TrialPanorama/TrialPanorama-database huggingface dataset:
Study 27725911 — Predictive Biomarker (PRD): NDP mRNA
Genes: NDP; EVR2
Study 3828955 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 27510539 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 18752143 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 1347757 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1347757 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1347757 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2863220 — Surrogate Endpoint (SUR): Blood pressure
Study 8227863 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 28148501 — Surrogate Endpoint (SUR): Serum uric acid
Study 15531696 — Surrogate Endpoint (SUR): Bone mineral density
Study 9757152 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 3042356 — Surrogate Endpoint (SUR): Blood pressure
Study 28173897 — Predictive Biomarker (PRD): EBF1 mRNA
Genes: EBF1; COE1; EBF
Study 16930215 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 10894865 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 1589588 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 6747142 — Predictive Biomarker (PRD): KCNN1 mRNA
Genes: KCNN1; SK
Study 6747142 — Predictive Biomarker (PRD): RANGAP1 mRNA
Genes: RANGAP1; KIAA1835; SD
Study 27856202 — Surrogate Endpoint (SUR): Blood pressure
Study 25264877 — Surrogate Endpoint (SUR): Blood pressure
Study 19874572 — Predictive Biomarker (PRD): HFE mRNA
Genes: HFE; HLAH
Study 16386539 — Surrogate Endpoint (SUR): Blood pressure
Study 16386539 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22941691 — Surrogate Endpoint (SUR): Blood pressure
Study 1836100 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31045798 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31045798 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31045798 — Surrogate Endpoint (SUR): Blood pressure
Study 26919177 — Surrogate Endpoint (SUR): Blood pressure
Study 16392300 — Predictive Biomarker (PRD): CGN mRNA
Genes: CGN; KIAA1319
Study 16392300 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16392300 — Surrogate Endpoint (SUR): Blood pressure
Study 140029 — Surrogate Endpoint (SUR): Blood pressure
Study 28595744 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 19112166 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 19112166 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19112166 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19112166 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19112166 — Surrogate Endpoint (SUR): Blood pressure
Study 29266189 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 9197872 — Safety Biomarker (SAF): Reactive oxygen species
Study 9197872 — Surrogate Endpoint (SUR): Blood pressure
Study 9197872 — Surrogate Endpoint (SUR): Serum uric acid
Study 2988589 — Surrogate Endpoint (SUR): Blood pressure
Study 9062091 — Surrogate Endpoint (SUR): Serum creatinine
Study 28885296 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 26226096 — Predictive Biomarker (PRD): LARS1 mRNA
Genes: LARS1; KIAA1352; LARS
Study 20022087 — Safety Biomarker (SAF): Hyaluronic acid
Study 12492665 — Surrogate Endpoint (SUR): Blood pressure
Study 30829658 — Surrogate Endpoint (SUR): Blood pressure
Study 28459397 — Pharmacodynamic Biomarker (PDY): Cathepsin S
Genes: CTSS
Study 19064965 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 15458276 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15458276 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15458276 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9683309 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 17013435 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17013435 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9595578 — Surrogate Endpoint (SUR): Blood pressure
Study 17130196 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 8472740 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 12161978 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 10528604 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 25889322 — Safety Biomarker (SAF): Hyaluronic acid
Study 24917003 — Surrogate Endpoint (SUR): Serum testosterone
Study 19863831 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31466119 — Predictive Biomarker (PRD): JAK1 mRNA
Genes: JAK1; JAK1A; JAK1B
Study 31466119 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 31466119 — Predictive Biomarker (PRD): JAK3 mRNA
Genes: JAK3
Study 28113021 — Predictive Biomarker (PRD): FST mRNA
Genes: FST
Study 18240230 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12723463 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 26104243 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24555904 — Predictive Biomarker (PRD): SV2A mRNA
Genes: SV2A; KIAA0736; PSEC0174
Study 24555904 — Predictive Biomarker (PRD): SNAP25 mRNA
Genes: SNAP25; SNAP
Study 15924813 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31268872 — Surrogate Endpoint (SUR): Blood pressure
Study 21933039 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21933039 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21933039 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17218919 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 7786835 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7786835 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2710907 — Surrogate Endpoint (SUR): Blood pressure
Study 25451868 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 10511064 — Surrogate Endpoint (SUR): Blood pressure
Study 7735495 — Surrogate Endpoint (SUR): Blood pressure
Study 2285009 — Surrogate Endpoint (SUR): Blood pressure
Study 27904931 — Predictive Biomarker (PRD): LHB mRNA
Genes: LHB
Study 23072086 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 19424699 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 11260417 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 11260417 — Safety Biomarker (SAF): Hyaluronic acid
Study 25504466 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 23630366 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20627703 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 16175942 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16175942 — Surrogate Endpoint (SUR): Blood pressure
Study 10745299 — Surrogate Endpoint (SUR): Bone mineral density
Study 19175450 — Predictive Biomarker (PRD): NID1 mRNA
Genes: NID1; NID
Study 26670916 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 25109850 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 22974536 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 10216807 — Surrogate Endpoint (SUR): Blood pressure
Study 31503408 — Surrogate Endpoint (SUR): Blood pressure
Study 16091239 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CARTPT mRNA
Genes: CARTPT; CART
Study 31959014 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 31959014 — Surrogate Endpoint (SUR): Blood pressure
Study 31959014 — Surrogate Endpoint (SUR): Serum creatinine
Study 29068578 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24471247 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21796050 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 11905866 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11905866 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29770445 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23719718 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 23719718 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor receptor
Study 23719718 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20946656 — Surrogate Endpoint (SUR): Bone mineral density
Study 10228251 — Surrogate Endpoint (SUR): Blood pressure
Study 20479419 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15625087 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 28836458 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20234140 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30511963 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30511963 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 23875707 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 23875707 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): CCR2 mRNA
Genes: CCR2; CMKBR2
Study 23875707 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 23875707 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21957032 — Predictive Biomarker (PRD): PZP mRNA
Genes: PZP; CPAMD6
Study 21957032 — Safety Biomarker (SAF): Vitamin K-dependent protein S
Genes: PROS1; PROS
Study 17910651 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 17910651 — Predictive Biomarker (PRD): RAPGEF5 mRNA
Genes: RAPGEF5; GFR; KIAA0277; MRGEF
Study 17910651 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 8400091 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8400091 — Surrogate Endpoint (SUR): Blood pressure
Study 8658378 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 2878597 — Surrogate Endpoint (SUR): Blood pressure
Study 30175606 — Safety Biomarker (SAF): Hyaluronic acid
Study 19403553 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17446413 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 17446413 — Surrogate Endpoint (SUR): Blood pressure
Study 15213282 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 17632023 — Surrogate Endpoint (SUR): Forced vital capacity
Study 16893984 — Predictive Biomarker (PRD): MCC mRNA
Genes: MCC
Study 16893984 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 2058822 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 24368514 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24368514 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22804353 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 10634401 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 30501447 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15007512 — Safety Biomarker (SAF): Reactive oxygen species
Study 2481775 — Surrogate Endpoint (SUR): Blood pressure
Study 21632228 — Surrogate Endpoint (SUR): Blood pressure
Study 12116023 — Monitoring Biomarker (MOI): HBV DNA
Study 2675895 — Surrogate Endpoint (SUR): Serum creatinine
Study 25870057 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 19061743 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 31789554 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23368828 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 6347229 — Surrogate Endpoint (SUR): Blood pressure
Study 31389784 — Predictive Biomarker (PRD): PI3 mRNA
Genes: PI3; WAP3; WFDC14
Study 29739371 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 28261955 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26344014 — Surrogate Endpoint (SUR): Blood pressure
Study 23150685 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 9399007 — Predictive Biomarker (PRD): TH mRNA
Genes: TH; TYH
Study 23532477 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12618946 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11193166 — Pharmacodynamic Biomarker (PDY): Amyloid beta peptide (1-40)
Genes: APP; A4; AD1
Study 27734319 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 23011911 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 23011911 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 21736599 — Surrogate Endpoint (SUR): Probing pocket depth
Study 15521216 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 2572101 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 2572101 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23893178 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 27459535 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30205906 — Surrogate Endpoint (SUR): Blood pressure
Study 30376130 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23764202 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 23764202 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 14633326 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 15864233 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15864233 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21574826 — Predictive Biomarker (PRD): PLG mRNA
Genes: PLG
Study 17326911 — Surrogate Endpoint (SUR): Blood pressure
Study 16013016 — Monitoring Biomarker (MOI): Procalcitonin
Study 16013016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19558387 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21741057 — Surrogate Endpoint (SUR): Bone mineral density
Study 3299395 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3299395 — Surrogate Endpoint (SUR): Blood pressure
Study 26917477 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 25569481 — Surrogate Endpoint (SUR): Blood pressure
Study 1725550 — Surrogate Endpoint (SUR): Blood pressure
Study 26773574 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 12810614 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12810614 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 17599424 — Surrogate Endpoint (SUR): Blood pressure
Study 17599424 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17599424 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31779461 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 9818665 — Safety Biomarker (SAF): Hyaluronic acid
Study 2401100 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 19211261 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 19211261 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 19211261 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 19211261 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 16890832 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9205938 — Surrogate Endpoint (SUR): Blood pressure
Study 7950501 — Surrogate Endpoint (SUR): Bone mineral density
Study 7950501 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 17300951 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 17300951 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17300951 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 17300951 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 17300951 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10965090 — Predictive Biomarker (PRD): STC1 mRNA
Genes: STC1; STC
Study 26865043 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 26865043 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24196189 — Surrogate Endpoint (SUR): Blood pressure
Study 20158973 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30653534 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 30653534 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 14981370 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 19040343 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 17217716 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 10981168 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10981168 — Surrogate Endpoint (SUR): Blood pressure
Study 9105649 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9105649 — Surrogate Endpoint (SUR): Blood pressure
Study 25085036 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16385384 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 30521147 — Predictive Biomarker (PRD): SLC15A1 mRNA
Genes: SLC15A1; PEPT1
Study 30202408 — Predictive Biomarker (PRD): SIRPA mRNA
Genes: SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
Study 30089614 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22553354 — Predictive Biomarker (PRD): ZBTB10 mRNA
Genes: ZBTB10; RINZF; RINZFC
Study 7893297 — Predictive Biomarker (PRD): LAT mRNA
Genes: LAT
Study 2128929 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 19884554 — Predictive Biomarker (PRD): Ribonucleoside-diphosphate reductase large subunit
Genes: RRM1; RR1
Study 19884554 — Predictive Biomarker (PRD): DNA excision repair protein ERCC-1
Genes: ERCC1
Study 15316128 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15316128 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9205823 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9205823 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9205823 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23631832 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19050050 — Surrogate Endpoint (SUR): Bone mineral density
Study 23880195 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18186973 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 17010806 — Surrogate Endpoint (SUR): Blood pressure
Study 9826312 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9826312 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 31222344 — Predictive Biomarker (PRD): HSPD1 mRNA
Genes: HSPD1; HSP60
Study 31222344 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17200474 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 15070948 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7912766 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 31562758 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 31562758 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 19449015 — Predictive Biomarker (PRD): STC1 mRNA
Genes: STC1; STC
Study 19449015 — Predictive Biomarker (PRD): NTS mRNA
Genes: NTS
Study 19660042 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 9205940 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31833938 — Surrogate Endpoint (SUR): Bone mineral density
Study 21477901 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16779731 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12032393 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 25494974 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 22616628 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 15262456 — Surrogate Endpoint (SUR): Blood pressure
Study 15262456 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1631876 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 6431795 — Surrogate Endpoint (SUR): Blood pressure
Study 31968059 — Predictive Biomarker (PRD): PTS mRNA
Genes: PTS