Study: NCT02271230

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 341 affected / 12927 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Endocrine disorders
Frequency: 147 affected / 12927 at risk

Adverse event: Invasive cancer of any type
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 793 affected / 12927 at risk

Adverse event: Death from cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 154 affected / 12927 at risk

Adverse event: Breast cancer in women
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 124 affected / 12927 at risk

Adverse event: Prostate cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 192 affected / 12927 at risk

Adverse event: Colorectal cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 51 affected / 12927 at risk

Adverse event: Major cardiovascular events
Serious: yes
Organ System: Vascular disorders
Notes: Composite of myocardial infarction, stroke, and cardiovascular death
Frequency: 396 affected / 12927 at risk

Adverse event: Myocardial infarction
Serious: yes
Organ System: Vascular disorders
Frequency: 169 affected / 12927 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Vascular disorders
Frequency: 141 affected / 12927 at risk

Adverse event: Death from cardiovascular causes
Serious: yes
Organ System: Vascular disorders
Frequency: 152 affected / 12927 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 3434 affected / 12927 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 466 affected / 12927 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 911 affected / 12927 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Notes: hyperparathyroidism or hypoparathyroidism
Frequency: 50 affected / 12927 at risk

Adverse event: Stomach upset or pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4860 affected / 12927 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3519 affected / 12927 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5133 affected / 12927 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5511 affected / 12927 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2168 affected / 12927 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 2195 affected / 12927 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 477 affected / 12927 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 85 affected / 12927 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 3268 affected / 12927 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 403 affected / 12944 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Endocrine disorders
Frequency: 143 affected / 12944 at risk

Adverse event: Invasive cancer of any type
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 824 affected / 12944 at risk

Adverse event: Death from cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 187 affected / 12944 at risk

Adverse event: Breast cancer in women
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 122 affected / 12944 at risk

Adverse event: Prostate cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 219 affected / 12944 at risk

Adverse event: Colorectal cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 47 affected / 12944 at risk

Adverse event: Major cardiovascular events
Serious: yes
Organ System: Vascular disorders
Notes: Composite of myocardial infarction, stroke, and cardiovascular death
Frequency: 409 affected / 12944 at risk

Adverse event: Myocardial infarction
Serious: yes
Organ System: Vascular disorders
Frequency: 176 affected / 12944 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Vascular disorders
Frequency: 149 affected / 12944 at risk

Adverse event: Death from cardiovascular causes
Serious: yes
Organ System: Vascular disorders
Frequency: 138 affected / 12944 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 3408 affected / 12944 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 490 affected / 12944 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 882 affected / 12944 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Notes: hyperparathyroidism or hypoparathyroidism
Frequency: 62 affected / 12944 at risk

Adverse event: Stomach upset or pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4870 affected / 12944 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3589 affected / 12944 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5162 affected / 12944 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5668 affected / 12944 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2207 affected / 12944 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 2290 affected / 12944 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 426 affected / 12944 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 88 affected / 12944 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 3430 affected / 12944 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 370 affected / 12933 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Endocrine disorders
Frequency: 151 affected / 12933 at risk

Adverse event: Invasive cancer of any type
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 820 affected / 12933 at risk

Adverse event: Death from cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 168 affected / 12933 at risk

Adverse event: Breast cancer in women
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 117 affected / 12933 at risk

Adverse event: Prostate cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 219 affected / 12933 at risk

Adverse event: Colorectal cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 54 affected / 12933 at risk

Adverse event: Major cardiovascular events
Serious: yes
Organ System: Vascular disorders
Notes: Composite of myocardial infarction, stroke, and cardiovascular death
Frequency: 386 affected / 12933 at risk

Adverse event: Myocardial infarction
Serious: yes
Organ System: Vascular disorders
Frequency: 145 affected / 12933 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Vascular disorders
Frequency: 148 affected / 12933 at risk

Adverse event: Death from cardiovascular causes
Serious: yes
Organ System: Vascular disorders
Frequency: 142 affected / 12933 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 3443 affected / 12933 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 465 affected / 12933 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 919 affected / 12933 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Notes: hyperparathyroidism or hypoparathyroidism
Frequency: 52 affected / 12933 at risk

Adverse event: Stomach upset or pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4887 affected / 12933 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3558 affected / 12933 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5184 affected / 12933 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5599 affected / 12933 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2217 affected / 12933 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 2240 affected / 12933 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 430 affected / 12933 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 85 affected / 12933 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 3331 affected / 12933 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 374 affected / 12938 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Endocrine disorders
Frequency: 139 affected / 12938 at risk

Adverse event: Invasive cancer of any type
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 797 affected / 12938 at risk

Adverse event: Death from cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 173 affected / 12938 at risk

Adverse event: Breast cancer in women
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 129 affected / 12938 at risk

Adverse event: Prostate cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 192 affected / 12938 at risk

Adverse event: Colorectal cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 44 affected / 12938 at risk

Adverse event: Major cardiovascular events
Serious: yes
Organ System: Vascular disorders
Notes: Composite of myocardial infarction, stroke, and cardiovascular death
Frequency: 419 affected / 12938 at risk

Adverse event: Myocardial infarction
Serious: yes
Organ System: Vascular disorders
Frequency: 200 affected / 12938 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Vascular disorders
Frequency: 142 affected / 12938 at risk

Adverse event: Death from cardiovascular causes
Serious: yes
Organ System: Vascular disorders
Frequency: 148 affected / 12938 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 3399 affected / 12938 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 491 affected / 12938 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 874 affected / 12938 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Notes: hyperparathyroidism or hypoparathyroidism
Frequency: 60 affected / 12938 at risk

Adverse event: Stomach upset or pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4843 affected / 12938 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3550 affected / 12938 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5111 affected / 12938 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 5580 affected / 12938 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2158 affected / 12938 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 2245 affected / 12938 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 473 affected / 12938 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 88 affected / 12938 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 3367 affected / 12938 at risk