Study: NCT02416765

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 15-hour intervention
Description: Interventions will be conducted in outpatient settings. Subject's usual insulin will be used. Meals will not be standardized. Subjects will be allowed to eat whatever and when they want and will be allowed to drink alcohol. Subjects will be allowed to exercise, but they will be asked to do the same amount and intensity of exercise on all intervention visits. Subjects will be accompanied all the time by a member from the research team during closed-loop visits to implement hormonal infusions.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 15-hour intervention
Description: Interventions will be conducted in outpatient settings. Subject's usual insulin will be used. Meals will not be standardized. Subjects will be allowed to eat whatever and when they want and will be allowed to drink alcohol. Subjects will be allowed to exercise, but they will be asked to do the same amount and intensity of exercise on all intervention visits. Subjects will be accompanied all the time by a member from the research team during closed-loop visits to implement hormonal infusions.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 15-hour intervention
Description: Interventions will be conducted in outpatient settings. Subject's usual insulin will be used. Meals will not be standardized. Subjects will be allowed to eat whatever and when they want and will be allowed to drink alcohol. Subjects will be allowed to exercise, but they will be asked to do the same amount and intensity of exercise on all intervention visits. Subjects will be accompanied all the time by a member from the research team during closed-loop visits to implement hormonal infusions.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 15-hour intervention
Description: Interventions will be conducted in outpatient settings. Subject's usual insulin will be used. Meals will not be standardized. Subjects will be allowed to eat whatever and when they want and will be allowed to drink alcohol. Subjects will be allowed to exercise, but they will be asked to do the same amount and intensity of exercise on all intervention visits. Subjects will be accompanied all the time by a member from the research team during closed-loop visits to implement hormonal infusions.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: 15-hour intervention
Description: Interventions will be conducted in outpatient settings. Subject's usual insulin will be used. Meals will not be standardized. Subjects will be allowed to eat whatever and when they want and will be allowed to drink alcohol. Subjects will be allowed to exercise, but they will be asked to do the same amount and intensity of exercise on all intervention visits. Subjects will be accompanied all the time by a member from the research team during closed-loop visits to implement hormonal infusions.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Insulin (Lispro, Aspart or guilisine)
Description: Patient's usual insulin (Lispro, Aspart or guilisine) will be used in all interventions.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Insulin (Lispro, Aspart or guilisine)
Description: Patient's usual insulin (Lispro, Aspart or guilisine) will be used in all interventions.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Insulin (Lispro, Aspart or guilisine)
Description: Patient's usual insulin (Lispro, Aspart or guilisine) will be used in all interventions.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Insulin (Lispro, Aspart or guilisine)
Description: Patient's usual insulin (Lispro, Aspart or guilisine) will be used in all interventions.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Glucagon (Eli Lilly)
Description: In the dual-hormone CLS interventions, glucagon (Eli Lilly) will be used.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Glucagon (Eli Lilly)
Description: In the dual-hormone CLS interventions, glucagon (Eli Lilly) will be used.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Closed-loop strategy
Description: Every 10 minutes, the glucose level as measured by the real time sensor (Dexcom G4 Platinum, Dexcom) will be entered manually into the computer. The pumps' infusion rate will then be changed manually based on the computer generated recommendation infusion rates. The computer generated recommendations are based on a predictive algorithm.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Closed-loop strategy
Description: Every 10 minutes, the glucose level as measured by the real time sensor (Dexcom G4 Platinum, Dexcom) will be entered manually into the computer. The pumps' infusion rate will then be changed manually based on the computer generated recommendation infusion rates. The computer generated recommendations are based on a predictive algorithm.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Closed-loop strategy
Description: Every 10 minutes, the glucose level as measured by the real time sensor (Dexcom G4 Platinum, Dexcom) will be entered manually into the computer. The pumps' infusion rate will then be changed manually based on the computer generated recommendation infusion rates. The computer generated recommendations are based on a predictive algorithm.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Closed-loop strategy
Description: Every 10 minutes, the glucose level as measured by the real time sensor (Dexcom G4 Platinum, Dexcom) will be entered manually into the computer. The pumps' infusion rate will then be changed manually based on the computer generated recommendation infusion rates. The computer generated recommendations are based on a predictive algorithm.