TrialPanorama/TrialPanorama-database huggingface dataset:
Study 9828635 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 30851066 — Surrogate Endpoint (SUR): Blood pressure
Study 16963035 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 1518122 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 27278933 — Surrogate Endpoint (SUR): Blood pressure
Study 26637482 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 16540840 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16540840 — Surrogate Endpoint (SUR): Blood pressure
Study 12959740 — Surrogate Endpoint (SUR): Serum calcium
Study 12959740 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 30304141 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22309404 — Surrogate Endpoint (SUR): Blood pressure
Study 26178495 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26178495 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 26178495 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17581594 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 9445498 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 31132978 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31132978 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19057451 — Surrogate Endpoint (SUR): Blood pressure
Study 11597377 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 9816659 — Predictive Biomarker (PRD): PTGDS mRNA
Genes: PTGDS; PDS
Study 26080850 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 23010883 — Surrogate Endpoint (SUR): Bone mineral density
Study 12529661 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 30585388 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 18390968 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 18390968 — Predictive Biomarker (PRD): NRAS mRNA
Genes: NRAS; HRAS1
Study 18390968 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 24996807 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17692153 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 17692153 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26647373 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 24961493 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24961493 — Surrogate Endpoint (SUR): Blood pressure
Study 2617243 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 28159196 — Surrogate Endpoint (SUR): Blood pressure
Study 23076431 — Surrogate Endpoint (SUR): Blood pressure
Study 15799170 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15799170 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15799170 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23583566 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 23577078 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 18547996 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18547996 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31331699 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31331699 — Predictive Biomarker (PRD): PDGFRB mRNA
Genes: PDGFRB; PDGFR; PDGFR1
Study 31331699 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 18654123 — Surrogate Endpoint (SUR): Blood pressure
Study 11310690 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31206225 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31206225 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23791894 — Predictive Biomarker (PRD): TRPV1 mRNA
Genes: TRPV1; VR1
Study 14528504 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22859346 — Safety Biomarker (SAF): Interleukin 1
Study 8885114 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 27056776 — Predictive Biomarker (PRD): SRI mRNA
Genes: SRI
Study 17908710 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 8317392 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23090161 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12200985 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 30918967 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26087472 — Predictive Biomarker (PRD): SPARC mRNA
Genes: SPARC; ON
Study 24740208 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 21149672 — Predictive Biomarker (PRD): ERCC8 mRNA
Genes: ERCC8; CKN1; CSA
Study 21149672 — Surrogate Endpoint (SUR): Hematologic response
Study 6122752 — Surrogate Endpoint (SUR): Blood pressure
Study 28699032 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 21044933 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12894958 — Surrogate Endpoint (SUR): Blood pressure
Study 8507812 — Surrogate Endpoint (SUR): Blood pressure
Study 31218477 — Predictive Biomarker (PRD): Hormone receptor
Study 20856123 — Predictive Biomarker (PRD): MT2A mRNA
Genes: MT2A; CES1; MT2
Study 30025397 — Predictive Biomarker (PRD): TNFSF13B mRNA
Genes: TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; UNQ401/PRO738
Study 30025397 — Predictive Biomarker (PRD): CD24 mRNA
Genes: CD24; CD24A
Study 30025397 — Predictive Biomarker (PRD): CD27 mRNA
Genes: CD27; TNFRSF7
Study 30025397 — Monitoring Biomarker (MOI): HBV DNA
Study 27720506 — Surrogate Endpoint (SUR): Blood pressure
Study 25082565 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 15586364 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 29573665 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 29573665 — Predictive Biomarker (PRD): Hormone receptor
Study 24639042 — Surrogate Endpoint (SUR): Blood pressure
Study 19383060 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 15159491 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 9828914 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31901246 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31901246 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23382484 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 23382484 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 11006178 — Surrogate Endpoint (SUR): Bone mineral density
Study 31630870 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31630870 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30378591 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 24430407 — Safety Biomarker (SAF): Hyaluronic acid
Study 16105425 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10597336 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17968979 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 28026901 — Surrogate Endpoint (SUR): Bone mineral density
Study 23433446 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 22340792 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 22340792 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 16757701 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 11255519 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31346621 — Safety Biomarker (SAF): Hyaluronic acid
Study 21692613 — Safety Biomarker (SAF): Thiopurine S-methyltransferase
Genes: TPMT
Study 1877599 — Surrogate Endpoint (SUR): Blood pressure
Study 23652897 — Safety Biomarker (SAF): Hyaluronic acid
Study 23093401 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 23093401 — Surrogate Endpoint (SUR): Blood pressure
Study 20145447 — Surrogate Endpoint (SUR): Blood pressure
Study 18634163 — Safety Biomarker (SAF): Interleukin 1
Study 12816624 — Surrogate Endpoint (SUR): Blood pressure
Study 26371518 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26371518 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26371518 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21443446 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 21443446 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 11495672 — Surrogate Endpoint (SUR): Blood pressure
Study 9754980 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 30793466 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30793466 — Surrogate Endpoint (SUR): Serum creatinine
Study 30793466 — Surrogate Endpoint (SUR): Blood pressure
Study 20378005 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 20378005 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 23168014 — Predictive Biomarker (PRD): EDNRA mRNA
Genes: EDNRA; ETA; ETRA
Study 23168014 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 23168014 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 23168014 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 23168014 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17217741 — Surrogate Endpoint (SUR): Blood pressure
Study 17217741 — Surrogate Endpoint (SUR): Serum creatinine
Study 1513113 — Surrogate Endpoint (SUR): Blood pressure
Study 31444162 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 28125093 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 24591332 — Surrogate Endpoint (SUR): Blood pressure
Study 16800833 — Surrogate Endpoint (SUR): Blood pressure
Study 3889027 — Surrogate Endpoint (SUR): Blood pressure
Study 3889027 — Surrogate Endpoint (SUR): Serum uric acid
Study 22417870 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 22417870 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 14551174 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 14551174 — Surrogate Endpoint (SUR): Blood pressure
Study 10958766 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 8793612 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8793612 — Surrogate Endpoint (SUR): Blood pressure
Study 27189028 — Surrogate Endpoint (SUR): Blood pressure
Study 23742222 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23742222 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20211036 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 10522983 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 23175270 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 16552403 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 16552403 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 16552403 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 14636839 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 3917315 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 25237670 — Surrogate Endpoint (SUR): Probing pocket depth
Study 23348814 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 20492047 — Surrogate Endpoint (SUR): Blood pressure
Study 9625541 — Surrogate Endpoint (SUR): Blood pressure
Study 30968604 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 25387260 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 7962336 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 7962336 — Predictive Biomarker (PRD): TPO mRNA
Genes: TPO
Study 10365642 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 1645768 — Surrogate Endpoint (SUR): Blood pressure
Study 28853202 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 28853202 — Predictive Biomarker (PRD): HSPA5 mRNA
Genes: HSPA5; GRP78
Study 28853202 — Predictive Biomarker (PRD): BAK1 mRNA
Genes: BAK1; BAK; BCL2L7; CDN1
Study 28853202 — Predictive Biomarker (PRD): BAX mRNA
Genes: BAX; BCL2L4
Study 28853202 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-34a
Genes: MIR34A
Study 19841330 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 11894174 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 646248 — Surrogate Endpoint (SUR): Blood pressure
Study 11294130 — Surrogate Endpoint (SUR): Blood pressure
Study 24555913 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 24555913 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22241059 — Surrogate Endpoint (SUR): Forced vital capacity
Study 22241059 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 9656196 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 24560287 — Predictive Biomarker (PRD): AIFM1 mRNA
Genes: AIFM1; AIF; PDCD8
Study 19349586 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 17189867 — Surrogate Endpoint (SUR): Blood pressure
Study 19125899 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19125899 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19125899 — Surrogate Endpoint (SUR): Blood pressure
Study 29505517 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16373244 — Surrogate Endpoint (SUR): Blood pressure
Study 16373244 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1978612 — Surrogate Endpoint (SUR): Blood pressure
Study 64653 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 23719582 — Predictive Biomarker (PRD): Carbonic anhydrase IX
Genes: CA9; G250; MN
Study 19273696 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 23193016 — Predictive Biomarker (PRD): DLX5 mRNA
Genes: DLX5
Study 23193016 — Predictive Biomarker (PRD): IGF2-AS
Study 23193016 — Predictive Biomarker (PRD): TP73 mRNA
Genes: TP73; P73
Study 22352262 — Safety Biomarker (SAF): Hyaluronic acid
Study 26363312 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 1 beta
Genes: IL1B; IL1F2
Study 21915572 — Surrogate Endpoint (SUR): Bone mineral density
Study 14687899 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31141104 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 27126239 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 16135173 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 30971277 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8177478 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 8177478 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 30677319 — Predictive Biomarker (PRD): AFM mRNA
Genes: AFM; ALB2; ALBA
Study 2856769 — Surrogate Endpoint (SUR): Blood pressure
Study 29251010 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 29251010 — Surrogate Endpoint (SUR): Bone mineral density
Study 26351087 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23910392 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 16412037 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 24072699 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16809937 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 9208533 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9208533 — Predictive Biomarker (PRD): STIL mRNA
Genes: STIL; SIL
Study 19995098 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19995098 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27723261 — Safety Biomarker (SAF): Hyaluronic acid
Study 23504220 — Surrogate Endpoint (SUR): Blood pressure
Study 8041534 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2537333 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 2537333 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 1125586 — Surrogate Endpoint (SUR): Blood pressure
Study 30641096 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 30641096 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 23062021 — Surrogate Endpoint (SUR): Blood pressure
Study 18653546 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 18653546 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29957279 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15780536 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 10521549 — Safety Biomarker (SAF): Hyaluronic acid
Study 21845038 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 21845038 — Surrogate Endpoint (SUR): Forced vital capacity
Study 7649593 — Surrogate Endpoint (SUR): Blood pressure
Study 19852293 — Predictive Biomarker (PRD): KITLG mRNA
Genes: KITLG; MGF; SCF
Study 15730812 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 15730812 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 9928566 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 7851270 — Surrogate Endpoint (SUR): Forced vital capacity
Study 16554313 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 16114784 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16114784 — Surrogate Endpoint (SUR): Blood pressure
Study 10517426 — Surrogate Endpoint (SUR): Hemagglutination inhibition antibody
Study 25043337 — Safety Biomarker (SAF): DRD2
Study 15010183 — Surrogate Endpoint (SUR): Blood pressure
Study 7835358 — Surrogate Endpoint (SUR): Blood pressure
Study 16818033 — Pharmacodynamic Biomarker (PDY): Gamma-Histone H2AX
Genes: H2AX; H2AFX
Study 26903486 — Surrogate Endpoint (SUR): Forced vital capacity
Study 15757851 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15757851 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 15757851 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15757851 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24720928 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 12694346 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1992306 — Surrogate Endpoint (SUR): Serum calcium
Study 6362210 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 17323183 — Surrogate Endpoint (SUR): Bone mineral density
Study 1631861 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 6708394 — Surrogate Endpoint (SUR): Blood pressure
Study 31382822 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31382822 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15232503 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 15232503 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 29044968 — Predictive Biomarker (PRD): DUT mRNA
Genes: DUT
Study 24520784 — Safety Biomarker (SAF): Interleukin 1
Study 24520784 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24520784 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24520784 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 18029492 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 30264170 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 30264170 — Safety Biomarker (SAF): MTHFR
Study 22288893 — Pharmacodynamic Biomarker (PDY): Fatty acid amide hydrolase 1
Genes: FAAH; FAAH1
Study 22288893 — Predictive Biomarker (PRD): CNR1 mRNA
Genes: CNR1; CNR
Study 17394959 — Surrogate Endpoint (SUR): Serum creatinine
Study 8795770 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9736552 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7802178 — Surrogate Endpoint (SUR): Blood pressure
Study 10681809 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 7244391 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 26274346 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 22546623 — Surrogate Endpoint (SUR): Blood pressure
Study 28035541 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10329884 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34