TrialPanorama/TrialPanorama-database huggingface dataset:
Study 25273342 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25273342 — Predictive Biomarker (PRD): Hormone receptor
Study 25273342 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 20131246 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 19730965 — Surrogate Endpoint (SUR): Blood pressure
Study 17404152 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 1460202 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 26916239 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 23899372 — Surrogate Endpoint (SUR): Blood pressure
Study 12745095 — Surrogate Endpoint (SUR): Serum creatinine
Study 10855739 — Surrogate Endpoint (SUR): Blood pressure
Study 3941533 — Surrogate Endpoint (SUR): Blood pressure
Study 30191972 — Surrogate Endpoint (SUR): Platelet count response
Study 26811524 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 24908236 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24908236 — Surrogate Endpoint (SUR): Blood pressure
Study 18312772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18312772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17000891 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 3082733 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 29135458 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 27153085 — Surrogate Endpoint (SUR): Blood pressure
Study 18593773 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18593773 — Surrogate Endpoint (SUR): Blood pressure
Study 7923801 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 27129013 — Pharmacodynamic Biomarker (PDY): Beta-secretase 1
Genes: BACE1; BACE; KIAA1149
Study 23374147 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23374147 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 23374147 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 23374147 — Predictive Biomarker (PRD): IL2
Genes: IL-2; TCGF
Study 23374147 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23374147 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 21307142 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 21307142 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 9855480 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 16920653 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 15232792 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 15540421 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15540421 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25601762 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 18057662 — Surrogate Endpoint (SUR): Bone mineral density
Study 28781026 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21216310 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16626544 — Surrogate Endpoint (SUR): Blood pressure
Study 15380463 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15380463 — Surrogate Endpoint (SUR): Bone mineral density
Study 19403636 — Surrogate Endpoint (SUR): Bone mineral density
Study 11298623 — Pharmacodynamic Biomarker (PDY): Tropomyosin-related kinase A
Genes: NTRK1; MTC; TRK; TRKA
Study 8200716 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 22336574 — Surrogate Endpoint (SUR): Blood pressure
Study 11914101 — Surrogate Endpoint (SUR): Blood pressure
Study 1414897 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 1414897 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31176289 — Surrogate Endpoint (SUR): Blood pressure
Study 10746528 — Surrogate Endpoint (SUR): Blood pressure
Study 23134959 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12898858 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12898858 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 8538480 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 8538480 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8538480 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21499896 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 21499896 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 17915799 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 15205383 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 3662059 — Surrogate Endpoint (SUR): Blood pressure
Study 29766318 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 27805026 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24974961 — Surrogate Endpoint (SUR): Blood pressure
Study 16192545 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8608877 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 29049415 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 29049415 — Predictive Biomarker (PRD): RAPGEF5 mRNA
Genes: RAPGEF5; GFR; KIAA0277; MRGEF
Study 29049415 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29049415 — Surrogate Endpoint (SUR): Blood pressure
Study 29049415 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27574399 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27574399 — Surrogate Endpoint (SUR): Blood pressure
Study 24644541 — Surrogate Endpoint (SUR): Blood pressure
Study 16707912 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 6873133 — Surrogate Endpoint (SUR): Blood pressure
Study 22892157 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 20462054 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20462054 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 18260838 — Surrogate Endpoint (SUR): Blood pressure
Study 17126656 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 17126656 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17126656 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 8328365 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8328365 — Surrogate Endpoint (SUR): Blood pressure
Study 29047142 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29047142 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 8517426 — Surrogate Endpoint (SUR): Blood pressure
Study 19378542 — Surrogate Endpoint (SUR): Blood pressure
Study 11036134 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21443793 — Surrogate Endpoint (SUR): Serum calcium
Study 1911606 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 1911606 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 19292807 — Predictive Biomarker (PRD): Hormone receptor
Study 17727573 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 15118640 — Surrogate Endpoint (SUR): Blood pressure
Study 26176805 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 22012522 — Surrogate Endpoint (SUR): Bone mineral density
Study 12859312 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12859312 — Surrogate Endpoint (SUR): Blood pressure
Study 1755537 — Surrogate Endpoint (SUR): Blood pressure
Study 23871569 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 15291234 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 9475308 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 9475308 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27761966 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 24160231 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21923449 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 21923449 — Surrogate Endpoint (SUR): Blood pressure
Study 16597655 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 12971812 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 28976426 — Surrogate Endpoint (SUR): Serum creatinine
Study 24043751 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 24043751 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 17273582 — Surrogate Endpoint (SUR): Forced vital capacity
Study 28829877 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27927601 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7685226 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7685226 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 6118980 — Surrogate Endpoint (SUR): Blood pressure
Study 31211381 — Predictive Biomarker (PRD): FABP4 mRNA
Genes: FABP4
Study 20012609 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20012609 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 20012609 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 20012609 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31272408 — Pharmacodynamic Biomarker (PDY): Ataxin-3
Genes: ATXN3; ATX3; MJD; MJD1; SCA3
Study 24131304 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 24131304 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 26329841 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18447211 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16392100 — Surrogate Endpoint (SUR): Serum calcium
Study 11192138 — Surrogate Endpoint (SUR): Blood pressure
Study 9159299 — Surrogate Endpoint (SUR): Blood pressure
Study 26597415 — Surrogate Endpoint (SUR): Blood pressure
Study 13678869 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26670987 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26670987 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 22205314 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 15728784 — Surrogate Endpoint (SUR): Serum creatinine
Study 22571813 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 9780763 — Surrogate Endpoint (SUR): Blood pressure
Study 7932518 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26756383 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25316130 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 18259028 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18259028 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 28404092 — Monitoring Biomarker (MOI): HBV DNA
Study 28404092 — Surrogate Endpoint (SUR): Bone mineral density
Study 28404092 — Surrogate Endpoint (SUR): Serum creatinine
Study 22281609 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 22281609 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 22281609 — Predictive Biomarker (PRD): HSPA8 mRNA
Genes: HSPA8; HSC70; HSP73; HSPA10
Study 22281609 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 22281609 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30371854 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 30371854 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 8782139 — Predictive Biomarker (PRD): KLHL17 mRNA
Genes: KLHL17; AF
Study 6144620 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 30148432 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28482641 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 28482641 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 23098160 — Surrogate Endpoint (SUR): Blood pressure
Study 23098160 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11040229 — Safety Biomarker (SAF): Transforming growth factor beta 1
Genes: TGFB1; TGFB
Study 1534581 — Surrogate Endpoint (SUR): Blood pressure
Study 16156884 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11914565 — Surrogate Endpoint (SUR): Blood pressure
Study 26549488 — Predictive Biomarker (PRD): KCNK3 mRNA
Genes: KCNK3; TASK; TASK1
Study 20084307 — Surrogate Endpoint (SUR): Blood pressure
Study 9338731 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 20106825 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 9347199 — Surrogate Endpoint (SUR): Blood pressure
Study 8227867 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 12502976 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 12502976 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 12502976 — Surrogate Endpoint (SUR): Blood pressure
Study 8842505 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23128937 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 15023611 — Surrogate Endpoint (SUR): Blood pressure
Study 23383459 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 23383459 — Surrogate Endpoint (SUR): Blood pressure
Study 2861880 — Surrogate Endpoint (SUR): Blood pressure
Study 29306452 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 27566742 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 20497992 — Surrogate Endpoint (SUR): Blood pressure
Study 9088894 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 17291336 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 10482198 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 7568633 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 6795164 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31651944 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 31651944 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 31651944 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26246458 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 22935227 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 19899831 — Predictive Biomarker (PRD): MARS1 mRNA
Genes: MARS1; MARS
Study 15220251 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15220251 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 12665701 — Surrogate Endpoint (SUR): Bone mineral density
Study 30395350 — Surrogate Endpoint (SUR): Blood pressure
Study 16845252 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8883115 — Surrogate Endpoint (SUR): Bone mineral density
Study 26465137 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 25186834 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 25186834 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 25186834 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 25186834 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25186834 — Safety Biomarker (SAF): Reactive oxygen species
Study 20660279 — Surrogate Endpoint (SUR): Blood pressure
Study 15947736 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28677349 — Predictive Biomarker (PRD): HBB mRNA
Genes: HBB
Study 17287478 — Safety Biomarker (SAF): Interleukin 12
Study 9228873 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 3301120 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 20110274 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17826496 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 15156950 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 9692448 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 2193493 — Surrogate Endpoint (SUR): Blood pressure
Study 2193493 — Surrogate Endpoint (SUR): Serum triglycerides
Study 2193493 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2193493 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10750670 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10750670 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21388444 — Surrogate Endpoint (SUR): Blood pressure
Study 16969592 — Predictive Biomarker (PRD): ASRGL1 mRNA
Genes: ASRGL1; ALP; CRASH
Study 16969592 — Surrogate Endpoint (SUR): Bone mineral density
Study 30118904 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 25682724 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 16565237 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16565237 — Surrogate Endpoint (SUR): Serum creatinine
Study 14578725 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9017582 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 6381871 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31113795 — Predictive Biomarker (PRD): CXCR2 mRNA
Genes: CXCR2; IL8RB
Study 25382402 — Surrogate Endpoint (SUR): Bone mineral density
Study 25382402 — Surrogate Endpoint (SUR): Serum calcium
Study 25382402 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 20827170 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12042621 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 12042621 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 10450005 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 10450005 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 31785550 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 20520601 — Predictive Biomarker (PRD): ADORA2A mRNA
Genes: ADORA2A; ADORA2
Study 20520601 — Predictive Biomarker (PRD): ADORA1 mRNA
Genes: ADORA1
Study 12704369 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 22410350 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 20463178 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 20463178 — Surrogate Endpoint (SUR): Serum potassium
Study 18360012 — Surrogate Endpoint (SUR): Blood pressure
Study 18360012 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18360012 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10078667 — Surrogate Endpoint (SUR): Blood pressure
Study 28465557 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 23184900 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 23184900 — Surrogate Endpoint (SUR): Blood pressure
Study 23184900 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19914548 — Predictive Biomarker (PRD): Hormone receptor
Study 8033506 — Surrogate Endpoint (SUR): Blood pressure
Study 23360676 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14651539 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 10468028 — Safety Biomarker (SAF): 51Cr-EDTA
Study 582982 — Surrogate Endpoint (SUR): Blood pressure
Study 582982 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 15524059 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15524059 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9625834 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 29873468 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16624769 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 15010338 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15010338 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 18721518 — Surrogate Endpoint (SUR): Blood pressure
Study 10326791 — Surrogate Endpoint (SUR): Bone mineral density
Study 9432097 — Surrogate Endpoint (SUR): Serum potassium
Study 21225239 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16945231 — Surrogate Endpoint (SUR): Blood pressure
Study 12656544 — Surrogate Endpoint (SUR): Serum creatinine