TrialPanorama/TrialPanorama-database huggingface dataset:
Study 8972009 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 24877590 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24877590 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 24877590 — Surrogate Endpoint (SUR): Serum uric acid
Study 11780380 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 17605895 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17605895 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 7541210 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 7541210 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30192390 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 20490798 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 20490798 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 20490798 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 14646349 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 14646349 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 14646349 — Predictive Biomarker (PRD): STAT5A mRNA
Genes: STAT5A; STAT5
Study 14646349 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 14646349 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 14646349 — Predictive Biomarker (PRD): FLT3 mRNA
Genes: FLT3; CD135; FLK2; STK1
Study 2809562 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 2809562 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 22385133 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 20664016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20664016 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20664016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20664016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12439805 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10353554 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10353554 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19208305 — Surrogate Endpoint (SUR): Blood pressure
Study 16534680 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 12492458 — Safety Biomarker (SAF): Interleukin 12
Study 12492458 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 12462824 — Surrogate Endpoint (SUR): Blood pressure
Study 8856491 — Surrogate Endpoint (SUR): Blood pressure
Study 23418046 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23418046 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23418046 — Safety Biomarker (SAF): Hyaluronic acid
Study 21335930 — Predictive Biomarker (PRD): GAL3ST1 mRNA
Genes: GAL3ST1; CST
Study 11721319 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11721319 — Surrogate Endpoint (SUR): Blood pressure
Study 3033593 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 12942586 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8846275 — Surrogate Endpoint (SUR): Blood pressure
Study 29211305 — Surrogate Endpoint (SUR): Bone mineral density
Study 25281438 — Surrogate Endpoint (SUR): Blood pressure
Study 18157288 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 10208507 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10208507 — Safety Biomarker (SAF): Interleukin 1
Study 10208507 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 10208507 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 10208507 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 10208507 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17869497 — Surrogate Endpoint (SUR): Blood pressure
Study 16849999 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 16849999 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 24125402 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 24125402 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24947459 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 14513417 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28232097 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 28232097 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 23966331 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 18157013 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10930199 — Surrogate Endpoint (SUR): Blood pressure
Study 22068809 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2883920 — Predictive Biomarker (PRD): BLVRA mRNA
Genes: BLVRA; BLVR; BVR
Study 8690806 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 8690806 — Predictive Biomarker (PRD): PDXP mRNA
Genes: PDXP; CIN; PLP; PLPP
Study 8690806 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 23857741 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23857741 — Surrogate Endpoint (SUR): Bone mineral density
Study 16510370 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1897688 — Surrogate Endpoint (SUR): Forced vital capacity
Study 20390477 — Predictive Biomarker (PRD): NRP1 mRNA
Genes: NRP1; NRP; VEGF165R
Study 17440005 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 23278132 — Predictive Biomarker (PRD): EDAR mRNA
Genes: EDAR; DL
Study 19100416 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 1618253 — Surrogate Endpoint (SUR): Serum potassium
Study 9558432 — Surrogate Endpoint (SUR): Blood pressure
Study 28673814 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 28673814 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21346689 — Surrogate Endpoint (SUR): Blood pressure
Study 12079900 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28488685 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11554015 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 11554015 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 11554015 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 8148280 — Surrogate Endpoint (SUR): Serum creatinine
Study 23748750 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 19099634 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24687830 — Safety Biomarker (SAF): HLA-DRB1
Genes: HLA-DR1B
Study 24687830 — Safety Biomarker (SAF): HLA-DQA1
Genes: CELIAC1
Study 20399512 — Predictive Biomarker (PRD): IFNGR1 mRNA
Genes: IFNGR1
Study 20399512 — Predictive Biomarker (PRD): CD209 mRNA
Genes: CD209; CLEC4L
Study 20399512 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 1 beta
Genes: IL1B; IL1F2
Study 20399512 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 20399512 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 20399512 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 12 beta
Genes: IL12B; NKSF2
Study 20399512 — Predictive Biomarker (PRD): IL12RB1 mRNA
Genes: IL12RB1; IL12R; IL12RB
Study 20399512 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 20399512 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 7949271 — Surrogate Endpoint (SUR): Blood pressure
Study 2853751 — Surrogate Endpoint (SUR): Blood pressure
Study 31339533 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 15930210 — Surrogate Endpoint (SUR): Blood pressure
Study 29901815 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29901815 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29901815 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22046977 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30976888 — Surrogate Endpoint (SUR): Bone mineral density
Study 3904378 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3904378 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27498268 — Surrogate Endpoint (SUR): Blood pressure
Study 20835904 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20835904 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 23275364 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 23275364 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 26756540 — Predictive Biomarker (PRD): MCAT mRNA
Genes: MCAT; MT
Study 18331218 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 11487258 — Surrogate Endpoint (SUR): Bone mineral density
Study 30157896 — Predictive Biomarker (PRD): MMD mRNA
Genes: MMD; PAQR11
Study 22785264 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 15942292 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 15942292 — Pharmacodynamic Biomarker (PDY): T-lymphocyte activation antigen CD86
Genes: CD86; CD28LG2
Study 27000391 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 21121983 — Predictive Biomarker (PRD): GSS mRNA
Genes: GSS
Study 18950932 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 18950932 — Pharmacodynamic Biomarker (PDY): T-lymphocyte activation antigen CD86
Genes: CD86; CD28LG2
Study 18950932 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 17335331 — Predictive Biomarker (PRD): CGAS mRNA
Genes: CGAS; C6orf150; MB21D1
Study 21600518 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 21600518 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21600518 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17908726 — Surrogate Endpoint (SUR): Blood pressure
Study 31712768 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25488124 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25488124 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 22730366 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16501017 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CHRM2 mRNA
Genes: CHRM2
Study 15489091 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2786751 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 23429258 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 23429258 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 14575730 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 9727892 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 22615342 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20231684 — Predictive Biomarker (PRD): HSPB1 mRNA
Genes: HSPB1; HSP27; HSP28
Study 15959668 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 2681593 — Surrogate Endpoint (SUR): Blood pressure
Study 12661806 — Surrogate Endpoint (SUR): Serum potassium
Study 9366582 — Surrogate Endpoint (SUR): Serum calcium
Study 2439780 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2439780 — Surrogate Endpoint (SUR): Blood pressure
Study 27431654 — Predictive Biomarker (PRD): ADIPOQ mRNA
Genes: ADIPOQ; ACDC; ACRP30; APM1; GBP28
Study 24855350 — Surrogate Endpoint (SUR): Forced vital capacity
Study 21761341 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 15547086 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 11182190 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 10549446 — Surrogate Endpoint (SUR): Blood pressure
Study 2679978 — Surrogate Endpoint (SUR): Blood pressure
Study 1252881 — Surrogate Endpoint (SUR): Blood pressure
Study 8632537 — Surrogate Endpoint (SUR): Pathological complete response
Study 25155608 — Predictive Biomarker (PRD): CEBPA mRNA
Genes: CEBPA; CEBP
Study 25155608 — Predictive Biomarker (PRD): ADIPOQ mRNA
Genes: ADIPOQ; ACDC; ACRP30; APM1; GBP28
Study 25155608 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 25155608 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 22289222 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 25591433 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 25591433 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 25591433 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 17339748 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 11678486 — Surrogate Endpoint (SUR): Blood pressure
Study 27458809 — Surrogate Endpoint (SUR): Blood pressure
Study 20838060 — Surrogate Endpoint (SUR): Serum creatinine
Study 9403034 — Predictive Biomarker (PRD): GSTM1 mRNA
Genes: GSTM1; GST1
Study 24252583 — Surrogate Endpoint (SUR): Blood pressure
Study 20595155 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 20595155 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 18327093 — Surrogate Endpoint (SUR): Blood pressure
Study 18327093 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6754210 — Surrogate Endpoint (SUR): Blood pressure
Study 28585932 — Predictive Biomarker (PRD): REST mRNA
Genes: REST; NRSF; XBR
Study 25266695 — Predictive Biomarker (PRD): PAG1 mRNA
Genes: PAG1; CBP; PAG
Study 21190079 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 17068892 — Surrogate Endpoint (SUR): Serum creatinine
Study 12607650 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 10665127 — Surrogate Endpoint (SUR): Blood pressure
Study 1649575 — Surrogate Endpoint (SUR): Serum creatinine
Study 23241003 — Surrogate Endpoint (SUR): Blood pressure
Study 19843671 — Predictive Biomarker (PRD): MTR mRNA
Genes: MTR
Study 19843671 — Predictive Biomarker (PRD): MTRR mRNA
Genes: MTRR
Study 19843671 — Predictive Biomarker (PRD): EHMT2 mRNA
Genes: EHMT2; BAT8; C6orf30; G9A; KMT1C; NG36
Study 19843671 — Predictive Biomarker (PRD): PRDM2 mRNA
Genes: PRDM2; KMT8; RIZ
Study 19843671 — Predictive Biomarker (PRD): MLH1 mRNA
Genes: MLH1; COCA2
Study 19843671 — Predictive Biomarker (PRD): Microsatellite instability
Study 11534420 — Predictive Biomarker (PRD): RB1
Genes: RB; PPP1R130
Study 26016859 — Surrogate Endpoint (SUR): Serum triglycerides
Study 26016859 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22456691 — Surrogate Endpoint (SUR): Blood pressure
Study 22456691 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16928979 — Surrogate Endpoint (SUR): Bone mineral density
Study 31067131 — Surrogate Endpoint (SUR): Blood pressure
Study 27564409 — Surrogate Endpoint (SUR): Serum creatinine
Study 25829346 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 16652380 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 1691403 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1691403 — Surrogate Endpoint (SUR): Blood pressure
Study 28453740 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 26319423 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 1511045 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 24709495 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24709495 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 24709495 — Surrogate Endpoint (SUR): Blood pressure
Study 15449975 — Surrogate Endpoint (SUR): Blood pressure
Study 28501343 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28501343 — Surrogate Endpoint (SUR): Blood pressure
Study 23582589 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 23582589 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20081225 — Surrogate Endpoint (SUR): Blood pressure
Study 7484516 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 7484516 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 1851683 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 7177292 — Surrogate Endpoint (SUR): Serum calcium
Study 27286961 — Safety Biomarker (SAF): Hyaluronic acid
Study 24984823 — Surrogate Endpoint (SUR): Blood pressure
Study 18561516 — Surrogate Endpoint (SUR): Blood pressure
Study 30246883 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 30246883 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 30246883 — Safety Biomarker (SAF): Interleukin 1
Study 6985560 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 6985560 — Surrogate Endpoint (SUR): Blood pressure
Study 24326780 — Predictive Biomarker (PRD): AMT mRNA
Genes: AMT; GCST
Study 24030946 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21173180 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 21173180 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 27707440 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27707440 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26277173 — Surrogate Endpoint (SUR): Bone mineral density
Study 11590492 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26632428 — Surrogate Endpoint (SUR): Blood pressure
Study 1539851 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 7918310 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 14519051 — Surrogate Endpoint (SUR): Blood pressure
Study 22430266 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 22430266 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 12480610 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 13679496 — Surrogate Endpoint (SUR): Blood pressure
Study 3880775 — Surrogate Endpoint (SUR): Plasma phenylalanine
Study 28145050 — Predictive Biomarker (PRD): CYP2B6 mRNA
Genes: CYP2B6
Study 28145050 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 28145050 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 12620436 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 19995932 — Monitoring Biomarker (MOI): Alpha-1-acid glycoprotein 1
Genes: ORM1; AGP1
Study 24670704 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 12468337 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 12468337 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 29156909 — Pharmacodynamic Biomarker (PDY): Ataxin-2
Genes: ATXN2; ATX2; SCA2; TNRC13
Study 29156909 — Predictive Biomarker (PRD): AOAH mRNA
Genes: AOAH
Study 29156909 — Predictive Biomarker (PRD): GBGT1 mRNA
Genes: GBGT1; UNQ2513/PRO6002
Study 19884468 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9869347 — Surrogate Endpoint (SUR): Probing pocket depth
Study 8018978 — Safety Biomarker (SAF): N-acetylneuraminic acid
Study 2685599 — Surrogate Endpoint (SUR): Blood pressure
Study 2685599 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2685599 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15627789 — Predictive Biomarker (PRD): CGN mRNA
Genes: CGN; KIAA1319
Study 27126851 — Predictive Biomarker (PRD): 5HTT
Genes: SLC6A4; 5-HTT; SERT1
Study 27126851 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): FKBP5 mRNA
Genes: FKBP5; AIG6; FKBP51
Study 27126851 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 27126851 — Predictive Biomarker (PRD): ANKK1 mRNA
Genes: ANKK1; PKK2; SGK288
Study 8327595 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 3755281 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 27234671 — Surrogate Endpoint (SUR): Bone mineral density
Study 23291317 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 23291317 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10946527 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10946527 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9063919 — Surrogate Endpoint (SUR): Blood pressure
Study 29119331 — Predictive Biomarker (PRD): CRAT mRNA
Genes: CRAT; CAT1
Study 24974817 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 10852597 — Surrogate Endpoint (SUR): Serum creatinine
Study 23301476 — Predictive Biomarker (PRD): C4A mRNA
Genes: C4A; CO4; CPAMD2