Study: NCT02125786

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Irradiation
Description: Radiation therapy on this protocol will be based on extent of disease, extent of resection and location. The allowed treatment modalities include conformal or intensity-modulated radiation therapy using photons or proton therapy using double-scattering or spot-scanning methods. The general goal is to initiate radiation therapy within 12 weeks of last surgery performed at the time of recurrence.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Irradiation
Description: Radiation therapy on this protocol will be based on extent of disease, extent of resection and location. The allowed treatment modalities include conformal or intensity-modulated radiation therapy using photons or proton therapy using double-scattering or spot-scanning methods. The general goal is to initiate radiation therapy within 12 weeks of last surgery performed at the time of recurrence.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Irradiation
Description: Radiation therapy on this protocol will be based on extent of disease, extent of resection and location. The allowed treatment modalities include conformal or intensity-modulated radiation therapy using photons or proton therapy using double-scattering or spot-scanning methods. The general goal is to initiate radiation therapy within 12 weeks of last surgery performed at the time of recurrence.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Irradiation
Description: Radiation therapy on this protocol will be based on extent of disease, extent of resection and location. The allowed treatment modalities include conformal or intensity-modulated radiation therapy using photons or proton therapy using double-scattering or spot-scanning methods. The general goal is to initiate radiation therapy within 12 weeks of last surgery performed at the time of recurrence.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgery
Description: When applicable, surgery will be used to remove metastases. The goal of surgery is to achieve gross total resection of all imaging visible residual tumor.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgery
Description: When applicable, surgery will be used to remove metastases. The goal of surgery is to achieve gross total resection of all imaging visible residual tumor.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgery
Description: When applicable, surgery will be used to remove metastases. The goal of surgery is to achieve gross total resection of all imaging visible residual tumor.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Surgery
Description: When applicable, surgery will be used to remove metastases. The goal of surgery is to achieve gross total resection of all imaging visible residual tumor.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^8F-Fluorodeoxyglucose
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^8F-Fluorodeoxyglucose
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^8F-Fluorodeoxyglucose
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^8F-Fluorodeoxyglucose
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^1C-methionine
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^1C-methionine
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^1C-methionine
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ^1^1C-methionine
Description: This is a contrast media that will be given intravenously to aid in tumor visualization.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Photon therapy
Description: Participants will receive one or both: Photon or proton therapy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Photon therapy
Description: Participants will receive one or both: Photon or proton therapy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Photon therapy
Description: Participants will receive one or both: Photon or proton therapy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Photon therapy
Description: Participants will receive one or both: Photon or proton therapy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Proton therapy
Description: Participants will receive one or both: Photon or proton therapy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Proton therapy
Description: Participants will receive one or both: Photon or proton therapy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Proton therapy
Description: Participants will receive one or both: Photon or proton therapy.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Proton therapy
Description: Participants will receive one or both: Photon or proton therapy.