TrialPanorama/TrialPanorama-database huggingface dataset:
Study 29977328 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Mitochondrial DNA
Study 27960614 — Predictive Biomarker (PRD): NOS2 mRNA
Genes: NOS2; NOS2A
Study 7988180 — Surrogate Endpoint (SUR): Serum potassium
Study 3054048 — Surrogate Endpoint (SUR): Probing pocket depth
Study 21274882 — Predictive Biomarker (PRD): REG3A mRNA
Genes: REG3A; HIP; PAP; PAP1
Study 21274882 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21274882 — Safety Biomarker (SAF): Reactive oxygen species
Study 29603684 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29603684 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 11171788 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27974307 — Predictive Biomarker (PRD): HGS mRNA
Genes: HGS; HRS
Study 29194765 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 27559981 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 15824212 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 15824212 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8029260 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 23459753 — Predictive Biomarker (PRD): SLC38A2 mRNA
Genes: SLC38A2; ATA2; KIAA1382; SAT2; SNAT2
Study 17123204 — Predictive Biomarker (PRD): BBC3 mRNA
Genes: BBC3; PUMA
Study 12827582 — Surrogate Endpoint (SUR): Blood pressure
Study 9373227 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15983677 — Predictive Biomarker (PRD): KCNN1 mRNA
Genes: KCNN1; SK
Study 22116464 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 11592727 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 9481526 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22796405 — Predictive Biomarker (PRD): OSCAR mRNA
Genes: OSCAR
Study 7636755 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 81361 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 31004128 — Predictive Biomarker (PRD): WWTR1 mRNA
Genes: WWTR1; TAZ
Study 10396705 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2103060 — Predictive Biomarker (PRD): DAP mRNA
Genes: DAP; DAP1
Study 2103060 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15848482 — Surrogate Endpoint (SUR): Serum creatinine
Study 12070058 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 12070058 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30222235 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 31725655 — Predictive Biomarker (PRD): GFAP mRNA
Genes: GFAP
Study 17405586 — Surrogate Endpoint (SUR): Blood pressure
Study 7572012 — Surrogate Endpoint (SUR): Blood pressure
Study 2144295 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 2144295 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2144295 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 31120908 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31120908 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31120908 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Mitochondrial DNA
Study 27837439 — Surrogate Endpoint (SUR): Serum sodium
Study 25613307 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 30920571 — Predictive Biomarker (PRD): NPC1L1 mRNA
Genes: NPC1L1
Study 8226485 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 28406860 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 26946952 — Surrogate Endpoint (SUR): Blood pressure
Study 23540683 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 7893268 — Surrogate Endpoint (SUR): Blood pressure
Study 12393276 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 12393276 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 23396142 — Predictive Biomarker (PRD): LIFR mRNA
Genes: LIFR
Study 23396142 — Safety Biomarker (SAF): miR-140
Genes: MIR140
Study 23396142 — Safety Biomarker (SAF): miR-142
Genes: MIR142
Study 23396142 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-125b
Study 23396142 — Safety Biomarker (SAF): miR-15a
Genes: MIR15A
Study 23396142 — Safety Biomarker (SAF): miR-423
Genes: MIR423
Study 23396142 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-122
Genes: MIR122
Study 23396142 — Safety Biomarker (SAF): miR-16
Study 9562581 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 24216543 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 20224285 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 14756017 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1372668 — Predictive Biomarker (PRD): ITGB2 mRNA
Genes: ITGB2; CD18; MFI7
Study 31578173 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 24383843 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 24383843 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 22828088 — Surrogate Endpoint (SUR): Blood pressure
Study 17611565 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 31070709 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 30101416 — Safety Biomarker (SAF): Hyaluronic acid
Study 31001633 — Predictive Biomarker (PRD): MPL mRNA
Genes: MPL; TPOR
Study 20530591 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 19861667 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 11817713 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 31037967 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 19091800 — Surrogate Endpoint (SUR): Blood pressure
Study 9789914 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2680272 — Surrogate Endpoint (SUR): Blood pressure
Study 23219613 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 10714852 — Surrogate Endpoint (SUR): Blood pressure
Study 8985717 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 8985717 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 27938853 — Surrogate Endpoint (SUR): Blood pressure
Study 27938853 — Surrogate Endpoint (SUR): Serum uric acid
Study 10634389 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30476246 — Surrogate Endpoint (SUR): Bone mineral density
Study 30476246 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30476246 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25399733 — Surrogate Endpoint (SUR): Blood pressure
Study 25399733 — Surrogate Endpoint (SUR): Total kidney volume
Study 25399733 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19762332 — Predictive Biomarker (PRD): MVP mRNA
Genes: MVP; LRP
Study 20585342 — Predictive Biomarker (PRD): GATA4 mRNA
Genes: GATA4
Study 20585342 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 9610900 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 9610900 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 26966867 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 25487431 — Surrogate Endpoint (SUR): Blood pressure
Study 30416026 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30416026 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 14530809 — Predictive Biomarker (PRD): Hormone receptor
Study 8181328 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24968966 — Surrogate Endpoint (SUR): Blood pressure
Study 18691861 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10708933 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 30701736 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 11126034 — Surrogate Endpoint (SUR): Blood pressure
Study 1388878 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 3902200 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 16461961 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29723339 — Pharmacodynamic Biomarker (PDY): Platelet-derived growth factor B
Genes: PDGFB; PDGF2; SIS
Study 16497687 — Surrogate Endpoint (SUR): Blood pressure
Study 14600550 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 26997623 — Surrogate Endpoint (SUR): Blood pressure
Study 26997623 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20581351 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20581351 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 20581351 — Safety Biomarker (SAF): Reactive oxygen species
Study 31533151 — Safety Biomarker (SAF): Hyaluronic acid
Study 17317184 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 17317184 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 27831492 — Surrogate Endpoint (SUR): Blood pressure
Study 26608649 — Surrogate Endpoint (SUR): Bone mineral density
Study 18499600 — Surrogate Endpoint (SUR): Blood pressure
Study 20406576 — Predictive Biomarker (PRD): GARS1 mRNA
Genes: GARS1; GARS
Study 27378086 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 16015255 — Surrogate Endpoint (SUR): Serum triglycerides
Study 12551869 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31452425 — Predictive Biomarker (PRD): PNN mRNA
Genes: PNN; DRS; MEMA
Study 11486442 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11486442 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 31022403 — Surrogate Endpoint (SUR): Blood pressure
Study 28669885 — Surrogate Endpoint (SUR): Blood pressure
Study 22994935 — Surrogate Endpoint (SUR): Bone mineral density
Study 18413439 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 18413439 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9806676 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 29442459 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 16491317 — Surrogate Endpoint (SUR): Blood pressure
Study 19157102 — Surrogate Endpoint (SUR): Serum creatinine
Study 14712886 — Surrogate Endpoint (SUR): Blood pressure
Study 21781528 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 17126116 — Surrogate Endpoint (SUR): Serum creatinine
Study 11438417 — Predictive Biomarker (PRD): TWIST1 mRNA
Genes: TWIST1; BHLHA38; TWIST
Study 9150331 — Surrogate Endpoint (SUR): Forced vital capacity
Study 8429112 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8429112 — Surrogate Endpoint (SUR): Blood pressure
Study 8833174 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8833174 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 8833174 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29889764 — Surrogate Endpoint (SUR): Bone mineral density
Study 27015283 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24692050 — Surrogate Endpoint (SUR): Bone mineral density
Study 8002535 — Predictive Biomarker (PRD): CORT mRNA
Genes: CORT; UNQ307/PRO350
Study 28732324 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 23427334 — Predictive Biomarker (PRD): KITLG mRNA
Genes: KITLG; MGF; SCF
Study 24324046 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 30311085 — Surrogate Endpoint (SUR): Bacterial count
Study 20329605 — Surrogate Endpoint (SUR): Serum uric acid
Study 28608165 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 26243374 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 22905856 — Surrogate Endpoint (SUR): Serum creatinine
Study 12860551 — Surrogate Endpoint (SUR): Bone mineral density
Study 9259041 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 27181566 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 24798870 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): CCR2 mRNA
Genes: CCR2; CMKBR2
Study 22695756 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 22695756 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 20484175 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 7626318 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31742316 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 31742316 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 31742316 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 31742316 — Predictive Biomarker (PRD): NTM mRNA
Genes: NTM; IGLON2; NT; UNQ297/PRO337
Study 26071975 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26071975 — Surrogate Endpoint (SUR): Blood pressure
Study 21917762 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 21917762 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 19853690 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27863609 — Surrogate Endpoint (SUR): Blood pressure
Study 18555933 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 15473116 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23658561 — Surrogate Endpoint (SUR): Blood pressure
Study 16117969 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 10760830 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 31667338 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31667338 — Predictive Biomarker (PRD): Hormone receptor
Study 31667338 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 18664319 — Predictive Biomarker (PRD): FMOD mRNA
Genes: FMOD; FM; SLRR2E
Study 10931021 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19454638 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 12238641 — Surrogate Endpoint (SUR): Serum triglycerides
Study 12238641 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 10443645 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7805238 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 2129678 — Surrogate Endpoint (SUR): Blood pressure
Study 7043175 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7043175 — Surrogate Endpoint (SUR): Blood pressure
Study 31764094 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8772218 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 23413906 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20938778 — Predictive Biomarker (PRD): C1QL1 mRNA
Genes: C1QL1; C1QRF; CRF; CTRP14
Study 19807760 — Safety Biomarker (SAF): Hyaluronic acid
Study 17325686 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 11848167 — Surrogate Endpoint (SUR): Blood pressure
Study 31840162 — Surrogate Endpoint (SUR): Serum uric acid
Study 31840162 — Surrogate Endpoint (SUR): Blood pressure
Study 29789393 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 25317990 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 22228146 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 18557715 — Surrogate Endpoint (SUR): Serum creatinine
Study 6352119 — Surrogate Endpoint (SUR): Blood pressure
Study 21920481 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16083541 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16083541 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12372444 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 7586108 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29607525 — Surrogate Endpoint (SUR): Blood pressure
Study 29607525 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12827578 — Safety Biomarker (SAF): Reactive oxygen species
Study 12827578 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 9766154 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27355239 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 24796766 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 23174579 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 20236550 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20236550 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 18608197 — Surrogate Endpoint (SUR): Blood pressure
Study 28503826 — Surrogate Endpoint (SUR): Pathological complete response
Study 25910950 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 25910950 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 25910950 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 14975456 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 28813433 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 25573400 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 12513914 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 12513914 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17611340 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 12052481 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 31222796 — Predictive Biomarker (PRD): CYP2E1 mRNA
Genes: CYP2E1; CYP2E
Study 31222796 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 17650790 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 14738236 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9695720 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 21457668 — Surrogate Endpoint (SUR): Blood pressure
Study 29167485 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 21680781 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 15200445 — Surrogate Endpoint (SUR): Blood pressure
Study 8500917 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Trefoil factor 3
Genes: TFF3; ITF; TFI
Study 28090293 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 22084312 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DAND5 mRNA
Genes: DAND5; CER2; CKTSF1B3; GREM3; SP1
Study 8873694 — Surrogate Endpoint (SUR): Blood pressure
Study 28726810 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 27316679 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27316679 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17522603 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 2422744 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 26508298 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 11961025 — Surrogate Endpoint (SUR): Serum creatinine
Study 7553634 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 7553634 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7553634 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7553634 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 23452523 — Surrogate Endpoint (SUR): Blood pressure
Study 14618645 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 14618645 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 1320259 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30964750 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27456983 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22310542 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7734104 — Surrogate Endpoint (SUR): Blood pressure
Study 31469816 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 28492860 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 28492860 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 9763798 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7812072 — Surrogate Endpoint (SUR): Bone mineral density
Study 20693809 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10192656 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 10192656 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 12480822 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 16139123 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2189903 — Surrogate Endpoint (SUR): Blood pressure
Study 24113783 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 24113783 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 11106884 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 6129933 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 6129933 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 31471504 — Surrogate Endpoint (SUR): Blood pressure