Study: NCT02051504

Intervention type: BEHAVIORAL
Intervention: Incremental maximal exercise
Description: The exercise test starts 2-4h after a standardised breakfast. After a 2-min resting period sitting on the cycle ergometer (Excalibur Sport, Lode B.V, Medical Technology, Groningen, Netherlands), the test starts at 30 watts with a 20 watts increment every 2min until exhaustion.

Intervention type: BEHAVIORAL
Intervention: Incremental maximal exercise
Description: The exercise test starts 2-4h after a standardised breakfast. After a 2-min resting period sitting on the cycle ergometer (Excalibur Sport, Lode B.V, Medical Technology, Groningen, Netherlands), the test starts at 30 watts with a 20 watts increment every 2min until exhaustion.

Intervention type: BEHAVIORAL
Intervention: Incremental maximal exercise
Description: The exercise test starts 2-4h after a standardised breakfast. After a 2-min resting period sitting on the cycle ergometer (Excalibur Sport, Lode B.V, Medical Technology, Groningen, Netherlands), the test starts at 30 watts with a 20 watts increment every 2min until exhaustion.

Intervention type: BEHAVIORAL
Intervention: Incremental maximal exercise
Description: The exercise test starts 2-4h after a standardised breakfast. After a 2-min resting period sitting on the cycle ergometer (Excalibur Sport, Lode B.V, Medical Technology, Groningen, Netherlands), the test starts at 30 watts with a 20 watts increment every 2min until exhaustion.

Intervention type: DIETARY_SUPPLEMENT
Intervention: Oral Glucose Tolerance Test
Description: The subjects arrive after an overnight fast and have a 75g Glucose Oral Charge.

Intervention type: DIETARY_SUPPLEMENT
Intervention: Oral Glucose Tolerance Test
Description: The subjects arrive after an overnight fast and have a 75g Glucose Oral Charge.

Intervention type: PROCEDURE
Intervention: Muscle biopsy
Description: A sample of vastus lateralis (less than 150mg) is taken with a specific needle under local anesthesia.

Intervention type: PROCEDURE
Intervention: Muscle biopsy
Description: A sample of vastus lateralis (less than 150mg) is taken with a specific needle under local anesthesia.

Intervention type: PROCEDURE
Intervention: Muscle biopsy
Description: A sample of vastus lateralis (less than 150mg) is taken with a specific needle under local anesthesia.

Intervention type: PROCEDURE
Intervention: Muscle biopsy
Description: A sample of vastus lateralis (less than 150mg) is taken with a specific needle under local anesthesia.

Intervention type: PROCEDURE
Intervention: Combined DLCO-DLNO
Description: Lung carbon monoxide and nitric oxide diffusion capacities are assessed at rest in a sitting position.

Intervention type: PROCEDURE
Intervention: Combined DLCO-DLNO
Description: Lung carbon monoxide and nitric oxide diffusion capacities are assessed at rest in a sitting position.

Intervention type: PROCEDURE
Intervention: Combined DLCO-DLNO
Description: Lung carbon monoxide and nitric oxide diffusion capacities are assessed at rest in a sitting position.

Intervention type: PROCEDURE
Intervention: Combined DLCO-DLNO
Description: Lung carbon monoxide and nitric oxide diffusion capacities are assessed at rest in a sitting position.

Intervention type: PROCEDURE
Intervention: Dual energy X-ray absorptiometry
Description: Body composition is measured using dual energy X-ray absorptiometry at rest.

Intervention type: PROCEDURE
Intervention: Dual energy X-ray absorptiometry
Description: Body composition is measured using dual energy X-ray absorptiometry at rest.

Intervention type: PROCEDURE
Intervention: Dual energy X-ray absorptiometry
Description: Body composition is measured using dual energy X-ray absorptiometry at rest.

Intervention type: PROCEDURE
Intervention: Dual energy X-ray absorptiometry
Description: Body composition is measured using dual energy X-ray absorptiometry at rest.