TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05603065

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tislelizumab + cisplatin + paclitaxel
Description: Tislelizumab 200mgD1 + cisplatin 75mg/m\^2D1 + paclitaxel 150mg/m\^2D1 Q3W 3 cycles

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tislelizumab + radiotherapy
Description: Tislelizumab 200mgQ3W 3 cycles + radiotherapy (23 times in total, 1.8 Gy per dose, 5 times a week)
Study: NCT05623371

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Training leaders in leading well-being and the psychosocial working environment
Description: The intervention comprises five training modules with practice in small groups in between. Training will take place over 5 months. The training will be received in groups of 20 and the training will be facilitated by 2 facilitators. Central themes of the training are:~1. Self-care and well-being of the manager and how to cope with stress as a manager.~2. Employee well-being and reducing risk-factors in the psychosocial working environment of employee mental health problems~3. Enhancing protective factors social social support and a healthy team climate~4. Responding to employees at risk and how to handle difficult conversations and procedures on return to work~5. Managing well-being in employees during organizational change and final reflections~The training will comprise video material and in person training of competencies and behaviors in group settings.~The waitlist control group will receive an offer of a webinar and written information.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: The offer of a webinar and written material
Description: The offer of a webinar plus written material
Study: NCT06325345

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Gut-directed hypnotherapy
Description: Eight session gut-directed hypnotherapy for IBS symptoms adapted from the evidence-based Manchester protocol for treatment of IBS.

Intervention type: OTHER
Group type: OTHER
Intervention: Standard Medical Therapy
Description: Standard medical treatment will be administered by board certified gastroenterologists

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard Medical Therapy
Description: Standard medical treatment will be administered by board certified gastroenterologists
Study: NCT05765747

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Yunnan Baiyao
Description: Yunnan Baiyao group will be given 4 times a day, 2 capsules each time after morning, afternoon and evening meals and before going to bed. One capsule of Baoxianzi will be provided for the first time to be taken at the same time with Yunnan Baiyao Capsule, which will be given continuously for 2 weeks.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Celecoxib 200mg
Description: The celecoxib group will be given 1 capsule twice a day after breakfast and dinner for 2 weeks.
Study: NCT05020704

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Empagliflozin 10 MG
Description: SGLT2inhibitor

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Matched placebo
Study: NCT05207085

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Valbenazine Oral Capsule
Description: Participants randomized to active treatment will be given a starting dose of 40mg of valbenazine , which may be escalated to 80mg to achieve an optimal dose of the medication for each subject.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Oral capsule
Description: Participants randomized to placebo will be given a capsule that is the same shape and color as the active medication and will subject to the same dose escalation requirements as the other arm but will receive placebo during the treatment period.
Study: NCT05889208

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Prophylactic pacemaker implantation
Description: Pacemaker implantation prior the TAVI-procedure
Study: NCT04889352

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Access to colonoscopy web app
Description: There is a very high utilization of colonoscopy at both shorter and longer time intervals than the recommended guidelines. Investigators have developed a clinical support tool in which the characteristics of the patients can be inputted and the guideline recommended time interval for surveillance colonoscopy is then provided. This tool uses the recommendations from the current North American national guidelines. The tool has been developed as a web-based application as well as a smart phone application.
Study: NCT06504524

Intervention type: DRUG
Intervention: Elranatamab
Description: BCMA-CD3 bispecific antibody

Intervention type: DRUG
Intervention: Standard of Care
Description: control arm
Study: NCT06432946

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Video
Description: A 7-minute video demonstrating the sensing-glove system, how it can be used to assess manual therapy biomechanics, and its relevance in research and clinical contexts. The video was created by the research team via a voiceover PowerPoint presentation.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Video
Description: A 7-minute video demonstrating the sensing-glove system, how it can be used to assess manual therapy biomechanics, and its relevance in research and clinical contexts. The video was created by the research team via a voiceover PowerPoint presentation.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Practice session
Description: A 20-minute practice session during which participants received verbal information about the sensing-glove system. While wearing the sensing glove, participants performed palpation and manual therapy techniques (palpation, spinal mobilization/manipulation to the cervical and thoracic spine) on a human-sized manikin, guided by the researcher.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Practice session
Description: A 20-minute practice session during which participants received verbal information about the sensing-glove system. While wearing the sensing glove, participants performed palpation and manual therapy techniques (palpation, spinal mobilization/manipulation to the cervical and thoracic spine) on a human-sized manikin, guided by the researcher.
Study: NCT06528171

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Brain MRI
Description: non injected brain MRI

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Brain MRI
Description: non injected brain MRI

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: Specific blood samples
Description: blood samples to find immunological and inflammatory markers

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: Specific blood samples
Description: blood samples to find immunological and inflammatory markers
Study: NCT05230199

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: SENSE multisensory program
Description: In order to support parent's ability to implement the daily SENSE program they will be provided with an educational manual reviewing the program, weekly meetings with a therapist, and logs to report their visitation schedule and activities. Parents are able to choose different types of each sensory exposure. All options address the same key principles for that behavior and only include those that have evidence to support their use and are appropriate at each PMA.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Monitored standard of care
Description: Infants who receive sensory exposures only as standard of care but do not recieve the SENSE program
Study: NCT06141421

Intervention type: PROCEDURE
Intervention: procedure
Description: procedure
Study: NCT05547776

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Mindfulness app
Description: The mindfulness app contains 6 modules with a variety of features to help caregivers reduce their stress.
Study: NCT06088368

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: in-plane needle guidance
Description: Ultrasound -guided lumbar plexus block with in-plane needle guidance using the Shamrock method

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: out-of-plane needle guidance
Description: Ultrasound -guided lumbar plexus block with out-of-plane needle guidance using Shamrock method
Study: NCT05666817

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: breastfeeding education
Description: Mothers in the intervention group will be given breastfeeding training after the pre-test application. The content of breastfeeding education is as follows;~* General information about breastfeeding,~* General information about breast milk and the benefits of breast milk,~* Benefits of breastfeeding for mother and baby,~* How the baby should be held during breastfeeding, the baby's position,~* Effective breastfeeding positions for the mother,~* Ensuring that the baby holds the breast correctly,~* Providing the correct breastfeeding technique,~* Breast milking and storage conditions,~* The necessity and benefits of continuing breastfeeding.
Study: NCT06101472

Intervention type: DEVICE
Intervention: ASQELIO Toric Biaspheric Monofocal Lens
Description: Intraocular lens implantation in cataract surgery
Study: NCT04908475

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Risankizumab
Description: Subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Risankizumab
Description: Subcutaneous injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apremilast
Description: Oral Tablets
Study: NCT05628298

Intervention type: DEVICE
Intervention: Soovu Pain Relief System
Description: The Soovu Pain Relief system uses pulses of heat to block the TRPV-1 calcium channel on peripheral pain nerves. The study will determine if the FDA cleared device significantly reduces the subject's pregnancy related pain.
Study: NCT04638803

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PRX-P4-003, (-)-FCF
Description: sequential study

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PRX-P4-003, (-)-FCF
Description: sequential study
Study: NCT05739110

Intervention type: BEHAVIORAL
Intervention: tumor micronecrosis
Description: whether HCC patients have tumor micronecrosis or not
Study: NCT06054919

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cholecalciferol
Description: vitamin D3

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cholecalciferol
Description: vitamin D3
Study: NCT04745936

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Style curve similar to natural curvature of endotracheal tube
Description: Stylet curvature is made similar to the natural curvature of endotracheal tube for intubation using C-MAC videolaryngoscope.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Style curve similar to hockey stick shape
Description: Stylet curvature is made similar to hockey stick shape for intubation using C-MAC videolaryngoscope.
Study: NCT05072262

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Nepafenac Ophthalmic
Description: Topical nepafenac (Nevanac) 3 mg/ml

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone Ophthalmic
Description: Topical dexamethasone 1 mg/ml (Spersadex)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone Ophthalmic
Description: Topical dexamethasone 1 mg/ml (Spersadex)
Study: NCT05913596

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Daratumumab
Description: After successful enrollment, the patient will receive daratumumab of 16mg/kg once every two weeks (0-22 weeks) for a total of 12 times. Peripheral blood samples were collected from 0 to 24 weeks (weeks 0, 2, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, and 24) for routine blood tests, liver and kidney function electrolytes, tacrolimus or cyclosporine trough concentrations, HLA antibody quantification (weeks 0, 4, 8, 12, 16, 20, and 24), infection indicators (weeks 0, 8, and 24), immune status assessments (weeks 0, 4, 8, 12, 16, 20, and 24), and biopsy of transplanted kidneys was performed at 24 weeks to assess pathological changes.
Study: NCT04939454

Intervention type: PROCEDURE
Group type: OTHER
Intervention: quadricipital biopsy
Description: The primary endpoint will be evaluated by histological examination only. The technique of percutaneous biopsy using the modified Bergström needle technique is currently considered the best alternative in the context of research, as it allows sufficient material to be obtained for various analyses and is much less invasive than the reference technique (surgical biopsy). Indeed, unlike surgical biopsy which requires an operating room and is a relatively heavy procedure (two suture planes, skin incision of several centimeters, resting for 48 hours after the procedure...), percutaneous biopsy by the modified Bergström technique can be performed in a consultation room, requires only one stitch, and allows resumption of walking 30 minutes after the end of the procedure.
Study: NCT05964959

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mouth Educational Program
Description: The Mouth Educational Program is a nurse-led patient education program for dry mouth in patients with a life-limiting condition or frailty.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Care as Usual
Description: Care as usual is defined as the standard dry mouth care as provided by participants' own treating physicians.
Study: NCT04939454

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: quadricipital biopsy
Description: The primary endpoint will be evaluated by histological examination only. The technique of percutaneous biopsy using the modified Bergström needle technique is currently considered the best alternative in the context of research, as it allows sufficient material to be obtained for various analyses and is much less invasive than the reference technique (surgical biopsy). Indeed, unlike surgical biopsy which requires an operating room and is a relatively heavy procedure (two suture planes, skin incision of several centimeters, resting for 48 hours after the procedure...), percutaneous biopsy by the modified Bergström technique can be performed in a consultation room, requires only one stitch, and allows resumption of walking 30 minutes after the end of the procedure.
Study: NCT06229899

Intervention type: DIAGNOSTIC_TEST
Intervention: Serum follistatin levels
Description: blood samples are taken

Intervention type: DIAGNOSTIC_TEST
Intervention: Serum follistatin levels
Description: blood samples are taken
Study: NCT05619770

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 101-PGC-005
Description: Bolus Injection containing 30mg of 101-PGC-005 will administered intravenously once daily for 3 consecutive days
Study: NCT06118450

Intervention type: OTHER
Intervention: Non-intervention
Description: non-intervention

Intervention type: OTHER
Intervention: Non-intervention
Description: non-intervention
Study: NCT06311526

Intervention type: OTHER
Intervention: Extracorporeal Shockwave Therapy
Description: Extracorporeal Shockwave Therapy administered to the belly of spastic muscles of the upper limb.
Study: NCT06276205

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vitamin D
Description: if Vitamin D level suboptimal, 50,000 IU/week for 8 weeks followed by 2000 IU/d~if optimal Vitamin D level, 2000 IU/d

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levothyroxin
Description: commenced at a dose of 1.6mcg/kg/day and will be titrated 8 weekly according to response

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Levothyroxin
Description: commenced at a dose of 1.6mcg/kg/day and will be titrated 8 weekly according to response
Study: NCT05961982

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Chemical Ablation
Description: Undergo EUS-guided chemoablation

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Computed Tomography
Description: Undergo CT

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Electronic Health Record Review
Description: Ancillary studies

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endoscopic Ultrasound-Guided Fine-Needle Aspiration
Description: Undergo EUS-FNA

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Endoscopic Ultrasound-Guided Radiofrequency Ablation
Description: Undergo EUS-RFA

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Cholangiopancreatography
Description: Undergo MRI/MRCP

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Undergo MRI/MRCP
Study: NCT05689281

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Peer PrEP Navigation
Description: Ecological momentary assessments to identify and address stressors related to social determinants of health (e.g., housing, substance use, mental health), and motivational interviewing to support participants' health care empowerment and progression along the PrEP continuum.
Study: NCT05167032

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Multisensory Rehabilitation (CMR)
Description: The goal of CMR is to restore proprioception (i.e., sense of joint position and movement), body awareness, and awareness of the paralyzed limbs and trunk in space, in order to improve sensory and motor function. For example, CMR tasks will have the participant solve exercises related to: (i) where the legs are situated in space; where the legs are in relation to the pelvis and the upper part of the body (ii) the dimensions and length of the legs, the dimension of the pelvis, and sensation of the pelvis as a central body reference. (iii) the relationship between the left and right side of the body, and the relationship between the pelvis and the feet. Further, improvements in touch and pressure sensation are obtained with (v) texture discrimination tasks, and (vi) discrimination of sponges with varying resistance. Given the importance of sensory feedback for movement, sensory improvements create the opportunity for motor recovery to occur.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Adaptive fitness
Description: The Courage Kenny Rehabilitation Institute centers provide access to state-of- the-art adaptive gym equipment in their fitness center to promote fitness and recreation. Equipment includes treadmills, elliptical, NuSteps, SciFit upper body ergometers, Ski Erg and Rowing Machine, Upright and recumbent stationary bicycles, chest press, rear row, leg extension, leg curl, leg press, uppertone, free weights, and kettlebells. The equipment is spaced to allow for movement and is accessible for use from a wheelchair. They allow for transfers and caregiver assistance.
Study: NCT05777941

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: eccentric arm-cranking training
Description: Over the twenty training sessions, able-bodied participants will exercise on the KREHA device. An arm-crank has to be decelerated, which will be rotated by a prematurely defined revolution rate and training duration. During this intervention a certain power has to be applied. During the whole time of training a continous progression in power and training duration is applied.
Study: NCT06197308

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: oral vancomycin and oral amoxicillin
Description: In this study, PSC patients will receive an antibiotic preconditioning regimen of oral vancomycin (500 mg liquid twice a day) for 28 days and oral amoxicillin (1000 mg twice a day) for 7 days (during the last 7 days of the oral vancomycin). Following vancomycin and amoxicillin, encapsulated, freeze-dried microbiota preparation (MTP-101C) will be administered - dosed at ≥ 5 x 10\^11 bacteria (five capsules) daily for 3 days followed by ≥ 2 x 10\^11 bacteria (two capsules) for 11 days - for a total of 14 days of MTP-101C; total of 37 capsules.
Study: NCT03949465

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial Magnetic Stimulator
Description: Repetitive Transcranial magnetic stimulation (rTMS) will be delivered using a MagPro X100 device with B70 coil and the intermittent theta burst (iTBS) protocol to the left dorsolateral prefrontal cortex. Participants will receive daily treatments (Monday-Friday) over four weeks
Study: NCT05095311

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cetirizine HCl
Description: Eight participants will be administered 10 mg of cetirizine HCl to examine whether this drug can improve their oxyhemoglobin saturation during exercise.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: The placebo pill is a sugar-free gelatin pill casing. The placebo inhaler contains isotonic saline.
Study: NCT06145529

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: RT Functional HIIT circuit program (15 minutes) with or without gamification approach
Description: EG1 (RT Functional HIIT circuit program): This intervention involves a 15-minute Resistance Training (RT) Functional High-Intensity Interval Training (HIIT) circuit program. The focus is on functional movements performed at a high intensity within intervals.~EG2 (RT Functional HIIT circuit program with gamification): This intervention replicates the RT Functional HIIT circuit program from EG1 but incorporates gamification strategies. Gamification involves the application of game-like elements, such as points, rewards, and competition, to make the exercise routine more engaging and enjoyable for the participants.~Control Group (CG): Children in the control group continue with their regular Physical Education (PE) sessions, maintaining their usual routine

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: RT Functional HIIT circuit program (15 minutes) with or without gamification approach
Description: EG1 (RT Functional HIIT circuit program): This intervention involves a 15-minute Resistance Training (RT) Functional High-Intensity Interval Training (HIIT) circuit program. The focus is on functional movements performed at a high intensity within intervals.~EG2 (RT Functional HIIT circuit program with gamification): This intervention replicates the RT Functional HIIT circuit program from EG1 but incorporates gamification strategies. Gamification involves the application of game-like elements, such as points, rewards, and competition, to make the exercise routine more engaging and enjoyable for the participants.~Control Group (CG): Children in the control group continue with their regular Physical Education (PE) sessions, maintaining their usual routine
Study: NCT06730269

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Face-to-Face Rehabilitation Program
Description: The Face-to-Face Rehabilitation Program is a structured rehabilitation regimen designed to improve posture, reduce pain, and strengthen back extensor muscles in children with thoracic hyperkyphosis. Participants in this group engaged in the Thoracic Corrective Exercise Program, which included four specific exercises targeting thoracic spine correction. The exercises were performed three times per week over six weeks, under the direct supervision of a trained therapist. This setup ensured real-time feedback, personalized adjustments, and guidance during each session, optimizing the effectiveness of the rehabilitation process.