Study: NCT03251482

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 0.3 mg/kg
Description: JNJ-64179375 0.3 milligram per kilogram (mg/kg) intravenous (IV) infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 0.6 mg/kg
Description: JNJ-64179375 0.6 mg/kg IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 1.2 mg/kg
Description: JNJ-64179375 1.2 mg/kg IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 (Dose to be Determined)
Description: JNJ-64179375 IV infusion (Dose to be determined) as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 (Dose to be Determined)
Description: JNJ-64179375 IV infusion (Dose to be determined) as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 (Dose to be Determined)
Description: JNJ-64179375 IV infusion (Dose to be determined) as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 A mg/kg
Description: JNJ-64179375 Dose A mg/kg IV as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 B mg/kg
Description: JNJ-64179375 Dose B mg/kg IV as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 C mg/kg
Description: JNJ-64179375 Dose C mg/kg IV as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: JNJ-64179375 D mg/kg
Description: JNJ-64179375 Dose D mg/kg IV as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo JNJ-64179375
Description: Matching JNJ-64179375 placebo (normal saline) administered as IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo JNJ-64179375
Description: Matching JNJ-64179375 placebo (normal saline) administered as IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo JNJ-64179375
Description: Matching JNJ-64179375 placebo (normal saline) administered as IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo JNJ-64179375
Description: Matching JNJ-64179375 placebo (normal saline) administered as IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo JNJ-64179375
Description: Matching JNJ-64179375 placebo (normal saline) administered as IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo JNJ-64179375
Description: Matching JNJ-64179375 placebo (normal saline) administered as IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Placebo JNJ-64179375
Description: Matching JNJ-64179375 placebo (normal saline) administered as IV infusion as a single dose on Day 1.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban placebo
Description: Matching apixaban placebo administered orally twice a day for 10 to 14 days.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Apixaban 2.5 mg
Description: Apixaban 2.5 mg administered orally twice a day for 10 to 14 days.