote monitoring system (Merlin), which was programmed to send alerts in case of registering episodes qualifying for AF detection, and a monthly routine registration. All ICM recordings were reviewed by a specialized cardiologist.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Early implant of cardiac monitor
Description: ICM implant 3-4 days after the stroke and prior to discharge. All devices (Abbott Confirm or Jot) were implanted subcutaneously under local anaesthesia in the left chest region and programmed with an specific algorithm for AF detection set at 30 seconds for detection. All patients were included in remote monitoring system (Merlin), which was programmed to send alerts in case of registering episodes qualifying for AF detection, and a monthly routine registration. All ICM recordings were reviewed by a specialized cardiologist.
Study: NCT06284707

Intervention type: OTHER
Group type: OTHER
Intervention: swimming training
Description: 2 sessions per week of swimming training

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: swimming training
Description: 2 sessions per week of swimming training

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: rhythmic gymnastics training
Description: 2 training sessions of rhythmic gymnastics
Study: NCT06037031

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Drug: PF-07923568
Description: A single dose of PF-07923568 administered orally as 4 capsules

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Drug: PF-07923568
Description: A single dose of PF-07923568 administered orally as 4 capsules

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Drug: PF-07923568
Description: A single dose of PF-07923568 administered orally as 4 capsules
Study: NCT05027217

Intervention type: OTHER
Intervention: No intervention
Description: No intervention. Arms are subdivided based on patients' diagnostic status on admission to ICU.

Intervention type: OTHER
Intervention: No intervention
Description: No intervention. Arms are subdivided based on patients' diagnostic status on admission to ICU.

Intervention type: OTHER
Intervention: No intervention
Description: No intervention. Arms are subdivided based on patients' diagnostic status on admission to ICU.
Study: NCT06635460

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Motivational interviewing
Description: This programme has been developed from the literature and structured according to expert opinion. It will consist of a total of 8 online sessions. The duration of the motivational interviewing sessions will be limited to 30-45 minutes, in line with the literature.
Study: NCT06309472

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mirtazapine
Description: 30mg mirtazapine at night, escalated to 45mg after 4 weeks if \<20 percent improvement in depression from baseline. Total treatment duration 12 weeks.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 1 placebo capsule at night, escalated to 2 capsules after 4 weeks if \<20 percent improvement in depression from baseline. Total treatment duration 12 weeks.
Study: NCT04506125

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Haemoglobin 9.5 g/dL
Description: transfusion of red blood cell concentrate if the haemoglobin level is less than 9,5 g/dL

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Haemoglobine 7.5g/dL
Description: transfusion of red blood cell concentrate if the haemoglobin level is less than 7,5 g/dL
Study: NCT06635460

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Social media-based patient monitoring
Description: Blood glucose results, lowest and highest values, and reasons will be included in the content of the patient follow-up, which will be conducted at intervals on the WhatsApp platform. There will be a total of 10 follow-ups. Although the duration of the written dialog will vary among adolescents, it will be limited to an average of 2-10 minutes.
Study: NCT06636058

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: vCare Intervention (6-month active treatment followed by 6-month maintenance)
Description: During the active treatment, participants will interact with the Lumen virtual coach (for depression management) and watch the GLB videos (for weight loss). Using the Amazon Alexa app on their study iPads, participants will complete 4 weekly Lumen PST sessions initially, 2 bi-weekly sessions, and then 3 monthly sessions during the active intervention. Beginning in week 6, participants will receive automated messages with instructions to view one GLB video a week for 11 weeks.~During the maintenance period, participants in the early vCare intervention arm will be able to interact with Lumen for PST coaching when they need to, i.e., on demand, although they will receive reminders to do so at least once a month. Participants may watch any of the 12 GLB videos again and will receive GLB-themed reinforcement and motivational messages by email every 2 weeks.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: vCare Intervention (active treatment after 6 months)
Description: During the active treatment, participants will interact with the Lumen virtual coach (for depression management) and watch the GLB videos (for weight loss). Using the Amazon Alexa app on their study iPads, participants will complete 4 weekly Lumen PST sessions initially, 2 bi-weekly sessions, and then 3 monthly sessions during the active intervention. Beginning in week 6, participants will receive automated messages with instructions to view one GLB video a week for 11 weeks.
Study: NCT06106477

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Intermittent Fasting
Description: Participants will be asked to adhere to a six-month intermittent fasting intervention, a daily-recurring dietary plan consisting of:~* An approximately fourteen-hour nightly fasting period that is followed by~* An approximately ten-hour eating period with their last meal of the day occurring between 17:00 (5:00 PM) and 21:00 (9:00 PM).
Study: NCT05093517

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: REMD-477
Description: A biologic glucagon receptor agonist to which randomized subjects are assigned 2:1

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Subcutaneous injection
Description: Placebo for REMD-477 to which subjects will be randomized 1:2.
Study: NCT05290883

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Novel yoghurt drink containing Polar Lipids
Description: Postprandial decreased platelet activation/aggregation in subjects, after the yoghurt drink consumption
Study: NCT05106140

Intervention type: OTHER
Intervention: Magnetic Resonance Imaging (MRI)
Description: A research MRI will be performed at 6-weeks post-stroke to document stroke lesion location and size.
Study: NCT05037942

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood flow restriction at 40% limb occlusion pressure
Description: A 13-cm-wide pneumatic cuff will be applied to the most proximal portion of the chosen thigh (as determined by randomisation), immediately distal to the inguinal fold, prior to a bout of lower-body resistance exercise. The cuff will be inflated to 40% of limb occlusion pressure pressure and will remain inflated throughout the exercise (total occlusion time: \~5 mins).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood flow restriction at 80% limb occlusion pressure
Description: A 13-cm-wide pneumatic cuff will be applied to the most proximal portion of the chosen thigh (as determined by randomisation), immediately distal to the inguinal fold, prior to a bout of lower-body resistance exercise. The cuff will be inflated to 80% of limb occlusion pressure pressure and will remain inflated throughout the exercise (total occlusion time: \~5 mins).
Study: NCT05037552

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Bipolar coagulation
Description: Cystectomy will be done via laparoendoscopic surgery After identifying the correct plane of cleavage, the stripping technique will be used. The cyst wall will be gently pulled down from the remaining ovary with two pairs of atraumatic forceps.~Once the whole cyst wall will be separated from the ovary cortex, bleeding of the remaining ovarian stromal tissue will be controlled by bipolar coagulation. Then, the remnant tissue will be examined using irrigation and coagulated with minimal bipolar power (20-W current) on any sites that are bleeding.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Coagulation by FLOSEAL haemostatic agent
Description: Cystectomy will be done via laparoendoscopic surgery After identifying the correct plane of cleavage, the stripping technique will be used. The cyst wall will be gently pulled down from the remaining ovary with two pairs of atraumatic forceps.~Once the whole cyst wall will be separated from the ovary cortex, bleeding of the remaining ovarian stromal tissue will be controlled by either hemostatic sealants (FloSeal). Using a laparoscopic applicator, FloSeal will be applied to the surface of bleeding sites under direct vision and the ovarian cortex was gently pressed for 2 min with small gauze.
Study: NCT04854616

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CoSTED Intervention
Description: Brief smoking cessation advice, the provision of an e-cigarette starter kit and training in its use, and referral to stop smoking services.
Study: NCT05143437

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Love Together Parent Together
Description: A brief, low-intensity writing intervention adapted for parents of young children, designed to reduce conflict-related distress, prevent relationship deterioration and encourage the use of conflict reappraisal strategies designed to reduce conflict-related distress, etc.
Study: NCT05800704

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Nagasin
Description: Lactobacillus, Lactococcus and Bifidobacteria strains with antimicrobial effect against C. difficile

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: maltodextrin
Description: maltodextrin (placebo comparator)
Study: NCT05930509

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Non-invasive transcranial direct current stimulation (tDCS)
Description: Electrical stimulation
Study: NCT04895228

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: injection
Description: triamcinilone 40 mg injection (Kenacort) + 4 ml of .5 % lidocaine hydrochloride (Xylocaine) under ultrasound guidance

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: injection
Description: triamcinilone 40 mg injection (Kenacort) + 4 ml of .5 % lidocaine hydrochloride (Xylocaine) under ultrasound guidance
Study: NCT05197959

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Repetitive transcranial magnetic stimulation
Description: Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive, non-painful procedure used to relieve chronic pain and promote short-term changes. The abductor pollicis brevis (APB) muscle of the left motor cortex will be targeted using neuronavigation software. 2000 pulses will be delivered at 10 Hz stimulation. Stimulation will be delivered at 80% of the resting motor threshold obtained from the right APB muscle. The delivery of rTMS requires \~ 11.5 minutes in total.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sensorimotor training
Description: Sensorimotor training is a non-invasive, non-painful procedure using nerve stimulation to cue motor action. Nerve stimulation is applied the second through the fifth digit and the median nerve at the wrist. This stimulation is used to cue a motor action. The number of stimulations will indicate the amount of movements. For example, two pulses of stimulations to the index finger would require two flexion and extension actions with the index finger. Once the stimulation occurs, the participant will flex and extend the corresponding area where the nerve stimulation was felt. This will take \~ 30 minutes to complete.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Sensorimotor training
Description: Sensorimotor training is a non-invasive, non-painful procedure using nerve stimulation to cue motor action. Nerve stimulation is applied the second through the fifth digit and the median nerve at the wrist. This stimulation is used to cue a motor action. The number of stimulations will indicate the amount of movements. For example, two pulses of stimulations to the index finger would require two flexion and extension actions with the index finger. Once the stimulation occurs, the participant will flex and extend the corresponding area where the nerve stimulation was felt. This will take \~ 30 minutes to complete.
Study: NCT06231550

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FC084CSA tablets
Description: FC084CSA accelerated doses at 100mg QD, and then started the conventional 3+3 design from 200mg QD.
Study: NCT05263531

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: remote ischemic conditioning
Description: RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral arms and inflated to design pressure for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: remote ischemic conditioning
Description: RIC is a physical strategy performed by an electric autocontrol device with cuffs placed on bilateral arms and inflated to design pressure for 5-min followed by deflation for 5-min, the procedures is performed repeatedly for 5 times.
Study: NCT06266923

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SPH6516 tablets
Description: SPH6516 tablets ： Orally, once daily, 25-200mg, 28 days a cycle
Study: NCT05106140

Intervention type: DEVICE
Intervention: Kinarm Robotic Exoskeleton Assessment
Description: The Kinarm Robotic Exoskeleton is a device used to provide therapy and assessment. The device has framework that supports the arms and these supports are adjustable to ensure a comfortable fit. Motors attached to the framework move the arms and record shoulder and elbow movements.~The assessment involves performing a number of tasks using the Kinarm to measure proprioceptive and motor impairment, adaptation to force and visual disturbances, and retention after 24 hours.
Study: NCT05113901

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methylprednisolone
Description: 21 x 4mg tablets at 6 weeks, qualifying for MUA if ROM \<90° at 8 weeks

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: 21 sugar tablets at 6 weeks with standard management, qualifying for MUA if ROM \<90° at 8 weeks
Study: NCT06539273

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Exosome Complex, RNA
Description: A total of 3 mL of exosomes (2 mL to the frontal and 1 mL to the vertex region) was injected using napage technique (10¹⁰ extracellular vesicles in 1 mL)
Study: NCT05351073

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NBO
Description: Oxygen inhalation through a mask at a rate of 10 L/min at 1 absolute atmosphere pressure (1 ATA = 101.325 kPa)
Study: NCT06506097

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Family-school Partnership Intervention (FSPI)
Description: FSPI includes implementation activities across multiple levels.~FSPI Planning Team Meetings will be held monthly to plan project activities, practice staff and parent coaching strategies, and troubleshoot implementation challenges.~FSPI Staff Training (3 hours) will be provided during a single professional development day (3 hours), and attended by members of the FSPI Planning Team and teachers.~FSPI Playgroups. Over the course of the school year, each parent-child dyad will be invited to participate in three FSPI Playgroup events. Typically, teachers from two classrooms will collaborate in hosting playgroup events, and each playgroup will be attended by four parent-child dyads (i.e., two per classroom). Teachers will be provided with a curriculum and learning outcomes to target.~FSPI Debrief Meetings are held after each FSPI Playgroup to debrief, reflect, and improve FSPI implementation.
Study: NCT05124431

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anlotinib hydrochloride
Description: Anlotinib hydrochloride is a multi-target receptor tyrosine kinase inhibitor.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: everolimus
Description: 5mg po，qd
Study: NCT06242873

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gait training with/without TSCS
Description: To assess the safety and impact of paired stimulation and training on gait in children with iSCI, participants will participate in 24 total sessions. Two sessions will involve assessment only and 22 sessions will include two hours of therapy. Sessions will occur at least three times per week, but may be scheduled as many as five times per week. In each session, participants will receive 60 minutes of treadmill training followed by strengthening, segmental task practice, and gait-based interventions. Participants will receive stimulation based on their group assignment (TSCS or sham).

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Gait training with/without TSCS
Description: To assess the safety and impact of paired stimulation and training on gait in children with iSCI, participants will participate in 24 total sessions. Two sessions will involve assessment only and 22 sessions will include two hours of therapy. Sessions will occur at least three times per week, but may be scheduled as many as five times per week. In each session, participants will receive 60 minutes of treadmill training followed by strengthening, segmental task practice, and gait-based interventions. Participants will receive stimulation based on their group assignment (TSCS or sham).