Study: NCT03603171

Intervention type: DIAGNOSTIC_TEST
Intervention: Hand opening time
Description: A simple test to evaluate clinical myotonia: the patient makes a tight fist for 5 seconds, then rapidly open them and the opening time is measured.

Intervention type: DIAGNOSTIC_TEST
Intervention: Hand opening time
Description: A simple test to evaluate clinical myotonia: the patient makes a tight fist for 5 seconds, then rapidly open them and the opening time is measured.

Intervention type: DIAGNOSTIC_TEST
Intervention: Pressure pain threshold
Description: Thresholds for pressure pain were obtained over eight muscles on the left and right side of the body: extensor digitorum communis, deltoid, quadriceps and anterior tibialis. The average value of two measurements will be recorded.

Intervention type: DIAGNOSTIC_TEST
Intervention: Pressure pain threshold
Description: Thresholds for pressure pain were obtained over eight muscles on the left and right side of the body: extensor digitorum communis, deltoid, quadriceps and anterior tibialis. The average value of two measurements will be recorded.

Intervention type: DIAGNOSTIC_TEST
Intervention: Manual muscle testing
Description: The patient is instructed to hold the corresponding limb or appropriate body part to be tested at the end of its available range while the practitioner provides opposing manual resistance. The strength is measured by the modified-MRC scale. The average value of two mesurements is considered. The following muscles were assessed: neck flexors and extensors, hip flexors and extensors, knee flexors and extensors, shoulder abductors, elbow flexors and extensors, ankle dorsiflexors and plantar flexors, wrist flexors and Extensors, digit flexors and extensors and thumb abductors.

Intervention type: DIAGNOSTIC_TEST
Intervention: Manual muscle testing
Description: The patient is instructed to hold the corresponding limb or appropriate body part to be tested at the end of its available range while the practitioner provides opposing manual resistance. The strength is measured by the modified-MRC scale. The average value of two mesurements is considered. The following muscles were assessed: neck flexors and extensors, hip flexors and extensors, knee flexors and extensors, shoulder abductors, elbow flexors and extensors, ankle dorsiflexors and plantar flexors, wrist flexors and Extensors, digit flexors and extensors and thumb abductors.

Intervention type: DIAGNOSTIC_TEST
Intervention: Quantitative muscle testing
Description: Strength testing using sophisticated strength measuring devices during an isometric contraction. The average value of two measurements is considered; in case of difference \> 10% between measurements, a third attempt is performed. The following muscles are assessed: neck flexors and extensors, hip flexors and extensors, knee flexors and extensors, shoulder abductors, elbow flexors and extensors, ankle dorsiflexors and plantar flexors, wrist flexors and extensors and digit flexors.

Intervention type: DIAGNOSTIC_TEST
Intervention: Quantitative muscle testing
Description: Strength testing using sophisticated strength measuring devices during an isometric contraction. The average value of two measurements is considered; in case of difference \> 10% between measurements, a third attempt is performed. The following muscles are assessed: neck flexors and extensors, hip flexors and extensors, knee flexors and extensors, shoulder abductors, elbow flexors and extensors, ankle dorsiflexors and plantar flexors, wrist flexors and extensors and digit flexors.

Intervention type: DIAGNOSTIC_TEST
Intervention: Scale for Assessment and Rating of Ataxia
Description: SARA is a clinical scale which assesses a range of different impairments in cerebellar ataxia.