TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT01738477

Adverse event: Dysmenorrhoea
Serious: no
Organ System: Reproductive system and breast disorders
Frequency: 2 affected / 37 at risk

Adverse event: Erythema
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 15 affected / 37 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 8 affected / 37 at risk

Adverse event: Gastrointestinal disorder
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 37 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 11 affected / 37 at risk

Adverse event: Myalgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 37 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Frequency: 21 affected / 37 at risk

Adverse event: Swelling
Serious: no
Organ System: General disorders
Frequency: 7 affected / 37 at risk

Adverse event: Dysmenorrhoea
Serious: no
Organ System: Reproductive system and breast disorders
Frequency: 2 affected / 128 at risk

Adverse event: Erythema
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 47 affected / 128 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 38 affected / 128 at risk

Adverse event: Gastrointestinal disorder
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 11 affected / 128 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 46 affected / 128 at risk

Adverse event: Myalgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 128 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Frequency: 97 affected / 128 at risk

Adverse event: Swelling
Serious: no
Organ System: General disorders
Frequency: 30 affected / 128 at risk
Study: NCT01738581

Adverse event: Abnormal Sleep Pattern
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 5 at risk

Adverse event: Decreased balance
Serious: no
Organ System: Nervous system disorders
Notes: Feeling dizzy, off-balance
Frequency: 2 affected / 5 at risk

Adverse event: Mood altered
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 5 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Notes: Mild headache sometimes accompanied by dizziness
Frequency: 2 affected / 4 at risk

Adverse event: Neck pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 4 at risk
Study: NCT01738672

Adverse event: Pain
Serious: no
Organ System: General disorders
Frequency: 16 affected / 16 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 7 affected / 16 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 16 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 16 at risk

Adverse event: Sinus bradycardia
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 16 at risk

Adverse event: Sinus tachycardia
Serious: no
Organ System: Cardiac disorders
Frequency: 3 affected / 16 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 2 affected / 16 at risk

Adverse event: Hypotension
Serious: no
Organ System: Vascular disorders
Frequency: 3 affected / 16 at risk
Study: NCT01738919

Adverse event: Secundary subluxation
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 3 affected / 14 at risk
Study: NCT01738984

Adverse event: Emergency appendectomy
Serious: no
Organ System: Surgical and medical procedures
Frequency: 1 affected / 250 at risk

Adverse event: Broken foot bone
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 250 at risk

Adverse event: Torn meniscus
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 250 at risk

Adverse event: Emergency appendectomy
Serious: no
Organ System: Surgical and medical procedures
Frequency: 1 affected / 249 at risk

Adverse event: Surgery for herniated disk, pinched nerve
Serious: no
Organ System: Surgical and medical procedures
Frequency: 1 affected / 249 at risk
Study: NCT01739361

Adverse event: AST or ALT >400 U/L
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 2 affected / 21 at risk

Adverse event: AST or ALT >400 U/L
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 23 at risk
Study: NCT01740128

Adverse event: Skin abrasion
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 10 at risk

Adverse event: Skin abrasion
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 3 affected / 11 at risk
Study: NCT01740154

Adverse event: Pain
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 13 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 12 affected / 13 at risk
Study: NCT01740362

Adverse event: Tooth disorder
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 6 at risk

Adverse event: Respiratory tract infection
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 2 affected / 6 at risk

Adverse event: Hypertension
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 6 at risk
Study: NCT01740388

Adverse event: Conjunctivitis
Serious: no
Organ System: Eye disorders
Notes: Fellow Eye
Frequency: 2 affected / 64 at risk

Adverse event: Conjunctivitis
Serious: no
Organ System: Eye disorders
Notes: Fellow Eye
Frequency: 1 affected / 72 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Notes: Treated Eye
Frequency: 2 affected / 72 at risk
Study: NCT01740401

Adverse event: Lipase elevation
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 10 at risk

Adverse event: Amylase elevation
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 10 at risk

Adverse event: Diarrhoea
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 10 at risk

Adverse event: Hypothyroidism
Serious: yes
Organ System: Endocrine disorders
Frequency: 1 affected / 10 at risk

Adverse event: Embolism
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 10 at risk

Adverse event: Decreased appetite
Serious: no
Organ System: General disorders
Frequency: 1 affected / 10 at risk

Adverse event: Abdominal cramping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 10 at risk

Adverse event: Depigmentation
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 10 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 10 at risk

Adverse event: Lower back discomfort
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 10 at risk

Adverse event: Erythemia
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 10 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 4 affected / 10 at risk

Adverse event: Nausea
Serious: no
Organ System: General disorders
Frequency: 3 affected / 10 at risk

Adverse event: Nasal congestion
Serious: no
Organ System: General disorders
Frequency: 2 affected / 10 at risk

Adverse event: Pain
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 10 at risk

Adverse event: Pruritus
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 10 at risk
Study: NCT01740414

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 3 affected / 12 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 12 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 12 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 7 affected / 16 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 16 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 16 at risk

Adverse event: Fatigue
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 16 at risk

Adverse event: Back pain
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 16 at risk
Study: NCT01740596

Adverse event: Major Infection
Serious: yes
Organ System: Infections and infestations
Notes: Major infection: localized non-device, percutaneous site and/or pocket, or sepsis
Frequency: 6 affected / 19 at risk

Adverse event: Cardiac Disorders
Serious: yes
Organ System: Cardiac disorders
Notes: Cardiac arrhythmias, myocardial infarction, pericardial fluid collection
Frequency: 11 affected / 19 at risk

Adverse event: Worsening Heart Failure
Serious: yes
Organ System: Cardiac disorders
Frequency: 13 affected / 19 at risk

Adverse event: Renal or Neuro Dysfunction
Serious: yes
Organ System: General disorders
Frequency: 8 affected / 19 at risk

Adverse event: Respiratory failure
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 19 at risk

Adverse event: Device malfunction
Serious: yes
Organ System: Product Issues
Frequency: 1 affected / 19 at risk

Adverse event: Cardiac Disorders
Serious: no
Organ System: Cardiac disorders
Notes: Cardiac arrhythmias, bleeding
Frequency: 4 affected / 19 at risk

Adverse event: General Disorders
Serious: no
Organ System: General disorders
Notes: Hepatic dysfunction
Frequency: 4 affected / 19 at risk

Adverse event: Infection
Serious: no
Organ System: Infections and infestations
Notes: Infection
Frequency: 4 affected / 19 at risk

Adverse event: Major Infection
Serious: yes
Organ System: Infections and infestations
Notes: Major infection: localized non-device, percutaneous site and/or pocket, or sepsis
Frequency: 3 affected / 19 at risk

Adverse event: Cardiac Disorders
Serious: yes
Organ System: Cardiac disorders
Notes: Cardiac arrhythmias, myocardial infarction, pericardial fluid collection
Frequency: 10 affected / 19 at risk

Adverse event: Worsening Heart Failure
Serious: yes
Organ System: Cardiac disorders
Frequency: 13 affected / 19 at risk

Adverse event: Renal or Neuro Dysfunction
Serious: yes
Organ System: General disorders
Frequency: 5 affected / 19 at risk

Adverse event: General Disorders
Serious: no
Organ System: General disorders
Notes: Hepatic dysfunction
Frequency: 1 affected / 19 at risk
Study: NCT01740713

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 6 at risk

Adverse event: Infantile spitting up
Serious: no
Organ System: Pregnancy, puerperium and perinatal conditions
Frequency: 2 affected / 7 at risk
Study: NCT01741272

Adverse event: Non re-tear complications
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: all complications (pain, stiffnes, infection etc) were listed as a non re-tear complication and were not divided into seperate categories.
Frequency: 20 affected / 92 at risk

Adverse event: Non re-tear complications
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: all complications (pain, stiffnes, infection etc) were listed as a non re-tear complication and were not divided into seperate categories.
Frequency: 17 affected / 97 at risk
Study: NCT01741688

Adverse event: Cholelithiasis
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 16 at risk

Adverse event: Keratitis
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 16 at risk

Adverse event: Ulcerative keratitis
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 16 at risk

Adverse event: Influenza
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 16 at risk

Adverse event: Migraine
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 16 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 16 at risk

Adverse event: Urinary tract infection
Serious: no
Organ System: Renal and urinary disorders
Frequency: 1 affected / 16 at risk
Study: NCT01741701

Adverse event: insomnia/stimulant
Serious: no
Organ System: General disorders
Notes: Subjects had difficulty sleeping and felt jittery - described as a stimulant effect by one
Frequency: 3 affected / 18 at risk

Adverse event: Worsening of Parkinson's disease
Serious: no
Organ System: Nervous system disorders
Frequency: 7 affected / 18 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 18 at risk

Adverse event: Fatigue
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 18 at risk

Adverse event: Dizziness
Serious: no
Organ System: General disorders
Frequency: 1 affected / 18 at risk

Adverse event: Cognitive worsening
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 18 at risk

Adverse event: insomnia/stimulant
Serious: no
Organ System: General disorders
Notes: Subjects had difficulty sleeping and felt jittery - described as a stimulant effect by one
Frequency: 1 affected / 15 at risk

Adverse event: Worsening of Parkinson's disease
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 15 at risk

Adverse event: Cognitive worsening
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 15 at risk

Adverse event: Increased urination
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 15 at risk
Study: NCT01742338

Adverse event: Chronic obstructive pulmonary disease
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: COPD exacerbation requiring admission to the hosptial
Frequency: 2 affected / 42 at risk

Adverse event: Theraputic Instensification
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Required additional or increased dosage of medication
Frequency: 12 affected / 43 at risk

Adverse event: Chronic obstructive pulmonary disease
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: COPD exacerbation requiring admission to the hosptial
Frequency: 2 affected / 39 at risk

Adverse event: Theraputic Instensification
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Required additional or increased dosage of medication
Frequency: 10 affected / 39 at risk
Study: NCT01742832

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 1 affected / 19 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 19 at risk

Adverse event: Sexual side effects
Serious: no
Organ System: General disorders
Frequency: 1 affected / 19 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 23 at risk
Study: NCT01742897

Adverse event: Nausea
Serious: no
Organ System: General disorders
Frequency: 7 affected / 33 at risk

Adverse event: Vomiting
Serious: no
Organ System: General disorders
Frequency: 7 affected / 33 at risk

Adverse event: Dizziness
Serious: no
Organ System: General disorders
Frequency: 2 affected / 33 at risk
Study: NCT01743001

Adverse event: Acute kidney injury
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 114 at risk

Adverse event: Atrial fibrillation
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 114 at risk

Adverse event: Dizziness
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 114 at risk

Adverse event: Endocarditis
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 114 at risk

Adverse event: Pneumonia
Serious: yes
Organ System: Infections and infestations
Frequency: 2 affected / 114 at risk

Adverse event: Respiratory failure
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 114 at risk

Adverse event: Right ventricular failure
Serious: yes
Organ System: Cardiac disorders
Frequency: 3 affected / 114 at risk

Adverse event: Septic shock
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 114 at risk

Adverse event: Transient ischaemic attack
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 114 at risk

Adverse event: Bronchitis
Serious: no
Organ System: Infections and infestations
Frequency: 6 affected / 114 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 13 affected / 114 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 114 at risk

Adverse event: Upper respiratory tract infection
Serious: no
Organ System: Infections and infestations
Frequency: 11 affected / 114 at risk

Adverse event: Atrial fibrillation
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 112 at risk

Adverse event: Cardiac failure chronic
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 112 at risk

Adverse event: Bronchitis
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 112 at risk

Adverse event: Haemoptysis
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 6 affected / 112 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 5 affected / 112 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 14 affected / 112 at risk

Adverse event: Upper respiratory tract infection
Serious: no
Organ System: Infections and infestations
Frequency: 7 affected / 112 at risk
Study: NCT01743040

Adverse event: Death
Serious: yes
Organ System: Congenital, familial and genetic disorders
Notes: Unknown cause of death, records unavailable. Died in sleep.
Frequency: 1 affected / 1014 at risk

Adverse event: Angina unstable
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 1014 at risk

Adverse event: Laryngoscopy
Serious: yes
Organ System: Surgical and medical procedures
Notes: History of vocal paralysis from stroke.
Frequency: 1 affected / 1014 at risk

Adverse event: Knee arthroplasty
Serious: yes
Organ System: Surgical and medical procedures
Notes: Right total knee replacement
Frequency: 1 affected / 1014 at risk

Adverse event: Pulmonary embolism
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 1014 at risk

Adverse event: Calcaneal Fractures
Serious: yes
Organ System: Injury, poisoning and procedural complications
Notes: Injury from a fall.
Frequency: 1 affected / 1014 at risk

Adverse event: Acute myocardial infarction
Serious: yes
Organ System: Cardiac disorders
Notes: Non-ST-Elevation Myocardial Infarction (NSTEMI)
Frequency: 1 affected / 1014 at risk

Adverse event: Abdominal pain upper
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 1014 at risk

Adverse event: CCTA-IV contrast infiltration
Serious: no
Organ System: Surgical and medical procedures
Notes: Coronary Computed Tomography Angiography-Intravenous (CCTA-IV) contrast infiltration
Frequency: 5 affected / 1014 at risk

Adverse event: CCTA-respiratory
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Wheezing/coughing after taking oral \& iv metoprolol. Related to history of seasonal allergies and use of metoprolol.
Frequency: 1 affected / 1014 at risk

Adverse event: CCTA-rash/hives
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Allergic reaction to contrast dye.
Frequency: 2 affected / 1014 at risk

Adverse event: CCTA-symptomatic bradycardia
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 1014 at risk

Adverse event: Pleurisy
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 1014 at risk
Study: NCT01743729

Adverse event: Vertigo
Serious: yes
Organ System: Ear and labyrinth disorders
Frequency: 1 affected / 359 at risk

Adverse event: Thyrotoxic crisis
Serious: yes
Organ System: Endocrine disorders
Frequency: 1 affected / 359 at risk

Adverse event: Renal cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 359 at risk

Adverse event: Visual acuity reduced
Serious: no
Organ System: Eye disorders
Frequency: 18 affected / 359 at risk

Adverse event: Instillation site irritation
Serious: no
Organ System: General disorders
Frequency: 28 affected / 359 at risk

Adverse event: Instillation site reaction
Serious: no
Organ System: General disorders
Frequency: 25 affected / 359 at risk

Adverse event: Dysgeusia
Serious: no
Organ System: Nervous system disorders
Frequency: 58 affected / 359 at risk

Adverse event: Colitis ischaemic
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 359 at risk

Adverse event: Osteoarthritis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 359 at risk

Adverse event: Bladder cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 359 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 359 at risk

Adverse event: Visual acuity reduced
Serious: no
Organ System: Eye disorders
Frequency: 23 affected / 359 at risk

Adverse event: Instillation site irritation
Serious: no
Organ System: General disorders
Frequency: 5 affected / 359 at risk

Adverse event: Instillation site reaction
Serious: no
Organ System: General disorders
Frequency: 4 affected / 359 at risk

Adverse event: Dysgeusia
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 359 at risk