TrialPanorama/TrialPanorama-database huggingface dataset:
Study 2497096 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 21989542 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20979784 — Surrogate Endpoint (SUR): Bone mineral density
Study 16093464 — Surrogate Endpoint (SUR): Bone mineral density
Study 31864339 — Surrogate Endpoint (SUR): Blood pressure
Study 28738008 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 25941765 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 25941765 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25941765 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 20165628 — Surrogate Endpoint (SUR): Blood pressure
Study 17445432 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 29966645 — Predictive Biomarker (PRD): PPIC mRNA
Genes: PPIC; CYPC
Study 29966645 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 22777936 — Surrogate Endpoint (SUR): Blood pressure
Study 22777936 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15735611 — Predictive Biomarker (PRD): SLCO1A2 mRNA
Genes: SLCO1A2; OATP; OATP1; OATP1A2; SLC21A3
Study 8856481 — Surrogate Endpoint (SUR): Blood pressure
Study 16682304 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 16682304 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 1854047 — Predictive Biomarker (PRD): TPR mRNA
Genes: TPR
Study 1854047 — Surrogate Endpoint (SUR): Blood pressure
Study 29181852 — Safety Biomarker (SAF): Hyaluronic acid
Study 24225449 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 12153743 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 19075055 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 11468148 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 3139571 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 15534491 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HLA-A
Study 24373369 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 24373369 — Predictive Biomarker (PRD): PGAM1 mRNA
Genes: PGAM1; PGAMA; CDABP0006
Study 24373369 — Predictive Biomarker (PRD): AZGP1 mRNA
Genes: AZGP1; ZAG; ZNGP1
Study 24373369 — Safety Biomarker (SAF): BDNF
Study 25007091 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 22311342 — Surrogate Endpoint (SUR): Blood pressure
Study 25705899 — Safety Biomarker (SAF): Coagulation factor IIa
Genes: F2
Study 11304861 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 9398099 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 28736918 — Pharmacodynamic Biomarker (PDY): Dermal blood flow
Study 24834772 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 24834772 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16012002 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30500558 — Surrogate Endpoint (SUR): Blood pressure
Study 11157331 — Pharmacodynamic Biomarker (PDY): Human leukocyte antigen DR
Study 11157331 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11157331 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15716710 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15716710 — Surrogate Endpoint (SUR): Blood pressure
Study 22549600 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 14516881 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 1987006 — Surrogate Endpoint (SUR): Blood pressure
Study 6846125 — Surrogate Endpoint (SUR): Blood pressure
Study 25623520 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25623520 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15211441 — Surrogate Endpoint (SUR): Blood pressure
Study 15211441 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15211441 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9156934 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 9156934 — Surrogate Endpoint (SUR): Blood pressure
Study 1860199 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 18156990 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12640021 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19541503 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 19541503 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20368475 — Surrogate Endpoint (SUR): Blood pressure
Study 15668361 — Surrogate Endpoint (SUR): Blood pressure
Study 12544691 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 227680 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 227680 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 19720911 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19720911 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 12185892 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 30694972 — Predictive Biomarker (PRD): REST mRNA
Genes: REST; NRSF; XBR
Study 23192919 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 23192919 — Surrogate Endpoint (SUR): Serum creatinine
Study 8674923 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 20873243 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 20873243 — Surrogate Endpoint (SUR): Blood pressure
Study 16351785 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 10361873 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 8572838 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8572838 — Surrogate Endpoint (SUR): Blood pressure
Study 8572838 — Surrogate Endpoint (SUR): Serum creatinine
Study 29310989 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29310989 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24803302 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16926662 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11304719 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31492718 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 31836949 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 31836949 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 23001685 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23001685 — Safety Biomarker (SAF): Hyaluronic acid
Study 23001685 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Matrix metalloproteinase 3
Genes: MMP3; STMY1
Study 19245735 — Surrogate Endpoint (SUR): Blood pressure
Study 10831636 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10831636 — Surrogate Endpoint (SUR): Blood pressure
Study 10831636 — Surrogate Endpoint (SUR): Serum creatinine
Study 25058680 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16109088 — Surrogate Endpoint (SUR): Bone mineral density
Study 7817807 — Surrogate Endpoint (SUR): Bone mineral density
Study 3287881 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 18288734 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 29438373 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 25706092 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18468955 — Surrogate Endpoint (SUR): Serum potassium
Study 16177196 — Surrogate Endpoint (SUR): Bone mineral density
Study 12668521 — Predictive Biomarker (PRD): GLA
Genes: GALA
Study 1839125 — Surrogate Endpoint (SUR): Blood pressure
Study 6344896 — Surrogate Endpoint (SUR): Blood pressure
Study 6344896 — Surrogate Endpoint (SUR): Serum potassium
Study 6344896 — Surrogate Endpoint (SUR): Serum uric acid
Study 27841850 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22313729 — Surrogate Endpoint (SUR): Blood pressure
Study 20377925 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20377925 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12050252 — Surrogate Endpoint (SUR): Bone mineral density
Study 26387030 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 24431462 — Predictive Biomarker (PRD): NRG3 mRNA
Genes: NRG3
Study 23440680 — Surrogate Endpoint (SUR): Serum creatinine
Study 2199721 — Surrogate Endpoint (SUR): Blood pressure
Study 24325104 — Predictive Biomarker (PRD): NGB mRNA
Genes: NGB
Study 24325104 — Predictive Biomarker (PRD): S100B mRNA
Genes: S100B
Study 19874474 — Predictive Biomarker (PRD): VKORC1 mRNA
Genes: VKORC1; VKOR; MSTP134; MSTP576; UNQ308/PRO351
Study 19874474 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 10484598 — Surrogate Endpoint (SUR): Blood pressure
Study 1672481 — Surrogate Endpoint (SUR): Blood pressure
Study 27562778 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 19687793 — Predictive Biomarker (PRD): FTO mRNA
Genes: FTO; KIAA1752
Study 12621596 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 19951850 — Surrogate Endpoint (SUR): Blood pressure
Study 9875578 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 2116311 — Surrogate Endpoint (SUR): Blood pressure
Study 21649839 — Surrogate Endpoint (SUR): Blood pressure
Study 19656039 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 6984223 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 3987791 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 27055414 — Pharmacodynamic Biomarker (PDY): Human leukocyte antigen DR
Study 20210907 — Surrogate Endpoint (SUR): Blood pressure
Study 16006259 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16006259 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 17170609 — Surrogate Endpoint (SUR): Blood pressure
Study 10766415 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 10766415 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10766415 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28285317 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 20826875 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 19220913 — Surrogate Endpoint (SUR): Blood pressure
Study 14982571 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 14982571 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 14982571 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 14982571 — Surrogate Endpoint (SUR): Blood pressure
Study 1385913 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 6429359 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 24875670 — Surrogate Endpoint (SUR): Blood pressure
Study 22997495 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 9700743 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 343992 — Surrogate Endpoint (SUR): Serum creatinine
Study 31823525 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 19
Genes: FGF19; UNQ334/PRO533
Study 25895447 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 23935969 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23935969 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 23935969 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 23935969 — Predictive Biomarker (PRD): Tubulin beta-3 chain
Genes: TUBB3; TUBB4
Study 21871987 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 16891292 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16891292 — Surrogate Endpoint (SUR): Serum triglycerides
Study 16891292 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14763913 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 22812251 — Surrogate Endpoint (SUR): Serum calcium
Study 8984866 — Surrogate Endpoint (SUR): Blood pressure
Study 15899950 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15899950 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9814729 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 9814729 — Predictive Biomarker (PRD): RNASE2 mRNA
Genes: RNASE2; EDN; RNS2
Study 31919527 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 21425378 — Predictive Biomarker (PRD): MIF mRNA
Genes: MIF; GLIF; MMIF
Study 1581012 — Surrogate Endpoint (SUR): Blood pressure
Study 1581012 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24770699 — Surrogate Endpoint (SUR): Blood pressure
Study 18415895 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 18415895 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 9258576 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 9258576 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 27051376 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 27051376 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27051376 — Surrogate Endpoint (SUR): Blood pressure
Study 18166547 — Surrogate Endpoint (SUR): Blood pressure
Study 15923670 — Monitoring Biomarker (MOI): HBV DNA
Study 10632736 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 16243997 — Surrogate Endpoint (SUR): Blood pressure
Study 10420905 — Surrogate Endpoint (SUR): Serum creatinine
Study 7776458 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28185444 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28185444 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28185444 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19421075 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 17362248 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 30511312 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30511312 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30511312 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29519502 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 19
Genes: FGF19; UNQ334/PRO533
Study 7593442 — Surrogate Endpoint (SUR): Serum testosterone
Study 2367197 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2367197 — Surrogate Endpoint (SUR): Blood pressure
Study 29624592 — Predictive Biomarker (PRD): CLDN11 mRNA
Genes: CLDN11; OSP; OTM
Study 24710336 — Surrogate Endpoint (SUR): Blood pressure
Study 20550489 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MUC5AC mRNA
Genes: MUC5AC; MUC5
Study 8570447 — Surrogate Endpoint (SUR): Blood pressure
Study 25701335 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25701335 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25701335 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21298377 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 21298377 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 7594027 — Surrogate Endpoint (SUR): Blood pressure
Study 29952247 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 18928481 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 18928481 — Predictive Biomarker (PRD): NES mRNA
Genes: NES; Nbla00170
Study 18928481 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 2485052 — Surrogate Endpoint (SUR): Blood pressure
Study 19344563 — Predictive Biomarker (PRD): NNT mRNA
Genes: NNT
Study 28219104 — Surrogate Endpoint (SUR): Blood pressure
Study 18664541 — Surrogate Endpoint (SUR): Forced vital capacity
Study 9572791 — Surrogate Endpoint (SUR): Forced vital capacity
Study 29337426 — Predictive Biomarker (PRD): CYCS mRNA
Genes: CYCS; CYC
Study 27576774 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 29085957 — Surrogate Endpoint (SUR): Bone mineral density
Study 27060082 — Predictive Biomarker (PRD): PADI2 mRNA
Genes: PADI2; KIAA0994; PAD2; PDI2
Study 27060082 — Predictive Biomarker (PRD): H3-3A mRNA
Genes: H3-3A; H3.3A; H3F3; H3F3A; PP781;; H3-3B; H3.3B; H3F3B
Study 22765322 — Predictive Biomarker (PRD): IDS mRNA
Genes: IDS; SIDS
Study 16152755 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 687500 — Surrogate Endpoint (SUR): Blood pressure
Study 2887520 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 26847148 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 25385295 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 1381763 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6371289 — Surrogate Endpoint (SUR): Blood pressure
Study 23128528 — Predictive Biomarker (PRD): O-6-methylguanine-DNA-alkyltransferase
Genes: MGMT
Study 16815320 — Surrogate Endpoint (SUR): Blood pressure
Study 7100 — Surrogate Endpoint (SUR): Blood pressure
Study 24903024 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 20456105 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase BTK
Genes: BTK; AGMX1; ATK; BPK
Study 10980853 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 24827902 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 10452142 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 10452142 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 8733874 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 17327294 — Surrogate Endpoint (SUR): Serum creatinine
Study 20175714 — Surrogate Endpoint (SUR): Blood pressure
Study 20175714 — Surrogate Endpoint (SUR): Serum creatinine
Study 12160622 — Safety Biomarker (SAF): Interleukin 12
Study 6282455 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 27860068 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 27860068 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 27860068 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 27860068 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 23395639 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 9152782 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9152782 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 675213 — Surrogate Endpoint (SUR): Blood pressure
Study 30945505 — Predictive Biomarker (PRD): SP9 mRNA
Genes: SP9
Study 21546719 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 19018239 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 19018239 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19018239 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11549646 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 11549646 — Surrogate Endpoint (SUR): Bone mineral density
Study 9542478 — Surrogate Endpoint (SUR): Blood pressure
Study 7864934 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7864934 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19401368 — Surrogate Endpoint (SUR): Bone mineral density
Study 17127797 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 2579868 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 22803422 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 11080323 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8510088 — Surrogate Endpoint (SUR): Blood pressure
Study 11473677 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 11473677 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 8495690 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 8495690 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 18672762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18672762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18672762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18672762 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2