Please assess the completion status of the following clinical trial:

Trial Title: ESK981 and Nivolumab for the Treatment of Metastatic Castration Resistant Prostate Cancer

Study Design Characteristics:
- Allocation: None
- Intervention Model: SINGLE_GROUP
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE2
- Number of Arms: 1.0

Eligibility Criteria:
Inclusion Criteria:~* Eastern Cooperative Group (ECOG) performance status =\< 1~* Recovery to baseline or =\< grade 1 Common Terminology Criteria for Adverse Events (CTCAE) version (v.)5 from toxicities related to any prior treatments, unless adverse event (AE)(s) are clinically non-significant and/or stable on supportive therapy~* Absolute neutrophil count (ANC) \>= 1.5 K/mm\^3~* Hemoglobin (Hgb) \>= 9 g/dL~* Platelets (Plt) \>= 100,000/mm\^3~* Serum creatinine =\< 1.5 times the upper limit of normal OR creatinine clearance \> 30 mL/min by Cockcroft-Gault formula~* Total bilirubin =\< 1.5 x upper limit of normal (ULN)~* Aspartate aminotransferase (AST) =\< 2.5 x ULN (=\< 5 x ULN with known hepatic metastases)~* Alanine aminotransferase (ALT) =\< 2.5 x ULN (=\< 5 x ULN with known hepatic metastases)~* Prothrombin time (PT) and activated partial thromboplastin time (aPTT) levels =\< 1.5 x ULN (If patient is receiving anticoagulation that is expected to alter these levels, should be in targeted therapeutic range for that agent)~* Patient must have progressive disease while receiving androgen deprivation therapy (ADT) defined by any one of the following as per the PCWG3 criteria for PSA, measurable or non-measurable (bone) disease and must have a castrate serum testosterone level (i.e. =\< 50 ng/dL) at screening:~  * PSA: At least two consecutive rises in serum PSA, obtained at a minimum of 1-week intervals, with the final value \>= 2.0 ng/mL~ * Measurable disease (by Response Evaluation Criteria in Solid Tumors \[RECIST\] 1.1): \>= 20% increase (with an absolute increase of at least 5 mm) in the sum of diameters of all measurable lesions or the development of one or more new lesions. The short axis of a target lymph node must be more than 15 mm to be assessed for change in size~ * Non-measurable (bone) disease: The appearance of two or more new areas of uptake on bone scan consistent with metastatic disease compared to previous imaging during castration therapy. The increased uptake of pre-existing lesions on bone scan will not be taken to constitute progression, and ambiguous results must be confirmed by other imaging modalities (e.g. X-ray, computed tomography \[CT\] or magnetic resonance imaging \[MRI\])~* Metastatic prostate cancer (M1) as documented by appropriate medical imaging (i.e. CT-Scan, positron emission tomography \[PET\] scan or bone scan)~* Progression on a hormonal agent (abiraterone/enzalutamide) and on a chemotherapy agent (docetaxel and/or cabazitaxel) in the metastatic castration resistant setting as per PCWG3 criteria~* Progression on chemotherapy (e.g. docetaxel, cabazitaxel) in the metastatic castration resistant setting. Progression of disease within 6 months of completing docetaxel in the metastatic castrate-sensitive setting is acceptable~* Have signed an informed consent document indicating that the subject understands the purpose of and procedures required for the study and are willing to participate in the study~* Be willing and able to adhere to the prohibitions and restrictions specified in this protocol~* Willingness to use contraception by a method that is deemed effective by the investigator throughout the treatment period and for at least 30 days following the last dose of therapy~* Willingness and ability to comply with study procedures and follow-up examination~* Able to swallow and retain oral medication~* Willingness and ability to undergo mandatory tumor biopsy at baseline and at the cycle 3 visit~* Willingness and ability to undergo mandatory whole blood sample collections at baseline, weeks 2-4 in the first cycle, and then monthly~Exclusion Criteria:~* Systemic therapy (other than a gonadotrophin releasing hormone \[GnRH\] agonist/antagonist) for CRPC within the past two weeks from cycle 1/day 1 including:~  * CYP-17 inhibitors (e.g. ketoconazole, abiraterone)~ * Antiandrogens (e.g. bicalutamide, nilutamide)~ * Second generation antiandrogens (e.g. enzalutamide, ARN-509, galeterone)~ * Immunotherapy (e.g. sipuleucel-T, ipilimumab)~ * Chemotherapy (e.g. docetaxel, cabazitaxel)~* Prior radiopharmaceutical therapy (e.g. radium-223, strontium-89, samarium-153, etc.) within the past year~* Have any condition that, in the opinion of the investigator, would compromise the well-being of the subject or the study or prevent the subject from meeting or performing study requirements~* The patient is currently on warfarin or heparin therapy~* The patient has any pre-existing coagulopathy, recent hemoptysis, gross hematuria or gastrointestinal bleeding~* The patient has a history of a clinically significant cardiovascular or cerebrovascular event within 3 months prior to study entry~* The patient has uncontrolled hypertension defined as a blood pressure measurement greater than 150 mm Hg systolic or 90 mm Hg diastolic with medication~* The patient has previously been enrolled in the study or received ESK981~* The patient has known hypersensitivity to gelatin or lactose monohydrate~* The patient has taken a medication known to be a potent inducer of CYP1A2, CYP2C8, or CYP3A4 within 4 weeks prior to the first dose of study drug~* Prior treatment with anti-PD/PD-L1/CTLA4/IDO antibody~* Untreated brain metastases or spinal cord compression~* Major surgical procedure or significant traumatic injury within 6 weeks prior to study registration. (\> 6 weeks prior to registration is permitted as long as they have fully recovered from any such procedure)~* History of another primary malignancy except for: malignancy treated with curative intent and no known active disease for \>= 5 years, adequately treated non-melanoma skin cancer without evidence of disease, adequately treated carcinoma in situ without evidence of disease~* Angina, myocardial infarction symptomatic congestive heart failure, cerebrovascular accident, transient ischemic attack, arterial embolism, pulmonary embolism, percutaneous angioplasty or Coronary arterial bypass surgery within the past 3 months~* The patient has received any investigational drug within 28 days prior to registration or 5 half-lives of the investigational drug, whichever is sooner

- Gender: MALE
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Treatment (ESK981, nivolumab) (Type: EXPERIMENTAL): Patients receive ESK981 PO QD for 5 consecutive days per week, followed by a 2-day break. Patients also receive nivolumab IV on day 1 of each cycle. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: enrollment issues