TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04650919

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Total laryngectomy and reconstruction by stented aortic allograft (using human tissue and device).
Description: The procedure consists of 2 operating times:~* Surgery S1 (1st surgical procedure): total laryngectomy and placement of the stented aortic graft (human tissue + device: NOVATECH GSS TM (trademark) TD), under tracheotomy cover.~* Surgery S2 (2nd surgical procedure) (between S1 +24 weeks and S1 +36 weeks) : opening of the proximal part of the graft by endoscopic way with maintenance of the tracheotomy orifice to ensure patient safety.
Study: NCT04933474

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: painTRAINER®
Description: PainTRAINER is among the most widely-validated mHealth interventions for pain management.18-25 Originally developed by members of our team at Duke and Northwestern University under NIH funding, the app teaches evidence-based pain coping skills using a self-administered, home-based software program. The system delivers eight sessions via any web-connected platform, including Android or iOS smartphones, tablets, or personal computers. The digital curriculum covers progressive muscle relaxation, activity/rest cycling, pleasant activity scheduling, recognizing negative automatic thoughts, pleasant imagery/distraction, problem solving, and monitoring for maintenance. Patients complete one session per week in a pre-determined order. The program can be completed in a flexible manner to accommodate life and medical events.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: PICO G2 4k
Description: Patients allocated this arm will use a multi-modal, skills-based, selfmanagement VR program, called EaseVRx. Developed by AppliedVR (Los Angeles, CA) in partnership with Stanford pain psychologist Dr. Beth Darnall, the program teaches and trains users based on evidenced-based strategies and biofeedback exercises. EaseVRx combines psychoeducation, pain education, breathing training, relaxation exercises, and executive functioning games to provide a mind-body approach toward living better with pain. The standardized, reproducible, 56-day program delivers a combination of skills training and CBT-related treatments through scheduled daily virtual experiences. Each VR experience lasts between 2-16 minutes.
Study: NCT06088511

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: The Exercise Training
Description: For the 8-week self-management phase, the participants will be recommended to follow the lifestyle interventions to relieve their problems related to sarcopenia. The participants in the experimental group will also be suggested to continually practise exercise training at home for 30 minutes at least 5 times per week. Participants can review the self-learning exercise videos embedded in the System. The exercise trainings include: a) progressive resistance training to improve muscle strength; and b) brisk walking exercise to maintain walkability.
Study: NCT05670457

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Diosmin
Description: diosmin 500 mg twice daily
Study: NCT06361212

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Ethoximod
Description: Ethoximod is a S1P1 modulator.
Study: NCT06578871

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Intensity Modulated Radiotherapy (IMRT) to Mucosa at Risk
Description: Patients in Arm 1, after the surgical procedure, will receive radiotherapy to the at-risk mucosa.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgical Intervention
Description: These patients will undergo Neck dissection, TORS tonsillectomy (unilateral vs bilateral tonsillectomy at the discretion of the treating physician) + ipsilateral tongue base mucosectomy.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Surgical Intervention
Description: These patients will undergo Neck dissection, TORS tonsillectomy (unilateral vs bilateral tonsillectomy at the discretion of the treating physician) + ipsilateral tongue base mucosectomy.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Intensity Modulated Radiotherapy (IMRT) to Ipsilateral Neck
Description: For Arm1, after the surgical procedure, the patients will receive radiotherapy to the ipsilateral neck. For Arm2, the patients will only receive IMRT to neck, if multiple ipsilateral nodes or single ipsilateral node \>3 cm is observed

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Intensity Modulated Radiotherapy (IMRT) to Ipsilateral Neck
Description: For Arm1, after the surgical procedure, the patients will receive radiotherapy to the ipsilateral neck. For Arm2, the patients will only receive IMRT to neck, if multiple ipsilateral nodes or single ipsilateral node \>3 cm is observed
Study: NCT06361212

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ethoximod
Description: Ethoximod is a S1P1 modulator.
Study: NCT05344209

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: UV1
Description: UV1 vaccine

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Sagramostim
Description: for stimulation of local dendritic cell population to take up the vaccine and to mature into professional APCs

Intervention type: DRUG
Group type: OTHER
Intervention: Anti-PD-1/PD-L1 treatment
Description: either pembrolizumab, atezolizumab or cemiplimab

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anti-PD-1/PD-L1 treatment
Description: either pembrolizumab, atezolizumab or cemiplimab
Study: NCT05437328

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: bi-4SCAR GD2/CD56 T cells
Description: Infusion of bi-4SCAR GD2/CD56 T cells at 10\^6 cells/kg body weight via IV
Study: NCT05527418

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dasatinib
Description: Dasatinib monotherapy 70 mg/day, during 16 weeks.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo during 16 weeks.
Study: NCT05585801

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Dexcom G6 continuous glucose monitor
Description: Continuous glucose monitor will be used to measure interstitial glucose and aid in guiding the insulin therapy to achieve target blood glucose range of 6-10 mmol/l.~In the control group, blood glucose will be measured according to standards of care and a blinded continuous monitor will be used to compare the time i range between the arms.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Blood glucose measurements according to standards of care
Description: Blood glucose will be measured using point of care glucose meter and standard biochemistry methods. Blinded CGM will be applied to obtain continuous glucose values for post-hoc comparison.
Study: NCT06143033

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: DIME Beauty Luminosity Eye Serum
Description: Test product contains: Water/Aqua, Organic Aloe Vera Juice, Lycium Barbarum (Goji Berry) Fruit Extract, Vitis Vinifera (Grape Seed) Extract, Cucumis Sativus (Cucumber) Extract, Glycerin, Niacinamide, Squalane, Camellia Seed Oil, DL-Panthenol (Vitamin B5), Carbomer, Sodium Hyaluronate, Ammonium Acryloyldimethyltaurate/VP Copolymer, Phenoxyethenol, Caprylyl Glycol, Acacia Senegal Gum, Caffeine, Helianthus Annuus (Sunflower) Seed Oil, Malus Domestica (Apple) Fruit Stem Cell Extract, Argania Spinosa (Argan) Sprout Stem Cell Extract, Tetrahexyldecyl Ascorbate (Vitamin C), Acetyl Tetrapeptide, Acetyl Hexapeptide-8, Vitamin E Mixed Tocopherols, Sodium Hydroxide.
Study: NCT06228690

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gold Fish exercises
Description: Specific exercise for the flexibility of TMJ that will target the Jaw muscles. Frequency: 3 times/week for 4 weeks Intensity: moderate intensity (pain free) Time: 30-45 minutes Type: Gold Fish exercises for jaw flexibility, pain and maximum mouth opening.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cervico-thoracic postural correction training
Description: Cervico-thoracic postural correction training for upper thoracic and neck muscles.~Frequency: 3 times/week for 4 weeks Intensity: moderate intensity (pain free) Time: 30-45 minutes Type: Muscle energy technique to improve range of motion, pain and maximum mouth opening.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional PT treatment
Description: Conventional PT including Hot Pack for 10mins, Active-Passive neck Stretching Exercise + jaw Isometric Exercises.~* Frequency: hold followed by 5secs rest. 2-3times for 3 times/week for 4 weeks, Intensity: moderate-high intensity (depending on pain tolerance) Time: 30-45 mins for Active-Passive neck Stretching.~* Frequency: 3secs hold, 6 times repetitions for Isometric Exercises. Type: conventional treatment for pain, ROM, MMO.
Study: NCT04752332

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Abemaciclib
Description: Administered orally.
Study: NCT06404983

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Opioid Free Anaesthesia (OFA)
Description: Patients are allocated to receive non-opioid anaesthesia intraoperatively. Patients will receive a mixture of dexmedetomidine, ketamine and lidocaine for intraoperative analgesia.
Study: NCT04752332

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard Adjuvant ET
Description: Administered according to label instructions.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Standard Adjuvant ET
Description: Administered according to label instructions.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo
Description: Administered orally.
Study: NCT06425432

Intervention type: DEVICE
Intervention: OVITZ xwave aberrometer
Description: wavefront aberrometer

Intervention type: DEVICE
Intervention: OVITZ xwave aberrometer
Description: wavefront aberrometer
Study: NCT06404983

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Conventional General Anaesthesia (CGA)
Description: Patients are allocated to receive conventional general anaesthesia intraoperatively with the use of fentanyl and morphine for intraoperative analgesia.
Study: NCT05152888

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Evolocumab
Description: Evolocumab is a human monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9). Evolocumab was FDA approved in 2015 for the treatment of hyperlipidemia and subsequently approved in 2017 for the prevention of stroke and heart attack. 140mg single use SureClick autoinjector that is administered subcutaneously once every 2 weeks.
Study: NCT06007599

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Skin closure using skin adhesive
Description: Wound closure using subcuticular running 3-0 monocryl sutures with skin adhesive

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Skin closure without skin adhesive
Description: Wound closure using subcuticular running 3-0 monocryl sutures without skin adhesive
Study: NCT03961412

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: family-based intervention
Description: The participants will identify their accompanying influential person(s) (e.g., spouse, partners, parents, children, friends) with whom they will be attending the 1.5-2 hour face-to-face education session on cervical cancer and screening. At the end of the intervention, time will be allowed for questions, as well as distributing fridge magnets and a pamphlet. Fridge magnets contain Pap test guidelines and availability of local clinics. The pamphlet covers the following topics: (a) information about female anatomy and cervical cancer, (b) risk factors for cervical cancer, (c) facts of cervical cancer incidence and mortality, and screening rates among American women, (d) methods to reduce cervical cancer (e.g., HPV vaccination), (e) Pap test procedure, (f) Pap test guidelines, and (g) availability of clinics and cost of Pap test. The participants will be encouraged to spread the message to family members and friends.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Participant only intervention
Description: Only participant will attend the 1.5-2 hour face-to-face education session on cervical cancer and screening. At the end of the intervention, time will be allowed for questions, as well as distributing fridge magnets and a pamphlet. Fridge magnets contain Pap test guidelines and availability of local clinics. The pamphlet covers the following topics: (a) information about female anatomy and cervical cancer, (b) risk factors for cervical cancer, (c) facts of cervical cancer incidence and mortality, and screening rates among American women, (d) methods to reduce cervical cancer (e.g., HPV vaccination), (e) Pap test procedure, (f) Pap test guidelines, and (g) availability of clinics and cost of Pap test. The participants will be encouraged to spread the message to family members and friends.
Study: NCT06475040

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: transcranial magnetic stimulation
Description: non-invasive form of brain stimulation accelerated intermittent theta burst stimulation (aiTBS)
Study: NCT06379282

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: HIT
Description: Exercise training only

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: EXE+ Nutritional Guidance
Description: Exercise Training + Nutritional Guidance
Study: NCT05521321

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Stanford Cannabis Awareness and Prevention curriculum
Description: Stanford Cannabis Awareness and Prevention curriculum delivered as a 5-session course administered in a school classroom setting.
Study: NCT05574465

Intervention type: DEVICE
Group type: OTHER
Intervention: High resolution solid state manometry
Description: The use of esophageal manometry device during removal of endotracheal tube by anesthesia
Study: NCT04893759

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pelcitoclax
Description: Multiple dose cohorts, 30 minute IV infusion, once a week, 28 days as a cycle
Study: NCT05939505

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Su Jok therapy
Description: Sujok therapy will be applied with Mexican bean seeds 14 times with an interval of one day.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo
Description: Instead of the Mexican bean seed applied in sujok therapy, plastic beans will be applied 14 times with an interval of one day.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: routine interventions
Description: routine applications in the hemodialysis unit

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: routine interventions
Description: routine applications in the hemodialysis unit

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: routine interventions
Description: routine applications in the hemodialysis unit
Study: NCT06462378

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Proton therapy
Description: External beam proton therapy combined with standard cisplatin and brachytherapy
Study: NCT05574361

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Hypothermic Machine Perfusion
Description: Organ Recovery Systems LifePort® Liver Transporter (LLT) System and Vasosol® Machine Perfusion Solution
Study: NCT04931966

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: block
Description: Adductor canal block

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: block
Description: Adductor canal block

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: block
Description: Adductor canal block

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: adductor canal block
Description: adductor canal block bupivacain

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: adductor canal block
Description: adductor canal block bupivacain

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: adductor canal block
Description: adductor canal block bupivacain

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Adductor Canal Block plus IPACK Block
Description: Adductor Canal Block plus IPACK Block using bupivacaine

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: adductor Canal Block plus PAI Block
Description: Adductor Canal Block plus PAI Block using bupivacaine
Study: NCT06330610

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Intermittent enteral nutrition
Description: Patients will receive intermittent enteral nutrition, defined as 3 60-minute administrations every 8 hours.
Study: NCT05178862

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SCY-078
Description: Oral ibrexafungerp (SCY-078) as step-down therapy.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fluconazole
Description: Oral fluconazole (SCY-078) as step-down therapy.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Echinocandin
Description: Intravenous echinocandin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Echinocandin
Description: Intravenous echinocandin
Study: NCT05849519

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Coenzyme I for Injection + conventional treatment
Description: The intervention group used Coenzyme I for injection and conventional treatment for 7 consecutive days

Intervention type: DRUG
Group type: OTHER
Intervention: Conventional treatment
Description: The control group was treated with conventional treatment
Study: NCT05325385

Intervention type: OTHER
Intervention: There are no interventions - this is a database study only
Description: There are no interventions - this is a database study only
Study: NCT05201950

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual simulation
Description: Virtual simulation using Full-Code, a virtual simulation software with a bank of emergency medicine cases

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Team based in situ simulation
Description: In situ simulation, using a high fidelity manikin in the critical care area of the emergency department, with team members consisting of multiple junior doctors and nurses, facilitated by senior emergency medicine doctors and nurses.
Study: NCT06007053

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: ReACT
Description: ReACT is a novel cognitive behavioral treatment and is a PNES intervention that targets sense of control and catastrophic symptom expectations. ReACT consists of 12 sessions of therapy focused on teaching adolescents to regain control of their body through managing thoughts and behaviors that reinforce the PNES and return to previous activities. It teaches parents how to respond to PNES in a manner that encourages the adolescents to regain control of their body. The PNES is explained as behaviors learned through classical and operant conditioning.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Supportive Therapy
Description: The supportive therapy treatment consists of 12 sessions of therapy focused on discussing daily difficulties and/or stressors they experience and identifying stress triggers for PNES. The PNES is explained as physical manifestations of psychological stress.
Study: NCT05870891

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Food
Description: Food

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Food
Description: Food
Study: NCT03890029

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Intervention Training
Description: After pre-testing and randomization, intervention participants will meet in small groups for 60 minutes/week over eight weeks for resilience training. Participants needing extra help will receive it at the end of each session. Controls will be on a minimal attention list, not being trained. After eight weeks, all participants will be post-tested.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Control Condition
Description: While intervention participants receive resilience training, the control group will not receive training but will receive minimal attention of a bi-monthly telephone call to indicate to participants that they are still enrolled in the study. A monthly flyer will be mailed to them about wellness and PTSD in recent news coverage. Following completion of an intervention group, participants and controls will be scheduled for post-testing that will be identical to the pre-testing and will occur within two weeks after the final treatment session. After the post-testing and 3-month follow up testing, the controls will be offered the resilience training.
Study: NCT05778734

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: CM-PST
Description: CM-PST is a tailored behavioral intervention that enables young adults with AUD to successfully manage and overcome everyday life challenges influencing their alcohol intake.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: CM only
Description: CM is a behavior therapy that rewards individuals for evidence of positive change (alcohol abstinence).
Study: NCT06649110

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LTP
Description: LTP001

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LTP
Description: LTP001

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: LTP
Description: LTP001

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo
Study: NCT06722651

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Netrod™ six-electrode radiofrequency renal denervation system
Description: Netrod™ renal denervation (RDN) system, which is indicated for the treatment of uncontrolled hypertension. It consists of the following two components:~* Netrod™ Six-Electrode Basket Radiofrequency Renal Denervation Catheter and~* Netrod™ Renal Denervation Radiofrequency Generator The catheter's electrodes deploy into a self-adaptive basket structure, optimizing contact with the vessel wall for effective ablation.

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: Sham Procedure
Description: Patients will be remained on the catheterization table for at least 20 min prior to sheath removal.
Study: NCT06757530

Intervention type: DIAGNOSTIC_TEST
Intervention: AI
Description: Using artificial intelligence models to distinguish between patients with lymph node metastasis and those without lymph node metastasis.
Study: NCT05713136

Intervention type: DEVICE
Intervention: Diagnostic Test: Point-of-Care Testing
Description: Participants will be offered finger-stick point-of-care testing for HCV