Study: NCT03976271

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Description: For this study, a hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp will be conducted to investigate the effect of hypoglycaemia. This means that subjects will receive an intravenous insulin infusion, at a continuous rate of 60 mU∙m-2∙min-1, as well as glucose 20% w/w intravenously at a variable rate, adjusted by arterial plasma glucose levels, measured at 5 minute intervals.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Description: For this study, a hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp will be conducted to investigate the effect of hypoglycaemia. This means that subjects will receive an intravenous insulin infusion, at a continuous rate of 60 mU∙m-2∙min-1, as well as glucose 20% w/w intravenously at a variable rate, adjusted by arterial plasma glucose levels, measured at 5 minute intervals.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Description: For this study, a hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp will be conducted to investigate the effect of hypoglycaemia. This means that subjects will receive an intravenous insulin infusion, at a continuous rate of 60 mU∙m-2∙min-1, as well as glucose 20% w/w intravenously at a variable rate, adjusted by arterial plasma glucose levels, measured at 5 minute intervals.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Description: For this study, a hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp will be conducted to investigate the effect of hypoglycaemia. This means that subjects will receive an intravenous insulin infusion, at a continuous rate of 60 mU∙m-2∙min-1, as well as glucose 20% w/w intravenously at a variable rate, adjusted by arterial plasma glucose levels, measured at 5 minute intervals.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Description: For this study, a hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp will be conducted to investigate the effect of hypoglycaemia. This means that subjects will receive an intravenous insulin infusion, at a continuous rate of 60 mU∙m-2∙min-1, as well as glucose 20% w/w intravenously at a variable rate, adjusted by arterial plasma glucose levels, measured at 5 minute intervals.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp
Description: For this study, a hyperinsulinemic normoglycaemic-hypoglycaemic glucose clamp will be conducted to investigate the effect of hypoglycaemia. This means that subjects will receive an intravenous insulin infusion, at a continuous rate of 60 mU∙m-2∙min-1, as well as glucose 20% w/w intravenously at a variable rate, adjusted by arterial plasma glucose levels, measured at 5 minute intervals.