Study: NCT00545077

Adverse event: Abscess right breast
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 184 at risk

Adverse event: Erysipela arm
Serious: yes
Organ System: Infections and infestations
Frequency: 2 affected / 184 at risk

Adverse event: Cerebellum infarction
Serious: yes
Organ System: Nervous system disorders
Frequency: 10 affected / 184 at risk

Adverse event: Syncope
Serious: yes
Organ System: Nervous system disorders
Frequency: 10 affected / 184 at risk

Adverse event: Thrombosis lower leg left
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 184 at risk

Adverse event: Pneumonia aspiration
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 184 at risk

Adverse event: Acute respiratory failure
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 184 at risk

Adverse event: Dyspnoea
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 2 affected / 184 at risk

Adverse event: Pleural effusion
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 2 affected / 184 at risk

Adverse event: Pulmonary embolism
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 184 at risk

Adverse event: Colitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 184 at risk

Adverse event: Inguinal hernia surgery
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 184 at risk

Adverse event: Mucosal inflammation
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 184 at risk

Adverse event: Biliary colic
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 184 at risk

Adverse event: Jaw osteonecrosis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 184 at risk

Adverse event: Nephritis
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 184 at risk

Adverse event: Urinary obstruction
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 184 at risk

Adverse event: Benzodiapezine intoxication
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 184 at risk

Adverse event: Rigth iliac fracture
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 184 at risk

Adverse event: Pain in back
Serious: yes
Organ System: Surgical and medical procedures
Frequency: 1 affected / 184 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 1-4
Frequency: 178 affected / 184 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3-4
Frequency: 1 affected / 184 at risk

Adverse event: Lymphopenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 33 affected / 184 at risk

Adverse event: Lymphopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3-4
Frequency: 5 affected / 184 at risk

Adverse event: Leukopenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 22 affected / 184 at risk

Adverse event: Neutropenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 11 affected / 184 at risk

Adverse event: Thrombocytopenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 16 affected / 184 at risk

Adverse event: Thrombocytopenia
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 5 affected / 184 at risk

Adverse event: Blood alkaline phosphatase
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 22 affected / 184 at risk

Adverse event: Elevated bilirubin
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 8 affected / 184 at risk

Adverse event: Elevated bilirubin
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 1 affected / 184 at risk

Adverse event: Blood creatinine
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 17 affected / 184 at risk

Adverse event: Blood creatinine
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 1 affected / 184 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 1-4
Frequency: 9 affected / 184 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 3-4
Frequency: 1 affected / 184 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 52 affected / 184 at risk

Adverse event: Fever without neutropenia
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 6 affected / 184 at risk

Adverse event: Haemorrhage
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 3 affected / 184 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Notes: Grade 1-4
Frequency: 31 affected / 184 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Notes: Grade 3-4
Frequency: 5 affected / 184 at risk

Adverse event: Elevated liver enzyme (ALT and/or AST)
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 71 affected / 184 at risk

Adverse event: Elevated liver enzyme (ALT and/or AST)
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 1 affected / 184 at risk

Adverse event: Mucositis/stomatitis
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Grade 1-4
Frequency: 5 affected / 184 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 1-4
Frequency: 20 affected / 184 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 90 affected / 184 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Notes: Grade 3-4
Frequency: 4 affected / 184 at risk

Adverse event: Proteinuria
Serious: no
Organ System: Renal and urinary disorders
Notes: Grade 1-4
Frequency: 5 affected / 184 at risk

Adverse event: Thromboembolic events
Serious: no
Organ System: Vascular disorders
Notes: Grade 1-4
Frequency: 1 affected / 184 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 1-4
Frequency: 7 affected / 184 at risk

Adverse event: Appendicitis
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 190 at risk

Adverse event: Infection
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 190 at risk

Adverse event: Neoplasm
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 190 at risk

Adverse event: Promyelocytic leukemia
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 190 at risk

Adverse event: Lymphangitis
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 190 at risk

Adverse event: Hyperkalaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 190 at risk

Adverse event: Depression
Serious: yes
Organ System: Psychiatric disorders
Frequency: 1 affected / 190 at risk

Adverse event: Cerebellum infarction
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 190 at risk

Adverse event: Cerebrovascular ischemia
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 190 at risk

Adverse event: Headache
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 190 at risk

Adverse event: Hemi-hyperesthesia right
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 190 at risk

Adverse event: Ischemic insult
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 190 at risk

Adverse event: Syncope
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 190 at risk

Adverse event: Angina pectoris
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 190 at risk

Adverse event: Cardiac infarction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 190 at risk

Adverse event: Cardiac failure
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 190 at risk

Adverse event: Infarction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 190 at risk

Adverse event: Hypertension
Serious: yes
Organ System: Vascular disorders
Frequency: 6 affected / 190 at risk

Adverse event: Epistaxis
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Pneumonia
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Pulmonary embolism
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 5 affected / 190 at risk

Adverse event: Pancreatitis acute
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Anal fistula
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Diarrhoea
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 190 at risk

Adverse event: Diverticulitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Haemorrhoids
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Intestinal perforation
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Pancreatitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Parodontitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Subileus
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 190 at risk

Adverse event: Vomiting
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 190 at risk

Adverse event: Cholecystis
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 190 at risk

Adverse event: Cholelitiasis
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 190 at risk

Adverse event: Descompensated liver disease
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 190 at risk

Adverse event: Liver disease
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 190 at risk

Adverse event: Osteonecrosis of jaw
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 190 at risk

Adverse event: Jaw osteonecrosis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 190 at risk

Adverse event: Osteochemonecrosis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 190 at risk

Adverse event: Pain left lower extremity
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 190 at risk

Adverse event: Proteinuria
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 4 affected / 190 at risk

Adverse event: Severe renal failure
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 190 at risk

Adverse event: Ulceration of Breast Cancer
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 190 at risk

Adverse event: Hypochondrium pain by increased transaminase values
Serious: yes
Organ System: Investigations
Frequency: 1 affected / 190 at risk

Adverse event: Fracture of Olecranon
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 190 at risk

Adverse event: Overdose Bevacizumab
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 2 affected / 190 at risk

Adverse event: Wound healing complication
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 190 at risk

Adverse event: Sudden death
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 190 at risk

Adverse event: Unknown death
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 190 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 1-4
Frequency: 188 affected / 190 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3-4
Frequency: 1 affected / 190 at risk

Adverse event: Lymphopenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 51 affected / 190 at risk

Adverse event: Lymphopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3-4
Frequency: 6 affected / 190 at risk

Adverse event: Leukopenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 45 affected / 190 at risk

Adverse event: Leukopenia
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 3 affected / 190 at risk

Adverse event: Neutropenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 21 affected / 190 at risk

Adverse event: Neutropenia
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 1 affected / 190 at risk

Adverse event: Thrombocytopenia
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 38 affected / 190 at risk

Adverse event: Thrombocytopenia
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 4 affected / 190 at risk

Adverse event: Blood alkaline phosphatase
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 45 affected / 190 at risk

Adverse event: Blood alkaline phosphatase
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 3 affected / 190 at risk

Adverse event: Elevated bilirubin
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 21 affected / 190 at risk

Adverse event: Elevated bilirubin
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 3 affected / 190 at risk

Adverse event: Blood creatinine
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 36 affected / 190 at risk

Adverse event: Blood creatinine
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 2 affected / 190 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 1-4
Frequency: 27 affected / 190 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 3-4
Frequency: 1 affected / 190 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 101 affected / 190 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Notes: Grade 3-4
Frequency: 4 affected / 190 at risk

Adverse event: Fever without neutropenia
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 17 affected / 190 at risk

Adverse event: Fever without neutropenia
Serious: no
Organ System: General disorders
Notes: Grade 3-4
Frequency: 1 affected / 190 at risk

Adverse event: Haemorrhage
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 36 affected / 190 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Notes: Grade 1-4
Frequency: 116 affected / 190 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Notes: Grade 3-4
Frequency: 29 affected / 190 at risk

Adverse event: Liver dysfunction
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 1-4
Frequency: 7 affected / 190 at risk

Adverse event: Liver dysfunction
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 3-4
Frequency: 3 affected / 190 at risk

Adverse event: Elevated liver enzyme (ALT and/or AST)
Serious: no
Organ System: Investigations
Notes: Grade 1-4
Frequency: 108 affected / 190 at risk

Adverse event: Elevated liver enzyme (ALT and/or AST)
Serious: no
Organ System: Investigations
Notes: Grade 3-4
Frequency: 7 affected / 190 at risk

Adverse event: Mucositis/stomatitis
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Grade 1-4
Frequency: 16 affected / 190 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 1-4
Frequency: 38 affected / 190 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Notes: Grade 1-4
Frequency: 134 affected / 190 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Notes: Grade 3-4
Frequency: 10 affected / 190 at risk

Adverse event: Proteinuria
Serious: no
Organ System: Renal and urinary disorders
Notes: Grade 1-4
Frequency: 64 affected / 190 at risk

Adverse event: Proteinuria
Serious: no
Organ System: Renal and urinary disorders
Notes: Grade 3-4
Frequency: 13 affected / 190 at risk

Adverse event: Thromboembolic events
Serious: no
Organ System: Vascular disorders
Notes: Grade 1-4
Frequency: 4 affected / 190 at risk

Adverse event: Thromboembolic events
Serious: no
Organ System: Vascular disorders
Notes: Grade 3-4
Frequency: 4 affected / 190 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 1-4
Frequency: 23 affected / 190 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 3-4
Frequency: 2 affected / 190 at risk