TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05992805

Intervention type: OTHER
Intervention: N/A - non-interventional study
Description: N/A - non-interventional study. Data collection only.
Study: NCT05631912

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Autologous CD19-STAR-T cell
Description: Phase 1 dose escalation (3+3) : dose 1 (1×10\^6 cells/kg) ,dose 2 (3×10\^6 cells/kg) ,dose 3 (1×10\^7 cells/kg); Phase 2 : Appropriate dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: Intravenous fludarabine 25-30 mg/m\^2/day on days -5, -4, and -3.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Intravenous cyclophosphamide 300-500 mg/m\^2/day on days -5, -4, and -3.
Study: NCT05709808

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesio-taping
Description: kinesiotape is a method of taping used to improve support and increase proprioceptive awareness of the joint, while the exercise program was designed to improve postural stability and balance

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Kinesio-taping
Description: kinesiotape is a method of taping used to improve support and increase proprioceptive awareness of the joint, while the exercise program was designed to improve postural stability and balance

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: exercises
Description: A standard proprioceptive training program will be implemented three times a week. The training includes both static and dynamic balance on Wobble board with the eyes open while the last stage will be repeated with the eyes closed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: exercises
Description: A standard proprioceptive training program will be implemented three times a week. The training includes both static and dynamic balance on Wobble board with the eyes open while the last stage will be repeated with the eyes closed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mixed kinesiotape plus exercises
Description: kinesiotape is a method of taping used to improve support and increase proprioceptive awareness of the joint, while the exercise program was designed to improve postural stability and balance. A standard proprioceptive training program will be implemented three times a week. The training includes both static and dynamic balance on Wobble board with the eyes open while the last stage will be repeated with the eyes closed.
Study: NCT05910229

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Phone call
Description: In the experimental arm the patient will be called 3 days before the CT scan
Study: NCT05874531

Intervention type: DIAGNOSTIC_TEST
Intervention: End-expiratory occlusion test
Description: 15 seconds end-expiratory occlusion

Intervention type: DIAGNOSTIC_TEST
Intervention: End-expiratory occlusion test
Description: 15 seconds end-expiratory occlusion
Study: NCT06454084

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Acetylcholine Chloride
Description: Vasodilator solution
Study: NCT05384041

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Fisher Wallace Cranial Electrotherapy Stimulator (Active Device)
Description: The indicated use in adults (ages 21-65 years) is for 20 minutes twice daily, upon waking for the day and at bedtime. The treatment period of the intervention will have a duration of four weeks.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Fisher Wallace Cranial Electrotherapy Stimulator (Placebo Device)
Description: The placebo device is designed to provide exactly the same patient experience as the active device; however, the placebo device will not deliver the same frequencies as the active device. The placebo device will provide no therapeutic benefit.
Study: NCT06128811

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Rubber Dam Isolation
Description: Rubber dam isolation will be placed using a proper size dental clamp on the first permanent molar after topical anesthesia application.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Rubber Dam Isolation
Description: Rubber dam isolation will be placed using a proper size dental clamp on the first permanent molar after topical anesthesia application.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: DryShieled isolation
Description: For the DryShieled isolation, a pedo-size mouthpiece will be utilized with all the participants.
Study: NCT04539093

Intervention type: OTHER
Intervention: Exposure of interest - Use of left ventricular assist device (LVAD)
Description: Mechanical circulatory support devices such as left ventricular assist device is used as a treatment option for patients with end-stage heart failure.
Study: NCT05728788

Intervention type: DRUG
Intervention: Antitumor drugs
Description: Anthracyclines, immune checkpoint inhibitors, monoclonal antibodies, and tyrosine kinase inhibitors
Study: NCT06128811

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: DryShieled isolation
Description: For the DryShieled isolation, a pedo-size mouthpiece will be utilized with all the participants.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: fissure sealant
Description: After proper isolation, fissure sealant (Conseal-F TM SDI) will be applied following the manufacturer's instructions, and the quality of the applied fissure sealant will be checked with an explorer. An additional layer will be applied if any deficiency is detected

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: fissure sealant
Description: After proper isolation, fissure sealant (Conseal-F TM SDI) will be applied following the manufacturer's instructions, and the quality of the applied fissure sealant will be checked with an explorer. An additional layer will be applied if any deficiency is detected
Study: NCT04766281

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: MLC901
Description: This consists of extracts from 9 herbal components in a dark blue/light blue capsule

Intervention type: GENETIC
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: This consists of a dark brown powder in size 0 dark blue/light blue vegetable capsule
Study: NCT05353790

Intervention type: OTHER
Group type: OTHER
Intervention: Meals + snacks: control
Description: 8 weeks meal plans matched in calories (but not macronutrients or fiber) equivalent to 1 avocado + 1 cup of mango per day

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Meals + snacks: Avocado mango
Description: 8 weeks meal plans provide1 avocado + 1 cup of mango per day
Study: NCT06242119

Intervention type: DIAGNOSTIC_TEST
Intervention: J-PET scan
Description: Diagnostic Test: Positron-Emission Tomography Imaging Examination of radiation distribution in the patient body after completing a routine examination on a PET diagnostic device. J-PET prototype tests will be carried out in patients who have undergone a classic PET examination after administration of \[18F\]FDG), \[68Ga\]Ga-PSMA, \[18F\]choline or \[68Ga\]Ga-DOTATATE). The duration of the additional exam will be approximately 20 minutes.
Study: NCT04118283

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Cognitive Behavioral Therapy for Chronic Pain
Description: Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) will be conducted in accordance with the Cognitive Behavioral Therapy for Chronic Pain: Therapist Manual and the VA Evidence-Based Practice (EBP) roll-out training. CBT-CP consists of a 12-session protocol, including an initial assessment session (BL assessment; Session 1), 10 content-specific sessions (pain education, goal-setting, cognitive and behavioral skill building; Sessions 2-11), and a booster session scheduled approximately one month after the final CBT-CP session (Session 12). Participants randomized to the CBT-CP condition (n = 30) will complete one 60-minute individual session per week. Each CBT-CP session will be led by a trained study interventionist using a manualized curriculum, following a basic structure including review of previous session material, introduction of new information or skills, and discussion of how to implement learned material into a home action plan.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Health and Wellness
Description: Health \& Wellness was developed by VISN 5 MIRECC investigators and consists of psychoeducation on topics related to physical and emotional wellbeing. Its structure is similar to CBT-CP (10 weekly individual 60-minute sessions, no booster session). Each Health \& Wellness session will be led by a trained interventionist using a manualized curriculum that includes review of previous session material, introduction of new information, and discussion of a range of health-related topics (physical activity/exercise, nutrition/healthy eating, managing medications and side effects, and addictive behaviors (e.g., substance use, gambling, eating) that do not include pain. Typical sessions include discussion of the impact of the topic on overall health and well-being, identifying benefits and challenges to improving or maintaining health in that area, and strategies to address challenges in that area.
Study: NCT04551040

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Terazosin
Description: Terazosin 1 mg oral capsule
Study: NCT06313892

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Home based Exercise
Description: The participants in the study group will be given an online personalized exercise program at home in non dialysis days. Synchronous tele-exercise will be delivered using the free teleconference application (app) (Google Meets software). The groups of tele-exercises will be private and the professional will send the link for each training session and will control the access of the participants. Each session will be 40 to 45 min in duration for 3 days per week over 12 weeks, 36 sessions in total.
Study: NCT05676203

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Standard ADT (androgen deprivation therapy)
Description: as prescribed by the treating physician.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard ADT (androgen deprivation therapy)
Description: as prescribed by the treating physician.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Standard Darolutamide
Description: 2x600 mg/d as prescribed by the treating physician

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard Darolutamide
Description: 2x600 mg/d as prescribed by the treating physician

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Docetaxel
Description: Docetaxel

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Docetaxel
Description: Docetaxel
Study: NCT05503771

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ISA-MI
Description: Parents seen by clinicians randomized to the intervention group will complete the Infant Sleep Assessment (ISA), either prior to their visit using MyChart (Epic patient portal) or on a tablet computer in the exam room while they wait for their clinician; 2) a Clinical Decision Support (CDS) smart form is created in the EMR based on the assessment results, with risks and MI-informed strategies highlighted; this information will be derived from a pre-programmed algorithm and theory-based, tailored communication strategies and messages; 3) the clinician uses the CDS smart form to guide counseling with the parent during the visit, applying their training in MI-informed counseling skills; and 4) Clinician gives the parent an After Visit Summary (AVS) from the EMR (or informs them that they can access the AVS in MyChart if the parent or other caregivers use the patient portal, MyChart), which summarizes and reinforces the safe sleep counseling.

Intervention type: OTHER
Group type: OTHER
Intervention: Standard of Care (SOC)
Description: Parents seen by clinicians randomized to the control group will receive the usual practice that pediatric residents are taught which follows the American Academy of Pediatrics (AAP) Bright Futures Health Supervision Guidelines and includes age and developmentally based anticipatory guidance. As part of their training, residents receive formal teaching on core aspects of providing primary care to infants, including the AAP recommendations on safe sleep. This includes the recommended ABCS: babies should sleep Alone (no objects or people), on their Back (supine), in a Crib (or safe alternative including portable crib or bassinet), and in a Smoke-free environment.
Study: NCT06542575

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: DTx-guided HBCR
Description: The Huaxiaoxin WeChat mini program incorporating the core components of guidelines are divided into two main sections. Section 1 comprises interventions such as exercise training, educational programmes and cardiovascular risk factor management. Section 2 provides a secure platform for individualized feedback, just-in-time two-way communication, remote data transmission, and data repository, allowing patients and healthcare providers to access all relevant files anytime and anywhere throughout the 12-month study period.
Study: NCT05551637

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Kazu Gain Gold
Description: Kazu Gain Gold is an Oral Nutritional Supplementation made by AIWAIDO Food Joint Stock Company.~Condition: Powder~Color: White to light yellow~Scent: The fresh scent of milk, gracious sugary smell.~Date of use: 24 months from the manufactured date.~User Manual: Mix 6 spoons of Kazu Gain Gold (equal to 49,2 grams) with 180 ml of warm water (The energy density reaches 1kal/ml). Consume 2 glasses per day or follow the directions from the medical staff. The product should consume less than 1 hour. Do not let the child eat the leftovers of the previous meal.~Preserve: Store in a clean, dry place, and keep away from direct sunlight. Opened can or package must be closed and used up within 3 weeks.
Study: NCT05251129

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atorvastatin 80 Mg Oral Tablet
Description: Higher intensity statin

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pravastatin 40 Mg Oral Tablet
Description: Lower intensity statin
Study: NCT05375279

Intervention type: PROCEDURE
Intervention: Lip Salivary Gland Biopsy
Description: Obtaining few salivary glands from the partipants' lip that will be studied using the Congo Red staining method.
Study: NCT05542108

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Multisensory Stimulation and Family Education Group
Description: Bedside intervention directly with infant with trained healthcare providers and parents. Includes two parts: twice daily multisensory stimulation sessions and separate family education meetings completed with individual infant parent/s and trained operator.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Family Education Only Group (FEG)
Description: Bedside intervention directly with infant with trained healthcare providers and parents. Includes family education meetings completed with individual infant parent/s and trained operator.
Study: NCT06366906

Intervention type: DIAGNOSTIC_TEST
Intervention: The Resnet50 deep learning (DL) model
Description: The predictive capability of the above Resnet50 deep learning (DL) model was validated in the test set. Based on the AUC and ACC, the best prediction model was identified. To explore the robust of the selected model, ROC analysis was performed the in the external validation set. Moreover, the Log-rank test was applied to evaluate the prognostic value of the model.

Intervention type: DIAGNOSTIC_TEST
Intervention: The Resnet50 deep learning (DL) model
Description: The predictive capability of the above Resnet50 deep learning (DL) model was validated in the test set. Based on the AUC and ACC, the best prediction model was identified. To explore the robust of the selected model, ROC analysis was performed the in the external validation set. Moreover, the Log-rank test was applied to evaluate the prognostic value of the model.
Study: NCT05872217

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: conventional upper extremity therapeutic program
Description: • This group will receive conventional UE therapeutic program for 60 minutes each session including:~* Exercises based on neurodevelopment technique .~* Gentle manual stretching for tight muscles of the affected UE from proximal to distal segments for 5minutes.~* Weight-bearing exercises for 10minutes for UE from prone lying, side sitting and quadriped position.~* Strengthening exercises for 10 minutes for muscles of UE as push-up from prone lying position, quadriped position, 3 point exercise, walk on hand, climbing, hanging on a bar, squeeze stress balls, cutting usescissors to strengthen hand .~* Goal directed training for 10 minutes the child will practice specific tasks that are needed for everyday life and which they find a challenge like (3 daily tasks as cleaning mirror, dressing and undressing, using pen and ruler to draw shapes, brushing teeth .~* Fine motor activities as reach, grasp, carry and release activities.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional upper extremity therapeutic program
Description: • This group will receive conventional UE therapeutic program for 60 minutes each session including:~* Exercises based on neurodevelopment technique .~* Gentle manual stretching for tight muscles of the affected UE from proximal to distal segments for 5minutes.~* Weight-bearing exercises for 10minutes for UE from prone lying, side sitting and quadriped position.~* Strengthening exercises for 10 minutes for muscles of UE as push-up from prone lying position, quadriped position, 3 point exercise, walk on hand, climbing, hanging on a bar, squeeze stress balls, cutting usescissors to strengthen hand .~* Goal directed training for 10 minutes the child will practice specific tasks that are needed for everyday life and which they find a challenge like (3 daily tasks as cleaning mirror, dressing and undressing, using pen and ruler to draw shapes, brushing teeth .~* Fine motor activities as reach, grasp, carry and release activities.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: full immersive VRapeutic software gaming technology
Description: • Children in this group will receive the same conventional UE therapeutic program as control group for 60 minutes in addition to virtual reality session using VRapeutic software gaming technology, Archeeko module (figure 3) for 30 min/3 sessions/week for 8 weeks
Study: NCT05290311

Intervention type: BEHAVIORAL
Intervention: cognitive behavioural therapy
Description: Cognitive behavioural therapy (CBT) was given according to the protocol of Safren (2004, 2005). Each participant followed one session of 60 minutes per week, for 10 to 16 weeks. Psychotherapists giving CBT had at least a master diploma.
Study: NCT05487274

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Total Shoulder Arthroplasty + augmented glenoid component
Description: Replacement of the shoulder joint (ball and socket, or humeral head and glenoid) using prosthetic components. A prosthetic component is also implanted to correct for the amount of bone loss in the shoulder and restore stability.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Reverse Shoulder Arthroplasty
Description: Replacement of the shoulder joint like the TSA, however the orientation of the ball and socket is reversed.
Study: NCT05883956

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Subcutaneous azacitidine
Description: Subcutaneous azacitidine, 75mg/m2, 7 days

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Subcutaneous azacitidine
Description: Subcutaneous azacitidine, 75mg/m2, 7 days

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oral decitabine/cedazuridine
Description: Oral decitabine 35mg/cedazuridine 100mg, once daily, 5 days

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oral decitabine/cedazuridine
Description: Oral decitabine 35mg/cedazuridine 100mg, once daily, 5 days
Study: NCT05752994

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Training in the multisensory room environment
Description: The children will start with the swing follow with the scheduled activities and tabletop activity. The session will end in the relaxation room such as bubble tube, fiberoptic cascade, fiberoptic carpet and aurora projector bundle while the therapist has the interactive communication with children

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Home program
Description: Home program
Study: NCT06031792

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Piezo endodontic surgery
Description: Osteotomy will be done with Piezosurgery touch. After the soft tissue curettage and uncovering the root apex, the last 3 mm of the root apex will be resected perpendicular to the long axis of the tooth using piezotome. apical preparation will be performed and Biodentine®retrograde filling material will be placed. The flap will be re-approximated and interrupted suture using non-absorbable monofilament suture will be applied. Finally, Post-operative parallel Digital view.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Conventional endodontic surgery
Description: After the soft tissue curettage and exposure of the root apex, the osteotomy will be performed using a conventional surgical handpiece. The same steps will be followed to prepare and restore the root, as well as to reposition the flap.
Study: NCT04971668

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Aromatherapy
Description: Three drops of the designated blend aromatherapy (ginger \& lavender) will be placed on a 2-inch by 2-inch impermeable, backed gauze pad and patient will be asked to inhale deeply and simulate like chewing gum for 5 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gum Chewing
Description: Patients will chew gum (sugar free) and inhale deeply with inert gauze for 5 minutes.

Intervention type: OTHER
Group type: OTHER
Intervention: Controlled
Description: Patients will inhale deeply with inert gauze and simulate like chewing gum for 5 minutes.