TrialPanorama/TrialPanorama-database huggingface dataset:
Study 31434390 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 31434390 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7872170 — Surrogate Endpoint (SUR): Blood pressure
Study 26083546 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21592994 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21592994 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21592994 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 21592994 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 21592994 — Safety Biomarker (SAF): Hyaluronic acid
Study 21592994 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21592994 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 21592994 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 15007110 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9868115 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 2904757 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2904757 — Surrogate Endpoint (SUR): Blood pressure
Study 27228002 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 21716297 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17134628 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 25164709 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 20191258 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 18400837 — Predictive Biomarker (PRD): COMP mRNA
Genes: COMP
Study 12584669 — Surrogate Endpoint (SUR): Blood pressure
Study 12584669 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28653377 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28653377 — Safety Biomarker (SAF): IL-6 and IL-10
Study 26362831 — Surrogate Endpoint (SUR): Blood pressure
Study 23232993 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23232993 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11110875 — Predictive Biomarker (PRD): PDXP mRNA
Genes: PDXP; CIN; PLP; PLPP
Study 29067834 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10781481 — Surrogate Endpoint (SUR): Blood pressure
Study 8635674 — Surrogate Endpoint (SUR): Blood pressure
Study 1425867 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 9017770 — Surrogate Endpoint (SUR): Blood pressure
Study 8300456 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30681971 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30681971 — Surrogate Endpoint (SUR): Blood pressure
Study 28659346 — Predictive Biomarker (PRD): AMY1A mRNA
Genes: AMY1A; AMY1
Study 20104985 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 11865364 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 17077058 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 25840952 — Surrogate Endpoint (SUR): Blood pressure
Study 12631177 — Predictive Biomarker (PRD): MAEA mRNA
Genes: MAEA; EMP; HLC10; PIG5
Study 11085964 — Surrogate Endpoint (SUR): Blood pressure
Study 1352732 — Surrogate Endpoint (SUR): Blood pressure
Study 15041568 — Surrogate Endpoint (SUR): Blood pressure
Study 11719730 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 9322139 — Surrogate Endpoint (SUR): Forced vital capacity
Study 8432299 — Surrogate Endpoint (SUR): Blood pressure
Study 30617247 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16406721 — Safety Biomarker (SAF): Hyaluronic acid
Study 12922956 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31504608 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30133134 — Predictive Biomarker (PRD): ABHD14B mRNA
Genes: ABHD14B; CIB
Study 25129333 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 20605898 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 10225243 — Surrogate Endpoint (SUR): Forced vital capacity
Study 10225243 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 1693732 — Surrogate Endpoint (SUR): Blood pressure
Study 23446733 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 23446733 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 3259087 — Surrogate Endpoint (SUR): Blood pressure
Study 31885286 — Pharmacodynamic Biomarker (PDY): Stromal cell-derived factor 1
Genes: CXCL12; SDF1; SDF1A; SDF1B
Study 22858559 — Safety Biomarker (SAF): Cytotoxic T-lymphocyte protein 4
Genes: CTLA4; CD152
Study 10788542 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23901264 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 14610048 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 16468060 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16468060 — Safety Biomarker (SAF): ACE
Genes: ACE1; CD143
Study 1478035 — Surrogate Endpoint (SUR): Serum triglycerides
Study 29506562 — Surrogate Endpoint (SUR): Blood pressure
Study 26599983 — Surrogate Endpoint (SUR): Serum sodium
Study 16463837 — Surrogate Endpoint (SUR): Blood pressure
Study 24856748 — Surrogate Endpoint (SUR): Blood pressure
Study 22562540 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22562540 — Surrogate Endpoint (SUR): Blood pressure
Study 12421195 — Monitoring Biomarker (MOI): Procalcitonin
Study 12421195 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12421195 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12421195 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 25761503 — Predictive Biomarker (PRD): FTO mRNA
Genes: FTO; KIAA1752
Study 21415357 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 26952590 — Surrogate Endpoint (SUR): Blood pressure
Study 23396551 — Surrogate Endpoint (SUR): Blood pressure
Study 20061429 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20061429 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 20061429 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20061429 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11994349 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 9705044 — Surrogate Endpoint (SUR): Blood pressure
Study 688256 — Surrogate Endpoint (SUR): Serum creatinine
Study 31324214 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 23456731 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 23456731 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11888226 — Surrogate Endpoint (SUR): Blood pressure
Study 353464 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 21932579 — Predictive Biomarker (PRD): OMD mRNA
Genes: OMD; SLRR2C; UNQ190/PRO216
Study 11566454 — Surrogate Endpoint (SUR): Serum testosterone
Study 11566454 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29071556 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29071556 — Surrogate Endpoint (SUR): Serum creatinine
Study 29071556 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 29071556 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 27784336 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 27784336 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 27784336 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26084979 — Surrogate Endpoint (SUR): Blood pressure
Study 7949636 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 28121915 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19346845 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 11743460 — Safety Biomarker (SAF): Hyaluronic acid
Study 21939972 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21939972 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21939972 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 21939972 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 21939972 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 18312071 — Safety Biomarker (SAF): Fibroblast growth factor 1
Genes: FGF1
Study 6666215 — Surrogate Endpoint (SUR): Blood pressure
Study 31615840 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 30223252 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 25653511 — Surrogate Endpoint (SUR): Blood pressure
Study 8641482 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 23219537 — Predictive Biomarker (PRD): SEPTIN3 mRNA
Genes: SEPTIN3; SEP3; SEPT3
Study 23219537 — Predictive Biomarker (PRD): SEPTIN6 mRNA
Genes: SEPTIN6; KIAA0128; SEP2; SEPT6
Study 19081791 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9058683 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 28654629 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 16254428 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 14605511 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14605511 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21165861 — Surrogate Endpoint (SUR): Blood pressure
Study 10414418 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 2129490 — Safety Biomarker (SAF): 51Cr-EDTA
Study 27486122 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 9846847 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 9846847 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 1060744 — Predictive Biomarker (PRD): COMP mRNA
Genes: COMP
Study 1060744 — Predictive Biomarker (PRD): POMP mRNA
Genes: POMP; C13orf12; UMP1; HSPC014; HSPC036; PNAS-110
Study 30637662 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29774682 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 23452344 — Pharmacodynamic Biomarker (PDY): Transmembrane glycoprotein NMB
Genes: GPNMB; HGFIN; NMB; UNQ1725/PRO9925
Study 7646097 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 10671187 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 21054754 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 19145785 — Surrogate Endpoint (SUR): Blood pressure
Study 2606855 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 30649238 — Surrogate Endpoint (SUR): Blood pressure
Study 23271170 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26305528 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 26305528 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 26305528 — Safety Biomarker (SAF): Interleukin 1
Study 26305528 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 9556010 — Surrogate Endpoint (SUR): Forced vital capacity
Study 31154664 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18285545 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18285545 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9080244 — Surrogate Endpoint (SUR): Blood pressure
Study 3472450 — Surrogate Endpoint (SUR): Blood pressure
Study 30688673 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 19946034 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 19946034 — Predictive Biomarker (PRD): TNFSF13B mRNA
Genes: TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; UNQ401/PRO738
Study 10501652 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 30286300 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 30286300 — Safety Biomarker (SAF): BDNF
Study 30286300 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12939852 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3296637 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 24851679 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18622504 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12451430 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 12451430 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 8938548 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 1752602 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 22772951 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 9443770 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9443770 — Surrogate Endpoint (SUR): Blood pressure
Study 27520090 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 20877623 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 14510719 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 14510719 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 30017407 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 30017407 — Predictive Biomarker (PRD): WAP four-disulfide core domain protein 2
Genes: WFDC2; HE4; WAP5
Study 19126248 — Surrogate Endpoint (SUR): Blood pressure
Study 29991034 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 27681865 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 27681865 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 27681865 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 27681865 — Predictive Biomarker (PRD): NOTCH1 mRNA
Genes: NOTCH1; TAN1
Study 27681865 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 12740532 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10994885 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 30470592 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 22030240 — Surrogate Endpoint (SUR): Blood pressure
Study 19837920 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 30655198 — Pharmacodynamic Biomarker (PDY): Transmembrane glycoprotein NMB
Genes: GPNMB; HGFIN; NMB; UNQ1725/PRO9925
Study 26717354 — Surrogate Endpoint (SUR): Sperm parameters
Study 26717354 — Safety Biomarker (SAF): Reactive oxygen species
Study 24050803 — Surrogate Endpoint (SUR): Blood pressure
Study 20574413 — Surrogate Endpoint (SUR): Serum uric acid
Study 20574413 — Surrogate Endpoint (SUR): Blood pressure
Study 17967602 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8432776 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 8432776 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 29212825 — Surrogate Endpoint (SUR): Blood pressure
Study 24827969 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 26343552 — Surrogate Endpoint (SUR): Probing pocket depth
Study 31720257 — Surrogate Endpoint (SUR): Blood pressure
Study 31720257 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31720257 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31720257 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 12184060 — Surrogate Endpoint (SUR): Blood pressure
Study 6753911 — Surrogate Endpoint (SUR): Blood pressure
Study 28712074 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 28712074 — Surrogate Endpoint (SUR): Blood pressure
Study 30446894 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 18652757 — Surrogate Endpoint (SUR): Blood pressure
Study 17068384 — Predictive Biomarker (PRD): CDCA3 mRNA
Genes: CDCA3; C8; GRCC8; TOME1
Study 12664247 — Surrogate Endpoint (SUR): Blood pressure
Study 10560170 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 27163519 — Surrogate Endpoint (SUR): Bone mineral density
Study 21459785 — Surrogate Endpoint (SUR): Blood pressure
Study 18089701 — Surrogate Endpoint (SUR): Bone mineral density
Study 16929710 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 12906343 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22176903 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22176903 — Safety Biomarker (SAF): Transforming growth factor beta 1
Genes: TGFB1; TGFB
Study 14597937 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14597937 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10400007 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28352928 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28352928 — Safety Biomarker (SAF): Interleukin 1
Study 23179103 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 18443258 — Surrogate Endpoint (SUR): Blood pressure
Study 18443258 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18443258 — Surrogate Endpoint (SUR): Serum creatinine
Study 10973545 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 8844718 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 6371788 — Surrogate Endpoint (SUR): Serum sodium
Study 24561494 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24561494 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22322521 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22322521 — Surrogate Endpoint (SUR): Blood pressure
Study 8433883 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 16817039 — Surrogate Endpoint (SUR): Bone mineral density
Study 16028129 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16028129 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 1968783 — Surrogate Endpoint (SUR): Blood pressure
Study 31340853 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 30131296 — Predictive Biomarker (PRD): TTN mRNA
Genes: TTN
Study 30131296 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27827358 — Predictive Biomarker (PRD): PIK3CA mRNA
Genes: PIK3CA
Study 27827358 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 27827358 — Predictive Biomarker (PRD): Epithelial cadherin
Genes: CDH1; CDHE; UVO
Study 27827358 — Predictive Biomarker (PRD): KMT2C mRNA
Genes: KMT2C; HALR; KIAA1506; MLL3
Study 27827358 — Predictive Biomarker (PRD): ABCA13 mRNA
Genes: ABCA13
Study 25450275 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 17875063 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10086544 — Surrogate Endpoint (SUR): Blood pressure
Study 10086544 — Surrogate Endpoint (SUR): Serum creatinine
Study 21332628 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21332628 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21332628 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26123683 — Surrogate Endpoint (SUR): Blood pressure
Study 26123683 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 18230228 — Surrogate Endpoint (SUR): Blood pressure
Study 16644785 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12871321 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 22902096 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22902096 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17683650 — Surrogate Endpoint (SUR): Bone mineral density
Study 17683650 — Predictive Biomarker (PRD): Hormone receptor
Study 15896289 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 12585098 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 31362667 — Safety Biomarker (SAF): Thiopurine S-methyltransferase
Genes: TPMT
Study 31362667 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 31362667 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 21827450 — Predictive Biomarker (PRD): TSC22D3 mRNA
Genes: TSC22D3; DSIPI; GILZ
Study 21827450 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): FKBP5 mRNA
Genes: FKBP5; AIG6; FKBP51
Study 9419453 — Predictive Biomarker (PRD): Glutamate carboxypeptidase II
Genes: FOLH1; FOLH; NAALAD1; PSM; PSMA; GIG27
Study 9419453 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 2841251 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2841251 — Surrogate Endpoint (SUR): Blood pressure
Study 31661606 — Predictive Biomarker (PRD): FUT6 mRNA
Genes: FUT6; FCT3A