TrialPanorama/TrialPanorama-database huggingface dataset:
Study 25029210 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12527974 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 26270952 — Predictive Biomarker (PRD): HFE mRNA
Genes: HFE; HLAH
Study 23568224 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 23568224 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 17972615 — Surrogate Endpoint (SUR): Blood pressure
Study 15218314 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 9758242 — Surrogate Endpoint (SUR): Blood pressure
Study 3072347 — Surrogate Endpoint (SUR): Blood pressure
Study 28619305 — Surrogate Endpoint (SUR): Blood pressure
Study 23971858 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 16715021 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 9405909 — Predictive Biomarker (PRD): NPL mRNA
Genes: NPL; C1orf13
Study 23922054 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 19608210 — Surrogate Endpoint (SUR): Blood pressure
Study 24555229 — Predictive Biomarker (PRD): IDUA mRNA
Genes: IDUA
Study 3611779 — Surrogate Endpoint (SUR): Blood pressure
Study 22416101 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 14597947 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 10523009 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 7552477 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23416015 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23416015 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23416015 — Safety Biomarker (SAF): IL-6 and IL-10
Study 23416015 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 19887957 — Surrogate Endpoint (SUR): Blood pressure
Study 18847313 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 18847313 — Pharmacodynamic Biomarker (PDY): Stromal cell-derived factor 1
Genes: CXCL12; SDF1; SDF1A; SDF1B
Study 8916958 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 26331791 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 26331791 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24296958 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22976533 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 18606913 — Surrogate Endpoint (SUR): Blood pressure
Study 17554539 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 17554539 — Predictive Biomarker (PRD): THBS1 mRNA
Genes: THBS1; TSP; TSP1
Study 17554539 — Predictive Biomarker (PRD): FLT1 mRNA
Genes: FLT1; FLT; FRT; VEGFR1
Study 17554539 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 30617588 — Surrogate Endpoint (SUR): Blood pressure
Study 11411655 — Predictive Biomarker (PRD): PARN mRNA
Genes: PARN; DAN
Study 30574865 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 17063975 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 1621545 — Safety Biomarker (SAF): BCHE
Genes: E1
Study 24225338 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24225338 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24225338 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25537177 — Surrogate Endpoint (SUR): Blood pressure
Study 18315424 — Predictive Biomarker (PRD); Safety Biomarker (SAF): FGG mRNA
Genes: FGG; PRO2061
Study 17048209 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17048209 — Surrogate Endpoint (SUR): Blood pressure
Study 30825341 — Surrogate Endpoint (SUR): Probing pocket depth
Study 18833867 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 26537365 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26537365 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26537365 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 26537365 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 1763537 — Surrogate Endpoint (SUR): Blood pressure
Study 25750345 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9666417 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 9666417 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9666417 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 9666417 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 346616 — Surrogate Endpoint (SUR): Serum uric acid
Study 23527716 — Safety Biomarker (SAF): Hyaluronic acid
Study 21484769 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 14528961 — Predictive Biomarker (PRD): DCT mRNA
Genes: DCT; TYRP2
Study 27502861 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 27502861 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16986086 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 22555773 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 12727766 — Surrogate Endpoint (SUR): Blood pressure
Study 16102546 — Predictive Biomarker (PRD): LTB4R mRNA
Genes: LTB4R; BLT; BLT1; BLTR; CMKRL1; GPR16; P2RY7
Study 11136320 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 7917935 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 21572151 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 14583577 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16670121 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 7587687 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 25282520 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 25350595 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31154006 — Predictive Biomarker (PRD): ABCG2 mRNA
Genes: ABCG2; ABCP; BCRP; BCRP1; MXR
Study 10099075 — Surrogate Endpoint (SUR): Blood pressure
Study 2233588 — Surrogate Endpoint (SUR): Blood pressure
Study 2233588 — Surrogate Endpoint (SUR): Serum potassium
Study 19720908 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 7036334 — Surrogate Endpoint (SUR): Blood pressure
Study 28063815 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26365454 — Surrogate Endpoint (SUR): Blood pressure
Study 19947275 — Surrogate Endpoint (SUR): Blood pressure
Study 28045559 — Surrogate Endpoint (SUR): Blood pressure
Study 26102252 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26102252 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 26102252 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23384733 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 19460848 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 19460848 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 16456831 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 15156439 — Surrogate Endpoint (SUR): Serum creatinine
Study 23295713 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16759045 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16759045 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16759045 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16759045 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 14715189 — Surrogate Endpoint (SUR): Blood pressure
Study 14715189 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11513913 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 8383517 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 25963380 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 25963380 — Safety Biomarker (SAF): Reactive oxygen species
Study 21654701 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21654701 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 16512787 — Surrogate Endpoint (SUR): Blood pressure
Study 1733879 — Surrogate Endpoint (SUR): Serum creatinine
Study 18987758 — Surrogate Endpoint (SUR): Serum creatinine
Study 18987758 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18987758 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 10078088 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 4361353 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 28267039 — Surrogate Endpoint (SUR): Blood pressure
Study 24727325 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 19946241 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19946241 — Safety Biomarker (SAF): IL-6 and IL-10
Study 9628277 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Mitochondrial DNA
Study 8208451 — Surrogate Endpoint (SUR): Blood pressure
Study 30739389 — Surrogate Endpoint (SUR): Blood pressure
Study 30739389 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26786187 — Surrogate Endpoint (SUR): Blood pressure
Study 26021752 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 26021752 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 26021752 — Predictive Biomarker (PRD): ERBB3 mRNA
Genes: ERBB3; HER3
Study 26021752 — Predictive Biomarker (PRD): ERBB4 mRNA
Genes: ERBB4; HER4
Study 23647408 — Predictive Biomarker (PRD): GDNF mRNA
Genes: GDNF
Study 19371942 — Surrogate Endpoint (SUR): Serum testosterone
Study 17404487 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 17404487 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 2932299 — Predictive Biomarker (PRD): SERPINA7 mRNA
Genes: SERPINA7; TBG
Study 28116765 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 28116765 — Surrogate Endpoint (SUR): Serum creatinine
Study 28116765 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 2955672 — Surrogate Endpoint (SUR): Blood pressure
Study 26614120 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 26614120 — Predictive Biomarker (PRD): ULK1 mRNA
Genes: ULK1; KIAA0722
Study 23772874 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 7540696 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 26181658 — Predictive Biomarker (PRD): JAK2 mRNA
Genes: JAK2
Study 26181658 — Surrogate Endpoint (SUR): Serum creatinine
Study 3124685 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28932907 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28932907 — Surrogate Endpoint (SUR): Blood pressure
Study 26577969 — Predictive Biomarker (PRD): CARS1 mRNA
Genes: CARS1; CARS
Study 17031505 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 17031505 — Surrogate Endpoint (SUR): Serum triglycerides
Study 30616613 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24284309 — Surrogate Endpoint (SUR): Blood pressure
Study 22763424 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22763424 — Surrogate Endpoint (SUR): Blood pressure
Study 22763424 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17703830 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 17703830 — Surrogate Endpoint (SUR): Serum calcium
Study 12399622 — Surrogate Endpoint (SUR): Blood pressure
Study 23742033 — Surrogate Endpoint (SUR): Pathological complete response
Study 10992173 — Surrogate Endpoint (SUR): Bone mineral density
Study 10992173 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27990506 — Surrogate Endpoint (SUR): Probing pocket depth
Study 24356749 — Predictive Biomarker (PRD): CDKN2A mRNA
Genes: CDKN2A; CDKN2; MTS1
Study 24356749 — Predictive Biomarker (PRD): CDKN2B mRNA
Genes: CDKN2B; MTS2
Study 20339970 — Surrogate Endpoint (SUR): Serum creatinine
Study 9275353 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 30290717 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 27593185 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 17393526 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 17393526 — Safety Biomarker (SAF): Hyaluronic acid
Study 3893208 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10096258 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 21784190 — Surrogate Endpoint (SUR): Bone mineral density
Study 19254604 — Surrogate Endpoint (SUR): Blood pressure
Study 9025127 — Surrogate Endpoint (SUR): Blood pressure
Study 10554512 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 9772588 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 9772588 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 29193247 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 18281786 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 12665986 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 12665986 — Predictive Biomarker (PRD): GAPDH mRNA
Genes: GAPDH; GAPD; CDABP0047; OK/SW-cl.12
Study 11737046 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 11737046 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9264419 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23430418 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 23430418 — Safety Biomarker (SAF): Interleukin 12
Study 23430418 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23430418 — Safety Biomarker (SAF): Interleukin 1
Study 23430418 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 18287163 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12564609 — Safety Biomarker (SAF): DRD2
Study 11236240 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 27943408 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 27943408 — Surrogate Endpoint (SUR): Bone mineral density
Study 22451196 — Predictive Biomarker (PRD); Safety Biomarker (SAF): FGA mRNA
Genes: FGA
Study 9020998 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 26420180 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21906811 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21906811 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12356389 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7124567 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 30393015 — Surrogate Endpoint (SUR): Blood pressure
Study 30393015 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 27108405 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 27108405 — Surrogate Endpoint (SUR): Bone mineral density
Study 22147202 — Surrogate Endpoint (SUR): Blood pressure
Study 12486207 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9935129 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9935129 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14624940 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8971536 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 28864036 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28864036 — Surrogate Endpoint (SUR): Blood pressure
Study 28295907 — Surrogate Endpoint (SUR): Blood pressure
Study 28295907 — Surrogate Endpoint (SUR): Serum creatinine
Study 23724913 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 29096998 — Predictive Biomarker (PRD): HTRA1 mRNA
Genes: HTRA1; HTRA; PRSS11
Study 29096998 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 29096998 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 12355332 — Surrogate Endpoint (SUR): Blood pressure
Study 30021340 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 30021340 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30021340 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7443592 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 23384404 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 11328901 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23349313 — Predictive Biomarker (PRD): GCG mRNA
Genes: GCG
Study 18528671 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 17162712 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 17162712 — Surrogate Endpoint (SUR): Bone mineral density
Study 29478819 — Surrogate Endpoint (SUR): Forced vital capacity
Study 28679554 — Surrogate Endpoint (SUR): Blood pressure
Study 16437674 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30346554 — Predictive Biomarker (PRD): OCA2 mRNA
Genes: OCA2; D15S12; P
Study 15250431 — Predictive Biomarker (PRD): PPT1 mRNA
Genes: PPT1; CLN1; PPT
Study 2764689 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2764689 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 2764689 — Predictive Biomarker (PRD): CALD1 mRNA
Genes: CALD1; CAD; CDM
Study 2764689 — Surrogate Endpoint (SUR): Blood pressure
Study 9271771 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 29669938 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 16002074 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 16002074 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 12675716 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 10774784 — Surrogate Endpoint (SUR): Blood pressure
Study 8863775 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27100101 — Predictive Biomarker (PRD): MGP mRNA
Genes: MGP; MGLAP; GIG36
Study 27100101 — Surrogate Endpoint (SUR): Serum creatinine
Study 22918156 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7549379 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 9758084 — Surrogate Endpoint (SUR): Blood pressure
Study 28957940 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28957940 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 28957940 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28957940 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 28957940 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 17538167 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 11600554 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11600554 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29668397 — Safety Biomarker (SAF): Cytochrome c
Study 28347337 — Predictive Biomarker (PRD): MMD mRNA
Genes: MMD; PAQR11
Study 8379625 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 8379625 — Predictive Biomarker (PRD): ASRGL1 mRNA
Genes: ASRGL1; ALP; CRASH
Study 3021407 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23716067 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 1388048 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 29028463 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 25418493 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25418493 — Surrogate Endpoint (SUR): Blood pressure
Study 11771598 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 11771598 — Surrogate Endpoint (SUR): Blood pressure
Study 25257871 — Predictive Biomarker (PRD): ACACB mRNA
Genes: ACACB; ACC2; ACCB
Study 25257871 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 17094978 — Predictive Biomarker (PRD): SRC mRNA
Genes: SRC; SRC1
Study 17094978 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 6529913 — Surrogate Endpoint (SUR): Blood pressure
Study 11113398 — Surrogate Endpoint (SUR): Bone mineral density
Study 21145519 — Surrogate Endpoint (SUR): Bone mineral density
Study 21876043 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 7894066 — Surrogate Endpoint (SUR): Blood pressure
Study 27704296 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27704296 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27704296 — Surrogate Endpoint (SUR): Probing pocket depth
Study 27704296 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor