TrialPanorama/TrialPanorama-database huggingface dataset:
Study 12519412 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 28682439 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28682439 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25091596 — Surrogate Endpoint (SUR): Serum potassium
Study 21197586 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21197586 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 21197586 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18070658 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 14693168 — Predictive Biomarker (PRD): PTS mRNA
Genes: PTS
Study 10902643 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18665190 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11340333 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11340333 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 26652592 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 8444683 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 25463664 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 22999673 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17640058 — Predictive Biomarker (PRD): PTGS1 mRNA
Genes: PTGS1; COX1
Study 17640058 — Predictive Biomarker (PRD); Safety Biomarker (SAF): COX2 mRNA
Genes: PTGS2; COX2
Study 17640058 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 15649652 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2152973 — Surrogate Endpoint (SUR): Blood pressure
Study 2152973 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10604885 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 20017943 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 18074501 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15069173 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 15069173 — Surrogate Endpoint (SUR): Serum calcium
Study 15630469 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9222086 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 8490471 — Surrogate Endpoint (SUR): Blood pressure
Study 27989253 — Surrogate Endpoint (SUR): Blood pressure
Study 20502393 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21753062 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21753062 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31486230 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 31486230 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 9049555 — Surrogate Endpoint (SUR): Blood pressure
Study 25703450 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 24081236 — Predictive Biomarker (PRD): TFAP2B mRNA
Genes: TFAP2B
Study 10021955 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10021955 — Surrogate Endpoint (SUR): Blood pressure
Study 7826557 — Surrogate Endpoint (SUR): Blood pressure
Study 12070571 — Surrogate Endpoint (SUR): Blood pressure
Study 28818225 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 23485949 — Predictive Biomarker (PRD): HTR1B mRNA
Genes: HTR1B; HTR1DB
Study 23485949 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 23485949 — Predictive Biomarker (PRD): DRD4 mRNA
Genes: DRD4
Study 15105283 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28547998 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 23065731 — Predictive Biomarker (PRD): DEF6 mRNA
Genes: DEF6; IBP
Study 18398081 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 1633050 — Surrogate Endpoint (SUR): Blood pressure
Study 6329004 — Surrogate Endpoint (SUR): Blood pressure
Study 22770575 — Predictive Biomarker (PRD): BAK1 mRNA
Genes: BAK1; BAK; BCL2L7; CDN1
Study 17261962 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17261962 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22990062 — Surrogate Endpoint (SUR): Serum sodium
Study 11593871 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 8045971 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 1283188 — Surrogate Endpoint (SUR): Blood pressure
Study 25790846 — Predictive Biomarker (PRD): RITA1 mRNA
Genes: RITA1; C12orf52; RITA; PSEC0043
Study 12212667 — Surrogate Endpoint (SUR): Blood pressure
Study 7858555 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7858555 — Surrogate Endpoint (SUR): Blood pressure
Study 7198366 — Surrogate Endpoint (SUR): Blood pressure
Study 29557078 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29557078 — Surrogate Endpoint (SUR): Blood pressure
Study 10699107 — Surrogate Endpoint (SUR): Blood pressure
Study 8222190 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 25577300 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25577300 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24252844 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21325137 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 21325137 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21325137 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19363221 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 19363221 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 17531579 — Predictive Biomarker (PRD): AGTR1 mRNA
Genes: AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B
Study 17531579 — Surrogate Endpoint (SUR): Blood pressure
Study 17531579 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9458249 — Surrogate Endpoint (SUR): Blood pressure
Study 19962771 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 17959037 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 11329494 — Surrogate Endpoint (SUR): Blood pressure
Study 10186967 — Predictive Biomarker (PRD): PTGDS mRNA
Genes: PTGDS; PDS
Study 25622823 — Surrogate Endpoint (SUR): Blood pressure
Study 19958964 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19958964 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9248765 — Predictive Biomarker (PRD): Hormone receptor
Study 27317436 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 17126768 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17126768 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18174457 — Predictive Biomarker (PRD): ADAMTS1 mRNA
Genes: ADAMTS1; KIAA1346; METH1
Study 8447207 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 28389851 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 18691988 — Surrogate Endpoint (SUR): Blood pressure
Study 2189450 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23645374 — Predictive Biomarker (PRD): EBF1 mRNA
Genes: EBF1; COE1; EBF
Study 10642014 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 8444070 — Safety Biomarker (SAF): 51Cr-EDTA
Study 30497420 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19012813 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 1758244 — Surrogate Endpoint (SUR): Blood pressure
Study 21739685 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 12215608 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12215608 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 12215608 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 8610716 — Surrogate Endpoint (SUR): Forced vital capacity
Study 7080491 — Surrogate Endpoint (SUR): Blood pressure
Study 30401688 — Predictive Biomarker (PRD): FLT1 mRNA
Genes: FLT1; FLT; FRT; VEGFR1
Study 30401688 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 23876536 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 18001477 — Surrogate Endpoint (SUR): Serum creatinine
Study 2711990 — Surrogate Endpoint (SUR): Blood pressure
Study 28462683 — Surrogate Endpoint (SUR): Blood pressure
Study 27400005 — Surrogate Endpoint (SUR): Blood pressure
Study 19036172 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 11823085 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30772849 — Safety Biomarker (SAF): Interleukin 1
Study 19709060 — Surrogate Endpoint (SUR): Probing pocket depth
Study 11866419 — Surrogate Endpoint (SUR): Blood pressure
Study 29274540 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29274540 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 29274540 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 25052227 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27236813 — Surrogate Endpoint (SUR): Blood pressure
Study 10513351 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 27322609 — Predictive Biomarker (PRD): FHL5 mRNA
Genes: FHL5; ACT
Study 15136366 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15136366 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19783777 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19783777 — Surrogate Endpoint (SUR): Blood pressure
Study 3415805 — Surrogate Endpoint (SUR): Blood pressure
Study 17416006 — Predictive Biomarker (PRD): MCAT mRNA
Genes: MCAT; MT
Study 30008280 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30008280 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30008280 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 30008280 — Safety Biomarker (SAF): BDNF
Study 28338362 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23108482 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21418096 — Surrogate Endpoint (SUR): Blood pressure
Study 7828384 — Surrogate Endpoint (SUR): Blood pressure
Study 24872119 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15673854 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12923444 — Surrogate Endpoint (SUR): Bone mineral density
Study 21741739 — Predictive Biomarker (PRD): NTM mRNA
Genes: NTM; IGLON2; NT; UNQ297/PRO337
Study 28122892 — Predictive Biomarker (PRD): CD52 mRNA
Genes: CD52; CDW52; HE5
Study 17244173 — Surrogate Endpoint (SUR): Blood pressure
Study 15660234 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 15660234 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 15660234 — Safety Biomarker (SAF): Dihydrothymine dehydrogenase
Genes: DPYD
Study 12814035 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 18836845 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18836845 — Monitoring Biomarker (MOI): Procalcitonin
Study 17164307 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 581782 — Surrogate Endpoint (SUR): Blood pressure
Study 30765389 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 20593411 — Surrogate Endpoint (SUR): Bone mineral density
Study 28959907 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28959907 — Surrogate Endpoint (SUR): Probing pocket depth
Study 9579389 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31419622 — Surrogate Endpoint (SUR): Blood pressure
Study 23149074 — Surrogate Endpoint (SUR): Blood pressure
Study 24903387 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24903387 — Surrogate Endpoint (SUR): Serum creatinine
Study 15606381 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15606381 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 15606381 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15606381 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 28474968 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 26860024 — Surrogate Endpoint (SUR): Blood pressure
Study 15280524 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11202421 — Surrogate Endpoint (SUR): Blood pressure
Study 1602805 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 27150701 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 24958326 — Surrogate Endpoint (SUR): Blood pressure
Study 22930812 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9667346 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 28157835 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25736990 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 23179201 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 1414179 — Surrogate Endpoint (SUR): Blood pressure
Study 23103663 — Surrogate Endpoint (SUR): Serum creatinine
Study 2257861 — Predictive Biomarker (PRD): STC1 mRNA
Genes: STC1; STC
Study 7411244 — Safety Biomarker (SAF): Bacterial beta-glucuronidase
Genes: uidA; gurA; gusA; b1617; JW1609
Study 31288854 — Surrogate Endpoint (SUR): Blood pressure
Study 9327312 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9327312 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 3519107 — Surrogate Endpoint (SUR): Forced vital capacity
Study 29140155 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 8728351 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24733007 — Predictive Biomarker (PRD): CHRNA5 mRNA
Genes: CHRNA5; NACHRA5
Study 11910301 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8202904 — Surrogate Endpoint (SUR): Forced vital capacity
Study 28244205 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18653228 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 23275433 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16919531 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8105829 — Surrogate Endpoint (SUR): Blood pressure
Study 28850362 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 23280514 — Surrogate Endpoint (SUR): Blood pressure
Study 21585703 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 18326964 — Surrogate Endpoint (SUR): Blood pressure
Study 8623996 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8623996 — Surrogate Endpoint (SUR): Blood pressure
Study 6397330 — Surrogate Endpoint (SUR): Blood pressure
Study 25456755 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25456755 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25456755 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 30829962 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 21084649 — Surrogate Endpoint (SUR): Plasma phenylalanine
Study 22334768 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 17435976 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17435976 — Surrogate Endpoint (SUR): Blood pressure
Study 15385353 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 11238801 — Surrogate Endpoint (SUR): Blood pressure
Study 11238801 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 7639417 — Surrogate Endpoint (SUR): Blood pressure
Study 2502040 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 19385031 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 16912022 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27077672 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27077672 — Safety Biomarker (SAF): Interleukin 1
Study 27077672 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27077672 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27077672 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 27077672 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 21315641 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 31470635 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31470635 — Safety Biomarker (SAF): IL-6 and IL-10
Study 29788156 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29788156 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 29788156 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29788156 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 23086971 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 20735342 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16097363 — Surrogate Endpoint (SUR): Blood pressure
Study 9829378 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 23459407 — Surrogate Endpoint (SUR): Blood pressure
Study 23459407 — Surrogate Endpoint (SUR): Serum uric acid
Study 16571956 — Surrogate Endpoint (SUR): Blood pressure
Study 25542291 — Surrogate Endpoint (SUR): Blood pressure
Study 23733761 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 18264935 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10456487 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 1985165 — Predictive Biomarker (PRD): CR1 mRNA
Genes: CR1; C3BR
Study 1985165 — Predictive Biomarker (PRD): CR2 mRNA
Genes: CR2; C3DR
Study 6342362 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6342362 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1648026 — Surrogate Endpoint (SUR): Blood pressure
Study 20001457 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20001457 — Surrogate Endpoint (SUR): Blood pressure
Study 20001457 — Surrogate Endpoint (SUR): Serum potassium
Study 8145906 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 31175711 — Surrogate Endpoint (SUR): Blood pressure
Study 22103045 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 19696643 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19696643 — Monitoring Biomarker (MOI): Procalcitonin
Study 19696643 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19696643 — Safety Biomarker (SAF): Interleukin 1
Study 20362709 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 11284610 — Surrogate Endpoint (SUR): Blood pressure
Study 23890516 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23890516 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23890516 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23890516 — Surrogate Endpoint (SUR): Blood pressure
Study 21909448 — Predictive Biomarker (PRD): IVNS1ABP mRNA
Genes: IVNS1ABP; ARA3; FLARA3; KIAA0850; KLHL39; NS1; NS1BP; HSPC068
Study 8907209 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8907209 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25978741 — Surrogate Endpoint (SUR): Blood pressure
Study 22074851 — Surrogate Endpoint (SUR): Blood pressure
Study 22074851 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9458496 — Surrogate Endpoint (SUR): Serum calcium
Study 7924775 — Predictive Biomarker (PRD): RAPGEF5 mRNA
Genes: RAPGEF5; GFR; KIAA0277; MRGEF
Study 7924775 — Surrogate Endpoint (SUR): Blood pressure
Study 2894166 — Surrogate Endpoint (SUR): Blood pressure
Study 28202896 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25400252 — Surrogate Endpoint (SUR): Serum uric acid
Study 25400252 — Surrogate Endpoint (SUR): Serum creatinine
Study 18713548 — Predictive Biomarker (PRD): ASRGL1 mRNA
Genes: ASRGL1; ALP; CRASH