Study: NCT03655392

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Individualized educational program
Description: IG patients were submitted to three 30-minutes intervention of a individualized shortterm educational program delivered by a nurse, were given explanations about general aspects of the disease, prevention methods and about the importance and correct use of inhaled corticosteroids, with an educational video showing the use of the device

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Induced sputum collection
Description: All participants performed induced sputum collection

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Induced sputum collection
Description: All participants performed induced sputum collection

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Spirometry
Description: All participants performed spirometry test using a Koko spirometer. Pulmonary function was assessed by spirometry prebronchodilator, after withholding short-acting beta-agonists for ≥ 6 hours and long-acting beta-agonist for ≥ 24hours. Forced expiratory volume in one second (FEV1) % predicted was used as a proxy variable for overall lung function.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Spirometry
Description: All participants performed spirometry test using a Koko spirometer. Pulmonary function was assessed by spirometry prebronchodilator, after withholding short-acting beta-agonists for ≥ 6 hours and long-acting beta-agonist for ≥ 24hours. Forced expiratory volume in one second (FEV1) % predicted was used as a proxy variable for overall lung function.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Nitric oxide measure
Description: All participants performed nitric oxide measure in three Mylar bags and measure was performed in a NOA280 Sievers equipment. For collection the patients blew in the balloons through a sterile nozzle in the equipment collector without prejudice or damage to the patient.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Nitric oxide measure
Description: All participants performed nitric oxide measure in three Mylar bags and measure was performed in a NOA280 Sievers equipment. For collection the patients blew in the balloons through a sterile nozzle in the equipment collector without prejudice or damage to the patient.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaires ACT, ACQ, AQLQ, BDI
Description: All participants answered standardized questionnaires about asthma symptoms and depression: Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ), Beck Depression Inventory (BDI)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Questionnaires ACT, ACQ, AQLQ, BDI
Description: All participants answered standardized questionnaires about asthma symptoms and depression: Asthma Control Test (ACT), Asthma Control Questionnaire (ACQ), Asthma Quality Life Questionnaire (AQLQ), Beck Depression Inventory (BDI)

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Symptoms Diary
Description: All participants were instructed to note in the morning and evening before the use of routine inhaled corticosteroids, asthma symptoms (coughing, wheezing, shortness of breath, use of emergency inhaled corticosteroids) and three measures of peak expiratory flow (individual, provided to patients) and to return this completed diary at each study visit

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Symptoms Diary
Description: All participants were instructed to note in the morning and evening before the use of routine inhaled corticosteroids, asthma symptoms (coughing, wheezing, shortness of breath, use of emergency inhaled corticosteroids) and three measures of peak expiratory flow (individual, provided to patients) and to return this completed diary at each study visit

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Peak flow measure
Description: All participants registered three peak flow measures in the symptoms diary by morning and night before the use of routine inhaled corticosteroids. Peak flow was measured by the electronic peak flow meter (Mini-Wright).

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Peak flow measure
Description: All participants registered three peak flow measures in the symptoms diary by morning and night before the use of routine inhaled corticosteroids. Peak flow was measured by the electronic peak flow meter (Mini-Wright).

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Exhaled breath condensate air measurement
Description: Exhaled breath condensate was collect during 15 to 20 minutes in a Turbo DECCS equipment (Medivac SRL, Italy) in a sterile buccal of the own apparatus with the aid of a nasal clip with the participant breathing normally without any effort or damage.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Exhaled breath condensate air measurement
Description: Exhaled breath condensate was collect during 15 to 20 minutes in a Turbo DECCS equipment (Medivac SRL, Italy) in a sterile buccal of the own apparatus with the aid of a nasal clip with the participant breathing normally without any effort or damage.