Study: NCT03784014

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Ceritinib
Description: Target: ALK, ROS. Ceritinib will be administered orally, 450mg once daily on a continuous basis. A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Capmatinib
Description: Target: MET. Capmatinib will be administered orally, 400mg twice daily on a continuous basis. A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lapatinib
Description: Target: ERBB2, EGFR. Lapatinib will be administered orally, 1500mg once daily on a continuous basis. A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Trametinib
Description: Target: KRAS, NRAS, HRAS, PTPN11, NF1, MAP2K. Trametinib will be administered orally, 2 mg once daily on a continuous basis. A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Trametinib and Dabrafenib
Description: Target: KRAS, NRAS, HRAS, PTPN11, NF1, MAP2K, BRAF. Trametinib will be administered orally, 2mg once daily on a continuous basis. Dabrafenib will be administered orally, 150mg twice daily, on a continuous basis.~A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: COMBINATION_PRODUCT
Group type: EXPERIMENTAL
Intervention: Olaparib and Durvalumab
Description: Target: PDL1, PARP. Olaparib will be administered orally, 300mg twice daily on a continuous basis. Dabrafenib will be administered intraveinously, 1500mg on day 1 every 4 weeks. A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Palbociclib
Description: Target: CDK4, CDK6. Palbociclib will be administered orally, 125mg once daily, 3 weeks on/1 week off.~A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Glasdegib
Description: Target: SMO. Glasdegib will be administered orally, 300 mg once daily on a continuous basis. A treatment cycle consists of 4 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: TAS-120
Description: Target: FGFR. TAS-120 will be administered orally, 20 mg once daily on a continuous basis. A treatment cycle consists of 3 weeks. Treatment may continue until disease progression or study discontinuation.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Next Generation sequencing exome
Description: Both frozentumor material (archived or newly obtained) and blood sample collection will be used for genetic profiling