TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23208880 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21802442 — Surrogate Endpoint (SUR): Blood pressure
Study 17051359 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 9135354 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 3583091 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 19660594 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 19660594 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19660594 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11116238 — Surrogate Endpoint (SUR): Blood pressure
Study 31393573 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18415455 — Surrogate Endpoint (SUR): Blood pressure
Study 8467286 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 27310942 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 18256325 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 2877386 — Surrogate Endpoint (SUR): Blood pressure
Study 12511360 — Surrogate Endpoint (SUR): Blood pressure
Study 19228659 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 18034788 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 12418614 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 15629602 — Predictive Biomarker (PRD): POR mRNA
Genes: POR; CYPOR
Study 27003301 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 25106008 — Predictive Biomarker (PRD): RB1
Genes: RB; PPP1R130
Study 10995594 — Surrogate Endpoint (SUR): Blood pressure
Study 9315539 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9315539 — Surrogate Endpoint (SUR): Blood pressure
Study 24067320 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27366506 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 21128258 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1649838 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 27899456 — Predictive Biomarker (PRD): SERPINA6 mRNA
Genes: SERPINA6; CBG
Study 24670413 — Surrogate Endpoint (SUR): Blood pressure
Study 18687174 — Surrogate Endpoint (SUR): Blood pressure
Study 10102070 — Predictive Biomarker (PRD): FGFR3 mRNA
Genes: FGFR3; JTK4
Study 10102070 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor receptor
Study 2225702 — Surrogate Endpoint (SUR): Blood pressure
Study 334221 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 19934030 — Safety Biomarker (SAF): Interleukin 12
Study 18940534 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31721495 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 15960271 — Surrogate Endpoint (SUR): Blood pressure
Study 9704689 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9704689 — Surrogate Endpoint (SUR): Blood pressure
Study 28888516 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1971199 — Surrogate Endpoint (SUR): Blood pressure
Study 19662024 — Surrogate Endpoint (SUR): Blood pressure
Study 2508049 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 7700076 — Surrogate Endpoint (SUR): Blood pressure
Study 25699349 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25822648 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 25822648 — Safety Biomarker (SAF): Hyaluronic acid
Study 15288592 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15288592 — Surrogate Endpoint (SUR): Serum triglycerides
Study 9441096 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26581842 — Surrogate Endpoint (SUR): Blood pressure
Study 18305085 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 18305085 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 10875787 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 9083231 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9083231 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 9083231 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9083231 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Interleukin 6 receptor alpha
Genes: IL6R
Study 9083231 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9083231 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 8239321 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18785254 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 27842163 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27842163 — Predictive Biomarker (PRD): RPE65 mRNA
Genes: RPE65
Study 27842163 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 20724937 — Surrogate Endpoint (SUR): Blood pressure
Study 9129047 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 7893592 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 7893592 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 25594427 — Predictive Biomarker (PRD): TRPV1 mRNA
Genes: TRPV1; VR1
Study 25594427 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 20176986 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20176986 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16766116 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 20538329 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 20538329 — Predictive Biomarker (PRD): CCR7 mRNA
Genes: CCR7; CMKBR7; EBI1; EVI1
Study 23926208 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23926208 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Interleukin 6 receptor alpha
Genes: IL6R
Study 23926208 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21878535 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Mucin-1
Genes: MUC1; PUM
Study 21878535 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19214676 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 28202033 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26387028 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26387028 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 3177228 — Surrogate Endpoint (SUR): Blood pressure
Study 30499685 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26887576 — Safety Biomarker (SAF): Hyaluronic acid
Study 21178616 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 29982805 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29138547 — Predictive Biomarker (PRD): LAMA1 mRNA
Genes: LAMA1; LAMA
Study 19416526 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19416526 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 19416526 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9681666 — Safety Biomarker (SAF): 51Cr-EDTA
Study 772425 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 772425 — Surrogate Endpoint (SUR): Blood pressure
Study 31734696 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 28544807 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28544807 — Surrogate Endpoint (SUR): Bone mineral density
Study 21305270 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21305270 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 16886588 — Surrogate Endpoint (SUR): Bone mineral density
Study 16886588 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 23828291 — Surrogate Endpoint (SUR): Bone mineral density
Study 14702440 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 11736869 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 23620935 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9834042 — Surrogate Endpoint (SUR): Blood pressure
Study 2685451 — Surrogate Endpoint (SUR): Blood pressure
Study 23500281 — Surrogate Endpoint (SUR): Blood pressure
Study 23500281 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1611155 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1611155 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30907198 — Surrogate Endpoint (SUR): Forced vital capacity
Study 28394002 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 23046851 — Surrogate Endpoint (SUR): Blood pressure
Study 19364887 — Predictive Biomarker (PRD): SLMAP mRNA
Genes: SLMAP; KIAA1601; SLAP; UNQ1847/PRO3577
Study 3593624 — Surrogate Endpoint (SUR): Blood pressure
Study 9590466 — Surrogate Endpoint (SUR): Blood pressure
Study 8072816 — Predictive Biomarker (PRD): DPT mRNA
Genes: DPT
Study 28209466 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 28754834 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20606093 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29858393 — Predictive Biomarker (PRD): LAMB2 mRNA
Genes: LAMB2; LAMS
Study 22640983 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 14678373 — Surrogate Endpoint (SUR): Blood pressure
Study 11743658 — Predictive Biomarker (PRD): BCL6 mRNA
Genes: BCL6; BCL5; LAZ3; ZBTB27; ZNF51
Study 11743658 — Predictive Biomarker (PRD): Apoptosis regulator Bcl-2
Genes: BCL2
Study 11743658 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 11743658 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 11743658 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 10628245 — Predictive Biomarker (PRD): KCNH2 mRNA
Genes: KCNH2; ERG; ERG1; HERG
Study 25423571 — Predictive Biomarker (PRD): SLC2A2 mRNA
Genes: SLC2A2; GLUT2
Study 25423571 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16112255 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 27538683 — Predictive Biomarker (PRD): TBC1D8 mRNA
Genes: TBC1D8; VRP
Study 16154479 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 2186304 — Predictive Biomarker (PRD): CBS mRNA
Genes: CBS
Study 26619553 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 26619553 — Surrogate Endpoint (SUR): Serum uric acid
Study 26619553 — Surrogate Endpoint (SUR): Serum creatinine
Study 22153519 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 29426359 — Surrogate Endpoint (SUR): Blood pressure
Study 18444130 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 18444130 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 9084068 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 8273571 — Predictive Biomarker (PRD): PIR mRNA
Genes: PIR
Study 26220093 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 21392067 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 17223873 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 15346824 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 15346824 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 11394510 — Predictive Biomarker (PRD): MVP mRNA
Genes: MVP; LRP
Study 22913893 — Surrogate Endpoint (SUR): Blood pressure
Study 29879143 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27379733 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 20801248 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 19179739 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 19179739 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 1463530 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29576535 — Safety Biomarker (SAF): Reactive oxygen species
Study 11976195 — Surrogate Endpoint (SUR): Blood pressure
Study 9473971 — Surrogate Endpoint (SUR): Blood pressure
Study 29278471 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 10591988 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 1657078 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26850307 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 12518931 — Surrogate Endpoint (SUR): Blood pressure
Study 7741289 — Surrogate Endpoint (SUR): Blood pressure
Study 25710925 — Predictive Biomarker (PRD): SLC25A20 mRNA
Genes: SLC25A20; CAC; CACT
Study 10647797 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 24886116 — Surrogate Endpoint (SUR): Blood pressure
Study 16907968 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16907968 — Surrogate Endpoint (SUR): Blood pressure
Study 8648396 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 1794947 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 20863759 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 20863759 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30205182 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 31455149 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 16913827 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12025521 — Surrogate Endpoint (SUR): Blood pressure
Study 2393014 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 24338736 — Predictive Biomarker (PRD): NOS1AP mRNA
Genes: NOS1AP; CAPON; KIAA0464
Study 19657792 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 12556688 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12556688 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 12556688 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 12556688 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 20646185 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12010906 — Surrogate Endpoint (SUR): Serum creatinine
Study 8826572 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 26547514 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 24823873 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 10452757 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 10452757 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 28187051 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31945496 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 31945496 — Safety Biomarker (SAF): Reactive oxygen species
Study 16914336 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 11358726 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 11358726 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 18077786 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12212206 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12212206 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3545116 — Surrogate Endpoint (SUR): Blood pressure
Study 23163982 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23163982 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 23163982 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 23163982 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 23163982 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20876317 — Pharmacodynamic Biomarker (PDY): Signal transducer and activator of transcription 3
Genes: STAT3; APRF
Study 16178642 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 10050702 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 2077498 — Surrogate Endpoint (SUR): Blood pressure
Study 28117242 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 23773380 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 14988471 — Surrogate Endpoint (SUR): Bone mineral density
Study 18632424 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18632424 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18632424 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10840172 — Surrogate Endpoint (SUR): Blood pressure
Study 9375951 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30074491 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 18219956 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12057725 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12057725 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27067612 — Surrogate Endpoint (SUR): Blood pressure
Study 23166441 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23166441 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19220959 — Predictive Biomarker (PRD): ASRGL1 mRNA
Genes: ASRGL1; ALP; CRASH
Study 17553207 — Surrogate Endpoint (SUR): Bone mineral density
Study 3028699 — Surrogate Endpoint (SUR): Blood pressure
Study 18237574 — Surrogate Endpoint (SUR): Blood pressure
Study 18237574 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2539762 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2539762 — Surrogate Endpoint (SUR): Blood pressure
Study 24068631 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24068631 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19151379 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 26106626 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26106626 — Safety Biomarker (SAF): Interleukin 1
Study 19964412 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 7871106 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 25473945 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 12619672 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 9255326 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 21736700 — Predictive Biomarker (PRD): EBF1 mRNA
Genes: EBF1; COE1; EBF
Study 20687982 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 16093575 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16093575 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16093575 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16093575 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 18090695 — Surrogate Endpoint (SUR): Blood pressure
Study 18070096 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 18070096 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18070096 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 14691666 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 14691666 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 14691666 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14691666 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31957251 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 31184015 — Safety Biomarker (SAF): Hyaluronic acid
Study 16618361 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 6662172 — Surrogate Endpoint (SUR): Forced vital capacity
Study 9576119 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9576119 — Surrogate Endpoint (SUR): Blood pressure
Study 28272227 — Safety Biomarker (SAF): Reactive oxygen species
Study 28272227 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28272227 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2