TrialPanorama/TrialPanorama-database huggingface dataset:
Study 29703633 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24000053 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8141443 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 8141443 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29100829 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 21822144 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 16219327 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 10670394 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 9147709 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 29937273 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 25332468 — Predictive Biomarker (PRD): SERPINA1 mRNA
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209
Study 16749353 — Surrogate Endpoint (SUR): Serum potassium
Study 10489396 — Surrogate Endpoint (SUR): Blood pressure
Study 27658839 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19285200 — Surrogate Endpoint (SUR): Bone mineral density
Study 1534256 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 3884224 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 30394347 — Surrogate Endpoint (SUR): Blood pressure
Study 9692706 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 25496338 — Predictive Biomarker (PRD): GRIK1 mRNA
Genes: GRIK1; GLUR5
Study 17187496 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15713726 — Surrogate Endpoint (SUR): Bone mineral density
Study 1871801 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 6355851 — Surrogate Endpoint (SUR): Blood pressure
Study 28841667 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 28841667 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 25903259 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 25903259 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19776136 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 19776136 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 19776136 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10685992 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 8279224 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30626597 — Surrogate Endpoint (SUR): Blood pressure
Study 31519288 — Surrogate Endpoint (SUR): Blood pressure
Study 23243167 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 8404101 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 8404101 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8404101 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 26285704 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12783234 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 26432671 — Surrogate Endpoint (SUR): Blood pressure
Study 16924007 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 10406828 — Surrogate Endpoint (SUR): Blood pressure
Study 30293332 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30293332 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 3987781 — Surrogate Endpoint (SUR): Blood pressure
Study 30601920 — Predictive Biomarker (PRD): GMCL2 mRNA
Genes: GMCL2; GCL; GMCL1L; GMCL1P1
Study 15631889 — Predictive Biomarker (PRD): ZDHHC8 mRNA
Genes: ZDHHC8; KIAA1292; ZDHHCL1; ZNF378
Study 10490854 — Predictive Biomarker (PRD): FXYD1 mRNA
Genes: FXYD1; PLM
Study 20605840 — Safety Biomarker (SAF): Connecting peptide
Genes: AHSG; FETUA; PRO2743
Study 11233547 — Predictive Biomarker (PRD): SLN mRNA
Genes: SLN
Study 26846078 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26846078 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26846078 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 12883972 — Surrogate Endpoint (SUR): Bone mineral density
Study 3541623 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3541623 — Surrogate Endpoint (SUR): Serum triglycerides
Study 3541623 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23953553 — Surrogate Endpoint (SUR): Serum creatinine
Study 31724337 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 31724337 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30396363 — Surrogate Endpoint (SUR): Blood pressure
Study 23114104 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19874329 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17585215 — Surrogate Endpoint (SUR): Blood pressure
Study 10930636 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 4025773 — Surrogate Endpoint (SUR): Blood pressure
Study 27769202 — Predictive Biomarker (PRD): LTB4R mRNA
Genes: LTB4R; BLT; BLT1; BLTR; CMKRL1; GPR16; P2RY7
Study 11063182 — Surrogate Endpoint (SUR): Blood pressure
Study 28404197 — Safety Biomarker (SAF): Thiopurine S-methyltransferase
Genes: TPMT
Study 25022690 — Safety Biomarker (SAF): Reactive oxygen species
Study 10232413 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 8912740 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 15337326 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 9686768 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 29722110 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 29722110 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 14644865 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9209244 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 8260476 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 2893564 — Surrogate Endpoint (SUR): Blood pressure
Study 22374331 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 22374331 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 22374331 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 22374331 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 12464992 — Surrogate Endpoint (SUR): Blood pressure
Study 10657735 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 2173282 — Predictive Biomarker (PRD): ADCY10 mRNA
Genes: ADCY10; SAC
Study 28086896 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19265046 — Surrogate Endpoint (SUR): Blood pressure
Study 12728284 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28847198 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 28847198 — Predictive Biomarker (PRD): LDLR mRNA
Genes: LDLR
Study 28847198 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28847198 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 28847198 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28847198 — Safety Biomarker (SAF): Interleukin 1
Study 12615625 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 29915617 — Surrogate Endpoint (SUR): Blood pressure
Study 26894924 — Surrogate Endpoint (SUR): Serum creatinine
Study 24935613 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8578093 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23045591 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 23045591 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 23045591 — Predictive Biomarker (PRD): NDRG1 mRNA
Genes: NDRG1; CAP43; DRG1; RTP
Study 23045591 — Predictive Biomarker (PRD): SLC7A5 mRNA
Genes: SLC7A5; CD98LC; LAT1; MPE16
Study 23045591 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 16055868 — Surrogate Endpoint (SUR): Forced vital capacity
Study 8006330 — Predictive Biomarker (PRD): ABL2 mRNA
Genes: ABL2; ABLL; ARG
Study 1101909 — Predictive Biomarker (PRD): EDAR mRNA
Genes: EDAR; DL
Study 23668772 — Surrogate Endpoint (SUR): Blood pressure
Study 14627528 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 7489421 — Surrogate Endpoint (SUR): Blood pressure
Study 18295467 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 18295467 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17201084 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 30497484 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 21793327 — Surrogate Endpoint (SUR): Blood pressure
Study 10973651 — Surrogate Endpoint (SUR): Bone mineral density
Study 31321951 — Predictive Biomarker (PRD): F7 mRNA
Genes: F7
Study 31321951 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 10370741 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 7526483 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 31809866 — Surrogate Endpoint (SUR): Bone mineral density
Study 28573374 — Predictive Biomarker (PRD): TRPV1 mRNA
Genes: TRPV1; VR1
Study 28573374 — Predictive Biomarker (PRD): TRPA1 mRNA
Genes: TRPA1; ANKTM1
Study 25912697 — Surrogate Endpoint (SUR): Blood pressure
Study 10979055 — Surrogate Endpoint (SUR): Blood pressure
Study 10979055 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1397666 — Surrogate Endpoint (SUR): Blood pressure
Study 18047870 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 31931977 — Surrogate Endpoint (SUR): Blood pressure
Study 25117817 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 22300946 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 22300946 — Safety Biomarker (SAF): Cytochrome c
Study 2097777 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2097777 — Surrogate Endpoint (SUR): Blood pressure
Study 31196453 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31196453 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31196453 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25663767 — Predictive Biomarker (PRD): CD44 mRNA
Genes: CD44; LHR; MDU2; MDU3; MIC4
Study 25663767 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 19494217 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19494217 — Safety Biomarker (SAF): Interleukin 1
Study 15121733 — Surrogate Endpoint (SUR): Bone mineral density
Study 11436644 — Monitoring Biomarker (MOI): HBV DNA
Study 31558480 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 31558480 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Tumor mutational burden
Study 27459375 — Surrogate Endpoint (SUR): Blood pressure
Study 23753094 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 18543304 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15718847 — Surrogate Endpoint (SUR): Bone mineral density
Study 24472402 — Predictive Biomarker (PRD): TRPV1 mRNA
Genes: TRPV1; VR1
Study 22820409 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19563331 — Surrogate Endpoint (SUR): Probing pocket depth
Study 9891541 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 15068851 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15068851 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 9699891 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 7916278 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 31932513 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 31932513 — Safety Biomarker (SAF): MTHFR
Study 26550817 — Safety Biomarker (SAF): Hyaluronic acid
Study 15023883 — Surrogate Endpoint (SUR): Blood pressure
Study 15023883 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 8390508 — Surrogate Endpoint (SUR): Blood pressure
Study 24660827 — Predictive Biomarker (PRD): BAK1 mRNA
Genes: BAK1; BAK; BCL2L7; CDN1
Study 22726593 — Predictive Biomarker (PRD): TLR7 mRNA
Genes: TLR7; UNQ248/PRO285
Study 22726593 — Safety Biomarker (SAF): Interleukin 1
Study 20147603 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18305126 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 18305126 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 18305126 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 14738561 — Monitoring Biomarker (MOI): HBV DNA
Study 17215186 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 9306087 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 30033064 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30033064 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27813617 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 18922386 — Safety Biomarker (SAF): Reactive oxygen species
Study 18922386 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10363425 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9331518 — Surrogate Endpoint (SUR): Blood pressure
Study 19006027 — Surrogate Endpoint (SUR): Serum creatinine
Study 8592096 — Surrogate Endpoint (SUR): Serum potassium
Study 8592096 — Surrogate Endpoint (SUR): Blood pressure
Study 6362341 — Surrogate Endpoint (SUR): Blood pressure
Study 22799482 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22799482 — Surrogate Endpoint (SUR): Blood pressure
Study 14623837 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 27075863 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27075863 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25312202 — Predictive Biomarker (PRD): GSR mRNA
Genes: GSR; GLUR; GRD1
Study 22460469 — Surrogate Endpoint (SUR): Bone mineral density
Study 19676097 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): FKBP5 mRNA
Genes: FKBP5; AIG6; FKBP51
Study 11320545 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 8203337 — Surrogate Endpoint (SUR): Blood pressure
Study 8203337 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3555588 — Surrogate Endpoint (SUR): Blood pressure
Study 25799402 — Surrogate Endpoint (SUR): Bone mineral density
Study 15763649 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 15763649 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 21291323 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21291323 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 7890436 — Safety Biomarker (SAF): Interleukin 1
Study 3371085 — Surrogate Endpoint (SUR): Blood pressure
Study 28777242 — Predictive Biomarker (PRD): NR1I2 mRNA
Genes: NR1I2; PXR
Study 28777242 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 28777242 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 26033349 — Surrogate Endpoint (SUR): Blood pressure
Study 21744191 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16778714 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 11781651 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21733061 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 1607582 — Predictive Biomarker (PRD): CAST mRNA
Genes: CAST
Study 21641362 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 21641362 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11224578 — Surrogate Endpoint (SUR): Serum calcium
Study 9143000 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 8204806 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 18467909 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 11753266 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 29562041 — Surrogate Endpoint (SUR): Blood pressure
Study 19293667 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19293667 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 19293667 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17108825 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17976228 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 17976228 — Surrogate Endpoint (SUR): Blood pressure
Study 28857839 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 1442760 — Surrogate Endpoint (SUR): Blood pressure
Study 30587335 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 229146 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 28706955 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 23984352 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 20189663 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16505423 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 14764220 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27504605 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27504605 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27504605 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25310116 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10077358 — Surrogate Endpoint (SUR): Serum testosterone
Study 25429550 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 23328954 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 23328954 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 15001463 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 3049266 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 12172218 — Predictive Biomarker (PRD): GNB3 mRNA
Genes: GNB3
Study 12172218 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 18343247 — Surrogate Endpoint (SUR): Blood pressure
Study 15969882 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 27658693 — Monitoring Biomarker (MOI): HBV DNA
Study 22589472 — Predictive Biomarker (PRD): Liver iron
Study 20697801 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 20697801 — Predictive Biomarker (PRD): Hormone receptor
Study 17663731 — Surrogate Endpoint (SUR): Bone mineral density
Study 2181991 — Monitoring Biomarker (MOI): HBV DNA
Study 16710614 — Surrogate Endpoint (SUR): Blood pressure
Study 8420065 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 8420065 — Surrogate Endpoint (SUR): Serum creatinine
Study 27678439 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30882596 — Surrogate Endpoint (SUR): Blood pressure
Study 23298824 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20734049 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 17142138 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17142138 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17142138 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8287662 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30747566 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 25488849 — Surrogate Endpoint (SUR): Forced vital capacity
Study 14569096 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 14569096 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 14569096 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 10777036 — Surrogate Endpoint (SUR): Blood pressure
Study 31070471 — Predictive Biomarker (PRD): PLA2G2A mRNA
Genes: PLA2G2A; PLA2B; PLA2L; RASF-A
Study 23958407 — Surrogate Endpoint (SUR): Blood pressure
Study 23958407 — Surrogate Endpoint (SUR): Serum triglycerides
Study 21752880 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21752880 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol