TrialPanorama/TrialPanorama-database huggingface dataset:
Study 10522582 — Surrogate Endpoint (SUR): Blood pressure
Study 1931867 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16798785 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 9378531 — Predictive Biomarker (PRD): ABO mRNA
Genes: ABO
Study 9378531 — Predictive Biomarker (PRD): SLC14A1 mRNA
Genes: SLC14A1; HUT11; JK; RACH1; UT1; UTE
Study 23135172 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15200045 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 1773691 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1773691 — Surrogate Endpoint (SUR): Blood pressure
Study 1773691 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31529295 — Predictive Biomarker (PRD): MGP mRNA
Genes: MGP; MGLAP; GIG36
Study 22412143 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 7523131 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 18194800 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 14566252 — Surrogate Endpoint (SUR): Serum creatinine
Study 11168342 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 11168342 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 25759106 — Surrogate Endpoint (SUR): Serum creatinine
Study 23843932 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 2006663 — Surrogate Endpoint (SUR): Blood pressure
Study 16831185 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 27680390 — Surrogate Endpoint (SUR): Blood pressure
Study 20386344 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 11199863 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 8329024 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24814231 — Surrogate Endpoint (SUR): Blood pressure
Study 22858558 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 22858558 — Surrogate Endpoint (SUR): Blood pressure
Study 10397076 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 10397076 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 2582726 — Surrogate Endpoint (SUR): Blood pressure
Study 30802725 — Surrogate Endpoint (SUR): Blood pressure
Study 1541312 — Surrogate Endpoint (SUR): Blood pressure
Study 16037751 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8635038 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 25112865 — Monitoring Biomarker (MOI): Mitochondrial frataxin
Genes: FXN; FRDA; X25
Study 22747998 — Surrogate Endpoint (SUR): Blood pressure
Study 15640479 — Surrogate Endpoint (SUR): Blood pressure
Study 9950598 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9950598 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 31415381 — Monitoring Biomarker (MOI): HBV DNA
Study 26044169 — Predictive Biomarker (PRD): TLR7 mRNA
Genes: TLR7; UNQ248/PRO285
Study 23432466 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11289347 — Surrogate Endpoint (SUR): Serum creatinine
Study 9923089 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 23770179 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23770179 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20185616 — Pharmacodynamic Biomarker (PDY): Platelet-derived growth factor B
Genes: PDGFB; PDGF2; SIS
Study 18286595 — Safety Biomarker (SAF): L-acetylcarnitine
Study 14583175 — Surrogate Endpoint (SUR): Blood pressure
Study 10555125 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 17399725 — Surrogate Endpoint (SUR): Bone mineral density
Study 7924325 — Predictive Biomarker (PRD): NOG mRNA
Genes: NOG
Study 23835594 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 20888653 — Surrogate Endpoint (SUR): Blood pressure
Study 15363656 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 8127015 — Surrogate Endpoint (SUR): Bone mineral density
Study 28657604 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 25279689 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 27031850 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 11528361 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11528361 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 11528361 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 26620248 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 26620248 — Surrogate Endpoint (SUR): Blood pressure
Study 11057934 — Surrogate Endpoint (SUR): Serum creatinine
Study 19102857 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 23252455 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 19138577 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 12622322 — Surrogate Endpoint (SUR): Blood pressure
Study 24737541 — Surrogate Endpoint (SUR): Pathological complete response
Study 12545143 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 2581099 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19100010 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 19100010 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 19100010 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16371736 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 16371736 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29504705 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 27779454 — Surrogate Endpoint (SUR): Blood pressure
Study 19478674 — Surrogate Endpoint (SUR): Blood pressure
Study 11137759 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 3024959 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 31539295 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 31539295 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31539295 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 31539295 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 31539295 — Predictive Biomarker (PRD): ROS1 mRNA
Genes: ROS1; MCF3; ROS
Study 31539295 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 31539295 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 31539295 — Predictive Biomarker (PRD): AKT1 mRNA
Genes: AKT1; PKB; RAC
Study 31539295 — Predictive Biomarker (PRD): Microsatellite instability
Study 25029875 — Surrogate Endpoint (SUR): Blood pressure
Study 16579084 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 21091269 — Surrogate Endpoint (SUR): Blood pressure
Study 28580833 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19030909 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 16461040 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28888268 — Surrogate Endpoint (SUR): Blood pressure
Study 28888268 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22179922 — Surrogate Endpoint (SUR): Blood pressure
Study 16794456 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16794456 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16794456 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 21672339 — Surrogate Endpoint (SUR): Blood pressure
Study 26930839 — Surrogate Endpoint (SUR): Blood pressure
Study 12929147 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 8491505 — Surrogate Endpoint (SUR): Blood pressure
Study 31552706 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31552706 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 31552706 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 22618893 — Predictive Biomarker (PRD): ASRGL1 mRNA
Genes: ASRGL1; ALP; CRASH
Study 15689053 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15689053 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15689053 — Surrogate Endpoint (SUR): Blood pressure
Study 2891285 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 26447636 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 21326328 — Surrogate Endpoint (SUR): Blood pressure
Study 19559792 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 7827298 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 3045025 — Surrogate Endpoint (SUR): Blood pressure
Study 18398105 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 20698837 — Predictive Biomarker (PRD): GABRA2 mRNA
Genes: GABRA2
Study 16953394 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9249269 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19596331 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19596331 — Surrogate Endpoint (SUR): Serum creatinine
Study 16470487 — Surrogate Endpoint (SUR): Blood pressure
Study 7554701 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 28486692 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 23812464 — Surrogate Endpoint (SUR): Bone mineral density
Study 3042355 — Surrogate Endpoint (SUR): Blood pressure
Study 29945395 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 29945395 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 29945395 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 22828090 — Surrogate Endpoint (SUR): Blood pressure
Study 19765266 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 19765266 — Surrogate Endpoint (SUR): Serum triglycerides
Study 30665439 — Safety Biomarker (SAF): Reactive oxygen species
Study 30665439 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30665439 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30665439 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 24172652 — Predictive Biomarker (PRD): TAL1 mRNA
Genes: TAL1; BHLHA17; SCL; TCL5
Study 2704504 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25345840 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25345840 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 23539110 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 19155456 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 11277342 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11277342 — Surrogate Endpoint (SUR): Blood pressure
Study 25300874 — Surrogate Endpoint (SUR): Blood pressure
Study 15920041 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 31961494 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20005697 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 16650578 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 16650578 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17656473 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 16273458 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 7491817 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 529340 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 31831203 — Predictive Biomarker (PRD): AANAT mRNA
Genes: AANAT; SNAT
Study 28237539 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 28237539 — Predictive Biomarker (PRD): NRAS mRNA
Genes: NRAS; HRAS1
Study 28237539 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 28237539 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 28237539 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 18219661 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 15965818 — Monitoring Biomarker (MOI): Matrix metalloproteinase 1
Genes: MMP1; CLG
Study 15965818 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 7138632 — Surrogate Endpoint (SUR): Blood pressure
Study 26591552 — Predictive Biomarker (PRD): ERF mRNA
Genes: ERF
Study 26591552 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26591552 — Surrogate Endpoint (SUR): Blood pressure
Study 21528639 — Surrogate Endpoint (SUR): Blood pressure
Study 16534013 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12507703 — Surrogate Endpoint (SUR): Blood pressure
Study 24694531 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 24694531 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23713082 — Surrogate Endpoint (SUR): Serum potassium
Study 23713082 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16629794 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 16629794 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 10933177 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 23192844 — Predictive Biomarker (PRD): CD44 mRNA
Genes: CD44; LHR; MDU2; MDU3; MIC4
Study 23192844 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 23192844 — Predictive Biomarker (PRD): Hormone receptor
Study 15804591 — Surrogate Endpoint (SUR): Blood pressure
Study 12858407 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2756879 — Surrogate Endpoint (SUR): Blood pressure
Study 18661061 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 31622456 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19267842 — Safety Biomarker (SAF): Hyaluronic acid
Study 11099053 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 22759255 — Safety Biomarker (SAF): Hyaluronic acid
Study 20041473 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 17922883 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 398184 — Surrogate Endpoint (SUR): Blood pressure
Study 31232920 — Predictive Biomarker (PRD): F7 mRNA
Genes: F7
Study 25050491 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 15649877 — Surrogate Endpoint (SUR): Blood pressure
Study 9809626 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9809626 — Safety Biomarker (SAF): Interleukin 1
Study 31623611 — Predictive Biomarker (PRD): NOCT mRNA
Genes: NOCT; CCR4; CCRN4L; NOC
Study 27654259 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 24463451 — Surrogate Endpoint (SUR): Bone mineral density
Study 11948051 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 11948051 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 29209926 — Surrogate Endpoint (SUR): Blood pressure
Study 20845670 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 20845670 — Safety Biomarker (SAF): Reactive oxygen species
Study 18219299 — Surrogate Endpoint (SUR): Blood pressure
Study 18219299 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20370419 — Monitoring Biomarker (MOI): Matrix metalloproteinase 8
Genes: MMP8; CLG1
Study 20370419 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12684289 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 31010449 — Predictive Biomarker (PRD): COPE mRNA
Genes: COPE
Study 24690571 — Surrogate Endpoint (SUR): Blood pressure
Study 22240353 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17549295 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 12123487 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12123487 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1636617 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1636617 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31479306 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19897461 — Predictive Biomarker (PRD): CFI mRNA
Genes: CFI; IF
Study 12383039 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 27562731 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 17081398 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12681023 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 29328007 — Surrogate Endpoint (SUR): Serum creatinine
Study 20178647 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 7548480 — Surrogate Endpoint (SUR): Blood pressure
Study 347110 — Surrogate Endpoint (SUR): Blood pressure
Study 27629597 — Predictive Biomarker (PRD): DRD4 mRNA
Genes: DRD4
Study 27629597 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 27629597 — Predictive Biomarker (PRD): SLC6A3 mRNA
Genes: SLC6A3; DAT1
Study 27629597 — Predictive Biomarker (PRD): MAOA mRNA
Genes: MAOA
Study 27629597 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 20546573 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 11040246 — Surrogate Endpoint (SUR): Blood pressure
Study 23610561 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 24299662 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17494794 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 17494794 — Predictive Biomarker (PRD): CFTR
Genes: MRP7; ABC35; TNR-CFTR; dJ760C5.1; CFTR/MRP
Study 27587282 — Surrogate Endpoint (SUR): Blood pressure
Study 27587282 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2404429 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2404429 — Surrogate Endpoint (SUR): Blood pressure
Study 392621 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 21311216 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 11282905 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 11282905 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7840400 — Surrogate Endpoint (SUR): Blood pressure
Study 22202544 — Surrogate Endpoint (SUR): Blood pressure
Study 20497292 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20497292 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30146344 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 30146344 — Surrogate Endpoint (SUR): Forced vital capacity
Study 30146344 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 24627552 — Surrogate Endpoint (SUR): Blood pressure
Study 8907442 — Surrogate Endpoint (SUR): Blood pressure
Study 21908204 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21908204 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21908204 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11253475 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 8616303 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8616303 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23756586 — Surrogate Endpoint (SUR): Blood pressure
Study 16029400 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16029400 — Surrogate Endpoint (SUR): Blood pressure
Study 2066053 — Surrogate Endpoint (SUR): Serum creatinine
Study 29374667 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20427750 — Predictive Biomarker (PRD): FXYD1 mRNA
Genes: FXYD1; PLM
Study 31645451 — Predictive Biomarker (PRD): CXCR1 mRNA
Genes: CXCR1; CMKAR1; IL8RA
Study 29798192 — Pharmacodynamic Biomarker (PDY): Amyloid beta peptide (1-40)
Genes: APP; A4; AD1
Study 18650162 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 18650162 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 16569044 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22866361 — Surrogate Endpoint (SUR): Blood pressure
Study 28728606 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28728606 — Safety Biomarker (SAF): Hyaluronic acid
Study 28728606 — Monitoring Biomarker (MOI): Matrix metalloproteinase 1
Genes: MMP1; CLG
Study 28728606 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 16955450 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 22228773 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10430967 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 10430967 — Surrogate Endpoint (SUR): Blood pressure
Study 8699846 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8699846 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 2347957 — Surrogate Endpoint (SUR): Plasma phenylalanine