Study: NCT01669915

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 41 affected / 1710 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 62 affected / 1710 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 25 affected / 1710 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 12 affected / 1710 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 37 affected / 1710 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 432 affected / 1710 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 43 affected / 1710 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 79 affected / 1710 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 5 affected / 1710 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 513 affected / 1710 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 355 affected / 1710 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 568 affected / 1710 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 575 affected / 1710 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 229 affected / 1710 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 229 affected / 1710 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 24 affected / 1710 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 11 affected / 1710 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 352 affected / 1710 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 26 affected / 1714 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 51 affected / 1714 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 33 affected / 1714 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 5 affected / 1714 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 22 affected / 1714 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 411 affected / 1714 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 56 affected / 1714 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 81 affected / 1714 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 6 affected / 1714 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 487 affected / 1714 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 346 affected / 1714 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 573 affected / 1714 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 600 affected / 1714 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 251 affected / 1714 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 231 affected / 1714 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 25 affected / 1714 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 8 affected / 1714 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 361 affected / 1714 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 42 affected / 1699 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 54 affected / 1699 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 34 affected / 1699 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 10 affected / 1699 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 35 affected / 1699 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 429 affected / 1699 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 50 affected / 1699 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 88 affected / 1699 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 6 affected / 1699 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 505 affected / 1699 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 364 affected / 1699 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 547 affected / 1699 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 584 affected / 1699 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 240 affected / 1699 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 234 affected / 1699 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 24 affected / 1699 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 9 affected / 1699 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 344 affected / 1699 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 25 affected / 1725 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 59 affected / 1725 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 24 affected / 1725 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 7 affected / 1725 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 24 affected / 1725 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 414 affected / 1725 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 49 affected / 1725 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 72 affected / 1725 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 5 affected / 1725 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 495 affected / 1725 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 337 affected / 1725 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 594 affected / 1725 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 591 affected / 1725 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 240 affected / 1725 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 226 affected / 1725 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 25 affected / 1725 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 10 affected / 1725 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 369 affected / 1725 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 26 affected / 844 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 30 affected / 844 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 14 affected / 844 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 8 affected / 844 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 24 affected / 844 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 213 affected / 844 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 23 affected / 844 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 41 affected / 844 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 3 affected / 844 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 258 affected / 844 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 182 affected / 844 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 268 affected / 844 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 286 affected / 844 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 109 affected / 844 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 120 affected / 844 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 12 affected / 844 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 6 affected / 844 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 165 affected / 844 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 15 affected / 866 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 32 affected / 866 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 11 affected / 866 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 4 affected / 866 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 13 affected / 866 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 219 affected / 866 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 20 affected / 866 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 38 affected / 866 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 2 affected / 866 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 255 affected / 866 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 173 affected / 866 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 300 affected / 866 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 289 affected / 866 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 120 affected / 866 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 109 affected / 866 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 12 affected / 866 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 5 affected / 866 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 187 affected / 866 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 16 affected / 855 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 24 affected / 855 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 20 affected / 855 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 2 affected / 855 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 11 affected / 855 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 216 affected / 855 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 27 affected / 855 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 47 affected / 855 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 3 affected / 855 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 247 affected / 855 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 182 affected / 855 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 279 affected / 855 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 298 affected / 855 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 131 affected / 855 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 114 affected / 855 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 12 affected / 855 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 3 affected / 855 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 179 affected / 855 at risk

Adverse event: Death
Serious: yes
Organ System: General disorders
Notes: Death
Frequency: 10 affected / 859 at risk

Adverse event: Neoplasm malignant
Serious: yes
Organ System: General disorders
Notes: Cancer
Frequency: 27 affected / 859 at risk

Adverse event: Gastrointestinal haemorrhage
Serious: yes
Organ System: Gastrointestinal disorders
Notes: Gastrointestinal bleeding
Frequency: 13 affected / 859 at risk

Adverse event: Hypercalcaemia
Serious: yes
Organ System: Blood and lymphatic system disorders
Frequency: 3 affected / 859 at risk

Adverse event: Major cardiovascular event
Serious: yes
Organ System: Cardiac disorders
Frequency: 11 affected / 859 at risk

Adverse event: Easy bruising
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 195 affected / 859 at risk

Adverse event: Frequent nosebleeds
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 29 affected / 859 at risk

Adverse event: Blood urine present
Serious: no
Organ System: Blood and lymphatic system disorders
Frequency: 34 affected / 859 at risk

Adverse event: Parathyroid condition
Serious: no
Organ System: Endocrine disorders
Frequency: 3 affected / 859 at risk

Adverse event: Stomach upset of pain
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 240 affected / 859 at risk

Adverse event: Nausea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 164 affected / 859 at risk

Adverse event: Constipation
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 294 affected / 859 at risk

Adverse event: Diarrhoea
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 302 affected / 859 at risk

Adverse event: Increased burping
Serious: no
Organ System: Gastrointestinal disorders
Frequency: 120 affected / 859 at risk

Adverse event: Bad taste in mouth
Serious: no
Organ System: General disorders
Frequency: 117 affected / 859 at risk

Adverse event: Nephrolithiasis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 13 affected / 859 at risk

Adverse event: Kidney failure or dialysis
Serious: no
Organ System: Renal and urinary disorders
Frequency: 5 affected / 859 at risk

Adverse event: Rash
Serious: no
Organ System: Skin and subcutaneous tissue disorders
Frequency: 182 affected / 859 at risk