TrialPanorama/TrialPanorama-database huggingface dataset:
Study 15041604 — Pharmacodynamic Biomarker (PDY): T-lymphocyte activation antigen CD86
Genes: CD86; CD28LG2
Study 15041604 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15041604 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 15041604 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 15041604 — Pharmacodynamic Biomarker (PDY): Human leukocyte antigen DR
Study 15041604 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24974051 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 24974051 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 22091929 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 9646651 — Surrogate Endpoint (SUR): Blood pressure
Study 26911949 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 26911949 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 16600998 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 24815101 — Surrogate Endpoint (SUR): Blood pressure
Study 9180238 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27999883 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 26465928 — Surrogate Endpoint (SUR): Blood pressure
Study 9225366 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 28056021 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 15569141 — Surrogate Endpoint (SUR): Blood pressure
Study 31915189 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 31915189 — Predictive Biomarker (PRD): GFAP mRNA
Genes: GFAP
Study 28515160 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 21269402 — Surrogate Endpoint (SUR): Serum testosterone
Study 17586417 — Surrogate Endpoint (SUR): Blood pressure
Study 7900078 — Predictive Biomarker (PRD): PF4 mRNA
Genes: PF4; CXCL4; SCYB4
Study 21974760 — Surrogate Endpoint (SUR): Blood pressure
Study 3310776 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30306604 — Predictive Biomarker (PRD): TPO mRNA
Genes: TPO
Study 26541435 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 19297565 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 15573278 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 11770837 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 2452456 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 31913927 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 31373737 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 21059888 — Predictive Biomarker (PRD): ADAM17 mRNA
Genes: ADAM17; CSVP; TACE
Study 21059888 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 3026106 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 31724083 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27226338 — Surrogate Endpoint (SUR): Blood pressure
Study 24950747 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 24950747 — Predictive Biomarker (PRD): CRHR1 mRNA
Genes: CRHR1; CRFR; CRFR1; CRHR
Study 16182706 — Surrogate Endpoint (SUR): Serum creatinine
Study 25758100 — Surrogate Endpoint (SUR): Probing pocket depth
Study 9042093 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 9042093 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 2468891 — Surrogate Endpoint (SUR): Blood pressure
Study 30711247 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 27313412 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 27313412 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 27313412 — Surrogate Endpoint (SUR): Blood pressure
Study 17057415 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17057415 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 17057415 — Surrogate Endpoint (SUR): Blood pressure
Study 29660956 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25641556 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 14616411 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 7955820 — Surrogate Endpoint (SUR): Blood pressure
Study 31646707 — Surrogate Endpoint (SUR): Blood pressure
Study 16988064 — Surrogate Endpoint (SUR): Serum creatinine
Study 21152005 — Predictive Biomarker (PRD): ETV6 mRNA
Genes: ETV6; TEL; TEL1
Study 21152005 — Predictive Biomarker (PRD): RUNX1 mRNA
Genes: RUNX1; AML1; CBFA2
Study 21152005 — Predictive Biomarker (PRD): GGH mRNA
Genes: GGH
Study 21152005 — Predictive Biomarker (PRD): TCF3 mRNA
Genes: TCF3; BHLHB21; E2A; ITF1
Study 21152005 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 31917762 — Surrogate Endpoint (SUR): Serum creatinine
Study 31917762 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 28667678 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28667678 — Predictive Biomarker (PRD): TNFRSF11A mRNA
Genes: TNFRSF11A; RANK
Study 28667678 — Predictive Biomarker (PRD): TNFRSF11B mRNA
Genes: TNFRSF11B; OCIF; OPG
Study 15660024 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15660024 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11844644 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 17711714 — Predictive Biomarker (PRD): CYP1A1 mRNA
Genes: CYP1A1
Study 31889231 — Predictive Biomarker (PRD): GLA
Genes: GALA
Study 21696934 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 26762908 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 26762908 — Surrogate Endpoint (SUR): Serum creatinine
Study 18503905 — Surrogate Endpoint (SUR): Blood pressure
Study 26611525 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 26611525 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26611525 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 26611525 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 12234700 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 9664953 — Surrogate Endpoint (SUR): Serum creatinine
Study 31722150 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 21640214 — Surrogate Endpoint (SUR): Bone mineral density
Study 3306493 — Surrogate Endpoint (SUR): Blood pressure
Study 18982784 — Predictive Biomarker (PRD): ABHD14B mRNA
Genes: ABHD14B; CIB
Study 8832536 — Surrogate Endpoint (SUR): Blood pressure
Study 7490154 — Surrogate Endpoint (SUR): Blood pressure
Study 15811480 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7497867 — Surrogate Endpoint (SUR): Blood pressure
Study 16054474 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16054474 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1836894 — Surrogate Endpoint (SUR): Blood pressure
Study 26459355 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 8209272 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 28437161 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 7847611 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 7847611 — Predictive Biomarker (PRD): POMC mRNA
Genes: POMC
Study 14624369 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 14624369 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 14624369 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 17251982 — Safety Biomarker (SAF): SLCO1B1
Genes: OATP-C; LST-1; OATP1B1
Study 11967516 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 3233720 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 23549037 — Predictive Biomarker (PRD): DNA excision repair protein ERCC-1
Genes: ERCC1
Study 23549037 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 16298751 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16298751 — Surrogate Endpoint (SUR): Blood pressure
Study 11881102 — Surrogate Endpoint (SUR): Blood pressure
Study 9683207 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25070545 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 20669576 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 12420194 — Surrogate Endpoint (SUR): Blood pressure
Study 30922760 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 15446522 — Predictive Biomarker (PRD): CSRP3 mRNA
Genes: CSRP3; CLP; MLP
Study 2356344 — Surrogate Endpoint (SUR): Blood pressure
Study 22257013 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 20356440 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10375057 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 4027129 — Surrogate Endpoint (SUR): Blood pressure
Study 27327862 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 20415915 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 10947134 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 6371226 — Surrogate Endpoint (SUR): Blood pressure
Study 17991116 — Predictive Biomarker (PRD): SPARC mRNA
Genes: SPARC; ON
Study 12170527 — Surrogate Endpoint (SUR): Bone mineral density
Study 23845200 — Predictive Biomarker (PRD): PPT1 mRNA
Genes: PPT1; CLN1; PPT
Study 16403592 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16403592 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9377069 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 23363776 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12502991 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11220522 — Surrogate Endpoint (SUR): Blood pressure
Study 8695089 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 7949749 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 26414380 — Surrogate Endpoint (SUR): Blood pressure
Study 21124326 — Surrogate Endpoint (SUR): Blood pressure
Study 21124326 — Surrogate Endpoint (SUR): Serum creatinine
Study 21124326 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19145003 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19145003 — Surrogate Endpoint (SUR): Serum creatinine
Study 17925548 — Predictive Biomarker (PRD): Multidrug resistance protein 1
Genes: ABCB1; MDR1; PGY1
Study 17925548 — Predictive Biomarker (PRD): ABCC1 mRNA
Genes: ABCC1; MRP; MRP1
Study 17925548 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MRP2
Genes: ABCC2; DJS; cMRP
Study 17925548 — Predictive Biomarker (PRD): ABCG2 mRNA
Genes: ABCG2; ABCP; BCRP; BCRP1; MXR
Study 17925548 — Safety Biomarker (SAF): Cyclin-dependent kinase inhibitor 1
Genes: CDKN1A
Study 17925548 — Predictive Biomarker (PRD): CYP1B1 mRNA
Genes: CYP1B1
Study 17925548 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 17925548 — Predictive Biomarker (PRD): CYP3A5 mRNA
Genes: CYP3A5
Study 17925548 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 17925548 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Cellular tumor antigen p53
Genes: TP53; P53
Study 17925548 — Predictive Biomarker (PRD): DNA excision repair protein ERCC-1
Genes: ERCC1
Study 23972540 — Predictive Biomarker (PRD): BTC mRNA
Genes: BTC
Study 18326222 — Predictive Biomarker (PRD): PCSK7 mRNA
Genes: PCSK7; LPC; PC7; PC8; SPC7
Study 11117090 — Surrogate Endpoint (SUR): Blood pressure
Study 22336473 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 12037225 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 12037225 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 7783062 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 28658251 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 20433806 — Predictive Biomarker (PRD): TLR7 mRNA
Genes: TLR7; UNQ248/PRO285
Study 22865902 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22865902 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22865902 — Surrogate Endpoint (SUR): Blood pressure
Study 17680909 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 9757887 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 25125488 — Surrogate Endpoint (SUR): Blood pressure
Study 8764356 — Surrogate Endpoint (SUR): Blood pressure
Study 2063855 — Surrogate Endpoint (SUR): Serum creatinine
Study 2063855 — Surrogate Endpoint (SUR): Blood pressure
Study 24998880 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 20436354 — Surrogate Endpoint (SUR): Blood pressure
Study 20436354 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20436354 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10730228 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 8931411 — Monitoring Biomarker (MOI): HBV DNA
Study 29583081 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 29583081 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21568143 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 10355414 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 11163738 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11163738 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 9052467 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 20516031 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16092581 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 12585148 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 12585148 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30971236 — Predictive Biomarker (PRD): FECH mRNA
Genes: FECH
Study 11300446 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24625229 — Safety Biomarker (SAF): Hyaluronic acid
Study 1526683 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18069598 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7070229 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 19398463 — Surrogate Endpoint (SUR): Blood pressure
Study 19638921 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 11022827 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9002496 — Surrogate Endpoint (SUR): Serum uric acid
Study 28610945 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29193711 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 26218934 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 22801961 — Predictive Biomarker (PRD): Myeloid cell surface antigen CD33
Genes: CD33; SIGLEC3
Study 1378116 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 1378116 — Surrogate Endpoint (SUR): Blood pressure
Study 19260323 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15870588 — Surrogate Endpoint (SUR): Blood pressure
Study 1614196 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 30335070 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 8783774 — Surrogate Endpoint (SUR): Blood pressure
Study 1629891 — Surrogate Endpoint (SUR): Blood pressure
Study 6148867 — Surrogate Endpoint (SUR): Blood pressure
Study 30284586 — Surrogate Endpoint (SUR): Blood pressure
Study 25876348 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 25876348 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 18781486 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18781486 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 12904084 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 9414541 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 8017473 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8017473 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31408838 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 27462804 — Predictive Biomarker (PRD): DMD
Genes: BMD; DXS142; DXS164; DXS206; DXS230; DXS239; DXS268; DXS269; DXS270; DXS272
Study 27462804 — Surrogate Endpoint (SUR): Bone mineral density
Study 23819224 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25605862 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 23668423 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12575552 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 12575552 — Surrogate Endpoint (SUR): Blood pressure
Study 8162926 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 8162926 — Surrogate Endpoint (SUR): Blood pressure
Study 31179316 — Surrogate Endpoint (SUR): Blood pressure
Study 11065222 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25707083 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 10588611 — Safety Biomarker (SAF): Reactive oxygen species
Study 6765920 — Surrogate Endpoint (SUR): Blood pressure
Study 12750578 — Surrogate Endpoint (SUR): Bone mineral density
Study 10722768 — Surrogate Endpoint (SUR): Forced vital capacity
Study 3798420 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 3798420 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 16173886 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 15624040 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 15624040 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11715353 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11715353 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11715353 — Surrogate Endpoint (SUR): Blood pressure
Study 3619222 — Surrogate Endpoint (SUR): Blood pressure
Study 23866725 — Surrogate Endpoint (SUR): Blood pressure
Study 11049909 — Surrogate Endpoint (SUR): Blood pressure
Study 3898418 — Surrogate Endpoint (SUR): Blood pressure
Study 26996246 — Surrogate Endpoint (SUR): Blood pressure
Study 26286610 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 17408389 — Predictive Biomarker (PRD): PVR mRNA
Genes: PVR; PVS
Study 31439584 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 25664051 — Surrogate Endpoint (SUR): Blood pressure
Study 20125103 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 1959515 — Surrogate Endpoint (SUR): Blood pressure
Study 31099485 — Surrogate Endpoint (SUR): Forced vital capacity
Study 7752591 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7752591 — Surrogate Endpoint (SUR): Blood pressure
Study 1800749 — Surrogate Endpoint (SUR): Blood pressure
Study 6356326 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 31727580 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31240811 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 25273547 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 23783097 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 23783097 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 19
Genes: FGF19; UNQ334/PRO533
Study 23783097 — Predictive Biomarker (PRD): FGF21 mRNA
Genes: FGF21; UNQ3115/PRO10196
Study 2975228 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18793563 — Surrogate Endpoint (SUR): Blood pressure
Study 3032827 — Surrogate Endpoint (SUR): Blood pressure
Study 29447076 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 22998182 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 20003398 — Predictive Biomarker (PRD): MCIDAS mRNA
Genes: MCIDAS; IDAS; MCI; MCIN
Study 28211216 — Surrogate Endpoint (SUR): Blood pressure
Study 24063830 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 24063830 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 24816725 — Predictive Biomarker (PRD): TLR9
Genes: CD289
Study 22288389 — Monitoring Biomarker (MOI): Matrix metalloproteinase 1
Genes: MMP1; CLG
Study 12131543 — Surrogate Endpoint (SUR): Blood pressure
Study 7010529 — Surrogate Endpoint (SUR): Blood pressure
Study 30644838 — Predictive Biomarker (PRD): FXYD1 mRNA
Genes: FXYD1; PLM
Study 3356083 — Surrogate Endpoint (SUR): Blood pressure
Study 28737966 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 26694228 — Pharmacodynamic Biomarker (PDY): 5'-AMP-activated protein kinase subunit beta-1
Genes: PRKAB1; AMPK
Study 22791090 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22791090 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 22791090 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 22791090 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 22791090 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 11095440 — Surrogate Endpoint (SUR): Bone mineral density
Study 8820895 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 8820895 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 11907418 — Surrogate Endpoint (SUR): Blood pressure
Study 1964580 — Surrogate Endpoint (SUR): Blood pressure
Study 1964580 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22570108 — Surrogate Endpoint (SUR): Blood pressure
Study 18946418 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 14713377 — Predictive Biomarker (PRD): DCD mRNA
Genes: DCD; AIDD; DSEP
Study 31975558 — Predictive Biomarker (PRD): NLRP3 mRNA
Genes: NLRP3; C1orf7; CIAS1; NALP3; PYPAF1
Study 31975558 — Predictive Biomarker (PRD): PINK1 mRNA
Genes: PINK1
Study 31975558 — Predictive Biomarker (PRD): LAMP2 mRNA
Genes: LAMP2
Study 15983524 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8866563 — Predictive Biomarker (PRD): SI mRNA
Genes: SI