Study: NCT02582021

Intervention type: PROCEDURE
Intervention: Coronary Reactivity Testing
Description: An angiography procedure specifically designed to examine the blood vessels in the heart and how they respond to different medications.

Intervention type: PROCEDURE
Intervention: Cardiac Magnetic Resonance Imaging
Description: Noninvasive high resolution imaging test; Optimized magnetic resonance imaging technique for use in the cardiovascular system - use of ECG gating and rapid imaging sequences.~Handgrip, mild leg exercise, and brief Valsalva Maneuver will be conducted to characterize cardiac response to stress. The CMRA is performed as part of the CMRI.

Intervention type: PROCEDURE
Intervention: Cardiac Magnetic Resonance Imaging
Description: Noninvasive high resolution imaging test; Optimized magnetic resonance imaging technique for use in the cardiovascular system - use of ECG gating and rapid imaging sequences.~Handgrip, mild leg exercise, and brief Valsalva Maneuver will be conducted to characterize cardiac response to stress. The CMRA is performed as part of the CMRI.

Intervention type: PROCEDURE
Intervention: Cardiac Magnetic Resonance Angiography
Description: Test for validation purposes against gold-standard Angiography. CMRA is a part of the CMRI test. The residual contrast (gadolinium) circulating in the blood stream (following the CMRI prior images) is sufficient for CMRA evaluation.

Intervention type: PROCEDURE
Intervention: Cardiac Magnetic Resonance Angiography
Description: Test for validation purposes against gold-standard Angiography. CMRA is a part of the CMRI test. The residual contrast (gadolinium) circulating in the blood stream (following the CMRI prior images) is sufficient for CMRA evaluation.

Intervention type: PROCEDURE
Intervention: Computed Coronary Tomographic Angiography
Description: Noninvasive, imaging method that uses a computed tomography (CT) scanner to look at the structures and blood vessels of the heart.

Intervention type: PROCEDURE
Intervention: Rest-Stress Millar Testing
Description: Handgrip, mild leg exercise, and brief Valsalva Maneuver will be conducted to characterize cardiac response to stress. They are designed to test how your heart muscle is functioning.~Rest-stress Millar testing is performed during the coronary angiography and Cardiac Magnetic Resonance Imaging.

Intervention type: PROCEDURE
Intervention: Rest-Stress Millar Testing
Description: Handgrip, mild leg exercise, and brief Valsalva Maneuver will be conducted to characterize cardiac response to stress. They are designed to test how your heart muscle is functioning.~Rest-stress Millar testing is performed during the coronary angiography and Cardiac Magnetic Resonance Imaging.

Intervention type: PROCEDURE
Intervention: Aortic vasorelaxation tests
Description: Non-invasive clinical test. Repeat blood pressure and heart rate per minute will be read for three times; Your pulse wave velocity, pulse wave analysis and central pressure measurements will be recorded.

Intervention type: PROCEDURE
Intervention: Aortic vasorelaxation tests
Description: Non-invasive clinical test. Repeat blood pressure and heart rate per minute will be read for three times; Your pulse wave velocity, pulse wave analysis and central pressure measurements will be recorded.