Study: NCT02098590

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CPS-immunization
Description: Subjects will be exposed 3 times to bites from 15 NF54 Plasmodium infected mosquitoes during each immunization, while taking chloroquin prophylaxis.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: CPS-immunization
Description: Subjects will be exposed 3 times to bites from 15 NF54 Plasmodium infected mosquitoes during each immunization, while taking chloroquin prophylaxis.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: CPS-immunization
Description: Subjects will be exposed 3 times to bites from 15 NF54 Plasmodium infected mosquitoes during each immunization, while taking chloroquin prophylaxis.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: malaria challenge infection, P. falciparum NF135.C10
Description: Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF135.C10 sporozoites.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: malaria challenge infection, P. falciparum NF135.C10
Description: Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF135.C10 sporozoites.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: malaria challenge infection, P. falciparum NF166.C8
Description: Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF166.C8 sporozoites.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: malaria challenge infection, P. falciparum NF166.C8
Description: Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF166.C8 sporozoites.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: malaria challenge infection, P. falciparum NF54
Description: Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF54 sporozoites.

Intervention type: BIOLOGICAL
Group type: OTHER
Intervention: malaria challenge infection, P. falciparum NF54
Description: Subjects will receive bites from 5 Anopheles mosquitoes infected with Plasmodium falciparum NF54 sporozoites.

Intervention type: DRUG
Group type: OTHER
Intervention: atovaquone/proguanil
Description: All participants will be treated with atovaquone/proguanil when they develop a malaria infection or on day 28 after malaria challenge infection.

Intervention type: DRUG
Group type: OTHER
Intervention: atovaquone/proguanil
Description: All participants will be treated with atovaquone/proguanil when they develop a malaria infection or on day 28 after malaria challenge infection.

Intervention type: DRUG
Group type: OTHER
Intervention: atovaquone/proguanil
Description: All participants will be treated with atovaquone/proguanil when they develop a malaria infection or on day 28 after malaria challenge infection.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: atovaquone/proguanil
Description: All participants will be treated with atovaquone/proguanil when they develop a malaria infection or on day 28 after malaria challenge infection.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: atovaquone/proguanil
Description: All participants will be treated with atovaquone/proguanil when they develop a malaria infection or on day 28 after malaria challenge infection.

Intervention type: DRUG
Group type: OTHER
Intervention: atovaquone/proguanil
Description: All participants will be treated with atovaquone/proguanil when they develop a malaria infection or on day 28 after malaria challenge infection.