Study: NCT02704156

Adverse event: Grade 3 vomitting
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 85 at risk

Adverse event: Grade 3 and 4 increased ALT or AST
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 6 affected / 85 at risk

Adverse event: Grade 3 and 4 neutropenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 9 affected / 85 at risk

Adverse event: Grade 3 thrombocytopenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 4 affected / 85 at risk

Adverse event: Grade 1-2 Nausea and vomitting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 17 affected / 85 at risk

Adverse event: Grade 1-2 diarrhea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 16 affected / 85 at risk

Adverse event: Grade 1-2 increased ALT or AST
Serious: no
Organ System: Hepatobiliary disorders
Frequency: 12 affected / 85 at risk

Adverse event: Grade 1-2 rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 85 at risk

Adverse event: Grade 1-2 neutropenia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 21 affected / 85 at risk

Adverse event: Grade 1-2 thrombocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 15 affected / 85 at risk

Adverse event: Grade 1-2 proteinuria
Serious: no
Organ System: Renal and urinary disorders
Frequency: 2 affected / 85 at risk

Adverse event: Grade 3 pyrexia
Serious: yes
Organ System: General disorders
Frequency: 2 affected / 85 at risk

Adverse event: Grade 3 vomitting
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 85 at risk

Adverse event: Grade 3 and 4 increased ALT or AST
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 10 affected / 85 at risk

Adverse event: Grade 3 stomatitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 85 at risk

Adverse event: Grade 3 rash
Serious: yes
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 85 at risk

Adverse event: Grade 3 and 4 neutropenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 85 at risk

Adverse event: Grade 3 thrombocytopenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 85 at risk

Adverse event: Grade 3 increased blood bilirubin
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 4 affected / 85 at risk

Adverse event: Grade 3 hypokalemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 85 at risk

Adverse event: Grade 3 hyponatremia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 3 affected / 85 at risk

Adverse event: Grade 3 pneumonia
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 85 at risk

Adverse event: Grade 3 hypertension
Serious: yes
Organ System: Cardiac disorders
Frequency: 2 affected / 85 at risk

Adverse event: Grade 1-2 Nausea and vomitting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 11 affected / 85 at risk

Adverse event: Grade 1-2 diarrhea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 18 affected / 85 at risk

Adverse event: Grade 1-2 increased ALT or AST
Serious: no
Organ System: Hepatobiliary disorders
Frequency: 16 affected / 85 at risk

Adverse event: Grade 1-2 stomatitis
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 8 affected / 85 at risk

Adverse event: Grade 1-2 rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 14 affected / 85 at risk

Adverse event: Grade 1-2 neutropenia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 6 affected / 85 at risk

Adverse event: Grade 1-2 thrombocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 7 affected / 85 at risk

Adverse event: Grade 1-2 proteinuria
Serious: no
Organ System: Renal and urinary disorders
Frequency: 5 affected / 85 at risk