TrialPanorama/TrialPanorama-database huggingface dataset:
Study 20590759 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 15270789 — Predictive Biomarker (PRD): AIP mRNA
Genes: AIP; XAP2
Study 9543065 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 29124324 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 29124324 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16361368 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 31778310 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 31778310 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 31778310 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 2065411 — Surrogate Endpoint (SUR): Blood pressure
Study 25212745 — Predictive Biomarker (PRD): ALOX5 mRNA
Genes: ALOX5; LOG5
Study 17164834 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 17164834 — Surrogate Endpoint (SUR): Blood pressure
Study 15886432 — Surrogate Endpoint (SUR): Blood pressure
Study 24887458 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 26957979 — Surrogate Endpoint (SUR): Serum calcium
Study 24365779 — Predictive Biomarker (PRD): OGT mRNA
Genes: OGT
Study 24365779 — Safety Biomarker (SAF): Beta-N-acetylhexosaminidase
Genes: OGA; HEXC; KIAA0679; MEA5; MGEA5
Study 21480321 — Monitoring Biomarker (MOI): HBV DNA
Study 10915412 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 26375942 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 22650964 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 19541525 — Predictive Biomarker (PRD): NFIC mRNA
Genes: NFIC; NFI
Study 9641172 — Surrogate Endpoint (SUR): Blood pressure
Study 9641172 — Surrogate Endpoint (SUR): Serum creatinine
Study 9641172 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9641172 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29694272 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28512184 — Surrogate Endpoint (SUR): Blood pressure
Study 26281833 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 23530977 — Surrogate Endpoint (SUR): Blood pressure
Study 17942927 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7870348 — Predictive Biomarker (PRD): CPD mRNA
Genes: CPD
Study 7870348 — Predictive Biomarker (PRD): RAPH1 mRNA
Genes: RAPH1; ALS2CR18; ALS2CR9; KIAA1681; LPD; PREL2; RMO1
Study 28166654 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 28166654 — Surrogate Endpoint (SUR): Forced vital capacity
Study 21931228 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 16879471 — Surrogate Endpoint (SUR): Blood pressure
Study 12805245 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12805245 — Surrogate Endpoint (SUR): Blood pressure
Study 12805245 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12805245 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1339712 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 27355400 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 26742006 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 16075030 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16075030 — Surrogate Endpoint (SUR): Blood pressure
Study 10440565 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19052048 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 19052048 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12236276 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 7813225 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 25547237 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 6716325 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10854004 — Surrogate Endpoint (SUR): Blood pressure
Study 1544194 — Surrogate Endpoint (SUR): Blood pressure
Study 16209966 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31604061 — Safety Biomarker (SAF): Hyaluronic acid
Study 14971661 — Predictive Biomarker (PRD): FCGR1A mRNA
Genes: FCGR1A; FCG1; FCGR1; IGFR1
Study 11252686 — Surrogate Endpoint (SUR): Serum creatinine
Study 16361531 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 4009965 — Surrogate Endpoint (SUR): Blood pressure
Study 18496321 — Surrogate Endpoint (SUR): Blood pressure
Study 24814858 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 24422887 — Predictive Biomarker (PRD): CRHR1 mRNA
Genes: CRHR1; CRFR; CRFR1; CRHR
Study 17349681 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 11511432 — Surrogate Endpoint (SUR): Blood pressure
Study 11511432 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 27567447 — Predictive Biomarker (PRD): SLC10A3 mRNA
Genes: SLC10A3; DXS253E; P3
Study 20695686 — Surrogate Endpoint (SUR): Blood pressure
Study 17968001 — Surrogate Endpoint (SUR): Blood pressure
Study 22267390 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 22267390 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 22267390 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 22267390 — Predictive Biomarker (PRD): HSPA1B mRNA
Genes: HSPA1B; HSP72
Study 2455149 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2455149 — Surrogate Endpoint (SUR): Blood pressure
Study 25937837 — Surrogate Endpoint (SUR): Blood pressure
Study 19035150 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19035150 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19035150 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17235728 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 14635368 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 8851907 — Predictive Biomarker (PRD): CIT mRNA
Genes: CIT; CRIK; KIAA0949; STK21
Study 30580266 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 25175762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17520238 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 17520238 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 16361631 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 10438710 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 2111126 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 2111126 — Safety Biomarker (SAF): Interleukin 1
Study 29528768 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29528768 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29528768 — Surrogate Endpoint (SUR): Blood pressure
Study 29528768 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12148300 — Surrogate Endpoint (SUR): Blood pressure
Study 28958137 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 25590507 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 23235439 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 15618070 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26321524 — Safety Biomarker (SAF): Hyaluronic acid
Study 23301779 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2468978 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 28079825 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 21819167 — Surrogate Endpoint (SUR): Blood pressure
Study 17548726 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30550515 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30550515 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 25292398 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 30779529 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 25547983 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 20093333 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 20168306 — Surrogate Endpoint (SUR): Blood pressure
Study 18617314 — Predictive Biomarker (PRD): TH mRNA
Genes: TH; TYH
Study 18617314 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 18617314 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16143705 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16143705 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10574423 — Surrogate Endpoint (SUR): Blood pressure
Study 23150151 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 23150151 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 23150151 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 16732017 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15353428 — Surrogate Endpoint (SUR): Bone mineral density
Study 19369231 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 19369231 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 9700998 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9700998 — Surrogate Endpoint (SUR): Blood pressure
Study 21263198 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 12952258 — Predictive Biomarker (PRD): SERPINA1 mRNA
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209
Study 24906584 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 24260145 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 24260145 — Predictive Biomarker (PRD): TPH2 mRNA
Genes: TPH2; NTPH
Study 19009658 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 19009658 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16456383 — Surrogate Endpoint (SUR): Forced vital capacity
Study 10969106 — Surrogate Endpoint (SUR): Serum calcium
Study 8838764 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 3523938 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 23857507 — Monitoring Biomarker (MOI): HBV DNA
Study 22784897 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 22784897 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22784897 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12793558 — Surrogate Endpoint (SUR): Blood pressure
Study 9917782 — Surrogate Endpoint (SUR): Blood pressure
Study 27912104 — Predictive Biomarker (PRD): MARCKS mRNA
Genes: MARCKS; MACS; PRKCSL
Study 23880971 — Predictive Biomarker (PRD): TLR2
Genes: TIL4; CD282
Study 23880971 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22084333 — Surrogate Endpoint (SUR): Bone mineral density
Study 19501587 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 19501587 — Predictive Biomarker (PRD): OAT mRNA
Genes: OAT
Study 17016233 — Predictive Biomarker (PRD): CHEK2 mRNA
Genes: CHEK2; CDS1; CHK2; RAD53
Study 15799931 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 1789813 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29802136 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7915237 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 28755409 — Predictive Biomarker (PRD): GCGR mRNA
Genes: GCGR
Study 18496508 — Surrogate Endpoint (SUR): Blood pressure
Study 2573761 — Surrogate Endpoint (SUR): Blood pressure
Study 19424051 — Surrogate Endpoint (SUR): Bone mineral density
Study 17074116 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18191057 — Surrogate Endpoint (SUR): Blood pressure
Study 18191057 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18191057 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11081343 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22466947 — Predictive Biomarker (PRD): ST7 mRNA
Genes: ST7; FAM4A1; HELG; RAY1
Study 319541 — Surrogate Endpoint (SUR): Blood pressure
Study 12811500 — Surrogate Endpoint (SUR): Blood pressure
Study 30769128 — Predictive Biomarker (PRD): SON mRNA
Genes: SON; C21orf50; DBP5; KIAA1019; NREBP; HSPC310; HSPC312
Study 30083962 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 22925276 — Predictive Biomarker (PRD): TPH2 mRNA
Genes: TPH2; NTPH
Study 22925276 — Predictive Biomarker (PRD): 5HTT
Genes: SLC6A4; 5-HTT; SERT1
Study 1669525 — Surrogate Endpoint (SUR): Blood pressure
Study 19587249 — Surrogate Endpoint (SUR): Bone mineral density
Study 2658525 — Surrogate Endpoint (SUR): Blood pressure
Study 901695 — Surrogate Endpoint (SUR): Blood pressure
Study 25467016 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 25467016 — Surrogate Endpoint (SUR): Pathological complete response
Study 18028126 — Safety Biomarker (SAF): Fibroblast growth factor 1
Genes: FGF1
Study 26556736 — Surrogate Endpoint (SUR): Bone mineral density
Study 25662545 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25662545 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16639670 — Predictive Biomarker (PRD): PCLAF mRNA
Genes: PCLAF; KIAA0101; NS5ATP9; PAF; L5
Study 14616152 — Predictive Biomarker (PRD): RB1
Genes: RB; PPP1R130
Study 11062356 — Surrogate Endpoint (SUR): Bone mineral density
Study 27338954 — Surrogate Endpoint (SUR): Blood pressure
Study 17493418 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17493418 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27816115 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 26978497 — Surrogate Endpoint (SUR): Blood pressure
Study 24337064 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24337064 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29358433 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 29358433 — Surrogate Endpoint (SUR): Total kidney volume
Study 29358433 — Surrogate Endpoint (SUR): Blood pressure
Study 22958170 — Predictive Biomarker (PRD): DNMT1 mRNA
Genes: DNMT1; AIM; CXXC9; DNMT
Study 22958170 — Predictive Biomarker (PRD): MBD4 mRNA
Genes: MBD4; MED1
Study 22958170 — Predictive Biomarker (PRD): TET1 mRNA
Genes: TET1; CXXC6; KIAA1676; LCX
Study 12434259 — Surrogate Endpoint (SUR): Blood pressure
Study 3513529 — Surrogate Endpoint (SUR): Blood pressure
Study 27565938 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 17030560 — Predictive Biomarker (PRD): CXCR2 mRNA
Genes: CXCR2; IL8RB
Study 17030560 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9043967 — Surrogate Endpoint (SUR): Blood pressure
Study 23921272 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10791849 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 8651843 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 27796131 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23391676 — Surrogate Endpoint (SUR): Serum uric acid
Study 19470936 — Predictive Biomarker (PRD): MDM2 mRNA
Genes: MDM2
Study 19470936 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 19470936 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 19470936 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 16422960 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 9732932 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 12672184 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8704438 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 28724846 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17924845 — Predictive Biomarker (PRD): Glutamate carboxypeptidase II
Genes: FOLH1; FOLH; NAALAD1; PSM; PSMA; GIG27
Study 15083959 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 9831631 — Predictive Biomarker (PRD): MTTP mRNA
Genes: MTTP; MTP
Study 24169302 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 16935471 — Safety Biomarker (SAF): Reactive oxygen species
Study 8524486 — Surrogate Endpoint (SUR): Blood pressure
Study 19850248 — Surrogate Endpoint (SUR): Blood pressure
Study 15293890 — Surrogate Endpoint (SUR): Bone mineral density
Study 9403933 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31551217 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31551217 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 26395762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26395762 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 21811172 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 19622902 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 16677182 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 9666867 — Surrogate Endpoint (SUR): Bone mineral density
Study 8120554 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 2803050 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 31017470 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31017470 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31017470 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 16736519 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 8970892 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 8970892 — Surrogate Endpoint (SUR): Serum calcium
Study 8970892 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 8970892 — Surrogate Endpoint (SUR): Serum intact parathyroid hormone
Study 8970892 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 1728934 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21800004 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 21800004 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 21800004 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21800004 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 15033094 — Surrogate Endpoint (SUR): Blood pressure
Study 10681323 — Monitoring Biomarker (MOI): HBV DNA
Study 25815324 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 30280641 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 26120052 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 20167847 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20167847 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18499959 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 31017476 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 28387855 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28387855 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23660397 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 14969566 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 26460536 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 16923411 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 16086929 — Surrogate Endpoint (SUR): Blood pressure
Study 8965290 — Surrogate Endpoint (SUR): Blood pressure
Study 25833706 — Surrogate Endpoint (SUR): Blood pressure
Study 19066606 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 31066177 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 31066177 — Surrogate Endpoint (SUR): Blood pressure
Study 27584578 — Safety Biomarker (SAF): Argininosuccinate synthase
Genes: ASS1; ASS
Study 23263241 — Surrogate Endpoint (SUR): Blood pressure
Study 14745143 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24519752 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 24519752 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 22360924 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 20180606 — Surrogate Endpoint (SUR): Blood pressure
Study 15944337 — Surrogate Endpoint (SUR): Serum calcium
Study 15944337 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 29231497 — Predictive Biomarker (PRD): TG mRNA
Genes: TG