Study: NCT00894166

Adverse event: Chest Pain, myocardial infarction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 132 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: Neoplasms benign, malignant and unspecified (incl cysts and polyps)
Frequency: 1 affected / 132 at risk

Adverse event: Rash distant from patch site
Serious: yes
Organ System: Immune system disorders
Frequency: 1 affected / 132 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 18 affected / 132 at risk

Adverse event: EXCESSIVE SWEATING
Serious: no
Organ System: General disorders
Frequency: 7 affected / 132 at risk

Adverse event: Swelling
Serious: no
Organ System: General disorders
Frequency: 3 affected / 132 at risk

Adverse event: MOUTH/THROAT IRRITATION
Serious: no
Organ System: General disorders
Frequency: 11 affected / 132 at risk

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 14 affected / 132 at risk

Adverse event: Thirst
Serious: no
Organ System: General disorders
Frequency: 19 affected / 132 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 10 affected / 132 at risk

Adverse event: JOINT / MUSCLE PAIN
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 14 affected / 132 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 9 affected / 132 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 9 affected / 132 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 7 affected / 132 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 8 affected / 132 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 132 at risk

Adverse event: Irritability
Serious: no
Organ System: Nervous system disorders
Frequency: 20 affected / 132 at risk

Adverse event: Nightmare
Serious: no
Organ System: Nervous system disorders
Frequency: 8 affected / 132 at risk

Adverse event: Abnormal dreams
Serious: no
Organ System: Nervous system disorders
Frequency: 36 affected / 132 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 20 affected / 132 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 3 affected / 132 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 14 affected / 132 at risk

Adverse event: Tremor
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 132 at risk

Adverse event: DECREASED LIBIDO
Serious: no
Organ System: Nervous system disorders
Frequency: 5 affected / 132 at risk

Adverse event: ITCHING/BURNING AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 27 affected / 132 at risk

Adverse event: RASH AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 17 affected / 132 at risk

Adverse event: RASH DISTANT FROM PATCH SITE
Serious: no
Organ System: General disorders
Frequency: 4 affected / 132 at risk

Adverse event: Chest Pain, shortness of breath, vision loss
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 109 at risk

Adverse event: Hives, itching, knot in throat
Serious: yes
Organ System: Injury, poisoning and procedural complications
Frequency: 1 affected / 109 at risk

Adverse event: urticaria and shortness of breath
Serious: yes
Organ System: Immune system disorders
Frequency: 1 affected / 109 at risk

Adverse event: paroxsymal supraventricular tachycardia and fainting
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 109 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 17 affected / 109 at risk

Adverse event: EXCESSIVE SWEATING
Serious: no
Organ System: General disorders
Frequency: 12 affected / 109 at risk

Adverse event: Swelling
Serious: no
Organ System: General disorders
Frequency: 1 affected / 109 at risk

Adverse event: MOUTH/THROAT IRRITATION
Serious: no
Organ System: General disorders
Frequency: 7 affected / 109 at risk

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 19 affected / 109 at risk

Adverse event: Thirst
Serious: no
Organ System: General disorders
Frequency: 21 affected / 109 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 11 affected / 109 at risk

Adverse event: Chest pain
Serious: no
Organ System: General disorders
Frequency: 1 affected / 109 at risk

Adverse event: JOINT / MUSCLE PAIN
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 4 affected / 109 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 7 affected / 109 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 109 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 9 affected / 109 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 109 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 109 at risk

Adverse event: Irritability
Serious: no
Organ System: Nervous system disorders
Frequency: 16 affected / 109 at risk

Adverse event: Nightmare
Serious: no
Organ System: Nervous system disorders
Frequency: 5 affected / 109 at risk

Adverse event: Abnormal dreams
Serious: no
Organ System: Nervous system disorders
Frequency: 35 affected / 109 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 26 affected / 109 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 3 affected / 109 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 16 affected / 109 at risk

Adverse event: Tremor
Serious: no
Organ System: Nervous system disorders
Frequency: 5 affected / 109 at risk

Adverse event: DECREASED LIBIDO
Serious: no
Organ System: Nervous system disorders
Frequency: 4 affected / 109 at risk

Adverse event: ITCHING/BURNING AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 19 affected / 109 at risk

Adverse event: RASH AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 8 affected / 109 at risk

Adverse event: RASH DISTANT FROM PATCH SITE
Serious: no
Organ System: General disorders
Frequency: 3 affected / 109 at risk

Adverse event: psychiatric side effects
Serious: yes
Organ System: Psychiatric disorders
Frequency: 1 affected / 112 at risk

Adverse event: Chest pain, unifocal PVCs
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 112 at risk

Adverse event: Body aches, generalized weakness, sensation of throat swelling, lightheadedness,difficulty breathing
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 112 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 9 affected / 112 at risk

Adverse event: EXCESSIVE SWEATING
Serious: no
Organ System: General disorders
Frequency: 4 affected / 112 at risk

Adverse event: Swelling
Serious: no
Organ System: General disorders
Frequency: 3 affected / 112 at risk

Adverse event: MOUTH/THROAT IRRITATION
Serious: no
Organ System: General disorders
Frequency: 2 affected / 112 at risk

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 7 affected / 112 at risk

Adverse event: Thirst
Serious: no
Organ System: General disorders
Frequency: 12 affected / 112 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 15 affected / 112 at risk

Adverse event: JOINT / MUSCLE PAIN
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 4 affected / 112 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 112 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 112 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 112 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 112 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 6 affected / 112 at risk

Adverse event: Irritability
Serious: no
Organ System: Nervous system disorders
Frequency: 18 affected / 112 at risk

Adverse event: Nightmare
Serious: no
Organ System: Nervous system disorders
Frequency: 8 affected / 112 at risk

Adverse event: Abnormal dreams
Serious: no
Organ System: Nervous system disorders
Frequency: 25 affected / 112 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 14 affected / 112 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 6 affected / 112 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 8 affected / 112 at risk

Adverse event: Tremor
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 112 at risk

Adverse event: DECREASED LIBIDO
Serious: no
Organ System: Nervous system disorders
Frequency: 6 affected / 112 at risk

Adverse event: ITCHING/BURNING AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 13 affected / 112 at risk

Adverse event: RASH AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 6 affected / 112 at risk

Adverse event: RASH DISTANT FROM PATCH SITE
Serious: no
Organ System: General disorders
Frequency: 2 affected / 112 at risk

Adverse event: Hallucinations, chest pains, vomiting
Serious: yes
Organ System: General disorders
Frequency: 1 affected / 114 at risk

Adverse event: stroke and death
Serious: yes
Organ System: Vascular disorders
Frequency: 1 affected / 114 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 17 affected / 114 at risk

Adverse event: EXCESSIVE SWEATING
Serious: no
Organ System: General disorders
Frequency: 12 affected / 114 at risk

Adverse event: Swelling
Serious: no
Organ System: General disorders
Frequency: 2 affected / 114 at risk

Adverse event: MOUTH/THROAT IRRITATION
Serious: no
Organ System: General disorders
Frequency: 4 affected / 114 at risk

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 18 affected / 114 at risk

Adverse event: Thirst
Serious: no
Organ System: General disorders
Frequency: 23 affected / 114 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 13 affected / 114 at risk

Adverse event: Chest pain
Serious: no
Organ System: General disorders
Frequency: 1 affected / 114 at risk

Adverse event: JOINT / MUSCLE PAIN
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 9 affected / 114 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 114 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 114 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 6 affected / 114 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 6 affected / 114 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 114 at risk

Adverse event: Irritability
Serious: no
Organ System: Nervous system disorders
Frequency: 15 affected / 114 at risk

Adverse event: Nightmare
Serious: no
Organ System: Nervous system disorders
Frequency: 9 affected / 114 at risk

Adverse event: Abnormal dreams
Serious: no
Organ System: Nervous system disorders
Frequency: 39 affected / 114 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 20 affected / 114 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 8 affected / 114 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 9 affected / 114 at risk

Adverse event: DECREASED LIBIDO
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 114 at risk

Adverse event: ITCHING/BURNING AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 30 affected / 114 at risk

Adverse event: RASH AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 10 affected / 114 at risk

Adverse event: RASH DISTANT FROM PATCH SITE
Serious: no
Organ System: General disorders
Frequency: 4 affected / 114 at risk

Adverse event: Chest Pain worsened with inspiration
Serious: yes
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 1 affected / 34 at risk

Adverse event: chest pain, new left bundle branch block
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 34 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 5 affected / 34 at risk

Adverse event: EXCESSIVE SWEATING
Serious: no
Organ System: General disorders
Frequency: 4 affected / 34 at risk

Adverse event: Swelling
Serious: no
Organ System: General disorders
Frequency: 2 affected / 34 at risk

Adverse event: MOUTH/THROAT IRRITATION
Serious: no
Organ System: General disorders
Frequency: 2 affected / 34 at risk

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 8 affected / 34 at risk

Adverse event: Thirst
Serious: no
Organ System: General disorders
Frequency: 10 affected / 34 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 4 affected / 34 at risk

Adverse event: Chest pain
Serious: no
Organ System: General disorders
Frequency: 3 affected / 34 at risk

Adverse event: JOINT / MUSCLE PAIN
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 7 affected / 34 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 34 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 34 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 34 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 34 at risk

Adverse event: Irritability
Serious: no
Organ System: Nervous system disorders
Frequency: 9 affected / 34 at risk

Adverse event: Abnormal dreams
Serious: no
Organ System: Nervous system disorders
Frequency: 12 affected / 34 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 11 affected / 34 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 6 affected / 34 at risk

Adverse event: Tremor
Serious: no
Organ System: Nervous system disorders
Frequency: 2 affected / 34 at risk

Adverse event: DECREASED LIBIDO
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 34 at risk

Adverse event: ITCHING/BURNING AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 10 affected / 34 at risk

Adverse event: RASH AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 2 affected / 34 at risk

Adverse event: RASH DISTANT FROM PATCH SITE
Serious: no
Organ System: General disorders
Frequency: 1 affected / 34 at risk

Adverse event: myocardial infaction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 36 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 6 affected / 36 at risk

Adverse event: EXCESSIVE SWEATING
Serious: no
Organ System: General disorders
Frequency: 3 affected / 36 at risk

Adverse event: MOUTH/THROAT IRRITATION
Serious: no
Organ System: General disorders
Frequency: 1 affected / 36 at risk

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 4 affected / 36 at risk

Adverse event: Thirst
Serious: no
Organ System: General disorders
Frequency: 8 affected / 36 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 5 affected / 36 at risk

Adverse event: Chest pain
Serious: no
Organ System: General disorders
Frequency: 2 affected / 36 at risk

Adverse event: JOINT / MUSCLE PAIN
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 3 affected / 36 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 36 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 36 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 36 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 36 at risk

Adverse event: Irritability
Serious: no
Organ System: Nervous system disorders
Frequency: 12 affected / 36 at risk

Adverse event: Nightmare
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 36 at risk

Adverse event: Abnormal dreams
Serious: no
Organ System: Nervous system disorders
Frequency: 14 affected / 36 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 6 affected / 36 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 2 affected / 36 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 2 affected / 36 at risk

Adverse event: ITCHING/BURNING AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 7 affected / 36 at risk

Adverse event: RASH AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 3 affected / 36 at risk

Adverse event: myocardial infaction
Serious: yes
Organ System: Cardiac disorders
Frequency: 1 affected / 35 at risk

Adverse event: Headache
Serious: no
Organ System: Nervous system disorders
Frequency: 4 affected / 35 at risk

Adverse event: EXCESSIVE SWEATING
Serious: no
Organ System: General disorders
Frequency: 6 affected / 35 at risk

Adverse event: MOUTH/THROAT IRRITATION
Serious: no
Organ System: General disorders
Frequency: 4 affected / 35 at risk

Adverse event: Dry mouth
Serious: no
Organ System: General disorders
Frequency: 8 affected / 35 at risk

Adverse event: Thirst
Serious: no
Organ System: General disorders
Frequency: 8 affected / 35 at risk

Adverse event: Cough
Serious: no
Organ System: Respiratory, thoracic and mediastinal disorders
Frequency: 6 affected / 35 at risk

Adverse event: JOINT / MUSCLE PAIN
Serious: no
Organ System: Musculoskeletal and connective tissue disorders
Frequency: 4 affected / 35 at risk

Adverse event: Dyspepsia
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 35 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 3 affected / 35 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 4 affected / 35 at risk

Adverse event: Abdominal discomfort
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 2 affected / 35 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 1 affected / 35 at risk

Adverse event: Irritability
Serious: no
Organ System: Nervous system disorders
Frequency: 7 affected / 35 at risk

Adverse event: Nightmare
Serious: no
Organ System: Nervous system disorders
Frequency: 7 affected / 35 at risk

Adverse event: Abnormal dreams
Serious: no
Organ System: Nervous system disorders
Frequency: 17 affected / 35 at risk

Adverse event: Insomnia
Serious: no
Organ System: Nervous system disorders
Frequency: 9 affected / 35 at risk

Adverse event: Depression
Serious: no
Organ System: Psychiatric disorders
Frequency: 3 affected / 35 at risk

Adverse event: Anxiety
Serious: no
Organ System: Psychiatric disorders
Frequency: 7 affected / 35 at risk

Adverse event: DECREASED LIBIDO
Serious: no
Organ System: Nervous system disorders
Frequency: 1 affected / 35 at risk

Adverse event: ITCHING/BURNING AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 11 affected / 35 at risk

Adverse event: RASH AT PATCH SITE
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 6 affected / 35 at risk

Adverse event: RASH DISTANT FROM PATCH SITE
Serious: no
Organ System: General disorders
Frequency: 2 affected / 35 at risk