Study: NCT03475953

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 1 : Regorafenib
Description: A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation (withdrawal of consent, intercurrent illness, unacceptable adverse event or any other changes unacceptable for further treatment, etc.). Patients will be allocated 3 dose levels of Regorafenib following a 3 + 3 design.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 1 : Avelumab
Description: A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation (withdrawal of consent, intercurrent illness, unacceptable adverse event or any other changes unacceptable for further treatment, etc.). Avelumab will be administered on cycle 1 Day 15 as a 1-hour intravenous (IV) infusion (10mg/kg), repeated every two weeks thereafter (ie. Day 1 and Day 15 of each subsequent cycle, as a 1-hour intravenous infusion).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at the RP2D of regorafenib defined in the preliminary phase 1 trial with the same schedule as in the phase I.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2 : Avelumab
Description: Phase 2 : Avelumab - All patients will be treated with avelumab with the same schedule as in the phase 1 trial.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Phase 2: low-dose Regorafenib
Description: Phase 2 : Regorafenib - All patients will be treated at a fixed low-dose of regorafenib of 80 mg/day