Study: NCT01478477

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 6 capsules per day (4.3 g)x 6 months. Supplement should be taken with food once per day. No specific food requirements are needed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 6 capsules per day (4.3 g)x 6 months. Supplement should be taken with food once per day. No specific food requirements are needed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 6 capsules per day (4.3 g)x 6 months. Supplement should be taken with food once per day. No specific food requirements are needed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo
Description: 6 capsules per day (4.3 g)x 6 months. Supplement should be taken with food once per day. No specific food requirements are needed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Clinical assessments
Description: All three instruments will be administered at baseline, at 3 months, 6 months and at additional time intervals when there is a significant change in therapy (discontinuation/switch, pain medication administration) during routine medical oncology visits.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Clinical assessments
Description: All three instruments will be administered at baseline, at 3 months, 6 months and at additional time intervals when there is a significant change in therapy (discontinuation/switch, pain medication administration) during routine medical oncology visits.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Assessment of therapy complications
Description: Severity/grade of reaction according to the NCI Common Terminology Criteria for Adverse Events v4.0 (CTCAE).

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Assessment of therapy complications
Description: Severity/grade of reaction according to the NCI Common Terminology Criteria for Adverse Events v4.0 (CTCAE).

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Magnetic Resonance Imaging
Description: Optional bilateral hand and wrist MRI imaging will be obtained at baseline and at 6 months to eligible patients who have no contraindications to MRI imaging.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Magnetic Resonance Imaging
Description: Optional bilateral hand and wrist MRI imaging will be obtained at baseline and at 6 months to eligible patients who have no contraindications to MRI imaging.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Correlative/special studies
Description: Plasma, RBC, and serum samples from the baseline blood draw will also be stored at -70C for fatty acid and biomarker analyses and repeated at 3 month and 6 month intervals. Samples will be analyzed in batches every 6 months.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Correlative/special studies
Description: Plasma, RBC, and serum samples from the baseline blood draw will also be stored at -70C for fatty acid and biomarker analyses and repeated at 3 month and 6 month intervals. Samples will be analyzed in batches every 6 months.