Study: NCT01601626

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard-dose Lopinavir/Ritonavir
Description: Two LPV 200 mg/RTV 50 mg fixed-dose combination tablets orally twice daily from entry to Week 72.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard-dose Lopinavir/Ritonavir
Description: Two LPV 200 mg/RTV 50 mg fixed-dose combination tablets orally twice daily from entry to Week 72.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Double-dose Lopinavir/Ritonavir
Description: Four LPV 200 mg/RTV 50 mg fixed-dose combination tablets orally twice daily from entry through Week 72.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Raltegravir
Description: One 400 mg tablet orally twice daily from entry to Week 72.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Isoniazid
Description: 300 mg orally once daily from entry through Week 24.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Isoniazid
Description: 300 mg orally once daily from entry through Week 24.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Isoniazid
Description: 300 mg orally once daily from entry through Week 24.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pyridoxine
Description: 25 mg orally once daily from entry to Week 24.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pyridoxine
Description: 25 mg orally once daily from entry to Week 24.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pyridoxine
Description: 25 mg orally once daily from entry to Week 24.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pyrazinamide
Description: 20 to 30 mg/kg orally once daily (not to exceed 2 g per day) from entry through Week 8 study visit (or until completion of intensive TB treatment as determined after dose adjustment in accrual period 1 participants).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pyrazinamide
Description: 20 to 30 mg/kg orally once daily (not to exceed 2 g per day) from entry through Week 8 study visit (or until completion of intensive TB treatment as determined after dose adjustment in accrual period 1 participants).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pyrazinamide
Description: 20 to 30 mg/kg orally once daily (not to exceed 2 g per day) from entry through Week 8 study visit (or until completion of intensive TB treatment as determined after dose adjustment in accrual period 1 participants).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ethambutol
Description: 15 to 20 mg/kg orally once daily from entry through Week 8 study visit (or until completion of intensive TB treatment as determined after dose adjustment in accrual period 1 participants).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ethambutol
Description: 15 to 20 mg/kg orally once daily from entry through Week 8 study visit (or until completion of intensive TB treatment as determined after dose adjustment in accrual period 1 participants).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ethambutol
Description: 15 to 20 mg/kg orally once daily from entry through Week 8 study visit (or until completion of intensive TB treatment as determined after dose adjustment in accrual period 1 participants).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rifabutin
Description: 300 mg of rifabutin orally once until LPV/RTV is started; then the dose will be reduced to 150 mg daily from the start of LPV/RTV through Week 24.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rifabutin
Description: 300 mg of rifabutin orally once until LPV/RTV is started; then the dose will be reduced to 150 mg daily from the start of LPV/RTV through Week 24.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Rifampin
Description: Weight-based dose; for weight \< 45 kg: 450 mg orally once daily; for weight \> 45 kg: 600 mg orally once daily, from entry to week 24.