Study: NCT03944772

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Osimertinib
Description: Osimertinib given orally at 80 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Savolitinib
Description: Savolitinib will be given orally at 300 mg or 600mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Gefitinib
Description: Gefitinib given orally at 250 mg once daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Necitumumab
Description: Necitumumab given IV at 800 mg on Day 1 and Day 8 of every 3-week cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab
Description: Durvalumab given IV at 1500 mg on Day 1 of every cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Durvalumab
Description: Durvalumab given IV at 1500 mg on Day 1 of every cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Carboplatin given IV on Day 1 of every 21-day cycle for up to 6 cycles

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Carboplatin given IV on Day 1 of every 21-day cycle for up to 6 cycles

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Carboplatin
Description: Carboplatin given IV on Day 1 of every 21-day cycle for up to 6 cycles

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pemetrexed
Description: Pemetrexed given IV at 500 mg/m2 body BSA on Day 1 of every cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Pemetrexed
Description: Pemetrexed given IV at 500 mg/m2 body BSA on Day 1 of every cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Alectinib
Description: Alectinib given orally at 600mg twice daily and for Japanese patients at 300mg twice daily.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selpercatinib
Description: Selpercatinib given orally at 160mg twice daily

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Selumetinib
Description: Selumetinib given orally at 75 mg twice daily for 4 days, followed by 3 days off treatment

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Etoposide
Description: Etoposide 80-100 mg/m2 given IV on day 1, 2 and 3 of every 21-day cycle for up to 4 cycles.

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Cisplatin 75-80 mg/m2 given IV on days 1 of each cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Cisplatin
Description: Cisplatin 75-80 mg/m2 given IV on days 1 of each cycle

Intervention type: DRUG
Group type: EXPERIMENTAL
Intervention: Datopotamab deruxtecan
Description: Datopotamab deruxtecan given IV at 4 or 6 mg/kg on Day 1 of every 3-week cycle.