Study: NCT03275363

Intervention type: DIAGNOSTIC_TEST
Intervention: Neurocognitive battery
Description: Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).~NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.

Intervention type: DIAGNOSTIC_TEST
Intervention: Neurocognitive battery
Description: Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).~NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.

Intervention type: DIAGNOSTIC_TEST
Intervention: Neurocognitive battery
Description: Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).~NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.

Intervention type: DIAGNOSTIC_TEST
Intervention: Neurocognitive battery
Description: Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).~NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.

Intervention type: DIAGNOSTIC_TEST
Intervention: Neurocognitive battery
Description: Cognitive impairment status (SCD, MCI, dementia), HK-MoCA, Clinical Dementia Rating (CDR sum of squares), Geriatric Depression Scale (GDS-15), Neuropsychiatric Index (NPI), Barthel Index, Lawton's IADL, Life-Space Assessment, Mini-Nutrition Assessment (MNA), Quality of Life for Alzheimer's Disease (QoL-AD, patient and carer parts), frailty status (FRAIL scale), handgrip strength, walking speed, exercise status, sleep quality, Charlson comorbidity index (CCI, age-adjusted).~NACC: Story recall, Benson's complex figure copy, colour trail test (black \& white), verbal fluency, digit forward and backward span.

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI
Description: MRI: T1, T2, FLAIR, SWI, DTI, fMRI, ASL, MRS, for selected patients

Intervention type: BIOLOGICAL
Intervention: Blood tests
Description: Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis

Intervention type: BIOLOGICAL
Intervention: Blood tests
Description: Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis

Intervention type: BIOLOGICAL
Intervention: Blood tests
Description: Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis

Intervention type: BIOLOGICAL
Intervention: Blood tests
Description: Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis

Intervention type: BIOLOGICAL
Intervention: Blood tests
Description: Stored samples (unanalysed): serum, plasma, buffy coat (PBMC); also processed for microvesicles and exosome analysis

Intervention type: DIAGNOSTIC_TEST
Intervention: EEG with event-related potential (ERP)
Description: 128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: EEG with event-related potential (ERP)
Description: 128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: EEG with event-related potential (ERP)
Description: 128-channel EEG with ERP for Go/NoGo and Prospective Memory (PM) tasks for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: Amyloid PET CT
Description: F18 Flutametamol PET CT for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: Amyloid PET CT
Description: F18 Flutametamol PET CT for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: Amyloid PET CT
Description: F18 Flutametamol PET CT for selected patients

Intervention type: DIAGNOSTIC_TEST
Intervention: Amyloid PET CT
Description: F18 Flutametamol PET CT for selected patients