Study: NCT00242580

Adverse event: Injury
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 2 affected / 32 at risk

Adverse event: Anaphylactoid reaction
Serious: yes
Organ System: Immune system disorders
Frequency: 1 affected / 32 at risk

Adverse event: Infection
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 32 at risk

Adverse event: Neoplasm
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 32 at risk

Adverse event: Arterial thrombosis
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 32 at risk

Adverse event: Arteriosclerosis
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 32 at risk

Adverse event: Cardiac failure congestive
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 32 at risk

Adverse event: Atrioventricular block
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 32 at risk

Adverse event: Gastrointestinal disorder
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 32 at risk

Adverse event: Hypokalaemia
Serious: yes
Organ System: Metabolism and nutrition disorders
Frequency: 1 affected / 32 at risk

Adverse event: Cerebral ischaemia
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 32 at risk

Adverse event: Pneumonia
Serious: yes
Organ System: Infections and infestations
Frequency: 1 affected / 32 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 2 affected / 32 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 4 affected / 32 at risk

Adverse event: Infection
Serious: no
Organ System: Infections and infestations
Frequency: 5 affected / 32 at risk

Adverse event: Injection site extravasation
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 2 affected / 32 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Frequency: 5 affected / 32 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 7 affected / 32 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 32 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 32 at risk

Adverse event: Gastrointestinal disorder
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 32 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 32 at risk

Adverse event: Hyperlipidaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 2 affected / 32 at risk

Adverse event: Oedema peripheral
Serious: no
Organ System: General disorders
Frequency: 2 affected / 32 at risk

Adverse event: Arthritis
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 32 at risk

Adverse event: Bronchitis
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 32 at risk

Adverse event: Lung disorder
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 32 at risk

Adverse event: Rhinitis
Serious: no
Organ System: Infections and infestations
Frequency: 3 affected / 32 at risk

Adverse event: Sinusitis
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 32 at risk

Adverse event: Skin disorder
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 32 at risk

Adverse event: AMD PROGRESSION (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 5 affected / 32 at risk

Adverse event: CATARACT (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 32 at risk

Adverse event: CONJUNCTIVITIS (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: DRY EYES (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 32 at risk

Adverse event: EYE ITCHING (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: RETINAL DISORDER (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: RETINAL HEMORRHAGE (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 32 at risk

Adverse event: SUBRETINAL HEMORRHAGE (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: ACUTE ELEVATED IOP (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: AMD PROGRESSION (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 6 affected / 32 at risk

Adverse event: BLEPHARITIS (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 32 at risk

Adverse event: CATARACT (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 8 affected / 32 at risk

Adverse event: CONJUNCTIVITIS (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 32 at risk

Adverse event: DRY EYES (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 32 at risk

Adverse event: EYE HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 5 affected / 32 at risk

Adverse event: EYE ITCHING (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: EYE PAIN (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: RETINAL DISORDER (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 32 at risk

Adverse event: RETINAL EDEMA (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 32 at risk

Adverse event: RETINAL HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 32 at risk

Adverse event: RETINAL PIGMENTATION (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 32 at risk

Adverse event: SUBRETINAL HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 32 at risk

Adverse event: VISION ABNORMAL (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 4 affected / 32 at risk

Adverse event: VISION DECREASED (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 32 at risk

Adverse event: Urinary tract infection
Serious: no
Organ System: Renal and urinary disorders
Frequency: 2 affected / 32 at risk

Adverse event: Injury
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 41 at risk

Adverse event: Hernia
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 41 at risk

Adverse event: Aortic stenosis
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 41 at risk

Adverse event: Atrial fibrillation
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 41 at risk

Adverse event: Coronary artery disease
Serious: yes
Organ System: Cardiac disorders
Frequency: 2 affected / 41 at risk

Adverse event: Cholelithiasis
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 41 at risk

Adverse event: Constipation
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 41 at risk

Adverse event: Gastritis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 41 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 41 at risk

Adverse event: Peptic ulcer haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 41 at risk

Adverse event: Cerebral infarction
Serious: yes
Organ System: Nervous system disorders
Frequency: 2 affected / 41 at risk

Adverse event: Cerebrovascular accident
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 41 at risk

Adverse event: Pulmonary oedema
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 41 at risk

Adverse event: Pneumonia
Serious: yes
Organ System: Infections and infestations
Frequency: 2 affected / 41 at risk

Adverse event: Injury
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 2 affected / 41 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 3 affected / 41 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 41 at risk

Adverse event: Infection
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 41 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Frequency: 4 affected / 41 at risk

Adverse event: Coronary artery disease
Serious: no
Organ System: Cardiac disorders
Frequency: 3 affected / 41 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 7 affected / 41 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 41 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 41 at risk

Adverse event: Gastrointestinal disorder
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 41 at risk

Adverse event: Anorectal disorder
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 41 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 3 affected / 41 at risk

Adverse event: Arthritis
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 4 affected / 41 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 41 at risk

Adverse event: Dementia
Serious: no
Organ System: Psychiatric disorders
Frequency: 2 affected / 41 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 3 affected / 41 at risk

Adverse event: Pneumonia
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 41 at risk

Adverse event: Rhinitis
Serious: no
Organ System: Infections and infestations
Frequency: 6 affected / 41 at risk

Adverse event: Sinusitis
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 41 at risk

Adverse event: AMD PROGRESSION (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 6 affected / 41 at risk

Adverse event: CATARACT (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 4 affected / 41 at risk

Adverse event: DRY EYES (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 41 at risk

Adverse event: EYE DISORDER (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 41 at risk

Adverse event: RETINAL DISORDER (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 41 at risk

Adverse event: VISION DECREASED (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 41 at risk

Adverse event: ACUTE ELEVATED IOP (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 7 affected / 41 at risk

Adverse event: AMD PROGRESSION (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 8 affected / 41 at risk

Adverse event: CATARACT (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 10 affected / 41 at risk

Adverse event: DRY EYES (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 41 at risk

Adverse event: EYE HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 7 affected / 41 at risk

Adverse event: EYE PAIN (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 5 affected / 41 at risk

Adverse event: RETINAL DISORDER (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 41 at risk

Adverse event: RETINAL EDEMA (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 4 affected / 41 at risk

Adverse event: RETINAL HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 41 at risk

Adverse event: RETINAL PIGMENTATION (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 41 at risk

Adverse event: SUBRETINAL HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 41 at risk

Adverse event: VISION ABNORMAL (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 5 affected / 41 at risk

Adverse event: VISION DECREASED (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 41 at risk

Adverse event: Urinary tract infection
Serious: no
Organ System: Renal and urinary disorders
Frequency: 5 affected / 41 at risk

Adverse event: Injury
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 3 affected / 38 at risk

Adverse event: Chest pain
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 38 at risk

Adverse event: Cyst
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 38 at risk

Adverse event: Arrhythmia
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 38 at risk

Adverse event: Congenital arterial malformation
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 38 at risk

Adverse event: Coronary artery disease
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 38 at risk

Adverse event: Deep vein thrombosis
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 38 at risk

Adverse event: Myocardial infarction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 38 at risk

Adverse event: Cholecystitis
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 38 at risk

Adverse event: Cholelithiasis
Serious: yes
Organ System: Hepatobiliary disorders
Frequency: 1 affected / 38 at risk

Adverse event: Gastrointestinal disorder
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 38 at risk

Adverse event: Pancreatitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 38 at risk

Adverse event: Osteoporosis
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 38 at risk

Adverse event: Cerebral ischaemia
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 38 at risk

Adverse event: Encephalopathy
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 38 at risk

Adverse event: Vertigo
Serious: yes
Organ System: Ear and labyrinth disorders
Frequency: 1 affected / 38 at risk

Adverse event: Pneumonia
Serious: yes
Organ System: Infections and infestations
Frequency: 2 affected / 38 at risk

Adverse event: Acute kidney injury
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 38 at risk

Adverse event: Injury
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 5 affected / 38 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 3 affected / 38 at risk

Adverse event: Injection site extravasation
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 3 affected / 38 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Frequency: 3 affected / 38 at risk

Adverse event: Coronary artery disease
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 38 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Frequency: 2 affected / 38 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 38 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 38 at risk

Adverse event: Gastrointestinal disorder
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 38 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 38 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 1 affected / 38 at risk

Adverse event: Hyperlipidaemia
Serious: no
Organ System: Metabolism and nutrition disorders
Frequency: 2 affected / 38 at risk

Adverse event: Oedema peripheral
Serious: no
Organ System: General disorders
Frequency: 2 affected / 38 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 2 affected / 38 at risk

Adverse event: Dementia
Serious: no
Organ System: Psychiatric disorders
Frequency: 2 affected / 38 at risk

Adverse event: Insomnia
Serious: no
Organ System: Psychiatric disorders
Frequency: 3 affected / 38 at risk

Adverse event: Bronchitis
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 38 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 2 affected / 38 at risk

Adverse event: Lung disorder
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 2 affected / 38 at risk

Adverse event: Pneumonia
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 38 at risk

Adverse event: Rhinitis
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 38 at risk

Adverse event: Sinusitis
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 38 at risk

Adverse event: Dermatitis contact
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 38 at risk

Adverse event: Pruritus
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 38 at risk

Adverse event: AMD PROGRESSION (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 7 affected / 38 at risk

Adverse event: BLEPHARITIS (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: CATARACT (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: CONJUNCTIVITIS (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: DRY EYES (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 4 affected / 38 at risk

Adverse event: EYE DISORDER (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: RETINAL DISORDER (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: RETINAL HEMORRHAGE (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: Tinnitus
Serious: no
Organ System: Ear and labyrinth disorders
Frequency: 2 affected / 38 at risk

Adverse event: VISION DECREASED (Fellow eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: AMD PROGRESSION (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 38 at risk

Adverse event: BLEPHARITIS (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: CATARACT (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: CONJUNCTIVITIS (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: DRY EYES (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 4 affected / 38 at risk

Adverse event: EYE HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 7 affected / 38 at risk

Adverse event: EYE PAIN (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: RETINAL DISORDER (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 1 affected / 38 at risk

Adverse event: RETINAL PIGMENTATION (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: SUBRETINAL HEMORRHAGE (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 2 affected / 38 at risk

Adverse event: VISION ABNORMAL (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 38 at risk

Adverse event: VISION DECREASED (Study eye)
Serious: no
Organ System: Eye disorders
Frequency: 3 affected / 38 at risk

Adverse event: Urinary tract infection
Serious: no
Organ System: Renal and urinary disorders
Frequency: 5 affected / 38 at risk