Study: NCT02711137

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: INCB057643
Description: Initial cohort dose of INCB057643 at the protocol-specified starting dose (Part 1), with subsequent dose escalations based on protocol-specific criteria. The recommended treatment group-specific dose(s) will be taken forward into expansion cohorts (Part 2).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gemcitabine
Description: Standard of Care (SOC) agents

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Paclitaxel
Description: Standard of Care (SOC) agents

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Rucaparib
Description: Standard of Care (SOC) agents