TrialPanorama/TrialPanorama-database huggingface dataset:
Study 3907843 — Surrogate Endpoint (SUR): Blood pressure
Study 8809640 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 27684533 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 27684533 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 23644651 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 20663996 — Predictive Biomarker (PRD): ABL2 mRNA
Genes: ABL2; ABLL; ARG
Study 12515162 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 12515162 — Monitoring Biomarker (MOI): HBV DNA
Study 2543553 — Surrogate Endpoint (SUR): Blood pressure
Study 16918513 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 15307010 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11795863 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8431665 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8431665 — Surrogate Endpoint (SUR): Blood pressure
Study 24225740 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 18709511 — Predictive Biomarker (PRD): LARS1 mRNA
Genes: LARS1; KIAA1352; LARS
Study 8636748 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 2850904 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27661661 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 11026517 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 2110603 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29872922 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 14757848 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 25982053 — Surrogate Endpoint (SUR): Blood pressure
Study 23690582 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 21486960 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 12757345 — Predictive Biomarker (PRD): ADCY10 mRNA
Genes: ADCY10; SAC
Study 10883664 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 9339548 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 30464407 — Monitoring Biomarker (MOI): HBV DNA
Study 20231857 — Predictive Biomarker (PRD): CHRNA7 mRNA
Genes: CHRNA7; NACHRA7
Study 41550 — Surrogate Endpoint (SUR): Blood pressure
Study 11372675 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 9505918 — Surrogate Endpoint (SUR): Blood pressure
Study 3346087 — Surrogate Endpoint (SUR): Blood pressure
Study 27444642 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 19317164 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19317164 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 11707687 — Surrogate Endpoint (SUR): Blood pressure
Study 10892526 — Predictive Biomarker (PRD): HPSE mRNA
Genes: HPSE; HEP; HPA; HPA1; HPR1; HPSE1; HSE1
Study 30024539 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 30024539 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 7614504 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16826097 — Surrogate Endpoint (SUR): Bone mineral density
Study 31439215 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 31439215 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26261033 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 26261033 — Surrogate Endpoint (SUR): Serum creatinine
Study 19249432 — Predictive Biomarker (PRD): NLRP1 mRNA
Genes: NLRP1; CARD7; DEFCAP; KIAA0926; NAC; NALP1
Study 19249432 — Surrogate Endpoint (SUR): Serum creatinine
Study 7923660 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23999454 — Surrogate Endpoint (SUR): Blood pressure
Study 17335542 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 9215845 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 21677073 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19699832 — Surrogate Endpoint (SUR): Blood pressure
Study 19780243 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 26492775 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 26492775 — Predictive Biomarker (PRD): PEBP1 mRNA
Genes: PEBP1; PBP; PEBP
Study 26492775 — Surrogate Endpoint (SUR): Blood pressure
Study 22710021 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22710021 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22157475 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 9404828 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8121866 — Surrogate Endpoint (SUR): Blood pressure
Study 29659529 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24177413 — Surrogate Endpoint (SUR): Blood pressure
Study 2162239 — Surrogate Endpoint (SUR): Serum creatinine
Study 17765364 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 30607677 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 28376235 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 15281518 — Surrogate Endpoint (SUR): Blood pressure
Study 11497396 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 29733106 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 26541729 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 11736673 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27862898 — Surrogate Endpoint (SUR): Serum sodium
Study 26365758 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 31487739 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30640362 — Pharmacodynamic Biomarker (PDY): Insulin receptor substrate 1
Genes: IRS1
Study 21946897 — Predictive Biomarker (PRD): AZIN1 mRNA
Genes: AZIN1; OAZI; OAZIN
Study 9481276 — Surrogate Endpoint (SUR): Blood pressure
Study 3552360 — Surrogate Endpoint (SUR): Blood pressure
Study 1266667 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 31811645 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 10197673 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 7767539 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 7767539 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30076843 — Predictive Biomarker (PRD): HGD mRNA
Genes: HGD; HGO
Study 30076843 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 2108889 — Surrogate Endpoint (SUR): Serum luteinizing hormone
Study 7001332 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 21367761 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 15126148 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 11217092 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 26996268 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 25758370 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 23628045 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 9597571 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 2890903 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 27737393 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 27737393 — Surrogate Endpoint (SUR): Blood pressure
Study 19671656 — Surrogate Endpoint (SUR): Bone mineral density
Study 17472001 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 12086555 — Safety Biomarker (SAF): Interleukin 1
Study 19341122 — Predictive Biomarker (PRD): NLRP1 mRNA
Genes: NLRP1; CARD7; DEFCAP; KIAA0926; NAC; NALP1
Study 11557681 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 11557681 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 3293875 — Surrogate Endpoint (SUR): Blood pressure
Study 3293875 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31518645 — Predictive Biomarker (PRD): ELN mRNA
Genes: ELN
Study 26601156 — Predictive Biomarker (PRD): IGHMBP2 mRNA
Genes: IGHMBP2; SMBP2; SMUBP2
Study 8659761 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 8659761 — Safety Biomarker (SAF): 51Cr-EDTA
Study 3984771 — Surrogate Endpoint (SUR): Blood pressure
Study 29343509 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24980662 — Surrogate Endpoint (SUR): Blood pressure
Study 16042774 — Predictive Biomarker (PRD): SFTPB mRNA
Genes: SFTPB; SFTP3
Study 12443741 — Surrogate Endpoint (SUR): Blood pressure
Study 8952600 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7852490 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30939085 — Predictive Biomarker (PRD): TKTL1 mRNA
Genes: TKTL1; TKR; TKT2
Study 21544313 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 21544313 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 21544313 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 23122650 — Predictive Biomarker (PRD): CD52 mRNA
Genes: CD52; CDW52; HE5
Study 7759273 — Surrogate Endpoint (SUR): Blood pressure
Study 22087680 — Surrogate Endpoint (SUR): Serum creatinine
Study 848618 — Surrogate Endpoint (SUR): Blood pressure
Study 28138158 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22112682 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 9524901 — Surrogate Endpoint (SUR): Blood pressure
Study 20104178 — Surrogate Endpoint (SUR): Blood pressure
Study 16393321 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16393321 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 10497008 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21163116 — Surrogate Endpoint (SUR): Blood pressure
Study 31928690 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 31928690 — Predictive Biomarker (PRD): PIK3CA mRNA
Genes: PIK3CA
Study 31928690 — Predictive Biomarker (PRD): Hormone receptor
Study 26328497 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26328497 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 26328497 — Surrogate Endpoint (SUR): Blood pressure
Study 19825328 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 16715914 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16715914 — Surrogate Endpoint (SUR): Blood pressure
Study 11465652 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11465652 — Surrogate Endpoint (SUR): Blood pressure
Study 11465652 — Surrogate Endpoint (SUR): Serum creatinine
Study 8276045 — Safety Biomarker (SAF): Glutamate dehydrogenase
Study 2880692 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 12814161 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 8857916 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8857916 — Surrogate Endpoint (SUR): Serum triglycerides
Study 27766771 — Surrogate Endpoint (SUR): Serum creatinine
Study 17955358 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 11907945 — Surrogate Endpoint (SUR): Bone mineral density
Study 22491708 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12732859 — Surrogate Endpoint (SUR): Blood pressure
Study 3904393 — Surrogate Endpoint (SUR): Blood pressure
Study 28916603 — Surrogate Endpoint (SUR): Blood pressure
Study 23940221 — Predictive Biomarker (PRD): RUNX1 mRNA
Genes: RUNX1; AML1; CBFA2
Study 16424846 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 31346968 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 20951491 — Surrogate Endpoint (SUR): Blood pressure
Study 7917912 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7917912 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 7917912 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 2844088 — Surrogate Endpoint (SUR): Blood pressure
Study 24285491 — Surrogate Endpoint (SUR): Bone mineral density
Study 23645236 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 23645236 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9356537 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9356537 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10321658 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10321658 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8755119 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 8755119 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 1722793 — Surrogate Endpoint (SUR): Serum testosterone
Study 7042699 — Surrogate Endpoint (SUR): Blood pressure
Study 17230055 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 17230055 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 14715560 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30219460 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 15953681 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 7727330 — Surrogate Endpoint (SUR): Blood pressure
Study 28483221 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 24832461 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24832461 — Surrogate Endpoint (SUR): Serum creatinine
Study 16739327 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 8585042 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 31859911 — Monitoring Biomarker (MOI): Heme oxygenase 1
Genes: HMOX1; HO; HO1
Study 19358783 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19358783 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15207399 — Surrogate Endpoint (SUR): Blood pressure
Study 8076623 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 1103606 — Surrogate Endpoint (SUR): Blood pressure
Study 24504937 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22325984 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22325984 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22325984 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 10367822 — Surrogate Endpoint (SUR): Blood pressure
Study 24952577 — Predictive Biomarker (PRD): IDH1 mRNA
Genes: IDH1; PICD
Study 24952577 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 24952577 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 24952577 — Predictive Biomarker (PRD): IDH2 mRNA
Genes: IDH2
Study 22265810 — Surrogate Endpoint (SUR): Blood pressure
Study 22265810 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16210721 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 23713218 — Predictive Biomarker (PRD): RRAD mRNA
Genes: RRAD; RAD
Study 23713218 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 8973788 — Surrogate Endpoint (SUR): Blood pressure
Study 15801579 — Surrogate Endpoint (SUR): Blood pressure
Study 8080348 — Surrogate Endpoint (SUR): Blood pressure
Study 31142530 — Surrogate Endpoint (SUR): Blood pressure
Study 28839339 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC18A2 mRNA
Genes: SLC18A2; SVMT; VMAT2
Study 17350367 — Surrogate Endpoint (SUR): Blood pressure
Study 7884017 — Surrogate Endpoint (SUR): Serum creatinine
Study 21279976 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 14595564 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7685442 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 8365747 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 3060889 — Surrogate Endpoint (SUR): Blood pressure
Study 10546924 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 28146065 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28819835 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 10617948 — Surrogate Endpoint (SUR): Serum uric acid
Study 1512337 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1512337 — Surrogate Endpoint (SUR): Blood pressure
Study 24889137 — Surrogate Endpoint (SUR): Blood pressure
Study 22863159 — Surrogate Endpoint (SUR): Blood pressure
Study 12908893 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 2550646 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21939942 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 21939942 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 23660738 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22545106 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 22545106 — Predictive Biomarker (PRD): CASP4 mRNA
Genes: CASP4; ICH2
Study 22545106 — Predictive Biomarker (PRD): NAIP mRNA
Genes: NAIP; BIRC1
Study 22545106 — Predictive Biomarker (PRD): SORL1 mRNA
Genes: SORL1; C11orf32
Study 22545106 — Predictive Biomarker (PRD): ANAPC5 mRNA
Genes: ANAPC5; APC5
Study 22545106 — Predictive Biomarker (PRD): RHOB mRNA
Genes: RHOB; ARH6; ARHB
Study 2574728 — Surrogate Endpoint (SUR): Blood pressure
Study 30689903 — Predictive Biomarker (PRD): E2F1 mRNA
Genes: E2F1; RBBP3
Study 19826110 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 15467219 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 4018470 — Surrogate Endpoint (SUR): Blood pressure
Study 28708766 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 23863960 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 1750429 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1750429 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31778601 — Predictive Biomarker (PRD): LTA mRNA
Genes: LTA; TNFB; TNFSF1
Study 31778601 — Predictive Biomarker (PRD): VASP mRNA
Genes: VASP
Study 31778601 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 18756743 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 8868980 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24802413 — Predictive Biomarker (PRD): Hormone receptor
Study 1665493 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 30037426 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 27618825 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22334121 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 17932908 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 15804733 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15804733 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15804733 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 15804733 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 7191779 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 30343508 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 21833823 — Predictive Biomarker (PRD): PYCARD mRNA
Genes: PYCARD; ASC; CARD5; TMS1
Study 7733514 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19222841 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 16863750 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 27107490 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9539185 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 2598986 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 16115390 — Predictive Biomarker (PRD): LTB mRNA
Genes: LTB; TNFC; TNFSF3
Study 16115390 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 16960170 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27141849 — Predictive Biomarker (PRD): TRPA1 mRNA
Genes: TRPA1; ANKTM1
Study 20051119 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 2691013 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 2691013 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 29952675 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21495524 — Predictive Biomarker (PRD): DSE mRNA
Genes: DSE; SART2
Study 9174314 — Surrogate Endpoint (SUR): Blood pressure
Study 26572896 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 26572896 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 26572896 — Safety Biomarker (SAF): DRD2
Study 16052393 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 10356829 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10356829 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 10356829 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 10356829 — Surrogate Endpoint (SUR): Blood pressure
Study 10356829 — Surrogate Endpoint (SUR): Forced vital capacity
Study 6185014 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 26364288 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 2511776 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 25231512 — Surrogate Endpoint (SUR): Blood pressure
Study 24168077 — Safety Biomarker (SAF): Hyaluronic acid
Study 19546359 — Surrogate Endpoint (SUR): Serum creatinine
Study 18322594 — Monitoring Biomarker (MOI): HBV DNA