TrialPanorama/TrialPanorama-database huggingface dataset:
Study 21983154 — Surrogate Endpoint (SUR): Hemagglutination inhibition antibody
Study 20482275 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12357148 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 18035192 — Surrogate Endpoint (SUR): Blood pressure
Study 12189228 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 10449886 — Predictive Biomarker (PRD): CFB mRNA
Genes: CFB; BF; BFD
Study 370586 — Surrogate Endpoint (SUR): Serum creatinine
Study 27817766 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27817766 — Surrogate Endpoint (SUR): Blood pressure
Study 11119398 — Surrogate Endpoint (SUR): Blood pressure
Study 27769282 — Surrogate Endpoint (SUR): Blood pressure
Study 16293984 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 16293984 — Predictive Biomarker (PRD): ADAMTS13 mRNA
Genes: ADAMTS13; C9orf8; UNQ6102/PRO20085
Study 8017448 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 8017448 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8017448 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26525562 — Predictive Biomarker (PRD): SAT1 mRNA
Genes: SAT1; SAT
Study 19280938 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19280938 — Safety Biomarker (SAF): Cytotoxic T-lymphocyte protein 4
Genes: CTLA4; CD152
Study 10890482 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 9351079 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30224390 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30224390 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 30224390 — Predictive Biomarker (PRD): Forkhead box protein P3
Genes: FOXP3; IPEX; JM2
Study 30224390 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 24129948 — Predictive Biomarker (PRD): SAT1 mRNA
Genes: SAT1; SAT
Study 15608430 — Surrogate Endpoint (SUR): Blood pressure
Study 15608430 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27015911 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 27015911 — Predictive Biomarker (PRD): OGG1 mRNA
Genes: OGG1; MMH; MUTM; OGH1
Study 27015911 — Predictive Biomarker (PRD): MDM2 mRNA
Genes: MDM2
Study 27015911 — Predictive Biomarker (PRD): APEX1 mRNA
Genes: APEX1; APE; APE1; APEX; APX; HAP1; REF1
Study 27015911 — Predictive Biomarker (PRD): XPC mRNA
Genes: XPC; XPCC
Study 11213068 — Surrogate Endpoint (SUR): Serum creatinine
Study 26614597 — Predictive Biomarker (PRD): FN1 mRNA
Genes: FN1; FN
Study 26614597 — Surrogate Endpoint (SUR): Bone mineral density
Study 26775516 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 20643699 — Surrogate Endpoint (SUR): Blood pressure
Study 16754836 — Predictive Biomarker (PRD): CHRNA7 mRNA
Genes: CHRNA7; NACHRA7
Study 2178941 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 2178941 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 2178941 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23193746 — Predictive Biomarker (PRD): AGA mRNA
Genes: AGA
Study 1922206 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22372774 — Surrogate Endpoint (SUR): Blood pressure
Study 17263634 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15106814 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15106814 — Surrogate Endpoint (SUR): Blood pressure
Study 9746884 — Predictive Biomarker (PRD): SPINK1 mRNA
Genes: SPINK1; PSTI
Study 9746884 — Predictive Biomarker (PRD): SLPI mRNA
Genes: SLPI; WAP4; WFDC4
Study 16420280 — Surrogate Endpoint (SUR): Blood pressure
Study 15087583 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 11168457 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11168457 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9355889 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9355889 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 25820842 — Predictive Biomarker (PRD): TRIM32 mRNA
Genes: TRIM32; HT2A
Study 19278589 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 19278589 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 15030978 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 15030978 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15030978 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11795467 — Safety Biomarker (SAF): Heat shock 70 kDa
Study 21148517 — Surrogate Endpoint (SUR): Serum creatinine
Study 16570004 — Surrogate Endpoint (SUR): Serum creatinine
Study 18312763 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18312763 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8731519 — Surrogate Endpoint (SUR): Blood pressure
Study 18664593 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16200596 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 29480202 — Predictive Biomarker (PRD): MCIDAS mRNA
Genes: MCIDAS; IDAS; MCI; MCIN
Study 18928633 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 1071665 — Surrogate Endpoint (SUR): Blood pressure
Study 26312576 — Surrogate Endpoint (SUR): Bone mineral density
Study 15257176 — Surrogate Endpoint (SUR): Blood pressure
Study 7997386 — Surrogate Endpoint (SUR): Blood pressure
Study 3348162 — Surrogate Endpoint (SUR): Blood pressure
Study 30108107 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 30108107 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 24736773 — Surrogate Endpoint (SUR): Bone mineral density
Study 15486010 — Surrogate Endpoint (SUR): Blood pressure
Study 8622045 — Predictive Biomarker (PRD): Lymphocyte activation antigen CD30
Genes: TNFRSF8; CD30; D1S166E
Study 30192638 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 30192638 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 28064380 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21135547 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 21135547 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9481597 — Surrogate Endpoint (SUR): Blood pressure
Study 15066461 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 15066461 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 15066461 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15066461 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9569566 — Surrogate Endpoint (SUR): Bone mineral density
Study 8059778 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8059778 — Surrogate Endpoint (SUR): Blood pressure
Study 8059778 — Surrogate Endpoint (SUR): Serum creatinine
Study 30817982 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 27902529 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 25931293 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 25931293 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7237920 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19922127 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 15049459 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 11493282 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 9489907 — Predictive Biomarker (PRD): NXF1 mRNA
Genes: NXF1; TAP
Study 25771294 — Surrogate Endpoint (SUR): Blood pressure
Study 18466681 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16527165 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2938923 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 31735618 — Surrogate Endpoint (SUR): Blood pressure
Study 30253968 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 27427876 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20337610 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10711744 — Surrogate Endpoint (SUR): Blood pressure
Study 25796858 — Predictive Biomarker (PRD): CDA mRNA
Genes: CDA; CDD
Study 1592541 — Surrogate Endpoint (SUR): Forced vital capacity
Study 30401001 — Safety Biomarker (SAF): MTHFR
Study 8928847 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8928847 — Surrogate Endpoint (SUR): Blood pressure
Study 27175799 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26703923 — Surrogate Endpoint (SUR): Forced vital capacity
Study 22699446 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 10049268 — Predictive Biomarker (PRD): EMB mRNA
Genes: EMB
Study 2176098 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 2176098 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 2176098 — Predictive Biomarker (PRD): SLC4A7 mRNA
Genes: SLC4A7; BT; NBC2; NBC2B; NBC3; NBCn1; SBC2; SLC4A6
Study 30580857 — Surrogate Endpoint (SUR): Serum creatinine
Study 15978969 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 22500387 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16236169 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 8563848 — Predictive Biomarker (PRD): FST mRNA
Genes: FST
Study 24415446 — Safety Biomarker (SAF): Pentraxin-related protein PTX3
Genes: PTX3; TNFAIP5; TSG14
Study 23200590 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 15342839 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 3054433 — Predictive Biomarker (PRD): HGD mRNA
Genes: HGD; HGO
Study 10227067 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 27658925 — Surrogate Endpoint (SUR): Blood pressure
Study 24717427 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22076595 — Surrogate Endpoint (SUR): Blood pressure
Study 18495964 — Safety Biomarker (SAF): Reactive oxygen species
Study 30254212 — Predictive Biomarker (PRD): SEPTIN3 mRNA
Genes: SEPTIN3; SEP3; SEPT3
Study 26409670 — Surrogate Endpoint (SUR): Blood pressure
Study 3770869 — Surrogate Endpoint (SUR): Blood pressure
Study 3770869 — Surrogate Endpoint (SUR): Serum calcium
Study 22767199 — Safety Biomarker (SAF): Hyaluronic acid
Study 21607581 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 12935406 — Predictive Biomarker (PRD): CPB1 mRNA
Genes: CPB1; CPB; PCPB
Study 8090095 — Surrogate Endpoint (SUR): Blood pressure
Study 30756274 — Predictive Biomarker (PRD): PELI1 mRNA
Genes: PELI1; PRISM
Study 8818067 — Surrogate Endpoint (SUR): Blood pressure
Study 25250780 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7589766 — Surrogate Endpoint (SUR): Blood pressure
Study 27346393 — Predictive Biomarker (PRD): SPR mRNA
Genes: SPR
Study 25861836 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 25861836 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 25861836 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 28727639 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 16206603 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12431323 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7737712 — Surrogate Endpoint (SUR): Blood pressure
Study 27807887 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24121143 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24121143 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 7575694 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7575694 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 2403063 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 29340678 — Surrogate Endpoint (SUR): Blood pressure
Study 29340678 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20438534 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20438534 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 18356633 — Surrogate Endpoint (SUR): Serum creatinine
Study 19251872 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 19251872 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18061058 — Surrogate Endpoint (SUR): Blood pressure
Study 21712261 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 22995323 — Predictive Biomarker (PRD): CXCR2 mRNA
Genes: CXCR2; IL8RB
Study 22995323 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22995323 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 11498896 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 11498896 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 8068472 — Surrogate Endpoint (SUR): Blood pressure
Study 8068472 — Surrogate Endpoint (SUR): Serum creatinine
Study 8068472 — Surrogate Endpoint (SUR): Serum potassium
Study 3181276 — Predictive Biomarker (PRD): PCLAF mRNA
Genes: PCLAF; KIAA0101; NS5ATP9; PAF; L5
Study 21174610 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 18339132 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 9365042 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 9365042 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 27183909 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 19892414 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19892414 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16198248 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12391509 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 1962805 — Surrogate Endpoint (SUR): Blood pressure
Study 17367707 — Predictive Biomarker (PRD): APOB mRNA
Genes: APOB
Study 11777296 — Surrogate Endpoint (SUR): Blood pressure
Study 11777296 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3295935 — Surrogate Endpoint (SUR): Blood pressure
Study 26745101 — Predictive Biomarker (PRD): BCAT1 mRNA
Genes: BCAT1; BCT1; ECA39
Study 26745101 — Predictive Biomarker (PRD): IKZF1 mRNA
Genes: IKZF1; IK1; IKAROS; LYF1; ZNFN1A1
Study 21668963 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 15298240 — Predictive Biomarker (PRD): PPA1 mRNA
Genes: PPA1; IOPPP; PP
Study 12959269 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 25951630 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 25951630 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25951630 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17322150 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7603218 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 2665884 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 391427 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 31994720 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 9663813 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 29241890 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 29241890 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 24231479 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19175892 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 19175892 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 3276824 — Predictive Biomarker (PRD): CYCS mRNA
Genes: CYCS; CYC
Study 31564697 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 17633358 — Surrogate Endpoint (SUR): Serum creatinine
Study 14999518 — Surrogate Endpoint (SUR): Bone mineral density
Study 26116711 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26116711 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 26116711 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 23411128 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 11069188 — Surrogate Endpoint (SUR): Bone mineral density
Study 3011891 — Surrogate Endpoint (SUR): Blood pressure
Study 3011891 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 27788510 — Surrogate Endpoint (SUR): Blood pressure
Study 24622120 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16671258 — Predictive Biomarker (PRD): MAX mRNA
Genes: MAX; BHLHD4
Study 12858075 — Predictive Biomarker (PRD): ADAMTS13 mRNA
Genes: ADAMTS13; C9orf8; UNQ6102/PRO20085
Study 12858075 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 20127419 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19100422 — Surrogate Endpoint (SUR): Bone mineral density
Study 19100422 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 11551005 — Predictive Biomarker (PRD): TPH1 mRNA
Genes: TPH1; TPH; TPRH; TRPH
Study 9763554 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 2969638 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 1385959 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1385959 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28349233 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21330912 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16400058 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 6303373 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 29496069 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 10344347 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10344347 — Surrogate Endpoint (SUR): Blood pressure
Study 6759059 — Surrogate Endpoint (SUR): Blood pressure
Study 31152039 — Predictive Biomarker (PRD): CDS1 mRNA
Genes: CDS1; CDS
Study 31152039 — Predictive Biomarker (PRD): COMMD3 mRNA
Genes: COMMD3; BUP; C10orf8
Study 21745374 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 19966527 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 19966527 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 2144941 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2144941 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23379537 — Predictive Biomarker (PRD): PTGDR2 mRNA
Genes: PTGDR2; CRTH2; DL1R; GPR44
Study 8036824 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 1256687 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 27959715 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 27959715 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26189484 — Predictive Biomarker (PRD): HAL mRNA
Genes: HAL; HIS
Study 15581649 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22456602 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 18034847 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18034847 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11991884 — Surrogate Endpoint (SUR): Forced vital capacity
Study 9505155 — Predictive Biomarker (PRD): HM13 mRNA
Genes: HM13; H13; IMP1; PSL3; SPP; MSTP086
Study 2507265 — Surrogate Endpoint (SUR): Blood pressure
Study 799563 — Surrogate Endpoint (SUR): Blood pressure
Study 28632204 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 16568143 — Predictive Biomarker (PRD): LGI1 mRNA
Genes: LGI1; EPT; UNQ775/PRO1569
Study 2869679 — Surrogate Endpoint (SUR): Blood pressure
Study 31221619 — Predictive Biomarker (PRD): Indoleamine 2,3-dioxygenase 1
Genes: IDO1; IDO; INDO
Study 28459508 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 28459508 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 24130088 — Predictive Biomarker (PRD): SMPD1 mRNA
Genes: SMPD1; ASM
Study 1656040 — Surrogate Endpoint (SUR): Blood pressure
Study 24695898 — Surrogate Endpoint (SUR): Bone mineral density
Study 15946614 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 7160549 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16375656 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 11927789 — Surrogate Endpoint (SUR): Blood pressure
Study 7649340 — Surrogate Endpoint (SUR): Blood pressure
Study 23973701 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23411958 — Pharmacodynamic Biomarker (PDY): Salivary secretion
Study 10235527 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1698137 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 31226213 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 27923158 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 27923158 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein