Study: NCT02780128

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Biopsy
Description: Needle or incisional tumor biopsy

Intervention type: GENETIC
Group type: OTHER
Intervention: Next Generation Sequencing
Description: Tumor tissue will be sent to Foundation Medicine laboratory for molecular profiling.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Tumor Scans
Description: Participants will undergo different types of scans to look at your tumor. These scans include CT (computerized tomography), MIBG (meta-iodobenzylguanidine) PET (positron emission tomography), and MRI (magnetic resonance imaging). Participants may have more than one type of scan.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Tumor Scans
Description: Participants will undergo different types of scans to look at your tumor. These scans include CT (computerized tomography), MIBG (meta-iodobenzylguanidine) PET (positron emission tomography), and MRI (magnetic resonance imaging). Participants may have more than one type of scan.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone marrow Tests
Description: Participants will have needles inserted through their hip bone to remove fluid from inside the bone marrow. This test determines if participants have tumor in the bone marrow.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Physical Exam
Description: The exam includes taking participant weight, height, blood pressure, heart rate and respiratory rate and performing a examination of the participants body. The investigators may also check the participants vision with an eye chart.

Intervention type: OTHER
Group type: OTHER
Intervention: Physical Exam
Description: The exam includes taking participant weight, height, blood pressure, heart rate and respiratory rate and performing a examination of the participants body. The investigators may also check the participants vision with an eye chart.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Eye Exam
Description: Participants will have their eyes will be evaluated using different instruments. Participants will also be asked to read an eye chart. The exams will take about 15 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Labs
Description: Standard blood tests will be done to measure different types of blood cells, to measure the amount of certain substances, and tests to check how well liver and kidneys are working. When possible, the investigators will take blood from the participants central line. If this is not possible, the investigators will take blood from a vein in the participants arm. First, the investigators will put some cream on the skin so that drawing blood will not be painful. Then the investigators will put a thin needle into the vein to draw the blood.

Intervention type: OTHER
Group type: OTHER
Intervention: Labs
Description: Standard blood tests will be done to measure different types of blood cells, to measure the amount of certain substances, and tests to check how well liver and kidneys are working. When possible, the investigators will take blood from the participants central line. If this is not possible, the investigators will take blood from a vein in the participants arm. First, the investigators will put some cream on the skin so that drawing blood will not be painful. Then the investigators will put a thin needle into the vein to draw the blood.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Pregnancy Test
Description: If the participant is 11 years old or older or has already started having periods, the participant will be asked to take a pregnancy test before starting this study. The results will be shared with the participant but not with the participants' parent(s). We strongly encourage the participant to share the results with the parents. If the participant is found to be pregnant, the participant will not be able to continue participation in the study. About 1 teaspoon of blood (or urine if a urine test) will be needed.

Intervention type: OTHER
Group type: OTHER
Intervention: Pregnancy Test
Description: If the participant is 11 years old or older or has already started having periods, the participant will be asked to take a pregnancy test before starting this study. The results will be shared with the participant but not with the participants' parent(s). We strongly encourage the participant to share the results with the parents. If the participant is found to be pregnant, the participant will not be able to continue participation in the study. About 1 teaspoon of blood (or urine if a urine test) will be needed.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Interviews
Description: A team member will take the participant's medical history, along with a listing of any medications that are being taken. Throughout the study, participants will be asked to report if they think that anything bad has happened as a result of the study.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Interviews
Description: A team member will take the participant's medical history, along with a listing of any medications that are being taken. Throughout the study, participants will be asked to report if they think that anything bad has happened as a result of the study.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: ECG
Description: This is a test of electrical activity of the heart. The investigators will put electrodes (sticky pads attached to wires) on the participant's chest, arms and legs. The electrocardiogram (ECG) will not be uncomfortable, but the participant will have to lie still. It does not hurt and takes about 15 minutes.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Echocardiogram
Description: The participant will have an ultrasound of the heart taken to assess heart function. The investigators will put some gel on the skin and use a machine to take pictures of the heart.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ribociclib
Description: Participants will take ribociclib once per day orally for Days 1-21 of a 28-day cycle.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ceritinib
Description: Participants will take ceritinib once per day orally for 28 days of a 28-day cycle.