TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23923010 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 11391226 — Predictive Biomarker (PRD): RRAD mRNA
Genes: RRAD; RAD
Study 8104238 — Surrogate Endpoint (SUR): Blood pressure
Study 30114973 — Predictive Biomarker (PRD): MIF mRNA
Genes: MIF; GLIF; MMIF
Study 28868876 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 28868876 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 10962113 — Surrogate Endpoint (SUR): Blood pressure
Study 3529352 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26215222 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 25400056 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 26775476 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21398582 — Predictive Biomarker (PRD): CD160 mRNA
Genes: CD160; BY55
Study 21398582 — Predictive Biomarker (PRD): CD244 mRNA
Genes: CD244; 2B4
Study 18314433 — Surrogate Endpoint (SUR): Blood pressure
Study 15864239 — Predictive Biomarker (PRD): RANGAP1 mRNA
Genes: RANGAP1; KIAA1835; SD
Study 12202662 — Safety Biomarker (SAF): Dihydrothymine dehydrogenase
Genes: DPYD
Study 10599909 — Safety Biomarker (SAF): Interleukin 1
Study 30995972 — Surrogate Endpoint (SUR): Serum creatinine
Study 25795029 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25795029 — Surrogate Endpoint (SUR): Blood pressure
Study 23173698 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 11711490 — Surrogate Endpoint (SUR): Blood pressure
Study 28746977 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 27388615 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 27388615 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18254893 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 16356539 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 16356539 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16356539 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 16356539 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 16146551 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 10218721 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10218721 — Surrogate Endpoint (SUR): Blood pressure
Study 31591187 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 31591187 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31591187 — Predictive Biomarker (PRD): AKT1 mRNA
Genes: AKT1; PKB; RAC
Study 31591187 — Predictive Biomarker (PRD): CDK4 mRNA
Genes: CDK4
Study 31591187 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 10097929 — Predictive Biomarker (PRD): NPL mRNA
Genes: NPL; C1orf13
Study 31088188 — Surrogate Endpoint (SUR): Blood pressure
Study 25050518 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25050518 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22933671 — Safety Biomarker (SAF): Hyaluronic acid
Study 19567453 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19567453 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 18604047 — Surrogate Endpoint (SUR): Blood pressure
Study 23084240 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 20737113 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 11057100 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11057100 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30628167 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 29580529 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29580529 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25109411 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 25109411 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 20485306 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7615107 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 28872938 — Surrogate Endpoint (SUR): Forced vital capacity
Study 25632742 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 22227558 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 12020988 — Surrogate Endpoint (SUR): Blood pressure
Study 10737700 — Predictive Biomarker (PRD): CORT mRNA
Genes: CORT; UNQ307/PRO350
Study 23328421 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 12854359 — Surrogate Endpoint (SUR): Blood pressure
Study 12201566 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1333518 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 12009344 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 12009344 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2454378 — Surrogate Endpoint (SUR): Blood pressure
Study 28595700 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25432220 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11148800 — Surrogate Endpoint (SUR): Bone mineral density
Study 8823827 — Predictive Biomarker (PRD): FHL5 mRNA
Genes: FHL5; ACT
Study 25480673 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25480673 — Surrogate Endpoint (SUR): Serum creatinine
Study 25480673 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 15956360 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 7537286 — Predictive Biomarker (PRD): BLM mRNA
Genes: BLM; RECQ2; RECQL3
Study 28081548 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 18433304 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 16540798 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 14575766 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 8829094 — Surrogate Endpoint (SUR): Serum calcium
Study 30646152 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31540611 — Predictive Biomarker (PRD): OAT mRNA
Genes: OAT
Study 20078213 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 21876476 — Surrogate Endpoint (SUR): Blood pressure
Study 21876476 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 9756250 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 31557450 — Surrogate Endpoint (SUR): Blood pressure
Study 28800383 — Predictive Biomarker (PRD): CTSC mRNA
Genes: CTSC; CPPI
Study 11019837 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 26820305 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 24281139 — Surrogate Endpoint (SUR): Blood pressure
Study 25150151 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 25150151 — Surrogate Endpoint (SUR): Pathological complete response
Study 12600855 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 26916657 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 18081900 — Predictive Biomarker (PRD): NFIC mRNA
Genes: NFIC; NFI
Study 29533717 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 20623992 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 20623992 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 16152826 — Predictive Biomarker (PRD): GSC mRNA
Genes: GSC
Study 16152826 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 16152826 — Surrogate Endpoint (SUR): Serum testosterone
Study 1474075 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1474075 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 21788633 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 8390288 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 29748010 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29748010 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 29748010 — Safety Biomarker (SAF): Serine/threonine-protein kinase STK11
Genes: STK11
Study 29748010 — Predictive Biomarker (PRD): PIK3CA mRNA
Genes: PIK3CA
Study 15678039 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 15198767 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 30605260 — Predictive Biomarker (PRD): SLC22A2 mRNA
Genes: SLC22A2; OCT2
Study 30605260 — Predictive Biomarker (PRD): SLC47A1 mRNA
Genes: SLC47A1; MATE1
Study 30605260 — Predictive Biomarker (PRD): SLC47A2 mRNA
Genes: SLC47A2; MATE2
Study 23484181 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 23484181 — Surrogate Endpoint (SUR): Probing pocket depth
Study 15555501 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 15555501 — Predictive Biomarker (PRD): TRAPPC9 mRNA
Genes: TRAPPC9; KIAA1882; NIBP; T1
Study 8279405 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2525470 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 27583688 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 26374703 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23426344 — Safety Biomarker (SAF): Hyaluronic acid
Study 8637514 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21105276 — Predictive Biomarker (PRD): FTO mRNA
Genes: FTO; KIAA1752
Study 21105276 — Predictive Biomarker (PRD): LEP mRNA
Genes: LEP; OB; OBS
Study 21105276 — Predictive Biomarker (PRD): LEPROT mRNA
Genes: LEPROT; LEPR; OBR
Study 11007679 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 11007679 — Surrogate Endpoint (SUR): Blood pressure
Study 8698449 — Surrogate Endpoint (SUR): Blood pressure
Study 6695841 — Surrogate Endpoint (SUR): Blood pressure
Study 25187485 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 25187485 — Predictive Biomarker (PRD): CYP2B6 mRNA
Genes: CYP2B6
Study 18397817 — Surrogate Endpoint (SUR): Blood pressure
Study 29020356 — Predictive Biomarker (PRD): LILRB5 mRNA
Genes: LILRB5; LIR8
Study 29020356 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 17476567 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 21875633 — Predictive Biomarker (PRD): SPR mRNA
Genes: SPR
Study 19289636 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 7779855 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 7779855 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31422134 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 31322086 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31322086 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23122974 — Surrogate Endpoint (SUR): Blood pressure
Study 17023237 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 11062355 — Surrogate Endpoint (SUR): Bone mineral density
Study 16758259 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 22053621 — Safety Biomarker (SAF): Reactive oxygen species
Study 1622733 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 1622733 — Predictive Biomarker (PRD): CD9 mRNA
Genes: CD9; MIC3; TSPAN29; GIG2
Study 1622733 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11929643 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 9928553 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 2692891 — Surrogate Endpoint (SUR): Blood pressure
Study 19169289 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 17482099 — Predictive Biomarker (PRD): PDXP mRNA
Genes: PDXP; CIN; PLP; PLPP
Study 17482099 — Predictive Biomarker (PRD): NLRP1 mRNA
Genes: NLRP1; CARD7; DEFCAP; KIAA0926; NAC; NALP1
Study 3323290 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 27138028 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 24144628 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 18755353 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 18755353 — Predictive Biomarker (PRD): NFKBIA
Genes: IKBA; MAD-3; IkappaBalpha
Study 18755353 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 12149235 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 12149235 — Predictive Biomarker (PRD): ABO mRNA
Genes: ABO
Study 28840637 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 19388864 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11319645 — Predictive Biomarker (PRD): UCP2 mRNA
Genes: UCP2; SLC25A8
Study 11319645 — Predictive Biomarker (PRD): UCP3 mRNA
Genes: UCP3; SLC25A9
Study 7994025 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 2898268 — Surrogate Endpoint (SUR): Blood pressure
Study 2898268 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30347431 — Pharmacodynamic Biomarker (PDY): Beta-secretase 1
Genes: BACE1; BACE; KIAA1149
Study 25794299 — Surrogate Endpoint (SUR): Blood pressure
Study 23211647 — Surrogate Endpoint (SUR): Forced vital capacity
Study 16421418 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 16421418 — Predictive Biomarker (PRD): Hormone receptor
Study 31656978 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 31656978 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 29427691 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 25712456 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 21099447 — Predictive Biomarker (PRD): CCL17 mRNA
Genes: CCL17; SCYA17; TARC
Study 21099447 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): C-X-C motif chemokine 11
Genes: CXCL11; ITAC; SCYB11; SCYB9B
Study 19672410 — Surrogate Endpoint (SUR): Blood pressure
Study 16373066 — Surrogate Endpoint (SUR): Blood pressure
Study 9120932 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 8312689 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8312689 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25083601 — Predictive Biomarker (PRD): COPE mRNA
Genes: COPE
Study 22055330 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 18380940 — Safety Biomarker (SAF): Human leucocyte antigen
Study 25374101 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 15346093 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23816755 — Surrogate Endpoint (SUR): Serum testosterone
Study 21317777 — Surrogate Endpoint (SUR): Blood pressure
Study 16179403 — Surrogate Endpoint (SUR): Blood pressure
Study 15750259 — Surrogate Endpoint (SUR): Blood pressure
Study 11308252 — Surrogate Endpoint (SUR): Bone mineral density
Study 17144515 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 10755201 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10755201 — Surrogate Endpoint (SUR): Blood pressure
Study 8689766 — Predictive Biomarker (PRD): PCLAF mRNA
Genes: PCLAF; KIAA0101; NS5ATP9; PAF; L5
Study 6588271 — Surrogate Endpoint (SUR): Plasma ammonia
Study 31338790 — Predictive Biomarker (PRD): P4HB mRNA
Genes: P4HB; ERBA2L; PDI; PDIA1; PO4DB
Study 27607571 — Surrogate Endpoint (SUR): Blood pressure
Study 25134001 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25134001 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 15665657 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 15665657 — Surrogate Endpoint (SUR): Bone mineral density
Study 21509675 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8227480 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15715614 — Surrogate Endpoint (SUR): Blood pressure
Study 11844036 — Safety Biomarker (SAF): Hyaluronic acid
Study 10414685 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 2311339 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6772808 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 6343629 — Surrogate Endpoint (SUR): Serum creatinine
Study 23173251 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23173251 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 23173251 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23173251 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 10660874 — Surrogate Endpoint (SUR): Blood pressure
Study 7558229 — Surrogate Endpoint (SUR): Serum creatinine
Study 7558229 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7558229 — Surrogate Endpoint (SUR): Blood pressure
Study 25010820 — Surrogate Endpoint (SUR): Blood pressure
Study 23016530 — Predictive Biomarker (PRD): MYRF mRNA
Genes: MYRF; C11orf9; KIAA0954; MRF
Study 3122164 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 31273577 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 22167145 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 22167145 — Predictive Biomarker (PRD): FUT1 mRNA
Genes: FUT1; H; HSC
Study 25306451 — Predictive Biomarker (PRD): GNB3 mRNA
Genes: GNB3
Study 25306451 — Predictive Biomarker (PRD): GNB3
Study 18673434 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16835424 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 16835424 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 6994782 — Surrogate Endpoint (SUR): Blood pressure
Study 25832909 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25832909 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 15215801 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21962313 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21962313 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 21962313 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21962313 — Surrogate Endpoint (SUR): Blood pressure
Study 9275424 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 9275424 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 7201809 — Surrogate Endpoint (SUR): Blood pressure
Study 27886564 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25899566 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 19095343 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 19095343 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15159225 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15159225 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9503255 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7709763 — Surrogate Endpoint (SUR): Serum calcium
Study 22129475 — Surrogate Endpoint (SUR): Blood pressure
Study 8148352 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28855239 — Predictive Biomarker (PRD): CLC mRNA
Genes: CLC; LGALS10; LGALS10A
Study 23577069 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 16513451 — Predictive Biomarker (PRD): GNB3 mRNA
Genes: GNB3
Study 16513451 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 12595969 — Surrogate Endpoint (SUR): Bone mineral density
Study 10989265 — Surrogate Endpoint (SUR): Blood pressure
Study 9069450 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3535000 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 17374661 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 11476766 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19470877 — Surrogate Endpoint (SUR): Blood pressure
Study 29190236 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 29190236 — Predictive Biomarker (PRD): CCN2 mRNA
Genes: CCN2; CTGF; HCS24; IGFBP8
Study 29190236 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 26710869 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26710869 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26710869 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 26710869 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26710869 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 16546587 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 3534850 — Surrogate Endpoint (SUR): Blood pressure
Study 23254217 — Predictive Biomarker (PRD): COPE mRNA
Genes: COPE
Study 1458892 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG