TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT05132569

Adverse event: Dizziness
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 3 at risk

Adverse event: Head injury
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 3 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 3 at risk

Adverse event: Upper respiratory tract infection
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 3 at risk

Adverse event: Increased tendency to bruise
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 3 at risk

Adverse event: Hyperuricaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 3 at risk

Adverse event: Abdominal pain upper
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 3 at risk

Adverse event: Hepatic function abnormal
Serious: no
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 3 at risk

Adverse event: Muscle spasms
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 3 at risk

Adverse event: Blood creatine phosphokinase increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 3 at risk

Adverse event: Haemoglobin decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 3 at risk

Adverse event: COVID-19 pneumonia
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 5 at risk

Adverse event: Abdominal pain upper
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 5 at risk

Adverse event: Toothache
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 5 at risk

Adverse event: Dry skin
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 5 at risk

Adverse event: Bilirubin conjugated increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 5 at risk

Adverse event: Basal cell carcinoma
Serious: no
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 5 at risk

Adverse event: Thermal burn
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 5 at risk

Adverse event: Oral herpes
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 5 at risk
Study: NCT05132699

Adverse event: Gastrointestinal Issues
Serious: no
Organ System: Gastrointestinal disorders
Notes: diarrhea, cramps, nausea
Frequency: 4 affected / 11 at risk

Adverse event: Emotional disorder
Serious: no
Organ System: Psychiatric disorders
Notes: increased emotional distress, anger, emotional numbness
Frequency: 3 affected / 11 at risk

Adverse event: Fatigue
Serious: no
Organ System: Psychiatric disorders
Notes: fatigue attributed to prolonged exposure
Frequency: 2 affected / 11 at risk

Adverse event: Sleep disorder
Serious: no
Organ System: Psychiatric disorders
Notes: increased nightmares and increased difficulty falling/staying asleep
Frequency: 4 affected / 11 at risk

Adverse event: Somnolence
Serious: no
Organ System: Nervous system disorders
Notes: drowsiness attributed to study drug
Frequency: 1 affected / 11 at risk

Adverse event: Physiological Arousal
Serious: no
Organ System: Psychiatric disorders
Notes: Increased physiological arousal attributed to prolonged exposure.
Frequency: 1 affected / 11 at risk

Adverse event: Gastrointestinal Issues
Serious: no
Organ System: Gastrointestinal disorders
Notes: diarrhea, cramps, nausea
Frequency: 2 affected / 10 at risk

Adverse event: Emotional disorder
Serious: no
Organ System: Psychiatric disorders
Notes: increased emotional distress, anger, emotional numbness
Frequency: 1 affected / 10 at risk

Adverse event: Fatigue
Serious: no
Organ System: Psychiatric disorders
Notes: fatigue attributed to prolonged exposure
Frequency: 3 affected / 10 at risk

Adverse event: Sensation from study drug
Serious: no
Organ System: General disorders
Notes: instant burning/warm sensation when taking study drug
Frequency: 2 affected / 10 at risk

Adverse event: Appetite Increase
Serious: no
Organ System: General disorders
Frequency: 1 affected / 10 at risk

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Increased joint pain in knee attributed to stopping medication following participation
Frequency: 1 affected / 10 at risk
Study: NCT05133323

Adverse event: Sympathetic posterior cervical syndrome
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 97 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 7 affected / 97 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 7 affected / 97 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 5 affected / 97 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 46 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 2 affected / 46 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 94 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 4 affected / 94 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 1 affected / 94 at risk
Study: NCT05133739

Adverse event: COVID-19 INFECTION
Serious: yes
Organ System: Infections and infestations
Notes: Not related to the study device or study procedure
Frequency: 1 affected / 152 at risk

Adverse event: Injection site mass
Serious: no
Organ System: General disorders
Frequency: 17 affected / 152 at risk

Adverse event: Injection site induration
Serious: no
Organ System: General disorders
Frequency: 8 affected / 152 at risk

Adverse event: Injection site pain
Serious: no
Organ System: General disorders
Frequency: 5 affected / 152 at risk

Adverse event: Injection site discolouration
Serious: no
Organ System: General disorders
Frequency: 5 affected / 152 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 21 affected / 152 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 9 affected / 152 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 152 at risk

Adverse event: COMPLICATIONS FROM HERNIA REPAIR SURGERY
Serious: yes
Organ System: Injury, poisoning and procedural complications
Notes: not related to study device or study procedure
Frequency: 1 affected / 49 at risk

Adverse event: Transient ischaemic attack
Serious: yes
Organ System: Nervous system disorders
Notes: Not related to the study device or study procedure
Frequency: 1 affected / 49 at risk

Adverse event: P16 POSITIVE OROPHARYNGEAL CANCER
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Notes: Not related to the study device or study procedure
Frequency: 1 affected / 49 at risk

Adverse event: Injection site mass
Serious: no
Organ System: General disorders
Frequency: 3 affected / 49 at risk

Adverse event: Injection site induration
Serious: no
Organ System: General disorders
Frequency: 5 affected / 49 at risk

Adverse event: Injection site pain
Serious: no
Organ System: General disorders
Frequency: 1 affected / 49 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 5 affected / 49 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 49 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 49 at risk
Study: NCT05134649

Adverse event: Cellulitis
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 292 at risk

Adverse event: Hyponatraemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 292 at risk

Adverse event: Injection site bruising
Serious: no
Organ System: General disorders
Frequency: 12 affected / 292 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 22 affected / 292 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 12 affected / 292 at risk
Study: NCT05134974

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Frequency: 26 affected / 244 at risk

Adverse event: Instillation site erythema
Serious: no
Organ System: General disorders
Frequency: 9 affected / 244 at risk

Adverse event: Dysgeusia
Serious: no
Organ System: Nervous system disorders
Frequency: 8 affected / 244 at risk
Study: NCT05135156

Adverse event: Possible suicidality endorsed on PHQ-9
Serious: no
Organ System: Psychiatric disorders
Notes: For the purposes of this study, participant report of possible suicidality on the PHQ-9 (positive response to question #9) is an immediately reportable AE, even if it is not an SAE. PHQ-9 is only administered during Zoom study visits.
Frequency: 2 affected / 25 at risk

Adverse event: Possible suicidality endorsed on PHQ-9
Serious: no
Organ System: Psychiatric disorders
Notes: For the purposes of this study, participant report of possible suicidality on the PHQ-9 (positive response to question #9) is an immediately reportable AE, even if it is not an SAE. PHQ-9 is only administered during Zoom study visits.
Frequency: 1 affected / 25 at risk
Study: NCT05135650

Adverse event: Death
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal hemorrhage is cause of death. Determined to not be related to investigation product.
Frequency: 1 affected / 20 at risk

Adverse event: Hypertension stage 2
Serious: no
Organ System: Cardiac disorders
Notes: Occurred following infusion or day after infusion. Unknown if related to investigation product.
Frequency: 2 affected / 20 at risk

Adverse event: Paraesthesia
Serious: no
Organ System: Injury, poisoning and procedural complications
Notes: Tingling of arms and chest during product infusion. Paused infusion and improved without additional intervention. Unknown if related to product infusion.
Frequency: 1 affected / 20 at risk
Study: NCT05135754

Adverse event: Patient was admitted into the hospital for subarachnoid hemorrhage and encephalitis
Serious: yes
Organ System: Nervous system disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Low Neutrophils
Serious: yes
Organ System: Blood and lymphatic system disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Bleeding Stoma
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Dehydration
Serious: yes
Organ System: Metabolism and nutrition disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Diarrhoea
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Vomiting
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Admitted to hospital as a result for producing high output black stoma contents
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Abdominal pain
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Intestinal Blockage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Intestinal infection
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Not related to Test Product (Assessed by investigators)
Frequency: 1 affected / 100 at risk

Adverse event: Skin redness and irritation
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Assessed by investigators to be possibly, probably, or causally related to the Test Product
Frequency: 18 affected / 100 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Notes: Not related to Test Product; Not related to Procedure
Frequency: 6 affected / 100 at risk
Study: NCT05136170

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 44 at risk

Adverse event: Eye discharge
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 44 at risk

Adverse event: Eye irritation
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 44 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Frequency: 21 affected / 44 at risk

Adverse event: Photophobia
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 44 at risk

Adverse event: Swelling of eyelid
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 44 at risk

Adverse event: Vision blurred
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 44 at risk

Adverse event: Eyelid pain
Serious: no
Organ System: Eye disorders
Frequency: 7 affected / 44 at risk

Adverse event: Rib fracture
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 2 affected / 44 at risk

Adverse event: SARS-CoV-2 test positive
Serious: no
Organ System: Investigations
Frequency: 2 affected / 44 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 3 affected / 44 at risk

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 40 at risk

Adverse event: Dry eye
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 40 at risk

Adverse event: Eye discharge
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 40 at risk

Adverse event: Eye irritation
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 40 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Frequency: 4 affected / 40 at risk

Adverse event: Foreign body sensation in eyes
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 40 at risk

Adverse event: Swelling of eyelid
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 40 at risk

Adverse event: Vision blurred
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 40 at risk

Adverse event: SARS-CoV-2 test positive
Serious: no
Organ System: Investigations
Frequency: 1 affected / 40 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 4 affected / 40 at risk
Study: NCT05136417

Adverse event: Gastrointestinal bleeding requiring transfusion
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 100 at risk

Adverse event: Procedural-related stroke
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 100 at risk

Adverse event: Access site hematoma
Serious: no
Organ System: General disorders
Frequency: 5 affected / 100 at risk

Adverse event: Post procedural haemorrhage
Serious: no
Organ System: General disorders
Frequency: 3 affected / 100 at risk

Adverse event: Pericarditis
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 100 at risk

Adverse event: Myocardial infarction
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 100 at risk
Study: NCT05136443

Adverse event: Steroid induced intraocular pressure elevation
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 70 at risk

Adverse event: Instillation site discomfort
Serious: no
Organ System: Eye disorders
Notes: Ocular discomfort associated with instillation of study eye drop
Frequency: 2 affected / 70 at risk
Study: NCT05136690

Adverse event: Vertigo
Serious: no
Organ System: Ear and labyrinth disorders
Frequency: 1 affected / 37 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 37 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 37 at risk

Adverse event: Application site pruritus
Serious: no
Organ System: General disorders
Frequency: 3 affected / 37 at risk

Adverse event: Somnolence
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 37 at risk

Adverse event: Erythema
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 37 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 37 at risk

Adverse event: COVID-19
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 38 at risk

Adverse event: Alanine aminotransferase increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 38 at risk

Adverse event: Aspartate aminotransferase increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 38 at risk

Adverse event: White blood cell count decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 38 at risk

Adverse event: Dizziness
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 38 at risk
Study: NCT05137002

Adverse event: Hyperkalaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 3 affected / 64 at risk

Adverse event: SARS-CoV-2 test positive
Serious: no
Organ System: Investigations
Frequency: 2 affected / 64 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 64 at risk

Adverse event: SARS-CoV-2 test positive
Serious: no
Organ System: Investigations
Frequency: 4 affected / 63 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 63 at risk

Adverse event: Acute myocardial infarction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 62 at risk

Adverse event: Hyperkalaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 5 affected / 62 at risk

Adverse event: SARS-CoV-2 test positive
Serious: no
Organ System: Investigations
Frequency: 1 affected / 62 at risk

Adverse event: Acute respiratory failure
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 60 at risk

Adverse event: Hyperkalaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 3 affected / 60 at risk

Adverse event: Hyperglycaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 213 at risk

Adverse event: Dizziness
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 213 at risk

Adverse event: Hypertensive urgency
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 213 at risk

Adverse event: Bradycardia
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 213 at risk

Adverse event: Hyperkalaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 6 affected / 213 at risk
Study: NCT05137041

Adverse event: Application site erythema
Serious: no
Organ System: General disorders
Frequency: 2 affected / 114 at risk

Adverse event: Application site irritation
Serious: no
Organ System: General disorders
Frequency: 1 affected / 114 at risk

Adverse event: Application site pain
Serious: no
Organ System: General disorders
Frequency: 2 affected / 114 at risk

Adverse event: Application site paraesthesia
Serious: no
Organ System: General disorders
Frequency: 1 affected / 114 at risk

Adverse event: Application site pruritus
Serious: no
Organ System: General disorders
Frequency: 7 affected / 114 at risk

Adverse event: Gastrointestinal infection
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 114 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 114 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 114 at risk

Adverse event: Muscle tightness
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 114 at risk

Adverse event: Spinal pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 114 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 114 at risk

Adverse event: Erythema
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 114 at risk

Adverse event: Pruritus
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 114 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 107 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 107 at risk

Adverse event: Contusion
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 107 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 107 at risk

Adverse event: Sleep disorder
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 107 at risk