TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23291565 — Surrogate Endpoint (SUR): Bone mineral density
Study 20974593 — Predictive Biomarker (PRD): PGD mRNA
Genes: PGD; PGDH
Study 8615394 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 24835247 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24835247 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 24835247 — Safety Biomarker (SAF): Interleukin 1
Study 9708651 — Surrogate Endpoint (SUR): Blood pressure
Study 26869609 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 20587587 — Surrogate Endpoint (SUR): Blood pressure
Study 7802296 — Surrogate Endpoint (SUR): Serum potassium
Study 31226144 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11186094 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 28319589 — Surrogate Endpoint (SUR): Blood pressure
Study 21972946 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 11726420 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 11726420 — Surrogate Endpoint (SUR): Blood pressure
Study 27562221 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 15268733 — Surrogate Endpoint (SUR): Blood pressure
Study 24859356 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 24859356 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 16157616 — Surrogate Endpoint (SUR): Blood pressure
Study 12814712 — Surrogate Endpoint (SUR): Serum creatinine
Study 28913927 — Safety Biomarker (SAF): Hyaluronic acid
Study 24118703 — Predictive Biomarker (PRD): BOC mRNA
Genes: BOC; UNQ604/PRO1190
Study 18275008 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 18275008 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 9952266 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 7490153 — Surrogate Endpoint (SUR): Blood pressure
Study 20934572 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20934572 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 14643272 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10955871 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10727924 — Predictive Biomarker (PRD): LEP mRNA
Genes: LEP; OB; OBS
Study 8772689 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 21962090 — Predictive Biomarker (PRD): NSMAF mRNA
Genes: NSMAF; FAN
Study 28666310 — Surrogate Endpoint (SUR): Blood pressure
Study 17761977 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 24236646 — Surrogate Endpoint (SUR): Blood pressure
Study 16689181 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 20406241 — Surrogate Endpoint (SUR): Blood pressure
Study 10580197 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7593700 — Surrogate Endpoint (SUR): Probing pocket depth
Study 21130513 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 15066879 — Predictive Biomarker (PRD): SDC1 mRNA
Genes: SDC1; SDC
Study 9863994 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 9863994 — Surrogate Endpoint (SUR): Forced vital capacity
Study 29354913 — Surrogate Endpoint (SUR): Serum calcium
Study 18978388 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 8727868 — Safety Biomarker (SAF): 51Cr-EDTA
Study 8727868 — Surrogate Endpoint (SUR): Serum creatinine
Study 24370761 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15199366 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 11383595 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11383595 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31005374 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 16402242 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 9363870 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 1586618 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 3839679 — Surrogate Endpoint (SUR): Blood pressure
Study 31704907 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29310138 — Predictive Biomarker (PRD): MMD mRNA
Genes: MMD; PAQR11
Study 12494803 — Surrogate Endpoint (SUR): Blood pressure
Study 12494803 — Surrogate Endpoint (SUR): Serum potassium
Study 2920500 — Surrogate Endpoint (SUR): Blood pressure
Study 1082383 — Predictive Biomarker (PRD): FUT1 mRNA
Genes: FUT1; H; HSC
Study 16469601 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 11295378 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 29289540 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 9050631 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 9050631 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 29074542 — Predictive Biomarker (PRD): SRC mRNA
Genes: SRC; SRC1
Study 26333723 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 30194492 — Predictive Biomarker (PRD): Hormone receptor
Study 30245148 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 28531784 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28531784 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 9714995 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 9714995 — Surrogate Endpoint (SUR): Blood pressure
Study 9714995 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 12783289 — Surrogate Endpoint (SUR): Serum calcium
Study 19464064 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 22353804 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 22353804 — Predictive Biomarker (PRD): Microsatellite instability
Study 14687173 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 2683921 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2683921 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23224298 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 22089305 — Safety Biomarker (SAF): Reactive oxygen species
Study 8732376 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 2009146 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2009146 — Surrogate Endpoint (SUR): Blood pressure
Study 28798999 — Safety Biomarker (SAF): Reactive oxygen species
Study 9020454 — Surrogate Endpoint (SUR): Blood pressure
Study 8481587 — Surrogate Endpoint (SUR): Bone mineral density
Study 25791185 — Surrogate Endpoint (SUR): Blood pressure
Study 15596634 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 15596634 — Surrogate Endpoint (SUR): Blood pressure
Study 15596634 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15596634 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12606735 — Monitoring Biomarker (MOI): HBV DNA
Study 29352723 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22251482 — Surrogate Endpoint (SUR): Serum creatinine
Study 22251482 — Predictive Biomarker (PRD): Liver iron
Study 17192289 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 7706983 — Predictive Biomarker (PRD): GSR mRNA
Genes: GSR; GLUR; GRD1
Study 11167663 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11167663 — Surrogate Endpoint (SUR): Blood pressure
Study 7488463 — Surrogate Endpoint (SUR): Blood pressure
Study 6996483 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Placenta growth factor
Genes: PGF; PGFL; PLGF
Study 9006811 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6376209 — Surrogate Endpoint (SUR): Serum potassium
Study 31085948 — Surrogate Endpoint (SUR): Blood pressure
Study 24643119 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 24643119 — Safety Biomarker (SAF): BDNF
Study 22295813 — Predictive Biomarker (PRD): ASRGL1 mRNA
Genes: ASRGL1; ALP; CRASH
Study 22295813 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 20814848 — Surrogate Endpoint (SUR): Blood pressure
Study 17491103 — Predictive Biomarker (PRD): CAST mRNA
Genes: CAST
Study 14983409 — Surrogate Endpoint (SUR): Serum testosterone
Study 21410033 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 15830009 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 15830009 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 22429354 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 21890085 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19052047 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 15762970 — Surrogate Endpoint (SUR): Bone mineral density
Study 339214 — Surrogate Endpoint (SUR): Blood pressure
Study 23593633 — Surrogate Endpoint (SUR): Probing pocket depth
Study 19820017 — Surrogate Endpoint (SUR): Bone mineral density
Study 19820017 — Surrogate Endpoint (SUR): Serum testosterone
Study 16829029 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15277409 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 15277409 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23743162 — Surrogate Endpoint (SUR): Blood pressure
Study 14610641 — Surrogate Endpoint (SUR): Bone mineral density
Study 31566309 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 19553931 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 19553931 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15015147 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 17415030 — Predictive Biomarker (PRD): CLNK mRNA
Genes: CLNK; MIST
Study 31859245 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 17376548 — Surrogate Endpoint (SUR): Blood pressure
Study 30672196 — Safety Biomarker (SAF): Interleukin 1
Study 30672196 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 20472253 — Surrogate Endpoint (SUR): Blood pressure
Study 29972000 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 12077684 — Monitoring Biomarker (MOI): Procalcitonin
Study 8749880 — Predictive Biomarker (PRD): MAF mRNA
Genes: MAF
Study 8749880 — Predictive Biomarker (PRD): FHL5 mRNA
Genes: FHL5; ACT
Study 2522723 — Surrogate Endpoint (SUR): Blood pressure
Study 10720278 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 30474909 — Surrogate Endpoint (SUR): Blood pressure
Study 11136913 — Surrogate Endpoint (SUR): Bone mineral density
Study 30829679 — Predictive Biomarker (PRD): EED mRNA
Genes: EED
Study 24294684 — Predictive Biomarker (PRD): UCN3 mRNA
Genes: UCN3; SPC
Study 18270751 — Surrogate Endpoint (SUR): Blood pressure
Study 16487947 — Pharmacodynamic Biomarker (PDY): Mismatch negativity
Study 11051235 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11051235 — Safety Biomarker (SAF): IL-6 and IL-10
Study 2863676 — Surrogate Endpoint (SUR): Forced vital capacity
Study 31345167 — Surrogate Endpoint (SUR): Blood pressure
Study 12391054 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12391054 — Surrogate Endpoint (SUR): Blood pressure
Study 21541815 — Predictive Biomarker (PRD): LEP mRNA
Genes: LEP; OB; OBS
Study 11870241 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 11870241 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 46021 — Surrogate Endpoint (SUR): Blood pressure
Study 25138607 — Predictive Biomarker (PRD): NRF1 mRNA
Genes: NRF1
Study 25138607 — Predictive Biomarker (PRD): SLC27A4 mRNA
Genes: SLC27A4; ACSVL4; FATP4
Study 25138607 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 25138607 — Monitoring Biomarker (MOI): miR-29a
Genes: MIR29A
Study 15087948 — Surrogate Endpoint (SUR): Serum asparaginase
Study 11840364 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 30898984 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 30898984 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 30898984 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 24002370 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24002370 — Surrogate Endpoint (SUR): Blood pressure
Study 21924874 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 31673364 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 25672513 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16115944 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 16115944 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 16115944 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 16115944 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11849865 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11849865 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10094146 — Pharmacodynamic Biomarker (PDY): Mismatch negativity
Study 6142645 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6142645 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25306749 — Surrogate Endpoint (SUR): Blood pressure
Study 20139221 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 15635619 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 10208247 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 6318545 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8535536 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8535536 — Surrogate Endpoint (SUR): Blood pressure
Study 21271793 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21271793 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19432566 — Surrogate Endpoint (SUR): Blood pressure
Study 11747872 — Surrogate Endpoint (SUR): Serum luteinizing hormone
Study 9413765 — Surrogate Endpoint (SUR): Serum sodium
Study 18753925 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18753925 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15961987 — Surrogate Endpoint (SUR): Blood pressure
Study 15961987 — Surrogate Endpoint (SUR): Serum potassium
Study 22217192 — Surrogate Endpoint (SUR): Blood pressure
Study 16259286 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 7479227 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 7479227 — Surrogate Endpoint (SUR): Serum creatinine
Study 7479227 — Surrogate Endpoint (SUR): Blood pressure
Study 2205694 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 9779838 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 9779838 — Safety Biomarker (SAF): IL-6 and IL-10
Study 7512131 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 28318077 — Surrogate Endpoint (SUR): Blood pressure
Study 23011321 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 23011321 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 18261121 — Surrogate Endpoint (SUR): Probing pocket depth
Study 30293689 — Predictive Biomarker (PRD): RB1
Genes: RB; PPP1R130
Study 30293689 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 29931076 — Predictive Biomarker (PRD): TLR8 mRNA
Genes: TLR8; UNQ249/PRO286
Study 18648963 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9432038 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 23653149 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 20691795 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30488542 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 15943593 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 12680748 — Surrogate Endpoint (SUR): Blood pressure
Study 28708126 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 26068295 — Surrogate Endpoint (SUR): Bone mineral density
Study 24727329 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 24727329 — Predictive Biomarker (PRD); Safety Biomarker (SAF): COX2 mRNA
Genes: PTGS2; COX2
Study 20671333 — Predictive Biomarker (PRD): AARS1 mRNA
Genes: AARS1; AARS
Study 11548847 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 11548847 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 7799246 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 9198713 — Surrogate Endpoint (SUR): Blood pressure
Study 19064562 — Predictive Biomarker (PRD): CYP19A1 mRNA
Genes: CYP19A1; ARO1; CYAR; CYP19
Study 10657837 — Predictive Biomarker (PRD): LTB mRNA
Genes: LTB; TNFC; TNFSF3
Study 30084103 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 30084103 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 16107949 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 4412442 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 30883861 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20795924 — Surrogate Endpoint (SUR): Blood pressure
Study 2569857 — Surrogate Endpoint (SUR): Blood pressure
Study 26222725 — Surrogate Endpoint (SUR): Blood pressure
Study 11147785 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 7503064 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11881128 — Surrogate Endpoint (SUR): Blood pressure
Study 2149513 — Surrogate Endpoint (SUR): Blood pressure
Study 25557347 — Surrogate Endpoint (SUR): Blood pressure
Study 23591713 — Surrogate Endpoint (SUR): Bone mineral density
Study 19669785 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 19669785 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 8198020 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10026395 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 1853306 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 27511899 — Predictive Biomarker (PRD): FLT3 mRNA
Genes: FLT3; CD135; FLK2; STK1
Study 27511899 — Safety Biomarker (SAF): miR-155
Genes: MIR155
Study 28318619 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 21594560 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 17211242 — Surrogate Endpoint (SUR): Blood pressure
Study 9692813 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 20146674 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20146674 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20146674 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20146674 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26352164 — Surrogate Endpoint (SUR): Blood pressure
Study 22025372 — Surrogate Endpoint (SUR): Blood pressure
Study 17492948 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 11499745 — Surrogate Endpoint (SUR): Blood pressure
Study 29504468 — Surrogate Endpoint (SUR): Blood pressure
Study 25709408 — Predictive Biomarker (PRD): Carbonic anhydrase IX
Genes: CA9; G250; MN
Study 23510162 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 16574032 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 2951925 — Surrogate Endpoint (SUR): Blood pressure
Study 17585405 — Surrogate Endpoint (SUR): Blood pressure
Study 16297553 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 16297553 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12066254 — Surrogate Endpoint (SUR): Blood pressure
Study 8749950 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 25740264 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24579364 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Osteopontin
Genes: SPP1; BNSP; OPN; PSEC0156
Study 24579364 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 12456509 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 29710212 — Safety Biomarker (SAF): Hyaluronic acid
Study 20646412 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31809403 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31809403 — Surrogate Endpoint (SUR): Blood pressure
Study 12637460 — Predictive Biomarker (PRD): Hormone receptor
Study 12637460 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 26073878 — Surrogate Endpoint (SUR): Bone mineral density
Study 23224687 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 12562833 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 12562833 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 2865417 — Surrogate Endpoint (SUR): Serum calcium
Study 26847108 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23370085 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3