Study: NCT01033552

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamide 50 mg/kg/day IV over 2 hours x 1 day, total dose 50 mg/kg will be administered on Day -6.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamide 50 mg/kg/day IV over 2 hours x 1 day, total dose 50 mg/kg will be administered on Day -6.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamide 50 mg/kg/day IV over 2 hours x 1 day, total dose 50 mg/kg will be administered on Day -6.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cyclophosphamide
Description: Cyclophosphamide 50 mg/kg/day IV over 2 hours x 1 day, total dose 50 mg/kg will be administered on Day -6.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: 40 mg/m\^2/day intravenously on Days -6, -5, -4, -3 and -2.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: 40 mg/m\^2/day intravenously on Days -6, -5, -4, -3 and -2.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: 40 mg/m\^2/day intravenously on Days -6, -5, -4, -3 and -2.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Fludarabine
Description: 40 mg/m\^2/day intravenously on Days -6, -5, -4, -3 and -2.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anti-thymocyte globulin
Description: 30 mg/kg on Days -4, -3 and -2.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Anti-thymocyte globulin
Description: 30 mg/kg on Days -4, -3 and -2.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Myeloablative Busulfan
Description: Targeting AUC 1000 umol/min

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Myeloablative Busulfan
Description: Targeting AUC 1000 umol/min

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Mesenchymal stem cell transplantation
Description: infused via intravenous drip on Day 0

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Mesenchymal stem cell transplantation
Description: infused via intravenous drip on Day 0

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Mesenchymal stem cell transplantation
Description: infused via intravenous drip on Day 0

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Mesenchymal stem cell transplantation
Description: infused via intravenous drip on Day 0

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Total body irradiation
Description: 300 cGY on Day -1 administered in a single fraction at a dose rate of 10-19 cGy/minute prescribed to the midplane of the patient at the level of the umbilicus.

Intervention type: RADIATION
Group type: EXPERIMENTAL
Intervention: Total body irradiation
Description: 300 cGY on Day -1 administered in a single fraction at a dose rate of 10-19 cGy/minute prescribed to the midplane of the patient at the level of the umbilicus.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone marrow or umbilical cord blood (UCG) stem cell transplantation
Description: Bone marrow or UCB products will be infused as soon as the product arrives and within 30 minutes. The product is infused via IV drip.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone marrow or umbilical cord blood (UCG) stem cell transplantation
Description: Bone marrow or UCB products will be infused as soon as the product arrives and within 30 minutes. The product is infused via IV drip.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone marrow or umbilical cord blood (UCG) stem cell transplantation
Description: Bone marrow or UCB products will be infused as soon as the product arrives and within 30 minutes. The product is infused via IV drip.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Bone marrow or umbilical cord blood (UCG) stem cell transplantation
Description: Bone marrow or UCB products will be infused as soon as the product arrives and within 30 minutes. The product is infused via IV drip.