Study: NCT00492401

Adverse event: Documented infection
Serious: no
Organ System: Infections and infestations
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 31 affected / 53 at risk

Adverse event: Febrile neutropenia
Serious: no
Organ System: Infections and infestations
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 5 affected / 53 at risk

Adverse event: Fatigue
Serious: no
Organ System: General disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 3 affected / 53 at risk

Adverse event: Pyrexia
Serious: no
Organ System: General disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 2 affected / 53 at risk

Adverse event: Decreased appetite
Serious: no
Organ System: Metabolism and nutrition disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 1 affected / 53 at risk

Adverse event: Dysgeusia
Serious: no
Organ System: Nervous system disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 1 affected / 53 at risk

Adverse event: Mucositis/gingivitis
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 3 affected / 53 at risk

Adverse event: Dyspnoea
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 3 affected / 53 at risk

Adverse event: Hypoxia
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 8 affected / 53 at risk

Adverse event: Prolonged QTc
Serious: no
Organ System: Investigations
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 2 affected / 53 at risk

Adverse event: Decreased left ventricular ejection fraction
Serious: no
Organ System: Cardiac disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 1 affected / 53 at risk

Adverse event: Arrhythmia
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 3 affected / 53 at risk

Adverse event: Hypertension
Serious: no
Organ System: Vascular disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 2 affected / 53 at risk

Adverse event: Decubitus ulcer
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 1 affected / 53 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 2 affected / 53 at risk

Adverse event: Confusional state
Serious: no
Organ System: Psychiatric disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 1 affected / 53 at risk

Adverse event: Syncope
Serious: no
Organ System: Nervous system disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 3 affected / 53 at risk

Adverse event: Gait disturbance
Serious: no
Organ System: General disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 2 affected / 53 at risk

Adverse event: Pain
Serious: no
Organ System: General disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 7 affected / 53 at risk

Adverse event: Thrombosis
Serious: no
Organ System: Vascular disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 3 affected / 53 at risk

Adverse event: Hemorrhage/hematoma
Serious: no
Organ System: Vascular disorders
Notes: Grade ≥ 3 in cycles 1 and 2
Frequency: 5 affected / 53 at risk