TrialPanorama/TrialPanorama-database huggingface dataset:
Study 33371139 — Surrogate Endpoint (SUR): Blood pressure
Study 36410472 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 35046055 — Predictive Biomarker (PRD): CXCR3 mRNA
Genes: CXCR3; GPR9
Study 35046055 — Predictive Biomarker (PRD): TLR3 mRNA
Genes: TLR3
Study 34546139 — Surrogate Endpoint (SUR): Blood pressure
Study 34546139 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 36504629 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 36504629 — Safety Biomarker (SAF): BDNF
Study 32488856 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 35997144 — Surrogate Endpoint (SUR): Blood pressure
Study 37436828 — Surrogate Endpoint (SUR): Forced vital capacity
Study 32299251 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 32820573 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 33338947 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 32504574 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HLA-B
Genes: AS
Study 34085466 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 34085466 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34085466 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 33955809 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 33955809 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 33955809 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 33637020 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 32140811 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 32140811 — Surrogate Endpoint (SUR): Pathological complete response
Study 32140811 — Predictive Biomarker (PRD): Hormone receptor
Study 36339436 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 32447296 — Safety Biomarker (SAF): PDCD1
Genes: CD279; PD1; hSLE1; PD-1
Study 34670666 — Predictive Biomarker (PRD): ASL mRNA
Genes: ASL
Study 32925910 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 35683447 — Predictive Biomarker (PRD): RUNX2 mRNA
Genes: RUNX2; AML3; CBFA1; OSF2; PEBP2A
Study 35683447 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Osteopontin
Genes: SPP1; BNSP; OPN; PSEC0156
Study 32575868 — Predictive Biomarker (PRD): FN1 mRNA
Genes: FN1; FN
Study 34110712 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 32458074 — Surrogate Endpoint (SUR): Probing pocket depth
Study 35572910 — Surrogate Endpoint (SUR): Forced vital capacity
Study 34280820 — Safety Biomarker (SAF): BDNF
Study 34280820 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 35488826 — Predictive Biomarker (PRD): REL mRNA
Genes: REL
Study 33653365 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 33653365 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 33653365 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 33653365 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 33653365 — Safety Biomarker (SAF): IL-6 and IL-10
Study 33674897 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 33246500 — Surrogate Endpoint (SUR): Blood pressure
Study 32016386 — Surrogate Endpoint (SUR): Bone mineral density
Study 33408073 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 34550860 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 34550860 — Predictive Biomarker (PRD): CDKN2A mRNA
Genes: CDKN2A; CDKN2; MTS1
Study 34550860 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 35737565 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 36066323 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 36454969 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 34825617 — Surrogate Endpoint (SUR): Blood pressure
Study 36153153 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 36153153 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 33502416 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 33502416 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 33502416 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 35171260 — Predictive Biomarker (PRD): HGS mRNA
Genes: HGS; HRS
Study 35285487 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 32841271 — Surrogate Endpoint (SUR): Blood pressure
Study 35193718 — Surrogate Endpoint (SUR): Blood pressure
Study 32154613 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 32154613 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32154613 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 32154613 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 32154613 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 32154613 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 33941564 — Monitoring Biomarker (MOI): Procalcitonin
Study 34477880 — Predictive Biomarker (PRD): TERT mRNA
Genes: TERT; EST2; TCS1; TRT
Study 34477880 — Predictive Biomarker (PRD): STN1 mRNA
Genes: STN1; OBFC1
Study 34477880 — Predictive Biomarker (PRD): STMN3 mRNA
Genes: STMN3; SCLIP
Study 34477880 — Predictive Biomarker (PRD): RTEL1 mRNA
Genes: RTEL1; C20orf41; KIAA1088; NHL
Study 34477880 — Predictive Biomarker (PRD): PARP1 mRNA
Genes: PARP1; ADPRT; PPOL
Study 34477880 — Predictive Biomarker (PRD): PRRC2A mRNA
Genes: PRRC2A; BAT2; G2
Study 34343632 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 34343632 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 32160205 — Surrogate Endpoint (SUR): Blood pressure
Study 33517032 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 35679810 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 35679810 — Safety Biomarker (SAF): BDNF
Study 32573729 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 32191943 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 36317082 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 33569574 — Surrogate Endpoint (SUR): Blood pressure
Study 34837524 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 35222072 — Surrogate Endpoint (SUR): Forced vital capacity
Study 34080237 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 34080237 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 33601293 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 35436644 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 33586201 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 34869163 — Surrogate Endpoint (SUR): Blood pressure
Study 35218673 — Predictive Biomarker (PRD): NR4A3 mRNA
Genes: NR4A3; CHN; CSMF; MINOR; NOR1; TEC
Study 34965609 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 32763585 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 33392946 — Predictive Biomarker (PRD): PPT1 mRNA
Genes: PPT1; CLN1; PPT
Study 36385018 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 36539602 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 34137530 — Surrogate Endpoint (SUR): Serum creatinine
Study 36426200 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 33524311 — Predictive Biomarker (PRD): ACE2 mRNA
Genes: ACE2; UNQ868/PRO1885
Study 33524311 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 616505842 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 34050681 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 34817270 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 32729273 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 34334297 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 35729675 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 35714273 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 35431966 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 35672178 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 35672178 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 34601838 — Predictive Biomarker (PRD): SDC1 mRNA
Genes: SDC1; SDC
Study 34601838 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 34601838 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 33427765 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 33534427 — Surrogate Endpoint (SUR): Blood pressure
Study 35874588 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 34617803 — Safety Biomarker (SAF): Interleukin 1
Study 33251643 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 32368972 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 32368972 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 32368972 — Safety Biomarker (SAF): Thiopurine S-methyltransferase
Genes: TPMT
Study 32809843 — Predictive Biomarker (PRD): TLR9
Genes: CD289
Study 32809843 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 34461742 — Surrogate Endpoint (SUR): Blood pressure
Study 36281666 — Predictive Biomarker (PRD): MCIDAS mRNA
Genes: MCIDAS; IDAS; MCI; MCIN
Study 33028548 — Predictive Biomarker (PRD): LSS mRNA
Genes: LSS; OSC
Study 35191215 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 32243432 — Predictive Biomarker (PRD): NR3C1 mRNA
Genes: NR3C1; GRL
Study 32243432 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 35787482 — Surrogate Endpoint (SUR): Bone mineral density
Study 36049698 — Predictive Biomarker (PRD): MCC mRNA
Genes: MCC
Study 34225789 — Predictive Biomarker (PRD): TMPRSS2 mRNA
Genes: TMPRSS2; PRSS10
Study 34225789 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 33888356 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 35166429 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 35139097 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 33726718 — Safety Biomarker (SAF): Hyaluronic acid
Study 35276764 — Predictive Biomarker (PRD): ADCY10 mRNA
Genes: ADCY10; SAC
Study 35276764 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 35276764 — Surrogate Endpoint (SUR): Blood pressure
Study 34162365 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 34162365 — Safety Biomarker (SAF): Hyaluronic acid
Study 32331937 — Predictive Biomarker (PRD): GFAP mRNA
Genes: GFAP
Study 32331937 — Predictive Biomarker (PRD): S100B mRNA
Genes: S100B
Study 32718702 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 32150489 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 33040018 — Predictive Biomarker (PRD): TMPRSS13 mRNA
Genes: TMPRSS13; MSP; TMPRSS11
Study 34915839 — Surrogate Endpoint (SUR): Blood pressure
Study 35170228 — Predictive Biomarker (PRD): MAP2K1 mRNA
Genes: MAP2K1; MEK1; PRKMK1
Study 32051080 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32051080 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 32051080 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 32540793 — Predictive Biomarker (PRD): PLXNA2 mRNA
Genes: PLXNA2; KIAA0463; OCT; PLXN2; UNQ209/PRO235
Study 32160968 — Surrogate Endpoint (SUR): Blood pressure
Study 34379607 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32031088 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 34163159 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34163159 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 35144924 — Surrogate Endpoint (SUR): Complete renal response
Study 32705833 — Predictive Biomarker (PRD): PCSK5 mRNA
Genes: PCSK5; PC5; PC6
Study 35687107 — Surrogate Endpoint (SUR): Serum potassium
Study 36323718 — Predictive Biomarker (PRD): EDA mRNA
Genes: EDA; ED1; EDA2
Study 32275367 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 32275367 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 32275367 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 32275367 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 33245796 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 35941548 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 35513022 — Predictive Biomarker (PRD): GLS mRNA
Genes: GLS; GLS1; KIAA0838
Study 33863842 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34799440 — Predictive Biomarker (PRD): Zinc finger protein GLI1
Genes: GLI1; GLI
Study 34799440 — Surrogate Endpoint (SUR): Forced vital capacity
Study 33653634 — Predictive Biomarker (PRD): Glutamate carboxypeptidase II
Genes: FOLH1; FOLH; NAALAD1; PSM; PSMA; GIG27
Study 34719909 — Safety Biomarker (SAF): Hyaluronic acid
Study 35143022 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 35143022 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 32399253 — Predictive Biomarker (PRD): SRI mRNA
Genes: SRI
Study 34039574 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 34039574 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 33160382 — Surrogate Endpoint (SUR): Blood pressure
Study 32085716 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 32918306 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 33122343 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 33122343 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 35064366 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34542190 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 34542190 — Predictive Biomarker (PRD): ESRRB mRNA
Genes: ESRRB; ERRB2; ESRL2; NR3B2
Study 34542190 — Predictive Biomarker (PRD): VASH1 mRNA
Genes: VASH1; KIAA1036; VASH
Study 35272949 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 35272949 — Surrogate Endpoint (SUR): Blood pressure
Study 33671217 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 33671217 — Predictive Biomarker (PRD): GLS2 mRNA
Genes: GLS2; GA
Study 33135182 — Surrogate Endpoint (SUR): Bone mineral density
Study 34292206 — Predictive Biomarker (PRD): PAG1 mRNA
Genes: PAG1; CBP; PAG
Study 34292206 — Predictive Biomarker (PRD): MCC mRNA
Genes: MCC
Study 34292206 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 33156099 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 35822425 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 35822425 — Surrogate Endpoint (SUR): Blood pressure
Study 33487503 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 33720637 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 33814546 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 33814546 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 34247604 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 34862248 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 34862248 — Safety Biomarker (SAF): PDCD1
Genes: CD279; PD1; hSLE1; PD-1
Study 35617098 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34318542 — Surrogate Endpoint (SUR): Blood pressure
Study 36134902 — Surrogate Endpoint (SUR): Bone mineral density
Study 34322673 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34903538 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 36150646 — Predictive Biomarker (PRD): HGD mRNA
Genes: HGD; HGO
Study 34164664 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 33517541 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 32465000 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 33933059 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 35156756 — Surrogate Endpoint (SUR): Blood pressure
Study 32697618 — Surrogate Endpoint (SUR): Blood pressure
Study 35486445 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32966919 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 36305511 — Predictive Biomarker (PRD): MME mRNA
Genes: MME; EPN
Study 34538072 — Predictive Biomarker (PRD): WEE1 mRNA
Genes: WEE1
Study 34538072 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 35439303 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 33234138 — Predictive Biomarker (PRD): ACE2 mRNA
Genes: ACE2; UNQ868/PRO1885
Study 33234138 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 33608319 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 33043883 — Predictive Biomarker (PRD): DMTN mRNA
Genes: DMTN; DMT; EPB49
Study 33023894 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 33023894 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 33023894 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34716213 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 35141484 — Predictive Biomarker (PRD): NMI mRNA
Genes: NMI
Study 35428697 — Predictive Biomarker (PRD): SRI mRNA
Genes: SRI
Study 33040356 — Predictive Biomarker (PRD): COL4A5 mRNA
Genes: COL4A5
Study 32782010 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 32986105 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 36423733 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 32790927 — Predictive Biomarker (PRD): PAG1 mRNA
Genes: PAG1; CBP; PAG
Study 33100044 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 34606378 — Predictive Biomarker (PRD): MYD88 mRNA
Genes: MYD88
Study 34606378 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 33411187 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 35395776 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 35395776 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 34610730 — Surrogate Endpoint (SUR): Blood pressure
Study 32240562 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MHC class I polypeptide-related sequence A
Genes: MICA; PERB11.1
Study 32240562 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 32240562 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 32240562 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 616871147 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 616871147 — Surrogate Endpoint (SUR): Blood pressure
Study 36197845 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 32331084 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC18A2 mRNA
Genes: SLC18A2; SVMT; VMAT2
Study 34848351 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 32187170 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 33944923 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 36236451 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 33397438 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 35381867 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 35129441 — Safety Biomarker (SAF): Reactive oxygen species