Please assess the completion status of the following clinical trial:

Trial Title: Clinical Protocol to Investigate the Efficacy of Recombinant Human Leptin (Metreleptin) in Nonalcoholic Steatohepatitis (NASH) or Nonalcoholic Fatty Liver Disease (NAFLD) Associated With Lipodystrophy

Study Design Characteristics:
- Allocation: None
- Intervention Model: SINGLE_GROUP
- Observational Model: None
- Primary Purpose: TREATMENT
- Time Perspective: None
- Masking: NONE
- Phase: PHASE2
- Number of Arms: 1.0

Eligibility Criteria:
Inclusion Criteria:~* Is male or female ≥ 5 years old at baseline.~* Is male, female not of childbearing potential, or meets all the following criteria if female of childbearing potential (including perimenopausal women who have had a menstrual period within one year):~  * Not breastfeeding~ * Negative pregnancy test result (human chorionic gonadotropin, beta subunit \[βhCG\]) at baseline (not applicable to hysterectomized females).~ * Must practice and be willing to continue to practice appropriate birth control (defined as a method which results in a low failure rate when use consistently and correctly, such as implants, injectables, oral contraceptives, some intrauterine contraceptive devices, sexual abstinence, tubal ligation, or a vasectomized partner) during the entire duration of metreleptin treatment.~* Has physician-confirmed lipodystrophy as defined by evidence of generalized (whole body) or partial (limbs) loss of body fat outside the range of normal variation.~* Alcohol consumption of less than 40 grams/week.~* A liver ultrasound confirming non-alcoholic fatty liver disease, or previous liver biopsy confirming NASH status.~* If ≥ 18 years of age, is able to read, understand and sign the U of M IRBMED approved informed consent form (ICF), communicate with study physician and study team, understand and comply with protocol requirements.~* If \< 18 and ≥ 7 years of age, is able to read, understand and sign the appropriate U of M IRBMED approved assent form and has a parent or legal guardian that is able to read, understand and sign the ICF.~* If \< 7 and ≥ 5 years of age or unable to read, the appropriate assent form must be explained to the child.~* If previously treated with thiazolidinediones or Vitamin E, stable dose of these medications for at least 3 months.~Exclusion Criteria:~* Presence of advanced liver disease (as evidenced by abnormal synthetic function, abnormal PT or albumin).~* Evidence of other etiologies of viral hepatitis.~* Presence of clinically significant hematologic abnormalities (such as neutropenia and/or lymphadenopathy).~* Presence of HIV infection.~* Very poorly controlled diabetes; HbA1c \>10%~* Inability to give informed consent.~* Presence of ESRD, any type of active cancer, or \>class 2 congestive heart failure ((New York Heart Association Functional Classification System), based on medical history and physical examination.~* Active infection (may be transient).~* Has known allergies to E. coli-derived proteins or hypersensitivity to any component of metreleptin treatment.~* Any other condition in the opinion of the investigators that may impede successful data collection.

- Gender: ALL
- Minimum Age: 5 Years
- Maximum Age: None
- Healthy Volunteers: f

Study Arms:
- Treatment (Type: EXPERIMENTAL): Metreleptin

Based on this trial design, predict the completion outcome and termination type (if applicable).

Answer: outcome: complete