TrialPanorama/TrialPanorama-database huggingface dataset:
Study 10598599 — Surrogate Endpoint (SUR): Blood pressure
Study 26219195 — Predictive Biomarker (PRD): CCL28 mRNA
Genes: CCL28; SCYA28
Study 19179968 — Monitoring Biomarker (MOI): HBV DNA
Study 15257187 — Surrogate Endpoint (SUR): Blood pressure
Study 8287747 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23316290 — Safety Biomarker (SAF): DRD2
Study 23316290 — Surrogate Endpoint (SUR): Blood pressure
Study 8911887 — Surrogate Endpoint (SUR): Blood pressure
Study 20056480 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17236758 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 14747278 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 3526655 — Surrogate Endpoint (SUR): Serum creatinine
Study 31895032 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 29509522 — Surrogate Endpoint (SUR): Blood pressure
Study 12895218 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 26446770 — Surrogate Endpoint (SUR): Bone mineral density
Study 24395109 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 24395109 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 18258621 — Surrogate Endpoint (SUR): Blood pressure
Study 16504369 — Surrogate Endpoint (SUR): Blood pressure
Study 8639310 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 24485216 — Surrogate Endpoint (SUR): Bone mineral density
Study 21115766 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 16386181 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16386181 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 2288512 — Surrogate Endpoint (SUR): Blood pressure
Study 6792916 — Surrogate Endpoint (SUR): Blood pressure
Study 25432103 — Surrogate Endpoint (SUR): Serum creatinine
Study 3038428 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3038428 — Surrogate Endpoint (SUR): Blood pressure
Study 3038428 — Surrogate Endpoint (SUR): Serum potassium
Study 17121050 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 10678139 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1682905 — Surrogate Endpoint (SUR): Blood pressure
Study 26355164 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23447453 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23447453 — Surrogate Endpoint (SUR): Blood pressure
Study 16482075 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 2172371 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2172371 — Surrogate Endpoint (SUR): Blood pressure
Study 23648055 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 21936344 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18421047 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 8551753 — Surrogate Endpoint (SUR): Platelet count response
Study 8551753 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 8551753 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 8551753 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 9380806 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9380806 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25177814 — Surrogate Endpoint (SUR): Blood pressure
Study 25177814 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25177814 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7400476 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 25568560 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 25568560 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25568560 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17324679 — Surrogate Endpoint (SUR): Blood pressure
Study 24356394 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 3775328 — Surrogate Endpoint (SUR): Blood pressure
Study 24238032 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22023655 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 20007307 — Surrogate Endpoint (SUR): Blood pressure
Study 20007307 — Surrogate Endpoint (SUR): Serum sodium
Study 18797348 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 18797348 — Safety Biomarker (SAF): BDNF
Study 22913215 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17878469 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 12148095 — Surrogate Endpoint (SUR): Serum creatinine
Study 12162939 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 27893864 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24606088 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 12066723 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 10522560 — Surrogate Endpoint (SUR): Serum uric acid
Study 10522560 — Surrogate Endpoint (SUR): Blood pressure
Study 1791605 — Surrogate Endpoint (SUR): Blood pressure
Study 25637937 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21843836 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17604664 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 8808724 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 18666803 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18666803 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 18666803 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 18666803 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18666803 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16613662 — Surrogate Endpoint (SUR): Serum calcium
Study 29998882 — Monitoring Biomarker (MOI): HBV DNA
Study 16095062 — Surrogate Endpoint (SUR): Blood pressure
Study 9748859 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28733983 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 2892252 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 23221739 — Surrogate Endpoint (SUR): Serum calcium
Study 20956208 — Surrogate Endpoint (SUR): Blood pressure
Study 8245373 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25127924 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25127924 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 25127924 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 25127924 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25127924 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25127924 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 25127924 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 10792337 — Surrogate Endpoint (SUR): Bone mineral density
Study 30595443 — Surrogate Endpoint (SUR): Blood pressure
Study 29753099 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 12599085 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 9361930 — Surrogate Endpoint (SUR): Serum creatinine
Study 3887850 — Surrogate Endpoint (SUR): Blood pressure
Study 24886552 — Surrogate Endpoint (SUR): Blood pressure
Study 12805333 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 6359877 — Surrogate Endpoint (SUR): Serum creatinine
Study 31578781 — Surrogate Endpoint (SUR): Blood pressure
Study 20860912 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 22739328 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11494096 — Surrogate Endpoint (SUR): Blood pressure
Study 9255751 — Surrogate Endpoint (SUR): Blood pressure
Study 8509588 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8509588 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10375241 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 24413262 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27781307 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 25700288 — Surrogate Endpoint (SUR): Blood pressure
Study 23053684 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 15465627 — Pharmacodynamic Biomarker (PDY): Amyloid beta peptide (1-40)
Genes: APP; A4; AD1
Study 15465627 — Predictive Biomarker (PRD): LIPA mRNA
Genes: LIPA
Study 15465627 — Predictive Biomarker (PRD): CH25H mRNA
Genes: CH25H
Study 9879196 — Surrogate Endpoint (SUR): Blood pressure
Study 21978016 — Predictive Biomarker (PRD): PRF1
Genes: PFP; P1; HPLH2
Study 17225620 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 9466128 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9466128 — Safety Biomarker (SAF): Interleukin 1
Study 9466128 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26486857 — Surrogate Endpoint (SUR): Blood pressure
Study 12571611 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 12571611 — Surrogate Endpoint (SUR): Blood pressure
Study 4009829 — Surrogate Endpoint (SUR): Serum sodium
Study 29566463 — Surrogate Endpoint (SUR): Blood pressure
Study 19937362 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10587025 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 8905434 — Surrogate Endpoint (SUR): Blood pressure
Study 1860008 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1860008 — Surrogate Endpoint (SUR): Blood pressure
Study 28119329 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 25828362 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CXCL1 mRNA
Genes: CXCL1; GRO; GRO1; GROA; MGSA; SCYB1
Study 25828362 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 23560618 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 15050487 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15050487 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24011093 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11257278 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 8852539 — Surrogate Endpoint (SUR): Blood pressure
Study 26442364 — Surrogate Endpoint (SUR): Blood pressure
Study 23497163 — Surrogate Endpoint (SUR): Blood pressure
Study 18468748 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18468748 — Surrogate Endpoint (SUR): Blood pressure
Study 18468748 — Surrogate Endpoint (SUR): Serum potassium
Study 17000967 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12853381 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 12853381 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 10928765 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19040374 — Surrogate Endpoint (SUR): Blood pressure
Study 26282839 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 19597720 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 2692810 — Surrogate Endpoint (SUR): Blood pressure
Study 11304774 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 27323446 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 27323446 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 27323446 — Surrogate Endpoint (SUR): Forced vital capacity
Study 9162315 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 3925656 — Surrogate Endpoint (SUR): Blood pressure
Study 20332351 — Surrogate Endpoint (SUR): Blood pressure
Study 15716701 — Safety Biomarker (SAF): Reactive oxygen species
Study 15716701 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15716701 — Surrogate Endpoint (SUR): Blood pressure
Study 8523379 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8523379 — Surrogate Endpoint (SUR): Blood pressure
Study 17854661 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 15078748 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 3141856 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 20506261 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 2853731 — Surrogate Endpoint (SUR): Blood pressure
Study 24524605 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 28265014 — Predictive Biomarker (PRD): HSPB1 mRNA
Genes: HSPB1; HSP27; HSP28
Study 28265014 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 11344347 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 7910229 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27430332 — Surrogate Endpoint (SUR): Blood pressure
Study 16961684 — Surrogate Endpoint (SUR): Plasma phenylalanine
Study 11083258 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9157579 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 21916526 — Predictive Biomarker (PRD): GSTM1 mRNA
Genes: GSTM1; GST1
Study 20539277 — Predictive Biomarker (PRD): GNB3 mRNA
Genes: GNB3
Study 18294268 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 16047459 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 8536776 — Surrogate Endpoint (SUR): Blood pressure
Study 1775604 — Surrogate Endpoint (SUR): Blood pressure
Study 9030833 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 9030833 — Surrogate Endpoint (SUR): Bone mineral density
Study 28162769 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25884885 — Surrogate Endpoint (SUR): Blood pressure
Study 9880129 — Surrogate Endpoint (SUR): Blood pressure
Study 23499145 — Surrogate Endpoint (SUR): Blood pressure
Study 11762415 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 2564563 — Predictive Biomarker (PRD): ARC mRNA
Genes: ARC; KIAA0278
Study 7631298 — Surrogate Endpoint (SUR): Blood pressure
Study 1849536 — Surrogate Endpoint (SUR): Blood pressure
Study 28736511 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 28408635 — Predictive Biomarker (PRD): SLC25A20 mRNA
Genes: SLC25A20; CAC; CACT
Study 26975625 — Predictive Biomarker (PRD): DMTN mRNA
Genes: DMTN; DMT; EPB49
Study 20175431 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 17471993 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17471993 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 17471993 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 15955104 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28545998 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 28545998 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 19781835 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19781835 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11781670 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31921171 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 31921171 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 26797725 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22566588 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20439216 — Surrogate Endpoint (SUR): Bone mineral density
Study 1708037 — Surrogate Endpoint (SUR): Blood pressure
Study 29734777 — Surrogate Endpoint (SUR): Blood pressure
Study 24941177 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24941177 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21805328 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 8390340 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8390340 — Surrogate Endpoint (SUR): Bone mineral density
Study 31072380 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 25243962 — Safety Biomarker (SAF): Hyaluronic acid
Study 25243962 — Monitoring Biomarker (MOI): HBV DNA
Study 22007735 — Surrogate Endpoint (SUR): Blood pressure
Study 20448634 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 20448634 — Surrogate Endpoint (SUR): Blood pressure
Study 20448634 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 7743571 — Surrogate Endpoint (SUR): Blood pressure
Study 1559299 — Surrogate Endpoint (SUR): Serum sodium
Study 3876763 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23361591 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23361591 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19845233 — Safety Biomarker (SAF): Reactive oxygen species
Study 19845233 — Surrogate Endpoint (SUR): Serum creatinine
Study 11340314 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 9404414 — Surrogate Endpoint (SUR): Blood pressure
Study 8200011 — Surrogate Endpoint (SUR): Serum triglycerides
Study 22730912 — Safety Biomarker (SAF): Reactive oxygen species
Study 30787666 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 8031733 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8031733 — Surrogate Endpoint (SUR): Blood pressure
Study 25619410 — Surrogate Endpoint (SUR): Blood pressure
Study 23789212 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23789212 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23789212 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23789212 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23789212 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6343164 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 17294225 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 17294225 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17294225 — Surrogate Endpoint (SUR): Bone mineral density
Study 7911057 — Surrogate Endpoint (SUR): Blood pressure
Study 2843201 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2843201 — Surrogate Endpoint (SUR): Blood pressure
Study 21227010 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 21227010 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26572788 — Surrogate Endpoint (SUR): Blood pressure
Study 19843672 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12623938 — Predictive Biomarker (PRD): MTOR mRNA
Genes: MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Study 12623938 — Surrogate Endpoint (SUR): Blood pressure
Study 9115051 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 9115051 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 15339769 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 25803666 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15189292 — Predictive Biomarker (PRD): RHD mRNA
Genes: RHD
Study 25505013 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 24588965 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): miR-124
Study 20455988 — Surrogate Endpoint (SUR): Blood pressure
Study 28338223 — Safety Biomarker (SAF): Interleukin 12
Study 19939653 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19939653 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19939653 — Surrogate Endpoint (SUR): Blood pressure
Study 10910028 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9341968 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 3022512 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3022512 — Surrogate Endpoint (SUR): Blood pressure
Study 3938935 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 16956824 — Predictive Biomarker (PRD): Liver iron
Study 15329007 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 15329007 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 20387250 — Predictive Biomarker (PRD): TG mRNA
Genes: TG