TrialPanorama/TrialPanorama-database huggingface dataset:
Study 16911911 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11282761 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 22948945 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22948945 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12903909 — Surrogate Endpoint (SUR): Blood pressure
Study 10769855 — Surrogate Endpoint (SUR): Blood pressure
Study 9069567 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27378824 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 22055594 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 18434749 — Surrogate Endpoint (SUR): Serum calcium
Study 18434749 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 18434749 — Surrogate Endpoint (SUR): Serum intact parathyroid hormone
Study 18434749 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18434749 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17173490 — Surrogate Endpoint (SUR): Blood pressure
Study 12706405 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12706405 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11070565 — Surrogate Endpoint (SUR): Blood pressure
Study 24708832 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24708832 — Surrogate Endpoint (SUR): Bone mineral density
Study 16055524 — Surrogate Endpoint (SUR): Blood pressure
Study 12114885 — Safety Biomarker (SAF): MTHFR
Study 26295638 — Predictive Biomarker (PRD): IK mRNA
Genes: IK; RED; RER
Study 17785486 — Surrogate Endpoint (SUR): Blood pressure
Study 12297207 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12297207 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12297207 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 10995137 — Surrogate Endpoint (SUR): Blood pressure
Study 23289009 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23289009 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 21258242 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 31329991 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22486134 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21138627 — Monitoring Biomarker (MOI): HBV DNA
Study 18702961 — Surrogate Endpoint (SUR): Serum creatinine
Study 12859561 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 12859561 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 10473963 — Predictive Biomarker (PRD): RALA mRNA
Genes: RALA; RAL
Study 1932377 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1932377 — Safety Biomarker (SAF): Interleukin 1
Study 1932377 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 29895522 — Predictive Biomarker (PRD): FGR mRNA
Genes: FGR; SRC2
Study 29895522 — Surrogate Endpoint (SUR): Blood pressure
Study 16191750 — Surrogate Endpoint (SUR): Blood pressure
Study 21593577 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 24332254 — Predictive Biomarker (PRD): CCL20 mRNA
Genes: CCL20; LARC; MIP3A; SCYA20
Study 11851576 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 10209802 — Surrogate Endpoint (SUR): Bone mineral density
Study 9159420 — Surrogate Endpoint (SUR): Serum luteinizing hormone
Study 8187240 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31051259 — Surrogate Endpoint (SUR): Blood pressure
Study 26634642 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 26634642 — Predictive Biomarker (PRD): CD27 mRNA
Genes: CD27; TNFRSF7
Study 18838564 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9401251 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9401251 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 9401251 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 16810105 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16810105 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16810105 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 11061539 — Surrogate Endpoint (SUR): Blood pressure
Study 11061539 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8299405 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8299405 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29405231 — Surrogate Endpoint (SUR): Blood pressure
Study 16009103 — Surrogate Endpoint (SUR): Serum creatinine
Study 16009103 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26154086 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 26154086 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8865702 — Surrogate Endpoint (SUR): Blood pressure
Study 8865702 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 1371291 — Surrogate Endpoint (SUR): Serum testosterone
Study 27339398 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 24624390 — Surrogate Endpoint (SUR): Probing pocket depth
Study 15165934 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 15165934 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 2433081 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 2433081 — Surrogate Endpoint (SUR): Blood pressure
Study 27334415 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 27334415 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 27334415 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 27334415 — Predictive Biomarker (PRD): NR1I2 mRNA
Genes: NR1I2; PXR
Study 27334415 — Predictive Biomarker (PRD): PPP3CA mRNA
Genes: PPP3CA; CALNA; CNA
Study 27334415 — Predictive Biomarker (PRD): PPP3CB mRNA
Genes: PPP3CB; CALNA2; CALNB; CNA2
Study 23416349 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10404948 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 7356683 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 30237250 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 27001444 — Surrogate Endpoint (SUR): Blood pressure
Study 20856830 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 12842524 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31563947 — Predictive Biomarker (PRD): TLR1 mRNA
Genes: TLR1; KIAA0012
Study 31563947 — Predictive Biomarker (PRD): TLR2 mRNA
Genes: TLR2; TIL4
Study 31563947 — Predictive Biomarker (PRD): TLR6 mRNA
Genes: TLR6
Study 31563947 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 31563947 — Predictive Biomarker (PRD): RORC mRNA
Genes: RORC; NR1F3; RORG; RZRG
Study 31563947 — Predictive Biomarker (PRD): TBX21 mRNA
Genes: TBX21; TBET; TBLYM
Study 31563947 — Predictive Biomarker (PRD): CXCR3 mRNA
Genes: CXCR3; GPR9
Study 31563947 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31563947 — Predictive Biomarker (PRD): CASP1 mRNA
Genes: CASP1; IL1BC; IL1BCE
Study 26882921 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22795099 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18806043 — Surrogate Endpoint (SUR): Blood pressure
Study 10411851 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28286249 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 18848765 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 16427852 — Safety Biomarker (SAF): Reactive oxygen species
Study 8222684 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8222684 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31413010 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 31413010 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25429531 — Surrogate Endpoint (SUR): Serum creatinine
Study 20951323 — Surrogate Endpoint (SUR): Blood pressure
Study 10919591 — Surrogate Endpoint (SUR): Serum creatinine
Study 27978511 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27978511 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 27881458 — Surrogate Endpoint (SUR): Bone mineral density
Study 22004765 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 19496921 — Predictive Biomarker (PRD): OAT mRNA
Genes: OAT
Study 19496921 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 16914600 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16914600 — Surrogate Endpoint (SUR): Serum testosterone
Study 16914600 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15362523 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 7943463 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 3148039 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 20800102 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 10663450 — Surrogate Endpoint (SUR): Blood pressure
Study 23118302 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 23118302 — Predictive Biomarker (PRD): APOC1 mRNA
Genes: APOC1
Study 23118302 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 23118302 — Predictive Biomarker (PRD): PLA2G7 mRNA
Genes: PLA2G7; PAFAH
Study 23118302 — Predictive Biomarker (PRD): ABCG2 mRNA
Genes: ABCG2; ABCP; BCRP; BCRP1; MXR
Study 23118302 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23087401 — Surrogate Endpoint (SUR): Blood pressure
Study 20564914 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 18460663 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 16368822 — Surrogate Endpoint (SUR): Blood pressure
Study 23873118 — Predictive Biomarker (PRD): ADRA2A mRNA
Genes: ADRA2A; ADRA2R; ADRAR
Study 15519006 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25212234 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22795340 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 22795340 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 22795340 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 20601740 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8535541 — Surrogate Endpoint (SUR): Blood pressure
Study 8535541 — Surrogate Endpoint (SUR): Serum triglycerides
Study 1966794 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 1966794 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 9485128 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 9485128 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2539714 — Surrogate Endpoint (SUR): Blood pressure
Study 778569 — Surrogate Endpoint (SUR): Blood pressure
Study 28583116 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 26037632 — Surrogate Endpoint (SUR): Blood pressure
Study 20108779 — Monitoring Biomarker (MOI): HBV DNA
Study 15283931 — Predictive Biomarker (PRD): MPL mRNA
Genes: MPL; TPOR
Study 23361105 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 11338300 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 9390107 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 30093449 — Predictive Biomarker (PRD): MYCN mRNA
Genes: MYCN; BHLHE37; NMYC
Study 24227801 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 18619772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18619772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18619772 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 8780339 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1361083 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19237002 — Surrogate Endpoint (SUR): Blood pressure
Study 19237002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2545721 — Predictive Biomarker (PRD): SSB mRNA
Genes: SSB
Study 24279904 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 24279904 — Safety Biomarker (SAF): MTHFR
Study 19108937 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17207719 — Surrogate Endpoint (SUR): Blood pressure
Study 336052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12138347 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20010459 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 28371205 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 28371205 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 28371205 — Surrogate Endpoint (SUR): Serum uric acid
Study 21344271 — Predictive Biomarker (PRD): Hypoxia-inducible factor 1-alpha
Genes: HIF1A; BHLHE78; MOP1; PASD8
Study 21344271 — Safety Biomarker (SAF): Cytochrome c
Study 19057513 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 19057513 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19057513 — Predictive Biomarker (PRD): AGTR1 mRNA
Genes: AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B
Study 20535927 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20535927 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20535927 — Safety Biomarker (SAF): Interleukin 12
Study 15574127 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15574127 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 7786833 — Surrogate Endpoint (SUR): Blood pressure
Study 12086366 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 12086366 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 30047538 — Predictive Biomarker (PRD): KCNK3 mRNA
Genes: KCNK3; TASK; TASK1
Study 18574771 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 18574771 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 10412920 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 31530556 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 22772319 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11471577 — Predictive Biomarker (PRD): SP9 mRNA
Genes: SP9
Study 8060627 — Surrogate Endpoint (SUR): Blood pressure
Study 25960104 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 15123336 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 8160983 — Surrogate Endpoint (SUR): Blood pressure
Study 3128465 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 30303980 — Predictive Biomarker (PRD): CXCR3 mRNA
Genes: CXCR3; GPR9
Study 30303980 — Predictive Biomarker (PRD): CXCR5 mRNA
Genes: CXCR5; BLR1; MDR15
Study 30303980 — Predictive Biomarker (PRD): CCR7 mRNA
Genes: CCR7; CMKBR7; EBI1; EVI1
Study 26545149 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26545149 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26253520 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 26253520 — Surrogate Endpoint (SUR): Blood pressure
Study 18563311 — Surrogate Endpoint (SUR): Blood pressure
Study 24737712 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 24737712 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24737712 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24737712 — Surrogate Endpoint (SUR): Blood pressure
Study 10589610 — Safety Biomarker (SAF): Alpha-glutathione S-transferase
Study 2239719 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31842993 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28969350 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 12572707 — Surrogate Endpoint (SUR): Blood pressure
Study 9498726 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 2131867 — Surrogate Endpoint (SUR): Blood pressure
Study 217271 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30040523 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 30040523 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 27763932 — Surrogate Endpoint (SUR): Blood pressure
Study 19923501 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 19923501 — Safety Biomarker (SAF): Alpha-glutathione S-transferase
Study 19923501 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 19923501 — Safety Biomarker (SAF): IL-6 and IL-10
Study 17574511 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2974791 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 15864235 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15864235 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15864235 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30089729 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 19
Genes: FGF19; UNQ334/PRO533
Study 30089729 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 26384407 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 1329475 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1329475 — Surrogate Endpoint (SUR): Blood pressure
Study 27520015 — Predictive Biomarker (PRD): OCA2 mRNA
Genes: OCA2; D15S12; P
Study 1336212 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 6231418 — Safety Biomarker (SAF): BCHE
Genes: E1
Study 17660728 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12200770 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7750308 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 25164908 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 25164908 — Predictive Biomarker (PRD): UIMC1 mRNA
Genes: UIMC1; RAP80; RXRIP110
Study 8051620 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16981102 — Predictive Biomarker (PRD): HGD mRNA
Genes: HGD; HGO
Study 10470326 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24820653 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 21930149 — Surrogate Endpoint (SUR): Blood pressure
Study 8536121 — Surrogate Endpoint (SUR): Blood pressure
Study 17199237 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 19619705 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 12957683 — Surrogate Endpoint (SUR): Blood pressure
Study 12957683 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 9816131 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 21910335 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18303965 — Predictive Biomarker (PRD): CNTF mRNA
Genes: CNTF
Study 12939735 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12939735 — Surrogate Endpoint (SUR): Serum triglycerides
Study 10689152 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 31392213 — Surrogate Endpoint (SUR): Blood pressure
Study 24937024 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24937024 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31376167 — Monitoring Biomarker (MOI): Matrix metalloproteinase 8
Genes: MMP8; CLG1
Study 30277655 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 29241909 — Predictive Biomarker (PRD): HBB mRNA
Genes: HBB
Study 2304407 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2304407 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 31626654 — Safety Biomarker (SAF): Cytochrome c
Study 12891225 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 10374861 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 10374861 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 2065470 — Surrogate Endpoint (SUR): Blood pressure
Study 25120110 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17213873 — Surrogate Endpoint (SUR): Blood pressure