Study: NCT01596764

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Loperamide placebo
Description: 200 ml apple juice

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Loperamide
Description: 20 ml Loperamid-ratiopharm® Lösung (ratiopharm) in 180 ml apple juice containing 4 mg of loperamide hydrochloride (prepared before administration)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Loperamide
Description: 20 ml Loperamid-ratiopharm® Lösung (ratiopharm) in 180 ml apple juice containing 4 mg of loperamide hydrochloride (prepared before administration)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Loperamide
Description: 20 ml Loperamid-ratiopharm® Lösung (ratiopharm) in 180 ml apple juice containing 4 mg of loperamide hydrochloride (prepared before administration)

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Colon Transit
Description: 5 capsules containing radio-opaque markers of different shapes, respectively

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Colon Transit
Description: 5 capsules containing radio-opaque markers of different shapes, respectively

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Colon Transit
Description: 5 capsules containing radio-opaque markers of different shapes, respectively

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Colon Transit
Description: 5 capsules containing radio-opaque markers of different shapes, respectively

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Sulfasalazine
Description: Azulfidine® Tabletten 500 mg (Pharmacia/Pfizer) containing 500 mg immediate release sulfasalazine

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Sulfasalazine
Description: Azulfidine® Tabletten 500 mg (Pharmacia/Pfizer) containing 500 mg immediate release sulfasalazine

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Sulfasalazine
Description: Azulfidine® Tabletten 500 mg (Pharmacia/Pfizer) containing 500 mg immediate release sulfasalazine

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Sulfasalazine
Description: Azulfidine® Tabletten 500 mg (Pharmacia/Pfizer) containing 500 mg immediate release sulfasalazine

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo of MNTX and NLX
Description: Placebo capsule (hard gelatine capsule containing multiple sugar spheres)

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo of MNTX and NLX
Description: Placebo capsule (hard gelatine capsule containing multiple sugar spheres)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Naloxone
Description: Naloxone hydrochloride 20 mg Extended Release Capsule equivalent to 18 mg naloxone (hard gelatine capsule containing a single NLX-ER tablet and multiple sugar spheres)

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Methylnaltrexone
Description: Methylnaltrexone bromide 150 mg extended release capsule equivalent to 122 mg methylnaltrexone (hard gelatine capsule containing multiple MNTX-ER micro tablets)