Study: NCT01847768

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: GMP-grade HRV-39
Description: Experimental rhinovirus infection: an FDA approved, GMP-grade HRV-39 stock (gift from Dr. Ronald B. Turner, University of Virginia), which has now been approved by Health Canada for human experimental use, will be used in this study.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: GMP-grade HRV-39
Description: Experimental rhinovirus infection: an FDA approved, GMP-grade HRV-39 stock (gift from Dr. Ronald B. Turner, University of Virginia), which has now been approved by Health Canada for human experimental use, will be used in this study.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bronchoalveolar Lavage

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Bronchoalveolar Lavage

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methacholine Inhalation Challenge
Description: The purpose of this test is to determine if lung airways narrow by more than 20%, which confirms an asthma diagnosis.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methacholine Inhalation Challenge
Description: The purpose of this test is to determine if lung airways narrow by more than 20%, which confirms an asthma diagnosis.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Nasal Lavage

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Nasal Lavage

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Nasal Scrapings
Description: This process uses a rhinoprobe to gently scrape the mucosal lining of the nose

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Nasal Scrapings
Description: This process uses a rhinoprobe to gently scrape the mucosal lining of the nose

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bronchial Brushings

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Bronchial Brushings

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lung Mucosal Biopsy

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Lung Mucosal Biopsy

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Allergen Skin Prick Testing
Description: For the purposes of this study, allergy skin testing will be done with the following aero-allergens: cat epidermis, dog epidermis, horse, grass mix, tree mix, weed mix, ragweed and house dust mite, along with a histamine positive control and a buffer \& glycerol negative control.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Allergen Skin Prick Testing
Description: For the purposes of this study, allergy skin testing will be done with the following aero-allergens: cat epidermis, dog epidermis, horse, grass mix, tree mix, weed mix, ragweed and house dust mite, along with a histamine positive control and a buffer \& glycerol negative control.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Venipuncture
Description: Peripheral blood for assessment of neutralizing antibodies to HRV-39

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Venipuncture
Description: Peripheral blood for assessment of neutralizing antibodies to HRV-39

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bronchoscopy
Description: A small flexible tube the size of a pencil, with a video-camera built into the tip (called a bronchoscope), will be inserted through the nose or mouth and down into the lungs.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Bronchoscopy
Description: A small flexible tube the size of a pencil, with a video-camera built into the tip (called a bronchoscope), will be inserted through the nose or mouth and down into the lungs.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Spirometry

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Spirometry