Study: NCT02657317

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Pain in knee
Frequency: 3 affected / 50 at risk

Adverse event: Increased Anxiety
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 50 at risk

Adverse event: Increased Nightmares
Serious: no
Organ System: Psychiatric disorders
Notes: Subject experience more nightmares than usual
Frequency: 2 affected / 50 at risk

Adverse event: Increased Anger
Serious: no
Organ System: Psychiatric disorders
Frequency: 3 affected / 50 at risk

Adverse event: Pain in right let
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 50 at risk

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 3 affected / 50 at risk

Adverse event: Numbness and tingling in feet
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 50 at risk

Adverse event: Cold and numbness in feet
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 50 at risk

Adverse event: Sleep difficulties due to discontinued opioid
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 50 at risk

Adverse event: Increase in pain due to discontinuation of opioid
Serious: no
Organ System: General disorders
Frequency: 2 affected / 50 at risk

Adverse event: Increased irritability due to discontinuation of opioids
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 50 at risk

Adverse event: Increase in headaches due to discontinuation of opioids
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 50 at risk

Adverse event: Whole body aches
Serious: no
Organ System: General disorders
Frequency: 1 affected / 50 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: new dull pain in mid back possibly due to going swimming
Frequency: 11 affected / 50 at risk

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Pain in knee
Frequency: 7 affected / 53 at risk

Adverse event: Increased Anxiety
Serious: no
Organ System: Nervous system disorders
Frequency: 8 affected / 53 at risk

Adverse event: Pain in right let
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 53 at risk

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 12 affected / 53 at risk

Adverse event: Numbness and tingling in feet
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 53 at risk

Adverse event: Increase in pain due to discontinuation of opioid
Serious: no
Organ System: General disorders
Frequency: 2 affected / 53 at risk

Adverse event: Increased irritability due to discontinuation of opioids
Serious: no
Organ System: Psychiatric disorders
Frequency: 1 affected / 53 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: new dull pain in mid back possibly due to going swimming
Frequency: 10 affected / 53 at risk