TrialPanorama/TrialPanorama-database huggingface dataset:
Study 11803607 — Surrogate Endpoint (SUR): Serum triglycerides
Study 29540273 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29540273 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 29540273 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 27334799 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 23075680 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 23075680 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 10419989 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2073672 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 2073672 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6459256 — Surrogate Endpoint (SUR): Blood pressure
Study 17148749 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 17148749 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 10541760 — Surrogate Endpoint (SUR): Bone mineral density
Study 277749 — Safety Biomarker (SAF): SLC6A3
Genes: DAT
Study 25421252 — Predictive Biomarker (PRD): Thymidylate synthase 
Genes: TYMS; TS; OK/SW-cl.29
Study 25421252 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25421252 — Predictive Biomarker (PRD): RAD51 mRNA
Genes: RAD51; RAD51A; RECA
Study 25421252 — Safety Biomarker (SAF): Dihydrothymine dehydrogenase
Genes: DPYD
Study 25421252 — Safety Biomarker (SAF): Glutathione S-transferase P
Genes: GSTP1; FAEES3; GST3
Study 25421252 — Predictive Biomarker (PRD): XRCC3 mRNA
Genes: XRCC3
Study 25421252 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 22905926 — Surrogate Endpoint (SUR): Blood pressure
Study 20484058 — Surrogate Endpoint (SUR): Blood pressure
Study 20484058 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12383160 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28616923 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28616923 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PIK3CA
Genes: PI3K
Study 28616923 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 2971310 — Surrogate Endpoint (SUR): Blood pressure
Study 30313092 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 24469870 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 20861530 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 19048591 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19048591 — Surrogate Endpoint (SUR): Serum creatinine
Study 25855267 — Predictive Biomarker (PRD): FMN1 mRNA
Genes: FMN1; FMN; LD
Study 17877165 — Surrogate Endpoint (SUR): Serum bactericidal antibody
Study 31204129 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 9375333 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27982406 — Predictive Biomarker (PRD): LSS mRNA
Genes: LSS; OSC
Study 17269594 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 17269594 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 28478481 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22661646 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20110023 — Surrogate Endpoint (SUR): Blood pressure
Study 15136378 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 11091168 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 11091168 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8445463 — Predictive Biomarker (PRD): DDN mRNA
Genes: DDN; KIAA0749
Study 22498110 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 16172619 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 16172619 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16172619 — Surrogate Endpoint (SUR): Blood pressure
Study 16172619 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 21642014 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21642014 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11742269 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 7509325 — Surrogate Endpoint (SUR): Serum potassium
Study 7509325 — Surrogate Endpoint (SUR): Blood pressure
Study 20962899 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18947475 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 12842526 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 1290620 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1290620 — Surrogate Endpoint (SUR): Blood pressure
Study 6742256 — Surrogate Endpoint (SUR): Blood pressure
Study 30860001 — Predictive Biomarker (PRD): AMPH mRNA
Genes: AMPH; AMPH1
Study 30860001 — Predictive Biomarker (PRD): CYBC1 mRNA
Genes: CYBC1; C17orf62; EROS
Study 23251374 — Surrogate Endpoint (SUR): Blood pressure
Study 19582491 — Surrogate Endpoint (SUR): Blood pressure
Study 2561144 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2561144 — Surrogate Endpoint (SUR): Blood pressure
Study 26062187 — Surrogate Endpoint (SUR): Blood pressure
Study 24135573 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 14706487 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 11990444 — Predictive Biomarker (PRD): EMD mRNA
Genes: EMD; EDMD; STA
Study 9650731 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 786135 — Surrogate Endpoint (SUR): Blood pressure
Study 31625262 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 23507424 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11737418 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 11737418 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 11737418 — Surrogate Endpoint (SUR): Serum testosterone
Study 11737418 — Surrogate Endpoint (SUR): Serum luteinizing hormone
Study 7937352 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 31969108 — Predictive Biomarker (PRD): SLC12A3 mRNA
Genes: SLC12A3; NCC; TSC
Study 16441945 — Predictive Biomarker (PRD): GPX1 mRNA
Genes: GPX1
Study 12829681 — Predictive Biomarker (PRD): ST8SIA4 mRNA
Genes: ST8SIA4; PST; PST1; SIAT8D
Study 29065098 — Surrogate Endpoint (SUR): Blood pressure
Study 16222011 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2278366 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 2278366 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 25438821 — Surrogate Endpoint (SUR): Blood pressure
Study 14531817 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 26498504 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 16046372 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 12032191 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12032191 — Surrogate Endpoint (SUR): Blood pressure
Study 12032191 — Surrogate Endpoint (SUR): Serum potassium
Study 17684963 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15173493 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 27046798 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 27046798 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 17299062 — Surrogate Endpoint (SUR): Serum testosterone
Study 8780347 — Surrogate Endpoint (SUR): Hematologic response
Study 18501444 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 18501444 — Surrogate Endpoint (SUR): Blood pressure
Study 15587771 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 22430687 — Surrogate Endpoint (SUR): Probing pocket depth
Study 19398066 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 14586663 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28165762 — Surrogate Endpoint (SUR): Blood pressure
Study 6378805 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 22214253 — Surrogate Endpoint (SUR): Blood pressure
Study 9721772 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2512938 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 2512938 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 31008902 — Surrogate Endpoint (SUR): Blood pressure
Study 31008902 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31008902 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26185429 — Surrogate Endpoint (SUR): Bone mineral density
Study 26185429 — Surrogate Endpoint (SUR): Serum calcium
Study 15383190 — Predictive Biomarker (PRD): SRM mRNA
Genes: SRM; SPS1; SRML1
Study 11744907 — Surrogate Endpoint (SUR): Blood pressure
Study 25330088 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23556437 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 8613041 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 17978603 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 17978603 — Surrogate Endpoint (SUR): Blood pressure
Study 2691568 — Monitoring Biomarker (MOI): HBV DNA
Study 23726159 — Surrogate Endpoint (SUR): Blood pressure
Study 16205837 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 15458015 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 15458015 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9084062 — Predictive Biomarker (PRD): PTK7 mRNA
Genes: PTK7; CCK4
Study 26890230 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 24671049 — Surrogate Endpoint (SUR): Blood pressure
Study 11907839 — Surrogate Endpoint (SUR): Serum creatinine
Study 112944 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 112944 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 25881496 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 25881496 — Surrogate Endpoint (SUR): Blood pressure
Study 9677793 — Surrogate Endpoint (SUR): Blood pressure
Study 22900583 — Predictive Biomarker (PRD): CYP2B6 mRNA
Genes: CYP2B6
Study 22900583 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 21626525 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 23063703 — Predictive Biomarker (PRD): LHB mRNA
Genes: LHB
Study 27109630 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 14693987 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12401630 — Surrogate Endpoint (SUR): Blood pressure
Study 8547549 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 28527129 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 12060966 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 12060966 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10085710 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10085710 — Safety Biomarker (SAF): ACE
Genes: ACE1; CD143
Study 7981011 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7981011 — Surrogate Endpoint (SUR): Blood pressure
Study 14982510 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 9210004 — Predictive Biomarker (PRD): CBS mRNA
Genes: CBS
Study 29925421 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 29925421 — Surrogate Endpoint (SUR): Blood pressure
Study 22508964 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 22508964 — Surrogate Endpoint (SUR): Serum sodium
Study 11455735 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31625118 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27753739 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7964515 — Predictive Biomarker (PRD): Lymphocyte activation antigen CD30
Genes: TNFRSF8; CD30; D1S166E
Study 7964515 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 7964515 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 25493952 — Surrogate Endpoint (SUR): Blood pressure
Study 21617185 — Pharmacodynamic Biomarker (PDY): Signal transducer and activator of transcription 3
Genes: STAT3; APRF
Study 31064359 — Safety Biomarker (SAF): Hyaluronic acid
Study 26603745 — Surrogate Endpoint (SUR): Blood pressure
Study 16036495 — Surrogate Endpoint (SUR): Blood pressure
Study 735294 — Predictive Biomarker (PRD): PRCP mRNA
Genes: PRCP; PCP
Study 31083176 — Predictive Biomarker (PRD): GRIK4 mRNA
Genes: GRIK4; GRIK
Study 31083176 — Predictive Biomarker (PRD): GRM7 mRNA
Genes: GRM7; GPRC1G; MGLUR7
Study 31083176 — Predictive Biomarker (PRD): GRIA1 mRNA
Genes: GRIA1; GLUH1; GLUR1
Study 11376301 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11376301 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8685072 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 31618444 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27469482 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 18177441 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 16276071 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16276071 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 12975721 — Surrogate Endpoint (SUR): Blood pressure
Study 12975721 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10731173 — Surrogate Endpoint (SUR): Forced vital capacity
Study 20624243 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 12056293 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10692750 — Predictive Biomarker (PRD): PPEF1 mRNA
Genes: PPEF1; PPEF; PPP7C
Study 30902674 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 30902674 — Safety Biomarker (SAF): BDNF
Study 30902674 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11498313 — Surrogate Endpoint (SUR): Blood pressure
Study 16043683 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2529776 — Surrogate Endpoint (SUR): Blood pressure
Study 21507295 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19934866 — Pharmacodynamic Biomarker (PDY): Extracellular signal-regulated kinase
Study 24586994 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24586994 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20404000 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 12427413 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12427413 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26349919 — Surrogate Endpoint (SUR): Blood pressure
Study 18356605 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16206598 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16206598 — Surrogate Endpoint (SUR): Blood pressure
Study 8527283 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 8527283 — Surrogate Endpoint (SUR): Blood pressure
Study 24056905 — Surrogate Endpoint (SUR): Blood pressure
Study 19724055 — Predictive Biomarker (PRD): Liver iron
Study 9778202 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7759929 — Surrogate Endpoint (SUR): Blood pressure
Study 2407872 — Surrogate Endpoint (SUR): Blood pressure
Study 19794979 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31338807 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 21287288 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21287288 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11557835 — Surrogate Endpoint (SUR): Bone mineral density
Study 26632101 — Surrogate Endpoint (SUR): Blood pressure
Study 10824625 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 8880558 — Surrogate Endpoint (SUR): Blood pressure
Study 27184989 — Surrogate Endpoint (SUR): Blood pressure
Study 31177906 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31177906 — Predictive Biomarker (PRD): EDNRA mRNA
Genes: EDNRA; ETA; ETRA
Study 31177906 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21795455 — Surrogate Endpoint (SUR): Bone mineral density
Study 9506771 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7816418 — Predictive Biomarker (PRD): KCNH2 mRNA
Genes: KCNH2; ERG; ERG1; HERG
Study 30982223 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 30982223 — Predictive Biomarker (PRD): SLCO1B1 mRNA
Genes: SLCO1B1; LST1; OATP1B1; OATP2; OATPC; SLC21A6
Study 30982223 — Safety Biomarker (SAF): SLCO1B1
Genes: OATP-C; LST-1; OATP1B1
Study 23465178 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 19916992 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 14618095 — Surrogate Endpoint (SUR): Blood pressure
Study 11009051 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 1395911 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 16046295 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 16046295 — Predictive Biomarker (PRD): CD46 mRNA
Genes: CD46; MCP; MIC10
Study 16046295 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16046295 — Predictive Biomarker (PRD): TNFA mRNA
Genes: TNF; TNFA; TNFSF2
Study 16046295 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30477800 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 30477800 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 30065941 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 30065941 — Predictive Biomarker (PRD): DMTN mRNA
Genes: DMTN; DMT; EPB49
Study 20203161 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 20203161 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 20203161 — Surrogate Endpoint (SUR): Blood pressure
Study 7546418 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 10942064 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 10942064 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Mucin-1
Genes: MUC1; PUM
Study 8843892 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8843892 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25104497 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 7474322 — Surrogate Endpoint (SUR): Blood pressure
Study 27012728 — Surrogate Endpoint (SUR): Blood pressure
Study 27144828 — Surrogate Endpoint (SUR): Probing pocket depth
Study 24080653 — Pharmacodynamic Biomarker (PDY): Antidrug antibody
Study 23849964 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 21729881 — Predictive Biomarker (PRD): ZPR1 mRNA
Genes: ZPR1; ZNF259
Study 21729881 — Predictive Biomarker (PRD): APOA1 mRNA
Genes: APOA1
Study 21729881 — Predictive Biomarker (PRD): CYP4F2 mRNA
Genes: CYP4F2
Study 21729881 — Predictive Biomarker (PRD): SCARB1 mRNA
Genes: SCARB1; CD36L1; CLA1
Study 16448524 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16448524 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22575312 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 12064916 — Predictive Biomarker (PRD): Liver iron
Study 9793811 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 7543785 — Predictive Biomarker (PRD): FMOD mRNA
Genes: FMOD; FM; SLRR2E
Study 825895 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 28691141 — Predictive Biomarker (PRD): NFKBIA
Genes: IKBA; MAD-3; IkappaBalpha
Study 28925529 — Surrogate Endpoint (SUR): Blood pressure
Study 25504269 — Predictive Biomarker (PRD): SHD mRNA
Genes: SHD
Study 24756903 — Predictive Biomarker (PRD): IL33 mRNA
Genes: IL33; C9orf26; IL1F11; NFHEV
Study 24756903 — Predictive Biomarker (PRD): STAT5A mRNA
Genes: STAT5A; STAT5
Study 16226164 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16226164 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7576400 — Surrogate Endpoint (SUR): Blood pressure
Study 8144852 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 3018023 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 31774626 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 30683494 — Predictive Biomarker (PRD): AIP mRNA
Genes: AIP; XAP2
Study 26181174 — Predictive Biomarker (PRD): HR mRNA
Genes: HR