Study: NCT03553238

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Chidamide
Description: Chidamide will be administrated at a dose of 10mg/day in PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexamethasone
Description: Dexamethasone will be added in Pre-phase Regimen, Induction-Regimen, Consolidation-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: vincristine
Description: Vincristine will be added to Induction-Regimen, Consolidation-Module and Maintenance-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: CTX will be added to Induction-Regimen, Consolidation-Module and Maintenance-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Idarubicin
Description: IDA will be added to Induction-Regimen and Consolidation-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pegaspargase
Description: PEG-ASP will be added to Induction-Regimen and Consolidation-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Adriamycin
Description: Adriamycin will be added to Consolidation-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Methotrexate
Description: Methotrexate will be added to consolidation module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: 6-Mercaptopurine
Description: Mercaptopurine will be added to Consolidation-Module and Maintenance-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etoposide
Description: VP-16 will be added to Consolidation-Module of PDT-ETP-ALL protocol.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cytarabine
Description: AraC will be added to Consolidation-Module of PDT-ETP-ALL protocol.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone marrow aspiration
Description: Bone marrow aspiration and additional tests will be performed in all module of PDT-ETP-ALL protocol.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intrathecal injection
Description: Intrathecal injection chemotherapy will be performed in PDT-ETP-ALL protocol.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Radiation therapy
Description: Radiation therapy will be performed for mediastinum and/or central nervous system leukemia in PDT-ETP-ALL protocol.

Intervention type: GENETIC
Group type: EXPERIMENTAL
Intervention: NGS
Description: Next-Generation-Sequencing (NGS) will be performed in PDT-ETP-ALL protocol.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: allogeneic hematopoietic stem cell transplantation
Description: Allo-HSCT will be performed for patients with available donor in PDT-ETP-ALL protocol.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Flow-MRD
Description: Flow-MRD will be added to PDT-ETP-ALL for bone marrow and cerebrospinal fluid samples.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: FISH
Description: FISH will be performed in PDT-ETP-ALL for bone marrow samples.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Flow immunophenotyping
Description: Flow immunophenotyping will be performed in PDT-ETP-ALL protocol.

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Karyotyping
Description: Karyotyping will be performed in PDT-ETP-ALL protocol.