Study: NCT03288675

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: aiTBS
Description: In the active aiTBS arm, the patients will receive 100 cycli of thetaburst trains of 2s, separated by an inter-train-interval of 6 seconds, delivered on the left dorsolateral prefrontal cortex (DLPFC; i.e. 3000 pulses per session). On each stimulation day, a given patient will receive 5 sessions with a between-session interval of 15 minutes. The treatment protocol of in total 20 aiTBS sessions will be spread over 4 days (i.e. 60.000 pulses in total). The sham coil has been specifically developed to mimic the real one.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: aiTBS
Description: In the active aiTBS arm, the patients will receive 100 cycli of thetaburst trains of 2s, separated by an inter-train-interval of 6 seconds, delivered on the left dorsolateral prefrontal cortex (DLPFC; i.e. 3000 pulses per session). On each stimulation day, a given patient will receive 5 sessions with a between-session interval of 15 minutes. The treatment protocol of in total 20 aiTBS sessions will be spread over 4 days (i.e. 60.000 pulses in total). The sham coil has been specifically developed to mimic the real one.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: aiTBS
Description: In the active aiTBS arm, the patients will receive 100 cycli of thetaburst trains of 2s, separated by an inter-train-interval of 6 seconds, delivered on the left dorsolateral prefrontal cortex (DLPFC; i.e. 3000 pulses per session). On each stimulation day, a given patient will receive 5 sessions with a between-session interval of 15 minutes. The treatment protocol of in total 20 aiTBS sessions will be spread over 4 days (i.e. 60.000 pulses in total). The sham coil has been specifically developed to mimic the real one.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: aiTBS
Description: In the active aiTBS arm, the patients will receive 100 cycli of thetaburst trains of 2s, separated by an inter-train-interval of 6 seconds, delivered on the left dorsolateral prefrontal cortex (DLPFC; i.e. 3000 pulses per session). On each stimulation day, a given patient will receive 5 sessions with a between-session interval of 15 minutes. The treatment protocol of in total 20 aiTBS sessions will be spread over 4 days (i.e. 60.000 pulses in total). The sham coil has been specifically developed to mimic the real one.

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: CCT
Description: By training working memory processing, the CCT aims at modulating similar prefrontal cortex regions as being stimulated previously by aiTBS, namely the DLPFC. thereby possibly stabilizing clinical effects of aiTBS over time. In total 20 sessions of CCT vs. control training (of approximately 25 minutes per session), will be spread over a period of 4 weeks.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CCT
Description: By training working memory processing, the CCT aims at modulating similar prefrontal cortex regions as being stimulated previously by aiTBS, namely the DLPFC. thereby possibly stabilizing clinical effects of aiTBS over time. In total 20 sessions of CCT vs. control training (of approximately 25 minutes per session), will be spread over a period of 4 weeks.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: SSRI
Description: All patients will be prescribed antidepressant medication (SSRI) again when starting the CCT (vs. control training).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SSRI
Description: All patients will be prescribed antidepressant medication (SSRI) again when starting the CCT (vs. control training).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SSRI
Description: All patients will be prescribed antidepressant medication (SSRI) again when starting the CCT (vs. control training).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: SSRI
Description: All patients will be prescribed antidepressant medication (SSRI) again when starting the CCT (vs. control training).