Study: NCT01840501

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (single dose)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) as single doses, starting from 0.1 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (multiple doses)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) once daily, starting with a dose of 5.0 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (multiple doses)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) once daily, starting with a dose of 5.0 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (multiple doses)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) once daily, starting with a dose of 5.0 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (multiple doses)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) once daily, starting with a dose of 5.0 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (multiple doses)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) once daily, starting with a dose of 5.0 mg.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-42721458 (multiple doses)
Description: JNJ-42721458 will be administered subcutaneously (an injection under the skin) once daily, starting with a dose of 5.0 mg.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo (single dose)
Description: Matching placebo will be administered subcutaneously (an injection under the skin) as a single dose in Part 1.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo (multiple doses)
Description: Matching placebo will be administered subcutaneously (an injection under the skin) once daily for 10 days in Part 2.