TrialPanorama/TrialPanorama-database huggingface dataset:
Study 19817986 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 22304443 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 16252734 — Surrogate Endpoint (SUR): Blood pressure
Study 1876419 — Surrogate Endpoint (SUR): Blood pressure
Study 31329855 — Predictive Biomarker (PRD): APOC3 mRNA
Genes: APOC3
Study 31329855 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31329855 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26171911 — Monitoring Biomarker (MOI): Angiopoietin-1
Genes: ANGPT1; KIAA0003
Study 26171911 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Angiopoietin-2
Genes: ANGPT2
Study 24029303 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24029303 — Surrogate Endpoint (SUR): Blood pressure
Study 24029303 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24029303 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18193489 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 18193489 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 12969103 — Surrogate Endpoint (SUR): Blood pressure
Study 1345260 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1345260 — Surrogate Endpoint (SUR): Blood pressure
Study 3974160 — Surrogate Endpoint (SUR): Blood pressure
Study 10216810 — Surrogate Endpoint (SUR): Blood pressure
Study 8582497 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 30608872 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 20086201 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 30472318 — Predictive Biomarker (PRD): FANCE mRNA
Genes: FANCE; FACE
Study 25576879 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 22322513 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22322513 — Surrogate Endpoint (SUR): Probing pocket depth
Study 12395437 — Surrogate Endpoint (SUR): Serum creatinine
Study 7748985 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 2148224 — Surrogate Endpoint (SUR): Blood pressure
Study 26022239 — Predictive Biomarker (PRD): CDKN2A mRNA
Genes: CDKN2A; CDKN2; MTS1
Study 26022239 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 26022239 — Predictive Biomarker (PRD): MYC mRNA
Genes: MYC; BHLHE39
Study 26022239 — Pharmacodynamic Biomarker (PDY): Retinoblastoma-associated protein
Genes: RB1
Study 17169762 — Predictive Biomarker (PRD): HDC mRNA
Genes: HDC
Study 15298795 — Pharmacodynamic Biomarker (PDY): Error related negativity
Study 1572111 — Surrogate Endpoint (SUR): Serum uric acid
Study 4048886 — Surrogate Endpoint (SUR): Blood pressure
Study 23849965 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21730029 — Predictive Biomarker (PRD): PTN mRNA
Genes: PTN; HBNF1; NEGF1
Study 21730029 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 21730029 — Predictive Biomarker (PRD): PPARG mRNA
Genes: PPARG; NR1C3
Study 21730029 — Predictive Biomarker (PRD): PPARGC1A mRNA
Genes: PPARGC1A; LEM6; PGC1; PGC1A; PPARGC1
Study 17895513 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 17895513 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17895513 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 17349094 — Surrogate Endpoint (SUR): Blood pressure
Study 15248628 — Surrogate Endpoint (SUR): Blood pressure
Study 8956395 — Surrogate Endpoint (SUR): Blood pressure
Study 31647836 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 19056532 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 3782648 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 30722837 — Surrogate Endpoint (SUR): Blood pressure
Study 24842558 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15867404 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15867404 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12651685 — Surrogate Endpoint (SUR): Serum sodium
Study 12651685 — Surrogate Endpoint (SUR): Serum potassium
Study 2341828 — Surrogate Endpoint (SUR): Blood pressure
Study 6376030 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 31661346 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 29868916 — Surrogate Endpoint (SUR): Blood pressure
Study 27843084 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 14574083 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 14574083 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 14574083 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 24874737 — Pharmacodynamic Biomarker (PDY): Synuclein alpha
Genes: SNCA; NACP; PARK1
Study 22851072 — Surrogate Endpoint (SUR): Blood pressure
Study 8618580 — Monitoring Biomarker (MOI): HBV DNA
Study 23569301 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 31147243 — Surrogate Endpoint (SUR): Blood pressure
Study 29970139 — Predictive Biomarker (PRD): HAL mRNA
Genes: HAL; HIS
Study 23023905 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23023905 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23023905 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 19778673 — Surrogate Endpoint (SUR): Blood pressure
Study 19778673 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15132730 — Safety Biomarker (SAF): Interleukin 1
Study 15132730 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15132730 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 11488362 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 9733153 — Surrogate Endpoint (SUR): Blood pressure
Study 2256489 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2256489 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23522152 — Monitoring Biomarker (MOI): Procalcitonin
Study 4057126 — Surrogate Endpoint (SUR): Blood pressure
Study 29283931 — Surrogate Endpoint (SUR): Blood pressure
Study 20491047 — Surrogate Endpoint (SUR): Blood pressure
Study 7286051 — Surrogate Endpoint (SUR): Blood pressure
Study 7286051 — Surrogate Endpoint (SUR): Serum uric acid
Study 7286051 — Surrogate Endpoint (SUR): Serum potassium
Study 26483221 — Surrogate Endpoint (SUR): Blood pressure
Study 23554155 — Surrogate Endpoint (SUR): Blood pressure
Study 15036568 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15036568 — Surrogate Endpoint (SUR): Blood pressure
Study 23299526 — Surrogate Endpoint (SUR): Pathological complete response
Study 16836503 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30978117 — Monitoring Biomarker (MOI): Heme oxygenase 1
Genes: HMOX1; HO; HO1
Study 19640954 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11262775 — Surrogate Endpoint (SUR): Bone mineral density
Study 7994450 — Surrogate Endpoint (SUR): Blood pressure
Study 16840744 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15115092 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9167761 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 9167761 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 3026552 — Surrogate Endpoint (SUR): Blood pressure
Study 3026552 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 29696918 — Predictive Biomarker (PRD): TBXT mRNA
Genes: TBXT; T
Study 22698027 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22698027 — Surrogate Endpoint (SUR): Blood pressure
Study 17879948 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 7860545 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7860545 — Surrogate Endpoint (SUR): Serum triglycerides
Study 1111368 — Surrogate Endpoint (SUR): Blood pressure
Study 31775404 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31775404 — Safety Biomarker (SAF): IL-6 and IL-10
Study 19791828 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 3104753 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 8967668 — Surrogate Endpoint (SUR): Bone mineral density
Study 1657221 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 22349765 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 16125534 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 16125534 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16125534 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 25200848 — Surrogate Endpoint (SUR): Serum creatinine
Study 17544857 — Surrogate Endpoint (SUR): Blood pressure
Study 15060257 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 11023935 — Surrogate Endpoint (SUR): Blood pressure
Study 30798568 — Surrogate Endpoint (SUR): Sperm parameters
Study 11409225 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 27647263 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20643827 — Safety Biomarker (SAF): Clusterin
Genes: CLU; APOJ; CLI; KUB1; AAG4
Study 20643827 — Predictive Biomarker (PRD): SERPINA1 mRNA
Genes: SERPINA1; AAT; PI; PRO0684; PRO2209
Study 18984650 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 7796587 — Surrogate Endpoint (SUR): Blood pressure
Study 2442560 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24430095 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 23385792 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 15793163 — Predictive Biomarker (PRD): NAPA mRNA
Genes: NAPA; SNAPA
Study 8359565 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 2444797 — Surrogate Endpoint (SUR): Blood pressure
Study 2550243 — Surrogate Endpoint (SUR): Blood pressure
Study 8908893 — Surrogate Endpoint (SUR): Blood pressure
Study 9607384 — Surrogate Endpoint (SUR): Blood pressure
Study 2899108 — Surrogate Endpoint (SUR): Bacterial count
Study 31753745 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 11379804 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26074402 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 26074402 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 23315596 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 23315596 — Predictive Biomarker (PRD): IGF2 mRNA
Genes: IGF2; PP1446
Study 23315596 — Predictive Biomarker (PRD): IGFBP2 mRNA
Genes: IGFBP2; BP2; IBP2
Study 23315596 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 11717612 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 26397235 — Surrogate Endpoint (SUR): Blood pressure
Study 22948049 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 22948049 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 31551393 — Surrogate Endpoint (SUR): Serum creatinine
Study 26955672 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26955672 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24743706 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 23146806 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23146806 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31533443 — Predictive Biomarker (PRD): PPT1 mRNA
Genes: PPT1; CLN1; PPT
Study 30311691 — Surrogate Endpoint (SUR): Blood pressure
Study 28419315 — Predictive Biomarker (PRD): LTA4H mRNA
Genes: LTA4H; LTA4
Study 25240629 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 25240629 — Monitoring Biomarker (MOI): Tissue transglutaminase
Genes: TGM2
Study 25240629 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 17464237 — Surrogate Endpoint (SUR): Bone mineral density
Study 8709686 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25471276 — Predictive Biomarker (PRD): BCR mRNA
Genes: BCR; BCR1; D22S11
Study 19587642 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 19587642 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19587642 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 17802984 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15055997 — Predictive Biomarker (PRD): EDNRA mRNA
Genes: EDNRA; ETA; ETRA
Study 22990619 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19781131 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17118669 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 7153164 — Surrogate Endpoint (SUR): Blood pressure
Study 22265857 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 2964984 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2964984 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 20186295 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 18844696 — Predictive Biomarker (PRD): CCR1 mRNA
Genes: CCR1; CMKBR1; CMKR1; SCYAR1
Study 15964147 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 10373342 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 7756472 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23899008 — Surrogate Endpoint (SUR): Blood pressure
Study 8572849 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8572849 — Surrogate Endpoint (SUR): Blood pressure
Study 2467982 — Predictive Biomarker (PRD): NAPA mRNA
Genes: NAPA; SNAPA
Study 23266342 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23266342 — Predictive Biomarker (PRD): CCR4 mRNA
Genes: CCR4; CMKBR4
Study 23266342 — Predictive Biomarker (PRD): CCRL2 mRNA
Genes: CCRL2; CCR11; CCR6; CKRX; CRAM; HCR
Study 23266342 — Predictive Biomarker (PRD): CCR7 mRNA
Genes: CCR7; CMKBR7; EBI1; EVI1
Study 23266342 — Predictive Biomarker (PRD): CXCR3 mRNA
Genes: CXCR3; GPR9
Study 30621517 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30621517 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10749622 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 31210557 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 31210557 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18203890 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 2003660 — Surrogate Endpoint (SUR): Blood pressure
Study 15669595 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15669595 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 7864430 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7864430 — Surrogate Endpoint (SUR): Blood pressure
Study 1685993 — Surrogate Endpoint (SUR): Blood pressure
Study 1685993 — Surrogate Endpoint (SUR): Serum potassium
Study 31974142 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 31974142 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 31974142 — Predictive Biomarker (PRD): Small-inducible cytokine A11
Genes: CCL11; SCYA11
Study 24647384 — Surrogate Endpoint (SUR): Blood pressure
Study 7625773 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 7625773 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7625773 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20413036 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 20413036 — Surrogate Endpoint (SUR): Serum creatinine
Study 17953462 — Predictive Biomarker (PRD): OGT mRNA
Genes: OGT
Study 15590244 — Predictive Biomarker (PRD): SSB mRNA
Genes: SSB
Study 20852079 — Surrogate Endpoint (SUR): Bacterial count
Study 19552597 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 16381264 — Surrogate Endpoint (SUR): Blood pressure
Study 8904056 — Surrogate Endpoint (SUR): Blood pressure
Study 30920097 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 26655421 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 19240689 — Safety Biomarker (SAF): Fibroblast growth factor 1
Genes: FGF1
Study 10022444 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 7778470 — Surrogate Endpoint (SUR): Blood pressure
Study 15906078 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 15906078 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 31829220 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 31829220 — Surrogate Endpoint (SUR): Blood pressure
Study 21141322 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 17413035 — Safety Biomarker (SAF): Reactive oxygen species
Study 4499921 — Surrogate Endpoint (SUR): Blood pressure
Study 31174395 — Predictive Biomarker (PRD): HGS mRNA
Genes: HGS; HRS
Study 25927183 — Predictive Biomarker (PRD): CENPJ mRNA
Genes: CENPJ; CPAP; LAP; LIP1
Study 16879301 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 12556915 — Predictive Biomarker (PRD): DRD1 mRNA
Genes: DRD1
Study 21400543 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 21400543 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 20074465 — Surrogate Endpoint (SUR): Bacterial count
Study 3152400 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 21366472 — Surrogate Endpoint (SUR): Serum creatinine
Study 10933269 — Predictive Biomarker (PRD): SLC38A1 mRNA
Genes: SLC38A1; ATA1; NAT2; SAT1; SNAT1
Study 7504134 — Surrogate Endpoint (SUR): Blood pressure
Study 7504134 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20568023 — Surrogate Endpoint (SUR): Serum sodium
Study 17566112 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 17566112 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 16032449 — Surrogate Endpoint (SUR): Blood pressure
Study 1827021 — Surrogate Endpoint (SUR): Blood pressure
Study 1827021 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12505243 — Predictive Biomarker (PRD): GCNT2 mRNA
Genes: GCNT2; GCNT5; II; NACGT1
Study 7623373 — Surrogate Endpoint (SUR): Blood pressure
Study 7623373 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22403202 — Surrogate Endpoint (SUR): Blood pressure
Study 10443654 — Surrogate Endpoint (SUR): Serum testosterone
Study 29211013 — Surrogate Endpoint (SUR): Blood pressure
Study 12182690 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 12182690 — Surrogate Endpoint (SUR): Blood pressure
Study 8905281 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 1653883 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1653883 — Surrogate Endpoint (SUR): Blood pressure
Study 29767459 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29767459 — Surrogate Endpoint (SUR): Serum potassium
Study 24018647 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 16144800 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 7955939 — Surrogate Endpoint (SUR): Blood pressure
Study 20539245 — Surrogate Endpoint (SUR): Blood pressure
Study 17658395 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 29171140 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 1329919 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 30747254 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30747254 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15662502 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 12005179 — Surrogate Endpoint (SUR): Serum calcium
Study 19210150 — Surrogate Endpoint (SUR): Blood pressure
Study 29667217 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 23086138 — Predictive Biomarker (PRD): FFAR1 mRNA
Genes: FFAR1; GPR40
Study 8686973 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26719230 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 24995954 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 16116152 — Predictive Biomarker (PRD): MYCN mRNA
Genes: MYCN; BHLHE37; NMYC
Study 30321486 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30321486 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 3241274 — Surrogate Endpoint (SUR): Blood pressure
Study 23272664 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 14572503 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 29456079 — Monitoring Biomarker (MOI): HBV DNA
Study 19083391 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein