Study: NCT00437021

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (subcutaneous)
Description: 0.9 percent (weight/volume) sodium chloride injection, United States Pharmacopeia \[Sterile Saline Placebo (SSP)\].

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (subcutaneous)
Description: 0.9 percent (weight/volume) sodium chloride injection, United States Pharmacopeia \[Sterile Saline Placebo (SSP)\].

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (subcutaneous)
Description: 0.9 percent (weight/volume) sodium chloride injection, United States Pharmacopeia \[Sterile Saline Placebo (SSP)\].

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (subcutaneous)
Description: 0.9 percent (weight/volume) sodium chloride injection, United States Pharmacopeia \[Sterile Saline Placebo (SSP)\].

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (subcutaneous)
Description: 0.9 percent (weight/volume) sodium chloride injection, United States Pharmacopeia \[Sterile Saline Placebo (SSP)\].

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Placebo (scarification)
Description: Physiologic normal saline for injection.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (scarification)
Description: Physiologic normal saline for injection.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo (scarification)
Description: Physiologic normal saline for injection.

Intervention type: BIOLOGICAL
Group type: ACTIVE_COMPARATOR
Intervention: Dryvax®
Description: Dryvax® Vaccinia Vaccine (\~10\^5 \[plaque forming units (pfu)/dose\] given via scarification, titer 10\^8 pfu per mL after reconstitution).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Dryvax®
Description: Dryvax® Vaccinia Vaccine (\~10\^5 \[plaque forming units (pfu)/dose\] given via scarification, titer 10\^8 pfu per mL after reconstitution).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: Dryvax®
Description: Dryvax® Vaccinia Vaccine (\~10\^5 \[plaque forming units (pfu)/dose\] given via scarification, titer 10\^8 pfu per mL after reconstitution).

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMVAMUNE®
Description: IMVAMUNE® Vaccinia Vaccine delivered by subcutaneous (SC) route at titer 1X10\^8 Tissue Culture Infections Dose50 per 0.5 mL dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMVAMUNE®
Description: IMVAMUNE® Vaccinia Vaccine delivered by subcutaneous (SC) route at titer 1X10\^8 Tissue Culture Infections Dose50 per 0.5 mL dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMVAMUNE®
Description: IMVAMUNE® Vaccinia Vaccine delivered by subcutaneous (SC) route at titer 1X10\^8 Tissue Culture Infections Dose50 per 0.5 mL dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMVAMUNE®
Description: IMVAMUNE® Vaccinia Vaccine delivered by subcutaneous (SC) route at titer 1X10\^8 Tissue Culture Infections Dose50 per 0.5 mL dose.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IMVAMUNE®
Description: IMVAMUNE® Vaccinia Vaccine delivered by subcutaneous (SC) route at titer 1X10\^8 Tissue Culture Infections Dose50 per 0.5 mL dose.