Study: NCT03345407

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Albuterol (Salbutamol) MDI or nebules
Description: Albuterol (Salbutamol) MDI or nebules will be provided to all subjects as a rescue medication.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Albuterol (Salbutamol) MDI or nebules
Description: Albuterol (Salbutamol) MDI or nebules will be provided to all subjects as a rescue medication.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Albuterol (Salbutamol) MDI or nebules
Description: Albuterol (Salbutamol) MDI or nebules will be provided to all subjects as a rescue medication.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Albuterol (Salbutamol) MDI or nebules
Description: Albuterol (Salbutamol) MDI or nebules will be provided to all subjects as a rescue medication.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Albuterol (Salbutamol) MDI or nebules
Description: Albuterol (Salbutamol) MDI or nebules will be provided to all subjects as a rescue medication.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard of care therapy
Description: SoC therapy for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according to the Investigator's/medically qualified designee's judgment or according to local country/institution practice.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard of care therapy
Description: SoC therapy for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according to the Investigator's/medically qualified designee's judgment or according to local country/institution practice.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard of care therapy
Description: SoC therapy for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according to the Investigator's/medically qualified designee's judgment or according to local country/institution practice.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard of care therapy
Description: SoC therapy for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according to the Investigator's/medically qualified designee's judgment or according to local country/institution practice.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Standard of care therapy
Description: SoC therapy for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according to the Investigator's/medically qualified designee's judgment or according to local country/institution practice.

Intervention type: DRUG
Group type: PLACEBO_COMPARATOR
Intervention: Standard of care therapy
Description: SoC therapy for the index exacerbation is defined as treatment with oral/systemic corticosteroid (prednisone 40 mg/day or equivalent) for 5 days and antibiotic for 7 days. Subjects will receive SoC as prescribed by the Investigator or medically qualified designee. The dose and/or duration of prednisone and/or the antibiotic can be modified according to the Investigator's/medically qualified designee's judgment or according to local country/institution practice.