Study: NCT01909141

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: induction of ovulation using letrozole-pioglitazone-metformin
Description: induction of ovulation will be done for arm 1 for 3 consecutive cycles unless pregnancy occured.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: induction of ovulation using clomiphene citrate-pioglitazone-metformin
Description: induction of ovulation for arm 2 will be done in 3 consecutive cycles unless pregnancy occured.

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: transvaginal ultrasound
Description: transvaginal ultrasound will be done starting from day 10 and every 48 hours until finding a follicle of \> 18 mm or till day 20 of the cycle

Intervention type: RADIATION
Group type: ACTIVE_COMPARATOR
Intervention: transvaginal ultrasound
Description: transvaginal ultrasound will be done starting from day 10 and every 48 hours until finding a follicle of \> 18 mm or till day 20 of the cycle

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: body mass index (BMI) calculation
Description: BMI will be calculated for all women by dividing the weight in kilograms by the height in meters squared

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: body mass index (BMI) calculation
Description: BMI will be calculated for all women by dividing the weight in kilograms by the height in meters squared

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: day 3: follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), total testosterone
Description: baseline hormonal assay (day 3 FSH, LH, TSH and total testosterone) will be done for all women.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: day 3: follicle stimulating hormone (FSH), luteinizing hormone (LH), thyroid stimulating hormone (TSH), total testosterone
Description: baseline hormonal assay (day 3 FSH, LH, TSH and total testosterone) will be done for all women.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: pretreatment blood urea and serum creatinine
Description: blood urea and serum creatinine will be assayed before stating induction of ovulation to have baseline levels.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: pretreatment blood urea and serum creatinine
Description: blood urea and serum creatinine will be assayed before stating induction of ovulation to have baseline levels.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: serum estradiol (E2) on day 12
Description: serum E2 will be assayed on day 12 of the cycle for all women.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: serum estradiol (E2) on day 12
Description: serum E2 will be assayed on day 12 of the cycle for all women.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: serum progesterone on day 21
Description: serum progesterone will be assayed on day 21 for all women to monitor ovulation.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: serum progesterone on day 21
Description: serum progesterone will be assayed on day 21 for all women to monitor ovulation.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: blood urea and serum creatinine every month
Description: blood urea and serum creatinine will be assayed every month during the treatment period to find out any hazards on kidney functions

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: blood urea and serum creatinine every month
Description: blood urea and serum creatinine will be assayed every month during the treatment period to find out any hazards on kidney functions