Study: NCT01794689

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine
Description: 0.08mg/kg will be administered to participants randomly assigned to receive the drug via IV bolus during each quantitative sensory testing session (after one night of uninterrupted sleep and after 2 nights of forced awakenings).

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Morphine
Description: 0.08mg/kg will be administered to participants randomly assigned to receive the drug via IV bolus during each quantitative sensory testing session (after one night of uninterrupted sleep and after 2 nights of forced awakenings).

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline Placebo
Description: Saline Placebo will administered to participants randomly assigned to receive the placebo via IV bolus during each quantitative sensory testing session (after one night of uninterrupted sleep and after 2 nights of forced awakenings).

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Saline Placebo
Description: Saline Placebo will administered to participants randomly assigned to receive the placebo via IV bolus during each quantitative sensory testing session (after one night of uninterrupted sleep and after 2 nights of forced awakenings).

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Forced Awakenings
Description: Participants will be awakened each hour during an 8 hour sleep opportunity period. One of the awakenings is for 60 minutes and randomly determined. The other 7 awakenings are for 20 minutes each, and are randomly scheduled to occur in either the first second or third tertile of each hour. The maximum total sleep time a participant will receive is 280 minutes.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Forced Awakenings
Description: Participants will be awakened each hour during an 8 hour sleep opportunity period. One of the awakenings is for 60 minutes and randomly determined. The other 7 awakenings are for 20 minutes each, and are randomly scheduled to occur in either the first second or third tertile of each hour. The maximum total sleep time a participant will receive is 280 minutes.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Forced Awakenings
Description: Participants will be awakened each hour during an 8 hour sleep opportunity period. One of the awakenings is for 60 minutes and randomly determined. The other 7 awakenings are for 20 minutes each, and are randomly scheduled to occur in either the first second or third tertile of each hour. The maximum total sleep time a participant will receive is 280 minutes.

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Forced Awakenings
Description: Participants will be awakened each hour during an 8 hour sleep opportunity period. One of the awakenings is for 60 minutes and randomly determined. The other 7 awakenings are for 20 minutes each, and are randomly scheduled to occur in either the first second or third tertile of each hour. The maximum total sleep time a participant will receive is 280 minutes.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Uninterrupted Sleep
Description: Participants will receive an 8 hour period of undisturbed sleep

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: Uninterrupted Sleep
Description: Participants will receive an 8 hour period of undisturbed sleep

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Uninterrupted Sleep
Description: Participants will receive an 8 hour period of undisturbed sleep

Intervention type: BEHAVIORAL
Group type: PLACEBO_COMPARATOR
Intervention: Uninterrupted Sleep
Description: Participants will receive an 8 hour period of undisturbed sleep