TrialPanorama/TrialPanorama-database huggingface dataset:
Study 35586674 — Predictive Biomarker (PRD): NLRP3 mRNA
Genes: NLRP3; C1orf7; CIAS1; NALP3; PYPAF1
Study 35586674 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 35586674 — Safety Biomarker (SAF): miR-155
Genes: MIR155
Study 32662323 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 35251396 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 35251396 — Safety Biomarker (SAF): XRCC1
Genes: RCC
Study 33275152 — Surrogate Endpoint (SUR): Serum creatinine
Study 34628865 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 32442195 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 32442195 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 33663414 — Predictive Biomarker (PRD): MCAT mRNA
Genes: MCAT; MT
Study 32171064 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 36069038 — Predictive Biomarker (PRD): PPT1 mRNA
Genes: PPT1; CLN1; PPT
Study 32144911 — Predictive Biomarker (PRD): SP9 mRNA
Genes: SP9
Study 32144911 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 32144911 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 32144911 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 34384793 — Predictive Biomarker (PRD): DAP mRNA
Genes: DAP; DAP1
Study 34384793 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 34384793 — Surrogate Endpoint (SUR): Blood pressure
Study 33813850 — Surrogate Endpoint (SUR): Blood pressure
Study 33131470 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 33131470 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 33228562 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 32886212 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 35803757 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 32343642 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 32006758 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 34398011 — Surrogate Endpoint (SUR): Blood pressure
Study 32982204 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 33418951 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 35291435 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 32146550 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 34417416 — Predictive Biomarker (PRD): HGS mRNA
Genes: HGS; HRS
Study 32894625 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 32081564 — Predictive Biomarker (PRD): KLRK1 mRNA
Genes: KLRK1; D12S2489E; NKG2D
Study 32081564 — Predictive Biomarker (PRD): KLRC1 mRNA
Genes: KLRC1; NKG2A
Study 32081564 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 35843540 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 35843540 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 35897098 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 32737004 — Predictive Biomarker (PRD): CCND1 mRNA
Genes: CCND1; BCL1; PRAD1
Study 32737004 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 33217054 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 33217054 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 34280355 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 33262576 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 33262576 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 33237140 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 33237140 — Safety Biomarker (SAF): Reactive oxygen species
Study 33237140 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 33585378 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 32630214 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 32630214 — Surrogate Endpoint (SUR): Blood pressure
Study 32462746 — Safety Biomarker (SAF): Reactive oxygen species
Study 35286322 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 36302537 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 36302537 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 36302537 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 36302537 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 36302537 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 32641154 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32165251 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 34364165 — Predictive Biomarker (PRD): MLH1 mRNA
Genes: MLH1; COCA2
Study 34364165 — Predictive Biomarker (PRD): GFI1 mRNA
Genes: GFI1; ZNF163
Study 34364165 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 35365239 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 35365239 — Predictive Biomarker (PRD): TH mRNA
Genes: TH; TYH
Study 35946280 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 35145945 — Surrogate Endpoint (SUR): Blood pressure
Study 33086597 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 33086597 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 34514494 — Predictive Biomarker (PRD): INVS mRNA
Genes: INVS; INV; NPHP2
Study 34147344 — Surrogate Endpoint (SUR): Blood pressure
Study 34370319 — Safety Biomarker (SAF): Hydroxyphenylpyruvate dioxygenase
Genes: HPD; PPD
Study 32595599 — Surrogate Endpoint (SUR): Blood pressure
Study 32595599 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 35272405 — Surrogate Endpoint (SUR): Forced vital capacity
Study 32314970 — Surrogate Endpoint (SUR): Blood pressure
Study 33795393 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 33795393 — Predictive Biomarker (PRD): Coagulation factor VIII
Genes: F8; F8C
Study 35347555 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 32920973 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 32920973 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 32037273 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 32037273 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 32037273 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 32037273 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 36268379 — Surrogate Endpoint (SUR): Blood pressure
Study 32988519 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 34463415 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 34463415 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 35993803 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 32402585 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 32402585 — Surrogate Endpoint (SUR): Blood pressure
Study 32600919 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 35736394 — Predictive Biomarker (PRD): GFRA2 mRNA
Genes: GFRA2; GDNFRB; RETL2; TRNR2
Study 32144165 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 32883567 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 32883567 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 32367561 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 34474590 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 34474590 — Surrogate Endpoint (SUR): Serum creatinine
Study 34474590 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 35821400 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 35821400 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 35821400 — Predictive Biomarker (PRD): Hypoxia-inducible factor 1-alpha
Genes: HIF1A; BHLHE78; MOP1; PASD8
Study 35821400 — Safety Biomarker (SAF): Interleukin 1
Study 36342059 — Surrogate Endpoint (SUR): Blood pressure
Study 33444161 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 35643381 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 35643381 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 32422234 — Predictive Biomarker (PRD): TMPRSS6 mRNA
Genes: TMPRSS6; UNQ354/PRO618
Study 35001671 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 35534778 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 34355628 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 37458100 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 32988521 — Surrogate Endpoint (SUR): Serum calcium
Study 34076495 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 34076495 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 34076495 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 32270637 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 35195725 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 33547453 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 33222190 — Monitoring Biomarker (MOI): HBV DNA
Study 32412991 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 35807872 — Surrogate Endpoint (SUR): Blood pressure
Study 34855513 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 33185651 — Surrogate Endpoint (SUR): Blood pressure
Study 33185651 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 35768804 — Predictive Biomarker (PRD): HMOX2 mRNA
Genes: HMOX2; HO2
Study 35768804 — Predictive Biomarker (PRD): CALCOCO2 mRNA
Genes: CALCOCO2; NDP52
Study 35768804 — Predictive Biomarker (PRD): ZNF440 mRNA
Genes: ZNF440
Study 35768804 — Predictive Biomarker (PRD): CLCC1 mRNA
Genes: CLCC1; KIAA0761; MCLC
Study 35768804 — Predictive Biomarker (PRD): CHMP3 mRNA
Genes: CHMP3; CGI149; NEDF; VPS24; CGI-149
Study 32712966 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 35537858 — Predictive Biomarker (PRD): CNR1 mRNA
Genes: CNR1; CNR
Study 35537858 — Predictive Biomarker (PRD): CBR1 mRNA
Genes: CBR1; CBR; CRN; SDR21C1
Study 35537858 — Pharmacodynamic Biomarker (PDY): Fatty acid amide hydrolase 1
Genes: FAAH; FAAH1
Study 32928870 — Predictive Biomarker (PRD): Hormone receptor
Study 36202899 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 36202899 — Predictive Biomarker (PRD): CLEC9A mRNA
Genes: CLEC9A; UNQ9341/PRO34046
Study 36202899 — Predictive Biomarker (PRD): TAB2 mRNA
Genes: TAB2; KIAA0733; MAP3K7IP2
Study 36202899 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Tumor mutational burden
Study 32182774 — Predictive Biomarker (PRD): ADORA2A mRNA
Genes: ADORA2A; ADORA2
Study 32182774 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 32182774 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 33832949 — Predictive Biomarker (PRD): PDGFRB mRNA
Genes: PDGFRB; PDGFR; PDGFR1
Study 32933755 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 33576284 — Surrogate Endpoint (SUR): Blood pressure
Study 32828187 — Surrogate Endpoint (SUR): Blood pressure
Study 33462619 — Surrogate Endpoint (SUR): Bone mineral density
Study 32831169 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 34496940 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 33442031 — Surrogate Endpoint (SUR): Blood pressure
Study 32054731 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 32054731 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 32054731 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 35879008 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 32631405 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32631405 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 32631405 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 33820701 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 33820701 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 33820701 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 34687130 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 35487727 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 35487727 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 35911661 — Predictive Biomarker (PRD): SLC26A3 mRNA
Genes: SLC26A3; DRA
Study 35323052 — Predictive Biomarker (PRD): LAMA1 mRNA
Genes: LAMA1; LAMA
Study 35323052 — Surrogate Endpoint (SUR): Forced vital capacity
Study 33742764 — Predictive Biomarker (PRD): TLR7 mRNA
Genes: TLR7; UNQ248/PRO285
Study 35673907 — Predictive Biomarker (PRD): AKT1 mRNA
Genes: AKT1; PKB; RAC
Study 35673907 — Predictive Biomarker (PRD): CASP3 mRNA
Genes: CASP3; CPP32
Study 35673907 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 35673907 — Predictive Biomarker (PRD): JUN mRNA
Genes: JUN
Study 35673907 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 33400943 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 33400943 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 33400943 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 34579074 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 34579074 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 32377523 — Pharmacodynamic Biomarker (PDY): Insulin receptor substrate 1
Genes: IRS1
Study 32377523 — Predictive Biomarker (PRD): AKT1 mRNA
Genes: AKT1; PKB; RAC
Study 33727090 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 33727090 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 37384576 — Predictive Biomarker (PRD): OXTR mRNA
Genes: OXTR
Study 35552930 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 34579097 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 34579097 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 34579097 — Surrogate Endpoint (SUR): Blood pressure
Study 34579097 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 35978182 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 33645201 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Osteopontin
Genes: SPP1; BNSP; OPN; PSEC0156
Study 33645201 — Surrogate Endpoint (SUR): Bone mineral density
Study 34533487 — Surrogate Endpoint (SUR): Blood pressure
Study 34491291 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 32491239 — Predictive Biomarker (PRD): GPC3 mRNA
Genes: GPC3; OCI5
Study 32491239 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 33453563 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 32819923 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 35322711 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 35322711 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 33476534 — Surrogate Endpoint (SUR): Blood pressure
Study 34434228 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 34434228 — Safety Biomarker (SAF): BDNF
Study 32040883 — Predictive Biomarker (PRD): VIM mRNA
Genes: VIM
Study 33237533 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34391963 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 34391963 — Surrogate Endpoint (SUR): Bone mineral density
Study 32584384 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 32023608 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 33397449 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32054284 — Surrogate Endpoint (SUR): Blood pressure
Study 33127746 — Predictive Biomarker (PRD): KLF4 mRNA
Genes: KLF4; EZF; GKLF
Study 33127746 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MUC5AC mRNA
Genes: MUC5AC; MUC5
Study 33127746 — Pharmacodynamic Biomarker (PDY): Signal transducer and activator of transcription 3
Genes: STAT3; APRF
Study 32493514 — Monitoring Biomarker (MOI): Procalcitonin
Study 35331538 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34441755 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 34441755 — Predictive Biomarker (PRD): RALA mRNA
Genes: RALA; RAL
Study 34441755 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 32121218 — Surrogate Endpoint (SUR): Blood pressure
Study 33580200 — Predictive Biomarker (PRD): NRAS mRNA
Genes: NRAS; HRAS1
Study 32398441 — Surrogate Endpoint (SUR): Blood pressure
Study 34116700 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 33544937 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 32182123 — Predictive Biomarker (PRD): SLC5A1 mRNA
Genes: SLC5A1; NAGT; SGLT1
Study 32182123 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 32182123 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 33971386 — Predictive Biomarker (PRD): Hormone receptor
Study 34487844 — Surrogate Endpoint (SUR): Blood pressure
Study 34487844 — Surrogate Endpoint (SUR): Serum creatinine
Study 35108029 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 32706261 — Safety Biomarker (SAF): Reactive oxygen species
Study 32706261 — Surrogate Endpoint (SUR): Blood pressure
Study 32706261 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 34737837 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34737837 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 33185628 — Predictive Biomarker (PRD): DAP mRNA
Genes: DAP; DAP1
Study 32203453 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 33847047 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 35772665 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 33033962 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 33033962 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 35274413 — Predictive Biomarker (PRD): GAL3ST1 mRNA
Genes: GAL3ST1; CST
Study 32187881 — Predictive Biomarker (PRD): SLC5A1 mRNA
Genes: SLC5A1; NAGT; SGLT1
Study 32187881 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 34708640 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 34708640 — Surrogate Endpoint (SUR): Serum uric acid
Study 33609072 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 33505154 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 34608769 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 36414504 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 36414504 — Predictive Biomarker (PRD): COMP mRNA
Genes: COMP
Study 36414504 — Safety Biomarker (SAF): Hyaluronic acid
Study 34463234 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC6A4 mRNA
Genes: SLC6A4; HTT; SERT
Study 34239129 — Pharmacodynamic Biomarker (PDY): Histone acetylation
Study 32929463 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 32118723 — Surrogate Endpoint (SUR): Blood pressure
Study 34551907 — Predictive Biomarker (PRD): DNMT1 mRNA
Genes: DNMT1; AIM; CXXC9; DNMT
Study 34551907 — Predictive Biomarker (PRD): Apoptosis regulator Bcl-2
Genes: BCL2
Study 32941737 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 35014217 — Predictive Biomarker (PRD): DLK1 mRNA
Genes: DLK1; DLK
Study 35014217 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Neurofilament light polypeptide
Genes: NEFL; NF68; NFL
Study 35014217 — Safety Biomarker (SAF): c-Jun N-terminal kinase
Study 32456442 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 35599154 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 32000724 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1