TrialPanorama/TrialPanorama-database huggingface dataset:
Study 30925953 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 30925953 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 19542238 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29502065 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29502065 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 29502065 — Surrogate Endpoint (SUR): Blood pressure
Study 25561147 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25561147 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17156341 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 30247174 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 14992903 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 9385282 — Surrogate Endpoint (SUR): Bone mineral density
Study 9385282 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 31163974 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 31163974 — Surrogate Endpoint (SUR): Serum creatinine
Study 28199818 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 28199818 — Predictive Biomarker (PRD): AXL mRNA
Genes: AXL; UFO
Study 28199818 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25956286 — Surrogate Endpoint (SUR): Bone mineral density
Study 23464664 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 18590587 — Predictive Biomarker (PRD): IGDCC4 mRNA
Genes: IGDCC4; DDM36; KIAA1628; NOPE
Study 14764783 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 3450522 — Surrogate Endpoint (SUR): Blood pressure
Study 27825313 — Surrogate Endpoint (SUR): Blood pressure
Study 10702175 — Safety Biomarker (SAF): Reactive oxygen species
Study 8836263 — Surrogate Endpoint (SUR): Forced vital capacity
Study 8836263 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 1290723 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 31005162 — Predictive Biomarker (PRD): PLN mRNA
Genes: PLN; PLB
Study 25126027 — Surrogate Endpoint (SUR): Blood pressure
Study 17526166 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17526166 — Safety Biomarker (SAF): Interleukin 1
Study 8242291 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8242291 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25089313 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 25398294 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 1878231 — Surrogate Endpoint (SUR): Blood pressure
Study 15894901 — Surrogate Endpoint (SUR): Blood pressure
Study 1770472 — Surrogate Endpoint (SUR): Blood pressure
Study 22525654 — Surrogate Endpoint (SUR): Blood pressure
Study 20071560 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 16085529 — Predictive Biomarker (PRD): CPD mRNA
Genes: CPD
Study 12107206 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 10053098 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 10053098 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29549243 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 29549243 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 19
Genes: FGF19; UNQ334/PRO533
Study 18413195 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18413195 — Surrogate Endpoint (SUR): Blood pressure
Study 28414061 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 28414061 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18246681 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 26978413 — Surrogate Endpoint (SUR): Blood pressure
Study 22455403 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 31958281 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28158510 — Surrogate Endpoint (SUR): Blood pressure
Study 23340449 — Predictive Biomarker (PRD): ODC1 mRNA
Genes: ODC1
Study 21658349 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 19374892 — Predictive Biomarker (PRD): SLCO1B1 mRNA
Genes: SLCO1B1; LST1; OATP1B1; OATP2; OATPC; SLC21A6
Study 19374892 — Safety Biomarker (SAF): SLCO1B1
Genes: OATP-C; LST-1; OATP1B1
Study 17088091 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 17088091 — Surrogate Endpoint (SUR): Serum potassium
Study 17088091 — Surrogate Endpoint (SUR): Blood pressure
Study 16485735 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 18329563 — Surrogate Endpoint (SUR): Blood pressure
Study 16401810 — Monitoring Biomarker (MOI): HBV DNA
Study 11428837 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9284986 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 17534380 — Surrogate Endpoint (SUR): Blood pressure
Study 12654170 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30334082 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 30334082 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30334082 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 30334082 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 24884787 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 19748619 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 3907792 — Surrogate Endpoint (SUR): Blood pressure
Study 27349747 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 27349747 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 30558672 — Safety Biomarker (SAF): Hyaluronic acid
Study 26940095 — Predictive Biomarker (PRD): GSTM1 mRNA
Genes: GSTM1; GST1
Study 26940095 — Predictive Biomarker (PRD): APOL1 mRNA
Genes: APOL1; APOL
Study 10023697 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 25299668 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25299668 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25299668 — Surrogate Endpoint (SUR): Blood pressure
Study 15949431 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 7103524 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7103524 — Surrogate Endpoint (SUR): Serum triglycerides
Study 26765633 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Neurofilament light polypeptide
Genes: NEFL; NF68; NFL
Study 10596413 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30400947 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 24012456 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 21345850 — Surrogate Endpoint (SUR): Blood pressure
Study 15042537 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15042537 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1464862 — Surrogate Endpoint (SUR): Bone mineral density
Study 24567279 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 17989600 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 17989600 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2163805 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 30382002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15105978 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 31141465 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31141465 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15906076 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 15906076 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15906076 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 8636343 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 6168840 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 6168840 — Surrogate Endpoint (SUR): Serum calcium
Study 11679989 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 11679989 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 9461726 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 8003847 — Surrogate Endpoint (SUR): Bone mineral density
Study 3341390 — Surrogate Endpoint (SUR): Blood pressure
Study 26514499 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 21138901 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19091420 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 19091420 — Predictive Biomarker (PRD): GLS2 mRNA
Genes: GLS2; GA
Study 19091420 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 18693603 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 3415794 — Surrogate Endpoint (SUR): Blood pressure
Study 31876907 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 31539276 — Predictive Biomarker (PRD): KCNMB2 mRNA
Genes: KCNMB2
Study 31539276 — Predictive Biomarker (PRD): PTGDR mRNA
Genes: PTGDR
Study 31539276 — Predictive Biomarker (PRD): BACH2 mRNA
Genes: BACH2
Study 31539276 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31539276 — Predictive Biomarker (PRD): NUF2 mRNA
Genes: NUF2; CDCA1; NUF2R
Study 31539276 — Predictive Biomarker (PRD): PTTG1 mRNA
Genes: PTTG1; EAP1; PTTG; TUTR1
Study 26390102 — Surrogate Endpoint (SUR): Blood pressure
Study 11023194 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 27751762 — Surrogate Endpoint (SUR): Blood pressure
Study 10337856 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30581100 — Predictive Biomarker (PRD): MTOR mRNA
Genes: MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1
Study 30581100 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28744114 — Surrogate Endpoint (SUR): Blood pressure
Study 9819786 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9819786 — Surrogate Endpoint (SUR): Blood pressure
Study 24330156 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22374985 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 11726010 — Surrogate Endpoint (SUR): Blood pressure
Study 11726010 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9164833 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 29571007 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8760535 — Surrogate Endpoint (SUR): Blood pressure
Study 31449874 — Predictive Biomarker (PRD): NPY mRNA
Genes: NPY
Study 31449874 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26572756 — Surrogate Endpoint (SUR): Bone mineral density
Study 2894357 — Surrogate Endpoint (SUR): Blood pressure
Study 19896172 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 7131540 — Surrogate Endpoint (SUR): Blood pressure
Study 12490789 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 12490789 — Surrogate Endpoint (SUR): Serum creatinine
Study 14689023 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 14689023 — Surrogate Endpoint (SUR): Blood pressure
Study 20434400 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 20434400 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 18324951 — Surrogate Endpoint (SUR): Bone mineral density
Study 3790399 — Surrogate Endpoint (SUR): Blood pressure
Study 19156087 — Predictive Biomarker (PRD): DDC mRNA
Genes: DDC; AADC
Study 8053282 — Surrogate Endpoint (SUR): Blood pressure
Study 29659969 — Surrogate Endpoint (SUR): Blood pressure
Study 30448517 — Monitoring Biomarker (MOI): Procalcitonin
Study 30448517 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 21419356 — Surrogate Endpoint (SUR): Blood pressure
Study 17692748 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 17692748 — Surrogate Endpoint (SUR): Blood pressure
Study 8219653 — Surrogate Endpoint (SUR): Blood pressure
Study 18996379 — Predictive Biomarker (PRD): HGD mRNA
Genes: HGD; HGO
Study 2439818 — Surrogate Endpoint (SUR): Blood pressure
Study 2439818 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31910432 — Predictive Biomarker (PRD): ARL6IP4 mRNA
Genes: ARL6IP4
Study 23190756 — Predictive Biomarker (PRD): HPSE mRNA
Genes: HPSE; HEP; HPA; HPA1; HPR1; HPSE1; HSE1
Study 22097203 — Surrogate Endpoint (SUR): Bone mineral density
Study 19541504 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16274713 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9028548 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 1970107 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 31317694 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 26745694 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 26745694 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 17973781 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15459842 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 10346660 — Surrogate Endpoint (SUR): Blood pressure
Study 7978476 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 7978476 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 1 beta
Genes: IL1B; IL1F2
Study 7978476 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7978476 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 7978476 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 7978476 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19327425 — Surrogate Endpoint (SUR): Blood pressure
Study 28870052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19815293 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 14667511 — Surrogate Endpoint (SUR): Bone mineral density
Study 6851036 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22018763 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 19571804 — Surrogate Endpoint (SUR): Blood pressure
Study 18190257 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15045702 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 15045702 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11254910 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27046320 — Surrogate Endpoint (SUR): Blood pressure
Study 12479049 — Predictive Biomarker (PRD): CNP mRNA
Genes: CNP
Study 9656040 — Surrogate Endpoint (SUR): Blood pressure
Study 24142540 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 9707653 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 17985062 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 17985062 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8018909 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 21641360 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21641360 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16275171 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 9053491 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 15930487 — Surrogate Endpoint (SUR): Serum triglycerides
Study 22872657 — Surrogate Endpoint (SUR): Blood pressure
Study 19213607 — Safety Biomarker (SAF): Hyaluronic acid
Study 17693690 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14551140 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 8023659 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8023659 — Surrogate Endpoint (SUR): Forced vital capacity
Study 31198939 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 11981152 — Surrogate Endpoint (SUR): Blood pressure
Study 9857856 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28206704 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 12243825 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 12117292 — Predictive Biomarker (PRD): ITGB2 mRNA
Genes: ITGB2; CD18; MFI7
Study 12117292 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 21910711 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 1960558 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 28933133 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28933133 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19545977 — Predictive Biomarker (PRD): USH1G mRNA
Genes: USH1G; SANS
Study 14748765 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11231376 — Surrogate Endpoint (SUR): Blood pressure
Study 31537217 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31537217 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26905864 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 1725544 — Surrogate Endpoint (SUR): Blood pressure
Study 23537462 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 14712421 — Predictive Biomarker (PRD): RCN1 mRNA
Genes: RCN1; RCN
Study 14712421 — Surrogate Endpoint (SUR): Serum creatinine
Study 21902686 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 21902686 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8726152 — Predictive Biomarker (PRD): MMD mRNA
Genes: MMD; PAQR11
Study 31655296 — Predictive Biomarker (PRD): CDK6 mRNA
Genes: CDK6; CDKN6
Study 31655296 — Predictive Biomarker (PRD): RBL2 mRNA
Genes: RBL2; RB2
Study 31655296 — Pharmacodynamic Biomarker (PDY): Retinoblastoma-associated protein
Genes: RB1
Study 31655296 — Predictive Biomarker (PRD): Aurora kinase A
Genes: AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6
Study 22181685 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 22181685 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 19907002 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 19907002 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 19907002 — Predictive Biomarker (PRD): TFAM mRNA
Genes: TFAM; TCF6; TCF6L2
Study 19907002 — Predictive Biomarker (PRD): NKRF mRNA
Genes: NKRF; ITBA4; NRF
Study 8583019 — Surrogate Endpoint (SUR): Probing pocket depth
Study 28027911 — Surrogate Endpoint (SUR): Blood pressure
Study 25692980 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 31262847 — Surrogate Endpoint (SUR): Blood pressure
Study 25582279 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 30958572 — Pharmacodynamic Biomarker (PDY): Ataxin-2
Genes: ATXN2; ATX2; SCA2; TNRC13
Study 25314964 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 15111142 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 27402556 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 1942470 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 1942470 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 24102416 — Surrogate Endpoint (SUR): Blood pressure
Study 17552881 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15919731 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15919731 — Surrogate Endpoint (SUR): Blood pressure
Study 14526208 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8893678 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 8893678 — Predictive Biomarker (PRD): SERPINA6 mRNA
Genes: SERPINA6; CBG
Study 8893678 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8393589 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 27977392 — Surrogate Endpoint (SUR): Blood pressure
Study 27977392 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25496294 — Surrogate Endpoint (SUR): Blood pressure
Study 31027457 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31027457 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2