Please assess the completion status of the following clinical trial:

Trial Title: Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory Philadelphia Chromosome-Positive Acute Lymphoblastic Leukemia

Study Design Characteristics:
- Allocation: None
- Intervention Model: SINGLE_GROUP
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE1/PHASE2
- Number of Arms: 1.0

Eligibility Criteria:
Inclusion Criteria:~* Patients must have histologically confirmed BCR-ABL1 associated (Ph+) acute lymphoblastic leukemia (ALL) with primary refractory or relapsed disease; demonstration of BCR-ABL1 in leukemia cells by one or more of the following is required: t(9;22)(q34;q11.2) cytogenetics; FISH for BCR-ABL1 fusion; RT-PCR for BCR-ABL1 fusion~* Prior treatment with tyrosine kinase inhibitors (including imatinib, nilotinib and/or dasatinib) is allowed, although patients must be off any tyrosine kinase inhibitor for a minimum of 72 hours prior to beginning protocol therapy~* ECOG performance status of 0, 1 or 2~* Total WBC =\< 150,000 with no evidence for ongoing or impending leukostasis~* Total bilirubin =\< 2.0 mg/dL unless elevated due to Gilbert's, hemolysis or leukemic infiltration~* Aspartate transaminase (AST)/alanine transaminase (ALT) =\< 2.5 × upper limit of normal (ULN) unless due to leukemic infiltration~* Serum creatinine =\< 2.0 mg/dL or creatinine clearance \> 50 ml/min~* Left ventricular ejection fraction (LVEF) \>= 45% as measured by echocardiogram (ECHO) or MUGA~* Patients who have undergone stem cell transplantation (SCT), autologous or allogeneic, are eligible provided that they are \> 4 weeks from stem cell infusion, have no active GVHD, and meet other eligibility criteria~* Patients who fail primary induction therapy or relapse after achieving complete remission (CR) are eligible if they are \> 3 weeks off cytotoxic chemotherapy and \> 2 weeks off radiation therapy; patients must be off biologic therapies including hematopoietic growth factors \> 1 week; if using hydroxyurea (HU), steroids, or other non-cytotoxics for blast count control, patient must be off for \> 24 hrs before starting protocol therapy; patients must have recovered from all acute toxicities from any previous therapy~* Female patients of childbearing age must have negative pregnancy test; women of child-bearing potential and men must agree to use adequate contraception (hormonal or barrier method of birth control; abstinence) prior to study entry and for the duration of study participation; should a woman become pregnant or suspect she is pregnant while participating in this study, she should inform her treating physician immediately~* Ability to understand and the willingness to sign a written informed consent document~Exclusion Criteria:~* Patients may not be receiving any other investigational agents~* Active CNS leukemia; patients with known previous CNS leukemia may continue to receive intrathecal therapy with ara-C, methotrexate, and/or thiotepa plus steroids as prophylaxis against reactivation of previous CNS disease~* Patients may not have received previous treatment with entinostat or other HDAC inhibitors~* History of allergic reactions attributed to compounds of similar chemical or biologic composition to entinostat or other agents used in study~* Uncontrolled intercurrent illness including, but not limited to, ongoing or active untreated infection, symptomatic congestive heart failure, unstable angina pectoris, unstable cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements~* Pregnant women are excluded from this study; breastfeeding should be discontinued if the mother is treated with entinostat~* HIV-positive patients on combination antiretroviral therapy are ineligible

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Treatment (entinostat and imatinib mesylate) (Type: EXPERIMENTAL): Patients receive entinostat PO daily on days 1, 8, 15, and 22 and imatinib mesylate PO twice daily on days 1-28 (days 4-28 of course 1). Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: enrollment issues