TrialPanorama/TrialPanorama-database huggingface dataset:
Study 25851383 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 25851383 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20413454 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20413454 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18716761 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 18716761 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 10219066 — Surrogate Endpoint (SUR): Blood pressure
Study 7484276 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 7484276 — Surrogate Endpoint (SUR): Bone mineral density
Study 2298863 — Surrogate Endpoint (SUR): Serum calcium
Study 2298863 — Surrogate Endpoint (SUR): Blood pressure
Study 27077673 — Predictive Biomarker (PRD): BOC mRNA
Genes: BOC; UNQ604/PRO1190
Study 27077673 — Predictive Biomarker (PRD): RALA mRNA
Genes: RALA; RAL
Study 27077673 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 22909899 — Predictive Biomarker (PRD): GAPDH mRNA
Genes: GAPDH; GAPD; CDABP0047; OK/SW-cl.12
Study 18076252 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 11854873 — Surrogate Endpoint (SUR): Blood pressure
Study 10400005 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16570894 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 16570894 — Surrogate Endpoint (SUR): Bone mineral density
Study 9510449 — Surrogate Endpoint (SUR): Bone mineral density
Study 29136336 — Predictive Biomarker (PRD): CYP2B6 mRNA
Genes: CYP2B6
Study 29136336 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 29136336 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 29136336 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 29136336 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 29136336 — Predictive Biomarker (PRD): 5HTT
Genes: SLC6A4; 5-HTT; SERT1
Study 29136336 — Predictive Biomarker (PRD): HTR2A mRNA
Genes: HTR2A; HTR2
Study 29136336 — Predictive Biomarker (PRD): HTR2C mRNA
Genes: HTR2C; HTR1C
Study 24062546 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 24062546 — Safety Biomarker (SAF): BDNF
Study 15860348 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 15860348 — Predictive Biomarker (PRD): PF4 mRNA
Genes: PF4; CXCL4; SCYB4
Study 15860348 — Safety Biomarker (SAF): BDNF
Study 12412210 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 8810809 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 29192535 — Predictive Biomarker (PRD): CBS mRNA
Genes: CBS
Study 9495396 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9495396 — Surrogate Endpoint (SUR): Blood pressure
Study 2463406 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 322547 — Surrogate Endpoint (SUR): Blood pressure
Study 24126948 — Surrogate Endpoint (SUR): Blood pressure
Study 11926625 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 19369318 — Surrogate Endpoint (SUR): Blood pressure
Study 15522252 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 9314625 — Surrogate Endpoint (SUR): Blood pressure
Study 17505923 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30520976 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30520976 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30520976 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30520976 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28177745 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 31655801 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21870106 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 21870106 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 21870106 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 21870106 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 2694203 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 11129359 — Surrogate Endpoint (SUR): Blood pressure
Study 31476159 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22389080 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22389080 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 22389080 — Safety Biomarker (SAF): Interleukin 1
Study 12453549 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11289568 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 10803803 — Safety Biomarker (SAF): L-acetylcarnitine
Study 29801061 — Predictive Biomarker (PRD): MC1R mRNA
Genes: MC1R; MSHR
Study 27590876 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 27590876 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 10841227 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10367620 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2029011 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 28965435 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 24260764 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21288804 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 9005368 — Surrogate Endpoint (SUR): Bone mineral density
Study 3893704 — Surrogate Endpoint (SUR): Blood pressure
Study 24924991 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9551029 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22788525 — Surrogate Endpoint (SUR): Serum testosterone
Study 9917047 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 9917047 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 9917047 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 20332352 — Safety Biomarker (SAF): DRD2
Study 7502281 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 2310576 — Surrogate Endpoint (SUR): Blood pressure
Study 7002568 — Surrogate Endpoint (SUR): Blood pressure
Study 30477816 — Surrogate Endpoint (SUR): Blood pressure
Study 26087958 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 26087958 — Predictive Biomarker (PRD): AIP mRNA
Genes: AIP; XAP2
Study 26087958 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26087958 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26087958 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16682725 — Predictive Biomarker (PRD): CSF3 mRNA
Genes: CSF3; C17orf33; GCSF
Study 31382028 — Surrogate Endpoint (SUR): Bone mineral density
Study 28808808 — Predictive Biomarker (PRD): CARS1 mRNA
Genes: CARS1; CARS
Study 23438101 — Surrogate Endpoint (SUR): Blood pressure
Study 23438101 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23438101 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17060116 — Surrogate Endpoint (SUR): Blood pressure
Study 27555197 — Surrogate Endpoint (SUR): Blood pressure
Study 25001159 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 22585883 — Surrogate Endpoint (SUR): Blood pressure
Study 7598089 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27323792 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 25085017 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22079554 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 22079554 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22079554 — Surrogate Endpoint (SUR): Blood pressure
Study 21171669 — Predictive Biomarker (PRD): SLC38A1 mRNA
Genes: SLC38A1; ATA1; NAT2; SAT1; SNAT1
Study 17924869 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25470694 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 22130391 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 7988310 — Surrogate Endpoint (SUR): Blood pressure
Study 22795519 — Surrogate Endpoint (SUR): Serum creatinine
Study 21275162 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15745936 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15745936 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15745936 — Surrogate Endpoint (SUR): Blood pressure
Study 9163067 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 9163067 — Predictive Biomarker (PRD): PLG mRNA
Genes: PLG
Study 9163067 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 21806767 — Surrogate Endpoint (SUR): Blood pressure
Study 11545288 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 8558934 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 1921252 — Surrogate Endpoint (SUR): Blood pressure
Study 1921252 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28137295 — Safety Biomarker (SAF): PDCD1
Genes: CD279; PD1; hSLE1; PD-1
Study 25567051 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2739575 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 2739575 — Predictive Biomarker (PRD): TEF mRNA
Genes: TEF; KIAA1655
Study 25922426 — Predictive Biomarker (PRD): MT2A mRNA
Genes: MT2A; CES1; MT2
Study 21382896 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 18027383 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 3758142 — Surrogate Endpoint (SUR): Blood pressure
Study 31756281 — Predictive Biomarker (PRD): CSF1R mRNA
Genes: CSF1R; FMS
Study 31756281 — Predictive Biomarker (PRD): AWAT2 mRNA
Genes: AWAT2; DC4; DGAT2L4; MFAT; WS
Study 24732241 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24732241 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30730000 — Predictive Biomarker (PRD): GSC mRNA
Genes: GSC
Study 17925866 — Predictive Biomarker (PRD): CPE mRNA
Genes: CPE
Study 28159819 — Surrogate Endpoint (SUR): Serum creatinine
Study 23574713 — Safety Biomarker (SAF): Hyaluronic acid
Study 18222275 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 30700328 — Predictive Biomarker (PRD): FLT1 mRNA
Genes: FLT1; FLT; FRT; VEGFR1
Study 9175044 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 9175044 — Surrogate Endpoint (SUR): Serum creatinine
Study 29193677 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10323511 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 6344035 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6344035 — Surrogate Endpoint (SUR): Blood pressure
Study 30160789 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 25112087 — Surrogate Endpoint (SUR): Bone mineral density
Study 19657398 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 9869229 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 31337697 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25381051 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 21676221 — Surrogate Endpoint (SUR): Blood pressure
Study 7990904 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27067259 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 20668047 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 29092882 — Predictive Biomarker (PRD): EED mRNA
Genes: EED
Study 17483155 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 23612197 — Surrogate Endpoint (SUR): Blood pressure
Study 18850765 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 25230559 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 23773316 — Surrogate Endpoint (SUR): Blood pressure
Study 19394598 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 9437192 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 25348157 — Surrogate Endpoint (SUR): Blood pressure
Study 20033055 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 20033055 — Predictive Biomarker (PRD): KLRC1 mRNA
Genes: KLRC1; NKG2A
Study 20033055 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 20033055 — Predictive Biomarker (PRD): KLRD1 mRNA
Genes: KLRD1; CD94
Study 20033055 — Predictive Biomarker (PRD): KLRC2 mRNA
Genes: KLRC2; NKG2C
Study 6702864 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6702864 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27863065 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20395941 — Surrogate Endpoint (SUR): Blood pressure
Study 19018919 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3292598 — Surrogate Endpoint (SUR): Blood pressure
Study 18385499 — Surrogate Endpoint (SUR): Bone mineral density
Study 29951742 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 12072673 — Surrogate Endpoint (SUR): Blood pressure
Study 11792284 — Surrogate Endpoint (SUR): Blood pressure
Study 17014560 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31058534 — Predictive Biomarker (PRD): NBPF1 mRNA
Genes: NBPF1; KIAA1693
Study 31058534 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 31058534 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 24316514 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 10634196 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7081040 — Surrogate Endpoint (SUR): Blood pressure
Study 20421333 — Surrogate Endpoint (SUR): Serum testosterone
Study 18775846 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18775846 — Surrogate Endpoint (SUR): Blood pressure
Study 31714444 — Predictive Biomarker (PRD): TSPAN31 mRNA
Genes: TSPAN31; SAS
Study 31714444 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 12360157 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12360157 — Surrogate Endpoint (SUR): Blood pressure
Study 30392424 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30392424 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21162925 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 17926468 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17926468 — Surrogate Endpoint (SUR): Blood pressure
Study 28658163 — Safety Biomarker (SAF): IL-6 and IL-10
Study 22947547 — Surrogate Endpoint (SUR): Bone mineral density
Study 15342302 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15342302 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29877609 — Surrogate Endpoint (SUR): Blood pressure
Study 29877609 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24679633 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 6262206 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 6262206 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31537574 — Predictive Biomarker (PRD): CD55 mRNA
Genes: CD55; CR; DAF
Study 19166565 — Surrogate Endpoint (SUR): Blood pressure
Study 17084909 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9159562 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7958160 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 23796685 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 17947224 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31802880 — Surrogate Endpoint (SUR): Blood pressure
Study 17935545 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17935545 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11755954 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 25466655 — Surrogate Endpoint (SUR): Blood pressure
Study 25466655 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25466655 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25466655 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2987294 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30217229 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26946962 — Predictive Biomarker (PRD): PRKCB mRNA
Genes: PRKCB; PKCB; PRKCB1
Study 10451943 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 29417761 — Pharmacodynamic Biomarker (PDY): Antidrug antibody
Study 25372381 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 18393008 — Predictive Biomarker (PRD): FGR mRNA
Genes: FGR; SRC2
Study 10493680 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10493680 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 10493680 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2069776 — Surrogate Endpoint (SUR): Blood pressure
Study 31013851 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31013851 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 19325997 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 19325997 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 6983315 — Surrogate Endpoint (SUR): Blood pressure
Study 26997655 — Pharmacodynamic Biomarker (PDY): Ataxin-3
Genes: ATXN3; ATX3; MJD; MJD1; SCA3
Study 26997655 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 26997655 — Pharmacodynamic Biomarker (PDY): Histone acetylation
Study 24586256 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 2239934 — Surrogate Endpoint (SUR): Blood pressure
Study 31473505 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16555941 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 16555941 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30106637 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 27777076 — Surrogate Endpoint (SUR): Blood pressure
Study 20388201 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 30672383 — Predictive Biomarker (PRD): IGF2 mRNA
Genes: IGF2; PP1446
Study 27059887 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 27059887 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 2642754 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 2642754 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 797258 — Predictive Biomarker (PRD): ABO mRNA
Genes: ABO
Study 797258 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30137547 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22496156 — Predictive Biomarker (PRD): ABO mRNA
Genes: ABO
Study 18815438 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 25671254 — Predictive Biomarker (PRD): RET mRNA
Genes: RET; CDHF12; CDHR16; PTC; RET51
Study 25671254 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 25671254 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 10760337 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1996894 — Surrogate Endpoint (SUR): Serum creatinine
Study 27413123 — Surrogate Endpoint (SUR): Blood pressure
Study 27413123 — Surrogate Endpoint (SUR): Serum potassium
Study 17121522 — Surrogate Endpoint (SUR): Serum triglycerides
Study 12692844 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 20609187 — Surrogate Endpoint (SUR): Blood pressure
Study 10616845 — Surrogate Endpoint (SUR): Serum creatinine
Study 10616845 — Surrogate Endpoint (SUR): Serum sodium
Study 10616845 — Surrogate Endpoint (SUR): Serum potassium
Study 8830827 — Safety Biomarker (SAF): Interleukin 1
Study 30316147 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 20138267 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 12023995 — Pharmacodynamic Biomarker (PDY): Nasal potential difference
Study 18767577 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 6375603 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 31310354 — Surrogate Endpoint (SUR): Bone mineral density
Study 30028023 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 30028023 — Safety Biomarker (SAF): Aminopeptidase N
Genes: ANPEP; APN; CD13; PEPN
Study 30028023 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 10583717 — Surrogate Endpoint (SUR): Blood pressure
Study 31982847 — Surrogate Endpoint (SUR): Blood pressure
Study 30896643 — Surrogate Endpoint (SUR): Blood pressure
Study 30896643 — Safety Biomarker (SAF): Urinary microalbumin
Study 25524125 — Predictive Biomarker (PRD): TNFRSF1A mRNA
Genes: TNFRSF1A; TNFAR; TNFR1
Study 25524125 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2