TrialPanorama/TrialPanorama-database huggingface dataset:
Study 25871017 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25871017 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21142752 — Surrogate Endpoint (SUR): Blood pressure
Study 14707555 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 14707555 — Surrogate Endpoint (SUR): Blood pressure
Study 8996134 — Surrogate Endpoint (SUR): Serum calcium
Study 29750266 — Surrogate Endpoint (SUR): Serum uric acid
Study 25607338 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 25607338 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25607338 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 19077833 — Surrogate Endpoint (SUR): Blood pressure
Study 18578967 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15914522 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 15914522 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12872395 — Predictive Biomarker (PRD): ITGB2 mRNA
Genes: ITGB2; CD18; MFI7
Study 12872395 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 6330643 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 6330643 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 15680454 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 31677701 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 22990651 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 11910298 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11910298 — Surrogate Endpoint (SUR): Blood pressure
Study 8607111 — Safety Biomarker (SAF): Interleukin 1
Study 8607111 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 23859487 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 23859487 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7963412 — Safety Biomarker (SAF): Hyaluronic acid
Study 26006754 — Predictive Biomarker (PRD): LAMA1 mRNA
Genes: LAMA1; LAMA
Study 14995053 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31933278 — Predictive Biomarker (PRD): SLC40A1 mRNA
Genes: SLC40A1; FPN; FPN1; IREG1; SLC11A3; MSTP079
Study 31933278 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 31933278 — Predictive Biomarker (PRD): SLC11A2 mRNA
Genes: SLC11A2; DCT1; DMT1; NRAMP2; OK/SW-cl.20
Study 25175757 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17070175 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17070175 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12603503 — Predictive Biomarker (PRD): SERPINA1 mRNA
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209
Study 12556657 — Surrogate Endpoint (SUR): Blood pressure
Study 29725795 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 29725795 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 29725795 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 28629874 — Predictive Biomarker (PRD): C6orf15 mRNA
Genes: C6orf15; STG; UNQ1840/PRO3566
Study 2441202 — Surrogate Endpoint (SUR): Blood pressure
Study 21784377 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8397245 — Surrogate Endpoint (SUR): Blood pressure
Study 2427042 — Surrogate Endpoint (SUR): Serum calcium
Study 2427042 — Surrogate Endpoint (SUR): Serum creatinine
Study 22626879 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22626879 — Monitoring Biomarker (MOI): HBV DNA
Study 26895303 — Surrogate Endpoint (SUR): Blood pressure
Study 8778851 — Predictive Biomarker (PRD): MCAT mRNA
Genes: MCAT; MT
Study 2212376 — Surrogate Endpoint (SUR): Blood pressure
Study 30739385 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21675889 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 19291356 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 12768070 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12768070 — Surrogate Endpoint (SUR): Blood pressure
Study 11152056 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31102000 — Predictive Biomarker (PRD): FLT1 mRNA
Genes: FLT1; FLT; FRT; VEGFR1
Study 31102000 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 27334385 — Predictive Biomarker (PRD): FMR1 mRNA
Genes: FMR1
Study 27334385 — Surrogate Endpoint (SUR): Blood pressure
Study 20979935 — Predictive Biomarker (PRD): ELOVL6 mRNA
Genes: ELOVL6; FACE; LCE
Study 15961302 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 7786700 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28374645 — Safety Biomarker (SAF): DRD2
Study 31146613 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12215465 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12215465 — Surrogate Endpoint (SUR): Blood pressure
Study 2175140 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 2175140 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 2175140 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 2175140 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 25731923 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 15188172 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27934805 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 18926145 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16095140 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 11034945 — Predictive Biomarker (PRD): ATP1A1 mRNA
Genes: ATP1A1
Study 11034945 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 11034945 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HSD3B1 mRNA
Genes: HSD3B1; 3BH; HSDB3A
Study 11034945 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 11034945 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10319782 — Surrogate Endpoint (SUR): Blood pressure
Study 8952866 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29666135 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29666135 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 29666135 — Predictive Biomarker (PRD): ROS1 mRNA
Genes: ROS1; MCF3; ROS
Study 16282562 — Predictive Biomarker (PRD): TNFRSF1B mRNA
Genes: TNFRSF1B; TNFBR; TNFR2
Study 16282562 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16282562 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7832131 — Surrogate Endpoint (SUR): Blood pressure
Study 23644930 — Surrogate Endpoint (SUR): Bone mineral density
Study 19705288 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 3759224 — Surrogate Endpoint (SUR): Blood pressure
Study 3759224 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29020866 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 30923964 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 28462794 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 28462794 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 12957974 — Surrogate Endpoint (SUR): Blood pressure
Study 11056759 — Predictive Biomarker (PRD): CSF3 mRNA
Genes: CSF3; C17orf33; GCSF
Study 26802916 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 10533795 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 31746962 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31746962 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23715024 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 22276820 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 22276820 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 22276820 — Surrogate Endpoint (SUR): Pathological complete response
Study 22276820 — Predictive Biomarker (PRD): Hormone receptor
Study 2679036 — Surrogate Endpoint (SUR): Blood pressure
Study 1278069 — Surrogate Endpoint (SUR): Blood pressure
Study 12451428 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 12451428 — Surrogate Endpoint (SUR): Blood pressure
Study 26696199 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 19302563 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19302563 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 3886708 — Surrogate Endpoint (SUR): Blood pressure
Study 15753902 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 9806261 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 359018 — Surrogate Endpoint (SUR): Blood pressure
Study 26678511 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11157185 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11157185 — Surrogate Endpoint (SUR): Blood pressure
Study 8106965 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8044721 — Surrogate Endpoint (SUR): Blood pressure
Study 8044721 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28333301 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28333301 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9635370 — Predictive Biomarker (PRD): KITLG mRNA
Genes: KITLG; MGF; SCF
Study 7791682 — Surrogate Endpoint (SUR): Blood pressure
Study 2805603 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 2805603 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 29369454 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 22858557 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30849721 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30849721 — Surrogate Endpoint (SUR): Blood pressure
Study 30626863 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 30626863 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 15772568 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11958306 — Predictive Biomarker (PRD): PNP mRNA
Genes: PNP; NP
Study 20051371 — Predictive Biomarker (PRD): SLC25A21 mRNA
Genes: SLC25A21; ODC
Study 9296896 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 8320928 — Surrogate Endpoint (SUR): Blood pressure
Study 22276959 — Predictive Biomarker (PRD): DBI mRNA
Genes: DBI
Study 12575905 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12575905 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 19061694 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30748011 — Surrogate Endpoint (SUR): Bone mineral density
Study 28734759 — Predictive Biomarker (PRD): Microsatellite instability
Study 10554734 — Surrogate Endpoint (SUR): Blood pressure
Study 9093645 — Surrogate Endpoint (SUR): Blood pressure
Study 28888762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28888762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10639356 — Predictive Biomarker (PRD): NR4A3 mRNA
Genes: NR4A3; CHN; CSMF; MINOR; NOR1; TEC
Study 30234853 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 24574902 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 18001879 — Predictive Biomarker (PRD): KDM5D mRNA
Genes: KDM5D; HY; HYA; JARID1D; KIAA0234; SMCY
Study 16708806 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10319783 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 30535218 — Predictive Biomarker (PRD): CLCN1 mRNA
Genes: CLCN1; CLC1
Study 30535218 — Predictive Biomarker (PRD): SCN4A mRNA
Genes: SCN4A
Study 15302800 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15302800 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15302800 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 11967252 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11967252 — Surrogate Endpoint (SUR): Blood pressure
Study 11967252 — Surrogate Endpoint (SUR): Serum creatinine
Study 9718249 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 129494 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 15233807 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15233807 — Surrogate Endpoint (SUR): Blood pressure
Study 15233807 — Surrogate Endpoint (SUR): Serum uric acid
Study 3300248 — Surrogate Endpoint (SUR): Blood pressure
Study 16101362 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 12116341 — Predictive Biomarker (PRD): Lymphocyte activation antigen CD30
Genes: TNFRSF8; CD30; D1S166E
Study 12116341 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 12116341 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12116341 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 6377793 — Surrogate Endpoint (SUR): Blood pressure
Study 27470399 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27470399 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 23180520 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 20492467 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 12427060 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 23761651 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23761651 — Surrogate Endpoint (SUR): Blood pressure
Study 23761651 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23761651 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 20422422 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 10653205 — Surrogate Endpoint (SUR): Blood pressure
Study 8843209 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8843209 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8843209 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 6711468 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31368267 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 8983866 — Surrogate Endpoint (SUR): Blood pressure
Study 19719472 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 19719472 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 26239595 — Pharmacodynamic Biomarker (PDY): Transmembrane glycoprotein NMB
Genes: GPNMB; HGFIN; NMB; UNQ1725/PRO9925
Study 26407878 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 25630513 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 15723964 — Surrogate Endpoint (SUR): Blood pressure
Study 31030363 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9073002 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 7923728 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 3018603 — Surrogate Endpoint (SUR): Blood pressure
Study 3018603 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17484080 — Surrogate Endpoint (SUR): Serum creatinine
Study 25287767 — Surrogate Endpoint (SUR): Blood pressure
Study 15878000 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11328289 — Predictive Biomarker (PRD): ETV6 mRNA
Genes: ETV6; TEL; TEL1
Study 11328289 — Predictive Biomarker (PRD): RUNX1 mRNA
Genes: RUNX1; AML1; CBFA2
Study 27658130 — Surrogate Endpoint (SUR): Blood pressure
Study 24209423 — Surrogate Endpoint (SUR): Blood pressure
Study 12519844 — Surrogate Endpoint (SUR): Serum testosterone
Study 6140440 — Surrogate Endpoint (SUR): Blood pressure
Study 19549615 — Predictive Biomarker (PRD): MAVS mRNA
Genes: MAVS; IPS1; KIAA1271; VISA
Study 19165197 — Predictive Biomarker (PRD): MLH1 mRNA
Genes: MLH1; COCA2
Study 19165197 — Predictive Biomarker (PRD): Microsatellite instability
Study 16696522 — Surrogate Endpoint (SUR): Blood pressure
Study 24965494 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 23077137 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 18565950 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 6630409 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 24933232 — Predictive Biomarker (PRD): AGER mRNA
Genes: AGER; RAGE
Study 21816443 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21816443 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25967705 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 21839455 — Surrogate Endpoint (SUR): Blood pressure
Study 15053895 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15053895 — Predictive Biomarker (PRD): GAD2 mRNA
Genes: GAD2; GAD65
Study 9089564 — Surrogate Endpoint (SUR): Bone mineral density
Study 29644504 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 25385173 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 25385173 — Predictive Biomarker (PRD): miR-31
Genes: MIR31
Study 25385173 — Safety Biomarker (SAF): miR-181a
Study 25385173 — Safety Biomarker (SAF): miR-16
Study 25385173 — Predictive Biomarker (PRD): miR-145
Genes: MIR145
Study 23523162 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 23523162 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 23523162 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 23523162 — Predictive Biomarker (PRD): CFHR5 mRNA
Genes: CFHR5; CFHL5; FHR5
Study 23523162 — Predictive Biomarker (PRD): F13B mRNA
Genes: F13B
Study 21701080 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21701080 — Surrogate Endpoint (SUR): Blood pressure
Study 19623684 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19623684 — Surrogate Endpoint (SUR): Blood pressure
Study 14639093 — Surrogate Endpoint (SUR): Blood pressure
Study 9547443 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9547443 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 12891198 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 8911832 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8388090 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31662331 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31662331 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 25518506 — Surrogate Endpoint (SUR): Blood pressure
Study 22507264 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12504838 — Surrogate Endpoint (SUR): Blood pressure
Study 21986689 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21986689 — Predictive Biomarker (PRD): IK mRNA
Genes: IK; RED; RER
Study 19531038 — Surrogate Endpoint (SUR): Blood pressure
Study 12867583 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 25011693 — Surrogate Endpoint (SUR): Blood pressure
Study 17629471 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10928294 — Surrogate Endpoint (SUR): Blood pressure
Study 24985574 — Pharmacodynamic Biomarker (PDY): Human leukocyte antigen DR
Study 24985574 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 22840583 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 22840583 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22840583 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17656221 — Surrogate Endpoint (SUR): Bone mineral density
Study 31830885 — Safety Biomarker (SAF): Reactive oxygen species
Study 29727544 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 19950808 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31618812 — Predictive Biomarker (PRD): ABCA4 mRNA
Genes: ABCA4; ABCR
Study 21570617 — Surrogate Endpoint (SUR): Blood pressure
Study 17163356 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8067602 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 24094767 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 24094767 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 7527733 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 7527733 — Predictive Biomarker (PRD): REG3A mRNA
Genes: REG3A; HIP; PAP; PAP1
Study 23220425 — Surrogate Endpoint (SUR): Serum creatinine
Study 15084240 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 24760656 — Surrogate Endpoint (SUR): Blood pressure