TrialPanorama/TrialPanorama-database huggingface dataset:
Study 24947057 — Predictive Biomarker (PRD): SLC12A3 mRNA
Genes: SLC12A3; NCC; TSC
Study 17366000 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17366000 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8194282 — Safety Biomarker (SAF): DHFR
Genes: DHFR1
Study 27928721 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26162698 — Predictive Biomarker (PRD): PHLDA2 mRNA
Genes: PHLDA2; BWR1C; HLDA2; IPL; TSSC3
Study 26162698 — Predictive Biomarker (PRD): CDKN1C mRNA
Genes: CDKN1C; KIP2
Study 26162698 — Predictive Biomarker (PRD): PEG3 mRNA
Genes: PEG3; KIAA0287; ZSCAN24
Study 26162698 — Predictive Biomarker (PRD): PEG10 mRNA
Genes: PEG10; EDR; KIAA1051e; MAR2; MART2; MEF3L1; RGAG3
Study 20540083 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 15541252 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15541252 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15564707 — Surrogate Endpoint (SUR): Blood pressure
Study 15564707 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11773207 — Surrogate Endpoint (SUR): Bone mineral density
Study 9561680 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2722224 — Surrogate Endpoint (SUR): Blood pressure
Study 16148057 — Predictive Biomarker (PRD): GAD2 mRNA
Genes: GAD2; GAD65
Study 19544817 — Predictive Biomarker (PRD): IDS mRNA
Genes: IDS; SIDS
Study 9535138 — Surrogate Endpoint (SUR): Blood pressure
Study 9535138 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1325010 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9465478 — Safety Biomarker (SAF): Interleukin 1
Study 24745696 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 11919227 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 7523778 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 7523778 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 7523778 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7523778 — Surrogate Endpoint (SUR): Blood pressure
Study 11751732 — Surrogate Endpoint (SUR): Blood pressure
Study 31056148 — Surrogate Endpoint (SUR): Blood pressure
Study 25444751 — Predictive Biomarker (PRD): HSPB1 mRNA
Genes: HSPB1; HSP27; HSP28
Study 25444751 — Predictive Biomarker (PRD): ADAMTS13 mRNA
Genes: ADAMTS13; C9orf8; UNQ6102/PRO20085
Study 22711752 — Surrogate Endpoint (SUR): Blood pressure
Study 18270944 — Surrogate Endpoint (SUR): Blood pressure
Study 15105167 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 11552922 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 26631004 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23332608 — Predictive Biomarker (PRD): PICALM mRNA
Genes: PICALM; CALM
Study 18926434 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 11005229 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 8973993 — Surrogate Endpoint (SUR): Blood pressure
Study 1456384 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 30820005 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 30820005 — Surrogate Endpoint (SUR): Serum calcium
Study 30820005 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22787067 — Surrogate Endpoint (SUR): Blood pressure
Study 22787067 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22787067 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25847478 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 11450709 — Surrogate Endpoint (SUR): Bone mineral density
Study 9506326 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 9506326 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 29984137 — Surrogate Endpoint (SUR): Blood pressure
Study 18821691 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18821691 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7728627 — Surrogate Endpoint (SUR): Forced vital capacity
Study 2045756 — Surrogate Endpoint (SUR): Blood pressure
Study 25781618 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21354681 — Surrogate Endpoint (SUR): Serum creatinine
Study 21354681 — Surrogate Endpoint (SUR): Blood pressure
Study 18568578 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 15890074 — Predictive Biomarker (PRD): RNPEP mRNA
Genes: RNPEP; APB
Study 29178536 — Surrogate Endpoint (SUR): Blood pressure
Study 19171400 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16719158 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 11067784 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 6430768 — Surrogate Endpoint (SUR): Blood pressure
Study 29696423 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 26292778 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 19106238 — Predictive Biomarker (PRD): IPP mRNA
Genes: IPP; KLHL27
Study 19106238 — Surrogate Endpoint (SUR): Blood pressure
Study 31477163 — Surrogate Endpoint (SUR): Blood pressure
Study 31477163 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23000015 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19188252 — Predictive Biomarker (PRD): MAPK3 mRNA
Genes: MAPK3; ERK1; PRKM3
Study 19188252 — Predictive Biomarker (PRD): MKNK1 mRNA
Genes: MKNK1; MNK1
Study 15530681 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8572850 — Surrogate Endpoint (SUR): Serum potassium
Study 8572850 — Surrogate Endpoint (SUR): Blood pressure
Study 26016467 — Safety Biomarker (SAF): DRD2
Study 30544179 — Surrogate Endpoint (SUR): Blood pressure
Study 30624670 — Surrogate Endpoint (SUR): Bone mineral density
Study 25384514 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22992330 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 17453342 — Predictive Biomarker (PRD): HOXB13 mRNA
Genes: HOXB13
Study 17453342 — Predictive Biomarker (PRD): IL17RB mRNA
Genes: IL17RB; CRL4; EVI27; IL17BR; UNQ2501/PRO19612
Study 17453342 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 171161 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11585118 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 11585118 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 11585118 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 8074426 — Safety Biomarker (SAF): Protein AMBP
Genes: AMBP; HCP; ITIL
Study 8074426 — Surrogate Endpoint (SUR): Blood pressure
Study 28939427 — Surrogate Endpoint (SUR): Blood pressure
Study 21415778 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 17159108 — Surrogate Endpoint (SUR): Bone mineral density
Study 15251831 — Surrogate Endpoint (SUR): Blood pressure
Study 7736741 — Surrogate Endpoint (SUR): Blood pressure
Study 30888253 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27148802 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 11053333 — Surrogate Endpoint (SUR): Blood pressure
Study 31501493 — Surrogate Endpoint (SUR): Blood pressure
Study 18285411 — Surrogate Endpoint (SUR): Bone mineral density
Study 11944023 — Predictive Biomarker (PRD): COG2 mRNA
Genes: COG2; LDLC
Study 11944023 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22135048 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 17224647 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 17224647 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 15199361 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15199361 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12530261 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 9661605 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 7659838 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30652510 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 26721137 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23320605 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 21792049 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 19397687 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11676979 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21898023 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21898023 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21898023 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21258131 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 16219013 — Surrogate Endpoint (SUR): Blood pressure
Study 2410720 — Surrogate Endpoint (SUR): Blood pressure
Study 27581208 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 24027184 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12892607 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 25421015 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 18956132 — Surrogate Endpoint (SUR): Bone mineral density
Study 17050216 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 14656363 — Predictive Biomarker (PRD): NANOS1 mRNA
Genes: NANOS1; NOS1
Study 14656363 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 2441175 — Surrogate Endpoint (SUR): Blood pressure
Study 29574866 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 23400742 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 23400742 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 23400742 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 12868787 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 2643866 — Surrogate Endpoint (SUR): Blood pressure
Study 2643866 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19801020 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 27118539 — Monitoring Biomarker (MOI): Procalcitonin
Study 10096265 — Surrogate Endpoint (SUR): Blood pressure
Study 31841475 — Predictive Biomarker (PRD): NDRG1 mRNA
Genes: NDRG1; CAP43; DRG1; RTP
Study 15879354 — Surrogate Endpoint (SUR): Bone mineral density
Study 15879354 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2065721 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27023009 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15785378 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15785378 — Surrogate Endpoint (SUR): Serum creatinine
Study 29595510 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19380134 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 9781930 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7828343 — Surrogate Endpoint (SUR): Serum testosterone
Study 31162530 — Surrogate Endpoint (SUR): Blood pressure
Study 20837369 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 31786829 — Surrogate Endpoint (SUR): Blood pressure
Study 17484511 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 17484511 — Predictive Biomarker (PRD): CPA1 mRNA
Genes: CPA1; CPA
Study 2592585 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 22784349 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 12697867 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 24118830 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 23219538 — Safety Biomarker (SAF): Hyaluronic acid
Study 18470667 — Surrogate Endpoint (SUR): Bone mineral density
Study 28958701 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15042614 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 15042614 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 29946728 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 29946728 — Predictive Biomarker (PRD): VEGF
Genes: VEGFA; VEGF-A; VPF
Study 29946728 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 2684309 — Surrogate Endpoint (SUR): Serum creatinine
Study 23332012 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 23332012 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23332012 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 23332012 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 23332012 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23332012 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23332012 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23332012 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23332012 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 3551127 — Surrogate Endpoint (SUR): Blood pressure
Study 8893656 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 23910908 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 17197641 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31058908 — Surrogate Endpoint (SUR): Blood pressure
Study 17601378 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17601378 — Surrogate Endpoint (SUR): Serum creatinine
Study 22100058 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22100058 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17956583 — Predictive Biomarker (PRD): TNFRSF18 mRNA
Genes: TNFRSF18; AITR; GITR; UNQ319/PRO364
Study 17956583 — Safety Biomarker (SAF): Cytotoxic T-lymphocyte protein 4
Genes: CTLA4; CD152
Study 15899957 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 9495395 — Surrogate Endpoint (SUR): Blood pressure
Study 7851072 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7851072 — Surrogate Endpoint (SUR): Blood pressure
Study 22093847 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 22093847 — Surrogate Endpoint (SUR): Blood pressure
Study 9808145 — Surrogate Endpoint (SUR): Serum calcium
Study 1136854 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 30907035 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30907035 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30907035 — Predictive Biomarker (PRD): MMP2 mRNA
Genes: MMP2; CLG4A
Study 25595565 — Surrogate Endpoint (SUR): Serum creatinine
Study 23107436 — Surrogate Endpoint (SUR): Blood pressure
Study 23107436 — Surrogate Endpoint (SUR): Serum potassium
Study 28394217 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 9212175 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 9212175 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8020032 — Surrogate Endpoint (SUR): Blood pressure
Study 8473405 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 25437032 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 16030050 — Surrogate Endpoint (SUR): Serum creatinine
Study 10543488 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 10543488 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 35824 — Predictive Biomarker (PRD): ASPRV1 mRNA
Genes: ASPRV1; SASP
Study 31818831 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31818831 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31818831 — Surrogate Endpoint (SUR): Blood pressure
Study 19877047 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19877047 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 15577136 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 29566189 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26852899 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 17587217 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 25425502 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 12362932 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 9854661 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 2079572 — Monitoring Biomarker (MOI): HBV DNA
Study 341941 — Surrogate Endpoint (SUR): Blood pressure
Study 31298217 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 21570514 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19539105 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19539105 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 12174920 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 29357480 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 22994682 — Surrogate Endpoint (SUR): Serum creatinine
Study 16962381 — Predictive Biomarker (PRD): ACTG1 mRNA
Genes: ACTG1; ACTG
Study 30957594 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 7662247 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29288055 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29288055 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23558303 — Surrogate Endpoint (SUR): Serum creatinine
Study 20854384 — Surrogate Endpoint (SUR): Blood pressure
Study 30646650 — Surrogate Endpoint (SUR): Forced vital capacity
Study 15793788 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7738625 — Surrogate Endpoint (SUR): Serum calcium
Study 28630863 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 24142869 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 24142869 — Predictive Biomarker (PRD): CYP2B6 mRNA
Genes: CYP2B6
Study 7956212 — Surrogate Endpoint (SUR): Blood pressure
Study 31903866 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31903866 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 28380009 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28380009 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 21062645 — Surrogate Endpoint (SUR): Blood pressure
Study 16900645 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16900645 — Surrogate Endpoint (SUR): Blood pressure
Study 31218369 — Predictive Biomarker (PRD): REST mRNA
Genes: REST; NRSF; XBR
Study 25837207 — Surrogate Endpoint (SUR): Blood pressure
Study 7564134 — Safety Biomarker (SAF): Hyaluronic acid
Study 6252744 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 22431865 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 22431865 — Predictive Biomarker (PRD): VKORC1 mRNA
Genes: VKORC1; VKOR; MSTP134; MSTP576; UNQ308/PRO351
Study 19066757 — Surrogate Endpoint (SUR): Blood pressure
Study 17283532 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 17283532 — Predictive Biomarker (PRD): CD82 mRNA
Genes: CD82; KAI1; SAR2; ST6; TSPAN27
Study 17283532 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 17283532 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 15971087 — Surrogate Endpoint (SUR): Blood pressure
Study 24060491 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 24060491 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24060491 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19811927 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 27227739 — Predictive Biomarker (PRD): ENG mRNA
Genes: ENG; END
Study 15848558 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 11803607 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341