Study: NCT04031599

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Single-hormone closed-loop system
Description: Every 10 minutes, the glucose levels as measured by the sensor will be transferred automatically to a LG Google Nexus Smartphone that the algorithm is running on, which will calculate the recommended doses and will send them wirelessly to the infusion pump.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Single-hormone closed-loop system
Description: Every 10 minutes, the glucose levels as measured by the sensor will be transferred automatically to a LG Google Nexus Smartphone that the algorithm is running on, which will calculate the recommended doses and will send them wirelessly to the infusion pump.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Insulin pump
Description: Tandem Diabetes Care

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Insulin pump
Description: Tandem Diabetes Care

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Continuous glucose monitoring system
Description: Dexcom G6

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Continuous glucose monitoring system
Description: Dexcom G6

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aspart or Lispro
Description: Aspart or lispro will be infused with the infusion pump

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Aspart or Lispro
Description: Aspart or lispro will be infused with the infusion pump

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Carbohydrate counting
Description: Participants will be required to enter an estimate of the carbohydrate content of their meal into the phone. Insulin boluses will be calculated based on grams of carbohydrates and participant's insulin-to-carbohydrate ratio. Carbohydrate-matching full prandial bolus will be given 5 to 10 minutes before the meal.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Simplified qualitative meal-size estimation strategy
Description: A pre-meal partial prandial bolus will be given 5-10 minutes before the meal. The partial bolus will be based on the estimated meal size (small, regular, large and extra-large). The closed-loop system will give the remaining insulin needed based on the sensor readings. For this strategy, meal size will be defined as: small as any meal less than 30g, regular meal as any meal between 30g and 60g CHO, large meal as any meal between 60g and 90g CHO, extra-large meal for anything above 90g CHO.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 3-week intervention
Description: Glucose levels will be regulated by the single-hormone closed-loop system for 3 consecutive weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 3-week intervention
Description: Glucose levels will be regulated by the single-hormone closed-loop system for 3 consecutive weeks.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 1-hour postprandial exercise (sub-study)
Description: 60 minute exercise will be started one hour after the meal time.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 2-hour postprandial exercise (sub-study)
Description: 60 minute exercise will be started two hours after meal time

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Exercise announcement and meal bolus reduction (sub-study)
Description: Meal bolus reduction of 33% at meal time and exercise announcement (increased target glucose from 6 to 9mmolL) to the CLS algorithm