Study: NCT00675714

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Stable Isotope Infusion Study
Description: 1-8 hour stable isotope infusion study to be done following each surgery. Tagged isotopes to assess uptake into blood and tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Stable Isotope Infusion Study
Description: 1-8 hour stable isotope infusion study to be done following each surgery. Tagged isotopes to assess uptake into blood and tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Stable Isotope Infusion Study
Description: 1-8 hour stable isotope infusion study to be done following each surgery. Tagged isotopes to assess uptake into blood and tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Collection of blood and tissues
Description: Blood draw with each stable isotope infusion study and weekly Tissue biopsy: skin, fat, muscle at stable isotope infusion study

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Radiology testing: Dual-energy X-ray absorptiometry (DEXA), ultrasound, MRI
Description: Testing to be done following every stable isotope infusion study to measure muscle, fat and bone tissues.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Humatrope
Description: Humatrope (Growth Hormone) dose:0.05mg - 0.2mg/kg/day SQ daily for up to 2 years post burn injury.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ketoconazole
Description: Ketoconazole administration (or other glucocorticoid blocker--itraconazole or fluconazole) PO daily for up to 2 years post burn injury

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oxandrolone
Description: oxandrolone (or other anabolic steroid-testosterone or nandrolone) daily for up to 2 years post burn injury

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Propranolol
Description: Propranolol (or other beta adrenergic blocker--metoprolol, inderol), PO administration daily for up to 2 years post burn injury.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Oxandrolone and propranolol combined
Description: Daily administration of oxandrolone and propranolol to be given for up to 2 years post burn injury.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Humatrope and propranolol combined
Description: Humatrope (growth hormone) and propranolol administration daily for up to 2 years post burn injury.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: placebo to be given once a day for up to two years post burn injury.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Exercise--Hospital supervised intensive exercise program
Description: intensive exercise program supervised by trained personnel in the hospital environment for six up to twelve week program.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Home exercise program
Description: Home intensive exercise program: training occurs in hospital then patient sent home to continue exercise program for six weeks and up to 12 weeks at home.