TrialPanorama/TrialPanorama-database huggingface dataset:
Study 24457472 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 24457472 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 17090635 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17090635 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9736816 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9736816 — Surrogate Endpoint (SUR): Blood pressure
Study 28963124 — Predictive Biomarker (PRD): SLC7A5 mRNA
Genes: SLC7A5; CD98LC; LAT1; MPE16
Study 28963124 — Predictive Biomarker (PRD): SLC36A1 mRNA
Genes: SLC36A1; PAT1
Study 28963124 — Predictive Biomarker (PRD): SLC38A2 mRNA
Genes: SLC38A2; ATA2; KIAA1382; SAT2; SNAT2
Study 22664478 — Predictive Biomarker (PRD): LDHA mRNA
Genes: LDHA; PIG19
Study 22664478 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 22664478 — Predictive Biomarker (PRD): FLT1 mRNA
Genes: FLT1; FLT; FRT; VEGFR1
Study 22664478 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 22664478 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 22664478 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 22664478 — Predictive Biomarker (PRD): Hypoxia-inducible factor 1-alpha
Genes: HIF1A; BHLHE78; MOP1; PASD8
Study 19337169 — Surrogate Endpoint (SUR): Bone mineral density
Study 3020692 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAV1 mRNA
Genes: CAV1; CAV
Study 11752037 — Surrogate Endpoint (SUR): Serum potassium
Study 7487504 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 30621764 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17899047 — Surrogate Endpoint (SUR): Blood pressure
Study 30936633 — Surrogate Endpoint (SUR): Blood pressure
Study 2882082 — Surrogate Endpoint (SUR): Blood pressure
Study 31464558 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 21394895 — Predictive Biomarker (PRD): HRG mRNA
Genes: HRG
Study 10356669 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 2696505 — Surrogate Endpoint (SUR): Blood pressure
Study 31912605 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 25664779 — Surrogate Endpoint (SUR): Blood pressure
Study 23771193 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 22384546 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 11729034 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 2203486 — Surrogate Endpoint (SUR): Blood pressure
Study 30975923 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 30975923 — Predictive Biomarker (PRD): ERBB3 mRNA
Genes: ERBB3; HER3
Study 30975923 — Predictive Biomarker (PRD): HRG mRNA
Genes: HRG
Study 28118028 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30851879 — Surrogate Endpoint (SUR): Blood pressure
Study 17277040 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17277040 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10423639 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3297467 — Surrogate Endpoint (SUR): Blood pressure
Study 3297467 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18467730 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 8620278 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8620278 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30115263 — Surrogate Endpoint (SUR): Blood pressure
Study 17548728 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17548728 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17548728 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11246058 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11246058 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 11246058 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 23333095 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 23333095 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 20687956 — Surrogate Endpoint (SUR): Blood pressure
Study 18771406 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 18771406 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15048595 — Monitoring Biomarker (MOI): HBV DNA
Study 10728943 — Surrogate Endpoint (SUR): Blood pressure
Study 8807096 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 1381611 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 1381611 — Surrogate Endpoint (SUR): Blood pressure
Study 6208185 — Surrogate Endpoint (SUR): Blood pressure
Study 31271885 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27798510 — Surrogate Endpoint (SUR): Bone mineral density
Study 19528902 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17505157 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 17505157 — Surrogate Endpoint (SUR): Blood pressure
Study 24838894 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 24838894 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20649614 — Predictive Biomarker (PRD): PHEX mRNA
Genes: PHEX; PEX
Study 9927366 — Surrogate Endpoint (SUR): Blood pressure
Study 6781156 — Surrogate Endpoint (SUR): Blood pressure
Study 31583977 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 29480916 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 23168372 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23168372 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 23168372 — Surrogate Endpoint (SUR): Blood pressure
Study 1623908 — Surrogate Endpoint (SUR): Blood pressure
Study 27869358 — Surrogate Endpoint (SUR): Bone mineral density
Study 23434617 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23434617 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 23434617 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 23434617 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 16970087 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7956632 — Safety Biomarker (SAF): HLA-DQB1
Genes: IDDM1; CELIAC1
Study 30805607 — Surrogate Endpoint (SUR): Blood pressure
Study 19390517 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 19390517 — Surrogate Endpoint (SUR): Blood pressure
Study 19390517 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15282264 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 15282264 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 15282264 — Predictive Biomarker (PRD): CYP3A7 mRNA
Genes: CYP3A7
Study 22108915 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 22108915 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 22108915 — Predictive Biomarker (PRD): IGFBP1 mRNA
Genes: IGFBP1; IBP1
Study 22108915 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15704203 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 9813557 — Surrogate Endpoint (SUR): Blood pressure
Study 21271174 — Surrogate Endpoint (SUR): Blood pressure
Study 9671875 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 15085466 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 15085466 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 9773835 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 7840913 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29465203 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 29930098 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 29930098 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 22126423 — Surrogate Endpoint (SUR): Bone mineral density
Study 9653596 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 9653596 — Surrogate Endpoint (SUR): Blood pressure
Study 26239241 — Surrogate Endpoint (SUR): Blood pressure
Study 23902614 — Surrogate Endpoint (SUR): Blood pressure
Study 14627846 — Safety Biomarker (SAF): DRD2
Study 7282603 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7282603 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28526947 — Predictive Biomarker (PRD): TCN2 mRNA
Genes: TCN2; TC2
Study 28526947 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 24122767 — Predictive Biomarker (PRD): TNFRSF10B mRNA
Genes: TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; UNQ160/PRO186
Study 11995034 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 2202093 — Surrogate Endpoint (SUR): Blood pressure
Study 30461557 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 29515001 — Surrogate Endpoint (SUR): Blood pressure
Study 12032162 — Predictive Biomarker (PRD): MGP mRNA
Genes: MGP; MGLAP; GIG36
Study 25711322 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23372725 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 17349088 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17349088 — Surrogate Endpoint (SUR): Blood pressure
Study 8359080 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 1399944 — Surrogate Endpoint (SUR): Blood pressure
Study 16797393 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 10966908 — Surrogate Endpoint (SUR): Bone mineral density
Study 25033582 — Predictive Biomarker (PRD): DCT mRNA
Genes: DCT; TYRP2
Study 12515739 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 25726428 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19907160 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 19907160 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 19907160 — Surrogate Endpoint (SUR): Blood pressure
Study 9139276 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 1931065 — Surrogate Endpoint (SUR): Blood pressure
Study 6849167 — Surrogate Endpoint (SUR): Blood pressure
Study 23327033 — Surrogate Endpoint (SUR): Blood pressure
Study 20350344 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8866910 — Surrogate Endpoint (SUR): Blood pressure
Study 28340570 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 28340570 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 28340570 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17237648 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17237648 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17237648 — Surrogate Endpoint (SUR): Blood pressure
Study 18398800 — Surrogate Endpoint (SUR): Blood pressure
Study 9773111 — Surrogate Endpoint (SUR): Blood pressure
Study 20660038 — Predictive Biomarker (PRD): SERPINA6 mRNA
Genes: SERPINA6; CBG
Study 9972770 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 31375659 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31375659 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 31375659 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31375659 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 31375659 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 31375659 — Safety Biomarker (SAF): IL-6 and IL-10
Study 19415745 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 19415745 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 19415745 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19415745 — Predictive Biomarker (PRD): PGR mRNA
Genes: PGR; NR3C3
Study 10921016 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 31046941 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11282168 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 11282168 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11282168 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11282168 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 11282168 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 11282168 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 9290271 — Surrogate Endpoint (SUR): Blood pressure
Study 26975954 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21903984 — Surrogate Endpoint (SUR): Total kidney volume
Study 15135713 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10450715 — Surrogate Endpoint (SUR): Blood pressure
Study 8524699 — Surrogate Endpoint (SUR): Blood pressure
Study 487688 — Surrogate Endpoint (SUR): Blood pressure
Study 30924169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30924169 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 21362276 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21362276 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 31646806 — Predictive Biomarker (PRD): WAP four-disulfide core domain protein 2
Genes: WFDC2; HE4; WAP5
Study 31646806 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 31646806 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31646806 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 24573385 — Predictive Biomarker (PRD): FLT3 mRNA
Genes: FLT3; CD135; FLK2; STK1
Study 6760678 — Surrogate Endpoint (SUR): Blood pressure
Study 24335363 — Predictive Biomarker (PRD): TAOK2 mRNA
Genes: TAOK2; KIAA0881; MAP3K17; PSK; PSK1; UNQ2971/PRO7431
Study 15131767 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 9007706 — Monitoring Biomarker (MOI): HBV DNA
Study 18367653 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 18367653 — Surrogate Endpoint (SUR): Blood pressure
Study 18367653 — Surrogate Endpoint (SUR): Serum sodium
Study 15776134 — Safety Biomarker (SAF): Thiopurine S-methyltransferase
Genes: TPMT
Study 10965832 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10965832 — Safety Biomarker (SAF): IL-6 and IL-10
Study 11172448 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31283605 — Predictive Biomarker (PRD): Glutamate carboxypeptidase II
Genes: FOLH1; FOLH; NAALAD1; PSM; PSMA; GIG27
Study 17608155 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 8552268 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8552268 — Surrogate Endpoint (SUR): Blood pressure
Study 8552268 — Surrogate Endpoint (SUR): Serum creatinine
Study 8552268 — Surrogate Endpoint (SUR): Serum potassium
Study 30702630 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30702630 — Surrogate Endpoint (SUR): Blood pressure
Study 30702630 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 8896139 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6350313 — Surrogate Endpoint (SUR): Serum creatinine
Study 30153111 — Predictive Biomarker (PRD): ADRB1 mRNA
Genes: ADRB1; ADRB1R; B1AR
Study 30153111 — Predictive Biomarker (PRD): ADRB2 mRNA
Genes: ADRB2; ADRB2R; B2AR
Study 30153111 — Predictive Biomarker (PRD): ADRB3 mRNA
Genes: ADRB3; ADRB3R; B3AR
Study 27291249 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 22271410 — Predictive Biomarker (PRD): ADAM17 mRNA
Genes: ADAM17; CSVP; TACE
Study 9663357 — Surrogate Endpoint (SUR): Blood pressure
Study 30707877 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 29437943 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 24212915 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17545700 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 3190418 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 3190418 — Surrogate Endpoint (SUR): Blood pressure
Study 9773140 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 9773140 — Surrogate Endpoint (SUR): Blood pressure
Study 31225673 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 31225673 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31225673 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31225673 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19687349 — Predictive Biomarker (PRD): ABCG1 mRNA
Genes: ABCG1; ABC8; WHT1
Study 26545141 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26545141 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 19631515 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 19631515 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21892676 — Surrogate Endpoint (SUR): Bone mineral density
Study 26725133 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MHC class I polypeptide-related sequence A
Genes: MICA; PERB11.1
Study 24156441 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 14521724 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 14521724 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 14521724 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 6727693 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6727693 — Surrogate Endpoint (SUR): Serum triglycerides
Study 31128325 — Predictive Biomarker (PRD): CR1 mRNA
Genes: CR1; C3BR
Study 30054636 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30054636 — Predictive Biomarker (PRD): Hormone receptor
Study 25145426 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 20538020 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 10214534 — Surrogate Endpoint (SUR): Blood pressure
Study 24899755 — Predictive Biomarker (PRD): FXYD1 mRNA
Genes: FXYD1; PLM
Study 21976367 — Surrogate Endpoint (SUR): Bone mineral density
Study 20176737 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 20176737 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 20176737 — Surrogate Endpoint (SUR): Blood pressure
Study 31815705 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 428086 — Predictive Biomarker (PRD): DBH mRNA
Genes: DBH
Study 31604115 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 31604115 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 24821476 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 20524934 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 20524934 — Predictive Biomarker (PRD): IRAK1 mRNA
Genes: IRAK1; IRAK
Study 20524934 — Predictive Biomarker (PRD): TRAF6 mRNA
Genes: TRAF6; RNF85
Study 20524934 — Safety Biomarker (SAF): miR-146a
Genes: MIR146A
Study 15669892 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 12691536 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10496186 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9150968 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 9150968 — Surrogate Endpoint (SUR): Blood pressure
Study 25769593 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 23282124 — Surrogate Endpoint (SUR): Blood pressure
Study 15633319 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 9159367 — Predictive Biomarker (PRD): MTR mRNA
Genes: MTR
Study 2446077 — Surrogate Endpoint (SUR): Blood pressure
Study 23911205 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21514808 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9269786 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 20048389 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1