Study: NCT02464176

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: A lumbar plexus nerve block will be performed for patients undergoing hip arthroplasty. A total of 25cc's of 0.25% bupivacaine with 1:400,000 epinephrine will be administered for postoperative analgesia. Surgical anesthesia will be provided either by an intrathecal spinal block or general anesthesia. Successful blockade will be assumed if the patient has a decrease or loss of pinprick sensation in the femoral nerve distribution, which innervates the anterior thigh. If no evidence of blockade is present, testing will occur again at 30 minutes post block. Testing will be performed with a 25 gauge Whitacre needle and once present the area of testing will be marked with a surgical marking pen so that repeat sensory testing can be undertaken at that same site over the course of the study. The subjects will then receive dexamethasone (4 or 8 mg) or placebo (saline) based on arm placement.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: A lumbar plexus nerve block will be performed for patients undergoing hip arthroplasty. A total of 25cc's of 0.25% bupivacaine with 1:400,000 epinephrine will be administered for postoperative analgesia. Surgical anesthesia will be provided either by an intrathecal spinal block or general anesthesia. Successful blockade will be assumed if the patient has a decrease or loss of pinprick sensation in the femoral nerve distribution, which innervates the anterior thigh. If no evidence of blockade is present, testing will occur again at 30 minutes post block. Testing will be performed with a 25 gauge Whitacre needle and once present the area of testing will be marked with a surgical marking pen so that repeat sensory testing can be undertaken at that same site over the course of the study. The subjects will then receive dexamethasone (4 or 8 mg) or placebo (saline) based on arm placement.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine
Description: Bupivacaine will be used in lumbar plexus nerve block mixture.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Bupivacaine
Description: Bupivacaine will be used in lumbar plexus nerve block mixture.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Bupivacaine
Description: Bupivacaine will be used in lumbar plexus nerve block mixture.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Epinephrine
Description: Epinephrine will be used in lumbar plexus nerve block mixture.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Epinephrine
Description: Epinephrine will be used in lumbar plexus nerve block mixture.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Epinephrine
Description: Epinephrine will be used in lumbar plexus nerve block mixture.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lumbar Plexus Nerve Block
Description: This is the procedure that will be performed.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Lumbar Plexus Nerve Block
Description: This is the procedure that will be performed.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Lumbar Plexus Nerve Block
Description: This is the procedure that will be performed.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline
Description: Patients randomized to the placebo group will receive normal saline intravenously.