Study: NCT02388178

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Control toothpaste containing no anti-cavity ingredients
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Control toothpaste containing no anti-cavity ingredients
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Control toothpaste containing no anti-cavity ingredients
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Experimental toothpaste containing fluoride and amino acid (arginine)
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Experimental toothpaste containing fluoride and amino acid (arginine)
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Experimental toothpaste containing fluoride and amino acid (arginine)
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Fluoride toothpaste containing fluoride as the anti-cavity ingredient
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Fluoride toothpaste containing fluoride as the anti-cavity ingredient
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fluoride toothpaste containing fluoride as the anti-cavity ingredient
Description: Brush whole mouth with study toothpaste 2x/day for the 2 week test period. Each brushing routine is 1 minute whole mouth brushing with oral retainer in mouth, spit out toothpaste residue and wait for 1 minute before rinsing with water.