Study: NCT01507597

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.2 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.2 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.2 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: NaCl
Description: Continuous iv. saline infusion (NaCl Isotonic) for 210 minutes. Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: NaCl
Description: Continuous iv. saline infusion (NaCl Isotonic) for 210 minutes. Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: NaCl
Description: Continuous iv. saline infusion (NaCl Isotonic) for 210 minutes. Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.4 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.4 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.4 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.8 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.8 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)

Intervention type: DRUG
Group type: OTHER
Intervention: Native human Glucagon-like Peptide-1 ( GLP-1(7-36))
Description: Continuous iv. infusion of the native gut hormone GLP-1 (0.8 pmol/kg/min) for 210 minutes.~Combined with a step wise glucose clamp using 20% w/w glucose iv. infusion reaching plasma glucose value of 15 mM starting at fasting plasma glucose (30 min per step)