Please assess the completion status of the following clinical trial:

Trial Title: Efficacy and Safety of Ambrisentan in Children 8-18yrs

Study Design Characteristics:
- Allocation: RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: SINGLE
- Phase: PHASE2
- Number of Arms: 2.0

Eligibility Criteria:
Inclusion Criteria:~* Current diagnosis of PAH (WHO Group 1) with WHO class II or III symptoms in one of the following categories: Idiopathic, Heritable \[familial\], Secondary to connective tissue disease (e.g., limited scleroderma, diffuse scleroderma, mixed connective tissue disease (CTD), systemic lupus erythematosus, or overlap syndrome), or Persistent PAH despite surgical repair (at least 6 months prior to the screening visit) of atrial septal defects, ventricular septal defects, atrio-ventricular septal defects, and persistent patent ductus.~* Have met the following hemodynamic criteria for subjects with right heart catheterization (RHC) when performed as part of the diagnosis or routine care: mean pulmonary arterial pressure (mPAP) of \>/=25 mmHg, pulmonary vascular resistance (PVR) of \>/=240 dyne sec/cm5, left ventricular end diastolic pressure (LEVDP) or pulmonary capillary wedge pressure (PCWP) of ≤15 mmHg.~* be treatment naïve, have discontinued treatment with another ERA (e.g., bosentan) at least 1 month previously because of elevated liver function tests (LFTs), or have been on a stable dose of drug therapy for PAH (e.g., sildenafil or prostacyclin) for at least one month prior to the Screening Visit.~* Subjects who discontinued ERA treatment due to elevated LFTs, must have LFTs of \<3 x Upper Limit of Normal (ULN).~* A female is eligible to participate in this study, as assessed by the investigator, if she is of: a. non-childbearing potential (i.e., physiologically incapable of becoming pregnant); or, b. Child-bearing potential - has a negative pregnancy test and is not lactating at the Screening and Baseline/Randomisation Visits and, if sexually active, agrees to use 2 reliable methods of contraception from the Screening Visit until study completion and for at least 30 days following the last dose of study drug.~* Subject or subject's legal guardian is able and willing to give written informed consent. As part of the consent, female subjects of childbearing potential will be informed of the risk of teratogenicity and will need to be counselled in a developmentally appropriate manner on the importance of pregnancy prevention; and male subjects will need to be informed of potential risk of testicular tubular atrophy and aspermia.~Exclusion Criteria:~* currently taking an ERA.~* currently taking cyclosporine A.~* body weight is less than 20 Kg.~* have not tolerated PAH therapy due to adverse effects which may be related to their mechanism of action (e.g., prostanoids, ERA, PDE-5 inhibitors) with the exception of liver abnormalities for those subjects who were receiving another ERA.~* pregnant or breastfeeding.~* diagnosis of active hepatitis (hepatitis B surface antigen and hepatitis C antibody), or clinically significant hepatic enzyme elevation (i.e., ALT, AST or AP \>3xULN) at Screening.~* severe renal impairment (creatinine clearance \<30 mL/min) at Screening.~* clinically significant fluid retention in the opinion of the investigator.~* clinically significant anaemia in the opinion of the investigator.~* a known hypersensitivity to the study drug, the metabolites, or formulation excipients.~* have participated in another trial or have taken another investigational product during the previous 30 days.~* alcohol abuse, illicit drug use within 1 year.~* any concurrent condition or concurrent use of medication that would affect subject safety in the opinion of the investigator.

- Gender: ALL
- Minimum Age: 8 Years
- Maximum Age: 18 Years
- Healthy Volunteers: f

Study Arms:
- Low Dose Ambrisentan (Type: EXPERIMENTAL): body weight 20 to 35 kg - 2.5 mg; body weight 35 kg and over - 5.0 mg
- High Dose Ambrisentan (Type: EXPERIMENTAL): body weight 20 to 35 kg - 5.0 mg; body weight 35 to 50 kg - 7.5 mg; body weight 50 kg and over - 10.0 mg

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: safety issues