TrialPanorama/TrialPanorama-database huggingface dataset:
Study 27401788 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 27401788 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27401788 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 17290160 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15326072 — Surrogate Endpoint (SUR): Blood pressure
Study 25880483 — Surrogate Endpoint (SUR): Bone mineral density
Study 11174341 — Surrogate Endpoint (SUR): Blood pressure
Study 15521079 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 29992831 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 29020293 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23427000 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 16925467 — Surrogate Endpoint (SUR): Blood pressure
Study 9136940 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 3720035 — Surrogate Endpoint (SUR): Serum creatinine
Study 3720035 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 25004111 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 25004111 — Predictive Biomarker (PRD): Lymphocyte activation antigen CD30
Genes: TNFRSF8; CD30; D1S166E
Study 25004111 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 25004111 — Predictive Biomarker (PRD): CXCR3 mRNA
Genes: CXCR3; GPR9
Study 25004111 — Predictive Biomarker (PRD): CCR4 mRNA
Genes: CCR4; CMKBR4
Study 25004111 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 25004111 — Safety Biomarker (SAF): Cytotoxic T-lymphocyte protein 4
Genes: CTLA4; CD152
Study 25004111 — Predictive Biomarker (PRD): ICOS mRNA
Genes: ICOS; AILIM
Study 22730857 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 7762912 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 7762912 — Surrogate Endpoint (SUR): Blood pressure
Study 2407002 — Surrogate Endpoint (SUR): Serum creatinine
Study 31769585 — Safety Biomarker (SAF): Hyaluronic acid
Study 26914484 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 26914484 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26914484 — Surrogate Endpoint (SUR): Blood pressure
Study 18505180 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 14578869 — Safety Biomarker (SAF): BCHE
Genes: E1
Study 10714552 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 10714552 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 1376841 — Surrogate Endpoint (SUR): Blood pressure
Study 31619305 — Predictive Biomarker (PRD): PPARG mRNA
Genes: PPARG; NR1C3
Study 31619305 — Predictive Biomarker (PRD): PCSK1 mRNA
Genes: PCSK1; NEC1
Study 15876828 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 25559915 — Surrogate Endpoint (SUR): Blood pressure
Study 25559915 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25559915 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 22475046 — Predictive Biomarker (PRD): CCND1 mRNA
Genes: CCND1; BCL1; PRAD1
Study 22475046 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 15133425 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15133425 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2679938 — Surrogate Endpoint (SUR): Blood pressure
Study 3596789 — Surrogate Endpoint (SUR): Blood pressure
Study 26320194 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 26320194 — Safety Biomarker (SAF): DRD2
Study 19811362 — Surrogate Endpoint (SUR): Blood pressure
Study 21442808 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 9404589 — Surrogate Endpoint (SUR): Blood pressure
Study 3120167 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 29604403 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 29604403 — Surrogate Endpoint (SUR): Blood pressure
Study 27696440 — Predictive Biomarker (PRD): RALA mRNA
Genes: RALA; RAL
Study 27696440 — Predictive Biomarker (PRD): SLC35A2 mRNA
Genes: SLC35A2; UGALT; UGT; UGTL
Study 22571342 — Predictive Biomarker (PRD): DNMT1 mRNA
Genes: DNMT1; AIM; CXXC9; DNMT
Study 16133554 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 10540010 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 7887757 — Surrogate Endpoint (SUR): Blood pressure
Study 7887757 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1977258 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 1977258 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 26913398 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23761178 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23761178 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24942912 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 24167223 — Predictive Biomarker (PRD): FASN mRNA
Genes: FASN; FAS
Study 24167223 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 24167223 — Predictive Biomarker (PRD): PDK4 mRNA
Genes: PDK4; PDHK4
Study 24167223 — Predictive Biomarker (PRD): IRS2 mRNA
Genes: IRS2
Study 24167223 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 7593457 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 17371337 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21421493 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 29329923 — Predictive Biomarker (PRD): RBP4 mRNA
Genes: RBP4; PRO2222
Study 18227529 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 18227529 — Predictive Biomarker (PRD): Hormone receptor
Study 1475616 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 1475616 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 1475616 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 6202898 — Predictive Biomarker (PRD): BLM mRNA
Genes: BLM; RECQ2; RECQL3
Study 27473050 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 19144653 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9475647 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 31116274 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 31286397 — Surrogate Endpoint (SUR): Blood pressure
Study 19543958 — Predictive Biomarker (PRD): Forkhead box protein P3
Genes: FOXP3; IPEX; JM2
Study 19543958 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 17221216 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 17221216 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12582020 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 10918204 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 9114905 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9114905 — Surrogate Endpoint (SUR): Blood pressure
Study 27206122 — Predictive Biomarker (PRD): RASA1 mRNA
Genes: RASA1; GAP; RASA
Study 22296837 — Surrogate Endpoint (SUR): Blood pressure
Study 20824720 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 20824720 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 11094036 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 1618242 — Surrogate Endpoint (SUR): Blood pressure
Study 1618242 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21996087 — Predictive Biomarker (PRD): DNA excision repair protein ERCC-1
Genes: ERCC1
Study 21996087 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 21996087 — Predictive Biomarker (PRD): Tubulin beta-3 chain
Genes: TUBB3; TUBB4
Study 21996087 — Predictive Biomarker (PRD): Ribonucleoside-diphosphate reductase large subunit
Genes: RRM1; RR1
Study 23471413 — Surrogate Endpoint (SUR): Blood pressure
Study 9585287 — Surrogate Endpoint (SUR): Blood pressure
Study 2543337 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 21624774 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 21624774 — Predictive Biomarker (PRD): LEP mRNA
Genes: LEP; OB; OBS
Study 7870908 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 20668051 — Surrogate Endpoint (SUR): Blood pressure
Study 18346640 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 18346640 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18346640 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 18346640 — Predictive Biomarker (PRD): FOXP3 mRNA
Genes: FOXP3; IPEX; JM2
Study 18346640 — Surrogate Endpoint (SUR): Serum creatinine
Study 9557918 — Surrogate Endpoint (SUR): Blood pressure
Study 24308723 — Surrogate Endpoint (SUR): Serum testosterone
Study 10558962 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 22565002 — Predictive Biomarker (PRD): Hormone receptor
Study 10030391 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 10030391 — Predictive Biomarker (PRD): PLTP mRNA
Genes: PLTP
Study 7541269 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 2188165 — Surrogate Endpoint (SUR): Blood pressure
Study 24218432 — Surrogate Endpoint (SUR): Blood pressure
Study 15465619 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 26681730 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 26681730 — Surrogate Endpoint (SUR): Blood pressure
Study 26681730 — Surrogate Endpoint (SUR): Total kidney volume
Study 17236796 — Predictive Biomarker (PRD): CR1 mRNA
Genes: CR1; C3BR
Study 17236796 — Predictive Biomarker (PRD): CR2 mRNA
Genes: CR2; C3DR
Study 9222303 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 3038422 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3038422 — Surrogate Endpoint (SUR): Blood pressure
Study 22907057 — Surrogate Endpoint (SUR): Blood pressure
Study 19876001 — Surrogate Endpoint (SUR): Blood pressure
Study 17400660 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 17400660 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 12083753 — Predictive Biomarker (PRD): CAST mRNA
Genes: CAST
Study 2454373 — Surrogate Endpoint (SUR): Blood pressure
Study 28337872 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26159013 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 26159013 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23200261 — Surrogate Endpoint (SUR): Blood pressure
Study 18048590 — Predictive Biomarker (PRD): AKT1 mRNA
Genes: AKT1; PKB; RAC
Study 18048590 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12548303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12548303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12548303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22643537 — Predictive Biomarker (PRD): KIT
Genes: CD117; SCFR; C-Kit
Study 9861379 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 374176 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16371674 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 7920454 — Surrogate Endpoint (SUR): Blood pressure
Study 26069034 — Predictive Biomarker (PRD): CYP2A6 mRNA
Genes: CYP2A6; CYP2A3
Study 26069034 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 25261324 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 25261324 — Surrogate Endpoint (SUR): Forced vital capacity
Study 20800244 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 16825135 — Surrogate Endpoint (SUR): Blood pressure
Study 10828704 — Surrogate Endpoint (SUR): Blood pressure
Study 31585495 — Predictive Biomarker (PRD): LARS1 mRNA
Genes: LARS1; KIAA1352; LARS
Study 17907111 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 17907111 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17907111 — Surrogate Endpoint (SUR): Serum creatinine
Study 11929492 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 10422937 — Surrogate Endpoint (SUR): Blood pressure
Study 28376103 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 29383893 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 21208417 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 14715336 — Surrogate Endpoint (SUR): Blood pressure
Study 14715336 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2885946 — Surrogate Endpoint (SUR): Blood pressure
Study 26896734 — Surrogate Endpoint (SUR): Serum creatinine
Study 20334708 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 11921698 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30957284 — Safety Biomarker (SAF): miR-18a
Genes: MIR18A
Study 30957284 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-223
Genes: MIR223
Study 28066879 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28066879 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2031078 — Monitoring Biomarker (MOI): HBV DNA
Study 7171405 — Surrogate Endpoint (SUR): Blood pressure
Study 7278216 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31120957 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31120957 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 26717109 — Safety Biomarker (SAF): Cytochrome c
Study 24880443 — Surrogate Endpoint (SUR): Blood pressure
Study 22213436 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 22213436 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12004636 — Surrogate Endpoint (SUR): Blood pressure
Study 2523646 — Surrogate Endpoint (SUR): Blood pressure
Study 10850381 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 16088848 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 16088848 — Surrogate Endpoint (SUR): Blood pressure
Study 27743130 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 25613811 — Surrogate Endpoint (SUR): Blood pressure
Study 23941362 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 8922657 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 8922657 — Surrogate Endpoint (SUR): Serum calcium
Study 8922657 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 1372418 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28392176 — Predictive Biomarker (PRD): GAL3ST1 mRNA
Genes: GAL3ST1; CST
Study 11208823 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31727768 — Predictive Biomarker (PRD): Apoptosis regulator Bcl-2
Genes: BCL2
Study 22039193 — Surrogate Endpoint (SUR): Blood pressure
Study 17291932 — Surrogate Endpoint (SUR): Blood pressure
Study 17291932 — Surrogate Endpoint (SUR): Serum creatinine
Study 30537083 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30537083 — Surrogate Endpoint (SUR): Blood pressure
Study 28691132 — Predictive Biomarker (PRD): Hormone receptor
Study 25445556 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 23806773 — Surrogate Endpoint (SUR): Bone mineral density
Study 16888706 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11709314 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15247339 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 3076118 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21150717 — Predictive Biomarker (PRD): WT1 mRNA
Genes: WT1
Study 21150717 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 21150717 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HLA-A
Study 31241541 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31241541 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 31241541 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21878941 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21878941 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 15455650 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15455650 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 15455650 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11432629 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30509509 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6366248 — Surrogate Endpoint (SUR): Serum creatinine
Study 25550680 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 26147387 — Surrogate Endpoint (SUR): Blood pressure
Study 23683600 — Surrogate Endpoint (SUR): Bone mineral density
Study 22024489 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22024489 — Surrogate Endpoint (SUR): Blood pressure
Study 22024489 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22024489 — Predictive Biomarker (PRD): LDLR mRNA
Genes: LDLR
Study 18300863 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18300863 — Surrogate Endpoint (SUR): Blood pressure
Study 16284226 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 8272252 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 30982023 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 24718886 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 9627822 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 31207663 — Surrogate Endpoint (SUR): Blood pressure
Study 31207663 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27848196 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 21525259 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24665871 — Surrogate Endpoint (SUR): Probing pocket depth
Study 24665871 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23505301 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 23505301 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 2065035 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6127790 — Predictive Biomarker (PRD): PPA1 mRNA
Genes: PPA1; IOPPP; PP
Study 26082615 — Surrogate Endpoint (SUR): Blood pressure
Study 22522994 — Surrogate Endpoint (SUR): Blood pressure
Study 18449450 — Surrogate Endpoint (SUR): Serum creatinine
Study 10486676 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10486676 — Surrogate Endpoint (SUR): Blood pressure
Study 1565534 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 4084979 — Surrogate Endpoint (SUR): Blood pressure
Study 11976989 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10713863 — Safety Biomarker (SAF): Hyaluronic acid
Study 9988396 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 7771479 — Surrogate Endpoint (SUR): Blood pressure
Study 7771479 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15310939 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 797044 — Surrogate Endpoint (SUR): Blood pressure
Study 797044 — Surrogate Endpoint (SUR): Forced vital capacity
Study 26653621 — Surrogate Endpoint (SUR): Blood pressure
Study 11160951 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 8287887 — Predictive Biomarker (PRD): CPA1 mRNA
Genes: CPA1; CPA
Study 31529097 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 30519590 — Surrogate Endpoint (SUR): Blood pressure
Study 24126707 — Predictive Biomarker (PRD): OPRD1 mRNA
Genes: OPRD1; OPRD
Study 20831535 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 11309548 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 22301799 — Predictive Biomarker (PRD): ZFP36 mRNA
Genes: ZFP36; G0S24; NUP475; RNF162A; TIS11A; TTP
Study 2571061 — Surrogate Endpoint (SUR): Blood pressure
Study 25982993 — Predictive Biomarker (PRD): PARN mRNA
Genes: PARN; DAN
Study 15339677 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 8187315 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 12740260 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 31906840 — Surrogate Endpoint (SUR): Bone mineral density
Study 27956679 — Safety Biomarker (SAF): MTHFR
Study 22371302 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 18801887 — Surrogate Endpoint (SUR): Blood pressure
Study 25994819 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 26613788 — Surrogate Endpoint (SUR): Bone mineral density
Study 6137236 — Predictive Biomarker (PRD): PARN mRNA
Genes: PARN; DAN
Study 24881631 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 2782271 — Surrogate Endpoint (SUR): Blood pressure
Study 10438343 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10438343 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 1981880 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 25358636 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 15042003 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1