Study: NCT02954393

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Scaling and root planing
Description: SRP will be performed in four to six appointments lasting approximately 1 h each, using manual curettes (Hu-Friedy, Chicago, IL, USA) and ultrasonic device (Cavitron Select SPC, Dentsply professional, York, PA, USA) under local anesthesia. The deep sites will be scaled throughout the first week and treatment of the entire oral cavity will be completed in 14 days.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Scaling and root planing
Description: SRP will be performed in four to six appointments lasting approximately 1 h each, using manual curettes (Hu-Friedy, Chicago, IL, USA) and ultrasonic device (Cavitron Select SPC, Dentsply professional, York, PA, USA) under local anesthesia. The deep sites will be scaled throughout the first week and treatment of the entire oral cavity will be completed in 14 days.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Scaling and root planing
Description: SRP will be performed in four to six appointments lasting approximately 1 h each, using manual curettes (Hu-Friedy, Chicago, IL, USA) and ultrasonic device (Cavitron Select SPC, Dentsply professional, York, PA, USA) under local anesthesia. The deep sites will be scaled throughout the first week and treatment of the entire oral cavity will be completed in 14 days.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Metronidazole active phase
Description: Metronidazole 400 mg thrice a day for 14 days in the active phase of the periodontal treatment (beginning with the first SRP session).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Metronidazole healing phase
Description: Metronidazole 400 mg thrice a day for 14 days in the healing phase of the periodontal treatment (3 months after active phase).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Amoxicillin active phase
Description: Amoxicillin 500 mg thrice a day for 14 days in the active phase of the periodontal treatment (beginning with the first SRP session).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Amoxicillin healing phase
Description: Amoxicillin 500 mg thrice a day for 14 days in the healing phase of the periodontal treatment (3 months after active phase).

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebos active phase
Description: Amoxicillin and metronidazole placebos thrice a day for 14 days in the active phase (beginning with the first SRP session).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebos active phase
Description: Amoxicillin and metronidazole placebos thrice a day for 14 days in the active phase (beginning with the first SRP session).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebos healing phase
Description: Amoxicillin and metronidazole placebos thrice a day for 14 days in the healing phase (3 months after active phase).

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebos healing phase
Description: Amoxicillin and metronidazole placebos thrice a day for 14 days in the healing phase (3 months after active phase).