TrialPanorama/TrialPanorama-database huggingface dataset:
Study 11881131 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11881131 — Surrogate Endpoint (SUR): Blood pressure
Study 9663917 — Surrogate Endpoint (SUR): Blood pressure
Study 8385179 — Surrogate Endpoint (SUR): Blood pressure
Study 29342506 — Surrogate Endpoint (SUR): Serum uric acid
Study 29342506 — Surrogate Endpoint (SUR): Blood pressure
Study 28554530 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 26424212 — Surrogate Endpoint (SUR): Serum uric acid
Study 21547496 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 15964100 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 8091754 — Safety Biomarker (SAF): Preexisting antibody
Study 16520410 — Surrogate Endpoint (SUR): Blood pressure
Study 16520410 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 31524681 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 6380858 — Surrogate Endpoint (SUR): Blood pressure
Study 3524185 — Surrogate Endpoint (SUR): Serum potassium
Study 1925430 — Surrogate Endpoint (SUR): Blood pressure
Study 30924895 — Predictive Biomarker (PRD): PRKRA mRNA
Genes: PRKRA; PACT; RAX; HSD-14; HSD14
Study 28957643 — Surrogate Endpoint (SUR): Forced vital capacity
Study 25810425 — Surrogate Endpoint (SUR): Forced vital capacity
Study 22472154 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20353029 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 9231815 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 9231815 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22722891 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22722891 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17085655 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 17085655 — Predictive Biomarker (PRD): Carbonic anhydrase IX
Genes: CA9; G250; MN
Study 17085655 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 23325917 — Surrogate Endpoint (SUR): Blood pressure
Study 17950093 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 17950093 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17950093 — Surrogate Endpoint (SUR): Blood pressure
Study 17950093 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9456255 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9456255 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28391912 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 28391912 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 28391912 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 28391912 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 28391912 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28391912 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 28391912 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21719555 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 17711731 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30646948 — Surrogate Endpoint (SUR): Blood pressure
Study 30646948 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22001391 — Predictive Biomarker (PRD): RASGRP1 mRNA
Genes: RASGRP1; RASGRP
Study 11891813 — Predictive Biomarker (PRD): IL1RN mRNA
Genes: IL1RN; IL1F3; IL1RA
Study 11891813 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11891813 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 11891813 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9527081 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27629750 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 21042231 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 19296144 — Surrogate Endpoint (SUR): Bone mineral density
Study 3097668 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 14698357 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7934684 — Surrogate Endpoint (SUR): Blood pressure
Study 9157942 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 31578132 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 18395728 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18395728 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1657611 — Surrogate Endpoint (SUR): Serum testosterone
Study 22723322 — Surrogate Endpoint (SUR): Bone mineral density
Study 17368339 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 17825687 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 17825687 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17825687 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16210253 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 16210253 — Surrogate Endpoint (SUR): Blood pressure
Study 10482999 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 10482999 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 10482999 — Predictive Biomarker (PRD): CD22 mRNA
Genes: CD22; SIGLEC2
Study 9519950 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9339405 — Surrogate Endpoint (SUR): Blood pressure
Study 9339405 — Surrogate Endpoint (SUR): Serum sodium
Study 2875321 — Surrogate Endpoint (SUR): Blood pressure
Study 18503600 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24890683 — Surrogate Endpoint (SUR): Blood pressure
Study 17122092 — Predictive Biomarker (PRD): MZB1 mRNA
Genes: MZB1; MEDA7; PACAP; HSPC190
Study 10447050 — Surrogate Endpoint (SUR): Blood pressure
Study 30287669 — Predictive Biomarker (PRD): FHL5 mRNA
Genes: FHL5; ACT
Study 16249890 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 10762507 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 6373094 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 29624362 — Surrogate Endpoint (SUR): Blood pressure
Study 12091327 — Monitoring Biomarker (MOI): HBV DNA
Study 25704750 — Predictive Biomarker (PRD): JAK3 mRNA
Genes: JAK3
Study 25704750 — Predictive Biomarker (PRD): JAK1 mRNA
Genes: JAK1; JAK1A; JAK1B
Study 25704750 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 10391813 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 22765260 — Predictive Biomarker (PRD): CFP mRNA
Genes: CFP; PFC
Study 18500678 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 8584609 — Surrogate Endpoint (SUR): Blood pressure
Study 31881545 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31881545 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 31733754 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 28515105 — Predictive Biomarker (PRD): SHOX2 mRNA
Genes: SHOX2; OG12X; SHOT
Study 28515105 — Monitoring Biomarker (MOI): Cell-free DNA
Study 21740564 — Surrogate Endpoint (SUR): Blood pressure
Study 17011781 — Surrogate Endpoint (SUR): Bone mineral density
Study 30077569 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 26722854 — Predictive Biomarker (PRD): GFAP mRNA
Genes: GFAP
Study 26722854 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26722854 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7032273 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24196948 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 12953084 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 12175403 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 9657539 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27231835 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 25138736 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25138736 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25138736 — Surrogate Endpoint (SUR): Serum triglycerides
Study 16847150 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12878372 — Surrogate Endpoint (SUR): Blood pressure
Study 10689518 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 10689518 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 7704933 — Safety Biomarker (SAF): Interleukin 1
Study 31585740 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 23183529 — Predictive Biomarker (PRD): BOC mRNA
Genes: BOC; UNQ604/PRO1190
Study 23183529 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 21803011 — Predictive Biomarker (PRD): CNR1 mRNA
Genes: CNR1; CNR
Study 21803011 — Pharmacodynamic Biomarker (PDY): Fatty acid amide hydrolase 1
Genes: FAAH; FAAH1
Study 21803011 — Predictive Biomarker (PRD): MGLL mRNA
Genes: MGLL
Study 22288906 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 18756741 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18756741 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18756741 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 8729092 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 3956107 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 21090563 — Predictive Biomarker (PRD): ACAD8 mRNA
Genes: ACAD8; ARC42; IBD
Study 10224206 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6430666 — Surrogate Endpoint (SUR): Blood pressure
Study 30500183 — Predictive Biomarker (PRD): SSB mRNA
Genes: SSB
Study 30500183 — Predictive Biomarker (PRD): FANCM mRNA
Genes: FANCM; KIAA1596
Study 28918212 — Surrogate Endpoint (SUR): Blood pressure
Study 24646172 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20556536 — Surrogate Endpoint (SUR): Blood pressure
Study 12173197 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 21771179 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 9844097 — Surrogate Endpoint (SUR): Bone mineral density
Study 23815562 — Surrogate Endpoint (SUR): Blood pressure
Study 27168572 — Surrogate Endpoint (SUR): Bone mineral density
Study 25023055 — Monitoring Biomarker (MOI): HBV DNA
Study 22613532 — Surrogate Endpoint (SUR): Serum creatinine
Study 18224311 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 8025966 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 31914556 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 31914556 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31914556 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23571719 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9407640 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 9407640 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 28112467 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 24602091 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15243303 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15243303 — Surrogate Endpoint (SUR): Blood pressure
Study 14602747 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10951436 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 8797398 — Surrogate Endpoint (SUR): Serum potassium
Study 6706302 — Surrogate Endpoint (SUR): Plasma ammonia
Study 22445475 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 1898434 — Surrogate Endpoint (SUR): Blood pressure
Study 31776726 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 31531572 — Surrogate Endpoint (SUR): Blood pressure
Study 3537019 — Surrogate Endpoint (SUR): Probing pocket depth
Study 23628502 — Surrogate Endpoint (SUR): Blood pressure
Study 17163239 — Surrogate Endpoint (SUR): Blood pressure
Study 17163239 — Surrogate Endpoint (SUR): Serum potassium
Study 9106905 — Surrogate Endpoint (SUR): Blood pressure
Study 21911655 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 9086315 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9086315 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 9086315 — Surrogate Endpoint (SUR): Blood pressure
Study 23937688 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 17295714 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 9207281 — Surrogate Endpoint (SUR): Bone mineral density
Study 12819249 — Surrogate Endpoint (SUR): Serum creatinine
Study 12819249 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 12819249 — Surrogate Endpoint (SUR): Serum triglycerides
Study 8194433 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 8194433 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8194433 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11440284 — Surrogate Endpoint (SUR): Blood pressure
Study 3076136 — Surrogate Endpoint (SUR): Blood pressure
Study 16912024 — Surrogate Endpoint (SUR): Blood pressure
Study 14685864 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 23500091 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 11550733 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11550733 — Safety Biomarker (SAF): Interleukin 1
Study 3293400 — Surrogate Endpoint (SUR): Blood pressure
Study 27718000 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 27718000 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 22466026 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 9657471 — Predictive Biomarker (PRD): ITGB2 mRNA
Genes: ITGB2; CD18; MFI7
Study 9657471 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10829905 — Surrogate Endpoint (SUR): Serum calcium
Study 21409399 — Surrogate Endpoint (SUR): Blood pressure
Study 18620827 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 11375295 — Surrogate Endpoint (SUR): Bone mineral density
Study 1760535 — Surrogate Endpoint (SUR): Blood pressure
Study 7046411 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 28450529 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28450529 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 28450529 — Monitoring Biomarker (MOI): Angiopoietin-1
Genes: ANGPT1; KIAA0003
Study 28450529 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23425517 — Surrogate Endpoint (SUR): Blood pressure
Study 10573242 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 3987929 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 31912903 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 12588325 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 12588325 — Surrogate Endpoint (SUR): Serum creatinine
Study 8247917 — Surrogate Endpoint (SUR): Blood pressure
Study 17468862 — Predictive Biomarker (PRD): ABCC2 mRNA
Genes: ABCC2; CMOAT; CMOAT1; CMRP; MRP2
Study 23526939 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 23526939 — Surrogate Endpoint (SUR): Serum creatinine
Study 2050833 — Surrogate Endpoint (SUR): Blood pressure
Study 26778138 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11293751 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 17989918 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15175633 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15175633 — Surrogate Endpoint (SUR): Blood pressure
Study 9719049 — Surrogate Endpoint (SUR): Blood pressure
Study 7654109 — Surrogate Endpoint (SUR): Blood pressure
Study 31920107 — Surrogate Endpoint (SUR): Blood pressure
Study 31002638 — Surrogate Endpoint (SUR): Blood pressure
Study 31002638 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31002638 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19456003 — Surrogate Endpoint (SUR): Blood pressure
Study 9160197 — Predictive Biomarker (PRD): CTLA4
Genes: CD152; CD; GSE; CTLA-4
Study 8125425 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8125425 — Surrogate Endpoint (SUR): Serum sodium
Study 31545914 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31545914 — Safety Biomarker (SAF): Reactive oxygen species
Study 26881934 — Surrogate Endpoint (SUR): Blood pressure
Study 18490931 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15986036 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 15986036 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 9988393 — Safety Biomarker (SAF): Reactive oxygen species
Study 7574193 — Surrogate Endpoint (SUR): Blood pressure
Study 1689417 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31161927 — Predictive Biomarker (PRD): MMRN1 mRNA
Genes: MMRN1; ECM; EMILIN4; GPIA*; MMRN
Study 28550195 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 26081815 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6367533 — Surrogate Endpoint (SUR): Blood pressure
Study 7541064 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29901635 — Predictive Biomarker (PRD): SQSTM1 mRNA
Genes: SQSTM1; ORCA; OSIL
Study 29901635 — Predictive Biomarker (PRD): TARDBP mRNA
Genes: TARDBP; TDP43
Study 24793669 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 31492016 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 27040515 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 17503747 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7472824 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 31826009 — Predictive Biomarker (PRD): GSR mRNA
Genes: GSR; GLUR; GRD1
Study 28323139 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28323139 — Monitoring Biomarker (MOI): Urokinase plasminogen activator surface receptor
Genes: PLAUR; MO3; UPAR
Study 28323139 — Safety Biomarker (SAF): IL-6 and IL-10
Study 7926910 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 17006746 — Surrogate Endpoint (SUR): Blood pressure
Study 10702171 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26081662 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 26081662 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 18598160 — Surrogate Endpoint (SUR): Serum potassium
Study 19657788 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19657788 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9972338 — Surrogate Endpoint (SUR): Blood pressure
Study 3149455 — Surrogate Endpoint (SUR): Serum testosterone
Study 29338146 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 29338146 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29338146 — Safety Biomarker (SAF): Hyaluronic acid
Study 16970093 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16970093 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16970093 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27364603 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 24731917 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12817518 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 12817518 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 12817518 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 10937516 — Surrogate Endpoint (SUR): Serum creatinine
Study 7522529 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 23736797 — Monitoring Biomarker (MOI): HBV DNA
Study 8299884 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8299884 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18834823 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 8045488 — Monitoring Biomarker (MOI): HBV DNA
Study 31189686 — Predictive Biomarker (PRD): SRM mRNA
Genes: SRM; SPS1; SRML1