Study: NCT03058237

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Arbaclofen Placarbil SR
Description: One low dose oral tablet of Arbaclofen Placarbil sustained release (SR) in the fasted state.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype A
Description: One low dose oral tablet pf Arbaclofen Placarbil modified release (MR) Prototype A in the fasted state; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Arbaclofen Placarbil MR Prototype B
Description: One low dose oral tablet of Arbaclofen Placarbil modified release (MR) Prototype B; this formulation may also be tested with 0.6 g/kg beverage diluted in orange juice

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Arbaclofen Placarbil IR
Description: One low dose oral capsule of Arbaclofen Placarbil immediate release (IR) in the fasted state.