Study: NCT04062201

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Bedaquiline Oral Tablet
Description: Weight Group 16 - 29.9kg: 200mg daily for two weeks; followed by 100mg three times weekly for weeks 3 - 24 Weight Group: 30 - \>50kg: 400mg once daily for 14 days followed by 200mg three times weekly for weeks 3 - 24

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bedaquiline Oral Tablet
Description: Weight Group 16 - 29.9kg: 200mg daily for two weeks; followed by 100mg three times weekly for weeks 3 - 24 Weight Group: 30 - \>50kg: 400mg once daily for 14 days followed by 200mg three times weekly for weeks 3 - 24

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Linezolid Oral Tablet
Description: Weight Group 16 - 23kg: 180 - 210mg (crush 1 tab and mix in 10ml water, administer 3-3.5ml. Discard rest) Weight Group 23.1 - 29.9kg: 300mg daily Weight Group 30 - 33.9kg: 450mg daily Weight Group 34 - \>50kg: 600mg daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Delamanid in Oral Dosage Form
Description: Weight Group 16 - 23kg: 25mg twice daily for 24 weeks Weight Group 23.1 - 33.9kg: 50mg twice daily for 24 weeks Weight Group 34 - \>50kg: 100mg twice daily for 8 weeks followed by 200 mg daily for 16 weeks

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Clofazimine Oral Product
Description: Weight Group 16 - 23kg: 100mg three times a week or 50mg daily Weight Group 23.1 - \>50kg: 100mg daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Levofloxacin Oral Tablet
Description: Weight Group 16 - 23kg: 375 - 500mg daily Weight Group 23.1 - 33.9kg: 500mg once daily Weight Group 34 - 50kg: 750mg daily Weight Group \>50kg:1000mg daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Isoniazid Oral Product
Description: Weight Group 16 - 23kg: 300mg daily Weight Group 23.1 - 50kg: 400mg daily Weight Group \>50kg: 600mg daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Ethambutol Oral Product
Description: Weight Group 16 - 23kg: 400mg daily Weight Group 23.1 - 29.9kg: 600mg daily Weight Group 30 - 50kg: 800mg daily Weight Group \>50kg: 1200mg daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Pyrazinamide Oral Product
Description: Weight Group 16 - 23kg: 750mg daily Weight Group 23.1 - 29.9kg: 1000mg daily Weight Group 30 - 33.9kg: 1250mg daily Weight Group 34 - 50kg: 1500mg daily Weight Group \>50kg: 2000mg daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Linezolid Oral Tablet
Description: Weight Group 16 - 23kg: 180 - 210mg (crush 1 tab and mix in 10ml water, administer 3-3.5ml. Discard rest) Weight Group 23.1 - 29.9kg: 300mg daily Weight Group 30 - 33.9kg: 450mg daily Weight Group 34 - \>50kg: 600mg daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Clofazimine Oral Product
Description: Weight Group 16 - 23kg: 100mg three times a week or 50mg daily Weight Group 23.1 - \>50kg: 100mg daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Levofloxacin Oral Tablet
Description: Weight Group 16 - 23kg: 375 - 500mg daily Weight Group 23.1 - 33.9kg: 500mg once daily Weight Group 34 - 50kg: 750mg daily Weight Group \>50kg:1000mg daily