TrialPanorama/TrialPanorama-database huggingface dataset:
Study 26873498 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 17081540 — Surrogate Endpoint (SUR): Blood pressure
Study 31816038 — Surrogate Endpoint (SUR): Blood pressure
Study 12871402 — Surrogate Endpoint (SUR): Serum triglycerides
Study 11908577 — Predictive Biomarker (PRD): LIF mRNA
Genes: LIF; HILDA
Study 839327 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 31743617 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 31743617 — Predictive Biomarker (PRD): HDAC4 mRNA
Genes: HDAC4; KIAA0288
Study 31743617 — Predictive Biomarker (PRD): MEF2C mRNA
Genes: MEF2C
Study 31743617 — Predictive Biomarker (PRD): FST mRNA
Genes: FST
Study 24621355 — Surrogate Endpoint (SUR): Blood pressure
Study 15280147 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27859410 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12972442 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 2819522 — Surrogate Endpoint (SUR): Blood pressure
Study 16682309 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 14996470 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 14996470 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 3327930 — Surrogate Endpoint (SUR): Blood pressure
Study 15599642 — Safety Biomarker (SAF): Hyaluronic acid
Study 28865249 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 7589023 — Surrogate Endpoint (SUR): Blood pressure
Study 225750 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 24480113 — Surrogate Endpoint (SUR): Blood pressure
Study 22763473 — Surrogate Endpoint (SUR): Blood pressure
Study 17962596 — Surrogate Endpoint (SUR): Blood pressure
Study 1934003 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1934003 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12114041 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 12114041 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 12114041 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 12114041 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 10220224 — Predictive Biomarker (PRD): GRIN1 mRNA
Genes: GRIN1; NMDAR1
Study 10220224 — Predictive Biomarker (PRD): GRIN2A mRNA
Genes: GRIN2A; NMDAR2A
Study 2191584 — Surrogate Endpoint (SUR): Blood pressure
Study 381954 — Surrogate Endpoint (SUR): Serum uric acid
Study 24494790 — Surrogate Endpoint (SUR): Blood pressure
Study 27305912 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 20136764 — Surrogate Endpoint (SUR): Blood pressure
Study 12432838 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 9167559 — Surrogate Endpoint (SUR): Serum potassium
Study 8466725 — Surrogate Endpoint (SUR): Blood pressure
Study 29964324 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 7783099 — Surrogate Endpoint (SUR): Blood pressure
Study 7783099 — Surrogate Endpoint (SUR): Serum potassium
Study 18572029 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 10599715 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 10599715 — Surrogate Endpoint (SUR): Bone mineral density
Study 30805617 — Predictive Biomarker (PRD): FXYD1 mRNA
Genes: FXYD1; PLM
Study 17374660 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15098169 — Surrogate Endpoint (SUR): Blood pressure
Study 11216756 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 9798655 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7886971 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 26188380 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 20386359 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 20386359 — Predictive Biomarker (PRD): VKORC1 mRNA
Genes: VKORC1; VKOR; MSTP134; MSTP576; UNQ308/PRO351
Study 10808698 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 1599986 — Surrogate Endpoint (SUR): Blood pressure
Study 1746997 — Surrogate Endpoint (SUR): Serum potassium
Study 1746997 — Surrogate Endpoint (SUR): Blood pressure
Study 26656144 — Predictive Biomarker (PRD): IL1RL1 mRNA
Genes: IL1RL1; DER4; ST2; T1
Study 26656144 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 24288691 — Surrogate Endpoint (SUR): Blood pressure
Study 23017309 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23017309 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23017309 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17620054 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 11673342 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29077146 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26243579 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 23847491 — Pharmacodynamic Biomarker (PDY): Error related negativity
Study 23847491 — Surrogate Endpoint (SUR): Blood pressure
Study 19223284 — Surrogate Endpoint (SUR): Blood pressure
Study 29644962 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29644962 — Predictive Biomarker (PRD): TJP1 mRNA
Genes: TJP1; ZO1
Study 18505083 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 9257199 — Surrogate Endpoint (SUR): Blood pressure
Study 3706190 — Predictive Biomarker (PRD): PDXP mRNA
Genes: PDXP; CIN; PLP; PLPP
Study 26722670 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 22803768 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 22803768 — Surrogate Endpoint (SUR): Bone mineral density
Study 7875147 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 22753402 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 31725787 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31725787 — Surrogate Endpoint (SUR): Serum creatinine
Study 16386890 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 30673028 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 30442354 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 30442354 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 11788558 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 11788558 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 2576246 — Surrogate Endpoint (SUR): Blood pressure
Study 31520543 — Surrogate Endpoint (SUR): Probing pocket depth
Study 30204517 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 26083409 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26083409 — Predictive Biomarker (PRD): CCR7 mRNA
Genes: CCR7; CMKBR7; EBI1; EVI1
Study 26083409 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 19293261 — Surrogate Endpoint (SUR): Blood pressure
Study 12918546 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 1294196 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1294196 — Surrogate Endpoint (SUR): Blood pressure
Study 24483103 — Safety Biomarker (SAF): Hyaluronic acid
Study 24189463 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 24189463 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24189463 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8402803 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 8402803 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 27863807 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25009196 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 25009196 — Predictive Biomarker (PRD): KLRK1 mRNA
Genes: KLRK1; D12S2489E; NKG2D
Study 2101781 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28449709 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 21434338 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 21434338 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 21434338 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 9691229 — Surrogate Endpoint (SUR): Serum triglycerides
Study 7918062 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7918062 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 7918062 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 7918062 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 28196256 — Surrogate Endpoint (SUR): Blood pressure
Study 21159786 — Predictive Biomarker (PRD): C1QTNF9 mRNA
Genes: C1QTNF9; C1QTNF9A; UNQ6503/PRO21380
Study 21159786 — Predictive Biomarker (PRD): PPBP mRNA
Genes: PPBP; CTAP3; CXCL7; SCYB7; TGB1; THBGB1
Study 21159786 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31860959 — Predictive Biomarker (PRD): DNMT3A mRNA
Genes: DNMT3A
Study 31860959 — Predictive Biomarker (PRD): ZEB1 mRNA
Genes: ZEB1; AREB6; TCF8
Study 31860959 — Predictive Biomarker (PRD): MMP13 mRNA
Genes: MMP13
Study 31860959 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CTNNB1 mRNA
Genes: CTNNB1; CTNNB; OK/SW-cl.35; PRO2286
Study 31860959 — Safety Biomarker (SAF): miR-200c
Genes: MIR200C
Study 26716877 — Surrogate Endpoint (SUR): Blood pressure
Study 17351383 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16351772 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 11181473 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 30578714 — Predictive Biomarker (PRD): CDKN2A mRNA
Genes: CDKN2A; CDKN2; MTS1
Study 30578714 — Predictive Biomarker (PRD): NRAS mRNA
Genes: NRAS; HRAS1
Study 15641601 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20947098 — Predictive Biomarker (PRD): CXCL13 mRNA
Genes: CXCL13; BCA1; BLC; SCYB13
Study 20947098 — Predictive Biomarker (PRD): CCL17 mRNA
Genes: CCL17; SCYA17; TARC
Study 20947098 — Predictive Biomarker (PRD): CCL20 mRNA
Genes: CCL20; LARC; MIP3A; SCYA20
Study 25319074 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 10853298 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 8704111 — Surrogate Endpoint (SUR): Blood pressure
Study 1793331 — Surrogate Endpoint (SUR): Blood pressure
Study 25139539 — Predictive Biomarker (PRD): PDPN mRNA
Genes: PDPN; GP36; PSEC0003; PSEC0025
Study 22464259 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 22079192 — Predictive Biomarker (PRD): SLC39A2 mRNA
Genes: SLC39A2; ZIP2
Study 29779821 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 27210234 — Predictive Biomarker (PRD): FMOD mRNA
Genes: FMOD; FM; SLRR2E
Study 2268740 — Surrogate Endpoint (SUR): Bone mineral density
Study 2268740 — Surrogate Endpoint (SUR): Serum calcium
Study 23770157 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 22303710 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22303710 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 10708256 — Surrogate Endpoint (SUR): Bone mineral density
Study 1283590 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29364489 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 27005405 — Surrogate Endpoint (SUR): Blood pressure
Study 16485047 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3606739 — Surrogate Endpoint (SUR): Blood pressure
Study 17371478 — Surrogate Endpoint (SUR): Serum testosterone
Study 12928050 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 8378100 — Surrogate Endpoint (SUR): Blood pressure
Study 23575741 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 12912805 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11176015 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8318480 — Surrogate Endpoint (SUR): Blood pressure
Study 21420555 — Safety Biomarker (SAF): Hyaluronic acid
Study 15386949 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 15386949 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 15386949 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 9834040 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 9834040 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 8590556 — Surrogate Endpoint (SUR): Blood pressure
Study 31282081 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 18163016 — Predictive Biomarker (PRD): OAT mRNA
Genes: OAT
Study 23947316 — Surrogate Endpoint (SUR): Blood pressure
Study 8871425 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 7123952 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 29695706 — Surrogate Endpoint (SUR): Blood pressure
Study 29672747 — Predictive Biomarker (PRD): ASAH1 mRNA
Genes: ASAH1; ASAH; HSD-33; HSD33
Study 29694504 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29694504 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 29694504 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 27160957 — Surrogate Endpoint (SUR): Blood pressure
Study 24527505 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 20069077 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 20069077 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7906572 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7906572 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 3300903 — Surrogate Endpoint (SUR): Blood pressure
Study 21035594 — Surrogate Endpoint (SUR): Blood pressure
Study 10622067 — Surrogate Endpoint (SUR): Blood pressure
Study 25402757 — Predictive Biomarker (PRD): TCP1 mRNA
Genes: TCP1; CCT1; CCTA
Study 25402757 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25402757 — Surrogate Endpoint (SUR): Blood pressure
Study 25402757 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22866292 — Predictive Biomarker (PRD): LNX1 mRNA
Genes: LNX1; LNX; PDZRN2; UNQ574/PRO1136
Study 19349323 — Surrogate Endpoint (SUR): Blood pressure
Study 1582275 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28235524 — Surrogate Endpoint (SUR): Blood pressure
Study 15450785 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC6A4 mRNA
Genes: SLC6A4; HTT; SERT
Study 6814227 — Surrogate Endpoint (SUR): Blood pressure
Study 3878652 — Surrogate Endpoint (SUR): Blood pressure
Study 29091471 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27621189 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 24515273 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 22938661 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 9025126 — Surrogate Endpoint (SUR): Blood pressure
Study 1792912 — Predictive Biomarker (PRD): HRG mRNA
Genes: HRG
Study 1792912 — Predictive Biomarker (PRD): HHEX mRNA
Genes: HHEX; HEX; PRH; PRHX
Study 30358831 — Surrogate Endpoint (SUR): Blood pressure
Study 16277798 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 9505567 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 30790069 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 30790069 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Tumor mutational burden
Study 17485968 — Surrogate Endpoint (SUR): Blood pressure
Study 15900306 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12164888 — Surrogate Endpoint (SUR): Blood pressure
Study 24938711 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 21768610 — Surrogate Endpoint (SUR): Serum triglycerides
Study 11779098 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 11779098 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 7995329 — Surrogate Endpoint (SUR): Blood pressure
Study 25970665 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19916995 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 19916995 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 18376000 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18376000 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11053614 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 11053614 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15919453 — Surrogate Endpoint (SUR): Serum creatinine
Study 12949361 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12949361 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12949361 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26930568 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 26930568 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26930568 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26930568 — Safety Biomarker (SAF): Pentraxin-related protein PTX3
Genes: PTX3; TNFAIP5; TSG14
Study 25203332 — Surrogate Endpoint (SUR): Blood pressure
Study 22753773 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17662102 — Monitoring Biomarker (MOI): HBV DNA
Study 23485413 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 19154656 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 28911085 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 6360055 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 11916904 — Predictive Biomarker (PRD): GK mRNA
Genes: GK
Study 7586765 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1971504 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24618069 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 8559437 — Surrogate Endpoint (SUR): Bone mineral density
Study 2558701 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29977072 — Predictive Biomarker (PRD): ENTPD1 mRNA
Genes: ENTPD1; CD39
Study 29977072 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22849818 — Safety Biomarker (SAF): Interleukin 12
Study 25959199 — Surrogate Endpoint (SUR): Serum creatinine
Study 25959199 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 30179720 — Surrogate Endpoint (SUR): Bone mineral density
Study 12975389 — Surrogate Endpoint (SUR): Blood pressure
Study 6189412 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 28958152 — Surrogate Endpoint (SUR): Blood pressure
Study 27471039 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 20797478 — Surrogate Endpoint (SUR): Blood pressure
Study 20797478 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20797478 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16239176 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 9116274 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 24261700 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 14652636 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 14652636 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 14652636 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14652636 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27514411 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 27514411 — Surrogate Endpoint (SUR): Serum creatinine
Study 27514411 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 27514411 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 22040450 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 20159176 — Surrogate Endpoint (SUR): Bone mineral density
Study 20159176 — Surrogate Endpoint (SUR): Serum calcium
Study 18470901 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 3580251 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 22319038 — Predictive Biomarker (PRD): FGFR1 mRNA
Genes: FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR
Study 22319038 — Predictive Biomarker (PRD): FGF8 mRNA
Genes: FGF8; AIGF
Study 18487899 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16174275 — Surrogate Endpoint (SUR): Probing pocket depth
Study 8732710 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 1745353 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4