TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23166203 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18836622 — Surrogate Endpoint (SUR): Blood pressure
Study 12544441 — Surrogate Endpoint (SUR): Blood pressure
Study 12544441 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 12544441 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 12544441 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22925498 — Safety Biomarker (SAF): Hyaluronic acid
Study 21107600 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 30209589 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 30209589 — Predictive Biomarker (PRD): CCL21 mRNA
Genes: CCL21; SCYA21; UNQ784/PRO1600
Study 30499221 — Predictive Biomarker (PRD): MYRF mRNA
Genes: MYRF; C11orf9; KIAA0954; MRF
Study 25547786 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 20135347 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 20135347 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 20135347 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 20135347 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 20135347 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20135347 — Predictive Biomarker (PRD); Safety Biomarker (SAF): EGFR
Genes: ERBB1; ERRP
Study 12207812 — Surrogate Endpoint (SUR): Blood pressure
Study 8942326 — Surrogate Endpoint (SUR): Forced vital capacity
Study 1680982 — Surrogate Endpoint (SUR): Serum creatinine
Study 28183355 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Trefoil factor 3
Genes: TFF3; ITF; TFI
Study 12297482 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12297482 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 1710099 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 30487231 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 19481229 — Surrogate Endpoint (SUR): Serum creatinine
Study 31860534 — Predictive Biomarker (PRD): CIT mRNA
Genes: CIT; CRIK; KIAA0949; STK21
Study 30971596 — Surrogate Endpoint (SUR): Blood pressure
Study 9245870 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9245870 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8506518 — Surrogate Endpoint (SUR): Serum calcium
Study 27406347 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 12814458 — Predictive Biomarker (PRD): ABCC8 mRNA
Genes: ABCC8; HRINS; SUR; SUR1
Study 12814458 — Predictive Biomarker (PRD): ABCC9 mRNA
Genes: ABCC9; SUR2
Study 10812323 — Surrogate Endpoint (SUR): Blood pressure
Study 10812323 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8859194 — Surrogate Endpoint (SUR): Serum calcium
Study 1495798 — Safety Biomarker (SAF): Hyaluronic acid
Study 30012188 — Surrogate Endpoint (SUR): Blood pressure
Study 22248752 — Surrogate Endpoint (SUR): Blood pressure
Study 16304304 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10220203 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 10220203 — Surrogate Endpoint (SUR): Blood pressure
Study 23516412 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23516412 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 21288278 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2449013 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 12900684 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8449257 — Surrogate Endpoint (SUR): Blood pressure
Study 3761107 — Surrogate Endpoint (SUR): Serum calcium
Study 30416909 — Predictive Biomarker (PRD): LEP mRNA
Genes: LEP; OB; OBS
Study 15667387 — Surrogate Endpoint (SUR): Blood pressure
Study 10622478 — Predictive Biomarker (PRD): TMPRSS13 mRNA
Genes: TMPRSS13; MSP; TMPRSS11
Study 10622478 — Predictive Biomarker (PRD): THBS1 mRNA
Genes: THBS1; TSP; TSP1
Study 25380743 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25380743 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 25380743 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11126205 — Surrogate Endpoint (SUR): Serum potassium
Study 3887500 — Surrogate Endpoint (SUR): Blood pressure
Study 22160847 — Surrogate Endpoint (SUR): Blood pressure
Study 27710241 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 24423356 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 24423356 — Surrogate Endpoint (SUR): Bone mineral density
Study 15647042 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 8901851 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 6643397 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 21949007 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18685141 — Surrogate Endpoint (SUR): Blood pressure
Study 18685141 — Surrogate Endpoint (SUR): Serum triglycerides
Study 15364796 — Surrogate Endpoint (SUR): Serum creatinine
Study 9531327 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 8075874 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 2583158 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 31682542 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 26485914 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 21487312 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31547939 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 31547939 — Safety Biomarker (SAF): Uromodulin
Genes: UMOD
Study 30615068 — Surrogate Endpoint (SUR): Bone mineral density
Study 26026350 — Predictive Biomarker (PRD): MNT mRNA
Genes: MNT; BHLHD3; ROX
Study 22939006 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 11827684 — Surrogate Endpoint (SUR): Blood pressure
Study 9881390 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9881390 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25252480 — Surrogate Endpoint (SUR): Serum calcium
Study 20558553 — Predictive Biomarker (PRD): PTPRF mRNA
Genes: PTPRF; LAR
Study 28809743 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 18435868 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 8684767 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 25492830 — Surrogate Endpoint (SUR): Blood pressure
Study 18400281 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 12867355 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 12867355 — Surrogate Endpoint (SUR): Blood pressure
Study 24969964 — Surrogate Endpoint (SUR): Blood pressure
Study 16216719 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16216719 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12456232 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12456232 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8650942 — Safety Biomarker (SAF): 51Cr-EDTA
Study 1435170 — Surrogate Endpoint (SUR): Bone mineral density
Study 30433809 — Surrogate Endpoint (SUR): Blood pressure
Study 18280811 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 12937238 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 9333701 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9333701 — Safety Biomarker (SAF): Interleukin 1
Study 8061845 — Surrogate Endpoint (SUR): Blood pressure
Study 7485207 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7485207 — Surrogate Endpoint (SUR): Blood pressure
Study 30092651 — Predictive Biomarker (PRD): VASP mRNA
Genes: VASP
Study 24378766 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24378766 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24378766 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16200918 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 7736318 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 20429673 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 10830013 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HLA-A
Study 27429803 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27429803 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27429803 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27429803 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 27429803 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 11916233 — Predictive Biomarker (PRD); Safety Biomarker (SAF): STAR mRNA
Genes: STAR; STARD1
Study 9723150 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 2508583 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 2508583 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1462974 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2982387 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 24642719 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24642719 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12775025 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 22726105 — Monitoring Biomarker (MOI): HBV DNA
Study 12538460 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 12538460 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 12538460 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 28939746 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 28939746 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 17341128 — Predictive Biomarker (PRD): PPARGC1A mRNA
Genes: PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1
Study 17341128 — Predictive Biomarker (PRD): TFAM mRNA
Genes: TFAM; TCF6; TCF6L2
Study 17341128 — Predictive Biomarker (PRD): PARL mRNA
Genes: PARL; PSARL; PRO2207
Study 17341128 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Mitochondrial DNA
Study 3316309 — Surrogate Endpoint (SUR): Blood pressure
Study 3316309 — Surrogate Endpoint (SUR): Serum potassium
Study 22387529 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9877445 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 21757655 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 21757655 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15574110 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 11800414 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11800414 — Surrogate Endpoint (SUR): Serum creatinine
Study 16947627 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16947627 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 29846530 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 3282463 — Surrogate Endpoint (SUR): Serum calcium
Study 3282463 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 3282463 — Surrogate Endpoint (SUR): Serum creatinine
Study 28929258 — Predictive Biomarker (PRD): NPY mRNA
Genes: NPY
Study 28929258 — Predictive Biomarker (PRD): POMC mRNA
Genes: POMC
Study 26659927 — Surrogate Endpoint (SUR): Serum creatinine
Study 23586518 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9170118 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 15867584 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 15867584 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30819228 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17389558 — Predictive Biomarker (PRD): MT2A mRNA
Genes: MT2A; CES1; MT2
Study 15459602 — Surrogate Endpoint (SUR): Serum creatinine
Study 1569973 — Surrogate Endpoint (SUR): Serum creatinine
Study 27511476 — Surrogate Endpoint (SUR): Blood pressure
Study 21655990 — Predictive Biomarker (PRD): PDE3B mRNA
Genes: PDE3B
Study 21655990 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 21655990 — Predictive Biomarker (PRD): SSR3 mRNA
Genes: SSR3; TRAPG
Study 21655990 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 21655990 — Predictive Biomarker (PRD): CCDC14 mRNA
Genes: CCDC14
Study 21655990 — Predictive Biomarker (PRD): TNFRSF1A mRNA
Genes: TNFRSF1A; TNFAR; TNFR1
Study 21655990 — Safety Biomarker (SAF): Transforming growth factor beta 1
Genes: TGFB1; TGFB
Study 21655990 — Predictive Biomarker (PRD): MAP3K1
Genes: MEKK; MAPKKK1
Study 21655990 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 21655990 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 14601275 — Surrogate Endpoint (SUR): Blood pressure
Study 10854683 — Surrogate Endpoint (SUR): Blood pressure
Study 8388918 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 17209695 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 17209695 — Safety Biomarker (SAF): BDNF
Study 10341854 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 10341854 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 10341854 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10341854 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 26459421 — Surrogate Endpoint (SUR): Blood pressure
Study 20463260 — Surrogate Endpoint (SUR): Blood pressure
Study 24296715 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 20339479 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 9365356 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 6119097 — Predictive Biomarker (PRD): DBH mRNA
Genes: DBH
Study 11309635 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 8557525 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8557525 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 8557525 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 24913571 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 22386829 — Surrogate Endpoint (SUR): Blood pressure
Study 9066353 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 22500386 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 20573778 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17516992 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17516992 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 11465936 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30412905 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 16567357 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18568696 — Surrogate Endpoint (SUR): Blood pressure
Study 8834648 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 21247457 — Predictive Biomarker (PRD): ABCA1 mRNA
Genes: ABCA1; ABC1; CERP
Study 21247457 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21247457 — Surrogate Endpoint (SUR): Blood pressure
Study 28138830 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 23318497 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 23318497 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 18259012 — Predictive Biomarker (PRD): NE
Study 18259012 — Surrogate Endpoint (SUR): Blood pressure
Study 11500187 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 10197170 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 10197170 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 8119015 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 28817199 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 26225130 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 24188672 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Mucin-1
Genes: MUC1; PUM
Study 16480472 — Surrogate Endpoint (SUR): Forced vital capacity
Study 11272605 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 27502721 — Surrogate Endpoint (SUR): Serum creatinine
Study 12730085 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 31270136 — Surrogate Endpoint (SUR): Total kidney volume
Study 29567358 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15878752 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 15878752 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 2864849 — Surrogate Endpoint (SUR): Blood pressure
Study 27108476 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27108476 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24675394 — Predictive Biomarker (PRD): Hormone receptor
Study 20508941 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 20508941 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 10381807 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 8682138 — Surrogate Endpoint (SUR): Blood pressure
Study 1986659 — Surrogate Endpoint (SUR): Blood pressure
Study 19732303 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 30049309 — Surrogate Endpoint (SUR): Blood pressure
Study 19156973 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 17000947 — Surrogate Endpoint (SUR): Serum sodium
Study 17000947 — Surrogate Endpoint (SUR): Blood pressure
Study 12594136 — Surrogate Endpoint (SUR): Blood pressure
Study 9004102 — Surrogate Endpoint (SUR): Blood pressure
Study 25382404 — Predictive Biomarker (PRD): GK mRNA
Genes: GK
Study 26264543 — Predictive Biomarker (PRD): REST mRNA
Genes: REST; NRSF; XBR
Study 24478320 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 9808381 — Surrogate Endpoint (SUR): Forced vital capacity
Study 31348351 — Surrogate Endpoint (SUR): Blood pressure
Study 25367222 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 23794414 — Surrogate Endpoint (SUR): Serum sodium
Study 25585263 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25585263 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 25585263 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23294670 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23294670 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 23294670 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 23294670 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 23294670 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12921985 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 8677737 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 6691892 — Surrogate Endpoint (SUR): Blood pressure
Study 22689807 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 22689807 — Predictive Biomarker (PRD): Hormone receptor
Study 1968355 — Predictive Biomarker (PRD): ASPRV1 mRNA
Genes: ASPRV1; SASP
Study 7258124 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 31800880 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26338040 — Surrogate Endpoint (SUR): Blood pressure