Study: NCT01704716

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vincristine
Description: given during Rapid COJEC and modified N7 therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vincristine
Description: given during Rapid COJEC and modified N7 therapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vincristine
Description: given during Rapid COJEC and modified N7 therapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aldesleukin
Description: Aldesleukin is given during MRD Treatment for patients randomised to the arm with IL-2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aldesleukin
Description: Aldesleukin is given during MRD Treatment for patients randomised to the arm with IL-2

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ch14.18/CHO
Description: ch14.18/CHO antibody is given during MRD treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ch14.18/CHO
Description: ch14.18/CHO antibody is given during MRD treatment

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: ch14.18/CHO
Description: ch14.18/CHO antibody is given during MRD treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: ch14.18/CHO
Description: ch14.18/CHO antibody is given during MRD treatment

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carboplatin
Description: Carboplatin is given during induction Treatment (R3 randomisation: Rapid COJEC arm)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Carboplatin is given during induction Treatment (R3 randomisation: Rapid COJEC arm)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Carboplatin is given during induction Treatment (R3 randomisation: Rapid COJEC arm)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Carboplatin
Description: Carboplatin is given during induction Treatment (R3 randomisation: Rapid COJEC arm)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Etoposide
Description: Etoposide is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etoposide
Description: Etoposide is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etoposide
Description: Etoposide is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Etoposide
Description: Etoposide is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etoposide
Description: Etoposide is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cisplatin
Description: Cisplatin is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Cisplatin is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cisplatin
Description: Cisplatin is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Cisplatin is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclophosphamide
Description: Cyclophosphamid is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamid is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclophosphamide
Description: Cyclophosphamid is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamid is given during Induction Treatment (both R3 randomisation arms)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Doxorubicin
Description: Doxorubicin is given during Induction Treatment (R3 arm modified N7)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: G-CSF
Description: G-CSF is given during Induction Treatment

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Busulfan
Description: In case i.v. busulfan is not available, the use of oral busulfan is permitted, although not recommended.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Melphalan
Description: Melphalan is given during MAT treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Melphalan
Description: Melphalan is given during MAT treatment