Study: NCT03311841

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Midazolam oral solution
Description: Midazolam hydrochloride 10 μg (1 mL of 10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Midazolam oral solution
Description: Midazolam hydrochloride 10 μg (1 mL of 10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Midazolam oral solution
Description: Midazolam hydrochloride 10 μg (1 mL of 10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Midazolam oral solution
Description: Midazolam hydrochloride 10 μg (1 mL of 10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Midazolam oral solution
Description: Midazolam hydrochloride 10 μg (1 mL of 10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dabigatran and pitavastatin oral solution
Description: 375/10 μg dabigatran etexilate and pitavastatin (1 mL of 375/10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Dabigatran and pitavastatin oral solution
Description: 375/10 μg dabigatran etexilate and pitavastatin (1 mL of 375/10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dabigatran and pitavastatin oral solution
Description: 375/10 μg dabigatran etexilate and pitavastatin (1 mL of 375/10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dabigatran and pitavastatin oral solution
Description: 375/10 μg dabigatran etexilate and pitavastatin (1 mL of 375/10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Dabigatran and pitavastatin oral solution
Description: 375/10 μg dabigatran etexilate and pitavastatin (1 mL of 375/10 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atorvastatin and rosuvastatin oral solution
Description: 100/50 μg atorvastatin and rosuvastatin (2 mL of 50/25 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Atorvastatin and rosuvastatin oral solution
Description: 100/50 μg atorvastatin and rosuvastatin (2 mL of 50/25 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atorvastatin and rosuvastatin oral solution
Description: 100/50 μg atorvastatin and rosuvastatin (2 mL of 50/25 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atorvastatin and rosuvastatin oral solution
Description: 100/50 μg atorvastatin and rosuvastatin (2 mL of 50/25 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Atorvastatin and rosuvastatin oral solution
Description: 100/50 μg atorvastatin and rosuvastatin (2 mL of 50/25 μg/mL oral solution), administered orally as part of a microdose cocktail

Intervention type: DRUG
Group type: ACTIVE_COMPARATOR
Intervention: Rifampin
Description: Rifampin 600 mg single dose (two 300 mg capsules) administered orally