TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06726889

Intervention type: BEHAVIORAL
Intervention: Decision Support System (DSS)
Description: DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Intervention type: BEHAVIORAL
Intervention: Decision Support System (DSS)
Description: DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Intervention type: BEHAVIORAL
Intervention: Decision Support System (DSS)
Description: DSS will be used to deliver educational material through a web-page (in Italian language) accessible through a link

Intervention type: BEHAVIORAL
Intervention: Reminders
Description: Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)
Study: NCT05077501

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo oral solution
Study: NCT05956756

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Health and resiliency programming
Description: Students will engage in resilience programming as part of their regular coursework including mindfulness training, lifestyle medicine interventions, and creating a coping plan.
Study: NCT05692154

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fexofenadine
Description: Fexofenadine oral tablet

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Fexofenadine matching placebo oral tablet
Study: NCT05894746

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: gluten
Description: see info in arm description
Study: NCT04605146

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Tele-monitoring
Description: The tele-monitoring will consist in filling in a specific questionnaire once a week in the first 6 months, every 2 weeks until 12 months, and on-demand (in case of upcoming toxicity, at any time). These questionnaires will be reviewed by a coordinating nurse. According to the result of the questionnaire, the coordinating nurse will adapt patients' management, either by giving them a phone call, or inviting them to directly contact their medical department, or even plan an emergency hospitalization if necessary. The coordinating nurse will closely work with the investigator to adapt patients' management.~Quality of life questionnaire (FACT-G) will also be filled in at inclusion, M3 and M12.
Study: NCT04570943

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Gabrinox
Description: Regimen: GEMBRAX~Other Names:~Albumin bound paclitaxel 125 mg/m² + Gemcitabine 1000 mg/m²~Regimen: FOLFIRINOX~Other Names:~Oxaliplatin 85 mg/m² + Leucovorin 200 mg/m² + Irinotecan 180 mg/m² + 5FU bolus 400mg/m² + 5FU continuous 2400 mg/m²~Gembrax + Folfirinox = GABRINOX

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: MRI-GUIDED STEREOTACTIC RADIOTHERAPY
Description: Radiotherapy will start between 5 and 6 weeks after the last injection of chemotherapy (FOLFIRINOX regimen) in non-progressive patients after Gabrinox.~Stereotactic adaptive radiotherapy in five fractions: prescription of five fractions of 10 Gy/each on the planning target volume (PTV). At least two sessions/week should be performed. An interval of at least 18 hours between fractions is recommended.
Study: NCT05652218

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LB-CRT
Description: LB-CRT (DDD 60-130, LV lead turned off) (active intervention #1)

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: LB-CRT
Description: LB-CRT (DDD 60-130, LV lead turned off) (active intervention #1)

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: BIV-CRT
Description: BIV-CRT (DDD 60- 130, LV lead turned on) (active intervention #2).

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: BIV-CRT
Description: BIV-CRT (DDD 60- 130, LV lead turned on) (active intervention #2).
Study: NCT06314048

Intervention type: OTHER
Intervention: CGM and RPM
Description: 1. Implement the 4T program as standard of care at Stanford Diabetes clinics, including Continuous Glucose Monitoring (CGM) and Remote Patient Monitoring (RPM) within the first 30 days after T1D diagnosis to reduce the rise in HbA1c trajectory observed 4-12 months post-diagnosis.
Study: NCT05984368

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BG136
Description: Subjects injected with BG136 in Part 1 and Part 2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BG136
Description: Subjects injected with BG136 in Part 1 and Part 2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Subjects injected with Placebo in Part 1 and Part 2
Study: NCT06726889

Intervention type: BEHAVIORAL
Intervention: Reminders
Description: Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)

Intervention type: BEHAVIORAL
Intervention: Reminders
Description: Personalized reminders will be delivered to patients through a common messaging application (WhatsApp)
Study: NCT05984368

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Subjects injected with Placebo in Part 1 and Part 2
Study: NCT05288751

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Contingency Management
Description: Contingency management (CM) is a behavioral intervention that involves incentivizing participants for target behaviors in a clinical setting.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Contingency Management
Description: Contingency management (CM) is a behavioral intervention that involves incentivizing participants for target behaviors in a clinical setting.
Study: NCT04365569

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Nutrition and physical activity counseling program
Description: 6-month interventional, counseling program based on nutrition and physical activity consisting of:~1. Nutritional counseling by a Registered Dietitian (RD) 2) Implementation of an adequate physical activity program
Study: NCT05935722

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Parenting Young Children
Description: PYC is a home-based intervention programme involving weekly, one-hour sessions over a period of at least six months. The programme has two core modules (1) Parent-Child Interaction and (2) Child Care Skills and Safety. The Parent-Child Interaction module focuses on the parent-child relationship and interaction skills such as parents' responsiveness to the child's signals, giving the child attention and encouragement, and supporting prosocial behaviour. The Child Care Skills and Safety module targets safety at home and the parent's caring skills (e.g. food, health, and hygiene). Checklists are adapted to each parent in order to support the PYC practitioner and the parent. The programme is compiled in a manual that includes work tasks, instructions for how to perform the tasks, and teaching materials.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as Usual
Description: TAU consists of a variety of interventions from the social services. The support will be logged and classified in accordance with the Swedish National Board of Health and Welfare's guidelines for classifications of its activities. TAU will be divided into the following five categories: 1) conversation counselling or emotional support, 2) practical support, 3) skills training, 4) compensatory strategies, and 5) other support. Support will also be classified based on whether it is home-based or given outside the home and whether it is individualised or in a group setting.
Study: NCT06309537

Intervention type: DIAGNOSTIC_TEST
Intervention: chemoreflex evaluation
Description: the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants

Intervention type: DIAGNOSTIC_TEST
Intervention: chemoreflex evaluation
Description: the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants

Intervention type: DIAGNOSTIC_TEST
Intervention: chemoreflex evaluation
Description: the ventilatory response to carbon dioxide and hypoxia will be assessed in study participants
Study: NCT05588648

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vactosertib
Description: Vactosertib is given twice a day, five days on and two days off in four-week cycles. Vactosertib is a transforming growth factor-beta (TGF-β) type 1 receptor inhibitor.
Study: NCT06123676

Intervention type: DEVICE
Group type: OTHER
Intervention: Y90-PET-CT scan
Description: 40 min extra PET-CT scan - no extra injection of radiotracer. We image the Y90-microspheres administered to these patients during the therapy
Study: NCT05795881

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cyclic daytime enteral nutrition
Description: The allocated feeding schedule is followed from the start of enteral nutrition after ICU admission until discharge from the ICU.
Study: NCT05125172

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Focus of Attention
Description: Focus of attention instruction and feedback. Focus of attention refers to what people are thinking about during motor tasks. An external focus refers to thinking about an outside outcome or target. An internal focus of attention refers to thinking about how someone is moving their body.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Focus of Attention
Description: Focus of attention instruction and feedback. Focus of attention refers to what people are thinking about during motor tasks. An external focus refers to thinking about an outside outcome or target. An internal focus of attention refers to thinking about how someone is moving their body.
Study: NCT05867888

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: conventional therapy
Description: conventional therapy ( instructions, ice application, deep tissue massage, stretching exercises, joint mobilization and isometric exercises )

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional therapy
Description: conventional therapy ( instructions, ice application, deep tissue massage, stretching exercises, joint mobilization and isometric exercises )

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: conventional therapy
Description: conventional therapy ( instructions, ice application, deep tissue massage, stretching exercises, joint mobilization and isometric exercises )

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: shock wave therapy
Description: Acoustic waves (shock waves) that can carry energy and can propagate through tissues promote healing effects.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: low level laser therapy
Description: The application of light to a biologic system to promote tissue regeneration, reduce inflammation and relieve pain.
Study: NCT04875754

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: ICM-203
Description: Intra-articular injection

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: ICM-203
Description: Intra-articular injection

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: ICM-203
Description: Intra-articular injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Intra-articular injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Intra-articular injection

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Intra-articular injection
Study: NCT06074406

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Hyperfine
Description: Enrolled subjects will undergo a Hyperfine MRI exam, which is a portable, low-field MRI, at various timepoints during their clinical course on ECMO
Study: NCT06457217

Intervention type: DIAGNOSTIC_TEST
Intervention: Magnetic resonance spectroscopic imaging
Description: High-resolution 3D metabolic imaging was performed using the SPICE 1H-MRSI sequence.
Study: NCT05250934

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Robotic rehabilitation
Description: The upper limb rehabilitation will be carried out with the planar rehabilitation robot Icone (a CE Class IIA medical device manufactured by Heaxel). The proposed exercises require the patient to move a cursor on the screen using the end-effector of the robot to reach specific points (planar reaching exercises). When the patient is able to perform these exercises independently, the robot assists the movement by minimizing the interaction force applied to the hand and limiting itself to acquiring the kinematic and dynamic parameters of the exercise, which are useful in determining the state of motor skills. Icone assist the subject by applying a force to his hand that helps him complete the task in the phases where the patient plans the movement correctly but is unable to complete it. As a result, the system will enable you to perform planar elbow and shoulder movements in active, passive, or active-assisted modes, with visual and acoustic feedback.
Study: NCT06397625

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Percutaneous electrical neurostimulation (Placebo)
Description: Group I (Control), will be operated with the same procedure but without electric current, and using placebo needles of the same size (Streitberger Placebo-Needle ® , Asiamed, Pullach, Germany)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Percutaneous electrical neurostimulation
Description: The Group II and III electrostimulation procedure is called peripheral nerve stimulation and is known as an echo-guided peripheral nerve stimulation technique using a blunt, dry needle (active electrode). The intervention will be performed on the pudendal nerve, in an area where there is no risk of perforating any vascular-nerve bundle. The invasive technique will be performed by a physiotherapist expert in musculoskeletal and peripheral nervous system ultrasound and specialized in invasive techniques, with two years of experience in the sector. The needle will be introduced through the anterior (perineum).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Percutaneous electrical neurostimulation
Description: The Group II and III electrostimulation procedure is called peripheral nerve stimulation and is known as an echo-guided peripheral nerve stimulation technique using a blunt, dry needle (active electrode). The intervention will be performed on the pudendal nerve, in an area where there is no risk of perforating any vascular-nerve bundle. The invasive technique will be performed by a physiotherapist expert in musculoskeletal and peripheral nervous system ultrasound and specialized in invasive techniques, with two years of experience in the sector. The needle will be introduced through the anterior (perineum).
Study: NCT06497088

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Nasotrak System
Description: Device: The Nasotrak System~The Nasotrak Medical System is intended to aid, in conjunction with institutional protocols, qualified operators in the placement of the Nasotrak's 12 Fr feeding tube into the stomach of patients requiring enteral feeding after insertion and before every feed. The Nasotrak nasogastric tube(NGT) is designed for use with Nasotrak's handheld device (HHD) which is able to detect the tip of the NGT via piezoelectric sensor, which converts ultrasound waves to electronic signals, thus assisting to track its location as an indicator of placement in the stomach. Nasotrak's NGT is intended only to be used with Nasotrak's HHD.~The Nasotrak NGT is intended for the administration of nutrition, fluids and medications by the nasoenteric route for patients who have an intact gastrointestinal tract but are physically unable to manage nutritional intake through normal mastication and deglutition.
Study: NCT05811013

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Transcranial static magnetic field stimulation (tSMS)
Description: Patients will be randomly assigned to either real or sham tSMS. Real or sham tSMS will be performed daily without any interruption during each session of 60 min. Each patient will be instructed to self-administer tSMS, two sessions per day (AM and PM, 6-10 hours apart), sequentially for 60 minutes each, for 6 +6 months. Patients will choose whether to undergo stimulation at home or in the hospital on an outpatient setting. Real tSMS will be delivered with two cylindrical neodymium magnets (grade N45) of 45 mm diameter and 30 mm of thickness, with a weight of 360 g (MAG45r; Neurek SL, Toledo, Spain), applied with south polarity, each pointing toward the motor cortex. To discharge the weight of the helmet from the head during the sessions, patients will be instructed to rest the back of head and helmet on an inclined surface in a comfortable position. They will be also instructed to rest, minimizing movement, and not to watch audiovisuals during the stimulation sessions.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Transcranial static magnetic field stimulation (tSMS)
Description: Real or sham tSMS will be performed daily without any interruption during each session of 60 min. Each patient will be instructed to self-administer tSMS, two sessions per day (AM and PM, 6-10 hours apart), sequentially for 60 minutes each, for 6 +6 months. Sham tSMS will be delivered with non-magnetic metal cylinders, with the same size, weight and appearance of the magnets (MAG45s; Neurek SL, Toledo, Spain).
Study: NCT06550141

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Emapalumab
Description: An interferon gamma (IFNγ) blocking antibody

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Alkylating agent

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine Phosphate
Description: Purine antagonist antimetabolite

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Axicabtagene Ciloleucel
Description: Autologous treatment
Study: NCT06368674

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intervention group Case Manager (CM)
Description: The CM will be informed about the discharge plan from the nurse at the geriatric ward, as will the municipality for those with need of home help care. An outline of the intervention has been created with managers from primary care and rehabilitation within primary care and municipality care. Core components in the intervention will be active follow-up of the discharge, rehabilitation and care plans. If there are plans that have not been executed or unmet needs, the CM will take adequate contacts to ensure that actions are made to meet the needs. These contacts can be, e.g. the GP for medical needs, the rehabilitation unit in primary or municipality care for unmet rehabilitation needs, and the home help service for unmet care needs. The CM will have a network of contact persons in hospital, primary and community care, as well as in rehabilitation in primary and community care, in order to facilitate for prompt actions to meet the needs.

Intervention type: OTHER
Group type: OTHER
Intervention: Control Group
Description: The participants in the control group with a planned follow-up by a primary health care centre within the catchment area of the Sahlgrenska University Hospital that does not have CMs designated for active follow up of discharged frail older people. Thus, the participants in the control group will not actively be followed-up after discharge.
Study: NCT05855070

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intralesional treatment with Hyaluronic acid
Description: Patients will receive intralesional treatment with Hyaluronic acid (0.8% highly purified sodium salt Hyaluronic acid16 mg/2 mL; Sinovial, IBSA, Lodi, Italy) weekly for 12 weeks.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Intralesional treatment with Verapamil
Description: Patients will receive intralesional treatment with Verapamil (10 mg in 5 mL of normal saline water) weekly for 12 weeks.
Study: NCT05807633

Intervention type: DEVICE
Intervention: Novosyn®
Description: Novosyn® for uterus closure in patients undergoing cesarian section
Study: NCT05523167

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: EFG PH20 SC
Description: Subcutaneous injection of efgartigimod coformulated with rHuPH20, a permeation enhancer

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: PBO
Description: Subcutaneous injection of placebo coformulated with rHuPH20, a permeation enhancer
Study: NCT05796518

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: PREVENT Cardiovascular Health Assessment Tool
Description: Participants will access a heart health information visualization tool online using a personal device or a study tablet computer using their e-mail address to log-in. Investigators will review participant lab results specifically related to their cardiovascular health (e.g. blood pressure, cholesterol) in order to personalize the heart health tool for participants. A brief survey before and after use of the tool will also be completed by participants.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Survey
Description: A brief survey before and after use of the tool will also be completed by participants.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Interview Regarding Heart Health
Description: Participants will be asked questions related to their heart health.
Study: NCT05048862

Intervention type: DIAGNOSTIC_TEST
Intervention: Neuromuscular ultrasound
Description: Ultrasound will be performed with the Affiniti 70 (Philips Medical Instruments, Bothell, WA). all patients following standardized methods of our hospital. All the patient would be checked the skin surface temperature before the ultrasound examination. The image would be exported from the echo machine as DICOM format.

Intervention type: DIAGNOSTIC_TEST
Intervention: Neuromuscular ultrasound
Description: Ultrasound will be performed with the Affiniti 70 (Philips Medical Instruments, Bothell, WA). all patients following standardized methods of our hospital. All the patient would be checked the skin surface temperature before the ultrasound examination. The image would be exported from the echo machine as DICOM format.

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle MRI
Description: Muscle MRI will be performed on a 3-T MR machine (Trio; Siemens, Erlangen, Germany). Each subject will lie in a supine position comfortably, supplied with ear plugs. A high resolution T1 weighted scan and Short-T1 Inversion Recovery series (STIR) of the four limbs muscle were obtained in axial and coronal plane. MR spectroscopy in interested muscle was also sampled to evaluate the composition of fat, water, lactate, and other studied molecules.

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle MRI
Description: Muscle MRI will be performed on a 3-T MR machine (Trio; Siemens, Erlangen, Germany). Each subject will lie in a supine position comfortably, supplied with ear plugs. A high resolution T1 weighted scan and Short-T1 Inversion Recovery series (STIR) of the four limbs muscle were obtained in axial and coronal plane. MR spectroscopy in interested muscle was also sampled to evaluate the composition of fat, water, lactate, and other studied molecules.

Intervention type: DIAGNOSTIC_TEST
Intervention: Nerve conduction studies and autonomic function tests
Description: Nerve conduction study will be performed with a Nicolet Viking IV Electromyographer (Madison, WI) in all patients following standardized methods recommended by the Consensus Development Conference on Standardized Measures in Diabetic Neuropathy. Studied nerves include sural, peroneal, tibial, median and ulnar (motor and sensory) nerves.Autonomic functions will be assessed by the SSR and RRIV with established protocol by using Nicolet Viking IV Electromyographer (Madison, WI).