TrialPanorama/TrialPanorama-database huggingface dataset:
Study 14624421 — Surrogate Endpoint (SUR): Serum creatinine
Study 29282574 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27697758 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 24241095 — Surrogate Endpoint (SUR): Serum creatinine
Study 2232062 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2232062 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 14993491 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 2853749 — Surrogate Endpoint (SUR): Blood pressure
Study 24050942 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 24050942 — Surrogate Endpoint (SUR): Blood pressure
Study 21144559 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 8956793 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 30615058 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30615058 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30615058 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29373094 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 27179795 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 24193112 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 8179134 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 28800722 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 24028716 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24028716 — Predictive Biomarker (PRD): FOXP3 mRNA
Genes: FOXP3; IPEX; JM2
Study 14985213 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 14985213 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11687731 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11687731 — Surrogate Endpoint (SUR): Blood pressure
Study 24699939 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24699939 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21316934 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21316934 — Surrogate Endpoint (SUR): Blood pressure
Study 9920100 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7484282 — Surrogate Endpoint (SUR): Bone mineral density
Study 2301454 — Surrogate Endpoint (SUR): Blood pressure
Study 22653877 — Predictive Biomarker (PRD): SLC46A1 mRNA
Genes: SLC46A1; G21; HCP1; PCFT
Study 2663695 — Monitoring Biomarker (MOI): HBV DNA
Study 26437761 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 21248158 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 31538282 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 28741805 — Predictive Biomarker (PRD): INPP5J mRNA
Genes: INPP5J; PIB5PA; PIPP
Study 22976217 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 11258039 — Surrogate Endpoint (SUR): Blood pressure
Study 19625372 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19625372 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19625372 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19625372 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9786562 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Neurofilament light polypeptide
Genes: NEFL; NF68; NFL
Study 7837398 — Surrogate Endpoint (SUR): Blood pressure
Study 14687246 — Surrogate Endpoint (SUR): Serum calcium
Study 11398072 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 23835245 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23835245 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23835245 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21592110 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 9246969 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 9246969 — Surrogate Endpoint (SUR): Serum creatinine
Study 31704159 — Surrogate Endpoint (SUR): Blood pressure
Study 29258541 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26265274 — Surrogate Endpoint (SUR): Blood pressure
Study 8087360 — Predictive Biomarker (PRD): DDR1 mRNA
Genes: DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE
Study 2697584 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 24136634 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 21654506 — Predictive Biomarker (PRD): MECP2 mRNA
Genes: MECP2
Study 8229908 — Surrogate Endpoint (SUR): Blood pressure
Study 26290275 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26290275 — Surrogate Endpoint (SUR): Blood pressure
Study 21224376 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 21224376 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21224376 — Predictive Biomarker (PRD): FLT1 mRNA
Genes: FLT1; FLT; FRT; VEGFR1
Study 21224376 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 21224376 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 16199916 — Surrogate Endpoint (SUR): Blood pressure
Study 11980131 — Surrogate Endpoint (SUR): Blood pressure
Study 27912934 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 23954450 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18262663 — Safety Biomarker (SAF): DRD3
Study 23070486 — Safety Biomarker (SAF): Interleukin 1
Study 21073556 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 21073556 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 9852390 — Surrogate Endpoint (SUR): Bone mineral density
Study 9852390 — Surrogate Endpoint (SUR): Serum calcium
Study 23706946 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 23706946 — Predictive Biomarker (PRD): HTRA1 mRNA
Genes: HTRA1; HTRA; PRSS11
Study 23706946 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 19080748 — Surrogate Endpoint (SUR): Blood pressure
Study 9602314 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 24783193 — Predictive Biomarker (PRD): LOX mRNA
Genes: LOX
Study 24783193 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24783193 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 9278463 — Surrogate Endpoint (SUR): Bone mineral density
Study 16770291 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23647738 — Predictive Biomarker (PRD): TYR mRNA
Genes: TYR
Study 23647738 — Predictive Biomarker (PRD): ABL2 mRNA
Genes: ABL2; ABLL; ARG
Study 18617304 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 8439021 — Predictive Biomarker (PRD): DAP mRNA
Genes: DAP; DAP1
Study 26827289 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 11943529 — Surrogate Endpoint (SUR): Blood pressure
Study 241365 — Surrogate Endpoint (SUR): Blood pressure
Study 24961537 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20441243 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 20441243 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20441243 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 20441243 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 1899823 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 30634590 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22752690 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 15084930 — Surrogate Endpoint (SUR): Serum creatinine
Study 15084930 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 15084930 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15084930 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 313717 — Safety Biomarker (SAF): Succinate dehydrogenase
Genes: SDHD
Study 31023272 — Surrogate Endpoint (SUR): Blood pressure
Study 31023272 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 25540059 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 22528588 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 19008491 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19008491 — Safety Biomarker (SAF): Reactive oxygen species
Study 19008491 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19008491 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 11716313 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11716313 — Surrogate Endpoint (SUR): Blood pressure
Study 11716313 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27860410 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27860410 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25459913 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Sclerostin
Genes: SOST; UNQ2976/PRO7455/PRO7476
Study 19041436 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19041436 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25886378 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 21480416 — Safety Biomarker (SAF): Reactive oxygen species
Study 21480416 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 2864374 — Surrogate Endpoint (SUR): Blood pressure
Study 27664491 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 22124524 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 26871245 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26871245 — Surrogate Endpoint (SUR): Blood pressure
Study 22006544 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15470286 — Surrogate Endpoint (SUR): Blood pressure
Study 24594863 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24594863 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24594863 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31829793 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 31829793 — Safety Biomarker (SAF): Reactive oxygen species
Study 31829793 — Safety Biomarker (SAF): BDNF
Study 19649309 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19649309 — Surrogate Endpoint (SUR): Blood pressure
Study 9601649 — Predictive Biomarker (PRD): CA1 mRNA
Genes: CA1
Study 7721516 — Surrogate Endpoint (SUR): Blood pressure
Study 7721516 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23893223 — Surrogate Endpoint (SUR): Blood pressure
Study 12972684 — Surrogate Endpoint (SUR): Blood pressure
Study 12972684 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9101374 — Surrogate Endpoint (SUR): Bone mineral density
Study 24705678 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 25649195 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 11583720 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11583720 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25539931 — Surrogate Endpoint (SUR): Blood pressure
Study 24166760 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 7796569 — Predictive Biomarker (PRD): CENPJ mRNA
Genes: CENPJ; CPAP; LAP; LIP1
Study 28045335 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 28045335 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 14769702 — Predictive Biomarker (PRD): ABCG5 mRNA
Genes: ABCG5
Study 26386635 — Predictive Biomarker (PRD): EBF1 mRNA
Genes: EBF1; COE1; EBF
Study 11745278 — Predictive Biomarker (PRD): Hormone receptor
Study 9052812 — Predictive Biomarker (PRD): CNTF mRNA
Genes: CNTF
Study 9052812 — Surrogate Endpoint (SUR): Forced vital capacity
Study 21745832 — Predictive Biomarker (PRD): GSS mRNA
Genes: GSS
Study 26743526 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17615501 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 12616822 — Monitoring Biomarker (MOI): Procalcitonin
Study 12616822 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21228267 — Predictive Biomarker (PRD): CFTR
Genes: MRP7; ABC35; TNR-CFTR; dJ760C5.1; CFTR/MRP
Study 19098076 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8839196 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 1451816 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 2874067 — Surrogate Endpoint (SUR): Blood pressure
Study 2874067 — Surrogate Endpoint (SUR): Serum creatinine
Study 24329506 — Surrogate Endpoint (SUR): Bone mineral density
Study 409101 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 30291545 — Predictive Biomarker (PRD): THBS1 mRNA
Genes: THBS1; TSP; TSP1
Study 19330600 — Surrogate Endpoint (SUR): Blood pressure
Study 28131433 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 28395507 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 26627878 — Surrogate Endpoint (SUR): Blood pressure
Study 2853406 — Surrogate Endpoint (SUR): Blood pressure
Study 16335682 — Surrogate Endpoint (SUR): Bone mineral density
Study 22035826 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 17071205 — Surrogate Endpoint (SUR): Serum calcium
Study 21625881 — Surrogate Endpoint (SUR): Bone mineral density
Study 18630772 — Surrogate Endpoint (SUR): Blood pressure
Study 1787609 — Predictive Biomarker (PRD): CHAF1A mRNA
Genes: CHAF1A; CAF; CAF1P150
Study 7019839 — Surrogate Endpoint (SUR): Forced vital capacity
Study 21135055 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 11777489 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 9258415 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27733375 — Predictive Biomarker (PRD): HMBS mRNA
Genes: HMBS; PBGD; UPS
Study 11867404 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11867404 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 11867404 — Surrogate Endpoint (SUR): Blood pressure
Study 24691248 — Predictive Biomarker (PRD): PLB1 mRNA
Genes: PLB1; PLB
Study 7585063 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 7585063 — Safety Biomarker (SAF): DRD2
Study 10532692 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2284219 — Surrogate Endpoint (SUR): Serum creatinine
Study 7457801 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 26970404 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 28792851 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28792851 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28792851 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24146218 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 29029101 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15297066 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 24793528 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 8021054 — Surrogate Endpoint (SUR): Blood pressure
Study 21983163 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21983163 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21983163 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21983163 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18445991 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 25244260 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16438016 — Surrogate Endpoint (SUR): Blood pressure
Study 29465346 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29465346 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29465346 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27344118 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 7688829 — Surrogate Endpoint (SUR): Serum luteinizing hormone
Study 7688829 — Surrogate Endpoint (SUR): Serum testosterone
Study 28329346 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 28329346 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 17623225 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31219734 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15988706 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15988706 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7815337 — Surrogate Endpoint (SUR): Blood pressure
Study 24517155 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 17559146 — Safety Biomarker (SAF): Dihydrothymine dehydrogenase
Genes: DPYD
Study 16293862 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16293862 — Predictive Biomarker (PRD): Hormone receptor
Study 9542477 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 2646839 — Surrogate Endpoint (SUR): Blood pressure
Study 28662049 — Surrogate Endpoint (SUR): Probing pocket depth
Study 26199386 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 22228829 — Predictive Biomarker (PRD): HTR2A mRNA
Genes: HTR2A; HTR2
Study 22228829 — Predictive Biomarker (PRD): HTR2C mRNA
Genes: HTR2C; HTR1C
Study 22228829 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 22228829 — Safety Biomarker (SAF): BDNF
Study 15076170 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 15076170 — Surrogate Endpoint (SUR): Blood pressure
Study 27855103 — Safety Biomarker (SAF): Hyaluronic acid
Study 25336055 — Surrogate Endpoint (SUR): Blood pressure
Study 17962632 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 1410588 — Surrogate Endpoint (SUR): Blood pressure
Study 2676659 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31429198 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26223240 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 17250464 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 17250464 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 15736476 — Predictive Biomarker (PRD): SERPINA6 mRNA
Genes: SERPINA6; CBG
Study 12062150 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 7783410 — Surrogate Endpoint (SUR): Serum creatinine
Study 27860389 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27860389 — Surrogate Endpoint (SUR): Blood pressure
Study 27860389 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 9681721 — Safety Biomarker (SAF): Interleukin 1
Study 31725319 — Surrogate Endpoint (SUR): Blood pressure
Study 17074775 — Surrogate Endpoint (SUR): Blood pressure
Study 17074775 — Surrogate Endpoint (SUR): Serum creatinine
Study 9258853 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 28365177 — Surrogate Endpoint (SUR): Bone mineral density
Study 3538802 — Surrogate Endpoint (SUR): Blood pressure
Study 12953018 — Surrogate Endpoint (SUR): Blood pressure
Study 10844829 — Surrogate Endpoint (SUR): Blood pressure
Study 30408621 — Surrogate Endpoint (SUR): Blood pressure
Study 20068208 — Predictive Biomarker (PRD): MAVS mRNA
Genes: MAVS; IPS1; KIAA1271; VISA
Study 8641322 — Predictive Biomarker (PRD): DDR1 mRNA
Genes: DDR1; CAK; EDDR1; NEP; NTRK4; PTK3A; RTK6; TRKE
Study 8641322 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 8641322 — Surrogate Endpoint (SUR): Blood pressure
Study 2138704 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2138704 — Surrogate Endpoint (SUR): Blood pressure
Study 6158390 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 25981651 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 18997196 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1