TrialPanorama/TrialPanorama-database huggingface dataset:
Study 15008034 — Surrogate Endpoint (SUR): Blood pressure
Study 7517829 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3139326 — Surrogate Endpoint (SUR): Blood pressure
Study 24957913 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14644393 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 14644393 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 14644393 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10770982 — Predictive Biomarker (PRD): Hormone receptor
Study 27983572 — Predictive Biomarker (PRD): INSR mRNA
Genes: INSR
Study 27983572 — Predictive Biomarker (PRD): LDHA mRNA
Genes: LDHA; PIG19
Study 27983572 — Predictive Biomarker (PRD): MYC mRNA
Genes: MYC; BHLHE39
Study 27983572 — Predictive Biomarker (PRD): HIF1AN mRNA
Genes: HIF1AN; FIH1
Study 24583055 — Surrogate Endpoint (SUR): Blood pressure
Study 22665533 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 19570717 — Predictive Biomarker (PRD): CSAD mRNA
Genes: CSAD; CSD
Study 3986859 — Surrogate Endpoint (SUR): Blood pressure
Study 29224502 — Predictive Biomarker (PRD): Lymphocyte activation antigen CD30
Genes: TNFRSF8; CD30; D1S166E
Study 20233853 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 10613592 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 28831548 — Predictive Biomarker (PRD): AQP4 mRNA
Genes: AQP4
Study 1680327 — Surrogate Endpoint (SUR): Forced vital capacity
Study 26433562 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 30707225 — Predictive Biomarker (PRD): FGR mRNA
Genes: FGR; SRC2
Study 20413364 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20413364 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10202826 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10202826 — Predictive Biomarker (PRD): CD27 mRNA
Genes: CD27; TNFRSF7
Study 10202826 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 26713003 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17383264 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31996614 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 25907848 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 8658370 — Surrogate Endpoint (SUR): Serum potassium
Study 1380609 — Surrogate Endpoint (SUR): Blood pressure
Study 30836981 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24429541 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20714165 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 11169006 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 2532459 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2532459 — Surrogate Endpoint (SUR): Blood pressure
Study 30810382 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 25115430 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25115430 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25115430 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 25115430 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 25115430 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 22228446 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9559452 — Surrogate Endpoint (SUR): Blood pressure
Study 25952257 — Surrogate Endpoint (SUR): Serum creatinine
Study 22906516 — Predictive Biomarker (PRD): DBH mRNA
Genes: DBH
Study 17112805 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 10376178 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8721527 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 22014414 — Surrogate Endpoint (SUR): Blood pressure
Study 22014414 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22014414 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21041707 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 18251647 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Osteopontin
Genes: SPP1; BNSP; OPN; PSEC0156
Study 18251647 — Predictive Biomarker (PRD): PDGFA mRNA
Genes: PDGFA; PDGF1
Study 11151741 — Surrogate Endpoint (SUR): Blood pressure
Study 8360369 — Predictive Biomarker (PRD): GSR mRNA
Genes: GSR; GLUR; GRD1
Study 26938752 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 26938752 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26938752 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 18416476 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18416476 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16030279 — Surrogate Endpoint (SUR): Serum creatinine
Study 30858255 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27903289 — Predictive Biomarker (PRD): MCIDAS mRNA
Genes: MCIDAS; IDAS; MCI; MCIN
Study 8972541 — Surrogate Endpoint (SUR): Blood pressure
Study 1462910 — Predictive Biomarker (PRD): MVP mRNA
Genes: MVP; LRP
Study 30501824 — Predictive Biomarker (PRD): TTN mRNA
Genes: TTN
Study 12198662 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 24463982 — Surrogate Endpoint (SUR): Blood pressure
Study 24463982 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 22766993 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 22766993 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 22766993 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17513398 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17513398 — Surrogate Endpoint (SUR): Blood pressure
Study 11820660 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 15981753 — Surrogate Endpoint (SUR): Blood pressure
Study 23611172 — Surrogate Endpoint (SUR): Blood pressure
Study 21369370 — Surrogate Endpoint (SUR): Blood pressure
Study 19470677 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 11317704 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 20851591 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 22273718 — Predictive Biomarker (PRD): WT1 mRNA
Genes: WT1
Study 19395583 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 19216850 — Monitoring Biomarker (MOI): Procalcitonin
Study 29785103 — Predictive Biomarker (PRD): SRI mRNA
Genes: SRI
Study 18721243 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31132798 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21069377 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25637322 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22453059 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16380496 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 12791815 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 6323783 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 6323783 — Predictive Biomarker (PRD): CPA1 mRNA
Genes: CPA1; CPA
Study 19632961 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 15090768 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28424510 — Surrogate Endpoint (SUR): Blood pressure
Study 24090379 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 21355151 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18469241 — Predictive Biomarker (PRD): SAT1 mRNA
Genes: SAT1; SAT
Study 10852611 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 9583629 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 24748465 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 10071289 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 27838572 — Predictive Biomarker (PRD): SRI mRNA
Genes: SRI
Study 18257350 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 18257350 — Predictive Biomarker (PRD): TSPAN31 mRNA
Genes: TSPAN31; SAS
Study 14504947 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 14504947 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 7467565 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 31748227 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19443354 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 19443354 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 19443354 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 25678302 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 17101640 — Surrogate Endpoint (SUR): Blood pressure
Study 16281663 — Predictive Biomarker (PRD): COPE mRNA
Genes: COPE
Study 9416856 — Predictive Biomarker (PRD): CYCS mRNA
Genes: CYCS; CYC
Study 9416856 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 3320787 — Surrogate Endpoint (SUR): Blood pressure
Study 31531707 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 29486367 — Predictive Biomarker (PRD): CYP24A1 mRNA
Genes: CYP24A1; CYP24
Study 18979160 — Surrogate Endpoint (SUR): Serum calcium
Study 31669890 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31669890 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 24139833 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24139833 — Surrogate Endpoint (SUR): Blood pressure
Study 22315364 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 20558004 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 20558004 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11297752 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 28340306 — Surrogate Endpoint (SUR): Forced vital capacity
Study 10341274 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 8942890 — Surrogate Endpoint (SUR): Blood pressure
Study 7083750 — Surrogate Endpoint (SUR): Blood pressure
Study 15040645 — Surrogate Endpoint (SUR): Blood pressure
Study 15957718 — Safety Biomarker (SAF): Alpha-glutathione S-transferase
Study 26991622 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26991622 — Safety Biomarker (SAF): IL-6 and IL-10
Study 8092502 — Surrogate Endpoint (SUR): Blood pressure
Study 31037994 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 31037994 — Predictive Biomarker (PRD): VASP mRNA
Genes: VASP
Study 20050764 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 20050764 — Predictive Biomarker (PRD): GNL3 mRNA
Genes: GNL3; E2IG3; NS
Study 16303296 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 11960591 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7555484 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31535199 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26593941 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21352079 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15042114 — Surrogate Endpoint (SUR): Blood pressure
Study 31778277 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 29098841 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21557207 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19943787 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15346657 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 15346657 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 15346657 — Safety Biomarker (SAF): Reactive oxygen species
Study 15346657 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 10708052 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8403956 — Surrogate Endpoint (SUR): Serum potassium
Study 25816336 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17044733 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12929470 — Surrogate Endpoint (SUR): Blood pressure
Study 11071065 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25739317 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 23930843 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 2362257 — Surrogate Endpoint (SUR): Blood pressure
Study 29017451 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 19336551 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 19336551 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 9744776 — Surrogate Endpoint (SUR): Serum creatinine
Study 19926893 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19926893 — Surrogate Endpoint (SUR): Serum potassium
Study 26765317 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 7037048 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 26170627 — Surrogate Endpoint (SUR): Serum uric acid
Study 15096902 — Surrogate Endpoint (SUR): Blood pressure
Study 15096902 — Surrogate Endpoint (SUR): Serum creatinine
Study 2195978 — Surrogate Endpoint (SUR): Blood pressure
Study 28178355 — Predictive Biomarker (PRD): DKK1 mRNA
Genes: DKK1; UNQ492/PRO1008
Study 28178355 — Predictive Biomarker (PRD): SFRP1 mRNA
Genes: SFRP1; FRP; FRP1; SARP2
Study 24296324 — Surrogate Endpoint (SUR): Blood pressure
Study 19132203 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19132203 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17846352 — Surrogate Endpoint (SUR): Blood pressure
Study 2556727 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 25118962 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17522246 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 31060549 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 31060549 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28928175 — Predictive Biomarker (PRD): KLHL17 mRNA
Genes: KLHL17; AF
Study 25769436 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 25769436 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 25769436 — Predictive Biomarker (PRD): MAEA mRNA
Genes: MAEA; EMP; HLC10; PIG5
Study 7527592 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 28893866 — Predictive Biomarker (PRD): BMPR2 mRNA
Genes: BMPR2; PPH1
Study 22572984 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 18631168 — Predictive Biomarker (PRD): CREG1 mRNA
Genes: CREG1; CREG; UNQ727/PRO1409
Study 30838890 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-122
Genes: MIR122
Study 19249414 — Surrogate Endpoint (SUR): Blood pressure
Study 15114056 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 1369707 — Surrogate Endpoint (SUR): Blood pressure
Study 9737124 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23601071 — Predictive Biomarker (PRD): PPOX mRNA
Genes: PPOX
Study 23601071 — Safety Biomarker (SAF): PPOX
Genes: HCRT; OX
Study 23601071 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 23343596 — Predictive Biomarker (PRD): AMPH mRNA
Genes: AMPH; AMPH1
Study 15213032 — Predictive Biomarker (PRD): SLC6A3 mRNA
Genes: SLC6A3; DAT1
Study 11591194 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 2655907 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2655907 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26282643 — Predictive Biomarker (PRD): MLH1 mRNA
Genes: MLH1; COCA2
Study 26282643 — Predictive Biomarker (PRD): DNA mismatch repair protein MSH2
Genes: MSH2
Study 18260977 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14712346 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14712346 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 22709547 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22709547 — Predictive Biomarker (PRD): CX3CL1 mRNA
Genes: CX3CL1; FKN; NTT; SCYD1; A-152E5.2
Study 22709547 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10596305 — Surrogate Endpoint (SUR): Blood pressure
Study 7717820 — Surrogate Endpoint (SUR): Blood pressure
Study 1746006 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 19818720 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 11778791 — Surrogate Endpoint (SUR): Serum potassium
Study 11778791 — Surrogate Endpoint (SUR): Blood pressure
Study 26662031 — Predictive Biomarker (PRD): UROD mRNA
Genes: UROD
Study 19761514 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 16627810 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 10993781 — Safety Biomarker (SAF): Reactive oxygen species
Study 8638548 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 29401325 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 24457590 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 20969657 — Safety Biomarker (SAF): Hyaluronic acid
Study 15781667 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 3192038 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 3192038 — Surrogate Endpoint (SUR): Blood pressure
Study 3192038 — Safety Biomarker (SAF): Urinary total protein
Study 3192038 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 25912221 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 14741172 — Predictive Biomarker (PRD): MPL mRNA
Genes: MPL; TPOR
Study 14741172 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 14741172 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 9825744 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29045535 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 15145916 — Surrogate Endpoint (SUR): Blood pressure
Study 11387182 — Surrogate Endpoint (SUR): Blood pressure
Study 24499168 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 1823383 — Surrogate Endpoint (SUR): Serum calcium
Study 27639753 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 27682852 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 15926604 — Surrogate Endpoint (SUR): Blood pressure
Study 8700659 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 1909541 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30924894 — Monitoring Biomarker (MOI): Cell-free DNA
Study 30774321 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 15000887 — Safety Biomarker (SAF): Coagulation factor IIa
Genes: F2
Study 24906471 — Surrogate Endpoint (SUR): Blood pressure
Study 21871589 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 21871589 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 16439874 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16439874 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 25831694 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25831694 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25831694 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 25831694 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 25831694 — Safety Biomarker (SAF): IL-6 and IL-10
Study 19131059 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19131059 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 15668606 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15668606 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 12186625 — Predictive Biomarker (PRD): Hormone receptor
Study 8834825 — Predictive Biomarker (PRD): CAST mRNA
Genes: CAST
Study 1674677 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1674677 — Surrogate Endpoint (SUR): Blood pressure
Study 31023525 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23579178 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 23579178 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 12545682 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 25562575 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY