TrialPanorama/TrialPanorama-database huggingface dataset:
Study 2508850 — Monitoring Biomarker (MOI): HBV DNA
Study 31845191 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 31845191 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 28483015 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 15316867 — Surrogate Endpoint (SUR): Bone mineral density
Study 4006240 — Surrogate Endpoint (SUR): Blood pressure
Study 22025606 — Predictive Biomarker (PRD): OAT mRNA
Genes: OAT
Study 1384845 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 26772193 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26772193 — Safety Biomarker (SAF): IL-6 and IL-10
Study 18509786 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 18509786 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 18509786 — Surrogate Endpoint (SUR): Blood pressure
Study 9609358 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 2797920 — Surrogate Endpoint (SUR): Forced vital capacity
Study 25275318 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 25275318 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 25275318 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25275318 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17978591 — Surrogate Endpoint (SUR): Blood pressure
Study 17978591 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9627359 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 9627359 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26848570 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 26848570 — Surrogate Endpoint (SUR): Serum uric acid
Study 26472571 — Surrogate Endpoint (SUR): Blood pressure
Study 22078985 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29117576 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 16115731 — Pharmacodynamic Biomarker (PDY): Leucine-rich repeat kinase 2
Genes: LRRK2; PARK8
Study 12106929 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 2555105 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 2555105 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 2555105 — Safety Biomarker (SAF): Cytochrome c
Study 10694109 — Surrogate Endpoint (SUR): Blood pressure
Study 1912554 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 17543680 — Predictive Biomarker (PRD): ASL mRNA
Genes: ASL
Study 17543680 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 28843974 — Surrogate Endpoint (SUR): Blood pressure
Study 26836910 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 10425301 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 2138974 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 111275 — Surrogate Endpoint (SUR): Blood pressure
Study 30615024 — Predictive Biomarker (PRD): SGCA mRNA
Genes: SGCA; ADL; DAG2
Study 26298619 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 7503516 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7503516 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31703648 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 31703648 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 25377269 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24088225 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 24088225 — Safety Biomarker (SAF): RAS pathway
Study 20196388 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8088068 — Surrogate Endpoint (SUR): Blood pressure
Study 8088068 — Surrogate Endpoint (SUR): Serum creatinine
Study 16029627 — Predictive Biomarker (PRD): GAPDH mRNA
Genes: GAPDH; GAPD; CDABP0047; OK/SW-cl.12
Study 10452405 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27593381 — Predictive Biomarker (PRD): AGA mRNA
Genes: AGA
Study 12585146 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30264918 — Predictive Biomarker (PRD): TPO mRNA
Genes: TPO
Study 21042763 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 14740952 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 11167770 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 21329027 — Surrogate Endpoint (SUR): Forced vital capacity
Study 241598 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26089332 — Surrogate Endpoint (SUR): Blood pressure
Study 24725967 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 11705788 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 9626922 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 7829693 — Surrogate Endpoint (SUR): Serum calcium
Study 3050188 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 27243353 — Safety Biomarker (SAF): Hyaluronic acid
Study 24111258 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 17535867 — Surrogate Endpoint (SUR): Serum testosterone
Study 10195532 — Surrogate Endpoint (SUR): Blood pressure
Study 2405108 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31776782 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 31566579 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31566579 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 23331559 — Predictive Biomarker (PRD): LTB mRNA
Genes: LTB; TNFC; TNFSF3
Study 22353410 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 16400056 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15380045 — Predictive Biomarker (PRD): COMP mRNA
Genes: COMP
Study 15380045 — Surrogate Endpoint (SUR): Bone mineral density
Study 23523222 — Surrogate Endpoint (SUR): Bacterial count
Study 19920426 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 19920426 — Surrogate Endpoint (SUR): Forced vital capacity
Study 16512478 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 16512478 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 10943872 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 10943872 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 10943872 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10943872 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10943872 — Monitoring Biomarker (MOI): Matrix metalloproteinase 1
Genes: MMP1; CLG
Study 10943872 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 9301427 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3275752 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 29401246 — Predictive Biomarker (PRD): WAP four-disulfide core domain protein 2
Genes: WFDC2; HE4; WAP5
Study 26738271 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 26738271 — Surrogate Endpoint (SUR): Blood pressure
Study 26738271 — Surrogate Endpoint (SUR): Serum uric acid
Study 2905154 — Surrogate Endpoint (SUR): Blood pressure
Study 8989735 — Surrogate Endpoint (SUR): Blood pressure
Study 22775763 — Surrogate Endpoint (SUR): Blood pressure
Study 22775763 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15615808 — Surrogate Endpoint (SUR): Blood pressure
Study 3043077 — Surrogate Endpoint (SUR): Serum creatinine
Study 31931927 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31931927 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31931927 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31931927 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31931927 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12213435 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 9835004 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 7730602 — Surrogate Endpoint (SUR): Blood pressure
Study 2521409 — Surrogate Endpoint (SUR): Serum creatinine
Study 23480456 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21619984 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 15223872 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 23751277 — Predictive Biomarker (PRD): SLCO2B1 mRNA
Genes: SLCO2B1; KIAA0880; OATP2B1; OATPB; SLC21A9
Study 23751277 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 23751277 — Predictive Biomarker (PRD): ABCG2 mRNA
Genes: ABCG2; ABCP; BCRP; BCRP1; MXR
Study 21281870 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10676602 — Surrogate Endpoint (SUR): Blood pressure
Study 10676602 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24970869 — Surrogate Endpoint (SUR): Serum calcium
Study 18688081 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 18688081 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 18688081 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 6377563 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30315178 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30315178 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7720759 — Surrogate Endpoint (SUR): Blood pressure
Study 8800784 — Surrogate Endpoint (SUR): Bone mineral density
Study 23290081 — Predictive Biomarker (PRD): EDNRA mRNA
Genes: EDNRA; ETA; ETRA
Study 17031013 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 9314645 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 31206501 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 29457585 — Predictive Biomarker (PRD): ID1 mRNA
Genes: ID1; BHLHB24; ID
Study 23453439 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 19938199 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16934043 — Surrogate Endpoint (SUR): Blood pressure
Study 12628875 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 21982583 — Predictive Biomarker (PRD): CXADR mRNA
Genes: CXADR; CAR
Study 9613910 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9613910 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22088587 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 22088587 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 22088587 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22088587 — Safety Biomarker (SAF): BDNF
Study 17143357 — Predictive Biomarker (PRD): ABO mRNA
Genes: ABO
Study 8200722 — Safety Biomarker (SAF): N-acetylneuraminic acid
Study 30349279 — Surrogate Endpoint (SUR): Blood pressure
Study 22491963 — Predictive Biomarker (PRD): MT2A mRNA
Genes: MT2A; CES1; MT2
Study 20634736 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 18576898 — Surrogate Endpoint (SUR): Blood pressure
Study 31049826 — Predictive Biomarker (PRD): NF2 mRNA
Genes: NF2; SCH
Study 19149817 — Surrogate Endpoint (SUR): Blood pressure
Study 15159498 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 31416745 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31416745 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29259181 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 7530641 — Predictive Biomarker (PRD): EBPL mRNA
Genes: EBPL; EBRP; ERP
Study 2212968 — Surrogate Endpoint (SUR): Blood pressure
Study 16461038 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6153834 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 31377905 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31377905 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25336921 — Surrogate Endpoint (SUR): Blood pressure
Study 15661417 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 15661417 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 10087242 — Surrogate Endpoint (SUR): Bone mineral density
Study 7018726 — Predictive Biomarker (PRD): MERTK mRNA
Genes: MERTK; MER
Study 29084522 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 29084522 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23637005 — Predictive Biomarker (PRD): TPO mRNA
Genes: TPO
Study 1509550 — Surrogate Endpoint (SUR): Blood pressure
Study 6838691 — Surrogate Endpoint (SUR): Blood pressure
Study 24949549 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 14996412 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 14996412 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 31424395 — Pharmacodynamic Biomarker (PDY): Beta-secretase 1
Genes: BACE1; BACE; KIAA1149
Study 19141998 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19141998 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19141998 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12351466 — Surrogate Endpoint (SUR): Blood pressure
Study 31865042 — Predictive Biomarker (PRD): HOXA9 mRNA
Genes: HOXA9; HOX1G
Study 19523690 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 28653586 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28653586 — Surrogate Endpoint (SUR): Blood pressure
Study 24224449 — Safety Biomarker (SAF): Reactive oxygen species
Study 3742049 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 28480658 — Surrogate Endpoint (SUR): Bone mineral density
Study 19383314 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 9795483 — Surrogate Endpoint (SUR): Blood pressure
Study 365214 — Surrogate Endpoint (SUR): Forced vital capacity
Study 26620101 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 26620101 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 22212862 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15221206 — Surrogate Endpoint (SUR): Bone mineral density
Study 21471564 — Predictive Biomarker (PRD): Tubulin beta-3 chain
Genes: TUBB3; TUBB4
Study 15220243 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 15220243 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 15220243 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 15220243 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27568322 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 27568322 — Predictive Biomarker (PRD): MTOR mRNA
Genes: MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Study 27568322 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 27568322 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 20018286 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20018286 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18600215 — Surrogate Endpoint (SUR): Blood pressure
Study 2870352 — Surrogate Endpoint (SUR): Blood pressure
Study 2870352 — Surrogate Endpoint (SUR): Serum potassium
Study 24827746 — Predictive Biomarker (PRD): GNB3 mRNA
Genes: GNB3
Study 24827746 — Predictive Biomarker (PRD): ADRB3 mRNA
Genes: ADRB3; ADRB3R; B3AR
Study 24827746 — Predictive Biomarker (PRD): UCP2 mRNA
Genes: UCP2; SLC25A8
Study 20590587 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 20590587 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 7734262 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 6940435 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30823948 — Predictive Biomarker (PRD): LIF mRNA
Genes: LIF; HILDA
Study 21334912 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 21334912 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 21334912 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 2973219 — Surrogate Endpoint (SUR): Serum triglycerides
Study 2973219 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29925472 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16023653 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16023653 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 16023653 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8889902 — Surrogate Endpoint (SUR): Blood pressure
Study 1988237 — Surrogate Endpoint (SUR): Blood pressure
Study 31797203 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 31797203 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 31797203 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31797203 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 25970861 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 23660169 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17513945 — Surrogate Endpoint (SUR): Blood pressure
Study 31007226 — Surrogate Endpoint (SUR): Blood pressure
Study 25072610 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 25072610 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7631732 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 23222034 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 18155052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18155052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9008448 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23935398 — Safety Biomarker (SAF): Urinary microalbumin
Study 23935398 — Surrogate Endpoint (SUR): Blood pressure
Study 10733537 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 22339102 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 16207547 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 24643104 — Surrogate Endpoint (SUR): Blood pressure
Study 18664538 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 1958451 — Surrogate Endpoint (SUR): Blood pressure
Study 31789723 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 28650680 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 25037034 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25037034 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19936182 — Surrogate Endpoint (SUR): Blood pressure
Study 14748901 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 11915781 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8761842 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8761842 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 8761842 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 8761842 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8761842 — Surrogate Endpoint (SUR): Blood pressure
Study 3838352 — Surrogate Endpoint (SUR): Blood pressure
Study 24525654 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC6A4 mRNA
Genes: SLC6A4; HTT; SERT
Study 28086813 — Surrogate Endpoint (SUR): Blood pressure
Study 15259908 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15259908 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 7875191 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21817806 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21817806 — Surrogate Endpoint (SUR): Blood pressure
Study 19702078 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19702078 — Surrogate Endpoint (SUR): Blood pressure
Study 12843002 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 10934673 — Predictive Biomarker (PRD): IL11
Genes: IL-11; AGIF
Study 21215201 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21215201 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell