TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23441533 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20212395 — Surrogate Endpoint (SUR): Blood pressure
Study 18411237 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 12552209 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TNS1 mRNA
Genes: TNS1; TNS
Study 30962499 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30962499 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11282752 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 21804670 — Surrogate Endpoint (SUR): Blood pressure
Study 29421772 — Safety Biomarker (SAF): Interleukin 1
Study 29421772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29421772 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23773411 — Predictive Biomarker (PRD): Carbonic anhydrase IX
Genes: CA9; G250; MN
Study 11532470 — Predictive Biomarker (PRD): DAZ1 mRNA
Genes: DAZ1; DAZ; SPGY
Study 3413461 — Surrogate Endpoint (SUR): Blood pressure
Study 28441068 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 20616787 — Surrogate Endpoint (SUR): Blood pressure
Study 18221288 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 10925662 — Predictive Biomarker (PRD): EHF mRNA
Genes: EHF; ESE3; ESE3B; ESEJ
Study 14621839 — Surrogate Endpoint (SUR): Serum creatinine
Study 22818724 — Surrogate Endpoint (SUR): Blood pressure
Study 20571361 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 12000000 — Surrogate Endpoint (SUR): Urine free cortisol
Study 25832102 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 22457418 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 22457418 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22457418 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 22457418 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26139105 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 22009540 — Surrogate Endpoint (SUR): Serum creatinine
Study 23408048 — Predictive Biomarker (PRD): HBE1 mRNA
Genes: HBE1; HBE
Study 21247247 — Surrogate Endpoint (SUR): Blood pressure
Study 19409533 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17701889 — Predictive Biomarker (PRD): ABCC8 mRNA
Genes: ABCC8; HRINS; SUR; SUR1
Study 9859964 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30886326 — Surrogate Endpoint (SUR): Blood pressure
Study 17370485 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 27397060 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 11566625 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 11566625 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 8311557 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8311557 — Surrogate Endpoint (SUR): Bone mineral density
Study 28208713 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28208713 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28208713 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 28208713 — Predictive Biomarker (PRD): PMVK mRNA
Genes: PMVK; PMKI
Study 28208713 — Predictive Biomarker (PRD): ZFAND5 mRNA
Genes: ZFAND5; ZA20D2; ZNF216
Study 28208713 — Predictive Biomarker (PRD): CAB39 mRNA
Genes: CAB39; MO25; CGI-66
Study 28208713 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14746858 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 11008916 — Predictive Biomarker (PRD): MYCN mRNA
Genes: MYCN; BHLHE37; NMYC
Study 9239165 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 8444218 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 20738307 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 20738307 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 20738307 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 19064019 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9040899 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 22681971 — Surrogate Endpoint (SUR): Blood pressure
Study 20921442 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 20921442 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20921442 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 20921442 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9643273 — Surrogate Endpoint (SUR): Blood pressure
Study 28275131 — Predictive Biomarker (PRD): CIT mRNA
Genes: CIT; CRIK; KIAA0949; STK21
Study 25541647 — Predictive Biomarker (PRD): PEAR1 mRNA
Genes: PEAR1; MEGF12
Study 25541647 — Surrogate Endpoint (SUR): Blood pressure
Study 23642785 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 17126585 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29221604 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 29221604 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19662781 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15342289 — Surrogate Endpoint (SUR): Serum creatinine
Study 15342289 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 26871847 — Surrogate Endpoint (SUR): Blood pressure
Study 22670617 — Predictive Biomarker (PRD): S100A8 mRNA
Genes: S100A8; CAGA; CFAG; MRP8
Study 22670617 — Predictive Biomarker (PRD): Calgranulin B
Genes: S100A9; CAGB; CFAG; MRP14
Study 22670617 — Predictive Biomarker (PRD): S100A11 mRNA
Genes: S100A11; MLN70; S100C
Study 18609169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 7599749 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 7599749 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15190957 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 9886901 — Surrogate Endpoint (SUR): Blood pressure
Study 25579161 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25579161 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19552840 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 19552840 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 16036036 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16753012 — Predictive Biomarker (PRD): GET4 mRNA
Genes: GET4; C7orf20; CEE; TRC35; CGI-20
Study 9491191 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 26639957 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 10371365 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30134291 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30134291 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 30134291 — Predictive Biomarker (PRD): SRY mRNA
Genes: SRY; TDF
Study 30134291 — Surrogate Endpoint (SUR): Bone mineral density
Study 30134291 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 9585392 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21737560 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18421187 — Surrogate Endpoint (SUR): Bone mineral density
Study 3657889 — Surrogate Endpoint (SUR): Blood pressure
Study 28298558 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 21062996 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 14732977 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 14732977 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 14732977 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11032585 — Predictive Biomarker (PRD): EMB mRNA
Genes: EMB
Study 27998448 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 27998448 — Predictive Biomarker (PRD): UIMC1 mRNA
Genes: UIMC1; RAP80; RXRIP110
Study 20702806 — Surrogate Endpoint (SUR): Blood pressure
Study 31422924 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 31064965 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19303137 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 30125349 — Predictive Biomarker (PRD): MRC1 mRNA
Genes: MRC1; CLEC13D; CLEC13DL; MRC1L1
Study 16190387 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1957553 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 22441104 — Monitoring Biomarker (MOI): HBV DNA
Study 20430207 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 20430207 — Surrogate Endpoint (SUR): Serum creatinine
Study 6754067 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 12511182 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 27812689 — Predictive Biomarker (PRD): FCGR2A mRNA
Genes: FCGR2A; CD32; FCG2; FCGR2A1; IGFR2
Study 27812689 — Predictive Biomarker (PRD): FCGR3A mRNA
Genes: FCGR3A; CD16A; FCG3; FCGR3; IGFR3
Study 27812689 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 21631929 — Surrogate Endpoint (SUR): Blood pressure
Study 19459520 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19459520 — Surrogate Endpoint (SUR): Serum potassium
Study 29400697 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21513602 — Surrogate Endpoint (SUR): Blood pressure
Study 453287 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 16305899 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16305899 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16305899 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 30835574 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 30835574 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 30835574 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 21170734 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 19770794 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9671009 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 30020510 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 19282417 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 8739554 — Surrogate Endpoint (SUR): Blood pressure
Study 2009163 — Surrogate Endpoint (SUR): Blood pressure
Study 27435303 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 26148915 — Surrogate Endpoint (SUR): Blood pressure
Study 19004846 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 17691579 — Surrogate Endpoint (SUR): Blood pressure
Study 28738708 — Predictive Biomarker (PRD): HBB mRNA
Genes: HBB
Study 18705532 — Surrogate Endpoint (SUR): Blood pressure
Study 10791875 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6383687 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6383687 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2879444 — Surrogate Endpoint (SUR): Blood pressure
Study 2879444 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25089359 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25089359 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 14644397 — Predictive Biomarker (PRD): ACAT1 mRNA
Genes: ACAT1; ACAT; MAT
Study 14644397 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 14644397 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14644397 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1576117 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31662396 — Surrogate Endpoint (SUR): Blood pressure
Study 17545883 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 11120696 — Surrogate Endpoint (SUR): Blood pressure
Study 29705459 — Surrogate Endpoint (SUR): Blood pressure
Study 24201696 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16402614 — Surrogate Endpoint (SUR): Blood pressure
Study 3340909 — Surrogate Endpoint (SUR): Blood pressure
Study 28500216 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 7595905 — Surrogate Endpoint (SUR): Blood pressure
Study 645143 — Surrogate Endpoint (SUR): Blood pressure
Study 20388753 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 15606435 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 12199005 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 7074752 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29980770 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 7851581 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 26175552 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 15096808 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11479153 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Hepatocyte growth factor
Genes: HGF; HPTA
Study 2646872 — Surrogate Endpoint (SUR): Blood pressure
Study 1239216 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18048452 — Surrogate Endpoint (SUR): Blood pressure
Study 12876237 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 21864866 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 20550712 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20550712 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20550712 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18094378 — Monitoring Biomarker (MOI): HBV DNA
Study 14579089 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 27116510 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 27116510 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 27116510 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27116510 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 27116510 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 18418230 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18418230 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18418230 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 10705622 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 25622744 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 25622744 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25622744 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25622744 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 25622744 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 17474806 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 17474806 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 15526245 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3737040 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 15641931 — Surrogate Endpoint (SUR): Blood pressure
Study 8582096 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 8582096 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 30260794 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 17100937 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 17100937 — Predictive Biomarker (PRD): GNAQ mRNA
Genes: GNAQ; GAQ
Study 28441325 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 28441325 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 28441325 — Safety Biomarker (SAF): BDNF
Study 28441325 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 26643993 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26643993 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 17298708 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 31634189 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2856892 — Surrogate Endpoint (SUR): Blood pressure
Study 22350194 — Surrogate Endpoint (SUR): Blood pressure
Study 8233775 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8689424 — Predictive Biomarker (PRD): PF4 mRNA
Genes: PF4; CXCL4; SCYB4
Study 8689424 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31553410 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31553410 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6626409 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 26674334 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 19558807 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 17188044 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 28361573 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 28361573 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28361573 — Surrogate Endpoint (SUR): Blood pressure
Study 23123043 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 21385346 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 18206175 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 6510459 — Surrogate Endpoint (SUR): Blood pressure
Study 31422671 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31422671 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17519148 — Predictive Biomarker (PRD): NES mRNA
Genes: NES; Nbla00170
Study 17519148 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 17519148 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 17519148 — Surrogate Endpoint (SUR): Blood pressure
Study 17519148 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17519148 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15550579 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 8379508 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30151705 — Surrogate Endpoint (SUR): Probing pocket depth
Study 28848182 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 28848182 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 25456153 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25456153 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24811959 — Predictive Biomarker (PRD): OCA2 mRNA
Genes: OCA2; D15S12; P
Study 17301734 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 21693215 — Surrogate Endpoint (SUR): Serum creatinine
Study 19487934 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 17270674 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 10976543 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 8974126 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8974126 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 6089581 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 6089581 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 6089581 — Safety Biomarker (SAF): Succinate dehydrogenase
Genes: SDHD
Study 6089581 — Safety Biomarker (SAF): Cytochrome c
Study 3784283 — Surrogate Endpoint (SUR): Serum sodium
Study 26776557 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18428198 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1308263 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15730434 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15730434 — Surrogate Endpoint (SUR): Blood pressure