Study: NCT02808676

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Vitamin D3
Description: Dose: 10000 IU, three times per week, orally.

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Vitamin D3
Description: Dose: 10000 IU, three times per week, orally.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercises (E)
Description: All participants will complete three (3) group training sessions per week (total 20 weeks), under the supervision of trainers. Each exercise session will last approximately 60 minutes and will happen after the cognitive training/control (CT cCT) session. The exercise session will be a combined aerobic and progressive strengthening exercise. Within each small group of four to eight individuals, participants follow the program tailored to their individual functioning level, with constant monitoring by the trainers. Participants are expected to attend all training sessions and research staff will strongly encourage them to do so.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercises (E)
Description: All participants will complete three (3) group training sessions per week (total 20 weeks), under the supervision of trainers. Each exercise session will last approximately 60 minutes and will happen after the cognitive training/control (CT cCT) session. The exercise session will be a combined aerobic and progressive strengthening exercise. Within each small group of four to eight individuals, participants follow the program tailored to their individual functioning level, with constant monitoring by the trainers. Participants are expected to attend all training sessions and research staff will strongly encourage them to do so.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercises (E)
Description: All participants will complete three (3) group training sessions per week (total 20 weeks), under the supervision of trainers. Each exercise session will last approximately 60 minutes and will happen after the cognitive training/control (CT cCT) session. The exercise session will be a combined aerobic and progressive strengthening exercise. Within each small group of four to eight individuals, participants follow the program tailored to their individual functioning level, with constant monitoring by the trainers. Participants are expected to attend all training sessions and research staff will strongly encourage them to do so.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Exercises (E)
Description: All participants will complete three (3) group training sessions per week (total 20 weeks), under the supervision of trainers. Each exercise session will last approximately 60 minutes and will happen after the cognitive training/control (CT cCT) session. The exercise session will be a combined aerobic and progressive strengthening exercise. Within each small group of four to eight individuals, participants follow the program tailored to their individual functioning level, with constant monitoring by the trainers. Participants are expected to attend all training sessions and research staff will strongly encourage them to do so.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cognitive Training (CT)
Description: CT intervention will involve computer-based multimodal and multi-domain dual-task training with memory load. A custom-written program, developed for neuro-rehabilitation and used in previous research trials for cognitive and mobility outcomes will be used. Training sessions will take place in groups of four to eight participants before each of the fitness-training session for duration of 30 min max. Participants will perform a concurrent visuo-motor task (dual-task combination) composed of different sets of visual stimuli that have to be identified by tapping designated figures on an digital tablet (IOS or Android system). Participants will perform discrimination tasks involving sets of items (e.g. letters, numbers, animals, vehicles, fruits, celestial bodies).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Cognitive Training (CT)
Description: CT intervention will involve computer-based multimodal and multi-domain dual-task training with memory load. A custom-written program, developed for neuro-rehabilitation and used in previous research trials for cognitive and mobility outcomes will be used. Training sessions will take place in groups of four to eight participants before each of the fitness-training session for duration of 30 min max. Participants will perform a concurrent visuo-motor task (dual-task combination) composed of different sets of visual stimuli that have to be identified by tapping designated figures on an digital tablet (IOS or Android system). Participants will perform discrimination tasks involving sets of items (e.g. letters, numbers, animals, vehicles, fruits, celestial bodies).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: placebo D3
Description: matching placebo for Vitamin D3

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: placebo D3
Description: matching placebo for Vitamin D3

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: placebo D3
Description: matching placebo for Vitamin D3

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: control cognitive training
Description: As a control activity to ensure the same time exposure as in the interventions arms, participant in the control arm will receive a 30 min computer skills training.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: control cognitive training
Description: As a control activity to ensure the same time exposure as in the interventions arms, participant in the control arm will receive a 30 min computer skills training.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: control cognitive training
Description: As a control activity to ensure the same time exposure as in the interventions arms, participant in the control arm will receive a 30 min computer skills training.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo exercise
Description: As a control activity to ensure the same time exposure as in the interventions arms, participant in the control arm will receive a 60 min of a tone exercise regimen