TrialPanorama/TrialPanorama-database huggingface dataset:
Study 17414730 — Surrogate Endpoint (SUR): Serum creatinine
Study 17414730 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 16677798 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1327628 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 1327628 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 1327628 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1327628 — Surrogate Endpoint (SUR): Blood pressure
Study 2427842 — Surrogate Endpoint (SUR): Blood pressure
Study 27053325 — Predictive Biomarker (PRD): CYP2B6 mRNA
Genes: CYP2B6
Study 24950358 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 22892455 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 22892455 — Safety Biomarker (SAF): Interleukin 12
Study 22892455 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 22892455 — Safety Biomarker (SAF): miR-155
Genes: MIR155
Study 22892455 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-223
Genes: MIR223
Study 22892455 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-125b
Study 22892455 — Safety Biomarker (SAF): miR-146a
Genes: MIR146A
Study 21095333 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21095333 — Surrogate Endpoint (SUR): Blood pressure
Study 18678789 — Surrogate Endpoint (SUR): Blood pressure
Study 12413508 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 12413508 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 12413508 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 3119776 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 3119776 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 29428486 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 15879357 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 10475361 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 10475361 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 31987664 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24794243 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 24794243 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 24794243 — Surrogate Endpoint (SUR): Pathological complete response
Study 23036218 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 23036218 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 23036218 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 7544732 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 7544732 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7544732 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2653971 — Surrogate Endpoint (SUR): Serum calcium
Study 20234144 — Surrogate Endpoint (SUR): Serum creatinine
Study 20234144 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 28991823 — Safety Biomarker (SAF): Interleukin 1
Study 27823977 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 15485478 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15485478 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 3880997 — Surrogate Endpoint (SUR): Blood pressure
Study 31544803 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 11190420 — Predictive Biomarker (PRD): ABCC8 mRNA
Genes: ABCC8; HRINS; SUR; SUR1
Study 11190420 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 6372737 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 27997586 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27997586 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 27997586 — Surrogate Endpoint (SUR): Blood pressure
Study 22819406 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 3326679 — Surrogate Endpoint (SUR): Blood pressure
Study 11413109 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 28724657 — Surrogate Endpoint (SUR): Blood pressure
Study 23977723 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16804032 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 16804032 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10981524 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 9101380 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 9101380 — Surrogate Endpoint (SUR): Bone mineral density
Study 3298408 — Monitoring Biomarker (MOI): HBV DNA
Study 18596069 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8840339 — Surrogate Endpoint (SUR): Blood pressure
Study 21352592 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21352592 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24703723 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 24703723 — Predictive Biomarker (PRD): Hormone receptor
Study 8767241 — Surrogate Endpoint (SUR): Blood pressure
Study 6225405 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 24189504 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 20933082 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 15632662 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15632662 — Surrogate Endpoint (SUR): Blood pressure
Study 26614250 — Surrogate Endpoint (SUR): Blood pressure
Study 24204044 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12702897 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 29097438 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19679057 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 19679057 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 17356388 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17356388 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 17356388 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 15712717 — Surrogate Endpoint (SUR): Blood pressure
Study 2659383 — Surrogate Endpoint (SUR): Forced vital capacity
Study 28002684 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21127475 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9510582 — Predictive Biomarker (PRD): HBB mRNA
Genes: HBB
Study 7857751 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28676100 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 23475289 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 27115063 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19192435 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 12162507 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 12162507 — Surrogate Endpoint (SUR): Bone mineral density
Study 24714414 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24714414 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21540583 — Predictive Biomarker (PRD): CPT1A mRNA
Genes: CPT1A; CPT1
Study 21540583 — Predictive Biomarker (PRD): CPT1B mRNA
Genes: CPT1B; KIAA1670
Study 19843790 — Surrogate Endpoint (SUR): Blood pressure
Study 11449083 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11449083 — Surrogate Endpoint (SUR): Bone mineral density
Study 8030449 — Surrogate Endpoint (SUR): Serum triglycerides
Study 28989150 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 20088415 — Monitoring Biomarker (MOI): HBV DNA
Study 11689273 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 11689273 — Surrogate Endpoint (SUR): Blood pressure
Study 21953376 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 22383739 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 11419108 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23807564 — Predictive Biomarker (PRD): NR1I2
Genes: ONR1; PXR; BXR; SXR; PAR2
Study 23807564 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 23807564 — Predictive Biomarker (PRD): NR1I2 mRNA
Genes: NR1I2; PXR
Study 1092725 — Predictive Biomarker (PRD): LOX mRNA
Genes: LOX
Study 12399193 — Predictive Biomarker (PRD): MPL mRNA
Genes: MPL; TPOR
Study 12399193 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 9794569 — Surrogate Endpoint (SUR): Blood pressure
Study 9794569 — Surrogate Endpoint (SUR): Serum creatinine
Study 7655643 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 2782327 — Surrogate Endpoint (SUR): Blood pressure
Study 1090415 — Surrogate Endpoint (SUR): Blood pressure
Study 9059564 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 30056028 — Predictive Biomarker (PRD): SLC5A1 mRNA
Genes: SLC5A1; NAGT; SGLT1
Study 22872648 — Monitoring Biomarker (MOI): HBV DNA
Study 9298772 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27216303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27216303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27216303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30084962 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 29231364 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24410736 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19450157 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26301706 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 19816208 — Surrogate Endpoint (SUR): Blood pressure
Study 28083972 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 21153029 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21153029 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15172408 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 11281231 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 11281231 — Surrogate Endpoint (SUR): Blood pressure
Study 11281231 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29682590 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29682590 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27325864 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 27325864 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20053673 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 16084852 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 31607143 — Surrogate Endpoint (SUR): Blood pressure
Study 24703195 — Surrogate Endpoint (SUR): Blood pressure
Study 25191556 — Surrogate Endpoint (SUR): Blood pressure
Study 12069211 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 31819995 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24046462 — Surrogate Endpoint (SUR): Blood pressure
Study 22490626 — Surrogate Endpoint (SUR): Blood pressure
Study 2665492 — Surrogate Endpoint (SUR): Serum calcium
Study 2665492 — Surrogate Endpoint (SUR): Blood pressure
Study 19715461 — Surrogate Endpoint (SUR): Blood pressure
Study 11450767 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 11450767 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 18165968 — Predictive Biomarker (PRD): CHRNA5 mRNA
Genes: CHRNA5; NACHRA5
Study 10760103 — Surrogate Endpoint (SUR): Serum creatinine
Study 10760103 — Surrogate Endpoint (SUR): Blood pressure
Study 1445966 — Surrogate Endpoint (SUR): Blood pressure
Study 26062731 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 26062731 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 26062731 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 26062731 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21885980 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19489848 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 16769348 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7527112 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14530867 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 28154462 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 24158787 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24158787 — Predictive Biomarker (PRD): Hormone receptor
Study 20379145 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 15482516 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 29789220 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29789220 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 26710696 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 23433188 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 23433188 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 16568202 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 10539814 — Surrogate Endpoint (SUR): Blood pressure
Study 1752890 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 6282105 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 31397288 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 30221912 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25248418 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 10930147 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12771003 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 1506124 — Surrogate Endpoint (SUR): Blood pressure
Study 30179727 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19808266 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19808266 — Surrogate Endpoint (SUR): Blood pressure
Study 12174922 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 8882570 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 12069102 — Surrogate Endpoint (SUR): Serum triglycerides
Study 28757482 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 21762358 — Surrogate Endpoint (SUR): Blood pressure
Study 21762358 — Surrogate Endpoint (SUR): Serum creatinine
Study 19347979 — Predictive Biomarker (PRD): GCLC mRNA
Genes: GCLC; GLCL; GLCLC
Study 19347979 — Predictive Biomarker (PRD): GPX1 mRNA
Genes: GPX1
Study 8968180 — Surrogate Endpoint (SUR): Blood pressure
Study 25811286 — Surrogate Endpoint (SUR): Blood pressure
Study 16214026 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16214026 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16214026 — Safety Biomarker (SAF): Interleukin 1
Study 2572609 — Surrogate Endpoint (SUR): Blood pressure
Study 25940675 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 25940675 — Pharmacodynamic Biomarker (PDY): Antidrug antibody
Study 25940675 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25940675 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23836190 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23836190 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 19692495 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 12066721 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 7867683 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2092 — Surrogate Endpoint (SUR): Blood pressure
Study 9866361 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 7649579 — Surrogate Endpoint (SUR): Blood pressure
Study 30701387 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 30701387 — Predictive Biomarker (PRD): SQSTM1 mRNA
Genes: SQSTM1; ORCA; OSIL
Study 30701387 — Safety Biomarker (SAF): Reactive oxygen species
Study 25368978 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 25368978 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 24673467 — Surrogate Endpoint (SUR): Probing pocket depth
Study 8598936 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 28150855 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 28150855 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 2858215 — Surrogate Endpoint (SUR): Blood pressure
Study 14648210 — Predictive Biomarker (PRD): CPA1 mRNA
Genes: CPA1; CPA
Study 29484149 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 29484149 — Predictive Biomarker (PRD): ASL mRNA
Genes: ASL
Study 29484149 — Predictive Biomarker (PRD): AZIN2 mRNA
Genes: AZIN2; ADC; KIAA1945; ODCP
Study 22998978 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 22998978 — Predictive Biomarker (PRD): NPC1L1 mRNA
Genes: NPC1L1
Study 18624109 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 10954008 — Surrogate Endpoint (SUR): Serum uric acid
Study 9411420 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31810744 — Surrogate Endpoint (SUR): Blood pressure
Study 25595117 — Predictive Biomarker (PRD): NLRP1 mRNA
Genes: NLRP1; CARD7; DEFCAP; KIAA0926; NAC; NALP1
Study 14738417 — Predictive Biomarker (PRD): SULT1A3 mRNA
Genes: SULT1A3; STM
Study 29338111 — Surrogate Endpoint (SUR): Blood pressure
Study 26584856 — Surrogate Endpoint (SUR): Blood pressure
Study 28470676 — Predictive Biomarker (PRD): ACACB mRNA
Genes: ACACB; ACC2; ACCB
Study 17893531 — Predictive Biomarker (PRD): AMT mRNA
Genes: AMT; GCST
Study 2048574 — Surrogate Endpoint (SUR): Blood pressure
Study 16389668 — Predictive Biomarker (PRD): UBR5 mRNA
Genes: UBR5; EDD; EDD1; HYD; KIAA0896
Study 1889973 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 12757116 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 6382127 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 8707476 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 31494945 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 29599611 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 26913649 — Safety Biomarker (SAF): Vascular endothelial cadherin
Genes: CDH5
Study 15559483 — Surrogate Endpoint (SUR): Blood pressure
Study 11516109 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 11516109 — Predictive Biomarker (PRD): TOX mRNA
Genes: TOX; KIAA0808
Study 11516109 — Predictive Biomarker (PRD): REL mRNA
Genes: REL
Study 8388949 — Safety Biomarker (SAF): Interleukin 1
Study 6370703 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 6370703 — Surrogate Endpoint (SUR): Blood pressure
Study 29849487 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24272364 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 19282749 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23945386 — Predictive Biomarker (PRD): WT1 mRNA
Genes: WT1
Study 23945386 — Predictive Biomarker (PRD): Epithelial cadherin
Genes: CDH1; CDHE; UVO
Study 12932090 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 394870 — Predictive Biomarker (PRD): MERTK mRNA
Genes: MERTK; MER
Study 15126758 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 9470910 — Predictive Biomarker (PRD): GLS2 mRNA
Genes: GLS2; GA
Study 31728714 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 21808761 — Surrogate Endpoint (SUR): Probing pocket depth
Study 2772103 — Surrogate Endpoint (SUR): Blood pressure
Study 25196702 — Predictive Biomarker (PRD): SRC mRNA
Genes: SRC; SRC1
Study 25196702 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 25196702 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 23623755 — Surrogate Endpoint (SUR): Blood pressure
Study 3090723 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 29703633 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 29703633 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 29703633 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 29703633 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2