Study: NCT03291821

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: human menopausal gonadotropin
Description: human menopausal gonadotropin subcutaneously

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: human menopausal gonadotropin
Description: human menopausal gonadotropin subcutaneously

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: GnRH antagonist
Description: GnRH antagonist subcutaneously

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GnRH antagonist
Description: GnRH antagonist subcutaneously

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: GnRH analog
Description: GnRH analog subcutaneously

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GnRH analog
Description: GnRH analog subcutaneously

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Trophectoderm biopsy
Description: Trophectoderm biopsy is the process of removing few cells from an in vitro fertilization embryo.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Trophectoderm biopsy
Description: Trophectoderm biopsy is the process of removing few cells from an in vitro fertilization embryo.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: MitoScore
Description: The cells removed from an in vitro fertilization embryo during the trophectoderm biopsy will be used to assess the mitochondrial DNA content as a viability indicator in the euploid embryos.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: MitoScore
Description: The cells removed from an in vitro fertilization embryo during the trophectoderm biopsy will be used to assess the mitochondrial DNA content as a viability indicator in the euploid embryos.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Intracytoplasmic sperm injection
Description: ICSI is an in vitro fertilization procedure in which a single sperm is injected directly into an oocyte.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intracytoplasmic sperm injection
Description: ICSI is an in vitro fertilization procedure in which a single sperm is injected directly into an oocyte.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Ovarian puncture
Description: Egg retrieval is a simple procedure. It is performed in an operating room for safety reasons. It is performed vaginally and involves aspirating the follicular fluid through a thin needle. Embryologists then retrieve from this fluid the eggs that have matured during stimulation. It lasts for 5 to 15 minutes, and a mild sedative is administered to prevent any kind of pain during the procedure.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Ovarian puncture
Description: Egg retrieval is a simple procedure. It is performed in an operating room for safety reasons. It is performed vaginally and involves aspirating the follicular fluid through a thin needle. Embryologists then retrieve from this fluid the eggs that have matured during stimulation. It lasts for 5 to 15 minutes, and a mild sedative is administered to prevent any kind of pain during the procedure.

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Preimplantation genetic test
Description: The cells removed from an in vitro fertilization embryo during the trophectoderm biopsy will be tested for chromosomal normalcy before transferring the embryo to the uterus.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Preimplantation genetic test
Description: The cells removed from an in vitro fertilization embryo during the trophectoderm biopsy will be tested for chromosomal normalcy before transferring the embryo to the uterus.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Embryo transfer
Description: Embryo transfer refers to a step in the process of assisted reproduction in which embryos are placed into the uterus

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Embryo transfer
Description: Embryo transfer refers to a step in the process of assisted reproduction in which embryos are placed into the uterus

Intervention type: DIAGNOSTIC_TEST
Group type: ACTIVE_COMPARATOR
Intervention: Pregnancy test
Description: A pregnancy test is used to determine whether a woman is pregnant.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Pregnancy test
Description: A pregnancy test is used to determine whether a woman is pregnant.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Embryo freezing
Description: Embryo freezing is a method for cryopreserving embryos.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Embryo freezing
Description: Embryo freezing is a method for cryopreserving embryos.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Embryo thawing
Description: Embryo thawing is the procedure to recover previously frozen embryos prior to an embryo transfer.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Embryo thawing
Description: Embryo thawing is the procedure to recover previously frozen embryos prior to an embryo transfer.