Please assess the completion status of the following clinical trial:

Trial Title: Vemurafenib Plus Cobimetinib in Advanced or Metastatic Melanoma Patients

Study Design Characteristics:
- Allocation: None
- Intervention Model: SINGLE_GROUP
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE2
- Number of Arms: 1.0

Eligibility Criteria:
Inclusion Criteria:~1. Patients must have histologically confirmed, unresectable stage IIIc or stage IV metastatic melanoma, as defined by the American Joint Committee on Cancer 7th edition. Unresectability of stage IIIc disease must have confirmation from a surgical oncologist;~2. Patients with advanced melanoma who have received one prior immunotherapy systemic regimen for advanced disease, for whom vemurafenib/cobimetinib treatment has been scheduled by the treating physician.~3. Adjuvant treatment is allowed, except for anti-PD-1, anti-PD-L1, anti-PD-L2, anti-CD137, or anti-CTLA-4 agents;~4. Patients must be naïve to treatment for locally advanced unresectable or metastatic with BRAF/MEK inhibitors;~5. Documentation of BRAFV600 mutation-positive status in melanoma tumor tissue BRAF V600 mutation test;~6. At least one measurable lesion according to disease per RECIST v1.1 criteria;~7. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0- 2;~8. Male or female patient aged ≥ 18 years;~9. Able to participate and willing to give written informed consent prior to performance of any study-related procedures and to comply with the study protocol;~10. Life expectancy ≥ 12 weeks.~Exclusion Criteria:~1. History of any prior systemic treatment for unresectable stage IIIc or stage IV melanoma (prior anti RAF or MEK agents) other than one prior first-line immunotherapy;~2. Palliative radiotherapy within 14 days prior to the first dose of study treatment;~3. Major surgery or traumatic injury within 14 days prior to first dose of study treatment;~4. Patients with active malignancy (other than BRAF- mutated melanoma) or a previous malignancy within the past 3 years are excluded; except for patients with resected melanoma, resected BCC,resected cutaneous SCC, resected melanoma in-situ, resected carcinoma in-situ of the cervix, and resected carcinoma in-situ of the breast; Exclusion Criteria Based on Organ Function.~   Ocular:~5. History of, or evidence of retinal pathology on ophthalmologic examination that is considered a risk factor for neurosensory retinal detachment/central serouschorioretinopathy (CSCR), retinal vein occlusion (RVO) or neovascularmacular degeneration;~6. The risk factors for RVO are listed below. Patients will be excluded if they currently have the following conditions:~   1. Uncontrolled glaucoma with intra-ocular pressures ≥21 mmHg;~  2. Serum cholesterol ≥Grade 2;~  3. Hypertriglyceridemia ≥ Grade 2;~  4. Hyperglycemia (fasting) ≥Grade 2;~   Cardiac:~7. History of clinically significant cardiac dysfunction, including the following:~   1. Current unstable angina;~  2. Symptomatic congestive heart failure of New York Heart Association class 2 or higher;~  3. History of congenital long QT syndrome or mean (average of triplicate measurements) QTcF ≥ 450 msec at baseline or uncorrectable abnormalities inserum electrolytes (sodium, potassium, calcium, magnesium, phosphorus);~  4. Uncontrolled hypertension≥ Grade 2 (patients with a history hypertension controlled with anti-hypertensives to ≤ Grade 1 are eligible);~  5. Left ventricular ejection fraction (LVEF) below institutional lower limit of normal (LLN) or below 50%, whichever is lower.~   Central Nervous System:~8. Patients with active/symptomatic CNS lesions are excluded.

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Single arm (Type: EXPERIMENTAL): Vemurafenib will be orally adminitered at 960 mg b.i.d. on Days 1-28. Cobimetinib will be given orally at 60 mg qd on Days 1-21 of each 28-day treatment cycle until disease progression.~Treatments will be continued until the development of progressive disease (as per Investigator assessment), unacceptable toxicity, consent withdrawal, death, reasons deemed by the treating physician or study termination by the Sponsor.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: terminate
termination_type: enrollment issues