Please assess the completion status of the following clinical trial:

Trial Title: Anti-EGFR Therapy Rechallenge in Combination With Chemotherapy in Patients With Advanced Colorectal Cancer

Study Design Characteristics:
- Allocation: None
- Intervention Model: SINGLE_GROUP
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE2
- Number of Arms: 1.0

Eligibility Criteria:
Inclusion Criteria:~* Signed and dated informed consent, and willing and able to comply with protocol requirements,~* Histologically proven adenocarcinoma of the colon and/or rectum,~* Metastatic disease confirmed clinically/radiologically,~* Patients with Formalin-Fixed, Paraffin-Embedded tissue RAS wild type colorectal cancer at diagnosis, who had initial clinical benefit \[complete response, partial response or stable disease\] during first line irinotecan-based or oxaliplatin-based chemotherapy in combination with cetuximab or panitumumab,~* First- line treatment duration (FOLFIRI, FOLFOX with anti-EGFR monoclonal antibody, of whom at least 2/3 of cases will have involved panitumumab) of at least 3 months,~* Second line therapy consisting of any chemotherapy (with or without Bevacizumab) definitely without anti-EGFR therapy of at least 2 months, followed by disease progression,~* Eligible third line regimens include FOLFIRI or Irinotecan or FOLFOX, according to standard practice and approved indications. It is required that the third line regimen used will be different from the second line and similar to the first line regimen,~* At least one measurable or evaluable lesion as assessed by computed tomography scan or Magnetic Resonance Imaging according to RECIST version 1.1,~* First course of treatment planned less than 1 week (7 days) after registration,~* Age ≥18 years,~* Eastern Cooperative Oncology Group (ECOG) Performance status 0-2,~* Adequate hematological status: neutrophils (ANC) ≥1.5x109/L; platelets ≥100x109/L; haemoglobin ≥9g/dL,~* Adequate renal function: serum creatinine level \<1.5 mg/dL or Glomelular Filtration Rate (GFR) \>50mL/min by Cockroft/Gault formula,~* Adequate liver function: serum bilirubin ≤1.5 x upper normal limit (ULN), alkaline phosphatase, Aspartate aminotransferase (AST), Alanine aminotransferase (ALT) \<5xULN,~* Regular follow up feasible.~* For female patients of childbearing potential, negative serum or urine pregnancy test within 1 week (7 days) prior of starting study treatment~* Female patients must commit to using reliable and appropriate methods of contraception until at least three months after the end of study treatment (when applicable). Male patients with a partner of childbearing potential must agree to use contraception in addition to having their partner use another contraceptive method during the trial,~* Archival tumor tissue is required for exploratory research at enrolment,~* Ability to undergo plasma sampling during the therapy course.~Exclusion Criteria:~* Presence of central nervous system metastasis unless adequately treated (e.g. non irradiated central nervous system metastasis, seizures not controlled with standard medical therapy constitute non-eligibility criteria),~* Active infection (ie, body temperature ≥38°C due to infection),~* Intestinal obstruction, pulmonary fibrosis or interstitial pneumonitis, renal failure, liver failure, or cerebrovascular disorder,~* Uncontrolled diabetes,~* Myocardial infarction within the last 6 months, severe/unstable angina, symptomatic congestive heart failure New York Heart Association class III or IV,~* Known human immunodeficiency virus or acquired immunodeficiency syndrome-related illness, or hepatitis B or C,~* Autoimmune disorders or history of organ transplantation that require immunosuppressive therapy,~* Other concomitant or previous malignancy, except: i/ adequately treated in-situ carcinoma of the uterine cervix, ii/ basal or squamous cell carcinoma of the skin, iii/ cancer in complete remission for \>5 years,~* Major surgery or traumatic injury within the last 28 days,~* Pregnant or breastfeeding women,~* Patients with known allergy to any excipients to study drugs,~* Other serious and uncontrolled chronic non-malignant disease,~* Known dihydropyrimidine dehydrogenase deficiency,~* Palliative radiation therapy within 4 weeks prior to registration,~* Life expectancy less than 12 weeks in the opinion of the Investigator,~* Treatment with any other investigational medicinal product within 28 days prior to study entry.

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Panitumumab (Type: EXPERIMENTAL): On day 1 of each cycle patients will receive panitumumab followed by 5-fluorouracil and leucovorin in combination with either irinotecan (FOLFIRI regimen) or oxaliplatin (FOLFOX regimen) or followed by irinotecan monotherapy. This treatment will be repeated every 2 weeks for FOLFIRI and FOLFOX regimens and every 3 weeks for irinotecan monotherapy.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: enrollment issues