TrialPanorama/TrialPanorama-database huggingface dataset:
Study 18724234 — Predictive Biomarker (PRD): SRL mRNA
Genes: SRL
Study 18724234 — Surrogate Endpoint (SUR): Blood pressure
Study 18724234 — Surrogate Endpoint (SUR): Serum creatinine
Study 23955431 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 19186342 — Surrogate Endpoint (SUR): Probing pocket depth
Study 11077934 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 11077934 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8839551 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 26702123 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26702123 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 17825128 — Surrogate Endpoint (SUR): Bone mineral density
Study 9952362 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 2407030 — Surrogate Endpoint (SUR): Blood pressure
Study 3436330 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 26126162 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 23228561 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 23228561 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 23228561 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor receptor 2
Genes: KDR; FLK1; VEGFR2
Study 15942543 — Surrogate Endpoint (SUR): Blood pressure
Study 7737260 — Predictive Biomarker (PRD): CCK mRNA
Genes: CCK
Study 23153560 — Predictive Biomarker (PRD): NR1I2
Genes: ONR1; PXR; BXR; SXR; PAR2
Study 23153560 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 19506391 — Surrogate Endpoint (SUR): Blood pressure
Study 16522903 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 16522903 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 16522903 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16522903 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16522903 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 8208641 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 8208641 — Surrogate Endpoint (SUR): Blood pressure
Study 27005755 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 10843152 — Surrogate Endpoint (SUR): Bone mineral density
Study 8983912 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 2205961 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 31399448 — Safety Biomarker (SAF): Reactive oxygen species
Study 23480028 — Safety Biomarker (SAF): SLCO1B1
Genes: OATP-C; LST-1; OATP1B1
Study 23480028 — Predictive Biomarker (PRD): SLCO1B1 mRNA
Genes: SLCO1B1; LST1; OATP1B1; OATP2; OATPC; SLC21A6
Study 19786678 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19786678 — Surrogate Endpoint (SUR): Serum potassium
Study 16510377 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16510377 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16510377 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 7709462 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 7709462 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 30056216 — Predictive Biomarker (PRD): LTA4H mRNA
Genes: LTA4H; LTA4
Study 30056216 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 25740742 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 25740742 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15845683 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 15845683 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 1753043 — Surrogate Endpoint (SUR): Bone mineral density
Study 14736964 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 14736964 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 14736964 — Surrogate Endpoint (SUR): Serum creatinine
Study 29628759 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19552060 — Surrogate Endpoint (SUR): Blood pressure
Study 11021272 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9472058 — Surrogate Endpoint (SUR): Blood pressure
Study 2468975 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 6987023 — Surrogate Endpoint (SUR): Blood pressure
Study 15848674 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 7891046 — Surrogate Endpoint (SUR): Blood pressure
Study 7891046 — Surrogate Endpoint (SUR): Serum triglycerides
Study 7891046 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9014628 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 2951818 — Surrogate Endpoint (SUR): Forced vital capacity
Study 29474803 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29474803 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 25002101 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 22575316 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 22575316 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21094364 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 18503515 — Safety Biomarker (SAF): Interleukin 1
Study 18503515 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 18503515 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18503515 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 15902961 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 1799900 — Surrogate Endpoint (SUR): Blood pressure
Study 31926856 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31039172 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26729193 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22585352 — Surrogate Endpoint (SUR): Bone mineral density
Study 12133139 — Predictive Biomarker (PRD): PRCP mRNA
Genes: PRCP; PCP
Study 9486936 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9486936 — Surrogate Endpoint (SUR): Blood pressure
Study 9486936 — Surrogate Endpoint (SUR): Serum potassium
Study 7965272 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7965272 — Surrogate Endpoint (SUR): Blood pressure
Study 3315173 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 19660338 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 2411649 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26721935 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20594588 — Surrogate Endpoint (SUR): Serum creatinine
Study 16269081 — Surrogate Endpoint (SUR): Blood pressure
Study 10080828 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 2344503 — Surrogate Endpoint (SUR): Blood pressure
Study 30475668 — Predictive Biomarker (PRD): Hormone receptor
Study 25238025 — Predictive Biomarker (PRD): SLC5A2 mRNA
Genes: SLC5A2; SGLT2
Study 18436088 — Surrogate Endpoint (SUR): Serum creatinine
Study 18436088 — Surrogate Endpoint (SUR): Blood pressure
Study 18436088 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23222818 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 23222818 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 17157730 — Predictive Biomarker (PRD): MYRF mRNA
Genes: MYRF; C11orf9; KIAA0954; MRF
Study 11025241 — Surrogate Endpoint (SUR): Blood pressure
Study 6398125 — Predictive Biomarker (PRD): CFL1 mRNA
Genes: CFL1; CFL
Study 30084900 — Safety Biomarker (SAF): Hyaluronic acid
Study 22684197 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 11214766 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 11214766 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 19950043 — Predictive Biomarker (PRD): CNP mRNA
Genes: CNP
Study 19950043 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 19950043 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 16246772 — Surrogate Endpoint (SUR): Blood pressure
Study 11873008 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31988253 — Predictive Biomarker (PRD): CENPJ mRNA
Genes: CENPJ; CPAP; LAP; LIP1
Study 28183331 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 28183331 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 28183331 — Predictive Biomarker (PRD): FGFR1 mRNA
Genes: FGFR1; BFGFR; CEK; FGFBR; FLG; FLT2; HBGFR
Study 28183331 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor receptor
Study 28183331 — Predictive Biomarker (PRD): Hormone receptor
Study 25631454 — Predictive Biomarker (PRD): MCCC2 mRNA
Genes: MCCC2; MCCB
Study 21827664 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 21827664 — Surrogate Endpoint (SUR): Blood pressure
Study 19906505 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 19906505 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19906505 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 10737366 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 29150850 — Predictive Biomarker (PRD): LTA mRNA
Genes: LTA; TNFB; TNFSF1
Study 29150850 — Predictive Biomarker (PRD): VASP mRNA
Genes: VASP
Study 27362350 — Surrogate Endpoint (SUR): Blood pressure
Study 21965226 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24719128 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24719128 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 17919894 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 3926614 — Surrogate Endpoint (SUR): Blood pressure
Study 29636305 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 29636305 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 27821107 — Predictive Biomarker (PRD): PCSK5 mRNA
Genes: PCSK5; PC5; PC6
Study 25070320 — Predictive Biomarker (PRD): CYP2R1 mRNA
Genes: CYP2R1
Study 25070320 — Predictive Biomarker (PRD): CYP24A1 mRNA
Genes: CYP24A1; CYP24
Study 25070320 — Predictive Biomarker (PRD): VDR mRNA
Genes: VDR; NR1I1
Study 25070320 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 25070320 — Predictive Biomarker (PRD): DHCR7 mRNA
Genes: DHCR7; D7SR
Study 25070320 — Predictive Biomarker (PRD): CYP27B1 mRNA
Genes: CYP27B1; CYP1ALPHA; CYP27B
Study 25070320 — Predictive Biomarker (PRD): CASR mRNA
Genes: CASR; GPRC2A; PCAR1
Study 22480187 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 26740259 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 26740259 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 22402803 — Surrogate Endpoint (SUR): Serum creatinine
Study 20384499 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 18480682 — Predictive Biomarker (PRD): PGD mRNA
Genes: PGD; PGDH
Study 16316784 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 31299999 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 28301614 — Predictive Biomarker (PRD): WWTR1 mRNA
Genes: WWTR1; TAZ
Study 10664926 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 10664926 — Surrogate Endpoint (SUR): Blood pressure
Study 27181179 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27181179 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 27181179 — Safety Biomarker (SAF): Interleukin 18
Genes: IL18; IGIF; IL1F4
Study 27181179 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22538137 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18286187 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 29542045 — Predictive Biomarker (PRD): KCNH2 mRNA
Genes: KCNH2; ERG; ERG1; HERG
Study 19779715 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 16244021 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 16244021 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 16244021 — Surrogate Endpoint (SUR): Blood pressure
Study 11857606 — Surrogate Endpoint (SUR): Probing pocket depth
Study 26012258 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20376075 — Surrogate Endpoint (SUR): Blood pressure
Study 14651726 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 29099344 — Predictive Biomarker (PRD): CFTR mRNA
Genes: CFTR; ABCC7
Study 22811471 — Predictive Biomarker (PRD): Hormone receptor
Study 29501977 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 29501977 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 29501977 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 10321112 — Surrogate Endpoint (SUR): Blood pressure
Study 10321112 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16505497 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 16505497 — Surrogate Endpoint (SUR): Blood pressure
Study 8320055 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 21181560 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 320112 — Surrogate Endpoint (SUR): Blood pressure
Study 320112 — Surrogate Endpoint (SUR): Serum potassium
Study 28486907 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8070301 — Predictive Biomarker (PRD): MPG mRNA
Genes: MPG; AAG; ANPG; MID1
Study 30210790 — Predictive Biomarker (PRD): KCNIP3 mRNA
Genes: KCNIP3; CSEN; DREAM; KCHIP3
Study 20819623 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17162329 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17162329 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12802709 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 10987850 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Mitochondrial DNA
Study 12204499 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25350782 — Surrogate Endpoint (SUR): Blood pressure
Study 20538300 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15566933 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 18394451 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 8623968 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 25846070 — Safety Biomarker (SAF): Eosinophil cationic protein
Genes: RNASE3; ECP; RNS3
Study 25846070 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 18284641 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 18284641 — Surrogate Endpoint (SUR): Blood pressure
Study 31693275 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 31693275 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 15473615 — Surrogate Endpoint (SUR): Blood pressure
Study 11479476 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 11479476 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9496728 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 2457305 — Surrogate Endpoint (SUR): Blood pressure
Study 16304673 — Surrogate Endpoint (SUR): Serum sodium
Study 11548229 — Predictive Biomarker (PRD): CS mRNA
Genes: CS
Study 11548229 — Safety Biomarker (SAF): Hyaluronic acid
Study 24867408 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 24867408 — Predictive Biomarker (PRD): S100A8 mRNA
Genes: S100A8; CAGA; CFAG; MRP8
Study 20138189 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 26818420 — Predictive Biomarker (PRD): S100A12 mRNA
Genes: S100A12
Study 26818420 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20195613 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 7747698 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 27658762 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 28183863 — Surrogate Endpoint (SUR): Blood pressure
Study 19372341 — Surrogate Endpoint (SUR): Blood pressure
Study 15340345 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 15340345 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15340345 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15340345 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 29899047 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 21742096 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21742096 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19854539 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MUC5AC mRNA
Genes: MUC5AC; MUC5
Study 8198022 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8198022 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 31719072 — Surrogate Endpoint (SUR): Forced vital capacity
Study 12598435 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 26614481 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23130817 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 18325887 — Surrogate Endpoint (SUR): Blood pressure
Study 15569851 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15569851 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 28975718 — Surrogate Endpoint (SUR): Serum uric acid
Study 9525445 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 860200 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 30880441 — Surrogate Endpoint (SUR): Blood pressure
Study 30880441 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 25992918 — Surrogate Endpoint (SUR): Serum creatinine
Study 25992918 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25992918 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25992918 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 10090549 — Surrogate Endpoint (SUR): Blood pressure
Study 119526 — Predictive Biomarker (PRD): PTN mRNA
Genes: PTN; HBNF1; NEGF1
Study 19922961 — Surrogate Endpoint (SUR): Blood pressure
Study 19922961 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31833175 — Predictive Biomarker (PRD): PTPRC mRNA
Genes: PTPRC; CD45
Study 17944686 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15356029 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 15356029 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16473558 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 1468386 — Surrogate Endpoint (SUR): Blood pressure
Study 30976851 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 20417447 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17021587 — Pharmacodynamic Biomarker (PDY): Heat pain threshold
Study 11966932 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 30825407 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 29288035 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 23584298 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 23584298 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 23584298 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2