Please assess the completion status of the following clinical trial:

Trial Title: Assessment of Safety, Tolerability, Immunogenicity, and Pharmacokinetics of AZD3427

Study Design Characteristics:
- Allocation: RANDOMIZED
- Intervention Model: PARALLEL
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: DOUBLE
- Phase: PHASE1
- Number of Arms: 15.0

Eligibility Criteria:
Inclusion Criteria:~* Part A will include healthy men and non-pregnant, non-lactating females of non-childbearing potential with a body mass index (BMI) of 18-30 kg/m\^2 and a weight of 55-100 kg. One cohort will require participants be of Japanese descent~* Part B will include men and non-pregnant, non-lactating females of non-childbearing potential~* Participants have a BMI of 18-40 kg/m\^2 and a weight of 55-136 kg~* Participants with a diagnosis of stage C HF New York Heart Association (NYHA) Class I-III on stable medical therapy for at least 12 weeks~* Participants with diagnosis of HFrEF will be defined as those with EF ≤ 40% and HF with EF ≥ 41%~* Participants either with N-terminal prohormone of brain natriuretic peptide (NT-proBNP) \> 125 pg/mL or BNP \> 35 pg/mL (46)~Exclusion Criteria:~Both Part A and Part B will exclude participants with any of the following:~* Any clinically important illness, medical/surgical procedure or trauma within 4 weeks of the first administration of study drug or planned surgical procedure before study completion~* History of vascular and left ventricular aneurysms or prior dissections~* Any history of joint hypermobility, Marfan's syndrome, or any connective tissue disorder~* Clinical signs and symptoms consistent with Coronavirus disease-19 or confirmed infection within the last 4 weeks~* History of severe allergy/hypersensitivity or ongoing clinically important allergy/hypersensitivity, as judged by the Investigator, or history of hypersensitivity injection devices or to drugs with a similar chemical structure or class to AZD3427 or any component of AZD3427~In addition, Part A will exclude participants with any of the following:~* Alanine Aminotransferase (ALT) \> Upper limit of normal (ULN)~* Aspartate Aminotransferase (AST) \> ULN~* Total bilirubin \> ULN (unless due to Gilbert's syndrome)~* Creatinine \> ULN~* White blood cell (WBC) count \< Lower limit of normal (LLN)~* Hemoglobin \< LLN~* Prolonged QTcF \> 450 m~* Shortened QTcF \< 340 ms~* Family history of long QT syndrome~* PR (PQ) interval shortening \< 120 ms (PR \> 110 ms but \< 120 ms is acceptable if there is no evidence of ventricular pre-excitation)~* PR (PQ) interval prolongation (\> 240 ms) intermittent second (Wenckebach block while asleep is not exclusive) or third-degree atrioventricular (AV) block, or AV dissociation~* Persistent or intermittent complete bundle branch block, incomplete bundle branch block, or intraventricular conduction delay with QRS \> 110 ms. Participants with QRS \> 110 ms but \< 115 ms are acceptable if there is no evidence of eg, ventricular hypertrophy or pre-excitation~In addition, Part B will exclude participants with any of the following:~* Atrial fibrillation or flutter occurring in the past year~* Clinically significant ventricular arrhythmias under treatment~* High-degree AV block II-III or sinus node dysfunction~* Implanted permanent pacemaker or implantable cardioverter defibrillator for which the participant is pacing-dependent~* Severe right-sided valvular heart disease; severe mitral regurgitation; moderate or severe mitral stenosis, severe aortic regurgitation and mild, moderate or severe aortic stenosis~* Other conditions where vasodilatory therapy may be contraindicated (hypertrophic obstructive cardiomyopathy, and restrictive cardiomyopathy)~* Congenital heart disease~* NYHA HF Class IV~* Occurrence in the last 6 months of acute coronary syndrome, percutaneous coronary intervention, cerebrovascular accident or transient ischemic attack, HF hospitalization; history or suspicion of cardiac amyloidosis~* ALT \> 1.5 × ULN~* AST \> 1.5 × ULN~* Total bilirubin \> ULN (unless due to Gilbert's syndrome)~* Impaired renal function, defined as eGFR \< 30 mL/min/1.73m\^2 assessed by the Chronic Kidney Disease Epidemiology Collaboration equation~* WBC \< LLN~* Hemoglobin \< 10g/L~* PR (PQ) interval prolongation (\> 220 ms)~* Participants with persistent BBB and QRS (ECG interval measured from the onset of the QRS complex to the J point) duration \> 130 ms. Participants with intraventricular conduction delay and QRS duration \< 130 ms

- Gender: ALL
- Minimum Age: 18 Years
- Maximum Age: 75 Years
- Healthy Volunteers: t

Study Arms:
- AZD3427: Cohort 1a (Type: EXPERIMENTAL): Participants will receive single SC dose A of AZD3427 on Day 1.
- AZD3427: Cohort 2a (Type: EXPERIMENTAL): Participants will receive single SC dose B of AZD3427 on Day 1.
- AZD3427: Cohort 3a (Type: EXPERIMENTAL): Participants will receive single SC dose C of AZD3427 on Day 1.
- AZD3427: Cohort 4a (Type: EXPERIMENTAL): Participants will receive single SC dose D of AZD3427 on Day 1.
- AZD3427: Cohort 5a (Type: EXPERIMENTAL): Participants will receive single IV dose E of AZD3427 on Day 1.
- AZD3427: Cohort 6a (Type: EXPERIMENTAL): Participants of Japanese descent will receive single SC dose anticipated equal to the highest dose of AZD3427 in the global cohorts on Day 1.
- AZD3427: Cohort 7a (Type: EXPERIMENTAL): Participants will receive single SC dose F of AZD3427 on Day 1
- Part A: Placebo (Type: PLACEBO_COMPARATOR): Participants will receive single SC or IV dose of placebo matched to AZD3427 on Day 1.
- AZD3427: Cohort 1b (Type: EXPERIMENTAL): Participants with HFrEF will receive SC dose A of AZD3427 on Days 1, 8, 15, 22, and 29.
- AZD3427: Cohort 2b (Type: EXPERIMENTAL): Participants with HF with EF ≥ 41% will receive SC dose A of AZD3427 on Days 1, 8, 15, 22, and 29.
- AZD3427: Cohort 3b (Type: EXPERIMENTAL): Participants with HFrEF will receive SC dose B of AZD3427 on Days 1, 8, 15, 22, and 29.
- AZD3427: Cohort 4b (Type: EXPERIMENTAL): Participants with HF with EF ≥ 41% will receive SC dose B of AZD3427 on Days 1, 8, 15, 22, and 29.
- AZD3427: Cohort 5b (Type: EXPERIMENTAL): Participants with HFrEF will receive SC dose C of AZD3427 on Days 1, 8, 15, 22, and 29.
- AZD3427: Cohort 6b (Type: EXPERIMENTAL): Participants with HF with EF ≥ 41% will receive SC dose C of AZD3427 on Days 1, 8, 15, 22, and 29.
- Part B: Placebo (Type: PLACEBO_COMPARATOR): Participants with HFrEF or HF with EF ≥ 41% will receive SC dose of placebo matched to AZD3427 on Days 1, 8, 15, 22, and 29.

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: complete