TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT06751940

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Conventional second-line therapy
Description: Conventional second-line therapy includes chemotherapy, targeted cancer drugs, and/or PD-1 inhibitors.The chemotherapy drugs, dosage and treatment cycle are determined by the subject's attending physician based on the subject's specific conditions. The medication, dosage and treatment cycle of targeted cancer drugs will be determined by the subject's attending physician based on the subject's specific circumstances. The PD-1 inhibitor treatment cycle is 3 weeks, and the drug is administered by intravenous infusion on the first day (D1) of each treatment cycle. The dosage is based on the instructions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Neoantigen-loaded DC vaccine
Description: The treatment with personalized tumor neoantigen-loaded DC vaccine is divided into two periods: the primary phase and the boost phase. The primary phase consists of 6 treatments, with the first 3 treatments spaced one week apart and the subsequent 3 treatments spaced two weeks apart. Vaccine will be administrated on the fourth day (D4) of that week. The boost phase consists of 4 treatments, each spaced three weeks apart. Vaccine will be administrated on the fourth day (D4) of that week.
Study: NCT06752655

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Curcumin with photodynamic thearpy
Description: root canals will irrigated with final irrigation procedure: curcumin+photodynamic therapy. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control group
Description: root canals will irrigated with routine root canal final irrigation with NaOCl and EDTA. The teeth will be isolated with a rubber dam, and an access cavity will be created. After root canal preparation, the final irrigation procedure will be performed. Root canal treatments will be completed, and the patients' postoperative pain levels will be recorded using follow-up forms.
Study: NCT06753006

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Neurorehabilitation simulator
Description: The participant must complete a mental task - imagine the movement of his arm. If successful, the robotic simulator moves the paralyzed limb.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Neurorehabilitation simulator
Description: The participant must complete a mental task - imagine the movement of his arm. If successful, the robotic simulator moves the paralyzed limb.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Neurorehabilitation simulator
Description: The participant must complete a mental task - imagine the movement of his arm. If successful, the robotic simulator moves the paralyzed limb.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Standard course
Description: The participant receives a standard course of intervention as prescribed by the attending physician in accordance

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard course
Description: The participant receives a standard course of intervention as prescribed by the attending physician in accordance

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard course
Description: The participant receives a standard course of intervention as prescribed by the attending physician in accordance

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Standard course
Description: The participant receives a standard course of intervention as prescribed by the attending physician in accordance
Study: NCT06754280

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: RESET-CKD
Description: RESET-CKD is a 12-week intervention that consists of four major components to support decreasing sedentary behavior: (1) health coaching, (2) feedback charts on sedentary behavior, (3) a workbook, and (4) reminders and cues.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Attention Control
Description: CKD-related education
Study: NCT06754020

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Heart Rate Variability,HRV - ANSWatch
Description: Please have the participant lie down and rest for 10 minutes, and remove any metallic items from their body. Next, put on the wrist-worn monitor, and avoid moving during the monitoring process. The device will emit a sound when the monitoring session is complete.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Heart Rate Variability,HRV - ANSWatch
Description: Please have the participant lie down and rest for 10 minutes, and remove any metallic items from their body. Next, put on the wrist-worn monitor, and avoid moving during the monitoring process. The device will emit a sound when the monitoring session is complete.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Traditional Chinese Medicine Tongue Imaging
Description: Use a camera to capture images of the tongue, and then have a Traditional Chinese Medicine (TCM) practitioner perform the diagnosis based on these images.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Traditional Chinese Medicine Tongue Imaging
Description: Use a camera to capture images of the tongue, and then have a Traditional Chinese Medicine (TCM) practitioner perform the diagnosis based on these images.
Study: NCT06751472

Intervention type: DIAGNOSTIC_TEST
Intervention: VPS (Verbal Pain Score)
Description: İt is a pain intensity determination system based on the system where there person tells a point between 0=(no pain) 10=( unbearable pain) and to describe their pain

Intervention type: DIAGNOSTIC_TEST
Intervention: WOMAC (Western Ontario and McMaster Universities Arthritis Index) scale
Description: It includes 24 questions under three sub-headings as pain, stiffness and physical function
Study: NCT06755112

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo cream
Description: Placebo cream application
Study: NCT05024071

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wushu athletes in the experimental group used a Swiss ball for 12 weeks of core strength training
Description: The experimental group was given 12 weeks of core strength training, divided into 6 types~1. Static action under steady state.~2. No load movement in steady state.~3. Static action under unstable state.~4. Movement to overcome its own resistance in an unstable state.~5. Free strength exercise in unstable state.~6. Core explosive power exercise under unstable conditions.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wushu athletes in the experimental group used a Swiss ball for 12 weeks of core strength training
Description: The experimental group was given 12 weeks of core strength training, divided into 6 types~1. Static action under steady state.~2. No load movement in steady state.~3. Static action under unstable state.~4. Movement to overcome its own resistance in an unstable state.~5. Free strength exercise in unstable state.~6. Core explosive power exercise under unstable conditions.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wushu athletes in the experimental group used a balance board for 12 weeks of core strength training
Description: The experimental group was given 12 weeks of core strength training, divided into 6 types~1. Static action under steady state.~2. No load movement in steady state.~3. Static action under unstable state.~4. Movement to overcome its own resistance in an unstable state.~5. Free strength exercise in unstable state.~6. Core explosive power exercise under unstable conditions.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Wushu athletes in the experimental group used a balance board for 12 weeks of core strength training
Description: The experimental group was given 12 weeks of core strength training, divided into 6 types~1. Static action under steady state.~2. No load movement in steady state.~3. Static action under unstable state.~4. Movement to overcome its own resistance in an unstable state.~5. Free strength exercise in unstable state.~6. Core explosive power exercise under unstable conditions.
Study: NCT04912466

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Biological: IBI322
Description: Recombinant anti-human CD47/PD-L1 bispecific antibody injection
Study: NCT05482984

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: video-recorded role-play and guided reflection
Description: The experimental group was divided into 6 teams. Before the course, the teacher in charge and each group developed six scenarios: restraint, suicidal intent, respiratory distress, chronic heart failure, medication refusal, and accidental amputation. The researcher guided each group to write scripts about the clinical situations (30 minutes), create role-play videos (50 minutes), and share literature that was helpful in understanding this context (30 minutes). Each student played a role in the filming process. The final film was viewed by all the students during class. Each live class session was 50 minutes in length, with one session per week for 6 weeks. All students were asked to attend six video-viewing sessions and participate in a reflective discussion.
Study: NCT06755112

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: active cream
Description: Active cream application
Study: NCT06753916

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Corneal Donor Tissue with Cross Linking
Description: Participants are transplanted with corneal donor tissue that has been treated with 0.1% riboflavin (Vitamin B2) and 20% dextran (Photrexa® Viscous \& Photrexa®) with UV light treatment.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Corneal Donor Tissue without Cross Linking
Description: Participants are transplanted with corneal donor tissue that has not been treated with the UV light and the 0.1% riboflavin (Vitamin B2) and 20% dextran (Photrexa® Viscous \& Photrexa®) without UV light treatment, this is the control group.
Study: NCT06755398

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Exercise
Description: During the exercises based on the protocol developed by the Royal Dutch Society for Physical Therapy (KNGF) following anterior cruciate ligament (ACL) surgery, additional cognitive tasks will be assigned to the patients.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercise
Description: The protocol developed by the Royal Dutch Society for Physical Therapy (KNGF) will be applied following anterior cruciate ligament (ACL) surgery.
Study: NCT06754228

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic Agent
Description: Bacillus coagulans JBI-YZ6.3 (BC4U)

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Probiotic Agent
Description: An escalating dose cross-over design: Participants are fed 0 mg, 100 mg, 200 mg, and 400 mg on different clinic visits.
Study: NCT06752291

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: water flosser
Description: A water flosser will be provided for use throughout the study, with participants instructed to use it once daily, specifically at the end of the day before bedtime.
Study: NCT06754774

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Shoulder Endurance Test
Description: Each patient receive the same intervention, the Shoulder Endurance Test (SET). The Shoulder Endurance Test assesses the endurance of the shoulder muscles in an open kinetic chain.
Study: NCT06755086

Intervention type: DRUG
Intervention: 18-FDG
Description: All study participants will undergo one 18F-FDG PET/ CT scan.
Study: NCT06754579

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: High-Volume Upper Extremity Exercises Training
Description: The group will be trained 3 days a week for a total of 8 weeks.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Low Volume Upper Extremity Exercises Training
Description: The group will be trained 3 days a week for a total of 8 weeks.
Study: NCT06751602

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Belumosudil 200 mg QD
Description: Belumosudil 200 mcg oral daily

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo (once daily)
Study: NCT06754176

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Randomized instructions
Description: Alcohol Non-Avoidance: In this intervention assignment, participants will be allowed to drink alcohol for this day.~Alcohol Avoidance: In this intervention assignment, participants will be instructed to avoid drinking alcohol for this day.
Study: NCT06752434

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Deep brain stimulation
Description: active DBS with optimal stimulating parameters

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Deep brain stimulation
Description: active DBS with optimal stimulating parameters
Study: NCT05416489

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: C-MAC videolayngoscopy technique
Description: Endotracheal tube will be removed before percutaneous tracheostomy using a C-MAC videolaryngoscopy.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Laryngoscopy technique
Description: Endotracheal tube will be removed before percutaneous tracheostomy using a laryngoscopy
Study: NCT06180486

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Mindfulness Meditation Intervention
Description: The mindfulness intervention is a scripted, \~12min audio recording based on core tenets of mindfulness meditation and contextualized for patients undergoing total knee arthroplasty. It teaches sustained attention on the present, body awareness, acceptance of the body's current state, and transformational strategies to cope with emotional or physical stimuli as they arise. It has been created by the study team based on the teachings of Jon Kabat Zinn (founder of mindfulness meditation) and the PI's history teaching yoga and meditation. Patients will be encouraged to review the audio recording once a week.

Intervention type: OTHER
Group type: OTHER
Intervention: Mindfulness Meditation Intervention
Description: The mindfulness intervention is a scripted, \~12min audio recording based on core tenets of mindfulness meditation and contextualized for patients undergoing total knee arthroplasty. It teaches sustained attention on the present, body awareness, acceptance of the body's current state, and transformational strategies to cope with emotional or physical stimuli as they arise. It has been created by the study team based on the teachings of Jon Kabat Zinn (founder of mindfulness meditation) and the PI's history teaching yoga and meditation. Patients will be encouraged to review the audio recording once a week.
Study: NCT06459102

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Motor Learning
Description: In addition to the conventional physiotherapy program .... per week for 4 weeks Sessions of motor learning exercise will be performed. For the exercise, the participant will sit in a chair with back support, in front of a table, with arms on the table. The participant will wear a glove with an IMU sensor on the upper surface and a pressure sensor on the palm, and a cylinder will be placed in the palm. The participant will be asked to bring the wrist into extension and then back into flexion while grasping the cylinder with maximum force. The participant will be asked to maintain maximum strength during the entire movement. The participant will be given visual feedback on muscle strength and range of motion of the wrist on the monitor in front of them throughout the movement. The same protocol will be applied by keeping the size of the cylinder in the participant's palm the same and changing the weight.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Control
Description: The control group will receive a conventional physiotherapy program for 4 weeks, 5 days a week. Eccentric training for the extensor carpi radialis brevis (ECRB) muscle, the most affected wrist extensor tendon, and static stretching exercises for the ECRB muscle will be given. For eccentric training, the weight that the patients can lift in 10 maximal repetitions will be calculated and they will be asked to work with this weight. The best stretching position for the ECRB tendon is extension of the elbow joint, pronation of the forearm and flexion of the wrist with ulnar deviation. Each participant will be taught to perform each exercise for 10 repetitions and 10 seconds. Patients will perform these exercises in a sitting position. In the control group, daily exercises will be performed under the supervision of a physiotherapist
Study: NCT04900792

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ferumoxytol injection
Description: Ferumoxytol is an iron replacement product FDA approved for treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD). This trial uses the FDA approved dosage (512 mg iron) for iron-deficiency anemia in CKD.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ferumoxytol injection
Description: Ferumoxytol is an iron replacement product FDA approved for treatment of iron deficiency anemia in adult patients with chronic kidney disease (CKD). This trial uses the FDA approved dosage (512 mg iron) for iron-deficiency anemia in CKD.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pharmacological ascorbate
Description: Intravenous ascorbate

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pharmacological ascorbate
Description: Intravenous ascorbate

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: External beam radiation therapy
Description: Photon based, focal radiation therapy delivered consistent with national guidelines, standard for treatment of GBM.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: External beam radiation therapy
Description: Photon based, focal radiation therapy delivered consistent with national guidelines, standard for treatment of GBM.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Temozolomide
Description: Temozolomide is a cytotoxic alkylating agent administered orally that penetrates well into the central nervous system. It is a standard-of-care treatment for GBM.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Temozolomide
Description: Temozolomide is a cytotoxic alkylating agent administered orally that penetrates well into the central nervous system. It is a standard-of-care treatment for GBM.
Study: NCT06280196

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: BAT3306
Description: One vial of 4 mL of concentrate contains 100 mg of BAT3306

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: EU-Keytruda®
Description: One vial of 4 mL of concentrate contains 100 mg of pembrolizumab

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: US-Keytruda®
Description: One vial of 4 mL of concentrate contains 100 mg of pembrolizumab

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pemetrexed
Description: 500 mg/m2 on Day 1 of each 21-day cycle of the study
Study: NCT05840016

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: AK112, Carboplatin, Paxlitaxel
Description: IV infusion,Specified dose on specified days

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Tislelizumab, Carboplatin, Paxlitaxel
Description: IV infusion,Specified dose on specified days
Study: NCT06280196

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pemetrexed
Description: 500 mg/m2 on Day 1 of each 21-day cycle of the study

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pemetrexed
Description: 500 mg/m2 on Day 1 of each 21-day cycle of the study

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Target AUC of 5 mg/mL/min on Day 1 of each 21-day cycle up to 4 cycles

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carboplatin
Description: Target AUC of 5 mg/mL/min on Day 1 of each 21-day cycle up to 4 cycles

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carboplatin
Description: Target AUC of 5 mg/mL/min on Day 1 of each 21-day cycle up to 4 cycles
Study: NCT04806880

Intervention type: DEVICE
Intervention: Web-application
Description: support for olfactory coaching consisting of the inhalation of fragrant essential oils.
Study: NCT05934084

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Lifestyles Implemented-Survivorship Care Plan (LS-SCP)
Description: Patients in the experimental arm will follow the planned intervention (Survivorship Care Plan (SCP), nutritional plan, physical activity) for 6 months. A bi-monthly automatic call to assess the compliance at the experimental arm (LS-SCP, Lifestyles implemented-Survivorship Care Plan) will be performed.
Study: NCT06450132

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atropine Ophthalmic
Description: 0.05% atropine ophthalmic solution

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: MiSight 1-day disposable contact lenses
Description: soft multifocal contact lenses
Study: NCT05338970

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Patritumab Deruxtecan
Description: Intravenous administration, 5.6 mg/kg every 3 weeks (q3W)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Platinum-based chemotherapy
Description: Intravenous, pemetrexed 500 mg/m\^2 plus either cisplatin (75 mg/m\^2) or carboplatin (target area under the plasma concentration time curve of 5 \[AUC5\] by using the Calvert formula) q3W
Study: NCT05386888

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GFH018
Description: Administered as oral

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Toripalimab
Description: Administered as an IV infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: Administered as an IV infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Administered as an IV infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Administered as an IV infusion

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pemetrexed
Description: Administered as an IV infusion

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Thoracic Radiation Therapy (TRT)
Description: Thoracic Radiation Therapy (TRT)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GFH018
Description: Administered as an IV infusion
Study: NCT05942001

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HRS-5041
Description: HRS-5041 was given oral administration, qd, at a 28-day cycle. Patients may continue to use HRS-5041 until disease progression or unacceptable toxicity occurs.