Study: NCT03572114

Intervention type: DIAGNOSTIC_TEST
Intervention: 3Tesla MRI
Description: 1. A previously validated multi-parameter mapping protocol sensitive to neuromelanin and iron content~2. Iron mapping and micro-bleed detection: QSM (quantitative susceptibility mapping), a fully flow-compensated, susceptibility-weighted gradient-echo sequence (5 minutes).~3. 1-mm isotropic anatomical MPRAGE (magnetization-prepared rapid gradient-echo)~4. conventional FLAIR sequence

Intervention type: DIAGNOSTIC_TEST
Intervention: 3Tesla MRI
Description: 1. A previously validated multi-parameter mapping protocol sensitive to neuromelanin and iron content~2. Iron mapping and micro-bleed detection: QSM (quantitative susceptibility mapping), a fully flow-compensated, susceptibility-weighted gradient-echo sequence (5 minutes).~3. 1-mm isotropic anatomical MPRAGE (magnetization-prepared rapid gradient-echo)~4. conventional FLAIR sequence

Intervention type: DIAGNOSTIC_TEST
Intervention: 3Tesla MRI
Description: 1. A previously validated multi-parameter mapping protocol sensitive to neuromelanin and iron content~2. Iron mapping and micro-bleed detection: QSM (quantitative susceptibility mapping), a fully flow-compensated, susceptibility-weighted gradient-echo sequence (5 minutes).~3. 1-mm isotropic anatomical MPRAGE (magnetization-prepared rapid gradient-echo)~4. conventional FLAIR sequence

Intervention type: DIAGNOSTIC_TEST
Intervention: 3Tesla MRI
Description: 1. A previously validated multi-parameter mapping protocol sensitive to neuromelanin and iron content~2. Iron mapping and micro-bleed detection: QSM (quantitative susceptibility mapping), a fully flow-compensated, susceptibility-weighted gradient-echo sequence (5 minutes).~3. 1-mm isotropic anatomical MPRAGE (magnetization-prepared rapid gradient-echo)~4. conventional FLAIR sequence

Intervention type: DIAGNOSTIC_TEST
Intervention: 3Tesla MRI
Description: 1. A previously validated multi-parameter mapping protocol sensitive to neuromelanin and iron content~2. Iron mapping and micro-bleed detection: QSM (quantitative susceptibility mapping), a fully flow-compensated, susceptibility-weighted gradient-echo sequence (5 minutes).~3. 1-mm isotropic anatomical MPRAGE (magnetization-prepared rapid gradient-echo)~4. conventional FLAIR sequence

Intervention type: DIAGNOSTIC_TEST
Intervention: 3Tesla MRI
Description: 1. A previously validated multi-parameter mapping protocol sensitive to neuromelanin and iron content~2. Iron mapping and micro-bleed detection: QSM (quantitative susceptibility mapping), a fully flow-compensated, susceptibility-weighted gradient-echo sequence (5 minutes).~3. 1-mm isotropic anatomical MPRAGE (magnetization-prepared rapid gradient-echo)~4. conventional FLAIR sequence

Intervention type: BEHAVIORAL
Intervention: Burke-Fahn-Marsden Dystonia Rating scale
Description: internationally standardized examination/quantification of dystonia

Intervention type: BEHAVIORAL
Intervention: Burke-Fahn-Marsden Dystonia Rating scale
Description: internationally standardized examination/quantification of dystonia

Intervention type: BEHAVIORAL
Intervention: Burke-Fahn-Marsden Dystonia Rating scale
Description: internationally standardized examination/quantification of dystonia

Intervention type: BEHAVIORAL
Intervention: Burke-Fahn-Marsden Dystonia Rating scale
Description: internationally standardized examination/quantification of dystonia

Intervention type: BEHAVIORAL
Intervention: Burke-Fahn-Marsden Dystonia Rating scale
Description: internationally standardized examination/quantification of dystonia

Intervention type: BEHAVIORAL
Intervention: Burke-Fahn-Marsden Dystonia Rating scale
Description: internationally standardized examination/quantification of dystonia

Intervention type: BEHAVIORAL
Intervention: MDS-United Parkinsons Disease Rating Scale, Part III
Description: most recent, internationally standardized examination/quantification of bradykinesia / rigidity according to the Movement Disorder Society

Intervention type: BEHAVIORAL
Intervention: MDS-United Parkinsons Disease Rating Scale, Part III
Description: most recent, internationally standardized examination/quantification of bradykinesia / rigidity according to the Movement Disorder Society

Intervention type: BEHAVIORAL
Intervention: MDS-United Parkinsons Disease Rating Scale, Part III
Description: most recent, internationally standardized examination/quantification of bradykinesia / rigidity according to the Movement Disorder Society

Intervention type: BEHAVIORAL
Intervention: MDS-United Parkinsons Disease Rating Scale, Part III
Description: most recent, internationally standardized examination/quantification of bradykinesia / rigidity according to the Movement Disorder Society

Intervention type: BEHAVIORAL
Intervention: MDS-United Parkinsons Disease Rating Scale, Part III
Description: most recent, internationally standardized examination/quantification of bradykinesia / rigidity according to the Movement Disorder Society

Intervention type: BEHAVIORAL
Intervention: MDS-United Parkinsons Disease Rating Scale, Part III
Description: most recent, internationally standardized examination/quantification of bradykinesia / rigidity according to the Movement Disorder Society

Intervention type: BEHAVIORAL
Intervention: Beck Depression Inventory
Description: internationally standardized examination to quantify traits of anxiety and depression

Intervention type: BEHAVIORAL
Intervention: Beck Depression Inventory
Description: internationally standardized examination to quantify traits of anxiety and depression

Intervention type: BEHAVIORAL
Intervention: Beck Depression Inventory
Description: internationally standardized examination to quantify traits of anxiety and depression

Intervention type: BEHAVIORAL
Intervention: Beck Depression Inventory
Description: internationally standardized examination to quantify traits of anxiety and depression

Intervention type: BEHAVIORAL
Intervention: Beck Depression Inventory
Description: internationally standardized examination to quantify traits of anxiety and depression

Intervention type: BEHAVIORAL
Intervention: Beck Depression Inventory
Description: internationally standardized examination to quantify traits of anxiety and depression

Intervention type: BEHAVIORAL
Intervention: MoCA: Montreal Cognitive Assessment:
Description: internationally standardized examination to quantify cognition, frequently used in studies of dystonia and parkinsonism

Intervention type: BEHAVIORAL
Intervention: MoCA: Montreal Cognitive Assessment:
Description: internationally standardized examination to quantify cognition, frequently used in studies of dystonia and parkinsonism

Intervention type: BEHAVIORAL
Intervention: MoCA: Montreal Cognitive Assessment:
Description: internationally standardized examination to quantify cognition, frequently used in studies of dystonia and parkinsonism

Intervention type: BEHAVIORAL
Intervention: MoCA: Montreal Cognitive Assessment:
Description: internationally standardized examination to quantify cognition, frequently used in studies of dystonia and parkinsonism

Intervention type: BEHAVIORAL
Intervention: MoCA: Montreal Cognitive Assessment:
Description: internationally standardized examination to quantify cognition, frequently used in studies of dystonia and parkinsonism

Intervention type: BEHAVIORAL
Intervention: MoCA: Montreal Cognitive Assessment:
Description: internationally standardized examination to quantify cognition, frequently used in studies of dystonia and parkinsonism