Study: NCT02865434

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Tc99m-tilmanocept
Description: Tilmanocept is a radiotracer that accumulates in macrophages by binding to a mannose binding receptor that resides on the surface.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 60 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: SPECT Imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 1-9 will receive whole body planar SPECT imaging with 3D SPECT or SPECT/CT for targeted joints of interest 180 Minutes post-injection.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Whole body planar SPECT imaging (15 Minutes post-injection)
Description: Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed 15 minutes post-injection for dosimetry.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Whole body planar SPECT imaging (15 Minutes post-injection)
Description: Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed 15 minutes post-injection for dosimetry.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Whole body planar SPECT imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed 60 minutes post-injection for dosimetry.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Whole body planar SPECT imaging (60 Minutes post-injection)
Description: Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed 60 minutes post-injection for dosimetry.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Whole body planar SPECT imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed 180 minutes post-injection for dosimetry.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Whole body planar SPECT imaging (180 Minutes post-injection)
Description: Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed 180 minutes post-injection for dosimetry.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Whole body planar SPECT imaging (18-20 Hours post-injection)
Description: Subjects enrolled in Groups 10-11 will receive a whole body planar SPECT scan performed 18-20 Hours post-injection for dosimetry.