TrialPanorama/TrialPanorama-database huggingface dataset:
Study 17710290 — Surrogate Endpoint (SUR): Probing pocket depth
Study 18216764 — Surrogate Endpoint (SUR): Blood pressure
Study 16521223 — Surrogate Endpoint (SUR): Blood pressure
Study 11101061 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11101061 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 29373334 — Surrogate Endpoint (SUR): Blood pressure
Study 31118095 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 31118095 — Predictive Biomarker (PRD): COMT mRNA
Genes: COMT
Study 31118095 — Safety Biomarker (SAF): BDNF
Study 10720591 — Surrogate Endpoint (SUR): Blood pressure
Study 26109202 — Predictive Biomarker (PRD): TRIL mRNA
Genes: TRIL; KIAA0644
Study 19502017 — Surrogate Endpoint (SUR): Blood pressure
Study 18284462 — Surrogate Endpoint (SUR): Blood pressure
Study 18284462 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15918446 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 15918446 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 15918446 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12095495 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 12095495 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 7985893 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 2974416 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 18317189 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 20938039 — Monitoring Biomarker (MOI): Heme oxygenase 1
Genes: HMOX1; HO; HO1
Study 7607751 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7607751 — Surrogate Endpoint (SUR): Blood pressure
Study 7607751 — Surrogate Endpoint (SUR): Serum creatinine
Study 20523301 — Predictive Biomarker (PRD): ADRB2 mRNA
Genes: ADRB2; ADRB2R; B2AR
Study 31165854 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 31165854 — Predictive Biomarker (PRD): Hormone receptor
Study 12119210 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 9710040 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 7480965 — Surrogate Endpoint (SUR): Blood pressure
Study 7480965 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 2470569 — Surrogate Endpoint (SUR): Blood pressure
Study 25111121 — Surrogate Endpoint (SUR): Blood pressure
Study 22981146 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 9625823 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 23986090 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 20659263 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 6319633 — Surrogate Endpoint (SUR): Blood pressure
Study 28944645 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 31131743 — Predictive Biomarker (PRD): FMOD mRNA
Genes: FMOD; FM; SLRR2E
Study 19741042 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 1723773 — Surrogate Endpoint (SUR): Blood pressure
Study 27737436 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 1337337 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 15634808 — Surrogate Endpoint (SUR): Bone mineral density
Study 24495355 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 9834924 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 9834924 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30590973 — Predictive Biomarker (PRD): S100B mRNA
Genes: S100B
Study 15670536 — Surrogate Endpoint (SUR): Blood pressure
Study 7589641 — Surrogate Endpoint (SUR): Blood pressure
Study 7589641 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7589641 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 17724493 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 10049414 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 10049414 — Surrogate Endpoint (SUR): Serum alkaline phosphatase and bilirubin
Study 14678954 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 11434175 — Surrogate Endpoint (SUR): Blood pressure
Study 9070128 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 8508727 — Surrogate Endpoint (SUR): Blood pressure
Study 11027812 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 6488684 — Surrogate Endpoint (SUR): Blood pressure
Study 30570525 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 1898743 — Predictive Biomarker (PRD): GNRH1 mRNA
Genes: GNRH1; GNRH; GRH; LHRH
Study 16253595 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 12384411 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 23128822 — Surrogate Endpoint (SUR): Blood pressure
Study 19104723 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16144890 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 6352272 — Surrogate Endpoint (SUR): Blood pressure
Study 24830937 — Surrogate Endpoint (SUR): Blood pressure
Study 29493562 — Surrogate Endpoint (SUR): Blood pressure
Study 7623907 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7128668 — Surrogate Endpoint (SUR): Blood pressure
Study 20609467 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 20609467 — Predictive Biomarker (PRD): BRCA2 mRNA
Genes: BRCA2; FACD; FANCD1
Study 902232 — Predictive Biomarker (PRD): MERTK mRNA
Genes: MERTK; MER
Study 15380456 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 15380456 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 10734016 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 3926511 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 30700364 — Safety Biomarker (SAF): Biliary glycoprotein 1
Genes: CEACAM1; BGP; BGP1
Study 11361052 — Surrogate Endpoint (SUR): Blood pressure
Study 31533069 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 31533069 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18772216 — Surrogate Endpoint (SUR): Blood pressure
Study 8675164 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8675164 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 8675164 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 8675164 — Safety Biomarker (SAF): Interleukin 1
Study 1676306 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 26677770 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 2138049 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 106432 — Surrogate Endpoint (SUR): Blood pressure
Study 27255243 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 25238912 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 11774098 — Surrogate Endpoint (SUR): Serum creatinine
Study 10610077 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 10610077 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 619949 — Predictive Biomarker (PRD): EMB mRNA
Genes: EMB
Study 1599353 — Surrogate Endpoint (SUR): Blood pressure
Study 24096258 — Surrogate Endpoint (SUR): Blood pressure
Study 28060545 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11920457 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 9280994 — Surrogate Endpoint (SUR): Blood pressure
Study 1587065 — Surrogate Endpoint (SUR): Blood pressure
Study 27328023 — Predictive Biomarker (PRD): HPR mRNA
Genes: HPR
Study 25537204 — Predictive Biomarker (PRD): RPE65 mRNA
Genes: RPE65
Study 22546535 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19566584 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15809508 — Pharmacodynamic Biomarker (PDY): Serum phosphate
Study 15809508 — Surrogate Endpoint (SUR): Serum phosphate
Study 11808976 — Monitoring Biomarker (MOI): Tissue transglutaminase
Genes: TGM2
Study 6999618 — Predictive Biomarker (PRD): NXF1 mRNA
Genes: NXF1; TAP
Study 21394639 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 11589932 — Surrogate Endpoint (SUR): Blood pressure
Study 11589932 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9751239 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7942122 — Safety Biomarker (SAF): Reactive oxygen species
Study 23302902 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 12600846 — Predictive Biomarker (PRD): LPL mRNA
Genes: LPL; LIPD
Study 10962425 — Surrogate Endpoint (SUR): Blood pressure
Study 27166360 — Predictive Biomarker (PRD): MEF2B mRNA
Genes: MEF2B; XMEF2
Study 27166360 — Monitoring Biomarker (MOI): Circulating tumor DNA
Study 8619521 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26891418 — Predictive Biomarker (PRD): IFNL3 mRNA
Genes: IFNL3; IL28B; IL28C; ZCYTO22
Study 19174497 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 9587048 — Predictive Biomarker (PRD): EPHA3 mRNA
Genes: EPHA3; ETK; ETK1; HEK; TYRO4
Study 8017465 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25636814 — Surrogate Endpoint (SUR): Blood pressure
Study 11387994 — Predictive Biomarker (PRD): OAT mRNA
Genes: OAT
Study 21438929 — Predictive Biomarker (PRD): NPY mRNA
Genes: NPY
Study 20335115 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11380317 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 2851179 — Surrogate Endpoint (SUR): Serum creatinine
Study 23123199 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 23123199 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 23123199 — Safety Biomarker (SAF): BDNF
Study 23123199 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 25452309 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24506950 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 24958250 — Surrogate Endpoint (SUR): Blood pressure
Study 20539854 — Surrogate Endpoint (SUR): Blood pressure
Study 15732857 — Surrogate Endpoint (SUR): Bone mineral density
Study 30638840 — Surrogate Endpoint (SUR): Blood pressure
Study 22136024 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 30548118 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 30548118 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30548118 — Surrogate Endpoint (SUR): Blood pressure
Study 29798118 — Predictive Biomarker (PRD): SDS mRNA
Genes: SDS; SDH
Study 16809572 — Predictive Biomarker (PRD): TNF-related weak inducer of apoptosis
Genes: TNFSF12; APO3L; DR3LG; UNQ181/PRO207
Study 16809572 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16809572 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 2887542 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 2887542 — Surrogate Endpoint (SUR): Blood pressure
Study 18471252 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 16509867 — Predictive Biomarker (PRD): EVL mRNA
Genes: EVL; RNB6
Study 9172131 — Predictive Biomarker (PRD): CCDC88A mRNA
Genes: CCDC88A; APE; GRDN; KIAA1212
Study 9172131 — Safety Biomarker (SAF): Reactive oxygen species
Study 22562609 — Predictive Biomarker (PRD): CBR1 mRNA
Genes: CBR1; CBR; CRN; SDR21C1
Study 22562609 — Predictive Biomarker (PRD): CBR3 mRNA
Genes: CBR3; SDR21C2
Study 2756353 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31359814 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31138020 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 11220085 — Surrogate Endpoint (SUR): Blood pressure
Study 29194749 — Surrogate Endpoint (SUR): Bone mineral density
Study 23337343 — Predictive Biomarker (PRD): CNR1 mRNA
Genes: CNR1; CNR
Study 23337343 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16773618 — Predictive Biomarker (PRD): LPP mRNA
Genes: LPP
Study 8882695 — Surrogate Endpoint (SUR): Serum sodium
Study 23155019 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 31272326 — Surrogate Endpoint (SUR): Blood pressure
Study 28029656 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 28029656 — Safety Biomarker (SAF): Neutrophil to lymphocyte
Study 28029656 — Safety Biomarker (SAF): Platelet to lymphocyte
Study 25631875 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 22523532 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 9923412 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 8072258 — Surrogate Endpoint (SUR): Serum creatinine
Study 31194213 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 21576655 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19260129 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 17101806 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 15456520 — Surrogate Endpoint (SUR): Serum creatinine
Study 8773158 — Surrogate Endpoint (SUR): Blood pressure
Study 1281103 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 14640990 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17425871 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 12627416 — Predictive Biomarker (PRD): USH1G mRNA
Genes: USH1G; SANS
Study 17982923 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 12032413 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 12032413 — Predictive Biomarker (PRD): IK mRNA
Genes: IK; RED; RER
Study 9241008 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 10369627 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 24622577 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24622577 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 27110446 — Predictive Biomarker (PRD): OXTR mRNA
Genes: OXTR
Study 14652120 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 14652120 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 10646124 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 10646124 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30815880 — Monitoring Biomarker (MOI): HBV DNA
Study 26681403 — Predictive Biomarker (PRD): GCLC mRNA
Genes: GCLC; GLCL; GLCLC
Study 26681403 — Monitoring Biomarker (MOI): Heme oxygenase 1
Genes: HMOX1; HO; HO1
Study 26681403 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 26681403 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 26681403 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 22968523 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18802155 — Surrogate Endpoint (SUR): Bone mineral density
Study 8450893 — Predictive Biomarker (PRD): AOX1 mRNA
Genes: AOX1; AO
Study 8450893 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 26271141 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17475459 — Surrogate Endpoint (SUR): Blood pressure
Study 29858919 — Surrogate Endpoint (SUR): Blood pressure
Study 25297012 — Predictive Biomarker (PRD): SLC1A2 mRNA
Genes: SLC1A2; EAAT2; GLT1
Study 10424315 — Surrogate Endpoint (SUR): Blood pressure
Study 29747269 — Surrogate Endpoint (SUR): Bone mineral density
Study 31506369 — Surrogate Endpoint (SUR): Blood pressure
Study 27776149 — Surrogate Endpoint (SUR): Blood pressure
Study 24964509 — Safety Biomarker (SAF): Reactive oxygen species
Study 14557560 — Predictive Biomarker (PRD): VIM mRNA
Genes: VIM
Study 17519820 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAV1 mRNA
Genes: CAV1; CAV
Study 15369510 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7986469 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26205747 — Surrogate Endpoint (SUR): Blood pressure
Study 26205747 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26205747 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 26205747 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 26205747 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21672969 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29281604 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 29281604 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17253883 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 17253883 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 15817726 — Surrogate Endpoint (SUR): Blood pressure
Study 23462833 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23462833 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23462833 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 21276586 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21276586 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21276586 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 21276586 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 21276586 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 24084625 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 8222677 — Surrogate Endpoint (SUR): Blood pressure
Study 8222677 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 30127051 — Surrogate Endpoint (SUR): Blood pressure
Study 18420877 — Surrogate Endpoint (SUR): Blood pressure
Study 17035872 — Surrogate Endpoint (SUR): Serum creatinine
Study 28982501 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23426978 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 11717214 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 26769742 — Surrogate Endpoint (SUR): Blood pressure
Study 30804065 — Surrogate Endpoint (SUR): Serum calcium
Study 18591543 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 15842212 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7640501 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 18400704 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 14512000 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14512000 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 14512000 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 31101682 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 31101682 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31101682 — Surrogate Endpoint (SUR): Blood pressure
Study 7850234 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 28287490 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Monitoring Biomarker (MOI): Vitamin B12
Study 14633536 — Safety Biomarker (SAF): DRD2
Study 24710254 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24710254 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23474349 — Predictive Biomarker (PRD): HBB mRNA
Genes: HBB
Study 10337871 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 10337871 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21816640 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 21640687 — Surrogate Endpoint (SUR): Blood pressure
Study 30053670 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 22137609 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 22137609 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 31782009 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31782009 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 19814835 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19814835 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19814835 — Safety Biomarker (SAF): Human leucocyte antigen
Study 20329616 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 7707626 — Surrogate Endpoint (SUR): Neutralizing antibody