Study: NCT02720822

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Treatment with placebo is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Treatment with placebo is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo
Description: Treatment with placebo is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Treatment with placebo is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine Sulfate
Description: Treatment with sustained-release morphine sulfate is given as one double-blind capsule in the morning.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus laxative (Docusate with senna)
Description: If patients are taking morphine, a laxative will be offered. This applies whatever the dose of morphine being taken (8mg, 16mg, 24mg or 32 mg).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus placebo laxative
Description: If the patients are taking placebo, a placebo laxative will be offered.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus placebo laxative
Description: If the patients are taking placebo, a placebo laxative will be offered.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Plus placebo laxative
Description: If the patients are taking placebo, a placebo laxative will be offered.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Plus placebo laxative
Description: If the patients are taking placebo, a placebo laxative will be offered.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: FitBit charge HR (Accelerometer)
Description: A Fitbit will be worn by patients during week 1 and week 3.