TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT03314532

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: TILA-TACE
Description: After femoral artery catheterization, 5-Fr angiography catheters will be used for complete radiography of the celiac artery, the hepatic artery proper, left and right hepatic arteries and their branches, and 2.8-Fr micro-catheters will be used for complete radiography of the tumor's nutrient arteries. Lipiodol-epirubicin emulsions and 5% sodium bicarbonate injection solutions will be used for perfusion of chemotherapy drugs. Different sizes of embolic microspheres will be used alternatively for chemoembolization.
Study: NCT04756973

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: Behavioral weight loss program
Description: A 12 week small group weight loss program delivered via teleconference video technology

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Behavioral weight loss program
Description: A 12 week small group weight loss program delivered via teleconference video technology
Study: NCT03068195

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: microwave ablation
Description: KY2000 microwave ablation system was used in the experimental group. A power output of 60 W for 1-3 min for 1-3 cycles to treat the renal cysts according to the cysts size and classification.Percutaneous microwave ablation will be performed under the guidance of ultrasound while the laparoscopic microwave ablation will be performed under direct vision

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: microwave ablation
Description: KY2000 microwave ablation system was used in the experimental group. A power output of 60 W for 1-3 min for 1-3 cycles to treat the renal cysts according to the cysts size and classification.Percutaneous microwave ablation will be performed under the guidance of ultrasound while the laparoscopic microwave ablation will be performed under direct vision

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: laparoscopic decortication
Description: conventional laparoscopic decortication will be performed to treat the renal cysts
Study: NCT04793308

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Endodontic files
Description: Engine-driven nickel titanium Ni-Ti instruments

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Endodontic files
Description: Engine-driven nickel titanium Ni-Ti instruments
Study: NCT04604392

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rapid Maxillary Expansion Treatment
Description: The patients were treated with KBME, Hyrax and MIDME maxillary expansion appliances, respectively. All expansion appliances containing a Hyrax expansion screw positioned parallel to the second premolars and were used to correct the posterior crossbite. In the MIDME group, two mini-screws with a diameter of 1.6 mm and a length of 10 mm are located on the right and left sides between the roots of the 2nd premolar and 1st molar teeth with 60-70° angle. KBME and Hyrax expansion appliances were cemented with glass ionomer cement and MIDME was cemented with using the light-cured composite. Same protocol was applied to all patients during RME treatment. Expansion screws in all groups were activated by two turns a day.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rapid Maxillary Expansion Treatment
Description: The patients were treated with KBME, Hyrax and MIDME maxillary expansion appliances, respectively. All expansion appliances containing a Hyrax expansion screw positioned parallel to the second premolars and were used to correct the posterior crossbite. In the MIDME group, two mini-screws with a diameter of 1.6 mm and a length of 10 mm are located on the right and left sides between the roots of the 2nd premolar and 1st molar teeth with 60-70° angle. KBME and Hyrax expansion appliances were cemented with glass ionomer cement and MIDME was cemented with using the light-cured composite. Same protocol was applied to all patients during RME treatment. Expansion screws in all groups were activated by two turns a day.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Rapid Maxillary Expansion Treatment
Description: The patients were treated with KBME, Hyrax and MIDME maxillary expansion appliances, respectively. All expansion appliances containing a Hyrax expansion screw positioned parallel to the second premolars and were used to correct the posterior crossbite. In the MIDME group, two mini-screws with a diameter of 1.6 mm and a length of 10 mm are located on the right and left sides between the roots of the 2nd premolar and 1st molar teeth with 60-70° angle. KBME and Hyrax expansion appliances were cemented with glass ionomer cement and MIDME was cemented with using the light-cured composite. Same protocol was applied to all patients during RME treatment. Expansion screws in all groups were activated by two turns a day.
Study: NCT01614717

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: CRT-P Implant
Description: All patients will be implanted with a CRT-P device, then randomized to Treatment or Control Group

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: CRT-P Implant
Description: All patients will be implanted with a CRT-P device, then randomized to Treatment or Control Group
Study: NCT03755557

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Rhinocort
Description: Application of a nasal spray

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Budesolv
Description: Application of a nasal spray

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Application of a nasal spray
Study: NCT01156623

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: EBUS-TBNA
Description: All included patients received TBNA for lymph node study via a flexible ultrasonic bronchoscope with a linear scanning probe on the tip (BF-UC206F-OL8, Olympus). The curved-probe scanned parallel to the insertion direction of bronchoscope, and the obtained images were linked to the ultrasound scanner (EU-2000C, Olympus) incorporated with Doppler-flow imaging. Each lymph node greater than 5mm in short axis measured by cursors was selected for subsequent TBNA with a 22-gauge (NA-201SX-4022, Olympus) needle in a condition of real-time EBUS guidance. A cytology examination was sent for pathologist blinded for the clinical history and image result of patients. When a tissue core was obtained by TBNA, the specimen was also sent for pathology study.
Study: NCT01136356

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: buprenorphine
Description: parenteral buprenorphine may be administered at multiple times each day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: buprenorphine
Description: parenteral buprenorphine may be administered at multiple times each day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: morphine
Description: parenteral morphine may be administered multiple times each day

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: morphine
Description: parenteral morphine may be administered multiple times each day
Study: NCT03334643

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Fiber mix
Description: Participants will test white bread or fiber mix over a span of 2 weeks. During each testing block, each food will be tested twice over two consecutive days. There are 4 testing blocks in total (one for white bread and three for fiber mix).

Intervention type: DIETARY_SUPPLEMENT
Group type: EXPERIMENTAL
Intervention: Fiber mix
Description: Participants will test white bread or fiber mix over a span of 2 weeks. During each testing block, each food will be tested twice over two consecutive days. There are 4 testing blocks in total (one for white bread and three for fiber mix).
Study: NCT03193372

Intervention type: DRUG
Intervention: Azelaic Acid (Finacea Foam, BAY39-6251)
Description: Finacea Foam, Active substance Azelaic acid
Study: NCT02425124

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: PC101+Mental Health
Description: Facility-based stepped care intervention combining stress and depression case detection and management by non-physician clinicians and referral pathways for anti-depressant medication and/or group/individual counselling delivered by lay-health workers for patients with depression.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: PC101+Mental Health
Description: Facility-based stepped care intervention combining stress and depression case detection and management by non-physician clinicians and referral pathways for anti-depressant medication and/or group/individual counselling delivered by lay-health workers for patients with depression.
Study: NCT04724083

Intervention type: DIAGNOSTIC_TEST
Intervention: biomarkers
Description: new diagnostic biomarkers

Intervention type: DIAGNOSTIC_TEST
Intervention: biomarkers
Description: new diagnostic biomarkers

Intervention type: DIAGNOSTIC_TEST
Intervention: biomarkers
Description: new diagnostic biomarkers
Study: NCT00457002

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban
Description: Apixaban: Twice daily, 30 days~Placebo: Once daily, 6-14 days

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Enoxaparin
Description: Enoxaparin: Once daily, 6-14 days~Placebo: Twice daily, 30 days
Study: NCT03494907

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo Matched to Moxifloxacin
Description: Participants will be administered oral dose of moxifloxacin placebo tablet on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Moxifloxacin Dose 1
Description: Participants will be administered oral dose 1 of moxifloxacin on Day 1.
Study: NCT00759681

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: ArterX Surgical Sealant
Description: Apply at the suture site.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Gelfoam and Thrombin
Description: Apply at the suture site.
Study: NCT03667885

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood sample
Description: basic blood sample

Intervention type: DIAGNOSTIC_TEST
Intervention: urine sample
Description: basic urine sample

Intervention type: DIAGNOSTIC_TEST
Intervention: Multi planar MRI
Description: T1 (with reduced affinity for fatty tissue) +/- contrast, diffusion weighted sequences and wash in/wash out
Study: NCT01228890

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: CATCH-IT
Description: The CATCH-IT 2-R intervention has a motivational (3 PCP motivational interviews at time 0, 1.5 months and 12 months and 3 coaching phone calls at 2 and 4 weeks and 18 months) and an Internet component (with separate adolescent \[14 modules\] and parent \[5 modules\] programs). This revised and expanded intervention will include a comprehensive approach to reducing modifiable risk factors and enhancing resiliency factors associated with increased or decreased risk of depression, respectively, proposed by Spence and Reinecke.148 The revised CATCH-IT Tracker will monitor time in study and deploy elements of the intervention based on time since enrollment, including computer and human elements (e.g. calls, doctor visits).

Intervention type: BEHAVIORAL
Group type: ACTIVE_COMPARATOR
Intervention: AMPE
Description: The AMPE components are similar to those employed in previous primary care based quality improvement/Chronic Care Model Interventions (patient education \[psycho-education described below\], provider training \[described in Case Finding and Recruitment\], active monitoring and referral \[case management, discussed under assessments\], physician and nurse education and routine contact with PCP \[study design rationale\]). This Internet site will focus on assisting parents and adolescents in early identification of need for treatment and will also target stigma and negative attitudes toward treatment of mental disorders we have previously identified as barriers to seeking and adhering to treatment.
Study: NCT02531477

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: propofol
Description: intracarotid propofol as an anesthetic agent
Study: NCT03805568

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: dexmedetomidine infusion group
Description: dexmedetomidine as anaesthetic adjuvant

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: remifentanil infusion group
Description: remifentanil as anaesthetic adjuvant
Study: NCT01483963

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AA4500 0.29 mg/1 mL
Description: treatment of adhesive capsulitis

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AA4500 0.58 mg/2 mL
Description: treatment of adhesive capsulitis

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AA4500 0.58 mg/1 mL
Description: treatment of adhesive capsulitis

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: AA4500 0.58 mg/0.5 mL
Description: treatment of adhesive capsulitis

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Shoulder exercises
Description: Home shoulder exercises, minimum of 3 times per day

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Shoulder exercises
Description: Home shoulder exercises, minimum of 3 times per day

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Shoulder exercises
Description: Home shoulder exercises, minimum of 3 times per day

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Shoulder exercises
Description: Home shoulder exercises, minimum of 3 times per day

Intervention type: OTHER
Group type: OTHER
Intervention: Shoulder exercises
Description: Home shoulder exercises, minimum of 3 times per day
Study: NCT01939600

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Amioca
Description: Starch-free breakfast plus 56.4g amioca starch
Study: NCT03741218

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Freeze-dried grape (GRAP)/Placebo (PLA)
Description: The subjects will receive, after overnight fasting, either a monodose of freeze-dried grapes (equivalent to 300 g of fresh grapes) or isocaloric placebo solved in water, together with a high-fat breakfast. Blood samples will be collected before the intake, up to 5 h after breakfast, then a medium-fat lunch will be provided and blood samples will be collected for three additional hours. A total of 10 samples will be collected: 0-30-60-120-180-240-300-330-360-420 min. Both interventions will be separated by two weeks. Subjects will be instructed not to modify their dietary habits during the development of the study, but during the 72 h before each visit they will have to restrict the intake of polyphenol-rich foods (a detailed list will be provided).
Study: NCT03216005

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: BlueLeaf System
Description: The BlueLeaf System will be used to create an autogenous leaflet to mimic valve function.
Study: NCT03860402

Intervention type: OTHER
Intervention: Temperature
Description: temperature of drug
Study: NCT02467062

Intervention type: DEVICE
Group type: OTHER
Intervention: MRI
Description: MRI measurement to evualuate for 4D blood flow pattern

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: MRI
Description: MRI measurement to evualuate for 4D blood flow pattern
Study: NCT00181285

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: High Frequency Chest Wall Oscillator
Description: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax

Intervention type: DEVICE
Group type: SHAM_COMPARATOR
Intervention: High Frequency Chest Wall Oscillator
Description: High velocity, low amplitude oscillatory airflow applied through a pneumatic vest worn over the thorax
Study: NCT02686463

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Laparoscopy
Description: Laparoscopy is an operation performed in the abdomen or pelvis through small incisions (usually 0.5-1.5 cm) with the aid of a camera. It can either be used to inspect and diagnose a condition or to perform surgery.
Study: NCT03083600

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Plant-based Protein Hydrolysate 1
Description: Plant-based Protein Hydrolysate 2 for 12-weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Plant-based Protein Hydrolysate 1
Description: Plant-based Protein Hydrolysate 2 for 12-weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Plant-based Protein Hydrolysate 1
Description: Plant-based Protein Hydrolysate 2 for 12-weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Plant-based Protein Hydrolysate 2
Description: Plant-based Protein Hydrolysate 2 for 12-weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Plant-based Protein Hydrolysate 2
Description: Plant-based Protein Hydrolysate 2 for 12-weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: ACTIVE_COMPARATOR
Intervention: Plant-based Protein Hydrolysate 2
Description: Plant-based Protein Hydrolysate 2 for 12-weeks

Intervention type: DIETARY_SUPPLEMENT
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Cellulose Placebo for 12-weeks
Study: NCT05697393

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Shaker Pressure Band
Study: NCT01669629

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: delefilcon A
Description: Daily wear soft contact lens for bilateral distance vision correction use.
Study: NCT02686463

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Laparotomy
Description: A laparotomy is a surgical procedure involving a large incision through the abdominal wall to gain access into the abdominal cavity. It is also known as a celiotomy.
Study: NCT01669629

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: delefilcon A
Description: Daily wear soft contact lens for bilateral distance vision correction use.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: etafilcon A
Description: Daily wear soft contact lens for bilateral distance vision correction use.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: etafilcon A
Description: Daily wear soft contact lens for bilateral distance vision correction use.
Study: NCT02324439

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Omega Nutrition cold-milled flaxseeds
Description: Patients who are currently in clinical remission will receive a daily 20g dose of cold milled flaxseed as a dietary supplement to determine if this intervention prolongs clinical remission.
Study: NCT02223026

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Linagliptin/metformin FDC

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Linagliptin/metformin FDC

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: high-fat, high caloric meal
Study: NCT02960815

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Intanza

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Mutagrip

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Mutagrip

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aldara

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Aldara
Study: NCT00698022

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Risperidone
Description: risperidone daily for 28 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Risperidone
Description: risperidone daily for 28 days

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Mifepristone
Description: mifepristone daily for 28 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Mifepristone
Description: mifepristone daily for 28 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Risperidone-matched placebo
Description: risperidone-matched placebo daily for 28 days

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Mifepristone-matched placebo
Description: mifepristone-matched placebo daily for 28 days
Study: NCT03218735

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Labor induction at 37.0 weeks to 37.6 weeks of gestation
Description: Diagnosis of LGA with induction at 37 weeks 0 days of gestation to 37 weeks and 6 days

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Expectant monitoring and delivery
Description: Diagnosis of LGA with expectant monitoring and delivery as indicated by standard obstetric practices
Study: NCT04093180

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intensive Neurophysiological Rehabilitation System
Description: Intensive Neurophysiological Rehabilitation System (INRS) is a multicomponent approach that consists of different treatment modalities.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Activity and care as usual
Description: Control group continues usual activity and care while staying in the waiting list.
Study: NCT02350530

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: FOLFOXIRI + Bevacizumab
Description: Bevacizumab 5mg/kg + irinotecan\* 165 mg/m² + oxaliplatin 85 mg/m² + leucovorin 200 mg/m² + 5-FU 2800 mg/m² cont. inf. 46h all on day 1 of each 2 weeks cycle until PD or resectability or to max. 12 cycles

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: FOLFOXIRI
Description: Irinotecan\* 165 mg/m² + oxaliplatin 85 mg/m² + leucovorin 200 mg/m² + 5-FU 2800 mg/m² cont. inf. 46h all on day 1 of each 2 weeks cycle until PD or resectability or to max. 12 cycles
Study: NCT03954561

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: endoscopist-administered abdominal compression
Description: The endoscopist administers abdominal compression when loop formation encountered.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: assistant-administered abdominal compression
Description: A assistant administers abdominal compression when loop formation encountered.
Study: NCT03052166

Intervention type: DEVICE
Intervention: QT Ultrasound scan
Description: QT Ultrasound scan

Intervention type: DEVICE
Intervention: QT Ultrasound scan
Description: QT Ultrasound scan

Intervention type: DEVICE
Intervention: QT Ultrasound scan
Description: QT Ultrasound scan
Study: NCT00439608

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cetuximab,Paclitaxel, Carboplatin
Description: IV treatment for 6 weeks
Study: NCT00887003

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine
Description: Low Volume, Low Dose (5cc, 5mg plain Bupivacaine)

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine
Description: Low Volume, High Dose (5cc, 10mg plain Bupivacaine)
Study: NCT05697393

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Shaker Pressure Band
Study: NCT01440699

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Allogenic human adipose-derived stem cells
Description: ALLO-ASC 1xE7 cells/mL is injected once along the fistula. If there is no safety issue for 4 weeks, 3 more people could be enrolled who are subject to ALLO-ASC 3xE7 cells/mL.
Study: NCT02530307

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: HT-3951

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Study: NCT02969889

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Airtraq
Description: video laryngoscope with a channel

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Airtraq
Description: video laryngoscope with a channel

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: ILMA

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: ILMA