TrialPanorama/TrialPanorama-database huggingface dataset:
Study 16890574 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 11742191 — Safety Biomarker (SAF): HLA-DRB1
Genes: HLA-DR1B
Study 31037611 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 21691610 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17585313 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 24297940 — Predictive Biomarker (PRD): FLT3 mRNA
Genes: FLT3; CD135; FLK2; STK1
Study 10550151 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 7598070 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31266529 — Predictive Biomarker (PRD): NXF1 mRNA
Genes: NXF1; TAP
Study 23585744 — Surrogate Endpoint (SUR): Blood pressure
Study 23585744 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11176729 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11176729 — Surrogate Endpoint (SUR): Blood pressure
Study 29698447 — Predictive Biomarker (PRD): LOX mRNA
Genes: LOX
Study 29698447 — Surrogate Endpoint (SUR): Blood pressure
Study 23719550 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 23719550 — Surrogate Endpoint (SUR): Blood pressure
Study 17457338 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 1653594 — Surrogate Endpoint (SUR): Blood pressure
Study 24170718 — Predictive Biomarker (PRD): PICALM mRNA
Genes: PICALM; CALM
Study 20961784 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17326029 — Surrogate Endpoint (SUR): Bacterial count
Study 16303295 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 11218985 — Surrogate Endpoint (SUR): Bone mineral density
Study 1315646 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 1315646 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 22607938 — Pharmacodynamic Biomarker (PDY): Human leukocyte antigen DR
Study 25483480 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 24858755 — Surrogate Endpoint (SUR): Probing pocket depth
Study 2320558 — Surrogate Endpoint (SUR): Blood pressure
Study 19716960 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 12231521 — Predictive Biomarker (PRD): KLRK1 mRNA
Genes: KLRK1; D12S2489E; NKG2D
Study 12231521 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 26350766 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 22860014 — Surrogate Endpoint (SUR): Blood pressure
Study 22860014 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19010583 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 11290882 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 11290882 — Predictive Biomarker (PRD): DDC mRNA
Genes: DDC; AADC
Study 11290882 — Surrogate Endpoint (SUR): Blood pressure
Study 28753863 — Surrogate Endpoint (SUR): Serum creatinine
Study 28869786 — Predictive Biomarker (PRD): EBPL mRNA
Genes: EBPL; EBRP; ERP
Study 27278276 — Surrogate Endpoint (SUR): Blood pressure
Study 24342775 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 22321963 — Surrogate Endpoint (SUR): Blood pressure
Study 21194249 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 21194249 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 12682621 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10726921 — Surrogate Endpoint (SUR): Blood pressure
Study 10726921 — Pharmacodynamic Biomarker (PDY): Insulin receptor substrate 1
Genes: IRS1
Study 8934373 — Surrogate Endpoint (SUR): Blood pressure
Study 8934373 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22072154 — Monitoring Biomarker (MOI): HBV DNA
Study 10687258 — Surrogate Endpoint (SUR): Blood pressure
Study 8701872 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9289524 — Predictive Biomarker (PRD): GPT mRNA
Genes: GPT; AAT1; GPT1
Study 9289524 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 9289524 — Surrogate Endpoint (SUR): Blood pressure
Study 24504100 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24504100 — Surrogate Endpoint (SUR): Bone mineral density
Study 24504100 — Predictive Biomarker (PRD): Hormone receptor
Study 22854323 — Surrogate Endpoint (SUR): Serum creatinine
Study 22854323 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 20071999 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 17922014 — Predictive Biomarker (PRD): HMMR mRNA
Genes: HMMR; IHABP; RHAMM
Study 17922014 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 11953279 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 31511080 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 22539172 — Surrogate Endpoint (SUR): Blood pressure
Study 17121868 — Surrogate Endpoint (SUR): Blood pressure
Study 15060873 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15060873 — Surrogate Endpoint (SUR): Serum creatinine
Study 15060873 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 28242866 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 12915429 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12915429 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21896540 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 21896540 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 19399887 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 19399887 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12456429 — Surrogate Endpoint (SUR): Blood pressure
Study 1674835 — Surrogate Endpoint (SUR): Blood pressure
Study 6110504 — Surrogate Endpoint (SUR): Blood pressure
Study 27555505 — Surrogate Endpoint (SUR): Blood pressure
Study 23868103 — Predictive Biomarker (PRD): SHC1 mRNA
Genes: SHC1; SHC; SHCA
Study 11570641 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 8163319 — Surrogate Endpoint (SUR): Blood pressure
Study 29748315 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 30561744 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 25037012 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 19155993 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15744902 — Surrogate Endpoint (SUR): Blood pressure
Study 11991217 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11991217 — Surrogate Endpoint (SUR): Blood pressure
Study 7539853 — Surrogate Endpoint (SUR): Blood pressure
Study 25404569 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19383732 — Surrogate Endpoint (SUR): Blood pressure
Study 11351770 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15296889 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 25348274 — Surrogate Endpoint (SUR): Serum creatinine
Study 19786240 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 16684823 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 9236262 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 8237098 — Surrogate Endpoint (SUR): Blood pressure
Study 3092363 — Surrogate Endpoint (SUR): Blood pressure
Study 21455255 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 24944393 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24944393 — Surrogate Endpoint (SUR): Blood pressure
Study 3125973 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 3125973 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 3125973 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30597771 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 28202779 — Surrogate Endpoint (SUR): Blood pressure
Study 28202779 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28202779 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23036940 — Surrogate Endpoint (SUR): Blood pressure
Study 21625929 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 21625929 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 17022864 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17022864 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17022864 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1395118 — Surrogate Endpoint (SUR): Blood pressure
Study 21194910 — Surrogate Endpoint (SUR): Blood pressure
Study 21194910 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21194910 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 20003299 — Surrogate Endpoint (SUR): Bone mineral density
Study 14605513 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27487914 — Surrogate Endpoint (SUR): Serum creatinine
Study 27487914 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27487914 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27487914 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 22072741 — Surrogate Endpoint (SUR): Bone mineral density
Study 20487050 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29722251 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 19703948 — Safety Biomarker (SAF): Hyaluronic acid
Study 10496523 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 10496523 — Predictive Biomarker (PRD): Microsatellite instability
Study 30760421 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 16296699 — Surrogate Endpoint (SUR): Blood pressure
Study 31154425 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 30010353 — Surrogate Endpoint (SUR): Blood pressure
Study 18318169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28418213 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 25486090 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 21595743 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17242700 — Pharmacodynamic Biomarker (PDY): Retinoblastoma-associated protein
Genes: RB1
Study 9456071 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 1845806 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 29367425 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 29367425 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26901301 — Predictive Biomarker (PRD): VSIR mRNA
Genes: VSIR; C10orf54; SISP1; VISTA; PP2135; UNQ730/PRO1412
Study 26901301 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 22947589 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22947589 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22947589 — Surrogate Endpoint (SUR): Serum calcium
Study 17662632 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17662632 — Surrogate Endpoint (SUR): Bone mineral density
Study 15124669 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7913644 — Surrogate Endpoint (SUR): Blood pressure
Study 1177789 — Surrogate Endpoint (SUR): Blood pressure
Study 31545048 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 25991421 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25991421 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22430457 — Surrogate Endpoint (SUR): Blood pressure
Study 11712773 — Surrogate Endpoint (SUR): Blood pressure
Study 28490230 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 16891861 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 14698782 — Predictive Biomarker (PRD): NE
Study 31943761 — Predictive Biomarker (PRD): EBF1 mRNA
Genes: EBF1; COE1; EBF
Study 24024324 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24024324 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 24024324 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 29054485 — Predictive Biomarker (PRD): SOX2 mRNA
Genes: SOX2
Study 29429593 — Predictive Biomarker (PRD): ARID3B mRNA
Genes: ARID3B; BDP; DRIL2
Study 23835773 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 20205966 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 20205966 — Safety Biomarker (SAF): N-acetylneuraminic acid
Study 18602526 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18602526 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23610856 — Surrogate Endpoint (SUR): Blood pressure
Study 9661603 — Surrogate Endpoint (SUR): Bone mineral density
Study 2699997 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 29534997 — Surrogate Endpoint (SUR): Serum testosterone
Study 26728893 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26728893 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 20215976 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20215976 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10594542 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 30447052 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27468543 — Surrogate Endpoint (SUR): Blood pressure
Study 27468543 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 27468543 — Surrogate Endpoint (SUR): Serum creatinine
Study 24633208 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16534240 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 16534240 — Predictive Biomarker (PRD): POMC mRNA
Genes: POMC
Study 16534240 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 16534240 — Predictive Biomarker (PRD): ENG mRNA
Genes: ENG; END
Study 12011663 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12011663 — Surrogate Endpoint (SUR): Blood pressure
Study 6791673 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 29525393 — Surrogate Endpoint (SUR): Serum calcium
Study 29525393 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 27508314 — Surrogate Endpoint (SUR): Blood pressure
Study 24886036 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 24886036 — Safety Biomarker (SAF): Reactive oxygen species
Study 24886036 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24886036 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 18520951 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18520951 — Surrogate Endpoint (SUR): Blood pressure
Study 15939732 — Surrogate Endpoint (SUR): Forced vital capacity
Study 1658546 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 6127319 — Surrogate Endpoint (SUR): Serum creatinine
Study 31169417 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9141536 — Surrogate Endpoint (SUR): Blood pressure
Study 9141536 — Surrogate Endpoint (SUR): Bone mineral density
Study 7867114 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30408848 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 19803399 — Surrogate Endpoint (SUR): Blood pressure
Study 17488248 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 17488248 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 17488248 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12516788 — Predictive Biomarker (PRD): ADCY10 mRNA
Genes: ADCY10; SAC
Study 9818646 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9818646 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9818646 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 719463 — Surrogate Endpoint (SUR): Blood pressure
Study 16910765 — Predictive Biomarker (PRD): ROS1
Genes: MCF3; ROS; c-ros-1
Study 16910765 — Predictive Biomarker (PRD): NLRP1 mRNA
Genes: NLRP1; CARD7; DEFCAP; KIAA0926; NAC; NALP1
Study 29449080 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18310475 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 16555574 — Surrogate Endpoint (SUR): Serum creatinine
Study 16555574 — Surrogate Endpoint (SUR): Blood pressure
Study 28025862 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28025862 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17239709 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17239709 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 20525993 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 20525993 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 18845704 — Surrogate Endpoint (SUR): Blood pressure
Study 12482789 — Surrogate Endpoint (SUR): Blood pressure
Study 12482789 — Surrogate Endpoint (SUR): Serum sodium
Study 12482789 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20426279 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 9781721 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 3226339 — Surrogate Endpoint (SUR): Serum triglycerides
Study 21439048 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11192518 — Surrogate Endpoint (SUR): Hematologic response
Study 24987174 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 15664480 — Predictive Biomarker (PRD): HTRA3 mRNA
Genes: HTRA3; PRSP
Study 12092689 — Predictive Biomarker (PRD): DPT mRNA
Genes: DPT
Study 10103339 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31714582 — Surrogate Endpoint (SUR): Blood pressure
Study 30646801 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 29146604 — Surrogate Endpoint (SUR): Blood pressure
Study 24148616 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 17122613 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 11420167 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 12959274 — Surrogate Endpoint (SUR): Serum potassium
Study 21869764 — Surrogate Endpoint (SUR): Blood pressure
Study 21869764 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15774905 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31235418 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11703374 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11703374 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 11703374 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 11703374 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 17910747 — Surrogate Endpoint (SUR): Blood pressure
Study 1771173 — Surrogate Endpoint (SUR): Plasma phenylalanine
Study 31693974 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19702643 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 19702643 — Predictive Biomarker (PRD): FGFR3 mRNA
Genes: FGFR3; JTK4
Study 31889507 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29572695 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 24848492 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 24848492 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24848492 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24848492 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15519014 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30029523 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7829764 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 26051569 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 20459634 — Surrogate Endpoint (SUR): Blood pressure
Study 18403102 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12135219 — Predictive Biomarker (PRD): ASRGL1 mRNA
Genes: ASRGL1; ALP; CRASH
Study 12135219 — Surrogate Endpoint (SUR): Bone mineral density
Study 12135219 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 9925060 — Predictive Biomarker (PRD): ARID3B mRNA
Genes: ARID3B; BDP; DRIL2
Study 2180474 — Surrogate Endpoint (SUR): Blood pressure
Study 28763875 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28763875 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol