Study: NCT00581776

Adverse event: Pain
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Notes: Grade 3 pain, unrelated to investigational therapy
Frequency: 1 affected / 30 at risk

Adverse event: Febrile neutropenia
Serious: yes
Organ System: Investigations
Notes: Febrile neutropenia
Frequency: 4 affected / 30 at risk

Adverse event: Infection
Serious: yes
Organ System: Infections and infestations
Frequency: 9 affected / 30 at risk

Adverse event: Dehydration Gr 3
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 30 at risk

Adverse event: Creatinine Gr 2
Serious: yes
Organ System: Renal and urinary disorders
Frequency: 1 affected / 30 at risk

Adverse event: Dyspnea (shortness of breath)
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 30 at risk

Adverse event: Mucositis - Esophagitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 30 at risk

Adverse event: Thrombosis
Serious: yes
Organ System: Cardiac disorders
Notes: 1 event of picc line clot, one Pulmonary embolus
Frequency: 2 affected / 30 at risk

Adverse event: Myelosuppression
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 30 at risk

Adverse event: progressive disease
Serious: yes
Organ System: General disorders
Notes: admission and death due to progressive lymphoma
Frequency: 1 affected / 30 at risk

Adverse event: Thrombocytopenia Gr 3 or 4
Serious: no
Organ System: Investigations
Frequency: 23 affected / 30 at risk

Adverse event: Neutropenia gr 3 or 4
Serious: no
Organ System: Investigations
Frequency: 20 affected / 30 at risk

Adverse event: Hemoglobin gr 3
Serious: no
Organ System: Investigations
Frequency: 8 affected / 30 at risk

Adverse event: Febrile Neutropenia gr 3
Serious: no
Organ System: Injury, poisoning and procedural complications
Frequency: 5 affected / 30 at risk

Adverse event: Infection with neutropenia
Serious: no
Organ System: Infections and infestations
Frequency: 2 affected / 30 at risk

Adverse event: Infection without neutropenia
Serious: no
Organ System: Infections and infestations
Frequency: 4 affected / 30 at risk

Adverse event: Hyperglycemia gr 3
Serious: no
Organ System: Investigations
Frequency: 4 affected / 30 at risk

Adverse event: hyponatremia gr 3
Serious: no
Organ System: Investigations
Frequency: 4 affected / 30 at risk

Adverse event: Hypophosphatemia gr 3
Serious: no
Organ System: Investigations
Frequency: 1 affected / 30 at risk

Adverse event: Dehydration gr 3
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 30 at risk

Adverse event: Pulmonary Embolism Gr 4
Serious: no
Organ System: Cardiac disorders
Frequency: 1 affected / 30 at risk

Adverse event: Esophagitis Gr 3
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 30 at risk

Adverse event: Mood alteration Gr 3
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Pain gr 3
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 30 at risk

Adverse event: Sensory neuropathy gr 3 and 4
Serious: no
Organ System: Nervous system disorders
Frequency: 9 affected / 30 at risk

Adverse event: Fatigue gr 3
Serious: no
Organ System: General disorders
Frequency: 2 affected / 30 at risk

Adverse event: Hypogammaglobulinaemia
Serious: no
Organ System: Immune system disorders
Frequency: 12 affected / 22 at risk

Adverse event: Infections secondary to hypogammaglobulinemia in maintenance therapy
Serious: no
Organ System: Infections and infestations
Frequency: 6 affected / 22 at risk

Adverse event: delayed neutropenia during rituximab maintenance
Serious: no
Organ System: Investigations
Frequency: 5 affected / 22 at risk