TrialPanorama/TrialPanorama-database huggingface dataset:
Study 19707226 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 18260869 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18260869 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 18260869 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 15380903 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 15380903 — Surrogate Endpoint (SUR): Blood pressure
Study 9661650 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 9661650 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16643825 — Surrogate Endpoint (SUR): Blood pressure
Study 11142421 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 6202387 — Predictive Biomarker (PRD): MERTK mRNA
Genes: MERTK; MER
Study 20079178 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 20079178 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 20079178 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 11669411 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28592751 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15461825 — Surrogate Endpoint (SUR): Blood pressure
Study 8956701 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29235555 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 15975312 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 12708881 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12708881 — Surrogate Endpoint (SUR): Blood pressure
Study 1960829 — Surrogate Endpoint (SUR): Blood pressure
Study 1960829 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7128954 — Surrogate Endpoint (SUR): Plasma ammonia
Study 31534016 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31534016 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 28369286 — Surrogate Endpoint (SUR): Bone mineral density
Study 23907810 — Surrogate Endpoint (SUR): Serum potassium
Study 20082253 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15624743 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 11180037 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 7986789 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22318965 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22318965 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 22318965 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17150279 — Safety Biomarker (SAF): Cytotoxic T-lymphocyte protein 4
Genes: CTLA4; CD152
Study 8884559 — Surrogate Endpoint (SUR): Blood pressure
Study 1304463 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 28671097 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 28671097 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 28671097 — Predictive Biomarker (PRD): IL33 mRNA
Genes: IL33; C9orf26; IL1F11; NFHEV
Study 9227301 — Surrogate Endpoint (SUR): Blood pressure
Study 8482617 — Surrogate Endpoint (SUR): Blood pressure
Study 3546936 — Predictive Biomarker (PRD): SFPQ mRNA
Genes: SFPQ; PSF
Study 15580380 — Surrogate Endpoint (SUR): Serum calcium
Study 11395039 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 7826564 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7826564 — Surrogate Endpoint (SUR): Blood pressure
Study 27424564 — Predictive Biomarker (PRD): ARC mRNA
Genes: ARC; KIAA0278
Study 2285642 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2285642 — Surrogate Endpoint (SUR): Blood pressure
Study 31092196 — Predictive Biomarker (PRD): RB1
Genes: RB; PPP1R130
Study 19204205 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 19204205 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 3281411 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 3281411 — Surrogate Endpoint (SUR): Blood pressure
Study 18437173 — Predictive Biomarker (PRD): TMPRSS2 mRNA
Genes: TMPRSS2; PRSS10
Study 11783329 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 20978446 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 20119647 — Safety Biomarker (SAF): Pentraxin-related protein PTX3
Genes: PTX3; TNFAIP5; TSG14
Study 20119647 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 18559700 — Surrogate Endpoint (SUR): Blood pressure
Study 24815497 — Surrogate Endpoint (SUR): Blood pressure
Study 20605301 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 7636779 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7636779 — Surrogate Endpoint (SUR): Blood pressure
Study 28506550 — Predictive Biomarker (PRD): MAPK3 mRNA
Genes: MAPK3; ERK1; PRKM3
Study 28506550 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 25856039 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 25856039 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 19916253 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 19916253 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 25975632 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 25975632 — Surrogate Endpoint (SUR): Pathological complete response
Study 20012308 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20012308 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20012308 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7861706 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 7861706 — Surrogate Endpoint (SUR): Blood pressure
Study 11822980 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 7557275 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 29949407 — Surrogate Endpoint (SUR): Blood pressure
Study 29949407 — Surrogate Endpoint (SUR): Serum sodium
Study 15841592 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 9802745 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 19145455 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14963675 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14963675 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 14963675 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16575033 — Surrogate Endpoint (SUR): Blood pressure
Study 11294060 — Safety Biomarker (SAF): DRD3
Study 25378974 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16700870 — Surrogate Endpoint (SUR): Blood pressure
Study 12764905 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12764905 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12764905 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25909982 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 22496093 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22496093 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22496093 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 21645332 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24211172 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 24211172 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 23314695 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23314695 — Monitoring Biomarker (MOI): Procalcitonin
Study 16210048 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 2473515 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 27188795 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 10569644 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8906516 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1878735 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 24707021 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24707021 — Surrogate Endpoint (SUR): Blood pressure
Study 24707021 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12197195 — Surrogate Endpoint (SUR): Blood pressure
Study 29476238 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 29476238 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19204509 — Surrogate Endpoint (SUR): Blood pressure
Study 15059636 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15059636 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7538815 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 2177394 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 30229398 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 11218929 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 28099236 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28099236 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 28099236 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 28099236 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25847401 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23521170 — Surrogate Endpoint (SUR): Blood pressure
Study 22039471 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 1097220 — Predictive Biomarker (PRD): ITPA mRNA
Genes: ITPA; C20orf37; My049; OK/SW-cl.9
Study 17549293 — Predictive Biomarker (PRD): Coagulation factor VIII
Genes: F8; F8C
Study 17549293 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 27256575 — Surrogate Endpoint (SUR): Blood pressure
Study 18596389 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 18596389 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 16671363 — Surrogate Endpoint (SUR): Blood pressure
Study 12110423 — Surrogate Endpoint (SUR): Bone mineral density
Study 282051 — Surrogate Endpoint (SUR): Blood pressure
Study 23490226 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 19628108 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19628108 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19628108 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 19628108 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19628108 — Surrogate Endpoint (SUR): Blood pressure
Study 26940688 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 26940688 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 12829991 — Monitoring Biomarker (MOI): HBV DNA
Study 8857016 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 30439309 — Monitoring Biomarker (MOI): Procalcitonin
Study 30439309 — Monitoring Biomarker (MOI): Cell-free DNA
Study 27050801 — Predictive Biomarker (PRD): ADRB2 mRNA
Genes: ADRB2; ADRB2R; B2AR
Study 11576365 — Surrogate Endpoint (SUR): Serum creatinine
Study 26303195 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10225505 — Predictive Biomarker (PRD): ZFP36 mRNA
Genes: ZFP36; G0S24; NUP475; RNF162A; TIS11A; TTP
Study 23410138 — Surrogate Endpoint (SUR): Blood pressure
Study 18312558 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18312558 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18312558 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17634547 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 17634547 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 12445218 — Predictive Biomarker (PRD): RALA mRNA
Genes: RALA; RAL
Study 8765382 — Surrogate Endpoint (SUR): Blood pressure
Study 22846686 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17967673 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 19567547 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11165354 — Surrogate Endpoint (SUR): Blood pressure
Study 16649224 — Predictive Biomarker (PRD): ERCC2 mRNA
Genes: ERCC2; XPD; XPDC
Study 11392165 — Predictive Biomarker (PRD): TPO mRNA
Genes: TPO
Study 29381229 — Predictive Biomarker (PRD): GPC3 mRNA
Genes: GPC3; OCI5
Study 29381229 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 29381229 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22751603 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15158303 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 2914153 — Surrogate Endpoint (SUR): Blood pressure
Study 20978247 — Pharmacodynamic Biomarker (PDY): Transmembrane glycoprotein NMB
Genes: GPNMB; HGFIN; NMB; UNQ1725/PRO9925
Study 19328860 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 16942566 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 10811145 — Surrogate Endpoint (SUR): Bone mineral density
Study 23490403 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 20886606 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 15150203 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 11212974 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11212974 — Surrogate Endpoint (SUR): Blood pressure
Study 30989330 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 29118371 — Safety Biomarker (SAF): miR-137
Genes: MIR137
Study 29118371 — Predictive Biomarker (PRD): CPLX1 mRNA
Genes: CPLX1
Study 23114287 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 23114287 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 19459146 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19459146 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 19459146 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15544576 — Predictive Biomarker (PRD): TPH1 mRNA
Genes: TPH1; TPH; TPRH; TRPH
Study 11153670 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6810527 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 24993934 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 24462367 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 24462367 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 19008862 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19008862 — Surrogate Endpoint (SUR): Blood pressure
Study 2009894 — Surrogate Endpoint (SUR): Blood pressure
Study 23539534 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12635671 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12635671 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 12635671 — Predictive Biomarker (PRD): KCNMA1 mRNA
Genes: KCNMA1; KCNMA; SLO
Study 12635671 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 12635671 — Surrogate Endpoint (SUR): Blood pressure
Study 10848925 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 28440343 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 26400818 — Surrogate Endpoint (SUR): Blood pressure
Study 30102338 — Predictive Biomarker (PRD): FBXO11 mRNA
Genes: FBXO11; FBX11; PRMT9; VIT1; UG063H01
Study 25041620 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 22211683 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15792396 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 7049587 — Surrogate Endpoint (SUR): Serum potassium
Study 7049587 — Surrogate Endpoint (SUR): Blood pressure
Study 15904654 — Surrogate Endpoint (SUR): Blood pressure
Study 7943676 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31648705 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31648705 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9575599 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8222122 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29426300 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 29426300 — Surrogate Endpoint (SUR): Serum calcium
Study 28861980 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 15918822 — Surrogate Endpoint (SUR): Blood pressure
Study 12911187 — Surrogate Endpoint (SUR): New morphometric vertebral fractures
Study 10561733 — Predictive Biomarker (PRD): TNFR1B
Genes: TNFRSF1B; TNFBR; TNFR80; TNF-R75; TNF-R-II; p75; CD120b
Study 10561733 — Safety Biomarker (SAF): Interleukin 1
Study 10561733 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 8297564 — Surrogate Endpoint (SUR): Blood pressure
Study 8297564 — Surrogate Endpoint (SUR): Serum sodium
Study 8297564 — Surrogate Endpoint (SUR): Serum calcium
Study 12584227 — Monitoring Biomarker (MOI): HBV DNA
Study 11021956 — Surrogate Endpoint (SUR): Blood pressure
Study 9256871 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 1328400 — Predictive Biomarker (PRD): GJA1 mRNA
Genes: GJA1; GJAL
Study 21463799 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21463799 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16936991 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16936991 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8453193 — Surrogate Endpoint (SUR): Bone mineral density
Study 2894489 — Surrogate Endpoint (SUR): Blood pressure
Study 19032172 — Surrogate Endpoint (SUR): Blood pressure
Study 30591062 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24772594 — Surrogate Endpoint (SUR): Blood pressure
Study 12500022 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12500022 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28803333 — Surrogate Endpoint (SUR): Serum sodium
Study 19414053 — Predictive Biomarker (PRD): EDA mRNA
Genes: EDA; ED1; EDA2
Study 7988196 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7988196 — Safety Biomarker (SAF): Interleukin 1
Study 7988196 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7988196 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 18387160 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 11273797 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 28611897 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 22718278 — Predictive Biomarker (PRD): HOXB13 mRNA
Genes: HOXB13
Study 27664561 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27664561 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24860173 — Surrogate Endpoint (SUR): Blood pressure
Study 19690268 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19690268 — Surrogate Endpoint (SUR): Serum creatinine
Study 19690268 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 11751742 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11751742 — Surrogate Endpoint (SUR): Blood pressure
Study 29708654 — Surrogate Endpoint (SUR): Probing pocket depth