TrialPanorama/TrialPanorama-database huggingface dataset:
Study 23886632 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 21382044 — Predictive Biomarker (PRD): AMT mRNA
Genes: AMT; GCST
Study 9113632 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 30014968 — Surrogate Endpoint (SUR): Blood pressure
Study 8649628 — Surrogate Endpoint (SUR): Blood pressure
Study 8649628 — Surrogate Endpoint (SUR): Serum creatinine
Study 28700781 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 28700781 — Surrogate Endpoint (SUR): Serum potassium
Study 22045829 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 17290158 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 15625409 — Surrogate Endpoint (SUR): Blood pressure
Study 24356937 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 17469099 — Predictive Biomarker (PRD): ACR mRNA
Genes: ACR; ACRS
Study 29063827 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23751521 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9660035 — Surrogate Endpoint (SUR): Blood pressure
Study 23525448 — Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): TNF related activation protein
Genes: CD40LG; CD40L; TNFSF5; TRAP
Study 16873594 — Surrogate Endpoint (SUR): Blood pressure
Study 7669959 — Surrogate Endpoint (SUR): Blood pressure
Study 17295604 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 17295604 — Safety Biomarker (SAF): Interleukin 1
Study 11504286 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 9467533 — Predictive Biomarker (PRD): TRH mRNA
Genes: TRH
Study 9467533 — Predictive Biomarker (PRD): IGFALS mRNA
Genes: IGFALS; ALS
Study 29473354 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 29473354 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 26816234 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19952712 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 19952712 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 8917026 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8917026 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 8917026 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 2784824 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 27136906 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 25924029 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 24091311 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21623467 — Pharmacodynamic Biomarker (PDY): Superoxide dismutase Cu-Zn
Genes: SOD1
Study 27939836 — Surrogate Endpoint (SUR): Serum testosterone
Study 24335969 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15457277 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 15457277 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 24044803 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 17396057 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 17396057 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 17396057 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 27765756 — Safety Biomarker (SAF): PDCD1
Genes: CD279; PD1; hSLE1; PD-1
Study 23063263 — Predictive Biomarker (PRD): ELK3 mRNA
Genes: ELK3; NET; SAP2
Study 15691342 — Predictive Biomarker (PRD): B-lymphocyte surface antigen B4
Genes: CD19
Study 12534402 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30589533 — Predictive Biomarker (PRD): TPH2 mRNA
Genes: TPH2; NTPH
Study 30589533 — Predictive Biomarker (PRD): HTR1A mRNA
Genes: HTR1A; ADRB2RL1; ADRBRL1
Study 30589533 — Predictive Biomarker (PRD): HTR1B mRNA
Genes: HTR1B; HTR1DB
Study 30589533 — Predictive Biomarker (PRD): HTR2A mRNA
Genes: HTR2A; HTR2
Study 30589533 — Predictive Biomarker (PRD): 5HTT
Genes: SLC6A4; 5-HTT; SERT1
Study 30241302 — Predictive Biomarker (PRD): CGA mRNA
Genes: CGA
Study 26621909 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 24445737 — Surrogate Endpoint (SUR): Blood pressure
Study 19410576 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 19410576 — Predictive Biomarker (PRD): APC mRNA
Genes: APC; DP2.5
Study 15522363 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 22161999 — Predictive Biomarker (PRD): FMN1 mRNA
Genes: FMN1; FMN; LD
Study 22161999 — Predictive Biomarker (PRD): OCA2 mRNA
Genes: OCA2; D15S12; P
Study 11746320 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 31613424 — Predictive Biomarker (PRD): SP6 mRNA
Genes: SP6; KLF14
Study 21718908 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 16831828 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 14612286 — Predictive Biomarker (PRD): NXF1 mRNA
Genes: NXF1; TAP
Study 7726672 — Safety Biomarker (SAF): Interleukin 1
Study 7726672 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31600487 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31600487 — Safety Biomarker (SAF): HLA-DQA1
Genes: CELIAC1
Study 30209855 — Predictive Biomarker (PRD): MIP mRNA
Genes: MIP; AQP0
Study 25990414 — Surrogate Endpoint (SUR): Bone mineral density
Study 9146848 — Predictive Biomarker (PRD): CYP3A4 mRNA
Genes: CYP3A4; CYP3A3
Study 30458805 — Predictive Biomarker (PRD): CTSC mRNA
Genes: CTSC; CPPI
Study 23916045 — Predictive Biomarker (PRD): FH mRNA
Genes: FH
Study 12850963 — Surrogate Endpoint (SUR): Bone mineral density
Study 29952487 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 15919489 — Surrogate Endpoint (SUR): Serum triglycerides
Study 26878838 — Predictive Biomarker (PRD): ARCN1 mRNA
Genes: ARCN1; COPD
Study 19783324 — Surrogate Endpoint (SUR): Blood pressure
Study 15621801 — Predictive Biomarker (PRD): Leukocyte surface antigen Leu-16
Genes: MS4A1; CD20
Study 28304224 — Predictive Biomarker (PRD): PCSK9 mRNA
Genes: PCSK9; NARC1; PSEC0052
Study 28304224 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 23880306 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 21714857 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Neutrophil gelatinase-associated lipocalin
Genes: LCN2; HNL; NGAL
Study 21714857 — Safety Biomarker (SAF): Cystatin C
Genes: CST3
Study 19379152 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11263600 — Predictive Biomarker (PRD): MVD mRNA
Genes: MVD; MPD
Study 11263600 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 9135945 — Surrogate Endpoint (SUR): Blood pressure
Study 26689566 — Predictive Biomarker (PRD): Aurora kinase A
Genes: AURKA; AIK; AIRK1; ARK1; AURA; AYK1; BTAK; IAK1; STK15; STK6
Study 16163920 — Surrogate Endpoint (SUR): Blood pressure
Study 27894336 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27894336 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23891072 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21192262 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 7679166 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 7679166 — Surrogate Endpoint (SUR): Blood pressure
Study 24643905 — Surrogate Endpoint (SUR): Bone mineral density
Study 19941679 — Predictive Biomarker (PRD): NUCB2 mRNA
Genes: NUCB2; NEFA
Study 12660934 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 12660934 — Surrogate Endpoint (SUR): Neutralizing antibody
Study 30650445 — Safety Biomarker (SAF): Granulocyte-macrophage colony-stimulating factor
Genes: CSF2; GMCSF
Study 30650445 — Safety Biomarker (SAF): Hemoglobin scavenger receptor
Genes: CD163; M130
Study 30650445 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 30650445 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23882146 — Surrogate Endpoint (SUR): Blood pressure
Study 23882146 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15899959 — Surrogate Endpoint (SUR): Bone mineral density
Study 9718588 — Surrogate Endpoint (SUR): Blood pressure
Study 8573552 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 16448890 — Surrogate Endpoint (SUR): Blood pressure
Study 15065530 — Safety Biomarker (SAF): Cytochrome P450 2C19
Genes: CYP2C19
Study 24861959 — Surrogate Endpoint (SUR): Blood pressure
Study 21491121 — Predictive Biomarker (PRD): CD40 mRNA
Genes: CD40; TNFRSF5
Study 15224086 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 9530643 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 9530643 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 26256065 — Surrogate Endpoint (SUR): Blood pressure
Study 23146744 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15073471 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 15073471 — Surrogate Endpoint (SUR): Blood pressure
Study 30710211 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 30710211 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 21649817 — Safety Biomarker (SAF): Hyaluronic acid
Study 3098 — Surrogate Endpoint (SUR): Blood pressure
Study 29216250 — Predictive Biomarker (PRD): PYY mRNA
Genes: PYY
Study 29216250 — Pharmacodynamic Biomarker (PDY): Gastric inhibitory polypeptide
Genes: GIP
Study 26140943 — Pharmacodynamic Biomarker (PDY): Matrix metalloproteinase 9
Genes: MMP9; CLG4B
Study 26140943 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 23268367 — Predictive Biomarker (PRD): TNFSF13B mRNA
Genes: TNFSF13B; BAFF; BLYS; TALL1; TNFSF20; ZTNF4; UNQ401/PRO738
Study 23268367 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 23268367 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20961333 — Predictive Biomarker (PRD): Vitamin D-binding protein
Genes: GC
Study 20961333 — Surrogate Endpoint (SUR): Bone mineral density
Study 24850280 — Surrogate Endpoint (SUR): Exhaled carbon monoxide
Study 15820814 — Predictive Biomarker (PRD): LAD1 mRNA
Genes: LAD1; LAD
Study 12212781 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 8564348 — Surrogate Endpoint (SUR): Serum calcium
Study 10516515 — Surrogate Endpoint (SUR): Blood pressure
Study 6309542 — Surrogate Endpoint (SUR): Blood pressure
Study 29274618 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 20489741 — Predictive Biomarker (PRD): PC mRNA
Genes: PC
Study 20489741 — Predictive Biomarker (PRD): GPI mRNA
Genes: GPI
Study 15750042 — Predictive Biomarker (PRD): PDE5A mRNA
Genes: PDE5A; PDE5
Study 15750042 — Predictive Biomarker (PRD): PAH mRNA
Genes: PAH
Study 10499226 — Predictive Biomarker (PRD): SCT mRNA
Genes: SCT
Study 8544280 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 30785379 — Surrogate Endpoint (SUR): Blood pressure
Study 21422768 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 21422768 — Safety Biomarker (SAF): BDNF
Study 15163474 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15163474 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 11339401 — Surrogate Endpoint (SUR): Serum sodium
Study 9159306 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 9159306 — Surrogate Endpoint (SUR): Blood pressure
Study 31711513 — Predictive Biomarker (PRD): CCS mRNA
Genes: CCS
Study 27702823 — Predictive Biomarker (PRD): NPEPPS mRNA
Genes: NPEPPS; PSA
Study 23802920 — Predictive Biomarker (PRD): TBC1D4 mRNA
Genes: TBC1D4; AS160; KIAA0603
Study 21783046 — Surrogate Endpoint (SUR): Blood pressure
Study 16306998 — Surrogate Endpoint (SUR): Blood pressure
Study 9463204 — Predictive Biomarker (PRD): SLC12A3 mRNA
Genes: SLC12A3; NCC; TSC
Study 3486551 — Surrogate Endpoint (SUR): Blood pressure
Study 17225518 — Predictive Biomarker (PRD): HR mRNA
Genes: HR
Study 15513312 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 2478778 — Surrogate Endpoint (SUR): Blood pressure
Study 29093005 — Monitoring Biomarker (MOI): Macrophage inflammatory protein 1-alpha
Genes: CCL3; G0S19-1; MIP1A; SCYA3
Study 18192906 — Surrogate Endpoint (SUR): Blood pressure
Study 12704306 — Predictive Biomarker (PRD): C2 mRNA
Genes: C2
Study 12704306 — Monitoring Biomarker (MOI): Complement C7
Genes: C7
Study 9364618 — Predictive Biomarker (PRD): Arginine vasopressin
Genes: AVP; ARVP; VP
Study 3890394 — Surrogate Endpoint (SUR): Blood pressure
Study 27029487 — Monitoring Biomarker (MOI): Mitochondrial frataxin
Genes: FXN; FRDA; X25
Study 10857839 — Surrogate Endpoint (SUR): Blood pressure
Study 1615175 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Serum albumin
Genes: ALB; GIG20; GIG42; PRO0903; PRO1708; PRO2044; PRO2619; PRO2675; UNQ696/PRO1341
Study 24854306 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 12970006 — Predictive Biomarker (PRD): FEV mRNA
Genes: FEV; PET1
Study 31124918 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31277561 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Interleukin 6
Genes: IL6; IFNB2
Study 31277561 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 23519546 — Surrogate Endpoint (SUR): Blood pressure
Study 23519546 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 21660636 — Monitoring Biomarker (MOI): Epidermal growth factor
Genes: EGF
Study 21660636 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 21660636 — Monitoring Biomarker (MOI): Angiopoietin-1
Genes: ANGPT1; KIAA0003
Study 19172849 — Safety Biomarker (SAF); Monitoring Biomarker (MOI): Interferon gamma
Genes: IFNG
Study 27122080 — Predictive Biomarker (PRD); Monitoring Biomarker (MOI): BDNF mRNA
Genes: BDNF
Study 27122080 — Safety Biomarker (SAF): BDNF
Study 21787454 — Surrogate Endpoint (SUR): Blood pressure
Study 19031218 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 19031218 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 10027319 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 27108936 — Predictive Biomarker (PRD): SHD mRNA
Genes: SHD
Study 20962315 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 20962315 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 16258083 — Predictive Biomarker (PRD): Erbb2 tyrosine kinase receptor
Genes: ERBB2; HER2; MLN19; NEU; NGL
Study 9798136 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 9798136 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 31147675 — Predictive Biomarker (PRD): Phosphatase and tensin homolog
Genes: PTEN; MMAC1; TEP1
Study 31147675 — Predictive Biomarker (PRD): PIK3CA mRNA
Genes: PIK3CA
Study 31147675 — Predictive Biomarker (PRD): AKT1 mRNA
Genes: AKT1; PKB; RAC
Study 16721396 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 8355037 — Predictive Biomarker (PRD): Estrogen receptor
Genes: ESR1; ESR; NR3A1
Study 25711955 — Predictive Biomarker (PRD); Safety Biomarker (SAF): HP mRNA
Genes: HP
Study 23107605 — Predictive Biomarker (PRD): EPX mRNA
Genes: EPX; EPER; EPO; EPP
Study 17388006 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 17388006 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 10774248 — Predictive Biomarker (PRD): CD34 mRNA
Genes: CD34
Study 12390335 — Surrogate Endpoint (SUR): Blood pressure
Study 26418205 — Safety Biomarker (SAF): Cardiac troponin I
Genes: TNNI3; TNNC1
Study 20838058 — Predictive Biomarker (PRD): CAP1 mRNA
Genes: CAP1; CAP
Study 10804484 — Surrogate Endpoint (SUR): Blood pressure
Study 22306844 — Surrogate Endpoint (SUR): Blood pressure
Study 9536505 — Surrogate Endpoint (SUR): Blood pressure
Study 19367322 — Predictive Biomarker (PRD): BRCA1 mRNA
Genes: BRCA1; RNF53
Study 15042116 — Surrogate Endpoint (SUR): Blood pressure
Study 7866680 — Predictive Biomarker (PRD): POMC
Genes: MSH; POC; CLIP; ACTH; NPP; LPH
Study 27937096 — Predictive Biomarker (PRD): Proto-oncogene c-Met
Genes: MET
Study 27937096 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Epidermal growth factor receptor
Genes: EGFR; ERBB; ERBB1; HER1
Study 26664397 — Predictive Biomarker (PRD): SNAP25 mRNA
Genes: SNAP25; SNAP
Study 60566 — Surrogate Endpoint (SUR): Blood pressure
Study 31749051 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Vascular endothelial growth factor A
Genes: VEGFA; VEGF
Study 7954529 — Safety Biomarker (SAF): Interleukin 2
Genes: IL2
Study 31943168 — Predictive Biomarker (PRD); Safety Biomarker (SAF): White blood cell
Study 23532888 — Predictive Biomarker (PRD): KRAS mRNA
Genes: KRAS; KRAS2; RASK2
Study 18826858 — Predictive Biomarker (PRD): CD63 mRNA
Genes: CD63; MLA1; TSPAN30
Study 18826858 — Safety Biomarker (SAF): von Willebrand factor
Genes: VWF; F8VWF
Study 17121038 — Safety Biomarker (SAF): Natriuretic peptides A
Genes: NPPA; ANP; PND
Study 27555998 — Predictive Biomarker (PRD): CDA mRNA
Genes: CDA; CDD
Study 24814857 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Intercellular adhesion molecule 1
Genes: ICAM1
Study 10998029 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 8868605 — Predictive Biomarker (PRD): ESD mRNA
Genes: ESD
Study 2442536 — Surrogate Endpoint (SUR): Blood pressure
Study 29807824 — Safety Biomarker (SAF): Thyroid stimulating hormone
Study 19941694 — Predictive Biomarker (PRD); Safety Biomarker (SAF): FGA mRNA
Genes: FGA
Study 18272475 — Predictive Biomarker (PRD): GEM mRNA
Genes: GEM; KIR
Study 26785372 — Surrogate Endpoint (SUR): Plasma ammonia
Study 18192850 — Surrogate Endpoint (SUR): Blood pressure
Study 18192850 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 16644641 — Surrogate Endpoint (SUR): Blood pressure
Study 27596244 — Surrogate Endpoint (SUR): Blood pressure
Study 21029001 — Surrogate Endpoint (SUR): Blood pressure
Study 11176980 — Predictive Biomarker (PRD): AMD1 mRNA
Genes: AMD1; AMD
Study 7967272 — Predictive Biomarker (PRD): MB mRNA
Genes: MB
Study 3480076 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 8681490 — Surrogate Endpoint (SUR): Blood pressure
Study 31136288 — Surrogate Endpoint (SUR): Blood pressure
Study 20702114 — Pharmacodynamic Biomarker (PDY): Angiotensinogenase renin
Genes: REN
Study 20702114 — Surrogate Endpoint (SUR): Blood pressure
Study 31392826 — Predictive Biomarker (PRD): AATK mRNA
Genes: AATK; AATYK; KIAA0641; LMR1; LMTK1
Study 31392826 — Predictive Biomarker (PRD): CD4 mRNA
Genes: CD4
Study 27489178 — Safety Biomarker (SAF): Ornithine transcarbamylase
Genes: OTC
Study 21892200 — Predictive Biomarker (PRD): CYP1A2 mRNA
Genes: CYP1A2
Study 18028134 — Predictive Biomarker (PRD): CD14 mRNA
Genes: CD14
Study 18028134 — Predictive Biomarker (PRD); Safety Biomarker (SAF): Interleukin 8
Genes: CXCL8; IL8
Study 18028134 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-C motif chemokine 2
Genes: CCL2; MCP1; SCYA2
Study 16157451 — Predictive Biomarker (PRD): TLR4 mRNA
Genes: TLR4
Study 16157451 — Predictive Biomarker (PRD): Apolipoprotein E
Genes: APOE
Study 3375576 — Surrogate Endpoint (SUR): Serum calcium
Study 8203510 — Predictive Biomarker (PRD): ANG mRNA
Genes: ANG; RNASE5
Study 31217388 — Predictive Biomarker (PRD): CPM mRNA
Genes: CPM
Study 30389671 — Pharmacodynamic Biomarker (PDY): Angiotensin-converting enzyme
Genes: ACE; DCP; DCP1
Study 26243165 — Surrogate Endpoint (SUR): Blood pressure
Study 14689405 — Surrogate Endpoint (SUR): Pulmonary vascular resistance
Study 31496160 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 31496160 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): Tumor necrosis factor
Genes: TNF; TNFA; TNFSF2
Study 31496160 — Safety Biomarker (SAF): B-type natriuretic peptide
Genes: NPPB
Study 19781418 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1
Study 16769962 — Predictive Biomarker (PRD); Pharmacodynamic Biomarker (PDY): Microtubule-associated protein tau
Genes: MAPT; MAPTL; MTBT1; TAU
Study 15579760 — Pharmacodynamic Biomarker (PDY): High density lipoprotein cholesterol
Study 15579760 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 15579760 — Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY): Free fatty acids
Study 11416112 — Safety Biomarker (SAF): Plasminogen activator inhibitor
Genes: SERPINE1; PAI1; PLANH1
Study 28444742 — Surrogate Endpoint (SUR): Platelet count response
Study 23174861 — Pharmacodynamic Biomarker (PDY): Low-density lipoprotein
Study 21763463 — Predictive Biomarker (PRD); Safety Biomarker (SAF); Pharmacodynamic Biomarker (PDY); Monitoring Biomarker (MOI): C-reactive protein
Genes: CRP; PTX1