Study: NCT02754609

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gluten micro-challenge
Description: From week 12 to week 24, all participants will start a gluten micro-challenge from 10mg/day for the first 2 weeks escalating over the this period to 50mg/day at the end of week 24.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gluten micro-challenge
Description: From week 12 to week 24, all participants will start a gluten micro-challenge from 10mg/day for the first 2 weeks escalating over the this period to 50mg/day at the end of week 24.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Gluten micro-challenge
Description: From week 12 to week 24, all participants will start a gluten micro-challenge from 10mg/day for the first 2 weeks escalating over the this period to 50mg/day at the end of week 24.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Inadvertent gluten challenge
Description: From week 24 to week 36, all participants will be on gluten 50mg/day and 1g twice weekly.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Inadvertent gluten challenge
Description: From week 24 to week 36, all participants will be on gluten 50mg/day and 1g twice weekly.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Inadvertent gluten challenge
Description: From week 24 to week 36, all participants will be on gluten 50mg/day and 1g twice weekly.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Moderate gluten challenge
Description: From week 36 to week 42, all participants will be on gluten 2g/day.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Moderate gluten challenge
Description: From week 36 to week 42, all participants will be on gluten 2g/day.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Moderate gluten challenge
Description: From week 36 to week 42, all participants will be on gluten 2g/day.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Liberal diet
Description: From week 42, all participants will be unblinded and those who have received hookworm therapy have the option to go on a liberal diet of more than 10g of gluten/day from week 42 to week 94.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Liberal diet
Description: From week 42, all participants will be unblinded and those who have received hookworm therapy have the option to go on a liberal diet of more than 10g of gluten/day from week 42 to week 94.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Necator americanus-hookworm larvae L3-10
Description: A total of 40 participants at week 0 and week 8 will have hookworms L3-10 present in 2-3 drops of water applied to their skin and then covered in a light dressing.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Tabasco® Sauce
Description: Arm: Placebo Comparator: Tabasco® Sauce A total of 10 participants at week 0 and week 8 will have Tabasco® Sauce present in 2-3 drops of water applied to their skin and covered in a light dressing

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Necator americanus-hookworm larvae L3-20
Description: A total of 40 participants at week 0 and week 8 will have hookworms L3-20 present in 2-3 drops of water applied to their skin and then covered in a light dressing.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gluten free diet
Description: From week 0 to week 12, all participants will be on a gluten free diet.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Gluten free diet
Description: From week 0 to week 12, all participants will be on a gluten free diet.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Gluten free diet
Description: From week 0 to week 12, all participants will be on a gluten free diet.