Study: NCT00540982

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: lidocaine
Description: 1 mg/kg will be administered to determine metabolic capacity

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vinorelbine ditartrate
Description: Varying doses ranging from 30 mg/m2 to 7.5 mg/m2 will be administered based upon liver function

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vinorelbine ditartrate
Description: Varying doses ranging from 30 mg/m2 to 7.5 mg/m2 will be administered based upon liver function

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vinorelbine ditartrate
Description: Varying doses ranging from 30 mg/m2 to 7.5 mg/m2 will be administered based upon liver function

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vinorelbine ditartrate
Description: Varying doses ranging from 30 mg/m2 to 7.5 mg/m2 will be administered based upon liver function

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: high performance liquid chromatography
Description: Used to determine plasma concentrations of vinorelbine

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: high performance liquid chromatography
Description: Used to determine plasma concentrations of vinorelbine

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: high performance liquid chromatography
Description: Used to determine plasma concentrations of vinorelbine

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: high performance liquid chromatography
Description: Used to determine plasma concentrations of vinorelbine

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: intracellular fluorescence polarization analysis
Description: Used to determine concentration of lidocaine metabolic capacity

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: intracellular fluorescence polarization analysis
Description: Used to determine concentration of lidocaine metabolic capacity

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: intracellular fluorescence polarization analysis
Description: Used to determine concentration of lidocaine metabolic capacity

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: intracellular fluorescence polarization analysis
Description: Used to determine concentration of lidocaine metabolic capacity

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: liquid chromatography
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: liquid chromatography
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: liquid chromatography
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: liquid chromatography
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mass spectrometry
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mass spectrometry
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mass spectrometry
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: mass spectrometry
Description: Used to determine concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pharmacological study
Description: Determination of concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pharmacological study
Description: Determination of concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pharmacological study
Description: Determination of concentrations of vinorelbine and its metabolites

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: pharmacological study
Description: Determination of concentrations of vinorelbine and its metabolites