TrialPanorama/TrialPanorama-database huggingface dataset:
Study 8178906 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21148045 — Pharmacodynamic Biomarker (PDY): Tyrosine-protein kinase ABL1
Genes: ABL1; ABL; JTK7
Study 21148045 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 17679042 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 11457746 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 30636504 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 7737135 — Predictive Biomarker (PRD): CP mRNA
Genes: CP
Study 31298350 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 31298350 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 19452097 — Surrogate Endpoint (SUR): Bone mineral density
Study 9010041 — Surrogate Endpoint (SUR): Serum calcium
Study 30894560 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 26269240 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 26269240 — Predictive Biomarker (PRD): CD38 mRNA
Genes: CD38
Study 26269240 — Pharmacodynamic Biomarker (PDY): Human leukocyte antigen DR
Study 21609524 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 30170687 — Predictive Biomarker (PRD): ERAS mRNA
Genes: ERAS; HRAS2; HRASP
Study 31552537 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 31429896 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31429896 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25945019 — Predictive Biomarker (PRD): MOXD1 mRNA
Genes: MOXD1; MOX; UNQ2493/PRO5780
Study 17075320 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 3675669 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 27833919 — Predictive Biomarker (PRD): ACD mRNA
Genes: ACD; PIP1; PTOP; TINT1; TPP1
Study 19365399 — Predictive Biomarker (PRD): HTR2A mRNA
Genes: HTR2A; HTR2
Study 19365399 — Predictive Biomarker (PRD): SLC6A2 mRNA
Genes: SLC6A2; NAT1; NET1; SLC6A5
Study 19365399 — Predictive Biomarker (PRD): NR3C1 mRNA
Genes: NR3C1; GRL
Study 17455472 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 7831452 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 3242576 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 3242576 — Surrogate Endpoint (SUR): Blood pressure
Study 30263038 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30263038 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30263038 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 20523304 — Surrogate Endpoint (SUR): Blood pressure
Study 16125823 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 7490173 — Safety Biomarker (SAF): L-acetylcarnitine
Study 28114587 — Predictive Biomarker (PRD): TES mRNA
Genes: TES
Study 24860934 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 21058203 — Surrogate Endpoint (SUR): Blood pressure
Study 15677734 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 15677734 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 30945979 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 30945979 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 22367073 — Predictive Biomarker (PRD): CD2 mRNA
Genes: CD2; SRBC
Study 15102866 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 22114294 — Predictive Biomarker (PRD): LPP mRNA
Genes: LPP
Study 16974197 — Surrogate Endpoint (SUR): Blood pressure
Study 11258112 — Predictive Biomarker (PRD): AR mRNA
Genes: AR; DHTR; NR3C4
Study 29847470 — Predictive Biomarker (PRD): TRPA1 mRNA
Genes: TRPA1; ANKTM1
Study 29847470 — Predictive Biomarker (PRD): TRPV1 mRNA
Genes: TRPV1; VR1
Study 27842943 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 16181164 — Surrogate Endpoint (SUR): Bone mineral density
Study 7539874 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Lactate dehydrogenase
Study 11231036 — Predictive Biomarker (PRD): CFH mRNA
Genes: CFH; HF; HF1; HF2
Study 20463287 — Predictive Biomarker (PRD): CNR1 mRNA
Genes: CNR1; CNR
Study 15331798 — Pharmacodynamic Biomarker (PDY): Complement C5
Genes: C5; CPAMD4
Study 11410193 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 7684219 — Safety Biomarker (SAF): Antithrombin-III
Genes: SERPINC1; AT3; PRO0309
Study 16754728 — Predictive Biomarker (PRD); Safety Biomarker (SAF): STAR mRNA
Genes: STAR; STARD1
Study 15449741 — Predictive Biomarker (PRD): PIP mRNA
Genes: PIP; GCDFP15; GPIP4
Study 9767362 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9767362 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 9767362 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 10367600 — Surrogate Endpoint (SUR): Blood pressure
Study 1855277 — Predictive Biomarker (PRD): PAM mRNA
Genes: PAM
Study 20042444 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 10393145 — Surrogate Endpoint (SUR): Bone mineral density
Study 8677539 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 31660791 — Predictive Biomarker (PRD): TLR8 mRNA
Genes: TLR8; UNQ249/PRO286
Study 30345906 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 30345906 — Predictive Biomarker (PRD): Hormone receptor
Study 30345906 — Predictive Biomarker (PRD): Programmed cell death 1 ligand 1
Genes: CD274; B7H1; PDCD1L1; PDCD1LG1; PDL1
Study 17443469 — Predictive Biomarker (PRD): MIF mRNA
Genes: MIF; GLIF; MMIF
Study 12478843 — Predictive Biomarker (PRD): MEST mRNA
Genes: MEST; PEG1
Study 9803048 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 19403652 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19403652 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19403652 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11286949 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 18560140 — Predictive Biomarker (PRD): MAL mRNA
Genes: MAL
Study 10485722 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 1768563 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 24888199 — Surrogate Endpoint (SUR): Blood pressure
Study 24888199 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16300417 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 12379552 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 27197855 — Surrogate Endpoint (SUR): Blood pressure
Study 25395314 — Predictive Biomarker (PRD): Ki-67
Genes: MKI67; MIB-1; PPP1R105
Study 25395314 — Safety Biomarker (SAF): let-7a
Study 17459096 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 6587751 — Surrogate Endpoint (SUR): Blood pressure
Study 29752248 — Surrogate Endpoint (SUR): Blood pressure
Study 25121612 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Endothelin-1
Genes: EDN1
Study 21548546 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 2054273 — Surrogate Endpoint (SUR): Serum LDL cholesterol
Study 2054273 — Surrogate Endpoint (SUR): Blood pressure
Study 31630182 — Surrogate Endpoint (SUR): Blood pressure
Study 28544171 — Surrogate Endpoint (SUR): Blood pressure
Study 24503429 — Predictive Biomarker (PRD): VKORC1 mRNA
Genes: VKORC1; VKOR; MSTP134; MSTP576; UNQ308/PRO351
Study 24503429 — Predictive Biomarker (PRD): CYP2C9 mRNA
Genes: CYP2C9; CYP2C10
Study 16386259 — Surrogate Endpoint (SUR): Serum triglycerides
Study 12110823 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 7750315 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 7750315 — Surrogate Endpoint (SUR): Blood pressure
Study 26425555 — Safety Biomarker (SAF): miR-155
Genes: MIR155
Study 2142109 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 19752581 — Predictive Biomarker (PRD): EP300 mRNA
Genes: EP300; P300
Study 19752581 — Predictive Biomarker (PRD): ABCC6 mRNA
Genes: ABCC6; ARA; MRP6
Study 12924804 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 12924804 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 12924804 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 12924804 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Complement C3
Genes: C3; CPAMD1
Study 12924804 — Surrogate Endpoint (SUR): Serum triglycerides
Study 6837464 — Surrogate Endpoint (SUR): Blood pressure
Study 28834955 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 25159085 — Predictive Biomarker (PRD): CNBP mRNA
Genes: CNBP; RNF163; ZNF9
Study 25159085 — Predictive Biomarker (PRD): BPI mRNA
Genes: BPI
Study 10453581 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 29851415 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 29851415 — Predictive Biomarker (PRD): CD28 mRNA
Genes: CD28
Study 18987358 — Surrogate Endpoint (SUR): Hematologic response
Study 16163098 — Surrogate Endpoint (SUR): Blood pressure
Study 12412978 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 11794427 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16326406 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 11263780 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 11263780 — Surrogate Endpoint (SUR): Serum creatinine
Study 10920881 — Predictive Biomarker (PRD): AFP mRNA
Genes: AFP; HPAFP
Study 28941216 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 28941216 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): C-X-C motif chemokine 9
Genes: CXCL9; CMK; MIG; SCYB9
Study 28941216 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-X-C motif chemokine 10
Genes: CXCL10; INP10; SCYB10
Study 28941216 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Interleukin 17
Genes: IL17A; CTLA8; IL17
Study 21056046 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 21056046 — Safety Biomarker (SAF): BDNF
Study 17094031 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9150830 — Predictive Biomarker (PRD): HPDL mRNA
Genes: HPDL; GLOXD1
Study 7893584 — Surrogate Endpoint (SUR): Blood pressure
Study 27546885 — Monitoring Biomarker (MOI): Angiopoietin-1
Genes: ANGPT1; KIAA0003
Study 17101285 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 10847258 — Surrogate Endpoint (SUR): Blood pressure
Study 8781044 — Surrogate Endpoint (SUR): Bone mineral density
Study 4018658 — Surrogate Endpoint (SUR): Cervical intraepithelial neoplasia
Study 27138110 — Surrogate Endpoint (SUR): Blood pressure
Study 30522722 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 27015912 — Surrogate Endpoint (SUR): Forced vital capacity
Study 24028546 — Surrogate Endpoint (SUR): Pathological complete response
Study 17679135 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 28323989 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 14768525 — Predictive Biomarker (PRD); Safety Biomarker (SAF): COX2 mRNA
Genes: PTGS2; COX2
Study 9096993 — Predictive Biomarker (PRD): SMS mRNA
Genes: SMS
Study 12456911 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Immunoglobulin E
Study 1365044 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 26477698 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 26477698 — Surrogate Endpoint (SUR): Bone mineral density
Study 11895556 — Monitoring Biomarker (MOI): HBV DNA
Study 9469336 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 17214176 — Monitoring Biomarker (MOI): HBV DNA
Study 14712425 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 25226824 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 20677584 — Surrogate Endpoint (SUR): Forced vital capacity
Study 21839816 — Predictive Biomarker (PRD): PPIA mRNA
Genes: PPIA; CYPA
Study 7935029 — Predictive Biomarker (PRD): SHBG mRNA
Genes: SHBG
Study 30784356 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 23775057 — Surrogate Endpoint (SUR): Blood pressure
Study 2896870 — Surrogate Endpoint (SUR): Serum alkaline phosphatase and bilirubin
Study 2896870 — Surrogate Endpoint (SUR): Serum alkaline phosphatase
Study 31973702 — Predictive Biomarker (PRD): GAD1 mRNA
Genes: GAD1; GAD; GAD67
Study 19802506 — Surrogate Endpoint (SUR): Bone mineral density
Study 16877730 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 16877730 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Vascular endothelial growth factor
Study 12940940 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 9010961 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 8656173 — Surrogate Endpoint (SUR): Serum creatinine
Study 1386374 — Surrogate Endpoint (SUR): Bone mineral density
Study 1386374 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 1386374 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31627089 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 31627089 — Surrogate Endpoint (SUR): Blood pressure
Study 23302671 — Monitoring Biomarker (MOI): Heme oxygenase 1
Genes: HMOX1; HO; HO1
Study 23302671 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 11510868 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 23623450 — Predictive Biomarker (PRD): UFD1 mRNA
Genes: UFD1; UFD1L
Study 22035462 — Surrogate Endpoint (SUR): Bone mineral density
Study 12604409 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 12604409 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9169958 — Predictive Biomarker (PRD): CRH mRNA
Genes: CRH
Study 25189490 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 22225620 — Predictive Biomarker (PRD): CXCL13 mRNA
Genes: CXCL13; BCA1; BLC; SCYB13
Study 22225620 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16505415 — Predictive Biomarker (PRD); Safety Biomarker (SAF): TP53
Genes: p53; LFS1
Study 28302532 — Predictive Biomarker (PRD); Safety Biomarker (SAF): MUC5AC mRNA
Genes: MUC5AC; MUC5
Study 26687550 — Surrogate Endpoint (SUR): Blood pressure
Study 8840744 — Surrogate Endpoint (SUR): Blood pressure
Study 27282865 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 27282865 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 19161950 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 2896635 — Surrogate Endpoint (SUR): Blood pressure
Study 30410133 — Predictive Biomarker (PRD): RETN mRNA
Genes: RETN; FIZZ3; HXCP1; RSTN; UNQ407/PRO1199
Study 28545518 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 28545518 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 28545518 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23948514 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23948514 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8320247 — Surrogate Endpoint (SUR): Serum creatinine
Study 19713429 — Predictive Biomarker (PRD): CD68 mRNA
Genes: CD68
Study 19713429 — Predictive Biomarker (PRD): FCGR3B
Genes: CD16; CD16b; FcgammaRIIIb; FcRIIIb
Study 17430734 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17430734 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 14765851 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 2691130 — Surrogate Endpoint (SUR): Serum creatinine
Study 2691130 — Surrogate Endpoint (SUR): Blood pressure
Study 30829100 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9809930 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9809930 — Surrogate Endpoint (SUR): Blood pressure
Study 8748 — Surrogate Endpoint (SUR): Blood pressure
Study 16802350 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 22820896 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 11824947 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 11824947 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 383171 — Predictive Biomarker (PRD): MERTK mRNA
Genes: MERTK; MER
Study 31698920 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 24414739 — Predictive Biomarker (PRD): Exhaled nitric oxide
Study 17043847 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 10354909 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 26508441 — Surrogate Endpoint (SUR): Blood pressure
Study 12814763 — Surrogate Endpoint (SUR): Bone mineral density
Study 12814763 — Predictive Biomarker (PRD): Intact parathyroid hormone
Study 12814763 — Surrogate Endpoint (SUR): Serum calcium
Study 9298338 — Predictive Biomarker (PRD): C6 mRNA
Genes: C6
Study 30820772 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 19687490 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 14968053 — Surrogate Endpoint (SUR): Blood pressure
Study 8325046 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 19327948 — Surrogate Endpoint (SUR): Blood pressure
Study 24880753 — Safety Biomarker (SAF): Cytochrome P450 2D6
Genes: CYP2D6; CYP2DL1
Study 11212979 — Surrogate Endpoint (SUR): Blood pressure
Study 31278695 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 19368508 — Surrogate Endpoint (SUR): Serum calcium
Study 16238680 — Predictive Biomarker (PRD): PON1 mRNA
Genes: PON1; PON
Study 16238680 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16238680 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 7597268 — Predictive Biomarker (PRD): PLA2G1B mRNA
Genes: PLA2G1B; PLA2; PLA2A; PPLA2
Study 7597268 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 1708032 — Surrogate Endpoint (SUR): Blood pressure
Study 23379631 — Predictive Biomarker (PRD): GSTM1 mRNA
Genes: GSTM1; GST1
Study 23379631 — Safety Biomarker (SAF): Glutathione S-transferase P
Genes: GSTP1; FAEES3; GST3
Study 23379631 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Nqo1 mRNA
Genes: NQO1; DIA4; NMOR1
Study 17373904 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 25896182 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 25896182 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 25896182 — Pharmacodynamic Biomarker (PDY): Cholesteryl ester transfer protein
Genes: CETP
Study 10515287 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 10515287 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 30982549 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 26298752 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 18831899 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 18831899 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 28583024 — Surrogate Endpoint (SUR): Blood pressure
Study 22561352 — Surrogate Endpoint (SUR): Blood pressure
Study 10811045 — Predictive Biomarker (PRD): LBP mRNA
Genes: LBP
Study 10811045 — Predictive Biomarker (PRD): MTTP mRNA
Genes: MTTP; MTP
Study 6091244 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 24899158 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 24899158 — Predictive Biomarker (PRD): PNP mRNA
Genes: PNP; NP
Study 24899158 — Predictive Biomarker (PRD): TG mRNA
Genes: TG
Study 18272504 — Predictive Biomarker (PRD); Safety Biomarker (SAF): DES mRNA
Genes: DES
Study 11836292 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 8960842 — Surrogate Endpoint (SUR): Blood pressure
Study 6819904 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 6819904 — Predictive Biomarker (PRD): PBX1 mRNA
Genes: PBX1; PRL
Study 22334770 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 9787142 — Predictive Biomarker (PRD): SCD mRNA
Genes: SCD; FADS5; SCD1; SCDOS
Study 7636912 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 30859363 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 23570342 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23570342 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 19184087 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 15497716 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 31957334 — Predictive Biomarker (PRD): NRM mRNA
Genes: NRM; NRM29; UNQ555/PRO1112
Study 27496969 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 27496969 — Predictive Biomarker (PRD): HS3ST2 mRNA
Genes: HS3ST2; 3OST2; UNQ2442/PRO5004