Please assess the completion status of the following clinical trial:

Trial Title: Efficacy and Safety Study of Mepolizumab in Subjects With Moderate to Severe Atopic Dermatitis

Study Design Characteristics:
- Allocation: RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: DOUBLE
- Phase: PHASE2
- Number of Arms: 2.0

Eligibility Criteria:
Inclusion Criteria~* Age between 18 and 70 years of age inclusive, at the time of signing the informed consent.~* AD diagnosed by the Eichenfield revised criteria of Hanifin and Rajka.~* Diagnosis of AD \>=2 years prior to the Screening visit.~* An IGA score \>=3 at the Screening and Baseline visits.~* AD involvement of \>=10% body surface area at the Screening and Baseline visits.~* EASI score \>=16 at the Screening and Baseline visits.~* Absolute blood eosinophil count \>=350 cells/microliter at the Screening visit.~* Applied the same non-prescription, non-medicated (without an active ingredient) emollient twice daily for at least 7 days immediately before the Baseline visit.~* Recent history (\<=6 months prior to the Screening visit) of inadequate response to a stable regimen of prescription topical medication or for whom prescription topical medications are not tolerated or where there is a concern for potential side effects, such as skin thinning or increased risk of hypothalamic-pituitary-adrenal \[HPA\] suppression; as well as, inadequate response to optimization of non-pharmacological measures such as moisturizers. Inadequate response to a stable regimen of prescription topical medication (such as medium to high potency topical corticosteroids or topical calcineurin inhibitors) is defined as failure to achieve and maintain remission or low disease activity state (equivalent to an IGA score =0 \[clear\] to 2 \[mild\]) despite treatment for the recommended duration as per label or for the maximum duration recommended for the subject treatment, whichever is shorter.~* Male or female: A female subject is eligible to participate if she is not pregnant (as confirmed by a negative urine human chorionic gonadotrophin (hCG) test), not lactating, and at least one of the following conditions: Non-reproductive potential- Pre-menopausal females with documented tubal ligation, documented hysteroscopic tubal occlusion procedure with follow-up confirmation of bilateral tubal occlusion, hysterectomy, documented bilateral oophorectomy; and postmenopausal defined as 12 months of spontaneous amenorrhea (in questionable cases a blood sample with simultaneous follicle stimulating hormone \[FSH\] and estradiol levels consistent with menopause). Females on hormone replacement therapy (HRT) and whose menopausal status is in doubt will be required to use one of the highly effective contraception methods if they wish to continue their HRT during the study. Otherwise, they must discontinue HRT to allow confirmation of post-menopausal status prior to study enrolment. Reproductive potential and agrees to follow one of the options listed in the Modified List of Highly Effective Methods for Avoiding Pregnancy in Females of Reproductive Potential (FRP) from 30 days prior to the first dose of study medication and until 16 weeks after the last dose of study medication.~* The investigator is responsible for ensuring that subjects understand how to properly use these methods of contraception.~* Subject is able to give signed informed consent that includes compliance with the requirements and restrictions listed in the consent form and in this protocol.~Exclusion Criteria~* Other types of eczema.~* Any other concomitant skin disorder (e.g., generalized erythroderma such as Netherton's Syndrome, or psoriasis), pigmentation, or extensive scarring that in the opinion of the investigator may interfere with the evaluation of AD lesions or compromise subject safety.~* Immunocompromised (e.g., lymphoma, acquired immunodeficiency syndrome, Wiskott-Aldrich Syndrome) or has a history of malignant disease within 5 years before the Baseline visit. Note: Subjects with successfully treated basal cell carcinoma (no more than 3 lesions), squamous cell carcinoma of the skin, or cervical carcinoma in situ, with no evidence of recurrence within the 3 years prior to the Baseline visit may participate in the study.~* A positive history for human immunodeficiency virus (HIV) antibody.~* Chronic or acute infection requiring treatment with oral or intravenous (IV) antibiotics, antivirals, anti-protozoals, or antifungals within 4 weeks before the Screening visit or anytime between the Screening and Baseline visits.~* Superficial skin infections within 1 week before the Screening visit.~* Known, pre-existing or suspected parasitic infection within 6 months before the Screening visit.~* Other known or suspected conditions that could lead to elevated eosinophils, for example, hypereosinophilic syndromes including eosinophilic granulomatosis with polyangiitis (EGPA, also known as Churg-Strauss Syndrome), eosinophilic esophagitis, or severe asthma.~* A history or ongoing serious illness or medical, physical, or psychiatric condition(s) that, in the investigator's opinion, may interfere with the subject's completion of the study.~* ALT \>2x upper limit of normal (ULN)~* Bilirubin \>1.5x ULN (isolated bilirubin \>1.5xULN is acceptable if bilirubin is fractionated and direct bilirubin \<35%).~* Current or chronic history of liver disease, or known hepatic or biliary abnormalities (with the exception of Gilbert's syndrome or asymptomatic gallstones).~* QT Interval Corrected by Fridericia Correction Formula (QTcF) \>450 milliseconds (msec) or QTcF \>480 msec in subjects with Bundle Branch Block.~* Clinically significant abnormality in the hematological or biochemical screen, as judged by the investigator.~* Previously treated with mepolizumab or participated in a previous mepolizumab clinical study.~* Prior treatment with any of the medications or treatments listed in Table 1 within the indicated periods before the Screening visit.~* Prolonged exposure to natural (e.g, sunlight) ultraviolet (UV) radiation within 4 weeks prior to the Baseline visit and/or intention to have such exposure during the study, which is thought by the investigator to potentially impact the subject's AD.~* More than 2 visits per week to a tanning booth or parlor in the 4 weeks prior to the Baseline visit.~* Onset of a new exercise routine or major change to a previous exercise routine within 2 weeks before randomization, or unwilling to maintain current level of physical activity throughout the length of participation in this study.~* History of alcohol or other substance abuse within the last 2 years.~* Hypersensitivity to mepolizumab or any of its excipients.~* Presence of hepatitis B surface antigen (HBsAg), positive hepatitis C antibody test result at screening or within 3 months prior to first dose of study treatment.~* Exposure to more than 4 investigational medicinal products within 12 months prior to the Baseline visit.~* Subject is a member of the investigational team or his/her immediate family.

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: 70 Years
- Healthy Volunteers: f

Study Arms:
- Mepolizumab (Type: EXPERIMENTAL): Eligible subjects will receive mepolizumab 100 mg subcutaneously every 4 weeks on Day 1, Week 4, Week 8, and Week 12
- Placebo (Type: PLACEBO_COMPARATOR): Eligible subjects will receive matching placebo subcutaneously every 4 weeks on Day 1, Week 4, Week 8, and Week 12

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: lack of efficacy