Study: NCT01578889

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: HIV-MAG vaccine
Description: Participants assigned to receive the HIV-MAG vaccine will receive 3 mg of the vaccine with bupivacaine, alone or admixed with one of three doses of the IL-12 pDNA adjuvant.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: HIV-MAG vaccine
Description: Participants assigned to receive the HIV-MAG vaccine will receive 3 mg of the vaccine with bupivacaine, alone or admixed with one of three doses of the IL-12 pDNA adjuvant.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IL-12 pDNA adjuvant
Description: Participants assigned to receive the IL-12 plasmid (IL-12 pDNA) adjuvant will receive one of three doses (total of 250 mcg, 1000 mcg, or 1500 mcg) of the adjuvant admixed with the HIV-MAG vaccine.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IL-12 pDNA adjuvant
Description: Participants assigned to receive the IL-12 plasmid (IL-12 pDNA) adjuvant will receive one of three doses (total of 250 mcg, 1000 mcg, or 1500 mcg) of the adjuvant admixed with the HIV-MAG vaccine.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: IL-12 pDNA adjuvant
Description: Participants assigned to receive the IL-12 plasmid (IL-12 pDNA) adjuvant will receive one of three doses (total of 250 mcg, 1000 mcg, or 1500 mcg) of the adjuvant admixed with the HIV-MAG vaccine.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VSV HIV gag vaccine
Description: Participants assigned to receive the VSV HIV gag vaccine will receive a total dose of 1x10\^8 plaque-forming units (PFUs) administered as 5x10\^7 PFU in 1 mL by IM injection in both the left and right deltoids at Month 6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VSV HIV gag vaccine
Description: Participants assigned to receive the VSV HIV gag vaccine will receive a total dose of 1x10\^8 plaque-forming units (PFUs) administered as 5x10\^7 PFU in 1 mL by IM injection in both the left and right deltoids at Month 6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VSV HIV gag vaccine
Description: Participants assigned to receive the VSV HIV gag vaccine will receive a total dose of 1x10\^8 plaque-forming units (PFUs) administered as 5x10\^7 PFU in 1 mL by IM injection in both the left and right deltoids at Month 6.

Intervention type: BIOLOGICAL
Group type: EXPERIMENTAL
Intervention: VSV HIV gag vaccine
Description: Participants assigned to receive the VSV HIV gag vaccine will receive a total dose of 1x10\^8 plaque-forming units (PFUs) administered as 5x10\^7 PFU in 1 mL by IM injection in both the left and right deltoids at Month 6.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will consist of sodium chloride for injection, USP 0.9%.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will consist of sodium chloride for injection, USP 0.9%.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will consist of sodium chloride for injection, USP 0.9%.

Intervention type: BIOLOGICAL
Group type: PLACEBO_COMPARATOR
Intervention: Placebo
Description: Placebo will consist of sodium chloride for injection, USP 0.9%.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.

Intervention type: DEVICE
Group type: EXPERIMENTAL
Intervention: Ichor Medical Systems TriGrid™ Delivery System (TDS) electroporation (EP) device
Description: The HIV-MAG vaccine, IL-12 pDNA adjuvant, and placebos for IL-12 pDNA adjuvant/HIV-MAG vaccines will be delivered IM into the deltoid by the Ichor Medical Systems TDS EP device.