TrialPanorama/TrialPanorama-database huggingface dataset:
Study 16508385 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16508385 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 16508385 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9236446 — Surrogate Endpoint (SUR): Blood pressure
Study 3092699 — Surrogate Endpoint (SUR): Blood pressure
Study 27545351 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 24886353 — Surrogate Endpoint (SUR): Blood pressure
Study 16896732 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16896732 — Surrogate Endpoint (SUR): Blood pressure
Study 29715698 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 29715698 — Predictive Biomarker (PRD): CYP27B1 mRNA
Genes: CYP27B1; CYP1ALPHA; CYP27B
Study 15881474 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 15881474 — Surrogate Endpoint (SUR): Blood pressure
Study 1945604 — Predictive Biomarker (PRD): KY mRNA
Genes: KY
Study 6812154 — Surrogate Endpoint (SUR): Blood pressure
Study 29143550 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 28666704 — Surrogate Endpoint (SUR): Blood pressure
Study 25482680 — Safety Biomarker (SAF): Interleukin 1
Study 19723645 — Predictive Biomarker (PRD): CDKN1B mRNA
Genes: CDKN1B; KIP1; p27
Study 19723645 — Predictive Biomarker (PRD): Hormone receptor
Study 26510505 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 21940058 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 21940058 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 18327671 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 18327671 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 12800412 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28320765 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 28320765 — Surrogate Endpoint (SUR): Serum uric acid
Study 24432622 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 24432622 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 21336952 — Surrogate Endpoint (SUR): Blood pressure
Study 19121597 — Surrogate Endpoint (SUR): Bone mineral density
Study 17722822 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8523049 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 26552348 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 20359549 — Surrogate Endpoint (SUR): Blood pressure
Study 18308147 — Predictive Biomarker (PRD): Hormone receptor
Study 10626563 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 8534728 — Safety Biomarker (SAF): Aminopeptidase N
Genes: ANPEP; APN; CD13; PEPN
Study 27190374 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 20450940 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8975835 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 3070134 — Surrogate Endpoint (SUR): Blood pressure
Study 28621003 — Surrogate Endpoint (SUR): Blood pressure
Study 7824961 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 7824961 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 27287781 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27287781 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 27287781 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 27287781 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23701177 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12749493 — Predictive Biomarker (PRD): TMPRSS13 mRNA
Genes: TMPRSS13; MSP; TMPRSS11
Study 9388377 — Surrogate Endpoint (SUR): Bone mineral density
Study 9388377 — Surrogate Endpoint (SUR): Serum intact parathyroid hormone
Study 9388377 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 7945495 — Surrogate Endpoint (SUR): Serum creatinine
Study 28693601 — Surrogate Endpoint (SUR): Blood pressure
Study 23333902 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 23333902 — Predictive Biomarker (PRD): IGF2 mRNA
Genes: IGF2; PP1446
Study 23333902 — Predictive Biomarker (PRD): IGFBP1 mRNA
Genes: IGFBP1; IBP1
Study 23333902 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 18040619 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9692071 — Surrogate Endpoint (SUR): Bone mineral density
Study 8820898 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 6273020 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 25970751 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 18576295 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 6377070 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 31181536 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 29204652 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 21718484 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 10731455 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31526207 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 11166484 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30146282 — Surrogate Endpoint (SUR): Serum triglycerides
Study 30146282 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30146282 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22421169 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 31535498 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 15265256 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11413106 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 9160758 — Surrogate Endpoint (SUR): Blood pressure
Study 23782624 — Surrogate Endpoint (SUR): Blood pressure
Study 14691193 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 7981992 — Predictive Biomarker (PRD): ASPRV1 mRNA
Genes: ASPRV1; SASP
Study 2921096 — Surrogate Endpoint (SUR): Blood pressure
Study 31677046 — Surrogate Endpoint (SUR): Blood pressure
Study 31256021 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 23952999 — Surrogate Endpoint (SUR): Blood pressure
Study 9594206 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9594206 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29523267 — Surrogate Endpoint (SUR): Blood pressure
Study 27584019 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 31042621 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 28403269 — Safety Biomarker (SAF): Hyaluronic acid
Study 26063507 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 26063507 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 26063507 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26063507 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 8875537 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8875537 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 28236984 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 26812001 — Surrogate Endpoint (SUR): Blood pressure
Study 22855917 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22855917 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15867002 — Surrogate Endpoint (SUR): Sperm parameters
Study 12236630 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9808216 — Safety Biomarker (SAF): Complement factor D
Genes: CFD; DF; PFD
Study 29850922 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 19125778 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 17493152 — Predictive Biomarker (PRD): LTA mRNA
Genes: LTA; TNFB; TNFSF1
Study 17493152 — Predictive Biomarker (PRD): LGALS2 mRNA
Genes: LGALS2
Study 16198981 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Osteopontin
Genes: SPP1; BNSP; OPN; PSEC0156
Study 12421198 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 12421198 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 1952135 — Surrogate Endpoint (SUR): Blood pressure
Study 7150394 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7150394 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28551197 — Surrogate Endpoint (SUR): Serum creatinine
Study 25327828 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 23419340 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 23419340 — Surrogate Endpoint (SUR): Serum creatinine
Study 17709710 — Predictive Biomarker (PRD): GAPDH mRNA
Genes: GAPDH; GAPD; CDABP0047; OK/SW-cl.12
Study 14722031 — Predictive Biomarker (PRD): NPY mRNA
Genes: NPY
Study 3381314 — Predictive Biomarker (PRD): CPZ mRNA
Genes: CPZ
Study 24400937 — Predictive Biomarker (PRD): AAAS mRNA
Genes: AAAS; ADRACALA; GL003
Study 20837163 — Surrogate Endpoint (SUR): Blood pressure
Study 17848393 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17848393 — Surrogate Endpoint (SUR): Serum creatinine
Study 17848393 — Surrogate Endpoint (SUR): Blood pressure
Study 1369703 — Surrogate Endpoint (SUR): Blood pressure
Study 27759074 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 1 beta
Genes: IL1B; IL1F2
Study 27759074 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27759074 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27759074 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 27759074 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 23375680 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 11240235 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 28965646 — Surrogate Endpoint (SUR): Blood pressure
Study 25608582 — Surrogate Endpoint (SUR): Blood pressure
Study 18097230 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11819790 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11819790 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7947364 — Surrogate Endpoint (SUR): Blood pressure
Study 25637076 — Surrogate Endpoint (SUR): Serum calcium
Study 19643495 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 23098348 — Surrogate Endpoint (SUR): Blood pressure
Study 28735449 — Pharmacodynamic Biomarker (PDY): Signal transducer and activator of transcription 3
Genes: STAT3; APRF
Study 28735449 — Predictive Biomarker (PRD): STAT5A mRNA
Genes: STAT5A; STAT5
Study 18410547 — Predictive Biomarker (PRD): SLCO1C1 mRNA
Genes: SLCO1C1; OATP14; OATP1C1; OATPF; SLC21A14
Study 15634723 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17564561 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 17564561 — Surrogate Endpoint (SUR): Serum creatinine
Study 7840507 — Predictive Biomarker (PRD): Hormone receptor
Study 7840507 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 21844490 — Surrogate Endpoint (SUR): Blood pressure
Study 14593457 — Surrogate Endpoint (SUR): Blood pressure
Study 11403353 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 11403353 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9590488 — Surrogate Endpoint (SUR): Forced vital capacity
Study 3139428 — Surrogate Endpoint (SUR): Blood pressure
Study 27225617 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15112179 — Surrogate Endpoint (SUR): Serum calcium
Study 3884576 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 3884576 — Surrogate Endpoint (SUR): Blood pressure
Study 22112610 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 22112610 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MRP2
Genes: ABCC2; DJS; cMRP
Study 22112610 — Predictive Biomarker (PRD): ABCG2 mRNA
Genes: ABCG2; ABCP; BCRP; BCRP1; MXR
Study 17480139 — Predictive Biomarker (PRD): PAG1 mRNA
Genes: PAG1; CBP; PAG
Study 2069792 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24249309 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 24249309 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7977145 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18221329 — Predictive Biomarker (PRD): NANOS3 mRNA
Genes: NANOS3; NOS3
Study 18565251 — Safety Biomarker (SAF): Hyaluronic acid
Study 7536438 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7536438 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 7536438 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 9439530 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 9439530 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26024551 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 21097434 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1313467 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25185858 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 9660523 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9660523 — Surrogate Endpoint (SUR): Blood pressure
Study 26524801 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26524801 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 21332248 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 19836621 — Surrogate Endpoint (SUR): Blood pressure
Study 16176400 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 16176400 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 10412270 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 27528215 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 27528215 — Surrogate Endpoint (SUR): Serum phosphate
Study 27528215 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21829046 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 7988781 — Pharmacodynamic Biomarker (PDY): High-frequency oscillations
Study 47702 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 19040623 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 16546471 — Surrogate Endpoint (SUR): Bone mineral density
Study 16546471 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2876575 — Surrogate Endpoint (SUR): Blood pressure
Study 9513912 — Surrogate Endpoint (SUR): Serum creatinine
Study 23888935 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 16352692 — Surrogate Endpoint (SUR): Bone mineral density
Study 9547164 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31633603 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 29141040 — Predictive Biomarker (PRD): MTTP mRNA
Genes: MTTP; MTP
Study 9397397 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 9397397 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 27084093 — Surrogate Endpoint (SUR): Blood pressure
Study 22453568 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 22453568 — Predictive Biomarker (PRD): PDGFRA mRNA
Genes: PDGFRA; PDGFR2; RHEPDGFRA
Study 11701727 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 11701727 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 11701727 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 28731780 — Surrogate Endpoint (SUR): Probing pocket depth
Study 26413749 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 19726350 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 19726350 — Surrogate Endpoint (SUR): Blood pressure
Study 17474559 — Surrogate Endpoint (SUR): Blood pressure
Study 15911473 — Surrogate Endpoint (SUR): Blood pressure
Study 10367023 — Surrogate Endpoint (SUR): Bone mineral density
Study 7018165 — Surrogate Endpoint (SUR): Blood pressure
Study 17448376 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15334509 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 8086868 — Surrogate Endpoint (SUR): Blood pressure
Study 25526229 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 8778554 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8778554 — Predictive Biomarker (PRD): IK mRNA
Genes: IK; RED; RER
Study 8778554 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 31813866 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24163120 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24163120 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15276659 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 10720128 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 8965154 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 31280997 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 31280997 — Surrogate Endpoint (SUR): Serum creatinine
Study 19549094 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 8737620 — Surrogate Endpoint (SUR): Bone mineral density
Study 8737620 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 1591369 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 26187183 — Surrogate Endpoint (SUR): Blood pressure
Study 24172699 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21645507 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21645507 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15232804 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9517609 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 3191663 — Surrogate Endpoint (SUR): Serum potassium
Study 22957013 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 19440168 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 22868247 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 22868247 — Surrogate Endpoint (SUR): Serum testosterone
Study 21209062 — Surrogate Endpoint (SUR): Blood pressure
Study 31258919 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21498100 — Predictive Biomarker (PRD): COL1A1 mRNA
Genes: COL1A1
Study 21498100 — Predictive Biomarker (PRD): COL3A1 mRNA
Genes: COL3A1
Study 16344317 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 10858919 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 11273147 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2455152 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2455152 — Surrogate Endpoint (SUR): Blood pressure
Study 24682206 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 22075170 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 16189252 — Surrogate Endpoint (SUR): Bone mineral density
Study 8666320 — Monitoring Biomarker (MOI): HBV DNA
Study 23038102 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23038102 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 20437076 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7605984 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 22991267 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 21788629 — Surrogate Endpoint (SUR): Blood pressure
Study 14515062 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14515062 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12118746 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12118746 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 12118746 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 12118746 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 31238304 — Surrogate Endpoint (SUR): Blood pressure
Study 20813884 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1