Study: NCT04219358

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vehicle Gel Base
Description: Apply 0.5ml of gel stored in a 1ml syringe over the lip 3 times a week (Mondays, Wednesdays and Fridays) at night for a period of 4 weeks.~Gel components: medium molecular weight chitosan, lactic acid 85% and water.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Imiquimod 5% gel
Description: Apply 0.5ml of gel stored in a 1ml syringe over the lip 3 times a week (Mondays, Wednesdays and Fridays) at night for a period of 4 weeks.~Gel components: medium molecular weight chitosan, lactic acid 85% and free form imiquimod 5%.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Imiquimod 0,05% gel
Description: Apply 0.5ml of gel stored in a 1ml syringe over the lip 3 times a week (Mondays, Wednesdays and Fridays) at night for a period of 4 weeks.~Gel components: medium molecular weight chitosan, lactic acid 85% and imiquimod 0.05% free form.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Imiquimod nanoencapsulated 0,05% gel
Description: Apply 0.5ml of gel stored in a 1ml syringe over the lip 3 times a week (Mondays, Wednesdays and Fridays) at night for a period of 4 weeks.~Gel components: medium molecular weight chitosan, lactic acid 85% and imiquomod in a nanoencapsulated suspension at concentration of 0,05%

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lip sunscreen 30 Sun Protector Factor (SPF)
Description: Apply sunscreen on the lip 30 minutes every day before sun exposure. Protects against both UVA (ultraviolet A) and UVB (ultraviolet B rays).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lip sunscreen 30 Sun Protector Factor (SPF)
Description: Apply sunscreen on the lip 30 minutes every day before sun exposure. Protects against both UVA (ultraviolet A) and UVB (ultraviolet B rays).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Lip sunscreen 30 Sun Protector Factor (SPF)
Description: Apply sunscreen on the lip 30 minutes every day before sun exposure. Protects against both UVA (ultraviolet A) and UVB (ultraviolet B rays).

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Lip sunscreen 30 Sun Protector Factor (SPF)
Description: Apply sunscreen on the lip 30 minutes every day before sun exposure. Protects against both UVA (ultraviolet A) and UVB (ultraviolet B rays).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexpanthenol
Description: Apply dexpanthenol on the lip, two (2) times a day, once in the morning and once in the afternoon.~Reduces transepidermic water loss and maintaining the natural smoothness and elasticity of the skin. It accelerates the cell renewal, rebuilds damaged tissues and promote the normal keratinisation of the skin and hair.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexpanthenol
Description: Apply dexpanthenol on the lip, two (2) times a day, once in the morning and once in the afternoon.~Reduces transepidermic water loss and maintaining the natural smoothness and elasticity of the skin. It accelerates the cell renewal, rebuilds damaged tissues and promote the normal keratinisation of the skin and hair.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dexpanthenol
Description: Apply dexpanthenol on the lip, two (2) times a day, once in the morning and once in the afternoon.~Reduces transepidermic water loss and maintaining the natural smoothness and elasticity of the skin. It accelerates the cell renewal, rebuilds damaged tissues and promote the normal keratinisation of the skin and hair.

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dexpanthenol
Description: Apply dexpanthenol on the lip, two (2) times a day, once in the morning and once in the afternoon.~Reduces transepidermic water loss and maintaining the natural smoothness and elasticity of the skin. It accelerates the cell renewal, rebuilds damaged tissues and promote the normal keratinisation of the skin and hair.