Study: NCT02919579

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Intranasal)
Description: Participants will receive intranasal placebo in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Intranasal)
Description: Participants will receive intranasal placebo in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Intranasal)
Description: Participants will receive intranasal placebo in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Intranasal)
Description: Participants will receive intranasal placebo in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Intranasal)
Description: Participants will receive intranasal placebo in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Intranasal)
Description: Participants will receive intranasal placebo in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Intranasal)
Description: Participants will receive intranasal placebo in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Participants will receive intranasal esketamine in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Participants will receive intranasal esketamine in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Participants will receive intranasal esketamine in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Participants will receive intranasal esketamine in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Participants will receive intranasal esketamine in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Participants will receive intranasal esketamine in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Esketamine
Description: Participants will receive intranasal esketamine in Part A (as per the treatment sequence in period 1,2 and 3) and Part B.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alcohol
Description: Participants will receive oral alcohol in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alcohol
Description: Participants will receive oral alcohol in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alcohol
Description: Participants will receive oral alcohol in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alcohol
Description: Participants will receive oral alcohol in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alcohol
Description: Participants will receive oral alcohol in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Alcohol
Description: Participants will receive oral alcohol in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Oral)
Description: Participants will receive oral placebo in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Oral)
Description: Participants will receive oral placebo in Part A (as per the treatment sequence in period 1,2 and 3).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (Oral)
Description: Participants will receive oral placebo in Part A (as per the treatment sequence in period 1,2 and 3).