Study: NCT01667250

Adverse event: Worsening of Headache Pain
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Appendicitis
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 30 at risk

Adverse event: Altered sensations (brain zaps)
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Migratory Paresthesia
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Right arm (hand) tremor
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Right eye twitching
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 30 at risk

Adverse event: Lip twiching
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Intermittent Vertigo
Serious: no
Organ System: Ear and labyrinth disorders
Frequency: 1 affected / 30 at risk

Adverse event: Exacerbated migraine
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Lip numbness
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 30 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 30 at risk

Adverse event: Blister at treatment site
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 30 at risk

Adverse event: Malaise
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 30 at risk

Adverse event: Mild pains in head and right arm
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Pruritus
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Worsening of migraine
Serious: no
Organ System: Nervous system disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Blisters at treatment site
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Rash/Blister at treatment site
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Redness at treatment site
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Severe migraine
Serious: no
Organ System: Nervous system disorders
Notes: Open label - phase 3
Frequency: 1 affected / 30 at risk

Adverse event: Exacerbated migraine
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 29 at risk

Adverse event: Atypical migraine pain with associated blackouts
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 29 at risk

Adverse event: Oropharyngeal pain
Serious: no
Organ System: Infections and infestations
Frequency: 1 affected / 29 at risk

Adverse event: Urinary incontinence
Serious: no
Organ System: Renal and urinary disorders
Frequency: 1 affected / 29 at risk

Adverse event: Dysphonia
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 29 at risk

Adverse event: Rash at treatment site
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 1 affected / 29 at risk