Study: NCT00272038

Adverse event: Chest pain
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 29 at risk

Adverse event: Dyspnoea
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Hypoxia
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Haematuria
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 5 affected / 29 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Renal failure
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 29 at risk

Adverse event: Cardiac failure congestive
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 29 at risk

Adverse event: Asthenia
Serious: yes
Organ System: General disorders
Frequency: 2 affected / 29 at risk

Adverse event: Involuntary Movement of Hands and Arms
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 29 at risk

Adverse event: Dehydration
Serious: yes
Organ System: General disorders
Frequency: 2 affected / 29 at risk

Adverse event: Pneumonia
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Pulmonary Emboli
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Diarrhoea
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Intestinal obstruction
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Decompensation
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 29 at risk

Adverse event: Spinal cord compression
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 29 at risk

Adverse event: Cellulitis
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 29 at risk

Adverse event: Low Creatinine Grade 3 & 4
Serious: no
Organ System: Renal and urinary disorders
Frequency: 2 affected / 29 at risk

Adverse event: Alkaline Phosphatase High Grade 3 & 4
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 29 at risk

Adverse event: Fatigue Grade 3 & 4
Serious: no
Organ System: General disorders
Frequency: 2 affected / 29 at risk

Adverse event: Pneumonia Grade 3 & 4
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 29 at risk

Adverse event: Rash Grade 3 & 4
Serious: no
Organ System: General disorders
Frequency: 2 affected / 29 at risk

Adverse event: Diarrhea Grade 3 & 4
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 29 at risk

Adverse event: Aspartate Aminotransferase Elevated Grade 1 - 4
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 29 at risk

Adverse event: Anemia Grade 1 & 2
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 12 affected / 29 at risk

Adverse event: Arthralgia Grade 1 & 2
Serious: no
Organ System: Nervous system disorders
Frequency: 9 affected / 29 at risk

Adverse event: Appetite decreased Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 15 affected / 29 at risk

Adverse event: Anxiety Grade 1 & 2
Serious: no
Organ System: Renal and urinary disorders
Frequency: 9 affected / 29 at risk

Adverse event: Alkaline Phosphatase Increased Grade 1 & 2
Serious: no
Organ System: Renal and urinary disorders
Frequency: 3 affected / 29 at risk

Adverse event: Bruises easily
Serious: no
Organ System: Vascular disorders
Frequency: 5 affected / 29 at risk

Adverse event: Calcium Low Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 6 affected / 29 at risk

Adverse event: Constipation Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5 affected / 29 at risk

Adverse event: Chest Pain Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 4 affected / 29 at risk

Adverse event: Chills Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 5 affected / 29 at risk

Adverse event: Cough Grade 1 & 2
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 5 affected / 29 at risk

Adverse event: Dsynea on Exertion Grade 1 & 2
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 3 affected / 29 at risk

Adverse event: Depression Grade 1 & 2
Serious: no
Organ System: Psychiatric disorders
Frequency: 10 affected / 29 at risk

Adverse event: Dehydration Grade 1 - 4
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5 affected / 29 at risk

Adverse event: Diarrhea Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 22 affected / 29 at risk

Adverse event: Edema Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 4 affected / 29 at risk

Adverse event: Fatigue Grade 1 - 4
Serious: no
Organ System: General disorders
Frequency: 14 affected / 29 at risk

Adverse event: Fever Grade 1 & 2
Serious: no
Organ System: Infections and infestations
Frequency: 4 affected / 29 at risk

Adverse event: Fungal Infection Grade 1 & 2
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 29 at risk

Adverse event: Gastroesophageal Reflux Disease Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 29 at risk

Adverse event: Hand Foot Syndrome Grade 1 - 4
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 3 affected / 29 at risk

Adverse event: Hematuria Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 5 affected / 29 at risk

Adverse event: Hemoptesis Grade 1 & 2
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 3 affected / 29 at risk

Adverse event: Headache Grade 1 & 2
Serious: no
Organ System: Nervous system disorders
Frequency: 6 affected / 29 at risk

Adverse event: Hot Flashes Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 5 affected / 29 at risk

Adverse event: Hives Grade 1 & 2
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 5 affected / 29 at risk

Adverse event: Hyperglycemia Grade 1 - 4
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 6 affected / 29 at risk

Adverse event: Infection Grade 1 & 2
Serious: no
Organ System: Infections and infestations
Frequency: 7 affected / 29 at risk

Adverse event: Insomnia Grade 1 & 2
Serious: no
Organ System: Psychiatric disorders
Frequency: 5 affected / 29 at risk

Adverse event: Itching Grade 1 & 2
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 7 affected / 29 at risk

Adverse event: Lymphopenia Grade 1 - 4
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 6 affected / 29 at risk

Adverse event: Lightheadedness Grade 1 & 2
Serious: no
Organ System: Nervous system disorders
Frequency: 8 affected / 29 at risk

Adverse event: Libido decreased Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 4 affected / 29 at risk

Adverse event: Mouth Sores Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 7 affected / 29 at risk

Adverse event: Mouth Dry Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 11 affected / 29 at risk

Adverse event: Nail changes Grade 1 & 2
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 29 at risk

Adverse event: Potassium Decreased Grade 1 & 2
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 29 at risk

Adverse event: Potassium Increased Grade 1 & 2
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 29 at risk

Adverse event: Protein Decreased Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 29 at risk

Adverse event: Renal Insufficiency Grade 1 - 4
Serious: no
Organ System: Renal and urinary disorders
Frequency: 3 affected / 29 at risk

Adverse event: Swallowing Difficulty Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 29 at risk

Adverse event: Sodium Decreased Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 29 at risk

Adverse event: Taste Change Grade 1 & 2
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 29 at risk

Adverse event: Urinary Tract Infection Grade 1 & 2
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 29 at risk

Adverse event: Wheezing Grade 1 & 2
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 2 affected / 29 at risk

Adverse event: Blood Urea Nitrogen increased Grade 1 & 2
Serious: no
Organ System: Renal and urinary disorders
Frequency: 2 affected / 29 at risk

Adverse event: Creatinine Increased Grade 1 & 2
Serious: no
Organ System: Renal and urinary disorders
Frequency: 2 affected / 29 at risk

Adverse event: Eyes dry Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 2 affected / 29 at risk

Adverse event: Eyes Watery Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 2 affected / 29 at risk

Adverse event: Memory Loss Grade 1 & 2
Serious: no
Organ System: General disorders
Frequency: 2 affected / 29 at risk