Study: NCT03469271

Intervention type: DRUG
Group type: OTHER
Intervention: 1,25 (OH)2 D3
Description: 0.25 micrograms, taken daily for eight weeks, orally

Intervention type: DRUG
Group type: OTHER
Intervention: 1,25 (OH)2 D3
Description: 0.25 micrograms, taken daily for eight weeks, orally

Intervention type: OTHER
Group type: OTHER
Intervention: Inspiratory isometric resistance training
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.Participants in the active groups will breathe against a resistance set to generate 30% of maximal inspiratory pressure (PImax).

Intervention type: OTHER
Group type: OTHER
Intervention: Inspiratory isometric resistance training
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.Participants in the active groups will breathe against a resistance set to generate 30% of maximal inspiratory pressure (PImax).

Intervention type: DRUG
Group type: OTHER
Intervention: Oral Placebo
Description: Placebo will be created to mimic the appearance of the study drug

Intervention type: DRUG
Group type: OTHER
Intervention: Oral Placebo
Description: Placebo will be created to mimic the appearance of the study drug

Intervention type: OTHER
Group type: OTHER
Intervention: Sham Inspiratory Isometric Resistance Training
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles. Participants in the sham group will train daily against a resistance set to only 15% PImax.

Intervention type: OTHER
Group type: OTHER
Intervention: Sham Inspiratory Isometric Resistance Training
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles. Participants in the sham group will train daily against a resistance set to only 15% PImax.

Intervention type: DEVICE
Group type: OTHER
Intervention: Threshold Inspiratory Muscle Trainer (IMT)
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.

Intervention type: DEVICE
Group type: OTHER
Intervention: Threshold Inspiratory Muscle Trainer (IMT)
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.

Intervention type: DEVICE
Group type: OTHER
Intervention: Threshold Inspiratory Muscle Trainer (IMT)
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.

Intervention type: DEVICE
Group type: OTHER
Intervention: Threshold Inspiratory Muscle Trainer (IMT)
Description: A small hand-held reusable device to increase muscle strength and endurance through inhalation therapy. Participants will inhale through a valve which provides resistance that increases the work of breathing and exercises the respiratory muscles.