Study: NCT06616363

Intervention type: DIAGNOSTIC_TEST
Intervention: A fMRI scan
Description: • Participants will complete a fMRI scan without contrast and complete a looming animacy threat task; participants judge the valence of images via button press as they perceive the image.

Intervention type: DIAGNOSTIC_TEST
Intervention: A bedside tilt test will be performed
Description: A bedside tilt test will be performed where blood pressure will be recorded supine and upright positions to confirm/exclude POTS.

Intervention type: DIAGNOSTIC_TEST
Intervention: A bedside tilt test will be performed
Description: A bedside tilt test will be performed where blood pressure will be recorded supine and upright positions to confirm/exclude POTS.

Intervention type: DIAGNOSTIC_TEST
Intervention: A bedside tilt test will be performed
Description: A bedside tilt test will be performed where blood pressure will be recorded supine and upright positions to confirm/exclude POTS.

Intervention type: OTHER
Intervention: IV placed to collect blood samples
Description: • An IV will be place for collection of 4 blood samples, about 12 mL of blood. For each position (lying and standing) the study team will draw 2 tubes each times with 3 mL of blood, for a total of 4 lab tubes (12 mL). Physical exams to assess the 18-tender points described by the American College of Rheumatology for the diagnosis of fibromyalgia and hypermobility/Ehlers-Danlos Syndrome (EDS) exam will be performed in all subjects.

Intervention type: OTHER
Intervention: IV placed to collect blood samples
Description: • An IV will be place for collection of 4 blood samples, about 12 mL of blood. For each position (lying and standing) the study team will draw 2 tubes each times with 3 mL of blood, for a total of 4 lab tubes (12 mL). Physical exams to assess the 18-tender points described by the American College of Rheumatology for the diagnosis of fibromyalgia and hypermobility/Ehlers-Danlos Syndrome (EDS) exam will be performed in all subjects.

Intervention type: OTHER
Intervention: IV placed to collect blood samples
Description: • An IV will be place for collection of 4 blood samples, about 12 mL of blood. For each position (lying and standing) the study team will draw 2 tubes each times with 3 mL of blood, for a total of 4 lab tubes (12 mL). Physical exams to assess the 18-tender points described by the American College of Rheumatology for the diagnosis of fibromyalgia and hypermobility/Ehlers-Danlos Syndrome (EDS) exam will be performed in all subjects.

Intervention type: OTHER
Intervention: Stool Sample
Description: • Participants will provide a stool biospecimen sample at each in-person visit. Stool will be collected in a hat and sample will be swabbed with the swab placed directly into PrimeStore collection tube and the remainder of the sample discarded

Intervention type: OTHER
Intervention: Stool Sample
Description: • Participants will provide a stool biospecimen sample at each in-person visit. Stool will be collected in a hat and sample will be swabbed with the swab placed directly into PrimeStore collection tube and the remainder of the sample discarded

Intervention type: OTHER
Intervention: Stool Sample
Description: • Participants will provide a stool biospecimen sample at each in-person visit. Stool will be collected in a hat and sample will be swabbed with the swab placed directly into PrimeStore collection tube and the remainder of the sample discarded