TrialPanorama/TrialPanorama-database huggingface dataset:
Study 28089476 — Safety Biomarker (SAF): Reactive oxygen species
Study 26149722 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19789402 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19789402 — Surrogate Endpoint (SUR): Blood pressure
Study 26712786 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23426035 — Surrogate Endpoint (SUR): Blood pressure
Study 1637794 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31058977 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31058977 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 20160750 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 18839781 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11500190 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 1332102 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 8788535 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 26363985 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26363985 — Predictive Biomarker (PRD): Hormone receptor
Study 19922882 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14993020 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 26888146 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 11127936 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11127936 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31500670 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 28195952 — Predictive Biomarker (PRD): CYBC1 mRNA
Genes: CYBC1; C17orf62; EROS
Study 16817913 — Safety Biomarker (SAF): Interleukin 1
Study 30160521 — Surrogate Endpoint (SUR): Serum triglycerides
Study 30160521 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12886816 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 30085292 — Surrogate Endpoint (SUR): Blood pressure
Study 27712772 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 20228404 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10937983 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6753891 — Surrogate Endpoint (SUR): Blood pressure
Study 31049877 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31049877 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25644340 — Surrogate Endpoint (SUR): Blood pressure
Study 17195531 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29547834 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 11783143 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 11783143 — Predictive Biomarker (PRD): FN1 mRNA
Genes: FN1; FN
Study 11783143 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11783143 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 11783143 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11783143 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11783143 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 11783143 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 11783143 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7762505 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 7762505 — Surrogate Endpoint (SUR): Blood pressure
Study 12169045 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 2180267 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2180267 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7813389 — Safety Biomarker (SAF): L-acetylcarnitine
Study 24166906 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 24166906 — Safety Biomarker (SAF): Fibroblast growth factor 1
Genes: FGF1
Study 15356084 — Surrogate Endpoint (SUR): Blood pressure
Study 15356084 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15356084 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 11458055 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 2977273 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 8156307 — Surrogate Endpoint (SUR): Bone mineral density
Study 31185942 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31185942 — Safety Biomarker (SAF): IL-6 and IL-10
Study 29249140 — Predictive Biomarker (PRD): SCARA3 mRNA
Genes: SCARA3; CSR
Study 29249140 — Predictive Biomarker (PRD): GAL3ST1 mRNA
Genes: GAL3ST1; CST
Study 20154074 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 20154074 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 20154074 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 20154074 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31623760 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 12011785 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 2527544 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2527544 — Surrogate Endpoint (SUR): Blood pressure
Study 31197361 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 28087178 — Surrogate Endpoint (SUR): Serum uric acid
Study 14755979 — Surrogate Endpoint (SUR): Blood pressure
Study 10727313 — Surrogate Endpoint (SUR): Serum creatinine
Study 2933999 — Surrogate Endpoint (SUR): Blood pressure
Study 2933999 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 31053142 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17387332 — Predictive Biomarker (PRD): DRD4 mRNA
Genes: DRD4
Study 17387332 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 12830340 — Surrogate Endpoint (SUR): Blood pressure
Study 11273913 — Surrogate Endpoint (SUR): Blood pressure
Study 8510388 — Surrogate Endpoint (SUR): Serum potassium
Study 27496229 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 27496229 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 27496229 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 21200437 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17526320 — Surrogate Endpoint (SUR): Blood pressure
Study 16003289 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 12462291 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12462291 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31376708 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 26061572 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 24343322 — Predictive Biomarker (PRD): LSAMP mRNA
Genes: LSAMP; IGLON3; LAMP
Study 2475701 — Surrogate Endpoint (SUR): Blood pressure
Study 21883902 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 11240234 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 9469326 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 1967227 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1967227 — Surrogate Endpoint (SUR): Blood pressure
Study 31286931 — Surrogate Endpoint (SUR): Blood pressure
Study 29066863 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Nqo1 mRNA
Genes: NQO1; DIA4; NMOR1
Study 15302727 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 9493664 — Surrogate Endpoint (SUR): Forced vital capacity
Study 2502583 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 2502583 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 7857363 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 7857363 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 7857363 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31044290 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 28727817 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 25437881 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26595801 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 15465740 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 20667937 — Surrogate Endpoint (SUR): Blood pressure
Study 20667937 — Surrogate Endpoint (SUR): Serum triglycerides
Study 12897033 — Surrogate Endpoint (SUR): Forced vital capacity
Study 3079687 — Surrogate Endpoint (SUR): Serum sodium
Study 22077482 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 20427397 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 16258776 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 12384804 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 7624601 — Surrogate Endpoint (SUR): Blood pressure
Study 2655611 — Surrogate Endpoint (SUR): Blood pressure
Study 30850240 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30850240 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 3567042 — Surrogate Endpoint (SUR): Blood pressure
Study 27558788 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 8914118 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 31812956 — Surrogate Endpoint (SUR): Blood pressure
Study 19105915 — Surrogate Endpoint (SUR): Blood pressure
Study 19105915 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19105915 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7830631 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7830631 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2575981 — Predictive Biomarker (PRD): MAVS mRNA
Genes: MAVS; IPS1; KIAA1271; VISA
Study 25689244 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 6430439 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 31099333 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31099333 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31099333 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 31099333 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 24436297 — Surrogate Endpoint (SUR): Blood pressure
Study 12111109 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 9892304 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30586738 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28063245 — Predictive Biomarker (PRD): VKORC1 mRNA
Genes: VKORC1; VKOR; MSTP134; MSTP576; UNQ308/PRO351
Study 28063245 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 21169640 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17598009 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 17598009 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 15373928 — Surrogate Endpoint (SUR): Serum potassium
Study 2959426 — Surrogate Endpoint (SUR): Blood pressure
Study 20670726 — Surrogate Endpoint (SUR): Blood pressure
Study 11813764 — Surrogate Endpoint (SUR): Blood pressure
Study 28619701 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 15621710 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 28903510 — Predictive Biomarker (PRD): RALA mRNA
Genes: RALA; RAL
Study 28903510 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 21240871 — Surrogate Endpoint (SUR): Blood pressure
Study 21240871 — Surrogate Endpoint (SUR): Serum potassium
Study 16505413 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 8891847 — Monitoring Biomarker (MOI): HBV DNA
Study 1381022 — Surrogate Endpoint (SUR): Blood pressure
Study 6383655 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 6383655 — Surrogate Endpoint (SUR): Blood pressure
Study 31126299 — Predictive Biomarker (PRD): FTO mRNA
Genes: FTO; KIAA1752
Study 31126299 — Predictive Biomarker (PRD): IRX3 mRNA
Genes: IRX3; IRXB1
Study 21199966 — Predictive Biomarker (PRD): LTB4R mRNA
Genes: LTB4R; BLT; BLT1; BLTR; CMKRL1; GPR16; P2RY7
Study 29763623 — Predictive Biomarker (PRD): POLE mRNA
Genes: POLE; POLE1
Study 29763623 — Predictive Biomarker (PRD): POLD1 mRNA
Genes: POLD1; POLD
Study 29763623 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 9124243 — Surrogate Endpoint (SUR): Blood pressure
Study 19328598 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 16827430 — Surrogate Endpoint (SUR): Blood pressure
Study 16827430 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 12662378 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 10511770 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10511770 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 10511770 — Predictive Biomarker (PRD): ANTXR1 mRNA
Genes: ANTXR1; ATR; TEM8
Study 10511770 — Safety Biomarker (SAF): ACE
Genes: ACE1; CD143
Study 7556745 — Surrogate Endpoint (SUR): Blood pressure
Study 25741580 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 23446957 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10765078 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 9206199 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24290850 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 7910230 — Predictive Biomarker (PRD): TAOK2 mRNA
Genes: TAOK2; KIAA0881; MAP3K17; PSK; PSK1; UNQ2971/PRO7431
Study 31959416 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 31959416 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 29369834 — Surrogate Endpoint (SUR): Serum sodium
Study 10489003 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 1767541 — Surrogate Endpoint (SUR): Serum calcium
Study 20415574 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2111239 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6653648 — Surrogate Endpoint (SUR): Blood pressure
Study 7621766 — Predictive Biomarker (PRD): LEP mRNA
Genes: LEP; OB; OBS
Study 28361235 — Surrogate Endpoint (SUR): Serum uric acid
Study 23910207 — Surrogate Endpoint (SUR): Probing pocket depth
Study 21764705 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 21764705 — Surrogate Endpoint (SUR): Blood pressure
Study 23480528 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 21181138 — Predictive Biomarker (PRD): DRD1 mRNA
Genes: DRD1
Study 21181138 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 18584240 — Predictive Biomarker (PRD): PAG1 mRNA
Genes: PAG1; CBP; PAG
Study 2414590 — Surrogate Endpoint (SUR): Blood pressure
Study 8461542 — Surrogate Endpoint (SUR): Bone mineral density
Study 2945717 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18485132 — Surrogate Endpoint (SUR): Blood pressure
Study 12774138 — Surrogate Endpoint (SUR): Blood pressure
Study 28419368 — Predictive Biomarker (PRD): LTA4H mRNA
Genes: LTA4H; LTA4
Study 16597076 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 16597076 — Surrogate Endpoint (SUR): Forced vital capacity
Study 27252432 — Safety Biomarker (SAF): Hyaluronic acid
Study 20687400 — Predictive Biomarker (PRD): DHPS mRNA
Genes: DHPS; DS
Study 8656661 — Surrogate Endpoint (SUR): Blood pressure
Study 1801883 — Predictive Biomarker (PRD): TAC1 mRNA
Genes: TAC1; NKA; NKNA; TAC2
Study 29142926 — Surrogate Endpoint (SUR): Total kidney volume
Study 21315219 — Surrogate Endpoint (SUR): Blood pressure
Study 17059993 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17059993 — Surrogate Endpoint (SUR): Blood pressure
Study 17059993 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1312002 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31239321 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 19685375 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19685375 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19685375 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 19685375 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15234425 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15234425 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15234425 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9091008 — Surrogate Endpoint (SUR): Blood pressure
Study 22324939 — Predictive Biomarker (PRD): GNL3 mRNA
Genes: GNL3; E2IG3; NS
Study 20669673 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20669673 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 18609695 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 12049852 — Predictive Biomarker (PRD): ALAD mRNA
Genes: ALAD
Study 27513247 — Surrogate Endpoint (SUR): Blood pressure
Study 24337079 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC6A4 mRNA
Genes: SLC6A4; HTT; SERT
Study 24337079 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 19223156 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 19223156 — Safety Biomarker (SAF): BDNF
Study 25876832 — Surrogate Endpoint (SUR): Blood pressure
Study 25885986 — Surrogate Endpoint (SUR): Blood pressure
Study 17225162 — Pharmacodynamic Biomarker (PDY): Mismatch negativity
Study 11472614 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 3126635 — Surrogate Endpoint (SUR): Blood pressure
Study 9249638 — Predictive Biomarker (PRD): HAL mRNA
Genes: HAL; HIS
Study 8272333 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 22306290 — Surrogate Endpoint (SUR): Blood pressure
Study 18093716 — Surrogate Endpoint (SUR): Blood pressure
Study 10632912 — Surrogate Endpoint (SUR): Blood pressure
Study 8311533 — Predictive Biomarker (PRD): GCA mRNA
Genes: GCA; GCL
Study 2423803 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27098346 — Surrogate Endpoint (SUR): Blood pressure
Study 24102912 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 10735462 — Surrogate Endpoint (SUR): Blood pressure
Study 1392423 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 3904233 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 23959209 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23959209 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12860257 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 31482309 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 24160442 — Surrogate Endpoint (SUR): Blood pressure
Study 14519176 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 8884548 — Surrogate Endpoint (SUR): Blood pressure
Study 1303480 — Surrogate Endpoint (SUR): Blood pressure
Study 27055970 — Surrogate Endpoint (SUR): Serum triglycerides
Study 27055970 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27055970 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 15777554 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15777554 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11170979 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11170979 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 11170979 — Safety Biomarker (SAF): Interleukin 12
Study 3202339 — Surrogate Endpoint (SUR): Blood pressure
Study 30175930 — Surrogate Endpoint (SUR): Blood pressure
Study 30175930 — Surrogate Endpoint (SUR): Serum creatinine
Study 29933531 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29933531 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29933531 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 18534287 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18534287 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18534287 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 6751366 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24488324 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 28750828 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19421167 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 30097052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17846974 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1411248 — Surrogate Endpoint (SUR): Blood pressure
Study 29059146 — Safety Biomarker (SAF): Hyaluronic acid
Study 21930607 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4