TrialPanorama/TrialPanorama-database huggingface dataset:
Study 9933797 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 9933797 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7398005 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 29561188 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 29561188 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 29561188 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 29561188 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 29561188 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17379124 — Surrogate Endpoint (SUR): Blood pressure
Study 10640160 — Surrogate Endpoint (SUR): Bone mineral density
Study 2287705 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 19282782 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2656070 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 29547447 — Surrogate Endpoint (SUR): Blood pressure
Study 19966072 — Surrogate Endpoint (SUR): Blood pressure
Study 30325117 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30325117 — Surrogate Endpoint (SUR): Blood pressure
Study 26381515 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 21670455 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 27655039 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 21366847 — Surrogate Endpoint (SUR): Blood pressure
Study 21069378 — Surrogate Endpoint (SUR): Blood pressure
Study 3263243 — Predictive Biomarker (PRD): HDC mRNA
Genes: HDC
Study 3263243 — Surrogate Endpoint (SUR): Blood pressure
Study 29756459 — Surrogate Endpoint (SUR): Forced vital capacity
Study 27506739 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 25609264 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 15685244 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 10574413 — Surrogate Endpoint (SUR): Blood pressure
Study 6834243 — Surrogate Endpoint (SUR): Blood pressure
Study 21166630 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18046975 — Surrogate Endpoint (SUR): Blood pressure
Study 18046975 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9186075 — Predictive Biomarker (PRD): RAPGEF5 mRNA
Genes: RAPGEF5; GFR; KIAA0277; MRGEF
Study 9186075 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 2413300 — Surrogate Endpoint (SUR): Blood pressure
Study 22399518 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 7906300 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25056158 — Surrogate Endpoint (SUR): Blood pressure
Study 23263204 — Surrogate Endpoint (SUR): Blood pressure
Study 19243712 — Surrogate Endpoint (SUR): Blood pressure
Study 25149549 — Predictive Biomarker (PRD): IRF4 mRNA
Genes: IRF4; MUM1
Study 25149549 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 19417195 — Surrogate Endpoint (SUR): Blood pressure
Study 7712526 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 30816665 — Safety Biomarker (SAF): Reactive oxygen species
Study 30816665 — Pharmacodynamic Biomarker (PDY): Mitochondrial membrane potential
Study 19243324 — Predictive Biomarker (PRD): BAG3 mRNA
Genes: BAG3; BIS
Study 19243324 — Surrogate Endpoint (SUR): Blood pressure
Study 7977713 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 26130740 — Surrogate Endpoint (SUR): Blood pressure
Study 23623280 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 11912281 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 2189448 — Surrogate Endpoint (SUR): Blood pressure
Study 20039806 — Predictive Biomarker (PRD): IVNS1ABP mRNA
Genes: IVNS1ABP; ARA3; FLARA3; KIAA0850; KLHL39; NS1; NS1BP; HSPC068
Study 1733432 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 31730458 — Predictive Biomarker (PRD): CCR5 mRNA
Genes: CCR5; CMKBR5
Study 23787544 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 23787544 — Surrogate Endpoint (SUR): Serum calcium
Study 23787544 — Surrogate Endpoint (SUR): Serum phosphate
Study 16430539 — Surrogate Endpoint (SUR): Blood pressure
Study 15577771 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30646291 — Surrogate Endpoint (SUR): Blood pressure
Study 20152243 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20152243 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8775644 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8775644 — Predictive Biomarker (PRD): RPE mRNA
Genes: RPE; HUSSY-17
Study 29577324 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 21935705 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 17438307 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 17438307 — Surrogate Endpoint (SUR): Blood pressure
Study 9923581 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 25466664 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25466664 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17166332 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 3083718 — Surrogate Endpoint (SUR): Blood pressure
Study 21604211 — Surrogate Endpoint (SUR): Bone mineral density
Study 1683336 — Surrogate Endpoint (SUR): Blood pressure
Study 31862762 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31862762 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18458872 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 10155556 — Predictive Biomarker (PRD): CYCS mRNA
Genes: CYCS; CYC
Study 10155556 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 26252875 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 18623043 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 9448150 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 328034 — Surrogate Endpoint (SUR): Serum uric acid
Study 27381900 — Predictive Biomarker (PRD): PRKAG2 mRNA
Genes: PRKAG2
Study 27381900 — Predictive Biomarker (PRD): DCC mRNA
Genes: DCC; IGDCC1
Study 27381900 — Predictive Biomarker (PRD): EPHX2 mRNA
Genes: EPHX2
Study 15840042 — Surrogate Endpoint (SUR): Serum creatinine
Study 10063787 — Surrogate Endpoint (SUR): Blood pressure
Study 7586339 — Surrogate Endpoint (SUR): Blood pressure
Study 375959 — Surrogate Endpoint (SUR): Blood pressure
Study 30735751 — Predictive Biomarker (PRD): NFE2 mRNA
Genes: NFE2
Study 30735751 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 28795473 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 28795473 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 28795473 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 18156171 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 9647412 — Surrogate Endpoint (SUR): Blood pressure
Study 29705218 — Predictive Biomarker (PRD): NANOS3 mRNA
Genes: NANOS3; NOS3
Study 22492370 — Surrogate Endpoint (SUR): Blood pressure
Study 9657623 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9657623 — Surrogate Endpoint (SUR): Blood pressure
Study 31276312 — Safety Biomarker (SAF): Hyaluronic acid
Study 31299617 — Predictive Biomarker (PRD): DMA mRNA
Genes: DMA; HLA-DMA; hCG_2001572
Study 25888263 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 22159929 — Surrogate Endpoint (SUR): Forced vital capacity
Study 19806797 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 16915750 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16915750 — Surrogate Endpoint (SUR): Blood pressure
Study 19737963 — Surrogate Endpoint (SUR): Serum calcium
Study 15572534 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 12955551 — Surrogate Endpoint (SUR): Blood pressure
Study 29262859 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 21487851 — Surrogate Endpoint (SUR): Serum potassium
Study 16549964 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16549964 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 16549964 — Predictive Biomarker (PRD): CD27 mRNA
Genes: CD27; TNFRSF7
Study 16549964 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12704305 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 10924705 — Pharmacodynamic Biomarker (PDY): Huntingtin
Genes: HTT; HD; IT15
Study 24438512 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 22984506 — Predictive Biomarker (PRD): G6PC2 mRNA
Genes: G6PC2; IGRP
Study 22984506 — Predictive Biomarker (PRD): GCKR mRNA
Genes: GCKR
Study 22984506 — Predictive Biomarker (PRD): ADCY5 mRNA
Genes: ADCY5
Study 19448234 — Surrogate Endpoint (SUR): Blood pressure
Study 17092845 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 14653084 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 14653084 — Surrogate Endpoint (SUR): Blood pressure
Study 1908864 — Surrogate Endpoint (SUR): Serum creatinine
Study 1908864 — Surrogate Endpoint (SUR): Blood pressure
Study 10613615 — Surrogate Endpoint (SUR): Blood pressure
Study 22466329 — Monitoring Biomarker (MOI): HBV DNA
Study 16112720 — Surrogate Endpoint (SUR): Blood pressure
Study 12161475 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 12161475 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7575695 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7575695 — Safety Biomarker (SAF): Interleukin 1
Study 7575695 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7823520 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 28327893 — Predictive Biomarker (PRD): Apoptosis regulator Bcl-2
Genes: BCL2
Study 28327893 — Predictive Biomarker (PRD): MYC mRNA
Genes: MYC; BHLHE39
Study 24170102 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 14551147 — Safety Biomarker (SAF): Vitamin K-dependent protein C
Genes: PROC
Study 11216928 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24703167 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24703167 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24703167 — Safety Biomarker (SAF): Interleukin 1
Study 24703167 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15131005 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15131005 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11588449 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 11588449 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11588449 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11588449 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 19770386 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 17803818 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26062880 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 23385647 — Surrogate Endpoint (SUR): Blood pressure
Study 21248328 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 17125603 — Monitoring Biomarker (MOI): HBV DNA
Study 14512778 — Surrogate Endpoint (SUR): Blood pressure
Study 26077795 — Surrogate Endpoint (SUR): Blood pressure
Study 20969601 — Surrogate Endpoint (SUR): Serum testosterone
Study 19004202 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 3518384 — Surrogate Endpoint (SUR): Blood pressure
Study 15930018 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 10965085 — Surrogate Endpoint (SUR): Blood pressure
Study 1996588 — Surrogate Endpoint (SUR): Blood pressure
Study 23272061 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 20386343 — Surrogate Endpoint (SUR): Bone mineral density
Study 8621010 — Predictive Biomarker (PRD): Indoleamine 2,3-dioxygenase 1
Genes: IDO1; IDO; INDO
Study 12349828 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 12349828 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 12349828 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 12349828 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 2136974 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 19787787 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 11812272 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 11812272 — Surrogate Endpoint (SUR): Blood pressure
Study 29781941 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27797709 — Safety Biomarker (SAF): Protein AMBP
Genes: AMBP; HCP; ITIL
Study 27797709 — Surrogate Endpoint (SUR): Blood pressure
Study 27797709 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 9211127 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 9211127 — Predictive Biomarker (PRD): POMC mRNA
Genes: POMC
Study 31976814 — Surrogate Endpoint (SUR): Serum uric acid
Study 1385972 — Predictive Biomarker (PRD): TPR mRNA
Genes: TPR
Study 30738171 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 30738171 — Predictive Biomarker (PRD): Small-inducible cytokine A11
Genes: CCL11; SCYA11
Study 30738171 — Predictive Biomarker (PRD): CCL17 mRNA
Genes: CCL17; SCYA17; TARC
Study 30738171 — Predictive Biomarker (PRD): S100A12 mRNA
Genes: S100A12
Study 27026087 — Surrogate Endpoint (SUR): Blood pressure
Study 15932638 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 8573430 — Surrogate Endpoint (SUR): Bone mineral density
Study 392743 — Predictive Biomarker (PRD): MYC mRNA
Genes: MYC; BHLHE39
Study 14975474 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31948641 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18670219 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7861015 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16842799 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 16842799 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 18094675 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18094675 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 18094675 — Surrogate Endpoint (SUR): Serum creatinine
Study 12943123 — Predictive Biomarker (PRD): TERT mRNA
Genes: TERT; EST2; TCS1; TRT
Study 7513437 — Surrogate Endpoint (SUR): Serum testosterone
Study 18528796 — Surrogate Endpoint (SUR): Blood pressure
Study 18528796 — Surrogate Endpoint (SUR): Serum triglycerides
Study 23891275 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 23891275 — Predictive Biomarker (PRD): LCAT mRNA
Genes: LCAT
Study 23891275 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 17715118 — Surrogate Endpoint (SUR): Serum creatinine
Study 17715118 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 22277556 — Surrogate Endpoint (SUR): Blood pressure
Study 22277556 — Safety Biomarker (SAF): MTHFR
Study 31857511 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2446056 — Surrogate Endpoint (SUR): Blood pressure
Study 25376790 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25376790 — Predictive Biomarker (PRD): Hormone receptor
Study 12612979 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10697305 — Surrogate Endpoint (SUR): Blood pressure
Study 20706157 — Predictive Biomarker (PRD): GAST mRNA
Genes: GAST; GAS
Study 14748937 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 9606842 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 9606842 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 27079708 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 24760352 — Surrogate Endpoint (SUR): Serum sodium
Study 15802773 — Surrogate Endpoint (SUR): Bone mineral density
Study 30442422 — Surrogate Endpoint (SUR): Blood pressure
Study 30442422 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28359339 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 28359339 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 28359339 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 22015451 — Safety Biomarker (SAF): Glucose-6-phosphate dehydrogenase
Genes: G6PD
Study 24851689 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24851689 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18401016 — Predictive Biomarker (PRD): TLR7 mRNA
Genes: TLR7; UNQ248/PRO285
Study 18401016 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): C-X-C motif chemokine 9
Genes: CXCL9; CMK; MIG; SCYB9
Study 18401016 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 18401016 — Predictive Biomarker (PRD): OAS3 mRNA
Genes: OAS3; P/OKcl.4
Study 9075595 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9075595 — Surrogate Endpoint (SUR): Blood pressure
Study 27329657 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24576533 — Predictive Biomarker (PRD): PLEKHA6 mRNA
Genes: PLEKHA6; KIAA0969; PEPP3
Study 15768813 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 25624196 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 22769438 — Predictive Biomarker (PRD): HAL mRNA
Genes: HAL; HIS
Study 11814098 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 11814098 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19617841 — Surrogate Endpoint (SUR): Blood pressure
Study 17179052 — Predictive Biomarker (PRD): GLA
Genes: GALA
Study 31272592 — Predictive Biomarker (PRD): GLS mRNA
Genes: GLS; GLS1; KIAA0838
Study 26048382 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 26048382 — Surrogate Endpoint (SUR): Serum creatinine
Study 19190915 — Predictive Biomarker (PRD): HYLS1 mRNA
Genes: HYLS1; HLS
Study 19190915 — Predictive Biomarker (PRD): HGS mRNA
Genes: HGS; HRS
Study 16763099 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SLC2A4 mRNA
Genes: SLC2A4; GLUT4
Study 24227358 — Surrogate Endpoint (SUR): Serum sodium
Study 8165608 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 8165608 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 8165608 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 8165608 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 3533454 — Surrogate Endpoint (SUR): Blood pressure
Study 3533454 — Surrogate Endpoint (SUR): Forced vital capacity
Study 27715335 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24255993 — Surrogate Endpoint (SUR): Probing pocket depth
Study 2081275 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 28716236 — Surrogate Endpoint (SUR): Blood pressure
Study 24955812 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 27376466 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27376466 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 27376466 — Predictive Biomarker (PRD): CCL20 mRNA
Genes: CCL20; LARC; MIP3A; SCYA20
Study 27376466 — Predictive Biomarker (PRD): CXCL2 mRNA
Genes: CXCL2; GRO2; GROB; MIP2A; SCYB2
Study 27376466 — Safety Biomarker (SAF): C-X-C motif chemokine 5
Genes: CXCL5; ENA78; SCYB5
Study 26380439 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15193680 — Surrogate Endpoint (SUR): Blood pressure
Study 15193680 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9247776 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 2655692 — Surrogate Endpoint (SUR): Blood pressure
Study 15599840 — Surrogate Endpoint (SUR): Blood pressure
Study 1895958 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 26069949 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 22919307 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 22919307 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22919307 — Surrogate Endpoint (SUR): Serum uric acid
Study 17633796 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9667268 — Predictive Biomarker (PRD): EFS mRNA
Genes: EFS; CASS3
Study 17357049 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 15529558 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 17192290 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 17192290 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 17192290 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17192290 — Safety Biomarker (SAF): IL-6 and IL-10
Study 14700518 — Surrogate Endpoint (SUR): Blood pressure
Study 12469919 — Surrogate Endpoint (SUR): Bone mineral density