TrialPanorama/TrialPanorama-database huggingface dataset:
Study 31665873 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29157276 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 3840565 — Surrogate Endpoint (SUR): Serum calcium
Study 3840565 — Surrogate Endpoint (SUR): Serum creatinine
Study 29587863 — Surrogate Endpoint (SUR): Serum creatinine
Study 25068290 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 20205486 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 20205486 — Surrogate Endpoint (SUR): Serum sodium
Study 8061266 — Surrogate Endpoint (SUR): Blood pressure
Study 8061266 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 18440325 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 18440325 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8814420 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 27136316 — Surrogate Endpoint (SUR): Blood pressure
Study 22638798 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 22638798 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 19400894 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 2468859 — Surrogate Endpoint (SUR): Blood pressure
Study 12452208 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 336135 — Surrogate Endpoint (SUR): Blood pressure
Study 28615506 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 25228446 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 23235719 — Surrogate Endpoint (SUR): Blood pressure
Study 22341199 — Surrogate Endpoint (SUR): Blood pressure
Study 24490380 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 24490380 — Monitoring Biomarker (MOI): HBV DNA
Study 17130190 — Surrogate Endpoint (SUR): Blood pressure
Study 21392075 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19634955 — Predictive Biomarker (PRD): CAPS mRNA
Genes: CAPS
Study 14686958 — Surrogate Endpoint (SUR): Blood pressure
Study 14686958 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11136497 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 9576148 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 7935656 — Surrogate Endpoint (SUR): Blood pressure
Study 3229016 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3229016 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10470656 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 10470656 — Predictive Biomarker (PRD): BAX mRNA
Genes: BAX; BCL2L4
Study 25583274 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25583274 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 15260084 — Surrogate Endpoint (SUR): Blood pressure
Study 9175566 — Surrogate Endpoint (SUR): Blood pressure
Study 9175566 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1494770 — Surrogate Endpoint (SUR): Serum potassium
Study 31425580 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24722769 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 24722769 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23695772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23695772 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23695772 — Surrogate Endpoint (SUR): Blood pressure
Study 10868869 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10868869 — Surrogate Endpoint (SUR): Blood pressure
Study 22098444 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22098444 — Surrogate Endpoint (SUR): Blood pressure
Study 2471894 — Surrogate Endpoint (SUR): Blood pressure
Study 31239690 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 25111136 — Predictive Biomarker (PRD): ESD mRNA
Genes: ESD
Study 7858335 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 7858335 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2561147 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2561147 — Surrogate Endpoint (SUR): Blood pressure
Study 21315002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21315002 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21315002 — Safety Biomarker (SAF): IL-6 and IL-10
Study 15355469 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10357402 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 25261978 — Surrogate Endpoint (SUR): Blood pressure
Study 31517847 — Surrogate Endpoint (SUR): Pathological complete response
Study 25877963 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15070666 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 15070666 — Predictive Biomarker (PRD): KITLG mRNA
Genes: KITLG; MGF; SCF
Study 15070666 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 15070666 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 7837397 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 28918083 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 28918083 — Predictive Biomarker (PRD): CALML5 mRNA
Genes: CALML5; CLSP
Study 23024014 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 18064333 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 31707767 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 25142278 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 23283590 — Surrogate Endpoint (SUR): Pathological complete response
Study 21622083 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 31490429 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 31490429 — Surrogate Endpoint (SUR): Serum testosterone
Study 31501112 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 12851985 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12851985 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 30676482 — Surrogate Endpoint (SUR): Blood pressure
Study 26272720 — Surrogate Endpoint (SUR): Blood pressure
Study 21170794 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8959119 — Surrogate Endpoint (SUR): Forced vital capacity
Study 29908472 — Predictive Biomarker (PRD): DPT mRNA
Genes: DPT
Study 20423357 — Surrogate Endpoint (SUR): Blood pressure
Study 10936121 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 8737213 — Surrogate Endpoint (SUR): Blood pressure
Study 30037277 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 30037277 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 30037277 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 30037277 — Monitoring Biomarker (MOI): Matrix metalloproteinase 1
Genes: MMP1; CLG
Study 22732313 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 22732313 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 16288704 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 16288704 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 12126818 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 28087371 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 26094950 — Surrogate Endpoint (SUR): Blood pressure
Study 19240996 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 3202502 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28325148 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23683069 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18828814 — Surrogate Endpoint (SUR): Probing pocket depth
Study 31985066 — Predictive Biomarker (PRD): MBL2 mRNA
Genes: MBL2; COLEC1; MBL
Study 31985066 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 26197241 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 24818626 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24818626 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 31319908 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 1830551 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28102978 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28102978 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21883004 — Predictive Biomarker (PRD): TYMP mRNA
Genes: TYMP; ECGF1
Study 11370546 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 3034107 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 27965209 — Surrogate Endpoint (SUR): Blood pressure
Study 1430300 — Surrogate Endpoint (SUR): Blood pressure
Study 30073795 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 17012875 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 10739846 — Predictive Biomarker (PRD): MBL2 mRNA
Genes: MBL2; COLEC1; MBL
Study 23881929 — Predictive Biomarker (PRD): VHL mRNA
Genes: VHL
Study 23881929 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21241468 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21241468 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 19592748 — Predictive Biomarker (PRD): GSR mRNA
Genes: GSR; GLUR; GRD1
Study 19592748 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12574810 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 10845831 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10845831 — Surrogate Endpoint (SUR): Blood pressure
Study 1546915 — Surrogate Endpoint (SUR): Blood pressure
Study 31359800 — Surrogate Endpoint (SUR): Bone mineral density
Study 29735344 — Predictive Biomarker (PRD): VIM mRNA
Genes: VIM
Study 21347648 — Predictive Biomarker (PRD): Hormone receptor
Study 18626520 — Predictive Biomarker (PRD): RHOH mRNA
Genes: RHOH; ARHH; TTF
Study 12744878 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 10586395 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 7037047 — Surrogate Endpoint (SUR): Blood pressure
Study 29657029 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 29657029 — Predictive Biomarker (PRD): SIM1 mRNA
Genes: SIM1; BHLHE14
Study 24262513 — Surrogate Endpoint (SUR): Blood pressure
Study 24262513 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17612054 — Pharmacodynamic Biomarker (PDY): Amyloid beta peptide (1-40)
Genes: APP; A4; AD1
Study 16640173 — Surrogate Endpoint (SUR): Blood pressure
Study 1903409 — Surrogate Endpoint (SUR): Blood pressure
Study 6168124 — Surrogate Endpoint (SUR): Blood pressure
Study 31498919 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 31498919 — Surrogate Endpoint (SUR): Blood pressure
Study 2829267 — Surrogate Endpoint (SUR): Blood pressure
Study 28222641 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 26135562 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 30911578 — Monitoring Biomarker (MOI): Mitochondrial frataxin
Genes: FXN; FRDA; X25
Study 30911578 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 27439894 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 24742939 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 8843206 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25377946 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 20799005 — Surrogate Endpoint (SUR): Blood pressure
Study 25468946 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 28693998 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23811187 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 23811187 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15119171 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 8035030 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 2500141 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 10683055 — Surrogate Endpoint (SUR): Serum testosterone
Study 19945508 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 28027123 — Pharmacodynamic Biomarker (PDY): Human leukocyte antigen DR
Study 28027123 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11958301 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31568024 — Surrogate Endpoint (SUR): Blood pressure
Study 25767256 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23503548 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 23503548 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 9403648 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 16269974 — Surrogate Endpoint (SUR): Blood pressure
Study 16269974 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7747370 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 23047002 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 23047002 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 23047002 — Predictive Biomarker (PRD): GLS2 mRNA
Genes: GLS2; GA
Study 10667615 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 30761964 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23134211 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 15047649 — Predictive Biomarker (PRD): DSP mRNA
Genes: DSP
Study 9602874 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 9602874 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 9602874 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 9602874 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 9602874 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 27445067 — Safety Biomarker (SAF): Hyaluronic acid
Study 17631296 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 17631296 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 17631296 — Surrogate Endpoint (SUR): Serum triglycerides
Study 17631296 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17631296 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11230794 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2422973 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22687642 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 18477013 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 18477013 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28940323 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 22542530 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22542530 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9640146 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 7660402 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7660402 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 8357774 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8357774 — Surrogate Endpoint (SUR): Blood pressure
Study 17957184 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17957184 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29949429 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 27114605 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 27114605 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 11585083 — Surrogate Endpoint (SUR): Forced vital capacity
Study 9700123 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 2645313 — Predictive Biomarker (PRD): IHH mRNA
Genes: IHH
Study 25904366 — Surrogate Endpoint (SUR): Blood pressure
Study 25904366 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21393433 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15483415 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9084461 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 9084461 — Surrogate Endpoint (SUR): Serum calcium
Study 24427287 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 25607523 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10414674 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 31547771 — Surrogate Endpoint (SUR): Bone mineral density
Study 25586468 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 23533460 — Surrogate Endpoint (SUR): Blood pressure
Study 16717144 — Predictive Biomarker (PRD): NE
Study 16717144 — Surrogate Endpoint (SUR): Blood pressure
Study 9701429 — Surrogate Endpoint (SUR): Forced vital capacity
Study 7829780 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 27449273 — Predictive Biomarker (PRD): OPRD1 mRNA
Genes: OPRD1; OPRD
Study 20801500 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 10579471 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 8636369 — Surrogate Endpoint (SUR): Blood pressure
Study 8636369 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30850677 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 1560323 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29343256 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 26571885 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 7713274 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27206386 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 2472515 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 2472515 — Surrogate Endpoint (SUR): Blood pressure
Study 15492131 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11566622 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11566622 — Safety Biomarker (SAF): Interleukin 1
Study 29995697 — Surrogate Endpoint (SUR): Blood pressure
Study 23696687 — Predictive Biomarker (PRD): PLA1A mRNA
Genes: PLA1A; NMD; PSPLA1
Study 19507268 — Safety Biomarker (SAF): Reactive oxygen species
Study 9648550 — Safety Biomarker (SAF): DRD2
Study 4396186 — Surrogate Endpoint (SUR): Blood pressure
Study 4396186 — Surrogate Endpoint (SUR): Forced vital capacity
Study 28679449 — Predictive Biomarker (PRD): Forkhead box protein P3
Genes: FOXP3; IPEX; JM2
Study 28679449 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26596672 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23808999 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23808999 — Surrogate Endpoint (SUR): Blood pressure
Study 29180454 — Surrogate Endpoint (SUR): Blood pressure
Study 29180454 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 19712933 — Predictive Biomarker (PRD): LRP1 mRNA
Genes: LRP1; A2MR; APR
Study 19712933 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Platelet glycoprotein 4
Genes: CD36; GP3B; GP4
Study 19712933 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 19712933 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 17938573 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 31812487 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 26342731 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8018001 — Surrogate Endpoint (SUR): Blood pressure
Study 25105284 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24820145 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11306154 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4