Study: NCT01576523

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - single intravenous dose
Description: A single intravenous dose of C1-esterase inhibitor (Berinert) at 20 units per kg body weight will be administered to all subjects prior to receiving the first dose of subcutaneous C1-esterase inhibitor.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - single intravenous dose
Description: A single intravenous dose of C1-esterase inhibitor (Berinert) at 20 units per kg body weight will be administered to all subjects prior to receiving the first dose of subcutaneous C1-esterase inhibitor.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - single intravenous dose
Description: A single intravenous dose of C1-esterase inhibitor (Berinert) at 20 units per kg body weight will be administered to all subjects prior to receiving the first dose of subcutaneous C1-esterase inhibitor.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - single intravenous dose
Description: A single intravenous dose of C1-esterase inhibitor (Berinert) at 20 units per kg body weight will be administered to all subjects prior to receiving the first dose of subcutaneous C1-esterase inhibitor.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - single intravenous dose
Description: A single intravenous dose of C1-esterase inhibitor (Berinert) at 20 units per kg body weight will be administered to all subjects prior to receiving the first dose of subcutaneous C1-esterase inhibitor.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - single intravenous dose
Description: A single intravenous dose of C1-esterase inhibitor (Berinert) at 20 units per kg body weight will be administered to all subjects prior to receiving the first dose of subcutaneous C1-esterase inhibitor.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous low dose
Description: A low dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous low dose
Description: A low dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous low dose
Description: A low dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous low dose
Description: A low dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous medium dose
Description: A medium dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous medium dose
Description: A medium dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous medium dose
Description: A medium dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous medium dose
Description: A medium dose of C1-esterase inhibitor will be administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous high dose
Description: A high dose of C1-esterase inhibitor will administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous high dose
Description: A high dose of C1-esterase inhibitor will administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous high dose
Description: A high dose of C1-esterase inhibitor will administered subcutaneously twice a week for four weeks.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: C1-esterase inhibitor - subcutaneous high dose
Description: A high dose of C1-esterase inhibitor will administered subcutaneously twice a week for four weeks.