Study: NCT00589563

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: anti-thymocyte globulin
Description: 0.5 mg/kg on day -3, 1.5 mg/kg on day -2 and 2.5 mg/kg on day -1 or day 0 from stem cell transplant

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: anti-thymocyte globulin
Description: 0.5 mg/kg on day -3, 1.5 mg/kg on day -2 and 2.5 mg/kg on day -1 or day 0 from stem cell transplant

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: anti-thymocyte globulin
Description: 0.5 mg/kg on day -3, 1.5 mg/kg on day -2 and 2.5 mg/kg on day -1 or day 0 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: cyclophosphamide
Description: 60mg/kg on days -5 and -4 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: etoposide
Description: 60mg/kg on day -4 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: fludarabine phosphate
Description: Fludarabine 25 mg/m2/d from days -9 to -5 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: melphalan
Description: Melphalan 140 mg/m2 on day -4 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: methotrexate
Description: For high risk HLA-mismatch transplant only: 5 mg/m2 on days +1, +3 and +6 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: methotrexate
Description: For high risk HLA-mismatch transplant only: 5 mg/m2 on days +1, +3 and +6 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: methotrexate
Description: For high risk HLA-mismatch transplant only: 5 mg/m2 on days +1, +3 and +6 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sirolimus
Description: Adults: 12 mg loading dose on day -3 from stem cell transplant followed by 4 mg orally single morning daily dose.~Pediatric Patients \<40kg: 3 mg/m2 orally on day -3 from stem cell transplant followed by 1 mg/m2 orally single morning daily dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sirolimus
Description: Adults: 12 mg loading dose on day -3 from stem cell transplant followed by 4 mg orally single morning daily dose.~Pediatric Patients \<40kg: 3 mg/m2 orally on day -3 from stem cell transplant followed by 1 mg/m2 orally single morning daily dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: sirolimus
Description: Adults: 12 mg loading dose on day -3 from stem cell transplant followed by 4 mg orally single morning daily dose.~Pediatric Patients \<40kg: 3 mg/m2 orally on day -3 from stem cell transplant followed by 1 mg/m2 orally single morning daily dose

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: tacrolimus
Description: 0.02 mg/kd/d CIV beginning on day -3 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: tacrolimus
Description: 0.02 mg/kd/d CIV beginning on day -3 from stem cell transplant

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: tacrolimus
Description: 0.02 mg/kd/d CIV beginning on day -3 from stem cell transplant

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: allogeneic hematopoietic stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: allogeneic hematopoietic stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: allogeneic hematopoietic stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: hematopoietic stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: hematopoietic stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: hematopoietic stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Description: Fludarabine 25 mg/m2/d from days -9 to -5 from stem cell transplant, Melphalan 140 mg/m2 on day -4 from stem cell transplant

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Description: Fludarabine 25 mg/m2/d from days -9 to -5 from stem cell transplant, Melphalan 140 mg/m2 on day -4 from stem cell transplant

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: nonmyeloablative allogeneic hematopoietic stem cell transplantation
Description: Fludarabine 25 mg/m2/d from days -9 to -5 from stem cell transplant, Melphalan 140 mg/m2 on day -4 from stem cell transplant

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: peripheral blood stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: peripheral blood stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: peripheral blood stem cell transplantation
Description: The target peripheral blood stem cell dose will be 5-10 x 106/kg actual body weight

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: total-body irradiation
Description: 1320 cGy in 11 fractions from day -8 to day -5 or day -9 to day -6 prior to stem cell transplant

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: total-body irradiation
Description: 1320 cGy in 11 fractions from day -8 to day -5 or day -9 to day -6 prior to stem cell transplant

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: total-body irradiation
Description: 1320 cGy in 11 fractions from day -8 to day -5 or day -9 to day -6 prior to stem cell transplant