Study: NCT03400839

Intervention type: DIAGNOSTIC_TEST
Intervention: Daily physical activity levels
Description: Objectively measured physical activity using activity monitors.

Intervention type: DIAGNOSTIC_TEST
Intervention: Daily physical activity levels
Description: Objectively measured physical activity using activity monitors.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6-minute walk test
Description: Assessment of functional exercise capacity.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6-minute walk test
Description: Assessment of functional exercise capacity.

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiopulmonary exercise testing
Description: Assessment of maximal exercise capacity.

Intervention type: DIAGNOSTIC_TEST
Intervention: Cardiopulmonary exercise testing
Description: Assessment of maximal exercise capacity.

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle Function
Description: Assessment of muscle force, muscle endurance and muscle fatigability

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle Function
Description: Assessment of muscle force, muscle endurance and muscle fatigability

Intervention type: DIAGNOSTIC_TEST
Intervention: Lung Function
Description: Assessment of whole-body plethysmography and spirometry.

Intervention type: DIAGNOSTIC_TEST
Intervention: Lung Function
Description: Assessment of whole-body plethysmography and spirometry.

Intervention type: DIAGNOSTIC_TEST
Intervention: Body composition
Description: Assessment of bioelectrical impedance.

Intervention type: DIAGNOSTIC_TEST
Intervention: Body composition
Description: Assessment of bioelectrical impedance.

Intervention type: DIAGNOSTIC_TEST
Intervention: HRQoL - SGRQ-I
Description: Assessment of Health-related quality of life by the Saint-George Respiratory questionnaire (SGRQ-I)

Intervention type: DIAGNOSTIC_TEST
Intervention: Symptoms - UCSD/SOBQ
Description: Assessment of symptoms by the UCSD Short of breath questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: HRQoL - SF36
Description: Assessment of Health-related quality of life by the SF-36 questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: HRQoL - SF36
Description: Assessment of Health-related quality of life by the SF-36 questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: Anxiety and depression
Description: Assessment of anxiety and depression by the Hospital Anxiety And Depression (HADS) Scale

Intervention type: DIAGNOSTIC_TEST
Intervention: Anxiety and depression
Description: Assessment of anxiety and depression by the Hospital Anxiety And Depression (HADS) Scale

Intervention type: DIAGNOSTIC_TEST
Intervention: Symptoms - mMRC
Description: Assessment of symptoms by the modified Medical Research Council (mMRC) scale

Intervention type: DIAGNOSTIC_TEST
Intervention: Sleep quality
Description: Assessment of sleep by the Pitsburg Sleep Quality Index (PSQI)

Intervention type: DIAGNOSTIC_TEST
Intervention: Sleep quality
Description: Assessment of sleep by the Pitsburg Sleep Quality Index (PSQI)

Intervention type: DIAGNOSTIC_TEST
Intervention: Sleepiness
Description: Assessment of sleepiness by the Epworth Sleepiness Scale

Intervention type: DIAGNOSTIC_TEST
Intervention: Sleepiness
Description: Assessment of sleepiness by the Epworth Sleepiness Scale

Intervention type: DIAGNOSTIC_TEST
Intervention: Inflammatory markers and oxidative stress
Description: blood assessment of inflammatory markers: IL-2, IL-10, IL-6, IL-4 e IL-17A, TNF, Interferon-γ, CK and CRP.~Blood assessment of oxidative stress: TRAP, SH, SOD, CAT, PON 1, Gpx, MDA, NOx, FOX and AOPP.

Intervention type: DIAGNOSTIC_TEST
Intervention: Inflammatory markers and oxidative stress
Description: blood assessment of inflammatory markers: IL-2, IL-10, IL-6, IL-4 e IL-17A, TNF, Interferon-γ, CK and CRP.~Blood assessment of oxidative stress: TRAP, SH, SOD, CAT, PON 1, Gpx, MDA, NOx, FOX and AOPP.

Intervention type: DIAGNOSTIC_TEST
Intervention: Functional performance tests
Description: Timed-up-and-go at usual pace (TUGu) and at a fast pace (TUGf), four-metre gait speed test (4MGS), sit-to-stand test using three protocols: 30 seconds (30sec-STS), one minute (1min-STS) and five-repetition (5rep-STS) and Short Physical Performance Balance (SPPB).

Intervention type: DIAGNOSTIC_TEST
Intervention: Functional performance tests
Description: Timed-up-and-go at usual pace (TUGu) and at a fast pace (TUGf), four-metre gait speed test (4MGS), sit-to-stand test using three protocols: 30 seconds (30sec-STS), one minute (1min-STS) and five-repetition (5rep-STS) and Short Physical Performance Balance (SPPB).