TrialPanorama/TrialPanorama-database huggingface dataset:
Study 24461797 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 11964594 — Surrogate Endpoint (SUR): Blood pressure
Study 8545528 — Predictive Biomarker (PRD): HAL mRNA
Genes: HAL; HIS
Study 26489051 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9545672 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 26711179 — Surrogate Endpoint (SUR): Blood pressure
Study 1813067 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 21982425 — Surrogate Endpoint (SUR): Blood pressure
Study 28216660 — Surrogate Endpoint (SUR): Minimal residual disease response rate
Study 25813447 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 14761115 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30001171 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26519191 — Predictive Biomarker (PRD): SLCO1A2 mRNA
Genes: SLCO1A2; OATP; OATP1; OATP1A2; SLC21A3
Study 24790703 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24790703 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 22142020 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 17451415 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 12564661 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3588512 — Surrogate Endpoint (SUR): Blood pressure
Study 12660530 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24576686 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 22133572 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 17414590 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 30685298 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30685298 — Pharmacodynamic Biomarker (PDY): Cathepsin S
Genes: CTSS
Study 30685298 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 30685298 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1742815 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1742815 — Surrogate Endpoint (SUR): Blood pressure
Study 14759453 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 14759453 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14759453 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 3549083 — Surrogate Endpoint (SUR): Serum creatinine
Study 17586139 — Monitoring Biomarker (MOI): Matrix metalloproteinase 1
Genes: MMP1; CLG
Study 17586139 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 12075915 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 10605950 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 10605950 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 25387477 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16076944 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10404735 — Surrogate Endpoint (SUR): Blood pressure
Study 7590502 — Surrogate Endpoint (SUR): Blood pressure
Study 6766833 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 31332998 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 25878177 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 27757829 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27757829 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23937012 — Surrogate Endpoint (SUR): Blood pressure
Study 15139978 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31542965 — Surrogate Endpoint (SUR): Blood pressure
Study 17355732 — Surrogate Endpoint (SUR): Serum creatinine
Study 11996956 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 11996956 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23810626 — Surrogate Endpoint (SUR): Blood pressure
Study 20085534 — Surrogate Endpoint (SUR): Blood pressure
Study 8997168 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8997168 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 6712863 — Surrogate Endpoint (SUR): Blood pressure
Study 30824398 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18485759 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 15851366 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15851366 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25546001 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 23630016 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 7922794 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 25904376 — Predictive Biomarker (PRD): RALA mRNA
Genes: RALA; RAL
Study 25904376 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 25904376 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 25904376 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 25904376 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19266214 — Surrogate Endpoint (SUR): Blood pressure
Study 19266214 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19266214 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23577719 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 23577719 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 22010914 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31232275 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 27885712 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27885712 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 27885712 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 27885712 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16823726 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 23803696 — Predictive Biomarker (PRD): ITGB2 mRNA
Genes: ITGB2; CD18; MFI7
Study 23803696 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 23803696 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 23803696 — Predictive Biomarker (PRD): MYD88 mRNA
Genes: MYD88
Study 22032072 — Surrogate Endpoint (SUR): Blood pressure
Study 29697830 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 12962794 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 23599623 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23599623 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 23599623 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19289857 — Surrogate Endpoint (SUR): Blood pressure
Study 27004531 — Surrogate Endpoint (SUR): Blood pressure
Study 23511711 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 18387161 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 18387161 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 6356855 — Surrogate Endpoint (SUR): Blood pressure
Study 31857319 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 18628467 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 15959537 — Surrogate Endpoint (SUR): Blood pressure
Study 11840030 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 2521997 — Surrogate Endpoint (SUR): Forced vital capacity
Study 2521997 — Surrogate Endpoint (SUR): Blood pressure
Study 26972358 — Safety Biomarker (SAF): Hyaluronic acid
Study 24716681 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 22425308 — Surrogate Endpoint (SUR): Bone mineral density
Study 18079051 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 11423583 — Surrogate Endpoint (SUR): Bone mineral density
Study 8994481 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7957469 — Predictive Biomarker (PRD): CEACAM6 mRNA
Genes: CEACAM6; NCA
Study 31748467 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30972995 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 1318281 — Surrogate Endpoint (SUR): Blood pressure
Study 26963316 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 25130297 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 383417 — Surrogate Endpoint (SUR): Forced vital capacity
Study 26140739 — Surrogate Endpoint (SUR): Blood pressure
Study 21134995 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21134995 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 23735746 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9005419 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 9005419 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 2072371 — Surrogate Endpoint (SUR): Blood pressure
Study 28961833 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 28961833 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 28961833 — Predictive Biomarker (PRD): ERBB3 mRNA
Genes: ERBB3; HER3
Study 28961833 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 28961833 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 19416946 — Predictive Biomarker (PRD): AGER mRNA
Genes: AGER; RAGE
Study 19416946 — Surrogate Endpoint (SUR): Bone mineral density
Study 9555954 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8956759 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 2951800 — Surrogate Endpoint (SUR): Forced vital capacity
Study 2951800 — Surrogate Endpoint (SUR): Blood pressure
Study 30012361 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 30012361 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 22704111 — Predictive Biomarker (PRD): Activated leukocyte cell adhesionmolecule
Genes: ALCAM; MEMD
Study 18711169 — Predictive Biomarker (PRD): PITX2 mRNA
Genes: PITX2; ARP1; RGS; RIEG; RIEG1
Study 18711169 — Predictive Biomarker (PRD): Hormone receptor
Study 1330411 — Surrogate Endpoint (SUR): Blood pressure
Study 25550339 — Surrogate Endpoint (SUR): Complete renal response
Study 22331646 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22331646 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19289319 — Surrogate Endpoint (SUR): Blood pressure
Study 11529904 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 3278190 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3278190 — Surrogate Endpoint (SUR): Serum uric acid
Study 10904511 — Surrogate Endpoint (SUR): Blood pressure
Study 8363025 — Surrogate Endpoint (SUR): Blood pressure
Study 28522130 — Surrogate Endpoint (SUR): Bone mineral density
Study 29152839 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 24023271 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 20461009 — Predictive Biomarker (PRD): MUC2 mRNA
Genes: MUC2; SMUC
Study 20461009 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Trefoil factor 3
Genes: TFF3; ITF; TFI
Study 31183985 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 19733719 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19733719 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10212375 — Surrogate Endpoint (SUR): Blood pressure
Study 19167814 — Surrogate Endpoint (SUR): Blood pressure
Study 11756319 — Predictive Biomarker (PRD): SLC2A1 mRNA
Genes: SLC2A1; GLUT1
Study 11756319 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 2655688 — Surrogate Endpoint (SUR): Blood pressure
Study 21349458 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24009042 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 24009042 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 24009042 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 20972299 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19260871 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 28051345 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28051345 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 21982167 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 28187765 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28187765 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28187765 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23377391 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 15340332 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11938803 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 11938803 — Surrogate Endpoint (SUR): Serum creatinine
Study 1383924 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 1383924 — Safety Biomarker (SAF): OPRM1
Genes: MOR1; MOP
Study 28651616 — Predictive Biomarker (PRD): PTGDS mRNA
Genes: PTGDS; PDS
Study 25481367 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25481367 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 25481367 — Surrogate Endpoint (SUR): Blood pressure
Study 21493022 — Surrogate Endpoint (SUR): Blood pressure
Study 14760156 — Predictive Biomarker (PRD): MVP mRNA
Genes: MVP; LRP
Study 28399028 — Predictive Biomarker (PRD): ERBIN mRNA
Genes: ERBIN; ERBB2IP; KIAA1225; LAP2
Study 26665553 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26665553 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 21638037 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 21638037 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21638037 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 12927315 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 18506154 — Predictive Biomarker (PRD): MTTP mRNA
Genes: MTTP; MTP
Study 11451757 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24366725 — Predictive Biomarker (PRD): ADRB2 mRNA
Genes: ADRB2; ADRB2R; B2AR
Study 15356071 — Surrogate Endpoint (SUR): Blood pressure
Study 2675962 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 2675962 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 25361738 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 24268098 — Predictive Biomarker (PRD): ANKS4B mRNA
Genes: ANKS4B; HARP
Study 19755964 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11846847 — Surrogate Endpoint (SUR): Probing pocket depth
Study 9885792 — Surrogate Endpoint (SUR): Blood pressure
Study 8771612 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 25212696 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19102515 — Surrogate Endpoint (SUR): Blood pressure
Study 15219499 — Surrogate Endpoint (SUR): Blood pressure
Study 9469527 — Predictive Biomarker (PRD): LEP mRNA
Genes: LEP; OB; OBS
Study 9469527 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 29535130 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 10339732 — Surrogate Endpoint (SUR): Bone mineral density
Study 8984131 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8984131 — Surrogate Endpoint (SUR): Blood pressure
Study 24840781 — Surrogate Endpoint (SUR): Serum calcium
Study 17019594 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17019594 — Surrogate Endpoint (SUR): Blood pressure
Study 28855976 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 26547357 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 11237920 — Surrogate Endpoint (SUR): Blood pressure
Study 30666023 — Surrogate Endpoint (SUR): Blood pressure
Study 17721621 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 15982605 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15982605 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20639712 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 16644278 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 10831925 — Surrogate Endpoint (SUR): Bone mineral density
Study 1346182 — Surrogate Endpoint (SUR): Blood pressure
Study 6202963 — Surrogate Endpoint (SUR): Blood pressure
Study 29947235 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29947235 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 12808486 — Surrogate Endpoint (SUR): Blood pressure
Study 12808486 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12808486 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12808486 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12808486 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 16360360 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16360360 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16360360 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 12058096 — Predictive Biomarker (PRD): EEF1A2 mRNA
Genes: EEF1A2; EEF1AL; STN
Study 1483483 — Surrogate Endpoint (SUR): Blood pressure
Study 2990711 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 10190404 — Surrogate Endpoint (SUR): Blood pressure
Study 23230311 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23230311 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23230311 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 15174325 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 11697832 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 31901710 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31901710 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 31901710 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28382551 — Surrogate Endpoint (SUR): Bone mineral density
Study 25719419 — Safety Biomarker (SAF): Hyaluronic acid
Study 17034279 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 12514268 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12514268 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 12514268 — Predictive Biomarker (PRD): LDLR mRNA
Genes: LDLR
Study 10882617 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31250552 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31250552 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31250552 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 31250552 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 29363988 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29363988 — Surrogate Endpoint (SUR): Blood pressure
Study 18280335 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 12679443 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 16339498 — Safety Biomarker (SAF): Coagulation factor IIa
Genes: F2
Study 8840306 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8840306 — Safety Biomarker (SAF): Interleukin 1
Study 8840306 — Surrogate Endpoint (SUR): Serum intact parathyroid hormone
Study 8840306 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 3885699 — Surrogate Endpoint (SUR): Blood pressure
Study 27175664 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 27175664 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 27175664 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16622039 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 29061224 — Safety Biomarker (SAF): Clusterin
Genes: CLU; APOJ; CLI; KUB1; AAG4
Study 29061224 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 22018594 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 22018594 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF