Study: NCT03973229

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Estradiol patch
Description: Estradiol (E2) patches at a dose of 100ug will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Placebo patch
Description: Placebo patch identical to the estradiol patch will be applied 24-48 hours before the MRI scan is performed.