Study: NCT04043494

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PEG asparaginase
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Protocol Ib\* (Randomization R2)

Intervention type: DRUG
Group type: OTHER
Intervention: PEG asparaginase
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Protocol Ib\* (Randomization R2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: OTHER
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: OTHER
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: OTHER
Intervention: Prednisone
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: OTHER
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: OTHER
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: OTHER
Intervention: Prednisolone
Description: No involvement of CNS: Part of standard chemotherapy. Involvement of CNS: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1), in the experimental treatment phase Protocol Ib\* (Randomization R2) and in the experimental treatment phase Intensified Protocol M (Randomization R2

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thioguanine
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thioguanine
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thioguanine
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: OTHER
Intervention: Thioguanine
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Thioguanine
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: OTHER
Intervention: Thioguanine
Description: Part of standard chemotherapy

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: OTHER
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: OTHER
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: OTHER
Intervention: Vincristine
Description: Part of standard chemotherapy and included in the experimental treatment phase Protocol Ia-Dexamethasone (Randomization R1) and in the experimental treatment phase Intensified Protocol M (Randomization R2)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vindesine
Description: Part of the experimental therapy in Randomization R2 (Intensified Protocol M)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vindesine
Description: Part of the experimental therapy in Randomization R2 (Intensified Protocol M)