TrialPanorama/TrialPanorama-database huggingface dataset:
Study 22301554 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22301554 — Predictive Biomarker (PRD): HSPB1 mRNA
Genes: HSPB1; HSP27; HSP28
Study 22301554 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 22301554 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17999989 — Predictive Biomarker (PRD); Safety Biomarker (SAF): COX2 mRNA
Genes: PTGS2; COX2
Study 20464297 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 20464297 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 25280441 — Predictive Biomarker (PRD): GNB3 mRNA
Genes: GNB3
Study 14566442 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 16752186 — Predictive Biomarker (PRD): ADIPOQ mRNA
Genes: ADIPOQ; ACDC; ACRP30; APM1; GBP28
Study 2567218 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2567218 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27930453 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 17052415 — Surrogate Endpoint (SUR): Blood pressure
Study 24467843 — Predictive Biomarker (PRD): CNP mRNA
Genes: CNP
Study 16245914 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 16245914 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9862566 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 9862566 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 28454795 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 21861333 — Predictive Biomarker (PRD): ALDH2 mRNA
Genes: ALDH2; ALDM
Study 12716777 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6123342 — Surrogate Endpoint (SUR): Blood pressure
Study 31362591 — Surrogate Endpoint (SUR): Blood pressure
Study 21674132 — Surrogate Endpoint (SUR): Blood pressure
Study 8883116 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 8883116 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 27659931 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 20844595 — Predictive Biomarker (PRD): MIA mRNA
Genes: MIA
Study 20844595 — Predictive Biomarker (PRD): COMP mRNA
Genes: COMP
Study 12813615 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 10511062 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 10511062 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 7742773 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 25548798 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25548798 — Surrogate Endpoint (SUR): Blood pressure
Study 11964938 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8291819 — Surrogate Endpoint (SUR): Blood pressure
Study 22281826 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 3142949 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23041585 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 21601973 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 10560752 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7738618 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 1855082 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7323140 — Predictive Biomarker (PRD): CPZ mRNA
Genes: CPZ
Study 31543299 — Surrogate Endpoint (SUR): Probing pocket depth
Study 24089388 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 16513579 — Surrogate Endpoint (SUR): Blood pressure
Study 28980294 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 3900932 — Surrogate Endpoint (SUR): Blood pressure
Study 27314448 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25042605 — Surrogate Endpoint (SUR): Blood pressure
Study 10571498 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24240577 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24240577 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 24240577 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20177030 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 10386423 — Surrogate Endpoint (SUR): Serum creatinine
Study 31797581 — Predictive Biomarker (PRD): NF1 mRNA
Genes: NF1
Study 31463257 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 31463257 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 31463257 — Surrogate Endpoint (SUR): Forced vital capacity
Study 26821779 — Surrogate Endpoint (SUR): Bone mineral density
Study 31744526 — Surrogate Endpoint (SUR): Blood pressure
Study 15855919 — Predictive Biomarker (PRD): MEST mRNA
Genes: MEST; PEG1
Study 12585189 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 22592354 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 27776622 — Surrogate Endpoint (SUR): Blood pressure
Study 22784037 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 14594860 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 9743392 — Surrogate Endpoint (SUR): Blood pressure
Study 28855179 — Surrogate Endpoint (SUR): Blood pressure
Study 16823248 — Surrogate Endpoint (SUR): Blood pressure
Study 9404921 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 15249792 — Surrogate Endpoint (SUR): Blood pressure
Study 29141712 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29141712 — Monitoring Biomarker (MOI): HBV DNA
Study 24686130 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24686130 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15372589 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 3510594 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 28671082 — Predictive Biomarker (PRD): NCAM1 mRNA
Genes: NCAM1; NCAM
Study 19678952 — Predictive Biomarker (PRD): SERPINA1 mRNA
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209
Study 3035002 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 29991053 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 29991053 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 21911122 — Surrogate Endpoint (SUR): Blood pressure
Study 18628529 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18628529 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18628529 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 18628529 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18628529 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6614279 — Surrogate Endpoint (SUR): Blood pressure
Study 2054277 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20669670 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30975666 — Surrogate Endpoint (SUR): Blood pressure
Study 30843602 — Predictive Biomarker (PRD): FXYD1 mRNA
Genes: FXYD1; PLM
Study 27917462 — Predictive Biomarker (PRD): Liver iron
Study 23562353 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 23562353 — Predictive Biomarker (PRD): CCNB1 mRNA
Genes: CCNB1; CCNB
Study 9202917 — Surrogate Endpoint (SUR): Blood pressure
Study 21985524 — Surrogate Endpoint (SUR): Blood pressure
Study 15272643 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 15272643 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15272643 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 8172750 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 8172750 — Surrogate Endpoint (SUR): Serum creatinine
Study 17912747 — Predictive Biomarker (PRD): MYRF mRNA
Genes: MYRF; C11orf9; KIAA0954; MRF
Study 12687650 — Safety Biomarker (SAF): MTHFR
Study 30810465 — Surrogate Endpoint (SUR): Blood pressure
Study 29031905 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 29031905 — Predictive Biomarker (PRD): GGT1 mRNA
Genes: GGT1; GGT
Study 19916292 — Surrogate Endpoint (SUR): Serum testosterone
Study 8995552 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29104179 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 23746564 — Surrogate Endpoint (SUR): Blood pressure
Study 18267977 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16584432 — Predictive Biomarker (PRD): NAAA mRNA
Genes: NAAA; ASAHL; PLT
Study 16584432 — Predictive Biomarker (PRD): CALD1 mRNA
Genes: CALD1; CAD; CDM
Study 9263161 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 29268886 — Predictive Biomarker (PRD): VASP mRNA
Genes: VASP
Study 25844616 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 21813548 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 3010516 — Predictive Biomarker (PRD): ARC mRNA
Genes: ARC; KIAA0278
Study 19834313 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7760868 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 6140939 — Surrogate Endpoint (SUR): Blood pressure
Study 6140939 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24335026 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 17395756 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11433224 — Surrogate Endpoint (SUR): Serum sodium
Study 8179848 — Surrogate Endpoint (SUR): Blood pressure
Study 16150800 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16150800 — Surrogate Endpoint (SUR): Blood pressure
Study 10814909 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 8690829 — Surrogate Endpoint (SUR): Blood pressure
Study 1626680 — Surrogate Endpoint (SUR): Blood pressure
Study 31161374 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 24495481 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 24495481 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 2151874 — Surrogate Endpoint (SUR): Blood pressure
Study 9119980 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9119980 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 9119980 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27779460 — Surrogate Endpoint (SUR): Serum creatinine
Study 27779460 — Surrogate Endpoint (SUR): Blood pressure
Study 7546753 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2265259 — Predictive Biomarker (PRD): Hormone receptor
Study 2265259 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 7417366 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 31426760 — Monitoring Biomarker (MOI): Cell-free DNA
Study 21378213 — Surrogate Endpoint (SUR): Blood pressure
Study 19627261 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 19627261 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 11698604 — Predictive Biomarker (PRD): ASL mRNA
Genes: ASL
Study 11698604 — Predictive Biomarker (PRD): MCAT mRNA
Genes: MCAT; MT
Study 11698604 — Predictive Biomarker (PRD): MAP3K10 mRNA
Genes: MAP3K10; MLK2; MST
Study 29899643 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 25422235 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 25422235 — Predictive Biomarker (PRD): TTR mRNA
Genes: TTR; PALB
Study 27530339 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 27530339 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21570643 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16484769 — Surrogate Endpoint (SUR): Forced vital capacity
Study 10697374 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 31291793 — Safety Biomarker (SAF): Reactive oxygen species
Study 12584787 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 12584787 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 4014126 — Surrogate Endpoint (SUR): Blood pressure
Study 20842168 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29512972 — Predictive Biomarker (PRD): AGA mRNA
Genes: AGA
Study 19940079 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 12145221 — Surrogate Endpoint (SUR): Blood pressure
Study 7824108 — Surrogate Endpoint (SUR): Plasma ammonia
Study 204949 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 23822689 — Surrogate Endpoint (SUR): Blood pressure
Study 11046100 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11046100 — Surrogate Endpoint (SUR): Blood pressure
Study 9381993 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9381993 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9381993 — Surrogate Endpoint (SUR): Blood pressure
Study 7780255 — Surrogate Endpoint (SUR): Bone mineral density
Study 28958502 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 25499852 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 25499852 — Surrogate Endpoint (SUR): Blood pressure
Study 18056792 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18056792 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 17263277 — Surrogate Endpoint (SUR): Blood pressure
Study 12728159 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 11590493 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29914095 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27893675 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 28372647 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8005898 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 10515247 — Predictive Biomarker (PRD): Lymphocyte activation antigen CD30
Genes: TNFRSF8; CD30; D1S166E
Study 10515247 — Safety Biomarker (SAF): Interleukin 1
Study 10515247 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 10515247 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28658162 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19164205 — Predictive Biomarker (PRD): CYP1A1 mRNA
Genes: CYP1A1
Study 30648677 — Surrogate Endpoint (SUR): Blood pressure
Study 27086671 — Surrogate Endpoint (SUR): Blood pressure
Study 9787651 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9787651 — Surrogate Endpoint (SUR): Blood pressure
Study 12559482 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 19155900 — Surrogate Endpoint (SUR): Blood pressure
Study 229780 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 15086477 — Surrogate Endpoint (SUR): Serum creatinine
Study 8137524 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29787478 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29787478 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8993769 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 1482265 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1482265 — Surrogate Endpoint (SUR): Blood pressure
Study 31679509 — Surrogate Endpoint (SUR): Blood pressure
Study 24932599 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19716961 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 30730785 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 29573207 — Surrogate Endpoint (SUR): Duration of severe neutropenia
Study 29573207 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 15712594 — Surrogate Endpoint (SUR): Blood pressure
Study 15712594 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 25183507 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25183507 — Surrogate Endpoint (SUR): Blood pressure
Study 30861351 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 22126416 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 913045 — Surrogate Endpoint (SUR): Plasma phenylalanine
Study 6758933 — Surrogate Endpoint (SUR): Blood pressure
Study 24910199 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 24910199 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 22810991 — Surrogate Endpoint (SUR): Blood pressure
Study 22810991 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 12817528 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 22270216 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 25086653 — Predictive Biomarker (PRD); Safety Biomarker (SAF): miR-122
Genes: MIR122
Study 25086653 — Safety Biomarker (SAF): Glutamate dehydrogenase
Study 22172638 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 19466245 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 9667295 — Surrogate Endpoint (SUR): Blood pressure
Study 2636858 — Surrogate Endpoint (SUR): Blood pressure
Study 15233978 — Surrogate Endpoint (SUR): Blood pressure
Study 3555587 — Surrogate Endpoint (SUR): Blood pressure
Study 23434165 — Surrogate Endpoint (SUR): Serum triglycerides
Study 23434165 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8407753 — Surrogate Endpoint (SUR): Blood pressure
Study 3948857 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 17288679 — Surrogate Endpoint (SUR): Blood pressure
Study 16053996 — Surrogate Endpoint (SUR): Blood pressure
Study 25449714 — Predictive Biomarker (PRD): GLP1R mRNA
Genes: GLP1R
Study 20102935 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18840838 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 8560999 — Surrogate Endpoint (SUR): Blood pressure
Study 18581513 — Pharmacodynamic Biomarker (PDY): Pyruvate dehydrogenase kinase 1
Genes: PDK1; PDHK1
Study 15942580 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15942580 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 15942580 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 15942580 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 8806289 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 29086614 — Surrogate Endpoint (SUR): Blood pressure
Study 26460632 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 15947501 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 1707646 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24273218 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22941466 — Predictive Biomarker (PRD): ADAM8 mRNA
Genes: ADAM8; MS2
Study 22941466 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 18979163 — Surrogate Endpoint (SUR): Bone mineral density
Study 8681660 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 19100012 — Predictive Biomarker (PRD): MFSD11 mRNA
Genes: MFSD11; ET
Study 27320368 — Surrogate Endpoint (SUR): Blood pressure
Study 20308694 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15739035 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 15739035 — Surrogate Endpoint (SUR): Bone mineral density
Study 28748002 — Predictive Biomarker (PRD): MLH1 mRNA
Genes: MLH1; COCA2
Study 28748002 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 28748002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 10792560 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 10792560 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 10792560 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 31486356 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 24528693 — Surrogate Endpoint (SUR): Serum triglycerides
Study 24528693 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19156926 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 17227902 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 15753495 — Surrogate Endpoint (SUR): Blood pressure
Study 2165899 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 31870702 — Predictive Biomarker (PRD): OCA2 mRNA
Genes: OCA2; D15S12; P
Study 28298393 — Predictive Biomarker (PRD): MMRN1 mRNA
Genes: MMRN1; ECM; EMILIN4; GPIA*; MMRN
Study 16366740 — Surrogate Endpoint (SUR): Blood pressure
Study 14668077 — Predictive Biomarker (PRD): DRD2 mRNA
Genes: DRD2
Study 14668077 — Safety Biomarker (SAF): DRD2
Study 31292644 — Surrogate Endpoint (SUR): Blood pressure
Study 31527167 — Predictive Biomarker (PRD): CDK4 mRNA
Genes: CDK4
Study 31527167 — Safety Biomarker (SAF): PDCD1
Genes: CD279; PD1; hSLE1; PD-1
Study 31527167 — Predictive Biomarker (PRD): FGFR2 mRNA
Genes: FGFR2; BEK; KGFR; KSAM
Study 31527167 — Predictive Biomarker (PRD): ERBB3 mRNA
Genes: ERBB3; HER3