TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05798481

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mixture of Sodium Nitrite and N-acetylcysteine (NAC) crytals.
Description: Exactly 2.5 mg or 5 mg sodium nitrite and 50 mg N-acetylcysteine are weighed and mixed together just before use. The mixture is placed under the participant's tongue. The powder slowly dissolves in saliva and generate S-nitrosoacetylcysteine. Investigators will ask the subjects not to swallow the drug at least for 30 min. Administration of nitrite and N-acetylcysteine individually at these concentrations is not expected to change any blood NO chemistry or the systemic blood pressure. Hence, investigators will not investigate the effects of nitrite and N-acetylcysteine individually in this study. Placebo control is not needed for this study because the baseline parameters will serve as control. Investigators will assess the drug effect based on the difference between pre-treatment and post-treatment values.
Study: NCT00633230

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: standardized herbal formula, Sho-saiko-to (SST)
Description: 3 capsules containing 700 mg of the Sho-saiko-to (SST) herbal extract/capsule and 28 mg of the excipients, magnesium stearate, and silicon dioxide/capsule 2 x day

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo capsule identical to the active herbal formula
Description: 3 placebo capsules 2 x day
Study: NCT06000631

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Ride-On Car Training in a standing posture with a 2-hour session
Description: A licensed, independent therapist and caregivers will provide the training program in the public space in the university for a total of 12-week intervention based on ecological and dynamic systems theories. Training will concentrate on building the concept of casual effect on the control system and car motion, practicing goal-oriented driving (e.g., driving 200 meters and reach for a toy or contact with a person, play hide-and-seek) in certain public spaces, including hallways, convenient stores, garden, museum and upper limb use in functional tasks with driving, facilitating hand use in functional tasks for exploration and applying various motor skills for mobility and socialization in natural play session. Every week's treatment program will preplanned and adjusted by the therapist and the caregivers through discussion and clinical observation of participant's performance in the previous session. Participants will continue their regular therapy during the whole study.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Ride-On Car Training in a standing posture with a 1-hour session
Description: A licensed, independent therapist and caregivers will provide the training program in the public space in the university for a total of 24-week intervention based on ecological and dynamic systems theories. Training will concentrate on building the concept of casual effect on the control system and car motion, practicing goal-oriented driving (e.g., driving 200 meters and reach for a toy or contact with a person, play hide-and-seek) in certain public spaces, including hallways, convenient stores, garden, museum and upper limb use in functional tasks with driving, facilitating hand use in functional tasks for exploration and applying various motor skills for mobility and socialization in natural play session. Every week's treatment program will preplanned and adjusted by the therapist and the caregivers through discussion and clinical observation of the participant's performance in the previous session. Participants will continue their regular therapy during the whole study.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Conventional Therapy with a 1-hour session
Description: The other independent OT will be responsible for providing conventional therapy in the same location as the ROC-Stand training for a total of 24-week intervention based on the developmental and motor learning theories. The goals are to improve certain motor skills or psychosocial skills based on each participant's current developmental stage. The general purpose of the training is to facilitate the developmental scales and improve mobility, socialization, and upper limb use in functional tasks.
Study: NCT05886530

Intervention type: OTHER
Intervention: No intervention
Description: Observational data collection only.

Intervention type: OTHER
Intervention: No intervention
Description: Observational data collection only.

Intervention type: OTHER
Intervention: No intervention
Description: Observational data collection only.

Intervention type: OTHER
Intervention: No intervention
Description: Observational data collection only.
Study: NCT05359133

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tetrodotoxin
Description: TTX for Injection, 30 µg/mL, is a sterile, nonpyrogenic, white, lyophilized powder provided in a 5 mL glass single-use vial with a rubber stopper and aluminum overseal. Upon reconstitution of the lyophilized product with 1.1 mL of sterile water for injection, each vial delivers 1 mL of fluid containing 30 µg of TTX with a pH of 4.0 to 5.5

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo for injection is a sterile 0.9% sodium chloride injection or normal saline for injection. To ensure blinding, subjects receiving placebo will receive the same volume (1.0 mL) for injection to match the volume used for the cohorts assigned to receive active trial drug.~Route and frequency: 1.0 mL of placebo, SC injection in the thigh or abdomen, twice daily for 4 Days in each treatment Cycle.
Study: NCT05991765

Intervention type: OTHER
Intervention: Digit Tip Wound
Description: Digit Tip Wound Exudate Sample Collected while Dressing Change

Intervention type: OTHER
Intervention: Split Skin Donor Site Wound
Description: Split Skin Donor Site Wound Exudate Sample while Dressing Change
Study: NCT05884515

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: SARS CoV-2 antigen tests
Description: The intervention is to compare antigen tests
Study: NCT04626089

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: metformin glycinate
Description: Participants randomized to metformin glycinate wil take 620 mg bid (PO) plus standard treatment for 14 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo oral tablet
Description: Participants randomized to placebo will take a tablet bid (PO) plus standard treatment for 14 days
Study: NCT05407051

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Family Centered Treatment
Description: In the Family-Centered Treatment Arm, parents would be given the same list of mental health referrals and crisis numbers, but in this condition, they would authorize researchers to share their contact information with the partner agency, Catholic Charities, and would then be linked directly to bilingual adult mental health services there with a behavioral health provider who would provide collateral therapy to parents via telehealth. Although parents will be referred to the community partner for therapy as a part of the research intervention, the behavioral health providers at the community partner will be providing therapy as they usually do for these participants in line with their usual job duties.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as Usual
Description: All participants (parents) would receive follow-up calls from a MetroHealth research personnel at 3 months and 6 months to measure changes in parent mental health outcomes, as well as satisfaction.~Children of parents in both conditions will receive treatment as usual which includes brief consultation for 3-5 sessions with an integrated MetroHealth behavioral health provider which is already standard practice in the clinic. Sessions typically occur monthly. Teens will be re-administered the Patient Health Questionnaire -9 by the integrated behavioral health provider as a part of clinical practice to measure treatment progress and this information will be obtained at the end of 6 months of treatment via chart review (see data sheet). Repeated measurement of patient's symptoms over the course of several months of treatment is common in clinical practice to measure patient's symptom improvement.
Study: NCT06323798

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: Standard paranasal sinus MRI

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: Standard paranasal sinus MRI
Study: NCT04846660

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Production pressure
Description: Participant exposed to production pressure
Study: NCT04734821

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Near Infra-Red Fluorescence Guided Surgery
Description: ICG injection around tumor each four direction by endoscopy followed by NIR fluorescence guidance laparoscopic or robotic esophagectomy or gastrectomy
Study: NCT05129514

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Manual Lymphatic Drainage (MLD)
Description: The participant will be placed in a supine position and manual lymphatic drainage will be performed for 50 minutes. During the three intervening days, daily 50 minute sessions of manual lymphatic drainage will be provided.
Study: NCT06018259

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: healthy volunteers blood sampling
Description: One blood sample will be taken from healthy volunteers in order to isolate PBMC and to assess the effect of the lipid of interest on them PBMC will be activated in vitro (e.g. using LPS or PHA) in the presence or absence of the lipid of interest.
Study: NCT06027411

Intervention type: DEVICE
Intervention: qER (qER EU 2.0)
Description: Qure.ai's emergency room software solution qER (qER EU 2.0) is an AI medical device, developed by training a deep-learning algorithm using over 300,000 scans labelled by expert radiologists. qER has been shown to be accurate in identifying a range of abnormalities in NCCT head scans as well as prioritising them for urgent review and radiologist reporting. It is designated as a clinical support tool and, when used with original scans, can assist the clinician to improve efficiency, accuracy, and turnaround time in reading head CTs.
Study: NCT04713618

Intervention type: PROCEDURE
Intervention: Pelvic Examination
Description: Undergo pelvic exam

Intervention type: OTHER
Intervention: Survey
Description: Complete surveys
Study: NCT06434129

Intervention type: DIAGNOSTIC_TEST
Intervention: DTI
Description: Diffusion MRI imaging

Intervention type: DIAGNOSTIC_TEST
Intervention: DTI
Description: Diffusion MRI imaging
Study: NCT04619212

Intervention type: DEVICE
Group type: OTHER
Intervention: breast pumping as per SoC but on new software for the pump
Description: breast pumping as per SoC but on new software for the pump

Intervention type: DEVICE
Group type: OTHER
Intervention: breast pumping as per SoC but on new software for the pump
Description: breast pumping as per SoC but on new software for the pump
Study: NCT06324435

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apremilast
Description: 60mg/day
Study: NCT05063032

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Radiofrecuency ablation
Description: Radiofrequency ablation to treat left atrial flutter, guided by high-density mapping versus linear ablation.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Radiofrecuency ablation
Description: Radiofrequency ablation to treat left atrial flutter, guided by high-density mapping versus linear ablation.
Study: NCT02193217

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MT-1303-Low

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: MT-1303-High

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fingolimod
Study: NCT05886608

Intervention type: DEVICE
Group type: OTHER
Intervention: AI 500™ SINGLE-DOSE GEL
Description: AI500™ SINGLE-DOSE GEL is a hydrogel to be applied to intact skin, intended to provide relief in cases of pain due to tension in muscles and adjacent tissues, to improve movement and function.
Study: NCT02193217

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Study: NCT05083065

Intervention type: BIOLOGICAL
Intervention: Covid-19 vaccine
Description: * First dose or complete cycle of Comirnaty (Pfizer/BioNTech) vaccine~* First dose or complete cycle of Spikevax (Moderna) vaccine~* First dose or complete cycle of AstraZeneca/Vaxzevria vaccine~* Complete cycle of vaccination using one type of vaccine for the first dose and a different type for the second dose~* Janssen (Johnson \& Johnson) vaccine (single dose)
Study: NCT05088811

Intervention type: DIAGNOSTIC_TEST
Intervention: WRAP53, UCA-1
Description: Diagnostic value of UCA-1 and WRAP53 in HCC

Intervention type: DIAGNOSTIC_TEST
Intervention: WRAP53, UCA-1
Description: Diagnostic value of UCA-1 and WRAP53 in HCC

Intervention type: DIAGNOSTIC_TEST
Intervention: WRAP53, UCA-1
Description: Diagnostic value of UCA-1 and WRAP53 in HCC
Study: NCT05295719

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Omega-3 polyunsaturated fatty acid
Description: 4 grams n-3 PUFA (AlaskOmega®) per day (3000 mg EPA and 1000 mg DHA)

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Omega-3 polyunsaturated fatty acid
Description: 4 grams n-3 PUFA (AlaskOmega®) per day (3000 mg EPA and 1000 mg DHA)

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: High-Intensity Interval Training
Description: A 4 x 4 high-intensity interval training (HIIT) exercise program 3 days/week for 6 weeks. This will include a 3 min warm up at 15% watt max followed by 4 intervals for 4 min at 65% watt max with 3 min active recovery at 15% watt max.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: High-Intensity Interval Training
Description: A 4 x 4 high-intensity interval training (HIIT) exercise program 3 days/week for 6 weeks. This will include a 3 min warm up at 15% watt max followed by 4 intervals for 4 min at 65% watt max with 3 min active recovery at 15% watt max.

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Safflower oil
Description: 4 grams safflower oil (AlaskOmega®) per day

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Safflower oil
Description: 4 grams safflower oil (AlaskOmega®) per day

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Flexibility training
Description: 30 min of stretching 3 days/week for 6 weeks

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Flexibility training
Description: 30 min of stretching 3 days/week for 6 weeks
Study: NCT05824936

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Pilot study arm for technology-enhanced asthma intervention
Description: Participants will be enrolled in a remote monitoring program using monthly remote study visits which will include the use of a mobile spirometer (device for testing lung function). Participants will complete monthly remote study visits visits using telehealth platform and will complete lung function testing during the visit using a mobile spirometer as well as remote study measures.
Study: NCT05451355

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Family Safety Check-In
Description: Prototype decision aid to support within-family communication and decision making about firearm storage.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: AAP Firearm Storage Web Page
Description: Educational web page that discusses safe firearm storage practices.
Study: NCT05598723

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IncobotulinumtoxinA (XEOMIN®)
Description: IncobotulinumtoxinA (XEOMIN®) is injected into specific targets at two different time points. Changes in chronic migraine frequency and duration are recorded and compared.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: OnabotulinumtoxinA (BOTOX®)
Description: OnabotulinumtoxinA (BOTOX®) is injected into specific targets at two different time points. Changes in chronic migraine frequency and duration are recorded and compared.
Study: NCT05463068

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NVX-Cov2373
Description: Intramuscular (deltoid) injection of SARS-CoV-2 rS co-formulated with Matrix-M adjuvant (0.5 mL) on Day 1

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NVX-Cov2373
Description: Intramuscular (deltoid) injection of SARS-CoV-2 rS co-formulated with Matrix-M adjuvant (0.5 mL) on Day 1

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: NVX-Cov2373
Description: Intramuscular (deltoid) injection of SARS-CoV-2 rS co-formulated with Matrix-M adjuvant (0.5 mL) on Day 1
Study: NCT05140551

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: COMPASS: digital CBT
Description: COMPASS is an evidence based digital CBT intervention with guided therapist support, tailored to treat anxiety and/or depression in long term conditions (LTCs). The intervention consists of eleven modules/sessions in which CBT techniques are taught. Users of COMPASS receive guided therapist support from a trained therapist. The guided support aims to help patients identify and apply the CBT skills outlined in COMPASS to meet their individual needs and experiences of living with LTC(s). The support can occur through in-site messaging or via the telephone.
Study: NCT05731206

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Hydrolyzed protein infant formula
Description: Hydrolyzed protein infant formula

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: commercially available hypoallergenic infant formula
Description: commercially available hypoallergenic infant formula
Study: NCT05283018

Intervention type: DEVICE
Intervention: Electroencephalogram recording
Description: Brain function monitoring using a Sedline® module (Masimo corporation) to evaluate the state of the brain under anesthesia

Intervention type: OTHER
Intervention: Auditory stimulation
Description: Monotonous sounds are sent via binaural headphones: a standard item and a distractor item (rough sound). Each stimulus lasts about 300 ms and they are separated by 1.5 to 2 seconds between them; the deviant sound/standard sound ratio is fixed between 1/5 and 1/6.

Intervention type: DEVICE
Intervention: Transcranial Doppler
Description: Measurement of cerebral blood flow velocity (CFV) with use of Transcranial Doppler ultrasonography. For all patients, CFV (unit cm/s) will be collected over four distinct periods: 1/ baseline or during pre-oxygenation at inspired oxygen fraction (FiO2) of 21% in awake patients; 2/ during anesthetic induction; 3 /deep sleep; 4/ recovery period.

Intervention type: DEVICE
Intervention: Near-infrared spectroscopy
Description: Continuous measurement of cerebral oxygen saturation (SO2) with Near-infrared spectroscopy (NIRS).~For all patients, SO2 (%) will be collected over four distinct periods: 1/ baseline or during pre-oxygenation at FiO2 of 21% in awake patients; 2/ during anesthetic induction; 3 /deep sleep; 4/ recovery period.
Study: NCT06551870

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical activity
Description: The complexity of the games will increase as the levels of the sports games advance, which leads to faster movements with greater demands to progress in the sequence of the games, which allows reaching increases in intensity.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical activity
Description: The complexity of the games will increase as the levels of the sports games advance, which leads to faster movements with greater demands to progress in the sequence of the games, which allows reaching increases in intensity.
Study: NCT04353895

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Guidance for pedicle screw insertion (Mazor Stealth)
Description: Using imaging devices and navigation for guidance, we perform a posterior vertebral fusion with pedicle screw insertion

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Guidance for pedicle screw insertion (O-arm Navigation)
Description: Using imaging devices and navigation for guidance, we perform a posterior vertebral fusion with pedicle screw insertion
Study: NCT06435910

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: DC vaccines
Description: Antigen-presenting and immune modifying DCvacs to treat MM
Study: NCT04775615

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DDO-3055 tablets；Placebo
Description: Low dose：DDO-3055 tablets for 7 days or Placebo for 7 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DDO-3055 tablets；Placebo
Description: Medium dose：DDO-3055 tablets for 7 days or Placebo for 7 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DDO-3055 tablets；Placebo
Description: High dose：DDO-3055 tablets for 7 days or Placebo for 7 days
Study: NCT04751981

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Patient Specific Guide
Description: For lumbar fusion pedicle screws will be placed with the aid of patient specific guides.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Navigation
Description: Conventional navigation will be used to place pedicle screws.
Study: NCT06435481

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 3D printed chewable formulation of hydrocortisone
Description: Administration of a novel hydrocortisone formulation provided as chewable tablets. Each tablet, manufactured with a volume dosing device (3D printer), contains a precise dosage of hydrocortisone.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oral suspension of hydrocortisone
Description: Administration of a standard hydrocortisone oral suspension. The solution, based on simple syrup, contains 1mg of hydrocortisone per milliliter.
Study: NCT05361356

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Spectral CT scanning
Description: Volunteer accept spectral CT scanning
Study: NCT05832736

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Robotic hemi-prostatectomy with urethral preservation
Description: Robotic hemi-prostatectomy with urethral preservation
Study: NCT06474039

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trelegy or Anoro
Description: Both drugs delivered via Ellipta device and blinded package appearance

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trelegy or Anoro
Description: Both drugs delivered via Ellipta device and blinded package appearance
Study: NCT05528809

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood sampling
Description: A blood sampling will be performed during the inclusion visit (day 0).

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Blood sampling
Description: A blood sampling will be performed during the inclusion visit (day 0).
Study: NCT05993455

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oral sotorasib + IV Panitumumab
Description: Oral sotorasib at a dose of 960 mg once daily with Panitumumab is administered intravenously (IV) at a dose of 6 mg/kg every 14 days, infused over 60 minutes (≤ 1,000 mg) or 90 minutes (\> 1,000 mg).