Study: NCT03539081

Intervention type: DIAGNOSTIC_TEST
Group type: EXPERIMENTAL
Intervention: Dual-energy X-ray absorptiometry Scan
Description: Body composition analysis will be obtained by DEXA scan.

Intervention type: DIAGNOSTIC_TEST
Group type: OTHER
Intervention: Dual-energy X-ray absorptiometry Scan
Description: Body composition analysis will be obtained by DEXA scan.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Laboratory Measurements
Description: The following labs will be obtained during the course of the study: pregnancy test (urine), glucose, insulin, catecholamine, and cholesterol (serum).

Intervention type: OTHER
Group type: OTHER
Intervention: Laboratory Measurements
Description: The following labs will be obtained during the course of the study: pregnancy test (urine), glucose, insulin, catecholamine, and cholesterol (serum).

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Blood Flow Measurement
Description: The blood flow to the arm or leg may also be measured by placing an ultrasonic probe on the skin over the femoral artery of the leg and the brachial artery of the arm.

Intervention type: OTHER
Group type: OTHER
Intervention: Blood Flow Measurement
Description: The blood flow to the arm or leg may also be measured by placing an ultrasonic probe on the skin over the femoral artery of the leg and the brachial artery of the arm.

Intervention type: OTHER
Group type: OTHER
Intervention: Continuous Blood Pressure
Description: Continuous Blood pressure cuff will worn for 2 days with spinal cord stimulator on and off (24 hour on and 24 hour off). Optional procedure.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Partial pressure of oxygen
Description: Transcutaneous recordings will be captured to measure the partial pressure of oxygen by placing monitors on the subject's chest and foot.

Intervention type: OTHER
Group type: OTHER
Intervention: Partial pressure of oxygen
Description: Transcutaneous recordings will be captured to measure the partial pressure of oxygen by placing monitors on the subject's chest and foot.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Microneurography
Description: The sympathetic nervous system activity to the subject's leg muscles will be measured by a tiny microelectrode placed in the peroneal nerve in the leg located just below the knee on the outer part of the leg. When the nerve is located 2 tiny sterile microelectrodes will be inserted through the skin.

Intervention type: OTHER
Group type: OTHER
Intervention: Microneurography
Description: The sympathetic nervous system activity to the subject's leg muscles will be measured by a tiny microelectrode placed in the peroneal nerve in the leg located just below the knee on the outer part of the leg. When the nerve is located 2 tiny sterile microelectrodes will be inserted through the skin.

Intervention type: OTHER
Group type: EXPERIMENTAL
Intervention: Anthropometric Measurements
Description: Height and weight will be obtained.

Intervention type: OTHER
Group type: OTHER
Intervention: Anthropometric Measurements
Description: Height and weight will be obtained.

Intervention type: BEHAVIORAL
Group type: EXPERIMENTAL
Intervention: John Hopkins Restless Legs Severity Scale
Description: Subjects will be administered questionnaires to evaluate RLS symptoms using John Hopkins Restless Legs Severity Scale.

Intervention type: BEHAVIORAL
Group type: OTHER
Intervention: Continuous Blood Pressure Diary
Description: Subjects participating in Continuous Blood Pressure monitoring will be administered continuous blood pressure monitoring compliance diary.