Study: NCT01019343

Intervention type: PROCEDURE
Group type: PLACEBO_COMPARATOR
Intervention: Transcranial Direct Current Stimulation (tDCS)
Description: Transcranial direct current stimulation involves the application of weak direct currents, delivered between two surface electrodes, placed over the scalp.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Transcranial Direct Current Stimulation (tDCS)
Description: Transcranial direct current stimulation involves the application of weak direct currents, delivered between two surface electrodes, placed over the scalp.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Eye-tracking Device
Description: The purpose of this device is to assess eye movement. Participants may sit down in front of a computer screen or a real-world environment, stand on a treadmill, or lie down in an MRI scanner. Small infrared cameras attached to the cap or glasses will be positioned in front of their eyes. Eye tracking might be performed alone, or in conjunction with EEG, EMG, fMRI or treadmill. The eye- tracking device is FDA approved and commercially available.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Eye-tracking Device
Description: The purpose of this device is to assess eye movement. Participants may sit down in front of a computer screen or a real-world environment, stand on a treadmill, or lie down in an MRI scanner. Small infrared cameras attached to the cap or glasses will be positioned in front of their eyes. Eye tracking might be performed alone, or in conjunction with EEG, EMG, fMRI or treadmill. The eye- tracking device is FDA approved and commercially available.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: Pulsed vibrator
Description: This device would be used in experiments to see if gait can be improved and, if so, what parameters of stimulation are optimal.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: Pulsed vibrator
Description: This device would be used in experiments to see if gait can be improved and, if so, what parameters of stimulation are optimal.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Gait Trainer Treadmill (GTT)
Description: The Gait Trainer is a specialized rehabilitation treadmill, which operates in both the forward and backwards mode allowing subjects to both train and undergo performance tasks in a relatively safe and expedient manner. The GTT is equipped with a mounted deck with built in sensors which monitors and records subjects gait speed, step length, right to left time distribution, and symmetry in real time in both forward and reverse modes.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Gait Trainer Treadmill (GTT)
Description: The Gait Trainer is a specialized rehabilitation treadmill, which operates in both the forward and backwards mode allowing subjects to both train and undergo performance tasks in a relatively safe and expedient manner. The GTT is equipped with a mounted deck with built in sensors which monitors and records subjects gait speed, step length, right to left time distribution, and symmetry in real time in both forward and reverse modes.

Intervention type: OTHER
Group type: PLACEBO_COMPARATOR
Intervention: Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCA
Description: Scales of motor function, cognitive function and psychiatric function are valuable supplements to clinical assessments of patients, giving quantitative information concerning these different aspects of brain function. Selected scales would be used only when potentially useful in a sub-study where such quantitative information would be correlated with a physiological or imaging result.

Intervention type: OTHER
Group type: ACTIVE_COMPARATOR
Intervention: Standard psychiatric scales SCID-I, YBOCS and SCI-OBS-lifetime and cognitive scales MMSE and MOCA
Description: Scales of motor function, cognitive function and psychiatric function are valuable supplements to clinical assessments of patients, giving quantitative information concerning these different aspects of brain function. Selected scales would be used only when potentially useful in a sub-study where such quantitative information would be correlated with a physiological or imaging result.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: iMobility
Description: This test uses the iMobility system. iMobility Device is a small device designed to measure movement through sensors (test monitors) worn by a patient via Velcro straps around an ankle or wrist or worn as a pendant around the neck to lie over the sternum. The device is a nonsignificant risk device.The iMobility Device has been used before, in the same format with a similar paradigm, in previous NIH studies.

Intervention type: DEVICE
Group type: ACTIVE_COMPARATOR
Intervention: iMobility
Description: This test uses the iMobility system. iMobility Device is a small device designed to measure movement through sensors (test monitors) worn by a patient via Velcro straps around an ankle or wrist or worn as a pendant around the neck to lie over the sternum. The device is a nonsignificant risk device.The iMobility Device has been used before, in the same format with a similar paradigm, in previous NIH studies.

Intervention type: DEVICE
Group type: PLACEBO_COMPARATOR
Intervention: QMAT
Description: The purpose of this study is to assess the ability of the QMAT (quantitative motor assessment tool) to assess slowness of movement associated with Parkinson Disease. The QMAT device is FDA approved and has been used before, in the same format with a similar paradigm, in previous NIH studies.