TrialPanorama/TrialPanorama-database huggingface dataset:
Study 21865358 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21865358 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15342804 — Predictive Biomarker (PRD): Hormone receptor
Study 9377992 — Surrogate Endpoint (SUR): Blood pressure
Study 3732422 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21322822 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 12784165 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12784165 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8681491 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21376050 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 17032921 — Predictive Biomarker (PRD): CR1 mRNA
Genes: CR1; C3BR
Study 15326083 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7613555 — Surrogate Endpoint (SUR): Forced vital capacity
Study 6282482 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21142856 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 8112373 — Surrogate Endpoint (SUR): Blood pressure
Study 24973875 — Surrogate Endpoint (SUR): Blood pressure
Study 26079469 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 9649259 — Surrogate Endpoint (SUR): Serum testosterone
Study 6848894 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23201472 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 23201472 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 3124940 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 20581879 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 8941092 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 74660 — Surrogate Endpoint (SUR): Blood pressure
Study 19200175 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 9037327 — Surrogate Endpoint (SUR): Blood pressure
Study 26180052 — Predictive Biomarker (PRD): LTA mRNA
Genes: LTA; TNFB; TNFSF1
Study 2060176 — Surrogate Endpoint (SUR): Bone mineral density
Study 31752105 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 28893753 — Predictive Biomarker (PRD): PTS mRNA
Genes: PTS
Study 12218949 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 31495898 — Predictive Biomarker (PRD): PPL mRNA
Genes: PPL; KIAA0568
Study 28526014 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28526014 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8652960 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 2221287 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 30193574 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30193574 — Surrogate Endpoint (SUR): Blood pressure
Study 10786744 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10786744 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9483214 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 9483214 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 9483214 — Predictive Biomarker (PRD): CD44 mRNA
Genes: CD44; LHR; MDU2; MDU3; MIC4
Study 9483214 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 24676848 — Surrogate Endpoint (SUR): Bone mineral density
Study 22172728 — Surrogate Endpoint (SUR): Blood pressure
Study 22172728 — Surrogate Endpoint (SUR): Serum potassium
Study 7583899 — Surrogate Endpoint (SUR): Blood pressure
Study 2182976 — Surrogate Endpoint (SUR): Bone mineral density
Study 2182976 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 17188618 — Predictive Biomarker (PRD): CYCS mRNA
Genes: CYCS; CYC
Study 11463766 — Surrogate Endpoint (SUR): Blood pressure
Study 26234407 — Predictive Biomarker (PRD): ISG15 mRNA
Genes: ISG15; G1P2; UCRP
Study 21248785 — Surrogate Endpoint (SUR): Blood pressure
Study 28872484 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 26599904 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 15671570 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 7753338 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 20056802 — Surrogate Endpoint (SUR): Blood pressure
Study 18566455 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 11840226 — Surrogate Endpoint (SUR): Blood pressure
Study 10512130 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 25481936 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25481936 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17559733 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 9766535 — Surrogate Endpoint (SUR): Blood pressure
Study 7548903 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2247767 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2247767 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 2247767 — Surrogate Endpoint (SUR): Blood pressure
Study 7004473 — Surrogate Endpoint (SUR): Blood pressure
Study 26842122 — Predictive Biomarker (PRD): CENPJ mRNA
Genes: CENPJ; CPAP; LAP; LIP1
Study 24628577 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 21848848 — Predictive Biomarker (PRD): CFB mRNA
Genes: CFB; BF; BFD
Study 19647866 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15223897 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11880014 — Surrogate Endpoint (SUR): Serum potassium
Study 2226911 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2226911 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30001712 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 23319466 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 12042618 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 22729966 — Surrogate Endpoint (SUR): Blood pressure
Study 16860174 — Surrogate Endpoint (SUR): Bone mineral density
Study 3063798 — Surrogate Endpoint (SUR): Blood pressure
Study 31053766 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 31053766 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 18425402 — Surrogate Endpoint (SUR): Serum calcium
Study 10792338 — Surrogate Endpoint (SUR): Serum testosterone
Study 26658900 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26658900 — Predictive Biomarker (PRD): NR1H2 mRNA
Genes: NR1H2; LXRB; NER; UNR
Study 26658900 — Predictive Biomarker (PRD): CXCR1 mRNA
Genes: CXCR1; CMKAR1; IL8RA
Study 26658900 — Surrogate Endpoint (SUR): Blood pressure
Study 15080356 — Surrogate Endpoint (SUR): Blood pressure
Study 16949487 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10972169 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 25305179 — Predictive Biomarker (PRD): TRPV1 mRNA
Genes: TRPV1; VR1
Study 22492374 — Safety Biomarker (SAF): MTHFR
Study 20388073 — Safety Biomarker (SAF): Hyaluronic acid
Study 19954060 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7681510 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7681510 — Surrogate Endpoint (SUR): Blood pressure
Study 31721089 — Predictive Biomarker (PRD): IDE mRNA
Genes: IDE
Study 26201085 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26201085 — Monitoring Biomarker (MOI): Complement C4
Study 26201085 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26201085 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26201085 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 26201085 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 20225994 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 27859478 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 26255012 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 12577391 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 2439781 — Surrogate Endpoint (SUR): Blood pressure
Study 21169260 — Safety Biomarker (SAF): Glutathione S-transferase P
Genes: GSTP1; FAEES3; GST3
Study 26869678 — Surrogate Endpoint (SUR): Forced vital capacity
Study 17825197 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19151286 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19151286 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 19151286 — Surrogate Endpoint (SUR): Blood pressure
Study 11923552 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 175146 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 17988379 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 17988379 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17988379 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17988379 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28727955 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30897303 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24736801 — Predictive Biomarker (PRD): DHPS mRNA
Genes: DHPS; DS
Study 22304968 — Predictive Biomarker (PRD): PICALM mRNA
Genes: PICALM; CALM
Study 22304968 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 25716777 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25716777 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 25716777 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25716777 — Safety Biomarker (SAF): BDNF
Study 23475700 — Surrogate Endpoint (SUR): Blood pressure
Study 14633525 — Surrogate Endpoint (SUR): Serum sodium
Study 27058233 — Predictive Biomarker (PRD): Hormone receptor
Study 17882870 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10451015 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 31937528 — Surrogate Endpoint (SUR): Blood pressure
Study 26251920 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26251920 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26251920 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26251920 — Safety Biomarker (SAF): Interleukin 1
Study 23433768 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 23433768 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6611576 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TNS1 mRNA
Genes: TNS1; TNS
Study 17696230 — Monitoring Biomarker (MOI): HBV DNA
Study 27095187 — Predictive Biomarker (PRD): PPP1R13L mRNA
Genes: PPP1R13L; IASPP; NKIP1; PPP1R13BL; RAI
Study 19515739 — Surrogate Endpoint (SUR): Blood pressure
Study 19515739 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25287156 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20063135 — Surrogate Endpoint (SUR): Blood pressure
Study 22868657 — Surrogate Endpoint (SUR): Bone mineral density
Study 10845879 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 10845879 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10845879 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 26238113 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26238113 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 26238113 — Surrogate Endpoint (SUR): Blood pressure
Study 18837771 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18837771 — Surrogate Endpoint (SUR): Serum creatinine
Study 17076223 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28678111 — Predictive Biomarker (PRD): SLC4A7 mRNA
Genes: SLC4A7; BT; NBC2; NBC2B; NBC3; NBCn1; SBC2; SLC4A6
Study 16649881 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 10895397 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 1378685 — Surrogate Endpoint (SUR): Blood pressure
Study 31752756 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 24889731 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 9928856 — Monitoring Biomarker (MOI): Procalcitonin
Study 31385880 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31385880 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 23760160 — Pharmacodynamic Biomarker (PDY): Mitochondrial membrane potential
Study 9254071 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 9254071 — Predictive Biomarker (PRD): EVA1A mRNA
Genes: EVA1A; FAM176A; TMEM166; SP24
Study 31552541 — Predictive Biomarker (PRD): PPT1 mRNA
Genes: PPT1; CLN1; PPT
Study 27565230 — Predictive Biomarker (PRD): Hormone receptor
Study 27565230 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25473210 — Safety Biomarker (SAF): Hyaluronic acid
Study 19337387 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 3361170 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 3361170 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 22616770 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 12665684 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 11024374 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 25550188 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 19692688 — Predictive Biomarker (PRD): Hormone receptor
Study 3912335 — Surrogate Endpoint (SUR): Blood pressure
Study 17159456 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 17159456 — Predictive Biomarker (PRD): IL2
Genes: IL-2; TCGF
Study 11487379 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11487379 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 9763328 — Surrogate Endpoint (SUR): Probing pocket depth
Study 21820084 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18075221 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9150779 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 3323648 — Surrogate Endpoint (SUR): Serum creatinine
Study 29473353 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 29473353 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 29477262 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 29477262 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 29477262 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 27393697 — Surrogate Endpoint (SUR): Serum triglycerides
Study 20420943 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Osteopontin
Genes: SPP1; BNSP; OPN; PSEC0156
Study 26265727 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 22522786 — Surrogate Endpoint (SUR): Blood pressure
Study 11861264 — Surrogate Endpoint (SUR): Hematologic response
Study 30540657 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30540657 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 30540657 — Surrogate Endpoint (SUR): Blood pressure
Study 24643755 — Predictive Biomarker (PRD): UCP2 mRNA
Genes: UCP2; SLC25A8
Study 24643755 — Predictive Biomarker (PRD): UCP3 mRNA
Genes: UCP3; SLC25A9
Study 24643755 — Safety Biomarker (SAF): Reactive oxygen species
Study 24643755 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 23219310 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 9418642 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 28029114 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 25011384 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19190821 — Predictive Biomarker (PRD): ADRB2 mRNA
Genes: ADRB2; ADRB2R; B2AR
Study 15158621 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 15158621 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 15158621 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 15158621 — Safety Biomarker (SAF): Reactive oxygen species
Study 15158621 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 27670154 — Surrogate Endpoint (SUR): Serum calcium
Study 23701202 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 16542207 — Predictive Biomarker (PRD): Indoleamine 2,3-dioxygenase 1
Genes: IDO1; IDO; INDO
Study 11180036 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 9597123 — Safety Biomarker (SAF): Interleukin 1
Study 8199179 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2452393 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19615804 — Surrogate Endpoint (SUR): Serum creatinine
Study 11741827 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11741827 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 26561628 — Surrogate Endpoint (SUR): Blood pressure
Study 1699088 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 31896121 — Surrogate Endpoint (SUR): Plasma ammonia
Study 17179108 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11076325 — Predictive Biomarker (PRD): NBN mRNA
Genes: NBN; NBS; NBS1; P95
Study 3908782 — Safety Biomarker (SAF): BCHE
Genes: E1
Study 31941260 — Surrogate Endpoint (SUR): Serum creatinine
Study 31941260 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 18479353 — Surrogate Endpoint (SUR): Urinary oxalate
Study 8949315 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31780765 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 31780765 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 26350480 — Surrogate Endpoint (SUR): Blood pressure
Study 21823222 — Safety Biomarker (SAF): Nicotinamide phosphoribosyltransferase
Genes: NAMPT; PBEF; PBEF1
Study 27310328 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 22653713 — Surrogate Endpoint (SUR): Bone mineral density
Study 11318020 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11318020 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 8487059 — Predictive Biomarker (PRD): SRM mRNA
Genes: SRM; SPS1; SRML1
Study 3122629 — Surrogate Endpoint (SUR): Blood pressure
Study 14679493 — Surrogate Endpoint (SUR): Forced vital capacity
Study 3396546 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 19110600 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 8347899 — Surrogate Endpoint (SUR): Serum creatinine
Study 28988341 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 28988341 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 27529317 — Surrogate Endpoint (SUR): Blood pressure
Study 22154769 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 17682988 — Surrogate Endpoint (SUR): Serum creatinine
Study 24232701 — Surrogate Endpoint (SUR): Forced vital capacity
Study 7774989 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19157547 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 17086362 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15150954 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28237426 — Predictive Biomarker (PRD): RPE65 mRNA
Genes: RPE65
Study 25812482 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 29725975 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 27430216 — Surrogate Endpoint (SUR): Serum creatinine
Study 10660004 — Surrogate Endpoint (SUR): Blood pressure
Study 1353642 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6650492 — Surrogate Endpoint (SUR): Serum sodium
Study 22917555 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29197871 — Predictive Biomarker (PRD): GLS mRNA
Genes: GLS; GLS1; KIAA0838
Study 29197871 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 23589672 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9623424 — Surrogate Endpoint (SUR): Forced vital capacity
Study 30394153 — Predictive Biomarker (PRD): AFM mRNA
Genes: AFM; ALB2; ALBA
Study 21458598 — Surrogate Endpoint (SUR): Blood pressure
Study 10893367 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 24725763 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22340556 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 20930431 — Surrogate Endpoint (SUR): Bone mineral density
Study 22106246 — Surrogate Endpoint (SUR): Serum creatinine
Study 10338322 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 10338322 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 7796076 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 2326330 — Surrogate Endpoint (SUR): Blood pressure
Study 16924006 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 11057790 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 31490424 — Predictive Biomarker (PRD): CHAF1A mRNA
Genes: CHAF1A; CAF; CAF1P150