TrialPanorama/TrialPanorama-database huggingface dataset:
Study 1725198 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25304723 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 25304723 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25304723 — Safety Biomarker (SAF): BDNF
Study 10210023 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 24253534 — Predictive Biomarker (PRD): DPP10 mRNA
Genes: DPP10; DPRP3; KIAA1492
Study 24253534 — Predictive Biomarker (PRD): NPSR1 mRNA
Genes: NPSR1; GPR154; GPRA; PGR14
Study 24253534 — Predictive Biomarker (PRD): ADAM33 mRNA
Genes: ADAM33; C20orf153; UNQ873/PRO1891
Study 23006968 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 12585141 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27270348 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 21624418 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 9603657 — Predictive Biomarker (PRD): ITGB2 mRNA
Genes: ITGB2; CD18; MFI7
Study 3415798 — Surrogate Endpoint (SUR): Blood pressure
Study 29242294 — Safety Biomarker (SAF): Interleukin 12
Study 23021013 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 23021013 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 8635429 — Predictive Biomarker (PRD): AMT mRNA
Genes: AMT; GCST
Study 16270403 — Monitoring Biomarker (MOI): HBV DNA
Study 76223 — Surrogate Endpoint (SUR): Serum potassium
Study 25792206 — Predictive Biomarker (PRD): AGER mRNA
Genes: AGER; RAGE
Study 8467568 — Predictive Biomarker (PRD): ATP-binding cassette sub-family C member 11
Genes: ABCC11; MRP8
Study 8467568 — Predictive Biomarker (PRD): Calgranulin B
Genes: S100A9; CAGB; CFAG; MRP14
Study 8467568 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 8467568 — Predictive Biomarker (PRD): ITGB2 mRNA
Genes: ITGB2; CD18; MFI7
Study 24214232 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 25814432 — Surrogate Endpoint (SUR): Blood pressure
Study 10421878 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 8574276 — Surrogate Endpoint (SUR): Blood pressure
Study 30244181 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 30244181 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 22274169 — Surrogate Endpoint (SUR): Blood pressure
Study 8712446 — Surrogate Endpoint (SUR): Blood pressure
Study 25947235 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 15309011 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9491017 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30339244 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 28185715 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26192975 — Surrogate Endpoint (SUR): Bone mineral density
Study 7696451 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 2821947 — Surrogate Endpoint (SUR): Blood pressure
Study 24438902 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 24438902 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 24438902 — Predictive Biomarker (PRD): CD83 mRNA
Genes: CD83
Study 24438902 — Pharmacodynamic Biomarker (PDY): T-lymphocyte activation antigen CD86
Genes: CD86; CD28LG2
Study 23519586 — Predictive Biomarker (PRD): APLNR mRNA
Genes: APLNR; AGTRL1; APJ
Study 11179104 — Surrogate Endpoint (SUR): Blood pressure
Study 29438200 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 29438200 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 21429222 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 14581425 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 14581425 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 14581425 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 8695025 — Surrogate Endpoint (SUR): Blood pressure
Study 22529513 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 31843964 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31843964 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17944585 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 17944585 — Surrogate Endpoint (SUR): Blood pressure
Study 9217822 — Predictive Biomarker (PRD): TNC mRNA
Genes: TNC; HXB
Study 9217822 — Monitoring Biomarker (MOI): Matrix metalloproteinase 1
Genes: MMP1; CLG
Study 9217822 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 26422197 — Predictive Biomarker (PRD): CDKN1B mRNA
Genes: CDKN1B; KIP1; p27
Study 22945416 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22945416 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21494604 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21494604 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 18484235 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18484235 — Safety Biomarker (SAF): Interleukin 1
Study 8348392 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 8348392 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21039930 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 17569876 — Surrogate Endpoint (SUR): Serum potassium
Study 28167849 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 25740691 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 28574605 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 7908531 — Surrogate Endpoint (SUR): Blood pressure
Study 7908531 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 27083384 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 26639027 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 15466324 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9483471 — Surrogate Endpoint (SUR): Blood pressure
Study 7509259 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 7509259 — Surrogate Endpoint (SUR): Blood pressure
Study 26354521 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 11046209 — Surrogate Endpoint (SUR): Blood pressure
Study 9504815 — Predictive Biomarker (PRD): KLHL17 mRNA
Genes: KLHL17; AF
Study 7828457 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 22415082 — Predictive Biomarker (PRD): UCP2 mRNA
Genes: UCP2; SLC25A8
Study 22415082 — Safety Biomarker (SAF): Cytochrome c
Study 15855695 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 11062382 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 21677124 — Surrogate Endpoint (SUR): Bone mineral density
Study 18826631 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 18826631 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 11252549 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9628275 — Surrogate Endpoint (SUR): Blood pressure
Study 14816 — Surrogate Endpoint (SUR): Blood pressure
Study 30814109 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 30814109 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30814109 — Safety Biomarker (SAF): miR-140
Genes: MIR140
Study 18036682 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18462734 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 11726036 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 11726036 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11726036 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 3280158 — Surrogate Endpoint (SUR): Blood pressure
Study 31839530 — Surrogate Endpoint (SUR): Forced vital capacity
Study 30973547 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30973547 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 11061603 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 24280948 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 22496161 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 22496161 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 22496161 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 22496161 — Surrogate Endpoint (SUR): Blood pressure
Study 12616982 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 12616982 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12616982 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 10518081 — Surrogate Endpoint (SUR): Blood pressure
Study 25599299 — Surrogate Endpoint (SUR): Blood pressure
Study 23700938 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16761153 — Surrogate Endpoint (SUR): Bone mineral density
Study 15486569 — Surrogate Endpoint (SUR): Blood pressure
Study 23598540 — Predictive Biomarker (PRD): FABP4 mRNA
Genes: FABP4
Study 8359959 — Surrogate Endpoint (SUR): Blood pressure
Study 16998214 — Surrogate Endpoint (SUR): Serum uric acid
Study 30636184 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16791015 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 16791015 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23122211 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 23122211 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 20371683 — Safety Biomarker (SAF): Cyclin-dependent kinase inhibitor 1
Genes: CDKN1A
Study 20371683 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 20371683 — Predictive Biomarker (PRD): Apoptosis regulator Bcl-2
Genes: BCL2
Study 20693499 — Predictive Biomarker (PRD): SPTB mRNA
Genes: SPTB; SPTB1
Study 10067800 — Surrogate Endpoint (SUR): Blood pressure
Study 1449564 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 30915660 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 30580268 — Predictive Biomarker (PRD): CPOX mRNA
Genes: CPOX; CPO; CPX
Study 12824969 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 6285318 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 16332662 — Predictive Biomarker (PRD): GSTM1 mRNA
Genes: GSTM1; GST1
Study 12417875 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25827670 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 25827670 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25827670 — Surrogate Endpoint (SUR): Serum calcium
Study 23161645 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7994805 — Surrogate Endpoint (SUR): Blood pressure
Study 28659213 — Predictive Biomarker (PRD): EBF1 mRNA
Genes: EBF1; COE1; EBF
Study 21792296 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 18055864 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 14586800 — Surrogate Endpoint (SUR): Bone mineral density
Study 10487558 — Pharmacodynamic Biomarker (PDY): Salivary secretion
Study 2265735 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 30877658 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 28760939 — Surrogate Endpoint (SUR): Blood pressure
Study 28760939 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26142514 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 26142514 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25131073 — Surrogate Endpoint (SUR): Serum creatinine
Study 15494612 — Predictive Biomarker (PRD): AKR1C1 mRNA
Genes: AKR1C1; DDH; DDH1
Study 15494612 — Predictive Biomarker (PRD): AKR1C2 mRNA
Genes: AKR1C2; DDH2
Study 15494612 — Predictive Biomarker (PRD): AKR1C3 mRNA
Genes: AKR1C3; DDH1; HSD17B5; KIAA0119; PGFS
Study 15494612 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 7621455 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 26488675 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 26488675 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 7603075 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31731609 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 15559609 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 24231627 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 20928842 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 16980115 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16980115 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8857325 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 8857325 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 27913306 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19542866 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15147545 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 7407516 — Surrogate Endpoint (SUR): Blood pressure
Study 29148144 — Surrogate Endpoint (SUR): Blood pressure
Study 2981491 — Surrogate Endpoint (SUR): Blood pressure
Study 24488143 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 17912794 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 17912794 — Predictive Biomarker (PRD): VKORC1 mRNA
Genes: VKORC1; VKOR; MSTP134; MSTP576; UNQ308/PRO351
Study 12048334 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 1623913 — Surrogate Endpoint (SUR): Blood pressure
Study 25462201 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 10903015 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30487248 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 10999778 — Surrogate Endpoint (SUR): Bone mineral density
Study 29178617 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29178617 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28391397 — Surrogate Endpoint (SUR): Bone mineral density
Study 21192237 — Predictive Biomarker (PRD): AGER mRNA
Genes: AGER; RAGE
Study 25456892 — Surrogate Endpoint (SUR): Blood pressure
Study 22882570 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 23073596 — Surrogate Endpoint (SUR): Probing pocket depth
Study 19915083 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 19915083 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19915083 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16500662 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 2215826 — Surrogate Endpoint (SUR): Serum calcium
Study 31421426 — Monitoring Biomarker (MOI): Procalcitonin
Study 31421426 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 31421426 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 12585782 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31755037 — Predictive Biomarker (PRD): HSPA8 mRNA
Genes: HSPA8; HSC70; HSP73; HSPA10
Study 31755037 — Safety Biomarker (SAF): Heat shock 70 kDa
Study 28500516 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 31145308 — Predictive Biomarker (PRD): ACE2 mRNA
Genes: ACE2; UNQ868/PRO1885
Study 31145308 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 31145308 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31145308 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31145308 — Safety Biomarker (SAF): Reactive oxygen species
Study 31145308 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 31145308 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 25331845 — Surrogate Endpoint (SUR): Blood pressure
Study 21471085 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 17418218 — Surrogate Endpoint (SUR): Blood pressure
Study 12559860 — Predictive Biomarker (PRD): IL11
Genes: IL-11; AGIF
Study 22331056 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11112238 — Surrogate Endpoint (SUR): Bone mineral density
Study 11112238 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9364981 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29777404 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 29777404 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 12701826 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 31246370 — Predictive Biomarker (PRD): FAP mRNA
Genes: FAP
Study 20666950 — Surrogate Endpoint (SUR): Serum sodium
Study 26293451 — Surrogate Endpoint (SUR): Serum creatinine
Study 11491207 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11491207 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7846219 — Surrogate Endpoint (SUR): Blood pressure
Study 30475960 — Surrogate Endpoint (SUR): Blood pressure
Study 30475960 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 28331914 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25434501 — Surrogate Endpoint (SUR): Blood pressure
Study 8836934 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 20634175 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20634175 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20634175 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17624174 — Predictive Biomarker (PRD): ARC mRNA
Genes: ARC; KIAA0278
Study 31838046 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31838046 — Predictive Biomarker (PRD): NFKBIA mRNA
Genes: NFKBIA; IKBA; MAD3; NFKBI
Study 31838046 — Safety Biomarker (SAF): Arginase-1
Genes: ARG1
Study 31838046 — Predictive Biomarker (PRD): PHACTR1 mRNA
Genes: PHACTR1; KIAA1733; RPEL1
Study 12819076 — Predictive Biomarker (PRD): CTBS mRNA
Genes: CTBS; CTB
Study 30115656 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 30172196 — Surrogate Endpoint (SUR): Blood pressure
Study 26843153 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22476807 — Safety Biomarker (SAF): Hyaluronic acid
Study 10189121 — Surrogate Endpoint (SUR): Blood pressure
Study 7750002 — Predictive Biomarker (PRD): AHR mRNA
Genes: AHR; BHLHE76
Study 26730818 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22822007 — Predictive Biomarker (PRD): NOD2 mRNA
Genes: NOD2; CARD15; IBD1
Study 20652333 — Surrogate Endpoint (SUR): Blood pressure
Study 17211705 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 11303324 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 6365501 — Surrogate Endpoint (SUR): Serum triglycerides
Study 23958540 — Predictive Biomarker (PRD): GUCY2C mRNA
Genes: GUCY2C; GUC2C; STAR
Study 10834715 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10834715 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10834715 — Safety Biomarker (SAF): IL-6 and IL-10
Study 10834715 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 23046320 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 17296571 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19574917 — Predictive Biomarker (PRD): RB1
Genes: RB; PPP1R130
Study 19016815 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12795852 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 25964375 — Surrogate Endpoint (SUR): Blood pressure
Study 23253084 — Pharmacodynamic Biomarker (PDY): Transmembrane glycoprotein NMB
Genes: GPNMB; HGFIN; NMB; UNQ1725/PRO9925
Study 23253084 — Surrogate Endpoint (SUR): Blood pressure
Study 20124885 — Surrogate Endpoint (SUR): Blood pressure
Study 16175618 — Surrogate Endpoint (SUR): Bone mineral density
Study 8610897 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 30700617 — Predictive Biomarker (PRD): NXF1 mRNA
Genes: NXF1; TAP
Study 30700617 — Predictive Biomarker (PRD): SH3BP5 mRNA
Genes: SH3BP5; SAB
Study 30700617 — Predictive Biomarker (PRD): GLS2 mRNA
Genes: GLS2; GA
Study 18509324 — Surrogate Endpoint (SUR): Serum creatinine
Study 1459169 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30577611 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 19078834 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 15950849 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 12027926 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12027926 — Surrogate Endpoint (SUR): Blood pressure
Study 28746558 — Surrogate Endpoint (SUR): Blood pressure
Study 22013800 — Monitoring Biomarker (MOI): HBV DNA