Study: NCT04226131

Intervention type: OTHER
Group type: OTHER
Intervention: Muscle Biopsy
Description: After local anesthesia (xylocaine, 2%) is injected, a small incision will be made in the thigh. Four to six small pieces of muscle about the size of a pea will be surgically removed. The incision site will be closed using steri-strips and/or derma-bond, and a light dressing applied.

Intervention type: OTHER
Group type: OTHER
Intervention: Muscle Biopsy
Description: After local anesthesia (xylocaine, 2%) is injected, a small incision will be made in the thigh. Four to six small pieces of muscle about the size of a pea will be surgically removed. The incision site will be closed using steri-strips and/or derma-bond, and a light dressing applied.

Intervention type: OTHER
Group type: OTHER
Intervention: Body Composition
Description: Body composition assessments include circumference measurements and the BOD POD®. Minimal waist circumference measurements will be taken using a tape measure.

Intervention type: OTHER
Group type: OTHER
Intervention: Body Composition
Description: Body composition assessments include circumference measurements and the BOD POD®. Minimal waist circumference measurements will be taken using a tape measure.

Intervention type: OTHER
Group type: OTHER
Intervention: Cardiopulmonary Exercise Test (CPET)
Description: Cardiorespiratory aerobic capacity (VO2 peak), will be assessed using a maximal treadmill test protocol with cardiopulmonary gas exchange. Subjects will be asked to exercise on a treadmill to their perceived maximum ability and effort during which time they will have a mouthpiece in their mouth to determine maximal oxygen use/consumption through breathing. For safety purposes the subject will be monitored by electrocardiogram (ECG) and their blood pressure will be measured at rest and throughout the exercise phase of this test.

Intervention type: OTHER
Group type: OTHER
Intervention: Cardiopulmonary Exercise Test (CPET)
Description: Cardiorespiratory aerobic capacity (VO2 peak), will be assessed using a maximal treadmill test protocol with cardiopulmonary gas exchange. Subjects will be asked to exercise on a treadmill to their perceived maximum ability and effort during which time they will have a mouthpiece in their mouth to determine maximal oxygen use/consumption through breathing. For safety purposes the subject will be monitored by electrocardiogram (ECG) and their blood pressure will be measured at rest and throughout the exercise phase of this test.

Intervention type: OTHER
Group type: OTHER
Intervention: Strength Testing
Description: Strength assessments will include dynamometry-assessed grip and quadriceps strength (Cybex HUMAC NORM, Comp Sports Med, Inc., Stoughton, MA) tests

Intervention type: OTHER
Group type: OTHER
Intervention: Strength Testing
Description: Strength assessments will include dynamometry-assessed grip and quadriceps strength (Cybex HUMAC NORM, Comp Sports Med, Inc., Stoughton, MA) tests

Intervention type: OTHER
Group type: OTHER
Intervention: Questionnaires
Description: Measures include global health, pain, fatigue, physical function, self-efficacy for disease management and sleep.

Intervention type: OTHER
Group type: OTHER
Intervention: Questionnaires
Description: Measures include global health, pain, fatigue, physical function, self-efficacy for disease management and sleep.

Intervention type: OTHER
Group type: OTHER
Intervention: Skeletal Muscle Biomechanical Property Assessment
Description: Passive skeletal muscle stiffness and elasticity measurements of bilateral biceps brachii, flexor carpi radialis, vastus lateralis, and tibialis anterior using mechanical deformation with myotonometry using the MyotonPro device.

Intervention type: OTHER
Group type: OTHER
Intervention: Skeletal Muscle Biomechanical Property Assessment
Description: Passive skeletal muscle stiffness and elasticity measurements of bilateral biceps brachii, flexor carpi radialis, vastus lateralis, and tibialis anterior using mechanical deformation with myotonometry using the MyotonPro device.