Study: NCT02252302

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Rest (Sitting on chair)
Description: Study participants will sit on a chair for 60min. This is to simulate physical resting condition.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Rest (Sitting on chair)
Description: Study participants will sit on a chair for 60min. This is to simulate physical resting condition.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Rest (Sitting on chair)
Description: Study participants will sit on a chair for 60min. This is to simulate physical resting condition.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Rest (Sitting on chair)
Description: Study participants will sit on a chair for 60min. This is to simulate physical resting condition.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Cycling exercise
Description: Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Cycling exercise
Description: Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Cycling exercise
Description: Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention.

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Cycling exercise
Description: Study participants will exercise on a cycle ergometer for 45min. Participants will start their 30-min long constant workload exercise test test 60-min after the drug intervention. The exercise test will be set to a resistance of 50% of the maximal wattage that was reached on the graded exercise test on the screening day. The cycling exercise intervention will follow the rest-intervention.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Salbutamol inhalation
Description: Study participants will be exposed to 400ug of salbutamol prior to entering the air pollution chamber.

Intervention type: DRUG
Group type: SHAM_COMPARATOR
Intervention: Salbutamol inhalation
Description: Study participants will be exposed to 400ug of salbutamol prior to entering the air pollution chamber.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Salbutamol inhalation
Description: Study participants will be exposed to 400ug of salbutamol prior to entering the air pollution chamber.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo inhalation
Description: Study participants will inhale a placebo (placebo for salbutamol) prior to entering the air pollution chamber

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo inhalation
Description: Study participants will inhale a placebo (placebo for salbutamol) prior to entering the air pollution chamber

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo inhalation
Description: Study participants will inhale a placebo (placebo for salbutamol) prior to entering the air pollution chamber

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Diesel Exhaust Exposure
Description: Participants will be exposed to PM2.5 of 300 μg/m3

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Diesel Exhaust Exposure
Description: Participants will be exposed to PM2.5 of 300 μg/m3

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Diesel Exhaust Exposure
Description: Participants will be exposed to PM2.5 of 300 μg/m3

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Diesel Exhaust Exposure
Description: Participants will be exposed to PM2.5 of 300 μg/m3

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Filtered air
Description: Participants will be breathing filtered air

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Filtered air
Description: Participants will be breathing filtered air

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Filtered air
Description: Participants will be breathing filtered air

Intervention type: OTHER
Group type: SHAM_COMPARATOR
Intervention: Filtered air
Description: Participants will be breathing filtered air