Study: NCT05358912

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Vasopressor Agent
Description: Patients will receive vasopressor agents according to Surviving Sepsis Campaign Guidelines 2021

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vasopressor Agent
Description: Patients will receive vasopressor agents according to Surviving Sepsis Campaign Guidelines 2021

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Vasopressor Agent
Description: Patients will receive vasopressor agents according to Surviving Sepsis Campaign Guidelines 2021

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Crystalloid Solutions
Description: Patients will receive crystalloid solutions according to Surviving Sepsis Campaign Guidelines 2021

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Crystalloid Solutions
Description: Patients will receive crystalloid solutions according to Surviving Sepsis Campaign Guidelines 2021

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Crystalloid Solutions
Description: Patients will receive crystalloid solutions according to Surviving Sepsis Campaign Guidelines 2021

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Invasive Blood Pressure Monitoring
Description: Invasive blood pressure monitoring will be performed through an intra-arterial cannula placed in the radial artery. Philips Intellivue mx 500 monitors will be used for bedside monitoring.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Invasive Blood Pressure Monitoring
Description: Invasive blood pressure monitoring will be performed through an intra-arterial cannula placed in the radial artery. Philips Intellivue mx 500 monitors will be used for bedside monitoring.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Invasive Blood Pressure Monitoring
Description: Invasive blood pressure monitoring will be performed through an intra-arterial cannula placed in the radial artery. Philips Intellivue mx 500 monitors will be used for bedside monitoring.

Intervention type: PROCEDURE
Group type: EXPERIMENTAL
Intervention: Intra-Abdominal Pressure Monitoring
Description: IAP will be measured indirectly by monitoring the pressure in the bladder.~Bladder pressure will be measured through an indwelling Foley catheter every twelve hours. Twenty-five mL of sterile normal saline will be injected in each measurement and readings will be recorded with a pressure transducer.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Intra-Abdominal Pressure Monitoring
Description: IAP will be measured indirectly by monitoring the pressure in the bladder.~Bladder pressure will be measured through an indwelling Foley catheter every twelve hours. Twenty-five mL of sterile normal saline will be injected in each measurement and readings will be recorded with a pressure transducer.

Intervention type: PROCEDURE
Group type: ACTIVE_COMPARATOR
Intervention: Intra-Abdominal Pressure Monitoring
Description: IAP will be measured indirectly by monitoring the pressure in the bladder.~Bladder pressure will be measured through an indwelling Foley catheter every twelve hours. Twenty-five mL of sterile normal saline will be injected in each measurement and readings will be recorded with a pressure transducer.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Abdominal Perfusion Pressure
Description: APP will be calculated with the following formula: (Mean arterial pressure) - (Intra-abdominal Pressure)