Please assess the completion status of the following clinical trial:

Trial Title: Effects of Intranasal Administration of a Single Dose of Oxytocin Using a Novel Device in Healthy Adults

Study Design Characteristics:
- Allocation: RANDOMIZED
- Intervention Model: CROSSOVER
- Observational Model: None
- Primary Purpose: BASIC_SCIENCE
- Time Perspective: None
- Masking: TRIPLE
- Phase: PHASE1
- Number of Arms: 4.0

Eligibility Criteria:
Inclusion Criteria:~* Healthy, male subjects aged 18 to 35 years inclusive.~* Subjects must be in good general health, as determined by the investigator.~* Subject's pre-study physical examination, vital signs and electrocardiogram (ECG) are normal or do not show any clinically significant abnormalities as determined by the investigator. Vital signs must not have any clinically significant deviations outside of the following ranges when measured sitting after 5 minutes rest:~  1. Heart rate: 40 to 90 beats per minute~ 2. Systolic blood pressure (BP): 90 to 140 mmHg~ 3. Diastolic BP: 50 to 90 mmHg~ 4. Oral temperature: 36.0 to 37.5°C~ 5. Respiratory rate: 12 - 18 breaths per minute~* Body Mass Index (BMI) of 18.5 - 29.9 kg/m2 (both inclusive)~* Subjects must be able to communicate well with the Investigator, to understand and comply with the requirements of the study, and understand and sign the written informed consent~* Provision of written informed consent.~Exclusion Criteria:~An ear, nose and throat (ENT) specialist will inspect the noses of all individuals who enter the study.~In order to participate in the study subjects must not meet any of the following exclusion criteria;~* Individuals showing major septal deviation or a significantly altered nasal epithelium.~* Participants with evidence of previous nasal disease, surgery, and dependence on inhaled drugs.~* Individuals with current significant nasal congestion due to common colds.~* Subjects with a clinically relevant history of significant hepatic, renal, endocrine, cardiac, nervous, psychiatric, gastrointestinal, pulmonary, haematological or metabolic disorder.~* Subjects with current or history of, any clinically significant disease or condition known to interfere with the absorption, distribution, metabolism or excretion of drugs.~* Subject is taking any regular prescribed or over-the-counter (OTC) medications including vitamin supplements and herbal remedies. There must be at least 14 days between stopping these products and the first dose of study medication).~* Systemic illness requiring treatment within 2 weeks prior to Study Day 1.~* History of significant drug or alcohol abuse (as per a self-report measure / instrument; World Health Organisation criteria/Alcohol use disorders identification test/Drug use disorders identification test). Subjects with a positive screen for alcohol or drugs of abuse at screening/admission will be excluded from participation in the study.~* Self-reported significant psychiatric conditions.~* Any abnormal laboratory values outside normal range, and which is clinically significant as deemed by investigator.~* Full scale intelligence quotient (IQ) \< 75 (due to the prerequisite ability to complete self report measures).~* Known allergic reactions or hypersensitivity to any component of the study medication in the nasal spray, such as E216, E218 and chlorobutanol hemihydrate.~* Participation in any (other) clinical trial with an investigational medicinal product or medical device within 3 months prior to randomisation.~* Current evidence of any mental or physical disorder or collaboration attitude which, in the judgment of the investigator makes the subject unsuitable for enrolment, and/or may interfere with the study evaluations or affect subject's safety.~* Subjects with any metal implants.~* Subjects with claustrophobia.~* Other unspecified reasons that, in the opinion of the Investigator or the sponsor make the subject unsuitable for enrolment.~* Subjects with female partners of child-bearing potential must use an adequate form of contraception prior to entry into the study until three months following the post-study medical visit. Subjects must not have a partner who is either pregnant or breastfeeding for the duration of the study. Adequate contraception is defined as the usage by the female partner of any form of hormonal contraception or intra-uterine device (which should be established prior to the start of the study) plus usage by one of the partners of an additional spermicide- containing barrier method of contraception.

- Gender: MALE
- Minimum Age: 18 Years
- Maximum Age: 35 Years
- Healthy Volunteers: t

Study Arms:
- 1 international unit (IU) intravenous oxytocin (Type: ACTIVE_COMPARATOR): Using a double-dummy design participants will be administered 1 IU oxytocin (mixed in 200 ml 0.9% sodium chloride) slow infusion with varying infusion rate over 20 minutes and placebo delivered with the OptiNose Breath Powered Bi-Directional liquid device. Subject to pilot data this may be increased to 2 IU oxytocin (mixed in 200 ml 0.9% sodium chloride) and the infusion time/rate may change to best match the pharmacokinetic profile of intranasally administered oxytocin.
- Placebo (Type: PLACEBO_COMPARATOR): Using a double-dummy design participants will be administered Placebo delivered with the OptiNose Breath Powered Bi-Directional liquid device and placebo delivered intravenously (0.9% sodium chloride 200 ml slow infusion for 20 minutes)
- 8IU intranasal oxytocin (Type: EXPERIMENTAL): Using a double-dummy design participants will be administered 8IU oxytocin liquid delivered with the OptiNose Breath Powered Bi directional liquid device and IV placebo (0.9% sodium chloride, 200 ml slow infusion for 20 minutes)
- 24IU intranasal oxytocin (Type: EXPERIMENTAL): Using a double-dummy design participants will be administered 24IU oxytocin liquid delivered with the OptiNose Breath Powered Bi directional liquid device and IV placebo (0.9% sodium chloride, 200 ml slow infusion for 20 minutes)

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: complete