Study: NCT03063229

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: CGMS (Continuous Glucose Monitoring System)
Description: Participants will wear a CGMS for 7 days to measure their glucose control and pattern over a 7 day period.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: CGMS (Continuous Glucose Monitoring System)
Description: Participants will wear a CGMS for 7 days to measure their glucose control and pattern over a 7 day period.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Questionnaire and Hypo Score
Description: Participants with Type 1 Diabetes will fill in 3 short questionnaires about their Diabetes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Questionnaire and Hypo Score
Description: Participants with Type 1 Diabetes will fill in 3 short questionnaires about their Diabetes.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Mixed Meal Tolerance Test (MMTT)
Description: The patients will under go a test which involves taking 30 minute glucose and C-peptide levels (blood test from a cannula) for 3 hours. They will consume 150ml of a mixed meal supplement drink Fortisip Compact at the start of the 3 hours, after having no morning insulin, breakfast and not eating anything from midnight the night before.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mixed Meal Tolerance Test (MMTT)
Description: The patients will under go a test which involves taking 30 minute glucose and C-peptide levels (blood test from a cannula) for 3 hours. They will consume 150ml of a mixed meal supplement drink Fortisip Compact at the start of the 3 hours, after having no morning insulin, breakfast and not eating anything from midnight the night before.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Mixed Meal Tolerance Test (MMTT)
Description: The patients will under go a test which involves taking 30 minute glucose and C-peptide levels (blood test from a cannula) for 3 hours. They will consume 150ml of a mixed meal supplement drink Fortisip Compact at the start of the 3 hours, after having no morning insulin, breakfast and not eating anything from midnight the night before.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Indirect Calorimetry
Description: During the Meal Tolerance Test, the patients will be resting on a bed in the research facility and breathing normally into a clear plastic hood. The machine connected to the hood (GEM) will analyse their resting energy expenditure from the gases expired in their breath. They will have the hood on for 2 hours.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Indirect Calorimetry
Description: During the Meal Tolerance Test, the patients will be resting on a bed in the research facility and breathing normally into a clear plastic hood. The machine connected to the hood (GEM) will analyse their resting energy expenditure from the gases expired in their breath. They will have the hood on for 2 hours.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Indirect Calorimetry
Description: During the Meal Tolerance Test, the patients will be resting on a bed in the research facility and breathing normally into a clear plastic hood. The machine connected to the hood (GEM) will analyse their resting energy expenditure from the gases expired in their breath. They will have the hood on for 2 hours.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Doubly Labelled Water
Description: The Doubly Labelled water will be prescribed for the participants and they will drink their 100ml dose of the stable isotope. Dose depends on the eight of the participant. The participant will then collect urine samples at home on day 5, 10 and 14 after drinking the water. They will store them in the freezer until they can bring them back to us.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Doubly Labelled Water
Description: The Doubly Labelled water will be prescribed for the participants and they will drink their 100ml dose of the stable isotope. Dose depends on the eight of the participant. The participant will then collect urine samples at home on day 5, 10 and 14 after drinking the water. They will store them in the freezer until they can bring them back to us.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Hepatic Mitochondrial Oxidation breath test
Description: Participants will be given a calculated amount of the stable isotope C-Octanoate, which will be delivered in a water solution. They will then be asked to breath down a small tube into a clear plastic collection bag 10 times over 2 hours.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Hepatic Mitochondrial Oxidation breath test
Description: Participants will be given a calculated amount of the stable isotope C-Octanoate, which will be delivered in a water solution. They will then be asked to breath down a small tube into a clear plastic collection bag 10 times over 2 hours.