Study: NCT03267277

Adverse event: Anaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 14 at risk

Adverse event: Catheter site infection
Serious: yes
Organ System: Infections and infestations
Frequency: 2 affected / 14 at risk

Adverse event: Device related infection
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 14 at risk

Adverse event: Foreign body
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 14 at risk

Adverse event: Lymphocyte count decreased
Serious: yes
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Hypokalaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 14 at risk

Adverse event: Hypomagnesaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 14 at risk

Adverse event: Blood calcium decreased
Serious: yes
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Calcium ionised decreased
Serious: yes
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Red blood cell count decreased
Serious: yes
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Abnormal clotting factor
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 4 affected / 14 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 13 affected / 14 at risk

Adverse event: Anisocytosis
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 14 at risk

Adverse event: Urine analysis abnormal
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 12 affected / 14 at risk

Adverse event: Sinus bradycardia
Serious: no
Organ System: Cardiac disorders
Frequency: 4 affected / 14 at risk

Adverse event: Sinus tachycardia
Serious: no
Organ System: Cardiac disorders
Frequency: 9 affected / 14 at risk

Adverse event: Dental caries
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 14 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 7 affected / 14 at risk

Adverse event: Vomiting
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 14 at risk

Adverse event: Hyperthermia
Serious: no
Organ System: General disorders
Frequency: 2 affected / 14 at risk

Adverse event: Coronavirus infection
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 14 at risk

Adverse event: Epstein-Barr virus infection
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 14 at risk

Adverse event: Hepatitis viral
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 14 at risk

Adverse event: Wound infection staphylococcal
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 14 at risk

Adverse event: Activated partial thromboplastin time prolonged
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Activated partial thromboplastin time shortened
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Alanine aminotransferase
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Alanine aminotransferase increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Albumin urine present
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Aldolase increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Anion gap
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Anion gap decreased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Anion gap increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Antinuclear antibody increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Antinuclear antibody positive
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Aspartate aminotransferase
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Aspartate aminotransferase decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Aspartate aminotransferase increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Autoantibody positive
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Basophil count decreased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Basophil count increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Basophil percentage increased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Bilirubin urine present
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood albumin decreased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Basophil percentage decreased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Blood alkaline phosphatase decreased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Blood bicarbonate decreased
Serious: no
Organ System: Investigations
Frequency: 11 affected / 14 at risk

Adverse event: Blood bicarbonate increased
Serious: no
Organ System: Investigations
Frequency: 11 affected / 14 at risk

Adverse event: Blood bilirubin decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood bilirubin increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood chloride decreased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Blood chloride increased
Serious: no
Organ System: Investigations
Frequency: 13 affected / 14 at risk

Adverse event: Blood cholesterol increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Blood creatine phosphokinase decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood creatine phosphokinase increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Blood creatine phosphokinase MB increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Blood creatinine decreased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Blood erythropoietin increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Blood folate increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Blood homocysteine increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood immunoglobulin A increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Blood immunoglobulin E increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Blood immunoglobulin D increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood immunoglobulin G increased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Blood immunoglobulin M decreased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Blood insulin increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Blood iron decreased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Blood iron increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood lactate dehydrogenase increased
Serious: no
Organ System: Investigations
Frequency: 13 affected / 14 at risk

Adverse event: Blood magnesium increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Blood parathyroid hormone
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood parathyroid hormone decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood parathyroid hormone increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Blood phosphorus decreased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Blood phosphorus increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Blood triglycerides increased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Blood urea decreased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Blood urea increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood uric acid increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Brain natriuretic peptide increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: C-reactive protein-high sensitivity increased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Calcium ionised decreased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Calcium ionised increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Carbon dioxide decreased
Serious: no
Organ System: Investigations
Frequency: 11 affected / 14 at risk

Adverse event: Carbon dioxide increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Citric acid urine decreased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Citric acid urine increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Coagulation factor VIII level increased
Serious: no
Organ System: Investigations
Frequency: 12 affected / 14 at risk

Adverse event: Creatinine urine decreased
Serious: no
Organ System: Investigations
Frequency: 13 affected / 14 at risk

Adverse event: Creatinine urine increased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Cystatin C increased
Serious: no
Organ System: Investigations
Frequency: 8 affected / 14 at risk

Adverse event: Drug level above therapeutic
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Electrophoresis protein abnormal
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Eosinophil count decreased
Serious: no
Organ System: Investigations
Frequency: 8 affected / 14 at risk

Adverse event: Eosinophil count increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Eosinophil percentage decreased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Eosinophil percentage increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Fibrin D dimer increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Fibroblast growth factor 23 increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Flow cytometry
Serious: no
Organ System: Investigations
Frequency: 14 affected / 14 at risk

Adverse event: Glucose urine present
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Glycosylated haemoglobin increased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Immature granulocyte count increased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Haemoglobin decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Haemoglobin urine present
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Haptoglobin decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Haptoglobin increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Hepatitis B core antibody positive
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Hepatitis B surface antigen positive
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Insulin C-peptide increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Low density lipoprotein abnormal
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Lymphocyte percentage decreased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Lymphocyte percentage increased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Mean cell haemoglobin decreased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Mean cell haemoglobin increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Mean cell volume decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Mean cell volume increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Mean platelet volume decreased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Metamyelocyte percentage increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Monocyte percentage decreased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Monocyte percentage increased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Myelocyte percentage increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Neutrophil count decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Neutrophil percentage decreased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Neutrophil percentage increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Nitrite urine present
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: PCO2 decreased
Serious: no
Organ System: Investigations
Frequency: 11 affected / 14 at risk

Adverse event: PCO2 increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: pH urine increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Platelet count decreased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Platelet count increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Platelet morphology abnormal
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: PO2 decreased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: PO2 increased
Serious: no
Organ System: Investigations
Frequency: 11 affected / 14 at risk

Adverse event: Promyelocyte count increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Protein total decreased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Protein total increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Protein urine present
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Prothrombin time shortened
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Red blood cell count decreased
Serious: no
Organ System: Investigations
Frequency: 13 affected / 14 at risk

Adverse event: Red blood cell microcytes present
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Red blood cell morphology abnormal
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Red blood cell poikilocytes present
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Red blood cell sedimentation rate
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Red blood cell sedimentation rate increased
Serious: no
Organ System: Investigations
Frequency: 8 affected / 14 at risk

Adverse event: Red blood cells urine increased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Red cell distribution width increased
Serious: no
Organ System: Investigations
Frequency: 12 affected / 14 at risk

Adverse event: Reticulocyte count decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Reticulocyte count increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Reticulocyte haemoglobin equivalent
Serious: no
Organ System: Investigations
Frequency: 8 affected / 14 at risk

Adverse event: Reticulocyte percentage increased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Serum ferritin decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Serum ferritin increased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Specific gravity urine increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: T-lymphocyte count increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Transferrin increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Transferrin saturation increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Urinary casts present
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Urine albumin/creatinine ratio increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Urine calcium decreased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Urine calcium increased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Urine ketone body present
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: White blood cells urine positive
Serious: no
Organ System: Investigations
Frequency: 8 affected / 14 at risk

Adverse event: Urine magnesium decreased
Serious: no
Organ System: Investigations
Frequency: 12 affected / 14 at risk

Adverse event: Urine magnesium increased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Urine oxalate decreased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Urine oxalate increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Urine phosphorus decreased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Urine phosphorus increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Urine potassium decreased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Urine potassium increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Urine protein/creatinine ratio increased
Serious: no
Organ System: Investigations
Frequency: 12 affected / 14 at risk

Adverse event: Urine sodium decreased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Urine sodium increased
Serious: no
Organ System: Investigations
Frequency: 13 affected / 14 at risk

Adverse event: Urine uric acid decreased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Urine uric acid increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Urobilinogen urine
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Venous oxygen saturation decreased
Serious: no
Organ System: Investigations
Frequency: 14 affected / 14 at risk

Adverse event: Venous oxygen saturation increased
Serious: no
Organ System: Investigations
Frequency: 14 affected / 14 at risk

Adverse event: Vitamin B12 increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Vitamin D decreased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Vitamin D increased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Von Willebrand's factor activity increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: Von Willebrand's factor antigen increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: White blood cell count decreased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: White blood cell count increased
Serious: no
Organ System: Investigations
Frequency: 6 affected / 14 at risk

Adverse event: White blood cells urine positive
Serious: no
Organ System: Investigations
Frequency: 12 affected / 14 at risk

Adverse event: Hypercalcaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 2 affected / 14 at risk

Adverse event: Hyperglycaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 13 affected / 14 at risk

Adverse event: Hyperkalaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 14 at risk

Adverse event: Hypernatraemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 3 affected / 14 at risk

Adverse event: Hyperuricaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 14 at risk

Adverse event: Hypocalcaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 10 affected / 14 at risk

Adverse event: Hypoglycaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 9 affected / 14 at risk

Adverse event: Hypokalaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 13 affected / 14 at risk

Adverse event: Hypomagnesaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 6 affected / 14 at risk

Adverse event: Hyponatraemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 13 affected / 14 at risk

Adverse event: Pain in extremity
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 4 affected / 14 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 5 affected / 14 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 14 at risk

Adverse event: Amino acid level abnormal
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 1 affected / 14 at risk

Adverse event: Blister
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 14 at risk

Adverse event: Pruritus
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 14 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 14 affected / 14 at risk

Adverse event: Hypotension
Serious: no
Organ System: Vascular disorders
Frequency: 6 affected / 14 at risk

Adverse event: Lymphocyte count decreased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Lymphocyte count increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Monocyte count decreased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Monocyte count increased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Neutrophil count decreased
Serious: no
Organ System: Investigations
Frequency: 4 affected / 14 at risk

Adverse event: Neutrophil count increased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Beta 2 microglobulin urine increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Bilirubin conjugated
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Human T-cell lymphotropic virus infection
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 14 at risk

Adverse event: Immature granulocyte percentage increased
Serious: no
Organ System: Investigations
Frequency: 13 affected / 14 at risk

Adverse event: Blood magnesium decreased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Blood magnesium increased
Serious: no
Organ System: Investigations
Frequency: 9 affected / 14 at risk

Adverse event: Blood calcium decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood creatinine increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood glucose increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Blood thyroid stimulating hormone decreased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Blood thyroid stimulating hormone increased
Serious: no
Organ System: Investigations
Frequency: 5 affected / 14 at risk

Adverse event: Catheter site infection
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 14 at risk

Adverse event: Creatinine renal clearance decreased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Creatinine renal clearance increased
Serious: no
Organ System: Investigations
Frequency: 3 affected / 14 at risk

Adverse event: Cystatin C abnormal
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Diastolic hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 5 affected / 14 at risk

Adverse event: Diastolic hypotension
Serious: no
Organ System: Vascular disorders
Frequency: 13 affected / 14 at risk

Adverse event: Erythroblast count increased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Laboratory test
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Lipids abnormal
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Mean cell haemoglobin concentration decreased
Serious: no
Organ System: Investigations
Frequency: 11 affected / 14 at risk

Adverse event: Migraine
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 14 at risk

Adverse event: Nasal congestion
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 14 at risk

Adverse event: Procedural dizziness
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 14 at risk

Adverse event: Prothrombin time prolonged
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Systolic hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 14 affected / 14 at risk

Adverse event: Thyroxine decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Thyroxine free decreased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Transferrin decreased
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Transferrin saturation decreased
Serious: no
Organ System: Investigations
Frequency: 7 affected / 14 at risk

Adverse event: Urea renal clearance decreased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk

Adverse event: Urine calcium oxalate
Serious: no
Organ System: Investigations
Frequency: 2 affected / 14 at risk

Adverse event: Urine protein, quantitative increased
Serious: no
Organ System: Investigations
Frequency: 13 affected / 14 at risk

Adverse event: Blood pH decreased
Serious: no
Organ System: Investigations
Frequency: 10 affected / 14 at risk

Adverse event: Blood pH increased
Serious: no
Organ System: Investigations
Frequency: 1 affected / 14 at risk