TrialPanorama/TrialPanorama-database huggingface dataset:
Study 39444039 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 39444874 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 39444881 — Predictive Biomarker (PRD): MIA mRNA
Genes: MIA
Study 39444901 — Predictive Biomarker (PRD): CENPJ mRNA
Genes: CENPJ; CPAP; LAP; LIP1
Study 39445112 — Safety Biomarker (SAF): Interleukin 1
Study 39445439 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39445609 — Surrogate Endpoint (SUR): Blood pressure
Study 39446365 — Predictive Biomarker (PRD): NRAS mRNA
Genes: NRAS; HRAS1
Study 39446377 — Predictive Biomarker (PRD): NRAS mRNA
Genes: NRAS; HRAS1
Study 39446377 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 39446377 — Predictive Biomarker (PRD): HRAS mRNA
Genes: HRAS; HRAS1
Study 39446377 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 39446377 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 39446377 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 39446378 — Predictive Biomarker (PRD): NBN mRNA
Genes: NBN; NBS; NBS1; P95
Study 39446605 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 39446647 — Predictive Biomarker (PRD): ARSB mRNA
Genes: ARSB
Study 39447053 — Safety Biomarker (SAF): Coagulation factor IIa
Genes: F2
Study 39447094 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 39447530 — Pharmacodynamic Biomarker (PDY): Transmembrane glycoprotein NMB
Genes: GPNMB; HGFIN; NMB; UNQ1725/PRO9925
Study 39447587 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 39447813 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 39447871 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 39448200 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 39448216 — Surrogate Endpoint (SUR): Blood pressure
Study 39448911 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 39450683 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 39452487 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 39452892 — Predictive Biomarker (PRD): JAK1
Genes: JAK1A; JTK3
Study 39453357 — Surrogate Endpoint (SUR): Serum uric acid
Study 39453735 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 39453837 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 39454196 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 39454281 — Surrogate Endpoint (SUR): Serum asparaginase
Study 39454617 — Predictive Biomarker (PRD): S1PR1 mRNA
Genes: S1PR1; CHEDG1; EDG1
Study 39455065 — Predictive Biomarker (PRD): JAK1
Genes: JAK1A; JTK3
Study 39455065 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39455575 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 39455575 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 39455996 — Surrogate Endpoint (SUR): Probing pocket depth
Study 39456048 — Surrogate Endpoint (SUR): Blood pressure
Study 39456544 — Monitoring Biomarker (MOI): Procalcitonin
Study 39460694 — Safety Biomarker (SAF): Urinary total protein
Study 39460896 — Predictive Biomarker (PRD): CFP mRNA
Genes: CFP; PFC
Study 39461270 — Predictive Biomarker (PRD): Folate receptor alpha
Genes: FOLR1; FOLR
Study 39461302 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 39461733 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 39461864 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 39461973 — Predictive Biomarker (PRD): TAL1 mRNA
Genes: TAL1; BHLHA17; SCL; TCL5
Study 39461973 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 39461973 — Predictive Biomarker (PRD): let-7b
Genes: MIRLET7B
Study 39462030 — Surrogate Endpoint (SUR): Blood pressure
Study 39462122 — Predictive Biomarker (PRD): CD247 mRNA
Genes: CD247; CD3Z; T3Z; TCRZ
Study 39462122 — Monitoring Biomarker (MOI): Tissue transglutaminase
Genes: TGM2
Study 39462240 — Surrogate Endpoint (SUR): Blood pressure
Study 39463748 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 39463748 — Predictive Biomarker (PRD): CDK4 mRNA
Genes: CDK4
Study 39463748 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39463748 — Predictive Biomarker (PRD): Hormone receptor
Study 39463748 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 39464260 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 39465257 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 39465257 — Surrogate Endpoint (SUR): Pathological complete response
Study 39467244 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39468444 — Surrogate Endpoint (SUR): Blood pressure
Study 39468592 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 39468592 — Surrogate Endpoint (SUR): Serum creatinine
Study 39468643 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 39468643 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39468643 — Safety Biomarker (SAF): miR-133a
Study 39468643 — Safety Biomarker (SAF): miR-155
Genes: MIR155
Study 39468649 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 39469641 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 39469838 — Predictive Biomarker (PRD): TACSTD2 mRNA
Genes: TACSTD2; GA733-1; M1S1; TROP2
Study 39470058 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 39470058 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 39470284 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 39470695 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 39470878 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 39471078 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 39471424 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 39471440 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 39471475 — Predictive Biomarker (PRD): CLN3 mRNA
Genes: CLN3; BTS
Study 39472058 — Predictive Biomarker (PRD); Safety Biomarker (SAF): STAR mRNA
Genes: STAR; STARD1
Study 39472200 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 39472200 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39472354 — Monitoring Biomarker (MOI): Urokinase plasminogen activator surface receptor
Genes: PLAUR; MO3; UPAR
Study 39472768 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 39472768 — Predictive Biomarker (PRD): GLS mRNA
Genes: GLS; GLS1; KIAA0838
Study 39473003 — Safety Biomarker (SAF): Hyaluronic acid
Study 39473014 — Predictive Biomarker (PRD): MCC mRNA
Genes: MCC
Study 39473396 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 39473503 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 39474371 — Safety Biomarker (SAF): Complement factor D
Genes: CFD; DF; PFD
Study 39474856 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39475418 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39475418 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 39475418 — Predictive Biomarker (PRD): Hormone receptor
Study 39475591 — Predictive Biomarker (PRD): PLK1 mRNA
Genes: PLK1; PLK
Study 39475859 — Pharmacodynamic Biomarker (PDY): Signal transducer and activator of transcription 3
Genes: STAT3; APRF
Study 39475859 — Predictive Biomarker (PRD): SOCS3 mRNA
Genes: SOCS3; CIS3; SSI3
Study 39475859 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 39475859 — Safety Biomarker (SAF): IL-6 and IL-10
Study 39476073 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 39476124 — Predictive Biomarker (PRD): GPRC5D mRNA
Genes: GPRC5D
Study 39476124 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 39477271 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 39477631 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 39477835 — Predictive Biomarker (PRD): MTR mRNA
Genes: MTR
Study 39478168 — Predictive Biomarker (PRD): GRIN1 mRNA
Genes: GRIN1; NMDAR1
Study 39478521 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 39478672 — Monitoring Biomarker (MOI): HBV DNA
Study 39479003 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 39479329 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 39480424 — Surrogate Endpoint (SUR): Bone mineral density
Study 39480453 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 39480530 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 39480645 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39480645 — Monitoring Biomarker (MOI): Urokinase plasminogen activator surface receptor
Genes: PLAUR; MO3; UPAR
Study 39480670 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 39480764 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 39480764 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 39480764 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Neurofilament light polypeptide
Genes: NEFL; NF68; NFL
Study 39481395 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 39481395 — Predictive Biomarker (PRD): Hormone receptor
Study 39481425 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 39482484 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 39482707 — Monitoring Biomarker (MOI): Cell-free DNA
Study 39482712 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 39482774 — Surrogate Endpoint (SUR): Blood pressure
Study 39483517 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 39483619 — Predictive Biomarker (PRD): FMR1
Genes: FMRP; FRAXA; MGC87458
Study 39483619 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 39484118 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39484239 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 39485256 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 39485760 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39486046 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 39486046 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 39486432 — Predictive Biomarker (PRD): EZH2 mRNA
Genes: EZH2; KMT6
Study 39486432 — Predictive Biomarker (PRD): EZH2
Genes: EZH1; ENX-1; KMT6; KMT6A
Study 39486433 — Predictive Biomarker (PRD): EZH2 mRNA
Genes: EZH2; KMT6
Study 39486433 — Predictive Biomarker (PRD): EZH2
Genes: EZH1; ENX-1; KMT6; KMT6A
Study 39486824 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 39486886 — Predictive Biomarker (PRD): STAT1 mRNA
Genes: STAT1
Study 39486886 — Predictive Biomarker (PRD): GSDME mRNA
Genes: GSDME; DFNA5; ICERE1
Study 39486886 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 39487320 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 39487428 — Surrogate Endpoint (SUR): Blood pressure
Study 39487428 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 39487920 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 39487920 — Surrogate Endpoint (SUR): Bone mineral density
Study 39488230 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 39488255 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 39488549 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 39488549 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39488549 — Predictive Biomarker (PRD): Hormone receptor
Study 39488825 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 39489541 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 39489541 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Tumor mutational burden
Study 39489747 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 39489747 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 39489895 — Predictive Biomarker (PRD): PDGFRB mRNA
Genes: PDGFRB; PDGFR; PDGFR1
Study 39489895 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 39489924 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 39489924 — Predictive Biomarker (PRD): Homologous recombination deficiency
Study 39489924 — Predictive Biomarker (PRD): Hormone receptor
Study 39490971 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 39490985 — Surrogate Endpoint (SUR): Blood pressure
Study 39490985 — Surrogate Endpoint (SUR): Serum creatinine
Study 39491572 — Predictive Biomarker (PRD): PTS mRNA
Genes: PTS
Study 39491719 — Predictive Biomarker (PRD): MC1R mRNA
Genes: MC1R; MSHR
Study 39492363 — Predictive Biomarker (PRD): IVL mRNA
Genes: IVL
Study 39492655 — Surrogate Endpoint (SUR): Blood pressure
Study 39493888 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39494565 — Surrogate Endpoint (SUR): Blood pressure
Study 39494843 — Surrogate Endpoint (SUR): Blood pressure
Study 39495056 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 39495136 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 39495154 — Predictive Biomarker (PRD): CLK1 mRNA
Genes: CLK1; CLK
Study 39495154 — Predictive Biomarker (PRD): DYRK1A mRNA
Genes: DYRK1A; DYRK; MNB; MNBH
Study 39495154 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 39495175 — Predictive Biomarker (PRD): CLEC9A mRNA
Genes: CLEC9A; UNQ9341/PRO34046
Study 39497092 — Safety Biomarker (SAF): Transforming growth factor beta 1
Genes: TGFB1; TGFB
Study 39497616 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 39497947 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 39497947 — Surrogate Endpoint (SUR): Blood pressure
Study 39498340 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 39498443 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 39498822 — Surrogate Endpoint (SUR): Blood pressure
Study 39499142 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39499299 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 39499299 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 39501388 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 39501388 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 39501388 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39501801 — Predictive Biomarker (PRD): IGLL5 mRNA
Genes: IGLL5
Study 39501801 — Predictive Biomarker (PRD): IRF4 mRNA
Genes: IRF4; MUM1
Study 39501801 — Predictive Biomarker (PRD): CREBBP mRNA
Genes: CREBBP; CBP
Study 39501801 — Predictive Biomarker (PRD): ERBB4 mRNA
Genes: ERBB4; HER4
Study 39501801 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 39501831 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 39502777 — Predictive Biomarker (PRD): DAP mRNA
Genes: DAP; DAP1
Study 39502777 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 39502777 — Surrogate Endpoint (SUR): Blood pressure
Study 39503055 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 39503605 — Predictive Biomarker (PRD): DCLRE1C mRNA
Genes: DCLRE1C; ARTEMIS; ASCID; SCIDA; SNM1C
Study 39503770 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 39503798 — Surrogate Endpoint (SUR): Blood pressure
Study 39503807 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 39504016 — Surrogate Endpoint (SUR): Blood pressure
Study 39504933 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Neurofilament light polypeptide
Genes: NEFL; NF68; NFL
Study 39505123 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 39506539 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 39506856 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 39506905 — Predictive Biomarker (PRD): RHOF mRNA
Genes: RHOF; ARHF; RIF
Study 39507037 — Safety Biomarker (SAF): PDCD1
Genes: CD279; PD1; hSLE1; PD-1
Study 39507039 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 39508145 — Surrogate Endpoint (SUR): Blood pressure
Study 39509008 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39509672 — Predictive Biomarker (PRD): Hormone receptor
Study 39509672 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 39509708 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 39509711 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39509838 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 39510586 — Predictive Biomarker (PRD): CD70 mRNA
Genes: CD70; CD27L; CD27LG; TNFSF7
Study 39510727 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 39510786 — Predictive Biomarker (PRD): TPI1 mRNA
Genes: TPI1; TPI
Study 39511203 — Predictive Biomarker (PRD): NLRP3 mRNA
Genes: NLRP3; C1orf7; CIAS1; NALP3; PYPAF1
Study 39511203 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 1 beta
Genes: IL1B; IL1F2
Study 39511203 — Safety Biomarker (SAF): Interleukin 1
Study 39511473 — Predictive Biomarker (PRD): MCIDAS mRNA
Genes: MCIDAS; IDAS; MCI; MCIN
Study 39511506 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 39511506 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 39511611 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Growth/differentiation factor 15
Genes: GDF15; MIC1; PDF; PLAB; PTGFB
Study 39511836 — Surrogate Endpoint (SUR): Sperm parameters
Study 39512280 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 39512897 — Predictive Biomarker (PRD): HPSE mRNA
Genes: HPSE; HEP; HPA; HPA1; HPR1; HPSE1; HSE1
Study 39513023 — Predictive Biomarker (PRD): CD52 mRNA
Genes: CD52; CDW52; HE5
Study 39513186 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): FasL mRNA
Genes: FASLG; APT1LG1; CD95L; FASL; TNFSF6
Study 39513267 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 39513363 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 39513363 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 39513363 — Monitoring Biomarker (MOI): Macrophage inflammatory protein 1-alpha
Genes: CCL3; G0S19-1; MIP1A; SCYA3
Study 39513363 — Monitoring Biomarker (MOI): C-C motif chemokine 4
Genes: CCL4; LAG1; MIP1B; SCYA4
Study 39513363 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 39513363 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 39513363 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 39513363 — Predictive Biomarker (PRD): Hypoxia-inducible factor 1-alpha
Genes: HIF1A; BHLHE78; MOP1; PASD8
Study 39513382 — Pharmacodynamic Biomarker (PDY): Histone acetylation
Study 39513407 — Predictive Biomarker (PRD); Safety Biomarker (SAF): ABCG2
Genes: EST157481; MXR; BCRP; ABCP; CD338
Study 39513754 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 39513754 — Predictive Biomarker (PRD): GFAP mRNA
Genes: GFAP
Study 39513754 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Chitinase-3-like protein 1
Genes: CHI3L1
Study 39514000 — Surrogate Endpoint (SUR): Blood pressure
Study 39514025 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 39514051 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 39514051 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 39514051 — Safety Biomarker (SAF): Cytotoxic T-lymphocyte protein 4
Genes: CTLA4; CD152
Study 39514692 — Surrogate Endpoint (SUR): Serum creatinine
Study 39515580 — Predictive Biomarker (PRD): MAP3K10 mRNA
Genes: MAP3K10; MLK2; MST
Study 39515756 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 39516087 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 39516358 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 39516643 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 39516847 — Surrogate Endpoint (SUR): Blood pressure
Study 39517110 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 39520516 — Predictive Biomarker (PRD): FAP mRNA
Genes: FAP
Study 39520738 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 39520738 — Predictive Biomarker (PRD): Homologous recombination deficiency
Study 39520893 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 39521094 — Predictive Biomarker (PRD): ESD mRNA
Genes: ESD
Study 39521884 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 39521884 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Tumor mutational burden