Study: NCT01228331

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Amsacrine
Description: one block amsacrine together with etoposide and methylprednisolone for very high risk patients

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Amsacrine
Description: one block amsacrine together with etoposide and methylprednisolone for very high risk patients

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Clofarabine
Description: one block clofarabine with Asparaginase for MRD positive patients after induction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclophosphamide
Description: together wit MTX and ASP in consolidation and together with cytarabine and 6-TG in reinduction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclophosphamide
Description: together wit MTX and ASP in consolidation and together with cytarabine and 6-TG in reinduction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclophosphamide
Description: together wit MTX and ASP in consolidation and together with cytarabine and 6-TG in reinduction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cyclophosphamide
Description: together wit MTX and ASP in consolidation and together with cytarabine and 6-TG in reinduction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cytarabine
Description: part of different chemotherapy blocks in consolidation and reinduction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cytarabine
Description: part of different chemotherapy blocks in consolidation and reinduction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Cytarabine
Description: part of different chemotherapy blocks in consolidation and reinduction

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Daunorubicin hydrochloride
Description: part of induction and reinduction therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Daunorubicin hydrochloride
Description: part of induction and reinduction therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: part of reinduction therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: part of reinduction therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: part of reinduction therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexamethasone
Description: part of reinduction therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Doxorubicin hydrochloride
Description: part of reinduction therapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Etoposide phosphate
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Etoposide phosphate
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Mercaptopurine
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Mercaptopurine
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methotrexate
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methotrexate
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methotrexate
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methotrexate
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methylprednisolone
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methylprednisolone
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pegaspargase
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pegaspargase
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pegaspargase
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pegaspargase
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Thioguanine
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Thioguanine
Description: part of different chemotherapy blocks

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vincristine sulfate
Description: part of intravenous chemotherapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vincristine sulfate
Description: part of intravenous chemotherapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vincristine sulfate
Description: part of intravenous chemotherapy

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vincristine sulfate
Description: part of intravenous chemotherapy

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Whole-brain radiation therapy
Description: patients with initial cns involvement receive cranial irradiation

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: Whole-brain radiation therapy
Description: patients with initial cns involvement receive cranial irradiation