TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23697261 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 20571774 — Surrogate Endpoint (SUR): Bone mineral density
Study 15042429 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 9029223 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 7705854 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 3129938 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25636328 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 18360017 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 18360017 — Surrogate Endpoint (SUR): Blood pressure
Study 18360017 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18360017 — Surrogate Endpoint (SUR): Serum potassium
Study 30585459 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 18952164 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16952814 — Surrogate Endpoint (SUR): Blood pressure
Study 8373602 — Surrogate Endpoint (SUR): Blood pressure
Study 14662904 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11266148 — Surrogate Endpoint (SUR): Blood pressure
Study 11266148 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2500169 — Surrogate Endpoint (SUR): Blood pressure
Study 2500169 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2500169 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31884074 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 31884074 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 31884074 — Predictive Biomarker (PRD): IGF2 mRNA
Genes: IGF2; PP1446
Study 29652761 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 20211020 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22331521 — Predictive Biomarker (PRD): MTOR mRNA
Genes: MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Study 16900082 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 7020900 — Surrogate Endpoint (SUR): Blood pressure
Study 31549793 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27168475 — Surrogate Endpoint (SUR): Blood pressure
Study 25060413 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17207172 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 23886272 — Predictive Biomarker (PRD): NLRP3 mRNA
Genes: NLRP3; C1orf7; CIAS1; NALP3; PYPAF1
Study 15764270 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 7304657 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28780479 — Predictive Biomarker (PRD): TWIST1 mRNA
Genes: TWIST1; BHLHA38; TWIST
Study 17223870 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 27868372 — Surrogate Endpoint (SUR): Blood pressure
Study 26065919 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 26163088 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 12649125 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1418078 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 30883859 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17472485 — Predictive Biomarker (PRD): GLS2 mRNA
Genes: GLS2; GA
Study 25933111 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 16009445 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 16009445 — Surrogate Endpoint (SUR): Serum uric acid
Study 10849577 — Surrogate Endpoint (SUR): Blood pressure
Study 30782675 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 18046991 — Predictive Biomarker (PRD): KMO mRNA
Genes: KMO
Study 15818711 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 9890616 — Surrogate Endpoint (SUR): Bone mineral density
Study 9049962 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 26475845 — Surrogate Endpoint (SUR): Blood pressure
Study 21947409 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19211720 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 19211720 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 17308271 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 11093967 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 11093967 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 11093967 — Surrogate Endpoint (SUR): Serum triglycerides
Study 28573777 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 28573777 — Surrogate Endpoint (SUR): Blood pressure
Study 25669832 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 1650750 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 1650750 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 24530403 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18603822 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 12377843 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10357386 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7584529 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 24610631 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 21448165 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 2847522 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2847522 — Surrogate Endpoint (SUR): Blood pressure
Study 18300365 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31347692 — Safety Biomarker (SAF): Succinate dehydrogenase
Genes: SDHD
Study 30096700 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 22170367 — Predictive Biomarker (PRD): ADORA2A mRNA
Genes: ADORA2A; ADORA2
Study 22170367 — Predictive Biomarker (PRD): ADRA2B mRNA
Genes: ADRA2B; ADRA2L1; ADRA2RL1
Study 17696221 — Predictive Biomarker (PRD): HGS mRNA
Genes: HGS; HRS
Study 10540564 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 8535647 — Predictive Biomarker (PRD): ASPRV1 mRNA
Genes: ASPRV1; SASP
Study 17925339 — Predictive Biomarker (PRD): LTB mRNA
Genes: LTB; TNFC; TNFSF3
Study 17925339 — Surrogate Endpoint (SUR): Blood pressure
Study 6996120 — Surrogate Endpoint (SUR): Blood pressure
Study 23052798 — Surrogate Endpoint (SUR): Serum calcium
Study 19474735 — Predictive Biomarker (PRD): CAMP mRNA
Genes: CAMP; CAP18; FALL39; HSD26
Study 10979113 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10979113 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8799880 — Surrogate Endpoint (SUR): Blood pressure
Study 18477407 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 18477407 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18477407 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 16796458 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 16796458 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 12641503 — Surrogate Endpoint (SUR): Bone mineral density
Study 30780196 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 30780196 — Safety Biomarker (SAF): BDNF
Study 19733016 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 19733016 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 17965037 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 22845695 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 22845695 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22845695 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 20627818 — Surrogate Endpoint (SUR): Blood pressure
Study 12574564 — Surrogate Endpoint (SUR): Blood pressure
Study 24965385 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 18455192 — Surrogate Endpoint (SUR): Blood pressure
Study 15796146 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 10390227 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6647195 — Surrogate Endpoint (SUR): Blood pressure
Study 26713403 — Surrogate Endpoint (SUR): Bone mineral density
Study 10493845 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10493845 — Surrogate Endpoint (SUR): Blood pressure
Study 6848810 — Surrogate Endpoint (SUR): Serum potassium
Study 30885666 — Predictive Biomarker (PRD): Hypoxia-inducible factor 1-alpha
Genes: HIF1A; BHLHE78; MOP1; PASD8
Study 25918718 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 23710686 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 22048172 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17405996 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30795951 — Predictive Biomarker (PRD): Hormone receptor
Study 30795951 — Surrogate Endpoint (SUR): Bone mineral density
Study 29769107 — Surrogate Endpoint (SUR): Blood pressure
Study 26996580 — Surrogate Endpoint (SUR): Forced vital capacity
Study 25219783 — Safety Biomarker (SAF): Reactive oxygen species
Study 21143094 — Surrogate Endpoint (SUR): Serum creatinine
Study 9541761 — Predictive Biomarker (PRD): CALD1 mRNA
Genes: CALD1; CAD; CDM
Study 31834381 — Predictive Biomarker (PRD): CHRNA5 mRNA
Genes: CHRNA5; NACHRA5
Study 28610969 — Predictive Biomarker (PRD): CHIC2 mRNA
Genes: CHIC2; BTL
Study 12850465 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12850465 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12850465 — Safety Biomarker (SAF): IL-6 and IL-10
Study 21332626 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 8086986 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 18803492 — Surrogate Endpoint (SUR): Blood pressure
Study 10922313 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 28619235 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 17493777 — Surrogate Endpoint (SUR): Bone mineral density
Study 23152480 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16823725 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 16823725 — Surrogate Endpoint (SUR): Bone mineral density
Study 14638924 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 10904025 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10904025 — Surrogate Endpoint (SUR): Blood pressure
Study 3030387 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3030387 — Surrogate Endpoint (SUR): Blood pressure
Study 31731111 — Surrogate Endpoint (SUR): Serum sodium
Study 25164452 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 20616365 — Predictive Biomarker (PRD): CNBP mRNA
Genes: CNBP; RNF163; ZNF9
Study 15516352 — Surrogate Endpoint (SUR): Blood pressure
Study 10596996 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 7023861 — Surrogate Endpoint (SUR): Forced vital capacity
Study 15336297 — Predictive Biomarker (PRD): CIT mRNA
Genes: CIT; CRIK; KIAA0949; STK21
Study 10601133 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 10601133 — Surrogate Endpoint (SUR): Blood pressure
Study 26849684 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22081557 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22081557 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22081557 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 20846424 — Predictive Biomarker (PRD): ARNT mRNA
Genes: ARNT; BHLHE2
Study 9500565 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 30806017 — Surrogate Endpoint (SUR): Forced vital capacity
Study 31999376 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 28182503 — Pharmacodynamic Biomarker (PDY): Lysosomal acid glucosylceramidase
Genes: GBA1; GBA; GC; GLUC
Study 21085591 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27185843 — Predictive Biomarker (PRD): FASN mRNA
Genes: FASN; FAS
Study 27185843 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 20178877 — Surrogate Endpoint (SUR): Blood pressure
Study 6408016 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 25396263 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17545705 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 25217464 — Predictive Biomarker (PRD): DMA mRNA
Genes: DMA; HLA-DMA; hCG_2001572
Study 25217464 — Surrogate Endpoint (SUR): Blood pressure
Study 20018274 — Pharmacodynamic Biomarker (PDY): Salivary secretion
Study 12226034 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10326889 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 7095559 — Monitoring Biomarker (MOI): HBV DNA
Study 26255546 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17321928 — Surrogate Endpoint (SUR): Blood pressure
Study 28539539 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16507585 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 16507585 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15640628 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15640628 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8996289 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 3545130 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 20540447 — Predictive Biomarker (PRD): PITRM1 mRNA
Genes: PITRM1; KIAA1104; MP1; PREP
Study 9974425 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 7572684 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19776178 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15343013 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 11181984 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11181984 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 11181984 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 11181984 — Surrogate Endpoint (SUR): Serum creatinine
Study 11181984 — Surrogate Endpoint (SUR): Blood pressure
Study 31982328 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 31336766 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 31336766 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 26655885 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 26655885 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 21435220 — Pharmacodynamic Biomarker (PDY): Survival motor neuron protein
Genes: SMN1; SMN; SMNT;; SMN2; SMNC
Study 21435220 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 18533896 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31512140 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31512140 — Surrogate Endpoint (SUR): Serum creatinine
Study 17192355 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 29079603 — Surrogate Endpoint (SUR): Blood pressure
Study 26138419 — Predictive Biomarker (PRD): miR-21-5p
Genes: MIR21
Study 26138419 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-21
Genes: MIR21
Study 11226106 — Surrogate Endpoint (SUR): Blood pressure
Study 27581505 — Surrogate Endpoint (SUR): Blood pressure
Study 22964475 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 18073061 — Monitoring Biomarker (MOI): HBV DNA
Study 10603440 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 8682011 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 19723905 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 12477321 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9401833 — Surrogate Endpoint (SUR): Blood pressure
Study 16632411 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16632411 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10811665 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 10811665 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 30766716 — Surrogate Endpoint (SUR): Bone mineral density
Study 20215520 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 20215520 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20215520 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20215520 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 10372727 — Surrogate Endpoint (SUR): Serum testosterone
Study 25885521 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23539083 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10090295 — Surrogate Endpoint (SUR): Blood pressure
Study 30643228 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 27592635 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 24699237 — Surrogate Endpoint (SUR): Bone mineral density
Study 15352909 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10204127 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 7774110 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 7437777 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 7437777 — Surrogate Endpoint (SUR): Blood pressure
Study 7437777 — Surrogate Endpoint (SUR): Serum creatinine
Study 21150933 — Surrogate Endpoint (SUR): Blood pressure
Study 17936154 — Surrogate Endpoint (SUR): Serum creatinine
Study 15378139 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7808646 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22749178 — Surrogate Endpoint (SUR): Blood pressure
Study 22749178 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22749178 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22749178 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22749178 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29563108 — Predictive Biomarker (PRD): TNFSF13B mRNA
Genes: TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; UNQ401/PRO738
Study 29563108 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 14684561 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 12663595 — Surrogate Endpoint (SUR): Blood pressure
Study 25210019 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23471702 — Surrogate Endpoint (SUR): Blood pressure
Study 20090396 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 11354573 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 9112303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9176830 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9176830 — Surrogate Endpoint (SUR): Serum triglycerides
Study 9176830 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1412606 — Surrogate Endpoint (SUR): Blood pressure
Study 30861510 — Safety Biomarker (SAF): Hyaluronic acid
Study 26972955 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26972955 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22490761 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 22490761 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22490761 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22490761 — Surrogate Endpoint (SUR): Blood pressure
Study 20942575 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20942575 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26164807 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24173773 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 18174269 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 18174269 — Surrogate Endpoint (SUR): Serum creatinine
Study 17023703 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14681839 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 12077738 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 9449404 — Surrogate Endpoint (SUR): Blood pressure
Study 2374275 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2374275 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20001867 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31126258 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL