TrialPanorama/TrialPanorama-database huggingface dataset:
Study 19562253 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19562253 — Safety Biomarker (SAF): IL-6 and IL-10
Study 17415706 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 25413896 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21353463 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 15497369 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 22000423 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 19324483 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 16964676 — Monitoring Biomarker (MOI): HBV DNA
Study 1570887 — Surrogate Endpoint (SUR): Blood pressure
Study 29948863 — Surrogate Endpoint (SUR): Serum creatinine
Study 24505249 — Predictive Biomarker (PRD): CCN2 mRNA
Genes: CCN2; CTGF; HCS24; IGFBP8
Study 24505249 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24505249 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8119688 — Safety Biomarker (SAF): Hyaluronic acid
Study 1092516 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 27706121 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 31787369 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 27832260 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27832260 — Predictive Biomarker (PRD): Hormone receptor
Study 23595134 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 16824986 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 12624284 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 12624284 — Predictive Biomarker (PRD): S100B mRNA
Genes: S100B
Study 2943594 — Surrogate Endpoint (SUR): Blood pressure
Study 25366952 — Surrogate Endpoint (SUR): Serum creatinine
Study 17641591 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 14503056 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 9346990 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 23803593 — Surrogate Endpoint (SUR): Blood pressure
Study 22463944 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18953177 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 18953177 — Predictive Biomarker (PRD): SERPINA5 mRNA
Genes: SERPINA5; PCI; PLANH3; PROCI
Study 18953177 — Safety Biomarker (SAF): Vitamin K-dependent protein C
Genes: PROC
Study 18953177 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 18953177 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 1997518 — Surrogate Endpoint (SUR): Blood pressure
Study 31446992 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 26844688 — Surrogate Endpoint (SUR): Bone mineral density
Study 26844688 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 1641292 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 1641292 — Monitoring Biomarker (MOI): HBV DNA
Study 26316741 — Surrogate Endpoint (SUR): Forced vital capacity
Study 6310996 — Surrogate Endpoint (SUR): Serum creatinine
Study 24888488 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20530973 — Predictive Biomarker (PRD): Hormone receptor
Study 18613793 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18613793 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16485513 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8949568 — Surrogate Endpoint (SUR): Blood pressure
Study 31072023 — Predictive Biomarker (PRD): NOCT mRNA
Genes: NOCT; CCR4; CCRN4L; NOC
Study 25710276 — Predictive Biomarker (PRD): BAK1 mRNA
Genes: BAK1; BAK; BCL2L7; CDN1
Study 21570522 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21570522 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17623345 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15580811 — Surrogate Endpoint (SUR): Blood pressure
Study 7989939 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 28314744 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 22959395 — Predictive Biomarker (PRD): MVP mRNA
Genes: MVP; LRP
Study 21982664 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 21982664 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21982664 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12709465 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 12709465 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12709465 — Surrogate Endpoint (SUR): Blood pressure
Study 3003298 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 3003298 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 3003298 — Predictive Biomarker (PRD): ABCD1 mRNA
Genes: ABCD1; ALD
Study 3003298 — Surrogate Endpoint (SUR): Blood pressure
Study 31510831 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31510831 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24317794 — Predictive Biomarker (PRD): PPARGC1A mRNA
Genes: PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1
Study 24317794 — Predictive Biomarker (PRD): PPARGC1B mRNA
Genes: PPARGC1B; PERC; PGC1; PGC1B; PPARGC1
Study 30785496 — Surrogate Endpoint (SUR): Serum triglycerides
Study 29392288 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25731901 — Safety Biomarker (SAF): Glutamate dehydrogenase
Study 21058473 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 17558118 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2291868 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31112385 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 24447181 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 15636619 — Predictive Biomarker (PRD): CSF3 mRNA
Genes: CSF3; C17orf33; GCSF
Study 25733246 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16508637 — Predictive Biomarker (PRD): MCC mRNA
Genes: MCC
Study 11095480 — Predictive Biomarker (PRD): STK11 mRNA
Genes: STK11; LKB1; PJS
Study 28634217 — Surrogate Endpoint (SUR): Blood pressure
Study 21350366 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18637980 — Surrogate Endpoint (SUR): Blood pressure
Study 15569067 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 23664208 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 23664208 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 1280735 — Surrogate Endpoint (SUR): Blood pressure
Study 30366815 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 30366815 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 27132170 — Monitoring Biomarker (MOI): HBV DNA
Study 21082868 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 21082868 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21082868 — Surrogate Endpoint (SUR): Blood pressure
Study 11431944 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 22840421 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 15877873 — Surrogate Endpoint (SUR): Blood pressure
Study 24488610 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 10839333 — Safety Biomarker (SAF): DRD2
Study 24470557 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 24470557 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 24470557 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 15507508 — Surrogate Endpoint (SUR): Bone mineral density
Study 1518261 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 30557128 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18647851 — Predictive Biomarker (PRD): MMP13 mRNA
Genes: MMP13
Study 26429571 — Safety Biomarker (SAF): Interleukin 1
Study 11686867 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 9197292 — Safety Biomarker (SAF): Alpha-glutathione S-transferase
Study 9197292 — Surrogate Endpoint (SUR): Serum creatinine
Study 19427680 — Predictive Biomarker (PRD): ADAMTS13 mRNA
Genes: ADAMTS13; C9orf8; UNQ6102/PRO20085
Study 31778439 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 11686808 — Surrogate Endpoint (SUR): Probing pocket depth
Study 28825891 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 15725986 — Surrogate Endpoint (SUR): Bone mineral density
Study 10376694 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 10376694 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 30938809 — Predictive Biomarker (PRD): DHPS mRNA
Genes: DHPS; DS
Study 11471515 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30553555 — Surrogate Endpoint (SUR): Blood pressure
Study 9404441 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 9404441 — Surrogate Endpoint (SUR): Bone mineral density
Study 3126455 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 24060588 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 12812689 — Surrogate Endpoint (SUR): Blood pressure
Study 10565607 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 6110188 — Surrogate Endpoint (SUR): Blood pressure
Study 31047819 — Predictive Biomarker (PRD): HAL mRNA
Genes: HAL; HIS
Study 25723140 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15202047 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 26892413 — Predictive Biomarker (PRD): IK mRNA
Genes: IK; RED; RER
Study 17400977 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17400977 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17400977 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 17400977 — Safety Biomarker (SAF): IL-6 and IL-10
Study 30619887 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 10391070 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 10391070 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20104935 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17604563 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7999408 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 31040088 — Surrogate Endpoint (SUR): Blood pressure
Study 22250032 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 22250032 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24993458 — Surrogate Endpoint (SUR): Blood pressure
Study 24993458 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28860019 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 28860019 — Surrogate Endpoint (SUR): Blood pressure
Study 17409767 — Surrogate Endpoint (SUR): Blood pressure
Study 17409767 — Surrogate Endpoint (SUR): Serum calcium
Study 21502567 — Surrogate Endpoint (SUR): Blood pressure
Study 18931204 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 18931204 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 18931204 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 18931204 — Surrogate Endpoint (SUR): Serum creatinine
Study 12826159 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 7067470 — Surrogate Endpoint (SUR): Blood pressure
Study 7067470 — Surrogate Endpoint (SUR): Serum potassium
Study 24569459 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 24569459 — Predictive Biomarker (PRD): PHEX mRNA
Genes: PHEX; PEX
Study 25831464 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25831464 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 21094951 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 14985229 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 14985229 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 19398603 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 3501274 — Monitoring Biomarker (MOI): HBV DNA
Study 8607936 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 28137517 — Surrogate Endpoint (SUR): Blood pressure
Study 7595182 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 7595182 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 7595182 — Predictive Biomarker (PRD): PLTP mRNA
Genes: PLTP
Study 7595182 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 11517739 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11517739 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30980923 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 30980923 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 30980923 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 30980923 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30980923 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 30980923 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 30980923 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30980923 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28784273 — Surrogate Endpoint (SUR): Blood pressure
Study 26506070 — Surrogate Endpoint (SUR): Bone mineral density
Study 17517761 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 15489585 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 9661803 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9661803 — Safety Biomarker (SAF): Urinary microalbumin
Study 9661803 — Surrogate Endpoint (SUR): Serum creatinine
Study 15698513 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 15698513 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 10155331 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 21335482 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 21335482 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 19297346 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19297346 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10201667 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 30568294 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 19526751 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 19526751 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31463925 — Surrogate Endpoint (SUR): Blood pressure
Study 20623311 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 8762198 — Surrogate Endpoint (SUR): Blood pressure
Study 24509120 — Surrogate Endpoint (SUR): Blood pressure
Study 20421332 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 16339703 — Predictive Biomarker (PRD): Liver iron
Study 10494182 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 7081091 — Surrogate Endpoint (SUR): Serum triglycerides
Study 7081091 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31923762 — Predictive Biomarker (PRD): TNFRSF10B mRNA
Genes: TNFRSF10B; DR5; KILLER; TRAILR2; TRICK2; ZTNFR9; UNQ160/PRO186
Study 31923762 — Predictive Biomarker (PRD): TNFSF10 mRNA
Genes: TNFSF10; APO2L; TRAIL
Study 31923762 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 31923762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31923762 — Safety Biomarker (SAF): Reactive oxygen species
Study 31923762 — Safety Biomarker (SAF): c-Jun N-terminal kinase
Study 28118280 — Surrogate Endpoint (SUR): Blood pressure
Study 21380544 — Predictive Biomarker (PRD): HFE mRNA
Genes: HFE; HLAH
Study 17159079 — Surrogate Endpoint (SUR): Blood pressure
Study 8524717 — Surrogate Endpoint (SUR): Blood pressure
Study 28665534 — Predictive Biomarker (PRD): AHR mRNA
Genes: AHR; BHLHE76
Study 19752552 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 7661882 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 20200310 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 20200310 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 2324538 — Surrogate Endpoint (SUR): Hemagglutination inhibition antibody
Study 6156074 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 30962095 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 18985460 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18985460 — Safety Biomarker (SAF): IL-6 and IL-10
Study 17581601 — Surrogate Endpoint (SUR): Blood pressure
Study 16281501 — Predictive Biomarker (PRD): TERT mRNA
Genes: TERT; EST2; TCS1; TRT
Study 16281501 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 16281501 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12487225 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 9915661 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9915661 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 2744295 — Surrogate Endpoint (SUR): Blood pressure
Study 27124606 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27124606 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24067431 — Surrogate Endpoint (SUR): Blood pressure
Study 24067431 — Surrogate Endpoint (SUR): Serum creatinine
Study 2225476 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 29792288 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 29792288 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 10585309 — Surrogate Endpoint (SUR): Serum creatinine
Study 9592319 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 31343402 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24215017 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 30817999 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 30817999 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 28938963 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 19486651 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11314884 — Surrogate Endpoint (SUR): Probing pocket depth
Study 9041216 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 9041216 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 28093573 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28093573 — Monitoring Biomarker (MOI): Urokinase plasminogen activator surface receptor
Genes: PLAUR; MO3; UPAR
Study 1556523 — Surrogate Endpoint (SUR): Blood pressure
Study 26865592 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26865592 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 26865592 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 17441415 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 12523682 — Surrogate Endpoint (SUR): Blood pressure
Study 31822157 — Predictive Biomarker (PRD): ABCD2 mRNA
Genes: ABCD2; ALD1; ALDL1; ALDR; ALDRP
Study 30477629 — Pharmacodynamic Biomarker (PDY): Histone acetylation
Study 27788931 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 23766359 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 23766359 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF