TrialPanorama/TrialPanorama-database huggingface dataset:
Study: NCT00005669

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 28 affected / 53 at risk

Adverse event: Liquid Stools
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 22 affected / 53 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 22 affected / 53 at risk

Adverse event: Abdominal distension
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 13 affected / 53 at risk

Adverse event: Increased Bowel Movements
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 22 affected / 53 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 20 affected / 53 at risk

Adverse event: Decreased Happiness
Serious: no
Organ System: General disorders
Frequency: 14 affected / 53 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 17 affected / 47 at risk

Adverse event: Liquid Stools
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 8 affected / 47 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 10 affected / 47 at risk

Adverse event: Abdominal distension
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 6 affected / 47 at risk

Adverse event: Increased Bowel Movements
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 11 affected / 47 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 7 affected / 47 at risk

Adverse event: Decreased Happiness
Serious: no
Organ System: General disorders
Frequency: 6 affected / 47 at risk
Study: NCT00005803

Adverse event: Bowel perforation and sepsis
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 76 at risk

Adverse event: Sepsis with respiratory failure and mental status changes
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 76 at risk

Adverse event: Tachycardia, intubation, sepsis and pulmonary embolus
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 76 at risk

Adverse event: Death due to multiple pulmonary infections
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 76 at risk

Adverse event: Pulmonary failure requiring intubation
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 2 affected / 76 at risk

Adverse event: Death due to infection with pericardial and epicardial involvement
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 76 at risk

Adverse event: Respiratory arrest due to disease progression
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 76 at risk

Adverse event: Hypoxia due to organizing pneumonitis
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 76 at risk

Adverse event: Hypoxemia during PBSC infusion
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 76 at risk

Adverse event: Pulmonary embolism
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 76 at risk

Adverse event: Intra-abdominal hemorrhage when undergoing VATS procedure
Serious: yes
Organ System: Surgical and medical procedures
Frequency: 1 affected / 76 at risk

Adverse event: Seizure
Serious: yes
Organ System: General disorders
Notes: no etilogy for the seizures identified
Frequency: 1 affected / 76 at risk

Adverse event: Hyperbilirubinaemia
Serious: no
Organ System: Hepatobiliary disorders
Frequency: 11 affected / 76 at risk

Adverse event: Increased Creatinine
Serious: no
Organ System: Renal and urinary disorders
Frequency: 16 affected / 76 at risk

Adverse event: Hypoxia
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 8 affected / 76 at risk

Adverse event: Pulmonary alveolar haemorrhage
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 6 affected / 76 at risk
Study: NCT00005901

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 1 affected / 15 at risk
Study: NCT00005906

Adverse event: Gastrointestinal disorders
Serious: yes
Organ System: Hepatobiliary disorders
Notes: On September 2000 the patient referred right upper quadrant abdominal pain. An abdominal ultrasound showed gallbladder sludge. Octreotide was discontinued. In December, an ultrasound showed gallstones. In February 2001 she had a cholecystectomy.
Frequency: 1 affected / 4 at risk

Adverse event: Liver function abnormalities
Serious: no
Organ System: Gastrointestinal disorders
Notes: Mild elevation of liver function tests.
Frequency: 1 affected / 4 at risk
Study: NCT00005937

Adverse event: Death
Serious: yes
Organ System: Infections and infestations
Frequency: 7 affected / 42 at risk

Adverse event: Hospitalization pulmonary related
Serious: yes
Organ System: General disorders
Frequency: 2 affected / 42 at risk

Adverse event: Hospitalization cardiac related
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 42 at risk

Adverse event: Hospitalisation
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 42 at risk

Adverse event: Toxicity with disease progression
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 42 at risk
Study: NCT00006046

Adverse event: Actinomycosis
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 7 at risk

Adverse event: Back pain
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 7 at risk

Adverse event: Neutropenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 7 at risk

Adverse event: Rectal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 7 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 7 at risk

Adverse event: Chills
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 7 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 7 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 7 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 7 at risk

Adverse event: Pyrexia
Serious: no
Organ System: General disorders
Frequency: 1 affected / 7 at risk

Adverse event: Tumour haemorrhage
Serious: no
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 7 at risk

Adverse event: Viral infection
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 7 at risk
Study: NCT00006101

Adverse event: Prostate Cancer Diagnosis
Serious: yes
Organ System: Reproductive system and breast disorders
Notes: Diagnosed at 6 or 12 month biopsy
Frequency: 3 affected / 38 at risk

Adverse event: Knee arthroplasty
Serious: yes
Organ System: Surgical and medical procedures
Notes: Hospitalized for full knee replacement
Frequency: 1 affected / 38 at risk

Adverse event: Muscular skeletal complaints
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Complaints include disk disease, tendonitis, etc.
Frequency: 7 affected / 38 at risk

Adverse event: Hearing Related Complaints
Serious: no
Organ System: Nervous system disorders
Notes: Include tinnitus, vertigo, and hearing changes
Frequency: 5 affected / 38 at risk

Adverse event: Sexual Difficulties
Serious: no
Organ System: Reproductive system and breast disorders
Frequency: 3 affected / 38 at risk

Adverse event: Gastrointestinal Side Effects
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 38 at risk

Adverse event: Flu or cold symptoms
Serious: no
Organ System: General disorders
Frequency: 1 affected / 38 at risk

Adverse event: Prostate Cancer Diagnosis
Serious: yes
Organ System: Reproductive system and breast disorders
Notes: Diagnosed at 6 or 12 month biopsy
Frequency: 1 affected / 38 at risk

Adverse event: Muscular skeletal complaints
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Complaints include disk disease, tendonitis, etc.
Frequency: 2 affected / 38 at risk

Adverse event: Hearing Related Complaints
Serious: no
Organ System: Nervous system disorders
Notes: Include tinnitus, vertigo, and hearing changes
Frequency: 6 affected / 38 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 38 at risk

Adverse event: Chest pain
Serious: no
Organ System: General disorders
Frequency: 1 affected / 38 at risk

Adverse event: Vomiting
Serious: no
Organ System: General disorders
Frequency: 1 affected / 38 at risk

Adverse event: Sexual Difficulties
Serious: no
Organ System: Reproductive system and breast disorders
Frequency: 2 affected / 38 at risk

Adverse event: Gastrointestinal Side Effects
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 38 at risk

Adverse event: Flu or cold symptoms
Serious: no
Organ System: General disorders
Frequency: 1 affected / 38 at risk
Study: NCT00006178

Adverse event: Transplant rejection
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 3 affected / 12 at risk

Adverse event: varicella zoster reactivation
Serious: no
Organ System: General disorders
Frequency: 1 affected / 12 at risk

Adverse event: bacterial urnary tract infection
Serious: no
Organ System: Renal and urinary disorders
Notes: bacterial urinary tract infection with infected polycystic kidneys and a pretransplantation neurogenic bladder
Frequency: 2 affected / 12 at risk

Adverse event: diabetic foot cellulitis
Serious: no
Organ System: Metabolism and nutrition disorders
Notes: diabetic foot cellulitis 15 months after transplantation
Frequency: 1 affected / 12 at risk

Adverse event: Hernia
Serious: no
Organ System: General disorders
Frequency: 2 affected / 12 at risk

Adverse event: lymphocoele
Serious: no
Organ System: Immune system disorders
Notes: lymphocoele needing transperitoneal drainage
Frequency: 1 affected / 12 at risk

Adverse event: postpolio motor neuropathy
Serious: no
Organ System: General disorders
Notes: postpolio motor neuropathy 1 year after transplantation responsive to intravenous immunoglobulin
Frequency: 1 affected / 12 at risk

Adverse event: Sirolimus-side-effect (diarrhoea)
Serious: no
Organ System: General disorders
Frequency: 3 affected / 12 at risk

Adverse event: Sirolimus-side-effect (mouth ulcers)
Serious: no
Organ System: General disorders
Frequency: 8 affected / 12 at risk

Adverse event: Sirolimus-side-effect (arthralgias)
Serious: no
Organ System: General disorders
Frequency: 2 affected / 12 at risk

Adverse event: Sirolimus-side-effect (hyperlipidaemia)
Serious: no
Organ System: General disorders
Frequency: 10 affected / 12 at risk
Study: NCT00006227

Adverse event: Neutrophil count decreased
Serious: yes
Organ System: Investigations
Frequency: 1 affected / 31 at risk

Adverse event: White blood cell count decreased
Serious: yes
Organ System: Investigations
Frequency: 1 affected / 31 at risk

Adverse event: Muscular weakness
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 31 at risk

Adverse event: Hyperglycaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 31 at risk

Adverse event: Injection site reaction
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 31 at risk

Adverse event: Febrile neutropenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 31 at risk

Adverse event: Leukopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 19 affected / 31 at risk

Adverse event: Neutropenia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 21 affected / 31 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 20 affected / 31 at risk

Adverse event: Thrombocytopenia
Serious: no
Organ System: Investigations
Frequency: 6 affected / 31 at risk

Adverse event: Hypersensitivity
Serious: no
Organ System: Immune system disorders
Frequency: 4 affected / 31 at risk

Adverse event: Cardiovascular
Serious: no
Organ System: Cardiac disorders
Frequency: 4 affected / 31 at risk

Adverse event: Constitutional
Serious: no
Organ System: General disorders
Frequency: 18 affected / 31 at risk

Adverse event: Dermatologic
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 22 affected / 31 at risk

Adverse event: Gastrointestinal
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 18 affected / 31 at risk

Adverse event: Genitourinary
Serious: no
Organ System: Renal and urinary disorders
Frequency: 4 affected / 31 at risk

Adverse event: Hepatic
Serious: no
Organ System: Hepatobiliary disorders
Frequency: 5 affected / 31 at risk

Adverse event: Infection / fever
Serious: no
Organ System: Infections and infestations
Frequency: 4 affected / 31 at risk

Adverse event: Neurologic
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 21 affected / 31 at risk

Adverse event: Metabolic
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 6 affected / 31 at risk

Adverse event: Musculoskeletal
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 6 affected / 31 at risk

Adverse event: Ocular
Serious: no
Organ System: Eye disorders
Frequency: 6 affected / 31 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Frequency: 22 affected / 31 at risk

Adverse event: Pulmonary
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 3 affected / 31 at risk
Study: NCT00006244

Adverse event: Delayed ANC Engraftment
Serious: yes
Organ System: Blood and lymphatic system disorders
Notes: Transplant related
Frequency: 1 affected / 36 at risk

Adverse event: Febrile neutropenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Notes: Transplant related
Frequency: 3 affected / 36 at risk

Adverse event: Fever and GI
Serious: yes
Organ System: General disorders
Notes: Transplant related
Frequency: 1 affected / 36 at risk

Adverse event: Nausea
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Transplant related One patient also had diarrhea
Frequency: 2 affected / 36 at risk

Adverse event: cardiac event
Serious: yes
Organ System: Cardiac disorders
Notes: one patient transplant related one patient interferon related
Frequency: 2 affected / 36 at risk

Adverse event: sarcoidosis/failure to thrive
Serious: yes
Organ System: Immune system disorders
Notes: Interferon related
Frequency: 1 affected / 36 at risk

Adverse event: Hypotension
Serious: yes
Organ System: Cardiac disorders
Notes: Transplant related
Frequency: 1 affected / 36 at risk

Adverse event: Mucosal inflammation
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Transplant related
Frequency: 1 affected / 36 at risk

Adverse event: Colitis
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Transplant related
Frequency: 1 affected / 36 at risk

Adverse event: Pyrexia
Serious: yes
Organ System: Infections and infestations
Notes: Transplant related
Frequency: 1 affected / 36 at risk
Study: NCT00006289

Adverse event: worsening of pain
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 11 at risk
Study: NCT00007475

Adverse event: Rejection of Kidney Graft
Serious: yes
Organ System: Immune system disorders
Notes: Determined after 1 week of cyclophosphamide treatment
Frequency: 1 affected / 12 at risk

Adverse event: Cystitis haemorrhagic
Serious: yes
Organ System: Infections and infestations
Notes: BK viral infection confirmed by high urine BK count per mil 14 weeks after cyclophosphamide initiation; managed by NIH urology team
Frequency: 1 affected / 12 at risk

Adverse event: Adenocarcinoma of the Prostate Gland
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Notes: diagnosed at a point six weeks into treatment by cyclophosphamide
Frequency: 1 affected / 12 at risk

Adverse event: Neutropenia
Serious: yes
Organ System: Blood and lymphatic system disorders
Notes: As defined in Protocol for Patient group 4 (Recurrent FSGS with functioning allograft), having a nadir ANC \<500 cells/µl during cyclophosphamide treatment is a serious AE
Frequency: 1 affected / 12 at risk
Study: NCT00007644

Adverse event: Death
Serious: yes
Organ System: General disorders
Frequency: 171 affected / 364 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Frequency: 183 affected / 367 at risk
Study: NCT00010803

Adverse event: Death
Serious: yes
Organ System: General disorders
Frequency: 197 affected / 1545 at risk

Adverse event: Haemorrhage
Serious: yes
Organ System: General disorders
Notes: Gastrointestinal and all other
Frequency: 138 affected / 1545 at risk

Adverse event: Coronary Heart Disease Total
Serious: yes
Organ System: Vascular disorders
Notes: Myocardial infarction, angina, angioplasty, coronary artery bypass graft, coronary heart disease death
Frequency: 211 affected / 1545 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Vascular disorders
Notes: Ischemic, hemorrhagic and unknown
Frequency: 80 affected / 1545 at risk

Adverse event: All other SAEs
Serious: yes
Organ System: General disorders
Frequency: 374 affected / 1545 at risk

Adverse event: All adverse events
Serious: no
Organ System: General disorders
Notes: There were no statistically significant differences.
Frequency: 1504 affected / 1545 at risk

Adverse event: Self-reported non-hospitalized symptom collected every 6 months
Serious: no
Organ System: General disorders
Frequency: 1504 affected / 1545 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Frequency: 188 affected / 1524 at risk

Adverse event: Haemorrhage
Serious: yes
Organ System: General disorders
Notes: Gastrointestinal and all other
Frequency: 140 affected / 1524 at risk

Adverse event: Coronary Heart Disease Total
Serious: yes
Organ System: Vascular disorders
Notes: Myocardial infarction, angina, angioplasty, coronary artery bypass graft, coronary heart disease death
Frequency: 204 affected / 1524 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Vascular disorders
Notes: Ischemic, hemorrhagic and unknown
Frequency: 71 affected / 1524 at risk

Adverse event: All other SAEs
Serious: yes
Organ System: General disorders
Frequency: 358 affected / 1524 at risk

Adverse event: All adverse events
Serious: no
Organ System: General disorders
Notes: There were no statistically significant differences.
Frequency: 1469 affected / 1524 at risk

Adverse event: Self-reported non-hospitalized symptom collected every 6 months
Serious: no
Organ System: General disorders
Frequency: 1469 affected / 1524 at risk
Study: NCT00015457

Adverse event: hypereosinophila
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 16 at risk

Adverse event: Swelling
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: ankle edema
Frequency: 1 affected / 16 at risk

Adverse event: Dysphagia
Serious: no
Organ System: General disorders
Frequency: 1 affected / 16 at risk

Adverse event: Swelling
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: ankle edema
Frequency: 1 affected / 16 at risk
Study: NCT00015847

Adverse event: Fatigue
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 25 at risk

Adverse event: Bone pain
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 25 at risk

Adverse event: Diarrhoea
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 25 at risk

Adverse event: Elevated Aspartate Aminotransferase (AST) and Alanine Aminotransferase (ALT)
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 3 affected / 25 at risk

Adverse event: Infection
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 25 at risk

Adverse event: Rash
Serious: yes
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 25 at risk

Adverse event: Chills
Serious: no
Organ System: General disorders
Frequency: 2 affected / 25 at risk

Adverse event: Myalgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 3 affected / 25 at risk

Adverse event: Muscle spasms
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 25 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 2 affected / 25 at risk

Adverse event: Headache
Serious: no
Organ System: General disorders
Frequency: 2 affected / 25 at risk

Adverse event: Gout
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 25 at risk

Adverse event: Pruritus
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 25 at risk
Study: NCT00016354

Adverse event: Febrile neutropenia
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 19 at risk

Adverse event: Anemia (Hemoglobin)
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 3 affected / 19 at risk

Adverse event: Thrombocytopenia (Platelets)
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 19 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Frequency: 3 affected / 19 at risk

Adverse event: Headache
Serious: no
Organ System: General disorders
Frequency: 2 affected / 19 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 19 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 19 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 19 at risk

Adverse event: Alopecia
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 19 at risk

Adverse event: Rhinitis
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 19 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 19 at risk

Adverse event: Myalgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 19 at risk

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 19 at risk

Adverse event: Syncope
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 19 at risk