TrialPanorama/TrialPanorama-database huggingface dataset:
Study 16960162 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15175800 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 7945491 — Predictive Biomarker (PRD): CYCS mRNA
Genes: CYCS; CYC
Study 7945491 — Surrogate Endpoint (SUR): Forced vital capacity
Study 3556129 — Surrogate Endpoint (SUR): Blood pressure
Study 30241488 — Surrogate Endpoint (SUR): Blood pressure
Study 23643522 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23643522 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21336433 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30724455 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25943466 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25943466 — Surrogate Endpoint (SUR): Blood pressure
Study 17729055 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 17729055 — Surrogate Endpoint (SUR): Blood pressure
Study 30285891 — Predictive Biomarker (PRD): ID1 mRNA
Genes: ID1; BHLHB24; ID
Study 22440275 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 22440275 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12890761 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 12890761 — Safety Biomarker (SAF): BDNF
Study 9004107 — Surrogate Endpoint (SUR): Blood pressure
Study 6863470 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6863470 — Surrogate Endpoint (SUR): Blood pressure
Study 2357865 — Surrogate Endpoint (SUR): Blood pressure
Study 6274571 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 8664019 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 1799889 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6365208 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 28114735 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 28114735 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 23052228 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 23052228 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 20497640 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 16422223 — Predictive Biomarker (PRD): DCT mRNA
Genes: DCT; TYRP2
Study 8905424 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 8905424 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 3574641 — Surrogate Endpoint (SUR): Blood pressure
Study 28616919 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26438161 — Safety Biomarker (SAF): Interleukin 1
Study 26438161 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26438161 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19555315 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 376572 — Surrogate Endpoint (SUR): Forced vital capacity
Study 28593413 — Surrogate Endpoint (SUR): Serum creatinine
Study 28593413 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 28593413 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28593413 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 24261187 — Surrogate Endpoint (SUR): Blood pressure
Study 14555796 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 10171162 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 6835893 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 22973092 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 1354086 — Surrogate Endpoint (SUR): Blood pressure
Study 27412415 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27412415 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24672331 — Surrogate Endpoint (SUR): Serum uric acid
Study 24672331 — Surrogate Endpoint (SUR): Serum creatinine
Study 20117105 — Predictive Biomarker (PRD): ARC mRNA
Genes: ARC; KIAA0278
Study 10423311 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 2164528 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25636072 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18469148 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 16950434 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 11053939 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11053939 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7903976 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2498620 — Surrogate Endpoint (SUR): Blood pressure
Study 28817063 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28817063 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29654643 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 15253170 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 9825366 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2114627 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 113143 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 31229376 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23470915 — Predictive Biomarker (PRD): HSPA1B mRNA
Genes: HSPA1B; HSP72
Study 9393272 — Surrogate Endpoint (SUR): Forced vital capacity
Study 3259337 — Surrogate Endpoint (SUR): Blood pressure
Study 28453780 — Predictive Biomarker (PRD): HNF4A mRNA
Genes: HNF4A; HNF4; NR2A1; TCF14
Study 28453780 — Predictive Biomarker (PRD): NEUROD1 mRNA
Genes: NEUROD1; BHLHA3; NEUROD
Study 8911877 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27354766 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27354766 — Surrogate Endpoint (SUR): Blood pressure
Study 28178175 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 28178175 — Surrogate Endpoint (SUR): Blood pressure
Study 19842560 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19842560 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14593127 — Surrogate Endpoint (SUR): Blood pressure
Study 30513818 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30513818 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22116310 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 11390725 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 27852236 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 20688319 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 21864865 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10359887 — Surrogate Endpoint (SUR): Bone mineral density
Study 7677297 — Predictive Biomarker (PRD): Hormone receptor
Study 2371802 — Surrogate Endpoint (SUR): Serum triglycerides
Study 2371802 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 27845858 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 25392071 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18260979 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 11449530 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 11449530 — Surrogate Endpoint (SUR): Serum potassium
Study 1839434 — Surrogate Endpoint (SUR): Blood pressure
Study 26402918 — Surrogate Endpoint (SUR): Blood pressure
Study 22311378 — Predictive Biomarker (PRD): SLC6A2 mRNA
Genes: SLC6A2; NAT1; NET1; SLC6A5
Study 2116440 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 25310120 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15608053 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8829846 — Surrogate Endpoint (SUR): Blood pressure
Study 2108751 — Surrogate Endpoint (SUR): Blood pressure
Study 19717850 — Predictive Biomarker (PRD): KLHL17 mRNA
Genes: KLHL17; AF
Study 31033867 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 9203645 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8203833 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 24237962 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 24237962 — Predictive Biomarker (PRD): FNDC5 mRNA
Genes: FNDC5; FRCP2
Study 24237962 — Predictive Biomarker (PRD): PPARGC1A mRNA
Genes: PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1
Study 24237962 — Predictive Biomarker (PRD): UCP1 mRNA
Genes: UCP1; SLC25A7; UCP
Study 30532527 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 30532527 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 30532527 — Surrogate Endpoint (SUR): Serum creatinine
Study 11448916 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 30489494 — Surrogate Endpoint (SUR): Blood pressure
Study 22069045 — Monitoring Biomarker (MOI): HBV DNA
Study 9706946 — Surrogate Endpoint (SUR): Blood pressure
Study 7888933 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7888933 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2404050 — Surrogate Endpoint (SUR): Blood pressure
Study 24343683 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 17991471 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17991471 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17991471 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 17991471 — Surrogate Endpoint (SUR): Serum creatinine
Study 17991471 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 20581690 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 18398813 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 7899404 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23063111 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11495260 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9209648 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 3296728 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 20973155 — Safety Biomarker (SAF): PPOX
Genes: HCRT; OX
Study 8676802 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8676802 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31322838 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 21138981 — Surrogate Endpoint (SUR): Serum creatinine
Study 25842934 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 18656091 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17094914 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 17094914 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 10484047 — Surrogate Endpoint (SUR): Serum creatinine
Study 10484047 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 1771395 — Surrogate Endpoint (SUR): Blood pressure
Study 31044688 — Predictive Biomarker (PRD): ELK3 mRNA
Genes: ELK3; NET; SAP2
Study 26603258 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 16084158 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8216442 — Predictive Biomarker (PRD): Zinc finger protein GLI1
Genes: GLI1; GLI
Study 26413853 — Monitoring Biomarker (MOI): HBV DNA
Study 24965573 — Predictive Biomarker (PRD): JAK1 mRNA
Genes: JAK1; JAK1A; JAK1B
Study 24965573 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 24965573 — Pharmacodynamic Biomarker (PDY): Signal transducer and activator of transcription 3
Genes: STAT3; APRF
Study 23046071 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 11933906 — Predictive Biomarker (PRD): TPH1 mRNA
Genes: TPH1; TPH; TPRH; TRPH
Study 31138281 — Surrogate Endpoint (SUR): Blood pressure
Study 28842370 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24528544 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 24907224 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 11435055 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 9526936 — Surrogate Endpoint (SUR): Blood pressure
Study 26002927 — Predictive Biomarker (PRD): CYP1A1 mRNA
Genes: CYP1A1
Study 26002927 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 26002927 — Predictive Biomarker (PRD): AHR mRNA
Genes: AHR; BHLHE76
Study 23899532 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 9673431 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9673431 — Surrogate Endpoint (SUR): Blood pressure
Study 26289557 — Surrogate Endpoint (SUR): Serum creatinine
Study 23282113 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MHC class I polypeptide-related sequence A
Genes: MICA; PERB11.1
Study 19515732 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19515732 — Surrogate Endpoint (SUR): Blood pressure
Study 14763921 — Predictive Biomarker (PRD): CXCR5 mRNA
Genes: CXCR5; BLR1; MDR15
Study 14763921 — Predictive Biomarker (PRD): CXCL13 mRNA
Genes: CXCL13; BCA1; BLC; SCYB13
Study 14763921 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11182175 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11182175 — Surrogate Endpoint (SUR): Blood pressure
Study 31883327 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 16678550 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 16678550 — Predictive Biomarker (PRD): CYP2E1 mRNA
Genes: CYP2E1; CYP2E
Study 8133022 — Surrogate Endpoint (SUR): Blood pressure
Study 3499896 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 3499896 — Surrogate Endpoint (SUR): Blood pressure
Study 14759562 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 14759562 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14759562 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11545752 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21682757 — Surrogate Endpoint (SUR): Bone mineral density
Study 20172051 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SOD2 mRNA
Genes: SOD2
Study 20172051 — Safety Biomarker (SAF): Reactive oxygen species
Study 13678769 — Surrogate Endpoint (SUR): Bone mineral density
Study 8686822 — Surrogate Endpoint (SUR): Blood pressure
Study 1425158 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1425158 — Surrogate Endpoint (SUR): Blood pressure
Study 27986129 — Surrogate Endpoint (SUR): Serum creatinine
Study 24942592 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 24942592 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24942592 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 14510994 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 11127439 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6476072 — Predictive Biomarker (PRD): ENG mRNA
Genes: ENG; END
Study 30842083 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 30842083 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 27918718 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 27918718 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 1333637 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 6368776 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 6368776 — Surrogate Endpoint (SUR): Serum triglycerides
Study 28742409 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28742409 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21701796 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 16158737 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 1948658 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 1948658 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 23666976 — Predictive Biomarker (PRD): TEF mRNA
Genes: TEF; KIAA1655
Study 9764864 — Surrogate Endpoint (SUR): Blood pressure
Study 2526341 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 2526341 — Surrogate Endpoint (SUR): Blood pressure
Study 19103729 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 19103729 — Safety Biomarker (SAF): Cyclin-dependent kinase inhibitor 1
Genes: CDKN1A
Study 19103729 — Predictive Biomarker (PRD): CDKN1A mRNA
Genes: CDKN1A; CAP20; CDKN1; CIP1; MDA6; PIC1; SDI1; WAF1
Study 19103729 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 17016589 — Predictive Biomarker (PRD): GSTM1 mRNA
Genes: GSTM1; GST1
Study 11035447 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 11035447 — Surrogate Endpoint (SUR): Blood pressure
Study 11035447 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2430506 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 24745701 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23444750 — Surrogate Endpoint (SUR): Bone mineral density
Study 2370643 — Surrogate Endpoint (SUR): Blood pressure
Study 31991296 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 19923361 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 19923361 — Safety Biomarker (SAF): BDNF
Study 10341016 — Surrogate Endpoint (SUR): Bone mineral density
Study 25800041 — Predictive Biomarker (PRD): NPPC mRNA
Genes: NPPC; CNP2
Study 22492368 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22492368 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11815408 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 31476994 — Surrogate Endpoint (SUR): Blood pressure
Study 11477497 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11477497 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 3168766 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 23305402 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 30518693 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 22987572 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14667955 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 1666684 — Surrogate Endpoint (SUR): Blood pressure
Study 29422049 — Surrogate Endpoint (SUR): Blood pressure
Study 27998224 — Predictive Biomarker (PRD): WEE1 mRNA
Genes: WEE1
Study 27998224 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 27998224 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 27998224 — Pharmacodynamic Biomarker (PDY): Cyclin-dependent kinase 1
Genes: CDK1; CDC2; CDC28A; CDKN1; P34CDC2
Study 23363041 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 18691228 — Surrogate Endpoint (SUR): Blood pressure
Study 18691228 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16573545 — Predictive Biomarker (PRD): TRERF1 mRNA
Genes: TRERF1; BCAR2; RAPA; TREP132
Study 8268900 — Surrogate Endpoint (SUR): Blood pressure
Study 3082592 — Surrogate Endpoint (SUR): Blood pressure
Study 28929486 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28371482 — Surrogate Endpoint (SUR): Blood pressure
Study 21693655 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 3880810 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 29925515 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 29925515 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29925515 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 23241505 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 23241505 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31645648 — Predictive Biomarker (PRD): FLT3 mRNA
Genes: FLT3; CD135; FLK2; STK1
Study 23336594 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 17347063 — Surrogate Endpoint (SUR): Bone mineral density