Study: NCT04503252

Intervention type: OTHER
Intervention: Blood samples for the measurement of the concentration of cefazolin
Description: Blood samples for the measurement of the concentration of cefazolin will be collected on the 1st (mid-dose and trough sample), 3rd (mid-dose and trough sample),7th and 14th day (for both only trough sample) of cefazolin treatment (+/-1-5 day) and if applicable in weekly intervals during outpatient parenteral antibiotic treatment (usually within 4 weeks after inclusion; only in patients on outpatient continuous parenteral antibiotic treatment).

Intervention type: OTHER
Intervention: Blood samples for the measurement of the concentration of cefazolin
Description: Blood samples for the measurement of the concentration of cefazolin will be collected on the 1st (mid-dose and trough sample), 3rd (mid-dose and trough sample),7th and 14th day (for both only trough sample) of cefazolin treatment (+/-1-5 day) and if applicable in weekly intervals during outpatient parenteral antibiotic treatment (usually within 4 weeks after inclusion; only in patients on outpatient continuous parenteral antibiotic treatment).

Intervention type: OTHER
Intervention: Blood samples for the measurement of the concentration of cefazolin
Description: Blood samples for the measurement of the concentration of cefazolin will be collected on the 1st (mid-dose and trough sample), 3rd (mid-dose and trough sample),7th and 14th day (for both only trough sample) of cefazolin treatment (+/-1-5 day) and if applicable in weekly intervals during outpatient parenteral antibiotic treatment (usually within 4 weeks after inclusion; only in patients on outpatient continuous parenteral antibiotic treatment).

Intervention type: OTHER
Intervention: S. aureus culture isolate
Description: The S. aureus culture isolate will be subjected to exact cefazolin MIC determination and to measurement of the level of cefazolin tolerance.

Intervention type: OTHER
Intervention: S. aureus culture isolate
Description: The S. aureus culture isolate will be subjected to exact cefazolin MIC determination and to measurement of the level of cefazolin tolerance.

Intervention type: OTHER
Intervention: S. aureus culture isolate
Description: The S. aureus culture isolate will be subjected to exact cefazolin MIC determination and to measurement of the level of cefazolin tolerance.

Intervention type: OTHER
Intervention: structured telephone interview
Description: Structured telephone interview for Patient follow- up after 30 days

Intervention type: OTHER
Intervention: structured telephone interview
Description: Structured telephone interview for Patient follow- up after 30 days

Intervention type: OTHER
Intervention: structured telephone interview
Description: Structured telephone interview for Patient follow- up after 30 days

Intervention type: OTHER
Intervention: Sub-study quantitative measurement of Torque Teno virus
Description: An additional EDTA sample will be drawn for quantitative polymerase chain reaction (PCR) of TTV DNA and analyses of cytokines and other parameters of the activation state of the immune system.

Intervention type: OTHER
Intervention: Sub-study investigating cefazolin concentrations in sweat
Description: For each visit of included patients, a sweat sample will be collected via a CE certified Macroduct Sweat Collector. Eccrine sweat glands of the lower forearms are stimulated by pilocarpine (a parasympathomimetic) as well as a local current for 5min. Sweat is subsequently collected by capillary containers during 30min and transferred to small tubes on dry ice. Sweat sample analysis is conducted using mass spectrometry.