Study: NCT04412694

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone oral tablet 8mg (Dexamethasone Krka tablets(8mg), Warsaw, Poland).
Description: Preoperative oral dexamathasone supplementation in a single dose of 8mg.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Placebo oral sweetener (Clio tablets, sweetener with a dispenser, Instantina GES, Vienna, Austria).
Description: Preoperative oral supplementation of sweetener in a single dose.

Intervention type: DIAGNOSTIC_TEST
Group type: PLACEBO_COMPARATOR
Intervention: Preoparative blood laboratory tests
Description: Preoperative parameters such as blood count, calcium, inorganic phosphates, albumin, alkaline phosphatase, C reactive protein, procalcitonin, 25-hydroxyvitamin D, fibrinogen, parathormone, magnesium, interleukin 1β, interleukin 6, interleukin 10, thyroid stimulating hormone, free thyroxine, free triiodothyronin will be measured in serum.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Preoparative blood laboratory tests
Description: Preoperative parameters such as blood count, calcium, inorganic phosphates, albumin, alkaline phosphatase, C reactive protein, procalcitonin, 25-hydroxyvitamin D, fibrinogen, parathormone, magnesium, interleukin 1β, interleukin 6, interleukin 10, thyroid stimulating hormone, free thyroxine, free triiodothyronin will be measured in serum.

Intervention type: DIAGNOSTIC_TEST
Group type: PLACEBO_COMPARATOR
Intervention: Postoperative laboratory blood tests at 6 hour
Description: At 6 hour after surgery such parameters as blood count, calcium, inorganic phosphates, albumin, alkaline phosphatase, C reactive protein, procalcitonin, 25-hydroxyvitamin D, fibrinogen, parathormone, magnesium will be measured in serum.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Postoperative laboratory blood tests at 6 hour
Description: At 6 hour after surgery such parameters as blood count, calcium, inorganic phosphates, albumin, alkaline phosphatase, C reactive protein, procalcitonin, 25-hydroxyvitamin D, fibrinogen, parathormone, magnesium will be measured in serum.

Intervention type: DIAGNOSTIC_TEST
Group type: PLACEBO_COMPARATOR
Intervention: Postoperative laboratory blood tests at 24 hour
Description: At 24 hour after surgery such parameters as blood count, calcium, inorganic phosphates, albumin, alkaline phosphatase, C reactive protein, procalcitonin, 25-hydroxyvitamin D, fibrinogen, parathormone, magnesium, interleukin 1β, interleukin 6, interleukin 10 will be measured in serum.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Postoperative laboratory blood tests at 24 hour
Description: At 24 hour after surgery such parameters as blood count, calcium, inorganic phosphates, albumin, alkaline phosphatase, C reactive protein, procalcitonin, 25-hydroxyvitamin D, fibrinogen, parathormone, magnesium, interleukin 1β, interleukin 6, interleukin 10 will be measured in serum.

Intervention type: DIAGNOSTIC_TEST
Group type: PLACEBO_COMPARATOR
Intervention: Postoperative laboratory drainage fluid tests at 24 hour
Description: At 24 hour after surgery such parameters as interleukin 1β, interleukin 6, interleukin 10 will be measured in drainage fluid.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Postoperative laboratory drainage fluid tests at 24 hour
Description: At 24 hour after surgery such parameters as interleukin 1β, interleukin 6, interleukin 10 will be measured in drainage fluid.

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Total thyroidectomy
Description: Patients will undergo total thyroidectomy under general anesthesia.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Total thyroidectomy
Description: Patients will undergo total thyroidectomy under general anesthesia.