TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23980737 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9085974 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 9085974 — Surrogate Endpoint (SUR): Serum creatinine
Study 26569364 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 26569364 — Surrogate Endpoint (SUR): Serum creatinine
Study 26569364 — Safety Biomarker (SAF): miR-423
Genes: MIR423
Study 26569364 — Safety Biomarker (SAF): miR-652
Genes: MIR652
Study 26569364 — Safety Biomarker (SAF): miR-18a-5p
Genes: MIR18A
Study 20393402 — Surrogate Endpoint (SUR): Bone mineral density
Study 25409596 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 22476643 — Predictive Biomarker (PRD); Safety Biomarker (SAF): FGA mRNA
Genes: FGA
Study 18765397 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10069786 — Surrogate Endpoint (SUR): Blood pressure
Study 28240597 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 10889153 — Safety Biomarker (SAF): BDNF
Study 1560424 — Surrogate Endpoint (SUR): Blood pressure
Study 3904336 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 22362849 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11855668 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11258648 — Predictive Biomarker (PRD): NR3C1 mRNA
Genes: NR3C1; GRL
Study 11258648 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11258648 — Predictive Biomarker (PRD): IL2
Genes: IL-2; TCGF
Study 11258648 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 11258648 — Predictive Biomarker (PRD): Interleukin 5
Genes: IL5
Study 11258648 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11258648 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 11258648 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 11258648 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11258648 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 28239907 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 23115399 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 17691581 — Safety Biomarker (SAF): Coagulation factor IIa
Genes: F2
Study 17691581 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 17691581 — Surrogate Endpoint (SUR): Serum testosterone
Study 11433050 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 15750189 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 12356779 — Surrogate Endpoint (SUR): Bone mineral density
Study 6318543 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 6318543 — Surrogate Endpoint (SUR): Blood pressure
Study 30646261 — Surrogate Endpoint (SUR): Blood pressure
Study 30646261 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31481605 — Predictive Biomarker (PRD): MARS1 mRNA
Genes: MARS1; MARS
Study 17070593 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 1884720 — Surrogate Endpoint (SUR): Blood pressure
Study 27040154 — Surrogate Endpoint (SUR): Blood pressure
Study 16011198 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 16011198 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 21189853 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 21189853 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 21189853 — Surrogate Endpoint (SUR): Blood pressure
Study 10498024 — Safety Biomarker (SAF): Hyaluronic acid
Study 24988179 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9697880 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 9697880 — Safety Biomarker (SAF): Aminopeptidase N
Genes: ANPEP; APN; CD13; PEPN
Study 9697880 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 2172394 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 1020905 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8620521 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31303526 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 29279062 — Predictive Biomarker (PRD): Forkhead box protein P3
Genes: FOXP3; IPEX; JM2
Study 29279062 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 29279062 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 24136296 — Safety Biomarker (SAF): MMP-1
Genes: MMP1
Study 30621746 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24252058 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 17951496 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Trefoil factor 3
Genes: TFF3; ITF; TFI
Study 12050266 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12050266 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 27644162 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 27644162 — Surrogate Endpoint (SUR): Blood pressure
Study 15094937 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 28228317 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 28228317 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 28228317 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15378556 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 9409267 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 9409267 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 9409267 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 9409267 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 9409267 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 25413264 — Surrogate Endpoint (SUR): Blood pressure
Study 18493214 — Predictive Biomarker (PRD): CD80 mRNA
Genes: CD80; CD28LG; CD28LG1; LAB7
Study 18493214 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 18493214 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18493214 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 15799928 — Safety Biomarker (SAF): Argininosuccinate synthase
Genes: ASS1; ASS
Study 31479209 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 22472069 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 16253098 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 30325687 — Safety Biomarker (SAF): Hyaluronic acid
Study 18062059 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 10614063 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 30922259 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26888075 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 6191130 — Surrogate Endpoint (SUR): Blood pressure
Study 29973284 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19003734 — Safety Biomarker (SAF): Reactive oxygen species
Study 3886142 — Surrogate Endpoint (SUR): Blood pressure
Study 31569012 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31569012 — Surrogate Endpoint (SUR): Sperm parameters
Study 29628009 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29628009 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 29628009 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 27538896 — Surrogate Endpoint (SUR): Blood pressure
Study 26527048 — Surrogate Endpoint (SUR): Blood pressure
Study 20008640 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 20008640 — Predictive Biomarker (PRD): Microsatellite instability
Study 16043675 — Surrogate Endpoint (SUR): Serum testosterone
Study 12427118 — Predictive Biomarker (PRD): GLA
Genes: GALA
Study 10072221 — Surrogate Endpoint (SUR): Blood pressure
Study 10072221 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10072221 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25816805 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 3513519 — Surrogate Endpoint (SUR): Blood pressure
Study 31515458 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 2468932 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2468932 — Surrogate Endpoint (SUR): Blood pressure
Study 26035255 — Predictive Biomarker (PRD): SLAMF7 mRNA
Genes: SLAMF7; CS1; UNQ576/PRO1138
Study 21288351 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 18727661 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 15323594 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 27659879 — Surrogate Endpoint (SUR): Serum creatinine
Study 31128228 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 19178965 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16484991 — Surrogate Endpoint (SUR): Blood pressure
Study 7540147 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 7540147 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 2025787 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 6617110 — Surrogate Endpoint (SUR): Blood pressure
Study 25046946 — Monitoring Biomarker (MOI): HBV DNA
Study 29901443 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 20560802 — Surrogate Endpoint (SUR): Serum creatinine
Study 17697874 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 17697874 — Surrogate Endpoint (SUR): Serum triglycerides
Study 17697874 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 17697874 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17697874 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17697874 — Surrogate Endpoint (SUR): Serum creatinine
Study 9933654 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 3156798 — Surrogate Endpoint (SUR): Blood pressure
Study 23036264 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 23036264 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 23036264 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15265423 — Predictive Biomarker (PRD): CBS mRNA
Genes: CBS
Study 15265423 — Predictive Biomarker (PRD): FURIN mRNA
Genes: FURIN; FUR; PACE; PCSK3
Study 30946888 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 29165105 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 19046107 — Predictive Biomarker (PRD): Hormone receptor
Study 8335505 — Monitoring Biomarker (MOI): HBV DNA
Study 29596950 — Predictive Biomarker (PRD): Zinc finger protein GLI1
Genes: GLI1; GLI
Study 29596950 — Surrogate Endpoint (SUR): Blood pressure
Study 12546606 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 1930768 — Surrogate Endpoint (SUR): Blood pressure
Study 31123862 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 9704688 — Surrogate Endpoint (SUR): Blood pressure
Study 9704688 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 12897178 — Safety Biomarker (SAF): Cytochrome c
Study 3698693 — Surrogate Endpoint (SUR): Blood pressure
Study 30975627 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29905969 — Surrogate Endpoint (SUR): Bone mineral density
Study 26725183 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 25168762 — Surrogate Endpoint (SUR): Blood pressure
Study 26419675 — Surrogate Endpoint (SUR): Probing pocket depth
Study 21077346 — Surrogate Endpoint (SUR): Blood pressure
Study 23642942 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23642942 — Safety Biomarker (SAF): Interleukin 1
Study 23642942 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23642942 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21942957 — Surrogate Endpoint (SUR): Blood pressure
Study 25213774 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 22715020 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 22715020 — Surrogate Endpoint (SUR): Serum calcium
Study 30527103 — Surrogate Endpoint (SUR): Blood pressure
Study 18046432 — Surrogate Endpoint (SUR): Blood pressure
Study 28545514 — Surrogate Endpoint (SUR): Blood pressure
Study 25989216 — Surrogate Endpoint (SUR): Serum triglycerides
Study 25989216 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 25989216 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18638711 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 8807731 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 8807731 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 29968397 — Predictive Biomarker (PRD): GABBR1 mRNA
Genes: GABBR1; GPRC3A
Study 31566486 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 23815538 — Surrogate Endpoint (SUR): Blood pressure
Study 21632099 — Monitoring Biomarker (MOI): Ovarian carcinoma antigen CA125
Genes: MUC16; CA125
Study 21632099 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 8689651 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8689651 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 8689651 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16903977 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16903977 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11525086 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 3129008 — Surrogate Endpoint (SUR): Blood pressure
Study 3129008 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27037553 — Predictive Biomarker (PRD): KIT mRNA
Genes: KIT; SCFR
Study 16563917 — Surrogate Endpoint (SUR): Serum sodium
Study 16002778 — Surrogate Endpoint (SUR): Blood pressure
Study 12601627 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 12601627 — Safety Biomarker (SAF): MTHFR
Study 22743678 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 12450599 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 12450599 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27796775 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 24207163 — Predictive Biomarker (PRD): PCTP mRNA
Genes: PCTP; STARD2
Study 29673620 — Surrogate Endpoint (SUR): Blood pressure
Study 21618205 — Surrogate Endpoint (SUR): Forced vital capacity
Study 29329499 — Predictive Biomarker (PRD): MAP3K10 mRNA
Genes: MAP3K10; MLK2; MST
Study 31122178 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 31122178 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 17642239 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 17642239 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28347184 — Surrogate Endpoint (SUR): Bone mineral density
Study 17566314 — Surrogate Endpoint (SUR): Blood pressure
Study 21457273 — Surrogate Endpoint (SUR): Blood pressure
Study 8739113 — Predictive Biomarker (PRD): CORT mRNA
Genes: CORT; UNQ307/PRO350
Study 31544376 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 31544376 — Surrogate Endpoint (SUR): Forced vital capacity
Study 29071848 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 30720339 — Surrogate Endpoint (SUR): Blood pressure
Study 23985432 — Surrogate Endpoint (SUR): Blood pressure
Study 8635931 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 17585665 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 16271221 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 10209075 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10209075 — Surrogate Endpoint (SUR): Blood pressure
Study 2143045 — Surrogate Endpoint (SUR): Blood pressure
Study 25832995 — Surrogate Endpoint (SUR): Blood pressure
Study 21457152 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 21457152 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 30122896 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 25531837 — Surrogate Endpoint (SUR): Blood pressure
Study 8575573 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 23110811 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 15589109 — Predictive Biomarker (PRD): GCSAM mRNA
Genes: GCSAM; GAL; GCET2
Study 11064501 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8144850 — Safety Biomarker (SAF): BCHE
Genes: E1
Study 3530442 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 9234823 — Surrogate Endpoint (SUR): Blood pressure
Study 8507449 — Surrogate Endpoint (SUR): Blood pressure
Study 22362846 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 29247383 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 17200730 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 17200730 — Predictive Biomarker (PRD): WT1 mRNA
Genes: WT1
Study 17200730 — Predictive Biomarker (PRD): IL21
Genes: Za11; IL-21
Study 17200730 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 28855223 — Surrogate Endpoint (SUR): Blood pressure
Study 26474518 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 26474518 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 21609207 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 16460241 — Predictive Biomarker (PRD): TKT mRNA
Genes: TKT
Study 15288707 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 28467869 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24655978 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 17301733 — Predictive Biomarker (PRD): SLCO1A2 mRNA
Genes: SLCO1A2; OATP; OATP1; OATP1A2; SLC21A3
Study 17301733 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 31469220 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 18822200 — Monitoring Biomarker (MOI): HBV DNA
Study 11291603 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8970679 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20428723 — Surrogate Endpoint (SUR): Blood pressure
Study 30905227 — Predictive Biomarker (PRD): TP53INP1 mRNA
Genes: TP53INP1; P53DINP1; SIP
Study 10633481 — Surrogate Endpoint (SUR): Blood pressure
Study 24038913 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 22561734 — Surrogate Endpoint (SUR): Blood pressure
Study 8669216 — Surrogate Endpoint (SUR): Blood pressure
Study 26109079 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 31693545 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 20383545 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 15841813 — Pharmacodynamic Biomarker (PDY): Salivary secretion
Study 11045792 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 30139419 — Surrogate Endpoint (SUR): Blood pressure
Study 19056575 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17634458 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17634458 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8909705 — Surrogate Endpoint (SUR): Blood pressure
Study 19350378 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19350378 — Surrogate Endpoint (SUR): Blood pressure
Study 31168845 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29521740 — Monitoring Biomarker (MOI): HBV DNA
Study 24519908 — Surrogate Endpoint (SUR): Blood pressure
Study 24519908 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19851772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 12134226 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9708400 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31587982 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31036337 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 21455591 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29112001 — Predictive Biomarker (PRD): ISM1 mRNA
Genes: ISM1; C20orf82; ISM
Study 17883958 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 17883958 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19