TrialPanorama/TrialPanorama-database huggingface dataset:
Study 26305067 — Predictive Biomarker (PRD): PNPLA3 mRNA
Genes: PNPLA3; ADPN; C22orf20
Study 10806942 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 7491367 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 16923090 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 23529800 — Surrogate Endpoint (SUR): Bone mineral density
Study 21253777 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 16165158 — Surrogate Endpoint (SUR): Blood pressure
Study 15529377 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23759000 — Surrogate Endpoint (SUR): Blood pressure
Study 7856286 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30211826 — Surrogate Endpoint (SUR): Blood pressure
Study 25803604 — Surrogate Endpoint (SUR): Blood pressure
Study 3347325 — Surrogate Endpoint (SUR): Blood pressure
Study 31133624 — Surrogate Endpoint (SUR): Blood pressure
Study 25812483 — Predictive Biomarker (PRD): ACAD8 mRNA
Genes: ACAD8; ARC42; IBD
Study 18957313 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 18957313 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 15564693 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 7750174 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 2532741 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 30945431 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 29574980 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20434097 — Surrogate Endpoint (SUR): Blood pressure
Study 2318518 — Surrogate Endpoint (SUR): Blood pressure
Study 28285845 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 28285845 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 3306374 — Surrogate Endpoint (SUR): Serum creatinine
Study 25762357 — Predictive Biomarker (PRD): ACAD8 mRNA
Genes: ACAD8; ARC42; IBD
Study 19090875 — Surrogate Endpoint (SUR): Blood pressure
Study 3085552 — Surrogate Endpoint (SUR): Blood pressure
Study 27154159 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15963399 — Surrogate Endpoint (SUR): Serum creatinine
Study 15963399 — Surrogate Endpoint (SUR): Blood pressure
Study 12835083 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 12835083 — Surrogate Endpoint (SUR): Serum creatinine
Study 22764598 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 3344301 — Surrogate Endpoint (SUR): Blood pressure
Study 2131504 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21088959 — Predictive Biomarker (PRD): DRD4 mRNA
Genes: DRD4
Study 21088959 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 11394513 — Surrogate Endpoint (SUR): Blood pressure
Study 29488475 — Surrogate Endpoint (SUR): Blood pressure
Study 25361980 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 25361980 — Predictive Biomarker (PRD): PIK3CA mRNA
Genes: PIK3CA
Study 25361980 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 16393442 — Surrogate Endpoint (SUR): Blood pressure
Study 10404349 — Surrogate Endpoint (SUR): Blood pressure
Study 2176518 — Surrogate Endpoint (SUR): Blood pressure
Study 3886301 — Surrogate Endpoint (SUR): Blood pressure
Study 26382733 — Predictive Biomarker (PRD): CD22 mRNA
Genes: CD22; SIGLEC2
Study 26382733 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 26382733 — Predictive Biomarker (PRD): CD27 mRNA
Genes: CD27; TNFRSF7
Study 26382733 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 11120935 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19638646 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 15142218 — Surrogate Endpoint (SUR): Probing pocket depth
Study 21332412 — Surrogate Endpoint (SUR): Blood pressure
Study 15198763 — Surrogate Endpoint (SUR): Blood pressure
Study 31509849 — Predictive Biomarker (PRD): COL1A1 mRNA
Genes: COL1A1
Study 31509849 — Predictive Biomarker (PRD): COL1A2 mRNA
Genes: COL1A2
Study 31509849 — Predictive Biomarker (PRD): COL3A1 mRNA
Genes: COL3A1
Study 30912296 — Surrogate Endpoint (SUR): Blood pressure
Study 10735496 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 8723395 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18049943 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 16255136 — Predictive Biomarker (PRD): GCNT2 mRNA
Genes: GCNT2; GCNT5; II; NACGT1
Study 8852543 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23406477 — Predictive Biomarker (PRD): AMT mRNA
Genes: AMT; GCST
Study 9703380 — Surrogate Endpoint (SUR): Serum testosterone
Study 788759 — Surrogate Endpoint (SUR): Blood pressure
Study 23537231 — Predictive Biomarker (PRD): C1QL1 mRNA
Genes: C1QL1; C1QRF; CRF; CTRP14
Study 21739910 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 12771924 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 27565018 — Predictive Biomarker (PRD): KLHL17 mRNA
Genes: KLHL17; AF
Study 25000528 — Predictive Biomarker (PRD): TBC1D4 mRNA
Genes: TBC1D4; AS160; KIAA0603
Study 22878697 — Predictive Biomarker (PRD): NPC1L1 mRNA
Genes: NPC1L1
Study 22878697 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 19910834 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10809860 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10809860 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10809860 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 19799615 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 17566099 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 6152880 — Surrogate Endpoint (SUR): Blood pressure
Study 31319633 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 27476722 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HLA-C
Genes: HLA-JY3, D6S204, PSORS1
Study 12460700 — Surrogate Endpoint (SUR): Blood pressure
Study 10342710 — Surrogate Endpoint (SUR): Bone mineral density
Study 7500633 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7500633 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 31205435 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21939561 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11775134 — Surrogate Endpoint (SUR): Blood pressure
Study 8276044 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 27029592 — Surrogate Endpoint (SUR): Blood pressure
Study 24711047 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 29306453 — Surrogate Endpoint (SUR): Blood pressure
Study 24284025 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20082715 — Safety Biomarker (SAF): Reactive oxygen species
Study 12207630 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 10792845 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 10792845 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6097665 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18544158 — Surrogate Endpoint (SUR): Blood pressure
Study 16115357 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 16115357 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 12423712 — Surrogate Endpoint (SUR): Blood pressure
Study 7591024 — Surrogate Endpoint (SUR): Blood pressure
Study 23828145 — Surrogate Endpoint (SUR): Bone mineral density
Study 15208869 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 26498324 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 24683472 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 24683472 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 24683472 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 24683472 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22078632 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19293263 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 17712402 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17712402 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 9272811 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 9272811 — Predictive Biomarker (PRD): SLC35A2 mRNA
Genes: SLC35A2; UGALT; UGT; UGTL
Study 24655714 — Predictive Biomarker (PRD): SREBF1 mRNA
Genes: SREBF1; BHLHD1; SREBP1
Study 24655714 — Predictive Biomarker (PRD): INSIG1 mRNA
Genes: INSIG1
Study 24655714 — Predictive Biomarker (PRD): SH2D2A mRNA
Genes: SH2D2A; SCAP; TSAD; VRAP
Study 20185416 — Predictive Biomarker (PRD): ARL2BP mRNA
Genes: ARL2BP; BART; BART1
Study 12173196 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12173196 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 12173196 — Safety Biomarker (SAF): IL-6 and IL-10
Study 12173196 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9443711 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 2379255 — Predictive Biomarker (PRD): DPT mRNA
Genes: DPT
Study 26424639 — Predictive Biomarker (PRD): FHL5 mRNA
Genes: FHL5; ACT
Study 21835296 — Surrogate Endpoint (SUR): Blood pressure
Study 21835296 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19843489 — Surrogate Endpoint (SUR): Blood pressure
Study 2840050 — Surrogate Endpoint (SUR): Blood pressure
Study 19482378 — Surrogate Endpoint (SUR): Blood pressure
Study 12694345 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10024108 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10024108 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25131348 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 9869506 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2919600 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 19363107 — Surrogate Endpoint (SUR): Blood pressure
Study 9305483 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 2572741 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 979915 — Predictive Biomarker (PRD): POMP mRNA
Genes: POMP; C13orf12; UMP1; HSPC014; HSPC036; PNAS-110
Study 29282108 — Surrogate Endpoint (SUR): Blood pressure
Study 22104255 — Surrogate Endpoint (SUR): Forced vital capacity
Study 20216107 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 15679714 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 11196124 — Surrogate Endpoint (SUR): Blood pressure
Study 10294790 — Surrogate Endpoint (SUR): Blood pressure
Study 28282558 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28282558 — Safety Biomarker (SAF): Interleukin 1
Study 15229817 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 15647341 — Surrogate Endpoint (SUR): Blood pressure
Study 15647341 — Surrogate Endpoint (SUR): Serum calcium
Study 12532112 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6828559 — Surrogate Endpoint (SUR): Blood pressure
Study 29791970 — Predictive Biomarker (PRD): HRC mRNA
Genes: HRC; HCP
Study 17973730 — Surrogate Endpoint (SUR): Blood pressure
Study 20203627 — Surrogate Endpoint (SUR): Blood pressure
Study 1828659 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1828659 — Surrogate Endpoint (SUR): Blood pressure
Study 19684155 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Osteopontin
Genes: SPP1; BNSP; OPN; PSEC0156
Study 10560790 — Surrogate Endpoint (SUR): Blood pressure
Study 8712394 — Surrogate Endpoint (SUR): Blood pressure
Study 29952801 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 23686738 — Surrogate Endpoint (SUR): Bone mineral density
Study 30707660 — Predictive Biomarker (PRD): BTC mRNA
Genes: BTC
Study 27265507 — Surrogate Endpoint (SUR): Blood pressure
Study 23031143 — Surrogate Endpoint (SUR): Blood pressure
Study 20576804 — Surrogate Endpoint (SUR): Blood pressure
Study 17953922 — Surrogate Endpoint (SUR): Serum creatinine
Study 9857596 — Surrogate Endpoint (SUR): Probing pocket depth
Study 12949359 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 29727403 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27511325 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27511325 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20139767 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 18695911 — Pharmacodynamic Biomarker (PDY): Signal transducer and activator of transcription 3
Genes: STAT3; APRF
Study 30407633 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 30407633 — Predictive Biomarker (PRD): FADS1 mRNA
Genes: FADS1; FADSD5
Study 30407633 — Predictive Biomarker (PRD): FADS2 mRNA
Genes: FADS2
Study 30407633 — Predictive Biomarker (PRD): ELOVL2 mRNA
Genes: ELOVL2; ELG3; SSC2
Study 30407633 — Predictive Biomarker (PRD): ELOVL5 mRNA
Genes: ELOVL5; ELOVL2; PRO0530
Study 30407633 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 30407633 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 30407633 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 30407633 — Predictive Biomarker (PRD): LIPF mRNA
Genes: LIPF
Study 22025997 — Surrogate Endpoint (SUR): Probing pocket depth
Study 16469442 — Predictive Biomarker (PRD): MCAT mRNA
Genes: MCAT; MT
Study 16469442 — Predictive Biomarker (PRD): CIT mRNA
Genes: CIT; CRIK; KIAA0949; STK21
Study 10846595 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24315475 — Predictive Biomarker (PRD): CNR1 mRNA
Genes: CNR1; CNR
Study 16359283 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 2096108 — Surrogate Endpoint (SUR): Blood pressure
Study 24174392 — Surrogate Endpoint (SUR): Blood pressure
Study 25280132 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 25280132 — Surrogate Endpoint (SUR): Bone mineral density
Study 22646698 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12626202 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 31911516 — Surrogate Endpoint (SUR): Blood pressure
Study 31911516 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23357491 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19470803 — Predictive Biomarker (PRD): BABAM2 mRNA
Genes: BABAM2; BRCC45; BRE
Study 28277603 — Surrogate Endpoint (SUR): Bone mineral density
Study 21493792 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21493792 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16442916 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 15274684 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6662184 — Surrogate Endpoint (SUR): Blood pressure
Study 6662184 — Surrogate Endpoint (SUR): Serum uric acid
Study 6662184 — Surrogate Endpoint (SUR): Serum potassium
Study 31504541 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31504541 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27085587 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 27085587 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 19141778 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 17607003 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 25442169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25442169 — Safety Biomarker (SAF): Interleukin 1
Study 25442169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25442169 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 25442169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16454979 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16454979 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1533427 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 24456286 — Surrogate Endpoint (SUR): Bone mineral density
Study 20837928 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18432253 — Surrogate Endpoint (SUR): Blood pressure
Study 2276107 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 28477678 — Surrogate Endpoint (SUR): Blood pressure
Study 26471180 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26471180 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17242413 — Surrogate Endpoint (SUR): Blood pressure
Study 2574081 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 24580388 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2427808 — Surrogate Endpoint (SUR): Blood pressure
Study 18295613 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 31079203 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 28924368 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 29789518 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 29789518 — Surrogate Endpoint (SUR): Serum triglycerides
Study 20651059 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 20651059 — Predictive Biomarker (PRD): Carbonic anhydrase IX
Genes: CA9; G250; MN
Study 20651059 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 20651059 — Predictive Biomarker (PRD): VHL mRNA
Genes: VHL
Study 20651059 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 31492775 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31492775 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27900987 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27900987 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25248815 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11806983 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 30760125 — Surrogate Endpoint (SUR): Blood pressure
Study 30171280 — Predictive Biomarker (PRD); Safety Biomarker (SAF): ABCG2
Genes: EST157481; MXR; BCRP; ABCP; CD338
Study 23602247 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23602247 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23602247 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23602247 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20689455 — Predictive Biomarker (PRD): MIF mRNA
Genes: MIF; GLIF; MMIF
Study 20689455 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 7962426 — Predictive Biomarker (PRD): TNFRSF25 mRNA
Genes: TNFRSF25; APO3; DDR3; DR3; TNFRSF12; WSL; WSL1; UNQ455/PRO779
Study 16714461 — Surrogate Endpoint (SUR): Serum creatinine
Study 25237196 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16278616 — Surrogate Endpoint (SUR): Blood pressure
Study 9860147 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7884114 — Surrogate Endpoint (SUR): Serum calcium
Study 31040122 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 19891014 — Predictive Biomarker (PRD): MTR mRNA
Genes: MTR
Study 11503008 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 8487006 — Surrogate Endpoint (SUR): Blood pressure
Study 29895330 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 29895330 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 20717951 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 16354850 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16354850 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 19366494 — Predictive Biomarker (PRD): CDS1 mRNA
Genes: CDS1; CDS
Study 9279201 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 30359300 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 22921698 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10806125 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 10806125 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 20644019 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 12044272 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 31699704 — Predictive Biomarker (PRD): TNFRSF1B mRNA
Genes: TNFRSF1B; TNFBR; TNFR2