TrialPanorama/TrialPanorama-database huggingface dataset:
Study 11350400 — Predictive Biomarker (PRD): P2RX6 mRNA
Genes: P2RX6; P2RXL1; P2X6
Study 28921839 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 19717156 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18400702 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 31935118 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31935118 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31935118 — Safety Biomarker (SAF): IL-6 and IL-10
Study 16891570 — Predictive Biomarker (PRD): HPSE mRNA
Genes: HPSE; HEP; HPA; HPA1; HPR1; HPSE1; HSE1
Study 9856370 — Surrogate Endpoint (SUR): Blood pressure
Study 23776118 — Predictive Biomarker (PRD): ARC mRNA
Genes: ARC; KIAA0278
Study 10534145 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6983207 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 6983207 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 6983207 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 26999688 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 26999688 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25128278 — Surrogate Endpoint (SUR): Probing pocket depth
Study 18711762 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30224383 — Pharmacodynamic Biomarker (PDY): Beta-secretase 1
Genes: BACE1; BACE; KIAA1149
Study 30224383 — Pharmacodynamic Biomarker (PDY): Amyloid beta peptide (1-40)
Genes: APP; A4; AD1
Study 21223653 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 331137 — Surrogate Endpoint (SUR): Blood pressure
Study 30587857 — Surrogate Endpoint (SUR): Blood pressure
Study 17033909 — Predictive Biomarker (PRD): FANCE mRNA
Genes: FANCE; FACE
Study 11999665 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11999665 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 27473843 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 28641369 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28641369 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 16173527 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29915123 — Predictive Biomarker (PRD): ABCD2 mRNA
Genes: ABCD2; ALD1; ALDL1; ALDR; ALDRP
Study 25083241 — Surrogate Endpoint (SUR): Blood pressure
Study 10468065 — Surrogate Endpoint (SUR): Blood pressure
Study 1282585 — Surrogate Endpoint (SUR): Blood pressure
Study 22921641 — Surrogate Endpoint (SUR): Blood pressure
Study 18585494 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7609511 — Surrogate Endpoint (SUR): Blood pressure
Study 2884879 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 2884879 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 26947331 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 26947331 — Predictive Biomarker (PRD): CDK4 mRNA
Genes: CDK4
Study 26947331 — Predictive Biomarker (PRD): CDK6 mRNA
Genes: CDK6; CDKN6
Study 26947331 — Predictive Biomarker (PRD): PIK3CA mRNA
Genes: PIK3CA
Study 26947331 — Predictive Biomarker (PRD): Hormone receptor
Study 25194408 — Surrogate Endpoint (SUR): Serum uric acid
Study 25194408 — Surrogate Endpoint (SUR): Serum creatinine
Study 8610379 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 8240460 — Safety Biomarker (SAF): BCHE
Genes: E1
Study 24434128 — Surrogate Endpoint (SUR): Blood pressure
Study 2167727 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 381955 — Surrogate Endpoint (SUR): Serum uric acid
Study 381955 — Surrogate Endpoint (SUR): Serum creatinine
Study 21964530 — Predictive Biomarker (PRD): LOX mRNA
Genes: LOX
Study 21964530 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21964530 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 26644265 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26644265 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 26644265 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26644265 — Predictive Biomarker (PRD): IL7 mRNA
Genes: IL7
Study 18476293 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16571140 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 1308919 — Surrogate Endpoint (SUR): Bone mineral density
Study 31411985 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 26392403 — Predictive Biomarker (PRD): MCC mRNA
Genes: MCC
Study 12402450 — Surrogate Endpoint (SUR): Blood pressure
Study 10465182 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 373393 — Surrogate Endpoint (SUR): Serum potassium
Study 31042551 — Predictive Biomarker (PRD): ADRB1 mRNA
Genes: ADRB1; ADRB1R; B1AR
Study 23535872 — Predictive Biomarker (PRD): PGD mRNA
Genes: PGD; PGDH
Study 9776437 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 9776437 — Surrogate Endpoint (SUR): Blood pressure
Study 20128295 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18200775 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 14741066 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14741066 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 3029258 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 3029258 — Surrogate Endpoint (SUR): Blood pressure
Study 29720328 — Surrogate Endpoint (SUR): Bacterial count
Study 9147856 — Surrogate Endpoint (SUR): Serum creatinine
Study 1491771 — Surrogate Endpoint (SUR): Blood pressure
Study 1491771 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 22520669 — Surrogate Endpoint (SUR): Blood pressure
Study 22520669 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20479407 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 18752330 — Monitoring Biomarker (MOI): HBV DNA
Study 10926637 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 26721653 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22385885 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22385885 — Surrogate Endpoint (SUR): Blood pressure
Study 11035668 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 2580176 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30203681 — Predictive Biomarker (PRD): ENG mRNA
Genes: ENG; END
Study 23327035 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23327035 — Surrogate Endpoint (SUR): Blood pressure
Study 20573787 — Predictive Biomarker (PRD): SELENOP mRNA
Genes: SELENOP; SELP; SEPP1
Study 18043579 — Predictive Biomarker (PRD): TOX mRNA
Genes: TOX; KIAA0808
Study 18043579 — Predictive Biomarker (PRD): REL mRNA
Genes: REL
Study 21993365 — Surrogate Endpoint (SUR): Blood pressure
Study 18408049 — Surrogate Endpoint (SUR): Forced vital capacity
Study 14559315 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 14559315 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 24941841 — Predictive Biomarker (PRD): PCSK5 mRNA
Genes: PCSK5; PC5; PC6
Study 24941841 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24941841 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16155276 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 12514575 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 8877824 — Surrogate Endpoint (SUR): Blood pressure
Study 1889971 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 1889971 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 27488365 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 25151492 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 25151492 — Surrogate Endpoint (SUR): Blood pressure
Study 25261549 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): VGF mRNA
Genes: VGF
Study 16202151 — Surrogate Endpoint (SUR): Blood pressure
Study 12188390 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31522845 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 17578313 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17578313 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9713009 — Surrogate Endpoint (SUR): Forced vital capacity
Study 21342757 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 12730793 — Surrogate Endpoint (SUR): Bone mineral density
Study 31764461 — Surrogate Endpoint (SUR): Blood pressure
Study 30998396 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 8672382 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26478104 — Safety Biomarker (SAF): Hyaluronic acid
Study 24944137 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24944137 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 18400976 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 14640387 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8648205 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 1465689 — Surrogate Endpoint (SUR): Blood pressure
Study 25439691 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 25439691 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 1910800 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28157726 — Predictive Biomarker (PRD): ABAT mRNA
Genes: ABAT; GABAT
Study 28157726 — Predictive Biomarker (PRD): CNDP2 mRNA
Genes: CNDP2; CN2; CPGL; HEL-S-13; PEPA
Study 28157726 — Predictive Biomarker (PRD): SLC15A2 mRNA
Genes: SLC15A2; PEPT2
Study 28157726 — Predictive Biomarker (PRD): SLC36A1 mRNA
Genes: SLC36A1; PAT1
Study 24083670 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 23630033 — Predictive Biomarker (PRD): SLC5A1 mRNA
Genes: SLC5A1; NAGT; SGLT1
Study 23630033 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 23630033 — Surrogate Endpoint (SUR): Blood pressure
Study 20126853 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 18046974 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18046974 — Surrogate Endpoint (SUR): Blood pressure
Study 2168123 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 31314952 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 31314952 — Predictive Biomarker (PRD): ASIC3 mRNA
Genes: ASIC3; ACCN3; SLNAC1; TNAC1
Study 31314952 — Predictive Biomarker (PRD): TRPV1 mRNA
Genes: TRPV1; VR1
Study 10807760 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 28947180 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 18371557 — Surrogate Endpoint (SUR): Serum creatinine
Study 16368472 — Surrogate Endpoint (SUR): Bone mineral density
Study 12830471 — Surrogate Endpoint (SUR): Serum creatinine
Study 8998818 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 26998845 — Predictive Biomarker (PRD): IDS mRNA
Genes: IDS; SIDS
Study 26998845 — Predictive Biomarker (PRD): PTGDS mRNA
Genes: PTGDS; PDS
Study 24363029 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16756652 — Surrogate Endpoint (SUR): Blood pressure
Study 29642136 — Predictive Biomarker (PRD): IDE mRNA
Genes: IDE
Study 25326927 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22269152 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 22269152 — Surrogate Endpoint (SUR): Serum creatinine
Study 20303247 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 17710485 — Predictive Biomarker (PRD): PPP1R13L mRNA
Genes: PPP1R13L; IASPP; NKIP1; PPP1R13BL; RAI
Study 15837772 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 31768768 — Surrogate Endpoint (SUR): Bone mineral density
Study 27383196 — Safety Biomarker (SAF): miR-192
Genes: MIR192
Study 27383196 — Safety Biomarker (SAF): miR-375
Genes: MIR375
Study 27383196 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-21
Genes: MIR21
Study 11319199 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2894246 — Surrogate Endpoint (SUR): Blood pressure
Study 22444829 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 11040249 — Surrogate Endpoint (SUR): Blood pressure
Study 23129601 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23129601 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23129601 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23129601 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20704110 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 20704110 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 16236035 — Surrogate Endpoint (SUR): Blood pressure
Study 12440353 — Surrogate Endpoint (SUR): Blood pressure
Study 7582879 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 26493248 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 24066730 — Surrogate Endpoint (SUR): Blood pressure
Study 17234519 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 15200998 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7849542 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 7849542 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 29459408 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 26251078 — Predictive Biomarker (PRD): ABO mRNA
Genes: ABO
Study 20864423 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 20864423 — Safety Biomarker (SAF): IL-6 and IL-10
Study 9707356 — Surrogate Endpoint (SUR): Blood pressure
Study 7536138 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7536138 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 2650539 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2650539 — Surrogate Endpoint (SUR): Serum creatinine
Study 31102328 — Predictive Biomarker (PRD): NTM mRNA
Genes: NTM; IGLON2; NT; UNQ297/PRO337
Study 19153678 — Surrogate Endpoint (SUR): Bone mineral density
Study 16353616 — Surrogate Endpoint (SUR): Blood pressure
Study 16353616 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 16353616 — Surrogate Endpoint (SUR): Serum triglycerides
Study 25763853 — Safety Biomarker (SAF): Hyaluronic acid
Study 23804543 — Predictive Biomarker (PRD): TNFSF14 mRNA
Genes: TNFSF14; HVEML; LIGHT; UNQ391/PRO726
Study 9092145 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26969090 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26969090 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20485880 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10522523 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 25912752 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 21355070 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 21355070 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 21355070 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 21355070 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 10930961 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 10930961 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 8339808 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 28234719 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 7977523 — Surrogate Endpoint (SUR): Bone mineral density
Study 29141361 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29141361 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 29141361 — Surrogate Endpoint (SUR): Serum creatinine
Study 29141361 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 29141361 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 19845453 — Surrogate Endpoint (SUR): Blood pressure
Study 17148774 — Predictive Biomarker (PRD): CDKN1B mRNA
Genes: CDKN1B; KIP1; p27
Study 12962749 — Surrogate Endpoint (SUR): Serum creatinine
Study 7732997 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1682228 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10841922 — Safety Biomarker (SAF): Reactive oxygen species
Study 31411039 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 9797622 — Surrogate Endpoint (SUR): Blood pressure
Study 21806387 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 21806387 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 21806387 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 8466026 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 2879477 — Surrogate Endpoint (SUR): Blood pressure
Study 29331635 — Predictive Biomarker (PRD): Chromosome 5q
Study 18774000 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18774000 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 22841694 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16043801 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 26819451 — Predictive Biomarker (PRD): ITPKB mRNA
Genes: ITPKB
Study 26819451 — Predictive Biomarker (PRD): MFHAS1 mRNA
Genes: MFHAS1; MASL1
Study 26819451 — Predictive Biomarker (PRD): TNFAIP3 mRNA
Genes: TNFAIP3; OTUD7C
Study 26819451 — Predictive Biomarker (PRD): GNA13 mRNA
Genes: GNA13
Study 15481766 — Surrogate Endpoint (SUR): Blood pressure
Study 16966110 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 22048466 — Predictive Biomarker (PRD): CHRNB2 mRNA
Genes: CHRNB2
Study 22048466 — Predictive Biomarker (PRD): CHRNA5 mRNA
Genes: CHRNA5; NACHRA5
Study 22048466 — Predictive Biomarker (PRD): CHRNA4 mRNA
Genes: CHRNA4; NACRA4
Study 22048466 — Predictive Biomarker (PRD): CYP2B6 mRNA
Genes: CYP2B6
Study 1315825 — Surrogate Endpoint (SUR): Blood pressure
Study 15132405 — Surrogate Endpoint (SUR): Bone mineral density
Study 27768727 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 11925390 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 11925390 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 10521386 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 11464717 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 11464717 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11464717 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9727375 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9727375 — Safety Biomarker (SAF): ACE
Genes: ACE1; CD143
Study 7979809 — Surrogate Endpoint (SUR): Sperm parameters
Study 28703838 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 25226738 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 25226738 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20934312 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 16839800 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 12870136 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 21184653 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 21184653 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 19656025 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 11152843 — Surrogate Endpoint (SUR): Blood pressure
Study 31959233 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29358714 — Predictive Biomarker (PRD): ADAM10 mRNA
Genes: ADAM10; KUZ; MADM
Study 29358714 — Pharmacodynamic Biomarker (PDY): Amyloid beta peptide (1-40)
Genes: APP; A4; AD1
Study 24572041 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24572041 — Surrogate Endpoint (SUR): Blood pressure
Study 16864147 — Surrogate Endpoint (SUR): Blood pressure
Study 16864147 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11930704 — Surrogate Endpoint (SUR): Bone mineral density
Study 11930704 — Surrogate Endpoint (SUR): Serum calcium
Study 11930704 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 11930704 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 9773137 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9773137 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 9773137 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 30638420 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28351028 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 19729392 — Predictive Biomarker (PRD): MCIDAS mRNA
Genes: MCIDAS; IDAS; MCI; MCIN
Study 31524116 — Predictive Biomarker (PRD): FFAR4 mRNA
Genes: FFAR4; GPR120; GPR129; O3FAR1; PGR4
Study 27720403 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 21325298 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 21325298 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 21325298 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP