Please assess the completion status of the following clinical trial:

Trial Title: Safety, Tolerability and Pharmacodynamics of SYNB1020

Study Design Characteristics:
- Allocation: RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: QUADRUPLE
- Phase: PHASE1/PHASE2
- Number of Arms: 3.0

Eligibility Criteria:
Key Inclusion Criteria:~* Age ≥ 18 to \< 75 years~* Females must have been of non-childbearing potential~* Able and willing to complete informed consent process~* Available for and agreed to all study procedures~* Screening laboratory evaluations within defined acceptable limits or judged to be not clinically significant by the Investigator~* Diagnosis of chronic, stable, hepatic insufficiency with features of cirrhosis due to any etiology~* Evidence of elevated portal hypertension by either liver stiffness measurement, the presence of abdominal or esophageal varices, splenomegaly or ascites (Part 2 only)~* Elevated venous ammonia (Part 2 only)~Key Exclusion Criteria:~* Body mass index \< 18.5 or ≥ 40 kg/m\^2~* Administration or ingestion of an investigational drug within 8 weeks or 5 half-lives, whichever was longer, prior to screening or current enrollment in an investigational study~* Allergy to ranitidine or intolerance to any of the excipients (glycerol, CS Health Easy Fiber)~* Any condition, prescription medication or over-the-counter product that may possibly have affected absorption of medications or nutrients~* Dependence on drugs of abuse~* Apart from chronic liver disease, any acute or chronic medical, surgical, psychiatric, or social condition including history of cerebrovascular disease (stroke, transient ischemic attack) or dementia, or laboratory abnormality that may have increased the subject risk associated with study participation, compromised adherence to study procedures and requirements, confounded interpretation of the safety, kinetics, or PD results, and, in the judgment of the Investigator, made the subject inappropriate for enrollment~* Current or past hepatic encephalopathy of Grade 2 or higher requiring hospitalization~* Child-Turcotte-Pugh score \> 9~* History of liver transplant

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: 74 Years
- Healthy Volunteers: f

Study Arms:
- Part 1: SYNB1020 (Type: EXPERIMENTAL): Part 1 comprised a sentinel open-label cohort of subjects enrolled sequentially to receive SYNB1020, which was administered orally at a dose of 5 × 10\^11 colony-forming units (CFU) 3 times daily (TID) given immediately after meals from Days 1 through 6.
- Part 2: SYNB1020 (Type: EXPERIMENTAL): Subjects randomized to receive SYNB1020 in Part 2 received SYNB1020 administered orally at a dose of 5 × 10\^11 CFU TID given immediately after meals from Days 1 through 6.
- Part 2: Placebo (Type: PLACEBO_COMPARATOR): Subjects randomized to receive control in Part 2 received matching placebo (100 mL masking solution) administered orally TID given immediately after meals from Days 1 through 6.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: lack of efficacy