TrialPanorama/TrialPanorama-database huggingface dataset:
Study 29038157 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 14669165 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31805989 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24041301 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 30685440 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16945213 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10749783 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8703455 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 8703455 — Surrogate Endpoint (SUR): Blood pressure
Study 1305043 — Surrogate Endpoint (SUR): Blood pressure
Study 3977491 — Predictive Biomarker (PRD): CLYBL mRNA
Genes: CLYBL; CLB
Study 29884682 — Surrogate Endpoint (SUR): Blood pressure
Study 23197572 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 16395320 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9104618 — Predictive Biomarker (PRD): CD79A mRNA
Genes: CD79A; IGA; MB1
Study 8478668 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 12198052 — Surrogate Endpoint (SUR): Blood pressure
Study 16435471 — Surrogate Endpoint (SUR): Serum testosterone
Study 25294016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25294016 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21255957 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19593886 — Surrogate Endpoint (SUR): Blood pressure
Study 15296886 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 9285433 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 29853453 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20619475 — Predictive Biomarker (PRD): F3 mRNA
Genes: F3
Study 8852414 — Predictive Biomarker (PRD): SECTM1 mRNA
Genes: SECTM1; K12
Study 31575423 — Surrogate Endpoint (SUR): Blood pressure
Study 10581593 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8074597 — Surrogate Endpoint (SUR): Serum calcium
Study 28583396 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23413998 — Predictive Biomarker (PRD): LTA mRNA
Genes: LTA; TNFB; TNFSF1
Study 23413998 — Predictive Biomarker (PRD): VASP mRNA
Genes: VASP
Study 8123500 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 28837504 — Surrogate Endpoint (SUR): Bone mineral density
Study 25319385 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 31124042 — Surrogate Endpoint (SUR): Bone mineral density
Study 1396624 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27428192 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27428192 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31553834 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28915826 — Surrogate Endpoint (SUR): Blood pressure
Study 26086941 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 26086941 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8459971 — Surrogate Endpoint (SUR): Bone mineral density
Study 8459971 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30225268 — Surrogate Endpoint (SUR): Blood pressure
Study 26795100 — Surrogate Endpoint (SUR): Serum sodium
Study 19539141 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 2104627 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 2104627 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31277886 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 26071592 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11020745 — Surrogate Endpoint (SUR): Blood pressure
Study 21242364 — Surrogate Endpoint (SUR): Blood pressure
Study 8112370 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 8112370 — Surrogate Endpoint (SUR): Blood pressure
Study 8112370 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 30048473 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30048473 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12369652 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 12369652 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26418022 — Surrogate Endpoint (SUR): Blood pressure
Study 17088770 — Safety Biomarker (SAF): Hyaluronic acid
Study 10997402 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28441294 — Predictive Biomarker (PRD): SIRPA mRNA
Genes: SIRPA; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP
Study 21396214 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 21396214 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21396214 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18510607 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8971427 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8971427 — Surrogate Endpoint (SUR): Blood pressure
Study 30318561 — Surrogate Endpoint (SUR): Blood pressure
Study 21287409 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 25409877 — Surrogate Endpoint (SUR): Blood pressure
Study 23585522 — Surrogate Endpoint (SUR): Hematologic response
Study 3498395 — Surrogate Endpoint (SUR): Blood pressure
Study 29314455 — Surrogate Endpoint (SUR): Blood pressure
Study 23898483 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23898483 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 23898483 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 20204604 — Surrogate Endpoint (SUR): Bone mineral density
Study 7948800 — Surrogate Endpoint (SUR): Blood pressure
Study 2451883 — Predictive Biomarker (PRD): PIK3AP1 mRNA
Genes: PIK3AP1; BCAP
Study 26253933 — Predictive Biomarker (PRD): TLR2 mRNA
Genes: TLR2; TIL4
Study 26253933 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 26253933 — Predictive Biomarker (PRD): TICAM1 mRNA
Genes: TICAM1; PRVTIRB; TRIF
Study 26253933 — Predictive Biomarker (PRD): TLR2
Genes: TIL4; CD282
Study 26253933 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21247733 — Surrogate Endpoint (SUR): Blood pressure
Study 12928941 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12928941 — Safety Biomarker (SAF): Interleukin 1
Study 21898340 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 9040450 — Surrogate Endpoint (SUR): Blood pressure
Study 9040450 — Safety Biomarker (SAF): ACE
Genes: ACE1; CD143
Study 9040450 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22008690 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22008690 — Surrogate Endpoint (SUR): Blood pressure
Study 14533665 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 9635271 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 25348000 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 25348000 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25348000 — Predictive Biomarker (PRD): Hormone receptor
Study 25348000 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19741509 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 3116982 — Surrogate Endpoint (SUR): Serum potassium
Study 25351788 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 2975290 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2975290 — Surrogate Endpoint (SUR): Blood pressure
Study 24331681 — Surrogate Endpoint (SUR): Blood pressure
Study 6729769 — Surrogate Endpoint (SUR): Serum uric acid
Study 29228205 — Predictive Biomarker (PRD): PGR mRNA
Genes: PGR; NR3C3
Study 29228205 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 29228205 — Predictive Biomarker (PRD); Safety Biomarker (SAF): ESR2 mRNA
Genes: ESR2; ESTRB; NR3A2
Study 29228205 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CYP17A1 mRNA
Genes: CYP17A1; CYP17; S17AH
Study 29228205 — Safety Biomarker (SAF): HSD17B1 mRNA
Genes: HSD17B1; E17KSR; EDH17B1; EDH17B2; EDHB17; SDR28C1
Study 29228205 — Predictive Biomarker (PRD): CYP19A1 mRNA
Genes: CYP19A1; ARO1; CYAR; CYP19
Study 29228205 — Predictive Biomarker (PRD): CYP1A1 mRNA
Genes: CYP1A1
Study 29228205 — Predictive Biomarker (PRD): CYP1B1 mRNA
Genes: CYP1B1
Study 29228205 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 29228205 — Predictive Biomarker (PRD): UGT2B7 mRNA
Genes: UGT2B7; UGTB2B9
Study 29228205 — Predictive Biomarker (PRD): UGT2B15 mRNA
Genes: UGT2B15; UGT2B8
Study 17913669 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 10396719 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 29880794 — Predictive Biomarker (PRD): ID1 mRNA
Genes: ID1; BHLHB24; ID
Study 25196041 — Pharmacodynamic Biomarker (PDY): Mismatch negativity
Study 21896498 — Surrogate Endpoint (SUR): Serum creatinine
Study 12516653 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 12516653 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31105703 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31105703 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27853886 — Surrogate Endpoint (SUR): Blood pressure
Study 21762532 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 15302008 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 29483583 — Predictive Biomarker (PRD): ETV6 mRNA
Genes: ETV6; TEL; TEL1
Study 8139085 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8139085 — Surrogate Endpoint (SUR): Blood pressure
Study 8139085 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23517506 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 16778364 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 8512601 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8512601 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26561294 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26561294 — Surrogate Endpoint (SUR): Blood pressure
Study 19309495 — Safety Biomarker (SAF): IL-6 and IL-10
Study 30912285 — Predictive Biomarker (PRD): NLRP3 mRNA
Genes: NLRP3; C1orf7; CIAS1; NALP3; PYPAF1
Study 30912285 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 1 beta
Genes: IL1B; IL1F2
Study 29049251 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 20329604 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 408607 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 3511693 — Surrogate Endpoint (SUR): Blood pressure
Study 3511693 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3511693 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26690310 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 26690310 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 22065400 — Predictive Biomarker (PRD): SKI mRNA
Genes: SKI
Study 22065400 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 16020405 — Surrogate Endpoint (SUR): Blood pressure
Study 7832332 — Surrogate Endpoint (SUR): Blood pressure
Study 24839144 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 24839144 — Predictive Biomarker (PRD): Forkhead box protein P3
Genes: FOXP3; IPEX; JM2
Study 24839144 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20590588 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 20590588 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 15795705 — Surrogate Endpoint (SUR): Blood pressure
Study 7807033 — Surrogate Endpoint (SUR): Blood pressure
Study 1778219 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 1778219 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 1778219 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 6168121 — Surrogate Endpoint (SUR): Blood pressure
Study 25985241 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 25985241 — Surrogate Endpoint (SUR): Serum calcium
Study 25985241 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17929538 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 31250043 — Surrogate Endpoint (SUR): Bone mineral density
Study 18632657 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 16212580 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 11513771 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 30571543 — Predictive Biomarker (PRD): NE
Study 30571543 — Surrogate Endpoint (SUR): Blood pressure
Study 27863845 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 15100679 — Surrogate Endpoint (SUR): Hemagglutination inhibition antibody
Study 27282755 — Surrogate Endpoint (SUR): Blood pressure
Study 16872952 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 10657867 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 3524588 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 28914726 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17287908 — Surrogate Endpoint (SUR): Bone mineral density
Study 12139543 — Surrogate Endpoint (SUR): Blood pressure
Study 9459316 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 9459316 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 9459316 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 7657419 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 20580618 — Predictive Biomarker (PRD): GAD2 mRNA
Genes: GAD2; GAD65
Study 10199877 — Surrogate Endpoint (SUR): Blood pressure
Study 29374510 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 15792016 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 11574441 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 8800732 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 21088211 — Surrogate Endpoint (SUR): Blood pressure
Study 16903595 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 2892143 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26783268 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 9007178 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 25225436 — Predictive Biomarker (PRD): PDGFRB mRNA
Genes: PDGFRB; PDGFR; PDGFR1
Study 25225436 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 7714086 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2692963 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2692963 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11358646 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3261158 — Predictive Biomarker (PRD): RASL12 mRNA
Genes: RASL12; RIS
Study 26456372 — Surrogate Endpoint (SUR): Forced vital capacity
Study 21505506 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21505506 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17664851 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22811306 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22811306 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 22811306 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22811306 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 2288828 — Surrogate Endpoint (SUR): Blood pressure
Study 16965635 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11232497 — Monitoring Biomarker (MOI): HBV DNA
Study 30795958 — Monitoring Biomarker (MOI): HBV DNA
Study 28847886 — Surrogate Endpoint (SUR): Blood pressure
Study 26346302 — Predictive Biomarker (PRD): FADS1 mRNA
Genes: FADS1; FADSD5
Study 19770624 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19770624 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19770624 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23512743 — Surrogate Endpoint (SUR): Blood pressure
Study 14508127 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 22527222 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 2766661 — Surrogate Endpoint (SUR): Blood pressure
Study 20185560 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 6274471 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 6274471 — Surrogate Endpoint (SUR): Blood pressure
Study 22732511 — Surrogate Endpoint (SUR): Serum creatinine
Study 7805235 — Surrogate Endpoint (SUR): Blood pressure
Study 7250172 — Surrogate Endpoint (SUR): Blood pressure
Study 7250172 — Surrogate Endpoint (SUR): Serum potassium
Study 15025612 — Predictive Biomarker (PRD): SPIN1 mRNA
Genes: SPIN1; OCR; SPIN
Study 9267946 — Surrogate Endpoint (SUR): Blood pressure
Study 8305657 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 20298924 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16422888 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12829908 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 2 receptor alpha
Genes: IL2RA
Study 30407312 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30407312 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 26610643 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 24253758 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 22124880 — Predictive Biomarker (PRD): SLCO1A2 mRNA
Genes: SLCO1A2; OATP; OATP1; OATP1A2; SLC21A3
Study 22124880 — Predictive Biomarker (PRD): SLCO2B1 mRNA
Genes: SLCO2B1; KIAA0880; OATP2B1; OATPB; SLC21A9
Study 31977567 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 31894027 — Surrogate Endpoint (SUR): Blood pressure
Study 21420053 — Surrogate Endpoint (SUR): Serum creatinine
Study 10848875 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 20637971 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 11952447 — Surrogate Endpoint (SUR): Blood pressure
Study 2650941 — Surrogate Endpoint (SUR): Blood pressure
Study 2650941 — Surrogate Endpoint (SUR): Serum creatinine
Study 368306 — Surrogate Endpoint (SUR): Blood pressure
Study 21792215 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 15580149 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12001978 — Safety Biomarker (SAF): MTHFR
Study 3228817 — Surrogate Endpoint (SUR): Blood pressure
Study 24725308 — Surrogate Endpoint (SUR): Blood pressure
Study 22960196 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 16250568 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 16250568 — Surrogate Endpoint (SUR): Probing pocket depth
Study 12404673 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 21505304 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 21505304 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21505304 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 10862159 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24708818 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 24708818 — Surrogate Endpoint (SUR): Blood pressure
Study 22607767 — Surrogate Endpoint (SUR): Serum testosterone
Study 20518615 — Safety Biomarker (SAF): Interleukin 1
Study 18571083 — Safety Biomarker (SAF): Hyaluronic acid
Study 8605790 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28922099 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28922099 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 28922099 — Predictive Biomarker (PRD): LDLR mRNA
Genes: LDLR
Study 28922099 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8