TrialPanorama/TrialPanorama-database huggingface dataset:
Study 22678104 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 22678104 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11795674 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11795674 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10445766 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9829638 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26022815 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 26022815 — Surrogate Endpoint (SUR): Blood pressure
Study 26022815 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 23497457 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23497457 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 23497457 — Surrogate Endpoint (SUR): Blood pressure
Study 23497457 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 17229769 — Predictive Biomarker (PRD): CHM mRNA
Genes: CHM; REP1; TCD
Study 20834180 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 15766322 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 29950170 — Predictive Biomarker (PRD): NBN mRNA
Genes: NBN; NBS; NBS1; P95
Study 22997893 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22997893 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20175107 — Predictive Biomarker (PRD): HPSE mRNA
Genes: HPSE; HEP; HPA; HPA1; HPR1; HPSE1; HSE1
Study 10469959 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 8339631 — Surrogate Endpoint (SUR): Blood pressure
Study 19194319 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11273109 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8294092 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 2646188 — Surrogate Endpoint (SUR): Blood pressure
Study 31621258 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 9155717 — Predictive Biomarker (PRD): MUC2 mRNA
Genes: MUC2; SMUC
Study 9155717 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 25399007 — Surrogate Endpoint (SUR): Serum creatinine
Study 20394790 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 18042650 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 19441870 — Surrogate Endpoint (SUR): Blood pressure
Study 8392287 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 8392287 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 30697968 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22803428 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 22803428 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 22803428 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22803428 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12621778 — Surrogate Endpoint (SUR): Serum creatinine
Study 10342084 — Surrogate Endpoint (SUR): Serum triglycerides
Study 10342084 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6284687 — Surrogate Endpoint (SUR): Blood pressure
Study 31092125 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 2024540 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20023292 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 10826387 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 22728908 — Surrogate Endpoint (SUR): Blood pressure
Study 17131847 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17131847 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 26439877 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 12749487 — Predictive Biomarker (PRD): TMPRSS13 mRNA
Genes: TMPRSS13; MSP; TMPRSS11
Study 9530459 — Surrogate Endpoint (SUR): Blood pressure
Study 12848597 — Surrogate Endpoint (SUR): Blood pressure
Study 10706056 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29911893 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29911893 — Surrogate Endpoint (SUR): Blood pressure
Study 29247148 — Monitoring Biomarker (MOI): Adenosine deaminase
Genes: ADA; ADA1
Study 27160199 — Surrogate Endpoint (SUR): Blood pressure
Study 22769235 — Surrogate Endpoint (SUR): Bone mineral density
Study 12392381 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 8569943 — Surrogate Endpoint (SUR): Blood pressure
Study 1936331 — Surrogate Endpoint (SUR): Sperm parameters
Study 30809536 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30809536 — Surrogate Endpoint (SUR): Blood pressure
Study 29072015 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 29072015 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23353610 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17496227 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 31010570 — Predictive Biomarker (PRD): TRPM8 mRNA
Genes: TRPM8; LTRPC6; TRPP8
Study 29415829 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29415829 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29415829 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 29415829 — Surrogate Endpoint (SUR): Serum creatinine
Study 24093664 — Safety Biomarker (SAF): Hyaluronic acid
Study 2883988 — Surrogate Endpoint (SUR): Blood pressure
Study 17893257 — Surrogate Endpoint (SUR): Blood pressure
Study 7582390 — Surrogate Endpoint (SUR): Blood pressure
Study 2924158 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 31442204 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 24995688 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 18063846 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 18063846 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 9745996 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 8042760 — Surrogate Endpoint (SUR): Blood pressure
Study 26437320 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26437320 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9741512 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30495974 — Predictive Biomarker (PRD): RAPGEF5 mRNA
Genes: RAPGEF5; GFR; KIAA0277; MRGEF
Study 17979895 — Predictive Biomarker (PRD): AFM mRNA
Genes: AFM; ALB2; ALBA
Study 8092097 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2963166 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 2963166 — Surrogate Endpoint (SUR): Blood pressure
Study 25700845 — Predictive Biomarker (PRD): AFM mRNA
Genes: AFM; ALB2; ALBA
Study 19034329 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 19034329 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 15143854 — Predictive Biomarker (PRD): BTG3 mRNA
Genes: BTG3; ANA; TOB5
Study 15143854 — Predictive Biomarker (PRD): SMPD1 mRNA
Genes: SMPD1; ASM
Study 15143854 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 15143854 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 15143854 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 15143854 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 15968385 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 9565507 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 9565507 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 7755480 — Surrogate Endpoint (SUR): Blood pressure
Study 20639765 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 19139435 — Predictive Biomarker (PRD): ALK tyrosine kinase receptor
Genes: ALK
Study 15073108 — Safety Biomarker (SAF): Dihydrothymine dehydrogenase
Genes: DPYD
Study 11455810 — Surrogate Endpoint (SUR): Blood pressure
Study 28118938 — Predictive Biomarker (PRD): TLR3 mRNA
Genes: TLR3
Study 28118938 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24834925 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21705958 — Surrogate Endpoint (SUR): Blood pressure
Study 30822414 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 30822414 — Safety Biomarker (SAF): Hyaluronic acid
Study 28263374 — Surrogate Endpoint (SUR): Blood pressure
Study 26328470 — Surrogate Endpoint (SUR): Blood pressure
Study 26328470 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 26328470 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19692661 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 19692661 — Predictive Biomarker (PRD): ZFP42 mRNA
Genes: ZFP42; REX1; ZNF754
Study 3769897 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 30403006 — Surrogate Endpoint (SUR): Blood pressure
Study 22575166 — Predictive Biomarker (PRD): PNP mRNA
Genes: PNP; NP
Study 12206610 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 7717281 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29410014 — Predictive Biomarker (PRD): JAK1
Genes: JAK1A; JTK3
Study 29410014 — Predictive Biomarker (PRD): JAK2
Genes: JTK10
Study 24892803 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24892803 — Surrogate Endpoint (SUR): Blood pressure
Study 18690839 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 1830450 — Surrogate Endpoint (SUR): Blood pressure
Study 23292545 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 19019053 — Surrogate Endpoint (SUR): Forced vital capacity
Study 15117890 — Surrogate Endpoint (SUR): Bone mineral density
Study 30548252 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-21
Genes: MIR21
Study 24849708 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 24849708 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 27575834 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11006890 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8792045 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8792045 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16287765 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20350051 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 20350051 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 16904419 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 30831601 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 21928106 — Predictive Biomarker (PRD): KLK3 mRNA
Genes: KLK3; APS
Study 10857960 — Surrogate Endpoint (SUR): Serum triglycerides
Study 10857960 — Surrogate Endpoint (SUR): Blood pressure
Study 24449235 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 24449235 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 14523141 — Surrogate Endpoint (SUR): Serum creatinine
Study 29793605 — Surrogate Endpoint (SUR): Blood pressure
Study 18667394 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 8903817 — Surrogate Endpoint (SUR): Serum sodium
Study 8903817 — Surrogate Endpoint (SUR): Serum potassium
Study 16227771 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8586772 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31745044 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20029710 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 27696395 — Predictive Biomarker (PRD): NDP mRNA
Genes: NDP; EVR2
Study 2725118 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TNS1 mRNA
Genes: TNS1; TNS
Study 2725118 — Surrogate Endpoint (SUR): Blood pressure
Study 18687132 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20150825 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 10095800 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 8074019 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8074019 — Surrogate Endpoint (SUR): Blood pressure
Study 17579653 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17065036 — Surrogate Endpoint (SUR): Blood pressure
Study 10873077 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 10873077 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 10873077 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 22100490 — Safety Biomarker (SAF): Reactive oxygen species
Study 22100490 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17141851 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17141851 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 17141851 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11980623 — Surrogate Endpoint (SUR): Serum testosterone
Study 7871179 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24947924 — Monitoring Biomarker (MOI): Angiopoietin-1
Genes: ANGPT1; KIAA0003
Study 16151466 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 30796818 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 17650935 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17650935 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11882227 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 3891188 — Surrogate Endpoint (SUR): Blood pressure
Study 2724276 — Surrogate Endpoint (SUR): Blood pressure
Study 17395895 — Predictive Biomarker (PRD): CBR1 mRNA
Genes: CBR1; CBR; CRN; SDR21C1
Study 9743306 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 24199747 — Surrogate Endpoint (SUR): Blood pressure
Study 21393611 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 21393611 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1839798 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 25304007 — Predictive Biomarker (PRD): XRCC2 mRNA
Genes: XRCC2
Study 20861211 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 20861211 — Surrogate Endpoint (SUR): Blood pressure
Study 18227044 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18227044 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 18227044 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 12297407 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10626187 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 6828827 — Surrogate Endpoint (SUR): Blood pressure
Study 25344019 — Predictive Biomarker (PRD): CNP mRNA
Genes: CNP
Study 16041475 — Predictive Biomarker (PRD): LTB mRNA
Genes: LTB; TNFC; TNFSF3
Study 1990895 — Surrogate Endpoint (SUR): Blood pressure
Study 20937118 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 8586837 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2670657 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2670657 — Surrogate Endpoint (SUR): Blood pressure
Study 31264313 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31264313 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19924244 — Predictive Biomarker (PRD): TCF7L2 mRNA
Genes: TCF7L2; TCF4
Study 10980586 — Surrogate Endpoint (SUR): Blood pressure
Study 18544524 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 30334693 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 24990275 — Predictive Biomarker (PRD): CYBB mRNA
Genes: CYBB; NOX2
Study 24990275 — Predictive Biomarker (PRD): VCAM1 mRNA
Genes: VCAM1
Study 16020940 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16020940 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30867067 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): C-X-C motif chemokine 11
Genes: CXCL11; ITAC; SCYB11; SCYB9B
Study 22516873 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22516873 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 9133967 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30407958 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12867220 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 2115044 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 25019269 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25019269 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 9212963 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 8140175 — Surrogate Endpoint (SUR): Blood pressure
Study 2686713 — Surrogate Endpoint (SUR): Blood pressure
Study 31006801 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18645344 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18645344 — Surrogate Endpoint (SUR): Blood pressure
Study 16437735 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9180629 — Surrogate Endpoint (SUR): Blood pressure
Study 29437573 — Predictive Biomarker (PRD): ABCA1 mRNA
Genes: ABCA1; ABC1; CERP
Study 21729372 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20134330 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28509904 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26267119 — Predictive Biomarker (PRD): NES mRNA
Genes: NES; Nbla00170
Study 21167340 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 1586984 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26773120 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 20631323 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 15743471 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15743471 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 15743471 — Safety Biomarker (SAF): Reactive oxygen species
Study 10588092 — Surrogate Endpoint (SUR): Blood pressure
Study 7783096 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7783096 — Surrogate Endpoint (SUR): Blood pressure
Study 6085365 — Surrogate Endpoint (SUR): Blood pressure
Study 26753844 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26753844 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 3158320 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 3158320 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 23475128 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23475128 — Surrogate Endpoint (SUR): Bone mineral density
Study 21216833 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 21216833 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 18645050 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 18645050 — Surrogate Endpoint (SUR): Blood pressure
Study 18645050 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17074656 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 26922019 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11353931 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 24210549 — Surrogate Endpoint (SUR): Blood pressure
Study 22440192 — Surrogate Endpoint (SUR): Blood pressure
Study 10707131 — Surrogate Endpoint (SUR): Blood pressure
Study 2036478 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 28934604 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 28934604 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23986081 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22397239 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1