Study: NCT03206957

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Funduscopic examination and retinal photography
Description: A standardized funduscopic examination and retinal photography will be performed by an ophthalmologist focusing on optic nerve.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Funduscopic examination and retinal photography
Description: A standardized funduscopic examination and retinal photography will be performed by an ophthalmologist focusing on optic nerve.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Funduscopic examination and retinal photography
Description: A standardized funduscopic examination and retinal photography will be performed by an ophthalmologist focusing on optic nerve.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Funduscopic examination and retinal photography
Description: A standardized funduscopic examination and retinal photography will be performed by an ophthalmologist focusing on optic nerve.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum levels of endostatin and angiogenesis factors
Description: Serum levels of endostatin, angiopoietin and vaso endothelial growth factor will be analyzed

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum levels of endostatin and angiogenesis factors
Description: Serum levels of endostatin, angiopoietin and vaso endothelial growth factor will be analyzed

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Serum levels of endostatin and angiogenesis factors
Description: Serum levels of endostatin, angiopoietin and vaso endothelial growth factor will be analyzed

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Renal and low urinary tract Doppler ultrasound
Description: Measurements of each kidney will include maximum renal bipolar length in a sagittal plane, renal width and thickness in an axial plane perpendicular to each other at the level of renal hilum and cortical thickness. Intensity of corticomedullary differentiation will estimated.~Doppler ultrasound examination will assess renal arterial resistivity indexes

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Renal and low urinary tract Doppler ultrasound
Description: Measurements of each kidney will include maximum renal bipolar length in a sagittal plane, renal width and thickness in an axial plane perpendicular to each other at the level of renal hilum and cortical thickness. Intensity of corticomedullary differentiation will estimated.~Doppler ultrasound examination will assess renal arterial resistivity indexes

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Urinalysis
Description: Urinalysis assessments will include assessments of microalbuminuria and microalbuminuria to creatinuria ratio. A spot urine sample will be collected from first morning void.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Urinalysis
Description: Urinalysis assessments will include assessments of microalbuminuria and microalbuminuria to creatinuria ratio. A spot urine sample will be collected from first morning void.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Anthropometric measures and vitals signs
Description: weight, height and blood pressure will be assessed

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Anthropometric measures and vitals signs
Description: weight, height and blood pressure will be assessed