Study: NCT01970449

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: DNA Nat-B env vaccine
Description: The DNA Nat-B env vaccine will be administered as a 4-mg dose injection intramuscularly (IM) by Biojector 2000 ® in the deltoid muscle of the non-dominant arm (unless medically contraindicated).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NYVAC Nat-B env vaccine
Description: NVYAC Nat-B env vaccine will be administered as a 3 × 10\^7 plaque forming units (pfu) dose IM by needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: DNA CON-S env vaccine
Description: The DNA CON-S env vaccine will be administered as a 4-mg dose injection IM by Biojector 2000 ® in the deltoid muscle of the non-dominant arm (unless medically contraindicated).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NYVAC CON-S env vaccine
Description: NVYAC CON-S env vaccine will be administered as a 3 × 10\^7 pfu dose IM by needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: DNA Mosaic env vaccine
Description: The DNA Mosaic env vaccine will be administered as a 4-mg dose injection IM by Biojector 2000 ® in the deltoid muscle of the non-dominant arm (unless medically contraindicated).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: NYVAC Mosaic env vaccine
Description: NVYAC Mosaic env vaccine will be administered as a 3 × 10\^7 pfu dose IM by needle and syringe in the deltoid muscle of the non-dominant arm (unless medically contraindicated).

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo for both DNA and NYVAC vaccines will be administered in the deltoid muscle of the non-dominant arm (unless medically contraindicated) as sodium chloride for injection, 0.9%.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo for both DNA and NYVAC vaccines will be administered in the deltoid muscle of the non-dominant arm (unless medically contraindicated) as sodium chloride for injection, 0.9%.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo for both DNA and NYVAC vaccines will be administered in the deltoid muscle of the non-dominant arm (unless medically contraindicated) as sodium chloride for injection, 0.9%.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Biojector 2000® Needle-Free Injection Management System™ (Biojector 2000®)
Description: All three DNA env vaccines will be administered IM in the deltoid muscle of the non-dominant arm (unless medically contraindicated) using the Biojector 2000® device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Biojector 2000® Needle-Free Injection Management System™ (Biojector 2000®)
Description: All three DNA env vaccines will be administered IM in the deltoid muscle of the non-dominant arm (unless medically contraindicated) using the Biojector 2000® device.