Study: NCT02018536

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GSK2336805 30 mg
Description: A single dose of 1 tablet of 30 mg of GSK2336805 taken orally (by mouth) on Day 1 under fasted conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GSK2336805 60 mg
Description: A single dose of 2 tablets of 30 mg ie, 60 mg of GSK2336805 taken orally (by mouth) on Day 1 under fasted conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GSK2336805 120 mg
Description: A single dose of 4 tablets of 30 mg ie, 120 mg of GSK2336805 taken orally (by mouth) on Day 1 under fasted conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (Treatment A)
Description: 1 capsule of TMC435 150 mg taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (Treatment A)
Description: 1 capsule of TMC435 150 mg taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (Treatment A)
Description: 1 capsule of TMC435 150 mg taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (Treatment A)
Description: 1 capsule of TMC435 150 mg taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GSK2336805 60 mg (Treatment B and part of Treatment C and D)
Description: 2 tablets of 30 mg GSK2336805 ie, 60 mg of GSK2336805 taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GSK2336805 60 mg (Treatment B and part of Treatment C and D)
Description: 2 tablets of 30 mg GSK2336805 ie, 60 mg of GSK2336805 taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GSK2336805 60 mg (Treatment B and part of Treatment C and D)
Description: 2 tablets of 30 mg GSK2336805 ie, 60 mg of GSK2336805 taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: GSK2336805 60 mg (Treatment B and part of Treatment C and D)
Description: 2 tablets of 30 mg GSK2336805 ie, 60 mg of GSK2336805 taken once daily orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 100 mg (part of Treatment C)
Description: 1 capsule of TMC435 100 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 100 mg (part of Treatment C)
Description: 1 capsule of TMC435 100 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 100 mg (part of Treatment C)
Description: 1 capsule of TMC435 100 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 100 mg (part of Treatment C)
Description: 1 capsule of TMC435 100 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (part of treatment D)
Description: 1 capsule of TMC435 150 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (part of treatment D)
Description: 1 capsule of TMC435 150 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (part of treatment D)
Description: 1 capsule of TMC435 150 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TMC435 150 mg (part of treatment D)
Description: 1 capsule of TMC435 150 mg taken orally (by mouth) on Days 1 to 7 under fed conditions.