Please assess the completion status of the following clinical trial:

Trial Title: Personalized Targeted Inhibitors Treatment in Renal Cell Cancer

Study Design Characteristics:
- Allocation: None
- Intervention Model: SINGLE_GROUP
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE2
- Number of Arms: 1.0

Eligibility Criteria:
Inclusion Criteria:~* Subjects may be included in the study only if they meet all of the following inclusion criteria:~  * Pathologically confirmed renal cell carcinoma.~ * No prior systemic and/or investigative therapy of any kind.~    * Patients with primary tumor in place are strongly encouraged to undergo nephrectomy prior to initiation of study agent.~   * Prior palliative radiotherapy to metastatic lesion(s) is permitted. Patient must have adequately recovered from the acute toxicities of this treatment.~   * All major surgery of any type and/or radiotherapy must be completed at least 4 weeks prior to registration.~ * Must have progressive metastatic disease~ * ECOG performance status ≤2~ * Women of childbearing potential and male patients must use acceptable methods of contraception-tubal ligation, vasectomy, barrier contraceptive with spermicide-while on study and for 3 months after the last dose of study therapy. Oral, implantable, or injectable contraceptives may be affected by cytochrome P450 interactions, and are therefore not considered effective for this study.~ * Age ≥18 years~ * Required Initial Laboratory Values:~    * Granulocytes ≥1,500/µL~   * Platelet Count ≥100,000/µL~   * Hemoglobin ≥9 g/dL~   * AST/ALT ≤ 2.5 times the upper limit of normal (ULN)~   * Alk. Phos.≤ 2.5 x ULN~   * Serum bilirubin ≤ 1.5 x ULN~   * Amylase/Lipase within normal range~   * Urinalysis≤ 1+ protein~   * T3T4 TSH - within normal range~   * Pregnancy test for women - Negative~   * Serum creatinine ≤ 1.5 x ULN~   * Electrocardiogram (ECG) - no active ischemia~   * Echocardiogram ejection fraction ≥40%~   * Pulmonary function tests~   * Fasting serum cholesterol ≤300 mg/dL OR ≤7.75 mmol/L AND fasting triglycerides ≤2.5 x ULN. NOTE: In case one or both of these thresholds are exceeded, the patient can only be included after initiation of appropriate lipid lowering medication.~ * Signed informed consent prior to the performance of any study-specific procedures~Exclusion Criteria:~* Ongoing hemoptysis, or cerebrovascular accident within 12 months prior to study entry, or peripheral vascular disease with claudication occurring upon walking less than one city block, or history of clinically significant bleeding.~* Deep venous thrombosis or pulmonary embolus within 12 months prior to study entry and no ongoing need for full-dose oral or parenteral anticoagulation. For maintenance of catheter patency daily prophylactic aspirin or low-dose coumadin (1-2 mg) is allowed.~* Evidence of current central nervous system (CNS) metastases. All patients must undergo a CT scan of the brain (with contrast, if possible) within 42 days prior to registration. Any imaging abnormality indicative of active CNS metastases will exclude the patient from the study.~* Significant cardiovascular disease defined as congestive heart failure (New York Heart Association Class II, II or IV) angina pectoris requiring nitrate therapy, or recent myocardial infarction (within the preceding 6 months prior to study entry).~* Uncontrolled hypertension (defined as blood pressure of ≥160 mmHg systolic and/or ≥90 mmHg diastolic on medication). Document over 48 hours with minimum of 3 readings.~* Ongoing requirement for systemic corticosteroid therapy (except replacement therapy for adrenal insufficiency) or other immunosuppressants are not permitted. Topical and/or inhaled steroids are allowed.

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Personalized therapy (Type: OTHER): Subjects will receive one of the four first-line therapy agents based on their tumor's profile. The first-line agents are sunitinib, temsirolimus, sorafenib, or pazopanib. These are all routine drugs for RCC treatment and will be given at their approved doses and dosing schedules.~Upon disease progression, subject's tumor(s) will be biopsied again to create another tumor profile. The second-line agents are everolimus or axitinib. Both of these are routine drugs for RCC treatment and will be given at their approved doses and dosing schedules.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: lack of efficacy