Study: NCT02759887

Intervention type: PROCEDURE
Group type: OTHER
Intervention: biospecimen collection
Description: Blood: ApoE genotyping, comprehensive metabolic panel, RNA sequencing. Urine: beta-hCG (human corionic gonadotropin) testing.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: biospecimen collection
Description: Blood: ApoE genotyping, comprehensive metabolic panel, RNA sequencing. Urine: beta-hCG (human corionic gonadotropin) testing.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: biospecimen collection
Description: Blood: ApoE genotyping, comprehensive metabolic panel, RNA sequencing. Urine: beta-hCG (human corionic gonadotropin) testing.

Intervention type: OTHER
Group type: OTHER
Intervention: cognitive assessments
Description: Dementia Questionnaire for People with Learning Disabilities; Mini-Mental State Examination; Severe Impairment Battery; Vineland Adaptive Behavior Scale; Arizona Memory Assessment for Intellectual Disability; Kaufman Brief Intelligence Test; Nepsy Mazes; and, Timed Up and Go.

Intervention type: OTHER
Group type: OTHER
Intervention: cognitive assessments
Description: Dementia Questionnaire for People with Learning Disabilities; Mini-Mental State Examination; Severe Impairment Battery; Vineland Adaptive Behavior Scale; Arizona Memory Assessment for Intellectual Disability; Kaufman Brief Intelligence Test; Nepsy Mazes; and, Timed Up and Go.

Intervention type: OTHER
Group type: OTHER
Intervention: cognitive assessments
Description: Dementia Questionnaire for People with Learning Disabilities; Mini-Mental State Examination; Severe Impairment Battery; Vineland Adaptive Behavior Scale; Arizona Memory Assessment for Intellectual Disability; Kaufman Brief Intelligence Test; Nepsy Mazes; and, Timed Up and Go.

Intervention type: OTHER
Group type: OTHER
Intervention: caregiver questionnaire

Intervention type: OTHER
Group type: OTHER
Intervention: caregiver questionnaire

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Florbetapir F18 imaging
Description: Used in small doses to image brain amyloid-beta deposits in human beings. Radioactivity necessary to create the positron emission tomography (PET) images. Radiation exposure is slightly more than a person would receive from a routine clinical head computed tomography scan.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Florbetapir F18 imaging
Description: Used in small doses to image brain amyloid-beta deposits in human beings. Radioactivity necessary to create the positron emission tomography (PET) images. Radiation exposure is slightly more than a person would receive from a routine clinical head computed tomography scan.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Florbetapir F18 imaging
Description: Used in small doses to image brain amyloid-beta deposits in human beings. Radioactivity necessary to create the positron emission tomography (PET) images. Radiation exposure is slightly more than a person would receive from a routine clinical head computed tomography scan.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: MRI
Description: Magnetic resonance imaging of the head and brain.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: MRI
Description: Magnetic resonance imaging of the head and brain.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: MRI
Description: Magnetic resonance imaging of the head and brain.

Intervention type: PROCEDURE
Group type: OTHER
Intervention: Fludeoxyglucose F18 (FDG)
Description: Injected intravenously during a PET scan and is a marker for the tissue uptake of glucose; a radiopharmaceutical compound.