TrialPanorama/TrialPanorama-database huggingface dataset:
Study 12577162 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 29806090 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11701427 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27054571 — Predictive Biomarker (PRD): CHRNA4 mRNA
Genes: CHRNA4; NACRA4
Study 23772804 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30677485 — Surrogate Endpoint (SUR): Blood pressure
Study 21059444 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21059444 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21059444 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 30940890 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30940890 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28646841 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 19682403 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19682403 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 15090796 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15090796 — Surrogate Endpoint (SUR): Undetectable plasma HIV RNA
Study 11319683 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28501140 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 12960187 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 10834774 — Surrogate Endpoint (SUR): Blood pressure
Study 12598068 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10547208 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 1808488 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 6619270 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 29167041 — Predictive Biomarker (PRD): CXADR mRNA
Genes: CXADR; CAR
Study 19786664 — Predictive Biomarker (PRD): Apoptosis regulator Bcl-2
Genes: BCL2
Study 19786664 — Predictive Biomarker (PRD): BCL6 mRNA
Genes: BCL6; BCL5; LAZ3; ZBTB27; ZNF51
Study 19786664 — Predictive Biomarker (PRD): IRF4 mRNA
Genes: IRF4; MUM1
Study 19786664 — Predictive Biomarker (PRD): LMO2 mRNA
Genes: LMO2; RBTN2; RBTNL1; RHOM2; TTG2
Study 19786664 — Predictive Biomarker (PRD): FOXP1 mRNA
Genes: FOXP1; HSPC215
Study 15118188 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 15118188 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 15118188 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 9715735 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 28944752 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 21741829 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 12580206 — Surrogate Endpoint (SUR): Blood pressure
Study 28581356 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 20694469 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 15612152 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 15612152 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 9515799 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 31688620 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 17223865 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17223865 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 17223865 — Predictive Biomarker (PRD): KLRD1 mRNA
Genes: KLRD1; CD94
Study 10357731 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 22108275 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18516718 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 1457360 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 17065180 — Surrogate Endpoint (SUR): Serum creatinine
Study 11313831 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 7949227 — Safety Biomarker (SAF): HLA-DQA1
Genes: CELIAC1
Study 7949227 — Safety Biomarker (SAF): HLA-DQB1
Genes: IDDM1; CELIAC1
Study 16755150 — Surrogate Endpoint (SUR): Blood pressure
Study 31764011 — Surrogate Endpoint (SUR): Blood pressure
Study 27170466 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27170466 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22045100 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 22045100 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 16364834 — Surrogate Endpoint (SUR): Blood pressure
Study 9872876 — Surrogate Endpoint (SUR): Blood pressure
Study 7404129 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 6363382 — Surrogate Endpoint (SUR): Serum creatinine
Study 6363382 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 29680656 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 24115129 — Surrogate Endpoint (SUR): Bone mineral density
Study 23122801 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 20352167 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 16078599 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16078599 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16078599 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 12410741 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1827568 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1827568 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30177585 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 30177585 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 23287846 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 23287846 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9412807 — Surrogate Endpoint (SUR): Blood pressure
Study 30304457 — Predictive Biomarker (PRD): MVP mRNA
Genes: MVP; LRP
Study 28265691 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 28265691 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 12827312 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 24013857 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 10335412 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20683173 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20683173 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20683173 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7986714 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7986714 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 26687696 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21636808 — Predictive Biomarker (PRD): CYBB mRNA
Genes: CYBB; NOX2
Study 21636808 — Safety Biomarker (SAF): Reactive oxygen species
Study 25614126 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 25614126 — Safety Biomarker (SAF): Interleukin 1
Study 29936918 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19390459 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 19390459 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11789242 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 11789242 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 9375537 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9375537 — Surrogate Endpoint (SUR): Blood pressure
Study 29025406 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 29025406 — Predictive Biomarker (PRD): GLS mRNA
Genes: GLS; GLS1; KIAA0838
Study 26736984 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 16700824 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 9067045 — Surrogate Endpoint (SUR): Blood pressure
Study 22762290 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 20558909 — Surrogate Endpoint (SUR): Blood pressure
Study 9192129 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1555902 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25237186 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 25237186 — Safety Biomarker (SAF): Reactive oxygen species
Study 19625274 — Predictive Biomarker (PRD): MMRN1 mRNA
Genes: MMRN1; ECM; EMILIN4; GPIA*; MMRN
Study 18846777 — Surrogate Endpoint (SUR): Blood pressure
Study 21938381 — Surrogate Endpoint (SUR): Bone mineral density
Study 31805854 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 31805854 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 31805854 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 31805854 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 24174625 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 17950161 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 11436683 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 9895420 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31541942 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 22367645 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 29689116 — Surrogate Endpoint (SUR): Serum creatinine
Study 25856220 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 25856220 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 26215206 — Surrogate Endpoint (SUR): Blood pressure
Study 18266548 — Surrogate Endpoint (SUR): Blood pressure
Study 24150782 — Safety Biomarker (SAF): IL-6 and IL-10
Study 16949445 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 19886920 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 10731776 — Predictive Biomarker (PRD): LPP mRNA
Genes: LPP
Study 1390330 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1390330 — Surrogate Endpoint (SUR): Serum sodium
Study 25243340 — Surrogate Endpoint (SUR): Blood pressure
Study 20920825 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 20920825 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 20920825 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 18491170 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9506001 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 9506001 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 9506001 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 3533699 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 27890487 — Surrogate Endpoint (SUR): Blood pressure
Study 27890487 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30285894 — Safety Biomarker (SAF): Interleukin 1
Study 25306750 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 8056701 — Surrogate Endpoint (SUR): Serum creatinine
Study 2973215 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 12500513 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12500513 — Safety Biomarker (SAF): Interleukin 1 alpha
Genes: IL1A; IL1F1
Study 12500513 — Safety Biomarker (SAF): Interleukin 1
Study 12500513 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 12500513 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12500513 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 12500513 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 27513339 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 24344222 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 8694609 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 1746416 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7110969 — Predictive Biomarker (PRD): PRCP mRNA
Genes: PRCP; PCP
Study 27822031 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 7620000 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 25990055 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23857975 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 16522905 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 16522905 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 16522905 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 11109512 — Surrogate Endpoint (SUR): Blood pressure
Study 24554791 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 24554791 — Safety Biomarker (SAF): BDNF
Study 18803639 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 23096708 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 21918160 — Surrogate Endpoint (SUR): Blood pressure
Study 16546738 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12606523 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 29559720 — Surrogate Endpoint (SUR): Blood pressure
Study 12419855 — Predictive Biomarker (PRD): CYCS mRNA
Genes: CYCS; CYC
Study 12419855 — Predictive Biomarker (PRD): GAPDH mRNA
Genes: GAPDH; GAPD; CDABP0047; OK/SW-cl.12
Study 30531477 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 24901546 — Predictive Biomarker (PRD): RAPGEF5 mRNA
Genes: RAPGEF5; GFR; KIAA0277; MRGEF
Study 25750540 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25750540 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9703284 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 28049170 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26482071 — Surrogate Endpoint (SUR): Serum creatinine
Study 2596425 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 23700090 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 21786319 — Surrogate Endpoint (SUR): Bone mineral density
Study 31455425 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 20220185 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20220185 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 31018616 — Predictive Biomarker (PRD): CFP mRNA
Genes: CFP; PFC
Study 22956052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22956052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30779849 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23299384 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 14614780 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 9058216 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19875337 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 12737679 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 31892920 — Predictive Biomarker (PRD): GSC mRNA
Genes: GSC
Study 31892920 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 31892920 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 31492552 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 30972997 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30972997 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30972997 — Surrogate Endpoint (SUR): Blood pressure
Study 30972997 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30972997 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 25620016 — Surrogate Endpoint (SUR): Blood pressure
Study 19663196 — Predictive Biomarker (PRD): BTD mRNA
Genes: BTD
Study 19663196 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 7675298 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 2254759 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 30766533 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 30766533 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 28188670 — Predictive Biomarker (PRD): CPA1 mRNA
Genes: CPA1; CPA
Study 29307087 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 20502135 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17184146 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 15058374 — Surrogate Endpoint (SUR): Probing pocket depth
Study 9135178 — Surrogate Endpoint (SUR): Forced vital capacity
Study 20184043 — Surrogate Endpoint (SUR): Blood pressure
Study 12665489 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10388979 — Surrogate Endpoint (SUR): Blood pressure
Study 10388979 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8777100 — Predictive Biomarker (PRD): AHR mRNA
Genes: AHR; BHLHE76
Study 28355594 — Predictive Biomarker (PRD): NTS mRNA
Genes: NTS
Study 22451437 — Predictive Biomarker (PRD): SERPINA1 mRNA
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209
Study 11286433 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 9451466 — Surrogate Endpoint (SUR): Blood pressure
Study 9451466 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26738450 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25074252 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 22815989 — Surrogate Endpoint (SUR): Blood pressure
Study 22815989 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17300594 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 8567093 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28781130 — Predictive Biomarker (PRD): SH2B3 mRNA
Genes: SH2B3; LNK
Study 25298176 — Surrogate Endpoint (SUR): Blood pressure
Study 25298176 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25298176 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 19300425 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 14767023 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 1933601 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 25354554 — Predictive Biomarker (PRD): RAD51 mRNA
Genes: RAD51; RAD51A; RECA
Study 25354554 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 12827399 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1514532 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31706300 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31706300 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31706300 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21669582 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 21669582 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 12972102 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 6199602 — Surrogate Endpoint (SUR): Blood pressure
Study 26749408 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 1981077 — Surrogate Endpoint (SUR): Blood pressure
Study 21890081 — Surrogate Endpoint (SUR): Blood pressure
Study 21890081 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21890081 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17949458 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17949458 — Safety Biomarker (SAF): IL-6 and IL-10
Study 25577723 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12891539 — Surrogate Endpoint (SUR): Serum creatinine
Study 10492065 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 15931068 — Predictive Biomarker (PRD): TRPA1 mRNA
Genes: TRPA1; ANKTM1
Study 15931068 — Predictive Biomarker (PRD): TRPM8 mRNA
Genes: TRPM8; LTRPC6; TRPP8
Study 10348423 — Surrogate Endpoint (SUR): Blood pressure
Study 7304485 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7304485 — Surrogate Endpoint (SUR): Serum triglycerides
Study 30537138 — Surrogate Endpoint (SUR): Blood pressure
Study 26578734 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 3139279 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 3139279 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH