TrialPanorama/TrialPanorama-database huggingface dataset:
Study 12823158 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 19847430 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 19847430 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15259393 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 10064007 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 22108152 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 22108152 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22108152 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7908164 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7908164 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 7908164 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 23731042 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 22648373 — Predictive Biomarker (PRD): CHRNA5 mRNA
Genes: CHRNA5; NACHRA5
Study 22648373 — Predictive Biomarker (PRD): CHRNA3 mRNA
Genes: CHRNA3; NACHRA3
Study 22648373 — Predictive Biomarker (PRD): CHRNB4 mRNA
Genes: CHRNB4
Study 29705216 — Surrogate Endpoint (SUR): Blood pressure
Study 27751729 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27751729 — Predictive Biomarker (PRD): VHL mRNA
Genes: VHL
Study 27751729 — Predictive Biomarker (PRD): MAGI1 mRNA
Genes: MAGI1; AIP3; BAIAP1; BAP1; TNRC19
Study 27751729 — Predictive Biomarker (PRD): KDM5C mRNA
Genes: KDM5C; DXS1272E; JARID1C; SMCX; XE169
Study 27751729 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 27751729 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25673981 — Surrogate Endpoint (SUR): Blood pressure
Study 21334433 — Surrogate Endpoint (SUR): Serum creatinine
Study 8753109 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 1864255 — Surrogate Endpoint (SUR): Blood pressure
Study 6612689 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 6612689 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25308628 — Surrogate Endpoint (SUR): Blood pressure
Study 15340535 — Monitoring Biomarker (MOI): HBV DNA
Study 21641002 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 21641002 — Safety Biomarker (SAF): BDNF
Study 29766636 — Surrogate Endpoint (SUR): Blood pressure
Study 25056511 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 22252107 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16329018 — Surrogate Endpoint (SUR): Blood pressure
Study 7768667 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 7768667 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 15802964 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12877822 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 7486099 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31488342 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 22100822 — Surrogate Endpoint (SUR): Blood pressure
Study 19223653 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 15163089 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29304731 — Predictive Biomarker (PRD): SLC10A2 mRNA
Genes: SLC10A2; ASBT; ISBT; NTCP2
Study 25081901 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 18752510 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 15883419 — Surrogate Endpoint (SUR): Blood pressure
Study 19016257 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 19016257 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 12945880 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 12945880 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 11109978 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 11109978 — Surrogate Endpoint (SUR): Bone mineral density
Study 8924135 — Surrogate Endpoint (SUR): Serum potassium
Study 28390807 — Predictive Biomarker (PRD): NOS2 mRNA
Genes: NOS2; NOS2A
Study 26209543 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21989412 — Predictive Biomarker (PRD): TERT mRNA
Genes: TERT; EST2; TCS1; TRT
Study 19833274 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17074108 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC6A4 mRNA
Genes: SLC6A4; HTT; SERT
Study 15001263 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 31965179 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29887998 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 22249153 — Surrogate Endpoint (SUR): Blood pressure
Study 17767071 — Predictive Biomarker (PRD): PLAT mRNA
Genes: PLAT
Study 17767071 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 17767071 — Surrogate Endpoint (SUR): Blood pressure
Study 2901018 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 31865790 — Surrogate Endpoint (SUR): Blood pressure
Study 30009543 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30009543 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 19046178 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 6313029 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 14608267 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 30709714 — Surrogate Endpoint (SUR): Blood pressure
Study 30555484 — Predictive Biomarker (PRD): ENTPD1 mRNA
Genes: ENTPD1; CD39
Study 30555484 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16220067 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 16220067 — Surrogate Endpoint (SUR): Serum creatinine
Study 10363631 — Surrogate Endpoint (SUR): Blood pressure
Study 8618812 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 8618812 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30797014 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19406737 — Surrogate Endpoint (SUR): Blood pressure
Study 16778338 — Surrogate Endpoint (SUR): Blood pressure
Study 22486272 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 17639992 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2530507 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 2530507 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 21091792 — Predictive Biomarker (PRD): SLA mRNA
Genes: SLA; SLAP; SLAP1
Study 17208639 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 14871913 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28398597 — Predictive Biomarker (PRD): CCR7 mRNA
Genes: CCR7; CMKBR7; EBI1; EVI1
Study 23167508 — Surrogate Endpoint (SUR): Serum creatinine
Study 18079616 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 18079616 — Predictive Biomarker (PRD): FLT3 mRNA
Genes: FLT3; CD135; FLK2; STK1
Study 18079616 — Predictive Biomarker (PRD): CEBPA mRNA
Genes: CEBPA; CEBP
Study 18079616 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 16432953 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 16432953 — Surrogate Endpoint (SUR): Serum calcium
Study 10755496 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 1413198 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 28560503 — Surrogate Endpoint (SUR): Blood pressure
Study 25044127 — Predictive Biomarker (PRD): SLC2A9 mRNA
Genes: SLC2A9; GLUT9
Study 25044127 — Surrogate Endpoint (SUR): Serum uric acid
Study 6151741 — Surrogate Endpoint (SUR): Blood pressure
Study 21958882 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 9165656 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 8335427 — Surrogate Endpoint (SUR): Blood pressure
Study 8335427 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27514445 — Predictive Biomarker (PRD): ACP3 mRNA
Genes: ACP3; ACPP
Study 22703865 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19727071 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 22592761 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 19853678 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 25052724 — Surrogate Endpoint (SUR): Blood pressure
Study 25052724 — Surrogate Endpoint (SUR): Serum potassium
Study 19421321 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 19421321 — Surrogate Endpoint (SUR): Serum creatinine
Study 15068500 — Surrogate Endpoint (SUR): Serum triglycerides
Study 9781971 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21466595 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 21466595 — Surrogate Endpoint (SUR): Bone mineral density
Study 12627187 — Safety Biomarker (SAF): Reactive oxygen species
Study 12627187 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 3890497 — Predictive Biomarker (PRD): CAMP mRNA
Genes: CAMP; CAP18; FALL39; HSD26
Study 1706024 — Surrogate Endpoint (SUR): Blood pressure
Study 19024521 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 9523249 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 7661476 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 2547680 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2547680 — Surrogate Endpoint (SUR): Blood pressure
Study 30599063 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30599063 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10023943 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31542451 — Predictive Biomarker (PRD): AHR mRNA
Genes: AHR; BHLHE76
Study 21795740 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21795740 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21795740 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 21795740 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15003429 — Predictive Biomarker (PRD); Safety Biomarker (SAF): STAR mRNA
Genes: STAR; STARD1
Study 24752130 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 8998252 — Surrogate Endpoint (SUR): Blood pressure
Study 21443601 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 3355578 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25381995 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 19568710 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19568710 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 19568710 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19568710 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 16948779 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 21847649 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 1984187 — Surrogate Endpoint (SUR): Blood pressure
Study 29214015 — Surrogate Endpoint (SUR): Blood pressure
Study 25692608 — Predictive Biomarker (PRD): AMPH mRNA
Genes: AMPH; AMPH1
Study 15082131 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 11853276 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8151910 — Predictive Biomarker (PRD): TOB1 mRNA
Genes: TOB1; TOB; TROB1
Study 31812339 — Predictive Biomarker (PRD): TERF1 mRNA
Genes: TERF1; PIN2; TRBF1; TRF; TRF1
Study 31812339 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 3902676 — Surrogate Endpoint (SUR): Blood pressure
Study 19573053 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 12372925 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 31662381 — Surrogate Endpoint (SUR): Blood pressure
Study 24163324 — Surrogate Endpoint (SUR): Serum calcium
Study 25440634 — Predictive Biomarker (PRD): MEA1 mRNA
Genes: MEA1; MEA
Study 21300514 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 19108379 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10517718 — Surrogate Endpoint (SUR): Blood pressure
Study 27616885 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27616885 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17717913 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17717913 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 14996523 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12548209 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 10368355 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10368355 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 10368355 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 2050169 — Surrogate Endpoint (SUR): Blood pressure
Study 31345267 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26402148 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 28712537 — Predictive Biomarker (PRD): RPE65 mRNA
Genes: RPE65
Study 678886 — Surrogate Endpoint (SUR): Blood pressure
Study 31721907 — Surrogate Endpoint (SUR): Blood pressure
Study 1701715 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 24280463 — Surrogate Endpoint (SUR): Blood pressure
Study 24280463 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 16786214 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 6137325 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6137325 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6137325 — Surrogate Endpoint (SUR): Blood pressure
Study 26187260 — Surrogate Endpoint (SUR): Hemagglutination inhibition antibody
Study 18641709 — Surrogate Endpoint (SUR): Plasma ammonia
Study 9326125 — Surrogate Endpoint (SUR): Blood pressure
Study 18940656 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 1677502 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 1677502 — Surrogate Endpoint (SUR): Serum creatinine
Study 27987585 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 11310903 — Surrogate Endpoint (SUR): Serum intact parathyroid hormone
Study 11310903 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 16205886 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 12415535 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 12138805 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7857409 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 12680866 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 8965861 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 1671113 — Surrogate Endpoint (SUR): Blood pressure
Study 30122196 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 24618208 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20148911 — Surrogate Endpoint (SUR): Bone mineral density
Study 9164990 — Safety Biomarker (SAF): Reactive oxygen species
Study 2504855 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8803857 — Surrogate Endpoint (SUR): Blood pressure
Study 15167308 — Surrogate Endpoint (SUR): Bone mineral density
Study 12501904 — Surrogate Endpoint (SUR): Blood pressure
Study 21782375 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 21782375 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24665827 — Predictive Biomarker (PRD): PF4 mRNA
Genes: PF4; CXCL4; SCYB4
Study 22311204 — Pharmacodynamic Biomarker (PDY): Error related negativity
Study 21088095 — Surrogate Endpoint (SUR): Blood pressure
Study 12466730 — Surrogate Endpoint (SUR): Blood pressure
Study 2157982 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 30660472 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23351820 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 23351820 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 14726370 — Surrogate Endpoint (SUR): Blood pressure
Study 8989011 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 7966066 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29274242 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29274242 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 26434404 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19083400 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19083400 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 19083400 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 12934311 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31072274 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 28387882 — Safety Biomarker (SAF): Hyaluronic acid
Study 11210070 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 31525271 — Surrogate Endpoint (SUR): Blood pressure
Study 24534756 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 20431041 — Predictive Biomarker (PRD): PRKD1 mRNA
Genes: PRKD1; PKD; PKD1; PRKCM
Study 20431041 — Surrogate Endpoint (SUR): Total kidney volume
Study 12499817 — Surrogate Endpoint (SUR): Serum creatinine
Study 7540062 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7540062 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 2183866 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 7981574 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 19464709 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19464709 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19464709 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15281431 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 27633173 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 27633173 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 22155931 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 22155931 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 22155931 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 22155931 — Pharmacodynamic Biomarker (PDY): Stromal cell-derived factor 1
Genes: CXCL12; SDF1; SDF1A; SDF1B
Study 27258301 — Surrogate Endpoint (SUR): Blood pressure
Study 19295332 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7955553 — Predictive Biomarker (PRD): NPY mRNA
Genes: NPY
Study 7955553 — Surrogate Endpoint (SUR): Blood pressure
Study 31796259 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 11844656 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11844656 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11844656 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1673816 — Surrogate Endpoint (SUR): Blood pressure
Study 31765988 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 28193301 — Predictive Biomarker (PRD): CA4 mRNA
Genes: CA4
Study 15117912 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15117912 — Surrogate Endpoint (SUR): Blood pressure
Study 11606175 — Surrogate Endpoint (SUR): Serum creatinine
Study 11606175 — Surrogate Endpoint (SUR): Blood pressure
Study 22607100 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22607100 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 22607100 — Surrogate Endpoint (SUR): Serum creatinine
Study 18534016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26285807 — Surrogate Endpoint (SUR): Probing pocket depth
Study 21827635 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 21827635 — Predictive Biomarker (PRD): MAPK3 mRNA
Genes: MAPK3; ERK1; PRKM3
Study 21827635 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 21827635 — Safety Biomarker (SAF): Reactive oxygen species
Study 21827635 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2