Study: NCT05994742

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rifampicin
Description: Rifampicin is commonly used in the first-line management of paediatric tuberculosis, and is approved by the FDA (ID: 2862628) and the EMA (EMA/31710/2020).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rifampicin
Description: Rifampicin is commonly used in the first-line management of paediatric tuberculosis, and is approved by the FDA (ID: 2862628) and the EMA (EMA/31710/2020).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin
Description: Azithromycin is a macrolide antibiotic, and is approved for use in children by the FDA (ID: 3263750) and EMA (EMA/2872/2021).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Azithromycin
Description: Azithromycin is a macrolide antibiotic, and is approved for use in children by the FDA (ID: 3263750) and EMA (EMA/2872/2021).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Isoniazid
Description: Isoniazid is an antibiotic commonly used in the firstline treatment of tuberculosis, and as tuberculosis prophylaxis.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Isoniazid
Description: Isoniazid is an antibiotic commonly used in the firstline treatment of tuberculosis, and as tuberculosis prophylaxis.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pyridoxine Hydrochloride
Description: Pyridoxine is a form of vitamin B6 used to prevent peripheral neuropathy among children receiving isoniazid.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pyridoxine Hydrochloride
Description: Pyridoxine is a form of vitamin B6 used to prevent peripheral neuropathy among children receiving isoniazid.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Friendship Bench
Description: The Friendship Bench was developed in Zimbabwe as a low-cost psychological intervention utilising problemsolving therapy (delivered by trained lay workers) and peer-to-peer support to address depression and other common mental disorders. There is a strong evidence base for its use in urban LMIC settings. Peer support groups meet every 1-2 weeks and focus on communal problem solving, and establishing income-generation activities (such as making bags).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Friendship Bench
Description: The Friendship Bench was developed in Zimbabwe as a low-cost psychological intervention utilising problemsolving therapy (delivered by trained lay workers) and peer-to-peer support to address depression and other common mental disorders. There is a strong evidence base for its use in urban LMIC settings. Peer support groups meet every 1-2 weeks and focus on communal problem solving, and establishing income-generation activities (such as making bags).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Care for Child Development
Description: Care for Child Development is a UNICEF package that helps families build stronger relationships and solve problems in caring for the child at home, through play and communication activities to stimulate children, through a series of age-appropriate interactive modules delivered by a lay worker using 'flash' cards. It has been used in other African contexts and has good acceptability.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Care for Child Development
Description: Care for Child Development is a UNICEF package that helps families build stronger relationships and solve problems in caring for the child at home, through play and communication activities to stimulate children, through a series of age-appropriate interactive modules delivered by a lay worker using 'flash' cards. It has been used in other African contexts and has good acceptability.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Educational and behaviour-change modules
Description: Educational and behaviour-change messages around better nutrition; play for children with SAM; stigma,HIV and gender-based violence; financial planning; causes of SAM; and health-seeking behaviours. These have been developed with caregivers affected by SAM in a previous study, through a series of codesign workshops, ensuring these are contextually relevant.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Educational and behaviour-change modules
Description: Educational and behaviour-change messages around better nutrition; play for children with SAM; stigma,HIV and gender-based violence; financial planning; causes of SAM; and health-seeking behaviours. These have been developed with caregivers affected by SAM in a previous study, through a series of codesign workshops, ensuring these are contextually relevant.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Reformulated Ready to Use Therapeutic Food
Description: A reformulated product designed to improve outcomes for children who have severe acute malnutrition.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Reformulated Ready to Use Therapeutic Food
Description: A reformulated product designed to improve outcomes for children who have severe acute malnutrition.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard Care
Description: All children will receive care according to WHO guidelines, which includes standard RUTF and any other medications required.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard Care
Description: All children will receive care according to WHO guidelines, which includes standard RUTF and any other medications required.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard Care
Description: All children will receive care according to WHO guidelines, which includes standard RUTF and any other medications required.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard Care
Description: All children will receive care according to WHO guidelines, which includes standard RUTF and any other medications required.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Standard Care
Description: All children will receive care according to WHO guidelines, which includes standard RUTF and any other medications required.