TrialPanorama/TrialPanorama-database huggingface dataset:
Study 24311723 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 10907971 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28904371 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 24158664 — Surrogate Endpoint (SUR): Blood pressure
Study 30138422 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 18728024 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 15811142 — Surrogate Endpoint (SUR): Blood pressure
Study 21367921 — Surrogate Endpoint (SUR): Serum sodium
Study 17173900 — Surrogate Endpoint (SUR): Bone mineral density
Study 31583436 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 28183276 — Predictive Biomarker (PRD): MTR mRNA
Genes: MTR
Study 23726373 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 20110084 — Predictive Biomarker (PRD): PDE1A mRNA
Genes: PDE1A
Study 20110084 — Predictive Biomarker (PRD): PDE1C mRNA
Genes: PDE1C
Study 20110084 — Predictive Biomarker (PRD): PDE11A mRNA
Genes: PDE11A
Study 20110084 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 20110084 — Predictive Biomarker (PRD): GRIK4 mRNA
Genes: GRIK4; GRIK
Study 20110084 — Predictive Biomarker (PRD): 5HTT
Genes: SLC6A4; 5-HTT; SERT1
Study 30012187 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 30012187 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 24361739 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 17442998 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 16082603 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 10633886 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 10633886 — Surrogate Endpoint (SUR): Probing pocket depth
Study 1663053 — Surrogate Endpoint (SUR): Serum calcium
Study 27023825 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 7623991 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25824327 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 25824327 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 1550223 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 23803591 — Surrogate Endpoint (SUR): Blood pressure
Study 10996232 — Predictive Biomarker (PRD): TYMP mRNA
Genes: TYMP; ECGF1
Study 10996232 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 28585182 — Safety Biomarker (SAF): Urinary total protein
Study 20131302 — Surrogate Endpoint (SUR): Hematologic response
Study 16365061 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 12860366 — Predictive Biomarker (PRD): TYR mRNA
Genes: TYR
Study 9058684 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 25917060 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25917060 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25917060 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 25917060 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 10523461 — Surrogate Endpoint (SUR): Blood pressure
Study 31977825 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 26026604 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25682570 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 25682570 — Safety Biomarker (SAF): BDNF
Study 16368299 — Surrogate Endpoint (SUR): Blood pressure
Study 3929553 — Surrogate Endpoint (SUR): Blood pressure
Study 31790604 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31790604 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 27721227 — Surrogate Endpoint (SUR): Serum creatinine
Study 12925455 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 1449918 — Surrogate Endpoint (SUR): Blood pressure
Study 21975350 — Predictive Biomarker (PRD): CYP2A6 mRNA
Genes: CYP2A6; CYP2A3
Study 25670917 — Surrogate Endpoint (SUR): Blood pressure
Study 25119853 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25119853 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19262229 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 11576953 — Surrogate Endpoint (SUR): Blood pressure
Study 11576953 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11576953 — Surrogate Endpoint (SUR): Serum creatinine
Study 11576953 — Surrogate Endpoint (SUR): Serum potassium
Study 21991729 — Surrogate Endpoint (SUR): Blood pressure
Study 15641874 — Surrogate Endpoint (SUR): Blood pressure
Study 9080920 — Surrogate Endpoint (SUR): Blood pressure
Study 30919549 — Surrogate Endpoint (SUR): Blood pressure
Study 20816118 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18947338 — Predictive Biomarker (PRD): PGP mRNA
Genes: PGP
Study 15939064 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 1955196 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 25424602 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 25424602 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25424602 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15005733 — Safety Biomarker (SAF): Interleukin 12
Study 31855297 — Surrogate Endpoint (SUR): Blood pressure
Study 26477278 — Predictive Biomarker (PRD): MOXD1 mRNA
Genes: MOXD1; MOX; UNQ2493/PRO5780
Study 23444134 — Predictive Biomarker (PRD): BMP2 mRNA
Genes: BMP2; BMP2A
Study 21568746 — Predictive Biomarker (PRD): TCHH mRNA
Genes: TCHH; THH; THL; TRHY
Study 21985500 — Surrogate Endpoint (SUR): Blood pressure
Study 15690201 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11755749 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 28596023 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28596023 — Surrogate Endpoint (SUR): Serum triglycerides
Study 25939604 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 25939604 — Surrogate Endpoint (SUR): Bone mineral density
Study 17014006 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 17014006 — Pharmacodynamic Biomarker (PDY): T-lymphocyte activation antigen CD86
Genes: CD86; CD28LG2
Study 17014006 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 17014006 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17014006 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17014006 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 17014006 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11317165 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11317165 — Surrogate Endpoint (SUR): Blood pressure
Study 30025470 — Surrogate Endpoint (SUR): Blood pressure
Study 19066295 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11890163 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 21812263 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21812263 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21812263 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 19442784 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 15468351 — Safety Biomarker (SAF): HLA-DRB1
Genes: HLA-DR1B
Study 23297772 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 20492045 — Surrogate Endpoint (SUR): Blood pressure
Study 15922478 — Monitoring Biomarker (MOI): HBV DNA
Study 8677192 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 1854252 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 28482106 — Predictive Biomarker (PRD): MMD mRNA
Genes: MMD; PAQR11
Study 26209003 — Surrogate Endpoint (SUR): Blood pressure
Study 22421631 — Surrogate Endpoint (SUR): Blood pressure
Study 28704126 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 27228433 — Surrogate Endpoint (SUR): Blood pressure
Study 24533697 — Surrogate Endpoint (SUR): Blood pressure
Study 24533697 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30683061 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30683061 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 28424871 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 18834464 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18834464 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 18834464 — Predictive Biomarker (PRD): TPR mRNA
Genes: TPR
Study 18834464 — Surrogate Endpoint (SUR): Blood pressure
Study 8793416 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12933402 — Surrogate Endpoint (SUR): Blood pressure
Study 11103227 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 1728202 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 9951784 — Surrogate Endpoint (SUR): Bone mineral density
Study 20951147 — Surrogate Endpoint (SUR): Bone mineral density
Study 20951147 — Surrogate Endpoint (SUR): Blood pressure
Study 20562702 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20562702 — Surrogate Endpoint (SUR): Serum methemoglobin
Study 11925355 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 3075410 — Surrogate Endpoint (SUR): Blood pressure
Study 3075410 — Surrogate Endpoint (SUR): Serum potassium
Study 3075410 — Surrogate Endpoint (SUR): Serum uric acid
Study 31048415 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25416486 — Safety Biomarker (SAF): Aminopeptidase N
Genes: ANPEP; APN; CD13; PEPN
Study 19858233 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 19858233 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19858233 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 19858233 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17885562 — Surrogate Endpoint (SUR): Blood pressure
Study 24429201 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24815851 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11994377 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22428493 — Surrogate Endpoint (SUR): Blood pressure
Study 2953380 — Surrogate Endpoint (SUR): Blood pressure
Study 15503832 — Predictive Biomarker (PRD): UBXN11 mRNA
Genes: UBXN11; SOC; UBXD5; PP2243
Study 11240116 — Predictive Biomarker (PRD): PCSK7 mRNA
Genes: PCSK7; LPC; PC7; PC8; SPC7
Study 25116277 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 22884766 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 20413736 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20413736 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1743759 — Surrogate Endpoint (SUR): Blood pressure
Study 20216318 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28537012 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 25514619 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11396234 — Predictive Biomarker (PRD): REG3A mRNA
Genes: REG3A; HIP; PAP; PAP1
Study 9506661 — Safety Biomarker (SAF): MTHFR
Study 8794413 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7270561 — Surrogate Endpoint (SUR): Blood pressure
Study 21068008 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15468020 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 11441198 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1562096 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1562096 — Surrogate Endpoint (SUR): Blood pressure
Study 24531833 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 17564290 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12322819 — Surrogate Endpoint (SUR): Blood pressure
Study 7106840 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 11603100 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 9587722 — Surrogate Endpoint (SUR): Blood pressure
Study 28993388 — Surrogate Endpoint (SUR): Blood pressure
Study 12076867 — Surrogate Endpoint (SUR): Bone mineral density
Study 29217455 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 12584786 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12584786 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 12584786 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25039675 — Surrogate Endpoint (SUR): Blood pressure
Study 16033861 — Predictive Biomarker (PRD): SLC12A3 mRNA
Genes: SLC12A3; NCC; TSC
Study 31398065 — Predictive Biomarker (PRD): COTL1 mRNA
Genes: COTL1; CLP
Study 16968106 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16968106 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 3090830 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 1378147 — Surrogate Endpoint (SUR): Blood pressure
Study 31059641 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 28578601 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 26781417 — Safety Biomarker (SAF): Reactive oxygen species
Study 16291984 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 11889322 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 28763898 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28763898 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21591581 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 17389264 — Surrogate Endpoint (SUR): Blood pressure
Study 12018715 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16243716 — Monitoring Biomarker (MOI): Tissue transglutaminase
Genes: TGM2
Study 2215254 — Surrogate Endpoint (SUR): Plasma phenylalanine
Study 31842259 — Surrogate Endpoint (SUR): Blood pressure
Study 27473440 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 27473440 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 2142756 — Predictive Biomarker (PRD): PF4 mRNA
Genes: PF4; CXCL4; SCYB4
Study 2142756 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 29169877 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 24445723 — Surrogate Endpoint (SUR): Blood pressure
Study 22370535 — Predictive Biomarker (PRD): PLK1 mRNA
Genes: PLK1; PLK
Study 23181618 — Surrogate Endpoint (SUR): Blood pressure
Study 20859679 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 16784898 — Surrogate Endpoint (SUR): Bone mineral density
Study 11888949 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 26374825 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 26374825 — Predictive Biomarker (PRD): LDLR mRNA
Genes: LDLR
Study 26374825 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12929752 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12929752 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30445008 — Surrogate Endpoint (SUR): Bone mineral density
Study 21160226 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 15587094 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11522968 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 23759267 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24118860 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15802769 — Surrogate Endpoint (SUR): Bone mineral density
Study 6123837 — Surrogate Endpoint (SUR): Serum creatinine
Study 840125 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 29440016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24447343 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 24447343 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24447343 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 24447343 — Safety Biomarker (SAF): Platelet to lymphocyte
Study 24447343 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 17576071 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 11952432 — Surrogate Endpoint (SUR): Blood pressure
Study 9615498 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2649022 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23296464 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 7930473 — Monitoring Biomarker (MOI): HBV DNA
Study 25505230 — Predictive Biomarker (PRD): POLE mRNA
Genes: POLE; POLE1
Study 24713545 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 20151839 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 15896918 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 3932499 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 29543938 — Predictive Biomarker (PRD): ADAM17 mRNA
Genes: ADAM17; CSVP; TACE
Study 12389268 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29898171 — Predictive Biomarker (PRD): LSS mRNA
Genes: LSS; OSC
Study 22332827 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 20688574 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 15642074 — Surrogate Endpoint (SUR): Blood pressure
Study 7755658 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 7755658 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 7755658 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31162140 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 25606478 — Surrogate Endpoint (SUR): Blood pressure
Study 23835693 — Surrogate Endpoint (SUR): Blood pressure
Study 28246005 — Predictive Biomarker (PRD): GLS mRNA
Genes: GLS; GLS1; KIAA0838
Study 20553856 — Predictive Biomarker (PRD): ABR mRNA
Genes: ABR
Study 10812530 — Safety Biomarker (SAF): DRD2
Study 16181237 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 10073874 — Surrogate Endpoint (SUR): Blood pressure
Study 31034640 — Surrogate Endpoint (SUR): Bone mineral density
Study 26930244 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22702540 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15070956 — Surrogate Endpoint (SUR): Blood pressure
Study 30905725 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 26001837 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 9403805 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 12727577 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31564118 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11174383 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11174383 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11174383 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 28642082 — Surrogate Endpoint (SUR): Serum triglycerides
Study 28642082 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18258620 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 18258620 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14562857 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6097377 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30665383 — Predictive Biomarker (PRD): Glutamate carboxypeptidase II
Genes: FOLH1; FOLH; NAALAD1; PSM; PSMA; GIG27
Study 27127325 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27127325 — Surrogate Endpoint (SUR): Probing pocket depth
Study 25444588 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 21956486 — Surrogate Endpoint (SUR): Blood pressure
Study 17313701 — Predictive Biomarker (PRD): PPA1 mRNA
Genes: PPA1; IOPPP; PP
Study 31837640 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 31837640 — Safety Biomarker (SAF): BDNF
Study 30232789 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 23781882 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 23781882 — Safety Biomarker (SAF): BDNF
Study 8785393 — Surrogate Endpoint (SUR): Blood pressure