TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04527185

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Endotoxin
Description: Endotoxin 0.4ng/kg i.v.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Endotoxin
Description: Endotoxin 0.4ng/kg i.v.
Study: NCT06790368

Intervention type: BIOLOGICAL
Intervention: VENOX
Description: Treatment with allergy vaccine against Vespula spp. (wasp) or Apis mellifera (bee), as per clinical indication.
Study: NCT06791291

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Teplizumab
Description: Pharmaceutical form:Solution for injection-Route of administration:Intravenous infusion
Study: NCT06791824

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313(SC) injection
Description: Phase IB: CM313(SC) administered at low dose according to the protocol. Phase II: CM313(SC) administered at different doses based on Phase IB's results.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313(SC) injection
Description: Phase IB: CM313(SC) administered at medium dose according to the protocol. Phase II: CM313(SC) administered at different doses based on Phase IB's results.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313(SC) injection
Description: Phase IB: CM313(SC) administered at high dose according to the protocol. Phase II: CM313(SC) administered at different doses based on Phase IB's results.
Study: NCT06792019

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313(SC) injection
Description: Phase IB:CM313(SC) administered at low dose according to the protocol. Phase II:CM313(SC) administered at different doses based on Phase IB's results.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313(SC) injection
Description: Phase IB:CM313(SC) administered at medium dose according to the protocol. Phase II:CM313(SC) administered at different doses based on Phase IB's results.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313(SC) injection
Description: Phase IB:CM313(SC) administered at high dose according to the protocol. Phase II:CM313(SC) administered at different doses based on Phase IB's results.
Study: NCT06791109

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Experienced cardiologist
Description: It includes medical history collection by non-blinded independent personnel and face-to-face auscultation and evaluations conducted by specialist physicians.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: AI + Primary care doctor
Description: The study begins with non-blinded staff collecting medical histories and primary care doctors conducting face-to-face auscultations and assessments. These doctors will then use AI-equipped stethoscopes to collect heart sounds following a set protocol, uploading the recordings to a cloud platform. The AI model analyzes the data in real-time and provides an immediate diagnostic result, which is relayed back to the primary care physicians. Based on this, they will make a secondary assessment.
Study: NCT06792188

Intervention type: DEVICE
Intervention: Galaxy Watch 4, Samsung Electronics Co., Ltd., South Korea
Description: Use of the Galaxy Watch 4 during sleep for approximately two weeks prior to the polysomnography test, including the night of the test.
Study: NCT06790628

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Fibula free flap
Description: surgical technique used in reconstructive surgery where a segment of the fibula bone, along with its blood vessels, is taken from the lower leg and transplanted to reconstruct defects in the mandible due to its length, strength, and ability to support dental implants.~The blood vessels are connected to nearby vessels at the reconstruction site to ensure the bone's survival and integration.~The procedure is highly versatile and often referred to as the gold standard for mandibular reconstruction.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Fibula free flap
Description: surgical technique used in reconstructive surgery where a segment of the fibula bone, along with its blood vessels, is taken from the lower leg and transplanted to reconstruct defects in the mandible due to its length, strength, and ability to support dental implants.~The blood vessels are connected to nearby vessels at the reconstruction site to ensure the bone's survival and integration.~The procedure is highly versatile and often referred to as the gold standard for mandibular reconstruction.
Study: NCT06791447

Intervention type: OTHER
Intervention: AI-assisted Predictive Model for Dialysis Outcomes
Description: This study utilizes an AI-assisted predictive model that analyzes multimodal data from electronic health records, including medical history, laboratory results, dialysis treatment details, and clinical observations, to predict outcomes for dialysis patients. The model employs deep learning algorithms to predict mortality risk, intermediate outcomes such as anemia, blood pressure control, nutrition, and calcium-phosphate metabolism, and helps identify early signs of deterioration. The intervention is not a direct treatment or procedure but aims to develop a tool for predicting patient outcomes and optimizing treatment strategies to improve overall health and survival rates for dialysis patients.

Intervention type: OTHER
Intervention: AI-assisted Predictive Model for Dialysis Outcomes
Description: This study utilizes an AI-assisted predictive model that analyzes multimodal data from electronic health records, including medical history, laboratory results, dialysis treatment details, and clinical observations, to predict outcomes for dialysis patients. The model employs deep learning algorithms to predict mortality risk, intermediate outcomes such as anemia, blood pressure control, nutrition, and calcium-phosphate metabolism, and helps identify early signs of deterioration. The intervention is not a direct treatment or procedure but aims to develop a tool for predicting patient outcomes and optimizing treatment strategies to improve overall health and survival rates for dialysis patients.
Study: NCT06785103

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Risk assessment messaging
Description: Participants who are randomized to the HIV risk assessment arm will receive a brief video message at their baseline visit, containing information related to HIV risk assessment core concepts and encouraging them to return for a repeat HIV test. They will also receive brief SMS follow-up messages at 8 and 11 week after baseline reminding them about HIV retesting and re-emphasizing concepts from the HIV risk assessment content category.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: U=U messaging
Description: Participants who are randomized to the U=U arm will receive a brief video message at their baseline visit, containing information related to U=U core concepts and encouraging them to return for a repeat HIV test. They will also receive brief SMS follow-up messages at 8 and 11 week after baseline reminding them about HIV retesting and re-emphasizing concepts from the U=U content category.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Healthy Living messaging
Description: Participants who are randomized to the Healthy Living arm will receive a brief video message at their baseline visit, containing information related to Healthy Living core concepts and encouraging them to return for a repeat HIV test. They will also receive brief SMS follow-up messages at 8 and 11 week after baseline reminding them about HIV retesting and re-emphasizing concepts from the Healthy Living content category.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Community benefits messaging
Description: Participants who are randomized to the Community benefits arm will receive a brief video message at their baseline visit, containing information related to Community Benefits core concepts and encouraging them to return for a repeat HIV test. They will also receive brief SMS follow-up messages at 8 and 11 week after baseline reminding them about HIV retesting and re-emphasizing concepts from the Community Benefits content category.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Fresh start effect
Description: Participants who are randomized to the Fresh start effect arm will receive a brief video message at their baseline visit, containing information related to Fresh Start core concepts and encouraging them to return for a repeat HIV test. They will also receive brief SMS follow-up messages at 8 and 11 week after baseline reminding them about HIV retesting and re-emphasizing concepts from the Fresh start effect content category.
Study: NCT04408430

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transseptal ViMAC
Description: Transseptal TMVR using balloon-expandable aortic transcatheter valves.
Study: NCT06156189

Intervention type: DIETARY_SUPPLEMENT
Intervention: Enteral Feeding
Description: Feeding via Nasogastric tube in intubated and ventilated patients
Study: NCT04877886

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Ultrasound with IV contrast
Description: To compare the efficiency over the ultrasound scan within contrast

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: CT with IV contrast
Description: CT with IV contrast

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Ultrasound without IV contrast
Description: Ultrasound without IV contrast

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: CT without IV contrast
Description: CT without IV contrast
Study: NCT06791772

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313 injection
Description: CM313 600mg（4ml）/vial. Subcutaneous injection 600mg. The first 5 doses were administered weekly, followed by every two weeks, a total of 14 doses.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CM313 injection
Description: CM313 600mg（4ml）/vial. Subcutaneous injection 1200mg. The first 5 doses were administered weekly, followed by every two weeks, a total of 14 doses.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo 4 mL/vial. Subcutaneous injection 4 or 8 mL. The first 5 doses were administered weekly, followed by every two weeks, a total of 14 doses.
Study: NCT05385965

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Meaning-Centered Pain Coping Skills Training
Description: The goal of this intervention is to help participants reduce pain interference so that they can engage with what gives them a sense of meaning, purpose, and peace.
Study: NCT06789757

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Memantine Hydrochloride
Description: Memantine (5mg) is an N-methyl-D-aspartate (NMDA) receptor antagonist given in 21-day cycles over six months in combination with Bevacizumab and Atezolizumab. Each week memantine will be escalated by 5mg as tolerated

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bevacizumab
Description: Bevacizumab (15mg/kg) is a vascular endothelial growth factor inhibitor given in 21-day cycles over six months in combination with Memantine and Atezolizumab.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atezolizumab
Description: Atezolizumab (1200mg) is a programmed death-ligand 1 (PD-L1) blocking antibody given in 21-day cycles over six months in combination with Memantine and Bevacizumab
Study: NCT06791525

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tirbanibulin ointment 1%
Description: Topical application
Study: NCT06279559

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Music-therapy
Description: 10 sessions of online music therapy held by expert music therapists
Study: NCT05787470

Intervention type: BEHAVIORAL
Intervention: Quantative sensory testing
Description: All participants will undergo quantitative sensory testing for assessment of endogenous pain modulation using painful heat, mechanical, and cold stimuli in a laboratory session lasting approximately 1 hour.
Study: NCT04807101

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: midazolam alone
Description: elimination of fentanyl from conscious sedation
Study: NCT05041205

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Beauty drink powder
Description: Beauty drink powder is designed as a oral beauty product to provide benefits to skin

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Beauty drink powder
Description: Beauty drink powder is designed as a oral beauty product to provide benefits to skin

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Beauty drink powder
Description: Beauty drink powder is designed as a oral beauty product to provide benefits to skin

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Cosmetic apparatus
Description: This device is designed to let participants to experience brighter, softer, smoother skin and an energizing facial massage. A synergestic effect when combine with beauty drink powder is expected.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Cosmetic apparatus
Description: This device is designed to let participants to experience brighter, softer, smoother skin and an energizing facial massage. A synergestic effect when combine with beauty drink powder is expected.
Study: NCT05934136

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: My Healthy Brain 1
Description: My Healthy Brain 1 is an 8-week group program delivered via 90-minute Zoom meetings led by a clinical psychologist. It provides education on the link between dementia and lifestyle factors, including poor exercise, sleep, diet/nutrition, mental and social stimulation, alcohol, and smoking. My Healthy Brain 1 participants learn evidence-based mindfulness and behavior change skills to address common barriers to healthy habits, such as stress and setting achievable goals. My Healthy Brain 1 participants wear an activity watch to monitor lifestyle changes during the program.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: My Healthy Brain 2
Description: My Healthy Brain 2 condition controls for the effect of time spent and support/feedback from the group and interventionist. Participants in My Healthy Brain 2 will receive education on lifestyle, brain health, and cognitive decline symptoms in addition to usual care as determined by their medical team. Each weekly session will focus on a different topic: 1) lifestyle and brain health, 2) physical activity, 3) sleep, 4) nutrition, 5) medical adherence, 6) cognitive health, 7) social support, and 8) a program overview. My Healthy Brain 2 is conducted in the same format as My Healthy Brain 1 (8 weekly Zoom sessions, 90 minutes each), but does not include behavior change strategies. My Healthy Brain 2 participants wear an activity watch to monitor lifestyle changes during the program.
Study: NCT05045014

Intervention type: OTHER
Intervention: Balance assessment
Description: Romberg test and one-leg standing test will be used.
Study: NCT05787470

Intervention type: BEHAVIORAL
Intervention: Quantative sensory testing
Description: All participants will undergo quantitative sensory testing for assessment of endogenous pain modulation using painful heat, mechanical, and cold stimuli in a laboratory session lasting approximately 1 hour.

Intervention type: BEHAVIORAL
Intervention: Quantative sensory testing
Description: All participants will undergo quantitative sensory testing for assessment of endogenous pain modulation using painful heat, mechanical, and cold stimuli in a laboratory session lasting approximately 1 hour.

Intervention type: BEHAVIORAL
Intervention: Quantative sensory testing
Description: All participants will undergo quantitative sensory testing for assessment of endogenous pain modulation using painful heat, mechanical, and cold stimuli in a laboratory session lasting approximately 1 hour.

Intervention type: BEHAVIORAL
Intervention: Quantative sensory testing
Description: All participants will undergo quantitative sensory testing for assessment of endogenous pain modulation using painful heat, mechanical, and cold stimuli in a laboratory session lasting approximately 1 hour.

Intervention type: BEHAVIORAL
Intervention: Quantative sensory testing
Description: All participants will undergo quantitative sensory testing for assessment of endogenous pain modulation using painful heat, mechanical, and cold stimuli in a laboratory session lasting approximately 1 hour.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Draw
Description: Sample of blood will be taken.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Draw
Description: Sample of blood will be taken.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Draw
Description: Sample of blood will be taken.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Draw
Description: Sample of blood will be taken.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Draw
Description: Sample of blood will be taken.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Draw
Description: Sample of blood will be taken.
Study: NCT04220931

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: botulinum toxin injection
Description: injection of Botulinum toxin A 100 UI, single dose administration, in the major papilla, in the Oddi sphincter, during upper gastrointestinal endoscopy.
Study: NCT06633718

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Meropenem and Pralurbactam
Description: 3g，q8h，120min infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Saline
Description: 100mL，q8h，60min infusion

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ceftazidime-avibactam
Description: 2.5g，q8h，120min infusion

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Metronidazole
Description: 0.915g，q8h，60min infusion
Study: NCT05919121

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Therapeutic exercise
Description: 1. Stretching exercise of posterior shoulder capsule~2. Strengthening exercises: consists of 6 strengthening exercises all of which have been recommended as essential for any shoulder rehabilitation program.~3. The remaining 2 exercises are the seated press-up and the elbow push up. Both will be performed to fatigue or for a maximum of 25 repetitions. The quality of all repetitions of each exercise will continuously monitored by the investigator of the study

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Therapeutic exercise
Description: 1. Stretching exercise of posterior shoulder capsule~2. Strengthening exercises: consists of 6 strengthening exercises all of which have been recommended as essential for any shoulder rehabilitation program.~3. The remaining 2 exercises are the seated press-up and the elbow push up. Both will be performed to fatigue or for a maximum of 25 repetitions. The quality of all repetitions of each exercise will continuously monitored by the investigator of the study

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Therapeutic exercise
Description: 1. Stretching exercise of posterior shoulder capsule~2. Strengthening exercises: consists of 6 strengthening exercises all of which have been recommended as essential for any shoulder rehabilitation program.~3. The remaining 2 exercises are the seated press-up and the elbow push up. Both will be performed to fatigue or for a maximum of 25 repetitions. The quality of all repetitions of each exercise will continuously monitored by the investigator of the study

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: hydrocortisone phonophoresis
Description: In this study, the effective area of radiation (ERA) in the mode continuous (100 percent) is 5 cm2, in 1 MHz and 0.7 W/cm2, with four ERA treated areas. Therapy lasted five minutes (three minutes in the insertion of the supraspinatus and 37 two minutes in the infraspinatus insertion) three times weekly over 6 weeks in addition to therapeutic exercises

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: hydrocortisone iontophoresis
Description: A direct current electrical stimulation unit will be used to apply iontophoresis. The unit has two electrodes; one electrode is for the negative current, and one is for the positive current. The Active (Negative) electrode will be placed on the anterolateral aspect of the shoulder joint. The passive electrode: will be placed on the upper arm region. Intensity of the current: Between the range of 3-5 mA at the point of sensation of patient was set. Treatment duration: Calculated accordingly with intensity of current. Method of application: hydrocortisone gel 10% will be administered by applying on the active rubber electrode for each session three times weekly over 6 weeks in addition to therapeutic exercises.
Study: NCT05567120

Intervention type: OTHER
Group type: OTHER
Intervention: PATH-Care
Description: Individuals will receive the 8-session PATH-Care intervention, delivered virtually (via videoconference or phone) to mitigate negative emotions and stress experienced by informal caregivers of individuals with ADRD. The therapist in the first session will also guide the participant in the tablet-based exercises (WELLPath).
Study: NCT05898321

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Zoladex
Description: Patients with fibroid remained will be enrolled and divided into three groups. one group wii be administrated with Zoladex (3.60mg/28 days) for three to six months.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mifepristone Oral Tablet
Description: Patients with fibroid remained will be enrolled and divided into three groups. one group will be administrated with mifepristone(10.0mg/d) for three to six months.
Study: NCT03451487

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Panadol®
Description: Acetaminophen 500mg Tablet

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Panadol®
Description: Acetaminophen 500mg Tablet
Study: NCT04864470

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stroke Odysseys
Description: The participants will take part in a twelve-week performance programme that takes place online/in a community halls/arts centre. Sessions run for three hours and during these sessions, participants devise a dance and music performance work from their own stories. The culmination of the programme will be a public facing performance to an audience of carers, health care practitioners, friends, family and the wider community, done online through Zoom.~After the performance is completed, participants will be invited to a training programme where they learn to act as advocates for life after stroke - termed 'stroke ambassadors'. The training will be a four-day programme. The programme will take place once weekly and is led by a team of artists supported by a leadership coach, on Zoom.~Following training, ambassadors will support artists in recruitment, befriend the newly discharged stroke survivors and take part in small scale performance tours to challenge the perception of disability.
Study: NCT05182255

Intervention type: DEVICE
Intervention: Evolution® Esophageal Stent Systems, Europe: Fully and Partially Covered
Description: To aid in maintaining patency of the esophagus in cases of obstruction of the esophagus caused by an esophageal disease and to seal tracheoesophageal fistula.