Study: NCT03269721

Intervention type: BEHAVIORAL
Intervention: Neuropsychological Assessment
Description: Assessments include: Paper and pencil computerized measures of Memory, Language, Visuospatial Function, Executive Functioning-Processing Speed, and Attention

Intervention type: BEHAVIORAL
Intervention: Neuropsychological Assessment
Description: Assessments include: Paper and pencil computerized measures of Memory, Language, Visuospatial Function, Executive Functioning-Processing Speed, and Attention

Intervention type: BEHAVIORAL
Intervention: Neuropsychological Assessment
Description: Assessments include: Paper and pencil computerized measures of Memory, Language, Visuospatial Function, Executive Functioning-Processing Speed, and Attention

Intervention type: PROCEDURE
Intervention: Spirometry
Description: Pre and post bronchodilator spirometry will be administered according to the American Thoracic Society (ATS) guidelines.

Intervention type: PROCEDURE
Intervention: Spirometry
Description: Pre and post bronchodilator spirometry will be administered according to the American Thoracic Society (ATS) guidelines.

Intervention type: PROCEDURE
Intervention: Spirometry
Description: Pre and post bronchodilator spirometry will be administered according to the American Thoracic Society (ATS) guidelines.

Intervention type: PROCEDURE
Intervention: Arterial Blood Gas
Description: Radial artery blood sample will be collected to measure gas exchange hemoglobin; arterial oxygen and carbon dioxide will be examined as potential covariates.

Intervention type: PROCEDURE
Intervention: Arterial Blood Gas
Description: Radial artery blood sample will be collected to measure gas exchange hemoglobin; arterial oxygen and carbon dioxide will be examined as potential covariates.

Intervention type: PROCEDURE
Intervention: Arterial Blood Gas
Description: Radial artery blood sample will be collected to measure gas exchange hemoglobin; arterial oxygen and carbon dioxide will be examined as potential covariates.

Intervention type: PROCEDURE
Intervention: Diffusion Capacity of the Lung for Carbon Monoxide
Description: For measurement of gas exchange in the lung. DLCO adjusted for hemoglobin will be the primary variable of interest and will be examined as a potential covariate.

Intervention type: PROCEDURE
Intervention: Diffusion Capacity of the Lung for Carbon Monoxide
Description: For measurement of gas exchange in the lung. DLCO adjusted for hemoglobin will be the primary variable of interest and will be examined as a potential covariate.

Intervention type: PROCEDURE
Intervention: Diffusion Capacity of the Lung for Carbon Monoxide
Description: For measurement of gas exchange in the lung. DLCO adjusted for hemoglobin will be the primary variable of interest and will be examined as a potential covariate.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 Minute Walk Test
Description: Distance walked in 6 minutes will be the primary outcome.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 Minute Walk Test
Description: Distance walked in 6 minutes will be the primary outcome.

Intervention type: DIAGNOSTIC_TEST
Intervention: 6 Minute Walk Test
Description: Distance walked in 6 minutes will be the primary outcome.

Intervention type: PROCEDURE
Intervention: Systemic Vascular Measures
Description: Carotid artery ultrasound, pulse wave velocity, brachial artery endothelium-dependent flow mediated dilation and endothelium-independent dilation will be measured.

Intervention type: PROCEDURE
Intervention: Systemic Vascular Measures
Description: Carotid artery ultrasound, pulse wave velocity, brachial artery endothelium-dependent flow mediated dilation and endothelium-independent dilation will be measured.