TrialPanorama/TrialPanorama-database huggingface dataset:
Study 29242937 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 29242937 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 29242937 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 25515056 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 14557432 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14557432 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 29992524 — Predictive Biomarker (PRD): NR4A1 mRNA
Genes: NR4A1; GFRP1; HMR; NAK1
Study 15855656 — Safety Biomarker (SAF): MTHFR
Study 26547399 — Predictive Biomarker (PRD): DCC mRNA
Genes: DCC; IGDCC1
Study 18436564 — Surrogate Endpoint (SUR): Serum triglycerides
Study 18436564 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18436564 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10348466 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 2157983 — Surrogate Endpoint (SUR): Forced vital capacity
Study 6368246 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 31305326 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 28918548 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 28918548 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28918548 — Predictive Biomarker (PRD): Hormone receptor
Study 22552027 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20545561 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12070197 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 8649942 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 8649942 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 37868 — Surrogate Endpoint (SUR): Blood pressure
Study 24873720 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 23037494 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 17312305 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 28367845 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 28367845 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23537071 — Predictive Biomarker (PRD): UCP2 mRNA
Genes: UCP2; SLC25A8
Study 10849265 — Monitoring Biomarker (MOI): HBV DNA
Study 30093216 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28612668 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27481077 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 16478747 — Predictive Biomarker (PRD): MDM2 mRNA
Genes: MDM2
Study 16478747 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 19720877 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19720877 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17251533 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 11743591 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8573808 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28295931 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 23537330 — Predictive Biomarker (PRD): TRAPPC9 mRNA
Genes: TRAPPC9; KIAA1882; NIBP; T1
Study 23537330 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 23537330 — Predictive Biomarker (PRD): SCN8A mRNA
Genes: SCN8A; MED
Study 23537330 — Predictive Biomarker (PRD): RRAD mRNA
Genes: RRAD; RAD
Study 15327406 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 15327406 — Surrogate Endpoint (SUR): Serum creatinine
Study 7950181 — Surrogate Endpoint (SUR): Blood pressure
Study 16167916 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 12763376 — Monitoring Biomarker (MOI): HBV DNA
Study 8843176 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 8843176 — Surrogate Endpoint (SUR): Blood pressure
Study 8843176 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 8843176 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30626611 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 30335579 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24810491 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2974715 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2974715 — Surrogate Endpoint (SUR): Blood pressure
Study 22794117 — Surrogate Endpoint (SUR): Bone mineral density
Study 22794117 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 20829713 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20829713 — Surrogate Endpoint (SUR): Blood pressure
Study 26271677 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 22474401 — Surrogate Endpoint (SUR): Blood pressure
Study 16229850 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 16229850 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 6608419 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 31951305 — Surrogate Endpoint (SUR): Blood pressure
Study 1405328 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 1405328 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 27468542 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 27468542 — Surrogate Endpoint (SUR): Blood pressure
Study 27468542 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17556425 — Surrogate Endpoint (SUR): Blood pressure
Study 16224653 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16224653 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9467547 — Surrogate Endpoint (SUR): Bone mineral density
Study 17705694 — Surrogate Endpoint (SUR): Blood pressure
Study 23218821 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 23218821 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 21777702 — Surrogate Endpoint (SUR): Blood pressure
Study 21777702 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15497363 — Predictive Biomarker (PRD): TPR mRNA
Genes: TPR
Study 2360388 — Surrogate Endpoint (SUR): Blood pressure
Study 222145 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11728761 — Surrogate Endpoint (SUR): Blood pressure
Study 9205018 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 21712498 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18279940 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 29523823 — Predictive Biomarker (PRD): TSPAN31 mRNA
Genes: TSPAN31; SAS
Study 27388012 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 24973281 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 11999456 — Surrogate Endpoint (SUR): Bone mineral density
Study 788907 — Surrogate Endpoint (SUR): Blood pressure
Study 30531382 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 30531382 — Safety Biomarker (SAF): BDNF
Study 30531382 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30531382 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30531382 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30531382 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 24013702 — Surrogate Endpoint (SUR): Blood pressure
Study 20019909 — Surrogate Endpoint (SUR): Blood pressure
Study 8061262 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 779920 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 15627814 — Predictive Biomarker (PRD): DRD4 mRNA
Genes: DRD4
Study 15627814 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10480519 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 10480519 — Predictive Biomarker (PRD): PTPRN mRNA
Genes: PTPRN; ICA3; ICA512
Study 31627905 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 28805045 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23286405 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 16286871 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 12077712 — Predictive Biomarker (PRD): TAP2 mRNA
Genes: TAP2; ABCB3; PSF2; RING11; Y1
Study 12077712 — Safety Biomarker (SAF): HLA-DQB1
Genes: IDDM1; CELIAC1
Study 12077712 — Safety Biomarker (SAF): HLA-DRB1
Genes: HLA-DR1B
Study 30015059 — Surrogate Endpoint (SUR): Blood pressure
Study 19230172 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19230172 — Safety Biomarker (SAF): ACE
Genes: ACE1; CD143
Study 19230172 — Surrogate Endpoint (SUR): Blood pressure
Study 348614 — Surrogate Endpoint (SUR): Blood pressure
Study 25289713 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 22948944 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11228485 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11228485 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7846210 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7846210 — Surrogate Endpoint (SUR): Blood pressure
Study 31642331 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 31642331 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 14624184 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 28760425 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23731375 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 20090566 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 16364710 — Surrogate Endpoint (SUR): Bone mineral density
Study 2151046 — Surrogate Endpoint (SUR): Blood pressure
Study 29380232 — Surrogate Endpoint (SUR): Blood pressure
Study 26655582 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 22253252 — Safety Biomarker (SAF): Hyaluronic acid
Study 11981352 — Predictive Biomarker (PRD): SRI mRNA
Genes: SRI
Study 28401821 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 28401821 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 20175799 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 20175799 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 27027916 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 24410738 — Surrogate Endpoint (SUR): Blood pressure
Study 7535443 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7535443 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 29329484 — Surrogate Endpoint (SUR): Bone mineral density
Study 24525954 — Surrogate Endpoint (SUR): Blood pressure
Study 19887114 — Surrogate Endpoint (SUR): Blood pressure
Study 18413220 — Surrogate Endpoint (SUR): Serum creatinine
Study 15707470 — Surrogate Endpoint (SUR): Blood pressure
Study 10639526 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 1332988 — Surrogate Endpoint (SUR): Probing pocket depth
Study 27187898 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 26458126 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 14740954 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 14740954 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 14740954 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 14740954 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): GZMB mRNA
Genes: GZMB; CGL1; CSPB; CTLA1; GRB
Study 3007250 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30420291 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 23913440 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 22773704 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22773704 — Surrogate Endpoint (SUR): Blood pressure
Study 11908555 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 28838276 — Predictive Biomarker (PRD): ZBTB7A mRNA
Genes: ZBTB7A; FBI1; LRF; ZBTB7; ZNF857A
Study 27391795 — Surrogate Endpoint (SUR): Blood pressure
Study 7560247 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30370658 — Surrogate Endpoint (SUR): Blood pressure
Study 11430394 — Surrogate Endpoint (SUR): Blood pressure
Study 14607663 — Predictive Biomarker (PRD): PCBD1 mRNA
Genes: PCBD1; DCOH; PCBD
Study 9502522 — Surrogate Endpoint (SUR): Blood pressure
Study 31218636 — Surrogate Endpoint (SUR): Blood pressure
Study 30538533 — Predictive Biomarker (PRD): LSS mRNA
Genes: LSS; OSC
Study 22863164 — Surrogate Endpoint (SUR): Blood pressure
Study 9177613 — Surrogate Endpoint (SUR): Blood pressure
Study 28093466 — Surrogate Endpoint (SUR): Blood pressure
Study 25887580 — Predictive Biomarker (PRD): STC1 mRNA
Genes: STC1; STC
Study 9661616 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 31375426 — Predictive Biomarker (PRD): HDAC9 mRNA
Genes: HDAC9; HDAC7; HDAC7B; HDRP; KIAA0744; MITR
Study 8187303 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 8187303 — Surrogate Endpoint (SUR): Bone mineral density
Study 17059437 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 17059437 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 27142044 — Predictive Biomarker (PRD): PLXNA2 mRNA
Genes: PLXNA2; KIAA0463; OCT; PLXN2; UNQ209/PRO235
Study 17852781 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 23680334 — Surrogate Endpoint (SUR): Blood pressure
Study 16540959 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16540959 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 16540959 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 24285687 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 24285687 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22966824 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19921083 — Surrogate Endpoint (SUR): Bone mineral density
Study 22364258 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-34a
Genes: MIR34A
Study 22364258 — Safety Biomarker (SAF): miR-9
Study 22364258 — Pharmacodynamic Biomarker (PDY): miR-132
Genes: MIR132
Study 22364258 — Safety Biomarker (SAF): miR-181a
Study 12182261 — Surrogate Endpoint (SUR): Blood pressure
Study 30113919 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30113919 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 30113919 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 30113919 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 24816724 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 12136612 — Predictive Biomarker (PRD): CAST mRNA
Genes: CAST
Study 2181860 — Surrogate Endpoint (SUR): Blood pressure
Study 31461138 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 30892045 — Monitoring Biomarker (MOI): Apolipoprotein A-IV
Genes: APOA4
Study 30892045 — Monitoring Biomarker (MOI): Apolipoprotein C-II
Genes: APOC2; APC2
Study 30892045 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 28731882 — Surrogate Endpoint (SUR): Bone mineral density
Study 25559798 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25559798 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 18771979 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 10202365 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 447034 — Surrogate Endpoint (SUR): Serum creatinine
Study 20650652 — Surrogate Endpoint (SUR): Blood pressure
Study 19812228 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10975586 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 10975586 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 20832963 — Predictive Biomarker (PRD): VASP mRNA
Genes: VASP
Study 28911155 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28911155 — Safety Biomarker (SAF): Interleukin 1
Study 23326188 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23326188 — Safety Biomarker (SAF): Hyaluronic acid
Study 17614029 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 16931511 — Predictive Biomarker (PRD): RAPSN mRNA
Genes: RAPSN; RNF205
Study 28911092 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 28911092 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28911092 — Predictive Biomarker (PRD): Hormone receptor
Study 20579848 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20579848 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18226768 — Surrogate Endpoint (SUR): Forced vital capacity
Study 20102347 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 20102347 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20102347 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31611264 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Neurofilament light polypeptide
Genes: NEFL; NF68; NFL
Study 25595138 — Predictive Biomarker (PRD): C-C motif chemokine 7
Genes: CCL7; MCP3; SCYA6; SCYA7
Study 25595138 — Monitoring Biomarker (MOI): C-C motif chemokine 4
Genes: CCL4; LAG1; MIP1B; SCYA4
Study 25595138 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 25595138 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 25595138 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 7587605 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 25749543 — Predictive Biomarker (PRD): DSP mRNA
Genes: DSP
Study 24535377 — Surrogate Endpoint (SUR): Blood pressure
Study 15807926 — Predictive Biomarker (PRD): Hormone receptor
Study 10447136 — Predictive Biomarker (PRD): EMB mRNA
Genes: EMB
Study 25751300 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25751300 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25751300 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 25751300 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24121698 — Surrogate Endpoint (SUR): Blood pressure
Study 17099514 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17099514 — Safety Biomarker (SAF): Cytochrome c
Study 14715354 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1802636 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 8606066 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1533606 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 1533606 — Surrogate Endpoint (SUR): Forced vital capacity
Study 16221550 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 16221550 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 25909408 — Surrogate Endpoint (SUR): Blood pressure
Study 31152308 — Safety Biomarker (SAF): Cardiac troponin T
Genes: TNNT2
Study 24589291 — Predictive Biomarker (PRD): EBP mRNA
Genes: EBP
Study 20147680 — Surrogate Endpoint (SUR): Blood pressure
Study 28817201 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21413596 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11593354 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11593354 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9520072 — Pharmacodynamic Biomarker (PDY): Amyloid beta peptide (1-40)
Genes: APP; A4; AD1
Study 9520072 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 10340280 — Surrogate Endpoint (SUR): Bone mineral density
Study 10340280 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 18563517 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18563517 — Safety Biomarker (SAF): IL-6 and IL-10
Study 15496604 — Predictive Biomarker (PRD): FN1 mRNA
Genes: FN1; FN
Study 15496604 — Surrogate Endpoint (SUR): Neutralizing antibody