Please assess the completion status of the following clinical trial:

Trial Title: Study of Nintedanib Plus Bevacizumab in Advanced Solid Tumors

Study Design Characteristics:
- Allocation: NON_RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE1
- Number of Arms: 2.0

Eligibility Criteria:
Inclusion Criteria:~1. Age \>18~2. Histologically proven advanced or metastatic solid cancer for which Bevacizumab has an indication: renal cell carcinoma, colorectal adenocarcinoma, non-squamous non-small cell lung cancer, platinum- refractory ovarian carcinoma, cervical carcinoma.~3. Life expectancy at least 3 months~4. ECOG performance status score 0-1~5. Progression after at least first-line systemic therapy for metastatic disease~6. At least one measurable lesion according to RECIST criteria or any other baseline prerequisite for the assessment of the principal judgement criteria.~7. Signed and dated written informed consent prior to admission to the study~8. Resolution of all acute adverse events resulting from prior cancer therapies to NCI CTCAE grade less than/equal to 1 or baseline (except alopecia)~9. Adequate organ function as defined by the following criteria~   * AST/ALT ≤ 2.5x upper limit of normal (ULN) in the case of liver metastases or AST/ALT ≤ 1.5 x ULN in patients without liver metastases~  * total serum bilirubin within normal limits regardless of liver metastases~  * absolute neutrophil count (ANC) \> 1500~  * Platelets \> 100k without transfusion support in the past 28 days~  * Hemoglobin \> 9.0 without transfusion support in the past 28 days~  * Serum creatinine \< 1.5x ULN~  * Prothrombin time/INR and partial thromboplastin time within normal limits~  * Urinalysis ≤ 1+ protein~10. Willingness and ability to comply with scheduled visits, treatment plan, laboratory tests, and other study procedures~Exclusion Criteria:~1. Previous therapy with Bevacizumab is allowed, but patient who experienced serious dose-limiting toxicities while on prior Bevacizumab therapy are excluded~2. Prior treatment with Nintedanib (BIBF1120). Known hypersensitivity to Nintedanib, peanut or soya or any other trial drug, their excipients or to contrast media~3. Chemo-, hormone-, radio-(except for brain and extremities) or immunotherapy or therapy with monoclonal antibodies or small tyrosine kinase inhibitors within the past 4 weeks prior to treatment with the trial drug.~4. Radiotherapy to the target lesion within the past 3 months prior to baseline imaging~5. Persistence of clinically relevant therapy related toxicity from previous chemo and/or radiotherapy~6. History of brain involvement with cancer, spinal cord compression, carcinomatous meningitis, or new evidence of brain or leptomeningeal disease. Patients with irradiated or resected brain lesions are permitted provided the lesions are fully treated and inactive, patients are asymptomatic, and no steroids have been used for at least 28 days.~7. Leptomeningeal disease~8. Centrally located tumours with radiographic evidence of local invasion of major blood vessels~9. Treatment with other investigational drugs or treatment in another clinical trial within the past 4 weeks before start of therapy or concomitantly with the trial~10. Therapeutic anticoagulation (except low-dose heparin and/or heparin flush as needed for maintenance of an in-dwelling intravenous devise) or anti-platelet therapy (except for low-dose therapy with acetylsalicylic acid \<325mg per day.~11. Major injuries and/or surgery within the past 4 weeks prior to start of study treatment with incomplete wound healing and/or planned surgery during the on-treatment study period.~12. History of clinically significant hemorrhagic or thromboembolic event in the past 6 months.~13. Known inherited predisposition to bleeding or thrombosis~14. Significant cardiovascular diseases (i.e. uncontrolled hypertension, unstable angina, history of infarction within the past 6 months prior to start of study treatment, congestive heart failure \>New York Heart Association II, serious cardiac arrhythmia, pericardial effusion)~15. Proteinuria CTCAE grade 2 or greater~16. Creatinine \>1.5 ULN or GFR \<45 ml/min~17. Hepatic function: total bilirubin outside of normal limits; ALT or AST \>2.5 ULN in pts without liver metastasis. For patients with liver metastasis: total bilirubin outside of normal limits, ALT or AST \>5 x ULN~18. Coagulation parameters: International normalized ratio (INR) \>2, prothrombin time (PT) and partial thromboplastin time (PTT) \>50% of deviation of institutional ULN~19. Absolute neutrophil count (ANC) \<1500/ml, platelets \<100,000/ml, Hemoglobin \<9.0 g/dl~20. Other malignancies within the past 5 years other than basal cell skin cancer or carcinoma in situ of the cervix~21. Active serious infections in particular if requiring systemic antibiotic or antimicrobial therapy~22. Active or chronic hepatitis C and/or B infection~23. Gastrointestinal disorders or abnormalities that would interfere with absorption of the study drug~24. Serious illness or concomitant non-oncological disease such as neurologic, psychiatric, infectious disease or active ulcers (gastro-intestinal tract, skin) or laboratory abnormality that may increase the risk associated with study participation or study drug administration and in the judgment of the investigator would make the patient inappropriate for entry into the study.~25. Patients who are sexually active and unwilling to use a medically acceptable method of contraception (e.g. such as implants, injectables, combined oral contraceptives, some intrauterine devices or vasectomized partner for participating females, condoms for participating males) during the trial and for at least three months after end of active therapy.~26. Pregnancy or breast feeding. Female patients must have a negative pregnancy test (β-HCG test in urine or serum) prior to commencing study treatment and must agree with the use of effective contraception during the study and for three months following last dose of Nintedanib.~27. Psychological, familial, sociological or geographical factors potentially hampering compliance with the study protocol and follow-up schedule~28. Active alcohol or drug abuse~29. Minor surgical procedures such as Mediport placement or core biopsies within 7 days of study treatment~30. Stroke, transient ischemic attack, arterial embolism, percutaneous transluminal coronary angioplasty (PTCA), or coronary artery bypass grafting (CABG) within the past 6 months~31. History of pulmonary hemorrhage or hemoptysis within 6 months of starting study treatment~32. Open wounds or unhealed fractures within 28 days of starting study treatment~33. Known HIV or AIDS related illness

- Gender: ALL
- Minimum Age: 19 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Nintedanib 150 mg + Bevacizumab 15 mg/kg (Type: EXPERIMENTAL): The first three patients on study will be treated with 150 mg orally of Nintedanib two times daily plus 15 mg/kg of Bevacizumab administered intravenously on day one of each three week cycle.~If one dose limiting toxicity occurs in the first cohort, then three more patients will be treated at that same starting dose and assessed for toxicity after cycle two. If two or more patients have dose limiting toxicity, then dose escalation will end and the maximum tolerated dose will be reached.
- Nintedanib 200 mg + Bevacizumab 15 mg/kg (Type: EXPERIMENTAL): If no patients experience dose limiting toxicity, then three additional patients will be treated with 200 mg orally of Nintedanib two times daily plus 15 mg/kg of Bevacizumab administered intravenously on day one of each three week cycle.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: complete