Study: NCT00153634

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV amikacin
Description: 5-7.5 mg/kg every 8 hrs or previous dose; start at previous recent stable dose then monitor serum levels and adjust dose, if needed, per standard clinical practice at the site

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV amikacin
Description: 5-7.5 mg/kg every 8 hrs or previous dose; start at previous recent stable dose then monitor serum levels and adjust dose, if needed, per standard clinical practice at the site

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PO azithromycin
Description: 250 mg once daily

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: PO azithromycin
Description: 250 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV ceftazidime
Description: 50 mg/kg every 8 hours, up to 2 grams every 8 hours

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV ceftazidime
Description: 50 mg/kg every 8 hours, up to 2 grams every 8 hours

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: PO ciprofloxacin
Description: 500 mg every 12 hours if weight \<50 kg 750 mg every 12 hours if weight ≥50 kg

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: PO ciprofloxacin
Description: 500 mg every 12 hours if weight \<50 kg 750 mg every 12 hours if weight ≥50 kg

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV meropenem
Description: 40 mg/kg every 8 hours, up to 2 grams every 8 hours

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV meropenem
Description: 40 mg/kg every 8 hours, up to 2 grams every 8 hours

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV piperacillin-tazobactam
Description: 100 mg/kg of piperacillin component every 6 hours, up to 3 grams every 6 hours; antibiotic combination formulated in a fixed ratio, thus dosing is described for first component only

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV piperacillin-tazobactam
Description: 100 mg/kg of piperacillin component every 6 hours, up to 3 grams every 6 hours; antibiotic combination formulated in a fixed ratio, thus dosing is described for first component only

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV ticarcillin-clavulanate
Description: 100 mg/kg of ticarcillin component every 6 hours, up to 3 grams every 6 hours; antibiotic combination formulated in a fixed ratio, thus dosing is described for first component only

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV ticarcillin-clavulanate
Description: 100 mg/kg of ticarcillin component every 6 hours, up to 3 grams every 6 hours; antibiotic combination formulated in a fixed ratio, thus dosing is described for first component only

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: IV tobramycin
Description: 2.5-3.3 mg/kg every 8 hrs or previous dose; start at previous recent stable dose then monitor serum levels and adjust dose, if needed, per standard clinical practice at the site

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: IV tobramycin
Description: 2.5-3.3 mg/kg every 8 hrs or previous dose; start at previous recent stable dose then monitor serum levels and adjust dose, if needed, per standard clinical practice at the site