TrialPanorama/TrialPanorama-database huggingface dataset:
Study 25527767 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25527767 — Safety Biomarker (SAF): Reactive oxygen species
Study 21248359 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 21248359 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21248359 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Metalloproteinase inhibitor 1
Genes: TIMP1; CLGI; TIMP
Study 21248359 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 15131566 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 3124478 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 23208159 — Predictive Biomarker (PRD): SAT1 mRNA
Genes: SAT1; SAT
Study 19015206 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17468442 — Predictive Biomarker (PRD): MTR mRNA
Genes: MTR
Study 15947332 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 15947332 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11913407 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7986853 — Predictive Biomarker (PRD): LCT mRNA
Genes: LCT; LPH
Study 26210844 — Predictive Biomarker (PRD): RITA1 mRNA
Genes: RITA1; C12orf52; RITA; PSEC0043
Study 19232412 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14666761 — Surrogate Endpoint (SUR): Serum testosterone
Study 9029411 — Pharmacodynamic Biomarker (PDY): Homovanillic acid
Study 1377457 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 26476404 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 26476404 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 26476404 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 20565455 — Surrogate Endpoint (SUR): Serum potassium
Study 1574019 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 17434401 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2276191 — Surrogate Endpoint (SUR): Blood pressure
Study 19209073 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15187195 — Surrogate Endpoint (SUR): Serum calcium
Study 14693300 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 1848072 — Surrogate Endpoint (SUR): Blood pressure
Study 30522501 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30522501 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18570597 — Surrogate Endpoint (SUR): Blood pressure
Study 18570597 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18570597 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 18570597 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10578972 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 1654365 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 21446902 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30200092 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 30200092 — Predictive Biomarker (PRD): Hormone receptor
Study 12740742 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 11116697 — Predictive Biomarker (PRD): DHPS mRNA
Genes: DHPS; DS
Study 11116697 — Predictive Biomarker (PRD): GNL3 mRNA
Genes: GNL3; E2IG3; NS
Study 27538513 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 27538513 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 23644549 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23644549 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18381571 — Surrogate Endpoint (SUR): Bone mineral density
Study 10777986 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9208626 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 28122280 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 16816537 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16816537 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 28221010 — Safety Biomarker (SAF): Cardiac troponin T
Genes: TNNT2
Study 21128114 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 14977438 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 6124859 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 29356608 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 26757989 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21248779 — Surrogate Endpoint (SUR): Blood pressure
Study 17516829 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 15738542 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 2200384 — Surrogate Endpoint (SUR): Blood pressure
Study 31221944 — Safety Biomarker (SAF): Hyaluronic acid
Study 21190036 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 21190036 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12616435 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12616435 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10979060 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 30197273 — Predictive Biomarker (PRD): PNPLA3 mRNA
Genes: PNPLA3; ADPN; C22orf20
Study 30197273 — Surrogate Endpoint (SUR): Serum triglycerides
Study 23041591 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 1462864 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1462864 — Surrogate Endpoint (SUR): Blood pressure
Study 29428315 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 7000172 — Surrogate Endpoint (SUR): Blood pressure
Study 30877937 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 30877937 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 23442944 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 21196617 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21196617 — Surrogate Endpoint (SUR): Blood pressure
Study 21196617 — Surrogate Endpoint (SUR): Serum potassium
Study 19480864 — Predictive Biomarker (PRD): MME mRNA
Genes: MME; EPN
Study 14995946 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 3180119 — Surrogate Endpoint (SUR): Blood pressure
Study 28104514 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 17190893 — Surrogate Endpoint (SUR): Bone mineral density
Study 1543796 — Surrogate Endpoint (SUR): Blood pressure
Study 29475121 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 29475121 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23313811 — Predictive Biomarker (PRD): CD22 mRNA
Genes: CD22; SIGLEC2
Study 10482309 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 10482309 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 25986447 — Surrogate Endpoint (SUR): Serum uric acid
Study 24867069 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26092388 — Predictive Biomarker (PRD): SIT1 mRNA
Genes: SIT1; SIT
Study 23220080 — Predictive Biomarker (PRD): KLK5 mRNA
Genes: KLK5; SCTE; UNQ570/PRO1132
Study 23220080 — Predictive Biomarker (PRD): KLK7 mRNA
Genes: KLK7; PRSS6; SCCE
Study 9264494 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9264494 — Surrogate Endpoint (SUR): Blood pressure
Study 3107444 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 10418844 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 7015262 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 29995456 — Predictive Biomarker (PRD): MEF2C mRNA
Genes: MEF2C
Study 29995456 — Predictive Biomarker (PRD): PGC mRNA
Genes: PGC
Study 24908551 — Surrogate Endpoint (SUR): Serum creatinine
Study 17497471 — Surrogate Endpoint (SUR): Bone mineral density
Study 11246837 — Surrogate Endpoint (SUR): Blood pressure
Study 3322826 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28628810 — Predictive Biomarker (PRD): SAT1 mRNA
Genes: SAT1; SAT
Study 23648162 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 8642803 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 8642803 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8642803 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26790204 — Predictive Biomarker (PRD): PTGDS mRNA
Genes: PTGDS; PDS
Study 22743378 — Surrogate Endpoint (SUR): Blood pressure
Study 15333722 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Mitochondrial DNA
Study 11587988 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 29884231 — Surrogate Endpoint (SUR): Blood pressure
Study 25865041 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26707905 — Predictive Biomarker (PRD): AMH mRNA
Genes: AMH; MIF
Study 1552711 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 27065462 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27065462 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19910928 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19910928 — Surrogate Endpoint (SUR): Blood pressure
Study 9849982 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 31918233 — Predictive Biomarker (PRD): STS mRNA
Genes: STS; ARSC1
Study 16709309 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16709309 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16709309 — Surrogate Endpoint (SUR): Blood pressure
Study 11401659 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 22752356 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 20131039 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 20131039 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 20131039 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 17493508 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17493508 — Surrogate Endpoint (SUR): Blood pressure
Study 8958491 — Surrogate Endpoint (SUR): Blood pressure
Study 31415133 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31415133 — Surrogate Endpoint (SUR): Blood pressure
Study 23303198 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23303198 — Surrogate Endpoint (SUR): Blood pressure
Study 16920847 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 10999649 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 10999649 — Surrogate Endpoint (SUR): Blood pressure
Study 31522033 — Predictive Biomarker (PRD): FGF2 mRNA
Genes: FGF2; FGFB
Study 30596749 — Surrogate Endpoint (SUR): Blood pressure
Study 27159952 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 17283363 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 17283363 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 17283363 — Predictive Biomarker (PRD): XIAP mRNA
Genes: XIAP; API3; BIRC4; IAP3
Study 16115131 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 28544533 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10705174 — Surrogate Endpoint (SUR): Blood pressure
Study 17609910 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 12002519 — Predictive Biomarker (PRD); Safety Biomarker (SAF): PSD mRNA
Genes: PSD; EFA6; EFA6A; KIAA2011; PSD1; TYL
Study 7882099 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 2239131 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 25644033 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 18832042 — Safety Biomarker (SAF): BCHE
Genes: E1
Study 415439 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 23855596 — Predictive Biomarker (PRD): KL mRNA
Genes: KL
Study 24846364 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 7492867 — Surrogate Endpoint (SUR): Bone mineral density
Study 24468996 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22583789 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 15750363 — Predictive Biomarker (PRD): SARS1 mRNA
Genes: SARS1; SARS; SERS
Study 1331444 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1331444 — Surrogate Endpoint (SUR): Blood pressure
Study 31401532 — Surrogate Endpoint (SUR): Blood pressure
Study 26735316 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 21368271 — Predictive Biomarker (PRD): FOXO1 mRNA
Genes: FOXO1; FKHR; FOXO1A
Study 21368271 — Predictive Biomarker (PRD): SREBF2 mRNA
Genes: SREBF2; BHLHD2; SREBP2
Study 21368271 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 21368271 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 21368271 — Predictive Biomarker (PRD); Safety Biomarker (SAF): SOD2 mRNA
Genes: SOD2
Study 12672170 — Predictive Biomarker (PRD): SI mRNA
Genes: SI
Study 10568767 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 3594319 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12351557 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25726845 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9558411 — Predictive Biomarker (PRD): CR1 mRNA
Genes: CR1; C3BR
Study 27828878 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9589700 — Surrogate Endpoint (SUR): Serum triglycerides
Study 30022377 — Surrogate Endpoint (SUR): Forced vital capacity
Study 11125766 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 31338989 — Predictive Biomarker (PRD): ALDH2 mRNA
Genes: ALDH2; ALDM
Study 31338989 — Surrogate Endpoint (SUR): Serum uric acid
Study 17460970 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31884852 — Surrogate Endpoint (SUR): Blood pressure
Study 19118820 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 1822804 — Predictive Biomarker (PRD): DMD mRNA
Genes: DMD
Study 30787162 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23381882 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 23381882 — Safety Biomarker (SAF): SLCO1B1
Genes: OATP-C; LST-1; OATP1B1
Study 19067190 — Predictive Biomarker (PRD): IGF1 mRNA
Genes: IGF1; IBP1
Study 19067190 — Predictive Biomarker (PRD): IGFBP3 mRNA
Genes: IGFBP3; IBP3
Study 31134822 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31134822 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18698212 — Predictive Biomarker (PRD): NANOS3 mRNA
Genes: NANOS3; NOS3
Study 18698212 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 18698212 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Angiotensinogen
Genes: AGT; SERPINA8
Study 18698212 — Predictive Biomarker (PRD): AGTR1 mRNA
Genes: AGTR1; AGTR1A; AGTR1B; AT2R1; AT2R1B
Study 16284192 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16284192 — Surrogate Endpoint (SUR): Serum triglycerides
Study 16284192 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16284192 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12851342 — Safety Biomarker (SAF): Hyaluronic acid
Study 1685992 — Surrogate Endpoint (SUR): Blood pressure
Study 8097925 — Surrogate Endpoint (SUR): Blood pressure
Study 3520318 — Surrogate Endpoint (SUR): Blood pressure
Study 15969244 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15969244 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10570746 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 8966142 — Surrogate Endpoint (SUR): Bone mineral density
Study 1526689 — Surrogate Endpoint (SUR): Blood pressure
Study 30412626 — Predictive Biomarker (PRD): MAS1 mRNA
Genes: MAS1; MAS
Study 11907712 — Surrogate Endpoint (SUR): Bone mineral density
Study 12552189 — Surrogate Endpoint (SUR): Blood pressure
Study 24220913 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24293132 — Surrogate Endpoint (SUR): Blood pressure
Study 24293132 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 20585834 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 20585834 — Predictive Biomarker (PRD): VKORC1 mRNA
Genes: VKORC1; VKOR; MSTP134; MSTP576; UNQ308/PRO351
Study 31625704 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31625704 — Predictive Biomarker (PRD): GLS mRNA
Genes: GLS; GLS1; KIAA0838
Study 21663857 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 15830733 — Surrogate Endpoint (SUR): Blood pressure
Study 2215707 — Surrogate Endpoint (SUR): Blood pressure
Study 31508533 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 31508533 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 31508533 — Surrogate Endpoint (SUR): Serum creatinine
Study 31508533 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 21526662 — Surrogate Endpoint (SUR): Blood pressure
Study 1760997 — Surrogate Endpoint (SUR): Blood pressure
Study 28832406 — Surrogate Endpoint (SUR): Bone mineral density
Study 21621629 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 18945998 — Surrogate Endpoint (SUR): Bone mineral density
Study 11079527 — Surrogate Endpoint (SUR): Bone mineral density
Study 9762660 — Predictive Biomarker (PRD): MBP mRNA
Genes: MBP
Study 9762660 — Predictive Biomarker (PRD): PDXP mRNA
Genes: PDXP; CIN; PLP; PLPP
Study 7918843 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 29686009 — Surrogate Endpoint (SUR): Blood pressure
Study 10464783 — Surrogate Endpoint (SUR): Blood pressure
Study 2142294 — Predictive Biomarker (PRD): PF4 mRNA
Genes: PF4; CXCL4; SCYB4
Study 2142294 — Predictive Biomarker (PRD): SERPINA7 mRNA
Genes: SERPINA7; TBG
Study 26900146 — Surrogate Endpoint (SUR): Bone mineral density
Study 7598580 — Safety Biomarker (SAF): Urinary total protein
Study 627129 — Surrogate Endpoint (SUR): Blood pressure
Study 31651183 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 29895406 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7786960 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 15140343 — Surrogate Endpoint (SUR): Bone mineral density
Study 11453887 — Safety Biomarker (SAF): ACE
Genes: ACE1; CD143
Study 29451145 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 22810757 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 7265455 — Surrogate Endpoint (SUR): Blood pressure
Study 23806847 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 23806847 — Predictive Biomarker (PRD): TSHR mRNA
Genes: TSHR; LGR3
Study 23806847 — Predictive Biomarker (PRD): DIO2 mRNA
Genes: DIO2; ITDI2; TXDI2
Study 23806847 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 23806847 — Predictive Biomarker (PRD): INSR mRNA
Genes: INSR
Study 19875410 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 31474354 — Predictive Biomarker (PRD): Homologous recombination deficiency
Study 19072600 — Predictive Biomarker (PRD): DAP mRNA
Genes: DAP; DAP1
Study 22243632 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 10205469 — Predictive Biomarker (PRD): NRP1 mRNA
Genes: NRP1; NRP; VEGF165R
Study 19335744 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 2464104 — Surrogate Endpoint (SUR): Blood pressure
Study 24964508 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 16052084 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22608570 — Surrogate Endpoint (SUR): Bone mineral density
Study 12637133 — Surrogate Endpoint (SUR): Serum creatinine
Study 10982163 — Surrogate Endpoint (SUR): Urinary oxalate
Study 9208534 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 9208534 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 1480877 — Surrogate Endpoint (SUR): Blood pressure
Study 22327404 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 20192907 — Surrogate Endpoint (SUR): Bone mineral density
Study 30721793 — Predictive Biomarker (PRD): CCND1
Genes: U21B31
Study 30721793 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 8050421 — Pharmacodynamic Biomarker (PDY): Cyclic adenosine monophosphate
Study 3184885 — Surrogate Endpoint (SUR): Blood pressure
Study 20807260 — Predictive Biomarker (PRD): LOXL1 mRNA
Genes: LOXL1; LOXL