Study: NCT05992272

Intervention type: BIOLOGICAL
Intervention: fMRI imaging (BOLD)
Description: Will be used to investigate neural correlates of PIT effects by measuring the blood oxygenation level dependent (BOLD) response of neural activation in the mesolimbic system.

Intervention type: BIOLOGICAL
Intervention: fMRI imaging (BOLD)
Description: Will be used to investigate neural correlates of PIT effects by measuring the blood oxygenation level dependent (BOLD) response of neural activation in the mesolimbic system.

Intervention type: BIOLOGICAL
Intervention: sMRI (structure)
Description: Will be used to investigate neural correlates of PIT effects by identifying abnormalities in cortical gray and white matter volume.

Intervention type: BIOLOGICAL
Intervention: sMRI (structure)
Description: Will be used to investigate neural correlates of PIT effects by identifying abnormalities in cortical gray and white matter volume.

Intervention type: BEHAVIORAL
Intervention: Trier Social Stress Test
Description: Will be used to assess the effect of acute stress induction on behavioral and neural PIT effects. The induced stress is generated in a social context, where the participants are asked to prepare a job interview for their dream job and to present it in front of a three-member jury.

Intervention type: BEHAVIORAL
Intervention: Trier Social Stress Test
Description: Will be used to assess the effect of acute stress induction on behavioral and neural PIT effects. The induced stress is generated in a social context, where the participants are asked to prepare a job interview for their dream job and to present it in front of a three-member jury.

Intervention type: BEHAVIORAL
Intervention: PIT paradigm
Description: The paradigm consists of four parts:~In the first part, an instrumental learning task is completed in which subjects must learn which stimuli require a response and which do not. In the second part, a classical (Pavlovian) conditioning task is then completed in which subjects learn by passive viewing which stimuli are associated with certain amounts of money. The third part measures to which instrumental responses (learned in Part 1) are modulated by the presentation of the classically conditioned stimuli (learned in Part 2). At the same time drug-associated stimuli are presented in the background measuring to which extent they conflict with the learned instrumental behavior. In the last part, query trials are implemented in which the participants have to choose between two pictures to assess the relative cue value.

Intervention type: BEHAVIORAL
Intervention: PIT paradigm
Description: The paradigm consists of four parts:~In the first part, an instrumental learning task is completed in which subjects must learn which stimuli require a response and which do not. In the second part, a classical (Pavlovian) conditioning task is then completed in which subjects learn by passive viewing which stimuli are associated with certain amounts of money. The third part measures to which instrumental responses (learned in Part 1) are modulated by the presentation of the classically conditioned stimuli (learned in Part 2). At the same time drug-associated stimuli are presented in the background measuring to which extent they conflict with the learned instrumental behavior. In the last part, query trials are implemented in which the participants have to choose between two pictures to assess the relative cue value.

Intervention type: BEHAVIORAL
Intervention: Counting Stroop task
Description: Will be used to assess interference at stimulus level. Here either one, two, three or four identical digits from 1 to 4 are shown. Number and denotation of digits are either congruent (1, 22, 333, 4444; 88 trials) or incongruent (111, 2222, 3, 4444; 88 trials). Subjects have to indicate how many digits were shown

Intervention type: BEHAVIORAL
Intervention: Counting Stroop task
Description: Will be used to assess interference at stimulus level. Here either one, two, three or four identical digits from 1 to 4 are shown. Number and denotation of digits are either congruent (1, 22, 333, 4444; 88 trials) or incongruent (111, 2222, 3, 4444; 88 trials). Subjects have to indicate how many digits were shown

Intervention type: BEHAVIORAL
Intervention: No-go Simon task
Description: Will be used to measure interference at the response level and response inhibition. We will show arrows either pointing to the left or right. The arrow can either be shown on the left or the right side of the display. In congruent trials, direction and position are the same, whereas they differ in incongruent trials. Participants have to indicate the direction of the arrow and ignore the position.