TrialPanorama/TrialPanorama-database huggingface dataset:
Study 21827635 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 15292287 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 16791444 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12442345 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19179203 — Surrogate Endpoint (SUR): Blood pressure
Study 19179203 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21796123 — Surrogate Endpoint (SUR): Blood pressure
Study 8257455 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 8257455 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 31381021 — Predictive Biomarker (PRD): RANGAP1 mRNA
Genes: RANGAP1; KIAA1835; SD
Study 28560853 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 21300516 — Surrogate Endpoint (SUR): Blood pressure
Study 21300516 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16858181 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Albumin mRNA
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 12853996 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 22422082 — Surrogate Endpoint (SUR): Probing pocket depth
Study 15359983 — Surrogate Endpoint (SUR): Serum creatinine
Study 9796073 — Surrogate Endpoint (SUR): Blood pressure
Study 23382157 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 19407947 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 28163248 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 23239683 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18227852 — Surrogate Endpoint (SUR): Forced vital capacity
Study 11092294 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 2553511 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30317839 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30317839 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 1827003 — Surrogate Endpoint (SUR): Blood pressure
Study 30381412 — Surrogate Endpoint (SUR): Serum potassium
Study 30381412 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 30381412 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 30381412 — Surrogate Endpoint (SUR): Serum calcium
Study 28984632 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 28984632 — Safety Biomarker (SAF): Reactive oxygen species
Study 15569835 — Surrogate Endpoint (SUR): Blood pressure
Study 15569835 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 28667579 — Surrogate Endpoint (SUR): Serum calcium
Study 28667579 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26126970 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23444963 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19173710 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 19173710 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27400316 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 19618992 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19618992 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9700881 — Predictive Biomarker (PRD): CD72 mRNA
Genes: CD72
Study 9700881 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 24378599 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9650682 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 8135428 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 31015261 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25620313 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 17547798 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17547798 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17547798 — Surrogate Endpoint (SUR): Serum triglycerides
Study 15337732 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3294285 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31665619 — Safety Biomarker (SAF): BDNF
Study 23919955 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 8887015 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29526860 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 10621930 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8637188 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8637188 — Surrogate Endpoint (SUR): Blood pressure
Study 28137754 — Predictive Biomarker (PRD): POR mRNA
Genes: POR; CYPOR
Study 28137754 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 22242343 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19822956 — Predictive Biomarker (PRD): SLC2A1 mRNA
Genes: SLC2A1; GLUT1
Study 30661477 — Surrogate Endpoint (SUR): Blood pressure
Study 17917992 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 9552221 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 19951554 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15199365 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 729619 — Surrogate Endpoint (SUR): Blood pressure
Study 26347398 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 19111408 — Predictive Biomarker (PRD); Safety Biomarker (SAF): ESR2 mRNA
Genes: ESR2; ESTRB; NR3A2
Study 19111408 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15310737 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9695137 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 9893070 — Surrogate Endpoint (SUR): Bone mineral density
Study 21551507 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19958629 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 9505774 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 8541002 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8541002 — Surrogate Endpoint (SUR): Blood pressure
Study 8541002 — Surrogate Endpoint (SUR): Serum creatinine
Study 31957666 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31957666 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 31708410 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31708410 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26004431 — Safety Biomarker (SAF): MATE1
Genes: SLC47A1; FLJ10847
Study 26004431 — Predictive Biomarker (PRD): SLC47A1 mRNA
Genes: SLC47A1; MATE1
Study 29588232 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29588232 — Surrogate Endpoint (SUR): Blood pressure
Study 21038650 — Monitoring Biomarker (MOI): HBV DNA
Study 21038650 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 21038650 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 19066345 — Surrogate Endpoint (SUR): Blood pressure
Study 7596125 — Surrogate Endpoint (SUR): Blood pressure
Study 31063 — Surrogate Endpoint (SUR): Blood pressure
Study 24600204 — Surrogate Endpoint (SUR): Blood pressure
Study 22257505 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 22257505 — Surrogate Endpoint (SUR): Forced vital capacity
Study 15993359 — Predictive Biomarker (PRD): GAD2 mRNA
Genes: GAD2; GAD65
Study 15993359 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15993359 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 11485375 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 9988537 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 26460291 — Surrogate Endpoint (SUR): Blood pressure
Study 19363330 — Surrogate Endpoint (SUR): Bone mineral density
Study 3211079 — Surrogate Endpoint (SUR): Blood pressure
Study 20979799 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12461499 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31544378 — Predictive Biomarker (PRD): OCA2 mRNA
Genes: OCA2; D15S12; P
Study 24777811 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24777811 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 24777811 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 24659566 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 8677931 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 6121479 — Surrogate Endpoint (SUR): Blood pressure
Study 27550386 — Surrogate Endpoint (SUR): Blood pressure
Study 25720388 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 17520986 — Surrogate Endpoint (SUR): Blood pressure
Study 12368393 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 21214718 — Surrogate Endpoint (SUR): Blood pressure
Study 21214718 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 12924169 — Surrogate Endpoint (SUR): Serum uric acid
Study 3838625 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 3838625 — Predictive Biomarker (PRD): FMN1 mRNA
Genes: FMN1; FMN; LD
Study 3838625 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 31870634 — Surrogate Endpoint (SUR): Bone mineral density
Study 16051882 — Predictive Biomarker (PRD): ALDH2 mRNA
Genes: ALDH2; ALDM
Study 10404451 — Surrogate Endpoint (SUR): Serum creatinine
Study 6798382 — Surrogate Endpoint (SUR): Blood pressure
Study 27664002 — Surrogate Endpoint (SUR): Blood pressure
Study 21057005 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30
Study 15045594 — Surrogate Endpoint (SUR): Blood pressure
Study 31008935 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 31008935 — Surrogate Endpoint (SUR): Blood pressure
Study 27376418 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 27376418 — Predictive Biomarker (PRD): HGS mRNA
Genes: HGS; HRS
Study 21839414 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 19810001 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 15231444 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 3028457 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27027897 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27027897 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16169328 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8974970 — Surrogate Endpoint (SUR): Blood pressure
Study 19198268 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 15637467 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 15637467 — Safety Biomarker (SAF): Urinary microalbumin
Study 10708814 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 6873137 — Surrogate Endpoint (SUR): Blood pressure
Study 22313885 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31860537 — Surrogate Endpoint (SUR): Serum calcium
Study 16105869 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 16105869 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21168112 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 12381902 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 8524988 — Surrogate Endpoint (SUR): Blood pressure
Study 2177158 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 2177158 — Pharmacodynamic Biomarker (PDY): Mismatch negativity
Study 20922557 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 11052308 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 11052308 — Predictive Biomarker (PRD): NTM mRNA
Genes: NTM; IGLON2; NT; UNQ297/PRO337
Study 18786318 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14703408 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 9295106 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 7956624 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 31051506 — Surrogate Endpoint (SUR): Blood pressure
Study 30247596 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30247596 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 30247596 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 21456104 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 25125505 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 25125505 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22913248 — Surrogate Endpoint (SUR): Blood pressure
Study 22913248 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16140428 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11947910 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27718765 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 27718765 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27718765 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 27718765 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 27718765 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 3720176 — Surrogate Endpoint (SUR): Blood pressure
Study 28631582 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 23515614 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 10978398 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 31483910 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31483910 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31483910 — Predictive Biomarker (PRD): ATF4 mRNA
Genes: ATF4; CREB2; TXREB
Study 31483910 — Predictive Biomarker (PRD): ATF6 mRNA
Genes: ATF6
Study 31483910 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 31483910 — Predictive Biomarker (PRD): HSPA5 mRNA
Genes: HSPA5; GRP78
Study 31483910 — Predictive Biomarker (PRD): XBP1 mRNA
Genes: XBP1; TREB5; XBP2
Study 26290682 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 18400716 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10409200 — Surrogate Endpoint (SUR): Blood pressure
Study 29469046 — Surrogate Endpoint (SUR): Serum creatinine
Study 16197659 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16197659 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11998963 — Surrogate Endpoint (SUR): Serum triglycerides
Study 28427806 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24598948 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 21609527 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 24911964 — Surrogate Endpoint (SUR): Blood pressure
Study 10500826 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 10500826 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 23570538 — Predictive Biomarker (PRD): SH2D1A mRNA
Genes: SH2D1A; DSHP; SAP
Study 9232210 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 9232210 — Surrogate Endpoint (SUR): Blood pressure
Study 3434164 — Surrogate Endpoint (SUR): Blood pressure
Study 19910076 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 18403492 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 11022366 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9620526 — Surrogate Endpoint (SUR): Blood pressure
Study 25713659 — Surrogate Endpoint (SUR): Blood pressure
Study 19734132 — Surrogate Endpoint (SUR): Bone mineral density
Study 10319358 — Predictive Biomarker (PRD): C6orf15 mRNA
Genes: C6orf15; STG; UNQ1840/PRO3566
Study 8733039 — Surrogate Endpoint (SUR): Blood pressure
Study 28710205 — Surrogate Endpoint (SUR): Blood pressure
Study 1824760 — Surrogate Endpoint (SUR): Blood pressure
Study 29985223 — Predictive Biomarker (PRD): HHEX mRNA
Genes: HHEX; HEX; PRH; PRHX
Study 30552239 — Surrogate Endpoint (SUR): Blood pressure
Study 16419643 — Surrogate Endpoint (SUR): Blood pressure
Study 8877666 — Surrogate Endpoint (SUR): Probing pocket depth
Study 30873657 — Predictive Biomarker (PRD): PMM2 mRNA
Genes: PMM2
Study 25520340 — Surrogate Endpoint (SUR): Bone mineral density
Study 31743554 — Predictive Biomarker (PRD): INVS mRNA
Genes: INVS; INV; NPHP2
Study 31743554 — Pharmacodynamic Biomarker (PDY): Lysosomal acid glucosylceramidase
Genes: GBA1; GBA; GC; GLUC
Study 31743554 — Predictive Biomarker (PRD): AQP3 mRNA
Genes: AQP3
Study 31743554 — Predictive Biomarker (PRD): ELOVL3 mRNA
Genes: ELOVL3; CIG30
Study 23602291 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 19008718 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 19008718 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19008718 — Surrogate Endpoint (SUR): Blood pressure
Study 19008718 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19008718 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19008718 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12919430 — Predictive Biomarker (PRD): AMT mRNA
Genes: AMT; GCST
Study 12919430 — Surrogate Endpoint (SUR): Blood pressure
Study 9322471 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8139175 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8139175 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30856182 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 27228651 — Predictive Biomarker (PRD): COMP mRNA
Genes: COMP
Study 27228651 — Safety Biomarker (SAF): Myeloperoxidase
Genes: MPO
Study 27228651 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25122648 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 21531577 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 15542572 — Surrogate Endpoint (SUR): Blood pressure
Study 2170852 — Surrogate Endpoint (SUR): Blood pressure
Study 22393084 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 17936185 — Safety Biomarker (SAF): Coagulation factor IIa
Genes: F2
Study 15009332 — Surrogate Endpoint (SUR): Blood pressure
Study 9853647 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 22112605 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17389554 — Surrogate Endpoint (SUR): Blood pressure
Study 11826641 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17251482 — Surrogate Endpoint (SUR): Blood pressure
Study 9562938 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7698127 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7698127 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22465206 — Surrogate Endpoint (SUR): Blood pressure
Study 22013794 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 19079839 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 19079839 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16697324 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 16091234 — Predictive Biomarker (PRD): DSP mRNA
Genes: DSP
Study 11306776 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 2573325 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 2573325 — Surrogate Endpoint (SUR): Blood pressure
Study 239414 — Surrogate Endpoint (SUR): Blood pressure
Study 25361548 — Pharmacodynamic Biomarker (PDY): Gamma-Histone H2AX
Genes: H2AX; H2AFX
Study 19906002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19906002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19906002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21057560 — Predictive Biomarker (PRD): HMMR mRNA
Genes: HMMR; IHABP; RHAMM
Study 11676153 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 14628495 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11140558 — Surrogate Endpoint (SUR): Probing pocket depth
Study 9167457 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1