Study: NCT02416622

Adverse event: Atrial fibrillation
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 6 at risk

Adverse event: Faecaloma
Serious: yes
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 6 at risk

Adverse event: Cerebellar stroke
Serious: yes
Organ System: Nervous system disorders
Frequency: 1 affected / 6 at risk

Adverse event: Pulmonary embolism
Serious: yes
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 1 affected / 6 at risk

Adverse event: Keratic precipitates
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 6 at risk

Adverse event: Vitritis
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 3 affected / 6 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 6 at risk

Adverse event: Vitreal cells
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 6 at risk

Adverse event: Conjunctival haemorrhage
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 6 at risk

Adverse event: Anterior chamber inflammation
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 6 at risk

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 6 at risk

Adverse event: Eyelid ptosis
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 6 at risk

Adverse event: Injection site haemorrhage
Serious: no
Organ System: General disorders
Notes: Ocular
Frequency: 1 affected / 6 at risk

Adverse event: Intraocular pressure test
Serious: no
Organ System: Investigations
Notes: Ocular
Frequency: 1 affected / 6 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Notes: Non-ocular
Frequency: 1 affected / 6 at risk

Adverse event: Viral upper respiratory tract infection
Serious: no
Organ System: Infections and infestations
Notes: Non-ocular
Frequency: 1 affected / 6 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 1 affected / 6 at risk

Adverse event: Increased appetite
Serious: no
Organ System: Metabolism and nutrition disorders
Notes: Non-ocular
Frequency: 1 affected / 6 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Non-ocular
Frequency: 1 affected / 6 at risk

Adverse event: Retinal detachment
Serious: yes
Organ System: Eye disorders
Frequency: 1 affected / 8 at risk

Adverse event: Keratic precipitates
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Vitritis
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 3 affected / 8 at risk

Adverse event: Anterior chamber cells
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Vitreous floaters
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Vitreal cells
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Conjunctival haemorrhage
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Cataract subcapsular
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Vision blurred
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Vitreous haze
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Visual impairment
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Retinal tear
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Anterior chamber flare
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Photophobia
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Lenticular opacities
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Conjunctival oedema
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Eyelid ptosis
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Lacrimation increased
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Retinal detachment
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Retinal haemorrhage
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Injection site haemorrhage
Serious: no
Organ System: General disorders
Notes: Ocular
Frequency: 2 affected / 8 at risk

Adverse event: Injection site discomfort
Serious: no
Organ System: General disorders
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Intraocular pressure test
Serious: no
Organ System: Investigations
Notes: Ocular
Frequency: 1 affected / 8 at risk

Adverse event: Pyrexia
Serious: no
Organ System: General disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Blood pressure increased
Serious: no
Organ System: Investigations
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: White blood cell count increased
Serious: no
Organ System: Investigations
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Viral upper respiratory tract infection
Serious: no
Organ System: Infections and infestations
Notes: Non-ocular
Frequency: 3 affected / 8 at risk

Adverse event: Abdominal pain upper
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Stomatitis
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Leukocytosis
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Insomnia
Serious: no
Organ System: Psychiatric disorders
Notes: Non-ocular
Frequency: 1 affected / 8 at risk

Adverse event: Retinal detachment
Serious: yes
Organ System: Eye disorders
Frequency: 1 affected / 13 at risk

Adverse event: Keratic precipitates
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 7 affected / 13 at risk

Adverse event: Vitritis
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 5 affected / 13 at risk

Adverse event: Anterior chamber cells
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 8 affected / 13 at risk

Adverse event: Vitreous floaters
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 6 affected / 13 at risk

Adverse event: Eye pain
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 4 affected / 13 at risk

Adverse event: Vitreal cells
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 5 affected / 13 at risk

Adverse event: Conjunctival haemorrhage
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 3 affected / 13 at risk

Adverse event: Cataract subcapsular
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 3 affected / 13 at risk

Adverse event: Vision blurred
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 4 affected / 13 at risk

Adverse event: Vitreous haze
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 4 affected / 13 at risk

Adverse event: Visual impairment
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Anterior chamber inflammation
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Retinal tear
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Anterior chamber flare
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Cataract
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 3 affected / 13 at risk

Adverse event: Conjunctival hyperaemia
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Eye pruritus
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 3 affected / 13 at risk

Adverse event: Photophobia
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Photopsia
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 3 affected / 13 at risk

Adverse event: Lenticular opacities
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 13 at risk

Adverse event: Iridocyclitis
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Lacrimation increased
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 13 at risk

Adverse event: Ocular discomfort
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Retinal detachment
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 13 at risk

Adverse event: Retinal haemorrhage
Serious: no
Organ System: Eye disorders
Notes: Ocular
Frequency: 1 affected / 13 at risk

Adverse event: Injection site haemorrhage
Serious: no
Organ System: General disorders
Notes: Ocular
Frequency: 3 affected / 13 at risk

Adverse event: Injection site discomfort
Serious: no
Organ System: General disorders
Notes: Ocular
Frequency: 1 affected / 13 at risk

Adverse event: Intraocular pressure test
Serious: no
Organ System: Investigations
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Optic neuritis
Serious: no
Organ System: Nervous system disorders
Notes: Ocular
Frequency: 2 affected / 13 at risk

Adverse event: Pyrexia
Serious: no
Organ System: General disorders
Notes: Non-ocular
Frequency: 2 affected / 13 at risk

Adverse event: Feeling hot
Serious: no
Organ System: General disorders
Notes: Non-ocular
Frequency: 2 affected / 13 at risk

Adverse event: Blood pressure increased
Serious: no
Organ System: Investigations
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Weight increased
Serious: no
Organ System: Investigations
Notes: Non-ocular
Frequency: 2 affected / 13 at risk

Adverse event: White blood cell count increased
Serious: no
Organ System: Investigations
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Notes: Non-ocular
Frequency: 3 affected / 13 at risk

Adverse event: Viral upper respiratory tract infection
Serious: no
Organ System: Infections and infestations
Notes: Non-ocular
Frequency: 4 affected / 13 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 3 affected / 13 at risk

Adverse event: Abdominal pain upper
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 2 affected / 13 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Stomatitis
Serious: no
Organ System: Gastrointestinal disorders
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Leukocytosis
Serious: no
Organ System: Blood and lymphatic system disorders
Notes: Non-ocular
Frequency: 4 affected / 13 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Increased appetite
Serious: no
Organ System: Metabolism and nutrition disorders
Notes: Non-ocular
Frequency: 3 affected / 13 at risk

Adverse event: Arthralgia
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Back pain
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Notes: Non-ocular
Frequency: 1 affected / 13 at risk

Adverse event: Oropharyngeal pain
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Notes: Non-ocular
Frequency: 2 affected / 13 at risk

Adverse event: Insomnia
Serious: no
Organ System: Psychiatric disorders
Notes: Non-ocular
Frequency: 3 affected / 13 at risk