Study: NCT03170544

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo to MK-1092
Description: Placebo to MK-1092, SC, as a single dose

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Dextrose
Description: 20% solution for continuous infusion for the duration of the glucose clamp as needed to maintain blood sugar at pre-clamp target levels.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Insulin
Description: Participants will receive insulin IV, as needed, prior to dosing and clamp initiation and after dosing.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Insulin
Description: Participants will receive insulin IV, as needed, prior to dosing and clamp initiation and after dosing.