Study: NCT03917680

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Factor XII dosage
Description: Factor XII (FXII, Hageman factor) will be measured in plasma. It is converted to FXIIa by an activator. The FXIIa protease cleaves a chromogenic substrate and releases p-nitroaniline (pNA), which can be measured photometrically.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Factor XII dosage
Description: Factor XII (FXII, Hageman factor) will be measured in plasma. It is converted to FXIIa by an activator. The FXIIa protease cleaves a chromogenic substrate and releases p-nitroaniline (pNA), which can be measured photometrically.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Factor XII dosage
Description: Factor XII (FXII, Hageman factor) will be measured in plasma. It is converted to FXIIa by an activator. The FXIIa protease cleaves a chromogenic substrate and releases p-nitroaniline (pNA), which can be measured photometrically.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Factor XII dosage
Description: Factor XII (FXII, Hageman factor) will be measured in plasma. It is converted to FXIIa by an activator. The FXIIa protease cleaves a chromogenic substrate and releases p-nitroaniline (pNA), which can be measured photometrically.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Factor XII dosage
Description: Factor XII (FXII, Hageman factor) will be measured in plasma. It is converted to FXIIa by an activator. The FXIIa protease cleaves a chromogenic substrate and releases p-nitroaniline (pNA), which can be measured photometrically.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: p.Thr328Lys mutation detection
Description: Sequencing of exon 9 of franking introns of FXII, for identification of the p.Thr328Lys mutation.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: p.Thr328Lys mutation detection
Description: Sequencing of exon 9 of franking introns of FXII, for identification of the p.Thr328Lys mutation.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: p.Thr328Lys mutation detection
Description: Sequencing of exon 9 of franking introns of FXII, for identification of the p.Thr328Lys mutation.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: p.Thr328Lys mutation detection
Description: Sequencing of exon 9 of franking introns of FXII, for identification of the p.Thr328Lys mutation.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: p.Thr328Lys mutation detection
Description: Sequencing of exon 9 of franking introns of FXII, for identification of the p.Thr328Lys mutation.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Videocapillaroscopy
Description: It is an optical method to visualize the most superficial part of the cutaneous microcirculatory network. It provides morphological information.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Videocapillaroscopy
Description: It is an optical method to visualize the most superficial part of the cutaneous microcirculatory network. It provides morphological information.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Videocapillaroscopy
Description: It is an optical method to visualize the most superficial part of the cutaneous microcirculatory network. It provides morphological information.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Videocapillaroscopy
Description: It is an optical method to visualize the most superficial part of the cutaneous microcirculatory network. It provides morphological information.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Videocapillaroscopy
Description: It is an optical method to visualize the most superficial part of the cutaneous microcirculatory network. It provides morphological information.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Videocapillaroscopy
Description: It is an optical method to visualize the most superficial part of the cutaneous microcirculatory network. It provides morphological information.