TrialPanorama/TrialPanorama-database huggingface dataset:
Study 21161265 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21161265 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21161265 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 21161265 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 21161265 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 21161265 — Safety Biomarker (SAF): Interleukin 12
Study 31656059 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 6382224 — Surrogate Endpoint (SUR): Blood pressure
Study 15951292 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 2939008 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24794880 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 7671159 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 7671159 — Surrogate Endpoint (SUR): Bone mineral density
Study 7671159 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 7671159 — Surrogate Endpoint (SUR): Serum calcium
Study 31917283 — Predictive Biomarker (PRD): AGER mRNA
Genes: AGER; RAGE
Study 31917283 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 31917283 — Predictive Biomarker (PRD): ADIPOQ mRNA
Genes: ADIPOQ; ACDC; ACRP30; APM1; GBP28
Study 31917283 — Surrogate Endpoint (SUR): Blood pressure
Study 15241356 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 15241356 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12618057 — Surrogate Endpoint (SUR): Blood pressure
Study 31001673 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31001673 — Predictive Biomarker (PRD): TNFRSF1A mRNA
Genes: TNFRSF1A; TNFAR; TNFR1
Study 31001673 — Predictive Biomarker (PRD): MMP7 mRNA
Genes: MMP7; MPSL1; PUMP1
Study 31001673 — Predictive Biomarker (PRD): FN1 mRNA
Genes: FN1; FN
Study 26990931 — Predictive Biomarker (PRD): NPL mRNA
Genes: NPL; C1orf13
Study 26990931 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 26990931 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 23834392 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23834392 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 7986464 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 2723246 — Surrogate Endpoint (SUR): Blood pressure
Study 31876900 — Pharmacodynamic Biomarker (PDY): Antidrug antibody
Study 17077073 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 17077073 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11500188 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11500188 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 11500188 — Surrogate Endpoint (SUR): Serum triglycerides
Study 26063762 — Surrogate Endpoint (SUR): Blood pressure
Study 21929518 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 17660871 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 8596749 — Surrogate Endpoint (SUR): Serum testosterone
Study 25787895 — Predictive Biomarker (PRD): Glutamate carboxypeptidase II
Genes: FOLH1; FOLH; NAALAD1; PSM; PSMA; GIG27
Study 21827648 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 14517190 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 9195351 — Surrogate Endpoint (SUR): Blood pressure
Study 23058022 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 19534034 — Surrogate Endpoint (SUR): Blood pressure
Study 17300595 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 11142674 — Surrogate Endpoint (SUR): Probing pocket depth
Study 15280526 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 31537527 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 31537527 — Pharmacodynamic Biomarker (PDY): Stromal cell-derived factor 1
Genes: CXCL12; SDF1; SDF1A; SDF1B
Study 27358154 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19204077 — Surrogate Endpoint (SUR): Blood pressure
Study 17949325 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 1854464 — Surrogate Endpoint (SUR): Blood pressure
Study 28877011 — Predictive Biomarker (PRD): TSLP mRNA
Genes: TSLP
Study 19339704 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 8384171 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 26913388 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 22420492 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 12577433 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12577433 — Safety Biomarker (SAF): Interleukin 1
Study 25922285 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 19590447 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15538041 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 15538041 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 15538041 — Predictive Biomarker (PRD): Hormone receptor
Study 15538041 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1617510 — Surrogate Endpoint (SUR): Blood pressure
Study 1617510 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1617510 — Surrogate Endpoint (SUR): Serum triglycerides
Study 29390862 — Surrogate Endpoint (SUR): Blood pressure
Study 8709585 — Predictive Biomarker (PRD): ALDH2 mRNA
Genes: ALDH2; ALDM
Study 3892220 — Surrogate Endpoint (SUR): Serum creatinine
Study 1386223 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 30850442 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 25547219 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 16237394 — Predictive Biomarker (PRD): DRD4 mRNA
Genes: DRD4
Study 18024231 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18024231 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12812378 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24082728 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24082728 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24082728 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12959631 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28937828 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 28937828 — Predictive Biomarker (PRD): TH mRNA
Genes: TH; TYH
Study 28937828 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 14872155 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28343225 — Surrogate Endpoint (SUR): Blood pressure
Study 28343225 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 28343225 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26304864 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 8706772 — Surrogate Endpoint (SUR): Blood pressure
Study 6143667 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 6143667 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 6143667 — Surrogate Endpoint (SUR): Blood pressure
Study 25041182 — Surrogate Endpoint (SUR): Probing pocket depth
Study 25041182 — Monitoring Biomarker (MOI): Matrix metalloproteinase 8
Genes: MMP8; CLG1
Study 21153418 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21153418 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 23614336 — Surrogate Endpoint (SUR): Blood pressure
Study 17413098 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 3330992 — Surrogate Endpoint (SUR): Blood pressure
Study 27317632 — Surrogate Endpoint (SUR): Blood pressure
Study 20889295 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 9454352 — Safety Biomarker (SAF): Argininosuccinate synthase
Genes: ASS1; ASS
Study 29769507 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22037055 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 10709884 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 12399266 — Surrogate Endpoint (SUR): Blood pressure
Study 6270809 — Surrogate Endpoint (SUR): Blood pressure
Study 24157401 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 31736406 — Surrogate Endpoint (SUR): Blood pressure
Study 28458115 — Predictive Biomarker (PRD): MAP2 mRNA
Genes: MAP2
Study 30326124 — Surrogate Endpoint (SUR): Forced vital capacity
Study 25622742 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16928705 — Surrogate Endpoint (SUR): Blood pressure
Study 15219522 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15219522 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30642737 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30642737 — Surrogate Endpoint (SUR): Serum triglycerides
Study 21999374 — Predictive Biomarker (PRD): PYCARD mRNA
Genes: PYCARD; ASC; CARD5; TMS1
Study 21999374 — Predictive Biomarker (PRD): GAL3ST1 mRNA
Genes: GAL3ST1; CST
Study 17130417 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 15276488 — Surrogate Endpoint (SUR): Forced vital capacity
Study 8305165 — Surrogate Endpoint (SUR): Blood pressure
Study 3545647 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 3545647 — Surrogate Endpoint (SUR): Blood pressure
Study 17175645 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 17175645 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 11353932 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 11353932 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 11353932 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 15302981 — Surrogate Endpoint (SUR): Blood pressure
Study 15302981 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9834279 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23182627 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 16836917 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 16836917 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 9030681 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 9030681 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 8301102 — Surrogate Endpoint (SUR): Blood pressure
Study 24831979 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 10682566 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 26954978 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26954978 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19487105 — Surrogate Endpoint (SUR): Blood pressure
Study 8698447 — Surrogate Endpoint (SUR): Blood pressure
Study 30528686 — Predictive Biomarker (PRD): MVP mRNA
Genes: MVP; LRP
Study 1704989 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 1704989 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 1704989 — Surrogate Endpoint (SUR): Blood pressure
Study 28455996 — Surrogate Endpoint (SUR): Serum creatinine
Study 28455996 — Surrogate Endpoint (SUR): Blood pressure
Study 28455996 — Surrogate Endpoint (SUR): Serum potassium
Study 25826479 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 20008236 — Predictive Biomarker (PRD): HES1 mRNA
Genes: HES1; BHLHB39; HL; HRY
Study 16973256 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 16973256 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 2969320 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 2969320 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 2969320 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2969320 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27016296 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 20437326 — Predictive Biomarker (PRD): GAL3ST1 mRNA
Genes: GAL3ST1; CST
Study 10943871 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10943871 — Surrogate Endpoint (SUR): Serum creatinine
Study 9116921 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 19358978 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 9136830 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 28275109 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 28275109 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 27284930 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 24752831 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8133536 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 26940016 — Predictive Biomarker (PRD): SQSTM1 mRNA
Genes: SQSTM1; ORCA; OSIL
Study 26940016 — Predictive Biomarker (PRD): TLR2 mRNA
Genes: TLR2; TIL4
Study 26940016 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 26940016 — Predictive Biomarker (PRD): TICAM1 mRNA
Genes: TICAM1; PRVTIRB; TRIF
Study 20179636 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1839437 — Surrogate Endpoint (SUR): Blood pressure
Study 17096182 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 17096182 — Surrogate Endpoint (SUR): Forced vital capacity
Study 11699068 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11699068 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30958325 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 11733289 — Surrogate Endpoint (SUR): Blood pressure
Study 9164221 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 8425987 — Surrogate Endpoint (SUR): Blood pressure
Study 23152373 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16886238 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 11723016 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 11723016 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 11723016 — Safety Biomarker (SAF): Coagulation factor Va
Genes: F5
Study 8253932 — Surrogate Endpoint (SUR): Sperm parameters
Study 29699816 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 29699816 — Predictive Biomarker (PRD): LIPC mRNA
Genes: LIPC; HTGL
Study 29699816 — Predictive Biomarker (PRD): FADS2 mRNA
Genes: FADS2
Study 29699816 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27524193 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 23729106 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Lung surfactant protein D
Genes: SFTPD; COLEC7; PSPD; SFTP4
Study 10372705 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10372705 — Surrogate Endpoint (SUR): Serum triglycerides
Study 17521243 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 15186950 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 2764533 — Predictive Biomarker (PRD): CPZ mRNA
Genes: CPZ
Study 17320192 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 7524278 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 3063290 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 3063290 — Surrogate Endpoint (SUR): Blood pressure
Study 3063290 — Surrogate Endpoint (SUR): Serum calcium
Study 31121100 — Surrogate Endpoint (SUR): Blood pressure
Study 31121100 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29233906 — Predictive Biomarker (PRD): AKT1 mRNA
Genes: AKT1; PKB; RAC
Study 21235416 — Surrogate Endpoint (SUR): Blood pressure
Study 31873085 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 31873085 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 31873085 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 27585503 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31204532 — Predictive Biomarker (PRD): ABO mRNA
Genes: ABO
Study 30077185 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 10367032 — Surrogate Endpoint (SUR): Bone mineral density
Study 10367032 — Surrogate Endpoint (SUR): Serum calcium
Study 7547096 — Surrogate Endpoint (SUR): Blood pressure
Study 24074269 — Surrogate Endpoint (SUR): Blood pressure
Study 10390399 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29510792 — Surrogate Endpoint (SUR): Blood pressure
Study 24576868 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12200905 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21884018 — Predictive Biomarker (PRD): KCNN1 mRNA
Genes: KCNN1; SK
Study 15699486 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2558622 — Surrogate Endpoint (SUR): Blood pressure
Study 18642654 — Predictive Biomarker (PRD): NF2 mRNA
Genes: NF2; SCH
Study 9026268 — Surrogate Endpoint (SUR): Bone mineral density
Study 1395074 — Surrogate Endpoint (SUR): Blood pressure
Study 30598484 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24942540 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31150799 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30177026 — Predictive Biomarker (PRD): TCF7L2 mRNA
Genes: TCF7L2; TCF4
Study 25424924 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 25424924 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23163141 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23163141 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15583361 — Surrogate Endpoint (SUR): Blood pressure
Study 10743482 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17686445 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 17686445 — Predictive Biomarker (PRD): DNA excision repair protein ERCC-1
Genes: ERCC1
Study 17686445 — Predictive Biomarker (PRD): Ribonucleoside-diphosphate reductase large subunit
Genes: RRM1; RR1
Study 17686445 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 17686445 — Predictive Biomarker (PRD): XRCC3 mRNA
Genes: XRCC3
Study 15848611 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 15848611 — Surrogate Endpoint (SUR): Bone mineral density
Study 28589217 — Surrogate Endpoint (SUR): Serum creatinine
Study 9062473 — Surrogate Endpoint (SUR): Blood pressure
Study 7691256 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 26315844 — Predictive Biomarker (PRD): PNPLA3 mRNA
Genes: PNPLA3; ADPN; C22orf20
Study 15956998 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 28566591 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28566591 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 28566591 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 25118156 — Predictive Biomarker (PRD): FST mRNA
Genes: FST
Study 15129422 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 15129422 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 9515532 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 9515532 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9515532 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 3123117 — Surrogate Endpoint (SUR): Serum calcium
Study 25658881 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11078261 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 10643696 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 29045255 — Surrogate Endpoint (SUR): Blood pressure
Study 20210909 — Surrogate Endpoint (SUR): Bone mineral density
Study 29770393 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 27127346 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 22409423 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 17503687 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 28636184 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 28636184 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16818923 — Surrogate Endpoint (SUR): Blood pressure
Study 16818923 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16818923 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1