Study: NCT02570321

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Corneal Cross-linking
Description: For those subjects randomized to receive collagen cross-linking, the procedure will be performed as per the routine at the hospital (UV-X machine; strict aseptic precautions; corneal epithelium debrided and 0.1% riboflavin applied for 30 minutes, then UV-A radiation applied for 30 minutes at 370nm with 3mW/cm2). Corneal cross-linking is a routine procedure performed by Aravind Eye Hospital for infectious keratitis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Corneal Cross-linking
Description: For those subjects randomized to receive collagen cross-linking, the procedure will be performed as per the routine at the hospital (UV-X machine; strict aseptic precautions; corneal epithelium debrided and 0.1% riboflavin applied for 30 minutes, then UV-A radiation applied for 30 minutes at 370nm with 3mW/cm2). Corneal cross-linking is a routine procedure performed by Aravind Eye Hospital for infectious keratitis.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Corneal Cross-linking
Description: For those subjects randomized to receive collagen cross-linking, the procedure will be performed as per the routine at the hospital (UV-X machine; strict aseptic precautions; corneal epithelium debrided and 0.1% riboflavin applied for 30 minutes, then UV-A radiation applied for 30 minutes at 370nm with 3mW/cm2). Corneal cross-linking is a routine procedure performed by Aravind Eye Hospital for infectious keratitis.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Corneal Cross-linking
Description: For those subjects randomized to receive collagen cross-linking, the procedure will be performed as per the routine at the hospital (UV-X machine; strict aseptic precautions; corneal epithelium debrided and 0.1% riboflavin applied for 30 minutes, then UV-A radiation applied for 30 minutes at 370nm with 3mW/cm2). Corneal cross-linking is a routine procedure performed by Aravind Eye Hospital for infectious keratitis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Corneal Cross-linking
Description: For those subjects randomized to receive collagen cross-linking, the procedure will be performed as per the routine at the hospital (UV-X machine; strict aseptic precautions; corneal epithelium debrided and 0.1% riboflavin applied for 30 minutes, then UV-A radiation applied for 30 minutes at 370nm with 3mW/cm2). Corneal cross-linking is a routine procedure performed by Aravind Eye Hospital for infectious keratitis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Corneal Cross-linking
Description: For those subjects randomized to receive collagen cross-linking, the procedure will be performed as per the routine at the hospital (UV-X machine; strict aseptic precautions; corneal epithelium debrided and 0.1% riboflavin applied for 30 minutes, then UV-A radiation applied for 30 minutes at 370nm with 3mW/cm2). Corneal cross-linking is a routine procedure performed by Aravind Eye Hospital for infectious keratitis.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Anti Fungal Drug
Description: Topical Amphotericin B vs Topical Natamycin

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Anti Fungal Drug
Description: Topical Amphotericin B vs Topical Natamycin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anti Fungal Drug
Description: Topical Amphotericin B vs Topical Natamycin

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anti Fungal Drug
Description: Topical Amphotericin B vs Topical Natamycin