TrialPanorama/TrialPanorama-database huggingface dataset:
Study 15361892 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2071428 — Surrogate Endpoint (SUR): Blood pressure
Study 31031050 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 26778346 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26778346 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 15341352 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 11180034 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 22930219 — Predictive Biomarker (PRD): CD79A mRNA
Genes: CD79A; IGA; MB1
Study 10657415 — Surrogate Endpoint (SUR): Blood pressure
Study 2878600 — Surrogate Endpoint (SUR): Blood pressure
Study 20159247 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 24457184 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 24457184 — Surrogate Endpoint (SUR): Serum creatinine
Study 20033904 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20033904 — Surrogate Endpoint (SUR): Blood pressure
Study 16357522 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 9024949 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 8510087 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8510087 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31302339 — Predictive Biomarker (PRD): SPX mRNA
Genes: SPX; C12orf39
Study 31302339 — Predictive Biomarker (PRD): BPIFA1 mRNA
Genes: BPIFA1; LUNX; NASG; PLUNC; SPLUNC1; SPURT; UNQ787/PRO1606
Study 26988864 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 12629101 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 27243774 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24485633 — Surrogate Endpoint (SUR): Serum creatinine
Study 20426780 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 12586806 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 10509757 — Predictive Biomarker (PRD): FMO3 mRNA
Genes: FMO3
Study 1753042 — Surrogate Endpoint (SUR): Blood pressure
Study 17293637 — Surrogate Endpoint (SUR): Blood pressure
Study 19539078 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19539078 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19539078 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19402836 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 24360749 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27583475 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24906174 — Surrogate Endpoint (SUR): Blood pressure
Study 22281182 — Pharmacodynamic Biomarker (PDY): Nasal potential difference
Study 16339692 — Predictive Biomarker (PRD): Liver iron
Study 10536647 — Surrogate Endpoint (SUR): Blood pressure
Study 8683231 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 28077379 — Predictive Biomarker (PRD): SFRP1 mRNA
Genes: SFRP1; FRP; FRP1; SARP2
Study 25975969 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12804020 — Surrogate Endpoint (SUR): Blood pressure
Study 12804020 — Surrogate Endpoint (SUR): Serum calcium
Study 19465442 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 19465442 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19465442 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 17525499 — Predictive Biomarker (PRD): CALD1 mRNA
Genes: CALD1; CAD; CDM
Study 15202770 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 23512860 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21545068 — Predictive Biomarker (PRD): REG3A mRNA
Genes: REG3A; HIP; PAP; PAP1
Study 16916429 — Surrogate Endpoint (SUR): Blood pressure
Study 13129464 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 29190004 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 27392509 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 24536058 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22849958 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18199863 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12575908 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 7105826 — Surrogate Endpoint (SUR): Blood pressure
Study 31575569 — Surrogate Endpoint (SUR): Blood pressure
Study 25530465 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 22627477 — Predictive Biomarker (PRD): DDIT4 mRNA
Genes: DDIT4; REDD1; RTP801
Study 17976797 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 17976797 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 8708714 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 30652031 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30652031 — Surrogate Endpoint (SUR): Blood pressure
Study 27835716 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 12235506 — Predictive Biomarker (PRD); Safety Biomarker (SAF): RBPMS mRNA
Genes: RBPMS; HERMES
Study 9698813 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 25486932 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15015704 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 15015704 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 15015704 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 27720136 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HLA-A
Study 27720136 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 21234859 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21234859 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 16189176 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 26763869 — Predictive Biomarker (PRD): DEPP1 mRNA
Genes: DEPP1; C10orf10; DEPP; FIG
Study 12841542 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 12841542 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 12841542 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 10807894 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 8862439 — Predictive Biomarker (PRD): IL11
Genes: IL-11; AGIF
Study 1737653 — Surrogate Endpoint (SUR): Blood pressure
Study 26959509 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20194844 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 16104444 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 1692948 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1692948 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 1692948 — Surrogate Endpoint (SUR): Blood pressure
Study 23845629 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 11467764 — Surrogate Endpoint (SUR): Blood pressure
Study 21823421 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16688999 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29182037 — Predictive Biomarker (PRD): DRD4 mRNA
Genes: DRD4
Study 30177485 — Surrogate Endpoint (SUR): Serum uric acid
Study 30177485 — Surrogate Endpoint (SUR): Serum creatinine
Study 19927154 — Surrogate Endpoint (SUR): Blood pressure
Study 19927154 — Surrogate Endpoint (SUR): Serum creatinine
Study 19927154 — Surrogate Endpoint (SUR): Serum potassium
Study 17621602 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 17621602 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17621602 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 6178096 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 6178096 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 31160658 — Surrogate Endpoint (SUR): Blood pressure
Study 30477855 — Safety Biomarker (SAF): GSTM1
Genes: MU; H-B
Study 26777137 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 9002531 — Surrogate Endpoint (SUR): Serum calcium
Study 9002531 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9002531 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29091464 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29091464 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24269926 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19393996 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 28079773 — Surrogate Endpoint (SUR): Serum triglycerides
Study 28079773 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28079773 — Surrogate Endpoint (SUR): Blood pressure
Study 23532801 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 19276230 — Predictive Biomarker (PRD): STAT5A mRNA
Genes: STAT5A; STAT5
Study 19276230 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 17299377 — Predictive Biomarker (PRD): ARG2 mRNA
Genes: ARG2
Study 17299377 — Predictive Biomarker (PRD): FLT1 mRNA
Genes: FLT1; FLT; FRT; VEGFR1
Study 17299377 — Predictive Biomarker (PRD): HAO2 mRNA
Genes: HAO2; HAOX2; GIG16
Study 17299377 — Predictive Biomarker (PRD): NANOS1 mRNA
Genes: NANOS1; NOS1
Study 15116058 — Predictive Biomarker (PRD): SLCO1B1 mRNA
Genes: SLCO1B1; LST1; OATP1B1; OATP2; OATPC; SLC21A6
Study 3555944 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 3555944 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29509266 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29509266 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29509266 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 29509266 — Safety Biomarker (SAF): Interleukin 1
Study 27605607 — Predictive Biomarker (PRD): MCAT mRNA
Genes: MCAT; MT
Study 23756569 — Safety Biomarker (SAF): Coagulation factor IIa
Genes: F2
Study 20735258 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2857709 — Surrogate Endpoint (SUR): Blood pressure
Study 29022125 — Predictive Biomarker (PRD): ENPP2 mRNA
Genes: ENPP2; ATX; PDNP2
Study 20117403 — Predictive Biomarker (PRD): IL1RL1 mRNA
Genes: IL1RL1; DER4; ST2; T1
Study 10822316 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10822316 — Surrogate Endpoint (SUR): Blood pressure
Study 29289332 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 27280850 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27280850 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25062861 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 23224567 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 23224567 — Predictive Biomarker (PRD): PPA1 mRNA
Genes: PPA1; IOPPP; PP
Study 12928051 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30202916 — Predictive Biomarker (PRD): CHRNA3 mRNA
Genes: CHRNA3; NACHRA3
Study 28477944 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28477944 — Monitoring Biomarker (MOI): Urokinase plasminogen activator surface receptor
Genes: PLAUR; MO3; UPAR
Study 28477944 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1497125 — Surrogate Endpoint (SUR): Blood pressure
Study 27916737 — Predictive Biomarker (PRD): SSB mRNA
Genes: SSB
Study 27326239 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 27326239 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 9458425 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17021319 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 10807815 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 31830776 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 23963057 — Predictive Biomarker (PRD): ENPP2 mRNA
Genes: ENPP2; ATX; PDNP2
Study 19438817 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 22893323 — Safety Biomarker (SAF): Reactive oxygen species
Study 2531992 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 1187279 — Surrogate Endpoint (SUR): Forced vital capacity
Study 30059262 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 20625317 — Surrogate Endpoint (SUR): Blood pressure
Study 2169368 — Surrogate Endpoint (SUR): Blood pressure
Study 28024931 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19138366 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 19138366 — Predictive Biomarker (PRD): ERCC8 mRNA
Genes: ERCC8; CKN1; CSA
Study 15009968 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 16226266 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 26576750 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 22421244 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 29189337 — Surrogate Endpoint (SUR): Blood pressure
Study 2967028 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 26202487 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 10618281 — Predictive Biomarker (PRD): SSB mRNA
Genes: SSB
Study 6199153 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 27144937 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 31331782 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 15720929 — Surrogate Endpoint (SUR): Blood pressure
Study 23550857 — Surrogate Endpoint (SUR): Blood pressure
Study 29427701 — Predictive Biomarker (PRD): ABCA1 mRNA
Genes: ABCA1; ABC1; CERP
Study 29427701 — Predictive Biomarker (PRD): HMGCR mRNA
Genes: HMGCR
Study 29427701 — Predictive Biomarker (PRD): INSIG1 mRNA
Genes: INSIG1
Study 29427701 — Predictive Biomarker (PRD): LDLR mRNA
Genes: LDLR
Study 29427701 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 29427701 — Predictive Biomarker (PRD): SREBF1 mRNA
Genes: SREBF1; BHLHD1; SREBP1
Study 29427701 — Monitoring Biomarker (MOI): miR-29a
Genes: MIR29A
Study 29427701 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): miR-29a-3p
Genes: MIR29A
Study 29427701 — Predictive Biomarker (PRD): miR-106b
Genes: MIR106B
Study 20210906 — Surrogate Endpoint (SUR): Blood pressure
Study 20210906 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20210906 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18156881 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1313761 — Surrogate Endpoint (SUR): Blood pressure
Study 25352870 — Surrogate Endpoint (SUR): Blood pressure
Study 20332612 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 20332612 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 18627368 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 16173137 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 16173137 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 2154513 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12860861 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8890060 — Surrogate Endpoint (SUR): Probing pocket depth
Study 6366617 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 6366617 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 30144169 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15903281 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15903281 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 2540392 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30095747 — Predictive Biomarker (PRD): IL1RN mRNA
Genes: IL1RN; IL1F3; IL1RA
Study 28962661 — Surrogate Endpoint (SUR): Blood pressure
Study 28962661 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28962661 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12587324 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1785245 — Surrogate Endpoint (SUR): Blood pressure
Study 17556705 — Surrogate Endpoint (SUR): Blood pressure
Study 8747858 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 811237 — Surrogate Endpoint (SUR): Forced vital capacity
Study 25331270 — Predictive Biomarker (PRD): RB1
Genes: RB; PPP1R130
Study 15356963 — Surrogate Endpoint (SUR): Serum creatinine
Study 28348182 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 15640382 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15640382 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22448211 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22448211 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22448211 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 9678530 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28705252 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 26179186 — Surrogate Endpoint (SUR): Blood pressure
Study 17483124 — Predictive Biomarker (PRD): GLA
Genes: GALA
Study 2176948 — Surrogate Endpoint (SUR): Blood pressure
Study 25711329 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25711329 — Surrogate Endpoint (SUR): Blood pressure
Study 18430999 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 11061029 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11061029 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8272250 — Surrogate Endpoint (SUR): Blood pressure
Study 2961356 — Surrogate Endpoint (SUR): Serum calcium
Study 12046472 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9851273 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26208996 — Predictive Biomarker (PRD): MIF mRNA
Genes: MIF; GLIF; MMIF
Study 11969062 — Surrogate Endpoint (SUR): Blood pressure
Study 19494532 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 19494532 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 19494532 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17719288 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9660578 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 799567 — Surrogate Endpoint (SUR): Blood pressure
Study 24026211 — Surrogate Endpoint (SUR): Blood pressure
Study 19473611 — Predictive Biomarker (PRD): CNDP2 mRNA
Genes: CNDP2; CN2; CPGL; HEL-S-13; PEPA
Study 19473611 — Predictive Biomarker (PRD): GLS2 mRNA
Genes: GLS2; GA
Study 17950105 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 17950105 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17950105 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 24345886 — Surrogate Endpoint (SUR): Bone mineral density
Study 27614452 — Surrogate Endpoint (SUR): Blood pressure
Study 19280340 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 19280340 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 18629567 — Surrogate Endpoint (SUR): Bone mineral density
Study 16775668 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15030293 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 365212 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 31857621 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31857621 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27023086 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21170108 — Monitoring Biomarker (MOI): HBV DNA
Study 12957262 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 30309994 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 25275513 — Predictive Biomarker (PRD): SLPI mRNA
Genes: SLPI; WAP4; WFDC4