TrialPanorama/TrialPanorama-database huggingface dataset:
Study 21128879 — Surrogate Endpoint (SUR): Blood pressure
Study 16983056 — Pharmacodynamic Biomarker (PDY): Cyclic guanosine monophosphate
Study 11044422 — Surrogate Endpoint (SUR): Blood pressure
Study 29713889 — Predictive Biomarker (PRD); Safety Biomarker (SAF): FGG mRNA
Genes: FGG; PRO2061
Study 10931808 — Predictive Biomarker (PRD): TF mRNA
Genes: TF; PRO1400
Study 10931808 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 31732851 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31732851 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 21668768 — Surrogate Endpoint (SUR): Blood pressure
Study 14699021 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14699021 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19001202 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 19001202 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 19001202 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19001202 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 19001202 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 19001202 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 2985395 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30207079 — Surrogate Endpoint (SUR): Blood pressure
Study 26663540 — Surrogate Endpoint (SUR): Serum testosterone
Study 25126867 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25126867 — Surrogate Endpoint (SUR): Blood pressure
Study 18360659 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 16737046 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 16737046 — Monitoring Biomarker (MOI): IL4 mRNA
Genes: IL4
Study 16737046 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 10
Genes: IL10
Study 10688158 — Safety Biomarker (SAF): DRD2
Study 24119856 — Predictive Biomarker (PRD): MCIDAS mRNA
Genes: MCIDAS; IDAS; MCI; MCIN
Study 21917299 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 21917299 — Surrogate Endpoint (SUR): Blood pressure
Study 21917299 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 17157442 — Surrogate Endpoint (SUR): Blood pressure
Study 7549418 — Predictive Biomarker (PRD): VIP mRNA
Genes: VIP
Study 31344386 — Predictive Biomarker (PRD): AHR mRNA
Genes: AHR; BHLHE76
Study 27150460 — Safety Biomarker (SAF): Lactotransferrin
Genes: LTF; GIG12; LF
Study 27150460 — Predictive Biomarker (PRD): LPO mRNA
Genes: LPO; SAPX
Study 21511526 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 15231010 — Surrogate Endpoint (SUR): New morphometric vertebral fractures
Study 31578273 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Tumor mutational burden
Study 31578273 — Predictive Biomarker (PRD): Microsatellite instability
Study 27027204 — Predictive Biomarker (PRD): NLRP1 mRNA
Genes: NLRP1; CARD7; DEFCAP; KIAA0926; NAC; NALP1
Study 19952780 — Surrogate Endpoint (SUR): Blood pressure
Study 19069453 — Pharmacodynamic Biomarker (PDY): Blood coagulation
Study 19069453 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 16809906 — Surrogate Endpoint (SUR): Serum triglycerides
Study 29369166 — Predictive Biomarker (PRD): TFPI mRNA
Genes: TFPI; LACI; TFPI1
Study 29369166 — Predictive Biomarker (PRD): CCL24 mRNA
Genes: CCL24; MPIF2; SCYA24
Study 29369166 — Predictive Biomarker (PRD): MBL2 mRNA
Genes: MBL2; COLEC1; MBL
Study 29369166 — Predictive Biomarker (PRD): PCOLCE mRNA
Genes: PCOLCE; PCPE1
Study 28698390 — Predictive Biomarker (PRD): Hormone receptor
Study 21535040 — Surrogate Endpoint (SUR): Blood pressure
Study 16547619 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 16547619 — Surrogate Endpoint (SUR): Serum calcium
Study 27936169 — Predictive Biomarker (PRD): FOS mRNA
Genes: FOS; G0S7
Study 19225400 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11279411 — Surrogate Endpoint (SUR): Forced vital capacity
Study 8989263 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 20497745 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 20497745 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 10835452 — Monitoring Biomarker (MOI): Carcinoembryonic antigen CEA
Genes: CEACAM5; CEA
Study 3736281 — Surrogate Endpoint (SUR): Blood pressure
Study 24088749 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 24088749 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 19624691 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 15266766 — Surrogate Endpoint (SUR): Bone mineral density
Study 11497198 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 11497198 — Surrogate Endpoint (SUR): Blood pressure
Study 9513582 — Surrogate Endpoint (SUR): Forced vital capacity
Study 18266878 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18266878 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8469319 — Predictive Biomarker (PRD): UBC mRNA
Genes: UBC
Study 9588606 — Predictive Biomarker (PRD): CFP mRNA
Genes: CFP; PFC
Study 30646129 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 10372711 — Surrogate Endpoint (SUR): Blood pressure
Study 2051004 — Monitoring Biomarker (MOI): HBV DNA
Study 29582053 — Predictive Biomarker (PRD): Nerve growth factor
Genes: NGF; NGFB
Study 24913837 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 16264047 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 21917518 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 21917518 — Predictive Biomarker (PRD): TOP2A mRNA
Genes: TOP2A; TOP2
Study 18937013 — Surrogate Endpoint (SUR): Blood pressure
Study 16913498 — Predictive Biomarker (PRD): DST mRNA
Genes: DST; BP230; BP240; BPAG1; DMH; DT; KIAA0728
Study 14709940 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 11137416 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 8265878 — Surrogate Endpoint (SUR): Forced vital capacity
Study 3011023 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3011023 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 30537261 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 21455612 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 21455612 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23913601 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 8713772 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): D-dimer
Study 1439288 — Surrogate Endpoint (SUR): Blood pressure
Study 2986932 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 30371169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30371169 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 27423256 — Predictive Biomarker (PRD): PDE10A mRNA
Genes: PDE10A
Study 25483462 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 19629583 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 22174039 — Monitoring Biomarker (MOI): HBV DNA
Study 18416221 — Monitoring Biomarker (MOI): Procalcitonin
Study 18416221 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15884752 — Surrogate Endpoint (SUR): Serum sodium
Study 12074773 — Predictive Biomarker (PRD): FES mRNA
Genes: FES; FPS
Study 1937659 — Surrogate Endpoint (SUR): Blood pressure
Study 15293079 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15293079 — Surrogate Endpoint (SUR): Serum triglycerides
Study 25935422 — Surrogate Endpoint (SUR): Blood pressure
Study 22149470 — Surrogate Endpoint (SUR): Blood pressure
Study 11126465 — Surrogate Endpoint (SUR): Blood pressure
Study 21224436 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 16508584 — Surrogate Endpoint (SUR): Blood pressure
Study 18550933 — Surrogate Endpoint (SUR): Blood pressure
Study 15820793 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 8881840 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 8881840 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8510082 — Surrogate Endpoint (SUR): Blood pressure
Study 2961938 — Surrogate Endpoint (SUR): Serum testosterone
Study 31637452 — Surrogate Endpoint (SUR): Blood pressure
Study 23628696 — Predictive Biomarker (PRD): SST mRNA
Genes: SST
Study 19793768 — Predictive Biomarker (PRD): PPARA mRNA
Genes: PPARA; NR1C1; PPAR
Study 19793768 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19793768 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 16670135 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10381288 — Predictive Biomarker (PRD): TAT mRNA
Genes: TAT
Study 10381288 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 29749323 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8551733 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Adrenomedullin
Genes: ADM; AM
Study 8551733 — Predictive Biomarker (PRD): CPA1 mRNA
Genes: CPA1; CPA
Study 389419 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 389419 — Predictive Biomarker (PRD): SELENBP1 mRNA
Genes: SELENBP1; SBP
Study 389419 — Surrogate Endpoint (SUR): Blood pressure
Study 389419 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 31434498 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24969577 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 22099425 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 30004255 — Surrogate Endpoint (SUR): Bone mineral density
Study 10334388 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31502323 — Surrogate Endpoint (SUR): Blood pressure
Study 26455521 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22143452 — Surrogate Endpoint (SUR): Blood pressure
Study 19317824 — Surrogate Endpoint (SUR): Blood pressure
Study 11163559 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 28486329 — Predictive Biomarker (PRD); Safety Biomarker (SAF): CAT mRNA
Genes: CAT
Study 28486329 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 19695194 — Safety Biomarker (SAF): Beta-2-microglobulin
Genes: B2M; CDABP0092; HDCMA22P
Study 11566623 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 11566623 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 11566623 — Predictive Biomarker (PRD): Proliferation marker protein Ki-67
Genes: MKI67
Study 9785067 — Surrogate Endpoint (SUR): Blood pressure
Study 30672234 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30672234 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30672234 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30672234 — Predictive Biomarker (PRD): IL6
Genes: IL-6; BSF2; HGF; HSF
Study 30672234 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 24085784 — Predictive Biomarker (PRD): CD5 mRNA
Genes: CD5; LEU1
Study 24085784 — Predictive Biomarker (PRD): CD27 mRNA
Genes: CD27; TNFRSF7
Study 24085784 — Predictive Biomarker (PRD): CD69 mRNA
Genes: CD69; CLEC2C
Study 24085784 — Predictive Biomarker (PRD): CD24 mRNA
Genes: CD24; CD24A
Study 24085784 — Monitoring Biomarker (MOI): HBV DNA
Study 18242338 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 16845251 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 16845251 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 1626037 — Surrogate Endpoint (SUR): Blood pressure
Study 30182359 — Predictive Biomarker (PRD): TPO mRNA
Genes: TPO
Study 30182359 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 20080842 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 8140926 — Surrogate Endpoint (SUR): Bone mineral density
Study 386062 — Surrogate Endpoint (SUR): Blood pressure
Study 25296344 — Predictive Biomarker (PRD): FOXO1 mRNA
Genes: FOXO1; FKHR; FOXO1A
Study 24912899 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 9521232 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 2533973 — Surrogate Endpoint (SUR): Serum creatinine
Study 2533973 — Surrogate Endpoint (SUR): Blood pressure
Study 23589562 — Surrogate Endpoint (SUR): Blood pressure
Study 23589562 — Surrogate Endpoint (SUR): Serum creatinine
Study 15181130 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8841148 — Surrogate Endpoint (SUR): Blood pressure
Study 19368768 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 16448520 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16448520 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 16448520 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 12633795 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10835443 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 20664534 — Predictive Biomarker (PRD): SLCO2B1 mRNA
Genes: SLCO2B1; KIAA0880; OATP2B1; OATPB; SLC21A9
Study 20664534 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 26021958 — Surrogate Endpoint (SUR): Blood pressure
Study 17619851 — Surrogate Endpoint (SUR): Serum sodium
Study 30351388 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30351388 — Surrogate Endpoint (SUR): Blood pressure
Study 10381291 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8963837 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 1 beta
Genes: IL1B; IL1F2
Study 8963837 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 18492754 — Surrogate Endpoint (SUR): Serum calcium
Study 8729614 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 27017207 — Predictive Biomarker (PRD): Hormone receptor
Study 24375969 — Surrogate Endpoint (SUR): Blood pressure
Study 17341532 — Surrogate Endpoint (SUR): Blood pressure
Study 3098484 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30518682 — Pharmacodynamic Biomarker (PDY): Fibroblast growth factor 23
Genes: FGF23; HYPF; UNQ3027/PRO9828
Study 22745245 — Pharmacodynamic Biomarker (PDY): Dipeptidyl peptidase 4
Genes: DPP4; ADCP2; CD26
Study 22745245 — Safety Biomarker (SAF): c-Jun N-terminal kinase
Study 22745245 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 22745245 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 8644689 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 3552458 — Surrogate Endpoint (SUR): Blood pressure
Study 7515649 — Predictive Biomarker (PRD): DDIT3 mRNA
Genes: DDIT3; CHOP; CHOP10; GADD153
Study 7515649 — Predictive Biomarker (PRD): RTEL1 mRNA
Genes: RTEL1; C20orf41; KIAA1088; NHL
Study 2454376 — Surrogate Endpoint (SUR): Blood pressure
Study 25131773 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 25131773 — Surrogate Endpoint (SUR): Bone mineral density
Study 25131773 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 25131773 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 22572633 — Safety Biomarker (SAF): Reactive oxygen species
Study 22572633 — Surrogate Endpoint (SUR): Serum creatinine
Study 25763201 — Surrogate Endpoint (SUR): Blood pressure
Study 20678674 — Surrogate Endpoint (SUR): Blood pressure
Study 8258959 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 8258959 — Surrogate Endpoint (SUR): Serum creatinine
Study 8258959 — Surrogate Endpoint (SUR): Serum triglycerides
Study 4042390 — Surrogate Endpoint (SUR): Blood pressure
Study 25225285 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25225285 — Surrogate Endpoint (SUR): Blood pressure
Study 15014210 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 8077888 — Surrogate Endpoint (SUR): Blood pressure
Study 2589002 — Surrogate Endpoint (SUR): Blood pressure
Study 29162132 — Surrogate Endpoint (SUR): Blood pressure
Study 31899035 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31899035 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 31899035 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 31899035 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 22000810 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 22000810 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 31099387 — Surrogate Endpoint (SUR): Blood pressure
Study 9737514 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 25262178 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 25262178 — Pharmacodynamic Biomarker (PDY): Valproic acid
Study 25262178 — Safety Biomarker (SAF): BDNF
Study 18069576 — Surrogate Endpoint (SUR): Blood pressure
Study 366141 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 25052361 — Surrogate Endpoint (SUR): Blood pressure
Study 22399699 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16316360 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16316360 — Surrogate Endpoint (SUR): Blood pressure
Study 10826395 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 10826395 — Surrogate Endpoint (SUR): Blood pressure
Study 8651166 — Surrogate Endpoint (SUR): Serum calcium
Study 29762253 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 31505228 — Predictive Biomarker (PRD): MSC mRNA
Genes: MSC; ABF1; BHLHA22
Study 28091858 — Surrogate Endpoint (SUR): Blood pressure
Study 21471414 — Surrogate Endpoint (SUR): Bone mineral density
Study 19123930 — Surrogate Endpoint (SUR): Serum triglycerides
Study 17317762 — Safety Biomarker (SAF): Peroxisome proliferator-activated receptor alpha
Genes: PPARA
Study 15750983 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8187255 — Surrogate Endpoint (SUR): Blood pressure
Study 25650049 — Predictive Biomarker (PRD): HTR2C mRNA
Genes: HTR2C; HTR1C
Study 19208649 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 19208649 — Predictive Biomarker (PRD): CXCR4 mRNA
Genes: CXCR4
Study 10853626 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9104515 — Predictive Biomarker (PRD): EDA mRNA
Genes: EDA; ED1; EDA2
Study 9104515 — Surrogate Endpoint (SUR): Blood pressure
Study 3572208 — Surrogate Endpoint (SUR): Blood pressure
Study 21778247 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 19433800 — Safety Biomarker (SAF): Reactive oxygen species
Study 11371683 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 28041817 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 28041817 — Surrogate Endpoint (SUR): Blood pressure
Study 24244325 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20833235 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 20833235 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 18496373 — Predictive Biomarker (PRD): REM1 mRNA
Genes: REM1; GES; REM
Study 25503770 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 9928753 — Surrogate Endpoint (SUR): Blood pressure
Study 7495045 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 23218813 — Predictive Biomarker (PRD): SPN mRNA
Genes: SPN; CD43
Study 30400570 — Surrogate Endpoint (SUR): Blood pressure
Study 30400570 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 30400570 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30400570 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 20858857 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 10355866 — Surrogate Endpoint (SUR): Serum triglycerides
Study 29782224 — Safety Biomarker (SAF): IL4
Genes: BSF1; IL-4; BCGF1; BCGF-1; MGC79402
Study 29782224 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): Interleukin 13
Genes: IL13; NC30