Study: NCT02250651

Adverse event: Atrial fibrillation
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 176 at risk

Adverse event: Myocardial infarction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 176 at risk

Adverse event: Angina pectoris
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 176 at risk

Adverse event: Angina unstable
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 176 at risk

Adverse event: Coronary artery disease
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 176 at risk

Adverse event: Supraventricular tachycardia
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 176 at risk

Adverse event: Ascites
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 176 at risk

Adverse event: Pancreatitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 176 at risk

Adverse event: Rectal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 176 at risk

Adverse event: Cholangitis acute
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 176 at risk

Adverse event: Sarcoidosis
Serious: yes
Organ System: Immune system disorders
Frequency: 1 affected / 176 at risk

Adverse event: Pneumonia
Serious: yes
Organ System: Infections and infestations
Frequency: 3 affected / 176 at risk

Adverse event: Appendicitis
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 176 at risk

Adverse event: Jaw fracture
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 176 at risk

Adverse event: Procedural pain
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 176 at risk

Adverse event: Diabetes mellitus inadequate control
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 176 at risk

Adverse event: Hypoglycaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 176 at risk

Adverse event: Osteoarthritis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 3 affected / 176 at risk

Adverse event: Rhabdomyolysis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 176 at risk

Adverse event: Prostate cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Notes: Number of participants at risk are male participants as this adverse event is specific to males.
Frequency: 2 affected / 85 at risk

Adverse event: Basal cell carcinoma
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 2 affected / 176 at risk

Adverse event: Breast cancer stage I
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 176 at risk

Adverse event: Hepatocellular carcinoma
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 176 at risk

Adverse event: Metastases to liver
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 176 at risk

Adverse event: Metastases to lung
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 176 at risk

Adverse event: Natural killer-cell leukaemia
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 176 at risk

Adverse event: Squamous cell carcinoma of skin
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 176 at risk

Adverse event: Waldenstrom's macroglobulinaemia
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 176 at risk

Adverse event: Encephalopathy
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 176 at risk

Adverse event: Corneal endothelial cell loss
Serious: yes
Organ System: Eye disorders
Notes: 12 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=9, Bimatoprost SR 10 ug=3).
Frequency: 9 affected / 176 at risk

Adverse event: Corneal oedema
Serious: yes
Organ System: Eye disorders
Notes: 3 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=2, Bimatoprost SR 10 ug=1).
Frequency: 2 affected / 176 at risk

Adverse event: Macular oedema
Serious: yes
Organ System: Eye disorders
Notes: 1 adverse event occurred in the study eye.
Frequency: 1 affected / 176 at risk

Adverse event: Product administered at inappropriate site
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 176 at risk

Adverse event: Pterygium
Serious: yes
Organ System: Eye disorders
Notes: 1 adverse event occurred in the study eye.
Frequency: 1 affected / 176 at risk

Adverse event: VIth nerve paralysis
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 176 at risk

Adverse event: Retinal tear
Serious: yes
Organ System: Eye disorders
Notes: 1 adverse event occurred in the fellow (non-study) eye.
Frequency: 1 affected / 176 at risk

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Notes: 138 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=71, Bimatoprost SR 10 ug=48, and Timolol 0.5%=19); 86 adverse events occurred in the fellow (non-study) eye.
Frequency: 73 affected / 176 at risk

Adverse event: Corneal endothelial cell loss
Serious: no
Organ System: Eye disorders
Notes: 50 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=38, Bimatoprost SR 10 ug=11, and Timolol 0.5%=1); 4 adverse events occurred in the fellow (non-study) eye.
Frequency: 38 affected / 176 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Notes: 40 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=21, Bimatoprost SR 10 ug=11, and Timolol 0.5%=8); 16 adverse events occurred in the fellow (non-study) eye.
Frequency: 23 affected / 176 at risk

Adverse event: Corneal oedema
Serious: no
Organ System: Eye disorders
Notes: 26 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=21, Bimatoprost SR 10 ug=5).
Frequency: 21 affected / 176 at risk

Adverse event: Foreign body sensation in eyes
Serious: no
Organ System: Eye disorders
Notes: 37 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=18, Bimatoprost SR 10 ug=17, and Timolol 0.5%=2); 17 adverse events occurred in the fellow (non-study) eye.
Frequency: 19 affected / 176 at risk

Adverse event: Dry eye
Serious: no
Organ System: Eye disorders
Notes: 33 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=16, Bimatoprost SR 10 ug=10, and Timolol 0.5%=7); 31 adverse events occurred in the fellow (non-study) eye.
Frequency: 18 affected / 176 at risk

Adverse event: Conjunctival haemorrhage
Serious: no
Organ System: Eye disorders
Notes: 42 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=14, Bimatoprost SR 10 ug=16, and Timolol 0.5%=12); 22 adverse events occurred in the fellow (non-study) eye.
Frequency: 17 affected / 176 at risk

Adverse event: Punctate keratitis
Serious: no
Organ System: Eye disorders
Notes: 28 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=13, Bimatoprost SR 10 ug=8, and Timolol 0.5%=7); 26 adverse events occurred in the fellow (non-study) eye.
Frequency: 14 affected / 176 at risk

Adverse event: Photophobia
Serious: no
Organ System: Eye disorders
Notes: 26 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=13, Bimatoprost SR 10 ug=13); 13 adverse events occurred in the fellow (non-study) eye.
Frequency: 13 affected / 176 at risk

Adverse event: Eye irritation
Serious: no
Organ System: Eye disorders
Notes: 28 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=12, Bimatoprost SR 10 ug=9, and Timolol 0.5%=7); 23 adverse events occurred in the fellow (non-study) eye.
Frequency: 13 affected / 176 at risk

Adverse event: Anterior chamber cell
Serious: no
Organ System: Eye disorders
Notes: 19 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=12, Bimatoprost SR 10 ug=6, and Timolol 0.5%=1); 1 adverse event occurred in the fellow (non-study) eye.
Frequency: 13 affected / 176 at risk

Adverse event: Ocular discomfort
Serious: no
Organ System: Eye disorders
Notes: 15 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=11, Bimatoprost SR 10 ug=3, and Timolol 0.5%=1); 4 adverse events occurred in the fellow (non-study) eye.
Frequency: 11 affected / 176 at risk

Adverse event: Iritis
Serious: no
Organ System: Eye disorders
Notes: 17 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=9, Bimatoprost SR 10 ug=8); 1 adverse event occurred in the fellow (non-study) eye.
Frequency: 9 affected / 176 at risk

Adverse event: Lacrimation increased
Serious: no
Organ System: Eye disorders
Notes: 16 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=9, Bimatoprost SR 10 ug=6, and Timolol 0.5%=1); 12 adverse events occurred in the fellow (non-study) eye.
Frequency: 9 affected / 176 at risk

Adverse event: Vision blurred
Serious: no
Organ System: Eye disorders
Notes: 17 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=7, Bimatoprost SR 10 ug=9, and Timolol 0.5%=1); 11 adverse events occurred in the fellow (non-study) eye.
Frequency: 7 affected / 176 at risk

Adverse event: Blepharitis
Serious: no
Organ System: Eye disorders
Notes: 21 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=7, Bimatoprost SR 10 ug=9, and Timolol 0.5%=5); 18 adverse events occurred in the fellow (non-study) eye.
Frequency: 7 affected / 176 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 9 affected / 176 at risk

Adverse event: Intraocular pressure increased
Serious: no
Organ System: Investigations
Frequency: 17 affected / 176 at risk

Adverse event: Atrial fibrillation
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 175 at risk

Adverse event: Sudden hearing loss
Serious: yes
Organ System: Ear and labyrinth disorders
Frequency: 1 affected / 175 at risk

Adverse event: Cholelithiasis
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 175 at risk

Adverse event: Fall
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 2 affected / 175 at risk

Adverse event: Hip fracture
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 175 at risk

Adverse event: Femur fracture
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 175 at risk

Adverse event: Humerus fracture
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 175 at risk

Adverse event: Rib fracture
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 175 at risk

Adverse event: Subdural haematoma
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 175 at risk

Adverse event: Haemarthrosis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 175 at risk

Adverse event: Bronchial carcinoma
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 175 at risk

Adverse event: Oropharyngeal squamous cell carcinoma
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 175 at risk

Adverse event: Transient ischaemic attack
Serious: yes
Organ System: Nervous system disorders
Frequency: 2 affected / 175 at risk

Adverse event: Ischaemic stroke
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 175 at risk

Adverse event: Bipolar disorder
Serious: yes
Organ System: Psychiatric disorders
Frequency: 1 affected / 175 at risk

Adverse event: End stage renal disease
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 175 at risk

Adverse event: Heavy menstrual bleeding
Serious: yes
Organ System: Reproductive system and breast disorders
Notes: Number of participants at risk are female participants as this adverse event is specific to females.
Frequency: 1 affected / 90 at risk

Adverse event: Ovarian cyst
Serious: yes
Organ System: Reproductive system and breast disorders
Notes: Number of participants at risk are female participants as this adverse event is specific to females.
Frequency: 1 affected / 90 at risk

Adverse event: Aortic stenosis
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 175 at risk

Adverse event: Corneal endothelial cell loss
Serious: yes
Organ System: Eye disorders
Notes: 12 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=9, Bimatoprost SR 10 ug=3).
Frequency: 3 affected / 175 at risk

Adverse event: Corneal oedema
Serious: yes
Organ System: Eye disorders
Notes: 3 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=2, Bimatoprost SR 10 ug=1).
Frequency: 1 affected / 175 at risk

Adverse event: Corneal decompensation
Serious: yes
Organ System: Eye disorders
Notes: 1 adverse event occurred in the study eye.
Frequency: 1 affected / 175 at risk

Adverse event: Retinal detachment
Serious: yes
Organ System: Eye disorders
Notes: 1 adverse event occurred in the study eye.
Frequency: 1 affected / 175 at risk

Adverse event: Visual impairment
Serious: yes
Organ System: Eye disorders
Notes: 1 adverse event occurred in the study eye.
Frequency: 1 affected / 175 at risk

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Notes: 138 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=71, Bimatoprost SR 10 ug=48, and Timolol 0.5%=19); 86 adverse events occurred in the fellow (non-study) eye.
Frequency: 48 affected / 175 at risk

Adverse event: Corneal endothelial cell loss
Serious: no
Organ System: Eye disorders
Notes: 50 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=38, Bimatoprost SR 10 ug=11, and Timolol 0.5%=1); 4 adverse events occurred in the fellow (non-study) eye.
Frequency: 12 affected / 175 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Notes: 40 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=21, Bimatoprost SR 10 ug=11, and Timolol 0.5%=8); 16 adverse events occurred in the fellow (non-study) eye.
Frequency: 12 affected / 175 at risk

Adverse event: Corneal oedema
Serious: no
Organ System: Eye disorders
Notes: 26 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=21, Bimatoprost SR 10 ug=5).
Frequency: 5 affected / 175 at risk

Adverse event: Foreign body sensation in eyes
Serious: no
Organ System: Eye disorders
Notes: 37 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=18, Bimatoprost SR 10 ug=17, and Timolol 0.5%=2); 17 adverse events occurred in the fellow (non-study) eye.
Frequency: 18 affected / 175 at risk

Adverse event: Dry eye
Serious: no
Organ System: Eye disorders
Notes: 33 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=16, Bimatoprost SR 10 ug=10, and Timolol 0.5%=7); 31 adverse events occurred in the fellow (non-study) eye.
Frequency: 12 affected / 175 at risk

Adverse event: Conjunctival haemorrhage
Serious: no
Organ System: Eye disorders
Notes: 42 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=14, Bimatoprost SR 10 ug=16, and Timolol 0.5%=12); 22 adverse events occurred in the fellow (non-study) eye.
Frequency: 20 affected / 175 at risk

Adverse event: Punctate keratitis
Serious: no
Organ System: Eye disorders
Notes: 28 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=13, Bimatoprost SR 10 ug=8, and Timolol 0.5%=7); 26 adverse events occurred in the fellow (non-study) eye.
Frequency: 10 affected / 175 at risk

Adverse event: Photophobia
Serious: no
Organ System: Eye disorders
Notes: 26 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=13, Bimatoprost SR 10 ug=13); 13 adverse events occurred in the fellow (non-study) eye.
Frequency: 13 affected / 175 at risk

Adverse event: Eye irritation
Serious: no
Organ System: Eye disorders
Notes: 28 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=12, Bimatoprost SR 10 ug=9, and Timolol 0.5%=7); 23 adverse events occurred in the fellow (non-study) eye.
Frequency: 10 affected / 175 at risk

Adverse event: Anterior chamber cell
Serious: no
Organ System: Eye disorders
Notes: 19 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=12, Bimatoprost SR 10 ug=6, and Timolol 0.5%=1); 1 adverse event occurred in the fellow (non-study) eye.
Frequency: 6 affected / 175 at risk

Adverse event: Ocular discomfort
Serious: no
Organ System: Eye disorders
Notes: 15 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=11, Bimatoprost SR 10 ug=3, and Timolol 0.5%=1); 4 adverse events occurred in the fellow (non-study) eye.
Frequency: 3 affected / 175 at risk

Adverse event: Iritis
Serious: no
Organ System: Eye disorders
Notes: 17 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=9, Bimatoprost SR 10 ug=8); 1 adverse event occurred in the fellow (non-study) eye.
Frequency: 8 affected / 175 at risk

Adverse event: Lacrimation increased
Serious: no
Organ System: Eye disorders
Notes: 16 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=9, Bimatoprost SR 10 ug=6, and Timolol 0.5%=1); 12 adverse events occurred in the fellow (non-study) eye.
Frequency: 7 affected / 175 at risk

Adverse event: Vision blurred
Serious: no
Organ System: Eye disorders
Notes: 17 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=7, Bimatoprost SR 10 ug=9, and Timolol 0.5%=1); 11 adverse events occurred in the fellow (non-study) eye.
Frequency: 11 affected / 175 at risk

Adverse event: Blepharitis
Serious: no
Organ System: Eye disorders
Notes: 21 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=7, Bimatoprost SR 10 ug=9, and Timolol 0.5%=5); 18 adverse events occurred in the fellow (non-study) eye.
Frequency: 10 affected / 175 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 12 affected / 175 at risk

Adverse event: Intraocular pressure increased
Serious: no
Organ System: Investigations
Frequency: 15 affected / 175 at risk

Adverse event: Myocardial infarction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 173 at risk

Adverse event: Cardiac failure congestive
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 173 at risk

Adverse event: Mitral valve incompetence
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 173 at risk

Adverse event: Vomiting
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 173 at risk

Adverse event: Diverticular perforation
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 173 at risk

Adverse event: Nausea
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 173 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 173 at risk

Adverse event: Hip fracture
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 173 at risk

Adverse event: Hyperkalaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 173 at risk

Adverse event: Metabolic acidosis
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 173 at risk

Adverse event: Prostate cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Notes: Number of participants at risk are male participants as this adverse event is specific to males.
Frequency: 1 affected / 88 at risk

Adverse event: Follicular thyroid cancer
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 173 at risk

Adverse event: Small intestine carcinoma metastatic
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 173 at risk

Adverse event: Squamous cell carcinoma
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 173 at risk

Adverse event: Depression
Serious: yes
Organ System: Psychiatric disorders
Frequency: 1 affected / 173 at risk

Adverse event: Schizophrenia
Serious: yes
Organ System: Psychiatric disorders
Frequency: 1 affected / 173 at risk

Adverse event: Acute kidney injury
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 173 at risk

Adverse event: Micturition urgency
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 173 at risk

Adverse event: Nephrolithiasis
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 173 at risk

Adverse event: Penetrating aortic ulcer
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 173 at risk

Adverse event: Peripheral arterial occlusive disease
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 173 at risk

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Notes: 138 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=71, Bimatoprost SR 10 ug=48, and Timolol 0.5%=19); 86 adverse events occurred in the fellow (non-study) eye.
Frequency: 20 affected / 173 at risk

Adverse event: Corneal endothelial cell loss
Serious: no
Organ System: Eye disorders
Notes: 50 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=38, Bimatoprost SR 10 ug=11, and Timolol 0.5%=1); 4 adverse events occurred in the fellow (non-study) eye.
Frequency: 2 affected / 173 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Notes: 40 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=21, Bimatoprost SR 10 ug=11, and Timolol 0.5%=8); 16 adverse events occurred in the fellow (non-study) eye.
Frequency: 9 affected / 173 at risk

Adverse event: Foreign body sensation in eyes
Serious: no
Organ System: Eye disorders
Notes: 37 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=18, Bimatoprost SR 10 ug=17, and Timolol 0.5%=2); 17 adverse events occurred in the fellow (non-study) eye.
Frequency: 2 affected / 173 at risk

Adverse event: Dry eye
Serious: no
Organ System: Eye disorders
Notes: 33 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=16, Bimatoprost SR 10 ug=10, and Timolol 0.5%=7); 31 adverse events occurred in the fellow (non-study) eye.
Frequency: 7 affected / 173 at risk

Adverse event: Conjunctival haemorrhage
Serious: no
Organ System: Eye disorders
Notes: 42 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=14, Bimatoprost SR 10 ug=16, and Timolol 0.5%=12); 22 adverse events occurred in the fellow (non-study) eye.
Frequency: 15 affected / 173 at risk

Adverse event: Punctate keratitis
Serious: no
Organ System: Eye disorders
Notes: 28 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=13, Bimatoprost SR 10 ug=8, and Timolol 0.5%=7); 26 adverse events occurred in the fellow (non-study) eye.
Frequency: 8 affected / 173 at risk

Adverse event: Eye irritation
Serious: no
Organ System: Eye disorders
Notes: 28 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=12, Bimatoprost SR 10 ug=9, and Timolol 0.5%=7); 23 adverse events occurred in the fellow (non-study) eye.
Frequency: 9 affected / 173 at risk

Adverse event: Anterior chamber cell
Serious: no
Organ System: Eye disorders
Notes: 19 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=12, Bimatoprost SR 10 ug=6, and Timolol 0.5%=1); 1 adverse event occurred in the fellow (non-study) eye.
Frequency: 1 affected / 173 at risk

Adverse event: Ocular discomfort
Serious: no
Organ System: Eye disorders
Notes: 15 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=11, Bimatoprost SR 10 ug=3, and Timolol 0.5%=1); 4 adverse events occurred in the fellow (non-study) eye.
Frequency: 1 affected / 173 at risk

Adverse event: Lacrimation increased
Serious: no
Organ System: Eye disorders
Notes: 16 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=9, Bimatoprost SR 10 ug=6, and Timolol 0.5%=1); 12 adverse events occurred in the fellow (non-study) eye.
Frequency: 1 affected / 173 at risk

Adverse event: Vision blurred
Serious: no
Organ System: Eye disorders
Notes: 17 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=7, Bimatoprost SR 10 ug=9, and Timolol 0.5%=1); 11 adverse events occurred in the fellow (non-study) eye.
Frequency: 1 affected / 173 at risk

Adverse event: Blepharitis
Serious: no
Organ System: Eye disorders
Notes: 21 adverse events occurred in the study eye: (Bimatoprost SR 15 ug=7, Bimatoprost SR 10 ug=9, and Timolol 0.5%=5); 18 adverse events occurred in the fellow (non-study) eye.
Frequency: 5 affected / 173 at risk

Adverse event: Nasopharyngitis
Serious: no
Organ System: Infections and infestations
Frequency: 14 affected / 173 at risk

Adverse event: Intraocular pressure increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 173 at risk