TrialPanorama/TrialPanorama-database huggingface dataset:
Study 33788480 — Predictive Biomarker (PRD): HOXA10 mRNA
Genes: HOXA10; HOX1H
Study 33455938 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 32517739 — Safety Biomarker (SAF): Hyaluronic acid
Study 35791797 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 34374027 — Predictive Biomarker (PRD): JAK1
Genes: JAK1A; JTK3
Study 33089619 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 35142560 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 34059090 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 36038984 — Safety Biomarker (SAF): Hyaluronic acid
Study 33093133 — Surrogate Endpoint (SUR): Blood pressure
Study 32313940 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 35102203 — Predictive Biomarker (PRD): GSR mRNA
Genes: GSR; GLUR; GRD1
Study 36401133 — Safety Biomarker (SAF): PDCD1
Genes: CD279; PD1; hSLE1; PD-1
Study 36401133 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 33499572 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 33277845 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 33277845 — Safety Biomarker (SAF): Aminopeptidase N
Genes: ANPEP; APN; CD13; PEPN
Study 34344672 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 34076333 — Surrogate Endpoint (SUR): Blood pressure
Study 35765728 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 32235839 — Surrogate Endpoint (SUR): Serum creatinine
Study 34180245 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 32086599 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 35356935 — Surrogate Endpoint (SUR): Blood pressure
Study 35873768 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 33115487 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 34420261 — Surrogate Endpoint (SUR): Probing pocket depth
Study 34420261 — Safety Biomarker (SAF): Interleukin 1
Study 33855355 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 36260786 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 36288581 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 33824389 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 33824389 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 36038003 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 34606933 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 34491446 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 33755280 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 32730216 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 33794293 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 33794293 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 33794293 — Pharmacodynamic Biomarker (PDY): Retinoblastoma-associated protein
Genes: RB1
Study 33794293 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 32046384 — Predictive Biomarker (PRD): PGR mRNA
Genes: PGR; NR3C3
Study 32046384 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 32046384 — Predictive Biomarker (PRD): KLF9 mRNA
Genes: KLF9; BTEB; BTEB1
Study 32046384 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 32046384 — Predictive Biomarker (PRD): KLF4 mRNA
Genes: KLF4; EZF; GKLF
Study 32046384 — Predictive Biomarker (PRD): DKK1 mRNA
Genes: DKK1; UNQ492/PRO1008
Study 35557278 — Predictive Biomarker (PRD): LOX mRNA
Genes: LOX
Study 32827501 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 32810383 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 35960044 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 36163987 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 36163987 — Predictive Biomarker (PRD): IRAK1 mRNA
Genes: IRAK1; IRAK
Study 36163987 — Predictive Biomarker (PRD): JAK1 mRNA
Genes: JAK1; JAK1A; JAK1B
Study 34533774 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34533774 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 33605982 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 32173896 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 32173896 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 36386386 — Surrogate Endpoint (SUR): Blood pressure
Study 32544773 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 35416361 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 33390054 — Surrogate Endpoint (SUR): Blood pressure
Study 32447799 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 32447799 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 33540180 — Surrogate Endpoint (SUR): Forced vital capacity
Study 33852720 — Monitoring Biomarker (MOI): Macrophage inflammatory protein 1-alpha
Genes: CCL3; G0S19-1; MIP1A; SCYA3
Study 33852720 — Monitoring Biomarker (MOI): C-C motif chemokine 4
Genes: CCL4; LAG1; MIP1B; SCYA4
Study 33852720 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 33852720 — Predictive Biomarker (PRD): CD8A mRNA
Genes: CD8A; MAL
Study 33852720 — Predictive Biomarker (PRD): CRTAM mRNA
Genes: CRTAM
Study 33852720 — Predictive Biomarker (PRD): GZMA mRNA
Genes: GZMA; CTLA3; HFSP
Study 33852720 — Predictive Biomarker (PRD): ADGRG1 mRNA
Genes: ADGRG1; GPR56; TM7LN4; TM7XN1; UNQ540/PRO1083
Study 33852720 — Safety Biomarker (SAF): Arginase-1
Genes: ARG1
Study 33852720 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 33871602 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): C-X-C motif chemokine 9
Genes: CXCL9; CMK; MIG; SCYB9
Study 35276669 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 37597578 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 37597578 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 37597578 — Predictive Biomarker (PRD): CDK4 mRNA
Genes: CDK4
Study 37597578 — Predictive Biomarker (PRD): ERBB3 mRNA
Genes: ERBB3; HER3
Study 37597578 — Predictive Biomarker (PRD): PIK3CA mRNA
Genes: PIK3CA
Study 37597578 — Predictive Biomarker (PRD): Hormone receptor
Study 37597578 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 33628717 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 33628717 — Surrogate Endpoint (SUR): Forced vital capacity
Study 33780806 — Predictive Biomarker (PRD): DAP mRNA
Genes: DAP; DAP1
Study 34498370 — Predictive Biomarker (PRD): TRIT1 mRNA
Genes: TRIT1; IPT; MOD5
Study 32472417 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 32472417 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 32472417 — Predictive Biomarker (PRD): Hormone receptor
Study 34051342 — Surrogate Endpoint (SUR): Blood pressure
Study 33113253 — Predictive Biomarker (PRD): PDK4 mRNA
Genes: PDK4; PDHK4
Study 33113253 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 33113253 — Predictive Biomarker (PRD): CLCN1 mRNA
Genes: CLCN1; CLC1
Study 33113253 — Predictive Biomarker (PRD): SLC9A1 mRNA
Genes: SLC9A1; APNH1; NHE1
Study 33113253 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 33113253 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 33325641 — Predictive Biomarker (PRD): DIABLO mRNA
Genes: DIABLO; SMAC
Study 32512517 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 33086160 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 35247334 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 35247334 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 34982157 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 32880572 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 32936480 — Predictive Biomarker (PRD): MMP2 mRNA
Genes: MMP2; CLG4A
Study 32936480 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 32936480 — Predictive Biomarker (PRD): MMP14 mRNA
Genes: MMP14
Study 32936480 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 35083238 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 34499672 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 33283636 — Monitoring Biomarker (MOI): Angiopoietin 1 receptor
Genes: TEK; TIE2; VMCM; VMCM1
Study 35749373 — Predictive Biomarker (PRD): GDA mRNA
Genes: GDA; KIAA1258
Study 33481401 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 33420349 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 32920492 — Predictive Biomarker (PRD): DSP mRNA
Genes: DSP
Study 34127092 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 34127092 — Surrogate Endpoint (SUR): Blood pressure
Study 34850164 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 35937386 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 34793376 — Surrogate Endpoint (SUR): Serum potassium
Study 34793376 — Surrogate Endpoint (SUR): Serum sodium
Study 33471853 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 33185112 — Surrogate Endpoint (SUR): Blood pressure
Study 33743622 — Surrogate Endpoint (SUR): Blood pressure
Study 35946753 — Monitoring Biomarker (MOI): Heme oxygenase 1
Genes: HMOX1; HO; HO1
Study 33844373 — Surrogate Endpoint (SUR): Probing pocket depth
Study 34766590 — Predictive Biomarker (PRD): APOL1 mRNA
Genes: APOL1; APOL
Study 33123089 — Surrogate Endpoint (SUR): Blood pressure
Study 33922546 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 32418845 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 34995992 — Predictive Biomarker (PRD): SH2D1A mRNA
Genes: SH2D1A; DSHP; SAP
Study 34107013 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 33021715 — Surrogate Endpoint (SUR): Blood pressure
Study 33164575 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 32027810 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 36293985 — Surrogate Endpoint (SUR): Blood pressure
Study 33530982 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 33530982 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 33530982 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 35435565 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 34184202 — Predictive Biomarker (PRD): IDE mRNA
Genes: IDE
Study 33830998 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 33612031 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 33612031 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 33612031 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 35717987 — Predictive Biomarker (PRD): Hormone receptor
Study 35717987 — Surrogate Endpoint (SUR): Bone mineral density
Study 36197359 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 36197359 — Predictive Biomarker (PRD): ACTN3 mRNA
Genes: ACTN3
Study 32936981 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 32306797 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 32306797 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 32088370 — Predictive Biomarker (PRD): GATA2 mRNA
Genes: GATA2
Study 32022725 — Surrogate Endpoint (SUR): Blood pressure
Study 32147352 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 36244813 — Surrogate Endpoint (SUR): Serum calcium
Study 34938893 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 32759229 — Surrogate Endpoint (SUR): Blood pressure
Study 32891139 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32891139 — Surrogate Endpoint (SUR): Blood pressure
Study 32891139 — Surrogate Endpoint (SUR): Serum calcium
Study 32816890 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 32816890 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 32816890 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 32816890 — Predictive Biomarker (PRD): Carbonic anhydrase IX
Genes: CA9; G250; MN
Study 32816890 — Predictive Biomarker (PRD): Hypoxia-inducible factor 1-alpha
Genes: HIF1A; BHLHE78; MOP1; PASD8
Study 32816890 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 32816890 — Predictive Biomarker (PRD): AKT3 mRNA
Genes: AKT3; PKBG
Study 32816890 — Predictive Biomarker (PRD): RIGI mRNA
Genes: RIGI; DDX58
Study 32816890 — Predictive Biomarker (PRD): GZMA mRNA
Genes: GZMA; CTLA3; HFSP
Study 35761363 — Surrogate Endpoint (SUR): Blood pressure
Study 36099141 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 35658908 — Predictive Biomarker (PRD): FBP1 mRNA
Genes: FBP1; FBP
Study 35658908 — Predictive Biomarker (PRD): CNR1 mRNA
Genes: CNR1; CNR
Study 34836002 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 34836002 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 35859087 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 32054509 — Predictive Biomarker (PRD): ASL mRNA
Genes: ASL
Study 35239109 — Surrogate Endpoint (SUR): Blood pressure
Study 36235623 — Surrogate Endpoint (SUR): Blood pressure
Study 34529887 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34529887 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 33894218 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 33004464 — Surrogate Endpoint (SUR): Blood pressure
Study 34643713 — Surrogate Endpoint (SUR): Blood pressure
Study 35879748 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 33884468 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 34714961 — Predictive Biomarker (PRD): AGA mRNA
Genes: AGA
Study 34628065 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 32169887 — Predictive Biomarker (PRD): Hormone receptor
Study 33141487 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 33610836 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 33610836 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 33767064 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 35807922 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 33206251 — Predictive Biomarker (PRD): MZB1 mRNA
Genes: MZB1; MEDA7; PACAP; HSPC190
Study 34412070 — Predictive Biomarker (PRD): PAK1 mRNA
Genes: PAK1
Study 34412070 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 34412070 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 33079877 — Surrogate Endpoint (SUR): Blood pressure
Study 33888542 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 32954927 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 32954927 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 32954927 — Predictive Biomarker (PRD): CDK4 mRNA
Genes: CDK4
Study 32954927 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 34339598 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 33027550 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 32076698 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 35301888 — Predictive Biomarker (PRD): ERRFI1 mRNA
Genes: ERRFI1; MIG6
Study 35301888 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 35301888 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 34268884 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 34268884 — Predictive Biomarker (PRD): POU2F1 mRNA
Genes: POU2F1; OCT1; OTF1
Study 34743319 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 34743319 — Predictive Biomarker (PRD): HTR2A mRNA
Genes: HTR2A; HTR2
Study 34743319 — Safety Biomarker (SAF): BDNF
Study 34423676 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 34718628 — Predictive Biomarker (PRD): INSR mRNA
Genes: INSR
Study 35709415 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 32037195 — Predictive Biomarker (PRD): DLL4 mRNA
Genes: DLL4; UNQ1895/PRO4341
Study 32191267 — Predictive Biomarker (PRD): HTRA1 mRNA
Genes: HTRA1; HTRA; PRSS11
Study 32191267 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 32919288 — Predictive Biomarker (PRD): PTCHD3 mRNA
Genes: PTCHD3; PTR
Study 33744963 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 32700217 — Surrogate Endpoint (SUR): Blood pressure
Study 34187117 — Predictive Biomarker (PRD): AIP mRNA
Genes: AIP; XAP2
Study 34187117 — Surrogate Endpoint (SUR): Blood pressure
Study 34187117 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 34927342 — Safety Biomarker (SAF): Hyaluronic acid
Study 34016536 — Surrogate Endpoint (SUR): Blood pressure
Study 35514231 — Predictive Biomarker (PRD): FGF7 mRNA
Genes: FGF7; KGF
Study 33552685 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 33552685 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 33552685 — Predictive Biomarker (PRD): ROS1 mRNA
Genes: ROS1; MCF3; ROS
Study 33552685 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 36038416 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 33872308 — Predictive Biomarker (PRD): FMN1 mRNA
Genes: FMN1; FMN; LD
Study 32383125 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 32415923 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 36307427 — Surrogate Endpoint (SUR): Blood pressure
Study 36307427 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34286837 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34286837 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 36208242 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 36208242 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 36208242 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 34684407 — Predictive Biomarker (PRD): GPR119 mRNA
Genes: GPR119
Study 34684407 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 36223366 — Predictive Biomarker (PRD): IK mRNA
Genes: IK; RED; RER
Study 35917453 — Predictive Biomarker (PRD): FLT3 mRNA
Genes: FLT3; CD135; FLK2; STK1
Study 32981348 — Surrogate Endpoint (SUR): Blood pressure
Study 32267724 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 33434512 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 34391267 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 36170737 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 34332817 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 35105626 — Safety Biomarker (SAF): Hyaluronic acid
Study 32944871 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 35177019 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 32626889 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 32626889 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 36202797 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC6A4 mRNA
Genes: SLC6A4; HTT; SERT
Study 36202797 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 32917627 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 35820703 — Surrogate Endpoint (SUR): Blood pressure
Study 33213284 — Surrogate Endpoint (SUR): Blood pressure
Study 36185576 — Predictive Biomarker (PRD): FHIT mRNA
Genes: FHIT
Study 36185576 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 36185576 — Predictive Biomarker (PRD): CD83 mRNA
Genes: CD83
Study 32830215 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 32830215 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 34138471 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 35579535 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 33090294 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 33090294 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 33090294 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 32936297 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32936297 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 35895759 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP