Study: NCT00169104

Adverse event: Mental status change
Serious: yes
Organ System: Nervous system disorders
Notes: Grade 3
Frequency: 1 affected / 11 at risk

Adverse event: Thrombocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3
Frequency: 1 affected / 11 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3
Frequency: 3 affected / 11 at risk

Adverse event: Peripheral sensory neuropathy
Serious: no
Organ System: Nervous system disorders
Notes: Grade 2
Frequency: 1 affected / 11 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 2
Frequency: 1 affected / 11 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 2
Frequency: 5 affected / 11 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 2
Frequency: 1 affected / 11 at risk

Adverse event: Leukopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 4
Frequency: 2 affected / 11 at risk

Adverse event: Leukopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 2
Frequency: 3 affected / 11 at risk

Adverse event: Granulocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 4
Frequency: 1 affected / 11 at risk

Adverse event: Granulocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3
Frequency: 2 affected / 11 at risk

Adverse event: Granulocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 2
Frequency: 1 affected / 11 at risk

Adverse event: Elevated alkaline phosphatase
Serious: no
Organ System: Investigations
Notes: Grade 3
Frequency: 2 affected / 11 at risk

Adverse event: Elevated alkaline phosphatase
Serious: no
Organ System: Investigations
Notes: Grade 2
Frequency: 5 affected / 11 at risk

Adverse event: Elevated AST
Serious: no
Organ System: Investigations
Notes: Grade 3
Frequency: 1 affected / 11 at risk

Adverse event: Febrile neutropenia
Serious: yes
Organ System: Immune system disorders
Notes: Grade 3
Frequency: 1 affected / 8 at risk

Adverse event: Peripheral sensory neuropathy
Serious: no
Organ System: Nervous system disorders
Notes: Grade 2
Frequency: 1 affected / 8 at risk

Adverse event: Arthralgias
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Grade 2
Frequency: 2 affected / 8 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 2
Frequency: 1 affected / 8 at risk

Adverse event: Anaemia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 2
Frequency: 4 affected / 8 at risk

Adverse event: Tumour pain
Serious: no
Organ System: Nervous system disorders
Notes: Grade 2
Frequency: 1 affected / 8 at risk

Adverse event: Mucosal inflammation
Serious: no
Organ System: Gastrointestinal disorders
Notes: Grade 2
Frequency: 1 affected / 8 at risk

Adverse event: Thrombocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 2
Frequency: 1 affected / 8 at risk

Adverse event: Leukopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 2
Frequency: 1 affected / 8 at risk

Adverse event: Granulocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 3
Frequency: 1 affected / 8 at risk

Adverse event: Granulocytopenia
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Grade 2
Frequency: 1 affected / 8 at risk

Adverse event: Elevated alkaline phosphatase
Serious: no
Organ System: Investigations
Notes: Grade 3
Frequency: 1 affected / 8 at risk

Adverse event: Elevated alkaline phosphatase
Serious: no
Organ System: Investigations
Notes: Grade 2
Frequency: 2 affected / 8 at risk

Adverse event: Elevated AST
Serious: no
Organ System: Investigations
Notes: Grade 2
Frequency: 2 affected / 8 at risk

Adverse event: Elevated ALT
Serious: no
Organ System: Investigations
Notes: Grade 3
Frequency: 1 affected / 8 at risk

Adverse event: Elevated ALT
Serious: no
Organ System: Investigations
Notes: Grade 2
Frequency: 1 affected / 8 at risk