Study: NCT04708613

Intervention type: DIAGNOSTIC_TEST
Intervention: Cognitive/Neuropsychological Testing
Description: Comprehensive testing of cognitive function and brain health.

Intervention type: DIAGNOSTIC_TEST
Intervention: Cognitive/Neuropsychological Testing
Description: Comprehensive testing of cognitive function and brain health.

Intervention type: DIAGNOSTIC_TEST
Intervention: Vestibular/Ocular-Motor Testing
Description: A series of tests and questionnaires that asses vestibular function, balance, ocular-motor coordination, and reflexes.

Intervention type: DIAGNOSTIC_TEST
Intervention: Vestibular/Ocular-Motor Testing
Description: A series of tests and questionnaires that asses vestibular function, balance, ocular-motor coordination, and reflexes.

Intervention type: DIAGNOSTIC_TEST
Intervention: Sleep Evaluation
Description: A full assessment of sleep health, including insomnia (duration, frequency, daytime consequences) and other sleep disorders such as obstructive sleep apnea. Overnight sleep study is included.

Intervention type: DIAGNOSTIC_TEST
Intervention: Sleep Evaluation
Description: A full assessment of sleep health, including insomnia (duration, frequency, daytime consequences) and other sleep disorders such as obstructive sleep apnea. Overnight sleep study is included.

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI, High-Resolution
Description: A high-resolution MRI to provide qualitative and quantitative assessments of brain structure.

Intervention type: DIAGNOSTIC_TEST
Intervention: MRI, High-Resolution
Description: A high-resolution MRI to provide qualitative and quantitative assessments of brain structure.

Intervention type: DIAGNOSTIC_TEST
Intervention: Health & Physical Exam
Description: Participants will undergo an executive history and physical exam of all body systems.

Intervention type: DIAGNOSTIC_TEST
Intervention: Health & Physical Exam
Description: Participants will undergo an executive history and physical exam of all body systems.

Intervention type: DIAGNOSTIC_TEST
Intervention: Physical Function
Description: These assessments will involve a series of tests and questionnaires that focus on physical function.

Intervention type: DIAGNOSTIC_TEST
Intervention: Physical Function
Description: These assessments will involve a series of tests and questionnaires that focus on physical function.

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Testing and Biomarker Analysis
Description: A blood draw will be performed to measure standard clinical labs as part of a full history and physical, as well as additional analysis of biomarkers indicative of brain health.~An optional lumbar puncture will be performed and CSF samples (20-30 mL) stored in the NCTC Biorepository until shipment to the CLIA-certified laboratory.~Both CSF and blood samples will be analyzed for t-tau, p-tau, and Aβ42 and stored for future testing,

Intervention type: DIAGNOSTIC_TEST
Intervention: Blood Testing and Biomarker Analysis
Description: A blood draw will be performed to measure standard clinical labs as part of a full history and physical, as well as additional analysis of biomarkers indicative of brain health.~An optional lumbar puncture will be performed and CSF samples (20-30 mL) stored in the NCTC Biorepository until shipment to the CLIA-certified laboratory.~Both CSF and blood samples will be analyzed for t-tau, p-tau, and Aβ42 and stored for future testing,

Intervention type: DIAGNOSTIC_TEST
Intervention: Applanation Tonometry
Description: Hearth health is evaluated through testing of arterial stiffness and pulse wave reflections using a high fidelity applanation tonometer.

Intervention type: DIAGNOSTIC_TEST
Intervention: Applanation Tonometry
Description: Hearth health is evaluated through testing of arterial stiffness and pulse wave reflections using a high fidelity applanation tonometer.

Intervention type: DIAGNOSTIC_TEST
Intervention: PET brain imaging
Description: PET imaging of the brain using tau and amyloid ligands.

Intervention type: DIAGNOSTIC_TEST
Intervention: PET brain imaging
Description: PET imaging of the brain using tau and amyloid ligands.

Intervention type: DRUG
Intervention: [C-11]6-OH-BTA-1
Description: PET imaging of the brain using an amyloid ligand.

Intervention type: DRUG
Intervention: [C-11]6-OH-BTA-1
Description: PET imaging of the brain using an amyloid ligand.

Intervention type: DRUG
Intervention: [F-18]AV-1451
Description: PET imaging of the brain using a tau ligand.

Intervention type: DRUG
Intervention: [F-18]AV-1451
Description: PET imaging of the brain using a tau ligand.