TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT04722523

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Cisplatin 75mg/m2 AUC 5 on weeks 2, 5, and 8

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Carboplatin AUC 5 on weeks 2, 5, and 8

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Docetaxel
Description: Docetaxel 75mg/m2 on weeks 2, 5, and 8

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cetuximab
Description: Cetuximab 400mg/m2 on week 1, 250mg/m2 on weeks 2, 3, 4, 5, 6, 7, 8, 9, 10

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cetuximab
Description: Cetuximab 400mg/m2 on week 1, 250mg/m2 on weeks 2, 3, 4, 5, 6, 7, 8, 9, 10

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cemiplimab
Description: Cemiplimab 350mg on weeks 2, 5, 8, 11; if adjuvant radiation +/- chemotherapy is omitted, Cemiplimab will be administered on weeks 16, 19, 22, 25, 28, 31, 34, 37

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cemiplimab
Description: Cemiplimab 350mg on weeks 2, 5, 8, 11; if adjuvant radiation +/- chemotherapy is omitted, Cemiplimab will be administered on weeks 16, 19, 22, 25, 28, 31, 34, 37

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgical Resection of Primary +/- Neck Dissection
Description: Twenty-eight days (+ 7 days) following the 3rd cycle of neoadjuvant therapy, patients will then undergo definitive surgical resection of the primary site +/- neck dissection(s).

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Post-operative radiation therapy
Description: Post-operative radiation therapy +/- radiosensitizing agent(s) will be administered per standard-of-care based on pathologic staging of the surgical specimen. If there is an excellent response to treatment with a high degree of downstaging the addition of adjuvant radiation may be omitted if NCCN guidelines are met. If the pathologic stage following induction systemic therapy and surgery is ypT1-2N0 without the presence of adverse features that include positive margins or a combination of perineural invasion, vascular invasion, and a depth of invasion of \>0.5mm, adjuvant radiation will not be administered, consistent with the NCCN guidelines \[2\]. Otherwise, patients will receive adjuvant RT-based treatment with standard radiation techniques.
Study: NCT04829500

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Montessori Approaches to Person-Centered Care (MAP-VA)
Description: Montessori approaches to person-centered care (MAP-VA) introduces practical strategies that frontline staff can use for successful engagement of residents through retained abilities. Staff are also introduced to concrete strategies that improve dignity, control, and independence. MAP-VA is based on the work of Maria Montessori who demonstrated that a structured, supportive environment and meaningful, active roles in the classroom enabled children to fulfill their greatest potential physically, mentally, and emotionally. Montessori principles have been applied to dementia care for more than 20 years to promote functional independence, meaningful engagement, and dignity.
Study: NCT04722523

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: If participants are unable to receive Docetaxel due to lack of insurance approval or due to an allergic reaction, Docetaxel can be substituted with Paclitaxel. Paclitaxel would be dosed at 90 mg/m2 on weeks 2, 3, 5, 6, 8 and 9.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: If participants are unable to receive Docetaxel due to lack of insurance approval or due to an allergic reaction, Docetaxel can be substituted with Paclitaxel. Paclitaxel would be dosed at 90 mg/m2 on weeks 2, 3, 5, 6, 8 and 9.
Study: NCT05191394

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Evolution of antibodies titre
Description: For each patient included in this study, 3 blood samples of 5 ml(serum) will be collected at well-defined time points: at the beginning of an TPE session, at the end of the same session, and at the beginning of the consecutive TPE session.
Study: NCT06268054

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: DEH113
Description: Tablets
Study: NCT06245993

Intervention type: OTHER
Intervention: EOS imaging
Description: EOS imaging 3 years after skin traction treatment for femoral shaft fracture.
Study: NCT06268054

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo Comparator
Description: Tablets
Study: NCT05977400

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ampicillin
Description: Intravenous Ampicillin

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Gentamicin
Description: Intravenous Gentamicin

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Intravenous Normal Saline
Study: NCT06198387

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: hormone and RT
Description: The patients will receive a two-year course of androgen deprivation therapy (ADT) in combination with abiraterone, along with synchronous metastasis-directed radiation and prostate radiotherapy(RT).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ADT combined with abiraterone
Description: The patients will receive a two-year course of ADT combined with abiraterone.
Study: NCT05939934

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Mandibular advancement device treatment
Description: a titratable thermoplastic mandibular advancement device will be proposed to patient in the experimental group during the 2 weeks of CPAP withdrawal.
Study: NCT04796909

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Occupational Performance coaching
Description: The OPC intervention comprises three components: (1) connect - building parents' trust in the coach by using verbal and nonverbal strategies; (2) structure - building parents' competence by adopting a problem-solving framework of setting goals, exploring options, planning action, carrying out plans, checking performance, and generalizing; and (3) share - building parents' autonomy by reciprocally exchanging information between the coach and parents with an emphasis on eliciting parents existing knowledge. During the exploration of the options for a particular goal, collaborative performance analysis is used. The coach follows the four steps to (a) identify parents' perception of what currently happens, (b) identify what they would like to happen, (c) explore barriers and bridges to the desired performance, and (d) identify their needs for taking actions to achieve goals. Parents are guided to find strategies to facilitate their child's performance to support goal achievement.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Parent consultation
Description: The parent consultation consists of the use of the toolbox to provide parents with available environmental resources and strategies to enhance community participation of their child with developmental disability, followed by the understanding of current situation and the identification of problems encountered by parents. Direct informing approach will be used to instruct parents about the availability of environmental resources close to their living areas and what they can plan to do by using possible supportive strategies. In addition, information about child disability and/or developmental milestone may be provided if needed.
Study: NCT04930081

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Positive Parenting Program, Mindful Parenting
Description: The Positive Parenting Program (Triple P) consists of 5 weekly group sessions (each lasting for 2 hours) plus three weekly individual telephone interview sessions (each lasting for around 20 minutes). Program materials is available in Chinese.~The Mindful Parenting program consists of 8 weekly group sessions, each lasting for 2 hours. Programme materials have already been translated into Chinese by local partners of the programme developer.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Positive Parenting Program, Mindful Parenting
Description: The Positive Parenting Program (Triple P) consists of 5 weekly group sessions (each lasting for 2 hours) plus three weekly individual telephone interview sessions (each lasting for around 20 minutes). Program materials is available in Chinese.~The Mindful Parenting program consists of 8 weekly group sessions, each lasting for 2 hours. Programme materials have already been translated into Chinese by local partners of the programme developer.
Study: NCT04782609

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Icapamespib
Description: to test the safety, tolerability and pharmacokinetics of single agent oral icapamespib in patients with recurrent brain lesions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Icapamespib
Description: to test the safety, tolerability and pharmacokinetics of single agent oral icapamespib in patients with recurrent brain lesions.
Study: NCT05135442

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bortezomib Injection
Description: Bortezomib should be administered immediately after each plasma exchange, and the interval between the next plasma exchange is\> 24h. Plasma exchange continued until the patient's platelet count was \>100×109/L for 2 consecutive days, and then changed to once every other day for a total of two times and then stopped.
Study: NCT05793736

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Biofeedback training
Description: The intervention lasts 5 weeks, twice a week, each session lasts 45 minutes in which HRV (Heart Rate Variability) is detected, through plethysmographic sensors placed on the finger or earlobe during assigned tasks. During tasks that involve progressively more complex phases, they allow the person to receive immediate feedback on the video screen.
Study: NCT05072392

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Foley catheter
Description: Using a 16G Foley catheter to cover the tip of the endotracheal tube as it passes through the nose. This is done in comparison to the standard practice of directly passing an endotracheal tube through the nose without a cover.~Both groups use warmed endotracheal tubes and the use of topical vasoconstrictor (4 sprays of 0.1% xylometazoline to each nare).
Study: NCT05734599

Intervention type: DEVICE
Intervention: NMR-based metabolic profiling
Description: Clinical parameters and VCTE results of each patient will be collected. Patients will be grouped into two groups according to VCTE, FIB-4 and NFS, and undergo NMR-based metabolic profiling

Intervention type: DEVICE
Intervention: NMR-based metabolic profiling
Description: Clinical parameters and VCTE results of each patient will be collected. Patients will be grouped into two groups according to VCTE, FIB-4 and NFS, and undergo NMR-based metabolic profiling

Intervention type: DEVICE
Intervention: NMR-based metabolic profiling
Description: Clinical parameters and VCTE results of each patient will be collected. Patients will be grouped into two groups according to VCTE, FIB-4 and NFS, and undergo NMR-based metabolic profiling
Study: NCT05268640

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Double-level cervical cerclage
Description: two cervical sutures + regimen of antibiotics + indomethacin + progesterone

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Single-level cervical cerclage
Description: single cervical suture + regimen of antibiotics + indomethacin + progesterone
Study: NCT04879693

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Continuous Glucose Monitoring System
Description: Continuous Glucose Monitoring System
Study: NCT05438719

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MOTUS Total Joint Replacement
Description: The MOTUS Total Joint Replacement is indicated for the biomechanical reconstruction and stabilization of a spinal motion segment following decompression at one lumbar level from L1/L2 to L5/S1 for skeletally mature patients due to symptomatic lumbar degeneration with or without foraminal or recess spinal stenosis confirmed by radiographic imaging (CT, MRI, X-rays), with no more than a Grade 1 spondylolisthesis at the involved level.
Study: NCT05697198

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors

Intervention type: DIAGNOSTIC_TEST
Intervention: OmniSeq Test
Description: Genomic and immune profiling assay for all solid tumors
Study: NCT06403462

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: transversalis fascial plane block
Description: ultrasound guidance transversalis fascial plane block after iliac bone graft

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: transversus abdominis plane block
Description: ultrasound guidance lateral transversus abdominis plane block after iliac bone graft
Study: NCT05892601

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Maternal kisses
Description: The parents of the children in the experimental group were informed about the process before the application. The parents were asked to approach their child immediately after the invasive procedure was over, call out Let me kiss it better and kiss the child from a point not close to the place where the invasive procedure was applied. Kisses were delivered by the mother, free of oral ulcers, with a standard 5-second pressing of both lips on the affected body part followed by an exaggerated puckering sound. Pain, fear, and anxiety scales were administered to the intervention group at the 1st and 5th minutes after the application. Invasive interventions have been applied by researchers who have been working as nurses in the emergency room for 4 years.
Study: NCT05566067

Intervention type: OTHER
Intervention: Survey
Description: There will be no interventions for study participants. Participants will be asked to complete a survey.
Study: NCT03966768

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Duramesh suturable mesh for laparotomy closure
Description: Patients undergoing laparotomy will be closed with Duramesh suturable mesh

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Duramesh suturable mesh for laparotomy closure
Description: Patients undergoing laparotomy will be closed with Duramesh suturable mesh
Study: NCT05045261

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: administration of SLGN in arm C
Description: administration of 3mg SLGN weekly for 24 weeks in arm C

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Discontinuation of NUC treatment in arms B and C
Description: NUC treatment will be stopped after 28 weeks in arms B and C
Study: NCT03966768

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Conventional suture for laparotomy closure
Description: Patients undergoing laparotomy will be closed with conventional polydiaxonone suture
Study: NCT04096833

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Virtual Reality Group
Description: Participants are from 3 to 14 years old who attend a pediatric primarey health care of the Fuensanta Health Center (Valencia) for immunization by vaccine.
Study: NCT05045261

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Discontinuation of NUC treatment in arms B and C
Description: NUC treatment will be stopped after 28 weeks in arms B and C
Study: NCT05289843

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Rosmarinus Officinallis
Description: Root canal Irrigants
Study: NCT05335551

Intervention type: DIAGNOSTIC_TEST
Intervention: Patients monitored with TruGraf and TRAC Liver testing
Description: This is an observational study there are no protocol mandated interventions. TruGraf and TRAC Liver results will be utilized in conjunction with standard of care assessments to determine patient management in the study arm.
Study: NCT04873401

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Chain-referral
Description: In the chain-referral intervention, a discrete number of seeds will be recruited from the community partners, trained and incentivized to recruit and refer members of their social networks to receive COVID-19 testing. The peer recruiters are paid for each suvcessful and eligible recruit who enrolls to be tested. Those individuals are then themselves trained to recruit peers from their social networks to receive COVID-19 testing. This is repeated over a period of 4-6 months.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Credible Messenger
Description: In the credible messenger intervention, peers noted to be popular and socially influential individuals with lived experience will be trained to engage within community settings and areas to encourage community members to receive COVID-19 testing at the community partnering agencies. Peers will recruit community members over a period of 4-6 months.
Study: NCT05467189

Intervention type: DRUG
Intervention: Busulfan, Paclitaxel, Afatinib, Ceritinib, Crizotinib (Antineoplastic drugs)
Description: As part of routine treatment.
Study: NCT04645667

Intervention type: DRUG
Intervention: Tacrolimus
Description: Patients will be enrolled into this group if they receive tacrolimus per standard of care. This is an observational study and no interventions will be made.
Study: NCT04926649

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Differential ventilation to the non-dependent lung
Description: When the hypoxemia occurs during sing lung ventilation in robot-assisted cardiac surgery, the non-dependent lung will be ventilated with normal tidal volume in conventional ways and the surgery procedure have to be ceased. In this trial, the non-dependent lung will be ventilated with the continuous positive airway pressure (CPAP) or the high-frequency low-volume ventilation (HFLVV) to prevent the hypoxemia.

Intervention type: PROCEDURE
Group type: SHAM_COMPARATOR
Intervention: Differential ventilation to the non-dependent lung
Description: When the hypoxemia occurs during sing lung ventilation in robot-assisted cardiac surgery, the non-dependent lung will be ventilated with normal tidal volume in conventional ways and the surgery procedure have to be ceased. In this trial, the non-dependent lung will be ventilated with the continuous positive airway pressure (CPAP) or the high-frequency low-volume ventilation (HFLVV) to prevent the hypoxemia.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Differential ventilation to the non-dependent lung
Description: When the hypoxemia occurs during sing lung ventilation in robot-assisted cardiac surgery, the non-dependent lung will be ventilated with normal tidal volume in conventional ways and the surgery procedure have to be ceased. In this trial, the non-dependent lung will be ventilated with the continuous positive airway pressure (CPAP) or the high-frequency low-volume ventilation (HFLVV) to prevent the hypoxemia.
Study: NCT05161728

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: PSMA-PET/CT
Description: PSMA-PET/CT
Study: NCT04617977

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: I-BMS for families with children suffering from eczema
Description: It is a strength-based, family system approach to aid empowerment of individuals. It focuses on the interplay between physical and emotional well-being, the spiritual transformation of adverse life experiences, and the acceptance of adversity through reflection on the philosophical concepts of forgiveness and letting go. It integrates Western therapeutic techniques and Eastern philosophies to develop spiritual transformation through suffering and pain under a meaning-oriented framework. It consists of six three-hour consecutive weekly sessions: (1) awareness of body-mind connection; (2) regulation of emotion; (3) acknowledgement of the gains and losses in the caregiving or illness experience; (4) appreciation of self and others; (5) cultivation of acceptance; and (6) meaning reconstruction of caregiving or illness experience.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: I-BMS for families with children suffering from eczema
Description: It is a strength-based, family system approach to aid empowerment of individuals. It focuses on the interplay between physical and emotional well-being, the spiritual transformation of adverse life experiences, and the acceptance of adversity through reflection on the philosophical concepts of forgiveness and letting go. It integrates Western therapeutic techniques and Eastern philosophies to develop spiritual transformation through suffering and pain under a meaning-oriented framework. It consists of six three-hour consecutive weekly sessions: (1) awareness of body-mind connection; (2) regulation of emotion; (3) acknowledgement of the gains and losses in the caregiving or illness experience; (4) appreciation of self and others; (5) cultivation of acceptance; and (6) meaning reconstruction of caregiving or illness experience.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Health education for parents whose children have eczema
Description: It focuses on practical eczema management. It serves as a control for group effect between conditions. It consists of six three-hour sessions: (1) information about the physiology of eczema and its health impact; (2) recognition and avoidance of trigger factors and daily skin care; (3) dealing with itching and scratching; (4) stage-related treatment of symptoms and unconventional therapies; (5) general child nutrition, food allergies in eczema, and different forms of diets; and (6) self-management plan and problems in integrating into daily routine.
Study: NCT05890768

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lumateperone
Description: FDA approved antipsychotic drug

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Risperidone
Description: FDA approved antipsychotic drug
Study: NCT06312527

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Silicone dressing
Description: Participant will apply silicone dressing at 2 weeks after TKA on one side of knee.~Silicone dressing will change every week until 12 week postoperative.
Study: NCT05793736

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Treatment as usual
Description: The sample will be treated only with standard therapies (treatment as usual) without the use of biofeedback training
Study: NCT02703610

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Oxycodone/acetaminophen
Description: Patients will be discharged home with a 3 day supply of oxycodone/acetaminophen

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ibuprofen/acetaminophen
Description: Patients will be discharged home with a 3 day supply of ibuprofen/acetaminophen