TrialPanorama/TrialPanorama-database huggingface dataset:
Study 16912128 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16912128 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 28000678 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 28000678 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30202872 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 29043996 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29043996 — Surrogate Endpoint (SUR): Blood pressure
Study 29043996 — Surrogate Endpoint (SUR): Serum creatinine
Study 21305484 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12057618 — Predictive Biomarker (PRD): MPL mRNA
Genes: MPL; TPOR
Study 899844 — Predictive Biomarker (PRD): CPZ mRNA
Genes: CPZ
Study 31972796 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 31781387 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 21252245 — Predictive Biomarker (PRD): GHR mRNA
Genes: GHR
Study 21252245 — Surrogate Endpoint (SUR): Bone mineral density
Study 9323798 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 31743110 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18484552 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 8743522 — Surrogate Endpoint (SUR): Blood pressure
Study 30880072 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 18035190 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18035190 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 18035190 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 15094936 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 3101709 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 19689235 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 16202499 — Predictive Biomarker (PRD): SSB mRNA
Genes: SSB
Study 10709161 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 10709161 — Surrogate Endpoint (SUR): Blood pressure
Study 3928054 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 30107381 — Safety Biomarker (SAF): IL-6 and IL-10
Study 22324943 — Surrogate Endpoint (SUR): Bone mineral density
Study 11334198 — Predictive Biomarker (PRD): FHL5 mRNA
Genes: FHL5; ACT
Study 27198187 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 24515510 — Surrogate Endpoint (SUR): Bone mineral density
Study 16266408 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 30758406 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 28577362 — Surrogate Endpoint (SUR): Serum uric acid
Study 22019891 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 22019891 — Predictive Biomarker (PRD): COG2 mRNA
Genes: COG2; LDLC
Study 22019891 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 22019891 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22019891 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26364181 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31672172 — Surrogate Endpoint (SUR): Blood pressure
Study 21361732 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 8408980 — Surrogate Endpoint (SUR): Blood pressure
Study 29114041 — Predictive Biomarker (PRD): PLA2R1 mRNA
Genes: PLA2R1; CLEC13C
Study 12802741 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27893880 — Predictive Biomarker (PRD): CA3 mRNA
Genes: CA3
Study 24267238 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 21526923 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 22739141 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 22739141 — Safety Biomarker (SAF): Glutamate dehydrogenase
Study 22739141 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-122
Genes: MIR122
Study 19846798 — Surrogate Endpoint (SUR): Blood pressure
Study 19846798 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 9001416 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 8510086 — Surrogate Endpoint (SUR): Serum potassium
Study 15665549 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11839142 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11839142 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 6650444 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6650444 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30720850 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24214140 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 29073603 — Monitoring Biomarker (MOI): Angiopoietin-1
Genes: ANGPT1; KIAA0003
Study 29073603 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 21516008 — Surrogate Endpoint (SUR): Blood pressure
Study 18068281 — Predictive Biomarker (PRD): PAFAH1B1 mRNA
Genes: PAFAH1B1; LIS1; MDCR; MDS; PAFAHA
Study 11180018 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 8264146 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 2984235 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 2984235 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 2984235 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 24219012 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24219012 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22669332 — Surrogate Endpoint (SUR): Serum triglycerides
Study 20055694 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 24043299 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24043299 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25022932 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18460563 — Predictive Biomarker (PRD): SOCS3 mRNA
Genes: SOCS3; CIS3; SSI3
Study 31902294 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 23562090 — Safety Biomarker (SAF): Interleukin 1
Study 21513812 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 21513812 — Surrogate Endpoint (SUR): Bone mineral density
Study 21513812 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21513812 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16466708 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 16466708 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 14716707 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 9868087 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 9868087 — Predictive Biomarker (PRD): ABCD1 mRNA
Genes: ABCD1; ALD
Study 2827045 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2827045 — Surrogate Endpoint (SUR): Blood pressure
Study 30216294 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16174119 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 14652498 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14652498 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 14652498 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 10962306 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 8844499 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8844499 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 8844499 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 8844499 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 10815366 — Surrogate Endpoint (SUR): Blood pressure
Study 20863381 — Surrogate Endpoint (SUR): Blood pressure
Study 10329041 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 16482098 — Predictive Biomarker (PRD): CCN2 mRNA
Genes: CCN2; CTGF; HCS24; IGFBP8
Study 8998115 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 8122598 — Surrogate Endpoint (SUR): Blood pressure
Study 2527531 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1071709 — Surrogate Endpoint (SUR): Blood pressure
Study 25457473 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 17035949 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17035949 — Surrogate Endpoint (SUR): Serum potassium
Study 11258635 — Surrogate Endpoint (SUR): Blood pressure
Study 9205627 — Surrogate Endpoint (SUR): Bone mineral density
Study 24661576 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 24661576 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 12370798 — Surrogate Endpoint (SUR): Bone mineral density
Study 10213650 — Surrogate Endpoint (SUR): Blood pressure
Study 7788948 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6111161 — Surrogate Endpoint (SUR): Blood pressure
Study 31324842 — Predictive Biomarker (PRD): ADORA2A mRNA
Genes: ADORA2A; ADORA2
Study 31324842 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 28492439 — Surrogate Endpoint (SUR): Blood pressure
Study 28492439 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15097154 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23613806 — Predictive Biomarker (PRD): SLC1A2 mRNA
Genes: SLC1A2; EAAT2; GLT1
Study 16793845 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 22607852 — Surrogate Endpoint (SUR): Blood pressure
Study 16340050 — Surrogate Endpoint (SUR): Serum triglycerides
Study 7926971 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 19948945 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 18544981 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 3524221 — Surrogate Endpoint (SUR): Serum creatinine
Study 8906519 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8906519 — Surrogate Endpoint (SUR): Blood pressure
Study 6127946 — Surrogate Endpoint (SUR): Blood pressure
Study 31628428 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 21690317 — Predictive Biomarker (PRD): CHRNA3 mRNA
Genes: CHRNA3; NACHRA3
Study 21690317 — Predictive Biomarker (PRD): CHRNA5 mRNA
Genes: CHRNA5; NACHRA5
Study 16847405 — Predictive Biomarker (PRD): HFE mRNA
Genes: HFE; HLAH
Study 12742979 — Surrogate Endpoint (SUR): Serum sodium
Study 12742979 — Surrogate Endpoint (SUR): Blood pressure
Study 12742979 — Surrogate Endpoint (SUR): Serum potassium
Study 11078176 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 11078176 — Surrogate Endpoint (SUR): Blood pressure
Study 1458788 — Surrogate Endpoint (SUR): Serum calcium
Study 29875287 — Surrogate Endpoint (SUR): Bone mineral density
Study 28245790 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9323816 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 9323816 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 27072050 — Surrogate Endpoint (SUR): Duration of severe neutropenia
Study 20520284 — Predictive Biomarker (PRD): ABCC1 mRNA
Genes: ABCC1; MRP; MRP1
Study 20520284 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 18801964 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 30926576 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 25711330 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25711330 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18611338 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18611338 — Surrogate Endpoint (SUR): Blood pressure
Study 12756159 — Safety Biomarker (SAF): IL-6 and IL-10
Study 1873936 — Surrogate Endpoint (SUR): Serum creatinine
Study 1873936 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26809842 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26809842 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25304843 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 9974404 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 7588500 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 28411872 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19335746 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 11418308 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 9554348 — Surrogate Endpoint (SUR): Serum testosterone
Study 30997917 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 28634219 — Safety Biomarker (SAF): Reactive oxygen species
Study 26648084 — Predictive Biomarker (PRD): TNFSF13B mRNA
Genes: TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; UNQ401/PRO738
Study 26648084 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 7927548 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 26249791 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26249791 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26249791 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24560487 — Surrogate Endpoint (SUR): Serum creatinine
Study 20951321 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22117718 — Predictive Biomarker (PRD): HCG22 mRNA
Genes: HCG22; G2; PBMUCL2
Study 22117718 — Predictive Biomarker (PRD): MUC22 mRNA
Genes: MUC22; G4; PBMUCL1
Study 29951552 — Safety Biomarker (SAF): Reactive oxygen species
Study 26704029 — Surrogate Endpoint (SUR): Blood pressure
Study 24149007 — Surrogate Endpoint (SUR): Blood pressure
Study 17682671 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30290289 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 30290289 — Surrogate Endpoint (SUR): Serum creatinine
Study 18289163 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 18289163 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 22007026 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20868531 — Surrogate Endpoint (SUR): Blood pressure
Study 12452760 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8557965 — Surrogate Endpoint (SUR): Blood pressure
Study 1834592 — Surrogate Endpoint (SUR): Blood pressure
Study 28272202 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28272202 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 28272202 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 28272202 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28272202 — Surrogate Endpoint (SUR): Blood pressure
Study 23429100 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 23429100 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23146135 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 12611772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1712735 — Surrogate Endpoint (SUR): Serum testosterone
Study 23872254 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 19965813 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18759293 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 18759293 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 4002807 — Surrogate Endpoint (SUR): Blood pressure
Study 21175438 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 21175438 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21175438 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16427490 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 10929903 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 31050933 — Predictive Biomarker (PRD): EDAR mRNA
Genes: EDAR; DL
Study 31050933 — Surrogate Endpoint (SUR): Probing pocket depth
Study 18444445 — Safety Biomarker (SAF): IL-6 and IL-10
Study 15363826 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 15363826 — Surrogate Endpoint (SUR): Blood pressure
Study 21438101 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 18691705 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8591802 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 8591802 — Safety Biomarker (SAF): CCKAR
Study 2612091 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 2612091 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2612091 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11403365 — Surrogate Endpoint (SUR): Blood pressure
Study 11403365 — Surrogate Endpoint (SUR): Serum creatinine
Study 9814867 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 3358819 — Surrogate Endpoint (SUR): Blood pressure
Study 3057120 — Surrogate Endpoint (SUR): Blood pressure
Study 11709606 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 11709606 — Surrogate Endpoint (SUR): Bone mineral density
Study 11709606 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 8196493 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 30380017 — Surrogate Endpoint (SUR): Blood pressure
Study 30380017 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16822845 — Surrogate Endpoint (SUR): Bone mineral density
Study 11400961 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 30932012 — Predictive Biomarker (PRD): SLC5A5 mRNA
Genes: SLC5A5; NIS
Study 30932012 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 23913656 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 21143421 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 8277478 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 21806682 — Surrogate Endpoint (SUR): Probing pocket depth
Study 16227760 — Surrogate Endpoint (SUR): Blood pressure
Study 11863257 — Surrogate Endpoint (SUR): Blood pressure
Study 7747690 — Surrogate Endpoint (SUR): Blood pressure
Study 6733833 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 6733833 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30761717 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22595172 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22595172 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 19246508 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 26633836 — Predictive Biomarker (PRD): LTA mRNA
Genes: LTA; TNFB; TNFSF1
Study 26633836 — Predictive Biomarker (PRD): MEA1 mRNA
Genes: MEA1; MEA
Study 22341062 — Predictive Biomarker (PRD): KCNN3 mRNA
Genes: KCNN3; K3
Study 16130506 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 9284668 — Surrogate Endpoint (SUR): Blood pressure
Study 27342654 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27342654 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27342654 — Surrogate Endpoint (SUR): Serum creatinine
Study 10028925 — Surrogate Endpoint (SUR): Blood pressure
Study 1975187 — Surrogate Endpoint (SUR): Blood pressure
Study 23955552 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 17174729 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 21044908 — Predictive Biomarker (PRD): ARC mRNA
Genes: ARC; KIAA0278
Study 18551200 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 12906020 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30523029 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 12204864 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 9814452 — Surrogate Endpoint (SUR): Bone mineral density
Study 2713213 — Surrogate Endpoint (SUR): Blood pressure
Study 30295425 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29066265 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 29066265 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25361982 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 25361982 — Predictive Biomarker (PRD): Microsatellite instability
Study 21593118 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 10904284 — Surrogate Endpoint (SUR): Blood pressure
Study 10904284 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8462390 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 2939208 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 2939208 — Surrogate Endpoint (SUR): Blood pressure
Study 22514244 — Surrogate Endpoint (SUR): Serum creatinine
Study 15947110 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 12067231 — Predictive Biomarker (PRD): SERPINF1 mRNA
Genes: SERPINF1; PEDF; PIG35
Study 25044535 — Surrogate Endpoint (SUR): Blood pressure
Study 22414964 — Safety Biomarker (SAF): Reactive oxygen species