Study: NCT02215460

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: FMS full-mouth scaling
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: FMS full-mouth scaling
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: FMS full-mouth scaling
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: FMS full-mouth scaling
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: FMS full-mouth scaling
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: QS quadrant scaling
Description: Participants received oral hygiene instructions and quadrant scaling in 4 weekly sections. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: QS quadrant scaling
Description: Participants received oral hygiene instructions and quadrant scaling in 4 weekly sections. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: QS quadrant scaling
Description: Participants received oral hygiene instructions and quadrant scaling in 4 weekly sections. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: QS quadrant scaling
Description: Participants received oral hygiene instructions and quadrant scaling in 4 weekly sections. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: QS quadrant scaling
Description: Participants received oral hygiene instructions and quadrant scaling in 4 weekly sections. Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FMS chlorhexidine rinse
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 60-day use of 0.12% chlorhexidine mouth rinse (15mL/30 seconds/ 2 times a day). Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: FMS placebo rinse
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 60-day use of placebo mouth rinse (15mL/30 seconds/ 2 times a day). Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FMS azithromycin tablets
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 3-day use of azithromycin tablets (1 tablet/day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: FMS placebo tablets
Description: Participants received oral hygiene instructions and full-mouth scaling within 24 hours followed by a 3-day use of placebo tablets (1 tablet/day). Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QS azithromycin tablets
Description: Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 3-day use of azithromycin tablets (1 tablet/day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: QS placebo tablets
Description: Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 3-day use of placebo tablets (1 tablet/day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: QS chlorhexidine rinse
Description: Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 60-day use of 0.12% chlorhexidine mouth rinse (15mL/30 seconds/2 times a day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: QS placebo rinse
Description: Participants received oral hygiene instructions and full-mouth scaling in 4 weekly sections followed by a 60-day use of 0.12% placebo mouth rinse (15mL/30 seconds/2 times a day). Debridement procedures were carried out Debridement procedures were carried out under local anesthesia with manual Gracey and McCall curettes and Hirschfield files.