Study: NCT03860610

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle strength test
Description: Muscle strength in knee flexion and extension and hip abduction will be tested using using a dynamometer (Biodex System 4 Pro: Biodex Medical Systems, Shirley, NY, USA)

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle strength test
Description: Muscle strength in knee flexion and extension and hip abduction will be tested using using a dynamometer (Biodex System 4 Pro: Biodex Medical Systems, Shirley, NY, USA)

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle strength test
Description: Muscle strength in knee flexion and extension and hip abduction will be tested using using a dynamometer (Biodex System 4 Pro: Biodex Medical Systems, Shirley, NY, USA)

Intervention type: DIAGNOSTIC_TEST
Intervention: Dynamic stability test during level and uphill walking
Description: Instrumented gait analysis on an overground walkway with two embedded force plates (Kistler force plate 9260AA6, Kistler AG, Winterthur, Switzerland; sampling rate 2400 Hz) and on a treadmill with an embedded plantar pressure plate (h/p/cosmos, Zebris FDM-T, Isny, Germany)

Intervention type: DIAGNOSTIC_TEST
Intervention: Dynamic stability test during level and uphill walking
Description: Instrumented gait analysis on an overground walkway with two embedded force plates (Kistler force plate 9260AA6, Kistler AG, Winterthur, Switzerland; sampling rate 2400 Hz) and on a treadmill with an embedded plantar pressure plate (h/p/cosmos, Zebris FDM-T, Isny, Germany)

Intervention type: DIAGNOSTIC_TEST
Intervention: Dynamic stability test during level and uphill walking
Description: Instrumented gait analysis on an overground walkway with two embedded force plates (Kistler force plate 9260AA6, Kistler AG, Winterthur, Switzerland; sampling rate 2400 Hz) and on a treadmill with an embedded plantar pressure plate (h/p/cosmos, Zebris FDM-T, Isny, Germany)

Intervention type: DIAGNOSTIC_TEST
Intervention: Dynamic stability test during level and uphill walking
Description: Instrumented gait analysis on an overground walkway with two embedded force plates (Kistler force plate 9260AA6, Kistler AG, Winterthur, Switzerland; sampling rate 2400 Hz) and on a treadmill with an embedded plantar pressure plate (h/p/cosmos, Zebris FDM-T, Isny, Germany)

Intervention type: DIAGNOSTIC_TEST
Intervention: Dynamic stability test during level and uphill walking
Description: Instrumented gait analysis on an overground walkway with two embedded force plates (Kistler force plate 9260AA6, Kistler AG, Winterthur, Switzerland; sampling rate 2400 Hz) and on a treadmill with an embedded plantar pressure plate (h/p/cosmos, Zebris FDM-T, Isny, Germany)

Intervention type: DIAGNOSTIC_TEST
Intervention: Postural stability test
Description: The overall stability index (OSI) will be assessed using the Biodex Balance System SD (Biodex Medical Systems, Inc., Shirley, NY, USA) and is determined by the variance in platform displacement from the horizontal plane.

Intervention type: DIAGNOSTIC_TEST
Intervention: Postural stability test
Description: The overall stability index (OSI) will be assessed using the Biodex Balance System SD (Biodex Medical Systems, Inc., Shirley, NY, USA) and is determined by the variance in platform displacement from the horizontal plane.

Intervention type: DIAGNOSTIC_TEST
Intervention: Postural stability test
Description: The overall stability index (OSI) will be assessed using the Biodex Balance System SD (Biodex Medical Systems, Inc., Shirley, NY, USA) and is determined by the variance in platform displacement from the horizontal plane.

Intervention type: DIAGNOSTIC_TEST
Intervention: Postural stability test
Description: The overall stability index (OSI) will be assessed using the Biodex Balance System SD (Biodex Medical Systems, Inc., Shirley, NY, USA) and is determined by the variance in platform displacement from the horizontal plane.

Intervention type: DIAGNOSTIC_TEST
Intervention: Postural stability test
Description: The overall stability index (OSI) will be assessed using the Biodex Balance System SD (Biodex Medical Systems, Inc., Shirley, NY, USA) and is determined by the variance in platform displacement from the horizontal plane.

Intervention type: DIAGNOSTIC_TEST
Intervention: EuroQol Group Health questionnaire (EQ-5D-5L)
Description: Overall health will be assessed using the EQ-5D-5L health questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: EuroQol Group Health questionnaire (EQ-5D-5L)
Description: Overall health will be assessed using the EQ-5D-5L health questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: EuroQol Group Health questionnaire (EQ-5D-5L)
Description: Overall health will be assessed using the EQ-5D-5L health questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: EuroQol Group Health questionnaire (EQ-5D-5L)
Description: Overall health will be assessed using the EQ-5D-5L health questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: EuroQol Group Health questionnaire (EQ-5D-5L)
Description: Overall health will be assessed using the EQ-5D-5L health questionnaire

Intervention type: DIAGNOSTIC_TEST
Intervention: HOOS/ KOOS
Description: Site specific pain and function will be assessed with the Hip Osteoarthritis Outcome Score (HOOS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) depending on the affected joint (hip or knee).

Intervention type: DIAGNOSTIC_TEST
Intervention: HOOS/ KOOS
Description: Site specific pain and function will be assessed with the Hip Osteoarthritis Outcome Score (HOOS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) depending on the affected joint (hip or knee).

Intervention type: DIAGNOSTIC_TEST
Intervention: HOOS/ KOOS
Description: Site specific pain and function will be assessed with the Hip Osteoarthritis Outcome Score (HOOS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) depending on the affected joint (hip or knee).

Intervention type: DIAGNOSTIC_TEST
Intervention: HOOS/ KOOS
Description: Site specific pain and function will be assessed with the Hip Osteoarthritis Outcome Score (HOOS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) depending on the affected joint (hip or knee).

Intervention type: DIAGNOSTIC_TEST
Intervention: HOOS/ KOOS
Description: Site specific pain and function will be assessed with the Hip Osteoarthritis Outcome Score (HOOS) and Knee Injury and Osteoarthritis Outcome Score (KOOS) depending on the affected joint (hip or knee).

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle activity test
Description: Surface electrodes (Ag/AgCl, Noraxon, U.S.A. Inc., Scottsdale, AZ, USA: 10 mm diameter, 22 mm inter-electrode distance) will be placed bilaterally on glutaeus medius, vastus medialis, semitendinosus, tibialis anterior, gastrocnemius medialis, and peroneus longus muscles. Periods of muscle activity will be defined as intensity above 2 Standard Deviation (SD) of the resting Electromyography (EMG) signal. Duration of overlapping muscle activity between agonists and antagonists normalized to one gait cycle or of a balance test, respectively, will be determined.

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle activity test
Description: Surface electrodes (Ag/AgCl, Noraxon, U.S.A. Inc., Scottsdale, AZ, USA: 10 mm diameter, 22 mm inter-electrode distance) will be placed bilaterally on glutaeus medius, vastus medialis, semitendinosus, tibialis anterior, gastrocnemius medialis, and peroneus longus muscles. Periods of muscle activity will be defined as intensity above 2 Standard Deviation (SD) of the resting Electromyography (EMG) signal. Duration of overlapping muscle activity between agonists and antagonists normalized to one gait cycle or of a balance test, respectively, will be determined.

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle activity test
Description: Surface electrodes (Ag/AgCl, Noraxon, U.S.A. Inc., Scottsdale, AZ, USA: 10 mm diameter, 22 mm inter-electrode distance) will be placed bilaterally on glutaeus medius, vastus medialis, semitendinosus, tibialis anterior, gastrocnemius medialis, and peroneus longus muscles. Periods of muscle activity will be defined as intensity above 2 Standard Deviation (SD) of the resting Electromyography (EMG) signal. Duration of overlapping muscle activity between agonists and antagonists normalized to one gait cycle or of a balance test, respectively, will be determined.

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle activity test
Description: Surface electrodes (Ag/AgCl, Noraxon, U.S.A. Inc., Scottsdale, AZ, USA: 10 mm diameter, 22 mm inter-electrode distance) will be placed bilaterally on glutaeus medius, vastus medialis, semitendinosus, tibialis anterior, gastrocnemius medialis, and peroneus longus muscles. Periods of muscle activity will be defined as intensity above 2 Standard Deviation (SD) of the resting Electromyography (EMG) signal. Duration of overlapping muscle activity between agonists and antagonists normalized to one gait cycle or of a balance test, respectively, will be determined.

Intervention type: DIAGNOSTIC_TEST
Intervention: Muscle activity test
Description: Surface electrodes (Ag/AgCl, Noraxon, U.S.A. Inc., Scottsdale, AZ, USA: 10 mm diameter, 22 mm inter-electrode distance) will be placed bilaterally on glutaeus medius, vastus medialis, semitendinosus, tibialis anterior, gastrocnemius medialis, and peroneus longus muscles. Periods of muscle activity will be defined as intensity above 2 Standard Deviation (SD) of the resting Electromyography (EMG) signal. Duration of overlapping muscle activity between agonists and antagonists normalized to one gait cycle or of a balance test, respectively, will be determined.

Intervention type: DIAGNOSTIC_TEST
Intervention: Passive range of motion
Description: Passive range of motion will be assessed for ankle plantar-/dorsiflexion, knee flexion/extension and hip flexion/extension, ab/adduction, internal/external rotation using goniometers and recorded in degrees. The range between two maxima will be recorded.

Intervention type: DIAGNOSTIC_TEST
Intervention: Passive range of motion
Description: Passive range of motion will be assessed for ankle plantar-/dorsiflexion, knee flexion/extension and hip flexion/extension, ab/adduction, internal/external rotation using goniometers and recorded in degrees. The range between two maxima will be recorded.

Intervention type: DIAGNOSTIC_TEST
Intervention: Passive range of motion
Description: Passive range of motion will be assessed for ankle plantar-/dorsiflexion, knee flexion/extension and hip flexion/extension, ab/adduction, internal/external rotation using goniometers and recorded in degrees. The range between two maxima will be recorded.

Intervention type: DIAGNOSTIC_TEST
Intervention: Passive range of motion
Description: Passive range of motion will be assessed for ankle plantar-/dorsiflexion, knee flexion/extension and hip flexion/extension, ab/adduction, internal/external rotation using goniometers and recorded in degrees. The range between two maxima will be recorded.

Intervention type: DIAGNOSTIC_TEST
Intervention: Passive range of motion
Description: Passive range of motion will be assessed for ankle plantar-/dorsiflexion, knee flexion/extension and hip flexion/extension, ab/adduction, internal/external rotation using goniometers and recorded in degrees. The range between two maxima will be recorded.